title: Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236).
abstract: BACKGROUND
  Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor. The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.
  
  
  METHODS
  Rs10735810, rs1544410, rs7975232, and rs731236 polymorphisms of VDR, the serum sex hormone level, free estrogen index (FEI) and free androgen index (FAI) as well as vitamin D, were evaluated in 766 persons (362 women and 404 men) selected from 5695 Polish population, aged 65-90years from the PolSenior survey.
  
  
  RESULTS
  We observed that women with GG (rs731236), TT (rs7975232), BB (rs1544410) and FF (rs10735810) genotypes were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism and in the GG (rs7975232), the BB (rs1544410), and the Ff (rs10735810) genotypes.
  
  
  CONCLUSIONS
  In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed.
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland. Electronic address: Lukasz.laczmanski@umed.wroc.pl.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Laczmanski
authors.affiliation: Department of Health Promotion, Faculty of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
authors.forename: Felicja
authors.initials: F
authors.lastname: Lwow
authors.affiliation: PolSenior Project, International Institute of Molecular and Cell Biology, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Mossakowska
authors.affiliation: Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Puzianowska-Kuznicka
authors.affiliation: Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szwed
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kolackov
authors.affiliation: Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Krzyzanowska-Swiniarska
authors.affiliation: Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Bar-Andziak
authors.affiliation: Department of Pathophysiology, Medical University of Silesia, Katowice, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Sloka
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004967:Estrogens / Q000097:blood*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D011044:Poland; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D013739:Testosterone / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
chemical_list: D004967:Estrogens; D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014807:Vitamin D; D013739:Testosterone
keywords: Aging; FAI; Testosterone level; VDR polymorphism; Vitamin D level