title: Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy.
abstract: In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced gemcitabine delivery, uptake, and metabolism within tumor cells to reduce tumor growth and progression.
authors.affiliation: Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
authors.forename: Esther
authors.initials: E
authors.lastname: Bridges
authors.affiliation: Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address: aharris.lab@oncology.ox.ac.uk.
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D012910:Snake Venoms / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D012910:Snake Venoms; D003841:Deoxycytidine; C422910:Cilengitide; D014700:Verapamil; D000093542:Gemcitabine