title: [Effect of the microencapsulation process parameters piroxicam by complex coacervation].
abstract: BACKGROUND
  The gelatin-acacia system is used for the microencapsulation of piroxicam by complex coacervation.
  
  
  METHODS
  The effect of some formulation parameters and process, namely the ratio of gelatin/gum acacia, core/wall ratio, concentration of crosslinking agent and crosslinking time are studied. The microcapsules properties are evaluated.
  
  
  RESULTS
  The results showed that the microcapsules have a spherical shape, a coacervation efficiency greater than 70%, an average diameter less than 250 microns, a good stability and finally, the better values are obtained for gelatin/acacia ratio (5/3), ratio core/wall (1/4), an amount of 2 mL of crosslinking agent and a crosslinking time of 60 minutes.
authors.affiliation: Laboratoire des phénomènes de transfert, faculté de génie mécanique et de génie des procédés, université des sciences et de la technologie Houari Boumediene, BP 32 El Alia, Bab Ezzouar, Alger, Algérie. Electronic address: llamoudi@usthb.dz.
authors.forename: L
authors.initials: L
authors.lastname: Lamoudi
authors.affiliation: Labratoire de pharmacie galénique, faculté des sciences pharmaceutiques et biologiques, université Paris Descartes, 95270 Paris cedex 06, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Chaumeil
authors.affiliation: Laboratoire des phénomènes de transfert, faculté de génie mécanique et de génie des procédés, université des sciences et de la technologie Houari Boumediene, BP 32 El Alia, Bab Ezzouar, Alger, Algérie.
authors.forename: K
authors.initials: K
authors.lastname: Daoud
mesh_terms: D000045:Acacia; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002214:Capsules; D003432:Cross-Linking Reagents; D004339:Drug Compounding; D005079:Excipients; D005780:Gelatin; D010316:Particle Size; D010894:Piroxicam / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D003432:Cross-Linking Reagents; D005079:Excipients; D010894:Piroxicam; D005780:Gelatin
keywords: Agent de réticulation; Coacervation complexe; Complex coacervation; Core/wall; Crosslinking agent; Crosslinking time; Gelatin/acacia; Gélatine/acacia; Noyau/paroi; Piroxicam; Temps de réticulation