title: The serum levels of malondialdehyde, vitamin e and erythrocyte catalase activity in psoriasis patients.
abstract: BACKGROUND
  Psoriasis is a common skin disease which is characterized by increased epidermal proliferation and dermal inflammation affecting 0.1-3% of general population. Most of the psoriasis patients are young or middle aged adults, although no age exempted. The oxidative stress develops due to imbalance in oxidants and antioxidants, which was proposed to have role in psoriasis.
  
  
  OBJECTIVE
  The presented research work was planned to evaluate oxidative stress by measuring serum malondialdehyde (MDA) as oxidant and serum vitamin E, erythrocyte catalase (CAT) activity as antioxidants in psoriasis patients.
  
  
  METHODS
  Total 90 clinically diagnosed psoriasis patients of age group of 20 to 60 years and without any drug therapy for preceding two months and 90 matched healthy controls were included in the presented study. The severity of psoriasis was determined by PASI score. The fasting blood sample collected and accessed for serum MDA, serum vitamin E and erythrocyte catalase activity.
  
  
  RESULTS
  The study results were compiled and statistical analysis was done using students t-test. Our results showed significantly increased levels of serum MDA (p<0.001) and significantly decreased serum vitamin E (p<0.001) as well as erythrocyte catalase activity (p<0.001) in psoriasis patients as compared to controls.
  
  
  CONCLUSIONS
  The presented study concluded the oxidative stress in psoriasis, indicated by increased serum MDA and decreased Vitamin E, erythrocyte catalase activity. Our study also supports the possibility of involvement of oxidative stress in pathogenesis of psoriasis.
authors.affiliation: Associate Professor Department of Biochemistry, RIMS , Raichur, Karnataka, India .
authors.forename: Vijaykumar M
authors.initials: VM
authors.lastname: Pujari
authors.affiliation: Associate Professor, Deparment of Skin and V D, RIMS , Raichur, Karnataka, India .
authors.forename: Shankargouda
authors.initials: S
authors.lastname: Ireddy
authors.affiliation: Associate Professor Department of Pathology, RIMS , Raichur, Karnataka, India .
authors.forename: Inderraj
authors.initials: I
authors.lastname: Itagi
authors.affiliation: Associate Professor Department of Ophthalmology, RIMS , Raichur, Karnataka, India .
authors.forename: Siddesh
authors.initials: S
authors.lastname: Kumar H
keywords: Catalase; MDA; Oxidative stress; Psoriasis; Vitamin E