title: Left ventricular regional shape dynamics analysis by three-dimensional cardiac magnetic resonance imaging associated with left ventricular function in first-time myocardial infarction patients.
abstract: Geometric remodelling of the left ventricle (LV) following myocardial infarction reflects on the geometric characteristics directly. This study focuses on a potential index based on curvedness. Nine consecutive normal volunteers and thirty consecutive myocardial infarction patients underwent MRI scan (twenty-seven patients had follow-up scan). Short-axis cine images of all cases were delineated. Three dimensional LV models were reconstructed and restored for possible motion distortion. The curvedness values were computed over 16-segments nomenclature. The curvedness signal for each segment over twenty-two time frames were fitted using a second order Fourier Series. Fourier coefficients were extracted and unsupervised learning was conducted between normal and patient data. An accuracy of 89% and adjusted Rand Index of 0.5374 suggest that these Fourier Series and curvedness based features can be an useful index for prognosis and diagnosis in clinical practice.
authors.forename: Min
authors.initials: M
authors.lastname: Wan
authors.forename: Teo Soo
authors.initials: TS
authors.lastname: Kng
authors.forename: Xulei
authors.initials: X
authors.lastname: Yang
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Zhao
authors.forename: Wong Sum
authors.initials: WS
authors.lastname: Thai
authors.forename: Calvin Lim Chi
authors.initials: CL
authors.lastname: Wan
authors.forename: Liang
authors.initials: L
authors.lastname: Zhong
authors.forename: Ru San
authors.initials: RS
authors.lastname: Tan
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
mesh_terms: D005583:Fourier Analysis; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000503:physiopathology*; D016277:Ventricular Function, Left