title: Recent Advance in Drug Development of Squamous Cell Carcinoma.
abstract: Squamous cell carcinoma (SCC) has a high worldwide incidence that is commonly seen as head and neck cancers, esophageal cancers, and non-small cell lung cancers. There is a poor prognosis for SCC due to potential recurrence and its metastatic tendency so the 5-year survival rate is very low. Target therapy is a novel and promising treatment strategy exhibiting great anti-tumor effects and survival benefits in SCC. This review summarizes current treatment strategies from clinical and experimental studies, including the agents targeting epidermal growth factor receptors, RNA polymerase, toll-like receptors, p38α MAPK, CXCR, and the related combination therapy regimens. However, there are still many challenges we have to face. It is a burning need to improve the development and availability of drug formulations.
authors.forename: Jun
authors.initials: J
authors.lastname: Lei
authors.forename: Bing
authors.initials: B
authors.lastname: Fu
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.forename: Guanxiu
authors.initials: G
authors.lastname: Tang
authors.forename: Shujuan
authors.initials: S
authors.lastname: Zhu
authors.forename: Chunli
authors.initials: C
authors.lastname: Yan
authors.affiliation: Central South University. qyonghe@126.com.
authors.forename: Quanyong
authors.initials: Q
authors.lastname: He
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D048308:Mitogen-Activated Protein Kinase 14 / Q000037:antagonists & inhibitors; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D054387:Receptors, CXCR / Q000037:antagonists & inhibitors; D051193:Toll-Like Receptors / Q000819:agonists
chemical_list: D054387:Receptors, CXCR; D051193:Toll-Like Receptors; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D048308:Mitogen-Activated Protein Kinase 14; D012321:DNA-Directed RNA Polymerases