title: [Effect of hepatic functional activity of the liver and endogenous intoxication in patients with ovarian cancer].
abstract: The analysis of the clinical observations and the results of the study 70 patients with ovarian cancer stage III-IV, aged 30 to 70 years. After various programs chemotherapy underwent surgical treatment stage under general anesthesia. Investigated hematological indices of intoxication, protein-synthetic liver function, transaminase, C-reactive protein, hemostasis in the perioperative period. Analysis of the results revealed that the original premorbid background characterized by severe hepatic dysfunction, endogenous intoxication, activation of the systemic inflammatory response. The introduction of the treatment of patients with ovarian cancer Remaxol promotes more pronounced and rapid reduction in the degree of metabolic disorders, endogenous intoxication and systemic inflammatory response, compared with ademethionine.
authors.forename: S V
authors.initials: SV
authors.lastname: Tumanian
authors.forename: D V
authors.initials: DV
authors.lastname: Iartseva
mesh_terms: D000328:Adult; D000368:Aged; D057186:Comparative Effectiveness Research; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy / Q000009:adverse effects / Q000379:methods; D059035:Perioperative Period / Q000379:methods; D011379:Prognosis; D020011:Protective Agents / Q000008:administration & dosage; D012426:Russia; D012436:S-Adenosylmethionine / Q000008:administration & dosage*; D012720:Severity of Illness Index; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D020011:Protective Agents; C555877:Remaxol; D013386:Succinates; D012436:S-Adenosylmethionine