title: [Study on preparation of breviscapine liposomes and chemicophysical properties].
abstract: OBJECTIVE
  To prepare breviscapine pro-liposomes and evaluate its properties and stability, as well as its interaction with the mimic-membrane.
  
  
  METHODS
  Breviscapine liposomes were prepared by thin film-lyophilization method. Phase inversion temperature was measured by electrical conductance method and coalescence kinetics was studied. Water/n-octanol trans-membrane diffusion model was designed to study the dynamic distribution behavior between two phases, through the determination of diffusion rate of breviscapine and liposomes.
  
  
  RESULTS
  The phase inversion temperature was 63 degrees C, the activity energy for coalescence was 14.66 kJ/mol. The results suggested that breviscapine from liposomes staying on the interface were found more than the breviscapine infusion.
  
  
  CONCLUSIONS
  Breviscapine liposomes prepared with thin film-lyophilization method have good physicochemical properties and stability, which is beneficial to treatment.
authors.affiliation: Hainan Institute for Drug Control, Haikou, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Yan
authors.forename: Fei
authors.initials: F
authors.lastname: Xiong
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhao
authors.forename: Jia-Bi
authors.initials: JB
authors.lastname: Zhu
mesh_terms: D055598:Chemical Phenomena; D005419:Flavonoids / Q000737:chemistry*; D008081:Liposomes; D013696:Temperature
chemical_list: D005419:Flavonoids; D008081:Liposomes; C061097:breviscapine