title: Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study.
abstract: OBJECTIVE
  Maintaining adequate serum levels of vitamin D may be important for sleep duration and quality; however, these associations are not well understood. We examined whether levels of serum 25(OH)D are associated with objective measures of sleep in older men.
  
  
  METHODS
  Cross-sectional study within a large cohort of community-dwelling older men, the MrOS study.
  
  
  METHODS
  Among 3,048 men age 68 years or older, we measured total serum vitamin D. Objective estimates of nightly total sleep time, sleep efficiency, and wake time after sleep onset (WASO) were obtained using wrist actigraphy worn for an average of 5 consecutive 24-h periods.
  
  
  RESULTS
  16.4% of this study population had low levels of vitamin D (< 20.3 ng/mL 25(OH)D). Lower serum vitamin D levels were associated with a higher odds of short (< 5 h) sleep duration, (odds ratio [OR] for the highest (≥ 40.06 ng/mL) versus lowest (< 20.3 ng/mL) quartile of 25(OH)D, 2.15; 95 % confidence interval (CI), 1.21-3.79; Ptrend = 0.004) as well as increased odds of actigraphy-measured sleep efficiency of less than 70% (OR, 1.45; 95% CI, 0.97-2.18; Ptrend = 0.004), after controlling for age, clinic, season, comorbidities, body mass index, and physical and cognitive function. Lower vitamin D levels were also associated with increased WASO in age-adjusted, but not multivariable adjusted models.
  
  
  CONCLUSIONS
  Among older men, low levels of total serum 25(OH)D are associated with poorer sleep including short sleep duration and lower sleep efficiency. These findings, if confirmed by others, suggest a potential role for vitamin D in maintaining healthy sleep.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Massa
authors.affiliation: California Pacific Medical Center Research Institute, San Francisco, CA, for the Osteoporotic Fractures in Men (MrOS) Study Group.
authors.forename: Katie L
authors.initials: KL
authors.lastname: Stone
authors.affiliation: California Pacific Medical Center Research Institute, San Francisco, CA, for the Osteoporotic Fractures in Men (MrOS) Study Group.
authors.forename: Esther K
authors.initials: EK
authors.lastname: Wei
authors.affiliation: California Pacific Medical Center Research Institute, San Francisco, CA, for the Osteoporotic Fractures in Men (MrOS) Study Group.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Harrison
authors.affiliation: Department of Family and Preventive Medicine, University California San Diego, La Jolla, CA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
authors.affiliation: Department of Medicine, University of California at San Diego, La Jolla, CA.|Department of Medicine, University of California at Davis School of Medicine, Sacramento, CA.
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Lane
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
authors.forename: Misti
authors.initials: M
authors.lastname: Paudel
authors.affiliation: Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Susan
authors.initials: S
authors.lastname: Redline
authors.affiliation: Departments of Psychiatry and Medicine, University of California, San Diego, CA.|Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ancoli-Israel
authors.affiliation: Oregon Clinical and Translational Research Institute and School of Medicine, Oregon Health and Science University, Portland, OR.
authors.forename: Eric
authors.initials: E
authors.lastname: Orwoll
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA.
authors.forename: Eva
authors.initials: E
authors.lastname: Schernhammer
mesh_terms: D056044:Actigraphy; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D003071:Cognition / Q000502:physiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D016017:Odds Ratio; D017286:Polysomnography; D012111:Residence Characteristics; D012890:Sleep / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D
keywords: cohort; elderly; sleep; vitamin D