title: Acute ischaemic stroke and myocardial infarction after chemotherapy with vinorelbine for non-small cell lung cancer: a case report.
abstract: Vinorelbine is an important chemotherapeutic agent which is used in metastatic non-small cell lung cancer. Case reports have described the occurrence of acute cardiac ischaemic events as a side effect. It has not been established whether the suspected mechanisms for cardiac ischaemia might also cause other vascular events. We report about a 70-year-old male with metastatic non-small cell lung cancer who received vinorelbine as an outpatient. The patient presents with a cardiovascular risk profile. He was admitted to the hospital 3 days later with acute left-sided hemiplegia and hemianopia. Brain computed tomography (CT) demonstrated acute right hemispheric ischaemic stroke. Nine days after admission, the patient additionally suffered ST elevation myocardial infarction. A coronary angiogram demonstrated high grade stenosis of the right coronary artery treated with two bare-metal stents. Caution should be noted in patients who present with a cardiovascular risk profile as they might be vulnerable experiencing acute ischaemic events.
authors.affiliation: a Department of Neurology , University Hospital Carl Gustav Carus , Dresden , Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Zerna
authors.affiliation: b Heart Centre, Department of Internal Medicine and Cardiology , University Hospital Carl Gustav Carus , Dresden , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Guenther
authors.affiliation: c University Cancer Center, University Hospital Carl Gustav Carus , Dresden , Germany.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Folprecht
authors.affiliation: a Department of Neurology , University Hospital Carl Gustav Carus , Dresden , Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Puetz
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000453:epidemiology; D015897:Comorbidity; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D058729:Peripheral Arterial Disease / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking; D020521:Stroke / Q000139:chemically induced*; D014747:Vinblastine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine
keywords: Cardiovascular risk profile; Metastatic non-small cell lung cancer; Myocardial infarction; Stroke; Vinorelbine