title: New shell crosslinked micelles from dextran with hydrophobic end groups and their interaction with bioactive molecules.
abstract: Micelles formed in aqueous solution by dextran with hydrophobic (alkyl) end-groups were stabilized through divinyl sulfone crosslinking of the dextran shell. The efficacy of the crosslinking reaction was influenced by the divinyl sulfone amount, the pH and micelle concentration. Crosslinked micelles with a moderate crosslinking degree were further functionalized by attachment of 10 and 17 moles% N-(2-hydroxypropyl)-N,N-dimethyl-N-benzylammonium chloride groups along the dextran chain. The size and shape of both crosslinked micelles and their cationic derivatives were analyzed by DLS and TEM. The prepared micelles were able to bind anionic diclofenac (60-370 mg/g), hydrophobic anionic indometacin (70-120 mg/g), and hydrophobic alpha-tocopherol (170-220 mg/g) or ergocalciferol (90-110 mg/g) by hydrophobic or/and electrostatic forces. The release experiments and the antioxidant activity of bound alpha-tocopherol highlighted the potential of the new nano-sized micelles mainly as carriers for prolonged and controlled delivery of hydrophobic drugs.
authors.affiliation: "Petru Poni" Institute of Macrmolecular Chemistry, Natural Polymers, Aleea Gr. Ghica Voda 41A, 700487 Iasi, Romania. Electronic address: gmocanu@icmpp.ro.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Mocanu
authors.affiliation: "Petru Poni" Institute of Macrmolecular Chemistry, Natural Polymers, Aleea Gr. Ghica Voda 41A, 700487 Iasi, Romania.
authors.forename: Marieta
authors.initials: M
authors.lastname: Nichifor
authors.affiliation: "Petru Poni" Institute of Macrmolecular Chemistry, Natural Polymers, Aleea Gr. Ghica Voda 41A, 700487 Iasi, Romania.
authors.forename: Magdalena C
authors.initials: MC
authors.lastname: Stanciu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000494:pharmacology*; D002412:Cations; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry / Q000494:pharmacology; D004872:Ergocalciferols / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007213:Indomethacin / Q000737:chemistry / Q000494:pharmacology; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D013450:Sulfones / Q000737:chemistry; D024502:alpha-Tocopherol / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D002412:Cations; D003432:Cross-Linking Reagents; D003911:Dextrans; D004872:Ergocalciferols; D008823:Micelles; D013450:Sulfones; D004008:Diclofenac; C009873:divinyl sulfone; D024502:alpha-Tocopherol; D007213:Indomethacin
keywords: Crosslinking; Dextran; Divinyl sulfone; Drug delivery; Micelles; Polysaccharide