title: [The relationship between serum asymmetric dimethylarginine and ABCD2 score in transient ischemic attack patients].
abstract: OBJECTIVE
  To investigate relationships between serum asymmetric dimethylarginine (ADMA) and transient ischemic attack (TIA).
  
  
  METHODS
  Forty healthy controls and 40 patients with TIA were enrolled in the present study. ABCD2 score was used to evaluate risk for future stroke. Serum ADMA levels were measured with ELISA analysis.
  
  
  RESULTS
  Serum level of ADMA was higher in TIA group than that in control group [(0.52 ± 0.06) mmol/L vs (0.23 ± 0.04) mmol/L, P < 0.05]. In TIA subgroup, 19 cases (47.5%) developed cerebral infarction and 23 cases (57.5%) had no stroke history. There is positive correlation between serum ADMA levels and ABCD2 score in both cerebral infarction subjects (r = 0.560, P = 0.013), and no stroke history cases(r = 0.602, P = 0.002). TIA subjects were, then, divided in to two groups based on ABCD2 score as 0-3 group and ≥ 4 group. In general linear model analysis, ADMA level was associated with ABCD2 score (F = 4.39, P = 0.043) after adjusted for age and gender. This situation hold true for subjects within cerebral infarction group (F = 7.327, P = 0.017) or non-previous stroke group(F = 12.300, P = 0.002) . No association could be found between ADMA level and ABCD2 score grouping in subjects with non-infarct (F = 0.523, P = 0.675) or stroke history (F = 0.274, P = 0.609).
  
  
  CONCLUSIONS
  Elevated ADMA is associated with occurrence of TIA. Endothelial dysfunction may play an important role in the pathogenesis of TIA.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yuanjin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China. Email: dsfan@sina.com.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D016022:Case-Control Studies; D002544:Cerebral Infarction; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D012307:Risk Factors; D020521:Stroke
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine