title: Novel FGG variant (γ339C→S) confirms importance of the γ326-339 disulphide bond for plasma expression of newly synthesised fibrinogen.
authors.affiliation: Prof. Stephen Brennan, Molecular Pathology Laboratory, Canterbury Health Laboratories, PO Box 151, Christchurch 8011, New Zealand, Tel.: +64 3 364 0549, Fax: +64 3 364 0545, E-mail: steve.brennan@otago.ac.nz.
authors.forename: Stephen O
authors.initials: SO
authors.lastname: Brennan
authors.forename: Andrew
authors.initials: A
authors.lastname: Laurie
authors.forename: Mark
authors.initials: M
authors.lastname: Smith
mesh_terms: D000347:Afibrinogenemia / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004252:DNA Mutational Analysis; D004220:Disulfides / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis* / Q000235:genetics*; D015241:Fibrinogens, Abnormal / Q000096:biosynthesis* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010641:Phenotype; D019106:Postoperative Hemorrhage / Q000097:blood / Q000235:genetics / Q000517:prevention & control; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D004220:Disulfides; D015241:Fibrinogens, Abnormal; C027539:fibrinopeptides gamma; D005340:Fibrinogen; D019158:N-Acetylneuraminic Acid