title: Molecular and genetic basis of depression.
abstract: Joyousness or sadness is normal reaction to state of life. If any of these lead to certain semi-permanent changes in daily life, then it is termed as mental disorder. Depression is one of the mental disorders with a state of low mood and aversion to activities that exerts a negative effect on a person's thoughts and behaviour. Adolescent group is probably the world's largest active group of people, who are getting prone to this state of mind leading to their diminished mental and physical abilities. Depression is closely linked to stress and thus a chronic stressful life can increase the risk of depression. Depression is a complex disease having both genetic and environmental components as contributing factors. In this study an attempt has been made to put forward the understanding of the known genes and their functional relationships with depression and stress with special reference to BDNF and 5-HTTLPR. Analysis of common genetic variants associated with depression, especially in the members of a family who had a previous history, might help in identifying the individuals at risk prior to the onset of depression.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi 221 005, India. madhubhu09@gmail.com.
authors.forename: Madhumita
authors.initials: M
authors.lastname: Roy
authors.forename: Madhu G
authors.initials: MG
authors.lastname: Tapadia
authors.forename: Shobhna
authors.initials: S
authors.lastname: Joshi
authors.forename: Biplob
authors.initials: B
authors.lastname: Koch
mesh_terms: D000293:Adolescent; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003863:Depression / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009473:Neuronal Plasticity / Q000235:genetics; D012307:Risk Factors; D012701:Serotonin / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics* / Q000503:physiopathology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; C579455:BDNF protein, human