title: The unique characteristics of ON and OFF retinal ganglion cells: a modeling study.
abstract: Retinal ganglion cells (RGCs) demonstrate a large range of variation in their ionic channel properties and morphologies. These cell-specific properties are responsible for the unique way they process synaptic inputs. A cell-specific modeling approach allows us to examine the functional significance of regional membrane channel expression and cell morphology. ON and OFF RGC models based on accurate biophysics and realistic representation of morphologies were used to study the contribution of different ion channel properties and spatial structure of neurons to RGC electrical activity. Using this approach, morphologically-complex retinal neurons such as amacrine cells or RGCs can be modelled and their interactions and processing can be better understood.
authors.forename: Tianruo
authors.initials: T
authors.lastname: Guo
authors.forename: David
authors.initials: D
authors.lastname: Tsai
authors.forename: John W
authors.initials: JW
authors.lastname: Morley
authors.forename: Gregg J
authors.initials: GJ
authors.lastname: Suaning
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D000200:Action Potentials; D025042:Amacrine Cells / Q000502:physiology; D000818:Animals; D048430:Cell Shape; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008954:Models, Biological; D012165:Retinal Ganglion Cells / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D007473:Ion Channels