title: Effects of macroscopic heterogeneity on propagation in a computationally inexpensive 2D model of the heart.
abstract: We have developed a computationally inexpensive, two-dimensional, bidomain model of the heart to demonstrate the effect of tissue heterogeneity on propagation of cardiac impulses generated by the sino-atrial node (SAN). The geometry consists of a thin sheet of cardiac tissue with designated areas that represent the SAN and atria. The SAN auto-generates continuous impulses that result in waves of normal propagation throughout the tissue. On the introduction of heterogeneous patches with low tissue conductivities, the rhythm of the waveform becomes irregular. The study suggests that simplified and computationally inexpensive models can be insightful tools to better understand the mechanisms that cause atrial fibrillation (AF) and hence more effective treatment methods.
authors.forename: Deepika
authors.initials: D
authors.lastname: Konakanchi
authors.forename: Amy L
authors.initials: AL
authors.lastname: de Jongh Curry
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology; D003198:Computer Simulation; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009200:Myocardial Contraction; D012849:Sinoatrial Node / Q000503:physiopathology