title: Physiological characterization of skin lesion using non-linear random forest regression model.
abstract: The current diagnostic technique for melanoma solely relies on the surface level of skin and under-skin information is neglected. Since physiological features of skin such as melanin are closely related to development of melanoma, the non-linear physiological feature extraction model based on random forest regression is proposed. The proposed model characterizes the concentration of eumelanin and pheomelanin from standard camera images or dermoscopic images, which are conventionally used for diagnosis of melanoma. For the validation, the phantom study and the separability test using clinical images were conducted and compared against the state-of-the art non-linear and linear feature extraction models. The results showed that the proposed model outperformed other comparing models in phantom and clinical experiments. Promising results show that the quantitative characterization of skin features, which is provided by the proposed method, can allow dermatologists and clinicians to make a more accurate and improved diagnosis of melanoma.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Cho
authors.forename: Shahid
authors.initials: S
authors.lastname: Haider
authors.forename: Robert
authors.initials: R
authors.lastname: Amelard
authors.forename: Alexander
authors.initials: A
authors.lastname: Wong
authors.forename: David
authors.initials: D
authors.lastname: Clausi
mesh_terms: D000465:Algorithms; D046169:Dermoscopy / Q000379:methods*; D006801:Humans; D008543:Melanins / Q000032:analysis*; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008954:Models, Biological; D019047:Phantoms, Imaging; D012044:Regression Analysis; D015203:Reproducibility of Results; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
chemical_list: D008543:Melanins; C018362:pheomelanin; C041877:eumelanin