title: [Differential concentrations of conjugated bile acids in sera of patients with polypoid lesions of gallbladder].
abstract: OBJECTIVE
  To explore the concentration differences of eight conjugated bile acids between patients of cholesterol polyps and adenomatous polyps and determine the differential diagnosis markers for polypoid lesions of gallbladder (PLG).
  
  
  METHODS
  During the period of March 2013 to November, 18 cholesterol polyps patients, 9 adenomatous polyps ones and 20 simple gallstone disease ones were enrolled. High performance liquid chromatography with ultraviolet detection was used to test 8 conjugated bile acids in sera.
  
  
  RESULTS
  A total of 8 conjugated bile acids were completely dissociated within 10 minutes and the assay was liner in the range of 3.91 to 500.00 mg/L. The correlation coefficients for linear regression were from 0.995 to 0.999 and the detection limits ranged from 3.91 to 7.81 mg/L. The serum level of glycocholic acid (GCA) in adenomatous polyps group (3.48 ± 1.66) mg/L was significantly higher than that in cholesterol polyps group ((2.16 ± 0.71) mg/L, q = 5.182, P = 0.001) and control group ((2.15 ± 0.45) mg/L, q = 5.313, P = 0.001). The serum level of glycochenodeoxycholic acid (GCDCA) in adenomatous polyps group (12.67 ± 1.74) mg/L was significantly higher than that in cholesterol polyps group ((10.53 ± 3.04) mg/L, q = 3.253, P = 0.026) and control group ((10.72 ± 1.58) mg/L, q = 3.015, P = 0.038). The serum level of taurochenodeoxycholic acid (TCDCA) in adenomatous polyps group ((6.79 ± 2.90) mg/L) was significantly higher than that in cholesterol polyps group ((4.47 ± 2.35) mg/L, q = 3.412, P = 0.020) and control group ((4.72 ± 2.11) mg/L q = 3.091, P = 0.034).
  
  
  CONCLUSIONS
  The serum levels of GCA, GCDCA and TCDCA in adenomatous polyps patients are higher than those in cholesterol polyps counterparts. And these markers may aid the differential diagnosis of PLG.
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Meifen
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Fanbin
authors.initials: F
authors.lastname: Meng
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Chunxu
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jiapeng
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pancreatic Surgery, First Hospital of China Medical University, Shenyang 110001, China. Email: gechunlin@139.com.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Ge
mesh_terms: D001647:Bile Acids and Salts; D015415:Biomarkers; D003937:Diagnosis, Differential; D005704:Gallbladder; D006801:Humans; D011127:Polyps
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers