title: Mechanisms of the neuromuscular blocking activity of the aminoglycoside antibiotic streptomycin.
abstract: While increasing the spontaneous quantal transmitter release in frog neuromuscular junctions, streptomycin blocked the evoked transmitter release by decreasing the quantal content (m). The quantal parameter of release n (number of release sites) was significantly decreased, while p (probability of release through transmitter activation) increased. Streptomycin competes with calcium ions for the membrane release sites while the intracellular mechanisms of release remain unaffected. The data show a good fit to the two-step hypothesis of quantal transmitter release recently developed on the basis of ouabain actions.
authors.affiliation: Institute for Chemical and Pharmaceutical Research, Iaşi.
authors.forename: D D
authors.initials: DD
authors.lastname: Brănişteanu
authors.forename: A
authors.initials: A
authors.lastname: Sauciuc
authors.forename: B
authors.initials: B
authors.lastname: Proca
authors.forename: A
authors.initials: A
authors.lastname: Fuică
authors.forename: G
authors.initials: G
authors.lastname: Gogescu
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011895:Rana ridibunda; D013307:Streptomycin / Q000494:pharmacology*
chemical_list: D015220:Calcium Channels; D009466:Neuromuscular Blocking Agents; D018377:Neurotransmitter Agents; D010042:Ouabain; D013307:Streptomycin