title: The efficacy of negative pressure wound therapy on chemotherapeutic extravasation ulcers: An experimental study.
abstract: BACKGROUND
  The extravasation of the chemotherapeutic agents is not an unusual phenomenon. Necrosis of the skin and underlying structures has been reported, depending on the cytotoxicity of the extravasating drug. Despite the presence of some antidotes, such wounds tend to enlarge with time and are likely to resist the treatment.
  
  
  OBJECTIVE
  The objective of this study was to investigate the efficacy of negative pressure wound therapy (NPWT) on extravasation ulcers.
  
  
  METHODS
  Animals were separated into two groups; conventional dressing group and NPWT group.
  
  
  METHODS
  Extravasation necrosis was established by intradermal doxorubicin injection. Following the debridement of the necrotic areas, one group of animals was treated with the conventional dressing while NPWT was applied to the other group. The wound areas were measured, and then biopsies were taken on the 3(rd), 7(th) and 14(th) days after the debridement.
  
  
  METHODS
  SPSS 11.5 for Windows was used. Two-way ANOVA test was used to compare wound areas between groups. Willcoxon sign test with Bonferroni correction was used to compare histological scores between groups. Chi-square test with Bonferroni correction was used to compare histological scores within the group between the days.
  
  
  RESULTS
  There is no significant difference in terms of inflammatory cell count, neovascularisation, granulation tissue formation between the groups. Contrary to these results wound areas at the end of the treatment were smaller in the NPWT group compared with the dressing group.
  
  
  CONCLUSIONS
  There is the superiority of NPWT over conventional dressing in chemotherapeutic extravasation wounds as well as the wound area is concerned, but it is not proven histologically.
authors.affiliation: Departments of Plastic and Reconstructive Surgery, Private Aile Hospital, Istanbul, Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Iscı
authors.affiliation: Faculty of Medicine, Acibadem University, Istanbul, Turkey.
authors.forename: Halil I
authors.initials: HI
authors.lastname: Canter
authors.affiliation: Faculty of Medicine, Necmettin Erbakan University Meram, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Dadacı
authors.affiliation: Department of Histology and Embryology, Hacettepe University, Ankara, Turkey.
authors.forename: Pergin
authors.initials: P
authors.lastname: Atılla
authors.affiliation: Department of Histology and Embryology, Hacettepe University, Ankara, Turkey.
authors.forename: Ayse N
authors.initials: AN
authors.lastname: Cakar
authors.affiliation: Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kecık
keywords: Chemotherapeutic extravasation; extravasation ulcer; negative pressure wound therapy; rabbit