title: Anthelmintic drug discovery: into the future.
abstract: The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.
authors.affiliation: Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Geary
authors.forename: Judy A
authors.initials: JA
authors.lastname: Sakanari
authors.forename: Conor R
authors.initials: CR
authors.lastname: Caffrey
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends; D004359:Drug Therapy, Combination; D006373:Helminthiasis / Q000188:drug therapy*; D006374:Helminthiasis, Animal / Q000188:drug therapy; D006376:Helminths / Q000145:classification / Q000187:drug effects*; D006801:Humans; D010641:Phenotype
chemical_list: D000871:Anthelmintics