title: Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats.
abstract: Multiple small sessile raised lesions were detected on the ventral surface of the tongue in two 13-year-old domestic cats. The lesions were incidental in both cats. Lesions from both cats appeared histologically as well-demarcated foci of markedly thickened folded epithelium that formed keratin-filled shallow cuplike structures. Large keratinocytes that contained a swollen nucleus surrounded by a clear cytoplasmic halo (koilocytes) were common, suggesting a diagnosis of a papillomavirus-induced papillomas, and papillomavirus antigen was demonstrated by immunohistochemistry. The papillomas exhibited diffuse intense cytoplasmic and nuclear immunoreactivity against cyclin-dependent kinase inhibitor 2A protein (also known as p16 or INK4a protein). Felis catus papillomavirus type 1 DNA sequences were amplified from both papillomas. The papillomas resolved in 1 cat within 3 months of diagnosis, while the papillomas were still visible 4 months after diagnosis in the other cat. This is the first evidence that these papillomas are caused by F. catus papillomavirus type 1.
authors.affiliation: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand J.Munday@massey.ac.nz.
authors.forename: J S
authors.initials: JS
authors.lastname: Munday
authors.affiliation: Gribbles Veterinary Ltd, Christchurch, New Zealand.
authors.forename: R A
authors.initials: RA
authors.lastname: Fairley
authors.affiliation: At the Vets, Christchurch, New Zealand.
authors.forename: H
authors.initials: H
authors.lastname: Mills
authors.affiliation: Department of Pathobiology and Diagnostic Investigation / Diagnostic Center for Population and Animal Health, Michigan State University, East Lansing, MI, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kiupel
authors.affiliation: Gribbles Veterinary Ltd, Palmerston North, New Zealand.
authors.forename: B L
authors.initials: BL
authors.lastname: Vaatstra
mesh_terms: D000818:Animals; D001483:Base Sequence; D002371:Cat Diseases / Q000473:pathology / Q000821:virology*; D002415:Cats; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000378:metabolism; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004848:Epithelium / Q000473:pathology; D007150:Immunohistochemistry / Q000662:veterinary; D015603:Keratinocytes / Q000473:pathology; D008297:Male; D009059:Mouth Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D010212:Papilloma / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D004279:DNA, Viral
keywords: cat; felis catus papillomavirus; oral cavity; papilloma; wart