title: Synthesis of 4-quinolones via a carbonylative Sonogashira cross-coupling using molybdenum hexacarbonyl as a CO source.
abstract: A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two different protocols is described. The first method (A) yields the cyclized products after only 20 min of microwave (MW) heating at 120 °C. The second method (B) is a gas-free one-pot two-step sequence which runs at room temperature, allowing the use of sensitive substituents (e.g., nitro and bromide groups). For both protocols, molybdenum hexacarbonyl was used as a solid source of CO.
authors.affiliation: Organic Pharmaceutical Chemistry, and §Science for Life Laboratory, Department of Medicinal Chemistry, BMC, Uppsala University , Box-574, SE-751 23 Uppsala, Sweden.
authors.forename: Linda
authors.initials: L
authors.lastname: Åkerbladh
authors.forename: Patrik
authors.initials: P
authors.lastname: Nordeman
authors.forename: Matyas
authors.initials: M
authors.lastname: Wejdemar
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
mesh_terms: D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013696:Temperature
chemical_list: D042462:4-Quinolones; D000480:Alkynes; D007211:Indoles; D009574:Nitro Compounds; D010165:Palladium; D008982:Molybdenum