title: Breaking up is hard to do: PI3K isoforms on the rebound.
abstract: In this issue of Cancer Cell, Schwartz and colleagues and Costa and colleagues demonstrate that inhibition of PI3Kα or PI3Kβ in cancer cells with hyperactivated PI3Kα or PI3Kβ, respectively, activates the other isoform, leading to a "rebound" of the PI3K activity through different compensation mechanisms.
authors.affiliation: Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5T 2M9, Canada; Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network and University of Toronto, ON M5T 2M9, Canada.
authors.forename: David W
authors.initials: DW
authors.lastname: Cescon
authors.affiliation: Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5T 2M9, Canada.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gorrini
authors.affiliation: Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5T 2M9, Canada. Electronic address: tmak@uhnresearch.ca.
authors.forename: Tak W
authors.initials: TW
authors.lastname: Mak
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002867:Chromones / Q000494:pharmacology*; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
chemical_list: C578518:2-(1-(7-methyl-2-morpholin-4-yl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl)ethylamino)benzoic acid; C000595972:AZD8186; D000814:Aniline Compounds; D002867:Chromones; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D011744:Pyrimidinones; D013844:Thiazoles; D062367:ortho-Aminobenzoates; C585539:Alpelisib; D058534:Class I Phosphatidylinositol 3-Kinases; D051059:PTEN Phosphohydrolase