title: Cyclosporine for the treatment of HLTV-1-induced HAM/TSP: an experience from a case report.
abstract: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern.We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who started with a gait disturbance at Vall d'Hebron University Hospital (Barcelona) from August 2012 to October 2013. After 62 weeks of treatment, clinical improvement was observed and proviral load diminished. No safety concerns were observed.Cyclosporine seems to be effective in new-onset HAM/TSP or in chronic HAM/TSP that develops a relapse. However, the duration and safety profile of this steroid-sparing therapy remain unknown and should be further investigated.
authors.affiliation: From the Infectious Diseases Department (AS-M, FS, IM), PROSICS (International Health Program of the Catalan Health Institute), Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain; and Microbiology Department (EC), Vall d'Hebron Universitary Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Adrián
authors.initials: A
authors.lastname: Sánchez-Montalvá
authors.forename: Fernando
authors.initials: F
authors.lastname: Salvador
authors.forename: Estrella
authors.initials: E
authors.lastname: Caballero
authors.forename: Israel
authors.initials: I
authors.lastname: Molina
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015493:Paraparesis, Tropical Spastic / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine