title: Functional validation of an implantable medical dosing device by MRI at 3T.
abstract: Sustained release of a small molecule from a prototype implantable drug delivery device was monitored via MRI in an ex vivo tissue phantom over a period of two days. T1 mapping was used as a method to quantify analyte concentration. Continuous, controlled release was observed. The MRI methodology was thus found to be appropriate for device validation and quality assurance/control.
authors.forename: Jeff R
authors.initials: JR
authors.lastname: Anderson
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferrati
authors.forename: Chistof
authors.initials: C
authors.lastname: Karmonik
authors.forename: Alessandro
authors.initials: A
authors.lastname: Grattoni
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D006801:Humans; D015918:Infusion Pumps, Implantable; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media