title: The first 2(IB),3(IA)-heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes.
abstract: Novel 2,3-heterodisubstituted β-cyclodextrin derivatives were designed as artificial enzymes to degrade chemical warfare agents. One of them reduced the acetylcholinesterase inhibitory potential by soman faster than its monosubstituted analog.
authors.affiliation: Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France. francois.estour@univ-rouen.fr.
authors.forename: S
authors.initials: S
authors.lastname: Letort
authors.forename: D
authors.initials: D
authors.lastname: Mathiron
authors.forename: T
authors.initials: T
authors.lastname: Grel
authors.forename: C
authors.initials: C
authors.lastname: Albaret
authors.forename: S
authors.initials: S
authors.lastname: Daulon
authors.forename: F
authors.initials: F
authors.lastname: Djedaïni-Pilard
authors.forename: G
authors.initials: G
authors.lastname: Gouhier
authors.forename: F
authors.initials: F
authors.lastname: Estour
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002619:Chemical Warfare Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D015394:Molecular Structure; D012999:Soman / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D047392:beta-Cyclodextrins; D012999:Soman; D000110:Acetylcholinesterase; C031215:betadex