title: Phytochemical Screening and Evaluation of Analgesic Activity of Oroxylum indicum.
abstract: We aimed to study phytochemical screening and analgesic activity of ethanol extract of Oroxylum indicum. The dried powder of the barks of the plant was extracted with 95% ethanol and was subjected to various phytochemical tests to ascertain the principle constituents contained in the extract. The result revealed the presence of alkaloids, flavonoids, tannins, glycosides in the ethanol extract of Oroxylum indicum. The extract was screened for analgesic activity by using hot plate, acetic acid-induced writhing and formalin test. The ethanol extract of the plant at two different doses (250 and 500 mg/kg) showed significant (P<0.05) analgesic effect in all test methods (hot plate, acetic acid-induced writhing and formalin). The analgesic activity was compared with a standard drug (ketorolac at 10 mg/kg). Based on the present findings and previous literature review it can be concluded that flavonoids and tannins might be responsible for the analgesic activity. We suggest that ethanol extract of Oroxylum indicum might have potential chemical constituents that could be used in the future for the development of novel analgesic agent.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
authors.forename: B K
authors.initials: BK
authors.lastname: Das
authors.affiliation: Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.
authors.forename: M M
authors.initials: MM
authors.lastname: Al-Amin
authors.affiliation: Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.
authors.forename: S M
authors.initials: SM
authors.lastname: Russel
authors.affiliation: Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.
authors.forename: S
authors.initials: S
authors.lastname: Kabir
authors.affiliation: Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.
authors.forename: R
authors.initials: R
authors.lastname: Bhattacherjee
authors.affiliation: Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka 1229, Bangladesh.
authors.forename: J M A
authors.initials: JM
authors.lastname: Hannan
keywords: Oroxylum indicum; analgesic activity; ethanol extract; phytochemical