title: On separability of A-phases during the cyclic alternating pattern.
abstract: A statistical analysis of the separability of EEG A-phases, with respect to basal activity, is presented in this study. A-phases are short central events that build up the Cyclic Alternating Pattern (CAP) during sleep. The CAP is a brain phenomenon which is thought to be related to the construction, destruction and instability of sleep stages dynamics. From the EEG signals, segments obtained around the onset and offset of the A-phases were used to evaluate the separability between A-phases and basal sleep stage oscillations. In addition, a classifier was trained to separate the different A-phase types (A1, A2 and A3). Temporal, energy and complexity measures were used as descriptors for the classifier. The results show a percentage of separation between onset and preceding basal oscillations higher than 85 % for all A-phases types. For Offset separation from following baseline, the accuracy is higher than 80 % but specificity is around 75%. Concerning to A-phase type separation, A1-phase and A3-phase are well separated with accuracy higher than 80, while A1 and A2-phases show a separation lower than 50%. These results encourage the design of automatic classifiers for Onset detection and for separating among A-phases type A1 and A3. On the other hand, the A-phase Offsets present a smooth transition towards the basal sleep stage oscillations, and A2-phases are very similar to A1-phases, suggesting that a high uncertainty may exist during CAP annotation.
authors.forename: M O
authors.initials: MO
authors.lastname: Mendez
authors.forename: A
authors.initials: A
authors.lastname: Alba
authors.forename: I
authors.initials: I
authors.lastname: Chouvarda
authors.forename: G
authors.initials: G
authors.lastname: Milioli
authors.forename: A
authors.initials: A
authors.lastname: Grassi
authors.forename: M G
authors.initials: MG
authors.lastname: Terzano
authors.forename: L
authors.initials: L
authors.lastname: Parrino
mesh_terms: D000328:Adult; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012894:Sleep Stages / Q000502:physiology