title: Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography.
abstract: The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.
authors.affiliation: Technische Universität Dresden, Faculty of Medicine CGC, Department of Anesthesiology and Intensive Care Medicine and Clinical Sensoring and Monitoring, Germany ; Authors contributed equally to this paper.
authors.forename: Christian
authors.initials: C
authors.lastname: Schnabel
authors.affiliation: Technische Universität Dresden, Faculty of Medicine CGC, Clinic for Cardiac Surgery, Germany ; Authors contributed equally to this paper.
authors.forename: Anett
authors.initials: A
authors.lastname: Jannasch
authors.affiliation: Technische Universität Dresden, Faculty of Medicine CGC, Department of Anesthesiology and Intensive Care Medicine and Clinical Sensoring and Monitoring, Germany ; Technische Universität Dresden, Faculty of Medicine CGC, Clinic for Cardiac Surgery, Germany ; Authors contributed equally to this paper.
authors.forename: Saskia
authors.initials: S
authors.lastname: Faak
authors.affiliation: Technische Universität Dresden, Faculty of Medicine CGC, Clinic for Cardiac Surgery, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Waldow
authors.affiliation: Technische Universität Dresden, Faculty of Medicine CGC, Department of Anesthesiology and Intensive Care Medicine and Clinical Sensoring and Monitoring, Germany.
authors.forename: Edmund
authors.initials: E
authors.lastname: Koch
keywords: (000.1430) Biology and medicine; (170.2655) Functional monitoring and imaging; (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.6935) Tissue characterization