title: Asymmetric α-benzoyloxylation of β-ketocarbonyls by a chiral primary amine catalyst.
abstract: The direct asymmetric α-benzoyloxylation of β-ketocarbonyls catalyzed by a chiral primary amine is described herein. This protocol demonstrates excellent enantioselectivity for a broad range of substrates, which allows convenient access to highly enantioenriched α-hydroxy-β-ketocarbonyls.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.
authors.forename: Dehong
authors.initials: D
authors.lastname: Wang
authors.forename: Changming
authors.initials: C
authors.lastname: Xu
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001585:Benzoyl Peroxide / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D007659:Ketones; D001585:Benzoyl Peroxide