title: Favourable effect of Eugenol on liver histology in acute cholestasis in rats after bile duct ligation.
abstract: BACKGROUND
  Eugenol an essential oil found in clove was previously shown to have some anti-inflammatory properties. It also was shown to be linked to hepatoprotective effect. In this regard, we aimed to reveal the effect of eugenol on cholestatic liver disease.
  
  
  METHODS
  Cholestatic liver disease model was established in 20 rats via bile duct ligation. Eugenol was administered and cytokine levels and liver histology after sacrifice were evaluated.
  
  
  RESULTS
  Biliary ductular proliferation and neutropil infiltration were lower in eugenol-administered rats.
  
  
  CONCLUSIONS
  Eugenol has a promising effect on liver histology in cholestatic liver disease (Tab. 1, Fig. 2, Ref. 16).
authors.forename: M
authors.initials: M
authors.lastname: Sarikaya
authors.forename: L
authors.initials: L
authors.lastname: Filik
authors.forename: B
authors.initials: B
authors.lastname: Ergul
authors.forename: Z
authors.initials: Z
authors.lastname: Dogan
authors.forename: M
authors.initials: M
authors.lastname: Alparslan Gonultas
authors.forename: S
authors.initials: S
authors.lastname: Hucumenoglu
authors.forename: M
authors.initials: M
authors.lastname: Can
authors.forename: M E
authors.initials: ME
authors.lastname: Duymus
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000601:surgery; D002779:Cholestasis / Q000188:drug therapy* / Q000209:etiology*; D004195:Disease Models, Animal; D005054:Eugenol / Q000494:pharmacology*; D008026:Ligation; D008099:Liver / Q000166:cytology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005054:Eugenol