title: Is the measurement of serum ischemia-modified albumin the best test to diagnose ovarian torsion?
abstract: OBJECTIVE
  The aim of this study is to evaluate the diagnostic value of serum oxidative stress marker levels (ischemia-modified albumin, IMA; malondialdehyde, MDA) and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels that occur in ovarian torsion and to determine the threshold value of these markers in the diagnosis of ovarian torsion.
  
  
  METHODS
  In this prospective case-control study, 34 women (the study group) with acute pelvic pain (20 with and 14 without ovarian torsion) and 40 control subjects were included. The diagnosis of ovarian torsion was confirmed with laparoscopy in all cases. Preoperative serum samples were collected in the study group. Serum oxidative stress marker levels (IMA and MDA) and TOS, TAS and OSI levels were measured.
  
  
  RESULTS
  Serum MDA, TOS and IMA concentrations were significantly higher in women with ovarian torsion than in the healthy control group. However, serum TAS, TOS and OSI concentrations were significantly higher in women without ovarian torsion than within the healthy control group. Only IMA significantly distinguished patients with or without ovarian torsion. The best IMA value, according to the receiver operating characteristic curve, was 0.7045 absorbance units, with 90.00% sensitivity and 92.31% specificity. The patients in the ovarian torsion group had significantly lower serum TAS and OSI levels compared with patients without ovarian torsion.
  
  
  CONCLUSIONS
  The elevated serum IMA levels with high sensitivity-specificity values observed in women with ovarian torsion seem to have a potential role as a serum marker in the preoperative diagnosis of ovarian torsion in emergency settings.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Cavit
authors.initials: C
authors.lastname: Kart
authors.forename: Emine Seda
authors.initials: ES
authors.lastname: Guvendag Guven
authors.forename: Esra Can
authors.initials: EC
authors.lastname: Cetin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
mesh_terms: D059787:Acute Pain / Q000209:etiology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006403:Hematologic Tests / Q000592:standards*; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D010049:Ovarian Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D018384:Oxidative Stress / Q000502:physiology*; D017699:Pelvic Pain / Q000209:etiology; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D054159:Torsion, Mechanical
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human