title: Alcohol cross-coupling for the kinetic resolution of diols via oxidative esterification.
abstract: We present an organocatalytic C-O-bond cross-coupling strategy to kinetically resolve racemic diols with aromatic and aliphatic alcohols, yielding enantioenriched esters. This one-pot protocol utilizes an oligopeptide multicatalyst, m-CPBA as the oxidant, and N,N'-diisopropylcarbodiimide as the activating agent. Racemic acyclic diols as well as trans-cycloalkane-1,2-diols were kinetically resolved, achieving high selectivities and good yields for the products and recovered diols.
authors.affiliation: Institute of Organic Chemistry, Justus-Liebig University , Heinrich-Buff-Ring 58, 35392 Giessen, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Hofmann
authors.forename: Jan M
authors.initials: JM
authors.lastname: Schümann
authors.forename: Peter R
authors.initials: PR
authors.lastname: Schreiner