title: Luteolin attenuate the D-galactose-induced renal damage by attenuation of oxidative stress and inflammation.
abstract: Luteolin is reported to have antioxidant and anti-inflammatory properties. In this study, we investigated the protective effect of luteolin against the renal damage induced by D-galactose (D-gal). The levels of creatinine (Cr) and urea nitrogen (BUN) were evaluated in plasma, kidney sections were stained with haematoxylin-eosin, followed by assessment of the antioxidant and anti-inflammatory activity. Furthermore, we also investigated the expression of the p38 mitogen-activated protein kinase (p38 MAPK) and its phosphorylated activation. The results of luteolin treatment showed that the renal damages were attenuated. Luteolin could significantly ameliorate D-gal-induced oxidative damage and suppress the inflammatory response. Moreover, the result also shows that luteolin could significantly inhibit the p38 MAPK phosphorylation in the kidneys from the model of D-gal-treated mice. Therefore, our research suggests that luteolin might be involved in the attenuated oxidative stress and inflammatory responses, hence the protective effects against D-gal-induced renal damage.
authors.affiliation: a School of Pharmacy , Xuzhou Medical College , 84 West Huaihai Road, Xuzhou , Jiangsu 221002 , PR China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Xu
authors.forename: Jingzheng
authors.initials: J
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Sai
authors.initials: S
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005690:Galactose / Q000009:adverse effects; D007249:Inflammation / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D047311:Luteolin / Q000494:pharmacology*; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D003404:Creatinine; D048051:p38 Mitogen-Activated Protein Kinases; D047311:Luteolin; D005690:Galactose
keywords: d-galactose; inflammation; kidney; luteolin; oxidative stress