title: Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes.
abstract: A new radiosynthetic protocol for the preparation of [(11)C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [(11)C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [(11)C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.
authors.affiliation: Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
authors.forename: Hong Geun
authors.initials: HG
authors.lastname: Lee
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Milner
authors.forename: Michael S
authors.initials: MS
authors.lastname: Placzek
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Hooker
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D007700:Kinetics; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013696:Temperature
chemical_list: D002250:Carbon Radioisotopes; D009570:Nitriles; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; C044646:phosphine