title: Postprandial blood glucose control in type 1 diabetes for carbohydrates with varying glycemic index foods.
abstract: Treatment of type 1 diabetes consists of maintaining postprandial normoglycemia using the correct prandial insulin dose according to food intake. Nonetheless, it is hardly achieved in practice, which results in several diabetes-related complications. In this study we present a feedforward plus feedback blood glucose control system that considers the glycemic index of foods. It consists of a preprandial insulin bolus whose optimal bolus dose and timing are stated as a minimization problem, which is followed by a postprandial closed-loop control based on model predictive control. Simulation results show that, for a representative carbohydrate intake of 50 g, the present control system is able to maintain postprandial glycemia below 140 mg/dL while preventing postprandial hypoglycemia as well.
authors.forename: Shogo
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Claudia Cecilia Yamamoto
authors.initials: CC
authors.lastname: Noguchi
authors.forename: Eiko
authors.initials: E
authors.lastname: Furutani
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods*; D002241:Carbohydrates; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy; D004435:Eating; D038321:Glycemic Index; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D062407:Meals; D008962:Models, Theoretical; D019518:Postprandial Period
chemical_list: D001786:Blood Glucose; D002241:Carbohydrates; D007328:Insulin