title: The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome.
abstract: OBJECTIVE
  Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress and complexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stress markers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  Sixty-seven consecutive patients with an early phase of ACS (<3 h) were included in this single-centre, cross-sectional, prospective study. Syntax and Gensini scores were calculated based on angiographic findings. Patients were divided into two CAD complexity groups according to their Syntax scores: low SYNTAX score (<22) and moderate to high SYNTAX score (>=22). Likewise patients were divided into two CAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score (<64) and intensive CAD with Gensini score >=64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidant capacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS /TAC.
  
  
  RESULTS
  There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly high in the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively).
  
  
  CONCLUSIONS
  Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACS patients.
authors.affiliation: Department of Cardiology, Ahi Evren Training and Research Hospital; Trabzon-Turkey. drtt61@gmail.com.
authors.forename: Turhan
authors.initials: T
authors.lastname: Turan
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Menteşe
authors.forename: Mustafa Tarık
authors.initials: MT
authors.lastname: Ağaç
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Akyüz
authors.forename: Selim
authors.initials: S
authors.lastname: Kul
authors.forename: Ahmet Çağrı
authors.initials: AÇ
authors.lastname: Aykan
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bektaş
authors.forename: Levent
authors.initials: L
authors.lastname: Korkmaz
authors.forename: Seda
authors.initials: S
authors.lastname: Öztaş Menteşe
authors.forename: İhsan
authors.initials: İ
authors.lastname: Dursun
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Çelik
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017023:Coronary Angiography; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D012720:Severity of Illness Index