title: PD-1/PD-L1 pathway in non-small-cell lung cancer and its relation with EGFR mutation.
abstract: Immunotherapy has become a crucial modality for non-small-cell lung cancer treatment. Recently, two immune checkpoints, PD-1 and PD-L1, have emerged as important targets for immunotherapy. Their antitumor efficacy has been confirmed by in vitro and in vivo studies. But the correlation between PD-1/PD-L1 expression and EGFR expression was controversial and needs more evidences to support the combination of PD-1/PD-L1 inhibitors and tyrosine kinase inhibitors.
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China. jimei90@sina.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.affiliation: Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, China. 15051973544@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, China. liqing@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China. shuiliuhefang@163.com.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China. zhaowq11@163.com.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, USA. kevin511511@gmail.com.
authors.forename: Hanze
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 274365378@qq.com.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China. wcpjjt@163.com.
authors.forename: Jing-Ting
authors.initials: JT
authors.lastname: Jiang
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China. wcpjscz@163.com.
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Wu
mesh_terms: D000818:Animals; D060890:B7-H1 Antigen / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics*; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*
chemical_list: D060890:B7-H1 Antigen; D061026:Programmed Cell Death 1 Receptor; D066246:ErbB Receptors