title: [Atypical genesis of anterior ischemic optic neuropathy].
abstract: BACKGROUND
  This article presents a case of arteritic anterior ischemic optic neuropathy as a manifestation of granulomatosis with polyangiitis (GPA).
  
  
  METHODS
  A 52-year-old woman suffered acute unilateral vision loss. Besides a unilateral papillary edema, serological investigations revealed elevated inflammation parameters with a positive (cytoplasmic) anti-neutrophil cytoplasmic autoantibodies (c-ANCA) titer. In addition to the occurrence of pulmonary nodules and cavitary lesions this is indicative for the diagnosis of GPA.
  
  
  RESULTS
  Treatment with cyclophosphamide and prednisolone led to a rapid regression of inflammation parameters but no visual improvement occurred.
authors.affiliation: Augenklinik, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland, dutescumichael@googlemail.com.
authors.forename: R M
authors.initials: RM
authors.lastname: Dutescu
authors.forename: J P
authors.initials: JP
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Schroeter
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D017211:Treatment Failure; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents