title: Alectinib induces a durable (>15 months) complete response in an ALK-positive non-small cell lung cancer patient who progressed on crizotinib with diffuse leptomeningeal carcinomatosis.
authors.affiliation: Chao Family Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, California, USA.
authors.forename: Sai-Hong Ignatius
authors.initials: SH
authors.lastname: Ou
authors.affiliation: Chao Family Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, California, USA.
authors.forename: Karen R
authors.initials: KR
authors.lastname: Sommers
authors.affiliation: Chao Family Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, California, USA.
authors.forename: Michele C
authors.initials: MC
authors.lastname: Azada
authors.affiliation: Jonsson Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, USA.
authors.forename: Edward B
authors.initials: EB
authors.lastname: Garon
mesh_terms: D030301:Activin Receptors, Type II / Q000235:genetics; D000328:Adult; D002227:Carbazoles / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology; D000077547:Crizotinib; D005260:Female; D006801:Humans; D055756:Meningeal Carcinomatosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D010880:Piperidines / Q000008:administration & dosage*; D011720:Pyrazoles / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*; D011859:Radiography; D016032:Randomized Controlled Trials as Topic
chemical_list: D002227:Carbazoles; D010880:Piperidines; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II; C582670:alectinib