title: Multiple myeloma: is a shift toward continuous therapy needed to move forward?
abstract: Multiple myeloma (MM) accounts for 1% of all cancers and 13% of all hematologic malignancies. Melphalan-prednisone plus melphalan-prednisone-thalidomide or melphalan-prednisone-bortezomib are considered the standards of care for newly diagnosed, transplant-ineligible patients with MM (older than 65 years). In newly diagnosed, transplant-eligible patients with MM (younger than 65 years), a novel agent-based induction followed by high-dose therapy and autologous stem cell transplantation, is the standard approach. The availability of novel agents has considerably increased the treatment options of this disease, but almost all patients relapse after achieving a maximal response to first-line therapy. New drugs and new treatment approaches are urgently needed to improve outcome in MM patients Continuous therapy can be a valid option to keep the patient symptom-free and to prolong progression-free survival and overall survival.
authors.affiliation: Unit of Hematology, 'S. Luigi Gonzaga' Hospital, Orbassano, Italy.
authors.forename: Tommasina
authors.initials: T
authors.lastname: Guglielmelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Palumbo
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000069286:Bortezomib / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D000077269:Lenalidomide; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D033581:Stem Cell Transplantation; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D013792:Thalidomide; D000069286:Bortezomib; D000077269:Lenalidomide
keywords: bortezomib; continuous therapy; lenalidomide; maintenance; multiple myeloma; thalidomide