title: Wrinkles.
abstract: BACKGROUND
  Skin disorders associated with photodamage from ultraviolet light include wrinkles, hyperpigmentation, tactile roughness, and telangiectasia, and are more common in people with white skin compared with other skin types. Wrinkles are also associated with ageing, hormonal status, smoking, and intercurrent disease.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for skin wrinkles? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 33 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: botulinum toxin injection (e.g., botulinum toxin type A and type B), carbon dioxide laser, chemical peel (including alpha and beta hydroxyl acids), dermabrasion, isotretinoin, tazarotene, tretinoin, and variable pulse erbium:YAG laser.
authors.affiliation: Departamento de Dermatologia, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
authors.forename: Juan Jorge
authors.initials: JJ
authors.lastname: Manríquez
authors.forename: Karina
authors.initials: K
authors.lastname: Cataldo
authors.forename: Cristián
authors.initials: C
authors.lastname: Vera-Kellet
authors.forename: Isidora
authors.initials: I
authors.lastname: Harz-Fresno
mesh_terms: D003357:Cosmetic Techniques / Q000592:standards*; D006801:Humans; D015595:Skin Aging