title: Metastatic carcinoid tumor--atypical presentation.
abstract: Carcinoid tumor is a slow-growing type of neuroendocrine tumor, originating in the enterochromaffin cells and secreting mainly serotonin. Neuroendocrine tumors (NETs) are found throughout the intestinal tract, the appendix and terminal ileum being the most common locations, and are classified by site of origin and by degree of differentiation, with well-differentiated lesions representing those tumors formerly referred to as carcinoid tumors. The clinical symptoms are characterized by flushing, diarrhea, abdominal pain, and/or bronchial constriction and occur almost exclusively in patients with liver metastases due to the release of bioactive peptides and amines directly into the systemic circulation. We report the clinical, serological and histological diagnosis of a 67-years-old male patient with congestive heart failure secondary to carcinoid heart disease in the context of liver metastases of an ileum carcinoid tumor.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Medical Specialties (I).
authors.forename: Alina
authors.initials: A
authors.lastname: Pleşa
authors.forename: Emanuela
authors.initials: E
authors.lastname: Sarca
authors.forename: Roxana
authors.initials: R
authors.lastname: Maxim
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016084:Bronchoconstriction; D002276:Carcinoid Tumor / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D003967:Diarrhea / Q000209:etiology; D006333:Heart Failure / Q000209:etiology; D006338:Heart Neoplasms / Q000150:complications / Q000556:secondary / Q000601:surgery; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D009362:Neoplasm Metastasis; D017211:Treatment Failure; D016896:Treatment Outcome; D014463:Ultrasonography