title: Functional brain connectivity phenotypes for schizophrenia drug discovery.
abstract: While our knowledge of the pathophysiology of schizophrenia has increased dramatically, this has not translated into the development of new and improved drugs to treat this disorder. Human brain imaging and electrophysiological studies have provided dramatic new insight into the mechanisms of brain dysfunction in the disease, with a swathe of recent studies highlighting the differences in functional brain network and neural system connectivity present in the disorder. Only recently has the value of applying these approaches in preclinical rodent models relevant to the disorder started to be recognised. Here we highlight recent findings of altered functional brain connectivity in preclinical rodent models and consider their relevance to those alterations seen in the brains of schizophrenia patients. Furthermore, we highlight the potential translational value of using the paradigm of functional brain connectivity phenotypes in the context of preclinical schizophrenia drug discovery, as a means both to understand the mechanisms of brain dysfunction in the disorder and to reduce the current high attrition rate in schizophrenia drug discovery.
authors.affiliation: Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK n.dawson1@lancaster.ac.uk.
authors.forename: Neil
authors.initials: N
authors.lastname: Dawson
authors.affiliation: Institute of Neuroscience and Psychology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING), University of Glasgow, Glasgow, UK.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Morris
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK Psychiatric Research Institute of Neuroscience in Glasgow (PsyRING), University of Glasgow, Glasgow, UK.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Pratt
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D009434:Neural Pathways / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*
keywords: EEG; NMDA receptor; default mode network; fMRI; genetic risk factors; graph theory; hippocampal-prefrontal connectivity; thalamic connectivity