title: Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-β in mice CNS despite unchanged clinical course.
abstract: Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. The factors involved in this heterogeneity remain unclear. The relevance of MOG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. The aim of this study was investigate if 100 or 300 μg of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MOG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. The results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS.
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: Alyria Teixeira
authors.initials: AT
authors.lastname: Dias
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil; Department of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, Brazil.
authors.forename: Sandra Bertelli Ribeiro
authors.initials: SB
authors.lastname: De Castro
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil; Faculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, Teófilo Otoni, Brazil.
authors.forename: Caio César De Souza
authors.initials: CC
authors.lastname: Alves
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: Felipe Pereira
authors.initials: FP
authors.lastname: Mesquita
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: Nathália Stela Visoná
authors.initials: NS
authors.lastname: De Figueiredo
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: Marcilene Gomes
authors.initials: MG
authors.lastname: Evangelista
authors.affiliation: Department of Morphology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
authors.forename: Maria Christina Marques Nogueira
authors.initials: MC
authors.lastname: Castañon
authors.affiliation: Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Juliano
authors.affiliation: IMUNOCET - Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil. Electronic address: ana.paula@ufjf.edu.br.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology; D018925:Chemokines / Q000032:analysis; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000008:administration & dosage*; D013116:Spinal Cord / Q000276:immunology* / Q000473:pathology; D018709:Statistics, Nonparametric
chemical_list: D018925:Chemokines; D063308:Myelin-Oligodendrocyte Glycoprotein
keywords: Animal model; Autoimmunity; Cytokines; MOG(35–55); Multiple sclerosis