title: Pleiotropic roles in cancer biology for multifaceted proteins FKBPs.
abstract: BACKGROUND
  FK506 binding proteins (FKBP) are multifunctional proteins highly conserved across the species and abundantly expressed in the cell. In addition to a well-established role in immunosuppression, FKBPs modulate several signal transduction pathways in the cell, due to their isomerase activity and the capability to interact with other proteins, inducing changes in conformation and function of protein partners. Increasing literature data support the concept that FKBPs control cancer related pathways.
  
  
  OBJECTIVE
  The aim of the present article is to review current knowledge on FKBPs roles in regulation of key signaling pathways associated with cancer.
  
  
  CONCLUSIONS
  Some family members appear to promote disease while others are protective against tumorigenesis.
  
  
  CONCLUSIONS
  FKBPs family proteins are expected to provide new biomarkers and small molecular targets, in the near future, increasing diagnostic and therapeutic opportunities in the cancer field. This article is part of a Special Issue entitled Proline-Directed Foldases: Cell Signaling Catalysts and Drug Targets.
authors.affiliation: Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Romano
authors.affiliation: Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy; Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: D'Angelillo
authors.affiliation: Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy. Electronic address: mariafiammetta.romano@unina.it.
authors.forename: Maria Fiammetta
authors.initials: MF
authors.lastname: Romano
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D015398:Signal Transduction; D022021:Tacrolimus Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D022021:Tacrolimus Binding Proteins
keywords: Cancer; FK506 binding protein; Peptidyl-prolyl-isomerase; Tumorigenesis