title: Irisin: a new molecular marker and target in metabolic disorder.
abstract: Irisin is a newly discovered exercise-mediated myokine which regulates energy metabolism and has been the subject of much recent research. Irisin plays an important role in metabolic diseases making it a potential new target to combat obesity and its associated disorders, such as T2DM. However, the results of several recent studies investigating the effects of irisin have been controversial. The present review will introduce the discovery of irisin, the role of irisin in metabolic disorders, possible mechanisms, and unanswered questions for future research.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Jacky_orange@163.com.|Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Jacky_orange@163.com.
authors.forename: Jia-qi
authors.initials: JQ
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. huangyueye19890603@163.com.
authors.forename: Yue-ye
authors.initials: YY
authors.lastname: Huang
authors.affiliation: Department of Neurology, Weill Cornell Medical College, New York, NY, 10065, USA. agusdon@gmail.com.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Gusdon
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. qushencn@hotmail.com.|Nanjing Medical University, Nanjing, Jiangsu, 210029, China. qushencn@hotmail.com.
authors.forename: Shen
authors.initials: S
authors.lastname: Qu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005353:Fibronectins