title: Evaluation of Humoral Response and Protective Efficacy of an Inactivated Vaccine Against Peste des Petits Ruminants Virus in Goats.
abstract: Four goats were inoculated with an inactivated peste des petits ruminants virus (PPRV) vaccine. Three unvaccinated goats were kept as controls. After 36 days, the four goats were revaccinated. The immune response was monitored by virus neutralization test showing that two doses of the vaccine were able to stimulate strong immune response in all the vaccinated animals. The vaccinated goat and the controls were challenged with virulent PPRV intranasally. After PPRV challenge, the three control goats showed fever, viremia and virus excretion through mucosal surfaces, whereas the vaccinated goats were fully protected against PPRV infection and replication.
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: G M
authors.initials: GM
authors.lastname: Cosseddu
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Polci
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pinoni
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Capobianco Dondona
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Iapaolo
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Orsini
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Izzo
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bortone
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: F G
authors.initials: FG
authors.lastname: Ronchi
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Ventura
authors.affiliation: Biopharma, Rabat-Akkari, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: El Harrak
authors.affiliation: Istituto Zooprofilattico dell'Abruzzo e del Molise "G. Caporale", Teramo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Monaco
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D018107:Peste-des-petits-ruminants virus / Q000276:immunology*; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
keywords: experimental infection; goat; inactivated vaccine; peste des petits ruminants