title: [An impact of neuroprotective therapy on blood rheological and morphodensitometric parameters in patients with chronic cerebral ischemia].
abstract: OBJECTIVE
  To explore the dynamics of aggregation of platelets and erythrocytes, their deformity and computed morphodensitometric parameters in patients with chronic cerebral ischemia, stages I and II, treated with cerebrolysin.
  
  
  METHODS
  We examined 300 patients, including 87 men and 213 women, aged from 30 to 55 years. Patients were randomized by disease stage and treatment (standard treatment with or without cerebrolysin). The dynamics of neurological and emotional status as well as cognitive functions and results of laboratory studies were assessed.
  
  
  CONCLUSIONS
  Along with the total positive effect of cerebrolysin on the clinical picture, additional mechanisms of its action (antiaggregant, antihypoxic and membranotropic) improved the erythrocyte morphodensitometric parameters, hemostatic, hemorheological and blood gas transport characteristics, in particular on the microcirculatory level.
authors.forename: A V
authors.initials: AV
authors.lastname: Anisimova
authors.forename: T I
authors.initials: TI
authors.lastname: Kolesnikova
authors.forename: E V
authors.initials: EV
authors.lastname: Iutskova
authors.forename: S S
authors.initials: SS
authors.lastname: Galkin
authors.forename: I A
authors.initials: IA
authors.lastname: Zimin
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000627:therapeutic use*; D001792:Blood Platelets / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D018056:Hemorheology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin