title: [Brain abscess caused by Haemophilus influenzae type E in a pediatric patient suffering from Apert syndrome].
abstract: We report a case of a brain abscess caused by Haemophilus influenzae type e in a 12 year-old patient suffering from Apert syndrome. Apert syndrome is characterized by the premature closure of cranial sutures. In 2010 the patient suffered head trauma in the frontal area with cranial fracture and a cerebrospinal fluid fistula. In February 2013 he was admitted to hospital with fever, vomiting and generalized tonic-clonic seizure with deteriorating mental status/progressive sensory impairment. The computerized axial tomographic scan showed a right frontal lesion, perilesional edema, mild ventricular dilatation and pansinusitis. A brain abscess was diagnosed and drained. The clinical sample was then cultured. A gram negative coccobacillus was isolated and identified as Haemophilus influenzae serotype e. Empirical treatment was started with meropenem (120 mg/kg/day) and vancomycin (60 mg/kg/day), which was later switched to ceftriaxone (100 mg/kg/day) and metronidazole (500 mg/8 h) after culture results arrived. The patient was discharged in good clinical condition.
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: adela_isasmendi@hotmail.com.
authors.forename: Adela M
authors.initials: AM
authors.lastname: Isasmendi
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: José L
authors.initials: JL
authors.lastname: Pinheiro
authors.affiliation: Servicio de Control Epidemiológico e Infectología. Hospital de Pediatría Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Natalia García
authors.initials: NG
authors.lastname: Escudé
authors.affiliation: Servicio Bacteriología Clínica, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Efrón
authors.affiliation: Servicio Bacteriología Clínica, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: María A
authors.initials: MA
authors.lastname: Moscoloni
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Hernández
mesh_terms: D000168:Acrocephalosyndactylia; D001922:Brain Abscess / Q000382:microbiology*; D002648:Child; D006192:Haemophilus Infections / Q000150:complications*; D006193:Haemophilus influenzae; D006801:Humans; D008297:Male
keywords: Absceso cerebral; Apert syndrome; Brain abscess; Haemophilus influenzae; Síndrome de Aper