title: Energy status and metabolism in intracranial space occupying lesions: a prospective 31p spectroscopic study.
abstract: OBJECTIVE
  Intracranial space occupying lesions can be infective or tumour. There are various advanced Magnetic resonance imaging techniques like perfusion, diffusion and proton spectroscopy which can differentiate between them. However, (31) Phosphorus spectroscopy studies the energy status and the metabolism pattern of various tissues and can be used potentially to differentiate between them depending on their Metabolism pattern. Thus, we aimed to study energy status of various intracranial lesions and try to differentiate between them including grades of gliomas.
  
  
  METHODS
  (31)PMRS was done in 1.5T MRI in 43 patients prior to surgery or through/via stereo-tactic biopsy, of which 25 were men and 18 women with mean age 41.34 y ranging from 7-71 y. Single voxel phosphorus spectroscopy was done from the solid portion of the lesions and data was analysed and post processed.
  
  
  RESULTS
  Study includes Lymphoma (n=6), Grade 1 and 2 glioma (n=5), grade 3 glioma (n=9), grade 4 glioma(n=6), metastases (n=5), tuberculoma (n=7) and pyogenic abscesses (n=5). The integral values of PME, Pi, PDE, γ-ATP, α-ATP, β-ATP with reference to the position of PCr were calculated along with various ratios. Integral values of Pi and PDE were significantly increased in metastases but decreased in gliomas grade 1-2 compared to other pathologic conditions. Mean integral values of LEP (low energy phosphates) and total phosphates were significantly decreased in gliomas grades 1 and 2 and increased in metastases when compared with other pathologic conditions. PCr /Pi was increased in glioma grades 1, 2 and 3 but decreased in metastases; the significance was observed only in gliomas grade 3 and metastases. Metabolic ratios of PDE/β ATP and Pi/βATP were decreased in glioma grades 1 and 2 and increased in metastases with statistical significance.
  
  
  CONCLUSIONS
  (31)PMRS may help in differentiating primary from secondary lesions and assess grades of gliomas.
authors.affiliation: Head of Department, Department of Radiology, Bangalore, Karnataka, India .
authors.forename: Ravindra Bhimrao
authors.initials: RB
authors.lastname: Kamble
authors.affiliation: Head of Department, Department of Radiology, Muscat, Oman .
authors.forename: Jayakumar
authors.initials: J
authors.lastname: Peruvumba N
authors.affiliation: Consultant Radiologist, Department of Radiology, Baltimore, Maryland .
authors.forename: Ravishankar
authors.initials: R
authors.lastname: Shivashankar
keywords: Brain; Mass lesions; Phosphorus spectroscopy