title: A novel poly(γ-glutamic acid)/silk-sericin hydrogel for wound dressing: Synthesis, characterization and biological evaluation.
abstract: A novel multifunctional poly(γ-glutamic acid)/silk sericin (γ-PGA/SS) hydrogel has been developed and used as wound dressing. The physical and chemical properties of the γ-PGA/SS gels were systemically investigated. Furthermore, these γ-PGA/SS gels have been found to promote the L929 fibroblast cells proliferate, and in the in vivo study, significant stimulatory effects were also observed on granulation and capillary formation on day 9 in H-2-treated wounds, indicating that this new complex hydrogel could maintain a moist healing environment, protect the wound from bacterial infection, absorb excess exudates, and promote cell proliferation to reconstruct damaged tissue. Considering the simple preparation process and excellent biological property, this γ-PGA/SS hydrogel might have a wide range of applications in biomedical and clinical areas.
authors.affiliation: Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Shi
authors.affiliation: Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China. Electronic address: summer_ningzi@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.affiliation: Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China. Electronic address: chenlis@tjpu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Tianjin Key Laboratory of Artificial Cell, Tianjin Third Central Hospital, Tianjin 300170, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Artificial Cell, Tianjin Third Central Hospital, Tianjin 300170, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000818:Animals; D001684:Biological Dressings; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D011099:Polyglutamic Acid / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D047030:Sericins / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D047030:Sericins; D011099:Polyglutamic Acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Hydrogel; Poly(γ-glutamic acid); Silk sericin; Wound dressing