title: Audiologic impairment associated with bilirubin-induced neurologic damage.
abstract: Hyperbilirubinemia occurs commonly in neonates and is usually mild and transient, with no long-lasting sequelae. However, bilirubin-induced neurologic damage may occur in some infants. The auditory pathway is the most sensitive part of the central nervous system to bilirubin-induced toxicity, and permanent sequelae may result from only moderately elevated total serum/plasma bilirubin levels. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA.
authors.forename: Cristen
authors.initials: C
authors.lastname: Olds
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA. Electronic address: joghalai@stanford.edu.
authors.forename: John S
authors.initials: JS
authors.lastname: Oghalai
mesh_terms: D016057:Evoked Potentials, Auditory, Brain Stem; D006311:Hearing Disorders / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D007647:Kernicterus / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
keywords: Auditory brainstem response; Auditory neuropathy; Bilirubin; Hyperbilirubinemia; Kernicterus