title: Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems.
abstract: Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules. This kind of hybrid nanocomposite aims to combine the advantages of stimuli-responsive dendritic coatings, in order to regulate the drug release behaviour under different conditions and improve the biocompatibility and in vivo half-time circulation of the inorganic nanoparticles. Size, surface chemistry and shape are key nanocarrier properties to evaluate. Here, we have reviewed the most recent advances of NCDs in drug delivery systems, compared their behaviour with non-dendritic stabilized nanoparticles and highlighted their challenges and promising applications in the future.
authors.affiliation: Departamento de Fisicoquímica (INFIQC, CONICET-UNC), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, (5016) Córdoba, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Brunetti
authors.forename: L M
authors.initials: LM
authors.lastname: Bouchet
authors.forename: M C
authors.initials: MC
authors.lastname: Strumia
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity
chemical_list: D003287:Contrast Media; D050091:Dendrimers; D004337:Drug Carriers