title: Association of body mass index with embryonic aneuploidy.
abstract: OBJECTIVE
  To determine whether an association exists between body mass index (BMI) and embryo ploidy in patients undergoing in vitro fertilization (IVF) with trophectoderm biopsy and 24-chromosome preimplantation genetic screening (PGS).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based fertility center.
  
  
  METHODS
  279 women aged 20-45 years with documented height and weight from the day of oocyte retrieval who underwent 24-chromosome PGS between 2010 and 2013.
  
  
  METHODS
  None.
  
  
  METHODS
  
  
  
  METHODS
  number and percentage of euploid embryos.
  
  
  RESULTS
  Patients were grouped by World Health Organization (WHO) BMI class: underweight (<18.5, n = 11), normal weight (18.5-24.9, n = 196), overweight (25-29.9, n = 50), and obese (≥30, n = 22). Groups were similar by age (mean ± standard error of the mean: 37.5 ± 1.2 to 39.2 ± 0.9), ovarian reserve, and IVF cycle parameters. There was no difference in the number or percentage of euploid embryos by BMI category (<18.5: 27.6% ± 8.5; 18.5-24.9: 34.5% ± 2.2; 25-29.9: 32.1% ± 4.3; ≥30: 30.9% ± 7.3). Age was inversely related to euploidy, but adjusted multivariate regression models failed to demonstrate a statistically significant relationship between BMI and euploidy in underweight (adjusted odds ratio [AOR] 0.44; 95% confidence interval [CI], 0.09-2.10), overweight (AOR 0.90; 95% CI, 0.43-2.00), or obese (AOR 0.74; 95% CI, 0.25-2.20) patients compared with the normal-weight reference group.
  
  
  CONCLUSIONS
  No statistically significant relationship was identified between BMI and euploidy in an otherwise homogenous cohort of patients undergoing IVF with PGS, suggesting that the negative impact of overweight and obesity on IVF and reproductive outcomes may not be related to aneuploidy.
authors.affiliation: New York University Fertility Center, New York University Langone Medical Center, New York, New York. Electronic address: kara.goldman@med.nyu.edu.
authors.forename: Kara N
authors.initials: KN
authors.lastname: Goldman
authors.affiliation: New York University Fertility Center, New York University Langone Medical Center, New York, New York.
authors.forename: Brooke
authors.initials: B
authors.lastname: Hodes-Wertz
authors.affiliation: New York University Fertility Center, New York University Langone Medical Center, New York, New York.
authors.forename: David H
authors.initials: DH
authors.lastname: McCulloh
authors.affiliation: New York University Fertility Center, New York University Langone Medical Center, New York, New York.
authors.forename: Julie D
authors.initials: JD
authors.lastname: Flom
authors.affiliation: New York University Fertility Center, New York University Langone Medical Center, New York, New York.
authors.forename: Jamie A
authors.initials: JA
authors.lastname: Grifo
mesh_terms: D000328:Adult; D000782:Aneuploidy; D015992:Body Mass Index; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis / Q000706:statistics & numerical data; D012189:Retrospective Studies; D055815:Young Adult
keywords: 24-chromosome preimplantation genetic screening; Aneuploidy; body mass index (BMI); obesity