title: [Optimization of process of sodium aescinate lyophilized powder].
abstract: OBJECTIVE
  To determine the optimal freeze-drying process of Sodium Aescinate lyophilized powder in order to shorten the lyophilization cycle.
  
  
  METHODS
  Using the single factor experiment and L9 (3(4)) orthogonal test to optimize parameters of the herbal liquid volume and concentration, pre-freezing time, pressure, drying time and analytical temperature.
  
  
  RESULTS
  The best lyophilization process parameters were as follows: 1.0 mL herbal liquid with concentration of 10 mg/mL, phased cooling style, pre-freezing temperature at - 35 degrees C, 6.5 h; vacuum of 20 Pa;sublimation drying time of 7 h; and desorption-drying temperature of 35 degrees C for 5.5 h.
  
  
  CONCLUSIONS
  Compared with the original process conditions, the product quality is more stable and the freezing-drying cycle time is shorten of 3 h, which can provide technical reference for production process of the freeze-dried powder of sodium aescinate.
authors.affiliation: Lishizhen Institute of Natural Medicine, Wuhan, China.
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Shi
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Chen
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Huang
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Liu
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Liu
mesh_terms: D003890:Desiccation; D005612:Freeze Drying; D005615:Freezing; D011208:Powders; D012503:Saponins / Q000737:chemistry*; D013696:Temperature; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D011208:Powders; D012503:Saponins; D014315:Triterpenes; C584713:sodium aescinate