title: Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments.
abstract: OBJECTIVE
  To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments.
  
  
  METHODS
  A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, and 3D-OCT. The cpRNFL and the macular retinal nerve fiber layer (mRNFL), the ganglion cell layer+inner plexiform layer (GCLIPL), and the mRNFL+GCLIPL ganglion cell complex, GCC thicknesses were analyzed. The correlations between these values and the axial length or age were evaluated using a partial correlation analysis. These correlations were corrected using the axial length-related magnification effect.
  
  
  RESULTS
  All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the 3 OCT instruments were significantly correlated with age. The average cpRNFL thickness and GCC thickness measured using the Cirrus and RTVue, but not by the 3D-OCT, had a negative correlation with the axial length. The temporal quadrant cpRNFL thickness measured using the 3 instruments was positively correlated with the axial length. The magnification correction made the most correlations positive.
  
  
  CONCLUSIONS
  The average cpRNFL and GCC thicknesses measured using these 3 instruments decreased with age. The axial length affected the cpRNFL and GCC thicknesses as measured using the Cirrus and RTVue; this effect likely depended on the fundus area of analyses.
authors.affiliation: Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Ueda
authors.forename: Akiyasu
authors.initials: A
authors.lastname: Kanamori
authors.forename: Azusa
authors.initials: A
authors.lastname: Akashi
authors.forename: Mari
authors.initials: M
authors.lastname: Tomioka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D058452:Axial Length, Eye / Q000033:anatomy & histology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D012160:Retina / Q000033:anatomy & histology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*