title: Clinical and biochemical manifestations of Cushing's.
abstract: BACKGROUND
  Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality.
  
  
  METHODS
  This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particular focus on data from recently published literature.
  
  
  CONCLUSIONS
  Obesity and metabolic alterations, hypertension and cardio/cerebrovascular complications, hypercoagulability/thromboembolism, neuropsychiatric, muscle/skeletal and immune consequences remain the most challenging. Cardiovascular consequences and immunosuppression determine the main causes of death in Cushing's syndrome necessitating early intervention when possible.
authors.affiliation: Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Rd, Headington, Oxford, OX3 7LJ, UK.
authors.forename: Georgia
authors.initials: G
authors.lastname: Ntali
authors.forename: Ashley
authors.initials: A
authors.lastname: Grossman
authors.forename: Niki
authors.initials: N
authors.lastname: Karavitaki
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D000236:Adenoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D002423:Cause of Death; D015897:Comorbidity; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors