title: Systems approaches to unravel innate immune cell diversity, environmental plasticity and functional specialization.
abstract: Innate immune cells are generated through central and peripheral differentiation pathways, and receive multiple signals from tissue microenvironment. The complex interplay between immune cell state and environmental signals is crucial for the adaptation and efficient response to pathogenic threats. Here, we discuss how systems biology approaches have brought global view and high resolution to the characterization of (1) immune cell diversity, (2) phenotypic, transcriptional and functional changes in response to environmental signals, (3) integration of multiple stimuli. We will mostly focus on systems level studies in dendritic cells and macrophages. Generalization of these approaches should elucidate innate immune cell diversity and plasticity, and may be used in the human to generate hypothesis on cell filiation and novel strategies for immunotherapy.
authors.affiliation: Integrative Biology of Human Dendritic Cells and T Cells Laboratory, U932 Immunity and Cancer, Institut Curie, 26 Rue d'Ulm, 75005 Paris, France. Electronic address: vassili.soumelis@curie.fr.
authors.forename: Vassili
authors.initials: V
authors.lastname: Soumelis
authors.affiliation: Integrative Biology of Human Dendritic Cells and T Cells Laboratory, U932 Immunity and Cancer, Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.
authors.forename: Lucia
authors.initials: L
authors.lastname: Pattarini
authors.affiliation: Integrative Biology of Human Dendritic Cells and T Cells Laboratory, U932 Immunity and Cancer, Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.
authors.forename: Paula
authors.initials: P
authors.lastname: Michea
authors.affiliation: Integrative Biology of Human Dendritic Cells and T Cells Laboratory, U932 Immunity and Cancer, Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cappuccio
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000378:metabolism