title: Spectral analysis of resting state magnetoencephalogram activity in patients with bipolar disorder.
abstract: We analyzed the frequency spectrum of magnetoencephalogram (MEG) background activity in 16 bipolar disorder (BD) patients and 24 age-matched healthy control. Median frequency (MF), spectral entropy (SpEn), and relative power in delta (RPδ), theta (RPθ), alpha (RPα), beta (RPβ), and gamma (RPγ) bands were computed for all 148 MEG channels. Significant differences between the two groups were found in the average level of MF, RPδ, and RPθ in the posterior region of the scalp. Moreover, the MF, SpEn, RPδ, and RPβ values of BD patients had a different dependence on age as compared with the results of control subjects, which may suggest that BD affects how the brain activity develops with age. We conclude that the spectral analysis of the background MEG in BD patients may give insights into how this condition affects the brain activity.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Al-Timemy
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez
authors.forename: Javier
authors.initials: J
authors.lastname: Escudero
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted