title: Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
abstract: The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the relationship between single nucleotide polymorphisms (SNPs) in genes encoding key CPC components and breast cancer risk. Fifteen SNPs in four CPC genes (INCENP, AURKB, BIRC5 and CDCA8) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium. Possible associations were investigated in fixed-effects meta-analyses. The synonymous SNP rs1675126 in exon 7 of INCENP was associated with overall breast cancer risk [per A allele odds ratio (OR) 0.95, 95% confidence interval (CI) 0.92-0.98, P = 0.007] and particularly with estrogen receptor (ER)-negative breast tumors (per A allele OR 0.89, 95% CI 0.83-0.95, P = 0.0005). SNPs not directly genotyped were imputed based on 1000 Genomes. The SNPs rs1047739 in the 3' untranslated region and rs144045115 downstream of INCENP showed the strongest association signals for overall (per T allele OR 1.03, 95% CI 1.00-1.06, P = 0.0009) and ER-negative breast cancer risk (per A allele OR 1.06, 95% CI 1.02-1.10, P = 0.0002). Two genotyped SNPs in BIRC5 were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04-1.21, P = 0.002). The data suggest that INCENP in the CPC pathway contributes to ER-negative breast cancer susceptibility in the European population. In spite of a modest contribution of CPC-inherited variants to the total burden of sporadic and familial breast cancer, their potential as novel targets for breast cancer treatment should be further investigated.
authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Kabisch
authors.affiliation: Institute of Medical Biometry and Informatics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Justo
authors.initials: J
authors.lastname: Lorenzo Bermejo
authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dünnebier
authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Shibo
authors.initials: S
authors.lastname: Ying
authors.affiliation: Department of Public Health and Primary Care and.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Michailidou
authors.affiliation: Department of Public Health and Primary Care and.
authors.forename: Manjeet K
authors.initials: MK
authors.lastname: Bolla
authors.affiliation: Department of Public Health and Primary Care and.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Public Health and Primary Care and.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Mitul
authors.initials: M
authors.lastname: Shah
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Perkins
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Kamila
authors.initials: K
authors.lastname: Czene
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Hatef
authors.initials: H
authors.lastname: Darabi
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Eriksson
authors.affiliation: Copenhagen General Population Study, Department of Clinical Biochemistry, and.
authors.forename: Stig E
authors.initials: SE
authors.lastname: Bojesen
authors.affiliation: Copenhagen General Population Study, Department of Clinical Biochemistry, and.
authors.forename: Børge G
authors.initials: BG
authors.lastname: Nordestgaard
authors.affiliation: Copenhagen General Population Study, Department of Clinical Biochemistry, and.
authors.forename: Sune F
authors.initials: SF
authors.lastname: Nielsen
authors.affiliation: Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Flyger
authors.affiliation: Vesalius Research Center, VIB, 3000 Leuven, Belgium, Department of Oncology, Laboratory for Translational Genetics, University of Leuven, 3000 Leuven, Belgium.
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.affiliation: Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Neven
authors.affiliation: Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Peeters
authors.affiliation: Department of Oncology, KU Leuven (University of Leuven), Multidisciplinary Breast Center, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Weltens
authors.affiliation: Department of Laboratory Medicine and Pathology and.
authors.forename: Fergus J
authors.initials: FJ
authors.lastname: Couch
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Janet E
authors.initials: JE
authors.lastname: Olson
authors.affiliation: Department of Laboratory Medicine and Pathology and.
authors.forename: Xianshu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Karmanos Cancer Institute, Detroit, MI 48201, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Purrington
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Rudolph
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Seibold
authors.affiliation: Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Flesch-Janys
authors.affiliation: Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Peto
authors.affiliation: Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
authors.forename: Isabel
authors.initials: I
authors.lastname: dos-Santos-Silva
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
authors.forename: Nichola
authors.initials: N
authors.lastname: Johnson
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
authors.forename: Olivia
authors.initials: O
authors.lastname: Fletcher
authors.affiliation: Department of Obstetrics and Gynecology.
authors.forename: Heli
authors.initials: H
authors.lastname: Nevanlinna
authors.affiliation: Department of Obstetrics and Gynecology.
authors.forename: Taru A
authors.initials: TA
authors.lastname: Muranen
authors.affiliation: Department of Clinical Genetics and.
authors.forename: Kristiina
authors.initials: K
authors.lastname: Aittomäki
authors.affiliation: Department of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
authors.forename: Carl
authors.initials: C
authors.lastname: Blomqvist
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
authors.forename: Marjanka K
authors.initials: MK
authors.lastname: Schmidt
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
authors.forename: Annegien
authors.initials: A
authors.lastname: Broeks
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
authors.forename: Sten
authors.initials: S
authors.lastname: Cornelissen
authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.
