title: Essentials in the life process indicated by the self-referential genetic code.
abstract: The self-referential genetic encoding starts with glycine and serine, in the realm of one-carbon units of metabolism. It is proposed that the prototRNA dimer-directed mechanism of protein synthesis and encoding promotes a sink dynamics that corresponds to the driving 'force' for the fixation of the supporting metabolic pathways. A succession of processes is delineated, ending up in reproduction, which accomplished the function of reinforcing the protein synthesis metabolic sink mechanism.
authors.affiliation: Laboratório de Biodiversidade e Evolução Molecular, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270.901, Belo Horizonte, MG, Brazil, romeucardosoguimaraes@gmail.com.
authors.forename: Romeu Cardoso
authors.initials: RC
authors.lastname: Guimarães
mesh_terms: D005075:Biological Evolution; D002244:Carbon / Q000378:metabolism; D002455:Cell Division; D019281:Dimerization; D005815:Genetic Code; D005998:Glycine / Q000737:chemistry* / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000737:chemistry / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008957:Models, Genetic; D000069497:Origin of Life; D014176:Protein Biosynthesis; D012345:RNA, Transfer, Amino Acid-Specific / Q000737:chemistry* / Q000378:metabolism; D012098:Reproduction; D012694:Serine / Q000737:chemistry* / Q000378:metabolism
chemical_list: D012345:RNA, Transfer, Amino Acid-Specific; D012694:Serine; D002244:Carbon; D012696:Glycine Hydroxymethyltransferase; D005998:Glycine