title: Dietary Iron and Colorectal Cancer Risk: A Review of Human Population Studies.
abstract: Iron is an essential micronutrient that is involved in many redox processes and serves as an integral component in various physiological functions. However, excess iron can cause tissue damage through its pro-oxidative effects, potentiating the development of many diseases such as cancer through the generation of reactive oxidative species. The two major forms of iron in the diet are heme and nonheme iron, both of which are found in several different foods. In addition to natural food sources, intake of nonheme iron may also come from fortified foods or in supplement form. This review summarizes the results of human population studies that have examined the role of dietary iron (heme and nonheme), heme iron alone, and iron from supplements in colorectal carcinogenesis.
authors.affiliation: a Department of Pharmaceutical Sciences , Washington State University , Spokane , Washington , USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Ashmore
authors.affiliation: b Department of Nutritional Sciences , Pennsylvania State University , University Park , Pennsylvania , USA.
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Rogers
authors.affiliation: b Department of Nutritional Sciences , Pennsylvania State University , University Park , Pennsylvania , USA.
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Kelleher
authors.affiliation: c Northeast Regional Cancer Institute , Scranton , Pennsylvania , USA.|d The Commonwealth Medical College , Scranton , Pennsylvania , USA.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Lesko
authors.affiliation: e Department of Epidemiology , Rollins School of Public Health and Winship Cancer Institute, Emory University , Atlanta , Georgia , USA.
authors.forename: Terryl J
authors.initials: TJ
authors.lastname: Hartman
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D004032:Diet; D019587:Dietary Supplements; D005527:Food, Fortified; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage*; D012307:Risk Factors
chemical_list: D019266:Iron, Dietary
keywords: Iron; colorectum; heme; supplements