title: Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus.
abstract: Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component. A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found. The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons.
authors.affiliation: Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia, povarovigor@mail.ru.
authors.forename: I S
authors.initials: IS
authors.lastname: Povarov
authors.forename: R V
authors.initials: RV
authors.lastname: Kondratenko
authors.forename: V I
authors.initials: VI
authors.lastname: Derevyagin
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitskii
mesh_terms: D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly