title: A computational model for bipolar deep brain stimulation of the subthalamic nucleus.
abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to reduce some of the symptoms of advanced, levodopa-responsive Parkinson's disease that are not adequately controlled with medication. However, the precise mechanism of the therapeutic action of DBS is still unclear. Stimulation-induced side effects are not uncommon and require electrical "dose" adjustments. Quantitative methods are needed to fully characterize the electric field in the deep brain region that surrounds the electrodes in order to help with adjustments and maximize the efficacy of the device. Herein we report a magnetic resonance imaging (MRI)-based head model proposed for analysis of fields generated by deep brain stimulation (DBS). The model was derived from multimodal image data at 0.5mm isotropic spatial resolution and distinguishes 142 anatomical structures, including the basal ganglia and 38 nuclei of the thalamus. Six bipolar electrode configurations (1-2, 1-3, 1-4, 2-3, 2-4, 3-4) were modeled in order to assess the effects of the inter-electrode distance of the electric field. Increasing the distance between the electrodes results in an attenuated stimulation, with up to 25% reduction in electric field amplitude delivered (2-3 vs. 1-4). The map of the deep brain structures provided a highly precise anatomical detail which is useful for the quantitative assessment of current spread around the electrode and a better evaluation of the stimulation setting for the treatment optimization.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Iacono
authors.forename: Esra
authors.initials: E
authors.lastname: Neufeld
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bonmassar
authors.forename: Esther
authors.initials: E
authors.lastname: Akinnagbe
authors.forename: Andras
authors.initials: A
authors.lastname: Jakab
authors.forename: Ethan
authors.initials: E
authors.lastname: Cohen
authors.forename: Niels
authors.initials: N
authors.lastname: Kuster
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kainz
authors.forename: Leonardo M
authors.initials: LM
authors.lastname: Angelone
mesh_terms: D000328:Adult; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000379:methods*; D004560:Electricity; D004566:Electrodes; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008953:Models, Anatomic; D008959:Models, Neurological; D020531:Subthalamic Nucleus / Q000503:physiopathology*