title: Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity.
abstract: The aim of this study was to analyze the effects of a 4-week-long consumption of glucomannan-enriched, aronia juice-based supplement on anthropometric parameters, membrane fatty acid profile, and status of antioxidant enzymes in erythrocytes obtained from postmenopausal women with abdominal obesity. Twenty women aged 45-65 with a mean body mass index (BMI) of 36.1 ± 4.4 kg/m(2) and waist circumference of 104.8 ± 10.1 cm were enrolled. Participants were instructed to consume 100 mL of supplement per day as part of their regular diet. A significant increase in the content of n-3 (P < 0.05) polyunsaturated fatty acids in membrane phospholipids was observed, with a marked increase in the level of docosahexaenoic fatty acid (P < 0.05). Accordingly, a decrease in the n-6 and n-3 fatty acids ratio was observed (P < 0.05). The observed effects were accompanied with an increase in glutathione peroxidase activity (P < 0.05). Values for BMI (P < 0.001), waist circumference (P < 0.001), and systolic blood pressure (P < 0.05) were significantly lower after the intervention. The obtained results indicate a positive impact of tested supplement on cellular oxidative damage, blood pressure, and anthropometric indices of obesity.
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Nevena
authors.identifier: 0000-0001-6931-3695
authors.initials: N
authors.lastname: Kardum
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Petrović-Oggiano
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Marija
authors.identifier: 0000-0001-8449-165X
authors.initials: M
authors.lastname: Takic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Natalija
authors.initials: N
authors.lastname: Glibetić
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Manja
authors.initials: M
authors.lastname: Zec
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Debeljak-Martacic
authors.affiliation: Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Drive Subotića 4, 11000 Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Konić-Ristić
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001628:Beverages; D019587:Dietary Supplements; D004912:Erythrocytes / Q000201:enzymology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D008351:Mannans / Q000627:therapeutic use*; D008563:Membrane Lipids / Q000378:metabolism*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000188:drug therapy* / Q000201:enzymology; D046936:Photinia / Q000737:chemistry*; D008517:Phytotherapy
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D008351:Mannans; D008563:Membrane Lipids; C022901:(1-6)-alpha-glucomannan