title: Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy.
abstract: Until recently, ovarian clear cell carcinoma was recognized by its unique morphology and unfavorable patient outcome primarily due to tumor chemoresistance. Recently, specific molecular characteristics of ovarian clear cell carcinoma, such as PI3CA mutation, ARID1a mutation and MET amplification, have been elucidated. In addition, an association between endometriosis and the tumor has also been a focus of research in recent years. The aim of this review is to discuss the specificity and importance of molecular changes and various intriguing points that are not solved until today. Finally, future aspects, including hopes for the development of novel therapies, are discussed.
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan k46581a@nucc.cc.nagoya-u.ac.jp.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000209:etiology / Q000235:genetics / Q000473:pathology; D004268:DNA-Binding Proteins; D004715:Endometriosis / Q000150:complications*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C112476:ARID1A protein, human; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C503859:PI3KCA protein, human; D014157:Transcription Factors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: ARID1A mutation; MET amplification; PI3CA mutation; ovarian clear cell carcinoma; targeted therapy