title: Direct asymmetric dearomatization of 2-naphthols by scandium-catalyzed electrophilic amination.
abstract: Catalytic asymmetric aminative dearomatization of 1-substituted 2-naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral Sc(III)/pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective C-N bond-forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen-containing quaternary carbon stereocenters.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069 (China).
authors.forename: Jiang
authors.initials: J
authors.lastname: Nan
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Huayu
authors.initials: H
authors.lastname: Zheng
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zuo
authors.forename: Lei
authors.initials: L
authors.lastname: Hou
authors.forename: Huaiming
authors.initials: H
authors.lastname: Hu
authors.forename: Yaoyu
authors.initials: Y
authors.lastname: Wang
authors.forename: Xinjun
authors.initials: X
authors.lastname: Luan
mesh_terms: D000586:Amination; D002384:Catalysis; D008698:Mesylates / Q000737:chemistry; D009284:Naphthols / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008698:Mesylates; D009284:Naphthols; C012077:trifluoromethanesulfonic acid; C028405:2-naphthol; D012538:Scandium
keywords: amination; asymmetric catalysis; dearomatization; naphthol; scandium