title: Saccade planning evokes topographically specific activity in the dorsal and ventral streams.
abstract: Saccade planning may invoke spatially-specific feedback signals that bias early visual activity in favor of top-down goals. We tested this hypothesis by measuring cortical activity at the early stages of the dorsal and ventral visual processing streams. Human subjects maintained saccade plans to (prosaccade) or away (antisaccade) from a spatial location over long memory-delays. Results show that cortical activity persists in early visual cortex at the retinotopic location of upcoming saccade goals. Topographically specific activity persists as early as V1, and activity increases along both dorsal (V3A/B, IPS0) and ventral (hV4, VO1) visual areas. Importantly, activity persists when saccade goals are available only via working memory and when visual targets and saccade goals are spatially disassociated. We conclude that top-down signals elicit retinotopically specific activity in visual cortex both in the dorsal and ventral streams. Such activity may underlie mechanisms that prioritize locations of task-relevant objects.
authors.affiliation: Center for Neural Science, and.
authors.forename: Golbarg T
authors.initials: GT
authors.lastname: Saber
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405.
authors.forename: Franco
authors.identifier: http://orcid.org/0000-0002-2469-0494
authors.initials: F
authors.lastname: Pestilli
authors.affiliation: Center for Neural Science, and Department of Psychology, New York University, New York, New York 10003, and clayton.curtis@nyu.edu.
authors.forename: Clayton E
authors.initials: CE
authors.lastname: Curtis
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*
keywords: antisaccade; fMRI; retinotopy; saccade; spatial cognition; working memory