title: Histone Demethylases in Colon Cancer.
abstract: Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer. Colon cancer is the third most common malignancy worldwide and the second leading cause of cancer deaths in the United States. The key protein families responsible for demethylation of histones, histone demethylases, have emerged as new therapeutic targets in different cancer types including colon cancer. These families are of great interest as potential novel biomarkers for diagnosis and targets for therapy and prevention of colon cancer. In this manuscript, we will discuss our current understanding of the histone demethylase family, and the role they play as epigenetic activators or repressors of different genes in colon cancer.
authors.affiliation: Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Santanu
authors.initials: S
authors.lastname: Paul
authors.affiliation: Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Satish
authors.initials: S
authors.lastname: Ramalingam
authors.affiliation: Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Dharmalingam
authors.initials: D
authors.lastname: Subramaniam
authors.affiliation: Hematology & Oncology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Joaquina
authors.initials: J
authors.lastname: Baranda
authors.affiliation: Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas ; Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Anant
authors.affiliation: Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas ; Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Animesh
authors.initials: A
authors.lastname: Dhar
keywords: Colon Cancer; Epigenetic; Histone Lysine Demethylases; JMJD; KDM; LSD