title: Real-time processing of fast-scan cyclic voltammetry (FSCV) data using a field-programmable gate array (FPGA).
abstract: This paper reports the hardware implementation of a digital signal processing (DSP) unit for real-time processing of data obtained by fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM), an electrochemical transduction technique for high-resolution monitoring of brain neurochemistry. Implemented on a field-programmable gate array (FPGA), the DSP unit comprises a decimation filter and an embedded processor to process the oversampled FSCV data and obtain in real time a temporal profile of concentration variation along with a chemical signature to identify the target neurotransmitter. Interfaced with an integrated, FSCV-sensing front-end, the DSP unit can successfully process FSCV data obtained by bolus injection of dopamine in a flow cell as well as electrically evoked, transient dopamine release in the dorsal striatum of an anesthetized rat.
authors.forename: Bardia
authors.initials: B
authors.lastname: Bozorgzadeh
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Covey
authors.forename: Byron A
authors.initials: BA
authors.lastname: Heidenreich
authors.forename: Paul A
authors.initials: PA
authors.lastname: Garris
authors.forename: Pedram
authors.initials: P
authors.lastname: Mohseni
mesh_terms: D000818:Animals; D002244:Carbon; D000077482:Carbon Fiber; D003199:Computer Systems; D004298:Dopamine / Q000032:analysis; D004558:Electric Stimulation; D004560:Electricity; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D004581:Electronics; D008297:Male; D008839:Microelectrodes; D017072:Neostriatum / Q000502:physiology; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D000077482:Carbon Fiber; D002244:Carbon; D004298:Dopamine