title: Effect of NaFeEDTA-fortified soy sauce on zinc absorption in children.
abstract: NaFeEDTA has been applied in many foods as an iron fortificant and is used to prevent iron deficiency in Fe-depleted populations. In China, soy sauce is fortified with NaFeEDTA to control iron deficiency. However, it is unclear whether Fe-fortified soy sauce affects zinc absorption. To investigate whether NaFeEDTA-fortified soy sauce affects zinc absorption in children, sixty children were enrolled in this study and randomly assigned to three groups (10 male children and 10 female children in each group). All children received daily 3 mg of (67)Zn and 1.2 mg of dysprosium orally, while the children in the three groups were supplemented with NaFeEDTA-fortified soy sauce (6 mg Fe, NaFeEDTA group), FeSO₄-fortified soy sauce (6 mg Fe, FeSO₄ group), and no iron-fortified soy sauce (control group), respectively. Fecal samples were collected during the experimental period and analyzed for the Zn content, (67)Zn isotope ratio and dysprosium content. The Fe intake from NaFeEDTA-fortified and FeSO₄-fortified groups was significantly higher than that in the control group (P < 0.0001). The daily total Zn intake was not significantly different among the three groups. There were no significant differences in fractional Zn absorption (FZA) (P = 0.3895), dysprosium recovery (P = 0.7498) and Zn absorption (P = 0.5940) among the three groups. Therefore, NaFeEDTA-fortified soy sauce does not affect Zn bioavailability in children.
authors.affiliation: The Key Laboratory of Trace Element Nutrition MOH, Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Room 103, 29 Nan Wei Road, Xuanwu District, Beijing 100050, P.R. China. xgyangcdc@vip.sina.com.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Jinghuan
authors.initials: J
authors.lastname: Wu
authors.forename: Tongxiang
authors.initials: T
authors.lastname: Ren
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.forename: Jianhua
authors.initials: J
authors.lastname: Piao
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D017195:Adolescent Nutritional Physiological Phenomena; D018798:Anemia, Iron-Deficiency / Q000517:prevention & control; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002681:China; D015331:Cohort Studies; D003212:Condiments / Q000009:adverse effects*; D004419:Dysprosium; D004492:Edetic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005243:Feces / Q000737:chemistry; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005296:Ferrous Compounds / Q000009:adverse effects; D005527:Food, Fortified / Q000009:adverse effects*; D006801:Humans; D007408:Intestinal Absorption; D007502:Iron Chelating Agents / Q000009:adverse effects; D019266:Iron, Dietary / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D045730:Soy Foods / Q000009:adverse effects*; D015032:Zinc / Q000032:analysis / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D015033:Zinc Isotopes
chemical_list: D005290:Ferric Compounds; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D019266:Iron, Dietary; D015033:Zinc Isotopes; D004419:Dysprosium; C020748:ferrous sulfate; D004492:Edetic Acid; D015032:Zinc; C019179:Fe(III)-EDTA