title: Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1.
abstract: OBJECTIVE
  Currently, little is known about the prevalence of thyroid tumors in multiple endocrine neoplasia type 1 (MEN1) patients and it is unclear whether tumorigenesis of these thyroid tumors is MEN1-related. The aim of the study was to assess the prevalence of thyroid incidentalomas in MEN1 patients compared with nonMEN1 patients and to verify whether thyroid tumorigenesis is MEN1-related.
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  The study included two groups: patients with MEN1 and a matched non-MEN1 control group without known thyroid disease, who underwent an ultrasound of the neck for the localization of parathyroid adenoma. Ninety-five MEN1 patients underwent ultrasound of the neck and were matched on gender and age with non-MEN1 patients. The prevalence of thyroid incidentalomas described in the ultrasound report was scored. Multinodular goiters, solitary nodes, and cysts were scored as incidentalomas. Presence of nuclear menin expression was evaluated by menin immunostaining of the thyroid tumors.
  
  
  RESULTS
  In the MEN1 group, 43 (45%) patients had a thyroid incidentaloma compared with 48 (51%) in the non-MEN1 group, of which 14 (15%) and 16 (17%), respectively, were solitary nodes. Menin was expressed in the nuclei of all evaluated thyroid tumors.
  
  
  CONCLUSIONS
  MEN1 patients do not have a higher prevalence of thyroid incidentalomas compared with primary hyperparathyroidism patients without the diagnosis of MEN1. Menin was expressed in the thyroid tumors of MEN1 patients.
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Lutske
authors.initials: L
authors.lastname: Lodewijk
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Pim J
authors.initials: PJ
authors.lastname: Bongers
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Jakob W
authors.initials: JW
authors.lastname: Kist
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Elfi B
authors.initials: EB
authors.lastname: Conemans
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: de Laat
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Carla R C
authors.initials: CR
authors.lastname: Pieterman
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Anouk N A
authors.initials: AN
authors.lastname: van der Horst-Schrivers
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Ciska
authors.initials: C
authors.lastname: Jorna
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Ad R
authors.initials: AR
authors.lastname: Hermus
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Olaf M
authors.initials: OM
authors.lastname: Dekkers
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Wouter W
authors.initials: WW
authors.lastname: de Herder
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Madeleine L
authors.initials: ML
authors.lastname: Drent
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Bisschop
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Havekes
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Inne H M Borel
authors.initials: IH
authors.lastname: Rinkes
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.
authors.forename: Menno R
authors.initials: MR
authors.lastname: Vriens
authors.affiliation: Department of OncologyUniversity Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsDepartments of Endocrinology and SurgeryUniversity Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of EndocrinologyRadboud University Medical Center, 6500 HB Nijmegen, The NetherlandsDepartments of Endocrinology and Metabolism and Clinical EpidemiologyLeiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal MedicineErasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Internal MedicineVU University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Endocrinology and MetabolismAcademic Medical Center, 1100 DD Amsterdam, The NetherlandsDepartment of Internal MedicineDivision of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands G.D.Valk@umcutrecht.nl.
authors.forename: Gerlof D
authors.initials: GD
authors.lastname: Valk
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000000981:diagnostic imaging / Q000453:epidemiology*; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism; D014463:Ultrasonography; D055815:Young Adult
chemical_list: C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins