title: Value of 18F-FDG PET and PET/CT for evaluation of pediatric malignancies.
abstract: Successful management of solid tumors in children requires imaging tests for accurate disease detection, characterization, and treatment monitoring. Technologic developments aim toward the creation of integrated imaging approaches that provide a comprehensive diagnosis with a single visit. These integrated diagnostic tests not only are convenient for young patients but also save direct and indirect health-care costs by streamlining procedures, minimizing hospitalizations, and minimizing lost school or work time for children and their parents. (18)F-FDG PET/CT is a highly sensitive and specific imaging modality for whole-body evaluation of pediatric malignancies. However, recent concerns about ionizing radiation exposure have led to a search for alternative imaging methods, such as whole-body MR imaging and PET/MR. As we develop new approaches for tumor staging, it is important to understand current benchmarks. This review article will synthesize the current literature on (18)F-FDG PET/CT for tumor staging in children, summarizing questions that have been solved and providing an outlook on unsolved avenues.
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California; and.
authors.forename: Lebriz
authors.initials: L
authors.lastname: Uslu
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California; and.
authors.forename: Jessica
authors.initials: J
authors.lastname: Donig
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Stanford, California heiked@stanford.edu aquon@stanford.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Link
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California; and.
authors.forename: Jarrett
authors.initials: J
authors.lastname: Rosenberg
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California; and heiked@stanford.edu aquon@stanford.edu.
authors.forename: Andrew
authors.initials: A
authors.lastname: Quon
authors.affiliation: Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California; and heiked@stanford.edu aquon@stanford.edu.
authors.forename: Heike E
authors.initials: HE
authors.lastname: Daldrup-Link
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D009447:Neuroblastoma / Q000000981:diagnostic imaging; D010372:Pediatrics; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000000981:diagnostic imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: PET/CT; cancer staging; pediatric cancer imaging; pediatric lymphoma; pediatric oncology; pediatric sarcoma; positron emission tomography