title: Comparison of clustering pipelines for the analysis of mass spectrometry imaging data.
abstract: Mass spectrometry imaging (MSI) is valuable for biomedical applications because it links molecular and morphological information. However, MSI datasets can be very large, and analyzing them to identify important biological patterns is a challenging computational problem. Many types of unsupervised analysis have been applied to MSI data, and in particular, clustering has recently gained attention for this application. In this paper, we present an exploratory study of the performance of different analysis pipelines using k-means and fuzzy k-means clustering. The results indicate the effects of different pre-processing and parameter selections on identifying biologically relevant patterns in MSI data.
authors.forename: Sanaiya
authors.initials: S
authors.lastname: Sarkari
authors.forename: Chanchala D
authors.initials: CD
authors.lastname: Kaddi
authors.forename: Rachel V
authors.initials: RV
authors.lastname: Bennett
authors.forename: Facundo M
authors.initials: FM
authors.lastname: Fernandez
authors.forename: May D
authors.initials: MD
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D016000:Cluster Analysis; D051379:Mice; D025341:Principal Component Analysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization