title: Effects of β-endorphin on functional activity of mouse splenocytes under conditions of in vivo blockade of μ,δ-opioid receptors.
abstract: Blockade of δ-receptors with naltrindole under conditions of systemic immunization abolished the stimulatory effect of β-endorphin (0.0005 μg/kg) on the counts of antibody-producing cells and the titer of antierythrocyte antibodies. Injection of β-endorphin to mice led to stimulation of concanavalin A-induced proliferative activity of splenocytes and IL-4 secretion by the naloxone-dependent mechanism. The peptide did not modify the production of IL-2 and IFN-γ.
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia, gein@iegm.ru.
authors.forename: S V
authors.initials: SV
authors.lastname: Gein
authors.forename: T A
authors.initials: TA
authors.lastname: Baeva
authors.forename: V O
authors.initials: VO
authors.lastname: Nebogatikov
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D001615:beta-Endorphin / Q000494:pharmacology*
chemical_list: D007376:Interleukin-2; D017465:Receptors, Opioid, delta; D003208:Concanavalin A; D015847:Interleukin-4; D009270:Naloxone; D009271:Naltrexone; D001615:beta-Endorphin; D007371:Interferon-gamma; C055382:naltrindole