title: [Pernicious anemia and autoimmune thyroid diseases in elderly people].
abstract: OBJECTIVE
  Autoimmune thyroid diseases (ATD), and pernicious anemia (PA) in particular, are common in elderly people. The relationship between both of these is currently being discussed. The objective of this study is to determine the correlation between ATD and PA in elderly people, and if there are other associated factors affecting this relationship.
  
  
  METHODS
  The factors studied to analyse this association were social-health variables, autoimmune comorbidity (type 1 diabetes and other autoimmune diseases), the taking of drugs that alter vitamin B12 levels (Metformin and protein bomb inhibitors), and the chronological order in which both diseases appear in this population. A logistic regression analysis was performed to determine which of the described variables could have an on both diseases.
  
  
  RESULTS
  The prevalence was 8.2% for ATD and 3.3% for PA, with a progressive increase in the annual incidence in the past 10 years from 7.1 to 12.7 cases per 1,000 persons>65 years for ATI, and from 1.6 to 7.4 cases for PA. PA was found in 18.6% of the patients with ATD, and the 45% of PA presented with ATD, mainly in women (RR=6.0). The average time in diagnosing the second disease was about 8 years. When there was a third autoimmune disease the likelihood of ATD and PA increased fourfold. Patients with ATD and consuming drugs which were affecting the absorption of vitamin B12 had double the probability of developing a PA compared with those who were not taking medications.
  
  
  CONCLUSIONS
  The results of this study confirm the association between ATI and AP among people 65 or older, also a progressive increase in the incidence of these diseases.
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España. Electronic address: cvelardemayol@yahoo.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Velarde-Mayol
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.
authors.forename: Benito
authors.initials: B
authors.lastname: de la Hoz-García
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: del Cañizo-Fernández-Roldán
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.
authors.forename: Alba Marina
authors.initials: AM
authors.lastname: Hernández-López
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Loza-Candia
authors.affiliation: Equipo de Atención Primaria de Segovia I, Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Segovia, Segovia, España.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cardona-Hernández
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000752:Anemia, Pernicious / Q000150:complications* / Q000453:epidemiology; D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*
keywords: Aged; Aged 80 and over; Anciano; Anciano de más de 80 años; Anemia perniciosa; Atención primaria; Enfermedades tiroideas; Pernicious anemia; Primary health care; Thyroid diseases