title: Plasmacytosis is a common immune signature in patients with MMN and CIDP and responds to treatment with IVIg.
abstract: B cells and antibodies are thought to be relevant in chronic immune neuropathies (CIN). We analysed peripheral B-cell homeostasis and effects of high-dose intravenous immunoglobulin (IVIg) on B-cell phenotypes in patients with multifocal motor neuropathy (n=22) and chronic inflammatory demyelinating polyneuropathy (n=8) by multi-color flow cytometry. At baseline, total B-cell numbers were decreased, but mature plasma cells were markedly elevated. IVIg rapidly prompted a decrease in plasma cell numbers and left B-cell homeostasis unchanged. Thus, expanded frequencies of plasma cells might be involved in CIN immunopathogenesis and are downscaled after clinically successful IVIg administration.
authors.affiliation: Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Korporal-Kuhnke
authors.affiliation: Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Haas
authors.affiliation: Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schwarz
authors.affiliation: Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Jarius
authors.affiliation: Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany. Electronic address: brigitte.wildemann@med.uni-heidelberg.de.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Wildemann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000276:immunology / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000188:drug therapy*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000188:drug therapy* / Q000276:immunology; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D016207:Cytokines; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
keywords: B lymphocytes; Chronic immune neuropathies; High-dose intravenous immunoglobulin; Plasma cells