title: The BCL2 antagonist ABT-199 triggers apoptosis, and augments ibrutinib and idelalisib mediated cytotoxicity in CXCR4 Wild-type and CXCR4 WHIM mutated Waldenstrom macroglobulinaemia cells.
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Pathology, Boston University Medical Center, Boston, MA, USA.|Theagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Hunter
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Lian
authors.initials: L
authors.lastname: Xu
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Nickolas
authors.initials: N
authors.lastname: Tsakmaklis
authors.affiliation: Department of Pathology, Boston University Medical Center, Boston, MA, USA.|Theagenio Cancer Hospital, Thessaloniki, Greece.
authors.forename: Evdoxia
authors.initials: E
authors.lastname: Hatjiharissi
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Kanan
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Davids
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA.|Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Boston, MA, USA. steven_treon@dfci.harvard.edu.|Department of Medicine, Harvard Medical School, Boston, MA, USA. steven_treon@dfci.harvard.edu.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Treon
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000378:metabolism; D000072224:Bcl-2-Like Protein 11; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D010880:Piperidines; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D011687:Purines / Q000008:administration & dosage / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D052999:Quinazolinones / Q000008:administration & dosage / Q000494:pharmacology*; D019718:Receptors, CXCR4 / Q000235:genetics* / Q000378:metabolism; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; D019086:Bridged Bicyclo Compounds, Heterocyclic; C527276:CXCR4 protein, human; D008565:Membrane Proteins; D010880:Piperidines; D011518:Proto-Oncogene Proteins; D011687:Purines; D011720:Pyrazoles; D011743:Pyrimidines; D052999:Quinazolinones; D019718:Receptors, CXCR4; D013449:Sulfonamides; C551803:ibrutinib; D000225:Adenine; C579720:venetoclax; C552946:idelalisib
keywords: ABT-199; BCL2; CXCR4; Ibrutinib; Waldenström macroglobulinemia