title: Shenfu injection for intradialytic hypotension: a systematic review and meta-analysis.
abstract: Objective. To evaluate the effectiveness and safety of Shenfu injection (SFI) for intradialytic hypotension (IDH). Methods. A systematic review of data sources published as of April 2014 was conducted. These included the Cochrane Central Register of Controlled Trials (2014 issue 4), Pubmed, Embase, CBM, CNKI, VIP, and Wangfang Data. Randomized controlled trials (RCTs) involving SFI for treatment and prevention of IDH were identified. Two researchers independently selected articles, extracted data, assessed quality, and cross checked the results. Revman 5.2 was used to analyze the results. Results. Eight RCTs were included. The meta-analysis indicated that compared with conventional therapies alone, SFI could elevate systolic blood pressure (SBP), increase the clinical effective rate, decrease the incidence of hypotension, increase serum albumin (ALB) levels, and reduce C-reactive protein (CRP) levels without serious adverse effects. GRADE Quality of Evidence. the quality of SBP, the effective rate, ALB, and CRP were low, and hypotension incidence and DBP were very low. Conclusions. SFI is more effective than conventional therapies for prevention and treatment of IDH. However, a clinical recommendation is not warranted due to the small number of studies included and low methodology quality. Multi-center and high-quality RCTs with large sample sizes are needed to provide stronger evidence.
authors.affiliation: The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Yenan
authors.identifier: 0000-0002-4926-2904
authors.initials: Y
authors.lastname: Mo
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Xindong
authors.initials: X
authors.lastname: Qin
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Zhiren
authors.initials: Z
authors.lastname: He
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Lin
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Qinqing
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Youqing
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Emergency Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Zhuangzhu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Nephropathy Department, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang