title: Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice.
abstract: OBJECTIVE
  In the present study the effects of mangiferin were tested against lung cancer-bearing mice in both the pre-initiation and post-initiation periods.
  
  
  METHODS
  Healthy male Swiss albino mice (6-8 weeks old) were used throughout the study. The animals were treated with mangiferin (100 mg/kg body weight dissolved in corn oil) two weeks before (pre-initiation) and the twelfth week after (post-initiation) the establishment of B (a) P (50 mg/kg body weight)-induced lung carcinoma.
  
  
  RESULTS
  The body weight decreased and the lung weight and levels of xenobiotic and liver marker enzymes markedly increased in the carcinogen-administered animals; and mangiferin treatment brought the values of these parameters back to the near-normal ones. The activities of lysosomal enzymes in the animals with B (a) P-induced experimental lung carcinogenesis were also assessed. In these animals there was an increase in the activities of lysosomal enzymes such as acidphosphatase, β-glucuronidase, N-acetyl glucosaminidase, and β-galactosidase.
  
  
  CONCLUSIONS
  Supplementation with mangiferin attenuated all these alterations, thus indicating its anticancer effect. Overall, the above data showed that the anticancer effect of mangiferin as a chemopreventive agent was pronounced.
authors.forename: Peramaiyan
authors.initials: P
authors.lastname: Rajendran
authors.forename: Thamaraiselvan
authors.initials: T
authors.lastname: Rengarajan
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nishigaki
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Ekambaram
authors.affiliation: Department of Medical Biochemistry, Dr. ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.
authors.forename: Dhanapal
authors.initials: D
authors.lastname: Sakthisekaran
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D001564:Benzo(a)pyrene / Q000737:chemistry; D001835:Body Weight; D063646:Carcinogenesis; D005609:Free Radicals / Q000737:chemistry; D005966:Glucuronidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy*; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D051379:Mice; D059808:Polyphenols / Q000737:chemistry; D012709:Serum Albumin / Q000378:metabolism; D044004:Xanthones / Q000627:therapeutic use*; D015262:Xenobiotics / Q000737:chemistry; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D005609:Free Radicals; D059808:Polyphenols; D012709:Serum Albumin; D044004:Xanthones; D015262:Xenobiotics; C013592:mangiferin; D001564:Benzo(a)pyrene; D000135:Acid Phosphatase; D001616:beta-Galactosidase; D005966:Glucuronidase; D000118:Acetylglucosaminidase