title: Participation of signaling cascades in the regulation of erythropoiesis under conditions of cytostatic treatment.
abstract: We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, laarmi@yandex.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Burmina
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D054697:Cytostatic Agents / Q000627:therapeutic use*; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D054697:Cytostatic Agents; D016328:NF-kappa B; D004921:Erythropoietin; D048051:p38 Mitogen-Activated Protein Kinases; D005472:Fluorouracil