title: Complete genome sequence of two rabbit hemorrhagic disease virus variant b isolates detected on the Iberian Peninsula.
abstract: We report the complete genome sequences of two isolates (RHDV-N11 and CBVal16) of variant rabbit hemorrhagic disease virus (RHDVb). Isolate N11 was detected in young domestic animals during a rabbit hemorrhagic disease (RHD) outbreak that occurred in 2011 on a rabbit farm in Navarra, Spain, while CBVal16 was isolated from a wild rabbit found dead in Valpaços, Northern Portugal, a year later. The viral sequences reported show 84.8-85.1 % and 78.3-78.5 % identity to RHDVAst/89 and RCV-A1 MIC-07, representative members of the pathogenic genogroup 1 RHDV and apathogenic rabbit calicivirus, respectively. In comparison with other RHDV isolates belonging to the previously known genogroups 1-6, RHDVb shows marked phenotypic differences, as it causes disease preferentially in young rabbits under 40 days of age and shows modified red blood cell agglutination profiles as well as antigenic differences that allow this variant to escape protection by the currently available vaccines.
authors.affiliation: Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, Oviedo, Spain, daltonkevin@uniovi.es.
authors.forename: K P
authors.initials: KP
authors.lastname: Dalton
authors.forename: J
authors.initials: J
authors.lastname: Abrantes
authors.forename: A M
authors.initials: AM
authors.lastname: Lopes
authors.forename: I
authors.initials: I
authors.lastname: Nicieza
authors.forename: Á L
authors.initials: ÁL
authors.lastname: Álvarez
authors.forename: P J
authors.initials: PJ
authors.lastname: Esteves
authors.forename: F
authors.initials: F
authors.lastname: Parra
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000662:veterinary / Q000821:virology; D016000:Cluster Analysis; D023061:Gene Order; D016679:Genome, Viral; D006386:Hemagglutination Tests; D017929:Hemorrhagic Disease Virus, Rabbit / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D011174:Portugal; D012367:RNA, Viral / Q000235:genetics*; D011817:Rabbits; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013030:Spain; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins