title: A registry-based study of thyroid paraganglioma: histological and genetic characteristics.
abstract: The precise diagnosis of thyroid neoplasias will guide surgical management. Primary thyroid paraganglioma has been rarely reported. Data on prevalence, immunohistochemistry (IHC), and molecular genetics in a systematic series of such patients are pending. We performed a multinational population-based study on thyroid paraganglioma and analyzed prevalence, IHC, and molecular genetics. Patients with thyroid paraganglioma were recruited from the European-American-Head-and-Neck-Paraganglioma-Registry. Demographic and clinical data were registered. Histopathology and IHC were re-investigated. All patients with thyroid paraganglioma underwent molecular genetic analyses of the SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, RET, TMEM127, and MAX genes. Analyses included Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA) for detection of large rearrangements. Of 947 registrants, eight candidates were initially identified. After immunohistochemical analyses of these eight subjects, 5 (0.5%) were confirmed to have thyroid paraganglioma. IHC was positive for chromogranin, synaptophysin, and S-100 and negative for calcitonin in all five thyroid paragangliomas, whereas the three excluded candidate tumors stained positive for pan-cytokeratin, a marker excluding endocrine tumors. Germline variants, probably representing mutations, were found in four of the five confirmed thyroid paraganglioma cases, two each in SDHA and SDHB, whereas the excluded cases had no mutations in the tested genes. Thyroid paraganglioma is a finite entity, which must be differentiated from medullary thyroid carcinoma, because medical, surgical, and genetic management for each is different. Notably, approximately 80% of thyroid paragangliomas are associated with germline variants, with implications for additional tumors and a potential risk for the family. As opposed to sporadic tumors, surgical management and extent of resection are different for heritable tumors, each guided by the precise gene involved.
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Ernst
authors.initials: E
authors.lastname: von Dobschuetz
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Helena
authors.initials: H
authors.lastname: Leijon
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Camilla
authors.initials: C
authors.lastname: Schalin-Jäntti
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Francesca
authors.initials: F
authors.lastname: Schiavi
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Michael
authors.initials: M
authors.lastname: Brauckhoff
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Mariola
authors.initials: M
authors.lastname: Peczkowska
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Giovanna
authors.initials: G
authors.lastname: Spiazzi
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Serena
authors.initials: S
authors.lastname: Demattè
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Maria Enrica
authors.initials: ME
authors.lastname: Cecchini
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Paola
authors.initials: P
authors.lastname: Sartorato
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Jolanta
authors.initials: J
authors.lastname: Krajewska
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Kornelia
authors.initials: K
authors.lastname: Hasse-Lazar
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Roszkowska-Purska
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Elisa
authors.initials: E
authors.lastname: Taschin
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Angelica
authors.initials: A
authors.lastname: Malinoc
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Lars A
authors.initials: LA
authors.lastname: Akslen
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Johanna
authors.initials: J
authors.lastname: Arola
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Dariusz
authors.initials: D
authors.lastname: Lange
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Fassina
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Gianmaria
authors.initials: G
authors.lastname: Pennelli
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Mattia
authors.initials: M
authors.lastname: Barbareschi
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Jutta
authors.initials: J
authors.lastname: Luettges
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Aleksander
authors.initials: A
authors.lastname: Prejbisz
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Andrzej
authors.initials: A
authors.lastname: Januszewicz
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Tim
authors.initials: T
authors.lastname: Strate
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Birke
authors.initials: B
authors.lastname: Bausch
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Frederic
authors.initials: F
authors.lastname: Castinetti
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Barbara
authors.initials: B
authors.lastname: Jarzab
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Opocher
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Charis
authors.initials: C
authors.lastname: Eng
authors.affiliation: Section of Endocrine SurgeryDepartment of General, Visceral and Thoracic Surgery, Krankenhaus Reinbek, St. Adolf Stift, Academic Teaching Hospital University of Hamburg, Reinbek, GermanyDepartment of PathologyHelsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandFamilial Cancer Clinic and Onco-EndocrinologyVeneto Institute of Oncology, IRCCS, Padova, ItalyDepartment of Endocrine SurgeryUniversity of Bergen, Bergen, NorwayDepartment of HypertensionInstitute of Cardiology, Warsaw, PolandEndocrinologyDiabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyUnits of Internal MedicineSanta Chiara General Hospital, Trento, ItalyDepartment of Internal MedicineGeneral Hospital, Montebelluna, Treviso, ItalyDepartment of Nuclear Medicine and Endocrine OncologyMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Pathology and Laboratory DiagnosticsSkłodowska-Curie Memorial Institute of Oncology, Warsaw, PolandSection for Preventive MedicineDepartment of Nephrology and General Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, GermanySection for PathologyDepartment of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, NorwayDepartment of Tumor PathologyM.Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandSurgical Pathology and Cytopathology UnitDepartment of Medicine, DIMED, University of Padova, Padova, ItalyDepartment of PathologySanta Chiara Regional Hospital, Trento, ItalyDepartment of PathologyMarienkrankenhaus, Hamburg, GermanyDepartment of GastroenterologyAlbert-Ludwigs-University of Freiburg, Freiburg, GermanyDepartment of EndocrinologyLa Timone Hospital, Hopitaux de Marseille
authors.forename: Hartmut P H
authors.initials: HP
authors.lastname: Neumann
mesh_terms: D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000378:metabolism; D053379:Chromogranin A / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D042963:Electron Transport Complex II / Q000235:genetics; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010235:Paraganglioma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D015995:Prevalence; D012042:Registries; D009418:S100 Proteins / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000235:genetics; D016708:Synaptophysin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors
chemical_list: D053379:Chromogranin A; D004268:DNA-Binding Proteins; D009418:S100 Proteins; D016708:Synaptophysin; C504003:TTF1 protein, human; D014157:Transcription Factors; D007633:Keratins; D002116:Calcitonin; D042963:Electron Transport Complex II; C511268:SDHA protein, human; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase
keywords: molecular genetics; neuroendocrinology; thyroid