title: Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep.
abstract: OBJECTIVE
  Electroencephalographic recovery is predictive of outcome after perinatal hypoxia-ischemia, but it is unknown whether early changes in electroencephalographic can predict the response to therapeutic hypothermia in the preterm brain.
  
  
  METHODS
  0.7 gestation fetal sheep received umbilical cord occlusion or sham occlusion for 25 minutes, followed by sham hypothermia or whole-body cooling started either 30 minutes or 5 hours after occlusion and continued for 72 hours.
  
  
  RESULTS
  Early but not delayed hypothermia reduced neuronal loss and microglial induction in the striatum, with faster recovery of spectral edge frequency, reduced seizure burden, and less suppression of electroencephalographic amplitude (P<0.05).
  
  
  CONCLUSIONS
  Recovery of higher electroencephalographic frequencies may be a biomarker of effective hypothermic neuroprotection in the preterm-equivalent brain.
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Guido
authors.initials: G
authors.lastname: Wassink
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Barrett
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Joanne O
authors.initials: JO
authors.lastname: Davidson
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Laura
authors.initials: L
authors.lastname: Bennet
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Robert
authors.initials: R
authors.lastname: Galinsky
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand.
authors.forename: Michael
authors.initials: M
authors.lastname: Dragunow
authors.affiliation: From the Department of Physiology (G.W., R.D.B., J.O.D., L.B., R.G., A.J.G.), and Department of Anatomy with Radiology (M.D.), University of Auckland, Auckland, New Zealand. aj.gunn@auckland.ac.nz.
authors.forename: Alistair J
authors.initials: AJ
authors.lastname: Gunn
mesh_terms: D000818:Animals; D001237:Asphyxia / Q000503:physiopathology* / Q000628:therapy*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005333:Fetus; D007036:Hypothermia, Induced / Q000379:methods*; D011247:Pregnancy; D011897:Random Allocation; D020127:Recovery of Function; D012756:Sheep
keywords: EEG; hypothermia