title: Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis.
abstract: BACKGROUND
  Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increased plasma levels of FDPs in OSMF.
  
  
  OBJECTIVE
  The aim of this study was to quantify the plasma FDPs levels in the individuals with the habit of areca nut chewing with and without OSMF.
  
  
  METHODS
  Total of 95 subjects were included,35 subjects with the habit of areca nut chewing with OSMF, 30 with the habit of areca nut chewing without OSMF, 30 without any habit of areca nut chewing without OSMF (control group). Five ml of venous blood was withdrawn from all the subjects and plasma FDP levels were estimated.
  
  
  RESULTS
  Plasma FDPs were detected in all the subjects of OSMF but could not be detected in other two groups. As the clinical grades of OSMF increased, levels of plasma FDPs also increased.
  
  
  CONCLUSIONS
  When plasma FDP increases, fibrin deposition also increases. This strengthens the finding that these FDPs may be an early indicator of the OSMF.
authors.affiliation: Senior Lecturer, Department of Oral Pathology, Swami Devi Dyal Hospital & Dental College , Golpura, Barwala, India .
authors.forename: Sonia
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Professor, Department of Oral Pathology, MMCDSR , Mullana, Ambala, India .
authors.forename: Manjunath
authors.initials: M
authors.lastname: Sm
authors.affiliation: Professor & HOD, Department of Oral Pathology, Laxmibai institute of Dental Sciences and Hospital , Patiala, India .
authors.forename: Manveen Kaur
authors.initials: MK
authors.lastname: Jawanda
authors.affiliation: Assistant Professor, Department of Oral Pathology, Govt Dental College , Rohtak, India .
authors.forename: Achla
authors.initials: A
authors.lastname: Bharti
keywords: Areca nut; FDPs; Fibrin; Fibrinogen; OSMF