title: Effect of dietary fiber on circulating C-reactive protein in overweight and obese adults: a meta-analysis of randomized controlled trials.
abstract: Previous studies suggested that dietary fiber intake may have a lowing effect on circulating C-reactive protein (CRP) level, a sensitive marker of inflammation, in overweight/obese adults with inconsistent results. A literature search was performed in April 2014 for related randomized controlled trials (RCTs) and meta-analysis was conducted. Meta-analysis including 14 RCTs showed that intervention with dietary fiber or fiber-rich food, compared with control, produced a slight, but significant reduction of 0.37 mg/L (95% CI -0.74, 0) in circulating CRP level among this population. Subgroup analyses showed that such a significant reduction was only observed after combining studies where the total fiber intake was 8 g/d higher in the intervention group than in the control group. No obvious heterogeneity and publication bias were found in the meta-analysis. In conclusion, this meta-analysis provides evidence that dietary fiber or food naturally rich in fiber has beneficial effects on circulating CRP level in overweight/obese adults.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University , Suzhou , China .
authors.forename: Jun
authors.initials: J
authors.lastname: Jiao
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Xu
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhang
authors.forename: Shufen
authors.initials: S
authors.lastname: Han
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qin
mesh_terms: D002097:C-Reactive Protein / Q000737:chemistry*; D016208:Databases, Factual; D004043:Dietary Fiber / Q000008:administration & dosage*; D006801:Humans; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity
chemical_list: D004043:Dietary Fiber; D002097:C-Reactive Protein
keywords: C-reactive protein; cardiovascular disease; dietary fiber; obesity; overweight