title: Experimental correction of metabolic changes in mouth at long-term hypoacidity by multiprobiotic "Symbiter acidophilic".
abstract: It is known, that long decrease in gastric secretion leads to the development of hypergastrinemia, dysbiosis and to pathological changes in digestive organs. Very important there is a search of ways to correction of these undesirable consequences. Long-term usage of omeprazole leads to metabolic disorders in periodontium tissues and salivary glands, such as development of NO-ergic system disbalance and activation of free-radical oxidation, that are positively corrected by multiprobiotic of new generation "Symbiter acidophilic".
authors.forename: A M
authors.initials: AM
authors.lastname: Manko
authors.forename: K S
authors.initials: KS
authors.lastname: Neporada
authors.forename: A A
authors.initials: AA
authors.lastname: Sukhomlyn
authors.forename: J
authors.initials: J
authors.lastname: Ghasemzadeh
authors.forename: T V
authors.initials: TV
authors.lastname: Beregova
authors.forename: D S
authors.initials: DS
authors.lastname: Yankovskiy
mesh_terms: D000126:Achlorhydria / Q000139:chemically induced / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism / Q000382:microbiology; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009055:Mouth / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009853:Omeprazole / Q000009:adverse effects; D018384:Oxidative Stress / Q000187:drug effects; D010519:Periodontium / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D019936:Probiotics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D013270:Stomach / Q000187:drug effects* / Q000382:microbiology
chemical_list: D000897:Anti-Ulcer Agents; D005609:Free Radicals; D005755:Gastrins; D017127:Glycation End Products, Advanced; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D009853:Omeprazole