title: [Chronobiological characteristics of stroke and poststroke cognitive impairment].
abstract: OBJECTIVE
  To study chronobiological characteristics of ischemic stroke (II) and post stroke cognitive impairment (CI).
  
  
  METHODS
  We examined 80 patients with acute ischemic stroke. The cognitive status, sleep quality, chronobiological parameters and night urinary level of 6-sulfatoxymelatonin were assessed. The clinical observation of the efficacy of melaxen treatment in intensive care unit was performed.
  
  
  RESULTS
  The results of the study indicate the significance of social and environmental factors which determine the sleep-wake behavior in the development of pineal dysfunction. The pineal dysfunction probably underlies the development of stroke and accompanied neurodegenerative process.
  
  
  CONCLUSIONS
  The use of melaxen in hyperacute stroke was associated with better recovery of circadian rhythms and rehabilitation results.
authors.forename: A A
authors.initials: AA
authors.lastname: Kulesh
authors.forename: T V
authors.initials: TV
authors.lastname: Lapaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Shestakov
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy; D002940:Circadian Rhythm; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000652:urine; D008875:Middle Aged; D010870:Pineal Gland / Q000503:physiopathology; D012890:Sleep; D020521:Stroke / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin