title: [Distribution of HIV-1 genotypes in China: a systematic review].
abstract: OBJECTIVE
  To provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China.
  
  
  METHODS
  A comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang (Chinese), CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites, period and objects for analyzing the distribution of HIV genotypes.
  
  
  RESULTS
  A total of 175 studies were included in this Meta-analysis, which contained 285 records. We found that the predominate genotypes in China were B' subtype, CRF01_AE, CRF07_BC and CRF08_BC, but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B' showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people.
  
  
  CONCLUSIONS
  The distribution of HIV-1 genotypes in Chinese people significantly changed, together with high complexity of the HIV-1 epidemics noticed in China.
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Su
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Huixin
authors.initials: H
authors.lastname: Liu
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Email: wangnbj@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
mesh_terms: D002681:China / Q000453:epidemiology; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans