title: Microwave-promoted tin-free iminyl radical cyclization with TEMPO trapping: a practical synthesis of 2-acylpyrroles.
abstract: Microwave-promoted iminyl radical cyclizations can be terminated by trapping with TEMPO, affording functionalized adducts. The use of alkynes as radical acceptors delivers a range of 2-acylpyrroles in good yields. Toxic and hazardous reagents, which are frequently employed in radical reactions, are not required. The O-phenyl oxime ether substrates are constructed in a single step from readily available ketones.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
authors.forename: Ankur
authors.initials: A
authors.lastname: Jalan
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Kubosumi
authors.forename: Steven L
authors.initials: SL
authors.lastname: Castle