title: An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years.
abstract: BACKGROUND
  The epidemiology of type 1 diabetes mellitus may provide insights into the pathogenesis of the disease.
  
  
  OBJECTIVE
  The aim of this work was to characterize the trend of the incidence of type 1 diabetes mellitus in Romanian children aged from 0 to 17 years over a 10-year interval.
  
  
  METHODS
  Data regarding new cases were obtained from two sources: (1) The Romanian Childhood Diabetes Registry and (2) Records of the Medical Center "Cristian Serban", Buzias. The demographic data were retrieved from the National Institute for Statistics. The incidence was calculated for the age groups 0-4, 5-9, 10-14, and 15-17 years.
  
  
  RESULTS
  A total of 3196 new cases, aged below 18 years, were found by both the sources. There were significant differences between the groups (p=0.012), the mean incidence being highest in the age group 10-14 years (9.6/100,000/year, 95% CI 9-10.1) and lowest in children aged from 0 to 4 years (4.8/100,000/year, 95% CI 4.4-5.3). Boys were slightly more frequently affected than girls (p=0.038). The age and gender adjusted incidence of type 1 diabetes mellitus increased significantly (p<0.001) from 6.2/100,000/year (95% CI 5.5-6.9) in 2002 to 9.3/100,000/year (95% CI 8.4-10.3) in 2011. The raise in incidence was noticed in all age groups except for 15-17 years.
  
  
  CONCLUSIONS
  Romania is a country with an intermediate incidence of type 1 diabetes mellitus in children, which is slightly higher in boys than in girls. The incidence of type 1 diabetes mellitus increased continuously during the 10-year survey, with the exception of the oldest teens.
authors.forename: Viorel
authors.initials: V
authors.lastname: Serban
authors.forename: Stuart
authors.initials: S
authors.lastname: Brink
authors.forename: Bogdan
authors.initials: B
authors.lastname: Timar
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sima
authors.forename: Mihaela
authors.initials: M
authors.lastname: Vlad
authors.forename: Romulus
authors.initials: R
authors.lastname: Timar
authors.forename: Adrian
authors.initials: A
authors.lastname: Vlad
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology