title: A randomized, prospective, blinded, split-face, single-center study comparing polycaprolactone to hyaluronic acid for treatment of nasolabial folds.
abstract: BACKGROUND
  Dermal fillers have continuingly been under development to increase safety, efficacy, and longevity. Biostimulatory dermal fillers, such as calcium hydroxylapatite fillers, have already been shown to be superior in efficacy compared to nonanimal stabilized hyaluronic acid (NASHA)-based fillers.
  
  
  OBJECTIVE
  In this randomized split-face study, we compared a novel biostimulatory polycaprolactone (PCL)-based dermal filler with a NASHA-based dermal filler, for safety, efficacy, and duration of cosmetic correction for the treatment of nasolabial folds (NLFs).
  
  
  METHODS
  Forty subjects received a PCL-based dermal filler in one of their NLFs, and a NASHA-based dermal filler on the contralateral side. Efficacy was evaluated based on the Wrinkle Severity Rating Scale and Global Aesthetic Improvement Scale.
  
  
  RESULTS
  After 6, 9, and 12 months post-treatment, NLFs treated with the PCL-based dermal filler showed statistically significant improvements on the Wrinkle Severity Rating Scale and greater improvements on the GAIS compared to NLFs treated with the NASHA-based dermal filler. Both products were found to be equally safe and well tolerated.
  
  
  CONCLUSIONS
  Our results suggest that PCL-based dermal fillers offer longer-lasting performance over NASHA-based dermal fillers in NLFs treatment.
authors.affiliation: Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
authors.forename: Hassan
authors.initials: H
authors.lastname: Galadari
authors.forename: Daan
authors.initials: D
authors.lastname: van Abel
authors.forename: Khawla
authors.initials: K
authors.lastname: Al Nuami
authors.forename: Fatima
authors.initials: F
authors.lastname: Al Faresi
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Galadari
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000009:adverse effects; D003357:Cosmetic Techniques / Q000009:adverse effects; D004954:Esthetics; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold; D011091:Polyesters / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; C502935:Perlane; D011091:Polyesters; C016240:polycaprolactone; D006820:Hyaluronic Acid
keywords: facial filler; hyaluronic acid; nasolabial folds; polycaprolactone