title: Assessment of lung function by spirometry and diffusion study and effect of glycemic control on pulmonary function in type 2 diabetes mellitus patients of the eastern India.
abstract: BACKGROUND
  There are so many complications involving eyes, kidneys, lungs and nerves associated with diabetes. But, pulmonary complications are poorly characterized among eastern Indian diabetic populations.
  
  
  OBJECTIVE
  To assess pulmonary function in patients with type 2 diabetes mellitus. To find out correlation of the pulmonary functions test variables with Glycemic control.
  
  
  METHODS
  Total of 60 type 2 diabetes patient of age between 35-55 y and same number of age and sex matched apparently healthy control individual were included in the present study. All subjects were evaluated for PFT by flow sensitive spirometer (RMS HELIOS-401), the spirometric parameters were measured as a percentage of predicted and DLCO (by single breath technique). HBA1c of all cases were measured and they were grouped according to HBA1c level (Group-a =>7%, Group-b =6%-7%, Group-c =<6%).
  
  
  RESULTS
  Significant differences in the spirometric parameters (FVC, FEV1/FVC) and diffusion capacity (DLCO% and DL/VA%) existed between cases and controls. There was a significant decrease in FVC, DLCO and DL/VA and significant increase in FEV1/FVC in that groups having HBA1c level >7% than the other groups. FEV1, FVC, DLCO, and DL/VA were negatively correlated with HbA1c where as FEV1/FVC has positive association with HbA1c.
  
  
  CONCLUSIONS
  Significant deterioration of lung function and diffusing capacity was observed in type 2 diabetes patients with poor glycemic control.
authors.affiliation: Assistant Professor, Department of Physiology, Murshidabad Medical College , Berhampore, India .
authors.forename: Salim
authors.initials: S
authors.lastname: Uz-Zaman
authors.affiliation: Assistant Professor, Department of Physiology, RGKar Medical College , Kolkata, India .
authors.forename: Joyashree
authors.initials: J
authors.lastname: Banerjee
authors.affiliation: Professor and Head, Department of Physiology, RGKar Medical College , Kolkata, India .
authors.forename: Anilbaran
authors.initials: A
authors.lastname: Singhamahapatra
authors.affiliation: Assistant Professor, Department of Paediatrics Midnapur Medical College , Midnapur, India .
authors.forename: Pranab Kumar
authors.initials: PK
authors.lastname: Dey
authors.affiliation: Assistant Professor, Department of Physiology, RGKar Medical College , Kolkata, India .
authors.forename: Anindya
authors.initials: A
authors.lastname: Roy
authors.affiliation: Junior Resident, Department of Physiology, RGKar Medical College , Kolkata, India .
authors.forename: Kaushik
authors.initials: K
authors.lastname: Roy
authors.affiliation: Professor and Head, Department of Physiology, Malda Medical College , Malda, India .
authors.forename: Kakali
authors.initials: K
authors.lastname: Roy Basu
keywords: Glycemic control; Pulmonary function test; Type-2 diabetes mellitus