title: An adaptive phase-locking insight to unravel mRNAs synchrony from microarray experiments.
abstract: A bulk mRNA expression time course can slow or advance modulating in phase the averaged expression of each gene within the cell-cycle. This is also a synchronism induced at the cycle start to recognize periodic genes. Consistent with the above, a novel adaptive phase-locking insight into microarray experiment is provided. The budding-yeast expression of the major role in the cell-division-cycle could be clustered in phase by a new amplitude noise immune approach which compares well to meta-analysis of the web Cyclebase and to previous results in the field. The new approach to timing elucidation seems to be well matched to cellular phenomena and might be promising as the most accurate ever applied in Fourier context.
authors.forename: Mariusz Leslaw
authors.initials: ML
authors.lastname: Zoltowski
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division; D015966:Gene Expression Regulation, Fungal; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism
chemical_list: D012333:RNA, Messenger