title: FCRL3 gene polymorphisms confer autoimmunity risk for allergic rhinitis in a Chinese Han population.
abstract: BACKGROUND
  Heredity and environmental exposures may contribute to a predisposition to allergic rhinitis (AR). Autoimmunity may also involve into this pathologic process. FCRL3 (Fc receptor-like 3 gene), a novel immunoregulatory gene, has recently been reported to play a role in autoimmune diseases.
  
  
  OBJECTIVE
  This study was performed to evaluate the potential association of FCRL3 polymorphisms with AR in a Chinese Han population.
  
  
  METHODS
  Five single-nucleotide polymorphisms of FCRL3, rs945635, rs3761959, rs7522061, rs10489678 and rs7528684 were genotyped in 540 AR patients and 600 healthy controls using a PCR-restriction fragment length polymorphism assay. Allele, genotype and haplotype frequencies were compared between patients and controls using the χ2 test. The online software platform SHEsis was used to analyze their haplotypes.
  
  
  RESULTS
  This study identified three strong risk SNPs rs7528684, rs10489678, rs7522061 and one weak risk SNP rs945635 of FCRL3 in Chinese Han AR patients. For rs7528684, a significantly increased prevalence of the AA genotype and A allele in AR patients was recorded. The frequency of the GG genotype and G allele of rs10489678 was markedly higher in AR patients than those in controls. For rs7522061, a higher frequency of the TT genotype, and a lower frequency of the CT genotype were found in AR patients. Concerning rs945635, a lower frequency of the CC genotype, and a higher frequency of G allele were observed in AR patients. According to the analysis of the three strong positive SNPs, the haplotype of AGT increased significantly in AR cases (AR = 38.8%, Controls = 24.3%, P = 8.29 × 10(-14), OR [95% CI] 1.978 [1.652~2.368]).
  
  
  CONCLUSIONS
  This study found a significant association between the SNPs in FCRL3 gene and AR in Chinese Han patients. The results suggest these gene polymorphisms might be the autoimmunity risk for AR.
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Hong
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ke
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, PR China.
authors.forename: Hou-Yong
authors.initials: HY
authors.lastname: Kang
mesh_terms: D044466:Asian People / Q000235:genetics; D015551:Autoimmunity / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D065631:Rhinitis, Allergic / Q000208:ethnology / Q000235:genetics*
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic