title: Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules.
abstract: Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.
authors.affiliation: Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.
authors.forename: Luciana
authors.initials: L
authors.lastname: Méndez
authors.forename: Ernesto G
authors.initials: EG
authors.lastname: Mata
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008872:Microwaves; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000473:Alkanes; D000475:Alkenes; D012428:Ruthenium
keywords: chalcones; microwave heating; olefin metathesis; solid-phase organic synthesis; β-phenylpropiophenone derivatives