title: An easy-to-detect nona-arginine peptide for epidermal targeting.
abstract: A correlative approach combining synchrotron radiation based IR microscopy and fluorescence microscopy enabled the successful detection and quantification of a nona-arginine peptide labelled with a Single Core Multimodal Probe for Imaging (SCoMPI) in skin biopsies. The topical penetration of the conjugate appeared to be time dependent and occurred most probably via the extracellular matrix.
authors.affiliation: Ecole Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités - UPMC Univ Paris 06, UMR 7203 CNRS-ENS-UPMC LBM, 24, rue Lhomond, 75005 Paris, France. clotilde.policar@ens.fr.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Clède
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delsuc
authors.forename: Cécile
authors.initials: C
authors.lastname: Laugel
authors.forename: François
authors.initials: F
authors.lastname: Lambert
authors.forename: Christophe
authors.initials: C
authors.lastname: Sandt
authors.forename: Arlette
authors.initials: A
authors.lastname: Baillet-Guffroy
authors.forename: Clotilde
authors.initials: C
authors.lastname: Policar
mesh_terms: D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D009842:Oligopeptides / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D012867:Skin / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D009842:Oligopeptides; D010455:Peptides; C491427:nonaarginine