title: Outcomes following pacemaker implantation after transcatheter aortic valve implantation with CoreValve(®) devices: Results from the FRANCE 2 Registry.
abstract: OBJECTIVE
  Permanent pacemaker (PPM) implantation following high-degree atrioventricular block is frequently required after transcatheter aortic valve implantation (TAVI) using CoreValve(®) . Recent improvement of the delivery system (CoreValve Accutrak(®) ) aimed to ease delivery and reduce the PPM rate. Our study evaluated the incidences of PPM implantation following use of CoreValve(®) or CoreValve Accutrak(®) and the clinical outcome of these patients.
  
  
  RESULTS
  A total of 883 patients (82 ± 7 years; 41.3% female) with severe symptomatic aortic stenosis and self-expanding bioprosthesis implantation were included between January 2010 and October 2011 in 29 centers from the FRANCE 2 Registry. Follow-up data were available in 833 patients. CoreValve(®) and CoreValve Accutrak(®) were used in 343 (41.2%) and 490 (58.8%) patients, respectively. During a mean follow-up of 242 ± 179 days, all-cause mortality was similar in patients with versus without PPM implantation (16.3 vs. 16.9%, P = 0.832).There was no significant difference in the PPM incidence in CoreValve(®) and CoreValve Accutrak(®) patients (30.4% vs. 27.5%, P = 0.846).
  
  
  CONCLUSIONS
  PPM implantation remained frequent after TAVI using CoreValve Accutrak(®) . All-cause mortality was similar in patients with or without PPM implantation. The new device failed to show a significant decrease in PPM implantation incidence after TAVI. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Gauthier
authors.initials: G
authors.lastname: Mouillet
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lellouche
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Oguri
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Dubois-Rande
authors.affiliation: Cardiology Department, Centre Hospitalier Universitaire De Lille, Lille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Van Belle
authors.affiliation: Cardiology Department, Centre Hospitalier Universitaire De Brest, Hôpital De La Cavale Blanche, Brest, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Gilard
authors.affiliation: Cardiac Surgery Unit, Centre Hospitalier Universitaire De Limoges, Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Laskar
authors.affiliation: Cardiology Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux De Paris & INSERM U 955, Creteil, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Teiger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D065467:Transcatheter Aortic Valve Replacement / Q000295:instrumentation*; D016896:Treatment Outcome
keywords: aortic valve stenosis; pacemaker; transcatheter aortic valve implantation