title: mTOR coordinates protein synthesis, mitochondrial activity and proliferation.
abstract: Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that integrates a multitude of extracellular signals and intracellular cues to drive growth and proliferation. mTOR activity is altered in numerous pathological conditions, including metabolic syndrome and cancer. In addition to its well-established role in regulating mRNA translation, emerging studies indicate that mTOR modulates mitochondrial functions. In mammals, mTOR coordinates energy consumption by the mRNA translation machinery and mitochondrial energy production by stimulating synthesis of nucleus-encoded mitochondria-related proteins including TFAM, mitochondrial ribosomal proteins and components of complexes I and V. In this review, we highlight findings that link mTOR, mRNA translation and mitochondrial functions.
authors.affiliation: a Department of Biochemistry and Goodman Cancer Research Centre ; McGill University ; Montreal , QC Canada.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morita
authors.forename: Simon-Pierre
authors.initials: SP
authors.lastname: Gravel
authors.forename: Laura
authors.initials: L
authors.lastname: Hulea
authors.forename: Ola
authors.initials: O
authors.lastname: Larsson
authors.forename: Michael
authors.initials: M
authors.lastname: Pollak
authors.forename: Julie
authors.initials: J
authors.lastname: St-Pierre
authors.forename: Ivan
authors.initials: I
authors.lastname: Topisirovic
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000502:physiology*
chemical_list: D058570:TOR Serine-Threonine Kinases
keywords: 4E-BP1; TCA cycle; eIF4E; mRNA translation; mTOR; metabolism; mitochondria; oxidative phosphorylation