title: The role of inflammatory cytokines as key modulators of neurogenesis.
abstract: Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.
authors.affiliation: Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Borsini
authors.affiliation: Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Zunszain
authors.affiliation: Centre for the Cellular Basis of Behaviour, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, London, UK.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Thuret
authors.affiliation: Section of Stress, Psychiatry and Immunology & Perinatal Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, UK. Electronic address: carmine.pariante@kcl.ac.uk.
authors.forename: Carmine M
authors.initials: CM
authors.lastname: Pariante
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*
chemical_list: D016207:Cytokines
keywords: cell differentiation; cytokines; immune activation; inflammation; interleukins; neurogenesis