title: Double-strand break repair on sex chromosomes: challenges during male meiotic prophase.
abstract: During meiotic prophase, DNA double-strand break (DSB) repair-mediated homologous recombination (HR) occurs for exchange of genetic information between homologous chromosomes. Unlike autosomes or female sex chromosomes, human male sex chromosomes X and Y share little homology. Although DSBs are generated throughout male sex chromosomes, homologous recombination does not occur for most regions and DSB repair process is significantly prolonged. As a result, male sex chromosomes are coated with many DNA damage response proteins and form a unique chromatin structure known as the XY body. Interestingly, associated with the prolonged DSB repair, transcription is repressed in the XY body but not in autosomes, a phenomenon known as meiotic sex chromosome inactivation (MSCI), which is critical for male meiosis. Here using mice as model organisms, we briefly summarize recent progress on DSB repair in meiotic prophase and focus on the mechanism and function of DNA damage response in the XY body.
authors.affiliation: a Women's Hospital ; School of Medicine ; Zhejiang University ; Hangzhou , Zhejiang , China.
authors.forename: Lin-Yu
authors.initials: LY
authors.lastname: Lu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Yu
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003434:Crossing Over, Genetic / Q000502:physiology*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D008297:Male; D051379:Mice; D008954:Models, Biological; D011418:Prophase / Q000502:physiology*; D012730:Sex Chromosomes / Q000473:pathology / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases
chemical_list: D002352:Carrier Proteins; C404219:Rnf19 protein, mouse; D044767:Ubiquitin-Protein Ligases
keywords: XY body; double-strand break repair; homologous recombination; meiosis; meiotic sex chromosome inactivation