title: Tenascin C levels in patients with mild and severe preeclampsia.
abstract: OBJECTIVE
  To determine the serum tenascin-C (TN-C) levels in cases with mild and severe preeclampsia.
  
  
  METHODS
  Pregnant women were divided into three groups, namely healthy pregnants (Group 1, n = 20), pregnants with mild preeclampsia (Group 2, n = 20) and pregnants with severe preeclampsia (Group 3, n = 20). The groups were formed so as to match each other in terms of gestational week. From each pregnant woman, pre- and post-delivery blood samples were obtained to measure serum TN-C levels. The data were evaluated using the Kruskall-Wallis variance analysis. For the obtained values of p < 0.05, the groups were compared in pairs. A p value of < 0.017 was accepted as significant.
  
  
  RESULTS
  In Groups 1, 2 and 3, the prepartum TN-C levels were 5.02 ± 0.4 µg/ml, 12.8 ± 2.9 µg/ml and 33.8 ± 11.7 µg/ml, and in the postpartum TN-C levels were 4.7 ± 0.1 µg/ml, 11.7 ± 1.8 µg/ml and 50.6 ± 33.8 µg/ml, respectively. There was a significant difference between the groups in terms of the prepartum and postpartum TN-C levels (p < 0.017, Mann-Whitney U [MWU] test). There was also a significant difference in the prepartum TN-C levels between Groups 2 and 3 (p < 0.017, MWU test).
  
  
  CONCLUSIONS
  The prepartum and postpartum TN-C levels were significantly higher in mild and severe preeclampsia than those in healthy pregnants.
authors.affiliation: a Department of Obstetrics and Gynecology , Firat Medical Center, School of Medicine, Firat University , Elazig , Turkey .
authors.forename: Ugur
authors.initials: U
authors.lastname: Orak
authors.affiliation: b Department of Obstetric and Gynecology , Special Medical Park Hospital , Elazig , Turkey .
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.affiliation: a Department of Obstetrics and Gynecology , Firat Medical Center, School of Medicine, Firat University , Elazig , Turkey .
authors.forename: Salih Burcin
authors.initials: SB
authors.lastname: Kavak
authors.affiliation: c Department of Anesthesia and Reanimation , and.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Demirel
authors.affiliation: a Department of Obstetrics and Gynecology , Firat Medical Center, School of Medicine, Firat University , Elazig , Turkey .
authors.forename: Remzi
authors.initials: R
authors.lastname: Atilgan
authors.affiliation: d Department of Biochemistry , Firat University , Elazig , Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: a Department of Obstetrics and Gynecology , Firat Medical Center, School of Medicine, Firat University , Elazig , Turkey .
authors.forename: Ekrem
authors.initials: E
authors.lastname: Sapmaz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D019063:Tenascin / Q000097:blood*
chemical_list: D019063:Tenascin
keywords: Cytokine; preeclampsia; tenascin-C