title: Left temporal lobe epilepsy revealing left posterior cortical atrophy due to Alzheimer's disease.
abstract: Seizures can be an early symptom of Alzheimer's disease (AD) and can precede cognitive decline. Early epilepsy in AD can mimic transient epileptic amnesic syndrome (TEAS) or epileptic amnesic syndrome. We report the case of a patient who started a cerebrospinal fluid (CSF)-proven AD with partial seizures and TEAS that secondarily became a cortical posterior atrophy syndrome. CSF biomarkers showed a high amyloid production, amyloidopathy, and high level of total tau and p-Tau. This observation adds data to the complex AD-early epilepsy interactions and illustrates that atypical AD can cause a TEAS. Possible red flags for an underlying neurodegenerative process in TEAS are discussed.
authors.affiliation: Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar), France Laboratoire ICube, CNRS-Université de Strasbourg, France Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg/Service de Neurologie, Hospices Civils de Colmar, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cretin
authors.affiliation: Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar), France Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg/Service de Neurologie, Hospices Civils de Colmar, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Di Bitonto
authors.affiliation: Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar), France Laboratoire ICube, CNRS-Université de Strasbourg, France Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg/Service de Neurologie, Hospices Civils de Colmar, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Blanc
authors.affiliation: Centre Mémoire Ressousrces et Recherche (CMRR), CHU Besançon, Besançon, France Service de Neurologie, CHU Besançon, Besançon, France Centre Leenaards de la Mémoire, CHUV, Lausanne, Suisse.
authors.forename: Eloi
authors.initials: E
authors.lastname: Magnin
mesh_terms: D000544:Alzheimer Disease / Q000150:complications*; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000209:etiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon
keywords: Alzheimer's disease; mild cognitive impairment; posterior cortical atrophy; temporal lobe epilepsy; transient epileptic amnesic syndrome