title: Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example.
abstract: Many studies have demonstrated that genotype (G) interacts with adverse life experiences (E) to produce individual differences in vulnerability and resilience to mental disorders, including schizophrenia. Genetic susceptibility to stress and the timing of the environmental exposure(s) are relevant for these interactions and represent common risk factors. We take the example of the FKBP5 gene to illustrate G × E interactions that predict pleiotropic psychiatric outcomes, including schizophrenia.
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY; Mental Health Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY; nikolaos.daskalakis@mssm.edu.
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Daskalakis
authors.affiliation: Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
authors.forename: Elisabeth B
authors.initials: EB
authors.lastname: Binder
mesh_terms: D059647:Gene-Environment Interaction; D006801:Humans; D008016:Life Change Events; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics*; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5