title: How uncomplicated total thyroidectomy could aggravate the laryngopharyngeal reflux disease?
abstract: Swallowing, voice disorders, throat discomfort and subjective neck discomfort are usually reported by patients with a known thyroid nodule and are correlated to nodular thyroid disease itself. Moreover, in endemic goitrous areas, total thyroidectomy (TT) is the most frequently performed surgical procedure. We are used to relate swallowing, voice and throat discomfort to the mechanical effects of nodular goiter or to thyroidectomy itself, but in both these cases the relationship between symptoms and the thyroid mass or its removal is not always clear or easily demonstrated. How can we explain the persistence of local neck symptoms after TT? And how can TT worsen the dysphagic or dysphonic disorders attributed to the goiter's effect over the surrounding structures? During these years, many articles have analyzed the relationship between the thyroid disease and the laryngopharyngeal reflux, finding more and more evidences of their consensuality, leading to important new management considerations and notable medico-legal implications; if the reason of local neck symptoms is not the thyroid disease, we have to study and specially cure the reflux disease, with specific test and drugs. Therefore, the aim of our study, relying on the published literature, was to investigate how, in demonstrated presence of reflux laryngopharyngitis in patients with nodular goiter and local neck symptoms before and after uncomplicated TT, the surgery could influence our anti-reflux mechanism analyzing the anatomical connection as well as the functional coordination; can we play a part in the post-operative persistence of swallowing and voice alterations and throat discomfort?
authors.affiliation: Dipartimento di Discipline Chirurgiche ed Oncologiche, University of Palermo, Palermo, Italy. alessia0414@gmail.com.|, Via Conciliazione 103, 22100, Como, Italy. alessia0414@gmail.com.
authors.forename: Alessia
authors.initials: A
authors.lastname: Cusimano
authors.affiliation: Dipartimento di Discipline Chirurgiche ed Oncologiche, University of Palermo, Palermo, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Macaione
authors.affiliation: Dipartimento di Discipline Chirurgiche ed Oncologiche, University of Palermo, Palermo, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Fiorentino
mesh_terms: D003679:Deglutition / Q000502:physiology; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D019468:Disease Management; D006044:Goiter, Nodular / Q000601:surgery*; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods; D014831:Voice / Q000502:physiology; D014832:Voice Disorders / Q000209:etiology / Q000503:physiopathology
keywords: Laryngopharyngeal reflux; Local neck symptoms; Nodular goiter; Thyroidectomy