title: Modulation of charge transport across double-stranded DNA by the site-specific incorporation of copper bis-phenanthroline complexes.
abstract: The site-specific incorporation of transition-metal complexes within DNA duplexes, followed by their immobilization on a gold surface, was studied by electrochemistry to characterize their ability to mediate charge. Cyclic voltammetry, square-wave voltammetry, and control experiments were carried out on fully matched and mismatched DNA strands that are mono- or bis-labeled with transition-metal complexes. These experiments are all consistent with the ability of the metal centers to act as a redox probe that is well coupled to the DNA π-stack, allowing DNA-mediated charge transport.
authors.affiliation: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Dauphin-Ducharme
authors.forename: Fiora
authors.initials: F
authors.lastname: Rosati
authors.forename: Andrea
authors.initials: A
authors.lastname: Greschner
authors.forename: A Dowine
authors.initials: AD
authors.lastname: De Bruijn
authors.forename: Danielle
authors.initials: D
authors.lastname: Salvatore
authors.forename: Violeta
authors.initials: V
authors.lastname: Toader
authors.forename: Kai Lin
authors.initials: KL
authors.lastname: Lau
authors.forename: Janine
authors.initials: J
authors.lastname: Mauzeroll
authors.forename: Hanadi
authors.initials: H
authors.lastname: Sleiman
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D004579:Electron Transport; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010618:Phenanthrolines; D004247:DNA; C025205:1,10-phenanthroline