title: A clinical and laboratory study evaluating the profile of cytokine levels in relapsing remitting and secondary progressive multiple sclerosis.
abstract: The main aim of the study was to evaluate levels of cytokines IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-alfa, TGB-beta1 and IFN-gamma in 30 patients with relapsing remitting (RRMS) compared to 30 secondary progressive multiple sclerosis (SPMS) in a peripheral blood sample. Statistical analysis showed significant higher levels of IL-17 and INF-gamma, which are cytokines with pro-inflammatory properties, and lower levels of TGF-beta1, a molecule with immunosuppressant activity, in RRMS compared to SPMS. These results underline the existence of a different cytokines dysregulation in RRMS compared to SPMS phases with higher pro-inflammatory activity in RRMS.
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy. Electronic address: lpasquali@med.unipi.it.
authors.forename: Livia
authors.initials: L
authors.lastname: Pasquali
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Lucchesi
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Pecori
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Metelli
authors.affiliation: Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pellegrini
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Iudice
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood* / Q000175:diagnosis*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D016207:Cytokines
keywords: Cytokines; IL-17; INF-gamma; Relapsing remitting multiple sclerosis; Secondary progressive multiple sclerosis; TGF-beta