title: Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
abstract: Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.
authors.affiliation: Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Mali
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Department of Radiology, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Radiology, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Jiangyang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
authors.affiliation: Sirtris, a GSK company Collegeville, Pennsylvania, 19426.
authors.forename: James L
authors.initials: JL
authors.lastname: Ellis
authors.affiliation: Sirtris, a GSK company Collegeville, Pennsylvania, 19426.
authors.forename: George P
authors.initials: GP
authors.lastname: Vlasuk
authors.affiliation: Sirtris, a GSK company Collegeville, Pennsylvania, 19426.
authors.forename: Harvey
authors.initials: H
authors.lastname: Fries
authors.affiliation: Sirtris, a GSK company Collegeville, Pennsylvania, 19426.
authors.forename: Vipin
authors.initials: V
authors.lastname: Suri
authors.affiliation: Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287 ; Department of Neuroscience, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287 ; Program in Cellular and Molecular Medicine, School of Medicine, Johns Hopkins University Baltimore, Maryland, 21287.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Duan