title: Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9.
abstract: BACKGROUND
  The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes.
  
  
  METHODS
  Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n = 32), type 1 diabetes mellitus (n = 33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years.
  
  
  RESULTS
  At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed.
  
  
  CONCLUSIONS
  The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus.
authors.forename: Marta
authors.initials: M
authors.lastname: Hernandez
authors.forename: Angels
authors.initials: A
authors.lastname: Mollo
authors.forename: Josep Ramon
authors.initials: JR
authors.lastname: Marsal
authors.forename: Aureli
authors.initials: A
authors.lastname: Esquerda
authors.forename: Ismael
authors.initials: I
authors.lastname: Capel
authors.forename: Manel
authors.initials: M
authors.lastname: Puig-Domingo
authors.forename: Paolo
authors.initials: P
authors.lastname: Pozzilli
authors.forename: Alberto
authors.initials: A
authors.lastname: de Leiva
authors.affiliation: Institut de Recerca Biomedica de Lleida, Universitat de Lleida, Lleida, Spain. didacmauricio@gmail.com.
authors.forename: Didac
authors.initials: D
authors.lastname: Mauricio
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000378:metabolism* / Q000473:pathology; D002096:C-Peptide / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D062407:Meals; D008875:Middle Aged; D019518:Postprandial Period; D013997:Time Factors
chemical_list: D002096:C-Peptide; D007328:Insulin