title: Early detection of regional and global left ventricular myocardial function using strain and strain-rate imaging in patients with metabolic syndrome.
abstract: BACKGROUND
  Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function.
  
  
  METHODS
  Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S), peak systolic strain-rate (SR-s), peak diastolic strain-rate (SR-e).
  
  
  RESULTS
  There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.
  
  
  CONCLUSIONS
  In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Sun
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Yang
authors.forename: Rong-Juan
authors.initials: RJ
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Jiao
authors.initials: J
authors.lastname: Yang
authors.forename: Zhi-An
authors.initials: ZA
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
mesh_terms: D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology*