title: Trypsin-inspired poly(urethane-urea)s based on poly-lysine oligomer segment.
abstract: A new kind of biodegradable poly(urethane-urea)s based on poly-lysine oligomer used as the soft segment was synthesized and characterized. In vitro degradation behavior of poly (urethane-urea)s was investigated, and was assessed by (1)H NMR and mass loss. The results indicated that the peptide bonds in poly(urethane-urea)s were effectively cleaved in simulated pancreatic juice containing trypsin, while those in buffer solution without trypsin remained unaffected. The degradability was obviously improved by introducing poly-lysine oligomer into the main chain of poly(urethane-urea)s. The results of cells viability test indicated that the poly (urethane-urea)s showed a good biocompatibility on endothelial cells. The thermostability and hydrophilicity of poly(urethane-urea)s increased with increase in poly-lysine oligomer content.
authors.affiliation: a School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai 200240 , P.R. China.
authors.forename: Zhenqian
authors.initials: Z
authors.lastname: Gu
authors.forename: Fangjie
authors.initials: F
authors.lastname: Wang
authors.forename: Haoxiang
authors.initials: H
authors.lastname: Lu
authors.forename: Xinling
authors.initials: X
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D063566:Biodegradable Plastics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D011107:Polylysine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D058105:Polymerization; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D014357:Trypsin / Q000737:chemistry
chemical_list: D063566:Biodegradable Plastics; D011140:Polyurethanes; D011107:Polylysine; C044690:polyetherurethane urea; D014357:Trypsin
keywords: degradation; lysine; poly(urethane-urea)s; trypsin