title: Association of immunoexpression of the galectins-3 and -7 with histopathological and clinical parameters in oral squamous cell carcinoma in young patients.
abstract: An increasing incidence of oral squamous cell carcinoma (OSCC) in individuals younger than 45 years has been observed in recent years. OSCC in younger patients differs in terms of biological behavior and prognosis with the disease being more aggressive than in older patients. The aim of this study was to analyze the immunohistochemical expression of galectins-3 and -7 in 32 cases of OSCC in young patients and to correlate this expression with clinical and morphological parameters. All cases of OSCC of the sample were diagnosed at oncology referral hospitals in Paraíba, Brazil, between 2002 and 2012. Clinical data were obtained from the patient records. Histological malignancy grading systems proposed by Bryne et al. (J Pathol 166:375-381, 1992) and the World Health Organization (In: Pathology and genetics of head and neck tumours: Word Health Organization classification of tumours, 2005) were used for morphological analysis. Immunohistochemistry was performed by the streptavidin-biotin technique using anti-galectin-3 and -7 antibodies. The results were analyzed statistically by the Chi-squared and Fisher exact tests (p < 0.05). Immunoexpression of galectin-3 was observed in 65.6 % of the cases analyzed, but showed no significant association with any of the variables studied (clinical staging; histological malignancy grading systems). Immunoexpression of galectin-7 was observed in 96.9 % of cases and was significantly associated with histological malignancy grading systems (p < 0.05). In conclusion, the results suggest the use of galectin-7 as marker of biological behavior and tumor progression in OSCC in young patients.
authors.affiliation: Department of Dentistry, Oral Pathology, State University of Paraiba, Juvêncio Arruda, s/n- Bodocongó, Campina Grande, PB, CEP: 58429-600, Brazil.
authors.forename: Janaina Almeida
authors.initials: JA
authors.lastname: Mesquita
authors.affiliation: Department of Dentistry, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Lélia Maria Guedes
authors.initials: LM
authors.lastname: Queiroz
authors.affiliation: Department of Dentistry, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Éricka Janine Dantas
authors.initials: ÉJ
authors.lastname: Silveira
authors.affiliation: Department of Dentistry, Oral Pathology, State University of Paraiba, Juvêncio Arruda, s/n- Bodocongó, Campina Grande, PB, CEP: 58429-600, Brazil.
authors.forename: Manuel Antônio
authors.initials: MA
authors.lastname: Gordon-Nunez
authors.affiliation: Department of Dentistry, Oral Pathology, State University of Paraiba, Juvêncio Arruda, s/n- Bodocongó, Campina Grande, PB, CEP: 58429-600, Brazil.
authors.forename: Gustavo Pina
authors.initials: GP
authors.lastname: Godoy
authors.affiliation: Department of Dentistry, Oral Pathology, State University of Paraiba, Juvêncio Arruda, s/n- Bodocongó, Campina Grande, PB, CEP: 58429-600, Brazil.
authors.forename: Cassiano Franscisco Weege
authors.initials: CF
authors.lastname: Nonaka
authors.affiliation: Department of Dentistry, Oral Pathology, State University of Paraiba, Juvêncio Arruda, s/n- Bodocongó, Campina Grande, PB, CEP: 58429-600, Brazil. pmunizalves@gmail.com.
authors.forename: Pollianna Muniz
authors.initials: PM
authors.lastname: Alves
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001798:Blood Proteins; D001938:Brazil; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D037161:Galectins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009062:Mouth Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D013223:Statistics as Topic
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; C092525:LGALS7 protein, human
keywords: Galectins; Immunohistochemistry; Oral squamous cell carcinoma; Young adult