title: Seropositivity of dengue antibodies during pregnancy.
abstract: OBJECTIVE
  Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM) during pregnancy and its neonatal transmission in dengue seropositive women.
  
  
  METHODS
  Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM) using an enzyme-linked immunosorbent assay (ELISA). Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU) were analyzed.
  
  
  RESULTS
  Out of 358 women recruited, about 128 (35.8%) patients were seropositive. Twelve patients (3.4%) had recent infections (IgM positive) and another 116 women (32.4%) were with past infections (IgG positive). All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission.
  
  
  CONCLUSIONS
  In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.
authors.affiliation: Department of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Nor Azlin
authors.initials: NA
authors.lastname: Mohamed Ismail
authors.affiliation: Department of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Wan Elly Rushima
authors.initials: WE
authors.lastname: Wan Abd Rahim
authors.affiliation: Department of Microbiology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Sharifah Azura
authors.initials: SA
authors.lastname: Salleh
authors.affiliation: UKM Medical Molecular Biology Institute, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Neoh
authors.affiliation: UKM Medical Molecular Biology Institute, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Rahman
authors.initials: R
authors.lastname: Jamal
authors.affiliation: Department of Obstetrics & Gynaecology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Muhammad Abdul
authors.initials: MA
authors.lastname: Jamil
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D003715:Dengue / Q000097:blood / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D008296:Malaysia; D011247:Pregnancy; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G