title: Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management.
abstract: In the last years, several studies have recently evaluated the beneficial effects of red orange juice (Citrus sinensis (L.) Osbeck) and its active components in weight management and obesity. Moro orange is a cultivar of red orange, particularly rich in active compounds such as anthocyanins, hydroxycinnamic acids, flavone glycosides and ascorbic acid, which displays anti-obesity effects in in vitro and in vivo studies. In this clinical study, the effect of a Moro juice extract (Morosil(®), 400 mg/die) supplementation was evaluated in overweight healthy human volunteers for 12 weeks. Results showed that Moro juice extract intake was able to induce a significant reduction in body mass index (BMI) after 4 weeks of treatment (p < 0.05). Moreover, in subjects treated with Moro extract, body weight, BMI, waist and hip circumference were significantly different from the placebo group (p < 0.05). In conclusion, it could be suggested that the active compounds contained in Moro juice have a synergistic effect on fat accumulation in humans and Moro juice extract can be used in weight management and in the prevention of human obesity.
authors.affiliation: a Section of Physiology, Department of Bio-Medical Sciences , University of Catania , Viale Andrea Doria 6, 95125 Catania , Italy.
authors.forename: Venera
authors.initials: V
authors.lastname: Cardile
authors.affiliation: a Section of Physiology, Department of Bio-Medical Sciences , University of Catania , Viale Andrea Doria 6, 95125 Catania , Italy.
authors.forename: Adriana Carol Eleonora
authors.initials: AC
authors.lastname: Graziano
authors.affiliation: b Dipartimento di Chimica , "Sapienza" Università di Roma , Piazzale Aldo Moro 5, 00185 Roma , Italy.|c Dipartimento di Biologia Ambientale , "Sapienza" Università di Roma , Piazzale Aldo Moro 5, 00185 Roma , Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Venditti
mesh_terms: D000328:Adult; D015992:Body Mass Index; D032084:Citrus sinensis; D019587:Dietary Supplements; D004311:Double-Blind Method; D000067030:Fruit and Vegetable Juices; D006801:Humans; D008875:Middle Aged; D050177:Overweight / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D010936:Plant Extracts
keywords: Moro juice; obesity; red orange; weight management