title: Sugarcane bagasse lignin, and silica gel and magneto-silica as drug vehicles for development of innocuous methotrexate drug against rheumatoid arthritis disease in albino rats.
abstract: The present study clarifies co-therapy action of deliveries from their textural changes point of view. Methotrexate (MTX) was immobilized onto biodegradable lignin, silica gel and iron/silica nanocomposite. Loaded-MTX was i.p. injected into albino rats at doses of 0.25 and 0.5mg/kg/week for 2.5months, after which spleen, liver, testes and knee joint tissues were collected for tests. IFN-γ and IL-17A mRNA gene expressions in spleen in all biological samples were determined by RT-PCR. Physicochemical features of drug carriers were monitored by XRD, BET-PSD, SEM and TEM. Drug inflammatory-site targeting was found to be closely related to the physico-features of deliverers. The interlayered lignin of micro- and meso-pore channels directed MTX toward concealed infected cells in liver and testes tissues, while meso-structured silica flacks satisfied by gathering MTX around knee joints. The magneto-silica nanocomposite targeted MTX toward spleen tissue, which is considered as a lively factory for the production of electron rich compounds.
authors.affiliation: Zoology department, Women College, Ain-Shams University,11566 Cairo, Egypt.
authors.forename: Sanaa M R
authors.initials: SM
authors.lastname: Wahba
authors.affiliation: Chemistry department, Faculty of Science, Ain Shams University, Cairo, Egypt. Electronic address: atef_mouharam@sci.asu.edu.eg.
authors.forename: Atef S
authors.initials: AS
authors.lastname: Darwish
authors.affiliation: Microbiology and Immunology Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
authors.forename: Iman H
authors.initials: IH
authors.lastname: Shehata
authors.affiliation: Zoology department, Women College, Ain-Shams University,11566 Cairo, Egypt.
authors.forename: Sahar S
authors.initials: SS
authors.lastname: Abd Elhalem
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002482:Cellulose / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology; D060526:Magnetic Fields; D008297:Male; D008727:Methotrexate; D051381:Rats; D031786:Saccharum / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D018501:Antirheumatic Agents; D004337:Drug Carriers; D058428:Silica Gel; D002482:Cellulose; C027433:bagasse; D008727:Methotrexate
keywords: Drug targeted deliveries; Iron/silica nanocomposite; Lignin; Methotrexate