title: A nanostructured conductive hydrogels-based biosensor platform for human metabolite detection.
abstract: The development of a scalable, low-cost, and versatile biosensor platform for the sensitive and rapid detection of human metabolites is of great interest for healthcare, pharmaceuticals, and medical science. On the basis of hierarchically nanostructured conducting polymer hydrogels, we designed a flexible biosensor platform that can detect various human metabolites, such as uric acid, cholesterol, and triglycerides. Owing to the unique features of conducting polymer hydrogels, such as high permeability to biosubstrates and rapid electron transfer, our biosensors demonstrate excellent sensing performance with a wide linear range (uric acid, 0.07-1 mM; cholesterol, 0.3-9 mM, and triglycerides, 0.2-5 mM), high sensitivity, low sensing limit, and rapid response time (∼3 s). Given the facile and scalable processability of hydrogels, the proposed conductive hydrogels-based biosensor platform shows great promise as a low-cost sensor kit for healthcare monitoring, clinical diagnostics, and biomedical devices.
authors.affiliation: Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University , Nanjing 210093, China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Li
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Wang
authors.forename: Lijia
authors.initials: L
authors.lastname: Pan
authors.forename: Ye
authors.initials: Y
authors.lastname: Shi
authors.forename: Wen
authors.initials: W
authors.lastname: Cheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Guihua
authors.initials: G
authors.lastname: Yu
mesh_terms: D015374:Biosensing Techniques; D002784:Cholesterol / Q000032:analysis; D006801:Humans; D020100:Hydrogels; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000032:analysis
chemical_list: D020100:Hydrogels; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol
keywords: Conductive polymers; biosensor; cholesterol; human metabolite; hydrogel; triglyceride; uric acid