title: HIV treatment as prevention: contradictory perspectives from dynamic mathematical models.
abstract: The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission.
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, China ; School of Agroforestry and Medicine, The Open University of China, Beijing 100039, China.
authors.forename: Jing
authors.identifier: 0000-0002-5919-5485
authors.initials: J
authors.lastname: Wu
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, China.
authors.forename: Jessie L
authors.initials: JL
authors.lastname: Norris
authors.affiliation: Department of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Jia
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D008954:Models, Biological; D012309:Risk-Taking; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents