title: Evaluation of glutathione S-transferase T1 deletion polymorphism on type 2 diabetes mellitus risk in Zoroastrian females in Yazd, Iran.
abstract: BACKGROUND
  There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S-transferase-Theta (GSTT1) and the risk of the development of DM in Zoroastrian females in Yazd, Iran.
  
  
  METHODS
  This was a case-control study in which GSTT1 polymorphism was genotyped in 51 randomly selected DM patients and 50 randomly selected healthy controls among Zoroastrian females whose ages ranged from 40 to 70.
  
  
  RESULTS
  The frequencies of GSTT1 null genotype and GSTT1 present were 72% and 28%, respectively, in control samples, while in patients with type 2 diabetes (T2DM), the frequencies of GSTT1 null genotype and GSTT1 present were 27.5% and 72.5%, respectively. There were higher levels of triglyceride (TG), fasting blood sugar (FBS), total cholesterol (TC), low-density lipoprotein (LDL), Urea, and high-density lipoprotein (HDL) in cases of GSTT1 null genotype compared to the GSTT1 present genotype in controls.
  
  
  CONCLUSIONS
  Our results indicated that healthy subjects had a higher frequency of the GSTT1 null genotype than patients with T2DM. However, we observed no significant association between the GSTT1 null genotype and T2DM in the current study.
authors.affiliation: Medical Scientific Association, Ali-Ebne Abitaleb Faculty of Medicine, Islamic Azad University, Yazd Branch, Iran.
authors.forename: Mohammadhosain
authors.initials: M
authors.lastname: Afrand
authors.affiliation: Department of Endocrinology, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Saeedhossein
authors.initials: S
authors.lastname: Khalilzadeh
authors.affiliation: Department of Biostatistics and Epidemiology, Ali-Ebne Abitaleb Faculty of Medicine, Islamic Azad University, Yazd Branch, Iran.
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Bashardoost
authors.affiliation: Department of Medical Genetics, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Sheikhha
keywords: Ethnic group; Zoroastrian; female; genetic polymorphism; glutathione S-transferase T1; type 2 diabetes