title: Salpingectomy as a means to reduce ovarian cancer risk.
abstract: Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the molecular pathways of ovarian cancer point to the fallopian tube epithelium as the origin of most high-grade serous cancers (HGSC). This evolving appreciation of the role of the fallopian tube in HGSC has led to the consideration of salpingectomy alone as an option for risk management, especially in premenopausal women. In addition, it is postulated that bilateral salpingectomy with ovarian retention (BSOR), may have a public health benefit for women undergoing benign gynecologic surgery. In this review, we provide the rationale for salpingectomy as an ovarian cancer risk reduction strategy.
authors.affiliation: Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Mary.Daly@fccc.edu.
authors.forename: Mary B
authors.initials: MB
authors.lastname: Daly
authors.affiliation: Department of Translational Outcomes Research Group of the Translational Research Program of the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Dresher
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Melinda S
authors.initials: MS
authors.lastname: Yates
authors.affiliation: Department of Medicine, University of Arizona, Tucson, Arizona.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Jeter
authors.affiliation: Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
authors.forename: Beth Y
authors.initials: BY
authors.lastname: Karlan
authors.affiliation: University of Arizona Cancer Center, Tucson, Arizona.
authors.forename: David S
authors.initials: DS
authors.lastname: Alberts
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Karen H
authors.initials: KH
authors.lastname: Lu
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D017558:Elective Surgical Procedures / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D065286:Prophylactic Surgical Procedures / Q000706:statistics & numerical data; D012307:Risk Factors; D040242:Risk Reduction Behavior; D058994:Salpingectomy / Q000706:statistics & numerical data*