title: Unravelling adverse reactions to NSAIDs using systems biology.
abstract: We introduce the reader to systems biology, using adverse drug reactions (ADRs), specifically hypersensitivity reactions to multiple non-steroidal anti-inflammatory drugs (NSAIDs), as a model. To disentangle the different processes that contribute to these reactions - from drug intake to the appearance of symptoms - it will be necessary to create high-throughput datasets. Just as crucial will be the use of systems biology to integrate and make sense of them. We review previous work using systems biology to study related pathologies such as asthma/allergy, and NSAID metabolism. We show examples of their application to NSAIDs-hypersensitivity using current datasets. We describe breakthroughs in high-throughput technology and speculate on their use to improve our understanding of this and other drug-induced pathologies.
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: James R
authors.initials: JR
authors.lastname: Perkins
authors.affiliation: Division of Molecular Biology and Clinical Genetics, Department of Medicine, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Sanak
authors.affiliation: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Canto
authors.affiliation: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain. Electronic address: mblancago@gmail.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanca
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain; Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Cornejo-García
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D060066:Protein Interaction Maps; D049490:Systems Biology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: NSAIDs-hypersensitivity; adverse drug reactions; functional genomics; high-throughput data; hypersensitivity drug reaction; nonsteroidal anti-inflammatory drugs (NSAIDs); systems biology