title: A poroviscohyperelastic model for numerical analysis of mechanical behavior of single chondrocyte.
abstract: The aim of this paper is to use a poroviscohyperelastic (PVHE) model, which is developed based on the porohyperelastic (PHE) model to explore the mechanical deformation properties of single chondrocytes. Both creep and relaxation responses are investigated by using finite element analysis models of micropipette aspiration and atomic force microscopy experiments, respectively. The newly developed PVHE model is compared thoroughly with the standard neo-Hookean solid and PHE models. It has been found that the PVHE can accurately capture both creep and stress relaxation behaviors of chondrocytes better than other two models. Hence, the PVHE is a promising model to investigate mechanical properties of single chondrocytes.
authors.affiliation: a School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology , Brisbane, Queensland , Australia.
authors.forename: Trung Dung
authors.initials: TD
authors.lastname: Nguyen
authors.affiliation: a School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology , Brisbane, Queensland , Australia.
authors.forename: Adekunle
authors.initials: A
authors.lastname: Oloyede
authors.affiliation: a School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology , Brisbane, Queensland , Australia.
authors.forename: Yuantong
authors.initials: Y
authors.lastname: Gu
mesh_terms: D001696:Biomechanical Phenomena; D019902:Chondrocytes / Q000502:physiology*; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D016062:Porosity; D011312:Pressure; D013314:Stress, Mechanical; D013997:Time Factors; D014783:Viscosity
keywords: biomechanics; chondrocyte; finite element analysis; porohyperelastic; poroviscohyperelastic