title: Oligodendroglial Development: New Roles for Chromatin Accessibility.
abstract: In the central nervous system, the generation of mature oligodendrocytes from their progenitors is a critical step in myelination, which is essential for normal nervous system function. Thus, understanding the regulatory mechanism underlying oligodendroglial development is of great importance, especially for the development of new therapeutic strategies that promote remyelination in demyelinating diseases, such as multiple sclerosis. Previous studies have focused on genetic patterns and revealed a network of cell signaling pathways and related transcription factors involved in oligodendroglial lineage development. Recently, epigenetic regulation, which refers to regulation of gene expression by adjusting the environment of the genes has been shown to play a profound role during oligodendroglial development. In this review, we summarize the recent data demonstrating the effects of chromatin modification and remodeling in regulating oligodendroglial development and discuss the use of high-throughput analysis and bio-informatics in future studies.
authors.affiliation: Department of Histology and Embryology, Faculty of Basic Medicine, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, China.
authors.forename: Nanxin
authors.initials: N
authors.lastname: Huang
authors.affiliation: Department of Histology and Embryology, Faculty of Basic Medicine, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, China.
authors.forename: Jianqin
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Histology and Embryology, Faculty of Basic Medicine, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, China xiaolan35@hotmail.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology*
chemical_list: D002843:Chromatin
keywords: chromatin remodeling; development; differentiation; histone modification; oligodendroglia