title: The dynamic changes of anti-Mullerian hormone and inhibin B during controlled ovarian hyperstimulation in decreased ovarian reserve women and the effect on clinical outcome.
abstract: OBJECTIVE
  To investigate the dynamics of anti-Mullerian hormone (AMH) and inhibin B (INHB) levels during controlled ovarian hyperstimulation (COH) in women with decreased ovarian reserve (DOR), and assess the effect of these dynamic changes on the prediction of clinical outcome in in-vitro fertilization (IVF).
  
  
  METHODS
  A total of 124 women undergoing IVF cycles were divided into normal ovarian reserve (NOR) and DOR groups. AMH and INHB levels were measured in serum on menstrual cycle day 2 or 3 (D2/3), day 5 of stimulation (D5), hCG day (D-hCG) and follicular fluid (FF) on oocyte retrieval day.
  
  
  RESULTS
  Serum AMH levels were gradually decreased while INHB levels were gradually increased from D2/3 to D-hCG during the COH in both groups. Serum AMH, INHB levels on D2/3 and FF AMH, INHB levels were highly positively correlated with AFC and oocytes retrieval. Multivariate logistic regression analysis revealed that clinical pregnancy did not directly correlate with serum and FF AMH and INHB levels.
  
  
  CONCLUSIONS
  Serum AMH and INHB levels were not directly related to clinical pregnancy, dynamic serum AMH and IHNB levels were positively correlated with COH outcomes.
authors.affiliation: Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital , Capital Medical University, Beijing , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Mingyue
authors.initials: M
authors.lastname: Nie
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaokui
authors.initials: X
authors.lastname: Yang
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D065851:Ovarian Reserve / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone
keywords: Anti-Mullerian hormone; controlled ovarian hyperstimulation; decreased ovarian reserve; inhibin B