title: The gold(i)-catalysed protodecarboxylation mechanism.
abstract: A mechanistic study of the gold-catalysed protodecarboxylation is described. Each reaction step has been investigated experimentally and computationally. More specifically, the activation parameters for the decarboxylation step have been determined through kinetic studies. Further experimental studies on the hydrolysis of the arylgold intermediate have revealed that the protodeauration can become competitive with the decarboxylation process at high conversions. This switch in rate-limiting step has been shown to be pKa -dependent. These studies have been supported by DFT calculations and permit a better understanding of which prevalent features of the reaction mechanism account for the decarboxylation process.
authors.affiliation: EastCHEM, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife, KY16 9ST (UK).
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dupuy
authors.forename: Luke
authors.initials: L
authors.lastname: Crawford
authors.forename: Michael
authors.initials: M
authors.lastname: Bühl
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan
keywords: N-heterocyclic carbenes; decarboxylation; gold; mechanism; protodeauration