title: Preoperative apparent diffusion coefficient value of gastric cancer by diffusion-weighted imaging: Correlations with postoperative TNM staging.
abstract: BACKGROUND
  To determine if the apparent diffusion coefficient (ADC) values of gastric cancers on the preoperative diffusion weighted imaging (DWI) correlate with the postoperative TNMs of the lesions.
  
  
  METHODS
  In a retrospective clinical study, seventy patients with gastric cancers were enrolled and each underwent a MRI before surgery. DWI was obtained with a single-shot, echo-planar imaging sequence in the axial plane (b values: 0 and 1000 s/mm(2) ). The mean and minimum ADC values of the gastric cancers were calculated and compared among various postoperative TNM staging.
  
  
  RESULTS
  Both mean and minimum ADC values of the gastric cancers correlated with the postoperative T staging (r = -0.464, -0.476; both P < 0.001), N staging (r = -0.402, -0.397; P = 0.001, 0.002) and TNM staging (r = -0.446, -0.437; both P < 0.001). The areas under the receiver operating characteristic (ROC) curves for the differentiating lymph node metastasis were 0.788 for the mean ADC values (P = 0.001) and 0.778 for the minimum ADC values (P = 0.001).
  
  
  CONCLUSIONS
  The preoperative ADC values of gastric cancers can help to assess the postoperative TNM staging.
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Wenxian
authors.initials: W
authors.lastname: Guan
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Zhuping
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Yu
authors.affiliation: Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.affiliation: Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Zhengyang
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D057234:Preoperative Period; D012372:ROC Curve; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology*
keywords: diagnosis; diffusion magnetic resonance imaging; lymphatic metastasis; neoplasm staging; stomach neoplasms