title: Effect of supplementation of water-soluble vitamins on oxidative stress and blood pressure in prehypertensives.
abstract: The objective of the study was to evaluate the effect of water-soluble vitamins on oxidative stress and blood pressure in prehypertensives. Sixty prehypertensives were recruited and randomized into 2 groups of 30 each. One group received water-soluble vitamins and the other placebo for 4 months. Further increase in blood pressure was not observed in the vitamin group which increased significantly in the placebo group at the end of 4 months. Malonedialdehyde and protein carbonylation were reduced during the course of treatment with vitamins whereas in the placebo group there was an increase in the level of malondialdehyde. In conclusion, supplementation of water-soluble vitamins in prehypertension reduces oxidative stress and its progression to hypertension.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India and.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Talikoti
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: Abdoul
authors.initials: A
authors.lastname: Hamide
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D012995:Solubility; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*; D014867:Water
chemical_list: D000975:Antioxidants; D014815:Vitamins; D014867:Water
keywords: Oxidative stress; prehypertension; water-soluble vitamins