title: ADHD, autism and neuroradiological complications among phenylketonuric children in Upper Egypt.
abstract: The aim of this study is to evaluate the neuropsychological status in a cohort of children with early and continuously treated phenylketonuria in Assiut, Upper Egypt. The study was implemented in seventy-eight phenylketonuria (PKU) children. Only 34 patients met the inclusion criteria. Investigated patients were evaluated according to detailed history, neurological examination, Childhood Autism Rating Scale, full scale Intelligence Quotient, attention deficit hyperactivity disorder, electroencephalography and magnetic resonance imaging (MRI). This study concluded that the prognosis for early diagnosed children with PKU treated from the first weeks of life is generally good. However, they are at increased risk for neurological complications and behavioral problems. So, neonatal screening for PKU is highly recommended in Egypt, for early detection and management. In addition, neuropsychological and MRI assessments in PKU children should be done.
authors.affiliation: Department of Pediatrics, Assiut University, Asyût, 71516, Egypt. ksaad8@yahoo.com.
authors.forename: Khaled
authors.initials: K
authors.lastname: Saad
authors.affiliation: Department of Neuropsychiatry, Assiut University, Asyût, 71516, Egypt.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Elserogy
authors.affiliation: Department of Neuropsychiatry, Assiut University, Asyût, 71516, Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Abdel Rahman
authors.affiliation: Department of Psychiatry, College of Medicine, Almajmaah University, Al Majma'ah, KSA.
authors.forename: Abdulrahman Abdullah
authors.initials: AA
authors.lastname: Al-Atram
authors.affiliation: Department of Pediatrics, Assiut University, Asyût, 71516, Egypt.
authors.forename: Ismail L
authors.initials: IL
authors.lastname: Mohamad
authors.affiliation: Department of Clinical Pathology, Assiut University, Asyût, 71516, Egypt.
authors.forename: Tarek T H
authors.initials: TT
authors.lastname: ElMelegy
authors.affiliation: Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
authors.forename: Geir
authors.initials: G
authors.lastname: Bjørklund
authors.affiliation: Department of Community Health Nursing, Assiut University, Asyût, 71516, Egypt.
authors.forename: Amira A
authors.initials: AA
authors.lastname: El-Houfy
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology*; D001321:Autistic Disorder / Q000453:epidemiology*; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010661:Phenylketonurias / Q000175:diagnosis / Q000178:diet therapy / Q000453:epidemiology*
keywords: ADHD; Autism; Children; Phenylketonuria