title: Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational study.
abstract: BACKGROUND
  Obesity, type 2 diabetes and atrial fibrillation (AF) are closely associated, but the underlying mechanisms are not fully understood. We aimed to explore associations between body mass index (BMI) or weight change with risk of AF in patients with type 2 diabetes.
  
  
  METHODS
  A total of 7,169 participations with newly diagnosed type 2 diabetes were stratified according to baseline BMI, and after a second BMI measurement within 18 months, further grouped according to relative weight change as "weight gain" (>1 BMI unit), "stable weight" (+/- 1 BMI unit) and "weight loss" (<1 BMI unit). The mean follow-up period was 4.6 years, and the risk of AF was estimated using adjusted Cox regression models.
  
  
  RESULTS
  Average age at diabetes diagnosis was 60 years and the patients were slightly obese (mean BMI 30.2 kg/m(2)). During follow-up, 287 patients developed incident AF, and those with overweight or obesity at baseline had 1.9-fold and 2.9-fold higher risk of AF, respectively, than those with normal BMI. The 14% of the patients with subsequent weight gain had 1.5-fold risk of AF compared with those with stable weight or weight loss.
  
  
  CONCLUSIONS
  In patients with newly diagnosed type 2 diabetes, baseline overweight and obesity, as well as modest weight increase during the first 18 months after diagnosis, were associated with a substantially increased risk of incident AF. Patients with type 2 diabetes may benefit from efforts to prevent weight gain in order to reduce the risk of incident AF.
  
  
  BACKGROUND
  ClinicalTrials.gov: NCT01121315.
authors.affiliation: Department of Cardiology, Oslo University Hospital, Ullevaal, PB 4956, Nydalen, 0424, Oslo, Norway. uxirgr@ous-hf.no.
authors.forename: Irene
authors.initials: I
authors.lastname: Grundvold
authors.affiliation: AstraZeneca Nordic, Södertälje, Sweden. Johan.Bodegard@astrazeneca.com.
authors.forename: Johan
authors.initials: J
authors.lastname: Bodegard
authors.affiliation: Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden. peter.nilsson@med.lu.se.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Nilsson
authors.affiliation: Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. bodil.svennblad@ucr.uu.se.
authors.forename: Bodil
authors.initials: B
authors.lastname: Svennblad
authors.affiliation: Department of Public health and Caring Science, Uppsala University, Uppsala, Sweden. gunnar.johansson@pubcare.uu.se.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Johansson
authors.affiliation: Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. carl.johan.ostgren@liu.se.
authors.forename: Carl Johan
authors.initials: CJ
authors.lastname: Östgren
authors.affiliation: Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. johan.sundstrom@medsci.uu.se.|Department of Medical Sciences, Uppsala University, Uppsala, Sweden. johan.sundstrom@medsci.uu.se.
authors.forename: Johan
authors.initials: J
authors.lastname: Sundström
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000453:epidemiology; D015992:Body Mass Index; D001835:Body Weight; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology; D005500:Follow-Up Studies; D012189:Retrospective Studies; D012307:Risk Factors