title: Thiamine Deficiency in a Developed Country: Acute Lactic Acidosis in Two Neonates Due to Unsupplemented Parenteral Nutrition.
abstract: Thiamine is a water-soluble vitamin implicated in several metabolic processes. Its deficiency, due to prolonged parenteral nutrition without adequate vitamin supplementation, can lead to multiorgan failure characterized by cardiovascular impairment and metabolic acidosis refractory to bicarbonate administration. Only thiamine administration allows the remission of symptoms. We report 2 preterm infants with acute thiamine deficiency due to prolonged parenteral nutrition without adequate vitamin supplementation.
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Salvatori
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Mondì
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy Fiammetta.piersigilli@yale.edu.
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Piersigilli
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
authors.forename: Irma
authors.initials: I
authors.lastname: Capolupo
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Pannone
authors.affiliation: Department of Metabolism, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
authors.forename: Carlo Dionisi
authors.initials: CD
authors.lastname: Vici
authors.affiliation: Department of Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Rizzo
authors.affiliation: Department of Neonatology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Dotta
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000209:etiology; D000140:Acidosis, Lactic / Q000209:etiology*; D001602:Beriberi / Q000209:etiology; D019049:Developed Countries; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology / Q000517:prevention & control; D007363:Intensive Care Units, Neonatal; D008297:Male; D010288:Parenteral Nutrition; D013831:Thiamine / Q000008:administration & dosage; D013832:Thiamine Deficiency / Q000209:etiology*
chemical_list: D013831:Thiamine
keywords: parenteral nutrition; preterm infant; shoshin beriberi; thiamine