title: A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling.
abstract: A novel selenium-containing ruthenium complex Ru(phtpy)(phenSe)Cl(ClO4) (phtpy = 4-phenyl-2,2':6',2''-terpyridine, phenSe = 2-selenicimidazole[4,5-f]1,10-phenanthroline) has been synthesized and found be able to enhance radiation-induced DNA damage through superoxide overproduction, which leads to G2/M arrest and apoptosis in cancer cells by activating ROS-mediated pathways.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, China. tchentf@jnu.edu.cn tzhwj@jnu.edu.cn.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Deng
authors.forename: Lianling
authors.initials: L
authors.lastname: Yu
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Cao
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D015195:Drug Design; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012428:Ruthenium / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D012428:Ruthenium; D012643:Selenium