title: Artificial metalloenzymes derived from three-helix bundles.
abstract: Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.
authors.affiliation: Program in Chemical Biology, University of Michgan, Ann Arbor 48109, United States.
authors.forename: Alison G
authors.initials: AG
authors.lastname: Tebo
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor 48109, United States. Electronic address: vlpec@umich.edu.
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Pecoraro
mesh_terms: D003300:Copper / Q000378:metabolism; D015195:Drug Design; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D015032:Zinc / Q000378:metabolism
chemical_list: D004798:Enzymes; D008667:Metalloproteins; D003300:Copper; D015032:Zinc