title: Neural correlates of consciousness: what we know and what we have to learn!
abstract: Consciousness is a multifaceted concept with two major components: awareness of environment and of self (i.e., the content of consciousness) and wakefulness (i.e., the level of consciousness). Medically speaking, consciousness is the state of the patient's awareness of self and environment and his responsiveness to external stimulation and inner need. A basic understanding of consciousness and its neural correlates is of major importance for all clinicians, especially those involved with patients suffering from altered states of consciousness. To this end, in this review it is shown that consciousness is dependent on the brainstem and thalamus for arousal; that basic cognition is supported by recurrent electrical activity between the cortex and the thalamus at gamma band frequencies; and that some kind of working memory must, at least fleetingly, be present for awareness to occur. New advances in neuroimaging studies are also presented in order to better understand and demonstrate the neurophysiological basis of consciousness. In particular, recent functional magnetic resonance imaging studies have offered the possibility to measure directly and non-invasively normal and severely brain damaged subjects' brain activity, whilst diffusion tensor imaging studies have allowed evaluating white matter integrity in normal subjects and patients with disorder of consciousness.
authors.affiliation: IRCCS Centro Neurolesi "Bonino Pulejo", S.S. 113, Via Palermo, Contrada Casazza, 98124, Messina, Italy, salbro77@tiscali.it.
authors.forename: Rocco Salvatore
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Alberto
authors.initials: A
authors.lastname: Cacciola
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.forename: Demetrio
authors.initials: D
authors.lastname: Milardi
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D003243:Consciousness; D006801:Humans; D009474:Neurons / Q000502:physiology