title: Effects of hydroxypyridine derivatives mexidol and emoxypin on the reparative processes in rabbit eye on the models of corneal epithelial defect and conjunctival ischemia.
abstract: Deepithelialization of the cornea (diameter 7 mm) was performed in rabbits and the rate of defect epithelialization was evaluated. Conjunctival ischemia was modeled by application of graduated alkaline burn. Antioxidant activity and content of nitrates and nitrites was measured in the tear fluid before and after burn by chemiluminescence and Griess methods, respectively. Emoxypin and mexidol promoted healing of corneal epithelial defect at the stage of epitheliocyte migration to the defect area and at the stage of their proliferation, respectively. After treatment with both agents, the area of conjunctival ischemia decreased more rapidly, but the efficiency of mexidol was higher. Antioxidant activity and content of products of NO metabolism in tear fluid decreased after burn. Mexidol, but not emoxypin, increased these parameters. Thus, mexidol and emoxypin have different effects on corneal epithelialization and conjunctival ischemia and effects of mexidol are more pronounced.
authors.affiliation: Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Chesnokova
authors.forename: O V
authors.initials: OV
authors.lastname: Beznos
authors.forename: T A
authors.initials: TA
authors.lastname: Pavlenko
authors.forename: A A
authors.initials: AA
authors.lastname: Zabozlaev
authors.forename: M V
authors.initials: MV
authors.lastname: Pavlova
mesh_terms: D000818:Animals; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology*; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy*; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D010847:Picolines / Q000494:pharmacology / Q000627:therapeutic use*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010847:Picolines; D011725:Pyridines; C014047:hydroxypyridines; C070020:emoxypine succinate; C009820:6-methyl-2-ethyl-3-hydroxypyridine