title: Polymeric-based particulate systems for delivery of therapeutic proteins.
abstract: Polymeric-based particulate systems have been intensively developed to increase the short biological half-life and prevent enzymatic degradation of therapeutic proteins. These techniques demonstrate the useful characteristics for the delivery of therapeutic proteins and peptides to the targeted site of application and prevent the interaction of encapsulated drug with the normal cells. In this article, we have described the in depth of different pharmaceutical-based techniques that are currently being practiced for efficient delivery of therapeutic proteins and peptides. A comprehensive English literature was searched using different electronic search databases including PubMed, Science Direct, Web of Science, google scholar and library search. Different search terms and advanced search were made by combining all the search fields in abstract, keywords and/or titles. Findings of various studies that have been discussed in this article clearly indicate that polymeric-based techniques can significantly increase the therapeutic potentials of incorporated proteins with no known toxic effects. These techniques have shown to maintain the stability and retain biological activity of protein therapeutics. Hence it can be suggested that pharmaceutical-based techniques are promising drug carriers for efficient delivery of therapeutic proteins.
authors.affiliation: a Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , China .|b Faculty of Pharmaceutical Sciences , Government College University Faisalabad , Faisalabad , Pakistan , and.
authors.forename: Muhammad Sajid Hamid
authors.initials: MS
authors.lastname: Akash
authors.affiliation: b Faculty of Pharmaceutical Sciences , Government College University Faisalabad , Faisalabad , Pakistan , and.|c Department of Toxicology , School of Medicine and Public Health, Zhejiang University , Hangzhou , China.
authors.forename: Kanwal
authors.initials: K
authors.lastname: Rehman
authors.affiliation: a Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , China .
authors.forename: Shuqing
authors.initials: S
authors.lastname: Chen
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D004355:Drug Stability; D006801:Humans; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D011506:Proteins
keywords: Hydrogel; liposomes; micelles; nanoparticles; polymeric-based technology; therapeutic proteins; thermosensitive gels