title: Ultra-long term stability of single units using chronically implanted multielectrode arrays.
abstract: Recordings from chronically implanted multielectrode arrays have become prevalent in both neuroscience and neural engineering experiments. To date, however, the extent to which populations of single-units remain stable over long periods of time has not been well characterized. In this study, neural activity was recorded from a Utah multielectrode array implanted in the primary motor cortex of a rhesus macaque during 18 recording sessions spanning nine months. We found that 67% of the units were stable through the first 15 days, 31% of units were stable through 47 days, 21% of units were stable through 106 days, and 8% of units were stable over 9 months. Thus not only were units stable over a timescale of several months, but units stable over 2 months were more likely to remain stable in the next 2 months.
authors.forename: Mukta
authors.initials: M
authors.lastname: Vaidya
authors.forename: Adam
authors.initials: A
authors.lastname: Dickey
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Best
authors.forename: Josh
authors.initials: J
authors.lastname: Coles
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Balasubramanian
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Suminski
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Hatsopoulos
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal; D062207:Brain-Computer Interfaces; D002470:Cell Survival; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005260:Female; D008253:Macaca mulatta; D009044:Motor Cortex / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012371:Robotics; D012815:Signal Processing, Computer-Assisted