title: Analysis of spontaneous MEG activity in mild cognitive impairment and Alzheimer's disease using Jensen's divergence.
abstract: The aim of this study was to analyze the changes that mild cognitive impairment (MCI) and Alzheimer's disease (AD) elicit in brain dynamics. For this task, the spontaneous magnetoencephalographic (MEG) activity from 36 AD patients, 18 MCI subjects and 24 healthy controls was analyzed. A disequilibrium measure, Jensen's divergence, was used to estimate the irregularity of neural dynamics. Results revealed that AD patients displayed significant changes (p<;0.05) in the patterns of irregularity in comparison with MCI subjects and healthy controls. Slight differences between MCI subjects and elderly controls were also found. Our results suggest that AD progression is accompanied by region-specific patterns of abnormalities in the neural activity.
authors.forename: Jesús
authors.initials: J
authors.lastname: Poza
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez
authors.forename: María
authors.initials: M
authors.lastname: García
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bachiller
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D015331:Cohort Studies; D003704:Dementia / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009474:Neurons / Q000473:pathology; D009991:Oscillometry; D011336:Probability; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted