title: Collagen gel formation in the presence of a carbon nanobrush.
abstract: Type I, bovine skin collagen was allowed to gel in the presence of various concentrations of a carbon nanotube material covered with a polystyrene/polyaniline copolymer, called a carbon nanobrush (CNB). The rate of collagen gelation was enhanced by the presence of the CNB in a dose dependent manner. The extent of collagen gelation was due to the concentration of collagen and not the amount of CNB. Collagen D-periodicity, and average fibril diameter were unchanged by the CNB material as seen in transmission electron micrographs. Gel tensile strength was reduced by the presence of the CNB in a dose related manner. The collagen-CNB mixture may have a role in the repair and reconstruction of wounds or degenerated connective tissue.
authors.affiliation: Department of Chemistry, University of Rhode Island, Kingston, RI, 02881, USA, gDombi@chm.uri.edu.
authors.forename: George W
authors.initials: GW
authors.lastname: Dombi
authors.forename: Kaushalkumar
authors.initials: K
authors.lastname: Purohit
authors.forename: Lenore M
authors.initials: LM
authors.lastname: Martin
authors.forename: Sze C
authors.initials: SC
authors.lastname: Yang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002417:Cattle; D003094:Collagen / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005782:Gels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012867:Skin / Q000473:pathology; D013314:Stress, Mechanical; D013718:Tensile Strength; D014945:Wound Healing
chemical_list: D000814:Aniline Compounds; D001672:Biocompatible Materials; D005782:Gels; D037742:Nanotubes, Carbon; D011108:Polymers; D011137:Polystyrenes; C416807:polyaniline; D003094:Collagen