title: Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis.
abstract: OBJECTIVE
  Studies on association between methylenetetrahydrofolate reductase gene (MTHFR) C677T gene polymorphism and ischemic stroke have shown conflicting results. We have conducted a meta-analysis to determine the precise association of the C677T polymorphism of MTHFR gene with risk of ischemic stroke.
  
  
  METHODS
  We searched electronic databases Medline, EMBASE, and Google Scholar (last search dated till August 2014). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from random or fixed-effects models were calculated. The methodological quality of included studies was determined by the quality assessment scale.
  
  
  RESULTS
  Thirty eight case-control studies fulfilled our inclusion criteria comprising 6310 patients and 8297 controls. The significant associations between MTHFR C677T genetic polymorphism and risk of ischemic stroke were observed in dominant (OR, 1·09; 95% CI, 1·06-1·12, P-value < 0·001) and recessive (OR, 1·31; 95% CI, 1·19-1·44, P-value < 0·001) inheritance models. In an Asian population, significant association between the MTHFR polymorphism and ischemic stroke was observed (dominant model: OR 1·36, 95% CI 1·23-1·49 and under recessive model OR, 1·29; 95% CI, 1·15-1·45). In the Caucasian population borderline, non-significant association was observed under dominant model of inheritance (OR, 1·05; 95% CI, 0·99-1·10) but significant association was observed under the recessive model of inheritance (OR, 1·33; 95% CI, 1·13-1·58).
  
  
  CONCLUSIONS
  The present study results suggest that MTHFR C677T genetic polymorphism is a probable risk of ischemic stroke.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.forename: Manya
authors.initials: M
authors.lastname: Prasad
authors.forename: Ram
authors.initials: R
authors.lastname: Sagar
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Yadav
authors.forename: Awadh Kishor
authors.initials: AK
authors.lastname: Pandit
authors.forename: Vidishaa Prasad
authors.initials: VP
authors.lastname: Jali
authors.forename: Abhishek
authors.initials: A
authors.lastname: Pathak
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D017594:Publication Bias; D020521:Stroke / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Cardiovascular disorder; Ischemic stroke,; Meta-analysis,; Methylenetetrahydrofolate reductase,; Polymorphism,