title: Micromachined "Side-Viewing" Optical Sensor Probe for Detection of Esophageal Cancers.
abstract: In this paper, we report the design, fabrication and testing of a new miniaturized optical sensor probe with "side viewing" capability for oblique incidence diffuse reflectance spectrometry. The sensor probe consists of a lithographically patterned polymer waveguides chip and two micromachined positioning substrates and source/collection fibers to achieve 45° light incidence and collection of spatially resolved diffuse reflectance. Diffuse reflectance of human esophageal surface has been successfully measured for differentiation of cancerous tissues from normal ones.
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: A
authors.initials: A
authors.lastname: Garcia-Uribe
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Balareddy
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: J
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Wojcik
authors.affiliation: Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, MO 63130, USA.
authors.forename: L V
authors.initials: LV
authors.lastname: Wang
keywords: Micromachined probe; diffuse reflectance; esophageal cancer; oblique incidence