title: Boronate based metal-free platform for diphosphate-specific molecular recognitions.
abstract: A reversible boronate-diol interaction provides a versatile synthetic platform for molecular recognitions whose binding specificity can be molecularly tailored. We found that boronate derivatives with relatively strong acidity generally undergo a diphosphate-specific recognition among other phosphates under weakly acidic pH conditions, a feature relevant to DNA sequencing. (11)B and (31)P NMR studies identified "tetrahedral boronate and divalent diphosphate" as a pair responsible for forming a 1:1 stoichiometric complex, which manifests as a unique pH-dependent stability.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University , Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Sanjoh
authors.forename: Daisuke
authors.initials: D
authors.lastname: Iizuka
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyahara
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D011756:Diphosphates / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D001897:Boronic Acids; D011756:Diphosphates; D004247:DNA