title: Design and construction of polymerized-chitosan coated Fe3O4 magnetic nanoparticles and its application for hydrophobic drug delivery.
abstract: In this study, a novel hydrogel, chitosan (CS) crosslinked carboxymethyl-β-cyclodextrin (CM-β-CD) polymer modified Fe3O4 magnetic nanoparticles was synthesized for delivering hydrophobic anticancer drug 5-fluorouracil (CS-CDpoly-MNPs). Carboxymethyl-β-cyclodextrin being grafted on the Fe3O4 nanoparticles (CDpoly-MNPs) contributed to an enhancement of adsorption capacities because of the inclusion abilities of its hydrophobic cavity with insoluble anticancer drugs through host-guest interactions. Experimental results indicated that the amounts of crosslinking agent and bonding times played a crucial role in determining morphology features of the hybrid nanocarriers. The nanocarriers exhibited a high loading efficiency (44.7±1.8%) with a high saturation magnetization of 43.8emu/g. UV-Vis spectroscopy results showed that anticancer drug 5-fluorouracil (5-Fu) could be successfully included into the cavities of the covalently linked CDpoly-MNPs. Moreover, the free carboxymethyl groups could enhance the bonding interactions between the covalently linked CDpoly-MNPs and anticancer drugs. In vitro release studies revealed that the release behaviors of CS-CDpoly-MNPs carriers were pH dependent and demonstrated a swelling and diffusion controlled release. A lower pH value led to swelling effect and electrostatic repulsion contributing to the protonation amine impact of NH3(+), and thus resulted in a higher release rate of 5-Fu. The mechanism of 5-Fu encapsulated into the magnetic chitosan nanoparticles was tentatively proposed.
authors.affiliation: Key Laboratory for Liquid-solid Structural Evolution and Processing of Materials (Ministry of Education), Engineering Ceramics Key Laboratory of Shandong Province, Shandong University, Jinan 250061, PR China; School of Materials Science and Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: Yongling
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Materials Science & Engineering, CSIRO, Highett Vic 3190, Australia.
authors.forename: Shirley Z
authors.initials: SZ
authors.lastname: Shen
authors.affiliation: College of Chemical Engineering, China University of Petroleum, Qing Dao 266555, PR China.
authors.forename: Huadong
authors.initials: H
authors.lastname: Sun
authors.affiliation: Key Laboratory for Liquid-solid Structural Evolution and Processing of Materials (Ministry of Education), Engineering Ceramics Key Laboratory of Shandong Province, Shandong University, Jinan 250061, PR China; School of Materials Science and Engineering, University of Jinan, Jinan 250022, PR China. Electronic address: sunkangning@sdu.edu.cn.
authors.forename: Kangning
authors.initials: K
authors.lastname: Sun
authors.affiliation: Key Laboratory for Liquid-solid Structural Evolution and Processing of Materials (Ministry of Education), Engineering Ceramics Key Laboratory of Shandong Province, Shandong University, Jinan 250061, PR China; School of Materials Science and Engineering, University of Jinan, Jinan 250022, PR China. Electronic address: mse_liuft@ujn.edu.cn.
authors.forename: Futian
authors.initials: F
authors.lastname: Liu
authors.affiliation: School of Materials Science and Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Qi
authors.affiliation: School of Materials Science and Engineering, University of Jinan, Jinan 250022, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D058185:Magnetite Nanoparticles / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D020099:Coated Materials, Biocompatible; D058185:Magnetite Nanoparticles; D048271:Chitosan; D005472:Fluorouracil
keywords: 5-Fluorouracil; Carboxymethyl-β-cyclodextrin; Chitosan; Drug delivery; Fe(3)O(4) magnetic nanoparticles