title: Long-term effects of continuous theta-burst stimulation in visuospatial neglect.
abstract: OBJECTIVE
  To investigate whether the efficacy of continuous theta-burst stimulation (cTBS) for improving visuospatial neglect can be enhanced by providing more days of stimulation and more stimulation trains per day.
  
  
  METHODS
  In a prospective study, right-handed patients with right hemisphere stroke and visuospatial neglect were randomized to cTBS or sham cTBS treatment for 2 weeks and were followed up for 4 weeks. The cTBS group received active cTBS over the posterior parietal cortex of the unaffected hemisphere, combined with conventional rehabilitation therapy. Changes in scores for two paper-pencil tests for visuospatial neglect (star cancellation and line bisection) were evaluated.
  
  
  RESULTS
  In each group, 10 patients completed follow up. Compared with the sham group, star cancellation test scores in the cTBS group were improved by 37.03% at the end of treatment and by 47.21% after 4 weeks' follow up, and the line bisection score improved by 21.37% at the end of treatment and by 35.99% after 4 weeks' follow up.
  
  
  CONCLUSIONS
  These results suggest that the efficacy of cTBS in visuospatial neglect can be enhanced and prolonged by increasing the days of stimulation and the number of stimulation trains per day over the left posterior parietal cortex.
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China Department of Neurology, Beijing Electric Power Hospital, State Grid Corporation of China, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China songwq66@163.com.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuanbin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Su
authors.initials: S
authors.lastname: Huo
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Maobin
authors.initials: M
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010468:Perceptual Disorders / Q000628:therapy*; D011446:Prospective Studies; D020521:Stroke / Q000628:therapy*; D013995:Time; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome
keywords: Visuospatial neglect; interhemispheric rivalry; neurorehabilitation; repetitive transcranial magnetic stimulation