title: Inner ocular blood flow responses to an acute decrease in blood pressure in resting humans.
abstract: Whether inner ocular vessels have an autoregulatory response to acute fluctuations in blood pressure is unclear. We tried to examine the validity of acute hypotension elicited by thigh-cuff release as to assess the dynamic autoregulation in the ocular circulation. Blood flow velocity in the superior nasal and inferior temporal retinal arterioles, and in the retinal and choroidal vasculature were measured with the aid of laser speckle flowgraphy before and immediately after an acute decrease in blood pressure in 20 healthy subjects. Acute hypotension was induced by a rapid release of bilateral thigh occlusion cuffs that had been inflated to 220 mmHg for 2 min. The ratio of the relative change in retinal and choroidal blood flow velocity to the relative change in mean arterial blood pressure (MAP) was calculated. Immediately after cuff release, the MAP and blood flows in the all ocular target vessels decreased significantly from the baseline values obtained before thigh-cuff release. The ratio of the relative change in inner ocular blood flow velocity to that in the MAP exceeded 1% / %mmHg. An explicit dynamic autoregulation in inner ocular vessels cannot be demonstrated in response to an acute hypotension induced by the thigh-cuff release technique.
authors.affiliation: Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, 359-1192, Japan. Graduate School of Decision Science and Technology, Tokyo Institute of Technology, Ookayama, Meguro, 152-8552, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ikemura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kashima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Akane
authors.initials: A
authors.lastname: Miyaji
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005123:Eye / Q000098:blood supply*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology