title: Association of endothelial nitric oxide synthase gene polymorphism with the risk of Henoch-Schönlein purpura/Henoch-Schönlein purpura nephritis.
abstract: Association between endothelial nitric oxide synthase (eNOS) gene polymorphism and Henoch-Schönlein purpura (HSP)/Henoch-Schönlein purpura nephritis (HSPN) risk is still controversial. A meta-analysis was performed to evaluate the association between eNOS gene polymorphism and HSP/HSPN susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic database. Three articles were identified for the analysis of association between eNOS gene polymorphism and HSPN/HSP risk. eNOS G894T gene polymorphism was not associated with HSPN susceptibility and the risk of patients with HSP developing into HSPN. Interestingly, eNOS G894T T allele and GG genotype were associated with HSP susceptibility, but not the TT genotype. eNOS T786C TT genotype was associated with HSPN susceptibility, but not C allele and CC genotype. Furthermore, eNOS T786C gene polymorphism was not associated with HSP risk and the risk of patients with HSP developing into HSPN. In conclusion, eNOS T786C TT genotype was associated with and eNOS G894T T allele and GG genotype were associated with HSP susceptibility. However, more studies should be performed in the future.
authors.affiliation: Department of Nephrology, Central Hospital of Huizhou , Huizhou , China and.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zhong
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Zongpei
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000235:genetics; D009393:Nephritis / Q000209:etiology / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Henoch-Schönlein purpura; Henoch-Schönlein purpura nephritis; endothelial nitric oxide synthase; gene polymorphism; meta-analysis