title: A self-assembled nanopatch with peptide-organic multilayers and mechanical properties.
abstract: Peptides enable the construction of a diversity of one-dimensional (1D) and zero-dimensional (0D) nanostructures by molecular self-assembly. To date, it is a great challenge to construct two-dimensional (2D) nanostructures from peptides. Here we introduce an organic molecule to tune the amphiphilic-like peptide assembly to form a peptide-organic 2D nanopatch structure. The nanomechanical properties of the nanopatch were explored by quantitative nanomechanical imaging and force control manipulation. The peptide-organic patches are multilayers composed of several domains, which can be peeled off stepwise. The patch formation provides an approach towards constructing 2D nanostructures by peptide-organic assembly and it could be potentially utilized in a wide range of applications such as functional biomaterials.
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Centre for DNA Nanotechnology (CDNA), and Department of Physics and Astronomy, Aarhus University, DK 8000 Aarhus C, Denmark. fbe@inano.au.dk dong@inano.au.dk.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Yibao
authors.initials: Y
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Xia
authors.forename: Christian
authors.initials: C
authors.lastname: Bortolini
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Yang
authors.forename: Jan S
authors.initials: JS
authors.lastname: Pedersen
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D006860:Hydrogen Bonding; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D016011:Normal Distribution; D009930:Organic Chemicals / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D009930:Organic Chemicals; D010455:Peptides