title: Prevalence of human papillomavirus infection in Guangdong Province, China: a population-based survey of 78,355 women.
abstract: BACKGROUND
  The prevalence of human papillomavirus (HPV) infection and the distribution of different HPV genotypes vary greatly within different geographical and ethnic populations, especially in Asia. The HPV infection data based on regional population are extremely important for researchers to develop new efficient HPV screening assays and estimate the effect of vaccines on preventing from cervical cancer.
  
  
  METHODS
  A total of 78,355 women from Guangdong Province, China, whose ages were from 18 to 75 years were enrolled in this study. All epidemiological data were obtained by face-to-face interview. Cervical exfoliated cells were collected, and HPV-DNA test was conducted with the matrix-assisted laser desorption/ionization time-of flight mass spectrometry.
  
  
  RESULTS
  The overall HPV infection prevalence in the study population was 7.3%. The top 6 HPV genotypes were HPV16 (1.5%), HPV52 (1.2%), HPV58 (1.0%), HPV18 (0.7%), HPV45 (0.5%), and HPV6 (0.5%), accounting for 69.7% of all detected HPV infection types. Two peaks of HPV infection were detected in the population of old age group (>50; 9.6%) and young group (<25; 8.2%). Infection with single genotype HPV (6.2% in all; 85.7% in HPV-positive women) was more frequent than infection with multiple HPV (1.0% and 14.3% respectively). Results of multivariate logistic regression revealed that sexual active years, numbers of sexual partner, and numbers of pregnancy were risk factors of HPV infection.
  
  
  CONCLUSIONS
  This study provides useful epidemiological information on cervical HPV infection prevalence in general female population from Guangdong Province, China. In this population, HPV infection prevalence was 7.3%, and genotypes HPV16, HPV52, and HPV58 showed a relatively high prevalence.
authors.affiliation: From the *Department of Epidemiology, Medical School, Jinan University, Guangdong Province, China; †Family Planning Research Institute of Guangdong, Guangzhou, Guangdong Province, China; ‡Department of Parasitology, Medical School, Jinan University, Guangdong Province, China; and §Clinical Laboratory Center of the Beijing Genomics Institute (BGI), Shenzhen, Guangdong Province, China.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Jing
authors.forename: Xingming
authors.initials: X
authors.lastname: Zhong
authors.forename: Zeyan
authors.initials: Z
authors.lastname: Zhong
authors.forename: Weihuang
authors.initials: W
authors.lastname: Huang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zou
authors.forename: Chunxia
authors.initials: C
authors.lastname: Jing
authors.forename: Xiangcai
authors.initials: X
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D053918:Papillomavirus Vaccines; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D053918:Papillomavirus Vaccines