title: A new combinatorial method for synthesizing, screening, and discovering antifouling surface chemistries.
abstract: A set of diverse monomers were synthesized using combinatorial chemistry and tested using our unique high-throughput screening platform. The versatility of our platform is exemplified by possible applications in reducing biological fouling on ship hulls, filtration membranes, and surgical instruments, to name a few. To demonstrate its efficacy, the novel monomers were graft-polymerized onto light sensitive poly(ether sulfone) (PES) membranes via atmospheric-pressure plasma polymerization. A diverse library was synthesized by reacting a common vinyl ester linker with a library of maleimides containing various different functional groups. This allowed us to produce a library of many different surfaces and graft them all using the same linker chemistry. The modified surfaces were then tested and screened for the best antiprotein adsorption (nonfouling) properties. Membranes, functionalized with carboxylic acid, zwitterionic, and ester groups, had the lowest protein adhesion compared with that of an unmodified control PES membrane after a static fouling test. After dynamic fouling, these same functionalities as well as a hydroxyl group exhibited the highest permeability. These monomers performed better than our best previously synthesized amide monomers as well as our best poly(ethylene glycol) monomers, which are known to have very high protein resistance. Hansen solubility parameters qualitatively predicted which monomers performed best, indicating favorable interactions with water molecules.
authors.affiliation: Howard P. Isermann Department of Chemical and Biological Engineering and The Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Imbrogno
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Williams
authors.forename: Georges
authors.initials: G
authors.lastname: Belfort
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D008567:Membranes, Artificial; D010539:Permeability; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012995:Solubility; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone; D012710:Serum Albumin, Bovine
keywords: antiprotein fouling surfaces; atmospheric-pressure plasma; combinatorial chemistry; high-throughput screening