title: Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter.
abstract: The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (K(d) = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT.
authors.affiliation: Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, Rhode Island 02881, USA. bdeboef@chm.uri.edu.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Naumiec
authors.forename: Grace
authors.initials: G
authors.lastname: Lincourt
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Clever
authors.forename: Michael A
authors.initials: MA
authors.lastname: McGregor
authors.forename: Abraham
authors.initials: A
authors.lastname: Kovoor
authors.forename: Brenton
authors.initials: B
authors.lastname: DeBoef
mesh_terms: D001665:Binding Sites; D002243:Carbolines / Q000737:chemistry*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002243:Carbolines; D050483:Dopamine Plasma Membrane Transport Proteins; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; C043232:tert-butyl beta-carboline-3-carboxylate