title: Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV Infection.
abstract: Due to the lack of therapeutic options for patients with progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS), maraviroc has generated expectations among the medical community. However, we report a patient with advanced HIV infection, who developed PML-associated IRIS and had a fatal outcome despite the addition of maraviroc to suppressive ART. Future studies are required to define the therapeutic role of maraviroc in PML-associated IRIS and differentiate individuals who may benefit from maraviroc from those who may develop neurological deterioration.
authors.affiliation: Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, 14080 México, DF, Mexico.
authors.forename: Mónica
authors.initials: M
authors.lastname: Rodríguez
authors.affiliation: Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, 14080 México, DF, Mexico.
authors.forename: Fernando Antonio
authors.initials: FA
authors.lastname: Silva-Sánchez
authors.affiliation: Servicio de Patología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 México, DF, Mexico.
authors.forename: César
authors.initials: C
authors.lastname: Luna-Rivero
authors.affiliation: Servicio Clínico 4, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 México, DF, Mexico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Vega-Barrientos
authors.affiliation: Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, 14080 México, DF, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Alvarado-de la Barrera
authors.affiliation: Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, 14080 México, DF, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Reyes-Terán