title: Primary cutaneous marginal IgG4 lymphoma and Rosai-Dorfman's disease coexisting in several lesions of the same patient.
abstract: We report the unique association of primary cutaneous marginal zone B-cell lymphoma and Rosai-Dorfman disease (RDD)-type histiocytic infiltrates involving the same lesions. The patient was an 82-year-old woman with 3 long-standing, well-circumscribed firm erythematous to brownish plaques on her left arm, right scapular area, and lumbosacral area. Histopathologic examination disclosed a dermal and subcutaneous nodular lymphoplasmacytic infiltrate with evidence of germinal center colonization and light-chain restriction and sheets of S-100 CD68-positive histiocytes with ample pale cytoplasm and occasional emperipolesis of lymphocytes. The neoplastic plasma cells expressed immunoglobulin (Ig) G4. A review of 14 examples of cutaneous RDD showed a substantial number of IgG4-positive cells in only 3 of them, and a review of 8 primary cutaneous marginal zone B-cell lymphomas disclosed only 2 with significant IgG4 expression. The coexistence of lymphomas and RDD has been rarely reported in the literature but only seldom involving the same lymph node and-to the best of our knowledge-never in the skin.
authors.affiliation: Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Madrid, Spain; ‡Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela, La Coruña, Spain; §Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; ¶Department of Pathology, Hospital Arnau de Vilanova, Valencia, Spain; ‖Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain; and **Department of Pathology, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
authors.forename: Salma
authors.initials: S
authors.lastname: Machan
authors.forename: Camino
authors.initials: C
authors.lastname: Medina
authors.forename: Socorro María
authors.initials: SM
authors.lastname: Rodríguez-Pinilla
authors.forename: José M
authors.initials: JM
authors.lastname: Suárez-Peñaranda
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Castro
authors.forename: Paula
authors.initials: P
authors.lastname: Molés
authors.forename: Celia
authors.initials: C
authors.lastname: Requena
authors.forename: Carles
authors.initials: C
authors.lastname: Saus
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
authors.forename: Carlos
authors.initials: C
authors.lastname: Santonja
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007074:Immunoglobulin G