title: Novel therapies for open-angle glaucoma.
abstract: Open-angle glaucoma is a multifactorial optic neuropathy characterized by progressive loss of retinal ganglion cells and their axons. It is an irreversible disease with no established cure. The only currently approved treatment is aimed at lowering intraocular pressure, the most significant risk factor known to date. However, it is now clear that there are other risk factors involved in glaucoma's pathophysiology. To achieve future improvements in glaucoma management, new approaches to therapies and novel targets must be developed. Such therapies may include new tissue targets for lowering intraocular pressure, molecules influencing ocular hemodynamics, and treatments providing neuroprotection of retinal ganglion cells. Furthermore, novel drug delivery systems are in development that may improve patient compliance, increase bioavailability, and decrease adverse side effects.
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Wentz
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Nathaniel J
authors.initials: NJ
authors.lastname: Kim
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Wang
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Annahita
authors.initials: A
authors.lastname: Amireskandari
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
authors.affiliation: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine 1160 W Michigan St, Indianapolis, IN 46202 USA.
authors.forename: Alon
authors.initials: A
authors.lastname: Harris