title: Gold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy.
abstract: In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase-changing molecules (1-tetradecanol, TD, T(m) 39 °C) as gatekeepers, as well as its ability to regulate the release of doxorubicin (DOX). Indeed, a nearly zero premature release is evidenced at physiological temperature (37 °C), whereas the DOX release is efficiently achieved at higher temperature not only upon external heating, but also via internal heating generated by the GNR core under near infrared irradiation. When tagged with folate moieties, GNR@MSNPs target specifically to KB cells, which are known to overexpress the folate receptors. Such a precise control over drug release, combining with the photothermal effect of GNR cores, provides promising opportunity for localized synergistic photothermal ablation and chemotherapy. Moreover, the performance in killing the targeted cancer cells is more efficient compared with the single phototherapeutic modality of GNR@MSNPs. This versatile combination of local heating, phototherapeutics, chemotherapeutics and gating components opens up the possibilities for designing multifunctional drug delivery systems.
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liege, B6a Sart-Tilman, B-4000, Liege, Belgium.|CNRS, University of Bordeaux, ICMCB, UPR 9048, F-33600, Pessac, France.
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liege, B6a Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Detrembleur
authors.affiliation: Laboratory of Mammalian Cell Culture (GIGA-R), University of Liege, B6c Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.affiliation: CNRS, University of Bordeaux, ICMCB, UPR 9048, F-33600, Pessac, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mornet
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liege, B6a Sart-Tilman, B-4000, Liege, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
authors.affiliation: CNRS, University of Bordeaux, ICMCB, UPR 9048, F-33600, Pessac, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Duguet
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D005492:Folic Acid / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D007259:Infrared Rays; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010789:Phototherapy / Q000379:methods*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D006046:Gold; D012822:Silicon Dioxide; D004317:Doxorubicin; D005492:Folic Acid
keywords: drug release; gold nanorods; mesoporous silica; near infrared; phase-changing materials