title: Clinical outcomes in elderly patients with advanced non-small cell lung cancer: results from ARIES, a bevacizumab observational cohort study.
abstract: OBJECTIVE
  Retrospective analyses from first-line clinical studies in advanced non-small cell lung cancer (NSCLC) have reported conflicting results on progression-free survival (PFS) and overall survival benefits with the addition of bevacizumab to chemotherapy in elderly patients. Here we report effectiveness and safety outcomes by age subgroup for patients with NSCLC in the ARIES observational cohort study.
  
  
  METHODS
  ARIES enrolled patients with advanced non-squamous NSCLC who received first-line bevacizumab-containing treatment per physician's choice. Kaplan-Meier estimates were used to calculate medians and 95% confidence intervals for PFS and overall survival for patients aged <65, ≥65, <75 and ≥75 years.
  
  
  RESULTS
  In total, 1967 patients receiving first-line treatment with bevacizumab and chemotherapy were enrolled. The median PFS and overall survival values were 6.4 (95% confidence interval = 6.0-6.8) and 14.2 (95% confidence interval = 12.7-15.2) months for patients aged <65 years, respectively, and 6.8 (95% confidence interval = 6.3-7.0) and 12.1 (95% confidence interval = 11.4-13.1) months for patients ≥65 years, respectively. For patients <75 years, the median PFS and overall survival values were 6.6 (95% confidence interval = 6.3-6.9) and 13.5 (95% confidence interval = 12.6-14.5) months, respectively, and 6.6 (95% confidence interval = 5.9-7.1) and 11.6 (95% confidence interval = 10.0-12.5) months, respectively, for patients ≥75 years. Incidence proportions of bevacizumab-associated adverse events were generally similar across all age groups.
  
  
  CONCLUSIONS
  Data from the ARIES study suggest that treatment with bevacizumab in combination with chemotherapy is a viable first-line treatment option for elderly bevacizumab-eligible patients with advanced non-squamous NSCLC.
authors.affiliation: Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA. Electronic address: wozniakt@karmanos.org.
authors.forename: A J
authors.initials: AJ
authors.lastname: Wozniak
authors.affiliation: Scripps Clinic, La Jolla, CA, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Kosty
authors.affiliation: UM Sylvester Comprehensive Cancer Center, Miami, FL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jahanzeb
authors.affiliation: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Brahmer
authors.affiliation: Sarah Cannon Research Institute, Nashville, TN, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Spigel
authors.affiliation: Genentech, Inc., South San Francisco, CA, USA.
authors.forename: L
authors.initials: L
authors.lastname: Leon
authors.affiliation: Genentech, Inc., South San Francisco, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Fish
authors.affiliation: Genentech, Inc., South San Francisco, CA, USA.
authors.forename: E D
authors.initials: ED
authors.lastname: Flick
authors.affiliation: Genentech, Inc., South San Francisco, CA, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Hazard
authors.affiliation: Yale Cancer Center and Smilow Cancer Hospital, New Haven, CT, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Lynch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000068258:Bevacizumab / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D008175:Lung Neoplasms / Q000188:drug therapy; D011446:Prospective Studies; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000068258:Bevacizumab
keywords: Bevacizumab; NSCLC; chemotherapy; elderly; observational cohort study