title: [Clinical application of carbon nanoparticles in surgery for papillary thyroid carcinoma in young patients].
abstract: OBJECTIVE
  To investigate the number of dissected lymph nodes and the incidence of injury to parathyroid glands during surgery for papillary thyroid carcinoma (DTC) in young patients.
  
  
  METHODS
  This study collected clinicopathological data of 51 young patients with PTC. Of the 51 patients, 18 patients were classified into carbon nanoparticles group (CNP group) and 33 patients into traditional surgical group (TS group). The number of dissected lymph nodes and the incidence of injury to parathyroid glands were analyzed using Wilcoxon rank sum test and chi-square test.
  
  
  RESULTS
  There were 16 males and 35 females, with a male/female ratio of 1: 2.19. The age ranged from 14 to 29 (25 ± 3.9) years. There was no statistically significant difference in age, gender, T-classification, TNM stage and surgical procedures between two groups (P > 0.05). The total number of dissected lymph nodes in CNP group was higher than that in TS group (Z = -2.258, P < 0.05) . However, significant difference in the total number of metastatic lymph nodes between the two groups was not found (Z = -0.396, P > 0.05). In level VI, the detected lymph node number of group CNP was higher than that of TS group (Z = -2.461, P < 0.05) but there was no significant difference in the detected number of metastatic lymph nodes (Z = -1.396, P > 0.05) . The rates of injury to parathyroid gland were 5.5% in CNP group and 18.2% in TS group, respectively (χ(2) = 1.568, P > 0.05).
  
  
  CONCLUSIONS
  Carbon nanoparticles could be an effective lymph nodes tracer applying to PTC operation in young patients.
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Weiye
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Shaojian
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China. Email: guozhm@sysucc.org.cn.
authors.forename: Zhuming
authors.initials: Z
authors.lastname: Guo
mesh_terms: D002244:Carbon; D002277:Carcinoma / Q000628:therapy*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D053758:Nanoparticles; D037742:Nanotubes, Carbon; D010280:Parathyroid Glands; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000628:therapy*
chemical_list: D037742:Nanotubes, Carbon; D002244:Carbon