title: Correlation between serum RANTES levels and the severity of Parkinson's disease.
abstract: Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Tang
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chong
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Hou
authors.affiliation: Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No. 256 Youyi Road, Xi'an 710068, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
mesh_terms: D000368:Aged; D018946:Chemokine CCL5 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000097:blood* / Q000473:pathology*
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5