title: The effect of treadmill exercise on inflammatory responses in rat model of streptozotocin-induced experimental dementia of Alzheimer's type.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of treadmill exercise on inflammatory response in streptozotocin (STZ)-induced animal model of Alzheimer's disease (AD).
  
  
  METHODS
  To induce the animal model of AD, Sprague-Dawley rats were injected into intracerebroventricular (ICV) injection with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n = 7), STZ-con group (n = 7) and STZ-exe group (n = 7). Exercise group ran on the treadmill for 30 min/day, 5 days/week during 6 weeks.
  
  
  RESULTS
  The results of this study were as follows: First, STZ-exe group was improved on cognitive function when compared to STZ-con group in water maze test. Second, STZ-exe group help reduce the expression level of amyloid-beta (Aβ). In addition, Toll-like receptors-4 (TLR4), Nuclear factor-kB (NF-kB), Tumor necrosis factor-α (TNF-α) and Interleukin-1α (IL-1α) level of STZ-exe group was significantly decreased when compared to STZ-con group.
  
  
  CONCLUSIONS
  These results show that treadmill exercise had positive effect on cognitive function and reduced inflammatory response in STZ-induced animal model of AD.
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: In Su
authors.initials: IS
authors.lastname: Kwon
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Koo
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Jang
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Eun Bum
authors.initials: EB
authors.lastname: Kang
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Byun
authors.affiliation: Department of exercise prescription, Kon-Yang University, 121 Daehak-ro, Nosan chugnam 320-711, Korea.
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Um
authors.affiliation: Department of physical education, Chosun University, 309 Pilmun-daero Dong-gu Gwangju 501-759, Korea.
authors.forename: Hoo Seong
authors.initials: HS
authors.lastname: Park
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Dong Cheol
authors.initials: DC
authors.lastname: Yeom
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: In Ho
authors.initials: IH
authors.lastname: Cho
authors.affiliation: Exercise Biochemistry Lab, Korea National Sport University, 88-15 Oryun-dong, Songpa-gu, Seoul, 138-763, Korea.
authors.forename: Joon Yong
authors.initials: JY
authors.lastname: Cho
keywords: Alzheimer’s disease; Amyloid-beta; Inflammatory; Streptozotocin; Treadmill exercise