title: Functionalized solid electrodes for electrochemical biosensing of purine nucleobases and their analogues: a review.
abstract: Interest in electrochemical analysis of purine nucleobases and few other important purine derivatives has been growing rapidly. Over the period of the past decade, the design of electrochemical biosensors has been focused on achieving high sensitivity and efficiency. The range of existing electrochemical methods with carbon electrode displays the highest rate in the development of biosensors. Moreover, modification of electrode surfaces based on nanomaterials is frequently used due to their extraordinary conductivity and surface to volume ratio. Different strategies for modifying electrode surfaces facilitate electron transport between the electrode surface and biomolecules, including DNA, oligonucleotides and their components. This review aims to summarize recent developments in the electrochemical analysis of purine derivatives, as well as discuss different applications.
authors.affiliation: Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic. vimal.shrma@gmail.com.
authors.forename: Vimal Kumar
authors.initials: VK
authors.lastname: Sharma
authors.affiliation: Institute of Biophysics of the Academy of Sciences of the Czech Republic, V.V.I., Kralovopolska 135, CZ-612 65 Brno, Czech Republic. jelen@ibp.cz.
authors.forename: Frantisek
authors.initials: F
authors.lastname: Jelen
authors.affiliation: Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, CZ-625 00 Brno, Czech Republic. libuse@chemi.muni.cz.
authors.forename: Libuse
authors.initials: L
authors.lastname: Trnkova
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D010084:Oxidation-Reduction; D011687:Purines / Q000032:analysis*; D013499:Surface Properties
chemical_list: D011687:Purines; C030985:purine