title: Desmoid tumors in neurosurgery: a review of the literature.
abstract: Desmoid tumors (DTs) are rare myofibroblastic neoplasms, which are mostly sporadic, but sometimes associated with familial adenomatous polyposis syndrome. Neurosurgical cases of DT have been very scarce. We review the literature concerning neurosurgical DTs and describe the first case of a cicatricial DT after the resection of vestibular schwannoma, presenting as a painful swelling in the retrosigmoid scar. Contrary to other localizations in the body, standard-of-care wide margin resection cannot be performed in intracranial and spinal DTs. Therefore, maximally safe resection followed by radiotherapy when tumor margins are not free can be proposed as a treatment strategy in neurosurgical DTs.
authors.affiliation: Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium. Electronic address: philippedevloo@gmail.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: De Vloo
authors.affiliation: Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: De Vlieger
authors.affiliation: Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vander Poorten
authors.affiliation: Department of Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Raf
authors.initials: R
authors.lastname: Sciot
authors.affiliation: Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Johannes
authors.initials: J
authors.lastname: van Loon
authors.affiliation: Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Van Calenbergh
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D018222:Desmoid Tumors / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures
keywords: Aggressive fibromatosis; Cicatricial; Desmoid tumor; Desmoid-type fibromatosis