title: Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors.
abstract: Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. yo-hi@fujita-hu.ac.jp.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Japan. yakao@gifu-u.ac.jp.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.affiliation: The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Japan. sur144@poh.osaka-med.ac.jp.
authors.forename: Kohei
authors.initials: K
authors.lastname: Taniguchi
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. akemie80_82@yahoo.co.jp.
authors.forename: Akemi
authors.initials: A
authors.lastname: Kamatani
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. ttahara@fujita-hu.ac.jp.
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. tkamano@fujita-hu.ac.jp.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kamano
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. naokomaruyama-gi@umin.ac.jp.
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakano
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. n-kom@hotmail.co.jp.
authors.forename: Naruomi
authors.initials: N
authors.lastname: Komura
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. h-ikuno@fujita-hu.ac.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ikuno
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. takafumi@fujita-hu.ac.jp.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ohmori
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. 2080319yj@gmail.com.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Jodai
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. qqur5wd9k@comet.ocn.ne.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miyata
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. nmitsu@fujita-hu.ac.jp.
authors.forename: Mistuo
authors.initials: M
authors.lastname: Nagasaka
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. shibat03@fujita-hu.ac.jp.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. nohmiya@fujita-hu.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.affiliation: Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan. ihirata@fujita-hu.ac.jp.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology*; D015536:Down-Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009367:Neoplasm Staging; D015854:Up-Regulation
chemical_list: D035683:MicroRNAs