title: Can nitric oxide induce migraine in normal individuals?
abstract: BACKGROUND
  For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks.
  
  
  CONCLUSIONS
  Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in normal individuals.
  
  
  CONCLUSIONS
  Experimental data show that normal individuals may develop a migraine-like attack and that the human data point to different ways of further developing existing animal and human models.
authors.affiliation: Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark.
authors.forename: Jes
authors.initials: J
authors.lastname: Olesen
authors.affiliation: Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark ashina@dadlnet.dk.
authors.forename: Messoud
authors.initials: M
authors.lastname: Ashina
mesh_terms: D004781:Environmental Exposure / Q000009:adverse effects*; D019317:Evidence-Based Medicine; D006801:Humans; D008881:Migraine Disorders / Q000139:chemically induced* / Q000378:metabolism*; D009569:Nitric Oxide / Q000009:adverse effects* / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide
keywords: Nitric oxide; animal models; human models; migraine; normal individuals