title: Organic carbamates in drug design and medicinal chemistry.
abstract: The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug-target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
authors.forename: Margherita
authors.initials: M
authors.lastname: Brindisi
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004355:Drug Stability; D016333:HIV Protease; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors; D012324:RNA-Dependent RNA Polymerase
chemical_list: D053829:Amyloid Precursor Protein Secretases; D000998:Antiviral Agents; D002219:Carbamates; D015853:Cysteine Proteinase Inhibitors; D016333:HIV Protease; D017320:HIV Protease Inhibitors; D011355:Prodrugs; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase; C514803:p16 protease, Human immunodeficiency virus 1