title: A space-time model for carbapenemase-producing Klebsiella pneumoniae (KPC) cluster quantification in a high-complexity hospital.
abstract: A retrospective space-time permutation model with non-Euclidean distance criteria was applied within a high-complexity hospital setting to quantitatively explore cluster patterns of 273 patients infected with or colonized by carbapenemase-producing Klebsiella pneumoniae during 4 years. Results were compared to standard nosocomial active-surveillance methods. Two clusters were identified in the period, suggesting that space-time strategies for cluster quantification within confined environments may be useful.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia,São Paulo,Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: Abboud
authors.affiliation: Associação Fundo de Incentivo a Pesquisa (AFIP),São Paulo,Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Monteiro
authors.affiliation: Instituto Dante Pazzanese de Cardiologia,São Paulo,Brazil.
authors.forename: J I D
authors.initials: JI
authors.lastname: França
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina,UNIFESP,São Paulo,Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Pignatari
authors.affiliation: Instituto Dante Pazzanese de Cardiologia,São Paulo,Brazil.
authors.forename: E E
authors.initials: EE
authors.lastname: De Souza
authors.affiliation: Instituto Nacional de Pesquisas Espaciais (INPE),São José dos Campos,São Paulo,Brazil.
authors.forename: E C G
authors.initials: EC
authors.lastname: Camargo
authors.affiliation: Instituto Nacional de Pesquisas Espaciais (INPE),São José dos Campos,São Paulo,Brazil.
authors.forename: A M V
authors.initials: AM
authors.lastname: Monteiro
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina,UNIFESP,São Paulo,Brazil.
authors.forename: R G
authors.initials: RG
authors.lastname: Dos Santos
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina,UNIFESP,São Paulo,Brazil.
authors.forename: C R V
authors.initials: CR
authors.lastname: Kiffer
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology; D016000:Cluster Analysis; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000175:diagnosis / Q000453:epidemiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D008826:Microbial Sensitivity Tests; D015233:Models, Statistical; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D062211:Spatio-Temporal Analysis; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: KPC; outbreaks; space–time; surveillance