title: Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings.
abstract: Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Olga
authors.initials: O
authors.lastname: Diakoumakou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Hatzigeorgiou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Gontoras
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece ; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Giannakopoulou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece.
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou