title: Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
abstract: Studies in flies, mice, and human models have provided a conceptual framework for how paracrine interactions between damaged cells and the surrounding tissue control tissue repair. These studies have amassed evidence for an evolutionarily conserved secretory program that regulates tissue homeostasis. This program coordinates cell survival and proliferation during tissue regeneration and repair in young animals. By virtue of chronic engagement, however, it also contributes to the age-related decline of tissue homeostasis leading to degeneration, metabolic dysfunction, and cancer. Here, we review recent studies that shed light on the nature and regulation of this evolutionarily conserved secretory program.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Joana
authors.initials: J
authors.lastname: Neves
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Demaria
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94520, USA. Electronic address: jcampisi@buckinstitute.org.
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: hjasper@buckinstitute.org.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Jasper
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D004175:Diptera; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D014945:Wound Healing / Q000502:physiology*