title: Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome.
abstract: The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an apnoea-hypopnoea index (AHI) >15 h(-1). We evaluated the acute coronary syndrome severity (ejection fraction, Killip class, number of diseased vessels, and plasma peak troponin) and short-term prognosis (length of hospitalisation, complications and mortality). We included 213 patients with obstructive sleep apnoea (mean±sd AHI 30±14 h(-1), 61±10 years, 80% males) and 218 controls (AHI 6±4 h(-1), 57±12 years, 82% males). Patients with obstructive sleep apnoea exhibited a higher prevalence of systemic hypertension (55% versus 37%, p<0.001), higher body mass index (29±4 kg·m(-2) versus 26±4 kg·m(-2), p<0.001), and lower percentage of smokers (61% versus 71%, p=0.04). After adjusting for smoking, age, body mass index and hypertension, the plasma peak troponin levels were significantly elevated in the obstructive sleep apnoea group (831±908 ng·L(-1) versus 987±884 ng·L(-1), p=0.03) and higher AHI severity was associated with an increased number of diseased vessels (p=0.04). The mean length of stay in the coronary care unit was higher in the obstructive sleep apnoea group (p=0.03). This study indicates that obstructive sleep apnoea is related to an increase in the peak plasma troponin levels, number of diseased vessels, and length of stay in the coronary care unit.
authors.affiliation: Respiratory Dept, Hosp Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain febarbe.lleida.ics@gencat.cat.
authors.forename: Ferran
authors.initials: F
authors.lastname: Barbé
authors.affiliation: Respiratory Dept, Hosp Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Sánchez-de-la-Torre
authors.affiliation: Respiratory Dept, Hosp Universitari Germans Trias I Pujol, Badalona, Barcelona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Abad
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain Bio-Araba Research Institute, Araba University Hospital, Dept of Medicine of Basque Country University, Vitoria-Gasteiz, Spain.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Durán-Cantolla
authors.affiliation: Respiratory Dept, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Mediano
authors.affiliation: Respiratory Dept, Hospital Universitario Cruces, Bilbao, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Amilibia
authors.affiliation: Respiratory Dept, Hospital Parc Tauli, Sabadell, Barcelona, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Masdeu
authors.affiliation: Respiratory Dept, Hosp Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Florés
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de investigació sanitaria de Palma (IdisPa), Palma de Mallorca, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Barceló
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de investigació sanitaria de Palma (IdisPa), Palma de Mallorca, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: de la Peña
authors.affiliation: Cardiology Dept, Hospital Universitari Arnau de Vilanova, IRBLleida, Lleida, Spain.
authors.forename: Albina
authors.initials: A
authors.lastname: Aldomá
authors.affiliation: Cardiology Dept, Hospital Universitari Arnau de Vilanova, IRBLleida, Lleida, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Worner
authors.affiliation: Dept of Statistics, IRB Lleida, Lleida, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Valls
authors.affiliation: Dept of Statistics, IRB Lleida, Lleida, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Castellà
authors.affiliation: Respiratory Dept, Hosp Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sánchez-de-la-Torre
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054058:Acute Coronary Syndrome / Q000150:complications / Q000401:mortality / Q000503:physiopathology; D000886:Anthropometry; D015992:Body Mass Index; D007902:Length of Stay; D017286:Polysomnography; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000401:mortality / Q000503:physiopathology; D014336:Troponin / Q000097:blood
chemical_list: D014336:Troponin