title: Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(II) complex that can be photolyzed by visible light.
abstract: We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(II)-dependent peptide nucleases.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. eugenio.vazquez@usc.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.forename: Mateo I
authors.initials: MI
authors.lastname: Sánchez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
authors.forename: M
authors.initials: M
authors.lastname: Eugenio Vázquez
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry; D006639:Histidine / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D010782:Photolysis / Q000528:radiation effects*
chemical_list: D009942:Organometallic Compounds; D010455:Peptides; C103599:bis(bipyridyl)ruthenium(II); D006639:Histidine; D015082:2,2'-Dipyridyl