title: Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.
abstract: Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. hyw6@mail2.sysu.edu.cn.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. chenjh96@mail.sysu.edu.cn.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Chen
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. huguping@mail.sysu.edu.cn.
authors.forename: Guping
authors.initials: G
authors.lastname: Hu
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. yujchen@mail2.sysu.edu.cn.
authors.forename: Jianchen
authors.initials: J
authors.lastname: Yu
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. zhuxun8@mail.sysu.edu.cn.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. ceslyc@mail.sysu.edu.cn.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. chenshp@mail.sysu.edu.cn.
authors.forename: Shengping
authors.initials: S
authors.lastname: Chen
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China. yuanjie@mail.sysu.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000266:history* / Q000494:pharmacology; D055808:Drug Discovery / Q000266:history* / Q000706:statistics & numerical data; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
chemical_list: D001688:Biological Products