title: Toxin effect on protein biosynthesis in eukaryotic cells: a simple kinetic model.
abstract: A model for toxin inhibition of protein synthesis inside eukaryotic cells is presented. Mitigation of this effect by introduction of an antibody is also studied. Antibody and toxin (ricin) initially are delivered outside the cell. The model describes toxin internalization from the extracellular into the intracellular domain, its transport to the endoplasmic reticulum (ER) and the cleavage inside the ER into the RTA and RTB chains, the release of RTA into the cytosol, inactivation (depurination) of ribosomes, and the effect on translation. The model consists of a set of ODEs which are solved numerically. Numerical results are illustrated by figures and discussed.
authors.affiliation: Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, Vilnius 03225, Lithuania. Electronic address: vladas.skakauskas@mif.vu.lt.
authors.forename: Vladas
authors.initials: V
authors.lastname: Skakauskas
authors.affiliation: Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, Vilnius 03225, Lithuania.
authors.forename: Pranas
authors.initials: P
authors.lastname: Katauskis
authors.affiliation: Defence Science and Technology Organisation, 506 Lorimer st., Melbourne, VIC 3207, Australia.
authors.forename: Alex
authors.initials: A
authors.lastname: Skvortsov
authors.affiliation: Defence Science and Technology Organisation, 506 Lorimer st., Melbourne, VIC 3207, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Gray
mesh_terms: D000906:Antibodies / Q000008:administration & dosage; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005057:Eukaryotic Cells; D006801:Humans; D007700:Kinetics; D055641:Mathematical Concepts; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000187:drug effects*; D012276:Ricin / Q000276:immunology / Q000493:pharmacokinetics / Q000633:toxicity; D014118:Toxins, Biological / Q000276:immunology / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000906:Antibodies; D014118:Toxins, Biological; D012276:Ricin
keywords: Antibody; Cell receptor; Protein biosynthesis; Ricin; Toxin