title: [Cutaneous angiosarcoma: new aspects].
abstract: Cutaneous angiosarcoma is an aggressive endothelial cell neoplasm with a high associated mortality. Reliable and confident diagnosis is necessary but frequently challenging due to the wide morphological spectrum and broad differential diagnosis of the disease. Furthermore, the final diagnosis often relies on immunohistochemical evidence of endothelial cell differentiation which is further complicated by the lack of sensitivity and specificity of conventional endothelial cell markers. The following article outlines the clinical and histological spectrum of cutaneous angiosarcoma with emphasis on novel findings relating to immunohistochemistry and molecular genetics in the context of the relevant differential diagnosis.
authors.affiliation: Abteilung für Pathologie, Western General Hospital und University of Edinburgh, Crewe Rd, EH4 2XU, Edinburgh, Schottland, t_brenn@yahoo.com.
authors.forename: T
authors.initials: T
authors.lastname: Brenn
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D003937:Diagnosis, Differential; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D025202:Molecular Diagnostic Techniques; D011237:Predictive Value of Tests; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000473:pathology*