title: Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.
abstract: Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
authors.affiliation: Department of Viroscience, Erasmus Medical Center.
authors.forename: Carolien E
authors.initials: CE
authors.lastname: van de Sandt
authors.affiliation: Department of Viroscience, Erasmus Medical Center.
authors.forename: Marine L B
authors.initials: ML
authors.lastname: Hillaire
authors.affiliation: Department of Viroscience, Erasmus Medical Center.
authors.forename: Martina M
authors.initials: MM
authors.lastname: Geelhoed-Mieras
authors.affiliation: Department of Viroscience, Erasmus Medical Center ViroClinics Biosciences, Rotterdam, The Netherlands.
authors.forename: Albert D M E
authors.initials: AD
authors.lastname: Osterhaus
authors.affiliation: Department of Viroscience, Erasmus Medical Center.
authors.forename: Ron A M
authors.initials: RA
authors.lastname: Fouchier
authors.affiliation: Department of Viroscience, Erasmus Medical Center ViroClinics Biosciences, Rotterdam, The Netherlands.
authors.forename: Guus F
authors.initials: GF
authors.lastname: Rimmelzwaan
mesh_terms: D000293:Adolescent; D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007251:Influenza, Human / Q000276:immunology*; D029521:Alphainfluenzavirus / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013997:Time Factors; D055815:Young Adult
keywords: CD8+ T cells; human; immunity; influenza A virus; longevity