title: Base-promoted oxidative C-H functionalization of α-amino carbonyl compounds under mild metal-free conditions: using molecular oxygen as the oxidant.
abstract: A base-mediated aerobic oxidation of the C-H bond adjacent to the N-atom of a secondary amine to form an imine intermediate under mild metal-free basic conditions has been developed. Accordingly, this new strategy has been successfully applied to the synthesis of various di-, tri-, and tetra-substituted α-aminocyclopentenones through a tandem aerobic oxidative [4 + 1] carbocyclization reaction of N-aryl α'-amino-α,β-unsaturated ketones as C4 1,4-dielectrophiles with active methylenes, including ethyl isocyanoacetate, nitroalkanes, and ethyl cyanoacetate, as C1 components.
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun, 130024, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Zhao
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu