title: Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies.
abstract: Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT), due to their specific spatiotemporal selectivity and minimal invasiveness, have been widely investigated as alternative treatments of malignant diseases. Graphene and its derivatives not only have been used as carriers to deliver photosensitizers for PDT, but also as photothermal conversion agents (PTCAs) for PTT. Herein, we strategically designed and produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated graphene oxide (GO-PEG-DVDMS) for enhanced fluorescence/photoacoustic (PA) dual-modal imaging and combined PDT and PTT. The GO-PEG carrier drastically improves the fluorescence of loaded DVDMS via intramolecular charge transfer. Concurrently, DVDMS significantly enhances the near-infrared (NIR) absorption of GO for improved PA imaging and PTT. The cancer theranostic capability of the as-prepared GO-PEG-DVDMS was carefully investigated both in vitro and in vivo. This novel theranostics is well suited for fluorescence/PA dual-modal imaging and synergistic PDT/PTT.
authors.affiliation: Department of Radiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yan
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Jin
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Shaoliang
authors.initials: S
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Baozhong
authors.initials: B
authors.lastname: Shen
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000162:Acoustics; D000818:Animals; D001835:Body Weight; D006108:Graphite / Q000737:chemistry; D008027:Light; D051379:Mice; D008819:Mice, Nude; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D036103:Nanotechnology; D009368:Neoplasm Transplantation; D055095:Optics and Photonics; D010539:Permeability; D010777:Photochemistry / Q000379:methods*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared; D000068936:Theranostic Nanomedicine
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D017382:Reactive Oxygen Species; C586896:sinoporphyrin sodium; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D006108:Graphite