title: Effects of periodontal treatment on glycemic control in type 2 diabetic patients: a meta-analysis of randomized controlled trials.
abstract: The association between diabetes and inflammatory periodontal diseases has been studied extensively. However, there is a lack of robustness and homogeneity among studies describing effects of periodontal treatment on glycemic control. The aim of this study was to carry out a meta-analysis to understand whether periodontal treatment could improve glycemic control in type 2 diabetic patients. Electronic searches were carried out on MEDLINE, EMBASE and the Cochrane central register of controlled trials from 1980 to July 2012. Randomized controlled trials of periodontal therapy on glycemic control in diabetic patients with a minimum of 3 months of follow-up were included. Meta-analysis was carried out with 8 studies involving 515 participants using Stata 11.0 software. Our results showed that periodontal treatment could lead to a significant decrease in HbA1c level. The standardized mean difference between intervention groups and control groups was significant: 1.03% (95% confidence interval: 0.31% to 1.70%, P = 0.003) from baseline to 3 months, and 1.18% (95% confidence interval: 0.72% to 1.64%, P < 0.001) from baseline to 6 months. Periodontal treatment could lead to a non-significant decrease in fasting plasma glucose (FPG) levels from baseline to 3 months. The standardized mean difference between the intervention and the control group was 0.69 mg/dl (95% confidence interval: -0.27 mg/dl to 1.66 mg/dl, P = 0.158). Our analysis indicated that periodontal treatment could improve glycemic control in type 2 diabetic patients with periodontal diseases.
authors.affiliation: Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, PRC.
authors.forename: Qiu-ying
authors.initials: QY
authors.lastname: Sun
authors.forename: Mei
authors.initials: M
authors.lastname: Feng
authors.forename: Ming-zhi
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Yan-qing
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Ming-feng
authors.initials: MF
authors.lastname: Cao
authors.forename: Li-xiang
authors.initials: LX
authors.lastname: Bian
authors.forename: Qing-bo
authors.initials: QB
authors.lastname: Guan
authors.forename: Kai-lan
authors.initials: KL
authors.lastname: Song
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000628:therapy*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D010510:Periodontal Diseases / Q000097:blood / Q000150:complications / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human