title: Triglyceride accumulation inhibitory effects of new chromone glycosides from Drynaria fortunei.
abstract: Two new chromone glycosides, drynachromosides C (1) and D (2), along with five known chromones (3-7), were isolated from the rhizomes of Drynaria fortunei. The structures of the two new compounds were elucidated on the basis of physico-chemical property and spectroscopic data. Triglyceride (TG) accumulation inhibitory effects of the obtained chromones on 3T3-L1 cells were investigated. The results showed that 1, 2 and 5 exhibited inhibitory activity on TG accumulation. Effects of compounds 1 and 2 on mRNA expression of PPARγ, C/EBPα and aP2 in 3T3-L1 cells were also investigated.
authors.affiliation: a Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193 , P.R. China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Han
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Erwei
authors.initials: E
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Minghui
authors.initials: M
authors.lastname: Xia
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Xiumei
authors.initials: X
authors.lastname: Gao
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D051379:Mice; D015394:Molecular Structure; D047495:PPAR gamma / Q000378:metabolism; D029621:Polypodiaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D050656:Transcription Factor AP-2 / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*; D014312:Trisaccharides / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D002867:Chromones; D004187:Disaccharides; D006027:Glycosides; D047495:PPAR gamma; D050656:Transcription Factor AP-2; D014280:Triglycerides; D014312:Trisaccharides; C000602377:drynachromoside C; C000602378:drynachromoside D
keywords: Drynaria fortunei; chromone glycosides; inhibitory effects; triglyceride accumulation