title: Perspectives of induced pluripotent stem cells for cardiovascular system regeneration.
abstract: Induced pluripotent stem cells (iPSCs) hold great promise for basic research and regenerative medicine. They offer the same advantages as embryonic stem cells (ESCs) and moreover new perspectives for personalized medicine. iPSCs can be generated from adult somatic tissues by over-expression of a few defined transcription factors, including Oct4, Sox2, Klf4, and c-myc. For regenerative medicine in particular, the technology provides great hope for patients with incurable diseases or potentially fatal disorders such as heart failure. The endogenous regenerative potentials of adult hearts are extremely limited and insufficient to compensate for myocardial loss occurring after myocardial infarction. Recent discoveries have demonstrated that iPSCs have the potential to significantly advance future cardiovascular regenerative therapies. Moreover, iPSCs can be generated from somatic cells of patients with genetic basis for their disease. This human iPSC derivates offer tremendous potential for new disease models. This paper reviews current applications of iPSCs in cardiovascular regenerative medicine and discusses progress in modeling cardiovascular diseases using iPSCs-derived cardiac cells.
authors.affiliation: Institute of Histology and Embryology, Comenius University in Bratislava, 81108 Bratislava, Slovak Republic.
authors.forename: Mária
authors.initials: M
authors.lastname: Csöbönyeiová
authors.affiliation: Institute of Histology and Embryology, Comenius University in Bratislava, 81108 Bratislava, Slovak Republic.
authors.forename: Štefan
authors.initials: Š
authors.lastname: Polák
authors.affiliation: Institute of Medical Biology, Genetics and Clinical Genetics Faculty of Medicine, Comenius University in Bratislava, 81108 Bratislava, Slovak Republic lubos.danisovic@fmed.uniba.sk.
authors.forename: L'uboš
authors.initials: L
authors.lastname: Danišovič
mesh_terms: D000328:Adult; D002320:Cardiovascular Physiological Phenomena; D002454:Cell Differentiation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D000090062:Kruppel-Like Factor 4; D009203:Myocardial Infarction / Q000628:therapy; D012038:Regeneration; D033581:Stem Cell Transplantation
keywords: Induced pluripotent stem cells; cardiovascular disease; diseases modeling; regenerative medicine