title: Computed tomographic features predictive of local recurrence in patients with early stage lung cancer treated with stereotactic body radiation therapy.
abstract: BACKGROUND
  The objective of this study is to identify computed tomography (CT) features of local recurrence (LR) after stereotactic body radiation therapy (SBRT) for lung cancer.
  
  
  METHODS
  Two hundred eighteen patients underwent SBRT for lung cancer from January 1st, 2006 to March 1st, 2011. Signs of LR recorded: opacity with new bulging margin, opacification of air bronchograms, enlarging pleural effusion, new or enlarging mass, and increased lung density at the treatment site.
  
  
  RESULTS
  A new bulging margin at the treatment site was the only feature significantly associated with LR (P<.005).
  
  
  CONCLUSIONS
  Most CT features classically associated with LR following conventional radiation therapy are unreliable for predicting LR following SBRT.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), New York.
authors.forename: Darragh
authors.initials: D
authors.lastname: Halpenny
authors.affiliation: Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.
authors.forename: Carole A
authors.initials: CA
authors.lastname: Ridge
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), New York.
authors.forename: Sara
authors.initials: S
authors.lastname: Hayes
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
authors.forename: Junting
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
authors.forename: Chaya S
authors.initials: CS
authors.lastname: Moskowitz
authors.affiliation: Department of Thoracic Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rimner
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center (MSKCC), New York. Electronic address: ginsberm@MSKCC.ORG.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Ginsberg
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000601:surgery; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D016634:Radiosurgery; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Computed tomography; Local recurrence; Lung cancer; Stereotactic body radiation therapy