title: Abnormal resting state FMRI activity predicts processing speed deficits in first-episode psychosis.
abstract: Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N=17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age- and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component analysis (ICA) was used to assess group differences in the expression of rs-fMRI activity within 20 predefined publicly available templates. Patients demonstrated lower overall rs-fMRI global connectivity compared with healthy volunteers without associated group differences in gray matter thickness assessed within the same regions-of-interest used in this analysis. Similarly, ICA revealed worse rs-fMRI expression scores across all 20 networks in patients compared with healthy volunteers, with posthoc analyses revealing significant (p<0.05; corrected) abnormalities within the caudate nucleus and planum temporale. Worse processing speed correlated significantly with overall lower global connectivity using the region-of-interest approach and lower expression scores within the planum temporale using ICA. Our findings implicate dysfunction in rs-fMRI activity in first-episode psychosis prior to extensive antipsychotic treatment using different analytic approaches (in the absence of concomitant gray matter structural differences) that predict processing speed.
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA.
authors.forename: Miklos
authors.initials: M
authors.lastname: Argyelan
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Gallego
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Delbert G
authors.initials: DG
authors.lastname: Robinson
authors.affiliation: Department of Communication Sciences and Disorders, School of Applied Sciences, University of Mississippi, University, MS, USA.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Ikuta
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Sarpal
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Department of Mathematics, Hofstra University, Hempstead, NY, USA.
authors.forename: Majnu
authors.initials: M
authors.lastname: John
authors.affiliation: Department of Radiology, North Shore University Hospital, Manhasset, NY, USA.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Kingsley
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: John
authors.initials: J
authors.lastname: Kane
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
authors.affiliation: 1] Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA [2] Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-LIJ Health System, Glen Oaks, NY, USA [3] Departments of Psychiatry and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Szeszko
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000145:classification / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D025341:Principal Component Analysis; D012146:Rest; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D010100:Oxygen