title: Methylation of DLEC1 promoter is a predictor for recurrence in Chinese patients with gastric cancer.
abstract: OBJECTIVE
  To investigate promoter methylation in the deleted in lung and esophageal cancer 1 (DLEC1) gene in Chinese patients with gastric cancer.
  
  
  METHODS
  A total of 227 patients with gastric cancer were enrolled. The methylations of the promoter regions of DLEC1 and ACTB were determined using quantitative methylation-specific PCR. The DLEC1 methylation was compared to the clinicopathological variables of gastric cancer.
  
  
  RESULTS
  DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. Patients with DLEC1-hypermethylated gastric cancer had significantly higher recurrence rate than those with DLEC1-hypomethylated gastric cancer (P = 0.025; hazard ratio = 2.43).
  
  
  CONCLUSIONS
  Methylation of DELC1 promoter may be a valuable predictor for recurrence in Chinese patients with gastric cancer.
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China ; Department of Medical Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Ye
authors.affiliation: Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Nanlin
authors.initials: N
authors.lastname: Jiao
authors.affiliation: Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Pu
authors.affiliation: Department of Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.
authors.forename: Guohai
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Sun
mesh_terms: D000368:Aged; D002681:China; D019175:DNA Methylation; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012372:ROC Curve; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C119064:DLEC1 protein, human; D025521:Tumor Suppressor Proteins