title: Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.
abstract: Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon.
  
  
  METHODS
  Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter-white matter boundary. We studied 5 AD and 5 healthy subjects with both (18)F-THK5117 (tau) and (11)C-Pittsburgh compound B (Aβ) PET.
  
  
  RESULTS
  On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects and for all regions, both before and after regionally adjusting for the nonspecific white matter binding of both tracers. The differential laminar pattern was validated through postmortem examination.
  
  
  CONCLUSIONS
  Within cortical lamina, distance measures may be of value in testing PET tracers for their anatomic selectivity.
authors.affiliation: Center for Brain Health, New York University, New York, New York Shandong University, Shandong, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Brain Health, New York University, New York, New York.
authors.forename: Wai
authors.initials: W
authors.lastname: Tsui
authors.affiliation: Center for Brain Health, New York University, New York, New York.
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.affiliation: Center for Brain Health, New York University, New York, New York Cornell University, Ithaca, New York.
authors.forename: Tracy
authors.initials: T
authors.lastname: Butler
authors.affiliation: Center for Brain Health, New York University, New York, New York.
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.affiliation: Center for Brain Health, New York University, New York, New York.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pirraglia
authors.affiliation: Cornell University, Ithaca, New York.
authors.forename: David
authors.initials: D
authors.lastname: Mozley
authors.affiliation: Cornell University, Ithaca, New York.
authors.forename: Shankar
authors.initials: S
authors.lastname: Vallabhajosula
authors.affiliation: Institute of Development, Aging, and Cancer, Sendai, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Harada
authors.affiliation: Cyclotron and Radioisotope Center, Sendai, Japan.
authors.forename: Shozo
authors.initials: S
authors.lastname: Furumoto
authors.affiliation: Institute of Development, Aging, and Cancer, Sendai, Japan.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Furukawa
authors.affiliation: Institute of Development, Aging, and Cancer, Sendai, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.affiliation: Institute of Development, Aging, and Cancer, Sendai, Japan.
authors.forename: Yukitsuka
authors.initials: Y
authors.lastname: Kudo
authors.affiliation: Institute of Development, Aging, and Cancer, Sendai, Japan Tohoku University School of Medicine, Sendai, Japan; and.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Okamura
authors.affiliation: Center for Brain Health, New York University, New York, New York The Steven and Alexandra Cohen Veterans Center at NYU, New York, New York mony.deleon@nyumc.org.
authors.forename: Mony J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D016875:tau Proteins / Q000737:chemistry*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D014408:Biomarkers, Tumor; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D016875:tau Proteins
keywords: PET; amyloid beta; neocortical binding; tau