title: Comparative anti-proliferative activity of some new 2-(arylazo)phenolate-palladium (II) complexes and cisplatin against some human cancer cell lines.
abstract: In this study, we report the synthesis of four 2-(arylazo)phenol-Pd(II) complexes and their anti-proliferative property against the human lung cancer (A549), cervical cancer (HeLa), and ovarian teratocarcinoma (PA-1) cell lines with cisplatin as the gold standard. One of the complexes, [Pd(L(2))2], induced robust apoptosis in all the chosen cells, as revealed by annexin-V-positive/propidium iodide dual staining, increased sub-G1 cell cycle population, and significant morphological changes in the treated cells. The Pd complex inflicted mitochondrial dysfunction leading to mitochondrial membrane potential loss, reactive oxygen species generation and release of cytosolic cytochrome c that activated caspase-9 and caspase-3 proteins which finally caused programmed cell death.
authors.affiliation: Department of Biochemistry, University of Calcutta , India.
authors.forename: P
authors.initials: P
authors.lastname: Banerjee
authors.forename: P
authors.initials: P
authors.lastname: Majumder
authors.forename: S
authors.initials: S
authors.lastname: Halder
authors.forename: M G B
authors.initials: MG
authors.lastname: Drew
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: S
authors.initials: S
authors.lastname: Mazumder
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D059585:G1 Phase Cell Cycle Checkpoints; D006801:Humans; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010636:Phenols; D010165:Palladium; D002945:Cisplatin
keywords: 2-(Arylazo)phenolate complexes of palladium; ROS; caspase-3; human lung cancer cell line