title: Sesquiterpenoid tropolone glycosides from Liriosma ovata.
abstract: Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography-quadrupole-orbital ion trap mass spectrometric (UHPLC-Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.
authors.affiliation: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Pawar
authors.forename: Erich
authors.initials: E
authors.lastname: Grundel
authors.forename: Eugene P
authors.initials: EP
authors.lastname: Mazzola
authors.forename: Clark D
authors.initials: CD
authors.lastname: Ridge
authors.forename: Takashi
authors.initials: T
authors.lastname: Masaoka
authors.forename: Stuart F J
authors.initials: SF
authors.lastname: Le Grice
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wilson
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Krynitsky
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031656:Olacaceae / Q000737:chemistry*; D010568:Peru; D018517:Plant Roots / Q000737:chemistry; D016914:Ribonuclease H / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D012717:Sesquiterpenes; C000600276:liriosmaside A; C000600277:liriosmaside B; C560282:oplopanpheside C; D014334:Tropolone; D016914:Ribonuclease H