title: Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals.
abstract: Bisphenol A (BPA) and triclosan (TCS) were determined in urine of Belgian overweight and obese (n=151) and lean (n=43) individuals. After the first urine collection (0M), obese patients started a diet program or have undergone bariatric surgery. Hereafter, three additional urine samples from obese patients were collected after 3 (3M), 6 (6M) and 12 (12M) months. Both compounds were detected in >99% of the samples. BPA had median concentrations of 1.7 and 1.2ng/mL in obese and lean groups, respectively, while TCS had median concentrations of 1.5 and 0.9ng/mL in the obese and lean groups, respectively. The obese group had higher urinary concentrations (ng/mL) of BPA (p<0.5), while no significant differences were found for TCS between the obese and lean groups. No time trends between the different collection moments were observed. The BPA concentrations in the obese group were negatively associated with age, while no gender difference or relationship with body mass index was observed. For TCS, no relationships with gender, BMI, or age were found. The temporal variability of BPA and TCS was assessed with calculation of the intraclass correlation coefficient, Spearman rank correlation coefficients, and surrogate category analysis. We observed evidence that single spot urine samples might be predictive of exposure over a longer period of time. Dietary intakes of BPA and TCS did not differ significantly among the time points considered after obese individuals started losing weight (6 and 12months). Multiple linear regression analyses after adjusting for age and weight loss revealed negative associations between urinary TCS and serum FT4 in the 0M and 3M female obese individuals and positive associations between urinary BPA and serum TSH in the lean group.
authors.affiliation: Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.
authors.forename: Tinne
authors.initials: T
authors.lastname: Geens
authors.affiliation: Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.
authors.forename: Alin C
authors.initials: AC
authors.lastname: Dirtu
authors.affiliation: Department of Endocrinology, Diabetology and Metabolic Disease, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.
authors.forename: Eveline
authors.initials: E
authors.lastname: Dirinck
authors.affiliation: Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.
authors.forename: Govindan
authors.initials: G
authors.lastname: Malarvannan
authors.affiliation: Department of Endocrinology, Diabetology and Metabolic Disease, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Van Gaal
authors.affiliation: Department of Clinical Pharmacology, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Jorens
authors.affiliation: Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium. Electronic address: adrian.covaci@uantwerpen.be.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covaci
mesh_terms: D000328:Adult; D000367:Age Factors; D001530:Belgium; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D015992:Body Mass Index; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000652:urine*; D050177:Overweight / Q000097:blood / Q000652:urine*; D010636:Phenols / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D018709:Statistics, Nonparametric; D013851:Thinness / Q000097:blood / Q000652:urine; D013963:Thyroid Hormones / Q000378:metabolism*; D014260:Triclosan / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D015431:Weight Loss; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D013963:Thyroid Hormones; D014260:Triclosan; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Belgium; Bisphenol A; Obesity; Triclosan; Urine; Weight loss