title: [Some thoughts on the links between LC-MS/MS and therapeutic drug monitoring].
abstract: Therapeutic drug monitoring can be defined as a multiple step activity involving: (i) the measurement of a drug; (ii) the interpretation of the concentration by taking into account the concentration-effect relationship; (iii) the individual dose adjustment. For over 15 years pharmacology-toxicology departments have implemented liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) on a daily basis. This article discusses the current position of this technology in TDM routine activity.
authors.affiliation: Laboratoire de toxicologie, Faculté de pharmacie, Université de Limoges, France ; Service de pharmacologie, toxicologie et pharmacovigilance, CHU de Limoges, France ; Inserm UMR 850, Université de Limoges, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Saint-Marcoux
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002853:Chromatography, Liquid; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D013677:Medical Laboratory Science / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D007166:Immunosuppressive Agents
keywords: liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS); pharmacology and toxicology; therapeutic drug monitoring