title: mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
abstract: Oncogene-induced senescence (OIS) is thought to be a barrier to malignant transformation resulting from the strong activation of oncogenes. In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
authors.affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: George P
authors.initials: GP
authors.lastname: Souroullas
authors.affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: nes@med.unc.edu.
authors.forename: Norman E
authors.initials: NE
authors.lastname: Sharpless
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D008546:Melanoma, Experimental / Q000473:pathology*; D046912:Multiprotein Complexes / Q000378:metabolism*; D009506:Nevus / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; C482120:Braf protein, mouse; D000076222:Mechanistic Target of Rapamycin Complex 1; D017346:Protein Serine-Threonine Kinases; D048493:Proto-Oncogene Proteins B-raf; C491654:Stk11 protein, mouse; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases