title: Multi-site cyclization via initial C-H activation using a rhodium(III) catalyst: rapid assembly of frameworks containing indoles and indolines.
abstract: Tandem multi-site cyclization triggered by Rh(iii)-catalyzed C-H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[a]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). In particular, the synthesis of pseudo-indoxyl is typically completed within 10 min, and the reaction tolerates air, water and a range of solvents.
authors.affiliation: Key laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. dongl@scu.edu.cn.
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Huang
authors.forename: Liu
authors.initials: L
authors.lastname: Qin
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Song
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D007211:Indoles; C057812:indoline; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium