title: Treatment of Clostridium difficile infections.
abstract: Vancomycin and metronidazole were historically considered equivalent therapies for the management of Clostridium difficile infections (CDI); however, recent data confirm more favorable outcomes with vancomycin. Fidaxomicin is a narrow spectrum antibiotic that has an advantage in reducing recurrence rates compared with vancomycin, possibly owing to its sparing effect on normal colonic microbiota. Data are limited for guiding management of CDI recurrences, particularly multiple recurrences. Several empiric approaches to manage these cases are reviewed.
authors.affiliation: Department of Pharmacy, Presence Resurrection Medical Center, 7435 West Talcott Avenue, Chicago, IL 60631, USA.
authors.forename: Melinda M
authors.initials: MM
authors.lastname: Soriano
authors.affiliation: Research Service, Hines VA Hospital, 5000 South 5th Street, Hines, IL 60141, USA. Electronic address: stuart.johnson2@va.gov.
authors.forename: Stuart
authors.initials: S
authors.lastname: Johnson
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000188:drug therapy / Q000382:microbiology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D000077732:Fidaxomicin; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D009574:Nitro Compounds; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012294:Rifamycins / Q000627:therapeutic use; D000078262:Rifaximin; D013844:Thiazoles / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009574:Nitro Compounds; D012294:Rifamycins; D013844:Thiazoles; D008795:Metronidazole; D014640:Vancomycin; D000078262:Rifaximin; C041747:nitazoxanide; D000077732:Fidaxomicin
keywords: Antibiotic; Clostridium difficile; Treatment