title: Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics.
abstract: Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × ΦF) and relaxivity R1) and fluorescence confocal/biphoton microscopy studies were conducted.
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302 CNRS-Université de Bourgogne, BP 47870, F-21078, Dijon Cedex, France. Richard.Decreau@u-bourgogne.fr.
authors.forename: Yann
authors.initials: Y
authors.lastname: Bernhard
authors.forename: Pascale
authors.initials: P
authors.lastname: Winckler
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Perrier-Cornet
authors.forename: Richard A
authors.initials: RA
authors.lastname: Decréau
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism; D054833:Isoindoles; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008546:Melanoma, Experimental / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007211:Indoles; D054833:Isoindoles; D008670:Metals; D014867:Water; C013647:phthalocyanine