title: The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients.
abstract: Endovascular treatment (ET) showed to be safe in acute stroke, but its superiority over intravenous thrombolysis is debated. As ET is rapidly evolving, it is not clear which role it may deserve in the future of stoke treatments. Based on an observational design, a treatment registry allows to study a broad range of patients, turning into a powerful tool for patients' selection. We report the methodology and a descriptive analysis of patients from a national registry of ET for stroke. The Italian Registry of Endovascular Treatment in Acute Stroke is a multicenter, observational registry running in Italy from 2010. All patients treated with ET in the participating centers were consecutively recorded. Safety measures were symptomatic intracranial hemorrhage, procedural adverse events and death rate. Efficacy measures were arterial recanalization and 3-month good functional outcome. From 2008 to 2012, 960 patients were treated in 25 centers. Median age was 67 years, male gender 57 %. Median baseline NIHSS was 17. The most frequent occlusion site was Middle cerebral artery (46.9 %). Intra-arterial thrombolytics were used in 165 (17.9 %) patients, in 531 (57.5 %) thrombectomy was employed, and 228 (24.7 %) patients received both treatments. Baseline features of this cohort are in line with data from large clinical series and recent trials. This registry allows to collect data from a real practice scenario and to highlight time trends in treatment modalities. It can address unsolved safety and efficacy issues on ET of stroke, providing a useful tool for the planning of new trials.
authors.affiliation: Interventional Neuroradiology Unit, "Careggi" University Hospital, Florence, Italy, coordinamento@registroendovascolare.it.
authors.forename: Salvatore
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authors.lastname: Mangiafico
authors.forename: Giovanni
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authors.lastname: Pracucci
authors.forename: Valentina
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authors.lastname: Saia
authors.forename: Patrizia
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authors.lastname: Nencini
authors.forename: Domenico
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authors.lastname: Inzitari
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authors.lastname: Cerrato
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authors.forename: Alessandro
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authors.forename: Marialuisa
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authors.lastname: DeLodovici
authors.forename: Nicola
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authors.lastname: Cavasin
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authors.lastname: Gallucci
authors.forename: Antonio
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authors.lastname: Carolei
authors.forename: Teodoro
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authors.lastname: Meloni
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authors.lastname: Corso
authors.forename: Giacomo
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authors.lastname: Vaudano
authors.forename: Enrica
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authors.lastname: Duc
authors.forename: Federico
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authors.lastname: Zappoli
authors.forename: Anna
authors.initials: A
authors.lastname: Cavallini
authors.forename: Riccardo
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authors.lastname: Padolecchia
authors.forename: Tiziana
authors.initials: T
authors.lastname: Tassinari
authors.forename: Marco
authors.initials: M
authors.lastname: Longoni
authors.forename: Andrea
authors.initials: A
authors.lastname: Salmaggi
authors.forename: PierGiuseppe
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authors.lastname: Zampieri
authors.forename: Paolo
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authors.lastname: Bovi
authors.forename: Michele
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authors.lastname: Puglioli
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiti
authors.forename: Giulio
authors.initials: G
authors.lastname: Guidetti
authors.forename: Luigi
authors.initials: L
authors.lastname: Simonetti
authors.forename: Gaetano
authors.initials: G
authors.lastname: Procaccianti
authors.forename: Roberto
authors.initials: R
authors.lastname: Menozzi
authors.forename: Umberto
authors.initials: U
authors.lastname: Scoditti
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ricciardi
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Pezzella
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Guarnieri
authors.forename: Vincenzo
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authors.lastname: Andreone
authors.forename: Danilo
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authors.lastname: Toni
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000628:therapy; D007558:Italy; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D012042:Registries / Q000706:statistics & numerical data*; D020521:Stroke / Q000628:therapy*; D017131:Thrombectomy / Q000009:adverse effects / Q000706:statistics & numerical data*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000706:statistics & numerical data*