title: Diagnostic utility of quantitative EEG in un-medicated schizophrenia.
abstract: The aim of the current study was to evaluate the quantitative electroencephalography (QEEG) characteristics of patients with un-medicated schizophrenia (SPR) and to investigate the diagnostic utility of QEEG in assessing such patients during resting conditions. The subjects included 90 patients with schizophrenia and 90 normal controls. Spectral analysis was performed on the absolute power of all of the electrodes across five frequency bands following artifact removal. We conducted a repeated-measures ANOVA to examine group differences within the five frequency bands across several brain regions and receiver operator characteristic (ROC) analyses to examine the discrimination ability of each frequency band. Compared with controls, patients with schizophrenia showed increased delta and theta activity and decreased alpha 2 activity, particularly in the frontocentral area. There were no significant differences in the alpha 1 and beta activity. The ROC analysis performed on the delta frequency band generated the best result, with an overall classification accuracy of 62.2%. The results of this study confirmed the characteristics of the QEEG power in un-medicated schizophrenia patients compared with normal controls. These findings suggest that a resting EEG test can be a supportive tool for evaluating patients with schizophrenia.
authors.affiliation: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Psychiatry, Graduate School, Chung-Ang University, Seoul, South Korea.
authors.forename: Jun Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea. Electronic address: hawkeyelys@hanmail.net.
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea.
authors.forename: Doug Hyun
authors.initials: DH
authors.lastname: Han
authors.affiliation: Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea.
authors.forename: Kyung Joon
authors.initials: KJ
authors.lastname: Min
authors.affiliation: Addiction Brain Center, Eulji Addiction Institute, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea.
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea.
authors.forename: Kounseok
authors.initials: K
authors.lastname: Lee
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D055815:Young Adult
keywords: Discrimination ability; Quantitative electroencephalography; Spectral analysis; Un-medicated schizophrenia