title: Epigenetic modulation of metabolic decisions.
abstract: In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.
authors.affiliation: Department of Clinical and Experimental Medicine, Linkoping University, 58183 Linkoping, Sweden.
authors.forename: Anita
authors.initials: A
authors.lastname: Öst
authors.affiliation: Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany. Electronic address: pospisilik@ie-freiburg.mpg.de.
authors.forename: John Andrew
authors.initials: JA
authors.lastname: Pospisilik
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D050156:Adipogenesis / Q000235:genetics; D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D008660:Metabolism / Q000235:genetics*
chemical_list: D002843:Chromatin