title: Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris.
abstract: OBJECTIVE
  To investigate whether sodium tanshinone IIA silate (STS) as an add-on therapy to conventional treatment may provide additional benefits for patients with unstable angina pectoris (UAP) and is associated with changes in profiles of serum inflammatory factors.
  
  
  METHODS
  Eighty patients diagnosed with UAP were randomly divided into two groups for the 2-week treatment. The control group received conventional therapy, while the treatment group was given intravenous STS (0.06 mg in 250 mL, once daily) as an add-on therapy to the conventional medications. The therapeutic efficacy and changes in serum levels of several inflammatory cytokines, including monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), peroxisome proliferator-activated receptor (PPAR-γ), and high-sensitivity C-reactive protein (hs-CRP) from baseline were determined and compared between the two group.
  
  
  RESULTS
  The clinical symptoms of all patients in both groups were improved after treatment. The overall rate of effectiveness was 97.5% in the treatment group vs. 80.0% in the control group. Serum levels of MCP-1, TNF-α, and hs-CRP levels were significantly reduced in both groups (P<0.01), whereas the reduction was greater in patients receiving additional STS (P<0.05). PPAR-γ was significantly elevated in both groups (P<0.01).
  
  
  CONCLUSIONS
  STS in combination with conventional treatment may be associated with better outcomes in patients with UAP.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Long
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Yu
keywords: Unstable angina pectoris (UAP); high-sensitivity C-reactive protein (hs-CRP); monocyte chemotactic protein 1 (MCP-1); peroxisome proliferator-activated receptor (PPAR-γ); sodium tanshinone IIA silate (STS); tumor necrosis factor alpha (TNF-α)