title: A protein restriction-dependent sulfur code for longevity.
abstract: The restriction of proteins has recently emerged as the most important factor for the beneficial effects of calorie restriction. Hine et al. now provide strong evidence for the role of the hydrogen sulfide (H2S) gas in the protective effects of calorie and protein restriction against ischemia/reperfusion injury (IRI) but also implicate H2S in longevity extension in model organisms.
authors.affiliation: Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Shim
authors.affiliation: Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; Longevity Institute, Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
authors.forename: Valter D
authors.initials: VD
authors.lastname: Longo
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008297:Male
chemical_list: D006862:Hydrogen Sulfide