title: Iridium(III)-catalyzed C-7 selective C-H alkynylation of indolines at room temperature.
abstract: An iridium-catalyzed direct C-7 selective C-H alkynylation of indolines at room temperature, for the first time, has been developed via C-H bond activation. Furthermore, the first example of direct C-H alkynylation of carbazoles at the C1 position is also achieved. More importantly, the resulting product can be readily transformed into C7-alkynylated indoles, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodology.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
authors.forename: Yunxiang
authors.initials: Y
authors.lastname: Wu
authors.forename: Yaxi
authors.initials: Y
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000478:Alkylation; D002227:Carbazoles / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature
chemical_list: D002227:Carbazoles; D007211:Indoles; D007495:Iridium; C057812:indoline