title: Greater intermanual transfer in the elderly suggests age-related bilateral motor cortex activation is compensatory.
abstract: Hemispheric lateralization of movement control diminishes with age; whether this is compensatory or maladaptive is debated. The authors hypothesized that if compensatory, bilateral activation would lead to greater intermanual transfer in older subjects learning tasks that activate the cortex unilaterally in young adults. They studied 10 young and 14 older subjects, learning a unimanual visuomotor task comprising a feedforward phase, where there is unilateral cortical activation in young adults, and a feedback phase, which activates the cortex bilaterally in both age groups. Increased intermanual transfer was demonstrated in older subjects during feedforward learning, with no difference between groups during feedback learning. This finding is consistent with bilateral cortical activation being compensatory to maintain performance despite declining computational efficiency in neural networks.
authors.affiliation: a Institute of Neuroscience , Newcastle University , England.
authors.forename: Sara
authors.initials: S
authors.lastname: Graziadio
authors.forename: Kianoush
authors.initials: K
authors.lastname: Nazarpour
authors.forename: Sabine
authors.initials: S
authors.lastname: Gretenkord
authors.forename: Andrew
authors.initials: A
authors.lastname: Jackson
authors.forename: Janet A
authors.initials: JA
authors.lastname: Eyre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004576:Electromyography; D030141:Feedback, Psychological / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D014163:Transfer, Psychology
keywords: CRUNCH model; HAROLD model; aging; intermanual transfer