title: Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp.
abstract: An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.
authors.affiliation: Department of Chemistry, Keio University , 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
authors.forename: Arihiro
authors.initials: A
authors.lastname: Iwasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Ohno
authors.forename: Shinpei
authors.initials: S
authors.lastname: Sumimoto
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Kim Anh
authors.initials: KA
authors.lastname: Nguyen
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008235:Lyngbya Toxins / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured
chemical_list: D055666:Lipopeptides; D008235:Lyngbya Toxins; C000596569:jahanyne