title: Exploring the spectral information of airflow recordings to help in pediatric Obstructive Sleep Apnea-Hypopnea Syndrome diagnosis.
abstract: This work aims at studying the usefulness of the spectral information contained in airflow (AF) recordings in the context of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) in children. To achieve this goal, we defined two spectral bands of interest related to the occurrence of apneas and hypopneas. We characterized these bands by extracting six common spectral features from each one. Two out of the 12 features reached higher diagnostic ability than the 3% oxygen desaturation index (ODI3), a clinical parameter commonly used as screener for OSAHS. Additionally, the stepwise logistic regression (SLR) feature-selection algorithm showed that the information contained in the two bands was complementary, both between them and with ODI3. Finally, the logistic regression method involving spectral features from the two bands, as well as ODI3, achieved high diagnostic performance after a bootstrap validation procedure (84.6±9.6 sensitivity, 87.2±9.1 specificity, 85.8±5.2 accuracy, and 0.969±0.03 area under ROC curve). These results suggest that the spectral information from AF is helpful to detect OSAHS in children.
authors.forename: Gonzalo C
authors.initials: GC
authors.lastname: Gutierrez-Tobal
authors.forename: Daniel
authors.initials: D
authors.lastname: Alvarez
authors.forename: M Luz
authors.initials: ML
authors.lastname: Alonso
authors.forename: Joaquin
authors.initials: J
authors.lastname: Teran
authors.forename: Felix
authors.initials: F
authors.lastname: Del Campo
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
mesh_terms: D000293:Adolescent; D000465:Algorithms; D001049:Apnea; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D010100:Oxygen; D017286:Polysomnography / Q000379:methods; D012372:ROC Curve; D015203:Reproducibility of Results; D012119:Respiration; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis*
chemical_list: D010100:Oxygen