title: Effectiveness of proton beam therapy on liver metastases of esophageal cancer: report of a case.
abstract: A 53-year-old man with multiple liver metastasis of esophageal cancer underwent four courses of chemotherapy. After four courses of chemotherapy, positron emission tomography showed progressive disease. Because it was difficult to control the cancer only by chemotherapy, we performed proton beam therapy (PBT) combined with chemotherapy. The irradiated parts were the primary tumor, liver metastases (S2/S4/S6), and mediastinal lymph nodes. The primary tumor including the mediastinal lymph nodes and the S2/S4/S6 metastases received proton beam irradiation at a total dose of 68.2 Gy in 31 fractions and 66.0 Gy in 30 fractions, respectively, according to tumor location. This resulted in a complete response as shown by positron emission tomography. In our experience, PBT exerted a curative effect on liver metastases of esophageal cancer. It is thought that PBT may be effective in the treatment of esophageal cancer. This is the first report about PBT for liver metastases of esophageal cancer.
authors.affiliation: 1 Department of Surgery 1 and Department of Radiology, Dokkyo Medical University Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Muroi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakajima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Satomura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Domeki
authors.forename: Masao
authors.initials: M
authors.lastname: Murakami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Akinori
authors.initials: A
authors.lastname: Takada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000627:therapeutic use; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D061766:Proton Therapy; D011859:Radiography; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: esophageal cancer; liver metastasis; proton beam therapy