title: Estradiol prevents Aβ 25 35-inhibited long-term potentiation induction through enhancing survival of newborn neurons in the dentate gyrus.
abstract: OBJECTIVE
  Estradiol (E2) is reported to attenuate β-amyloid (Aβ) accumulation and slow the progression of Alzheimer's disease (AD). This study explored the beneficial effect of E2 in AD using histological examination and electrophysiological recording technique in AD model mice created by intracerebroventricular injection of β-amyloid 25-35 (Aβ 25-35).
  
  
  RESULTS
  Infusion of Aβ 25-35 reduced the number of newborn neurons in the 2nd week after birth, a critical period for neurite growth, and impaired high-frequency stimulation-dependent long-term potentiation (LTP) induction in perforant path-granular synapses of hippocampal dentate gyrus (DG). Administration of E2 from the 2nd to 4th week after cell birth in Aβ 25-35-mice ameliorated the impairment of newborn neurons and LTP induction in DG. Acute application of E2 failed to increase the newborn neurons and rescue LTP induction in the DG of Aβ 25-35-mice.
  
  
  CONCLUSIONS
  The effect of E2 in Aβ 25-35-impaired LTP induction depends on its neuroprotection improvement.
authors.affiliation: a Department of Neurology, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, Shandong, China.|b Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: b Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Song
authors.affiliation: b Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Gao
authors.affiliation: c Department of Neurology, Chinese Medicine Hospital of Shandong, Chinese Medicine University, Jinan, China.
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Zhou
authors.affiliation: a Department of Neurology, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, Shandong, China.
authors.forename: Sheng-Nian
authors.initials: SN
authors.lastname: Zhou
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology*; D000089622:Doublecortin Domain Proteins; D004558:Electric Stimulation; D004958:Estradiol / Q000494:pharmacology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009479:Neuropeptides / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000633:toxicity*; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); D004958:Estradiol; D001973:Bromodeoxyuridine
keywords: estradiol (E2); hippocampus; long-term potentiation (LTP); neurogenesis; β-amyloid (Aβ)