title: Detection and quantification of residues and metabolites of medicinal products in environmental compartments, food commodities and workplaces. A review.
abstract: The toxicological assessment of medicinal products (MPs) and their residues and metabolites in the environment have become a challenging task worldwide. The contamination of environmental compartments, biota, workplace, foodstuff and feedstuff by residues and metabolites of these substances poses a risk to human health which is still far from being fully understood. On the other hand, existing analytical methods not always possess sufficient detection power to quantify residues of MPs at very low concentrations. This review sets forth some of the most significant contributions made in this field over the past decade with a special focus on novel fit-for-purpose analytical approaches for the detection, identification and quantification of these pollutants and the assessment of their noxious potential for human beings and the environment.
authors.affiliation: Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: Paola.Bottoni@iss.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Bottoni
authors.affiliation: Società di Scienze Farmacologiche Applicate (Society of Applied Pharmacological Science), Viale Abruzzi 32, 20131 Milan, Italy. Electronic address: Sergio.Caroli@libero.it.
authors.forename: Sergio
authors.initials: S
authors.lastname: Caroli
mesh_terms: D000818:Animals; D004350:Drug Residues / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D017132:Workplace
keywords: Analytical methods; Environmental media; Food; Pharmaceuticals; Workplace