title: Effects of chronic resveratrol supplementation in military firefighters undergo a physical fitness test--a placebo-controlled, double blind study.
abstract: OBJECTIVE
  The purpose of this study was to determine the plasma metabolic response and certain indicators of oxidative stress (antioxidant system and oxidative stress biomarkers) in plasma and erythrocytes of Brazilian military firefighters supplemented or not with resveratrol (RES) for 90 days (100 mg/day). The analyses were performed before and after a typical physical fitness test (FT) used to induce oxidative stress.
  
  
  RESULTS
  In this placebo-controlled double-blinded study, we observed that RES supplementation did not present hepatic consequences compared with the placebo group following analysis of AST, ALT and GGT plasma activities. Plasma glucose and triglycerides levels were increased after the FT in firefighters supplemented with RES but were not elevated at baseline. Neither total nor cholesterol fractions were modified by RES supplementation. CK levels were increased after the firefighters performed the FT; however, no differences were determined between the placebo and RES groups. Ferric-reducing ability of plasma as well as uric acid was increased after the FT, but was not modified by RES supplementation. Plasma oxidative stress biomarkers, such as thiol content, 8-isoprostane and 8OHdG, showed no modifications, while IL-6 and TNF-α were decreased in the RES group after the FT. Among antioxidant enzyme activities determined in erythrocytes from the firefighters, only GPx activity was reduced by RES supplementation both before and after the FT.
  
  
  CONCLUSIONS
  In summary, the most pronounced effect of RES supplementation is its anti-inflammatory effect, which reduced IL-6 and TNF-α level. The FT applied to Brazilian military firefighters was not sufficient to challenge the antioxidant defense systems, and, therefore, 100mg of RES for three months did not induce significant effects.
authors.affiliation: Graduate Program in Health Sciences - CBS, Universidade Cruzeiro do Sul, São Paulo, SP 03342000, Brazil.
authors.forename: R C S
authors.initials: RC
authors.lastname: Macedo
authors.affiliation: Graduate Program in Health Sciences - CBS, Universidade Cruzeiro do Sul, São Paulo, SP 03342000, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Vieira
authors.affiliation: Ciências do Movimento Humano, Universidade Cruzeiro do Sul, Instituto de Ciências da Atividade Física e Esporte - ICAFE, Rua Galvão Bueno, 868, 13o andar, Bloco B Liberdade, São Paulo, SP 01506-000, Brazil.
authors.forename: D P
authors.initials: DP
authors.lastname: Marin
authors.affiliation: Graduate Program in Health Sciences - CBS, Universidade Cruzeiro do Sul, São Paulo, SP 03342000, Brazil; Ciências do Movimento Humano, Universidade Cruzeiro do Sul, Instituto de Ciências da Atividade Física e Esporte - ICAFE, Rua Galvão Bueno, 868, 13o andar, Bloco B Liberdade, São Paulo, SP 01506-000, Brazil. Electronic address: rosemari.otton@cruzeirodosul.edu.br.
authors.forename: R
authors.initials: R
authors.lastname: Otton
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D061388:Firefighters; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008889:Military Personnel; D018384:Oxidative Stress / Q000187:drug effects*; D010809:Physical Fitness; D015990:Placebo Effect; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015850:Interleukin-6; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D005979:Glutathione Peroxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000077185:Resveratrol
keywords: Exercise; Inflammation; Oxidative stress; Polyphenols; Resveratrol