title: Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines.
abstract: A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.
authors.affiliation: Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune, Maharashtra, India 411008.
authors.forename: Ravindra D
authors.initials: RD
authors.lastname: Aher
authors.forename: B Senthil
authors.initials: BS
authors.lastname: Kumar
authors.forename: Arumugam
authors.initials: A
authors.lastname: Sudalai
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D011759:Pyrrolidines; D011392:Proline; C032519:pyrrolidine