title: Mild and selective Et2Zn-catalyzed reduction of tertiary amides under hydrosilylation conditions.
abstract: Diethylzinc (Et2Zn) can be used as an efficient and chemoselective catalyst for the reduction of tertiary amides under mild reaction conditions employing cost-effective polymeric silane (PMHS) as the hydride source. Crucial for the catalytic activity was the addition of a substoichiometric amount of lithium chloride to the reaction mixture. A series of amides containing different additional functional groups were reduced to their corresponding amines, and the products were isolated in good-to-excellent yields.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory Stockholm University , SE-106 91, Stockholm, Sweden.
authors.forename: Oleksandr O
authors.initials: OO
authors.lastname: Kovalenko
authors.forename: Alexey
authors.initials: A
authors.lastname: Volkov
authors.forename: Hans
authors.initials: H
authors.lastname: Adolfsson