title: Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds.
abstract: Polyethylene oxide (PEO)/chitosan (CS)/graphene oxide (GO) electrospun nanofibrous scaffolds were successfully developed via electrospinning process for controlled release of doxorubicin (DOX). The SEM analysis of nanofibrous scaffolds with different contents of GO (0.1, 0.2, 0.5 and 0.7wt.%) indicated that the minimum diameter of nanofibers was found to be 85nm for PEO/CS/GO 0.5% nanofibers. The π-π stacking interaction between DOX and GO with fine pores of nanofibrous scaffolds exhibited higher drug loading (98%) and controlled release of the DOX loaded PEO/CS/GO nanofibers. The results of DOX release from nanofibrous scaffolds at pH5.3 and 7.4 indicated strong pH dependence. The hydrogen bonding interaction between GO and DOX could be unstable under acidic conditions which resulted in faster drug release rate in pH5.3. The cell viability results indicated that DOX loaded PEO/CS/GO/DOX nanofibrous scaffold could be used as an alternative source of DOX compared with free DOX to avoid the side effects of free DOX. Thus, the prepared nanofibrous scaffold offers as a novel formulation for treatment of lung cancer.
authors.affiliation: Faculty of Chemical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Ardeshirzadeh
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Nadia Aboutalebi
authors.initials: NA
authors.lastname: Anaraki
authors.affiliation: Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Ave., P.O. Box 15875-4413, Tehran, Iran; Medical Biomaterials Research Center (MBRC), Tehran University of Medical Science, Tehran, Iran. Electronic address: irani_mo@ut.ac.ir.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Irani
authors.affiliation: Medical Biomaterials Research Center (MBRC), Tehran University of Medical Science, Tehran, Iran.
authors.forename: Leila Roshanfekr
authors.initials: LR
authors.lastname: Rad
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Soodeh
authors.initials: S
authors.lastname: Shamshiri
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D011092:Polyethylene Glycols; D006108:Graphite; D004317:Doxorubicin; D048271:Chitosan
keywords: Cell viability; Controlled drug release; Doxorubicin; Graphene oxide; Nanofibrous scaffold