title: The role of hepcidin in chronic mild stress-induced depression.
abstract: Depression is one of the most prevalent challenges of mental conditions. Yet its exact etiology has not been clear. Chronic stress increases the production of cytokines, which can lead to depression. Hepcidin, an iron modulator, is involved in the inflammation process as well as iron homeostasis. This study was designed to investigate the role of hepcidin, on stress-induced depression. 60 male wistar rats were entered the experiment. We used a chronic unpredictable mild stress (for 28 days) as a rat model of depression. In stressed group, three subgroups were treated with three different doses of dalteparin (a hepcidin inhibitor): 70IU/kg, 100IU/kg and 140IU/kg daily, for 4 weeks. The animals in the stressed group had more depressive-like behavior than the control group. Moreover, chronic mild stress produced an increased serum interleukin-6 levels. These effects were accompanied by an obvious increase in hepcidin mRNA level and iron content in the hippocampus. These changes were blocked by the injection of dalteparin. In conclusion, inhibition of hepcidin may reduce many pathological changes seen in stress-induced depressive disorders.
authors.affiliation: Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Farajdokht
authors.affiliation: Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mansoureh
authors.initials: M
authors.lastname: Soleimani
authors.affiliation: Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Mehrpouya
authors.affiliation: Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Barati
authors.affiliation: Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: arezoonahavandi1999@gmail.com.
authors.forename: Arezo
authors.initials: A
authors.lastname: Nahavandi
mesh_terms: D000818:Animals; D002908:Chronic Disease; D017985:Dalteparin / Q000494:pharmacology; D003863:Depression / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D064451:Hepcidins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications / Q000276:immunology / Q000378:metabolism*
chemical_list: D064451:Hepcidins; D015850:Interleukin-6; D012333:RNA, Messenger; D007501:Iron; D017985:Dalteparin
keywords: Brain iron; Chronic mild stress; Dalteparin; Depression; Hepcidin; IL-6