title: Thermogenesis in white adipose tissue: An unfinished story about PPARγ.
abstract: BACKGROUND
  Recruiting thermogenic adipocytes in white adipose tissue represents a potential therapeutic strategy for obesity. Interestingly, PPARγ, a major regulator of lipogenesis, is also a key factor in inducing thermogenic genes in adipose tissue.
  
  
  OBJECTIVE
  We summarize some of the recent findings regarding the biology of beige adipocytes and their potential significance for metabolic health. We also discuss the role of PPARγ in development of beige adipocyte phenotype and in inducing two apparently divergent processes, namely, lipogenesis and thermogenesis.
  
  
  CONCLUSIONS
  PPARγ post-translation modifications and differential coregulator recruitment may be key factors in defining adipocyte commitment with lipogenesis or thermogenesis.
  
  
  CONCLUSIONS
  Dissecting the mechanisms underlying its thermogenic effects may prompt the development of a new generation of PPARγ-based therapies.
authors.affiliation: Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, Brasilia, CEP 70919-970, Brazil.
authors.forename: Guilherme Martins
authors.initials: GM
authors.lastname: Santos
authors.affiliation: Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, Brasilia, CEP 70919-970, Brazil.
authors.forename: Francisco de Assis Rocha
authors.initials: Fde A
authors.lastname: Neves
authors.affiliation: Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, Brasilia, CEP 70919-970, Brazil. Electronic address: angelicamato@unb.br.
authors.forename: Angélica Amorim
authors.initials: AA
authors.lastname: Amato
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D006801:Humans; D050155:Lipogenesis / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology*; D022722:Thermogenesis / Q000502:physiology*
chemical_list: D047495:PPAR gamma
keywords: Beige adipocytes; PPARγ; PPARγ agonists; Thermogenesis