title: Testosterone differs between suicide attempters and community controls in men and women of China.
abstract: OBJECTIVE
  To understand how physiological markers of men and women characterize the differences in suicide attempt, we hypothesize that attempted suicides have higher level of testosterone than their non-suicidal counterparts, which should be true of both men and women.
  
  
  METHODS
  In Shandong Province of China, 245 rural suicide attempters aged 16-50years were consecutively recruited from October 1, 2009 to March 31, 2011. They were compared with 245 age and gender matched community controls. Blood sample was extracted at the time of interview for both patients and controls, and the plasma testosterone level was tested for comparisons.
  
  
  RESULTS
  The testosterone level was significantly higher for male suicide attempters than for their community counterparts, with the OR of 1.211 (95%CI: 1.055-1.391), even when some other factors were adjusted, such as education years, family SES, marital status, coping skills, impulsivity, and psychiatric disorders. There was also a tendency that high testosterone level was related to female suicide attempt, with the OR being 1.209 (95%CI: 0.719-2.031).
  
  
  CONCLUSIONS
  Testosterone, as a form of physiological marking, is somewhat another predictor of attempted suicide. Besides other factors, it might be the testosterone, not gender, which explains the suicide risks and the gender ratio of the rates. The lack of sample size limited this current study to establish a significant and positive relationship between testosterone and suicide risk in women as found in men.
authors.affiliation: Shandong University School of Public Health, Center for Suicide Prevention Research, Jinan 250012, China; State University of New York Buffalo State, Buffalo, NY 14222, USA. Electronic address: zhangj@buffalostate.edu.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shandong University School of Public Health, Center for Suicide Prevention Research, Jinan 250012, China.
authors.forename: Cun-Xian
authors.initials: CX
authors.lastname: Jia
authors.affiliation: Center for Disease Prevention and Control of Shizhong District of Jinan, Jinan 250022, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D013406:Suicide, Attempted; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone
keywords: China; Gender; Suicide; Suicide attempt; Testosterone