title: The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c.
abstract: In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c-Pt(NH3)2 and cyt c-Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously.
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126, Napoli, Italy. antonello.merlino@unina.it.
authors.forename: Giarita
authors.initials: G
authors.lastname: Ferraro
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
authors.forename: Antonello
authors.initials: A
authors.lastname: Merlino
mesh_terms: D002945:Cisplatin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D045304:Cytochromes c / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D045304:Cytochromes c; D002945:Cisplatin