title: Detection of hand, foot and mouth disease in the yucatan peninsula of Mexico.
abstract: We report a case of hand, foot and mouth disease (HFMD) in a 5-year-old male from Merida City in the Yucatan Peninsula of Mexico. A clinical and physical examination revealed that the patient had symptoms typical of HFMD, including fever, fatigue, odynophagia, throat edema, hyperemia, lesions on the hands and feet, and blisters in the oral cavity. The patient fully recovered after a convalescence period of almost three weeks. Reverse transcription-polymerase chain reaction and nucleotide sequencing revealed that the etiological agent was enterovirus 71 (EV71). The sequence has greatest (90.4%) nucleotide identity to the corresponding regions of EV71 isolates from the Netherlands and Singapore. Although HFMD is presumably common in Mexico, surprisingly there are no data in the PubMed database to support this. This case report provides the first peer-reviewed evidence of HFMD in Mexico.
authors.affiliation: Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Machain-Williams
authors.affiliation: Private Practice , Mérida, Yucatán, México.
authors.forename: Alma R
authors.initials: AR
authors.lastname: Dzul-Rosado
authors.affiliation: Laboratorio de Enfermedades Emergentes y Re-emergentes, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , Mérida, Yucatán, México.
authors.forename: Aarón B
authors.initials: AB
authors.lastname: Yeh-Gorocica
authors.affiliation: Laboratorio de Enfermedades Emergentes y Re-emergentes, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , Mérida, Yucatán, México.
authors.forename: Katia G
authors.initials: KG
authors.lastname: Rodriguez-Ruz
authors.affiliation: Laboratorio de Enfermedades Emergentes y Re-emergentes, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , Mérida, Yucatán, México.
authors.forename: Henry
authors.initials: H
authors.lastname: Noh-Pech
authors.affiliation: Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , México.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Talavera-Aguilar
authors.affiliation: Laboratorio de Inmunología Celular e Inmunopatogénesis, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional , Mexico.
authors.forename: Ma Isabel
authors.initials: MI
authors.lastname: Salazar
authors.affiliation: Laboratorio de Inmunología Celular e Inmunopatogénesis, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional , Mexico.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Castro-Mussot
authors.affiliation: Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , México.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Reyes-Solis
authors.affiliation: Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , México.
authors.forename: Julián E
authors.initials: JE
authors.lastname: Garcia-Rejon
authors.affiliation: Laboratorio de Enfermedades Emergentes y Re-emergentes, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán , Mérida, Yucatán, México.
authors.forename: Fernando I
authors.initials: FI
authors.lastname: Puerto-Manzano
authors.affiliation: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA, USA.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Blitvich
keywords: Mexico; case report; enterovirus; foot and mouth disease; hand