authors.forename: Frans B L
authors.initials: FB
authors.lastname: Hogervorst
authors.affiliation: Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Judith S
authors.initials: JS
authors.lastname: Brand
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Keith
authors.initials: K
authors.lastname: Humphreys
authors.affiliation: National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, 94807 Villejuif, France, University Paris-Sud, 94807 Villejuif, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Guénel
authors.affiliation: National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, 94807 Villejuif, France, University Paris-Sud, 94807 Villejuif, France.
authors.forename: Thérèse
authors.initials: T
authors.lastname: Truong
authors.affiliation: National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, 94807 Villejuif, France, University Paris-Sud, 94807 Villejuif, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Menegaux
authors.affiliation: National Institute of Health and Medical Research, Center for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, 94807 Villejuif, France, University Paris-Sud, 94807 Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany, National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Frederik
authors.initials: F
authors.lastname: Marmé
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Rongxi
authors.initials: R
authors.lastname: Yang
authors.affiliation: Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.affiliation: Human Genotyping-CEGEN Unit and.
authors.forename: Anna
authors.initials: A
authors.lastname: González-Neira
authors.forename: Javier
authors.initials: J
authors.lastname: Benitez
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pilar Zamora
authors.affiliation: Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain.
authors.forename: Jose I
authors.initials: JI
authors.lastname: Arias Perez
authors.affiliation: Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Cox
authors.affiliation: Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Cross
authors.affiliation: Department of Oncology, University of Sheffield, Sheffield, S10 2RX, UK.
authors.forename: Malcolm W R
authors.initials: MW
authors.lastname: Reed
authors.affiliation: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
authors.forename: Irene L
authors.initials: IL
authors.lastname: Andrulis
authors.affiliation: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Knight
authors.affiliation: ON Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
authors.forename: Gord
authors.initials: G
authors.lastname: Glendon
authors.affiliation: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Tchatchou
authors.affiliation: Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Elinor J
authors.initials: EJ
authors.lastname: Sawyer
authors.affiliation: Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.affiliation: Clinical Science Institute, University Hospital Galway, Galway, Ireland.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kerin
authors.affiliation: Clinical Science Institute, University Hospital Galway, Galway, Ireland.
authors.forename: Nicola
authors.initials: N
authors.lastname: Miller
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Fredrick
authors.initials: F
authors.lastname: Schumacher
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.affiliation: Department of Molecular Medicine and Surgery and.
authors.forename: Annika
authors.initials: A
authors.lastname: Lindblom
authors.affiliation: Department of Oncology - Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Margolin
authors.affiliation: Department of Medical Oncology and.
authors.forename: Maartje J
authors.initials: MJ
authors.lastname: Hooning
authors.affiliation: Department of Medical Oncology and.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Hollestelle
authors.affiliation: Department of Medical Oncology and.
authors.forename: Mieke
authors.initials: M
authors.lastname: Kriege
authors.affiliation: Department of Surgical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
authors.forename: Linetta B
authors.initials: LB
authors.lastname: Koppert
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and.
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Tsimiklis
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and.
authors.forename: Carmel
authors.initials: C
authors.lastname: Apicella
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Slettedahl
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Toland
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Celine
authors.initials: C
authors.lastname: Vachon
authors.affiliation: Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 153 10 Athens, Greece.
authors.forename: Drakoulis
authors.initials: D
authors.lastname: Yannoukakos
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.affiliation: Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria 3004, Australia.
authors.forename: Catriona
authors.initials: C
authors.lastname: McLean
authors.forename: Peter A
authors.initials: PA
authors.lastname: Fasching
authors.affiliation: Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ruebner
authors.affiliation: Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany, Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
authors.forename: Arif B
authors.initials: AB
authors.lastname: Ekici
authors.affiliation: Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
authors.forename: Aida K
authors.initials: AK
authors.lastname: Dieffenbach
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Arndt
authors.affiliation: Saarland Cancer Registry, 66119 Saarbrücken, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Stegmaier
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Orr
authors.affiliation: Division of Genetics and Epidemiology and.
authors.forename: Minouk J
authors.initials: MJ
authors.lastname: Schoemaker
authors.affiliation: Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: Swerdlow
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK, Division of Genetics and Epidemiology and.
