title: Antibiotic management of complicated intra-abdominal infections in adults: The Asian perspective.
abstract: Regional epidemiological data and resistance profiles are essential for selecting appropriate antibiotic therapy for intra-abdominal infections (IAIs). However, such information may not be readily available in many areas of Asia and current international guidelines on antibiotic therapy for IAIs are for Western countries, with the most recent guidance for the Asian region dating from 2007. Therefore, the Asian Consensus Taskforce on Complicated Intra-Abdominal Infections (ACT-cIAI) was convened to develop updated recommendations for antibiotic management of complicated IAIs (cIAIs) in Asia. This review article is based on a thorough literature review of Asian and international publications related to clinical management, epidemiology, microbiology, and bacterial resistance patterns in cIAIs, combined with the expert consensus of the Taskforce members. The microbiological profiles of IAIs in the Asian region are outlined and compared with Western data, and the latest available data on antimicrobial resistance in key pathogens causing IAIs in Asia is presented. From this information, antimicrobial therapies suitable for treating cIAIs in patients in Asian settings are proposed in the hope that guidance relevant to Asian practices will prove beneficial to local physicians managing IAIs.
authors.affiliation: Infectious Diseases Care, #03-01 Mount Elizabeth Medical Centre, Singapore 228510, Singapore.
authors.forename: Asok
authors.initials: A
authors.lastname: Kurup
authors.affiliation: Nexus Surgical Associates Pte Ltd, Mount Elizabeth Novena Specialist Centre, 38 Irrawaddy Road, Singapore 329563, Singapore.
authors.forename: Kui-Hin
authors.initials: KH
authors.lastname: Liau
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan ; Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Min-Chi
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Faculty of Medicine and Surgery, University of Santo Tomas, Espana Boulevard, Manila 1008, Philippines.
authors.forename: Narciso S
authors.initials: NS
authors.lastname: Navarro
authors.affiliation: Department of Surgery, Service Institute of Medical Sciences, Lahore, Punjab, Pakistan.
authors.forename: Muhammad Waris
authors.initials: MW
authors.lastname: Farooka
authors.affiliation: Hasan Sadikin Hospital, Department of Surgery, 38 Pasteur Street, Bandung, West Java, 40136, Indonesia.
authors.forename: Nurhayat
authors.initials: N
authors.lastname: Usman
authors.affiliation: National Institutes of Health, University of the Philippines Manila, Pedro Gil Street, Ermita Manila 1000, Philippines.
authors.forename: Raul V
authors.initials: RV
authors.lastname: Destura
authors.affiliation: Division of General Surgery, Department of Surgery, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
authors.forename: Boonchoo
authors.initials: B
authors.lastname: Sirichindakul
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Chulalongkorn University, Rama 4 Rd, Phatumwan, Bangkok 10330, Thailand.
authors.forename: Terapong
authors.initials: T
authors.lastname: Tantawichien
authors.affiliation: Department of Medicine, Sungai Buloh Hospital, Jalan Hospital, Sungai Buloh 47000, Malaysia.
authors.forename: Christopher K C
authors.initials: CK
authors.lastname: Lee
authors.affiliation: Department of Surgery, University of Cincinnati College of Medicine, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0558, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Solomkin
keywords: Antibiotics; Asia; Epidemiology; Intra-abdominal infection; Microbiology; Resistance