title: Single high-dose vitamin D at birth corrects vitamin D deficiency in infants in Mexico.
abstract: This study examined the prevalence of vitamin D deficiency in mothers and infants in Tijuana, Mexico and determined the effect of a single oral dose of 50,000 IU vitamin D3 at birth on 25-hydroxyvitamin D (25[OH]D) levels during infancy. Healthy infants were randomized to receive vitamin D3 or placebo at birth. At birth 23% of infants were vitamin D deficient and 77% had vitamin D insufficiency (mean 25[OH]D level 18.9 ng/ml); 10% of mothers were vitamin D deficient and 61% were insufficient. Infants receiving vitamin D3 had higher 25(OH)D levels at two months (N = 29; 33.9 versus 24.2 ng/ml) and six months (N = 21; 36.5 versus 27.4 ng/ml). Exclusively breastfed infants had lower 25(OH)D levels at two months (14.9 versus 33.4 ng/ml). Vitamin D deficiency is common in infants and mothers in Tijuana, Mexico. A single dose of vitamin D3 at birth was safe and significantly increased 25(OH)D levels during infancy.
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases, University of California San Diego , La Jolla, CA , USA and.
authors.forename: Amaran
authors.initials: A
authors.lastname: Moodley
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Spector
mesh_terms: D000328:Adult; D001942:Breast Feeding; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000627:therapeutic use; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009035:Mothers; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D014815:Vitamins / Q000008:administration & dosage* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D
keywords: Host genetics; infant nutrition; vitamin D; vitamin D binding protein; vitamin D deficiency; vitamin D receptor