title: Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at the C-4 position of oxazoles.
abstract: A facile synthesis of 4-aryl substituted oxazolo[4,5-c]quinolines has been described via a modified Pictet-Spengler method and using Cu(TFA)2 as a catalyst. The developed methodology directly functionalizes the C-4 position of oxazoles without the aid of any prefunctionalization, in the presence of the more reactive C-2 position in good yields. The versatility of the established method has been demonstrated by its application in the synthesis of 4-substituted oxazolo-[1,8]naphthyridine ring systems.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science-Pilani (Hyderabad Campus), Hyderabad-500078, India. anupam@hyderabad.bits-pilani.ac.in.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Akula
authors.forename: Yadagiri
authors.initials: Y
authors.lastname: Thigulla
authors.forename: Connor
authors.initials: C
authors.lastname: Davis
authors.forename: Mukund
authors.initials: M
authors.lastname: Jha
authors.forename: Anupam
authors.initials: A
authors.lastname: Bhattacharya
mesh_terms: D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010080:Oxazoles; D011804:Quinolines