title: Chemotherapy does not adversely impact outcome following post-incisional hernia repair with biomaterial mesh.
abstract: BACKGROUND
  Patients receiving chemotherapy are at increased risk for developing recurrent or post-incisional hernias (PIH). Biological materials are an alternative to synthetic mesh in contaminated fields. The impact of chemotherapy on biomaterial tissue ingrowth and integration has not been well studied.
  
  
  METHODS
  From 2008 to 2011 patients who underwent PIH repair with biomaterial mesh (Biodesign®) were selected. Patients were divided into two groups: those receiving chemotherapy (CT) and those not receiving chemotherapy (NCT).
  
  
  RESULTS
  Forty-five patients were identified, 28 (62%) in the NCT group and 17 (38%) in the CT group. Median follow up for NCT and CT groups were 27 and 17 months, respectively. A total of 9/45 (20%) surgical site infections (SSI) were diagnosed, with 6/28 (21%) in the NCT and 3/17 (18%) in the CT group (P = 0.53). Seroma formation was seen in 5/28 (18%) of NCT patients and 4/17 (23%) in CT group (P = 0.46). Overall hernia recurrence rate was 22%, and the rates of recurrence were similar among the CT 3/17 (18%) and NCT 7/28 (25%) groups (P = 0.42).
  
  
  CONCLUSIONS
  The use of perioperative chemotherapy did not increase the rate of wound complications following PIH repair with biologic mesh in this group of patients.
authors.affiliation: Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island.
authors.forename: Abdul
authors.initials: A
authors.lastname: Saied
authors.forename: Jenny
authors.initials: J
authors.lastname: David
authors.forename: Kim
authors.initials: K
authors.lastname: LaBarbera
authors.forename: Steven C
authors.initials: SC
authors.lastname: Katz
authors.forename: Ponnandai
authors.initials: P
authors.lastname: Somasundar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004067:Digestive System Neoplasms / Q000188:drug therapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery; D012189:Retrospective Studies; D013526:Surgical Mesh; D055815:Young Adult
keywords: biological mesh; chemotherapy; post-incisional hernia repair