title: Diffusion model to describe osteogenesis within a porous titanium scaffold.
abstract: In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 weeks. The cell activity is described through diffusion equations and regulated by the stress state of the structure. We compare our model to (i) histological observations and (ii) experimental data obtained from a mechanical test done on sacrificed animal. We show that our mechano-biological approach provides consistent numerical results and constitutes a useful tool to predict osteogenesis pattern.
authors.affiliation: a Arts et Métiers ParisTech, LBM , 151 bd de l'hôpital, 75013 Paris , France.
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.affiliation: a Arts et Métiers ParisTech, LBM , 151 bd de l'hôpital, 75013 Paris , France.
authors.forename: R
authors.initials: R
authors.lastname: Allena
authors.affiliation: a Arts et Métiers ParisTech, LBM , 151 bd de l'hôpital, 75013 Paris , France.|b Department of maxillofacial surgery , APHP - Pitie-Salpetriere University Hospital , University of Paris 6, 75013 Paris , France.
authors.forename: T
authors.initials: T
authors.lastname: Schouman
authors.affiliation: c Institut de recherche biomédicale des armées , 91223 Brétigny sur Orge , France.
authors.forename: S
authors.initials: S
authors.lastname: Frasca
authors.affiliation: c Institut de recherche biomédicale des armées , 91223 Brétigny sur Orge , France.
authors.forename: J M
authors.initials: JM
authors.lastname: Collombet
authors.affiliation: c Institut de recherche biomédicale des armées , 91223 Brétigny sur Orge , France.
authors.forename: X
authors.initials: X
authors.lastname: Holy
authors.affiliation: a Arts et Métiers ParisTech, LBM , 151 bd de l'hôpital, 75013 Paris , France.
authors.forename: P
authors.initials: P
authors.lastname: Rouch
mesh_terms: D000818:Animals; D004058:Diffusion; D005260:Female; D020342:Finite Element Analysis; D008334:Mandible / Q000187:drug effects; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D008954:Models, Biological; D010012:Osteogenesis / Q000187:drug effects*; D016062:Porosity; D019736:Prostheses and Implants; D012756:Sheep; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000494:pharmacology*
chemical_list: D014025:Titanium
keywords: bone scaffold; finite element method; in vivo test; mechanobiology; osteogenesis