title: The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ.
abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality. Mutations in C6ORF105, associated with decreased gene expression, positively correlate with the risk of CAD in Chinese populations. Moreover, the C6ORF105-encoded protein may play a role in coagulation. Here, we report that C6ORF105 gene expression is lower in circulating mononuclear cells from obese diabetic than lean subjects. Moreover, C6ORF105 is expressed in human macrophages and atherosclerotic lesions, where its expression positively correlates with expression of the transcription factor Peroxisome Proliferator-Activated Receptor (PPAR)γ. Activation of PPARγ increases, in a PPARγ-dependent manner, the expression of C6ORF105 in human macrophages and atherosclerotic lesions.
authors.affiliation: Université Lille 2, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France.
authors.forename: G
authors.initials: G
authors.lastname: Chinetti-Gbaguidi
authors.affiliation: Université Lille 2, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Copin
authors.affiliation: Université Lille 2, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Derudas
authors.affiliation: Université Lille 2, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Vanhoutte
authors.affiliation: Université Lille 2, F-59000 Lille, France; Centre Hospitalier Régional Universitaire de Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Zawadzki
authors.affiliation: Université Lille 2, F-59000 Lille, France; Centre Hospitalier Régional Universitaire de Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Jude
authors.affiliation: Centre Hospitalier Régional Universitaire de Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Haulon
authors.affiliation: Université Lille 2, F-59000 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France; Centre Hospitalier Régional Universitaire de Lille, France; Department of Endocrine Surgery, University Hospital, F-59000 Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Pattou
authors.affiliation: Department of Internal Medicine I, University Hospital Aachen, D-52074 Aachen, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Marx
authors.affiliation: Université Lille 2, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France; European Genomic Institute for Diabetes (EGID), FR 3508, F-59000 Lille, France. Electronic address: bart.staels@pasteur-lille.fr.
authors.forename: B
authors.initials: B
authors.lastname: Staels
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D009765:Obesity / Q000378:metabolism; D047495:PPAR gamma / Q000502:physiology*; D015533:Transcriptional Activation
chemical_list: C568706:ADTRP protein, human; D008565:Membrane Proteins; D047495:PPAR gamma
keywords: Atherosclerosis; Gene regulation; Macrophage; Transcription factor