title: Discovery of novel antibiotic resistance genes through metagenomics.
abstract: Antibiotic resistance (AR) represents a challenge for the treatment of infectious diseases. Traditionally, antibiotic resistance determinants have been retrieved from culturable bacteria which represent a minor fraction of the total microbial diversity found in natural environments such as soils. In this review, we summarize recent advances in the study of antibiotic resistance using two main culture-independent approaches: sequence-based metagenomics and functional metagenomics.
authors.forename: Marcos
authors.initials: M
authors.lastname: López-Pérez
authors.affiliation: Department of Environmental Sciences, Metropolitan Autonomous University (Lerma Unit), Lerma de Villada, Mexico. m.lopez@correo.ler.uam.mx.
authors.forename: Salvador
authors.initials: S
authors.lastname: Mirete
mesh_terms: D001419:Bacteria / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D056186:Metagenomics