title: Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene.
abstract: This article investigates the application values of Xenogenic (porcine) acellular dermal matrix (XADM) in preparation of a Fournier gangrene wound bed. Thirty-six consecutive cases of patients with Fournier gangrene between 2002 and 2012 were enrolled in our department of our hospital. The patients were divided into two groups according to different methods of wound bed preparation after surgical débridement, including the experimental group (17 cases) and the control group (19 cases). The wounds in the experimental group were covered with XADM after surgical wound débridement, whereas the wounds were cleaned with hydrogen peroxide and sodium hypochlorite solution (one time/day) in the control group. The wound bed preparation time and hospital stay were then compared in the two groups. The wound preparation time was 13.64 ± 1.46 days and hospitalization period was 26.06 ± 0.83 days in the experimental XADM group. In the control group, the wound bed preparation time and hospitalization period were 22.37 ± 1.38 and 38.11 ± 5.60 days, respectively. The results showed statistical differences between these two groups. When used in wound débridement after Fournier gangrene, XADM protects interecological organizations, promotes the growth of granulation tissues, and maximally retains function and morphology of the perineum and penis.
authors.affiliation: Burn Wound Surgery Department of People's Hospital, Xinjiang Uygur Autonomous Region, P.R. China.
authors.forename: Zhaoxin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Lv
authors.forename: Masut
authors.initials: M
authors.lastname: Mamat
authors.forename: Zhao
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Zhou
authors.forename: Lihua
authors.initials: L
authors.lastname: Liu
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D062088:Acellular Dermis; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D003646:Debridement; D018934:Fournier Gangrene / Q000382:microbiology / Q000601:surgery*; D006097:Granulation Tissue / Q000502:physiology*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D013552:Swine; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*