title: Mapping longitudinal studies to risk factors in an ontology for dementia.
abstract: A common activity carried out by healthcare professionals is to test various hypotheses on longitudinal study data in an effort to develop new and more reliable algorithms that might determine the possibility of developing certain illnesses. The INnovative, Midlife INtervention for Dementia Deterrence project provides input from a number of European dementia experts to identify the most accurate model of inter-related risk factors which can yield a personalized dementia-risk quotient and profile. This model is then validated against the large population-based prospective Maastricht Aging Study dataset. As part of this overall goal, the research presented in this article demonstrates how we can automate the process of mapping modifiable risk factors against large sections of the aging study and thus use information technology to provide more powerful query interfaces.
authors.affiliation: Dublin City University, Ireland.
authors.forename: Mark
authors.initials: M
authors.lastname: Roantree
authors.affiliation: Dublin City University, Ireland jodonoghue@computing.dcu.ie.
authors.forename: Jim
authors.initials: J
authors.lastname: O' Donoghue
authors.affiliation: Dublin City University, Ireland.
authors.forename: Noel
authors.initials: N
authors.lastname: O' Kelly
authors.affiliation: Dublin City University, Ireland.
authors.forename: Maria
authors.initials: M
authors.lastname: Pierce
authors.affiliation: Dublin City University, Ireland.
authors.forename: Kate
authors.initials: K
authors.lastname: Irving
authors.affiliation: Maastricht University, Netherlands.
authors.forename: Martin
authors.initials: M
authors.lastname: Van Boxtel
authors.affiliation: Maastricht University, Netherlands.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Köhler
mesh_terms: D000375:Aging; D000465:Algorithms; D016208:Databases, Factual; D003704:Dementia / Q000175:diagnosis*; D005060:Europe; D006801:Humans; D008137:Longitudinal Studies; D008490:Medical Informatics; D011446:Prospective Studies; D012307:Risk Factors
keywords: dementia; modifiable risk factors; ontology; word matching