title: Paget's disease: a clinical review.
abstract: Paget's disease was first described more than 150 years ago, but the exact cause is still unknown--genes and the environment are both important. This article explores the basic science and clinical aspects of this intriguing condition.
authors.affiliation: Senior House Officer in the Department of Care of the Elderly, the Lister Hospital, Stevenage, Hertfordshire SG1 4AB.
authors.forename: Mukul
authors.initials: M
authors.lastname: Shah
authors.forename: Farhan
authors.initials: F
authors.lastname: Shahid
authors.forename: Kuntal
authors.initials: K
authors.lastname: Chakravarty
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000469:Alkaline Phosphatase / Q000097:blood*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D019637:Orthopedic Procedures; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D010014:Osteolysis / Q000000981:diagnostic imaging*; D053244:Osteoprotegerin / Q000235:genetics; D010026:Osteosclerosis / Q000000981:diagnostic imaging*; D011859:Radiography; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics; D000071456:Sequestosome-1 Protein
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D053244:Osteoprotegerin; D053246:Receptor Activator of Nuclear Factor-kappa B; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; D000469:Alkaline Phosphatase