title: Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging.
abstract: Herein, we show that a far-red arylidene-squaraine dye is stable against nucleophiles, in contrast to arene-squaraines. Owing to the fluorescence enhancement in apolar media together with high brightness and photostability, this dye was successfully applied to detect the oxytocin G protein-coupled receptor and monitor its internalization in living cells.
authors.affiliation: Laboratoire d'Innovation Thérapeutique, UMR 7200 CNRS/Université de Strasbourg, Faculté de Pharmacie, Labex Medalis, 74 route du Rhin, 67401 Illkirch, France. dominique.bonnet@unistra.fr.
authors.forename: J
authors.initials: J
authors.lastname: Karpenko
authors.forename: A S
authors.initials: AS
authors.lastname: Klymchenko
authors.forename: S
authors.initials: S
authors.lastname: Gioria
authors.forename: R
authors.initials: R
authors.lastname: Kreder
authors.forename: I
authors.initials: I
authors.lastname: Shulov
authors.forename: P
authors.initials: P
authors.lastname: Villa
authors.forename: Y
authors.initials: Y
authors.lastname: Mély
authors.forename: M
authors.initials: M
authors.lastname: Hibert
authors.forename: D
authors.initials: D
authors.lastname: Bonnet
mesh_terms: D000818:Animals; D002417:Cattle; D003116:Color; D003503:Cyclobutanes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D057054:Molecular Imaging; D010636:Phenols / Q000737:chemistry*; D021381:Protein Transport; D018045:Receptors, Oxytocin / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D003503:Cyclobutanes; D005456:Fluorescent Dyes; D010636:Phenols; D018045:Receptors, Oxytocin; C480596:squaraine