title: Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization.
abstract: Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.
authors.affiliation: Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Theis
authors.forename: Milton L
authors.initials: ML
authors.lastname: Truong
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Coffey
authors.forename: Roman V
authors.initials: RV
authors.lastname: Shchepin
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Waddell
authors.forename: Fan
authors.initials: F
authors.lastname: Shi
authors.forename: Boyd M
authors.initials: BM
authors.lastname: Goodson
authors.forename: Warren S
authors.initials: WS
authors.lastname: Warren
authors.forename: Eduard Y
authors.initials: EY
authors.lastname: Chekmenev
mesh_terms: D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009536:Niacinamide / Q000737:chemistry*; D009587:Nitrogen Isotopes / Q000032:analysis*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D009587:Nitrogen Isotopes; D011725:Pyridines; D009536:Niacinamide; D006859:Hydrogen; C023666:pyridine