title: Tumor site and disease stage as predictors of quality of life in head and neck cancer: a prospective study on patients treated with surgery or combined therapy with surgery and radiotherapy or radiochemotherapy.
abstract: In this prospective study, we compared the short-term quality of life (QOL) of two subgroups of head and neck cancers: oropharyngeal and laryngeal cancers. Patients treated with curative surgery, were asked to participate in the study using the EORTC QLQ-C30 and H&N35 questionnaires to examine QOL. The oropharynx group consisted of 32 (48 %) patients, while the larynx group consisted of 35 (52 %) patients. All patients were treated with either curative surgery alone or curative surgery combined with adjuvant radiotherapy or radiochemotherapy. The questionnaires were handed out pre- and post-therapy (10 months). At baseline, an impaired overall QOL (=EORTC QLQ-C30 global score) with a value of 53.4 for the whole patient collective was found; the overall QOL after 10 months improved (60.2, p < 0.05). Between the two patient groups, there was no difference in the global score after 10 months. The oropharynx patients described more problems with fatigue and oral cavity associated. The main symptoms in the larynx group were loss of sensual function and coughing. The present investigation revealed that the general post-therapy QOL in two subgroups of head and neck cancer reached a satisfying level.
authors.affiliation: Department of Internal Medicine, Ruhr-University Bochum, St. Josef Hospital, Bochum, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Veldhuis
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr-University Bochum, St. Elisabeth Hospital, Bleichstr. 15, 44787, Bochum, Germany.
authors.forename: Gunther
authors.initials: G
authors.lastname: Probst
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr-University Bochum, St. Elisabeth Hospital, Bleichstr. 15, 44787, Bochum, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Marek
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr-University Bochum, St. Elisabeth Hospital, Bleichstr. 15, 44787, Bochum, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Noack
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ural
authors.affiliation: Department of Radiation Oncology, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Irenaeus
authors.initials: I
authors.lastname: Adamietz
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr-University Bochum, St. Elisabeth Hospital, Bleichstr. 15, 44787, Bochum, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Dazert
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ruhr-University Bochum, St. Elisabeth Hospital, Bleichstr. 15, 44787, Bochum, Germany. amir.minovi@rub.de.
authors.forename: Amir
authors.initials: A
authors.lastname: Minovi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000523:psychology / Q000628:therapy; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000379:methods; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005858:Germany; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000523:psychology / Q000628:therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000523:psychology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000009:adverse effects / Q000379:methods; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000523:psychology / Q000628:therapy; D011183:Postoperative Complications / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014421:Turkey
keywords: Cancer; Head and Neck; Larynx; Oropharynx; Quality of life