title: Efficacy of selective laser trabeculoplasty for normal tension glaucoma: 1 year results.
abstract: BACKGROUND
  Normal tension glaucoma (NTG) is commonly treated with anti-glaucoma medications. Recently, selective laser trabeculoplasty (SLT) has been demonstrated to lower the intraocular pressure (IOP) and medication use in NTG. The purpose of this study was to investigate the efficacy of a single session of SLT for NTG at 1 year.
  
  
  METHODS
  This prospective cohort study recruited NTG patients taking anti-glaucoma medication. Potential subjects were excluded if they had had previous glaucoma surgery or laser and also if intraocular surgery or additional SLT procedures were performed after the first treatment. All subjects underwent a 1-month washout. A 30% IOP reduction was set as the target IOP. A single session of SLT was performed to 360 degrees of the trabecular meshwork. At 1-month after SLT, medication was resumed to achieve the target IOP. The IOP was measured every 3 months, and the number of medications was recorded at 3, 6, and 12 months. Only the right eye was used for statistical analysis.
  
  
  RESULTS
  In 41 right eyes, the mean pre-study IOP was 14.3 ± 3.4 mmHg while on 1.5 ± 0.8 eye drops. The post-washout IOP was 16.2 ± 2.2 mmHg. A mean of 191.1 ± 26.3 SLT shots at 1.0 ± 0.07 mJ were applied. There was significant IOP reduction at all time intervals following SLT when compared to the post-washout IOP (P < 0.0001). The number of medications was significantly reduced at all time intervals following SLT when compared to the pre-study level (P < 0.0001). At 12 months, the mean IOP was 12.2 ± 2.2 mmHg while on 1.1 ± 0.9 eye drops.
  
  
  CONCLUSIONS
  A single session of SLT for NTG achieved an additional 15% IOP reduction while using 27% less medication at 1 year compared to pre-study levels.
  
  
  BACKGROUND
  The Clinical Trials Register of the University of Hong Kong HKCTR1847 The European Clinical Trials Database 2014-003305-15 (August 11, 2014) ( https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-003305-15 ).
authors.affiliation: Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong Kong. jackywylee@gmail.com.|Department of Ophthalmology, The University of Hong Kong, Kowloon, Hong Kong. jackywylee@gmail.com.
authors.forename: Jacky Wy
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Queen Mary Hospital, Kowloon, Hong Kong.
authors.forename: Wing Lau
authors.initials: WL
authors.lastname: Ho
authors.affiliation: Department of Ophthalmology, Queen Mary Hospital, Kowloon, Hong Kong.
authors.forename: Jonathan Ch
authors.initials: JC
authors.lastname: Chan
authors.affiliation: Department of Ophthalmology, The University of Hong Kong, Kowloon, Hong Kong.
authors.forename: Jimmy Sm
authors.initials: JS
authors.lastname: Lai
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D053685:Laser Therapy; D057066:Low Tension Glaucoma / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000503:physiopathology / Q000601:surgery*; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions