title: Osteoinductive calcium phosphate clay nanoparticle bone cements (CPCs) with enhanced mechanical properties.
abstract: Calcium phosphate cements (CPCs) with osteoconductive properties are limited in their applications because of their poor mechanical properties. This study investigated the additive effect of Dexamethasone-doped Halloysite Nanotubes (HNTs on the mechanical properties of CPCs. HNTs are nanosized tubes with alumino-silicate composition. Physico-chemical properties, cytocompatability and cellular functionality of the nanocomposites were assayed. Results suggest that these nanoenhanced composites have a huge potential to broaden the applications of CPCs.
authors.forename: Udayabhanu
authors.initials: U
authors.lastname: Jammalamadaka
authors.forename: Karthik
authors.initials: K
authors.lastname: Tappa
authors.forename: David
authors.initials: D
authors.lastname: Mills
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000538:Aluminum Silicates / Q000737:chemistry*; D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D001854:Bone Marrow Cells / Q000166:cytology; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D000077215:Clay; D003094:Collagen / Q000032:analysis; D003907:Dexamethasone / Q000737:chemistry / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000032:analysis; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000538:Aluminum Silicates; D001843:Bone Cements; D002130:Calcium Phosphates; D006025:Glycosaminoglycans; D003907:Dexamethasone; D003094:Collagen; C020243:calcium phosphate; D000469:Alkaline Phosphatase; D000077215:Clay