title: Impact of nuclear factor-κB on restoration of neuron growth and differentiation in hippocampus of degenerative brain.
abstract: The mode of action of nuclear factor-κB (NF-κB) has been extensively observed in different aspects of cell growth and proliferation. The transcription factor regulates various genes controlling inflammation and anti-inflammatory responses in different tissues. Thus, NF-κB signal gains a therapeutic prospect. The activation of NF-κB requires nuclear localization of its p65 subunit. Research also indicates an impact of phosphorylated p65 on the transcription of genes during cell growth and the immune response. Following the trends in investigations over decades, different observations suggest that NF-κB activation and phosphorylation of p65 regulate neuronal plasticity. Also, inhibition of NF-κB activation is a well-demonstrated way to attenuate inflammation. In addition to anti-inflammatory drugs, recent researches unwind a way to regulate regeneration and repair tissue damage. Thus, keeping a critical view on NF-κB signals, we propose the importance of natural or synthetic NF-κB activators for neurogenesis.
authors.affiliation: Department of Microbiology, Immunology, Saint James School of Medicine, Anguilla, British West Indies.
authors.forename: Rohit
authors.initials: R
authors.lastname: Aloor
authors.affiliation: Department of Microbiology, Immunology, Saint James School of Medicine, Anguilla, British West Indies.
authors.forename: Christine
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Mausumi
authors.initials: M
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Microbiology, Immunology, Saint James School of Medicine, Anguilla, British West Indies.|Department of Biochemistry, Saint James School of Medicine, Anguilla, British West Indies.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Dasgupta
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000473:pathology*; D055495:Neurogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016328:NF-kappa B
keywords: NF-κB; brain; dementia; hippocampus; neurogenesis; neuron