title: Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy.
abstract: OBJECTIVE
  Despite the number of studies on neurometabolite changes in ADHD (Attention deficit/hyperactivity disorder), there is lack of evidence on neurometabolite associations with ADHD symptoms.
  
  
  BACKGROUND
  We aimed to find the correlations of neurometabolites with ADHD symptoms.
  
  
  METHODS
  Twenty ADHD children were examined by means of 1H-MRS. The spectra were taken from dorsolateral prefrontal cortex (DLPFC) and white matter behind DLPFC, bilaterally. Neurometabolites were correlated with ADHD-RS-IV (ADHD-Rating Scales IV), CPRS (Conners Parent rating Scale) and DPREMB (Daily Parent Rating of Evening and Morning Behavior) scores.
  
  
  RESULTS
  NAA/Cr (N-acetylaspartate/creatine) in the right DLPFC positively correlated with CPRS subscale IV learning problems and negatively correlated in the left white matter with DPREMB morning behavior subscale and ADHD-RS-IV score. Glx/Cr (glutamate + glutamine/creatine) positively correlated in the right white matter with ADHD-RS-IV and negatively correlated in the left white matter with DPREMB morning behavior subscale score. Cho/Cr (choline/creatine) in the left white matter negatively correlated with DPREMB morning behavior subscale and ADHD-RS-IV score.
  
  
  CONCLUSIONS
  ADHD symptoms could result from different activities of the left- and right-hemisphere prefrontal circuits. In consequence to impulses to novel task searching the increased right prefrontal circuit activity could be mediated by different motivational control (Fig. 9, Ref. 73).
authors.forename: V
authors.initials: V
authors.lastname: Husarova
authors.forename: M
authors.initials: M
authors.lastname: Bittsansky
authors.forename: I
authors.initials: I
authors.lastname: Ondrejka
authors.forename: D
authors.initials: D
authors.lastname: Dobrota
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001289:Attention Deficit Disorder with Hyperactivity / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D011859:Radiography; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism*
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline