title: Fractionated electrograms and rotors detection in chronic atrial fibrillation using model-based clustering.
abstract: The identification of atrial fibrillation (AF) substrates is needed to improve ablation therapy guided by electrograms, although mechanisms that sustain AF are not fully understood. Detection of complex fractionated atrial electrograms (CFAE) is used for this purpose. Nonetheless, efficacy of this method is inadequate in the case of chronic AF. Recent hypothesis proposes the rotors as fibrillatory substrate. Novel approaches seek to relate CFAE with rotor; nevertheless, such methods are not able to identify the associated substrate. Furthermore, the patterns that characterize CFAE generated by rotors remain unknown. Thus, tracking of rotors is an unsolved issue. In this paper, we propose a non-supervised method to find patterns associated with fibrillatory substrates in chronic AF. We extracted two features based on local activation wave detection and one feature based on non-linear dynamics. Gaussian mixture model-based clustering was used to discriminate CFAE patterns. Resulting clusters are visualized in an electroanatomic map. We assessed the proposed method in a real database labeled according to the level of fractionation and in a simulated episode of chronic AF in which a rotor was detected. Our results indicate that the method proposed can separate different levels of fractionation in CFAE, and provide evidence that clustering can be used to locate the vortex of the rotors. Provided approach can support ablation therapy procedures by means of CFAE patterns discrimination.
authors.forename: A
authors.initials: A
authors.lastname: Orozco-Duque
authors.forename: S I
authors.initials: SI
authors.lastname: Duque
authors.forename: J P
authors.initials: JP
authors.lastname: Ugarte
authors.forename: C
authors.initials: C
authors.lastname: Tobon
authors.forename: D
authors.initials: D
authors.lastname: Novak
authors.forename: V
authors.initials: V
authors.lastname: Kremen
authors.forename: G
authors.initials: G
authors.lastname: Castellanos-Dominguez
authors.forename: J
authors.initials: J
authors.lastname: Saiz
authors.forename: J
authors.initials: J
authors.lastname: Bustamante
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology*; D016000:Cluster Analysis; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics