title: Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation.
abstract: OBJECTIVE
  Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR).
  
  
  METHODS
  Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels.
  
  
  RESULTS
  Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 ± 6.3 to 48.8 ± 7.1% after surgery, p < 0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76, 6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN.
  
  
  CONCLUSIONS
  Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction.
authors.affiliation: Cardiology Clinic, Medipol University, İstanbul, Turkey.
authors.forename: H M
authors.initials: HM
authors.lastname: Gunes
authors.forename: G B
authors.initials: GB
authors.lastname: Guler
authors.forename: E
authors.initials: E
authors.lastname: Guler
authors.forename: G G
authors.initials: GG
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Hatipoglu
authors.forename: R
authors.initials: R
authors.lastname: Zehir
authors.forename: F
authors.initials: F
authors.lastname: Kizilirmak
authors.forename: O
authors.initials: O
authors.lastname: Karaca
authors.forename: A M
authors.initials: AM
authors.lastname: Esen
authors.forename: I
authors.initials: I
authors.lastname: Barutcu
authors.forename: M M
authors.initials: MM
authors.lastname: Turkmen
authors.forename: M M
authors.initials: MM
authors.lastname: Can
authors.forename: Victor L
authors.initials: VL
authors.lastname: Serebruany
mesh_terms: D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000601:surgery*; D053495:Osteopontin / Q000097:blood*; D011184:Postoperative Period; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; C506895:SPP1 protein, human; D053495:Osteopontin