title: Global resource distribution: allocation of actin building blocks by profilin.
abstract: How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.
authors.affiliation: Biology Department, Brandeis University, Waltham, MA 02453, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Henty-Ridilla
authors.affiliation: Biology Department, Brandeis University, Waltham, MA 02453, USA. Electronic address: goode@brandeis.edu.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Goode
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D008297:Male; D051304:Profilins / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D051304:Profilins; D029702:Schizosaccharomyces pombe Proteins