title: To study prevalence of persistent pulmonary hypertension in newborn with meconium aspiration syndrome in western Rajasthan, India: a prospective observational study.
abstract: OBJECTIVE
  To study the prevalence of persistent pulmonary hypertension (PPHN) in newborn with meconium aspiration syndrome (MAS) in western Rajasthan, India.
  
  
  METHODS
  Hundred full-term newborns who had features of MAS at birth were included in this survey and were evaluated for PPHN using laboratory investigations, including pulse oximetry, ABG, chest X-ray, ECG and 2D color echocardiography.
  
  
  RESULTS
  Nineteen neonates showed PPHN, of them 16 had a shunt reversal at PFO level and the rest at PDA level. Most of these newborns were delivered by emergency cesarean section and were unplanned. A majority of neonates of PPHN (84.21%) were diagnosed within 48 h of life and 73.69% had Downey's score more than 6. Neonates of PPHN had mean PH 7.21 ± 0.07, mean PCO2 53.73 ± 6.8, mean PaO2 61.10 ± 10.61 and mean PaO2/FiO2 144.03 ± 46.31.
  
  
  CONCLUSIONS
  PPHN is a genuine problem in MAS-born neonates and is commonly seen in neonates born by unplanned and unmonitored delivery, and the prevalence of PPHN can be reduced by providing good antenatal care, regular follow up of high-risk pregnancy. 2D echocardiography is an important point of care in the diagnosis of PPHN in nursery and should be promoted in nurseries of developing countries as being engaged in developed countries for more reliable treatment.
authors.affiliation: a Department of Medical and Paediatric Oncology , GCRI , Ahmedabad , Gujarat , India .
authors.forename: Mukesh
authors.initials: M
authors.lastname: Choudhary
authors.affiliation: b Department of Pediatrics , Govt HBK District Hospital , Jaipur , Rajasthan , India .
authors.forename: Mahesh Kumar
authors.initials: MK
authors.lastname: Meena
authors.affiliation: c Department of Paediatrics , Umaid Hospital, S.N. Medical College , Jodhpur , Rajasthan , India .
authors.forename: Narendra
authors.initials: N
authors.lastname: Chhangani
authors.affiliation: d Department of Neonatology , Fernandez hospital , Hyderabad , Telangana , India .
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.affiliation: e Department of Pediatrics , Bhagvan Mahaveer Hospital , Pitampura , New Delhi , India , and.
authors.forename: Jagveer Singh
authors.initials: JS
authors.lastname: Choudhary
authors.affiliation: f Department of Pediatrics , Baba Sahib Amededkar Hospital , New Delhi , India.
authors.forename: Sushil Kumar
authors.initials: SK
authors.lastname: Choudhary
mesh_terms: D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000150:complications*; D010547:Persistent Fetal Circulation Syndrome / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies
keywords: Meconium aspiration syndrome; neonates; persistent pulmonary hypertension