title: ApoE type 4 allele affects cognitive function of aged population in Tianjin City, China.
abstract: Apolipoprotein E type 4 allele (ApoE∊4) is known as a risk gene for the late-onset Alzheimer's disease, and the relationship between ApoE∊4 and cognitive function of the elderly people has drawn the attention of the scientists. In this study, we investigated the relationship between ApoE∊4 and the cognitive function of the old people. A total of 156 old people were investigated, of whom 31 were ApoE∊4 carriers. The ApoE∊4 primarily influenced the global cognitive function, perceptual speed, and work memory. The results indicate that ApoE∊4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China Department of Nutrition, Tianjin Hospital, Tianjin, China.
authors.forename: Shoudan
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China.
authors.forename: Jingming
authors.initials: J
authors.lastname: Fu
authors.affiliation: College of Acupuncture and tuina, Shandong University of Traditional Chinese Medicine, Jinan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.affiliation: Department of Nutrition, Tianjin Hospital, Tianjin, China.
authors.forename: Ruomei
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China.
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China.
authors.forename: Long
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Nutrition, Tianjin Institute of Health & Environmental Medicine, Tianjin, China jyg1967@126.com.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D003071:Cognition; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D053327:Apolipoprotein E4
keywords: MMSE; apolipoprotein E type 4 allele; basic cognitive aptitude tests; cognitive function; elderly people