title: A review on the effects of PBDEs on thyroid and reproduction systems in fish.
abstract: The objective of this review was to summarize and discuss the effects of Polybrominated diphenyl ethers (PBDEs) on thyroid and reproduction systems in fish. We reviewed the evidences and mechanisms for PBDEs-induced thyroid and reproduction disruption, as well as the cross-talk between the two systems in fish. In thyroid disruption, we mainly paid attention to the effects of PBDEs on hypothalamic-pituitary-thyroid (HPT) axis, thyroid hormones (THs) transport and metabolism, thyroid receptors (TRs) and thyroid follicle histology. In reproduction disruption, we focused on the effects of PBDEs on steroid hormone production, expression of genes involved in steroidogenesis, and gonadal development. Despite that there is an interaction between thyroid and reproductive systems in fish, it is still remains unclear that PBDE-induced reproductive impairments are caused by direct effects on hypothalamic-pituitary-gonadal (HPG) functioning or by indirect action through cross-talk between the two systems. Future studies are needed to explore the relationships between reproductive toxicity and thyroid system disruption after PBDEs exposure.
authors.affiliation: College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Yu
authors.affiliation: Nanjing Institute of Environmental Sciences, MEP, Nanjing, Jiangsu 210042, China. Electronic address: njauhan@163.com.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Han
authors.affiliation: College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address: liuchunshengidid@126.com.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D005399:Fishes / Q000378:metabolism*; D006066:Gonads / Q000378:metabolism*; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D012098:Reproduction; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D055768:Halogenated Diphenyl Ethers; D013963:Thyroid Hormones
keywords: Cross-talk; Fish; PBDEs; Reproductive system; Thyroid system