title: One-pot synthesis of water-soluble superparamagnetic iron oxide nanoparticles and their MRI contrast effects in the mouse brains.
abstract: Water-soluble superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition of iron (III) acetylacetonate (Fe(acac)3) in the mixture of poly(ethylene glycol) (PEG) and poly(ethylene imine) (PEI). The average sizes of the SPIONs are in the range of 6-12nm, which could be tuned by adjusting the synthesis temperature and molecular weight of PEI. Benefiting from the coating of hydrophilic PEG and PEI, the resulted SPIONs showed excellent colloidal stability in deionized water and other physiological buffers. The XRD patterns indicate that the obtained SPIONs are magnetite. The PEG/PEI-SPIONs exhibited high r2/r1 ratio. In vivo magnetic resonance imaging (MRI) of the mouse brains after intravenous injection of the SPIONs showed their good contrast effect. Considering the facile fabrication process and excellent imaging performance of the water soluble PEG-SPIONs and PEG/PEI-SPIONs, it is believed that the SPIONs will find great potential in advanced MRI.
authors.affiliation: State Key Laboratory Breeding Base of Nonferrous Metals and Specific Materials Processing, China; School of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004 Guangxi, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory Breeding Base of Nonferrous Metals and Specific Materials Processing, China; School of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004 Guangxi, China. Electronic address: baolinzhang@ymail.com.
authors.forename: Baolin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory Breeding Base of Nonferrous Metals and Specific Materials Processing, China; School of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004 Guangxi, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.affiliation: Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: gaofabao@yahoo.com.
authors.forename: Fabao
authors.initials: F
authors.lastname: Gao
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011859:Radiography; D012995:Solubility
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide
keywords: Magnetic resonance imaging; PEG; Superparamagnetic iron oxide nanoparticles; Thermal decomposition