title: Prostatic stromal sarcoma in an adolescent: the role of chemotherapy.
abstract: Prostatic stromal sarcoma (PSS) is a rare tumor that normally occurs in adult age. Its management relies mainly on surgery. We report the first case of PSS occurring in an adolescent. There was evidence of a good response to chemotherapy including ifosfamide, doxorubicin, vincristine and actinomycin-D, although the final outcome was dismal. A review of the English literature revealed 14 additional patients with PSS treated with chemotherapy: tumor shrinkage was reported in 4 of the 6 evaluable patients. Patients with PSS may benefit from the use of chemotherapy in combination with early aggressive local treatment.
authors.affiliation: Pediatric Hematology and Oncology Division Department of Woman's and Child's Health, Padova University Hospital , Padova, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cavaliere
authors.affiliation: Pathology Department, Padova University Hospital , Padova, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Alaggio
authors.affiliation: Urology Department, Padova University Hospital , Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Castagnetti
authors.affiliation: Radiotherapy Department, Istituto Oncologico Veneto-IRCCS , Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scarzello
authors.affiliation: Pediatric Hematology and Oncology Division Department of Woman's and Child's Health, Padova University Hospital , Padova, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Bisogno
keywords: chemotherapy; prostatic neoplasm; specialized prostatic stroma; stromal sarcoma