title: Soluble epoxide hydrolase inhibitory activity of phenolic components from the rhizomes and roots of Gentiana scabra.
abstract: Two new (1 and 2) and seven known phenolic compounds were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their structures were identified by spectroscopic analysis and comparing with reported values. The inhibitory effects of each compound on soluble epoxide hydrolase (sEH) were evaluated. Among them, compounds 2, 6, and 9 potently inhibited sEH activity.
authors.affiliation: a School of Biotechnology , Yeungnam University , Gyeongsan , Korea.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jang Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Shim
authors.forename: Jin Yeul
authors.initials: JY
authors.lastname: Ma
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D030012:Gentiana / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*; D012995:Solubility
chemical_list: D004791:Enzyme Inhibitors; D010636:Phenols; D004851:Epoxide Hydrolases; D000432:Methanol
keywords: Gentiana scabra; Gentianaceae; phenolic compound; soluble epoxide hydrolase