title: Hypomelanosis of Ito: a round on the frequency and type of epileptic complications.
abstract: There is an ample evidence that hypopigmentation of the skin along the Blaschko's lines is frequently associated with neurological disorders. Nowadays, the term "Hypomelanosis of Ito" (HI) is applied when, together with the cutaneous lesions, various and multisystem organs are involved. Among these, the most frequent are cerebral manifestations, such as cognitive delay and epileptic seizures. For this reason, hypomelanosis of Ito has been included in the group of neurocutaneous syndromes, neurologic manifestations being one of the most frequent. Epileptic seizures have been reported in patients with this disorder, but in a very few particular attention has been focused on the type and frequency of epilepsy and on the response to the treatment. Herein, we report on five patients with HI who showed episodes of epileptic seizures with onset in childhood, in absence of malformative anomalies except for the skin lesions. A survey on the frequency and types of epileptic seizures in HI children and in the literature is reported.
authors.affiliation: Unit of Pediatrics and Pediatric Emergency "Costanza Gravina", University-Hospital "Vittorio Emanuele, Policlinic", University of Catania, Via Santa Sofia 78, Catania, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Pavone
authors.forename: Andrea Domenico
authors.initials: AD
authors.lastname: Praticò
authors.forename: Martino
authors.initials: M
authors.lastname: Ruggieri
authors.forename: Raffaele
authors.initials: R
authors.lastname: Falsaperla
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male