title: Mx GTPases: dynamin-like antiviral machines of innate immunity.
abstract: The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
authors.affiliation: Institute of Virology, University Medical Center Freiburg, Freiburg, Germany. Electronic address: otto.haller@uniklinik-freiburg.de.
authors.forename: Otto
authors.initials: O
authors.lastname: Haller
authors.affiliation: Institute of Virology, University Medical Center Freiburg, Freiburg, Germany. Electronic address: peter.staeheli@uniklinik-freiburg.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Staeheli
authors.affiliation: Institute of Virology, University Medical Center Freiburg, Freiburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Schwemmle
authors.affiliation: Institute of Virology, University Medical Center Freiburg, Freiburg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Kochs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000276:immunology*; D008958:Models, Molecular; D064547:Myxovirus Resistance Proteins / Q000737:chemistry* / Q000494:pharmacology / Q000502:physiology*; D009975:Orthomyxoviridae / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D010802:Phylogeny; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000276:immunology
chemical_list: D064547:Myxovirus Resistance Proteins
keywords: HIV-1; dynamin-like GTPase; influenza; innate immunity; interferon; primate evolution