title: Salvianolic acid Y: a new protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis.
abstract: Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (1H-1H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H2O2 was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. gongjun_1986@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. juach@tasly.com.
authors.forename: Aichun
authors.initials: A
authors.lastname: Ju
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. zhoudz@tasly.com.
authors.forename: Dazheng
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. lidekun@tasly.com.
authors.forename: Dekun
authors.initials: D
authors.lastname: Li
authors.affiliation: Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. wzhou@tasly.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Tasly R&D Institute, Tasly Pharmaceutical Co., Ltd., Tianjin 300410, China. 1122gengwanli@163.com.
authors.forename: Wanli
authors.initials: W
authors.lastname: Geng
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. libing3@tasly.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. lili4@tasly.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. liuyanjie@tasly.com.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. heying@tasly.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. songmeizhen2013@tasly.com.
authors.forename: Meizhen
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. wangyunhua@tasly.com.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Technology Development, TianJin Tasly Pride Pharmaceutical Co., Ltd., Tianjin 300410, China. yezl@tasly.com.
authors.forename: Zhengliang
authors.initials: Z
authors.lastname: Ye
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100050, China. linrc68@163.com.
authors.forename: Ruichao
authors.initials: R
authors.lastname: Lin
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000633:toxicity*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D016716:PC12 Cells; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D051381:Rats; D027543:Salvia officinalis / Q000737:chemistry*; D053630:Depsides
chemical_list: D000475:Alkenes; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D006861:Hydrogen Peroxide; D018696:Neuroprotective Agents; D059808:Polyphenols; C568740:salvianolic acid; C000601099:salvianolic acid Y; C076944:salvianolic acid B; D053630:Depsides