title: Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: a Systematic Review and Meta-analysis.
abstract: Previous studies suggested a possible association between serum uric acid levels and peripheral neuropathy in patients with type 2 diabetes, but no definite evidence was available. A systematic review and meta-analysis of relevant studies were performed to comprehensively estimate the association. Pubmed, Web of Science, Embase, and China Biology Medicine (CBM) databases were searched for eligible studies. Study-specific data were combined using random-effect or fixed-effect models of meta-analysis according to between-study heterogeneity. Twelve studies were finally included into the meta-analysis, which involved a total of 1388 type 2 diabetic patients with peripheral neuropathy and 4746 patients without peripheral neuropathy. Meta-analysis showed that there were obvious increased serum uric acid levels in diabetic patients with peripheral neuropathy (weighted mean difference [WMD] = 50.03 μmol/L, 95% confidence interval [95%CI] 22.14-77.93, P = 0.0004). Hyperuricemia was also significantly associated with increased risk of peripheral neuropathy in patients with type 2 diabetes (risk ratio [RR] = 2.83, 95%CI 2.13-3.76, P < 0.00001). Meta-analysis of two studies with adjusted risk estimates showed that hyperuricemia was independently associated with increased risk of peripheral neuropathy in type 2 diabetic patients (RR = 1.95, 95%CI 1.23-3.11, P = 0.005). Type 2 diabetic patients with peripheral neuropathy have obvious increased serum uric acid levels, and hyperuricemia is associated with increased risk of peripheral neuropathy. Further prospective cohort studies are needed to validate the impact of serum uric acid levels on peripheral neuropathy risk.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Rheumatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Che
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of QingdaoUniversity, Qingdao, 266003, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China. nlwang@126.com.
authors.forename: Yangang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China. robin.wangqy@gmail.com.|Essencemed Clinic, Weifang, 261000, China. robin.wangqy@gmail.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003929:Diabetic Neuropathies / Q000097:blood* / Q000150:complications; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications; D017594:Publication Bias; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Diabetic peripheral neuropathy; Hyperuricemia; Uric acid