title: Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation.
abstract: BACKGROUND
  Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, we showed that the common marker for cardiac damage, troponin T, was not elevated by chemoradiation [Lung Cancer 62:351-355, 2008]. In this study, we explore whether dose-volume metrics and biomarkers for cardiac damage, inflammation or angiogenesis could identify patients receiving thoracic radiation who would later have cardiac or pulmonary complications.
  
  
  RESULTS
  To this end, we quantified cardiac biomarkers including c-reactive protein (cRP) as well as a panel of angiogenic and inflammatory molecules in thirty patients who received radiation therapy to the thorax with or without concurrent chemotherapy between May 2006 and May 2007. Serum was collected at baseline, 2 weeks into radiation treatment and at the completion of radiation therapy. Heart and lung dosimetric parameters and clinical risk factors were also examined, along with the monitoring of adverse pulmonary and cardiac events during follow-up. Contrary to our hypothesis, there was no correlation between serum biomarker levels and cardiac radiation dose. Similarly there was little association between lung dose-volume metrics and inflammatory or angiogenic biomarkers. Furthermore, there was no correlation with serum biomarkers and adverse pulmonary or cardiovascular events.
  
  
  CONCLUSIONS
  Based on these data, acute elevations in serum biomarkers of cardiac damage, inflammation or angiogenesis should not be attributed to thoracic (chemo)radiation and elevations in such biomarkers of tissue damage should be further evaluated.
authors.affiliation: Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox-737, 100 Blossom Street, Boston, MA, 02114, USA. angekuo@gmail.com.|Current Affiliation: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. angekuo@gmail.com.
authors.forename: Angera H
authors.initials: AH
authors.lastname: Kuo
authors.affiliation: Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox-737, 100 Blossom Street, Boston, MA, 02114, USA. ma0089@gmail.com.
authors.forename: Marek
authors.initials: M
authors.lastname: Ancukiewicz
authors.affiliation: Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox-737, 100 Blossom Street, Boston, MA, 02114, USA. kevin_kozak@yahoo.com.|Current Affiliation: Mercy Regional Cancer Center, Janesville, WI, USA. kevin_kozak@yahoo.com.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Kozak
authors.affiliation: Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox-737, 100 Blossom Street, Boston, MA, 02114, USA. tyock@partners.org.
authors.forename: Torunn I
authors.initials: TI
authors.lastname: Yock
authors.affiliation: Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox-737, 100 Blossom Street, Boston, MA, 02114, USA. tpadera@steele.mgh.harvard.edu.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Padera
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D059248:Chemoradiotherapy; D005260:Female; D006338:Heart Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators