title: Acitretin-induced acral hemorrhagic lesions in Darier-White disease.
abstract: Darier-White disease (DD) is an autosomal-dominant inherited disease characterized by keratotic papules that are usually located in seborrheic areas. Systemic retinoids generally are first-line treatment in cases of diffuse DD. We report the case of an 84-year-old woman with a hypertrophic variant of DD with acral lesions. Oral retinoids (acitretin) were administered as a first treatment of DD, with good clinical results. After a few months, hemorrhagic vesicles developed on palmoplantar surfaces. Suspension of the therapy led to the disappearance of the cutaneous manifestations.
authors.forename: Elisa
authors.initials: E
authors.lastname: Zavattaro
authors.forename: Melissa
authors.initials: M
authors.lastname: Celasco
authors.forename: Giorgio
authors.initials: G
authors.lastname: Delrosso
authors.forename: Simona
authors.initials: S
authors.lastname: Ferri
authors.forename: Carlo
authors.initials: C
authors.lastname: Bornacina
authors.forename: Guido
authors.initials: G
authors.lastname: Valente
authors.forename: Federica
authors.initials: F
authors.lastname: Veronese
authors.forename: Nicola
authors.initials: N
authors.lastname: Fusco
authors.forename: Marisa
authors.initials: M
authors.lastname: Gariglio
authors.affiliation: Dermatology Unit, Department of Translational Medicine, University of Piemonte Orientale Amedeo Avogadro, Via Solaroli 17, 28110 Novara, Italy. enrico.colombo@med.unipmn.it.
authors.forename: Enrico
authors.initials: E
authors.lastname: Colombo
mesh_terms: D017255:Acitretin / Q000008:administration & dosage / Q000009:adverse effects*; D000369:Aged, 80 and over; D007644:Darier Disease / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin