title: A modular DNA origami-based enzyme cascade nanoreactor.
abstract: In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions.
authors.affiliation: Biohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, FI-00076 Aalto, Finland. mauri.kostiainen@aalto.fi.
authors.forename: Veikko
authors.initials: V
authors.lastname: Linko
authors.forename: Marika
authors.initials: M
authors.lastname: Eerikäinen
authors.forename: Mauri A
authors.initials: MA
authors.lastname: Kostiainen
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism*; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D004247:DNA; D005949:Glucose Oxidase; D006735:Horseradish Peroxidase