title: Increased hydrostatic pressure enhances motility of lung cancer cells.
abstract: Interstitial fluid pressures within most solid tumors are significantly higher than that in the surrounding normal tissues. Therefore, cancer cells must proliferate and migrate under the influence of elevated hydrostatic pressure while a tumor grows. In this study, we developed a pressurized cell culture device and investigated the influence of hydrostatic pressure on the migration speeds of lung cancer cells (CL1-5 and A549). The migration speeds of lung cancer cells were increased by 50-60% under a 20 mmHg hydrostatic pressure. We also observed that the expressions of aquaporin in CL1-5 and A549 cells were increased under the hydrostatic pressure. Our preliminary results indicate that increased hydrostatic pressure plays an important role in tumor metastasis.
authors.forename: Yu-Chiu
authors.initials: YC
authors.lastname: Kao
authors.forename: Chau-Hwang
authors.initials: CH
authors.lastname: Lee
authors.forename: Po-Ling
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D051398:Aquaporin 1 / Q000378:metabolism; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002465:Cell Movement; D055032:Electron Microscope Tomography; D006696:Holography; D006801:Humans; D006874:Hydrostatic Pressure; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: C496020:AQP1 protein, human; D051398:Aquaporin 1