title: Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel.
abstract: Alternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn-Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH=3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system.
authors.affiliation: Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark; Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil. Electronic address: murillolongo@gmail.com.
authors.forename: Murillo L
authors.initials: ML
authors.lastname: Martins
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil.
authors.forename: Marcos F
authors.initials: MF
authors.lastname: Calabresi
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil.
authors.forename: Caio
authors.initials: C
authors.lastname: Quini
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil.
authors.forename: Juliana F
authors.initials: JF
authors.lastname: Matos
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil.
authors.forename: José R A
authors.initials: JR
authors.lastname: Miranda
authors.affiliation: Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618-970 Botucatu SP, Brazil.
authors.forename: Margarida J
authors.initials: MJ
authors.lastname: Saeki
authors.affiliation: Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.
authors.forename: Heloisa N
authors.initials: HN
authors.lastname: Bordallo
mesh_terms: D000818:Animals; D002482:Cellulose / Q000737:chemistry; D003938:Diagnostic Techniques, Digestive System / Q000295:instrumentation; D016503:Drug Delivery Systems; D005746:Gastric Emptying; D005782:Gels / Q000737:chemistry; D005947:Glucose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007526:Isoelectric Point; D008274:Magnesium / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D060306:Magnetometry / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008422:Materials Testing; D017208:Rats, Wistar; D015032:Zinc / Q000737:chemistry
chemical_list: D005782:Gels; D058185:Magnetite Nanoparticles; D002482:Cellulose; D008274:Magnesium; D005947:Glucose; D015032:Zinc
keywords: Alternate current biosusceptometry; Bio-magnetic materials; Cellulose; Dextrose; Gastric emptying; Muco-adhesive gel