title: [Survey of Hepatitis B infection and vaccination status among drug users in Xi'an].
abstract: OBJECTIVE
  To explore seroepidemiological status and vaccine coverage of hepatitis B among drug users in Xi'an.
  
  
  METHODS
  545 drug users in the Xi'an Compulsory Detoxification Center were asked to answer questionnaire and provide blood sample (3-5 ml) for test of HBsAg, anti-HBc and anti-HBs from March to June 2013. Totally, 545 subjects were surveyed and tested. All of them effectively completed the survey.
  
  
  RESULTS
  The positive rates of HBsAg, anti-HBc and anti-HBs were 29.4% (160/545), 60.0% (327/545) and 56.1% (306/545), respectively. Eighty five subjects (15.6%) were negative for all of the three markers. The prevalence of HBsAg and anti-HBc among injection drug users were 40.0% (94/235) and 65.6% (154/235), which was significantly higher than non- injection drug users' (21.6% (52/241), 58.5% (141/241)) and mixed non-injection and injection drug users ((20.3% (14/69), 46.4% (32/69)) (χ(2) = 23.518 and 9.017, respectively, P < 0.05) . The HBsAg positive rate (30.6% (153/500)) of subjects with more than once per day of drug using within one year was significantly higher than those who used drugs for 2-3 times per week (15.6% (7/45)) (χ(2) = 4.51, P < 0.05). Only 11.7% (64/545) of drug users had a clear history of hepatitis B vaccination. The vaccination rate of subjects (3.5% (5/141)) with primary education or below was significantly lower than those with high school (16.3% (45/276)) (χ(2) = 26.61, P < 0.05). The vaccination rate of subjects (7.8% (12/153)) over 45 years old was significantly lower than that of subjects below 30 years old (15.9% (21/132)) and 30-44 years old (11.9% (31/260)) (χ(2) = 30.36, P < 0.05). The vaccinees had a significantly higher positive rate of anti-HBs (73.4% (47/64)) than those who without vaccination (53.8% (259/481)) (χ(2) = 8.81, P = 0.003), but the positive rates of HBsAg (16.7% (11/64)) were lower than those who without vaccination (31.0% (149/481)) (χ(2) = 23.52 and 9.02, respectively;P > 0.05).
  
  
  CONCLUSIONS
  The HBV infection status among drug users in Xi'an was in serious condition, while a low vaccination rate was also discovered among them.
authors.affiliation: Public Health School, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Zu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wei
authors.forename: Lijuan
authors.initials: L
authors.lastname: You
authors.forename: Lingling
authors.initials: L
authors.lastname: Kou
authors.forename: Hengxin
authors.initials: H
authors.lastname: Li
authors.affiliation: Email: zhuanggh@mail.xjtu.edu.cn.
authors.forename: Guihua
authors.initials: G
authors.lastname: Zhuang
mesh_terms: D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D055030:Drug Users; D006509:Hepatitis B / Q000453:epidemiology*; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D014611:Vaccination
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines