title: Tubulins - the target for anticancer therapy.
abstract: Tubulin has picked up great focus as a major target in drug discovery and consequently, tubulin inhibitors have pulling in a considerable attention as anticancer agents. Numerable naturally occurring agents have focused on tubulin system act as an imperative target of cancer chemotherapy. Substantial number of tubulin inhibitors has been discovered so far and these agents are classified as indicated by their interaction. They are colchicine site binder, vinca- alkaloid related drugs and those interacting with the Taxol binding site and functioning as stabilising agents. We review the recent advances in the advancement of tubulin interfering agents and will render the current trend in the improvement of tubulin inhibitors as anticancer agents.
authors.forename: N G
authors.initials: NG
authors.lastname: Vindya
authors.forename: Nishant
authors.initials: N
authors.lastname: Sharma
authors.forename: Mukesh
authors.initials: M
authors.lastname: Yadav
authors.affiliation: School of Advanced Sciences, VIT University, Vellore, 632014, India. ethukr@gmail.com.
authors.forename: K R
authors.initials: KR
authors.lastname: Ethiraj
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000627:therapeutic use; D001665:Binding Sites; D047188:Chalcones / Q000737:chemistry / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017239:Paclitaxel / Q000737:chemistry / Q000627:therapeutic use; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*; D050257:Tubulin Modulators / Q000737:chemistry* / Q000627:therapeutic use; D014748:Vinca Alkaloids / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D018942:Macrolides; D014404:Tubulin; D050257:Tubulin Modulators; D014748:Vinca Alkaloids; D017239:Paclitaxel; D003078:Colchicine