title: Pre-treatment apparent diffusion coefficient mapping: differentiation of benign from malignant laryngeal lesions.
abstract: OBJECTIVE
  To determine whether a threshold apparent diffusion coefficient value may help to differentiate laryngeal carcinomas from benign lesions.
  
  
  METHODS
  Fifty-three patients with laryngeal masses were recruited; four of them were excluded because of susceptibility artefacts. In the remaining 49 patients, the pathological results showed 32 laryngeal carcinomas and 17 benign lesions. The diagnostic value of diffusion-weighted magnetic resonance imaging for the identification of malignant lesions was determined. In addition, the agreement between diffusion-weighted magnetic resonance imaging and histopathology was assessed. Moreover, the sensitivity, specificity, and negative and positive predictive values of the apparent diffusion coefficient in detecting benign and malignant lesions were analysed. An apparent diffusion coefficient histogram was also produced.
  
  
  RESULTS
  An apparent diffusion coefficient value of 1.1 × 10-3 mm2/second produced the best result when used as the cut-off point to differentiate malignant from benign masses.
  
  
  CONCLUSIONS
  An apparent diffusion coefficient threshold of 1.1 × 10-3 mm2/second is optimal for distinguishing laryngeal carcinomas from benign lesions. Apparent diffusion coefficient values were lower for patients with laryngeal carcinomas than for those with benign lesions.
authors.affiliation: Department of Otorhinolaryngology,Ain Shams University,Cairo,Egypt.
authors.forename: M S
authors.initials: MS
authors.lastname: Taha
authors.affiliation: Department of Otorhinolaryngology,Ain Shams University,Cairo,Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Amir
authors.affiliation: Department of Otorhinolaryngology,Ain Shams University,Cairo,Egypt.
authors.forename: O
authors.initials: O
authors.lastname: Hassan
authors.affiliation: Department of Otorhinolaryngology,Ain Shams University,Cairo,Egypt.
authors.forename: R
authors.initials: R
authors.lastname: Sabra
authors.affiliation: Department of Radiodiagnosis,Ain Shams University,Cairo,Egypt.
authors.forename: T
authors.initials: T
authors.lastname: Taha
authors.affiliation: Department of Otorhinolaryngology,Ain Shams University,Cairo,Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Riad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Diffusion Weighted MRI