title: Culture medium-associated physicochemical insights on the cytotoxicity of carbon nanomaterials.
abstract: Carbon nanomaterials are the most studied materials in nanotechnology. There have been numerous studies on cytotoxicity assessments of carbon nanomaterials, which, however, often lead to controversy. It is generally considered that chemical and physical properties of carbon nanomaterials should have specific biological outcomes. More recent studies have identified the significance of environmental factors surrounding nanomaterial-treated cells. In this perspective, we mainly review culture medium-associated physicochemical insights on the cytotoxicity of carbon nanomaterials, which are largely based on studies in our laboratory. These studies established the close relationship and interplay among the physicochemical properties of the nanomaterials, culture medium, and their toxicological responses.
authors.affiliation: Division of Physical Biology, and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai 201800, China.
authors.forename: Huating
authors.initials: H
authors.lastname: Kong
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry* / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D003470:Culture Media; D002244:Carbon