title: Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform.
abstract: A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO2 NPs} nanoplatform selectively targeted folate-receptor over-expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells.
authors.affiliation: Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
authors.forename: Hui-Jing
authors.initials: HJ
authors.lastname: Xiang
authors.forename: Lu
authors.initials: L
authors.lastname: An
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tang
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Jin-Gang
authors.initials: JG
authors.lastname: Liu
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D009603:Nitroso Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D009603:Nitroso Compounds; D009942:Organometallic Compounds; D026082:Singlet Oxygen; D009569:Nitric Oxide; D012428:Ruthenium