title: A new paradigm for treatment of glaucoma.
abstract: Glaucoma is the leading irreversible cause of blindness in the world. We are developing a new image-guidance system to deliver a neuroprotective drug in a controlled release nanosponge. The system consists of a magnetically tracked image-guidance system, the nanosponge material and the drug. We have characterized the performance of each aspect in phantoms, animals and ex-vivo human tissue.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Galloway
authors.forename: Michael
authors.initials: M
authors.lastname: Delisi
authors.forename: Eva M
authors.initials: EM
authors.lastname: Harth
authors.forename: Louise A
authors.initials: LA
authors.lastname: Mawn
mesh_terms: D000818:Animals; D001766:Blindness / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D004724:Endoscopy / Q000379:methods*; D004867:Equipment Design; D005901:Glaucoma / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D018696:Neuroprotective Agents; D019047:Phantoms, Imaging; D011091:Polyesters; D012886:Skull / Q000473:pathology; D013552:Swine
chemical_list: D003692:Delayed-Action Preparations; D018696:Neuroprotective Agents; D011091:Polyesters