title: Cobalt(III)porphyrin to target G-quadruplex DNA.
abstract: G-quadruplex DNA ligands attract much attention because of their potential use in biology. Indeed they may interfere with G-quadrulex nucleic acid function in cells. Most of the G-quadruplex ligands so far reported (including also metal complexes) are large planar aromatic compounds that interact by π-π stacking with an external G-quartet of quadruplex. Porphyrins are well-known G-quadruplex ligands. We report herein a new porphyrin scaffold (meso-tetrakis(4-(N-methyl-pyridinium-2-yl)phenyl)porphyrin) able to strongly and selectively bind to G-quadruplex DNA. We show that even when this porphyrin is metallated with cobalt(III), i.e. it carries two water molecules as axial ligands on the cobalt ion, on each face of the porphyrin, the interaction occurs by a π-stacking-like mode with an external G-quartet of quadruplex DNA.
authors.affiliation: CNRS, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, BP 44099, F-31077 Toulouse, France. genevieve.pratviel@lcc-toulouse.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Sabater
authors.forename: Pei-Ju
authors.initials: PJ
authors.lastname: Fang
authors.forename: Chi-Fon
authors.initials: CF
authors.lastname: Chang
authors.forename: Aurore
authors.initials: A
authors.lastname: De Rache
authors.forename: Enora
authors.initials: E
authors.lastname: Prado
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dejeu
authors.forename: Antonio
authors.initials: A
authors.lastname: Garofalo
authors.forename: Jung-Hsin
authors.initials: JH
authors.lastname: Lin
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
authors.forename: Eric
authors.initials: E
authors.lastname: Defrancq
authors.forename: Geneviève
authors.initials: G
authors.lastname: Pratviel
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D007700:Kinetics; D019906:Nuclear Magnetic Resonance, Biomolecular; D009691:Nucleic Acid Denaturation; D011166:Porphyrins / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D056831:Coordination Complexes; D011166:Porphyrins; D003035:Cobalt