title: Leprosy in the 21st century.
abstract: Despite significant improvements in leprosy (Hansen's disease) treatment and outlook for patients since the introduction of multidrug therapy (MDT) 3 decades ago, the global incidence remains high, and patients often have long-term complications associated with the disease. In this article, we discuss recent findings related to genetics, susceptibility, and disease reservoirs and the implications of these findings for Hansen's disease control and health outcomes for patients. We describe the continued difficulties associated with treatment of inflammatory episodes known as "leprosy reactions," which cause much of the disability associated with the disease and can affect people for many years after MDT is complete. We also discuss some of the contemporary challenges for physicians and patients, including international and internal migration of people affected by the disease. We suggest some important areas of focus for future Hansen's disease research.
authors.affiliation: Department of Anthropology, Georgia State University, Atlanta, Georgia, USA cwhite@gsu.edu.
authors.forename: Cassandra
authors.initials: C
authors.lastname: White
authors.affiliation: Hospital Infantil de México, Federico Gómez, México City, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Franco-Paredes
mesh_terms: D000818:Animals; D001135:Armadillos / Q000382:microbiology; D004197:Disease Reservoirs; D004198:Disease Susceptibility; D006801:Humans; D015994:Incidence; D007918:Leprosy / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control / Q000635:transmission; D012307:Risk Factors