title: Spontaneous mutual ordering of nucleic acids and proteins.
abstract: It is proposed that the prebiotic ordering of nucleic acid and peptide sequences was a cooperative process in which nearly random populations of both kinds of polymers went through a codependent series of self-organisation events that simultaneously refined not only the accuracy of genetic replication and coding but also the functional specificity of protein catalysts, especially nascent aminoacyl-tRNA synthetase "urzymes".
authors.affiliation: Department of Physics, University of Auckland, PB 92019, Auckland, 1142, New Zealand, p.wills@auckland.ac.nz.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Wills
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry* / Q000378:metabolism; D055162:Biocatalysis; D004735:Energy Transfer; D005815:Genetic Code; D007257:Information Theory; D008969:Molecular Sequence Data; D000069497:Origin of Life; D014176:Protein Biosynthesis; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry* / Q000378:metabolism; D012345:RNA, Transfer, Amino Acid-Specific / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D016337:RNA, Catalytic; D012333:RNA, Messenger; D012345:RNA, Transfer, Amino Acid-Specific; D000604:Amino Acyl-tRNA Synthetases