title: Role of the kidney in the fetal programming of adult cardiovascular disease: an update.
abstract: It is well established that an adverse in utero environment can impinge upon fetal development and place the offspring on a track leading to future cardiovascular disease. Significantly, this may occur in the absence of any outward manifestations at birth. In this brief review, we focus on potential renal mechanisms that lead to adaptations in glomerular and tubular function that initiate hypertension of developmental origin and examine potential therapeutic interventions. This report updates recent data in this field.
authors.affiliation: Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Reetu R
authors.initials: RR
authors.lastname: Singh
authors.affiliation: Department of Physiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address: Kate.Denton@monash.edu.
authors.forename: Kate M
authors.initials: KM
authors.lastname: Denton
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology*; D047109:Fetal Development; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000378:metabolism / Q000473:pathology; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium