title: An investigation into the association between DNA damage and dietary fatty acid in men with prostate cancer.
abstract: Prostate cancer is a growing problem in New Zealand and worldwide, as populations adopt a Western style dietary pattern. In particular, dietary fat is believed to be associated with oxidative stress, which in turn may be associated with cancer risk and development. In addition, DNA damage is associated with the risk of various cancers, and is regarded as an ideal biomarker for the assessment of the influence of foods on cancer. In the study presented here, 20 men with prostate cancer adhered to a modified Mediterranean style diet for three months. Dietary records, blood fatty acid levels, prostate specific antigen, C-reactive protein and DNA damage were assessed pre- and post-intervention. DNA damage was inversely correlated with dietary adherence (p = 0.013) and whole blood monounsaturated fatty acids (p = 0.009) and oleic acid (p = 0.020). DNA damage was positively correlated with the intake of dairy products (p = 0.043), red meat (p = 0.007) and whole blood omega-6 polyunsaturated fatty acids (p = 0.015). Both the source and type of dietary fat changed significantly over the course of the dietary intervention. Levels of DNA damage were correlated with various dietary fat sources and types of dietary fat.
authors.affiliation: Auckland Cancer Society Research Centre, FM & HS, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. k.bishop@auckland.ac.nz.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Bishop
authors.affiliation: Discipline of Nutrition, FM & HS, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. sharon.erdrich@gmail.com.
authors.forename: Sharon
authors.initials: S
authors.lastname: Erdrich
authors.affiliation: Auckland Cancer Society Research Centre, FM & HS, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. n.karunasinghe@auckland.ac.nz.
authors.forename: Nishi
authors.initials: N
authors.lastname: Karunasinghe
authors.affiliation: Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. dy.han@auckland.ac.nz.
authors.forename: Dug Yeo
authors.initials: DY
authors.lastname: Han
authors.affiliation: Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. st.zhu@auckland.ac.nz.
authors.forename: Shuotun
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Nutrigenomics New Zealand, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. amalini3@hotmail.com.
authors.forename: Amalini
authors.initials: A
authors.lastname: Jesuthasan
authors.affiliation: Auckland Cancer Society Research Centre, FM & HS, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. sharon.erdrich@gmail.com.
authors.forename: Lynnette R
authors.initials: LR
authors.lastname: Ferguson
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D004249:DNA Damage; D003611:Dairy Products / Q000032:analysis; D004032:Diet; D015930:Diet Records; D038441:Diet, Mediterranean; D066273:Diet, Western / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage* / Q000097:blood; D005227:Fatty Acids / Q000008:administration & dosage* / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000097:blood; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008460:Meat / Q000032:analysis*; D008875:Middle Aged; D009520:New Zealand; D019301:Oleic Acid / Q000008:administration & dosage / Q000097:blood; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D011471:Prostatic Neoplasms
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D019301:Oleic Acid; D002097:C-Reactive Protein