title: High correlation of double Debye model parameters in skin cancer detection.
abstract: The double Debye model can be used to capture the dielectric response of human skin in terahertz regime due to high water content in the tissue. The increased water proportion is widely considered as a biomarker of carcinogenesis, which gives rise of using this model in skin cancer detection. Therefore, the goal of this paper is to provide a specific analysis of the double Debye parameters in terms of non-melanoma skin cancer classification. Pearson correlation is applied to investigate the sensitivity of these parameters and their combinations to the variation in tumor percentage of skin samples. The most sensitive parameters are then assessed by using the receiver operating characteristic (ROC) plot to confirm their potential of classifying tumor from normal skin. Our positive outcomes support further steps to clinical application of terahertz imaging in skin cancer delineation.
authors.forename: Bao C Q
authors.initials: BC
authors.lastname: Truong
authors.forename: H D
authors.initials: HD
authors.lastname: Tuan
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Fitzgerald
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Wallace
authors.forename: H T
authors.initials: HT
authors.lastname: Nguyen
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008962:Models, Theoretical; D012372:ROC Curve; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D055068:Terahertz Spectroscopy
chemical_list: D014408:Biomarkers, Tumor