title: Uncertainty quantification of the optimal stimulation area in an electro-stimulative hip revision system.
abstract: Electro-stimulative hip revision systems accelerate the bone growth around the implant and are capable of reducing the number of side effects such as aseptic implant loosening. A computational model was developed to determine the optimal electrode arrangement for such a system, which is currently under development. The optimization process depends on the electrical properties of bone material and the used bone substitute, which are subject to uncertainty in literature and its production process, respectively. To quantify the influence of these uncertain parameters on the optimal stimulation ratio (OSR), the computationally effective non-intrusive polynomial chaos technique was applied. The results indicate that the conductivity of bone substitute is most sensitive to the OSR, while its uncertainty was comparatively small compared to that of the uncertain parameters.
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.forename: Ulf
authors.initials: U
authors.lastname: Zimmermann
authors.forename: Ursula
authors.initials: U
authors.lastname: van Rienen
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D003198:Computer Simulation; D006801:Humans; D015233:Models, Statistical; D012086:Reoperation