title: Potential for acceleration of bone formation after implant surgery by using a dietary supplement: an animal study.
abstract: Dental implant treatment is an effective modality to restore lost aesthetic and masticatory functions. However, healing after implant surgery takes at least 3-6 months. This prolonged healing period poses several difficulties for individuals with a large edentulous area and decreases their quality of life. Consequently, shortening the healing period and accelerating final prosthesis placement after surgery is very clinically important. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. To confirm whether intake of a supplement developed for osteoporosis, synthetic bone mineral (SBM), was effective in accelerating peri-implant bone formation as part of the healing process after implantation. Twenty-four 5-week-old female Wistar rats were randomly assigned to receive a standardised diet without (control group, n = 12) or with SBM (n = 12). The rats had implant surgery at 8 weeks of age under general anaesthesia. The main outcome measures were bone mineral density (BMD) and pull-out strength in the implant and femur, which were compared between the groups at 2 and 4 weeks after implantation using the Mann-Whitney U test. BMD was significantly greater in the SBM group at 2 and 4 weeks after implantation compared to the control group. Pull-out strength was significantly greater in the SBM groups at 2 and 4 weeks after implantation compared to the control group. This study demonstrated that SBM could be effective in accelerating peri-implant bone formation during the healing period after implantation.
authors.affiliation: Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Nakada
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Sakae
authors.forename: S
authors.initials: S
authors.lastname: Kimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kawai
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D015921:Dental Implants; D019587:Dietary Supplements; D005260:Female; D016348:Osseointegration / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants
keywords: animal study; bone formation; healing period; implant; supplement; synthetic bone mineral