title: Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activity.
abstract: Nanocomposite materials are gaining grounds in the fields of medicine, environmental sciences and for basic studies. Herein, we have developed, a novel method for the preparation of chitosan-g-poly(acrylamide)/ZnS (abbreviated as CPAZ) nanocomposite using microwave radiations. The synthesized CPAZ nanocomposites were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and thermo gravimetric analysis (TGA). FTIR results established the grafting of acrylamide onto chitosan backbone. TEM analysis revealed the size of the CPAZ nanocomposite particles in the range of 19-26 nm. XRD technique predicated the crystalline behavior of the nanocomposite. Therefore, XRD, TEM and FTIR spectrum analysis confirmed the formation of CPAZ nanocomposites. Zeta potential for CPAZ nanocomposite was found to be +28.2 mV which indicated its stability. The CPAZ nanocomposites were investigated for drug release behavior and we found a maximum of 79% drug release at pH 2.2. Moreover, CPAZ nanocomposite was also found to be antimicrobial against Escherichia coli bacteria.
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India.
authors.forename: Divya
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Faculty of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India.
authors.forename: Devender
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Chemistry, National Institute of Technology, Jalandhar 144011, Punjab, India.
authors.forename: N C
authors.initials: NC
authors.lastname: Kothiyal
authors.affiliation: Faculty of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India.
authors.forename: Adesh K
authors.initials: AK
authors.lastname: Saini
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India.
authors.forename: Virender Partap
authors.initials: VP
authors.lastname: Singh
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P., India. Electronic address: dpathania74@gmail.com.
authors.forename: Deepak
authors.initials: D
authors.lastname: Pathania
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D016466:CHO Cells; D048271:Chitosan / Q000737:chemistry*; D006224:Cricetinae; D003412:Cricetulus; D016503:Drug Delivery Systems; D065546:Drug Liberation; D008872:Microwaves; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D015242:Ofloxacin / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000737:chemistry*; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D017967:Zinc Compounds / Q000737:chemistry*; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D048271:Chitosan; D015242:Ofloxacin; D013440:Sulfides; D017967:Zinc Compounds; D000099166:Polyacrylamides; C031238:zinc sulfide
keywords: Antimicrobial; Chitosan; Drug delivery; E. coli; Grafting; Nanocomposite