title: Tuning macrocycles to design 'turn-on' fluorescence probes for manganese(II) sensing in live cells.
abstract: We tune the coordination environment of macrocyclic ligands to design two novel fluorescence sensors for Mn(2+). The BODIPY-based Mn(2+) sensor M1 affords an excellent, 52 fold, fluorescence 'turn-on' response despite the paramagnetic nature of Mn(2+). The lipophilic probe is cell-permeable and confocal imaging demonstrates that the sensor distinctly detects Mn(2+) within live cells.
authors.affiliation: Department of Chemical Sciences, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Colaba, Mumbai-400005, India. ankona@tifr.res.in.
authors.forename: Subha
authors.initials: S
authors.lastname: Bakthavatsalam
authors.forename: Anindita
authors.initials: A
authors.lastname: Sarkar
authors.forename: Ananya
authors.initials: A
authors.lastname: Rakshit
authors.forename: Shubhi
authors.initials: S
authors.lastname: Jain
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Ankona
authors.initials: A
authors.lastname: Datta
mesh_terms: D002470:Cell Survival; D015195:Drug Design; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008345:Manganese / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D047028:Macrocyclic Compounds; D008345:Manganese