title: Aldose reductase C-106T gene polymorphism in type 2 diabetics with microangiopathy in Iranian individuals.
abstract: BACKGROUND
  Aldose reductase (AR) is the rate-limiting enzyme in the glucose metabolism, which has been implicated in the pathogenesis of diabetic microvascular complications (MVCs). Frequent C-106T polymorphism in the promoter of the AR gene may change the expression of the gene.
  
  
  OBJECTIVE
  The aim of the following study is to study the association between AR C106T genotypes and diabetic MVCs in Iranian population.
  
  
  METHODS
  We included 206 type 2 diabetic patients categorized into two groups according to the presence or absence of diabetic microangiopathy. The cases of interest were diabetic neuropathy, retinopathy and nephropathy identified during clinical and or laboratory examination. In addition, 114 age- and sex-matched individuals were selected to serve as a control group. AR genotyping was done using an amplification gel electrophoresis.
  
  
  RESULTS
  The frequency of CC genotype was specifically higher in subjects with diabetic retinopathy as compared to those without it (53.2% vs. 38.1%, P = 0.030). Patients with diabetic microangiopathy in general; however, did not differ significantly between AR genotype groups.
  
  
  CONCLUSIONS
  The C-106T polymorphism in the AR gene is likely a risk factor for development of only retinal complication of diabetes microvascular in Iranian individuals.
authors.affiliation: Bu Ali-Sina Clinical Research Development Unit, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Majid Reza Sheikh
authors.initials: MR
authors.lastname: Rezaee
authors.affiliation: Bu Ali-Sina Clinical Research Development Unit, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Ahmad Ahmadzadeh
authors.initials: AA
authors.lastname: Amiri
authors.affiliation: Molecular and Cell Biology Research Center and Medical Faculty, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Hashemi-Soteh
authors.affiliation: Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Daneshvar
authors.affiliation: Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Roghaye
authors.initials: R
authors.lastname: Emady-Jamaly
authors.affiliation: Bu Ali-Sina Clinical Research Development Unit, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Jafari
authors.affiliation: Bu Ali-Sina Clinical Research Development Unit, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran.
authors.forename: Behyar
authors.initials: B
authors.lastname: Soleimani
authors.affiliation: Department of Toxicology and Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Haghiaminjan
keywords: Aldose reductase genotypes; C-106T polymorphisms; diabetic microvascular complications