authors.forename: Montserrat
authors.initials: M
authors.lastname: García-Closas
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
authors.forename: Jonine
authors.initials: J
authors.lastname: Figueroa
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.affiliation: Department of Medicine, McGill University, Montreal, QC, H3G 2M1, Canada, Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3G 2M1, Canada.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Goldberg
authors.affiliation: Département de santé environnementale et santé au travail, Département de médecine sociale et preventive, École de santé publique, Université de Montréal, Montreal, QC, H3T 1A8, Canada.
authors.forename: France
authors.initials: F
authors.lastname: Labrèche
authors.affiliation: Centre Hospitalier Universitaire de Québec Research Center and Laval University, QC, G1V 4G2, Canada.
authors.forename: Martine
authors.initials: M
authors.lastname: Dumont
authors.affiliation: Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
authors.forename: Robert
authors.initials: R
authors.lastname: Winqvist
authors.affiliation: Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Pylkäs
authors.affiliation: Department of Oncology and.
authors.forename: Arja
authors.initials: A
authors.lastname: Jukkola-Vuorinen
authors.affiliation: Department of Surgery, Oulu University Hospital, University of Oulu, FI-90220 Oulu, Finland.
authors.forename: Mervi
authors.initials: M
authors.lastname: Grip
authors.forename: Hiltrud
authors.initials: H
authors.lastname: Brauch
authors.affiliation: Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), 44789 Bochum, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brüning
authors.affiliation: Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany.
authors.forename: Yon-Dschun
authors.initials: YD
authors.lastname: Ko
authors.affiliation: Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Radice
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Peterlongo
authors.affiliation: Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
authors.forename: Giulietta
authors.initials: G
authors.lastname: Scuvera
authors.affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy, Cogentech Cancer Genetic Test Laboratory, 20139 Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fortuzzi
authors.affiliation: Department of Radiation Oncology and.
authors.forename: Natalia
authors.initials: N
authors.lastname: Bogdanova
authors.affiliation: Department of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
authors.forename: Thilo
authors.initials: T
authors.lastname: Dörk
authors.forename: Arto
authors.initials: A
authors.lastname: Mannermaa
authors.forename: Vesa
authors.initials: V
authors.lastname: Kataja
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kosma
authors.forename: Jaana M
authors.initials: JM
authors.lastname: Hartikainen
authors.affiliation: Department of Human Genetics and Department of Pathology.
authors.forename: Peter
authors.initials: P
authors.lastname: Devilee
authors.affiliation: Department of Surgical Oncology and.
authors.forename: Robert A E M
authors.initials: RA
authors.lastname: Tollenaar
authors.affiliation: Department of Medical Oncology and.
authors.forename: Caroline
authors.initials: C
authors.lastname: Seynaeve
authors.affiliation: Department of Clinical Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.
authors.forename: Christi J
authors.initials: CJ
authors.lastname: Van Asperen
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jaworska-Bieniek
authors.affiliation: Department of Genetics and Pathology, Pomeranian Medical University, 70-115 Szczecin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Durda
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Shrubsole
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, Institute of Human Genetics, Pontificia Universidad Javeriana, 11001000 Bogotá, Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Torres
authors.affiliation: Department of Epidemiology, University of California Irvine, Irvine, CA 92697, USA.
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.forename: Vessela
authors.initials: V
authors.lastname: Kristensen
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, QC H3A 0G1, Canada and.
authors.forename: François
authors.initials: F
authors.lastname: Bacot
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, QC H3A 0G1, Canada and.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Tessier
authors.affiliation: McGill University and Génome Québec Innovation Centre, Montréal, QC H3A 0G1, Canada and.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vincent
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Craig
authors.initials: C
authors.lastname: Luccarini
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Caroline
authors.initials: C
authors.lastname: Baynes
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Shahana
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Mel
authors.initials: M
authors.lastname: Maranian
authors.affiliation: Centre Hospitalier Universitaire de Québec Research Center and Laval University, QC, G1V 4G2, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Simard
authors.affiliation: Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-17177, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Hall
authors.affiliation: Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain.
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.affiliation: Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.affiliation: Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.affiliation: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, u.hamann@dkfz-heidelberg.de.
authors.forename: Ute
authors.initials: U
authors.lastname: Hamann
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D064107:Aurora Kinase B / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000378:metabolism*; D012306:Risk; D000077022:Survivin; D044465:White People / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; C107489:BIRC5 protein, human; C490157:CDCA8 protein, human; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C083767:INCENP protein, human; D051034:Inhibitor of Apoptosis Proteins; D011960:Receptors, Estrogen; D000077022:Survivin; C576921:AURKB protein, human; D064107:Aurora Kinase B