title: Mitochondrial proteases and protein quality control in ageing and longevity.
abstract: Mitochondria have been implicated in the ageing process and the lifespan modulation of model organisms. Mitochondria are the main providers of energy in eukaryotic cells but also represent both a major source of reactive oxygen species and targets for protein oxidative damage. Since protein damage can impair mitochondrial function, mitochondrial proteases are critically important for protein maintenance and elimination of oxidized protein. In the mitochondrial matrix, protein quality control is mainly achieved by the Lon and Clp proteases which are also key players in damaged mitochondrial proteins degradation. Accumulation of damaged macromolecules resulting from oxidative stress and failure of protein maintenance constitutes a hallmark of cellular and organismal ageing and is believed to participate to the age-related decline of cellular function. Hence, age-related impairment of mitochondrial protein quality control may therefore contribute to the age-associated build-up of oxidized protein and alterations of mitochondrial redox and protein homeostasis.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing - IBPS, F-75005 Paris, France; CNRS-UMR 8256, F-75005 Paris, France; INSERM U1164, F-75005 Paris, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Hamon
authors.affiliation: IPREM-LCABIE UMR 5254, 2 rue du président Angot, F-64000 Pau, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Bulteau
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing - IBPS, F-75005 Paris, France; CNRS-UMR 8256, F-75005 Paris, France; INSERM U1164, F-75005 Paris, France. Electronic address: bertrand.friguet@upmc.fr.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Friguet
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D006801:Humans; D008136:Longevity / Q000235:genetics* / Q000502:physiology*; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000502:physiology; D010447:Peptide Hydrolases / Q000235:genetics* / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics*; D011786:Quality Control
chemical_list: D024101:Mitochondrial Proteins; D010447:Peptide Hydrolases
keywords: Ageing; Clp proteases; Lon protease; Mitochondrial protein degradation; Protein maintenance; Protein oxidation