title: The distribution in tissues and urine of arsenic metabolites after subchronic exposure to dimethylarsinic acid (DMAV) in rats.
abstract: Dimethylarsinic acid (DMA(V)) acted as cancer promoter promoted urinary bladder, liver, and lung carcinogenesis in rats. Understanding of the distribution of arsenicals in critical sites will aid to define the action of DMA(V)-induced toxicity and carcinogenicity. The present experiment was conducted to compare the accumulated levels of arsenicals in the liver, kidney, and bladder of both male and female rats after subchronic exposure to DMA(V). After exposure to DMA(V) in drinking water for 10 weeks, urinary DMA concentrations of 100 and 200 ppm DMA(V)-treated rats increased significantly compared with those of the control rats. Smaller amount of trimethylarsinic acid (TMA) was detected in urine, but not in liver, kidney, and bladder muscle. In the liver and kidney, the levels of DMA in DMA(V)-treated rats significantly increased compared with those of the control group, but there was no difference between 100 and 200 ppm DMA(V)-treated rats. DMA did not accumulate in bladder muscle. There was no difference for DMA concentrations between male and female rats. Our results suggest that the accumulation of DMA in the liver and kidney was saturated above 100 ppm DMA(V) treatment concentration, and DMA(V) was a little partly metabolized to TMA, and TMA was rapidly excreted into urine.
authors.affiliation: Department of Environmental and Occupational Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang City, 110013, China, believeshun@163.com.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Sun
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Shuhua
authors.initials: S
authors.lastname: Xi
authors.forename: Guifan
authors.initials: G
authors.lastname: Sun
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001152:Arsenicals / Q000652:urine; D002101:Cacodylic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D017208:Rats, Wistar; D012737:Sex Factors; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000378:metabolism*
chemical_list: D001152:Arsenicals; D002101:Cacodylic Acid; C009572:trimethylarsine