title: The neXtProt knowledgebase on human proteins: current status.
abstract: neXtProt (http://www.nextprot.org) is a human protein-centric knowledgebase developed at the SIB Swiss Institute of Bioinformatics. Focused solely on human proteins, neXtProt aims to provide a state of the art resource for the representation of human biology by capturing a wide range of data, precise annotations, fully traceable data provenance and a web interface which enables researchers to find and view information in a comprehensive manner. Since the introductory neXtProt publication, significant advances have been made on three main aspects: the representation of proteomics data, an extended representation of human variants and the development of an advanced search capability built around semantic technologies. These changes are presented in the current neXtProt update.
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211 pascale.gaudet@isb-sib.ch.
authors.forename: Pascale
authors.identifier: http://orcid.org/0000-0003-1813-6857
authors.initials: P
authors.lastname: Gaudet
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Pierre-André
authors.initials: PA
authors.lastname: Michel
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Monique
authors.initials: M
authors.lastname: Zahn-Zabal
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cusin
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Paula D
authors.initials: PD
authors.lastname: Duek
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Olivier
authors.initials: O
authors.lastname: Evalet
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Alain
authors.initials: A
authors.lastname: Gateau
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Anne
authors.initials: A
authors.lastname: Gleizes
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Mario
authors.initials: M
authors.lastname: Pereira
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Daniel
authors.initials: D
authors.lastname: Teixeira
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211.
authors.forename: Lydie
authors.initials: L
authors.lastname: Lane
authors.affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211.
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
mesh_terms: D002460:Cell Line; D030562:Databases, Protein; D004194:Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D020407:Internet; D011506:Proteins / Q000235:genetics*; D020543:Proteome; D040901:Proteomics
chemical_list: D011506:Proteins; D020543:Proteome