title: HIV-1/HIV-2 versus SAMHD1 restriction: a tale of two viruses.
abstract: The deoxynucleoside triphosphate triphosphohydrolase SAMHD1 is a myeloid cell-specific retroviral restriction factor that can be inactivated by viral protein Vpx from HIV-2 and certain SIV. In this issue of Cell Host & Microbe, Kyei et al. (2015) report that cyclin L2 enhances HIV-1 infection in macrophages by regulating SAMHD1.
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: xfyu@tju.edu.cn.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Yu
mesh_terms: D016213:Cyclins / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008264:Macrophages / Q000821:virology*; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D016213:Cyclins; D014157:Transcription Factors; D020559:Monomeric GTP-Binding Proteins