title: Dermatomyositis as a presentation of neuromyelitis optica spectrum disorder.
abstract: OBJECTIVE
  This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM).
  
  
  METHODS
  A 40year-old Caucasian female presented with 6months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate.
  
  
  CONCLUSIONS
  We recommend considering NMOSD in the differential diagnosis of patients with DM and other autoimmune disorders that also present with clinical signs of myelopathy.
authors.affiliation: Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA.
authors.forename: David
authors.initials: D
authors.lastname: Delman
authors.affiliation: Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA.
authors.forename: Xianming
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Dermatology, 414 Mary Ellen Jones Building, Chapel Hill, NC 27599, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Zedek
authors.affiliation: Department of Radiology, 101 Manning Drive, Chapel Hill, NC 37514, USA.
authors.forename: Valerie
authors.initials: V
authors.lastname: Jewells
authors.affiliation: Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA.
authors.forename: Nizar
authors.initials: N
authors.lastname: Chahin
authors.affiliation: Department of Neurology, 170 Manning Drive, Physician Office Building, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, Mary Ellen Jones Building, Chapel Hill, NC 27599, USA. Electronic address: markovic@email.unc.edu.
authors.forename: Silva
authors.initials: S
authors.lastname: Markovic-Plese
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D053487:DEAD-box RNA Helicases / Q000276:immunology; D003882:Dermatomyositis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D008279:Magnetic Resonance Imaging; D009471:Neuromyelitis Optica / Q000503:physiopathology*; D012867:Skin / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology
chemical_list: D000906:Antibodies; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1
keywords: Dermatomyositis; MDA5 antibody; Neuromyelitis optica