title: A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS).
abstract: Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In addition, in the pathogenesis of cancer, inflammation, arthritis, and connective tissue diseases, ADAMTS proteinases have crucial roles. The purpose of this review is to collect previous studies about obstetrics and gynecology that are related to ADAMTS enzymes and discuss the subject in many aspects to give an idea to the investigators who are interested in the subject.
authors.affiliation: Department of Medical Biology, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Demircan
authors.affiliation: Department of Medical Genetics, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Cömertoğlu
authors.affiliation: Department of Medical Biology, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Sümeyya
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Medical Genetics, Turgut Özal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Beyza Nur
authors.initials: BN
authors.lastname: Yiğitoğlu
authors.affiliation: Department of Reproductive Endocrinology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey ; Department of Obstetrics and Gynecology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Sarıkaya
keywords: ADAMTS; biological marker; reproductive diseases