title: ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.
abstract: Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid metabolism, a mediator of reverse-cholesterol transport, an acute satiety factor, a regulator of gastric function, and, finally, a modulator of blood glucose homeostasis. The purpose of this review is to update our current view of intestinal apoA-IV synthesis and secretion and the physiological roles of apoA-IV in lipid metabolism and energy homeostasis, and to underscore the potential for intestinal apoA-IV to serve as a therapeutic target for the treatment of diabetes and obesity-related disease.
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut alison.kohan@uconn.edu.
authors.forename: Alison B
authors.initials: AB
authors.lastname: Kohan
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and.
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Lo
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tso
mesh_terms: D000818:Animals; D001054:Apolipoproteins A / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002914:Chylomicrons / Q000378:metabolism; D004435:Eating; D004734:Energy Metabolism; D005247:Feeding Behavior; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D050356:Lipid Metabolism; D012528:Satiety Response; D015398:Signal Transduction
chemical_list: D001054:Apolipoproteins A; D002914:Chylomicrons; C022205:apolipoprotein A-IV; D005947:Glucose
keywords: apolipoprotein A-IV (apoA-IV); cardiovascular disease; chylomicron; diabetes; glucose homeostasis; intestinal lipid transport; lymph fistula mouse model; obesity; satiety