title: REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.
abstract: Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several pro-oncogenic Spregulated genes important for cancer cell proliferation, survival and metastasis. The mechanism of these responses involve ROS-dependent downregulation of microRNA-27a (miR-27a) or miR-20a (and paralogs) and induction of two Sp-repressors, ZBTB10 and ZBTB4 respectively. This pathway significantly contributes to the anticancer activity of ROS inducers and should be considered in development of drug combinations for cancer chemotherapy.
authors.affiliation: VMR 1197, Room 413, Texas A&M University, College Station, TX, 77843 979-845-9182 ssreevalsan@cvm.tamu.edu.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sreevalsan
authors.affiliation: VMR 1197, Room 410, Texas A&M University, College Station, TX, 77843 979-845-5988.
authors.forename: Stephen
authors.initials: S
authors.lastname: Safe
keywords: Colon cancer; antioxidants; mechanism based drugs; microRNA; reactive oxygen Species; specificity transcription factors; targeted therapy; zinc finger DNA binding proteins