title: A multichannel current stimulator chip for spatiotemporal pattern stimulation of neural tissues.
abstract: We developed a prototype very-large-scale integration chip of a multichannel current stimulator for stimulating neural tissues by utilizing 0.25 μm high-voltage complementary metal-oxide-semiconductor technology. Our designed chip has 20 output channels that are driven by five current buffers arranged in parallel; each buffer controls four output channels in time-sharing mode. The amplitude of a stimulation pulse can be controlled within a range of approximately ±100 μA/phase in each output channel. The stimulus parameters, e.g., amplitude and duration, are controlled separately for each channel by digital codes stored in built-in registers. Combinations of anode and cathode electrodes to pass the current can be changed online. We integrated our stimulator chip with a multielectrode array and studied the neuronal responses to multichannel current stimulations with various temporal patterns in mouse brain slices.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kameda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Yuta
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Dai
authors.initials: D
authors.lastname: Akita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yagi
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D002021:Buffers; D054022:Cerebrum / Q000502:physiology; D004566:Electrodes; D004867:Equipment Design; D008670:Metals / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009417:Nerve Tissue / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010087:Oxides / Q000737:chemistry; D012666:Semiconductors; D062211:Spatio-Temporal Analysis; D014793:Visual Cortex / Q000502:physiology
chemical_list: D002021:Buffers; D008670:Metals; D010087:Oxides