title: Homeostatic control of memory cell progenitors in the natural killer cell lineage.
abstract: Recent studies have demonstrated that natural killer (NK) cells are able to undergo clonal expansion and contraction and to generate self-renewing memory cells after infection with mouse cytomegalovirus (MCMV). It is unclear whether all or only certain subsets preferentially contribute to the generation of memory NK cells. Here, we show that memory NK cells predominantly arise from killer cell lectin-like receptor G1 (KLRG1)-negative NK cell progenitors, whereas KLRG1-positive NK cells have limited capacity for expansion during infection with MCMV. Unexpectedly, the frequency of KLRG1-positive NK cells is significantly affected by the presence of T cells in the host and potentially by the host microbiota. Our findings demonstrate that excessive availability of interleukin (IL)-15 may erode the pool of memory progenitors, resulting in the decreased efficiency of memory generation in the NK cell lineage.
authors.affiliation: Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94127, USA.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kamimura
authors.affiliation: Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94127, USA. Electronic address: lewis.lanier@ucsf.edu.
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D007156:Immunologic Memory; D019409:Interleukin-15 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D037181:Lectins, C-Type; D051379:Mice; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D018398:Homeodomain Proteins; D019409:Interleukin-15; C451496:Klrg1 protein, mouse; D037181:Lectins, C-Type; D016693:Receptors, Antigen, T-Cell, alpha-beta; D011971:Receptors, Immunologic; C064658:RAG-1 protein