title: N-acyl dopamine derivates as lead compound for implementation in transplantation medicine.
abstract: Conjugates of fatty acids with ethanolamine, amino acids or monoamine neurotransmitters occur widely in nature giving rise to so-called endocannabinoids. Anandamide and 2-arachidonoyl glycerol are the best characterized endocannabinoids activating both cannabinoid receptors (CB1 and CB2) and transient receptor potential vanilloid type 1 (TRPV1) channels (anandamide) or activating cannabinoid receptors only (2-arachidonoyl glycerol). TRPV1 is also activated by vanilloids, such as capsaicin, and endogenous neurolipins, e.g. N-arachidonoyl dopamine (NADA) and N-oleoyl dopamine (OLDA). Because donor dopamine treatment has shown to improve transplantation outcome in renal and heart recipients, this review will mainly focus on the biological activities of N-acyl dopamine derivates (NADD) as potential non-hemodynamic alternative for implementation in transplantation medicine. Hence the influence of NADD on transplantation relevant entities, i.e. cold inflicted injury, cytoprotection, I/R-injury, immune-modulation and inflammation will be summarized. The cytoprotective properties of endogenous endocannabinoids in this context will be briefly touched upon.
authors.affiliation: Department of Medicine, Nephrology, Endocrinology, Diabetology, Rheumatology; Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Wedel
authors.affiliation: Institute for Molecular and Cellular Biology, Mannheim University of Applied Sciences, Windeckstr. 98, 68163 Mannheim, Germany.
authors.forename: Prama
authors.initials: P
authors.lastname: Pallavi
authors.affiliation: Department of Medicine, Nephrology, Endocrinology, Diabetology, Rheumatology; Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
authors.forename: Eleni
authors.initials: E
authors.lastname: Stamellou
authors.affiliation: Department of Medicine, Nephrology, Endocrinology, Diabetology, Rheumatology; Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address: benito.yard@medma.uni-heidelberg.de.
authors.forename: Benito A
authors.initials: BA
authors.lastname: Yard
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D063388:Endocannabinoids / Q000378:metabolism*; D006084:Graft Rejection; D006085:Graft Survival; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods; D016377:Organ Transplantation; D012380:Role; D012680:Sensitivity and Specificity; D014181:Transplantation Immunology
chemical_list: D063388:Endocannabinoids; D002211:Capsaicin; D004298:Dopamine