title: Markers of cardiac dysfunction in cognitive impairment and dementia.
abstract: Markers of cardiac dysfunction such as amino terminal pro-brain natriuretic peptide (NTpro-BNP) and high sensitivity cardiac troponin T (hs-cTnT) may be associated with dementia. However, limited data exist on their association with either pre-dementia stages, that is, cognitive impairment no dementia (CIND), or the burden of cerebrovascular diseases (CeVD).We therefore, examined the association of these biomarkers of cardiac dysfunction with CeVD in both CIND and dementia.A case-control study, with cases recruited from memory clinics and controls from memory clinics and community. All subjects underwent collection of blood samples, neuropsychological assessment, and neuroimaging. Subjects were classified as CIND and dementia based on clinical criteria whilst significant CeVD was defined as the presence of cortical infarcts and/or more than 2 lacunes and/or confluent white matter lesions in two regions of brain on Age-Related White Matter Changes Scale.We included a total of 35 controls (mean age: 65.9 years), 78 CIND (mean age: 70.2 years) and 80 cases with dementia (mean age: 75.6 years). Plasma concentrations of hs-cTnT were associated significantly with CeVD in both CIND (odds ratios [OR]: 9.05; 95% confidence interval [CI]: 1.64-49.79) and dementia (OR: 16.89; 95%CI: 2.02-142.67). In addition, NTpro-BNP was associated with dementia with CeVD (OR: 7.74; 95%CI: 1.23-48.58). These associations were independent of other vascular risk factors.In this study, we showed that plasma NTproBNP and hs-cTnT are associated with dementia and CIND, only when accompanied by presence of CeVD.
authors.affiliation: From the Memory, Ageing and Cognition Centre (MACC), National University Health System, Singapore (SH, YLC, MKI, SE, XX, JYC, NV, MKPL, CC); Department of Pharmacology, National University of Singapore, Singapore (SH, YLC, XX, JYC, MKPL, CC); Singapore Eye Research Institute, Singapore National Eye Center, Singapore (MKI); Department of Ophthalmology, National University of Singapore, Singapore (MKI); St. Luke's Hospital, Singapore (TBY, NV); Neuroscience Clinic, Raffles Hospital, Singapore (NV); and Cardiovascular Research Institute, National University Heart Centre, Singapore (AMR, JPCC).
authors.forename: Saima
authors.initials: S
authors.lastname: Hilal
authors.forename: Yuek Ling
authors.initials: YL
authors.lastname: Chai
authors.forename: Mohammad Kamran
authors.initials: MK
authors.lastname: Ikram
authors.forename: Sakktivel
authors.initials: S
authors.lastname: Elangovan
authors.forename: Tan Boon
authors.initials: TB
authors.lastname: Yeow
authors.forename: Xu
authors.initials: X
authors.lastname: Xin
authors.forename: Jun Yi
authors.initials: JY
authors.lastname: Chong
authors.forename: Narayanaswamy
authors.initials: N
authors.lastname: Venketasubramanian
authors.forename: Arthur Mark
authors.initials: AM
authors.lastname: Richards
authors.forename: Jenny P C
authors.initials: JPC
authors.lastname: Chong
authors.forename: Mitchell Kim Peng
authors.initials: MKP
authors.lastname: Lai
authors.forename: Christopher
authors.initials: C
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood*; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain