title: The roles of CD147 and/or cyclophilin A in kidney diseases.
abstract: CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
authors.affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China ; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China.
authors.forename: Xin
authors.identifier: 0000-0003-2649-761X
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China.
authors.forename: Chunting
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Qie
authors.affiliation: Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China.
authors.forename: Jianxin
authors.identifier: 0000-0002-0658-8648
authors.initials: J
authors.lastname: Zhou
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology; D000818:Animals; D051926:Basigin / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism; D051242:Caveolin 1 / Q000378:metabolism; D021984:Cyclophilin A / Q000378:metabolism*; D005355:Fibrosis / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D016023:Integrins / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism; D051379:Mice; D009393:Nephritis / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C497886:BSG protein, human; D051242:Caveolin 1; D016023:Integrins; D034741:RNA, Small Interfering; D051926:Basigin; D021984:Cyclophilin A