title: Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats.
abstract: The aim of this study was to examine effects of aluminum trichloride (AlCl3) on the bile acid secretion and hepatocyte apoptosis in rats. Forty male Wistar rats (5 weeks old) weighed 110-120 g were orally exposed to AlCl3 at doses of 0, 64.18 (1/20LD50), 128.36 (1/10LD50), and 256.72 (1/5LD50) mg/kg body weight in drinking water for 120 days. Each group had ten rats. The serum total bile acid (TBA) concentration, the early and total hepatocyte apoptosis indexes, and protein and mRNA expression of Bcl-2 and Bax were determined. The results showed that the serum TBA concentration, the early and total hepatocyte apoptosis indexes, and protein and mRNA expression of Bax increased, while protein and mRNA expression of Bcl-2 decreased in AlCl3-treated rats. The results indicate that AlCl3 disorders bile acid secretion and induces hepatocyte apoptosis in rats.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: She
authors.affiliation: Animal Husbandry and Veterinary Bureau of Zhucheng, Zhucheng, 262200, China.
authors.forename: Hansong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Institute of Special Animal and Plant Science of Chinese Academy of Agricultural Sciences, Changchun, 130112, China.
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Han
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Xia
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Chongsheng
authors.initials: C
authors.lastname: Bai
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. yanfeili200@126.com.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001647:Bile Acids and Salts / Q000097:blood / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D022781:Hepatocytes / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D001647:Bile Acids and Salts; D002712:Chlorides; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D000077410:Aluminum Chloride
keywords: AlCl3; Hepatocyte apoptosis; Rats; TBA