title: Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
abstract: OBJECTIVE
  intravascular large B-cell lymphoma is a distinct subtype of mature B-cell neoplasms, with uncommon primary presentation in the lungs. Diagnosis could be very difficult due to the lack of detectable tumor masses and it is usually made by surgical lung biopsy or autopsy examination.
  
  
  METHODS
  two patients occurred primarily with interstitial lung disease and underwent a pulmonary biopsy using cryoprobes.
  
  
  RESULTS
  the pathological analysis of the lung biopsies revealed in both cases a conclusive diagnosis of intravascular large B-cell lymphoma with primary lung involvement and patients have been safely diagnosed using transbronchial cryobiopsy for the first time in the literature.
  
  
  CONCLUSIONS
  transbronchial cryobiopsy could be used as valid surrogate for surgical lung biopsy in lymphoprolipherative lung disorders (including intravascular lymphomas), as allows larger samples of tissue, greater  diagnostic yield, no crush artifacts and much less complications than surgical biopsy.
authors.affiliation: Department of Diseases of the Thorax Ospedale GB Morgagni, Forlì (I). venerino.poletti@gmail.com.
authors.forename: Venerino
authors.initials: V
authors.lastname: Poletti
authors.forename: Carlo
authors.initials: C
authors.lastname: Gurioli
authors.forename: Sara
authors.initials: S
authors.lastname: Piciucchi
authors.forename: Andrea
authors.initials: A
authors.lastname: Rossi
authors.forename: Claudia
authors.initials: C
authors.lastname: Ravaglia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dubini
authors.forename: Silvia
authors.initials: S
authors.lastname: Asioli
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Casoni
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy / Q000379:methods*; D001999:Bronchoscopy; D003080:Cold Temperature; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D019043:Vascular Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor