title: 14-3-3 proteins in plant-pathogen interactions.
abstract: 14-3-3 proteins define a eukaryotic-specific protein family with a general role in signal transduction. Primarily, 14-3-3 proteins act as phosphosensors, binding phosphorylated client proteins and modulating their functions. Since phosphorylation regulates a plethora of different physiological responses in plants, 14-3-3 proteins play roles in multiple signaling pathways, including those controlling metabolism, hormone signaling, cell division, and responses to abiotic and biotic stimuli. Increasing evidence supports a prominent role of 14-3-3 proteins in regulating plant immunity against pathogens at various levels. In this review, potential links between 14-3-3 function and the regulation of plant-pathogen interactions are discussed, with a special focus on the regulation of 14-3-3 proteins in response to pathogen perception, interactions between 14-3-3 proteins and defense-related proteins, and 14-3-3 proteins as targets of pathogen effectors.
authors.affiliation: 1The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, U.K.;|2Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, 3888 Chenhua Rd, Shanghai 201602, China.
authors.forename: Rosa
authors.initials: R
authors.lastname: Lozano-Durán
authors.affiliation: 1The Sainsbury Laboratory, Norwich Research Park, NR4 7UH Norwich, U.K.;
authors.forename: Silke
authors.initials: S
authors.lastname: Robatzek
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D054884:Host-Pathogen Interactions; D008954:Models, Biological; D010766:Phosphorylation; D010802:Phylogeny; D010935:Plant Diseases / Q000276:immunology* / Q000382:microbiology; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D048948:14-3-3 Proteins; D010940:Plant Proteins