title: Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): study protocol for a randomized controlled trial.
abstract: BACKGROUND
  Older adults who have received inpatient rehabilitation often have significant mobility disability at discharge. Physical activity levels in rehabilitation are also low. It is hypothesized that providing increased physical activity to older people receiving hospital-based rehabilitation will lead to better mobility outcomes at discharge.
  
  
  METHODS
  A single blind, parallel-group, multisite randomized controlled trial with blinded assessment of outcome and intention-to-treat analysis. The cost effectiveness of the intervention will also be examined. Older people (age >60 years) undergoing inpatient rehabilitation to improve mobility will be recruited from geriatric rehabilitation units at two Australian hospitals. A computer-generated blocked stratified randomization sequence will be used to assign 198 participants in a 1:1 ratio to either an 'enhanced physical activity' (intervention) group or a 'usual care plus' (control) group for the duration of their inpatient stay. Participants will receive usual care and either spend time each week performing additional physical activities such as standing or walking (intervention group) or performing an equal amount of social activities that have minimal impact on mobility such as card and board games (control group). Self-selected gait speed will be measured using a 6-meter walk test at discharge (primary outcome) and 6 months follow-up (secondary outcome). The study is powered to detect a 0.1 m/sec increase in self-selected gait speed in the intervention group at discharge. Additional measures of mobility (Timed Up and Go, De Morton Mobility Index), function (Functional Independence Measure) and quality of life will be obtained as secondary outcomes at discharge and tertiary outcomes at 6 months follow-up. The trial commenced recruitment on 28 January 2014.
  
  
  CONCLUSIONS
  This study will evaluate the efficacy and cost effectiveness of increasing physical activity in older people during inpatient rehabilitation. These results will assist in the development of evidenced-based rehabilitation programs for this population.
  
  
  BACKGROUND
  Australian New Zealand Clinical Trials Registry ACTRN12613000884707 (Date of registration 08 August 2013); ClinicalTrials.gov Identifier NCT01910740 (Date of registration 22 July 2013).
authors.affiliation: Department of Physiotherapy, School of Allied Health, La Trobe University, Kingsbury Drive, Bundoora, Victoria, 3086, Australia. Cathy.SAID@austin.org.au.|Department of Physiotherapy, Austin Health, 145 Studley Rd, Heidelberg, Victoria, 3084, Australia. Cathy.SAID@austin.org.au.|Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. Cathy.SAID@austin.org.au.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Said
authors.affiliation: Department of Physiotherapy, School of Allied Health, La Trobe University, Kingsbury Drive, Bundoora, Victoria, 3086, Australia. M.Morris@latrobe.edu.au.
authors.forename: Meg E
authors.initials: ME
authors.lastname: Morris
authors.affiliation: Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. mcginley@unimelb.edu.au.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McGinley
authors.affiliation: Department of Psychiatry & National Ageing Research Institute, The University of Melbourne, Parkville, Victoria, 3050, Australia. cszoeke@unimelb.edu.au.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Szoeke
authors.affiliation: Rehabilitation and Aged Services, Monash Health, Warrigal Rd, Cheltenham, Victoria, 3192, Australia. Barbara.Workman@monashhealth.org.|Monash Ageing Research Centre (MONARC), Monash University, Warrigal Rd, Cheltenham, Victoria, 3192, Australia. Barbara.Workman@monashhealth.org.
authors.forename: Barbara
authors.initials: B
authors.lastname: Workman
authors.affiliation: Melbourne EpiCentre, The University of Melbourne and Melbourne Health, Parkville, Victoria, 3050, Australia. Danny.Liew@mh.org.au.
authors.forename: Danny
authors.initials: D
authors.lastname: Liew
authors.affiliation: School of Physiotherapy and Exercise Science, Curtin University, Kent St, Bentley, Western Australia, 6102, Australia. Keith.Hill@Curtin.edu.au.
authors.forename: Keith
authors.initials: K
authors.lastname: Hill
authors.affiliation: Aged Care Services, Austin Health, 300 Waterdale Rd, Heidelberg West, Victoria, 3081, Australia. michael.woodward@austin.org.au.|Department of Medicine, The University of Melbourne, Parkville, Victoria, 3010, Australia. michael.woodward@austin.org.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Woodward
authors.affiliation: Department of Physiotherapy, School of Allied Health, La Trobe University, Kingsbury Drive, Bundoora, Victoria, 3086, Australia. J.Wittwer@latrobe.edu.au.
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Wittwer
authors.affiliation: Statistics and Decision Analysis Academic Platform, The Florey Institute of Neuroscience & Mental Health, 245 Burgundy St, Heidelberg, Victoria, 3084, Australia. leonidc@unimelb.edu.au.
authors.forename: Leonid
authors.initials: L
authors.lastname: Churilov
authors.affiliation: Department of Physiotherapy, School of Allied Health, La Trobe University, Kingsbury Drive, Bundoora, Victoria, 3086, Australia. crventura15@gmail.com.
authors.forename: Cameron
authors.initials: C
authors.lastname: Ventura
authors.affiliation: Stroke Division, The Florey Institute of Neuroscience and Mental Health, 245 Burgundy St, Heidelberg, Victoria, 3084, Australia. J.Bernhardt@unimelb.edu.au.
authors.forename: Julie
authors.initials: J
authors.lastname: Bernhardt
mesh_terms: D002985:Clinical Protocols; D003362:Cost-Benefit Analysis; D003627:Data Interpretation, Statistical; D015444:Exercise; D006801:Humans; D007297:Inpatients; D017063:Outcome Assessment, Health Care; D018401:Sample Size; D016037:Single-Blind Method; D016896:Treatment Outcome