title: Diffuse Interstitial Pulmonary Infiltrates in Malignant Melanoma.
abstract: Only a few cases of sarcoidosis-like reaction to a pharmacologic compound have been reported in patients with melanoma in the literature. Long-term treatment with interferon alpha may be assumed. We report a case of a 25-y-old man who presented to our department with diffuse interstitial pulmonary infiltrates and slightly enlarged mediastinal lymph nodes as determined by computed tomography. He had a history of malignant melanoma with 18 months of interferon alpha-2 therapy. Histological analysis of a transbronchial biopsy revealed sarcoidosis-like reactions.
authors.affiliation: Department of Pulmonary Medicine, University of Leipzig, Leipzig, Germany. highflow@web.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Bräunlich
authors.affiliation: Department of Pulmonary Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Seyfarth
authors.affiliation: Department of Pulmonary Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Armin
authors.initials: A
authors.lastname: Frille
authors.affiliation: Department of Pulmonary Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Hubert
authors.initials: H
authors.lastname: Wirtz
mesh_terms: D000328:Adult; D001706:Biopsy; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008482:Mediastinum; D008545:Melanoma / Q000150:complications* / Q000473:pathology
keywords: drug reactions; interferon alpha-2; melanoma; rare lung diseases; sarcoidosis-like reactions