title: Functional chromatographic technique for natural product isolation.
abstract: Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.
authors.affiliation: College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721-0207, USA. chapman@pharmacy.arizona.edu.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Lau
authors.forename: Damian J
authors.initials: DJ
authors.lastname: Mason
authors.forename: Nicole
authors.initials: N
authors.lastname: Eichhorst
authors.forename: Pearce
authors.initials: P
authors.lastname: Engelder
authors.forename: Celestina
authors.initials: C
authors.lastname: Mesa
authors.forename: E M
authors.initials: EM
authors.lastname: Kithsiri Wijeratne
authors.forename: G M Kamal B
authors.initials: GM
authors.lastname: Gunaherath
authors.forename: A A Leslie
authors.initials: AA
authors.lastname: Gunatilaka
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Eli
authors.initials: E
authors.lastname: Chapman
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification*; D002845:Chromatography
chemical_list: D001688:Biological Products