title: Efficacy and safety of intraperitoneal dexmedetomidine with bupivacaine in laparoscopic colorectal cancer surgery, a randomized trial.
abstract: OBJECTIVE
  Our objective is to investigate the efficacy and safety of intraperitoneal dexmedetomidine (Dex) combined with bupivacaine in patients undergoing laparoscopic colorectal cancer surgery.
  
  
  METHODS
  Randomized double-blind study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Forty-five patients scheduled for laparoscopic colorectal cancer surgery were randomly assigned for intraperitoneal administration of 50 mL saline (control group; GI, n = 15), 50 mL bupivacaine 0.25% (125 mg; GII, n = 15), or 50 mL bupivacaine 0.25% (125 mg) +1 μg/kg Dex (GIII, n = 15). Patients were assessed during the first 24 hours postoperatively for hemodynamics, visual analogue scale (VAS), time to first request of analgesia, total analgesic consumption, shoulder pain, and side effects.
  
  
  RESULTS
  A significant reduction was observed in VAS in GIII at base line, 2, 4, and 24 hours postoperatively in comparison to GI and GII (P < 0.05). The time to first analgesic requirement was significantly prolonged in GIII (P < 0.05). The mean total consumption of rescue analgesia was significantly reduced in GIII.
  
  
  CONCLUSIONS
  We conclude that intraperitoneal administration of Dex 1 μg/kg combined with bupivacaine improves the quality and the duration of postoperative analgesia and provides an analgesic sparing effect compared to bupivacaine alone without significant adverse effects in patients undergoing laparoscopic colorectal cancer surgery.
authors.affiliation: Department of Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut, Egypt.
authors.forename: Khaled Mohamed
authors.initials: KM
authors.lastname: Fares
authors.affiliation: Department of Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut, Egypt.
authors.forename: Sahar Abd-Elbaky
authors.initials: SA
authors.lastname: Mohamed
authors.affiliation: Department of Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut, Egypt.
authors.forename: Ahmad Mohammad
authors.initials: AM
authors.lastname: Abd El-Rahman
authors.affiliation: Department of Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut, Egypt.
authors.forename: Ashraf Amin
authors.initials: AA
authors.lastname: Mohamed
authors.affiliation: Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
authors.forename: Anwar Tawfik
authors.initials: AT
authors.lastname: Amin
mesh_terms: D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects; D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007274:Injections, Intraperitoneal; D010535:Laparoscopy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D059408:Pain Management / Q000009:adverse effects / Q000379:methods; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D020927:Dexmedetomidine; D002045:Bupivacaine
keywords: Dexmedetomidine; Intraperitoneal Bupivacaine; Laparoscopic Colorectal Cancer Surgery; Postoperative Analgesia