title: Regulating the timing of CENP-A nucleosome assembly by phosphorylation.
abstract: In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that controls the timing of new CENP-A nucleosome formation at centromeres.
authors.affiliation: Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, USA.
authors.forename: Matthew D D
authors.initials: MD
authors.lastname: Miell
authors.affiliation: Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, USA. Electronic address: astraigh@stanford.edu.
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Straight
mesh_terms: D001324:Autoantigens / Q000378:metabolism*; D016203:CDC2 Protein Kinase; D002453:Cell Cycle / Q000502:physiology*; D002503:Centromere / Q000502:physiology*; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D054645:Protein Phosphatase 1 / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*
chemical_list: D001324:Autoantigens; C000619700:CENPA protein, human; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C524371:HJURP protein, human; D012694:Serine; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases; D054645:Protein Phosphatase 1