title: Task-induced modulation of intrinsic functional connectivity networks in the behaving rat.
abstract: While resting-state functional magnetic resonance imaging can probe intrinsic network connectivity in both human and rodent brain, behavioral modulation of these connectivity patterns has not yet been demonstrated in the rodent due to the requirements of immobilization or anesthesia for MRI scanning. To enable the effects of behavioral tasks on functional connectivity to be measured in freely moving, awake rats, implanted carbon paste electrodes (CPEs) were used to monitor low-frequency fluctuations of tissue oxygenation. Rats were implanted with CPEs in two nodes of the default mode network (DMN) and two nodes in a lateral cortical network, revealing amperometric oxygen correlation patterns consistent with imaging studies. Using a block design study where rats alternated between sustained periods of instrumental response and unscheduled spontaneous behavior, task-induced decreases in functional connectivity were observed between the DMN node pair, but not in the distinct lateral cortical network, demonstrating network-specific modulation of functional connectivity.
authors.affiliation: Centre for Cognitive Neuroscience, Eli Lilly and Company Limited, Windlesham, Surrey GU20 6PH, United Kingdom, lije@lilly.com.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Li
authors.affiliation: Centre for Cognitive Neuroscience, Eli Lilly and Company Limited, Windlesham, Surrey GU20 6PH, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Martin
authors.affiliation: Centre for Cognitive Neuroscience, Eli Lilly and Company Limited, Windlesham, Surrey GU20 6PH, United Kingdom.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Tricklebank
authors.affiliation: Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana 46285, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 46285.
authors.forename: Adam J
authors.identifier: http://orcid.org/0000-0002-9743-6171
authors.initials: AJ
authors.lastname: Schwarz
authors.affiliation: Centre for Cognitive Neuroscience, Eli Lilly and Company Limited, Windlesham, Surrey GU20 6PH, United Kingdom.
authors.forename: Gary
authors.initials: G
authors.lastname: Gilmour
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D063132:Connectome; D008297:Male; D009068:Movement; D009415:Nerve Net / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D011597:Psychomotor Performance; D051381:Rats; D017208:Rats, Wistar; D014851:Wakefulness
chemical_list: D010100:Oxygen
keywords: default mode network; functional connectivity; oxygen amperometry