title: Drug eruptions induced by allopurinol associated with HLA-B*5801.
abstract: Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA-BFNx015801 allele is a very strong marker for allopurinol-induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-BFNx015801 allele and review the literature on the association between HLA-BFNx015801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search.
authors.forename: Meihua
authors.initials: M
authors.lastname: Zeng
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Wenliang
authors.initials: W
authors.lastname: Yan
authors.forename: Qingtao
authors.initials: Q
authors.lastname: Kong
authors.affiliation: Department of Dermatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China 210002, .
authors.forename: Hong
authors.initials: H
authors.lastname: Sang
mesh_terms: D000368:Aged; D000483:Alleles; D000493:Allopurinol / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000235:genetics; D006074:Gout Suppressants / Q000009:adverse effects*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006074:Gout Suppressants; D015235:HLA-B Antigens; C500126:HLA-B*58:01 antigen; D000493:Allopurinol