title: Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents.
abstract: Investigation of new X-ray contrast media for radiography is an important field of science since discovering of X-rays in 1895. Despite the wide diversity of available X-ray contrast media the toxicity, especially nephrotoxicity, is still a big problem to be solved. The octahedral metal-cluster complexes of the general formula [{M6Q8}L6] can be considered as quite promising candidates for the role of new radiocontrast media due to the high local concentration of heavy elements, high tuning ability of ligand environment and low toxicity. To exemplify this, the X-ray computed tomography experiments for the first time were carried out on some octahedral cluster complexes of molybdenum and rhenium. Based on the obtained data it was proposed to investigate the toxicological proprieties of cluster complex Na2H8[{Re6Se8}(P(CH2CH2CONH2)(CH2CH2COO)2)6]. Observed low cytotoxic and acute toxic effects along with rapid renal excretion of the cluster complex evidence its perspective as an X-ray contrast media for radiography.
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation.
authors.forename: Anna A
authors.initials: AA
authors.lastname: Krasilnikova
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation; Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova Str., Novosibirsk 630060, Russian Federation. Electronic address: shtopy@niic.nsc.ru.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Shestopalov
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation.
authors.forename: Konstantin A
authors.initials: KA
authors.lastname: Brylev
authors.affiliation: Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, 17 Frunze Str., Novosibirsk 630091, Russian Federation.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Kirilova
authors.affiliation: The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation.
authors.forename: Olga P
authors.initials: OP
authors.lastname: Khripko
authors.affiliation: Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova Str., Novosibirsk 630060, Russian Federation; The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation.
authors.forename: Kristina E
authors.initials: KE
authors.lastname: Zubareva
authors.affiliation: The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation.
authors.forename: Yuri I
authors.initials: YI
authors.lastname: Khripko
authors.affiliation: Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, 17 Frunze Str., Novosibirsk 630091, Russian Federation.
authors.forename: Valentina T
authors.initials: VT
authors.lastname: Podorognaya
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation.
authors.forename: Lidiya V
authors.initials: LV
authors.lastname: Shestopalova
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation.
authors.forename: Vladimir E
authors.initials: VE
authors.lastname: Fedorov
authors.affiliation: Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Mironov
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D056831:Coordination Complexes / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D008982:Molybdenum; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology; D065667:Renal Elimination; D012211:Rhenium; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D012211:Rhenium; D008982:Molybdenum
keywords: Octahedral metal clusters; X-ray computed tomography; X-ray contrast media