title: ECR-MAPK regulation in liver early development.
abstract: Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.
authors.affiliation: School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Collaborative Innovation Center of Processing of Agricultural Products in Hubei Province, No. 68 South Xuefu Road, Changqing Garden, Wuhan 430023, China ; Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, West No. 30 Xiaohongshan, Wuhan 430071, China.
authors.forename: Xiu-Ju
authors.identifier: 0000-0003-4962-6285
authors.initials: XJ
authors.lastname: Zhao
authors.affiliation: Xinxiang Institute for Drug Control, No. 17 Jiankang Road, Xinxiang 453000, China.
authors.forename: Hexian
authors.initials: H
authors.lastname: Zhuo
mesh_terms: D000510:Alpha-Globulins / Q000096:biosynthesis; D000818:Animals; D004622:Embryo, Mammalian; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D008099:Liver / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D020929:Mitogen-Activated Protein Kinase Kinases / Q000096:biosynthesis; D038081:Organogenesis; D051381:Rats; D059467:Transcriptome
chemical_list: D000510:Alpha-Globulins; C013803:alpha 2u globulin; D020929:Mitogen-Activated Protein Kinase Kinases