title: A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents.
abstract: PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.
authors.affiliation: Department of Chemistry, Spelman College, Atlanta, GA 30314, USA.
authors.forename: Leyte L
authors.initials: LL
authors.lastname: Winfield
authors.affiliation: Department of Physics, Whitman College, Walla Walla, WA 99362, USA.
authors.forename: Dayle M
authors.initials: DM
authors.lastname: Smith
authors.affiliation: Department of Physics, Whitman College, Walla Walla, WA 99362, USA.
authors.forename: Kalani
authors.initials: K
authors.lastname: Halemano
authors.affiliation: Department of Chemistry, Spelman College, Atlanta, GA 30314, USA.
authors.forename: Carmine S
authors.initials: CS
authors.lastname: Leggett
keywords: 3D Pharmacophore; Anti-proliferative; Benzimidazole; PDK1; Prostate cancer; SAR