title: Novel method for rapid reversal of drug toxicity: a case report.
abstract: Drug toxicity is traditionally treated by reducing the amount of the drug absorbed, enhancing elimination, and providing supportive care. Once the drug has been absorbed, there are few methods that help decrease morbidity and mortality caused by a toxic drug level. Albumin infusion is a new approach that changes that, as it can rapidly reverse a toxic drug level back to a therapeutic level. It is believed with most drugs that the toxic effects are related to the total amount of the free drug. In this method, albumin binds to the free drug and acts as a reservoir or depot from which the drug is slowly released to the free form, thereby limiting the effects of drug toxicity. In this case report, an elderly female patient who experienced phenytoin toxicity was treated with albumin infusion, after which her phenytoin level returned to a therapeutic level with corresponding improvements in her symptoms. Based on our calculations, it was predicted that a small amount of albumin would reverse the patient's toxic symptoms. With this approach, the patient's toxic symptoms improved when free phenytoin levels dropped from 15 to 8 μmol/L. Albumin infusion is a promising new therapy that can rapidly reverse a toxic drug level back to a therapeutic level by binding the free drug to albumin.
authors.affiliation: Alberta Health Services, Calgary, AB, Canada.
authors.forename: Dean
authors.initials: D
authors.lastname: Tatlow
authors.forename: Sreeja
authors.initials: S
authors.lastname: Poothencheri
authors.forename: Ranjit
authors.initials: R
authors.lastname: Bhangal
authors.forename: Corinne
authors.initials: C
authors.lastname: Tatlow
mesh_terms: D000369:Aged, 80 and over; D000418:Albumins / Q000008:administration & dosage* / Q000378:metabolism; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008954:Models, Biological; D010672:Phenytoin / Q000097:blood / Q000506:poisoning*; D011041:Poisoning / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D011485:Protein Binding; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000418:Albumins; D000927:Anticonvulsants; D010672:Phenytoin
keywords: chemotherapy; drug toxicity; phenytoin; treatment