title: Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis.
abstract: Interleukin (IL)-13 is a T helper 2 (Th2) cytokine that plays important roles in the pathogenesis of asthma. IL-13 induces hypersensitivity of the airways, increased mucous production, elevated serum immunoglobulin (Ig) E levels, and increased numbers of eosinophils. Many patients with IgG4-related disease have allergic backgrounds and show elevated serum IgE levels and an increase in the number of eosinophils. Upregulation of Th2/regulatory T (Treg) cytokines, including IL-13, has been detected in affected tissues of patients with IgG4-related disease. We previously reported that mast cells might be responsible for the production of the Th2/Treg cytokines IL-4, IL-10, and transforming growth factor (TGF)-β1 in IgG4-related disease. In this study, immunohistochemical analysis showed increased numbers of IL-13-positive mast cells in IgG4-related disease, which suggests that mast cells also produce IL-13 and contribute to elevation of serum IgE levels and eosinophil infiltration in IgG4-related disease.
authors.affiliation: 1] Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan [2] Department of Pathology, Kobe University Hospital, Kobe, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kyotaro
authors.initials: K
authors.lastname: Ohno
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Gion
authors.affiliation: Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan.
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Tachibana
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.affiliation: 1] Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan [2] Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
mesh_terms: D016207:Cytokines / Q000378:metabolism; D004804:Eosinophils / Q000166:cytology / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000378:metabolism*; D007150:Immunohistochemistry; D018793:Interleukin-13 / Q000378:metabolism*; D008407:Mast Cells / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012793:Sialadenitis / Q000378:metabolism / Q000473:pathology*; D013363:Submandibular Gland / Q000378:metabolism / Q000473:pathology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D018793:Interleukin-13; D007073:Immunoglobulin E; D019009:Proto-Oncogene Proteins c-kit