title: Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma.
abstract: Although aggressive therapeutic regimen has been applied in the treatment of Glioblastoma (GBM), the prognosis of patients with GBM remains poor. Preclinical studies have demonstrated the efficacy of Suntinib in GBM both in vitro and in vivo. In this study, we showed that the cytotoxicity was enhanced by transfection with miR-145 mimic. In addition, we suggested that the enhanced cytotoxicity of Sunitinib by miR-145 mimic was mediated by inhibition of both P-gp and Bcrp.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huo
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University (CSU), Changsha, 410008, People's Republic of China. drjingchenlu@163.com.
authors.forename: Jingchen
authors.initials: J
authors.lastname: Lu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007211:Indoles / Q000633:toxicity*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011758:Pyrroles / Q000633:toxicity*; D000077210:Sunitinib
chemical_list: D020533:Angiogenesis Inhibitors; D007211:Indoles; C541010:MIRN145 microRNA, human; D035683:MicroRNAs; D011758:Pyrroles; D000077210:Sunitinib
keywords: GBM; Mir-145 mimic; Suntinib