title: Mercapto-ordered carbohydrate-derived porous carbon electrode as a novel electrochemical sensor for simple and sensitive ultra-trace detection of omeprazole in biological samples.
abstract: We are introducing mercapto-mesoporous carbon modified carbon paste electrode (mercapto-MP-C-CPE) as a new sensor for trace determination of omeprazole (OM) in biological samples. The synthesized modifier was characterized by thermogravimetry analysis (TGA), differential thermal analysis (DTA), transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), elemental analysis (CHN) and N2 adsorption surface area measurement (BET). The electrochemical response characteristic of the modified-CPE toward OM was investigated by cyclic and differential pulse voltammetry (CV and DPV). The proposed sensor displayed a good electrooxidation response to the OM, its linear range is 0.25nM to 25μM with a detection limit of 0.04nM under the optimized conditions. The prepared modified electrode shows several advantages such as high sensitivity, long-time stability, wide linear range, ease of preparation and regeneration of the electrode surface by simple polishing and excellent reproducibility.
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran; Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Kalate Bojdi
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Behbahani
authors.affiliation: Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, Tehran, Iran.
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Mashhadizadeh
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Bagheri
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran. Electronic address: ss-hosseiny@sbu.ac.ir.
authors.forename: Saied Saeed
authors.initials: SS
authors.lastname: Hosseiny Davarani
authors.affiliation: Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Farahani
mesh_terms: D002244:Carbon / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D046529:Microscopy, Electron, Transmission; D009853:Omeprazole / Q000032:analysis* / Q000097:blood / Q000652:urine; D016062:Porosity; D015203:Reproducibility of Results; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D002244:Carbon; D009853:Omeprazole
keywords: Biological samples; Electrochemical sensor; Mesoporous carbon; Omeprazole