title: Monthly microperimetry (MP1) measurement of macular sensitivity after dexamethasone implantation (Ozurdex) in retinal vein occlusions.
abstract: OBJECTIVE
  To evaluate changes in macular sensitivity as measured via microperimetry (MP) in patients with macular edema (ME) secondary to retinal vein occlusion (RVO) after dexamethasone implantation (DEX implantation, Ozurdex), in comparison to distance visual acuity, reading ability, and spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Twenty-three patients with ME secondary to RVO were treated with a DEX implantation in this prospective, observational case study. Patients were controlled at baseline and then monthly with microperimetry and assessment of distance visual acuity, reading ability, and SD- OCT. Side effects of the DEX implant were monitored by measuring the intraocular pressure (IOP) and lens grading with Lens Opacities Classification System (LOCS) charts.
  
  
  RESULTS
  The 23 patients with RVO included 16 patients with branch retinal vein occlusion (BRVO) and 7 patients with central retinal vein occlusion (CRVO). Improvement in distance visual acuity, reading ability, and in central 8-points microperimetry showed statistical significance from month 1 to 3, whereas the 40-points microperimetry improved with statistical significance from month 1 to 2. The reduction of central retinal thickness measured with SD-OCT remained statistically significant until month 4. Subgroup analysis of patients with BRVO and CRVO confirmed the best test results observed at month two after DEX implantation.
  
  
  CONCLUSIONS
  The highest macular sensitivity was measured two months after DEX implantation. This corresponds to the best test results for distance visual acuity, reading ability, and SD-OCT observed two months after treatment.
authors.affiliation: Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. sibylle.winterhalter@charite.de.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Winterhalter
authors.affiliation: Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Gerrit Alexander
authors.initials: GA
authors.lastname: Vom Brocke
authors.affiliation: Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Matthias K
authors.initials: MK
authors.lastname: Klamann
authors.affiliation: Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Bert
authors.initials: B
authors.lastname: Müller
authors.affiliation: Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Joussen
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011446:Prospective Studies; D011932:Reading; D012160:Retina / Q000502:physiology*; D012170:Retinal Vein Occlusion / Q000188:drug therapy* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Macular disease; Microperimetry; Ozurdex; Retinal vein occlusion