title: SLX4: not SIMply a nuclease scaffold?
abstract: In this issue, Guervilly et al. (2015) and Ouyang et al. (2015) identify SUMO-interacting motifs (SIMs) in the SLX4 DNA repair nuclease scaffold protein that promote its functions in genome stability maintenance pathways independently of its ubiquitin-binding properties.
authors.affiliation: Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Ian
authors.initials: I
authors.lastname: Gibbs-Seymour
authors.affiliation: Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: niels.mailand@cpr.ku.dk.
authors.forename: Niels
authors.initials: N
authors.lastname: Mailand
mesh_terms: D000818:Animals; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism*; D016678:Genome; D006801:Humans; D021122:Protein Subunits / Q000378:metabolism*; D045522:Recombinases / Q000378:metabolism*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*; D000098843:Ubiquitin-Conjugating Enzyme UBC9
chemical_list: D004268:DNA-Binding Proteins; D021122:Protein Subunits; D045522:Recombinases; C117909:SUMO2 protein, human; C492189:SUMO3 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D014452:Ubiquitins; C095888:xeroderma pigmentosum group F protein; D044763:Ubiquitin-Conjugating Enzymes; D044767:Ubiquitin-Protein Ligases; C542319:SLX4 protein, human; D000098843:Ubiquitin-Conjugating Enzyme UBC9