title: Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides.
abstract: Root bark of Onosma echioides belonging to the family Boraginaceae is reported to be rich in naphthaquinones such as alkannins and shikonins. In this study, a dimer of alkannin/shikonin was isolated from the petroleum ether (60-80 C) extract of the bark, and the structure of the same was elucidated through spectral studies (UV, IR, NMR, MS and DEPT). The petroleum ether extract was found to contain 62.4% (w/w) of the dimer of alkannin/shikonin, and the compound is found to promote wound-healing process, when studied in the excision and incision wound models in albino rats.
authors.affiliation: a Saraswathi Vidya Bhavan's College of Pharmacy , Kalyan Shil Road, Sankaranagar, Sonarpada, Dombivli (E) 421203 Thane, Maharashtra , India.
authors.forename: Gawand
authors.initials: G
authors.lastname: Nikita
authors.forename: Purnima
authors.initials: P
authors.lastname: Vivek
authors.forename: Gadgoli
authors.initials: G
authors.lastname: Chhaya
mesh_terms: D000818:Animals; D028082:Boraginaceae / Q000737:chemistry*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009285:Naphthoquinones; D010936:Plant Extracts; C018204:alkannin; C016101:shikonin
keywords: Boraginaceae; Onosma echioides; alkannin/shikonin oligomer; excision wound; incision wound