title: [Synthesis and antifatigue activities of new benzamide derivatives].
abstract: To explore novel antifatigue agents targeting with AMPA receptor, 10 compounds were synthesized and their structures were confirmed by 1H NMR, ESI-MS and elemental analysis. 1-BCP was treated as the leading compound. The antifatigue activities were evaluated by weight-loaded forced swimming test, and the AMPA receptor binding affinities were tested with radioligand receptor binding assays. The results unveiled that 5b appeared to possess potent antifatigue activities and high affinity with AMPA receptor, which deserved further studies.
authors.affiliation: Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang, China.
authors.forename: Wu-Tu
authors.initials: WT
authors.lastname: Fan
authors.forename: Xiang-Long
authors.initials: XL
authors.lastname: Wu
authors.forename: Ya-Lei
authors.initials: YL
authors.lastname: Pan
authors.forename: Yin-Bo
authors.initials: YB
authors.lastname: Niu
authors.forename: Chen-Rui
authors.initials: CR
authors.lastname: Li
authors.forename: Qi-Bing
authors.initials: QB
authors.lastname: Mei
mesh_terms: D000818:Animals; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D004149:Dioxoles / Q000737:chemistry / Q000494:pharmacology; D005221:Fatigue / Q000517:prevention & control*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D018091:Receptors, AMPA / Q000378:metabolism; D013550:Swimming
chemical_list: D001549:Benzamides; D004149:Dioxoles; D010880:Piperidines; D018091:Receptors, AMPA; C085415:1-(1,3-benzodioxol-5-ylcarbonyl)piperidine; C037689:benzamide