title: Lectins with anti-HIV activity: a review.
abstract: Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrianthus holstii lectin, Narcissus pseudonarcissus lectin, and Urtica diocia agglutinin. The anti-HIV algal lectins comprise Boodlea coacta lectin, Griffithsin, Oscillatoria agardhii agglutinin. The anti-HIV cyanobacterial lectins are cyanovirin-N, scytovirin, Microcystis viridis lectin, and microvirin. Actinohivin is an anti-HIV actinomycete lectin. The anti-HIV worm lectins include Chaetopterus variopedatus polychaete marine worm lectin, Serpula vermicularis sea worm lectin, and C-type lectin Mermaid from nematode (Laxus oneistus). The anti-HIV nonpeptidic lectin mimics comprise pradimicins and benanomicins. Their anti-HIV mechanisms are discussed.
authors.affiliation: Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK Leiden, The Netherlands. ouafae@live.nl.
authors.forename: Ouafae
authors.initials: O
authors.lastname: Akkouh
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. b021770@mailserv.cuhk.edu.hk.
authors.forename: Tzi Bun
authors.initials: TB
authors.lastname: Ng
authors.affiliation: Department of Biochemistry, Manipur University, Canchipur, Imphal 795003, India. sunil_senjam@rediffmail.com.
authors.forename: Senjam Sunil
authors.initials: SS
authors.lastname: Singh
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. ycm1907@gmail.com.
authors.forename: Cuiming
authors.initials: C
authors.lastname: Yin
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. s1155009788@mailserv.cuhk.edu.hk.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Dan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. bomberharo@gmail.com.
authors.forename: Yau Sang
authors.initials: YS
authors.lastname: Chan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. b132588@mailserv.cuhk.edu.hk.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Pan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. chifaicheung@cuhk.edu.hk.
authors.forename: Randy Chi Fai
authors.initials: RC
authors.lastname: Cheung
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry; D035264:Flowers / Q000737:chemistry; D006376:Helminths / Q000737:chemistry; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D037121:Plant Lectins / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D037102:Lectins; D037121:Plant Lectins