title: Age and gender specific biokinetic model for strontium in humans.
abstract: A biokinetic model for strontium in humans is necessary for quantification of internal doses due to strontium radioisotopes. The ICRP-recommended biokinetic model for strontium has limitations for use in a population study, because it is not gender specific and does not cover all age ranges. The extensive Techa River data set on (90)Sr in humans (tens of thousands of measurements) is a unique source of data on long-term strontium retention for men and women of all ages at intake. These, as well as published data, were used for evaluation of age- and gender-specific parameters for a new compartment biokinetic model for strontium (Sr-AGe model). The Sr-AGe model has a similar structure to the ICRP model for the alkaline earth elements. The following parameters were mainly re-evaluated: gastrointestinal absorption and parameters related to the processes of bone formation and resorption defining calcium and strontium transfers in skeletal compartments. The Sr-AGe model satisfactorily describes available data sets on strontium retention for different kinds of intake (dietary and intravenous) at different ages (0-80 years old) and demonstrates good agreement with data sets for different ethnic groups. The Sr-AGe model can be used for dose assessment in epidemiological studies of general populations exposed to ingested strontium radioisotopes.
authors.affiliation: Urals Research Center for Radiation Medicine, Chelyabinsk 454076, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Shagina
authors.forename: E I
authors.initials: EI
authors.lastname: Tolstykh
authors.forename: M O
authors.initials: MO
authors.lastname: Degteva
authors.forename: L R
authors.initials: LR
authors.lastname: Anspaugh
authors.forename: B A
authors.initials: BA
authors.lastname: Napier
mesh_terms: D000375:Aging / Q000378:metabolism*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity / Q000502:physiology; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D012727:Sex Characteristics; D013324:Strontium / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
chemical_list: D013324:Strontium