title: Evaluation of peritoneal microbubble oxygenation therapy in a rabbit model of hypoxemia.
abstract: Alternative extrapulmonary oxygenation technologies are needed to treat patients suffering from severe hypoxemia refractory to mechanical ventilation. We previously demonstrated that peritoneal microbubble oxygenation (PMO), in which phospholipid-coated oxygen microbubbles (OMBs) are delivered into the peritoneal cavity, can successfully oxygenate rats suffering from a right pneumothorax. This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from 6.6 ±0.6 min for the saline controls to 12.2 ±3.0 min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provide extrapulmonary ventilation for rescue of severely hypoxic patients.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Legband
authors.forename: Jameel A
authors.initials: JA
authors.lastname: Feshitan
authors.forename: Mark A
authors.initials: MA
authors.lastname: Borden
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Terry
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology*; D007263:Infusions, Parenteral; D053208:Kaplan-Meier Estimate; D008297:Male; D045423:Microbubbles / Q000627:therapeutic use*; D010100:Oxygen / Q000008:administration & dosage* / Q000627:therapeutic use*; D010529:Peritoneal Cavity / Q000502:physiology*; D011674:Pulse; D011817:Rabbits
chemical_list: D010100:Oxygen