title: BBCA: Improving the scalability of *BEAST using random binning.
abstract: BACKGROUND
  Species tree estimation can be challenging in the presence of gene tree conflict due to incomplete lineage sorting (ILS), which can occur when the time between speciation events is short relative to the population size. Of the many methods that have been developed to estimate species trees in the presence of ILS, *BEAST, a Bayesian method that co-estimates the species tree and gene trees given sequence alignments on multiple loci, has generally been shown to have the best accuracy. However, *BEAST is extremely computationally intensive so that it cannot be used with large numbers of loci; hence, *BEAST is not suitable for genome-scale analyses.
  
  
  RESULTS
  We present BBCA (boosted binned coalescent-based analysis), a method that can be used with *BEAST (and other such co-estimation methods) to improve scalability. BBCA partitions the loci randomly into subsets, uses *BEAST on each subset to co-estimate the gene trees and species tree for the subset, and then combines the newly estimated gene trees together using MP-EST, a popular coalescent-based summary method. We compare time-restricted versions of BBCA and *BEAST on simulated datasets, and show that BBCA is at least as accurate as *BEAST, and achieves better convergence rates for large numbers of loci.
  
  
  CONCLUSIONS
  Phylogenomic analysis using *BEAST is currently limited to datasets with a small number of loci, and analyses with even just 100 loci can be computationally challenging. BBCA uses a very simple divide-and-conquer approach that makes it possible to use *BEAST on datasets containing hundreds of loci. This study shows that BBCA provides excellent accuracy and is highly scalable.
authors.forename: Théo
authors.initials: T
authors.lastname: Zimmermann
authors.forename: Siavash
authors.initials: S
authors.lastname: Mirarab
authors.forename: Tandy
authors.initials: T
authors.lastname: Warnow
mesh_terms: D001499:Bayes Theorem; D066264:Datasets as Topic; D049810:Genetic Speciation; D023281:Genomics / Q000379:methods*; D008957:Models, Genetic; D010802:Phylogeny