title: Detection of hypertensive retinopathy using vessel measurements and textural features.
abstract: Features that indicate hypertensive retinopathy have been well described in the medical literature. This paper presents a new system to automatically classify subjects with hypertensive retinopathy (HR) using digital color fundus images. Our method consists of the following steps: 1) normalization and enhancement of the image; 2) determination of regions of interest based on automatic location of the optic disc; 3) segmentation of the retinal vasculature and measurement of vessel width and tortuosity; 4) extraction of color features; 5) classification of vessel segments as arteries or veins; 6) calculation of artery-vein ratios using the six widest (major) vessels for each category; 7) calculation of mean red intensity and saturation values for all arteries; 8) calculation of amplitude-modulation frequency-modulation (AM-FM) features for entire image; and 9) classification of features into HR and non-HR using linear regression. This approach was tested on 74 digital color fundus photographs taken with TOPCON and CANON retinal cameras using leave-one out cross validation. An area under the ROC curve (AUC) of 0.84 was achieved with sensitivity and specificity of 90% and 67%, respectively.
authors.forename: Carla
authors.initials: C
authors.lastname: Agurto
authors.forename: Vinayak
authors.initials: V
authors.lastname: Joshi
authors.forename: Sheila
authors.initials: S
authors.lastname: Nemeth
authors.forename: Peter
authors.initials: P
authors.lastname: Soliz
authors.forename: Simon
authors.initials: S
authors.lastname: Barriga
mesh_terms: D001158:Arteries / Q000002:abnormalities; D016022:Case-Control Studies; D003116:Color; D019992:Databases as Topic; D006801:Humans; D058437:Hypertensive Retinopathy / Q000175:diagnosis*; D007091:Image Processing, Computer-Assisted; D007593:Joint Instability / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology; D012372:ROC Curve; D012171:Retinal Vessels / Q000473:pathology*; D012873:Skin Diseases, Genetic / Q000175:diagnosis; D054079:Vascular Malformations / Q000175:diagnosis