title: Multiscale 3-D + T intracranial aneurysmal flow vortex detection.
abstract: OBJECTIVE
  Characteristics of vortices within intracranial aneurysmal flow patterns have been associated with increased risk of rupture. The classifications of these vortex characteristics are commonly based upon qualitative scores, and are, therefore, subjective to user interpretation. We present a quantitative method for automatic time-resolved characterization of 3-D flow patterns and vortex detection within aneurysms.
  
  
  METHODS
  Our approach is based upon the combination of kernel deconvolution and Jacobian analysis of the velocity field. The deconvolution approach is accurate in detecting vortex centers but cannot discriminate between vortices and high-shear regions. Therefore, this approach is combined with analysis of the Jacobian of the velocity field. Scale-space theory is used to evaluate aneurysmal flow velocity fields at various scales.
  
  
  RESULTS
  The proposed algorithm is applied to computational fluid dynamics and time-resolved 3-D phase-contrast magnetic resonance imaging of aneurysmal flow.
  
  
  CONCLUSIONS
  Results show that the proposed algorithm efficiently detects, visualizes, and quantifies vortices in intracranial aneurysmal velocity patterns at multiple scales and follows the temporal evolution of these patterns.
  
  
  CONCLUSIONS
  Quantitative analysis performed with this method has the potential to reduce interobserver variability in aneurysm classification.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Feliciani
authors.forename: Wouter V
authors.initials: WV
authors.lastname: Potters
authors.forename: Pim
authors.initials: P
authors.lastname: van Ooij
authors.forename: Joppe J
authors.initials: JJ
authors.lastname: Schneiders
authors.forename: Aart J
authors.initials: AJ
authors.lastname: Nederveen
authors.forename: Ed
authors.initials: E
authors.lastname: van Bavel
authors.forename: Charles B
authors.initials: CB
authors.lastname: Majoie
authors.forename: Henk A
authors.initials: HA
authors.lastname: Marquering
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging