title: Oral signs of acute leukemia for early detection.
abstract: OBJECTIVE
  Systemic disease can manifest oral signs at an early phase, which may be crucial for the diagnosis and timing of treatment. This report describes two patients who presented with gingival enlargement as an early sign of acute leukemia.
  
  
  METHODS
  Two patients presented with oral symptoms including severe gingival enlargement. The progress of their symptoms was associated with underlying systemic disease.
  
  
  RESULTS
  The patients were transferred to the Department of Hematology and diagnosed with acute myelomonocytic leukemia. They received appropriate treatment and survived.
  
  
  CONCLUSIONS
  Gingival enlargement can be caused by underlying systemic diseases. Accurate diagnosis and timely referral are important for preventing a fatal situation. It must be emphasized that some oral signs and symptoms may be closely correlated with systemic diseases.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: Hyun-Chang
authors.identifier: 0000-0001-7695-1708
authors.initials: HC
authors.lastname: Lim
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. ; Department of Applied Life Science, BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: Chang-Sung
authors.identifier: 0000-0003-3902-1071
authors.initials: CS
authors.lastname: Kim
keywords: Dentist; Gingival hyperplasia; Leukemia