title: In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung.
abstract: Despite the promising potential of microfluidic artificial lungs, current designs suffer from short functional lifetimes due to surface chemistry and blood flow patterns that act to reduce hemocompatibility. Here, we present the first microfluidic artificial lung featuring a hemocompatible surface coating and a biomimetic blood path. The polyethylene-glycol (PEG) coated microfluidic lung exhibited a significantly improved in vitro lifetime compared to uncoated controls as well as consistent and significantly improved gas exchange over the entire testing period. Enabled by our hemocompatible PEG coating, we additionally describe the first extended (3 h) in vivo demonstration of a microfluidic artificial lung.
authors.affiliation: Advanced Platform Technology Center (APT Center), Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Kovach
authors.forename: M A
authors.initials: MA
authors.lastname: LaBarbera
authors.forename: M C
authors.initials: MC
authors.lastname: Moyer
authors.forename: B L
authors.initials: BL
authors.lastname: Cmolik
authors.forename: E
authors.initials: E
authors.lastname: van Lunteren
authors.forename: A
authors.initials: A
authors.lastname: Sen Gupta
authors.forename: J R
authors.initials: JR
authors.lastname: Capadona
authors.forename: J A
authors.initials: JA
authors.lastname: Potkay
mesh_terms: D000818:Animals; D001187:Artificial Organs; D032701:Biomimetics / Q000295:instrumentation; D004867:Equipment Design; D008168:Lung / Q000098:blood supply*; D008297:Male; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D033081:Shear Strength; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D012822:Silicon Dioxide