title: Evolution of small guide RNA genes in hyperthermophilic archaea.
abstract: Profiling the RNA production in hyperthermophilic archaea revealed an abundance of small RNA-guided processes near the upper temperature limit of life. Archaea utilize the base-pairing ability of RNA guide sequences to target ribosomal RNAs, transfer RNAs, messenger RNAs, and viral genomes. Cellular processes that are guided by small RNAs include the modification of RNA molecules, trans-splicing, gene regulation, and RNA and DNA degradation. Here, a brief overview of our knowledge on small guide RNA genes in archaeal genomes is provided and examples of their putative roles in genome evolution are described.
authors.affiliation: Prokaryotic Small RNA Biology, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
authors.forename: Lennart
authors.initials: L
authors.lastname: Randau
mesh_terms: D001105:Archaea / Q000235:genetics*; D001483:Base Sequence; D019143:Evolution, Molecular; D019848:Gene Expression Regulation, Archaeal; D020745:Genome, Archaeal / Q000235:genetics; D006358:Hot Temperature; D008957:Models, Genetic; D019642:RNA, Archaeal / Q000235:genetics* / Q000378:metabolism; D000094704:RNA, Guide, CRISPR-Cas Systems / Q000235:genetics* / Q000378:metabolism
chemical_list: D019642:RNA, Archaeal; D000094704:RNA, Guide, CRISPR-Cas Systems
keywords: C/D box sRNAs; CRISPR; archaea; genome rearrangements; transfer RNA fragments; virus defense