title: Direct N-methylation reaction using DMSO as one-carbon bridge: convenient access to heterocycle-containing β-amino ketones.
abstract: A novel oxidative C-S bond cleavage reaction of DMSO for dual C-C and C-N bond formation is described. A series of acetyl heteroarenes could be selectively converted into the corresponding β-amino ketones, which are frequently found in biologically active compounds and pharmaceuticals. DMSO acted in this reaction not only as the solvent but also as a one-carbon bridge.
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000 (P. R. China). sunk468@nenu.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Lv
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.forename: Beibei
authors.initials: B
authors.lastname: Xiao
authors.forename: Donghui
authors.initials: D
authors.lastname: Li
authors.forename: Zhonghong
authors.initials: Z
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
mesh_terms: D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds; D007659:Ketones; D004121:Dimethyl Sulfoxide
keywords: Mannich reaction; N-methylation; heterocycles; one-carbon synthon; β-amino ketones