title: Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by 99mTc-ECD SPECT imaging.
abstract: OBJECTIVE
  This study aimed to observe the effect of local mild hypothermia on regional cerebral blood flow (rCBF) after acute intracerebral hemorrhage (ICH) and to evaluate its relation to clinical outcome in patients with ICH.
  
  
  METHODS
  36 CT proven ICH patients with Glasgow coma scale (GCS) score of 5 or more were randomly assigned to 2 group: local mild hypothermia with conventional mannitol (Group A) or conventional mannitol (Group B). SPECT study was performed at day 7 after therapy. The SPECT images were semi-quantitatively analyzed, and the radioactivity ratios of lesion to normal tissue (L/NT) were calculated. National Institutes of Health Stroke Scale (NIHSS) were used in evaluation at days 14 and 21 after therapy.
  
  
  RESULTS
  There were significant differences in NIHSS score at days 14 and 21, and the L/NT ratios between the groups A and B (P < 0.05). Based on GCS, more patients in the group A showed favorable outcomes than patients in the group B (P < 0.05). Furthermore, the L/NT ratios significantly increased in patients with favorable outcomes compared to poor outcomes. Changes in NIHSS score at days 14 and 21 were closely negatively correlated with the L/NT ratios in the groups A and B (r= -0.58, -0.61, and -0.52, -0.75, respectively, P < 0.05).
  
  
  CONCLUSIONS
  Local mild hypothermia could significantly increase rCBF and improve clinical outcome in ICH patients as evaluated by <formula>^{99m}</formula>Tc-ECD SPECT study.
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Xinhui
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Kunmu
authors.initials: K
authors.lastname: Zheng
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Jingxiong
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Guibing
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Su
authors.affiliation: Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Suijun
authors.initials: S
authors.lastname: Tong
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011379:Prognosis; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine
keywords: Local mild hypothermia; SPECT imaging; intracerebral hemorrhage; regional cerebral blood flow