title: Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation.
abstract: PTMS describes the presence of ≥3 cardiometabolic risk factors that include obesity, hypertension, dyslipidemia, and IR. The prevalence of the clustering of ≥3 cardiometabolic risk factors or central obesity has not been studied in pediatric LT recipients. Single-center, cross-sectional study.
  
  
  METHODS
  LT recipients 2-18 yr-old, at least one yr post-LT.
  
  
  METHODS
  recipients of liver retransplants or multivisceral transplants. Eighty-seven patients were identified. Median age was 9.8 yr (range 2-18), median time since LT was 6.9 yr (range 1-17). The most common indication for LT was biliary atresia (56%), and the most frequently used immunosuppressant was tacrolimus (80%). The prevalence of overweight and obesity was 21% and 5%, respectively. Central obesity affected 14%, hypertension 44%, IR 27%, low HDL 20%, and hypertriglyceridemia 39% of patients. The prevalence of ≥3 cardiometabolic risk factors was 19%. Fifty percent of the overweight/obese patients had ≥3 risk factors. Time since transplant, immunosuppression and renal function were not different between those with <3 or ≥3 risk factors. Clustering of cardiometabolic risk factors is prevalent in pediatric LT recipients, suggesting an increased risk of future CV events.
authors.affiliation: University of Toronto, Toronto, ON, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Dagher
authors.forename: Vicky L
authors.initials: VL
authors.lastname: Ng
authors.forename: Andrea
authors.initials: A
authors.lastname: Carpenter
authors.forename: Stephanie
authors.initials: S
authors.lastname: Rankin
authors.forename: Maria
authors.initials: M
authors.lastname: De Angelis
authors.forename: Yaron
authors.initials: Y
authors.lastname: Avitzur
authors.forename: Marialena
authors.initials: M
authors.lastname: Mouzaki
mesh_terms: D000293:Adolescent; D001656:Biliary Atresia / Q000601:surgery; D002318:Cardiovascular Diseases / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D017093:Liver Failure / Q000150:complications* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D056128:Obesity, Abdominal / Q000150:complications*; D050177:Overweight / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus
keywords: children; liver transplant; metabolic syndrome; outcome; waist circumference