title: Clonal evolution in cancer: a tale of twisted twines.
abstract: Intra-tumor heterogeneity of cancer cells hampers the design of effective therapies and yet it is poorly reproduced in experimental models. A recent report by Eirew at al. provides an in-depth analysis of genetic heterogeneity of breast tumor xenografts and shows that changes in clonal diversity might not be stochastic.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Michalina
authors.initials: M
authors.lastname: Janiszewska
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: kornelia_polyak@dfci.harvard.edu.
authors.forename: Kornelia
authors.initials: K
authors.lastname: Polyak
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D002999:Clone Cells / Q000378:metabolism* / Q000473:pathology*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D059010:Single-Cell Analysis; D023041:Xenograft Model Antitumor Assays