title: Two aspects of ASIC function: Synaptic plasticity and neuronal injury.
abstract: Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of protons and our current understanding of how ASICs contribute to various types of neuronal injury in the brain. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, China; Neuroscience Institute, Morehouse School of Medicine, Atlanta GA 30310, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA; Lab of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Lab of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Ji
authors.affiliation: Neuroscience Institute, Morehouse School of Medicine, Atlanta GA 30310, USA. Electronic address: zxiong@msm.edu.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xiong
authors.affiliation: Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA. Electronic address: zha@southalabama.edu.
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Zha
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*
chemical_list: D062565:Acid Sensing Ion Channels
keywords: ASIC; Acidosis; Neuronal injury; Proton; Synaptic plasticity