title: A phage display screening derived Peptide with affinity for the adeninyl moiety.
abstract: Phage display screening of a surface-immobilized adenine derivative led to the identification of a heptameric peptide with selectivity for adenine as demonstrated through quartz crystal microbalance (QCM) studies. The peptide demonstrated a concentration dependent affinity for an adeninyl moiety decorated surface (K D of 968 ± 53.3 μM), which highlights the power of piezoelectric sensing in the study of weak interactions.
authors.affiliation: Bioorganic & Biophysical Chemistry Laboratory, Linnæus University Centre for Biomaterials Chemistry, Linnæus University, SE-39182 Kalmar, Sweden; E-Mails: louise.elmlund@lnu.se (L.E.); pernilla.soderberg@lnu.se (P.S.); esusu@lnu.se (S.S.) ; Department of Chemistry & Biomedical Sciences, Linnæus University, SE-39182 Kalmar, Sweden.
authors.forename: Louise
authors.initials: L
authors.lastname: Elmlund
authors.affiliation: Bioorganic & Biophysical Chemistry Laboratory, Linnæus University Centre for Biomaterials Chemistry, Linnæus University, SE-39182 Kalmar, Sweden; E-Mails: louise.elmlund@lnu.se (L.E.); pernilla.soderberg@lnu.se (P.S.); esusu@lnu.se (S.S.) ; Department of Chemistry & Biomedical Sciences, Linnæus University, SE-39182 Kalmar, Sweden.
authors.forename: Pernilla
authors.initials: P
authors.lastname: Söderberg
authors.affiliation: Bioorganic & Biophysical Chemistry Laboratory, Linnæus University Centre for Biomaterials Chemistry, Linnæus University, SE-39182 Kalmar, Sweden; E-Mails: louise.elmlund@lnu.se (L.E.); pernilla.soderberg@lnu.se (P.S.); esusu@lnu.se (S.S.) ; Department of Chemistry & Biomedical Sciences, Linnæus University, SE-39182 Kalmar, Sweden.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Suriyanarayanan
authors.affiliation: Bioorganic & Biophysical Chemistry Laboratory, Linnæus University Centre for Biomaterials Chemistry, Linnæus University, SE-39182 Kalmar, Sweden; E-Mails: louise.elmlund@lnu.se (L.E.); pernilla.soderberg@lnu.se (P.S.); esusu@lnu.se (S.S.) ; Department of Chemistry & Biomedical Sciences, Linnæus University, SE-39182 Kalmar, Sweden ; Department of Chemistry-BMC, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Nicholls
keywords: QCM; adenine; molecular recognition; peptide; phage display; piezoelectric sensor