title: Genetic and epigenetic basis of psoriasis pathogenesis.
abstract: Psoriasis is a chronic inflammatory skin disease whose prevalence varies among different populations worldwide. It is a complex multi-factorial disease and the exact etiology is largely unknown. Family based studies have indicated a genetic predisposition; however they cannot fully explain the disease pathogenesis. In addition to genetic susceptibility, environmental as well as gender and age related factors were also been found to be associated. Recently, imbalances in epigenetic networks are indicated to be causative elements in psoriasis. The present knowledge of epigenetic involvement, mainly the DNA methylation, chromatin modifications and miRNA deregulation is surveyed here. An integrated approach considering genetic and epigenetic anomalies in the light of immunological network may explore the pathogenesis of psoriasis.
authors.affiliation: Human Genetics Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata 700108, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Chandra
authors.affiliation: Human Genetics Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata 700108, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Ray
authors.affiliation: Consultant Dermatologist, Uttarpara, Hooghly 712258, India.
authors.forename: Swapan
authors.initials: S
authors.lastname: Senapati
authors.affiliation: Human Genetics Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata 700108, India. Electronic address: rchatterjee@isical.ac.in.
authors.forename: Raghunath
authors.initials: R
authors.lastname: Chatterjee
mesh_terms: D000367:Age Factors; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D059647:Gene-Environment Interaction; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D012737:Sex Factors; D012867:Skin / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D002843:Chromatin; D035683:MicroRNAs
keywords: DNA methylation; Generalized plaque type psoriasis; Genome-wide association study; Histone modifications; Micro RNA; Single nucleotide polymorphism