title: Nickel-catalyzed alkynylation of anisoles via C-O bond cleavage.
abstract: A new cross-coupling reaction has been developed for the introduction of an alkyne moiety to an anisole derivative through C-O bond activation using an NHC ligand. This method has been used for direct alkynylation of a broad range of anisole derivatives and provided rapid access to compounds with potential applications in biological and materials science.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tobisu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahira
authors.forename: Akimichi
authors.initials: A
authors.lastname: Ohtsuki
authors.forename: Naoto
authors.initials: N
authors.lastname: Chatani