title: Ciprofloxacin release using natural rubber latex membranes as carrier.
abstract: Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.
authors.forename: Heitor
authors.initials: H
authors.lastname: Dias Murbach
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.
authors.forename: Guilherme
authors.identifier: 0000-0002-3275-6545
authors.initials: G
authors.lastname: Jaques Ogawa
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil ; Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Azevedo Borges
authors.affiliation: Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil.
authors.forename: Matheus Carlos
authors.initials: MC
authors.lastname: Romeiro Miranda
authors.affiliation: Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil.
authors.forename: Rute
authors.initials: R
authors.lastname: Lopes
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil ; Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil.
authors.forename: Natan
authors.initials: N
authors.lastname: Roberto de Barros
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.
authors.forename: Alexandre Vinicius
authors.initials: AV
authors.lastname: Guedes Mazalli
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.
authors.forename: Rosângela
authors.initials: R
authors.lastname: Gonçalves da Silva
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil.
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Ferreira Cinman
authors.affiliation: Physics Department, Faculty of Sciences, São Paulo State University, 14-01 Engenheiro Luiz Edmundo Carrijo Coube Avenue, 17033-360 Bauru, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: de Camargo Drago
authors.affiliation: Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil ; Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil.
authors.forename: Rondinelli
authors.initials: R
authors.lastname: Donizetti Herculano