title: A monoclonal antibody against glycoproteins of Aspergillus fumigatus shows anti-adhesive potential.
abstract: There has been an increase in the cases of fungal resistance against many antifungal drugs and an effective alternative mode in the form of immunotherapy is being considered as new hope. The adhesion of Aspergillus fumigatus conidia to the host components is one of the prime factors to cause aspergillosis. Carbohydrate components or glycoproteins present on the cell surface play an important role in interaction of the organism to the host and leads to adhesion. Any substance which is capable of disrupting this interaction may be a vital tool for the fungal clearance and hence may protect the host from infections caused by the fungus. In this study, a murine monoclonal antibody IgM generated against the secretory antigens of A. fumigatus, was found to be specific to a common epitope containing glyco-moieties of the various proteins and exhibited anti-adhesive potential in vitro.
authors.affiliation: Medical Mycology Lab, Division of Microbiology, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
authors.forename: Awanit
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Medical Mycology Lab, Division of Microbiology, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. Electronic address: pk_shukla@cdri.res.in.
authors.forename: P K
authors.initials: PK
authors.lastname: Shukla
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology* / Q000302:isolation & purification; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000302:isolation & purification; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000276:immunology* / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects*; D007075:Immunoglobulin M / Q000276:immunology / Q000302:isolation & purification; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice
chemical_list: D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D008562:Membrane Glycoproteins
keywords: Anti-adhesive; Aspergillus fumigatus; Glycoproteins; Monoclonal antibody