title: A surprising role for the Sch9 protein kinase in chromosome segregation in Candida albicans.
abstract: The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.
authors.affiliation: Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Varshney
authors.affiliation: Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universität, Düsseldorf, Germany Manchot Graduate School Molecules of Infection, Heinrich-Heine-Universität, Düsseldorf 40225, Germany.
authors.forename: Alida
authors.initials: A
authors.lastname: Schaekel
authors.affiliation: Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
authors.forename: Rima
authors.initials: R
authors.lastname: Singha
authors.affiliation: Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Chakraborty
authors.affiliation: Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universität, Düsseldorf, Germany Manchot Graduate School Molecules of Infection, Heinrich-Heine-Universität, Düsseldorf 40225, Germany.
authors.forename: Lasse
authors.initials: L
authors.lastname: van Wijlick
authors.affiliation: Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universität, Düsseldorf, Germany Manchot Graduate School Molecules of Infection, Heinrich-Heine-Universität, Düsseldorf 40225, Germany joachim.ernst@uni-duesseldorf.de sanyal@jncasr.ac.in.
authors.forename: Joachim F
authors.initials: JF
authors.lastname: Ernst
authors.affiliation: Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India joachim.ernst@uni-duesseldorf.de sanyal@jncasr.ac.in.
authors.forename: Kaustuv
authors.identifier: http://orcid.org/0000-0002-6611-4073
authors.initials: K
authors.lastname: Sanyal
mesh_terms: D002176:Candida albicans / Q000235:genetics*; D002503:Centromere; D020090:Chromosome Segregation; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D011494:Protein Kinases; C071569:SCH9 protein kinase
keywords: Sch9; centromere; chromosome segregation; kinase; kinetochore