title: A lymphocyte-mediated cause of secondary PAP.
abstract: In this issue of Blood, Iriguchi et al report that T-lymphocyte–restricted overexpression of T-bet causes a maturational arrest in mononuclear phagocyte lineage cells and severe secondary pulmonary alveolar proteinosis (PAP).
authors.affiliation: CINCINNATI CHILDREN'S HOSPITAL; UNIVERSITY OF CINCINNATI.
authors.forename: Bruce C
authors.identifier: http://orcid.org/0000-0003-2817-6254
authors.initials: BC
authors.lastname: Trapnell
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*; D011649:Pulmonary Alveolar Proteinosis / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000096:biosynthesis*; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor