title: The bank of biological samples representing individuals exposed to long-term ionizing radiation at various doses.
abstract: Collection and storage of biological specimens in biobanks aims to obtain and preserve samples of different kinds for biological and medical studies. Here we present a description of the Bank of Biological Materials (BBM) housed by the Seversk Biophysical Research Centre (SBRC; Seversk, Russia). The main goal of maintaining the BBM is to collect and store biological samples suitable for genetic studies of people exposed to long-term ionizing radiation. Currently, the collection includes 19,194 biological specimens obtained from 8105 donors, of whom 42.3% are diagnosed with malignant neoplasms, 28.7% are healthy residents of the city of Seversk, 18.8% are healthy employees of the Siberian Group of Chemical Enterprises (SGCE), and 10.2% are patients diagnosed with acute myocardial infarction. The donors were enrolled using the Regional Medical and Dosimetric Register database created by the SBRC. For each donor, DNA specimens were extracted from peripheral blood and tissues and cell suspensions for cytogenetic analysis were prepared routinely. The BBM's unique collection is suitable primarily for studies of individual radiosensitivity of humans (IRH), and genetic aspects of the pathophysiology of common human diseases, especially in populations exposed to long-term low-dose ionizing radiation.
authors.affiliation: 1 Seversk Biophysical Research Center of the Russian Federal Medical and Biological Agency , Seversk, Tomsk Region, Russia .
authors.forename: Ravil M
authors.initials: RM
authors.lastname: Takhauov
authors.forename: Andrey B
authors.initials: AB
authors.lastname: Karpov
authors.forename: Elena N
authors.initials: EN
authors.lastname: Albach
authors.forename: Maria V
authors.initials: MV
authors.lastname: Khalyuzova
authors.forename: Maxim B
authors.initials: MB
authors.lastname: Freidin
authors.forename: Nicolai V
authors.initials: NV
authors.lastname: Litviakov
authors.forename: Aleksey E
authors.initials: AE
authors.lastname: Sazonov
authors.forename: Daria S
authors.initials: DS
authors.lastname: Isubakova
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Bolshakov
authors.forename: Stanislav A
authors.initials: SA
authors.lastname: Mezheritskiy
authors.forename: Elena B
authors.initials: EB
authors.lastname: Mironova
authors.forename: Julia V
authors.initials: JV
authors.lastname: Semenova
authors.forename: Gennadiy B
authors.initials: GB
authors.lastname: Nekrasov
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Izosimov
authors.forename: Aleksey A
authors.initials: AA
authors.lastname: Gagarin
authors.forename: Roman V
authors.initials: RV
authors.lastname: Brendakov
authors.forename: Dmitriy E
authors.initials: DE
authors.lastname: Maksimov
authors.forename: Yuriy D
authors.initials: YD
authors.lastname: Ermolaev
mesh_terms: D018070:Biological Specimen Banks / Q000458:organization & administration; D004247:DNA / Q000528:radiation effects*; D064368:Healthy Volunteers; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D016273:Occupational Exposure; D011839:Radiation, Ionizing; D012307:Risk Factors; D012426:Russia; D013048:Specimen Handling / Q000379:methods*
chemical_list: D004247:DNA