title: A new picrotoxane sesquiterpene from the berries of Baccaurea ramiflora with antifungal activity against Colletotrichum gloeosporioides.
abstract: Three picrotoxane sesquiterpenes including one new glycoside and two known constituents, sapidolide A (2) and picrotoximaesin (3), were isolated from the berries of Baccaurea ramiflora. The structure of the new sesquiterpene glycoside, ramifloside (1), was elucidated as 2-one-6α-hydroxy-13-nor-11-picrotoxen-3(15β)-olide 10-O-β-D-glucopyranoside on the basis of extensive spectroscopic analysis. Compounds 1-3 exhibited antifungal activity against Colletotrichum gloeosporioides with MICs of 12.5, 12.5 and 50 μg/mL.
authors.affiliation: a Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences , Guilin 541006 , P.R. China.
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Ning
authors.forename: Si-Si
authors.initials: SS
authors.lastname: Huang
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Ding
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D020231:Colletotrichum / Q000187:drug effects*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D012717:Sesquiterpenes; C000601243:ramifloside
keywords: Baccaurea ramiflora; antifungal activity; picrotoxane; ramifloside; sesquiterpene glycoside