title: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol as a urinary biomarker for monitoring of metofluthrin, a fluorine-containing pyrethroid, in exposed rats.
abstract: BACKGROUND
  A fluorine-containing pyrethroid metofluthrin is widely used recently in mosquito repellents.
  
  
  OBJECTIVE
  The urinary excretion kinetics of its metabolites was evaluated in rats to establish an optimal biomarker for monitoring metofluthrin exposure of the general population.
  
  
  RESULTS
  After metofluthrin had been administered intraperitoneally to rats, the urinary excretion kinetics of the major metofluthrin metabolites was evaluated by moment analysis. The urinary excretion amounts of 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol were estimated to be proportional to the absorption amounts over a wide exposure range.
  
  
  CONCLUSIONS
  Urinary 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol was considered to be an optimal biomarker for metofluthrin exposure.
authors.affiliation: Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi , Higashinari-ku, Osaka , Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D001592:Benzyl Alcohols / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003521:Cyclopropanes / Q000493:pharmacokinetics*; D005464:Fluorobenzenes / Q000493:pharmacokinetics* / Q000652:urine*; D007302:Insect Repellents / Q000493:pharmacokinetics*; D008297:Male; D017207:Rats, Sprague-Dawley
chemical_list: C000601999:4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol; D001592:Benzyl Alcohols; D015415:Biomarkers; D003521:Cyclopropanes; D005464:Fluorobenzenes; D007302:Insect Repellents; C492600:(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate
keywords: Biomonitoring; metabolism; mosquito repellent; toxicokinetics; urine