title: Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters.
abstract: Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.
authors.affiliation: Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan, Republic of China.
authors.forename: You-Liang
authors.initials: YL
authors.lastname: Hsieh
authors.forename: Peiying
authors.initials: P
authors.lastname: Pai
authors.forename: Tsung-Jung
authors.initials: TJ
authors.lastname: Ho
authors.forename: Li-Chin
authors.initials: LC
authors.lastname: Chung
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Cheng
authors.forename: Chieh-Hsi
authors.initials: CH
authors.lastname: Wu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Fan
authors.forename: Cecilia Hsuan
authors.initials: CH
authors.lastname: Day
authors.forename: Chia-Yao
authors.initials: CY
authors.lastname: Shen
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D006224:Cricetinae; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D015850:Interleukin-6 / Q000502:physiology*; D008297:Male; D008647:Mesocricetus; D050796:STAT3 Transcription Factor / Q000378:metabolism; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D002791:Cholesterol, Dietary; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; D013440:Sulfides; C038491:allyl sulfide; D048049:Extracellular Signal-Regulated MAP Kinases