title: Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: a meta-analysis.
abstract: BACKGROUND
  This was controversial whether vitamin E-coated dialyzer therapy was beneficial for the complications associated with hemodialysis. Therefore, we performed this systematic review to evaluate the effects of vitamin E-coated dialyzer.
  
  
  METHODS
  Related trials were searched from multiple electronic databases. We conducted meta-analysis to assess changes in the predefined outcomes using RevMan 5.3 software.
  
  
  RESULTS
  Meta-analysis showed vitamin E-coated dialyzer therapy could decrease erythropoietin (EPO) resistance index (SMD, -0.24; 95% CI, -0.47 to -0.01; p = 0.04). However, pooled-analysis showed vitamin E-coated dialyzer therapy could not decrease weekly EPO dose (SMD, -0.11; 95% CI, -0.32 to 0.09; p = 0.28) and intima-media thickness (IMT) of the carotid artery (MD, -0.09; 95% CI, -0.2 to 0.01; p = 0.09), and vitamin E-coated dialyzer therapy did not improve the serum hemoglobin (MD, -0.03; 95% CI, -0.18 to 0.13; p = 0.74), albumin levels (SMD, -0.64; 95% CI, -1.62 to 0.34; p = 0.2), in addition, there was no significant difference in serum cholesterol (SMD, -0.07; 95% CI, -0.45 to 0.31; p = 0.71), triglycerides (MD, -2.77; 95% CI, -32.42 to 26.87; p = 0.85), high density lipoprotein (HDL) (SMD, 0.24; 95% CI, -0.14 to 0.62; p = 0.22) and low density lipoprotein (LDL) (SMD, 0.00; 95% CI, -0.38 to 0.37; p = 0.98) levels.
  
  
  CONCLUSIONS
  Vitamin E-coated dialyzer may reduce the EPO resistance, but there is no conclusive evidence that vitamin E-coated dialyzer can improve the renal anemia, malnutrition, dyslipidemia and atherosclerosis status in hemodialysis (HD) patients. However, high-quality trials with hard clinical endpoints are required to fully elucidate the clinical value of vitamin E-coated dialyzer therapy.
authors.affiliation: Department of Nephrology, The Third Xiangya Hospital, Central South University , Changsha, Hunan Province , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Yi
authors.forename: Ai-Mei
authors.initials: AM
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000740:Anemia / Q000175:diagnosis / Q000209:etiology; D000975:Antioxidants / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D050171:Dyslipidemias / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008567:Membranes, Artificial; D009752:Nutritional Status / Q000187:drug effects*; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D014810:Vitamin E
keywords: Dialyzer; hemodialysis; meta-analysis; vitamin E