title: Parameters recorded by software of non-invasive ventilators predict COPD exacerbation: a proof-of-concept study.
abstract: OBJECTIVE
  To assess whether daily variations in three parameters recorded by non-invasive ventilation (NIV) software (respiratory rate (RR), percentage of respiratory cycles triggered by the patient (%Trigg) and NIV daily use) predict the risk of exacerbation in patients with chronic obstructive pulmonary disease (COPD) treated by home NIV.
  
  
  METHODS
  Patients completed the EXACT-Pro questionnaire daily to detect exacerbations. The 25th and 75th percentiles of each 24 h NIV parameter were calculated and updated daily. For a given day, when the value of any parameter was >75th or <25th percentile, the day was marked as 'abnormal value' ('high value' >75th, 'low value' <25th). Stratified conditional logistic regressions estimated the risk of exacerbation when ≥2 days (for RR and %Trigg) or ≥3 days (for NIV use) out of five had an 'abnormal value'.
  
  
  RESULTS
  Sixty-four patients were included. Twenty-one exacerbations were detected and medically confirmed. The risk of exacerbation was increased when RR (OR 5.6, 95% CI 1.4 to 22.4) and %Trigg (OR 4.0, 95% CI 1.1 to 14.5) were considered as 'high value' on ≥2 days out of five.
  
  
  CONCLUSIONS
  This proof-of-concept study shows that daily variations in RR and %Trigg are predictors of an exacerbation.
authors.affiliation: AGIR à dom. Association, La Tronche, France Univ Grenoble Alpes, HP2 INSERM U1042, Grenoble, France.
authors.forename: Jean-Christian
authors.initials: JC
authors.lastname: Borel
authors.affiliation: Clinique Universitaire de Physiologie et Sommeil, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France Clinique Universitaire de Pneumologie, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Pelletier
authors.affiliation: AGIR à dom. Association, La Tronche, France.
authors.forename: Nellie
authors.initials: N
authors.lastname: Taleux
authors.affiliation: Clinique Universitaire de Pneumologie, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Briault
authors.affiliation: AGIR à dom. Association, La Tronche, France Univ Grenoble Alpes, HP2 INSERM U1042, Grenoble, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Arnol
authors.affiliation: Clinique Universitaire de Pneumologie, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France INSERM 1055, Univ Grenoble Alpes, Grenoble, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pison
authors.affiliation: Univ Grenoble Alpes, HP2 INSERM U1042, Grenoble, France Clinique Universitaire de Physiologie et Sommeil, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Tamisier
authors.affiliation: INSERM U823, Centre de Recherche Institut Albert Bonniot, La Tronche, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Timsit
authors.affiliation: Univ Grenoble Alpes, HP2 INSERM U1042, Grenoble, France Clinique Universitaire de Physiologie et Sommeil, Pôle THORAX et VAISSEAUX, Hôpital A. Michallon, Grenoble, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pepin
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D063087:Noninvasive Ventilation; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000628:therapy*; D056152:Respiratory Rate; D012307:Risk Factors; D012984:Software; D011795:Surveys and Questionnaires; D012122:Ventilators, Mechanical
keywords: COPD Exacerbations; Non invasive ventilation