title: Recent advances in genome mining of secondary metabolites in Aspergillus terreus.
abstract: Filamentous fungi are rich resources of secondary metabolites (SMs) with a variety of interesting biological activities. Recent advances in genome sequencing and techniques in genetic manipulation have enabled researchers to study the biosynthetic genes of these SMs. Aspergillus terreus is the well-known producer of lovastatin, a cholesterol-lowering drug. This fungus also produces other SMs, including acetylaranotin, butyrolactones, and territram, with interesting bioactivities. This review will cover recent progress in genome mining of SMs identified in this fungus. The identification and characterization of the gene cluster for these SMs, as well as the proposed biosynthetic pathways, will be discussed in depth.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles, CA, USA.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Guo
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California Los Angeles, CA, USA ; Department of Chemistry, College of Letters, Arts, and Sciences, University of Southern California Los Angeles, CA, USA.
authors.forename: Clay C C
authors.initials: CC
authors.lastname: Wang
keywords: Aspergillus terreus; genome mining; natural products; secondary metabolites