title: HIV transmission and related risk factors among serodiscordant couples in Liuzhou, China.
abstract: To evaluate the incidence and risk factors for human immunodeficiency virus (HIV) seroconversion of HIV-negative partners among HIV-discordant couples in Liuzhou, China, 1854 eligible HIV-serodiscordant couples were retrospectively identified through the HIV epidemiology and follow-up database from January 1, 1996 to June 30, 2013. Cox proportional-hazards model was used to examine risk factors related to HIV seroconversion of negative partners. Finally, 125 HIV seroconversion occurred over 4963.5 person-years, resulting in an overall HIV incidence of 2.52/100 person-years. HIV-positive partners with the last CD4 counts of 350 cells/ul or more were significantly protected against HIV seroconversion compared with those CD4 counts of less than 200 cells/ul (aHR = 0.46, 95% CI: 0.27-0.81, P < 0.01). Men with HIV-positive wives (aHR: 1.96, 95% CI: 1.27-3.02, P < 0.01), HIV-positive partners who did not receive ART before their HIV-negative partners' seroconversion (aHR: 2.22, 95% CI, 1.41-3.51, P < 0.01) and patients reported intermittent condom use (aHR: 7.60, 95% CI, 4.37-13.21, P < 0.01) were associated with increased risk of HIV seroconversion. HIV-negative partners remain high risk of HIV infection in Liuzhou city. Comprehensive package of HIV prevention services should contribute to reduction in HIV transmission of discordant couples.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Xian-Xiang
authors.initials: XX
authors.lastname: Feng
authors.forename: Yin-Guang
authors.initials: YG
authors.lastname: Fan
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Xiang-Hai
authors.initials: XH
authors.lastname: Zhong
authors.forename: Ming-Qiang
authors.initials: MQ
authors.lastname: Li
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D018562:Disease Transmission, Infectious; D005191:Family Characteristics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D006679:HIV Seropositivity; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D047568:Unsafe Sex; D055815:Young Adult
keywords: antiretroviral therapy; condom use; human immunodeficiency virus; incidence; retrospective study