title: Mycobacterium haemophilum bone and joint infection in HIV/AIDS: case report and literature review.
abstract: We report a case of disseminated Mycobacterium haemophilum osteomyelitis in a patient with advanced HIV infection, who later developed recurrent immune reconstitution inflammatory syndrome after commencement of antiretroviral therapy. We review previous reports of M. haemophilum bone and joint infection associated with HIV infection and describe the management of M. haemophilum-associated immune reconstitution inflammatory syndrome, including the role of surgery as an adjunctive treatment modality and the potential drug interactions between antiretroviral and antimycobacterial agents.
authors.affiliation: Departments of Microbiology, Monash Health, Melbourne, Australia Infectious Diseases, Monash Health, Melbourne, VIC, Australia gailb.cross@gmail.com.
authors.forename: Gail B
authors.initials: GB
authors.lastname: Cross
authors.affiliation: Infectious Diseases, Monash Health, Melbourne, VIC, Australia.
authors.forename: Quynh
authors.initials: Q
authors.lastname: Le
authors.affiliation: Departments of Microbiology, Monash Health, Melbourne, Australia.
authors.forename: Brooke
authors.initials: B
authors.lastname: Webb
authors.affiliation: Infectious Diseases, Monash Health, Melbourne, VIC, Australia.
authors.forename: Grant A
authors.initials: GA
authors.lastname: Jenkin
authors.affiliation: Departments of Microbiology, Monash Health, Melbourne, Australia Infectious Diseases, Monash Health, Melbourne, VIC, Australia Department of Medicine, Monash Health, Melbourne, VIC, Australia.
authors.forename: Tony M
authors.initials: TM
authors.lastname: Korman
authors.affiliation: Departments of Microbiology, Monash Health, Melbourne, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Francis
authors.affiliation: Infectious Diseases, Monash Health, Melbourne, VIC, Australia Department of Medicine, Monash Health, Melbourne, VIC, Australia Department of Infectious Diseases, Monash University, VIC, Australia.
authors.forename: Ian
authors.initials: I
authors.lastname: Woolley
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D000843:Ankle Joint; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003646:Debridement; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000382:microbiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D018393:Mycobacterium haemophilum / Q000235:genetics / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D016133:Polymerase Chain Reaction; D013717:Tenosynovitis / Q000382:microbiology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents
keywords: HIV/AIDS; Mycobacterium haemophilum; immune reconstitution inflammatory syndrome; non-tuberculous mycobacteria; osteomyelitis