title: In vitro biodegradation behavior, mechanical properties, and cytotoxicity of biodegradable Zn-Mg alloy.
abstract: Zinc-Magnesium (Zn-Mg) alloy as a novel biodegradable metal holds great potential in biodegradable implant applications as it is more corrosion resistant than Magnesium (Mg). However, the mechanical properties, biodegradation uniformity, and cytotoxicity of Zn-Mg alloy remained as concerns. In this study, hot extrusion process was applied to Zn-1 wt % Mg (Zn-1Mg) to refine its microstructure. Effects of hot extrusion on biodegradation behavior and mechanical properties of Zn-1Mg were investigated in comparison with Mg rare earth element alloy WE43. Metallurgical analysis revealed significant grain size reduction, and immersion test found that corrosion rates of WE43 and Zn-1Mg were reduced by 35% and 57%, respectively after extrusion. Moreover, hot extrusion resulted in a much more uniform biodegradation in extruded Zn-1Mg alloy and WE43. In vitro cytotoxicity test results indicated that Zn-1Mg alloy was biocompatible. Therefore, hot extruded Zn-1Mg with homogenous microstructure, uniform as well as slow degradation, improved mechanical properties, and good biocompatibility was believed to be an excellent candidate material for load-bearing biodegradable implant application.
authors.affiliation: Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania, 19104.
authors.forename: Haibo
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Molecular Biology, Rowan University, Stratford, New Jersey, 08084.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Molecular Biology, Rowan University, Stratford, New Jersey, 08084.
authors.forename: Randy
authors.initials: R
authors.lastname: Strich
authors.affiliation: Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania, 19104.
authors.forename: Jack G
authors.initials: JG
authors.lastname: Zhou
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D015032:Zinc / Q000737:chemistry*
chemical_list: D000497:Alloys; D008274:Magnesium; D015032:Zinc
keywords: biodegradable metal; cytotoxicity; extrusion; mechanical properties; zinc alloy