title: Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment.
abstract: We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.
authors.affiliation: Microbiology & Infectious Diseases, SA Pathology and Flinders Medical Centre, Bedford Park, Australia.
authors.forename: Babak
authors.initials: B
authors.lastname: Rad
authors.affiliation: Division of Chemical Pathology, SA Pathology, Adelaide, Australia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saleem
authors.affiliation: Canterbury Health Laboratories, Christchurch, New Zealand.
authors.forename: Susan
authors.initials: S
authors.lastname: Grant
authors.affiliation: Canterbury Health Laboratories, Christchurch, New Zealand.
authors.forename: Christopher
authors.initials: C
authors.lastname: Florkowski
authors.affiliation: Canterbury Health Laboratories, Christchurch, New Zealand.
authors.forename: Penelope
authors.initials: P
authors.lastname: Coates
authors.affiliation: Microbiology & Infectious Diseases, SA Pathology and Flinders Medical Centre, Bedford Park, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Gordon
authors.affiliation: Division of Chemical Pathology, SA Pathology, Adelaide, Australia wayne.rankin@health.sa.gov.au.
authors.forename: Wayne
authors.initials: W
authors.lastname: Rankin
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D010522:Periostitis / Q000097:blood* / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome; D065819:Voriconazole / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole; D005459:Fluorides
keywords: L Drugs analytes; bone disorders; clinical studies