title: Ten-year mortality risk predictors after primary total knee arthroplasty for osteoarthritis.
abstract: OBJECTIVE
  To determine predictors of mortality up to 10 post-operative years.
  
  
  METHODS
  A cohort of 1,569 consecutive patients who underwent primary cementless total knee arthroplasty (TKA) for osteoarthritis was prospectively evaluated. Patient mortality was compared to the general population using standardized mortality ratios (SMR). The effects on patient mortality and surgical data, as well as post-operative outcomes, were analysed using Cox regression analysis.
  
  
  RESULTS
  The 10-year survival was 88.9% in females and 73.4% in males (p = 0.001). The SMR were higher for females under 50 years (213.1%) and for males over 70 years (170.5%). Aged 70 or older and male gender were predictive for mortality in any post-operative time. Lengthening of the follow-up time showed different patterns of other risk mortality factors. Within 8 years, high Charlson index, poorer post-operative clinical status, and quality of life were also associated with an increased mortality risk, and obesity was protective factor. However, 10-year mortality was only associated with age, female gender, post-operative walking disability, and increasing post-operative WOMAC pain score.
  
  
  CONCLUSIONS
  In this study, patient-related factors that can help identify patients at risk were only age and gender, while recovery of walking ability, WOMAC pain, and SF-12 mental component were important survival factors among post-operative factors. This study identified important patient-related predictors of mortality after TKA, which may be useful in order to inform the patients of the potential risks.
  
  
  METHODS
  IV.
authors.affiliation: Department of Orthopaedic Surgery, Elda University Hospital, Ctra Elda-Sax s/n, 03600, Elda, Alicante, Spain, lizaur1@telefonica.net.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lizaur-Utrilla
authors.forename: Santiago
authors.initials: S
authors.lastname: Gonzalez-Parreño
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Miralles-Muñoz
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Lopez-Prats
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000401:mortality*; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D010147:Pain Measurement; D011788:Quality of Life; D012307:Risk Factors; D012737:Sex Factors