title: Cerebroprotective and regenerative effects of alkaloid Z77 under conditions of brain ischemia.
abstract: We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of cerebral ischemia. Pronounced cerebroprotective effect was found consisting in normalization of the orienting and exploratory activity and conditioned behavior associated with significant correction of morphological changes in the brain. The direct stimulatory effect of Z77 on neural stem cells was shown in vitro.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: E A
authors.initials: EA
authors.lastname: Losev
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: V P
authors.initials: VP
authors.lastname: Demkin
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D008297:Male; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D044968:Regenerative Medicine / Q000379:methods
chemical_list: D000470:Alkaloids; D018696:Neuroprotective Agents