title: Common TLR5 mutations control cancer progression.
abstract: The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Pfirschke
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Garris
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: mpittet@mgh.harvard.edu.
authors.forename: Mikael J
authors.initials: MJ
authors.lastname: Pittet
mesh_terms: D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D064307:Microbiota; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*; D051198:Toll-Like Receptor 5 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D015850:Interleukin-6; D051198:Toll-Like Receptor 5