title: Three-dimensional motion correction using speckle and phase for in vivo computed optical interferometric tomography.
abstract: Over the years, many computed optical interferometric techniques have been developed to perform high-resolution volumetric tomography. By utilizing the phase and amplitude information provided with interferometric detection, post-acquisition corrections for defocus and optical aberrations can be performed. The introduction of the phase, though, can dramatically increase the sensitivity to motion (most prominently along the optical axis). In this paper, we present two algorithms which, together, can correct for motion in all three dimensions with enough accuracy for defocus and aberration correction in computed optical interferometric tomography. The first algorithm utilizes phase differences within the acquired data to correct for motion along the optical axis. The second algorithm utilizes the addition of a speckle tracking system using temporally- and spatially-coherent illumination to measure motion orthogonal to the optical axis. The use of coherent illumination allows for high-contrast speckle patterns even when imaging apparently uniform samples or when highly aberrated beams cannot be avoided.
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Shemonski
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Shawn S
authors.initials: SS
authors.lastname: Ahn
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Yuan-Zhi
authors.initials: YZ
authors.lastname: Liu
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Fredrick A
authors.initials: FA
authors.lastname: South
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: P Scott
authors.initials: PS
authors.lastname: Carney
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, Illinois 61801, USA ; Departments of Bioengineering, University of Illinois at Urbana-Champaign 1304 West Springfield Avenue, Urbana, Illinois 61801, USA ; Department of Internal Medicine, University of Illinois at Urbana-Champaign, 506 South Mathews Avenue, Urbana, Illinois 61801, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boppart
keywords: (100.5090) Phase-only filters; (110.3010) Image reconstruction techniques; (110.3175) Interferometric imaging; (110.3200) Inverse scattering; (110.4280) Noise in imaging systems; (110.4500) Optical coherence tomography