title: Turning telomerase into a Jekyll and Hyde case?
abstract: It may be possible to coerce telomerase to incorporate modified guanine nucleotides into telomeric repeat DNA, thereby seriously compromising the functionality of the telomeres. Thus, a guanine analogue such as 6-thio-dG could turn active telomerase into a chromosome de-protecting enzyme, the opposite of what it is normally, namely a chromosome-protecting enzyme.
authors.affiliation: Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Raymund.Wellinger@USherbrooke.ca.
authors.forename: Raymund J
authors.initials: RJ
authors.lastname: Wellinger
mesh_terms: D000818:Animals; D003849:Deoxyguanosine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*; D013872:Thionucleosides / Q000494:pharmacology*
chemical_list: D013872:Thionucleosides; D019098:Telomerase; D003849:Deoxyguanosine