title: Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity.
abstract: Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses.
authors.affiliation: Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea.
authors.forename: Yeon Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea.
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Choi
authors.affiliation: Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
authors.affiliation: Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea.
authors.forename: Dongwoo
authors.initials: D
authors.lastname: Khang
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D016503:Drug Delivery Systems; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007110:Immunity, Active / Q000187:drug effects*; D053758:Nanoparticles / Q000737:chemistry*; D000066970:Protein Corona / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001798:Blood Proteins; D000066970:Protein Corona
keywords: blood response; cytotoxicity; immunotoxicity; nanostructured biomaterials; protein corona