title: An unusual presentation of ulcerative colitis.
abstract: Ulcerative colitis (UC) may have diverse extraintestinal manifestations. Nutritional deficiencies, medications or immune-mediated epiphenomena are considered to be pathogenic mechanisms involved. We describe a case of a 56-year-old woman who presented with rapidly progressive tingling paraesthesias in both lower limbs followed by sensory ataxia, ascending spastic quadriparesis, urgency and urge incontinence of 3 months duration. She had an episode of bloody diarrhoea 1 month later for which a colonoscopy was carried out with colonic biopsy features revealing a diagnosis of UC. In view of lack of alternative aetiology, the posterolateral column disease in our patient was attributed to an extraintestinal manifestation of UC. She improved dramatically with a course of intravenous steroids followed by tapering dose of oral steroids and oral mesalamine for her UC. Although rare, UC should be considered in the differential diagnosis of posterolateral column disease of the spinal cord in the appropriate clinical scenario.
authors.affiliation: Neurology, VSM Hospital, Mavelikkara, Kerala, India Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Kesav
authors.affiliation: Neurology, VSM Hospital, Mavelikkara, Kerala, India Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Khurana
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001259:Ataxia / Q000175:diagnosis / Q000209:etiology; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D003967:Diarrhea / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D020336:Paraparesis, Spastic / Q000175:diagnosis / Q000209:etiology; D010292:Paresthesia / Q000175:diagnosis / Q000209:etiology; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D053202:Urinary Incontinence, Urge / Q000175:diagnosis / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents