title: Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
abstract: OBJECTIVE
  We evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
  
  
  METHODS
  Patients assigned to STICH Hypothesis 1 were randomized to medical therapy with or without coronary artery bypass grafting (CABG). Those assigned to STICH Hypothesis 2 were randomized to CABG or CABG with left ventricular reconstruction.
  
  
  RESULTS
  In patients assigned to STICH Hypothesis 2 (n = 714), no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance (p < 0.002); however, several variants met nominal prognostic significance: variants in the β2-adrenergic receptor gene (β2-AR Gln27Glu) and in the A1-adenosine receptor gene (A1-717 T/G) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem (p = 0.027 and 0.031, respectively). These relationships remained nominally significant even after multivariable adjustment for prognostic clinical variables. However, none of the 23 genetic variants influenced all-cause mortality or the combination of death or cardiovascular hospitalization in the STICH Hypothesis 1 population (n = 532) by either univariate or multivariable analysis.
  
  
  CONCLUSIONS
  We were unable to identify the predictive genotypes in optimally treated patients in these two ischemic heart failure populations.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pa., USA.
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Feldman
authors.forename: Lilin
authors.initials: L
authors.lastname: She
authors.forename: Dennis M
authors.initials: DM
authors.lastname: McNamara
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bristow
authors.forename: Alan S
authors.initials: AS
authors.lastname: Maisel
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wagner
authors.forename: Bert
authors.initials: B
authors.lastname: Andersson
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiariello
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hayward
authors.forename: Paul
authors.initials: P
authors.lastname: Hendry
authors.forename: John D
authors.initials: JD
authors.lastname: Parker
authors.forename: Normand
authors.initials: N
authors.lastname: Racine
authors.forename: Craig H
authors.initials: CH
authors.lastname: Selzman
authors.forename: Michele
authors.initials: M
authors.lastname: Senni
authors.forename: Janina
authors.initials: J
authors.lastname: Stepinska
authors.forename: Marian
authors.initials: M
authors.lastname: Zembala
authors.forename: Jean
authors.initials: J
authors.lastname: Rouleau
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Lee
mesh_terms: D000368:Aged; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000379:methods; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006333:Heart Failure / Q000235:genetics* / Q000401:mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D043682:Receptor, Adenosine A1 / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012307:Risk Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D043682:Receptor, Adenosine A1; D018343:Receptors, Adrenergic, beta-2