title: Blood reflects tissue oxidative stress: a systematic review.
abstract: We examined whether the levels of oxidative stress biomarkers measured in blood reflect the tissue redox status. Data from studies that measured redox biomarkers in blood, heart, liver, kidney and skeletal muscle were analyzed. In seven out of nine investigated redox biomarkers (malondialdehyde, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, vitamin C and E) there was generally good qualitative and quantitative agreement between the blood and tissues. In contrast, oxidized glutathione and the reduced to oxidized glutathione ratio showed poor agreement between the blood and tissues. This study suggests that most redox biomarkers measured in blood adequately reflect tissue redox status.
authors.affiliation: School of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki , Serres , Greece .
authors.forename: Nikos V
authors.initials: NV
authors.lastname: Margaritelis
authors.forename: Aristidis S
authors.initials: AS
authors.lastname: Veskoukis
authors.forename: Vassilis
authors.initials: V
authors.lastname: Paschalis
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vrabas
authors.forename: Konstantina
authors.initials: K
authors.lastname: Dipla
authors.forename: Andreas
authors.initials: A
authors.lastname: Zafeiridis
authors.forename: Antonios
authors.initials: A
authors.lastname: Kyparos
authors.forename: Michalis G
authors.initials: MG
authors.lastname: Nikolaidis
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013045:Species Specificity
chemical_list: D015415:Biomarkers
keywords: Antioxidant; biomarkers; blood; muscle; oxidative stress; tissues