title: Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry.
abstract: The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.
authors.affiliation: CIQUP/Departamento de Química e Bioquímica Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal. fborges@fc.up.pt.
authors.forename: F
authors.initials: F
authors.lastname: Cagide
authors.forename: T
authors.initials: T
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Reis
authors.forename: A
authors.initials: A
authors.lastname: Gaspar
authors.forename: F
authors.initials: F
authors.lastname: Borges
authors.forename: L R
authors.initials: LR
authors.lastname: Gomes
authors.forename: J N
authors.initials: JN
authors.lastname: Low
mesh_terms: D002839:Chromans / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D002839:Chromans; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase