title: Synthesis and function of phospholipids in Staphylococcus aureus.
abstract: Phospholipids are the major components of bacterial membranes, and changes in phospholipid composition affect important cellular processes such as metabolism, stress response, antimicrobial resistance, and virulence. The most prominent phospholipids in Staphylococcus aureus are phosphatidylglycerol, lysyl-phosphatidylglycerol, and cardiolipin, whose biosynthesis is mediated by a complex protein machinery. Phospholipid composition of the staphylococcal membrane has to be continuously adjusted to changing external conditions, which is achieved by a series of transcriptional and biochemical regulatory mechanisms. This mini-review outlines the current state of knowledge concerning synthesis, regulation, and function of the major staphylococcal phospholipids.
authors.affiliation: University of Tübingen, Interfaculty Institute of Microbiology and Infection Medicine, Cellular and Molecular Microbiology Division, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kuhn
authors.affiliation: University of Tübingen, Interfaculty Institute of Microbiology and Infection Medicine, Cellular and Molecular Microbiology Division, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Slavetinsky
authors.affiliation: University of Tübingen, Interfaculty Institute of Microbiology and Infection Medicine, Cellular and Molecular Microbiology Division, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany. Electronic address: andreas.peschel@med.uni-tuebingen.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Peschel
mesh_terms: D053898:Biosynthetic Pathways / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D010743:Phospholipids / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism*
chemical_list: D010743:Phospholipids
keywords: Cardiolipin; Lysyl-phosphatidylglycerol; Membrane; Phosphatidylglycerol; Phospholipids; Staphylococcus aureus