title: Review of the treatment of liver hydatid cysts.
abstract: A review was carried out in Medline, LILACS and the Cochrane Library. Our database search strategy included the following terms: "hydatid cyst", "liver", "management", "meta-analysis" and "randomized controlled trial". No language limits were used in the literature search. The latest electronic search date was the 7(th) of January 2014.
  
  
  METHODS
  all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for analysis. Information from editorials, letters to publishers, low quality review articles and studies done on animals were excluded from analysis. Additionally, well-structured abstracts from relevant articles were selected and accepted for analysis. Standardized forms were designed for data extraction; two investigators entered the data on patient demographics, methodology, recurrence of HC, mean cyst size and number of cysts per group. Four hundred and fourteen articles were identified using the previously described search strategy. After applying the inclusion and exclusion criteria detailed above, 57 articles were selected for final analysis: one meta-analysis, 9 randomized clinical trials, 5 non-randomized comparative prospective studies, 7 non-comparative prospective studies, and 34 retrospective studies (12 comparative and 22 non-comparative). Our results indicate that antihelminthic treatment alone is not the ideal treatment for liver hydatid cysts. More studies in the literature support the effectiveness of radical treatment compared with conservative treatment. Conservative surgery with omentoplasty is effective in preventing postoperative complications. A laparoscopic approach is safe in some situations. Percutaneous drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the liver. Radical surgery with pre- and post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates.
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Gomez I Gavara
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: López-Andújar
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Belda Ibáñez
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Ramia Ángel
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Moya Herraiz
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Orbis Castellanos
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Pareja Ibars
authors.affiliation: Concepción Gomez i Gavara, Rafael López-Andújar, Ángel Moya Herraiz, Francisco Orbis Castellanos, Eugenia Pareja Ibars, Fernando San Juan Rodríguez, Hepatobiliopancreatic Surgery and Transplantation Unit, La Fe University Hospital, 46026 Valencia, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: San Juan Rodríguez
mesh_terms: D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects; D000977:Antiparasitic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D004322:Drainage / Q000009:adverse effects / Q000379:methods*; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000469:parasitology / Q000628:therapy*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D015766:Albendazole
keywords: Cystectomy; Echinococcosis; Hydatid; Liver Cyst; PAIR