title: Plasma levels of alarmin IL-33 are unchanged in autism spectrum disorder: a preliminary study.
abstract: The pathogenesis of autism spectrum disorder (ASD) is unknown, and the immune system has been appointed to play an important role. The interleukin 33 (IL-33), a member of the IL-1, may act as an alarmin. This study aimed to evaluate plasma levels of IL-33, sST2, and IL-1β in 30 patients with ASD in comparison with 18 controls matched by gender, age and maternal age at childbirth. Patients did not differ from controls in IL-33, sST2, and IL-1β plasma levels. Alarmin levels were not correlated with age, and neither was influenced by clinical parameters. Our results undermine the role of IL-33/ST2 in ASD.
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil. Electronic address: izabelagb@gmail.com.
authors.forename: Izabela Guimarães
authors.initials: IG
authors.lastname: Barbosa
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Federal University of Juiz de Fora, Governador Valadares, Brazil.
authors.forename: David Henrique
authors.initials: DH
authors.lastname: Rodrigues
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Natália Pessoa
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Larissa Fonseca da Cunha
authors.initials: LF
authors.lastname: Sousa
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Erica Leandro M
authors.initials: EL
authors.lastname: Vieira
authors.affiliation: Pediatric Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões-E-Silva
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Pediatric Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kummer
authors.affiliation: Neuroscience Branch, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil. Electronic address: altexr@gmail.com.
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053583:Interleukin-1beta / Q000097:blood; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011956:Receptors, Cell Surface / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053583:Interleukin-1beta; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface
keywords: Autism; Cytokines; IL-1β; IL-33; sST2