title: Motor neurone disease presenting with raised serum Troponin T.
abstract: Myocardial damage indicated by a rise in cardiac Troponin may not necessarily be due to a cardiac event. Many diseases such as sepsis, pulmonary embolism, heart and renal failure can also be associated with an elevated cardiac Troponin level. This brief report discusses the rare event of a patient with motor neurone disease, where the possible diagnosis of acute myocardial infarction arose due to an elevated cardiac Troponin. A 69-year-old gentleman presented with a history of a central chest ache of mild intensity, lasting a total of 2 h prior to complete resolution. Multiple cardiac Troponin assays were elevated, and echocardiography did not show any acute changes of myocardial damage. His electrocardiogram was also normal. This patient's raised cardiac Troponin was therefore explained on the basis of his active motor neurone disease. This rare case outlines the importance of considering motor neurone disease as a cause of elevated cardiac Troponin in the absence of clinical evidence of an acute coronary event.
authors.affiliation: Specialist Registrar in Rehabilitation Medicine, Neurorehabilitation Unit, Western Community Hospital, UK jonathan.mamo@nhs.net.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Mamo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D004562:Electrocardiography; D006801:Humans; D008297:Male; D016472:Motor Neuron Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D009203:Myocardial Infarction / Q000097:blood; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: Motor neurone disease; Troponin; myocardial infarction