title: Suboptimal use of gastroprotective medication in elderly antiplatelet users.
abstract: BACKGROUND
  Use of acetylsalicylic acid (ASA) or thienopyridines in monotherapy or combination of both drugs is associated with increased risk of gastrointestinal (GI) bleeding. The administration of drugs inhibiting gastric acid production represents an effective way to avoid GI disorders associated with antiplatelet therapy.
  
  
  OBJECTIVE
  The aim of our study was to evaluate the use of gastroprotective medication in elderly antiplatelet users in relation to risk factors for GI bleeding.
  
  
  METHODS
  Patients (n = 428) aged ≥ 65 years who were prescribed low dose ASA or clopidogrel in monotherapy or combination at hospital discharge were enrolled in the study.
  
  
  RESULTS
  Only 39.7 % of patients with 2 or more risk factors for GI bleeding were prescribed gastroprotective medication at hospital discharge. The probability of elderly antiplatelet drug user for prescription of gastroprotective medication was improved with following risk factors: age ≥ 85 years (OR = 2.99); history of peptic ulcer disease/ GI bleeding (OR = 15.79); other GI disorders (OR = 15.48); concomitant therapy with drugs increasing the risk of GI bleeding - systemic corticosteroids (OR = 29.03) and NSAIDs (OR = 4.79).
  
  
  CONCLUSIONS
  Results of our study indicate the necessity to increase the awareness of GI bleeding risk in long-term antiplatelet users among prescribing physicians.
authors.forename: V
authors.initials: V
authors.lastname: Slezakova
authors.forename: Z
authors.initials: Z
authors.lastname: Varga
authors.forename: J
authors.initials: J
authors.lastname: Murin
authors.forename: J
authors.initials: J
authors.lastname: Schweigertova
authors.forename: S
authors.initials: S
authors.lastname: Jankyova
authors.forename: T
authors.initials: T
authors.lastname: Foltanova
authors.forename: M
authors.initials: M
authors.lastname: Zabka
authors.forename: M
authors.initials: M
authors.lastname: Bozik
authors.forename: M
authors.initials: M
authors.lastname: Wawruch
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D020011:Protective Agents / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D010975:Platelet Aggregation Inhibitors; D020011:Protective Agents