title: Evaluation of silica nanoparticle toxicity after topical exposure for 90 days.
abstract: Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Ryu
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Nak-won
authors.initials: NW
authors.lastname: Seong
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Byoung Joon
authors.initials: BJ
authors.lastname: So
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Heung-sik
authors.initials: HS
authors.lastname: Seo
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Jun-ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Jeong-Sup
authors.initials: JS
authors.lastname: Hong
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Myeong-kyu
authors.initials: MK
authors.lastname: Park
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Min-Seok
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Yu-Ri
authors.initials: YR
authors.lastname: Kim
authors.affiliation: Department of Clinical Laboratory Science, Shinheung College, Uijeongbu, South Korea.
authors.forename: Kyu-Bong
authors.initials: KB
authors.lastname: Cho
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Mu Yeb
authors.initials: MY
authors.lastname: Seo
authors.affiliation: Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Meyoung-Kon
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Korea Testing and Research Institute, Gyunggi-Do, South Korea.
authors.forename: Eun Ho
authors.initials: EH
authors.lastname: Maeng
authors.affiliation: Department of Dermatology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Son
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004781:Environmental Exposure / Q000032:analysis*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D036401:Toxicity Tests, Chronic
chemical_list: D012822:Silicon Dioxide
keywords: dermal route; silica nanoparticles; toxicity