title: Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential.
abstract: Light offers unique advantages for studying and manipulating biomolecules and the cellular processes that they control. Optical control of ionotropic and metabotropic glutamate receptors has garnered significant interest, since these receptors are central to signaling at neuronal synapses and only optical approaches provide the spatial and temporal resolution required to directly probe receptor function in cells and tissue. Following the classical method of glutamate photo-uncaging, recently developed methods have added other forms of remote control, including those with high molecular specificity and genetic targeting. These tools open the door to the direct optical control of synaptic transmission and plasticity, as well as the probing of native receptor function in intact neural circuits.
authors.affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, United States.
authors.forename: Andreas
authors.initials: A
authors.lastname: Reiner
authors.affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, United States.
authors.forename: Joshua
authors.initials: J
authors.lastname: Levitz
authors.affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, United States; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, United States; Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States. Electronic address: ehud@berkeley.edu.
authors.forename: Ehud Y
authors.initials: EY
authors.lastname: Isacoff
mesh_terms: D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008027:Light; D009473:Neuronal Plasticity / Q000502:physiology; D058468:Receptors, Ionotropic Glutamate / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D058468:Receptors, Ionotropic Glutamate; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid