title: Synthesis and degradation of Schiff bases containing heterocyclic pharmacophore.
abstract: This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. ionut.ledeti@umft.ro.
authors.forename: Ionuţ
authors.initials: I
authors.lastname: Ledeţi
authors.affiliation: Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. anda_creanga@yahoo.com.
authors.forename: Anda
authors.initials: A
authors.lastname: Alexa
authors.affiliation: Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 6 Carol Telbisz, Timisoara 300001, Romania. vbercean@gmail.com.
authors.forename: Vasile
authors.initials: V
authors.lastname: Bercean
authors.affiliation: Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, Timisoara 300115, Romania. gvlase@cbg.uvt.ro.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Vlase
authors.affiliation: Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, Timisoara 300115, Romania. tvlase@cbg.uvt.ro.
authors.forename: Titus
authors.initials: T
authors.lastname: Vlase
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. suta.lenuta@umft.ro.
authors.forename: Lenuţa-Maria
authors.initials: LM
authors.lastname: Şuta
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, Timisoara 300041, Romania. afulias@umft.ro.
authors.forename: Adriana
authors.initials: A
authors.lastname: Fuliaş
mesh_terms: D004355:Drug Stability; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D012545:Schiff Bases; D014230:Triazoles; C045575:1,2,4-triazole