title: Determining oxidant and antioxidant status in patients with genital warts.
abstract: OBJECTIVE
  Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of patients. Genital warts usually appear in the perianal and perigenital regions. Asymptomatic warts may be activated after years and may damage natural immunity. The inflammation that occurs during this process may lead to an imbalance between the prooxidant and the antioxidant systems. The aim of this study was to investigate erythrocyte glutathione peroxidase (GSH-Px) activity, serum paraoxonase enzyme levels, and oxidative stress levels in patients with genital warts.
  
  
  METHODS
  In total, 32 patients with genital warts and 35 healthy subjects were included in this study. Erythrocyte GSH-Px activity, serum catalase activity, and paraoxonase enzyme, and malondialdehyde (MDA) levels were determined.
  
  
  RESULTS
  Erythrocyte GSH-Px activity, serum MDA levels, and catalase activity were significantly higher in patients with genital warts than in controls (P < 0.01, P < 0.05, and P < 0.05, respectively). However, serum paraoxonase enzyme levels were not significantly different between groups (P > 0.05). Serum triglyceride levels were significantly lower in patients with genital warts than in controls (P < 0.01). However, there were no statistically significant differences between groups with respect to total cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol levels (all P > 0.05).
  
  
  CONCLUSIONS
  Our data suggest that oxidative stress is increased in genital warts. Increased oxidative stress levels may contribute to the pathogenesis of genital warts, and prolonged HPV infection due to chronic inflammation could also affect oxidative stress.
authors.forename: Erdem
authors.initials: E
authors.lastname: Cokluk
authors.forename: Mehmet Ramazan
authors.initials: MR
authors.lastname: Sekeroglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Ragip
authors.initials: R
authors.lastname: Balahoroglu
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Zubeyir
authors.initials: Z
authors.lastname: Huyut
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D003218:Condylomata Acuminata / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016877:Oxidants / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D016877:Oxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase
keywords: Catalase activity; Genital warts; Glutathione peroxidase activity; Lipid parameters; Malondialdehyde; Paraoxonase-1