title: Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.
abstract: Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013843:Thiazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D013843:Thiazines; D013844:Thiazoles; C000598673:thiasporine A; C000598674:thiasporine B; C000598675:thiasporine C