title: Cell Index Database (CELLX): a web tool for cancer precision medicine.
abstract: The Cell Index Database, (CELLX) (http://cellx.sourceforge.net) provides a computational framework for integrating expression, copy number variation, mutation, compound activity, and meta data from cancer cells. CELLX provides the computational biologist a quick way to perform routine analyses as well as the means to rapidly integrate data for offline analysis. Data is accessible through a web interface which utilizes R to generate plots and perform clustering, correlations, and statistical tests for associations within and between data types for ~20,000 samples from TCGA, CCLE, Sanger, GSK, GEO, GTEx, and other public sources. We show how CELLX supports precision oncology through indications discovery, biomarker evaluation, and cell line screening analysis.
authors.affiliation: Oncology Research Unit, Pfizer Global Research & Development, Pfizer Inc., 10777 Science Center Drive San Diego, CA 92121, USA. keith.ching@pfizer.com.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Ching
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Kan
authors.forename: Julio
authors.initials: J
authors.lastname: Fernandez
authors.forename: Wenyan
authors.initials: W
authors.lastname: Zhong
authors.forename: Jarek
authors.initials: J
authors.lastname: Kostrowicki
authors.forename: Tao
authors.initials: T
authors.lastname: Xie
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Martini
authors.forename: Maria
authors.initials: M
authors.lastname: Koehler
authors.forename: Kim
authors.initials: K
authors.lastname: Arndt
authors.forename: Paul
authors.initials: P
authors.lastname: Rejto
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D045744:Cell Line, Tumor; D019295:Computational Biology; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine; D012984:Software
chemical_list: D014408:Biomarkers, Tumor