title: Associated factors of ejection fraction in insulin-treated patients with type 2 diabetes.
abstract: OBJECTIVE
  to evaluate the relation between ejection fraction (EF), diabetes characteristics and cardiovascular risk factors.
  
  
  METHODS
  We carried out a cross-sectional study in 171 patients with insulin-treated type 2 diabetes hospitalized at the Sf. Spiridon Emergency Clinical Hospital, Iasi. All patients were evaluated for asymptomatic organ damage and cardiovascular risk factors of hypertension and diabetes metabolic control. Global ejection fraction (EF) was evaluated through 2-D echocardiography.
  
  
  CONCLUSIONS
  In the studied group the ejection fraction had significant negative correlations with the duration of the disease (p=0.007) and the presence of microalbuminuria (p=0.001). There were some differences between the categories realized by grouping the patients according to the presence of hypertension and/or previous myocardial infarction. In patients without personal history of cardiovascular disease EF was correlated only with LDLc levels. In the hypertensive patients without myocardial infarction it was correlated with diabetes duration, Hb A1e and LDLc, In those patients with both conditions, EF had significant correlations with Hb A1e and microalbuminuria.
  
  
  CONCLUSIONS
  These results emphasized that the determinants associated with heart failure in patients with type 2, insulin-treated diabetes, differ according to the presence of high blood pressure and myocardial infarction.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Medical Specialties (I). ginabotnariu66@gmail.com
authors.forename: Gina
authors.initials: G
authors.lastname: Botnariu
authors.forename: A O
authors.initials: AO
authors.lastname: Petriş
authors.forename: O R
authors.initials: OR
authors.lastname: Petriş
authors.forename: Alina D
authors.initials: AD
authors.lastname: Popa
authors.forename: Irina Iuliana
authors.initials: II
authors.lastname: Costache
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D004636:Emergency Service, Hospital; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007297:Inpatients; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013318:Stroke Volume; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin