title: Effects of dietary selenium on host response to necrotic enteritis in young broilers.
abstract: The effects of dietary supplementation of young broiler chickens with an organic selenium (Se) formulation, B-Traxim Se, on experimental necrotic enteritis (NE) were studied. Chickens treated with three Se doses (0.25, 0.50, 1.00 mg/kg) from hatch were orally challenged with Eimeria maxima at 14 days of age followed by Clostridium perfringens to induce NE. Chickens fed with 0.50 mg/kg Se showed significantly increased body weights and antibody levels against NetB, and significantly reduced gut lesions compared with non-supplemented chickens. However, there were no significant differences in Eimeria oocyst shedding between the Se-treated and non-supplemented groups. Levels of IL-1β, IL-6, IL-8, iNOS, LITAF, TNFSF15, AvBD6, AvBD8, and AvBD13 transcripts were increased in the gut and spleen of at least one of the three Se-treated groups compared with the non-treated group. These results suggest that dietary supplementation of young broilers with Se might be beneficial to reduce the negative consequence of NE.
authors.affiliation: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong 266109, China; Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
authors.forename: Shouzhen
authors.initials: S
authors.lastname: Xu
authors.affiliation: Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA; National Academy of Agricultural Science, Rural Development Administration, 166, Nongsaengmyeong-ro, Iseo-myeon, Wanju-Gun, Jeollabuk-do, 565-851, Korea.
authors.forename: Sung-Hyen
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA. Electronic address: Hyun.Lillehoj@ars.usda.gov.
authors.forename: Hyun S
authors.initials: HS
authors.lastname: Lillehoj
authors.affiliation: Department of Animal Science and Technology, Chung-Ang University, Anseong 456-756, Korea.
authors.forename: Yeong Ho
authors.initials: YH
authors.lastname: Hong
authors.affiliation: InVivo NSA, Talhouët, 56250, St Nolff, France.
authors.forename: David
authors.initials: D
authors.lastname: Bravo
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002645:Chickens; D003015:Clostridium Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D003016:Clostridium perfringens / Q000502:physiology; D003048:Coccidiosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary; D060085:Coinfection / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004539:Eimeria / Q000502:physiology; D004751:Enteritis / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D054884:Host-Pathogen Interactions / Q000187:drug effects* / Q000276:immunology; D009336:Necrosis / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary; D011201:Poultry Diseases / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control*; D012643:Selenium / Q000494:pharmacology*
chemical_list: D012643:Selenium
keywords: Chicken; Cytokine; Necrotic enteritis; Selenium; β-defensin