title: Nurse like cells: chronic lymphocytic leukemia associated macrophages.
abstract: CD14 + cells are able to differentiate into large and adherent cells if in contact with chronic lymphocytic leukemia (CLL) cells or healthy B lymphocytes. In CLL these cells, called CLL-nurse like cells (NLCs), express a very high amount of CD163 and CD68 and are able to rescue CLL cells through CCL4 production. Adherent cells derived from healthy donors, called HD-NLCs, express very little CD163 and CD68, do not produce CCL4 and are unable to rescue CCL cells. This study reveals that CLL-NLCs are the specific nurse cells in CLL, protecting CLL cells from death.
authors.affiliation: INSERM UMR1037 - Cancer Research Center of Toulouse , Toulouse , France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Boissard
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Fournié
authors.forename: Camille
authors.initials: C
authors.lastname: Laurent
authors.forename: Mary
authors.initials: M
authors.lastname: Poupot
authors.forename: Loïc
authors.initials: L
authors.lastname: Ysebaert
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism; D015415:Biomarkers; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism* / Q000473:pathology*; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology*
chemical_list: D000954:Antigens, Surface; D015415:Biomarkers
keywords: CD163; Chronic lymphocytic leukemia; nurse like cells; tumor-associated macrophages