title: Carbohydrate Intake, Glycemic Index, Glycemic Load, and Stroke: A Meta-analysis of Prospective Cohort Studies.
abstract: The objective of this study was to investigate associations between carbohydrate intake/glycemic index (GI)/glycemic load (GL) and stroke risk. A literature search of MEDLINE, Embase, Web of Science, and CBM databases was performed to retrieve eligible studies published up to March 2014. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to evaluate the strength of this association. Publication bias was assessed by the Egger's regression asymmetry test and Begg's rank correlation test with Begg's funnel plot. All analyses were conducted using software STATA 12.0 (StataCorp LP, College Station, TX) and SAS version 9.1 (SAS Institute Inc, Cary, NC). We identified 7 prospective studies that met the inclusion criteria and processed data from cohort studies to update available evidence. There were 25 independent estimates and 225 000 participants free of diabetes from 6 different countries; 3046 stroke events were included; and the follow-up range was 5 to 18 years. High GI was not associated with risk of stroke events (pooled RR = 1.10; 95% CI: 0.99-1.21); GL was a risk factor for stroke (pooled RR = 1.19; 95% CI: 1.05-1.36). There was no significant association between high carbohydrate intake and stroke risk (RR = 1.12; 95% CI: 0.93-1.35). A daily high GL diet is the risk factor of stroke event, and further researches need to verify the meta-analyses results and study associated mechanisms.
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Xianlei
authors.initials: X
authors.lastname: Cai
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Gaoyang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jin
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Yu
authors.affiliation: Zhejiang University, Hangzhou, P R China lixiuyang@zju.edu.cn zjicu@vip.163.com fwang@zju.edu.cn.
authors.forename: Xiuyang
authors.initials: X
authors.lastname: Li
authors.affiliation: Zhejiang Hospital, Hangzhou, P R China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Zhejiang University, Hangzhou, P R China.
authors.forename: Fudi
authors.initials: F
authors.lastname: Wang
authors.affiliation: Zhejiang Hospital, Hangzhou, P R China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.affiliation: Zhejiang Hospital, Hangzhou, P R China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ding
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000009:adverse effects*; D038321:Glycemic Index; D006801:Humans; D011446:Prospective Studies; D012306:Risk; D020521:Stroke / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates
keywords: carbohydrate intake; dose-response; glycemic index; glycemic load; meta-analysis; stroke