title: Adrenomedullary progenitor cells: Isolation and characterization of a multi-potent progenitor cell population.
abstract: The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues maintain stem and progenitor cells that contribute to their maintenance and adaptation. Research from the last years has proven the existence of stem and progenitor cells also in the adult adrenal medulla throughout life. These cells maintain some neural crest properties and have the potential to differentiate to the endocrine and neural lineages. In this article, we discuss the evidence for the existence of adrenomedullary multi potent progenitor cells, their isolation and characterization, their differentiation potential as well as their clinical potential in transplantation therapies but also in pathophysiology.
authors.affiliation: Division of Molecular Endocrinology, Medical Clinic III, Carl Gustav Carus University Clinic, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vukicevic
authors.affiliation: Division of Molecular Endocrinology, Medical Clinic III, Carl Gustav Carus University Clinic, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Maria Fernandez
authors.initials: MF
authors.lastname: Rubin de Celis
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Pellegata
authors.affiliation: Medical Clinic III, Carl Gustav Carus University Clinic, Technische Universität Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Bornstein
authors.affiliation: Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany; Division of Stem Cell Biology, Medical Clinic III, Carl Gustav Carus University Clinic, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Androutsellis-Theotokis
authors.affiliation: Division of Molecular Endocrinology, Medical Clinic III, Carl Gustav Carus University Clinic, Technische Universität Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01307 Dresden, Germany. Electronic address: monika.bornstein@uniklinikum-dresden.de.
authors.forename: Monika
authors.initials: M
authors.lastname: Ehrhart-Bornstein
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology* / Q000637:transplantation; D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D002469:Cell Separation / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D039902:Multipotent Stem Cells / Q000166:cytology*; D033581:Stem Cell Transplantation
keywords: ALDH; Adrenal medulla; Hes3; Progenitor cells; Stem cells; Sympathoadrenal