title: The effects of long chain polyunsaturated fatty acids on local activation properties in dogs vulnerable to atrial fibrillation.
abstract: Marine derived long chain polyunsaturated fatty acids (PUFAs) were found to have benefits in reducing inducibility and maintenance of atrial fibrillation (AF) in a dog model. This study was conducted to evaluate the effect of PUFAs on local atrial electrical conduction properties acquired via a multi-electrode plaque sutured to the posterior wall of the left atrium of the heart in these dogs. Eleven dogs underwent simultaneous atrioventricular pacing (SAVP) for 2 weeks, and were organized into 2 groups: 5 dogs received no PUFAs (SAVP-PLACEBO), 6 dogs received Eicosapentaenoic or Docosahexaenoic acid derived from fish oils (SAVP-PUFA), where PUFAs were given for 21 days, starting 1 week prior to pacing and during the 2 week pacing period. Three features were extracted, which were the average conduction velocity, average intra atrial conduction time, and total activation time. The PUFA group had a faster average conduction velocity (0.82±0.19 m/s) than the PLACEBO group (0.47±0.21 m/s, P=0.02). Using the average conduction velocity feature, classification was performed with a linear classifier and leave-one-out method. In the SAVP-PLACEBO group, 60% of the dogs were correctly classified, and 66% of the dogs were correctly classified in SAVP-PUFA group, leading to an overall classification accuracy of 63.5%.
authors.forename: R
authors.initials: R
authors.lastname: Abdulmajeed
authors.forename: A
authors.initials: A
authors.lastname: Ramadeen
authors.forename: S
authors.initials: S
authors.lastname: Masse
authors.forename: F H
authors.initials: FH
authors.lastname: Foomany
authors.forename: K
authors.initials: K
authors.lastname: Balasundaram
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: K
authors.initials: K
authors.lastname: Nanthakumar
authors.forename: P
authors.initials: P
authors.lastname: Dorian
authors.forename: K
authors.initials: K
authors.lastname: Umapathy
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage*; D006325:Heart Atria / Q000503:physiopathology; D009200:Myocardial Contraction
chemical_list: D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid