title: The fundamental role of endothelial cells in hantavirus pathogenesis.
abstract: Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki Helsinki, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Hepojoki
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki Helsinki, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Vaheri
authors.affiliation: Department of Virology, Haartman Institute, University of Helsinki Helsinki, Finland.
authors.forename: Tomas
authors.initials: T
authors.lastname: Strandin
keywords: HCPS; HFRS; bunyavirus; endothelial dysfunction; hantavirus