title: Percutaneous autologous pancreatic islet cell transplantation for traumatic pancreatic injury.
abstract: BACKGROUND
  Traumatic pancreatic injury with pancreatic duct disruption is surgically managed with at least a partial pancreatectomy, often leading to poor blood glucose control and the subsequent development of diabetes mellitus. Autologous β-islet cell transplantation may therefore help to preserve pancreatic endocrine function.
  
  
  METHODS
  We describe 3 patients with pancreatic duct disruption from traumatic pancreatic injury who were treated with a partial pancreatectomy followed by autologous β-islet cell transplantation via a percutaneous transhepatic approach. Immediately after trauma, 2 of the 3 patients had difficulty with glucose control that resolved after autologous β-islet cell transplantation. At follow-up, all patients remained normoglycemic.
  
  
  CONCLUSIONS
  In patients requiring partial pancreatectomy after pancreatic trauma, percutaneous transhepatic autologous β-islet cell transplantation should be considered to minimize the risk of development of diabetes mellitus.
authors.affiliation: Department of Radiology (A.S.T., B.S.S., S.G.F.H., D.M.L.) and Department of Surgery (G.L.W., M.M.), University of British Columbia, Vancouver, British Columbia V5Z 4E3, Canada.
authors.forename: Avnesh S
authors.initials: AS
authors.lastname: Thakor
authors.forename: Bippan S
authors.initials: BS
authors.lastname: Sangha
authors.forename: Stephen G F
authors.initials: SG
authors.lastname: Ho
authors.forename: Garth L
authors.initials: GL
authors.lastname: Warnock
authors.forename: Mark
authors.initials: M
authors.lastname: Meloche
authors.forename: David M
authors.initials: DM
authors.lastname: Liu
mesh_terms: D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D001265:Athletic Injuries / Q000601:surgery; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D010179:Pancreas / Q000293:injuries* / Q000601:surgery*; D010180:Pancreatectomy / Q000379:methods; D014182:Transplantation, Autologous; D014951:Wounds, Stab / Q000601:surgery