title: The drop that spilled the cup: acute myocardial infarction in a young woman with underlying thrombophilic polymorphisms and oral contraceptive use.
abstract: We present the case of a 28-year-old woman who was admitted to our cardiology unit for acute coronary syndrome. Her history was notable for cardiovascular disease familiarity, active smoking, and oral contraceptive use. On further analysis, she was noted to have thrombophilic polymorphisms involving the plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), and methylenetetrahydrofolate reductase (MTHFR) genes. We discuss the implications that these cofactors may have had in the genesis of the disease.
authors.affiliation: Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy ; Cardiac Intensive Care Unit, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy.
authors.forename: Nunzio
authors.identifier: 0000-0001-5412-0698
authors.initials: N
authors.lastname: Russo
authors.affiliation: Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy ; Cardiovascular Imaging, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy.
authors.forename: Enrico
authors.identifier: 0000-0003-1347-4689
authors.initials: E
authors.lastname: Franzì
authors.affiliation: Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy ; Cardiac Catheterization Lab, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Capilli
authors.affiliation: Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy.
authors.forename: Anella Antonietta
authors.initials: AA
authors.lastname: Patané
authors.affiliation: Vita-Salute San Raffaele University, San Raffaele Hospital, 58 Via Olgettina, 20132 Milan, Italy.
authors.forename: Silvia Paola
authors.identifier: 0000-0001-9137-9391
authors.initials: SP
authors.lastname: Russo
authors.affiliation: Unit of Cardiovascular Disease, Hospital San Vincenzo, Contrada Sirina, 98039 Taormina, Italy.
authors.forename: Rosario
authors.identifier: 0000-0003-4720-0272
authors.initials: R
authors.lastname: Evola