title: Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N-H) α-ketoamides.
abstract: A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones with formamidine hydrochloride has been developed. This reaction represents a novel strategy for the synthesis of free (N-H) α-ketoamides. Based on the experimental results, a self-sequenced iodination/Kornblum oxidation/amidation/oxidation/decarbonylation mechanism was proposed.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chwuax@mail.ccnu.edu.cn.
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.forename: Kerong
authors.initials: K
authors.lastname: Ding
authors.forename: Anxin
authors.initials: A
authors.lastname: Wu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D007455:Iodine / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000577:Amides; D000578:Amidines; D007659:Ketones; C077922:formamidine; D007455:Iodine