title: Decreased levels of serum omentin-1 in patients with inflammatory bowel disease.
abstract: BACKGROUND
  Inflammation is involved in the mechanism of inflammatory bowel disease (IBD). Omentin, a newly discovered adipokine, is thought to play an anti-inflammatory role. This study aimed to determine whether serum levels of omentin-1 are associated with the presence and disease activity of IBD.
  
  
  METHODS
  This study consisted of 192 patients with IBD: 100 with Crohn's disease [CD], 92 with ulcerative colitis [UC], and 104 healthy subjects. Serum levels of omentin-1 were measured using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum omentin-1 levels were significantly decreased in CD and UC patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum omentin-1 levels were inversely associated with the presence of CD and UC. Active CD and UC patients both had significantly decreased levels of serum omentin-1 compared with inactive CD and UC patients. In both CD and UC patients, serum omentin-1 levels were significantly associated with decreased levels of body mass index (BMI) and C-reactive protein (CRP).
  
  
  CONCLUSIONS
  Decreased serum omentin-1 levels could be considered as an independent predicting marker of the presence and disease activity of IBD.
authors.affiliation: Department of Gastroenterology, First Affiliated to General Hospital of Chinese People's Liberation Army, Beijing, China (mainland).
authors.forename: Jian
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Gastroenterology, First Affiliated to General Hospital of Chinese People's Liberation Army, Beijing, China (mainland).
authors.forename: Peng
authors.initials: P
authors.lastname: Hou
authors.affiliation: Department of Gastroenterology, Hepatology and Feeding Disorders, First Affiliated to General Hospital of Chinese People's Liberation Army, Beijing, China (mainland).
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, First Affiliated to General Hospital of Chinese People's Liberation Army, Beijing, China (mainland).
authors.forename: Yanxiao
authors.initials: Y
authors.lastname: Nie
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood*; D003424:Crohn Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D037102:Lectins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D054392:Adipokines; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D002097:C-Reactive Protein