title: Antioxidant intake and bone status in a cross-sectional study of Brazilian women with osteoporosis.
abstract: This study aimed to investigate the association between antioxidant intake and bone mineral density (BMD) in postmenopausal women with osteoporosis. We conducted a cross-sectional study with 150 women, mean age 68.7 (SD 9.1) years. BMD and body composition were obtained using dual-energy X-ray absorptiometry (DXA). We assessed anthropometric measures and dietary intake and applied an adapted Dietary Antioxidant Quality Score (a-DAQS) to evaluate the antioxidant consumption. 65.3% of women had higher scores on the a-DAQS. We found no relationship between the a-DAQS and BMD; however, we observed an inverse correlation between vitamin A and lumbar spine (LS) BMD in g/cm(2) (r = - 0.201; p = 0.013). An analysis of variance (ANOVA) test also showed that vitamin A was negatively associated with the LS BMD (F = 6.143; p = 0.013, but without significance when a multivariate analysis was applied. The a-DAQS did not have an association with BMD; however, Vitamin A showed a negative correlation with BMD, but such an association disappeared when the other antioxidants were taken together. Our findings encourage an antioxidant-based dietary approach to osteoporosis prevention and treatment, since the negative effect of vitamin A was neutralized by the intake of such nutrients.
authors.affiliation: Department of Nutrition, School of Public Health, Sao Paulo University, Sao Paulo, Brazil Food and Nutrition Research Center (NAPAN), Sao Paulo, Brazil.
authors.forename: Natasha A G
authors.initials: NA
authors.lastname: De França
authors.affiliation: Division of Endocrinology, School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Marilia B R
authors.initials: MB
authors.lastname: Camargo
authors.affiliation: Division of Endocrinology, School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Marise
authors.initials: M
authors.lastname: Lazaretti-Castro
authors.affiliation: Department of Nutrition, School of Public Health, Sao Paulo University, Sao Paulo, Brazil Food and Nutrition Research Center (NAPAN), Sao Paulo, Brazil lmartini@usp.br.
authors.forename: Lígia Araújo
authors.initials: LA
authors.lastname: Martini
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000008:administration & dosage*; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects; D001938:Brazil / Q000453:epidemiology; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D009043:Motor Activity; D010024:Osteoporosis / Q000188:drug therapy* / Q000453:epidemiology*; D014131:Trace Elements; D014801:Vitamin A / Q000008:administration & dosage; D014807:Vitamin D / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage; D055105:Waist Circumference
chemical_list: D000975:Antioxidants; D002136:Calcium, Dietary; D014131:Trace Elements; D014815:Vitamins; D014801:Vitamin A; D014807:Vitamin D
keywords: Antioxidants; bone mineral density; dietary antioxidant quality score; lumbar spine; osteoporosis; postmenopausal women; vitamin A