title: The effect of isotretinoin on retinol-binding protein 4, leptin, adiponectin and insulin resistance in acne vulgaris patients.
abstract: BACKGROUND
  The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines.
  
  
  METHODS
  Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment.
  
  
  RESULTS
  In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment.
  
  
  CONCLUSIONS
  ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Göztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
authors.forename: Zennure
authors.initials: Z
authors.lastname: Takci
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Mehmet
authors.initials: M
authors.lastname: Namuslu
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.forename: Ramazan
authors.initials: R
authors.lastname: Sekeroglu
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000287:Administration, Topical; D000293:Adolescent; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015474:Isotretinoin / Q000008:administration & dosage*; D020738:Leptin / Q000097:blood*; D008297:Male; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D003879:Dermatologic Agents; D020738:Leptin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D015474:Isotretinoin