title: New hydrazones of ferulic acid: synthesis, characterization and biological activity.
abstract: The ferulic acid (4-hydroxy-3-methoxy-cinnamic acid) is a phenolic compound with important antioxidant effects and which nowadays is being extensively studied for his potential indications in inflammatory and neurodegenerative diseases, hypertension, atherosclerosis, etc.
  
  
  OBJECTIVE
  The synthesis of new ferulic acid compounds with potential antioxidant activity.
  
  
  METHODS
  The synthesis of the designed compounds was performed in several steps: (i) the obtaining of ferulic acid chloride by reacting of ferulic acid with thionyl chloride; (ii) the reaction between the ferulic acid chloride and hydrazine hydrate 98% to obtain the ferulic acid hydrazide; (iii) the condensation of ferrulic acid hydrazide with various benzaldehydes (2-hydroxy/3-hydroxy/4-hydroxy/2-nitro/3-nitro/4-nitro/2-methoxi/ 4-chloro/4-fluoro/4-bromo-benzaldehyde) resulting the correspond- ing hydrazones.
  
  
  RESULTS
  The structure of the synthesized compounds was confirmed by FT-IR spectroscopy and the evaluation of antioxidant potential was achieved by determining the total antioxidant capacity and reducing power.
  
  
  CONCLUSIONS
  In this study new hydrazones of ferulic acid have been synthesized, physic-chemical and spectral characterized. The evaluation of antioxidant potential using in vitro methods showed the favorable influence of the structural modulation on the antioxidant effects of ferulic acid.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Pharmaceutical Biotechnology.
authors.forename: Maria
authors.initials: M
authors.lastname: Wolszleger
authors.forename: Cătălina Daniela
authors.initials: CD
authors.lastname: Stan
authors.forename: Maria
authors.initials: M
authors.lastname: Apotrosoaei
authors.forename: Ioana
authors.initials: I
authors.lastname: Vasincu
authors.forename: Andreea
authors.initials: A
authors.lastname: Pânzariu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis*; D050197:Atherosclerosis / Q000188:drug therapy; D001547:Benzaldehydes / Q000138:chemical synthesis; D003373:Coumaric Acids / Q000138:chemical synthesis*; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013461:Sulfur Oxides / Q000138:chemical synthesis
chemical_list: D000975:Antioxidants; D001547:Benzaldehydes; D003373:Coumaric Acids; D006834:Hydrazines; D006835:Hydrazones; D013461:Sulfur Oxides; C029424:hydrazine; C023589:thionyl chloride; C004999:ferulic acid