title: A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy.
abstract: The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR experiments: it is soluble in neat [1-(13)C]pyruvic acid, insoluble in the dissolution transfer solvent and is effective as a polarizing agent in fast dissolution DNP-NMR applications, without the need for using glassing agents. Moreover, it enables a simple but effective in-line radical filtration to obtain hyperpolarized solutions of [1-(13)C]pyruvic acid free of radicals that offers a better polarization performance.
authors.affiliation: Institut de Ciència de Materials de Barcelona, (ICMAB-CSIC) Campus Universitari de Bellaterra, E-08193 Cerdanyola del Vallès, Spain. j.vidal@icmab.es.
authors.forename: J L
authors.initials: JL
authors.lastname: Muñoz-Gómez
authors.forename: E
authors.initials: E
authors.lastname: Monteagudo
authors.forename: V
authors.initials: V
authors.lastname: Lloveras
authors.forename: T
authors.initials: T
authors.lastname: Parella
authors.forename: J
authors.initials: J
authors.lastname: Veciana
authors.forename: J
authors.initials: J
authors.lastname: Vidal-Gancedo
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D019905:Benzyl Alcohol / Q000737:chemistry*; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000498:Allyl Compounds; D005609:Free Radicals; C416323:bis-diphenylene-phenyl-allyl; D019905:Benzyl Alcohol