title: Electrophoretic deposition of mesoporous bioactive glass on glass-ceramic foam scaffolds for bone tissue engineering.
abstract: In this work, the coating of 3-D foam-like glass-ceramic scaffolds with a bioactive mesoporous glass (MBG) was investigated. The starting scaffolds, based on a non-commercial silicate glass, were fabricated by the polymer sponge replica technique followed by sintering; then, electrophoretic deposition (EPD) was applied to deposit a MBG layer on the scaffold struts. EPD was also compared with other techniques (dipping and direct in situ gelation) and it was shown to lead to the most promising results. The scaffold pore structure was maintained after the MBG coating by EPD, as assessed by SEM and micro-CT. In vitro bioactivity of the scaffolds was assessed by immersion in simulated body fluid and subsequent evaluation of hydroxyapatite (HA) formation. The deposition of a MBG coating can be a smart strategy to impart bioactive properties to the scaffold, allowing the formation of nano-structured HA agglomerates within 48 h from immersion, which does not occur on uncoated scaffold surfaces. The mechanical properties of the scaffold do not vary after the EPD (compressive strength ~19 MPa, fracture energy ~1.2 × 10(6) J m(-3)) and suggest the suitability of the prepared highly bioactive constructs as bone tissue engineering implants for load-bearing applications.
authors.affiliation: Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Fiorilli
authors.forename: Francesco
authors.initials: F
authors.lastname: Baino
authors.forename: Valentina
authors.initials: V
authors.lastname: Cauda
authors.forename: Marco
authors.initials: M
authors.lastname: Crepaldi
authors.forename: Chiara
authors.initials: C
authors.lastname: Vitale-Brovarone
authors.forename: Danilo
authors.initials: D
authors.lastname: Demarchi
authors.forename: Barbara
authors.initials: B
authors.lastname: Onida
mesh_terms: D001672:Biocompatible Materials; D001826:Body Fluids / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D019245:Compressive Strength; D005898:Glass; D006801:Humans; D021621:Imaging, Three-Dimensional; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D010865:Pilot Projects; D016062:Porosity; D017640:Silicates / Q000737:chemistry; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017640:Silicates; C023506:Glass ceramics