title: Chemical constituents from the aerial parts of Melandrium firmum.
abstract: Two new anthraquinones, melrubiellin C (1) and melrubiellin D (2), were isolated from the aerial parts of Melandrium firmum Rohrbach, together with eight known compounds (3-10). The structures of these compounds were elucidated using 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. All isolated compounds were tested for their cytotoxicity against NCI-H460, Hep G2, MKN-28 and A-549 cells. Of these 10 compounds, 1 and 2 exhibited moderate cytotoxicity with IC50 values ranging from 9.54 to 32.41 μM.
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Li
authors.affiliation: Yanbian University Hospital, Yanji, 133000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Yanbian University Hospital, Yanji, 133000, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Da-Lei
authors.initials: DL
authors.lastname: Yao
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Zheng
authors.affiliation: Cancer Research Center, Yanbian University Medical College, Yanji, 133002, China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Lin
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Jiong-Mo
authors.initials: JM
authors.lastname: Cui
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China. gli@ybu.edu.cn.
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Anthraquinone dimmer; Caryophyllaceae; Cytotoxicity; Melandrium firmum