title: [Pathologic analysis of primary cardiac inflammatory myofibroblastic tumor].
abstract: OBJECTIVE
  To study the clinical and pathologic features of primary cardiac inflammatory myofibroblastic tumor.
  
  
  METHODS
  A total of 4 patients with primary cardiac inflammatory myofibroblastic tumor were encountered during the period from 1993 to 2013 in National Center for Cardiovascular Disease. The clinical features, imaging findings and outcomes of the 4 patients were evaluated. ALK protein expression and ALK gene status were studied using the archival tumor tissues.
  
  
  RESULTS
  There were 1 female and 3 male patients. The age of patients ranged from 5 months to 30 years (mean = 16 years). The tumor was located in right ventricle (n = 2), right atrium (n = 1) or pericardium (n = 1). Histologic patterns included 2 cases of fibrous histiocytoma type, 1 case of granulomatous type and 1 case of sclerosing type. Immunohistochemical study showed that 2 cases expressed ALK protein. Fluorescence in-situ hybridization however did not reveal any ALK gene rearrangement.
  
  
  CONCLUSIONS
  Inflammatory myofibroblastic tumor of the heart is rarely encountered and easily misdiagnosed. It carries distinctive clinical and pathologic features. ALK protein expression is helpful in arriving at the correct diagnosis.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Department of Pathology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xuejing
authors.initials: X
authors.lastname: Duan
authors.forename: Hongyue
authors.initials: H
authors.lastname: Wang
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Wang
authors.forename: Dingrong
authors.initials: D
authors.lastname: Zhong
authors.affiliation: E-mail: zhaohongfw@aliyun.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006104:Granuloma, Plasma Cell / Q000201:enzymology / Q000473:pathology*; D006338:Heart Neoplasms / Q000201:enzymology / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases