title: Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
abstract: A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i.
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad 500 007, India. Electronic address: ashokdou@gmail.com.
authors.forename: Ashok
authors.initials: A
authors.lastname: Dongamanti
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad 500 007, India.
authors.forename: Vikas Kumar
authors.initials: VK
authors.lastname: Aamate
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad 500 007, India.
authors.forename: Mohan Gandhi
authors.initials: MG
authors.lastname: Devulapally
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad 500 007, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Gundu
authors.affiliation: Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India.
authors.forename: Meena Kumari
authors.initials: MK
authors.lastname: Kotni
authors.affiliation: Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India.
authors.forename: Vijjulatha
authors.initials: V
authors.lastname: Manga
authors.affiliation: Laboratory of X-ray, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Balasubramanian
authors.affiliation: Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Prasad
authors.initials: P
authors.lastname: Ernala
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D062105:Molecular Docking Simulation; D010100:Oxygen / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D005419:Flavonoids; D006571:Heterocyclic Compounds; D010100:Oxygen
keywords: Antimicrobial activity; Flavonoid framework; Medium sized rings; Molecular docking