title: Genetic Epidemiology of Psoriasis.
abstract: Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8% across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease co-morbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.
authors.affiliation: University of California, San Francisco, Department of Dermatology, San Francisco, CA.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: University of California, San Francisco, Department of Dermatology, San Francisco, CA ; University of California, Irvine, School of Medicine, Irvine, CA.
authors.forename: Maya G
authors.initials: MG
authors.lastname: Debbaneh
authors.affiliation: University of California, San Francisco, Department of Dermatology, San Francisco, CA.
authors.forename: Wilson
authors.initials: W
authors.lastname: Liao
keywords: epidemiology; genetic; pathogenesis; prevalence; psoriasis