title: Platelet activity in the pathophysiology of inflammatory bowel diseases.
abstract: Platelets play a crucial role in immune responses. Impaired platelet activation may cause persistent mucosal inflammation through P-selectin, CD40-CD40L and other systems influencing granulocytes, macrophages or endothelial cells. Pharmacological regulation of platelet activation may reduce thromboembolism and limit the interaction of platelets with endothelial and inflammatory cells, in turn weakening the inflammatory responses. In this review we focus on pathophysiological activities of platelets in inflammatory bowel diseases and discuss the studies on currently available anti-platelet therapies in the treatment of gastrointestinal inflammation. Finally, we provide a prospective view to new anti-platelet agents currently under development.
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Chen
authors.forename: Yongyu
authors.initials: Y
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhanju
authors.initials: Z
authors.lastname: Liu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Shi
authors.forename: Urszula
authors.initials: U
authors.lastname: Lewandowska
authors.forename: Marta
authors.initials: M
authors.lastname: Sobczak
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
authors.affiliation: Department of Pathophysiology, Institute of Digestive Disease, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. liyongyu@tongji.edu.cn.
authors.forename: Martin
authors.initials: M
authors.lastname: Kreis
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors