title: Mechanisms of left-right asymmetry and patterning: driver, mediator and responder.
abstract: The establishment of a left-right (LR) organizer in the form of the ventral node is an absolute prerequisite for patterning the tissues on contralateral sides of the body of the mouse embryo. The experimental findings to date are consistent with a mechanistic paradigm that the laterality information, which is generated in the ventral node, elicits asymmetric molecular activity and cellular behaviour in the perinodal tissues. This information is then relayed to the cells in the lateral plate mesoderm (LPM) when the left-specific signal is processed and translated into LR body asymmetry. Here, we reflect on our current knowledge and speculate on the following: (a) what are the requisite anatomical and functional attributes of an LR organizer, (b) what asymmetric information is emanated from this organizer, and (c) how this information is transferred across the paraxial tissue compartment and elicits a molecular response specifically in the LPM.
authors.affiliation: Developmental Genetics Group, Graduate School of Frontier Bioscience, Osaka University Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamada
authors.affiliation: Embryology Unit, Children's Medical Research Institute and Sydney Medical School, University of Sydney New South Wales Australia.
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam