title: A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging.
abstract: We report a two-photon fluorescent probe for ratiometric imaging of cysteamine in situ. This probe can detect the levels of endogenous cysteamine with statistical significance in live cells and brain hippocampal tissues, revealing that cysteamine is localized mainly in the perikaria of the pyramidal neurons and the granule cells.
authors.affiliation: Department of Chemistry and Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea. kimhm@ajou.ac.kr.
authors.forename: Avik R
authors.initials: AR
authors.lastname: Sarkar
authors.forename: Cheol Ho
authors.initials: CH
authors.lastname: Heo
authors.forename: Eunjin
authors.initials: E
authors.lastname: Kim
authors.forename: Hyo Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Hardev
authors.initials: H
authors.lastname: Singh
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Hyuk
authors.initials: H
authors.lastname: Kang
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Hwan Myung
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003543:Cysteamine / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008856:Microscopy, Fluorescence; D017785:Photons; D051381:Rats
chemical_list: D005456:Fluorescent Dyes; D003543:Cysteamine