title: Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products.
abstract: In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester couplings and on this mechanistic background we then present and discuss a collection of successful examples from the literature.
authors.affiliation: Chemical Biology Laboratory, Department of Chemistry, Aarhus University, DK-8000, Aarhus C, Denmark. thpou@chem.au.dk.
authors.forename: Michail
authors.initials: M
authors.lastname: Tsakos
authors.forename: Eva S
authors.initials: ES
authors.lastname: Schaffert
authors.forename: Lise L
authors.initials: LL
authors.lastname: Clement
authors.forename: Nikolaj L
authors.initials: NL
authors.lastname: Villadsen
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Poulsen
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004952:Esters; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D004952:Esters