title: Ipilimumab in the treatment of prostate cancer.
abstract: Ipilimumab (Yervoy(®); Bristol-Myers Squibb, NY, USA) is a fully human monoclonal antibody targeting CTLA-4 and is approved for the treatment of metastatic melanoma. Preclinical and clinical studies have shown its activity in a number of different cancer types, including prostate cancer. Recently, the results from a Phase III study of ipilimumab in prostate cancer patients with prior docetaxel therapy were reported. Although the study did not meet the primary end point of improved overall survival, prespecified subset analyses suggested that ipilimumab may be more active in men with lower disease burden, which suggests that immunotherapy should be tested early in men with castration-refractory prostate cancer. Immune-related adverse events are common and most can be well managed with standard immunosuppressive algorithms.
authors.affiliation: Division of Medical Oncology, Department of Medicine, University of Utah Huntsman Cancer Institute, 2000 Circle of Hope, Ste 2123, Salt Lake City, UT 84112, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Reese
authors.forename: Ali
authors.initials: A
authors.lastname: Straubhar
authors.forename: Sumanta K
authors.initials: SK
authors.lastname: Pal
authors.forename: Neeraj
authors.initials: N
authors.lastname: Agarwal
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000954:Antigens, Surface / Q000276:immunology / Q000627:therapeutic use; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology / Q000627:therapeutic use; D060908:CTLA-4 Antigen / Q000276:immunology / Q000627:therapeutic use; D000077143:Docetaxel; D043425:Glutamate Carboxypeptidase II / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D000074324:Ipilimumab; D008297:Male; D011471:Prostatic Neoplasms / Q000276:immunology / Q000628:therapy*; D043823:Taxoids / Q000008:administration & dosage; D014020:Tissue Extracts / Q000008:administration & dosage*
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015295:Antigens, Tumor-Associated, Carbohydrate; D060908:CTLA-4 Antigen; D000074324:Ipilimumab; D043823:Taxoids; D014020:Tissue Extracts; D000077143:Docetaxel; C511774:sipuleucel-T; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II
keywords: CTLA-4; immunotherapy; ipilimumab; prostate cancer