title: Early gated SPECT adenosine myocardial perfusion imaging may influence the therapeutic management of patients with coronary artery disease.
abstract: OBJECTIVE
  The aim of the study was to investigate whether myocardial perfusion imaging at 15 min after injection (T15) is more accurate in detecting coronary artery disease than that at 45 min (T45).
  
  
  METHODS
  Two-day stress/rest 99mTc-tetrofosmin gated SPECT was performed at T15 and T45 in 50 patients. Coronary angiography was considered when poststress and resting images were discordant. Tracer washout rates were calculated for the myocardium, liver, and subdiaphragmatic region. Perfusion sum difference scores were derived using QPS software.
  
  
  RESULTS
  T15 and T45 were discordant in 18/50 (36%) patients. In 16/18 patients (89%) discordant deficits were more apparent at T15. A total of 13/16 patients underwent coronary angiography, of whom 12 had coronary artery disease. Poststress, but not resting, left ventricular ejection fraction was lower at T15 (P=0.02). Sum difference scores were higher at T15 [2.2 (1.9)] than at T45 [1.6 (1.7); P<0.05]. Tracer washout rates from the liver [46 (13.3)%] and subdiaphragmatic region [36 (21.3)%] were significant (P<0.0001), but there was no change in myocardial activity.
  
  
  CONCLUSIONS
  T15 detected more abnormalities than did T45. The reduction in left ventricular ejection fraction after stress may result from adenosine-induced poststunning at T15. Accordingly, the T15 protocol may be useful in the assessment of hibernating myocardium. Contrasting myocardial and hepatic washout rates may be attributable to differential ABC transporter expression.
authors.affiliation: Departments of aNuclear Medicine bCardiology, Royal Sussex County Hospital, Brighton and Sussex University Hospitals NHS Trust cBrighton Sussex Medical School, Brighton, UK.
authors.forename: Sabina
authors.initials: S
authors.lastname: Dizdarevic
authors.forename: Nitasha
authors.initials: N
authors.lastname: Singh
authors.forename: Sunil
authors.initials: S
authors.lastname: Nair
authors.forename: Adam
authors.initials: A
authors.lastname: de Belder
authors.forename: Nicola
authors.initials: N
authors.lastname: Ryan
authors.forename: Mark
authors.initials: M
authors.lastname: Aplin
authors.forename: Anil
authors.initials: A
authors.lastname: Vara
authors.forename: Rachael
authors.initials: R
authors.lastname: James
authors.forename: V Ralph
authors.initials: VR
authors.lastname: McCready
authors.forename: A Michael
authors.initials: AM
authors.lastname: Peters
mesh_terms: D000241:Adenosine; D000368:Aged; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D013318:Stroke Volume; D017256:Technetium Tc 99m Sestamibi; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin; D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine