title: Spinal cord atrophy in early Huntington's disease.
abstract: Despite evidence for spinal cord involvement, it remains unclear whether spinal cord atrophy exists in early Huntington's disease. We studied magnetic resonance images, covering both brain and upper cervical cord, in two cohorts of Huntington's patients and in one cohort of Alzheimer's patients. All cohorts included healthy controls comparable with regard to age and gender. We found significant spinal cord atrophy in both cohorts of Huntington's patients but not in the cohort of Alzheimer's patients. Furthermore, spinal cord atrophy correlated with motor symptoms indicating that spinal cord atrophy occurs in the clinical stages and does not result from abnormal development.
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Mühlau
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Engl
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Christine C
authors.initials: CC
authors.lastname: Boucard
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Statistics, Ludwig-Maximilians-University München Munich, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Schmidt
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Viola
authors.initials: V
authors.lastname: Biberacher
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Ophthalmology, University Hospital Hamburg Hamburg, Germany.
authors.forename: Isabel
authors.initials: I
authors.lastname: Görsch
authors.affiliation: TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Psychiatry, Klinikum rechts der Isar, Technische Universität München Munich, 81675, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.affiliation: TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Afra
authors.initials: A
authors.lastname: Wohlschläger
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.affiliation: Department of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
authors.forename: Adolph
authors.initials: A
authors.lastname: Weindl