title: Comparison of mathematical models for red marrow and blood absorbed dose estimation in the radioiodine treatment of advanced differentiated thyroid carcinoma.
abstract: Metastatic and recurrent differentiated thyroid carcinoma is preferably treated with (131)I, whose administered activity is limited by red marrow (RM) toxicity, originally correlated by Benua to a blood absorbed dose higher than 2 Gy. Afterward a variety of dosimetric approaches has been proposed. The aim of this work is to compare the results of the Benua formula with the ones of other three blood and RM absorbed dose formulae. Materials and methods have been borrowed by the dosimetric protocol of the Italian Internal Dosimetry group and adapted to the routine of our centre. Wilcoxon t-tests and percentage differences have been applied for comparison purposes. Results are significantly different (p < 0.05) from each other, with an average percentage difference between Benua versus other results of -22%. The dosimetric formula applied to determine blood or RM absorbed dose may contribute significantly to increase heterogeneity in absorbed dose and dose-response results. Standardization should be a major objective.
authors.affiliation: Medical Physics Department, A.O. Ordine Mauriziano di Torino, Via Ferdinando Magellano 1, 10028 Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Miranti
authors.forename: A
authors.initials: A
authors.lastname: Giostra
authors.forename: E
authors.initials: E
authors.lastname: Richetta
authors.forename: E
authors.initials: E
authors.lastname: Gino
authors.forename: R E
authors.initials: RE
authors.lastname: Pellerito
authors.forename: M
authors.initials: M
authors.lastname: Stasi
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D002291:Carcinoma, Papillary / Q000473:pathology / Q000532:radiotherapy; D004912:Erythrocytes / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011874:Radiometry / Q000379:methods; D011879:Radiotherapy Dosage; D012044:Regression Analysis; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes