title: Divergent approach to building a latrunculin family derived hybrid macrocyclic toolbox.
abstract: A divergent approach to obtain a latrunculin family based hybrid macrocyclic toolbox is developed. A practical, stereoselective synthesis of a common substructure present in latrunculin A and latrunculol A was achieved. This was further utilized in the macrocyclic diversity synthesis. The amino acid moiety embedded in the 15-membered macrocyclic ring allows for the exploration of various chiral side chains as one of the diversity sites.
authors.affiliation: Dr. Reddy's Institute of Life Sciences (DRILS) , University of Hyderabad Campus, Hyderabad 500046, India.
authors.forename: Madhu
authors.initials: M
authors.lastname: Aeluri
authors.forename: Bhanudas
authors.initials: B
authors.lastname: Dasari
authors.forename: Prabhat
authors.initials: P
authors.lastname: Arya
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides; D053778:Thiazolidines; C555732:latrunculol A; C037067:latrunculin A