title: Chemical constituents on the aerial parts of Artemisia selengensis and their IL-6 inhibitory activity.
abstract: Ten compounds, 1',3'-propanediol,2'-amino-1'-(1,3-benzodioxol-5-yl) (1), artanomaloide (2), canin (3), eupatilin (4), quercetin-3-O-β-D-glucoside-7-O-α-L-rhamnoside (5), 1,3-di-O-caffeoylquinic acid (6), isoquercitrin (7), pinoresinol-4-O-β-D-glucoside (8), scopolin (9), and isofraxidin-7-O-β-D-glucopyranoside (10) were isolated from the aerial parts of A. selengensis. The structures of compounds (1-10) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among them, compound 1 was isolated from this plant for the first time as a naturally occurring compound. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cells was also examined.
authors.affiliation: BK 21 Plus Project Team, College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-759, South Korea.
authors.forename: A Ryun
authors.initials: AR
authors.lastname: Kim
authors.forename: Hae Ju
authors.initials: HJ
authors.lastname: Ko
authors.forename: Md Anisuzzaman
authors.initials: MA
authors.lastname: Chowdhury
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Chang
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D015850:Interleukin-6 / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors