title: Defining the orphan functions of lysine acetyltransferases.
abstract: Long known for their role in histone acetylation, recent studies have demonstrated that lysine acetyltransferases also carry out distinct "orphan" functions. These activities impact a wide range of biological phenomena including metabolism, RNA modification, nuclear morphology, and mitochondrial function. Here, we review the discovery and characterization of orphan lysine acetyltransferase functions. In addition to highlighting the evidence and biological role for these functions in human disease, we discuss the part emerging chemical tools may play in investigating this versatile enzyme superfamily.
authors.affiliation: National Cancer Institute , Chemical Biology Laboratory, Frederick, Maryland 21702-1201, United States.
authors.forename: David C
authors.initials: DC
authors.lastname: Montgomery
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Sorum
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Meier
mesh_terms: D000105:Acetyl Coenzyme A / Q000737:chemistry / Q000378:metabolism; D000101:Acetyl-CoA C-Acetyltransferase / Q000737:chemistry / Q000378:metabolism; D000107:Acetylation; D000123:Acetyltransferases / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D063213:N-Terminal Acetyltransferase E / Q000737:chemistry / Q000378:metabolism; D063206:N-Terminal Acetyltransferases; D011499:Protein Processing, Post-Translational; D012323:RNA Processing, Post-Transcriptional; D050880:p300-CBP Transcription Factors / Q000737:chemistry / Q000378:metabolism; D000099224:p300-CBP-Associated Factor
chemical_list: D000105:Acetyl Coenzyme A; D000101:Acetyl-CoA C-Acetyltransferase; D000123:Acetyltransferases; D008239:Lysine; D063213:N-Terminal Acetyltransferase E; D063206:N-Terminal Acetyltransferases; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C522989:NAT10 protein, human; C506639:ACAT1 protein, human