title: Controlled release of a sparingly water-soluble anticancer drug through pH-responsive functionalized gold-nanoparticle-decorated liposomes.
abstract: The binding and detachment of carboxyl-modified gold nanoparticles from liposomes is used for controlled drug delivery. This study reveals that the binding and detachment of nanoparticles from liposomes depends on the degree of hydration of the liposomes. Liposomes with a lower hydration level undergo stronger electrostatic interactions with negatively charged gold nanoparticles, thus leading to a slower detachment of the carboxyl-modified gold nanoparticles under gastric conditions. Therefore, under gastric conditions, gold-nanoparticle-decorated dipalmitoylphosphatidylcholine (DPPC) liposomes exhibit an at least ten-times-slower drug release compared to gold-nanoparticle-decorated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) liposomes, although both liposomes in the bare state fail to pursue controlled release. Our study also reveals that one can modulate the drug-release rate by simply varying the concentration of nanoparticles. This study highlights a novel strategy for the controlled release of drug molecules from liposomes.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Indore, IET, M-Block, Indore, 452017 (India).
authors.forename: Chandan
authors.initials: C
authors.lastname: Adhikari
authors.forename: Anupam
authors.initials: A
authors.lastname: Das
authors.forename: Anjan
authors.initials: A
authors.lastname: Chakraborty
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D012995:Solubility; D055672:Static Electricity; D014867:Water / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D014867:Water; D006046:Gold
keywords: controlled release; drug delivery; gold nanoparticles; hydration; liposomes