title: Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice).
abstract: In order to elucidate the characteristics of scratching behavior in atopic dermatitis from Japanese mice (ADJM) mice, the effects of some antagonists of pruritogens on this behavior were studied. Both male and female ADJM mice showed frequent scratching behavior around the face, abdomen and back. The number of scratching behavior around the face was greater than on the abdomen and back, and scratching behavior in female mice was significantly more frequent than in male mice. Histamine H1 antagonist, chlorpheniramine, p.o., inhibited this behavior potently and dose-dependently. Histamine H1 antagonist with serotonin 5-TH(5-hydroxytryptamine)2 antagonist, cyproheptadine, also inhibited this behavior. However, NK1 antagonist, aprepitant, p.o., had no significant inhibitory effect even at a dose of 100 mg/kg, p.o., Mu antagonist, naloxone, and kappa agonist, nalfurafine, significantly inhibited this behavior at doses of 0.3 mg/kg, s.c., and 0.01 mg/kg, p.o., respectively. Histamine contents in the skin of ADJM mice were significantly higher than in BALB/c mice. These results strongly indicate that scratching behavior in ADJM mice is related with histamine H1, opioid mu and opioid kappa receptors.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University , Yasuhigashi, Asaminami-Ku, Hiroshima , Japan .
authors.forename: Tasuku
authors.initials: T
authors.lastname: Nakasone
authors.forename: Takumi
authors.initials: T
authors.lastname: Sato
authors.forename: Yoshibumi
authors.initials: Y
authors.lastname: Matsushima
authors.forename: Toshio
authors.initials: T
authors.lastname: Inoue
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000818:Animals; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002744:Chlorpheniramine / Q000494:pharmacology / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011537:Pruritus / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*
chemical_list: D000982:Antipruritics; D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine
keywords: ADJM mice; chlorpheniramine; cyproheptadine; nalfurafine; naloxone