title: Evolution of acidic Ca²⁺ stores and their resident Ca²⁺-permeable channels.
abstract: Acidic Ca(2+) stores refer to a collection of H(+)- and Ca(2+)-rich organelles involved in Ca(2+) signalling across taxonomic kingdoms. They include lysosomes, lysosome-related organelles, secretory vesicles, vacuoles and acidocalcisomes. Acidic Ca(2+) stores express several types of Ca(2+)-permeable channels belonging to the TRP, TPC, P2X and IP3/ryanodine receptor families. The channels have distinct phylogenomic profiles, and each acidic Ca(2+) store possesses a distinct Ca(2+) channel portfolio. The functions of acidic Ca(2+) stores appear to be conserved in processes such as signalling, membrane traffic and "auto-secretion". Thus, despite substantial variation in form, acidic Ca(2+) stores may function similarly across the natural world.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: patel.s@ucl.ac.uk.
authors.forename: Sandip
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Xinjiang
authors.initials: X
authors.lastname: Cai
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology*; D006801:Humans; D010802:Phylogeny
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Acidic Ca(2+) stores; Acidocalcisomes; Evolution; IP(3) receptor; LRRK2; Lysosome-related organelles; Lysosomes; Membrane traffic; Mucolipin; NAADP; P2X4; Ryanodine receptor; Secretion; Secretory vesicles; TPC; TRP; Vacuoles