title: Effect of different cross-linking methods and processing parameters on drug release from hydrogel beads.
abstract: The purpose of this work was to evaluate different methods of cross-linking for developing diltiazem-resin complex loaded carboxymethyl xanthan gum (CMXG) hydrogel beads to achieve highest possible drug entrapment and extended release for effective cardio-protection. The hydrogel beads were prepared by ionic cross-linking and dual cross-linking using simultaneous (SIM) and sequential (SEQ) methods. Among the three methods, SEQ method produced smaller sized beads having higher drug entrapment efficacy and prolonged release characteristics as evidenced from mean dissolution time and diffusion coefficient of drug. Keeping the concentration of ionic cross-linker constant, increase in the amount of covalent cross-linker and cross-linking time decreased the drug release. Higher release of the drug in acid solution was attributed to the higher solubility of the basic drug and higher swelling of the matrices in acid solution. Comparison of FTIR spectra, drug content and dissolution profiles indicated that the drug was stable in the beads when kept under stress condition up to 3 months. In conclusion, the sequential method was found superior for producing CMXG hydrogel beads as a prolonged release delivery device in cardiovascular diseases.
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C. Mallik Road, Jadavpur, Kolkata 700032, West Bengal, India.
authors.forename: Shataneek
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C. Mallik Road, Jadavpur, Kolkata 700032, West Bengal, India.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Maity
authors.affiliation: Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, 188, Raja S.C. Mallik Road, Jadavpur, Kolkata 700032, West Bengal, India. Electronic address: biswanathsa2003@yahoo.com.
authors.forename: Biswanath
authors.initials: B
authors.lastname: Sa
mesh_terms: D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000737:chemistry; D003188:Composite Resins / Q000737:chemistry; D004058:Diffusion; D004110:Diltiazem / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010316:Particle Size
chemical_list: D002317:Cardiovascular Agents; D003188:Composite Resins; D004337:Drug Carriers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004110:Diltiazem
keywords: Diltiazem; Drug release; Method of cross-linking; Resinate; Swelling