title: Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients.
abstract: This retrospective study was designed to assess statin effects on T-cell activation from HIV-infected individuals. Peripheral blood mononuclear cells from antiretroviral therapy suppressed HIV-infected individuals receiving atorvastatin or pravastatin were evaluated for T-cell activation, exhaustion and function. Atorvastatin was associated with a significant reduction in CD8 T-cell activation (HLA-DR, CD38/HLA-DR) and exhaustion (TIM-3, TIM-3/PD-1) whereas pravastatin had no effect. In contrast, pravastatin increased antigen specific interferon γ production. These results suggest a differential effect of statins on immune activation and function.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Edgar Turner
authors.initials: ET
authors.lastname: Overton
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Sterrett
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Andrew O
authors.initials: AO
authors.lastname: Westfall
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Kahan
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Greer
authors.initials: G
authors.lastname: Burkholder
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Zajac
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.|Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Goepfert
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294 USA.
authors.forename: Anju
authors.initials: A
authors.lastname: Bansal
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000069059:Atorvastatin; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007371:Interferon-gamma / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D017035:Pravastatin / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D012189:Retrospective Studies; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D044966:Anti-Retroviral Agents; D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D007155:Immunologic Factors; D011758:Pyrroles; D007371:Interferon-gamma; D000069059:Atorvastatin; D017035:Pravastatin