title: Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes.
abstract: Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in a streptozotocin-induced diabetic rat model. Rutin was orally administrated at a dose of 8 mg/kg body weight. Metabolic profiles, myocardial enzymes and oxidative stress were examined by biochemical tests. The expression levels of cellular proteins associated with apoptosis were measured by western blot analysis, while the levels of inflammatory factors were assessed by immunohistochemical analyses. Rats with DCM exhibited an abnormal metabolic profile, aberrant myocardial enzymes, elevation of oxidative stress markers, increased levels of inflammatory factors and enhanced apoptotic cell death. Notably, rutin was shown to protect and improve myocardial dysfunction, oxidative stress, apoptosis and inflammation in the hearts of the diabetic rats. In conclusion, these results indicated that rutin may have great therapeutic potential in the treatment of DCM, and possibly other cardiovascular disorders, by preventing oxidative stress, inflammation and cell death. However, further detailed studies are required to reveal the exact mechanisms underlying the protective effect of rutin.
authors.affiliation: Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250014, P.R. China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Ge
authors.affiliation: Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China.
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Kang
authors.affiliation: Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Zhe-Xun
authors.initials: ZX
authors.lastname: Lian
authors.affiliation: Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Chang-Yong
authors.initials: CY
authors.lastname: Zhou
keywords: antioxidants; diabetic cardiomyopathy; diabetic rats; rutin; streptozocin