title: Total glutamine synthetase levels in cerebrospinal fluid of Alzheimer's disease patients are unchanged.
abstract: Decreased cerebral protein and activity levels of glutamine synthetase (GS) have been reported for Alzheimer's disease (AD) patients. Using a recently established method, we quantified total GS levels in cerebrospinal fluid (CSF) from AD patients and control subjects. Furthermore, we investigated if total GS levels in CSF could differentiate AD from frontotemperal dementia and dementia with Lewy bodies patients. As we found no significantly altered total GS levels in any of the patient groups compared with control subjects, we conclude that levels of total GS in CSF have no diagnostic value for AD, dementia with Lewy bodies, or frontotemperal dementia.
authors.affiliation: Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Nienke M
authors.initials: NM
authors.lastname: Timmer
authors.affiliation: Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Megan K
authors.initials: MK
authors.lastname: Herbert
authors.affiliation: Department of Geriatric Medicine, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Jurgen A H R
authors.initials: JA
authors.lastname: Claassen
authors.affiliation: Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: H Bea
authors.initials: HB
authors.lastname: Kuiperij
authors.affiliation: Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Marcel.Verbeek@radboudumc.nl.
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Verbeek
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis; D005974:Glutamate-Ammonia Ligase / Q000134:cerebrospinal fluid*; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis; D008297:Male
chemical_list: D015415:Biomarkers; D005974:Glutamate-Ammonia Ligase
keywords: Alzheimer's disease; Cerebrospinal fluid; Dementia with Lewy bodies; Frontotemporal dementia; Glutamine synthetase