title: Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives.
abstract: Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1',2'- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1',2'-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1',2'-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.
authors.affiliation: LAPLAMED, DEFAR, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, MG, Brasil.
authors.forename: Dênia A
authors.initials: DA
authors.lastname: Saúde-Guimarães
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Délio S
authors.initials: DS
authors.lastname: Raslan
authors.affiliation: Departamento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Egler
authors.initials: E
authors.lastname: Chiari
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Alaíde B
authors.initials: AB
authors.lastname: De Oliveira
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes; C526246:eremantholide C