title: The role of Fatty Acid oxidation in the metabolic reprograming of activated t-cells.
abstract: Activation represents a significant bioenergetic challenge for T-cells, which must undergo metabolic reprogramming to keep pace with increased energetic demands. This review focuses on the role of fatty acid metabolism, both in vitro and in vivo, following T-cell activation. Based upon previous studies in the literature, as well as accumulating evidence in allogeneic cells, I propose a multi-step model of in vivo metabolic reprogramming. In this model, a primary determinant of metabolic phenotype is the ubiquity and duration of antigen exposure. The implications of this model, as well as the future challenges and opportunities in studying T-cell metabolism, will be discussed.
authors.affiliation: Department of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapies, University of Pittsburgh , Pittsburgh, PA , USA.
authors.forename: Craig Alan
authors.initials: CA
authors.lastname: Byersdorfer
keywords: AMP-activated protein kinase; T-cell metabolism; fatty acid oxidation; graft-versus-host disease; in vivo models; oxidative phosphorylation; reactive oxygen species (ROS)