title: Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.
abstract: Experimental data show that some angiotensin-converting enzyme (ACE) inhibitors and angiotensin AT(1) receptor antagonists that are normally used as antihypertensive drugs can exert anticonvulsant-like activity against audiogenic seizures. In the current study, a number of ACE inhibitors (captopril, enalapril, cilazapril, perindopril and zofenopril) and AT(1) antagonists (losartan, telmisartan and candesartan) were examined against pentylenetetrazole (PTZ)-induced seizures in mice. Captopril (50 mg/kg) administered intraperitoneally significantly raised the PTZ threshold (p < 0.05). The remaining drugs were not protective against PTZ-induced convulsions. The current study indicates that captopril decreases PTZ-evoked seizures in mice, which is an animal model of myoclonic convulsions.
authors.affiliation: Department of Physiopathology, Institute of Rural Health, Jaczewskiego 2, Lublin, 20-090, Poland, lukaw@mp.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Łukawski
authors.forename: Stanisław Jerzy
authors.initials: SJ
authors.lastname: Czuczwar
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000927:Anticonvulsants; D010433:Pentylenetetrazole