title: Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population-based case-control study.
abstract: OBJECTIVE
  To investigate the association between pulse pressure and risk of hospitalization for cardiovascular events among people with Type 2 diabetes.
  
  
  METHODS
  A population-based case-control study was carried out using data from medical databases. A total of 588 people with Type 2 diabetes from 18 general practices in Cambridgeshire recorded a first hospitalization for a cardiovascular event between 2009 and 2011, and a total of 2920 age-matched, gender-matched and practice-matched control subjects with Type 2 diabetes were selected based on risk-set sampling. Pulse pressure was assessed before admission in 2008-2009. Further dose-response relationships between pulse pressure and risks were explored using spline models.
  
  
  RESULTS
  There was a non-linear relationship between pulse pressure and the risk of hospitalization for a cardiovascular event (P < 0.001 for linearity test). The pulse pressure associated with the lowest risk of hospitalization for a cardiovascular event was 61 (95% CI 57-63) mmHg.
  
  
  CONCLUSIONS
  In people with Type 2 diabetes, pulse pressure is a good predictor of risk of hospitalization for cardiovascular events. The risk is lowest with a pulse pressure of 57-63 mmHg.
authors.affiliation: Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: D
authors.initials: D
authors.lastname: Yu
authors.affiliation: Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
authors.forename: D
authors.initials: D
authors.lastname: Simmons
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology