title: Genetically encoded tools: bridging the gap between neuronal identity and function.
abstract: Genetically encoded tools are positioned to serve a unique and critical role in bridging the gap between the genetic identity of neurons and their functional properties. However, the use of these tools is limited by our current understanding of cell-type identity. As we make technological advances that focus on capturing functional aspects of neurons such as connectivity, activity, and metabolic states, our understanding of neuronal identity will deepen and may enable the use of genetically encoded tools for modulating disease-specific circuits for therapeutic purposes.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Institute for Systems Genomics, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Yong Ku
authors.initials: YK
authors.lastname: Cho
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D005823:Genetics; D006801:Humans; D009474:Neurons / Q000737:chemistry* / Q000502:physiology*; D062308:Optogenetics
keywords: Neuronal identity; genetically encoded tools; optogenetics