title: Selection of biologics for patients with metastatic colorectal cancer: the role of predictive markers.
abstract: With the advent of biologics, the survival and quality of life of patients diagnosed with metastatic colorectal cancer (mCRC) has improved. These agents include anti-VEGF agents (bevacizumab/aflibercept), anti-EGFR antibodies (panitumumab/cetuximab) and regorafenib (an oral multi-kinase inhibitor). With the use of the novel therapeutics, there was a notable increase in the median survival of patients with mCRC; however, there are still several unmet needs with the use of novel therapeutics in mCRC. The focus of this editorial is to highlight some of these issues alongside results of some of the important clinical trials and other studies presented at the American Society of Clinical Oncology meeting last year.
authors.affiliation: Division of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, USA.
authors.forename: Pashtoon Murtaza
authors.initials: PM
authors.lastname: Kasi
authors.forename: Joleen M
authors.initials: JM
authors.lastname: Hubbard
authors.forename: Axel
authors.initials: A
authors.lastname: Grothey
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000008:administration & dosage; D001685:Biological Factors / Q000627:therapeutic use*; D015415:Biomarkers; D000068818:Cetuximab / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D009362:Neoplasm Metastasis; D000077544:Panitumumab; D010671:Phenylurea Compounds / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D040262:Receptors, Vascular Endothelial Growth Factor / Q000008:administration & dosage; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage; D018631:ras Proteins / Q000235:genetics*
chemical_list: D000911:Antibodies, Monoclonal; D001685:Biological Factors; D015415:Biomarkers; D010671:Phenylurea Compounds; D011725:Pyridines; D011993:Recombinant Fusion Proteins; C533178:aflibercept; C559147:regorafenib; D000068258:Bevacizumab; D000077544:Panitumumab; D040262:Receptors, Vascular Endothelial Growth Factor; D018631:ras Proteins; D000068818:Cetuximab
keywords: EGFR; RAS; VEGF; aflibercept; bevacizumab; biologics; cetuximab; metastatic colorectal cancer; panitumumab; regorafenib