title: Genome-wide association study for posthitis in the free-living population of European bison (Bison bonasus).
abstract: BACKGROUND
  About 5-6% of the European bison (Bison bonasus) males are affected by posthitis (necrotic inflammation of the prepuce) and die in the wild forest. Despite many years of study, pathogenesis of this disease has not yet been determined. The main aim of the study was to find SNP markers significantly associated with the incidence of posthitis and mine the genome for candidate genes potentially involved in the development of the disease.
  
  
  RESULTS
  It was shown that relatively small number of SNPs effects reached genome-wide significance after false discovery rate (FDR) correction. Among 25 significant markers, the highest effects were found for two SNPs (rs110456748 and rs136792896) located at the distance of 23846 bp and 37742 bp, respectively, from OR10A3 gene (olfactory receptor genes), known to be involved in atopic dermatitis in humans. It was also observed that five other significant SNP markers were located in the proximity of candidate genes involved in severe diseases of skin tissue and cancer/tumour development of epithelial or testicular germ cells, which suggest their potential participation in the posthitis. The 25 investigated SNPs showed marked differences in allelic and genotypic frequencies between the healthy and affected bison groups.
  
  
  CONCLUSIONS
  The 2 Mb region of the BTA15 chromosome is involved in genetic background of posthitis and should be closer examined to find causal mutations helpful in better understanding of the disease ethology and to control its incidence in the future.
authors.forename: Kamil
authors.initials: K
authors.lastname: Oleński
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Tokarska
authors.forename: Dorota
authors.initials: D
authors.lastname: Hering
authors.forename: Paulina
authors.initials: P
authors.lastname: Puckowska
authors.forename: Anna
authors.initials: A
authors.lastname: Ruść
authors.forename: Cino
authors.initials: C
authors.lastname: Pertoldi
authors.forename: Stanisław
authors.initials: S
authors.lastname: Kamiński
mesh_terms: D000818:Animals; D001446:Balanitis / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D016164:Bison / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D055106:Genome-Wide Association Study; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers