title: Effect of low-dose, long-term roxithromycin on airway inflammation and remodeling of stable noncystic fibrosis bronchiectasis.
abstract: BACKGROUND
  Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases.
  
  
  OBJECTIVE
  To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients with NCFB under steady state.
  
  
  METHODS
  The study involved an open-label design in 52 eligible Chinese patients with NCFB, who were assigned to control (receiving no treatment) and roxithromycin (receiving 150 mg/day for 6 months) groups. At baseline and 6 months, the inflammatory markers such as interleukin- (IL-)8, neutrophil elastase (NE), matrix metalloproteinase- (MMP)9, hyaluronidase (HA), and type IV collagen in sputum were measured, along with the detection of dilated bronchus by throat computed tomography scan, and assessed the exacerbation.
  
  
  RESULTS
  Forty-three patients completed the study. The neutrophil in the sputum was decreased in roxithromycin group compared with control (P < 0.05). IL-8, NE, MMP-9, HA, and type IV collagen in sputum were also decreased in roxithromycin group compared with the control group (all P < 0.01). Airway thickness of dilated bronchus and exacerbation were reduced in roxithromycin group compared with the control (all P < 0.05).
  
  
  CONCLUSIONS
  Roxithromycin can reduce airway inflammation and airway thickness of dilated bronchus in patients with NCFB.
authors.affiliation: Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.
authors.forename: Jifeng
authors.identifier: 0000-0002-6738-0015
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China.
authors.forename: Lianghong
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China.
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Radiology, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China.
authors.forename: Dengjun
authors.initials: D
authors.lastname: Zhong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001980:Bronchi / Q000378:metabolism; D024141:Collagen Type IV / Q000378:metabolism; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism; D019272:Leukocyte Elastase / Q000378:metabolism; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D011788:Quality of Life; D015575:Roxithromycin / Q000494:pharmacology*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; C508606:CXCL8 protein, human; D024141:Collagen Type IV; D016209:Interleukin-8; D015575:Roxithromycin; D006821:Hyaluronoglucosaminidase; D019272:Leukocyte Elastase; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9