title: Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT.
abstract: In this work, the potential use of nanoparticles as contrast agents by using spectral domain optical coherence tomography (SD-OCT) in liver tissue was demonstrated. Gold nanoparticles (average size of 25 and 70 nm), were studied in human normal and cancerous liver tissues in vitro, respectively. Each sample was monitored with SD-OCT functional imaging for 240 min. Continuous OCT monitoring showed that, after application of gold nanoparticles, the OCT signal intensities of normal liver and cancerous liver tissue both increase with time, and the larger nanoparticles tend to produce a greater signal enhancement in the same type of tissue. The results show that the values of attenuation coefficients have significant differences between normal liver tissue and cancerous liver tissue. In addition, 25 nm gold nanoparticles allow higher penetration depth than 70 nm gold nanoparticles in liver tissues.
authors.affiliation: MOE Key Laboratory of Laser Life Science & 2 SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.forename: Huajiang
authors.initials: H
authors.lastname: Wei
authors.forename: Xiangping
authors.initials: X
authors.lastname: Ye
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.forename: Guoyong
authors.initials: G
authors.lastname: Wu
authors.forename: Hongqin
authors.initials: H
authors.lastname: Yang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.forename: Shusen
authors.initials: S
authors.lastname: Xie
authors.forename: Zhouyi
authors.initials: Z
authors.lastname: Guo
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D003287:Contrast Media; D006046:Gold