title: Enantioselective total synthesis of (-)-nardoaristolone B via a gold(I)-catalyzed oxidative cyclization.
abstract: The first enantioselective total synthesis of (-)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Homs
authors.forename: Michael E
authors.initials: ME
authors.lastname: Muratore
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Echavarren
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D003300:Copper; D003500:Cyclization; D006046:Gold; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D012717:Sesquiterpenes; C581893:nardoaristolone B; D006046:Gold; D003300:Copper