title: SnapShot: Fanconi anemia and associated proteins.
abstract: Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved.
authors.affiliation: Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Anderson T
authors.initials: AT
authors.lastname: Wang
authors.affiliation: Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Agata
authors.initials: A
authors.lastname: Smogorzewska
mesh_terms: D000818:Animals; D004260:DNA Repair; D005199:Fanconi Anemia / Q000378:metabolism*; D051856:Fanconi Anemia Complementation Group Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D051856:Fanconi Anemia Complementation Group Proteins