title: [Clinical efficiency of short and long-term adjuvant therapy of chronic periodontal disease with azithromycin].
abstract: The purpose of the study was to compare the clinical response to two regimes of azithromycin use in the complex of non-surgical periodontal therapy. After initial periodontal therapy of chronic generalized periodontitis (CGP), 60 patients were randomly assigned to 3 groups. In group 2 and 3 azithromycin was administered: 500 mg 1 time per day, 3 days, and by 500 mg 1 time per day, 7 days, followed by 500 mg 1 time per week for 12 weeks. Clinical indexes were record before treatment and after 1, 3, 6 and 12 months. After 3 months 13 patients in group 1st had the exacerbation of CGP, and only 1 and 2 patients (p<0.05) in the 2nd and 3rd groups, respectively. After 12 months, significantly fewer patients on the 3rd group (as compared with the 1st (p=0.0015) and the 2nd (p=0.0040) had clinical exacerbation. Unscheduled visits were significantly less in the 3rd group as compared with the 1st (χ(2)=8.03; p=0.0046). The long-term adjunctive azithromycin results in a significantly clinical benefit of 80% patients for 1 year with satisfactory tolerance.
authors.affiliation: Vysshee gosudarstvennoe uchebnoe zavedenie Ukrainy "Ukrainskaia meditsinskaia stomatologicheskaia akademiia", Poltava, 36024.
authors.forename: T S
authors.initials: TS
authors.lastname: Nepokupnaia-Slobodianiuk
authors.affiliation: Vysshee gosudarstvennoe uchebnoe zavedenie Ukrainy "Ukrainskaia meditsinskaia stomatologicheskaia akademiia", Poltava, 36024.
authors.forename: P N
authors.initials: PN
authors.lastname: Skripnikov
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D055113:Chronic Periodontitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin