title: Intractable hyperkalemia due to nicorandil induced potassium channel syndrome.
abstract: Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP ) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy.
authors.affiliation: Department of Cardiac Anaesthesiology, Care Hospital, Bhubaneswar, Odisha, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Chowdhry
authors.forename: B B
authors.initials: BB
authors.lastname: Mohanty
mesh_terms: D000368:Aged; D015220:Calcium Channels / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D023921:Coronary Stenosis / Q000601:surgery; D003329:Coronary Vasospasm / Q000517:prevention & control; D003928:Diabetic Nephropathies / Q000150:complications; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D020108:Nicorandil / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D011188:Potassium / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D015220:Calcium Channels; D026902:Potassium Channel Blockers; D020108:Nicorandil; D011188:Potassium