title: Locally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas.
abstract: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histogenesis and biologic behavior of UCOGCP remain controversial. Here, we report a case of UCOGCP that exhibited an invasive growth pattern involving infiltration of the adjacent bowel loop and portal vein, as well as superior mesenteric vein thrombosis. The patient underwent a distal pancreatectomy with splenectomy and partial colectomy, followed by four cycles of gemcitabine chemotherapy. No evidence of recurrence was detected after ten years. In addition to this case, clinical information on other UCOGCP cases reported in the English literature is summarized.
authors.affiliation: Hong-Qiao Gao, Yin-Mo Yang, Yan Zhuang, Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Hong-Qiao
authors.initials: HQ
authors.lastname: Gao
authors.affiliation: Hong-Qiao Gao, Yin-Mo Yang, Yan Zhuang, Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yin-Mo
authors.initials: YM
authors.lastname: Yang
authors.affiliation: Hong-Qiao Gao, Yin-Mo Yang, Yan Zhuang, Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Hong-Qiao Gao, Yin-Mo Yang, Yan Zhuang, Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001706:Biopsy; D018286:Carcinoma, Giant Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008641:Mesenteric Vascular Occlusion / Q000209:etiology; D008642:Mesenteric Veins; D009361:Neoplasm Invasiveness; D010010:Osteoclasts / Q000473:pathology*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine
keywords: Locally advanced; Pancreas; Undifferentiated carcinoma with osteoclast-like giant cells