title: Chemopreventive potential of alpha lipoic acid in the treatment of colon and cervix cancer cell lines.
abstract: OBJECTIVE
  The nuclear factor κB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer. The aim of this study was to examine the influence of the alpha lipoic acid in the chemoprevention of colon and cervix carcinoma in vitro.
  
  
  BACKGROUND
  In recent years, special attention has been paid to the potential chemopreventive properties of antioxidants. There are no published data on the impact of alpha lipoc acid of chemoprevention of cervix and colon cancer.
  
  
  METHODS
  We examined the effect of alpha lipoic acid alone or in combination with cisplatin and 5-fluorouracil on proliferation of the two cell lines, HeLa (human cervical carcinoma cells) and Caco-2 (human colon cancer cells) by MTT test. The measurement of the level of transcription factor NF-κB was also performed in the cells of both cell lines.
  
  
  RESULTS
  At least one of the mechanisms of the antiproliferative and/or cytotoxic effect of alpha lipoic acid on Caco-2 and HeLa cells at high concentrations, the transcription factor NF-κB, may be involved, as well as the products of transcription of genes that are under its control.
  
  
  CONCLUSIONS
  The alpha lipoic acid has proven to be a promising candidate in the combat arena against cancer (Tab. 4, Ref. 31).
authors.forename: I
authors.initials: I
authors.lastname: Damnjanovic
authors.forename: G
authors.initials: G
authors.lastname: Kocic
authors.forename: S
authors.initials: S
authors.lastname: Najman
authors.forename: S
authors.initials: S
authors.lastname: Stojanovic
authors.forename: D
authors.initials: D
authors.lastname: Stojanovic
authors.forename: A
authors.initials: A
authors.lastname: Veljkovic
authors.forename: I
authors.initials: I
authors.lastname: Conic
authors.forename: T
authors.initials: T
authors.lastname: Langerholc
authors.forename: S
authors.initials: S
authors.lastname: Pesic
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D018938:Caco-2 Cells / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018890:Chemoprevention; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects; D008063:Thioctic Acid / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D016328:NF-kappa B; D008063:Thioctic Acid; D002945:Cisplatin; D005472:Fluorouracil