title: Oculomotor performance in children with high-functioning Autism Spectrum Disorders.
abstract: Sensorimotor issues are of increasing focus in the assessment and treatment of Autism Spectrum Disorders (ASD). The oculomotor system is a sensorimotor network that can provide insights into functional neurobiology and has well-established methodologies for investigation. In this study, we assessed oculomotor performance among children with high functioning ASD and typically developing children, ages 6-12 years. Children with ASD exhibited greater horizontal saccade latency and greater phase lag during vertical smooth pursuit. Saccades and smooth pursuit are mediated by spatially distant brain regions and the long-fiber tracts connecting them, many of which are implicated in ASD. Training paradigms for oculomotor deficits have shown positive outcomes in other clinical populations, and deficits described here may provide useful targets for interventions.
authors.affiliation: Department of Psychology, University of Florida, 945 Center Drive, P.O. Box 112250, Gainesville, FL 32611, United States. Electronic address: bwilkes@ufl.edu.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Wilkes
authors.affiliation: Department of Psychology, University of Florida, 945 Center Drive, P.O. Box 112250, Gainesville, FL 32611, United States. Electronic address: bleser@ufl.edu.
authors.forename: Tana B
authors.initials: TB
authors.lastname: Carson
authors.affiliation: Department of Psychology, University of Florida, 945 Center Drive, P.O. Box 112250, Gainesville, FL 32611, United States. Electronic address: kunalppat@ufl.edu.
authors.forename: Kunal P
authors.initials: KP
authors.lastname: Patel
authors.affiliation: Department of Psychiatry, University of Florida, 1149 Newell Drive, P.O. Box 100256, Gainesville, FL 32611, United States. Electronic address: marklewis@ufl.edu.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Lewis
authors.affiliation: Department of Psychology, University of Florida, 945 Center Drive, P.O. Box 112250, Gainesville, FL 32611, United States. Electronic address: kdwhite@ufl.edu.
authors.forename: Keith D
authors.initials: KD
authors.lastname: White
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D053483:Eye Movement Measurements; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D011698:Pursuit, Smooth / Q000502:physiology*; D012438:Saccades / Q000502:physiology*
keywords: ASD; Autism; Oculomotor; Saccade; Smooth pursuit