title: T helper 2 polarization in senile erythroderma with elevated levels of TARC and IgE.
abstract: BACKGROUND
  Some cases of senile erythroderma tend to be diagnosed as senile atopic dermatitis (AD) based on elevated levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine (TARC). However, there are few studies that describe the detailed characteristics of senile erythroderma and senile AD.
  
  
  OBJECTIVE
  We examined the association of erythroderma with AD.
  
  
  METHODS
  In this retrospective observational study, 68 patients over 65 years of age who presented with erythroderma at Osaka University Hospital were enrolled. Patient data were collected through medical records and descriptive statistics.
  
  
  RESULTS
  47% of the patients were classified as having idiopathic erythroderma and 53% as having secondary erythroderma. In both idiopathic and secondary senile erythroderma patients, serum IgE and TARC levels were elevated. 84% of idiopathic erythroderma patients fulfilled the Japanese Dermatological Associations criteria for AD; however, only 4 patients were finally definitely diagnosed with senile AD.
  
  
  CONCLUSIONS
  Many senile erythroderma patients showed AD-like symptoms due to T helper 2 polarization.
authors.affiliation: Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Nakano-Tahara
authors.forename: Mika
authors.initials: M
authors.lastname: Terao
authors.forename: Megumi
authors.initials: M
authors.lastname: Nishioka
authors.forename: Shun
authors.initials: S
authors.lastname: Kitaba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D054414:Chemokine CCL17 / Q000097:blood*; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000276:immunology*; D003873:Dermatitis, Exfoliative / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor; C106230:CCL17 protein, human; D054414:Chemokine CCL17; D007073:Immunoglobulin E