title: Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is thought to result from a chronic or relapsing activation of the immune system in the GI tract. A growing body of evidence confirms the health benefits of dietary anthocyanins as plant-derived natural agents. The aim of this review is to provide an overview of several natural products rich in anthocyanins used worldwide for the treatment of IBD. Anthocyanins possess both protective and therapeutic functions in the management of IBD by alleviating oxidative stress processes, cytoprotective functions, downregulation of inflammatory cytokines and suppressing cellular signaling pathways of inflammatory processes. In conclusion, the consumption of anthocyanin-rich natural formulations must be promoted on the basis of their possible function in the prevention and treatment of gastrointestinal inflammatory disorders.
authors.affiliation: Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sodagari
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Farzaei
authors.forename: Roodabeh
authors.initials: R
authors.lastname: Bahramsoltani
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Abdolghaffari
authors.forename: Maryam
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000872:Anthocyanins / Q000008:administration & dosage* / Q000009:adverse effects; D000529:Complementary Therapies; D004032:Diet; D019587:Dietary Supplements / Q000009:adverse effects; D007887:Fabaceae; D005638:Fruit; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000872:Anthocyanins
keywords: anthocyanin; dietary supplementation; inflammation; inflammatory bowel disease; inflammatory cytokines; natural products