title: TLR3: a receptor that recognizes cell injury is essential for permeability barrier homeostasis following UV irradiation.
abstract: The cutaneous permeability barrier is essential for life and perturbations in this barrier are repaired rapidly. After minimal injury to the stratum corneum alterations in the calcium concentration in the outer epidermis are the primary signal inducing this repair response. In this issue, studies demonstrate that Toll-like receptor 3 has an important role in signaling permeability barrier repair following injury induced by UVB irradiation.
authors.affiliation: Metabolism Section, Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, USA. Electronic address: kenneth.feingold@ucsf.edu.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Feingold
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D012867:Skin / Q000528:radiation effects*; D051196:Toll-Like Receptor 3 / Q000502:physiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: C519703:TLR3 protein, mouse; D051196:Toll-Like Receptor 3