title: Theranostic mercury: (197(m))Hg with high specific activity for imaging and therapy.
abstract: The no carrier added (NCA) radionuclide (197(m))Hg is accessible through proton induced nuclear reactions on gold. The decay properties of both simultaneous produced nuclear isomers (197m)Hg and (197)Hg like convenient half life, low energy gamma radiations for imaging, Auger and conversion electrons for therapy are combined with unique chemical and physical properties of mercury and its compounds. Gold as a monoisotopic element has a natural abundance of 100% (197)Au superseding expensive enrichment for the target material. Additionally, the high thermal conductivity of gold enables high beam current irradiations. For separation of target material a liquid-liquid extraction method was applied.
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Walther
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Preusche
authors.affiliation: Verein für Kernverfahrenstechnik und Analytik Rossendorf e.V., P.O. Box 510119, 01314 Dresden, Germany.
authors.forename: Stig
authors.initials: S
authors.lastname: Bartel
authors.affiliation: Department of Nuclear Medicine, University Hospital/Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Wunderlich
authors.affiliation: Department of Nuclear Medicine, University Hospital/Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Freudenberg
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Steinbach
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Pietzsch
keywords: (177)Lu; (197)Hg; Auger and conversion electrons; Dosimetry; Theranostics