title: Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.
abstract: Cellular contractility regulates tissue cohesion and morphogenesis. In epithelia, E-cadherin adhesion couples the contractile cortices of neighboring cells together to produce tension at junctions that can be transmitted across the epithelium in a planar fashion. We have recently demonstrated that contractility is also patterned in the apical-lateral axis within epithelial junctions. Our findings highlight the role that cytoskeletal regulation plays in controlling the levels of intra-junctional tension. Of note, dysregulation of this apicolateral pattern of tension can drive oncogenic cell extrusion. In this article, we provide a detailed description of the actomyosin cytoskeleton organization during oncogenic extrusion and discuss the implications of cell extrusion in cancer.
authors.affiliation: a Divisions of Cell Biology and Molecular Medicine ; The University of Queensland ; St. Lucia , Brisbane , Australia.
authors.forename: Selwin K
authors.initials: SK
authors.lastname: Wu
authors.forename: Anne K
authors.initials: AK
authors.lastname: Lagendijk
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Hogan
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Gomez
authors.forename: Alpha S
authors.initials: AS
authors.lastname: Yap
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D018938:Caco-2 Cells; D015820:Cadherins / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*; D008954:Models, Biological; D024462:Myosin Type II / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016283:Proto-Oncogene Proteins p21(ras); D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000378:metabolism
chemical_list: D000199:Actins; D015820:Cadherins; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D024462:Myosin Type II; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
keywords: E-Cadherin; actin; cell extrusion; myosin; oncogene