title: Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies.
abstract: Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Susana
authors.initials: S
authors.lastname: Brun
authors.affiliation: Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université de Strasbourg, CNRS, France.
authors.forename: Wissam
authors.initials: W
authors.lastname: Beaino
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kremer
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Omar
authors.initials: O
authors.lastname: Taleb
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Ayikoe Guy
authors.initials: AG
authors.lastname: Mensah-Nyagan
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Chanh D
authors.initials: CD
authors.lastname: Lam
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Greer
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: de Seze
authors.affiliation: Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, France. Electronic address: trif@unistra.fr.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Trifilieff
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004594:Electrophysiology; D005071:Evoked Potentials / Q000502:physiology; D020381:Interleukin-17 / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D018993:Myelin P0 Protein / Q000737:chemistry* / Q000633:toxicity*; D010455:Peptides / Q000633:toxicity; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000473:pathology / Q000503:physiopathology; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D020381:Interleukin-17; D018993:Myelin P0 Protein; D010455:Peptides
keywords: Animal model; CIDP; Chronic EAN; Electrophysiology; Immunology; Sciatic nerve immunohistochemistry; Thiopalmitoylated P0 peptide