title: Is CD10 antibody useful in the diagnosis of angioimmunoblastic T-cell lymphoma?
abstract: Angioimmunoblastic T-cell lymphoma (AITL) is a rare lymphoma accounting for less than 1% of non Hodgkin lymphomas. The lack of specific clinical and histologic features in addition to the multiplicity of morphologic mimickers makes the diagnosis challenging. Some authors reported the utility of CD10 antibody as a diagnostic marker. Our aim is to explore the value of this marker through a presentation of a study about four cases diagnosed over a six-year-period and a mini-review of the literature. We present a study of 4 cases of AITL diagnosed in lymph node biopsies. Microscopic findings showed in all cases early AITL characterized by a pattern I. The diagnosis of AITL was made in all cases based on the morphologic and immunohistochemical features. The CD3 antibody was expressed in all cases but CD10 antibody was negative in all cases. All the patients died and the initiation of a conventional chemotherapy wasn't possible in all cases because of the rapid course of the disease. Because of the small number of our cases, we can't rule out a possible diagnostic value of CD10 but its negativity in all our cases makes us doubt its sensitivity.
authors.affiliation: a Department of Pathology , Abderrahman Mami Hospital , El Manar , Tunisia.
authors.forename: Mona
authors.initials: M
authors.lastname: Mlika
authors.forename: Imen
authors.initials: I
authors.lastname: Helal
authors.forename: Soumeya
authors.initials: S
authors.lastname: Laabidi
authors.forename: Emna
authors.initials: E
authors.lastname: Braham
authors.forename: Faouzi
authors.initials: F
authors.lastname: El Mezni
mesh_terms: D000328:Adult; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000276:immunology*
chemical_list: D000906:Antibodies; D015260:Neprilysin
keywords: CD10 antibody; angioimmunoblastic lymphoma; diagnosis; pathology