title: Renaissance of MMPs as therapeutic targets? Maybe.
abstract: Matrix metalloproteases (MMPs) have been implicated in a number of different human diseases and are currently one of the actively pursued targets in drug discovery and development. In this issue of Structure, Udi and colleagues describe how an inhibitory antibody, LEM-2/15, affects a member of the MMP family, MT1-MMP.
authors.affiliation: Division of Dermatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63141, USA. Electronic address: goldberg@wustl.edu.
authors.forename: Gregory I
authors.initials: GI
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000737:chemistry* / Q000378:metabolism*; D061965:Matrix Metalloproteinase Inhibitors / Q000378:metabolism*
chemical_list: D000906:Antibodies; D061965:Matrix Metalloproteinase Inhibitors; D053511:Matrix Metalloproteinase 14