title: Motor activity in young APPswe  + PS1/A246E bigenic mice as a predicting variable for memory decline.
abstract: Reports of individuality in rodent species have been a subject of debate in pharmacology and other fields. In the current study, APPswe  + PS1/A246E bigenic mice with Alzheimer's-like pathogenesis and wild-type controls were subdivided at 3 months of age into low, intermediate, and high responders in open-field activity. The mice were then evaluated longitudinally at 3 and 9 months for object recognition. Irrespective of genotype, mice with a high level of motor activity had better scores in object recognition. However, a significant correlation was established between open-field activity measured at 3 months of age and recognition memory measured at 9 months of age in the bigenic group only. These results indicate that motor activity in young mice with amyloid neuropathology may serve as a predicting variable for cognitive dysfunction in more mature mice.
authors.affiliation: Functional Analysis of Animal Behavior Platform, CHU de Québec Research Center, and Department of Molecular Medicine, Laval University, Québec City, Québec, Canada.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Filali
authors.forename: Robert
authors.initials: R
authors.lastname: Lalonde
mesh_terms: D000367:Age Factors; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000704:Analysis of Variance; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D011237:Predictive Value of Tests; D053764:Presenilin-1 / Q000235:genetics*; D021641:Recognition, Psychology / Q000502:physiology
chemical_list: D016564:Amyloid beta-Protein Precursor; C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer's disease; anxiety; bigenic mice; motor activity; object recognition