title: Classification and grading of canine malignant mammary tumors.
abstract: Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included 37 tumors of mammary glands. Mammary tumors were carcinomas (n = 32) and sarcomas (n = 5). The carcinomas were classified as simple carcinoma 56.8% (n = 21), complex carcinoma 13.5% (n = 5), carcinoma arising from benign tumor 10.8% (n= 4) and special type of carcinoma 5.4% (n = 2). Out of 32 carcinomas studied, 37.5% (n = 12) grade I, 46.9% (n = 15) grade II and 15.6% (n = 5) grade III. This study demonstrated that the Elston and Ellis method of histological grading in canine mammary tumor is a reliable prognostic factor which is correlated with histopathological classification.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;
authors.forename: Abbas
authors.initials: A
authors.lastname: Tavasoly
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;
authors.forename: Hannaneh
authors.initials: H
authors.lastname: Golshahi
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahid Chamran, Ahvaz, Iran;
authors.forename: Annahita
authors.initials: A
authors.lastname: Rezaie
authors.affiliation: Department of Hematology, Iranian Blood Transfusion Organization, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farhadi
keywords: Classification; Dog; Grading; Mammary tumor