title: Neutral N^C^N terdentate luminescent Pt(II) complexes: their synthesis, photophysical properties, and bio-imaging applications.
abstract: An emerging field regarding N^C^N terdentate Pt(II) complexes is their application as luminescent labels for bio-imaging. In fact, phosphorescent Pt complexes possess many advantages such as a wide emission color tunability, a better stability towards photo- and chemical degradation, a very large Stokes shift, and long-lived luminescent excited states with lifetimes typically two to three orders of magnitude longer than those of classic organic fluorophores. Here, we describe the synthesis and photophysical characterization of three new neutral N^C^N terdentate cyclometallated Pt complexes as long-lived bio-imaging probes. The novel molecular probes bear hydrophilic (oligo-)ethyleneglycol chains of various lengths to increase their water solubility and bio-compatibility and to impart amphiphilic nature to the molecules. The complexes are characterized by a high cell permeability and a low cytotoxicity, with an internalization kinetics that depends on both the length of the ethyleneglycol chain and the ancillary ligand.
authors.affiliation: Dipartimento di Chimica dell'Università degli Studi di Milano, UdR-INSTM, via Golgi 19, I-20133 Milano, Italy. claudia.dragonetti@unimi.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Colombo
authors.forename: Federica
authors.initials: F
authors.lastname: Fiorini
authors.forename: Dedy
authors.initials: D
authors.lastname: Septiadi
authors.forename: Claudia
authors.initials: C
authors.lastname: Dragonetti
authors.forename: Filippo
authors.initials: F
authors.lastname: Nisic
authors.forename: Adriana
authors.initials: A
authors.lastname: Valore
authors.forename: Dominique
authors.initials: D
authors.lastname: Roberto
authors.forename: Matteo
authors.initials: M
authors.lastname: Mauro
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D049408:Luminescent Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018613:Microscopy, Confocal; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D049408:Luminescent Agents; D009944:Organoplatinum Compounds