title: A case of acute kidney injury from crystal nephropathy secondary to pomalidomide and levofloxacin use.
abstract: Pomalidomide is an analog of thalidomide with immunomodulatory, anti-angiogenic, and anti-neoplastic activity indicated for the treatment of multiple myeloma refractory to at least two prior therapies. The incidence for renal failure was <5% in a single phase II study of pomalidomide and dexamethasone in patients with multiple myeloma that failed both lenalidomide and bortezomib therapy. We report a case suggesting crystal nephropathy as the mechanism for acute kidney injury in pomalidomide and fluoroquinolone use.
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Phylicia
authors.initials: P
authors.lastname: Baird
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA Division of Kidney Diseases and Hypertension, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Leung
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Huy
authors.initials: H
authors.lastname: Hoang
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Olawumi
authors.initials: O
authors.lastname: Babalola
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA North Shore LIJ Cancer Institute and the Division of Hematology/Oncology, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Devoe
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA Division of Kidney Diseases and Hypertension, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA.
authors.forename: Rimda
authors.initials: R
authors.lastname: Wanchoo
authors.affiliation: Department of Internal Medicine, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA Division of Kidney Diseases and Hypertension, Hofstra North Shore - LIJ School of Medicine, Great Neck, NY, USA kdj200@gmail.com.
authors.forename: Kenar D
authors.initials: KD
authors.lastname: Jhaveri
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D064704:Levofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D013792:Thalidomide; D064704:Levofloxacin; C467566:pomalidomide
keywords: Onconephrology; crystal nephropathy; myeloma; pomalidomide; renal failure