title: Benefits and limitations of multimodality imaging in the diagnosis of a primary cardiac lymphoma.
abstract: Primary cardiac tumors are far rarer than tumors metastatic to the heart. Angiosarcoma is the primary cardiac neoplasm most frequently detected; lymphomas constitute only 1% of primary cardiac tumors. We present the case of a 55-year-old woman with a recently diagnosed intracardiac mass who was referred to our institution for consideration of urgent orthotopic heart transplantation. Initial images suggested an angiosarcoma; however, a biopsy specimen of the mass was diagnostic for diffuse large B-cell lymphoma. The patient underwent chemotherapy rather than surgery, and she was asymptomatic 34 months later. We use our patient's case to discuss the benefits and limitations of multiple imaging methods in the evaluation of cardiac masses. Certain features revealed by computed tomography, cardiac magnetic resonance, and positron emission tomography can suggest a diagnosis of angiosarcoma rather than lymphoma. Cardiac magnetic resonance and positron emission tomography enable reliable distinction between benign and malignant tumors; however, the characteristics of different malignant tumors can overlap. Despite the great usefulness of multiple imaging methods for timely diagnosis, defining the extent of spread and the hemodynamic impact, and monitoring responses to treatment, we think that biopsy analysis is still warranted in order to obtain a correct histologic diagnosis in cases of suspected malignant cardiac tumors.
authors.forename: Prabhjot Singh
authors.initials: PS
authors.lastname: Nijjar
authors.forename: Sofia Carolina
authors.initials: SC
authors.lastname: Masri
authors.forename: Ashenafi
authors.initials: A
authors.lastname: Tamene
authors.forename: Helina
authors.initials: H
authors.lastname: Kassahun
authors.forename: Kenneth
authors.initials: K
authors.lastname: Liao
authors.forename: Uma
authors.initials: U
authors.lastname: Valeti
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D018618:Echocardiography, Doppler, Color; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor
keywords: Diagnostic imaging/methods; heart neoplasms/diagnosis/pathology/radiography; lymphoma/diagnosis/radiography; treatment outcome