title: Fluid-structure interaction analysis of bioprosthetic heart valves: Significance of arterial wall deformation.
abstract: We propose a framework that combines variational immersed-boundary and arbitrary Lagrangian-Eulerian (ALE) methods for fluid-structure interaction (FSI) simulation of a bioprosthetic heart valve implanted in an artery that is allowed to deform in the model. We find that the variational immersed-boundary method for FSI remains robust and effective for heart valve analysis when the background fluid mesh undergoes deformations corresponding to the expansion and contraction of the elastic artery. Furthermore, the computations presented in this work show that the arterial wall deformation contributes significantly to the realism of the simulation results, leading to flow rates and valve motions that more closely resemble those observed in practice.
authors.affiliation: Department of Mechanical Engineering, Iowa State University, 2025 Black Engineering, Ames, IA 50011, USA.
authors.forename: Ming-Chen
authors.initials: MC
authors.lastname: Hsu
authors.affiliation: Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, Stop C0200, Austin, TX 78712, USA.
authors.forename: David
authors.initials: D
authors.lastname: Kamensky
authors.affiliation: Department of Structural Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0085, La Jolla, CA 92093, USA.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Bazilevs
authors.affiliation: Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, Stop C0200, Austin, TX 78712, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Sacks
authors.affiliation: Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 East 24th St, Stop C0200, Austin, TX 78712, USA.
authors.forename: Thomas J R
authors.initials: TJ
authors.lastname: Hughes
keywords: Arbitrary Lagrangian–Eulerian formulation; Arterial wall deformation; Bioprosthetic heart valve; Fluid–structure interaction; Isogeometric analysis; Variational immersed-boundary method