title: Adoptive cell therapy for sarcoma.
abstract: Current therapy for sarcomas, though effective in treating local disease, is often ineffective for patients with recurrent or metastatic disease. To improve outcomes, novel approaches are needed and cell therapy has the potential to meet this need since it does not rely on the cytotoxic mechanisms of conventional therapies. The recent successes of T-cell therapies for hematological malignancies have led to renewed interest in exploring cell therapies for solid tumors such as sarcomas. In this review, we will discuss current cell therapies for sarcoma with special emphasis on genetic approaches to improve the effector function of adoptively transferred cells.
authors.affiliation: Center for Cell & Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, 1102 Bates Street, Suite 1770, Houston, TX 77030, USA.
authors.forename: Melinda
authors.initials: M
authors.lastname: Mata
authors.forename: Stephen
authors.initials: S
authors.lastname: Gottschalk
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D012509:Sarcoma / Q000276:immunology / Q000473:pathology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000637:transplantation
keywords: cancer immunotherapy; cell therapy; gene transfer; sarcoma