title: Caspases come together over LPS.
abstract: Caspases are cellular executors, initiating cell death. In a recent study, Shi et al. report that caspases 4/5/11 are cytosolic LPS receptors, becoming activated through oligomerization upon interaction with LPS. These findings shed new light on the mechanisms underlying caspase-mediated pyroptosis, and have implications for the development of effective drugs to treat sepsis.
authors.affiliation: Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, 596 UCB, Boulder, CO 80309-0596, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Smith
authors.affiliation: Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, 596 UCB, Boulder, CO 80309-0596, USA; Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry & Biochemistry and the BioFrontiers Institute, University of Colorado Boulder, 596 UCB, Boulder, CO 80309-0596, USA; Center of Basic Molecular Science and Department of Chemistry, Tsinghua University, Beijing, 100082, China. Electronic address: hubert.yin@colorado.edu.
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D053471:Caspases, Initiator / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D020169:Caspases; D053471:Caspases, Initiator