title: [Relationship between hyperuricemia and primary nephrotic syndrome in children].
abstract: OBJECTIVE
  To analyze the relationship between hyperuricemia and primary nephrotic syndrome in childhood.
  
  
  METHODS
  A retrospective study was carried out in 107 children with primary nephrotic syndrome. The clinical data were analyzed with statistical methods to identify the related factors with hyperuricemia.
  
  
  RESULTS
  The morbidity of hyperuricemia in children with primary nephrotic syndrome was 45% (48/107). Compared to those in normal serum uric acid group, the incidence of hypertension (33%, 16/48), serum triglyceride [2.59(1.62-3.87) mmol/L], creatinine [43.85(33.38-56.38)mmol/L], urea [6.11(3.77-8.40)mmol/L] and blood uric acid/creatinine ratio [9.30(7.03-12.72)] increased while creatinine clearance rate [141.74(103.57-160.97)ml/(min·1.73 (2))] decreased in hyperuricemia group.
  
  
  CONCLUSIONS
  Hyperuricemia in children with primary nephrotic syndrome correlated with the increase of serum creatinine, urea and blood uric acid/creatinine ratio, the decrease of creatinine clearance rate and the occurance of hypertension.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Xiao
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Xuhui
authors.initials: X
authors.lastname: Zhong
mesh_terms: D002648:Child; D003404:Creatinine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D033461:Hyperuricemia / Q000453:epidemiology*; D009404:Nephrotic Syndrome / Q000453:epidemiology*; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid; D003404:Creatinine