title: The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer.
abstract: The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPARγ is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPARγ is necessary to reduce the incidence of metabolic diseases and cancer.
authors.affiliation: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120-749, Korea.
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Jaewhan
authors.initials: J
authors.lastname: Song
authors.forename: Kye Won
authors.initials: KW
authors.lastname: Park
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000473:pathology; D050356:Lipid Metabolism / Q000502:physiology; D008659:Metabolic Diseases / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D047495:PPAR gamma / Q000378:metabolism*; D015995:Prevalence
chemical_list: D047495:PPAR gamma