title: Use of yttrium-90 hydroxyapatite radiosynovectomy as a primary modality of treatment in diffuse pigmented villonodular synovitis of the knee joint: A first case report.
abstract: Pigmented villonodular synovitis (PVNS) is a rare, relatively benign, intra-articular lesion characterized by a slowly progressive proliferation of synovial tissue. Knee is the most frequently involved joint. Localized and diffuse forms of synovial involvement were reported. In extensive diffuse cases, total synovectomy is needed, almost impossible to achieve. Hence, other treatment modalities such as intra-articular injection of yttrium-90 have been tried and shown to be effective in reducing the rate of local recurrence with "acceptable" joint damage. Radiosynovectomy is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. We describe the first case report of use of yttrium-90 hydroxyapatite particulates in a 33-year-old male who presented with diffuse PVNS of knee joint as a primary modality of treatment.
authors.affiliation: Department of Nuclear Medicine and Radionuclide Therapy, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Koramadai Karuppusamy
authors.initials: KK
authors.lastname: Kamaleshwaran
authors.affiliation: Department of Orthopedics, Ortho one Orthopedics Speciality Centre, Singanallur, Coimbatore, Tamil Nadu, India.
authors.forename: David
authors.initials: D
authors.lastname: Rajan
authors.affiliation: Department of Orthopedics, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Boopathi
authors.initials: B
authors.lastname: Krishnan
authors.affiliation: Department of Orthopedics, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Thirumalaisamy Subbaih
authors.initials: TS
authors.lastname: Gounder
authors.affiliation: Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Nuclear Medicine and Radionuclide Therapy, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Kalarickal
authors.affiliation: Department of Nuclear Medicine and Radionuclide Therapy, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Vyshakh
authors.initials: V
authors.lastname: Mohanan
authors.affiliation: Department of Nuclear Medicine and Radionuclide Therapy, Kovai Medical centre and Hospital Limited, Avanashi Road, Coimbatore, India.
authors.forename: Ajit Sugunan
authors.initials: AS
authors.lastname: Shinto
keywords: Knee joint; pigmented villonodular synovitis; radiosynovectomy; yttrium-90 hydroxyapatite