title: Does casein phosphopeptid amorphous calcium phosphate provide remineralization on white spot lesions and inhibition of Streptococcus mutans?
abstract: OBJECTIVE
  The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization.
  
  
  METHODS
  The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis.
  
  
  RESULTS
  DIAGNOdent measurements were increased by time (p = 0.002) in control group and no statistically significant diference (p = 0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period.
  
  
  CONCLUSIONS
  These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.
authors.affiliation: Department of Pedodontics, Aykut-Yetkiner University of Ege, Izmir, Turkey.  a_aykut@hotmail.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Aykut-Yetkiner
authors.forename: Nazan
authors.initials: N
authors.lastname: Kara
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ateş
authors.forename: Nazan
authors.initials: N
authors.lastname: Ersin
authors.forename: Fahinur
authors.initials: F
authors.lastname: Ertuğrul
mesh_terms: D000293:Adolescent; D058491:Bacterial Load / Q000187:drug effects; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use*; D003731:Dental Caries / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007834:Lasers; D008297:Male; D012463:Saliva / Q000378:metabolism / Q000382:microbiology; D012636:Secretory Rate / Q000502:physiology; D013295:Streptococcus mutans / Q000187:drug effects*; D014089:Tooth Remineralization / Q000379:methods*; D014100:Toothpastes / Q000627:therapeutic use
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D014100:Toothpastes; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides