title: Simple chained guide trees give poorer multiple sequence alignments than inferred trees in simulation and phylogenetic benchmarks.
authors.affiliation: Faculty of Medicine, Department of Molecular Sciences, Institute of Clinical Sciences, Imperial College London, London W12 0NN, United Kingdom; Computational Regulatory Genomics, Medical Research Council Clinical Sciences Centre, London W12 0NN, United Kingdom;
authors.forename: Ge
authors.initials: G
authors.lastname: Tan
authors.affiliation: Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland; Swiss Institute of Bioinformatics, 8092 Zurich, Switzerland;
authors.forename: Manuel
authors.initials: M
authors.lastname: Gil
authors.affiliation: Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland;
authors.forename: Ari P
authors.initials: AP
authors.lastname: Löytynoja
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom; and.
authors.forename: Nick
authors.initials: N
authors.lastname: Goldman
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom; and Department of Genetics, Evolution & Environment and Department of Computer Science, University College London, London WC1E 6BT, United Kingdom c.dessimoz@ucl.ac.uk.
authors.forename: Christophe
authors.identifier: http://orcid.org/0000-0002-2170-853X
authors.initials: C
authors.lastname: Dessimoz
mesh_terms: D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D011506:Proteins