title: Surgical implications of asymmetric distribution of dermal collagen and elastic fibres in two orientations of skin samples from extremities.
abstract: Background. Clinically, scar related complications are observed to be dissimilar in different regions of the body. Unequal distribution of dermal collagen and elastic fibres in different orientations could be one of the multifocal causes of scar related complications, for which this evaluating study has been taken up. Materials and Method. 300 skin samples collected in horizontal and vertical orientations were studied histomorphometrically. This study involved image analysis of specially stained histological section using tissue-quant software. The outcome result was termed as quantitative fraction. From the result, various ratio values were also calculated for the ratio analysis. Results. The differences in the quantitative fraction of dermal elastic content between 2 directions were statistically significant at joint areas (shoulder joint, wrist, and ankle) (P < 0.001) but for collagen, significant difference was observed at shoulder joint and wrist only. Dermis of the forearm and thigh did not show any differences in their collagen content, but for elastic, thigh did show a significant difference while forearm had no change between 2 directions. Conclusion. Analysis of unequal content of dermal element in two directions under the perspective of wound healing consequences is subjective depending upon the anatomical position and functional status of the areas.
authors.affiliation: Department of Anatomy, Melaka Manipal Medical College, Manipal Campus, Manipal University, Manipal 576104, India.
authors.forename: Naveen
authors.identifier: 0000-0003-2805-779X
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Plastic Surgery, King Abdul Aziz Hospital, Sakaka, Al-Jouf 42421, Saudi Arabia.
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Anatomy, Melaka Manipal Medical College, Manipal Campus, Manipal University, Manipal 576104, India.
authors.forename: Satheesha
authors.initials: S
authors.lastname: Nayak Badagabettu
authors.affiliation: Department of Information Science, Manipal School of Information Science, Manipal University, Manipal 576104, India.
authors.forename: Keerthana
authors.initials: K
authors.lastname: Prasad
authors.affiliation: Department of Pathology, Kasturba Medical College, Manipal University, Manipal 576104, India.
authors.forename: Ranjini
authors.initials: R
authors.lastname: Kudva
authors.affiliation: Department of Pathology, Yenepoya University, Deralakatte, Mangalore 575018, India.
authors.forename: Raghuveer Coimbatore
authors.initials: RC
authors.lastname: Vasudevarao