title: Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets.
abstract: A genome-wide association study of gout in European populations identified 12 genetic variants strongly associated with risk of gout, but it is unknown whether these variants are also associated with gout risk in Chinese populations. A total of 145 patients with gout and 310 healthy control patients were recruited for a case-control association study. Twelve SNPs of CLNK and ZNF518B gene were genotyped, and association analysis was performed. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the association. Overall, we found four risk alleles for gout in patients: the allele "G" of rs2041215 and rs1686947 in the CLNK gene by dominant model (OR 1.66; 95 % CI 1.04-2.63; p = 0.031) (OR 2.19; 95 % CI 1.38-3.46; p = 0.001) and additive model (OR 1.39; 95 % CI 1.00-1.93; p = 0.049) (OR 1.67; 95 % CI 1.19-2.32; p = 0.003), respectively, and the allele "A" of rs10938799 and rs10016022 in ZNF518B gene by recessive model (OR 4.66; 95 % CI 1.44-15.09; p = 0.008) (OR 4.54; 95 % CI 1.23-16.76; p = 0.020). Further haplotype analysis showed that the TCATTCTGA haplotype of CLNK was more frequent among patients with gout (adjusted OR 0.48; 95 % CI 0.24-0.95; p = 0.036). Additionally, polymorphisms of rs2041215, rs10938799, and rs17467273 were also correlated with clinical pathological parameters. This study provides evidence for gout susceptibility genes, CLNK and ZNF518B, in a Chinese population, which may have potential as diagnostic and prognostic marker for gout patients.
authors.affiliation: Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, Xianyang, 712082, Shaanxi, China.
authors.forename: Tian-Bo
authors.initials: TB
authors.lastname: Jin
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Ren
authors.forename: Xugang
authors.initials: X
authors.lastname: Shi
authors.forename: Mutu
authors.initials: M
authors.lastname: Jiri
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.forename: Dongya
authors.initials: D
authors.lastname: Yuan
authors.forename: Longli
authors.initials: L
authors.lastname: Kang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D018609:Tibet / Q000453:epidemiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C411024:CLNK protein, human; D005819:Genetic Markers