title: First case of disseminated infection with Nocardia cerradoensis in a human.
abstract: Here we report in a human, a renal transplant patient, the first disseminated infection with Nocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA, gyrB, and hsp65 gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.
authors.affiliation: Medical School, University Rennes 1, Rennes, France IGDR-UMR 6290-CNRS, University Rennes 1, Rennes, France Department of Microbiology, CHU Rennes-Hôpital Pontchaillou, Rennes, France samer.kayal@chu-rennes.fr caroline.piau@chu-rennes.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Piau
authors.affiliation: Medical School, University Rennes 1, Rennes, France Department of Pulmonology, CHU Rennes-Hôpital Pontchaillou, Rennes, France.
authors.forename: Mallorie
authors.initials: M
authors.lastname: Kerjouan
authors.affiliation: Medical School, University Rennes 1, Rennes, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Le Mouel
authors.affiliation: Medical School, University Rennes 1, Rennes, France Department of Infectious Diseases, CHU Rennes-Hôpital Pontchaillou, Rennes, France.
authors.forename: Solene
authors.initials: S
authors.lastname: Patrat-Delon
authors.affiliation: Medical School, University Rennes 1, Rennes, France Department of Neurosurgery, CHU Rennes-Hôpital Pontchaillou, Rennes, France.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Henaux
authors.affiliation: Medical School, University Rennes 1, Rennes, France Department of Radiology, CHU Rennes-Hôpital Pontchaillou, Rennes, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Brun
authors.affiliation: Medical School, University Rennes 1, Rennes, France Department of Nephrology, CHU Rennes-Hôpital Pontchaillou, Rennes, France.
authors.forename: Marie-Pascale
authors.initials: MP
authors.lastname: Morin
authors.affiliation: Medical School, University Rennes 1, Rennes, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gautier
authors.affiliation: French Observatory of Nocardia, UMR 5557-CNRS, University Lyon 1, Lyon, France.
authors.forename: Veronica
authors.initials: V
authors.lastname: Rodriguez-Nava
authors.affiliation: Medical School, University Rennes 1, Rennes, France IGDR-UMR 6290-CNRS, University Rennes 1, Rennes, France Department of Microbiology, CHU Rennes-Hôpital Pontchaillou, Rennes, France samer.kayal@chu-rennes.fr caroline.piau@chu-rennes.fr.
authors.forename: Samer
authors.identifier: http://orcid.org/0000-0002-4734-1713
authors.initials: S
authors.lastname: Kayal
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001921:Brain / Q000382:microbiology / Q000473:pathology; D015780:Carbapenems / Q000627:therapeutic use; D016000:Cluster Analysis; D027081:DNA Gyrase; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D005260:Female; D006360:Heat-Shock Proteins; D006801:Humans; D016030:Kidney Transplantation; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008875:Middle Aged; D008969:Molecular Sequence Data; D009615:Nocardia / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D011860:Radiography, Abdominal; D013902:Radiography, Thoracic; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology; D017422:Sequence Analysis, DNA; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D066027:Transplant Recipients; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D006360:Heat-Shock Proteins; D012336:RNA, Ribosomal, 16S; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D027081:DNA Gyrase