title: Antisense Modulation of RNA Processing as a Therapeutic Approach in Cancer Therapy.
abstract: Next-generation antisense technologies are re-emerging as viable and powerful approaches to the treatment of several genetic diseases. Similar strategies are also being applied to cancer therapy. Re-programming of the expression of endogenous oncogenic products to replace them with functional antagonists, by interfering with alternative splicing or polyadenylation, provides a promising novel approach to address acquired drug resistance and previously undruggable targets.
authors.affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Spraggon
authors.affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: Luca
authors.initials: L
authors.lastname: Cartegni