title: [Is there a relationship between gouty arthritis and Mediterranean fever gene mutations?].
abstract: OBJECTIVE
  Gouty arthritis and familial Mediterranean fever (FMF) share some clinical and pathological features such as being classified as auto inflammatory disease, association with inflammasome, short-lived intermittent arthritis, and good response to colchicine and anti-interleukin-1 treatments. As Mediterranean fever (MEFV) gene is the causative factor of FMF, we aimed to investigate the prevalence of MEFV gene mutations and their effect on disease manifestations in Turkish gouty arthritis patients.
  
  
  METHODS
  Ninety-seven patients diagnosed with primary gouty arthritis (93M and 4 F, 54 [37-84] years) and 100 healthy controls (94M and 6 F, 57 [37-86] years) included in the study. All subjects were genotyped for the MEFV variations. Number of gout attacks, diuretic use, and history of nephrolithiasis and presence of tophus were also recorded.
  
  
  RESULTS
  The carriage rate of MEFV mutations for patients and controls were 22.7% (n=22) and 24% (n=24) respectively. The comparison of the patient and control groups yielded no significant difference in terms of the MEFV mutations carriage rate (p=0.87). The allelic frequencies of the MEFV mutations in patients were 11.9% (n=23) and 14% (n=28) in controls (p=0.55). The presence of MEFV variants did not show any association with clinical features of gouty arthritis. The subgroup analysis of patients revealed that gouty arthritis patients with mutations had similar frequencies of tophus, history of nephrolithiasis and podogra compared to the ones without mutations (p>0.05).
  
  
  CONCLUSIONS
  This study does not provide support for a major role of MEFV mutations in Turkish gouty arthritis patients.
authors.affiliation: Departamento de Reumatologia, Escola de Medicina, Dokuz Eylul University, Izmir, Turquia; Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia. Electronic address: ismailsari35@gmail.com.
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Ismail
authors.initials: I
authors.lastname: Simsek
authors.affiliation: Departamento de Genética Médica, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tunca
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia; Departamento de Reumatologia, Escola de Medicina, Gaziantep University, Gaziantep, Turquia.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kisacik
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Hakan
authors.initials: H
authors.lastname: Erdem
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Salih
authors.initials: S
authors.lastname: Pay
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Hasan Fatih
authors.initials: HF
authors.lastname: Cay
authors.affiliation: Departamento de Genética Médica, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Davut
authors.initials: D
authors.lastname: Gul
authors.affiliation: Departamento de Reumatologia, Gulhane Military Medical Academy, Ankara, Turquia.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dinc
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015210:Arthritis, Gouty / Q000175:diagnosis / Q000235:genetics*; D003430:Cross-Sectional Studies; D010505:Familial Mediterranean Fever / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation
keywords: Artrite gotosa; Familial Mediterranean fever; Febre familiar do Mediterrâneo; Gouty arthritis; MEFV protein; Proteína MEFV