title: Sensitivity of patients with familial cerebral cavernous malformations to therapeutic radiation.
abstract: Familial cerebral cavernous malformations are autosomal dominant conditions that can result in significant morbidity. A two-hit mechanism is accepted as likely responsible for formation of these malformations. We present two patients with this disease who received therapeutic radiation and developed very high numbers of malformations within the radiation ports, supporting radiation as an accelerator of lesion formation and suggesting implications for risks of radiation in this disease.
authors.affiliation: Department of Radiology, University of New Mexico, Albuquerque, New Mexico, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Golden
authors.forename: Saba
authors.initials: S
authors.lastname: Saeidi
authors.forename: Benny
authors.initials: B
authors.lastname: Liem
authors.forename: Eric
authors.initials: E
authors.lastname: Marchand
authors.forename: Leslie
authors.initials: L
authors.lastname: Morrison
authors.forename: Blaine
authors.initials: B
authors.lastname: Hart
mesh_terms: D001921:Brain / Q000473:pathology*; D005260:Female; D020786:Hemangioma, Cavernous, Central Nervous System / Q000209:etiology* / Q000235:genetics / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D016896:Treatment Outcome
keywords: magnetic resonance imaging; neuroradiology