title: Neoadjuvant hormone therapy following treatment with robotic-assisted radical prostatectomy achieved favorable in high-risk prostate cancer.
abstract: OBJECTIVE
  Patients with a high risk of prostate carcinoma typically have higher rates of positive surgical margins and biochemical failure following radical prostatectomy and adjuvant hormone therapy. In this study, we assessed the effects of neoadjuvant hormone therapy (NHT) on prostate carcinoma in high-risk patients following robotic-assisted radical prostatectomy (RARP).
  
  
  METHODS
  This retrospective study investigated the medical records of 28 patients who underwent RARP between January 2009 and October 2013. Twenty-two patients underwent NHT prior to RARP. Furthermore, six patients did not undergo NHT prior to RARP. Parameters including age, operating time, blood loss, blood transfusion status, and cancer stage were checked against anatomical correlations. Potential predictors of prolonged operating time and prolonged surgical procedures were assessed using multiple logistic regressions.
  
  
  RESULTS
  NHT was shown to be an independent predictor of prolonged total operating time. Tumor stage alterations did not appear to be associated with NHT followed by RARP. The patients who underwent NHT were not more likely to have positive surgical margins, and an increase in patients requiring blood transfusion was not seen.
  
  
  CONCLUSIONS
  NHT appears to increase operative time during RARP. However, the perioperative morbidity of NHT patients undergoing RARP appears to be equivalent with that of non-NHT patients.
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Cheng-Pang
authors.initials: CP
authors.lastname: Hou
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Wei-Chang
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Yu-Hsiang
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Hou-Pin Taipei Hospital, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Shao-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Chien-Lun
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; Bioinformation Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Phei-Lang
authors.initials: PL
authors.lastname: Chang
authors.affiliation: Bioinformation Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; Department of Anatomy, School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Horng-Heng
authors.initials: HH
authors.lastname: Juang
authors.affiliation: Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; School of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China ; Bioinformation Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
authors.forename: Ke-Hung
authors.initials: KH
authors.lastname: Tsui
keywords: operating time; prostate carcinoma; robotic-assisted radical prostatectomy; surgical margin