title: Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex.
abstract: Neurons in the dorsolateral prefrontal cortex (DLPFC) encode a diverse array of sensory and mnemonic signals, but little is known about how this information is dynamically routed during decision making. We analyzed the neuronal activity in the DLPFC of monkeys performing a probabilistic reversal task where information about the probability and magnitude of reward was provided by the target color and numerical cues, respectively. The location of the target of a given color was randomized across trials and therefore was not relevant for subsequent choices. DLPFC neurons encoded signals related to both task-relevant and irrelevant features, but only task-relevant mnemonic signals were encoded congruently with choice signals. Furthermore, only the task-relevant signals related to previous events were more robustly encoded following rewarded outcomes. Thus, multiple types of neural signals are flexibly routed in the DLPFC so as to favor actions that maximize reward.
authors.affiliation: Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Christopher H
authors.identifier: 0000000315741162
authors.initials: CH
authors.lastname: Donahue
authors.affiliation: 1] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Psychology, Yale University, New Haven, Connecticut, USA.
authors.forename: Daeyeol
authors.identifier: 000000033474019X
authors.initials: D
authors.lastname: Lee
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D011337:Probability Learning; D011597:Psychomotor Performance / Q000502:physiology; D012201:Reward; D014796:Visual Perception / Q000502:physiology