title: Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays.
abstract: Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093-0358, USA. kgodula@ucsd.edu.
authors.forename: Mia L
authors.initials: ML
authors.lastname: Huang
authors.forename: Miriam
authors.initials: M
authors.lastname: Cohen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Fisher
authors.forename: Robert T
authors.initials: RT
authors.lastname: Schooley
authors.forename: Pascal
authors.initials: P
authors.lastname: Gagneux
authors.forename: Kamil
authors.initials: K
authors.lastname: Godula
mesh_terms: D046228:Microarray Analysis / Q000379:methods*; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000737:chemistry* / Q000378:metabolism*; D011134:Polysaccharides / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011134:Polysaccharides