title: [Pharmacokinetics study of curcumin solid lipid nanoparticles by intravenous injection in rats].
abstract: OBJECTIVE
  To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats.
  
  
  METHODS
  Rats were administrated with (iv) curcumin solid lipid nanoparticles and curcumin solution (8.0 mg/kg), respectively. Blood samples were collected and curcumin in blood plasma was determined by HPLC. Compartmental pharmacokinetics was analyzed by DAS software.
  
  
  RESULTS
  After intravenous administration, the AUC(0-t), AUC(0-infinity) and t(1/2) of curcumin solid lipid nanoparticles were 1.50-fold, 1.63-fold and 4.08-fold higher than those of curcumin solution as (173.09 ± 44.81) μg x h/L vs. (114.83 ± 13.19) μg x h/L, (196.56 ± 35.25) μg x h/L vs. (120.66 ± 13.95) μg x h/L and (5.95 ± 2.05) h vs. (1.46 ± 0.03) h.
  
  
  CONCLUSIONS
  The curcumin solid lipid nanoparticles is eliminated more slowly. The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.
authors.affiliation: Chongqing Key Laboratory of Biochemical and Molecular Pharmacology, Chongqing Medical University, China.
authors.forename: Zi-Jun
authors.initials: ZJ
authors.lastname: Yan
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Li
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Sun
authors.forename: Xue
authors.initials: X
authors.lastname: Deng
authors.forename: Kun
authors.initials: K
authors.lastname: Wan
authors.forename: Jing-Qing
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008055:Lipids; D053758:Nanoparticles / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008055:Lipids; D003474:Curcumin