title: Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment?
abstract: OBJECTIVE
  The aim of this article is to assess whether near-infrared spectroscopy (NIRS) identifies, during hypothermia treatment, the asphyxiated newborns who later develop brain injury.
  
  
  METHODS
  In this study, asphyxiated newborns, for whom later brain injury was defined by brain imaging and/or autopsy results, were monitored by NIRS during therapeutic hypothermia. We compared regional cerebral oxygenation saturation (rSO2) measured by NIRS at key time points for newborns who developed or did not develop later brain injury.
  
  
  RESULTS
  A total of 18 asphyxiated newborns treated with hypothermia were enrolled. rSO2 was higher in the asphyxiated newborns who developed later brain injury. Sensitivity within the first 10 hours of hypothermia treatment for an adverse outcome was 100% (95% confidence interval [CI], 70-100%) and specificity was 83% (95% CI, 36-99%).
  
  
  CONCLUSIONS
  NIRS appears to identify asphyxiated newborns at risk of developing brain injury as early as the first 10 hours of hypothermia treatment. Thus, NIRS may have an important role as an early outcome predictor in this population.
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
authors.forename: Shuo
authors.initials: S
authors.lastname: Peng
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
authors.forename: Elodie
authors.initials: E
authors.lastname: Boudes
authors.affiliation: Biostatistics Core Facility, Research Institute, McGill University Health Centre, Montreal, Canada.
authors.forename: Xianming
authors.initials: X
authors.lastname: Tan
authors.affiliation: Department of Radiology, Montreal Children's Hospital, McGill University, Montreal, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Saint-Martin
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Shevell
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
authors.forename: Pia
authors.initials: P
authors.lastname: Wintermark
mesh_terms: D001238:Asphyxia Neonatorum / Q000628:therapy*; D001921:Brain / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008991:Monitoring, Physiologic; D010101:Oxygen Consumption; D011379:Prognosis; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared