title: Neuroprotective and antiamnesic effect of erythropoietin derivatives after experimental ischemic injury of cerebral cortex.
abstract: Using the model of bilateral photothrombosis of the blood vessels in the prefrontal cortex we have shown that new hybrid proteins derived from recombinant human erythropoietin, carbamylated EPO-Fc and EPO-TR fusion proteins, injected intraperitoneally 1 h after ischemic injury contribute to restoration of passive avoidance response formed before photothrombotic injury and reduction in the volume of the ischemic focus. These data attest to nootropic and neuroprotective activities of these hybrid proteins. Carbamylated glycopeptide derivative ЕPO-TR exhibited prolonged neuroprotective properties.
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, romanovaga@mail.ru.
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: F M
authors.initials: FM
authors.lastname: Shakova
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: E E
authors.initials: EE
authors.lastname: Genrikhs
authors.forename: A M
authors.initials: AM
authors.lastname: Cheremnykh
authors.forename: T I
authors.initials: TI
authors.lastname: Kalinina
authors.forename: V L
authors.initials: VL
authors.lastname: Yurin
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism*; D004921:Erythropoietin / Q000737:chemistry*; D006801:Humans; D008297:Male; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D020521:Stroke / Q000188:drug therapy
chemical_list: D018696:Neuroprotective Agents; D004921:Erythropoietin