title: Effect of Iranian Propolis on Salivary Total Antioxidant Capacity in Gamma-irradiated Rats.
abstract: Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva containsantioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism iscompromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigatethe effect of propolis on salivary total antioxidant capacity in irradiated rats. Materials and methods. The study was conducted on 28 rats, 7-11 weeks of age (160±20 g), divided into four groups:saline with no radiation (S), saline and radiation (SR), propolis with no radiation (P) [400 mg/kg IP], propolis and radiation(PR) [400 mg/kg IP]. SP and PR were exposed to 15 Gy of gamma irradiation for 7 minutes and 39 seconds. The rats received intraperitoneal injections each day for 10 days, and their tongues and lips were daily examined for mucositis; salivasample were also taken three times on days 0, 6, and 10. Results. Mucositis incidence appeared to be delayed in the PR compared to the SR, and the severity was significantlyhigher in the SR compared to the PR. No significant alterations were observed in salivary antioxidant levels during the ex-periment, except the SR group in which a significant reduction was found. Conclusion. Propolis might reduce and delay radiation-induced mucositis in animal models; it might be able to prevent thereduction in salivary antioxidant levels in irradiated rats as well.
authors.affiliation: Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Aghel
authors.affiliation: Professor, Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Pouramir
authors.affiliation: Professor, Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Moghadamnia
authors.affiliation: Assistant Professor, Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Dariush
authors.initials: D
authors.lastname: Moslemi
authors.affiliation: Assistant Professor, Faculty of Dentistry, Mazandaran University of Medical Sciences, Babol, Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Molania
authors.affiliation: General Dental Practitioner.
authors.forename: Leila
authors.initials: L
authors.lastname: Ghassemi
authors.affiliation: Associate Professor, Dental Materials Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Motallebnejad
keywords: Antioxidant activity; propolis; radiation therapy; saliva