title: The potential perinatal origin of placentation disorders in the young primigravida.
abstract: The fetus is exposed to high plasma concentrations of unbound estrogens and progesterone throughout pregnancy. However, secretory or decidual changes in the fetal uterus occur relatively infrequently before birth, suggesting a variable endometrial progesterone response at the time of birth. Arguably, partial progesterone resistance that persists into adolescent years may compromise the physiological transformation of the spiral arteries and predispose for defective placentation in the case of pregnancy. Decidualization of the endometrial stromal compartment and junctional zone myometrium precedes trophoblast invasion. It represents the first step in the process of spiral artery remodeling needed to establish effective uteroplacental blood flow by midpregnancy. The major obstetric syndromes caused by impaired placental bed spiral artery remodeling are prevalent in teenage pregnancies, including preeclampsia, fetal growth restriction, and spontaneous preterm labor. Preconditioning of the uterus in response to cyclic menstruation during adolescence may be critical to achieve full uterine responsiveness to hormonal cues. Understanding the mechanisms of functional maturation of the uterus during the early reproductive years may yield novel insights into the major obstetric syndromes.
authors.affiliation: Catholic University Leuven and Leuven Institute for Fertility and Embryology, Leuven, Belgium. Electronic address: ivo.brosens@med.kuleuven.be.
authors.forename: Ivo
authors.initials: I
authors.lastname: Brosens
authors.affiliation: Department of Gynecology, Obstetrics, and Urology, Sapienza University, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Benagiano
authors.affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom.
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Brosens
mesh_terms: D000293:Adolescent; D002584:Cervix Uteri / Q000196:embryology; D004717:Endometrium / Q000002:abnormalities* / Q000196:embryology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D020073:Gravidity; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000209:etiology; D010922:Placenta Diseases / Q000209:etiology*; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011253:Pregnancy in Adolescence; D014591:Uterine Diseases / Q000150:complications / Q000196:embryology*; D014599:Uterus / Q000196:embryology*
keywords: decidua; obstetric syndromes; placentation; preconditioning; progesterone resistance