title: Effect of atorvastatin on memory in albino mice.
abstract: OBJECTIVE
  The aim and objective of the present study was to evaluate the effect of atorvastatin on learning and memory in albino mice.
  
  
  METHODS
  Thirty Swiss albino mice were divided into 5groups (n=6). In group2, group4 and group5 hyperlipidemia was induced by high fat diet (HFD) orally for 28days. Atrorvastatin was given to group3, group4 and group5 orally for 14 d. Learning and memory was evaluated with Hebb Williams's maze, Elevated plus maze, Y maze and Step through latency. Continuous data were analyzed by one way ANOVA followed by Scheffe multiple range test, discrete data were analyzed by Kruskal - Wallis test. The level of significance was 5% (p ≤ 0.05).
  
  
  CONCLUSIONS
  HFD treatment had shown significant increase in body weight, significant impairment in learning and memory (p < 0.05). Only atorvastatin treated group had shown better learning and memory in comparison to HFD group. Atorvastatin 10mg/kg and 20 mg/kg had reversed the HFD induced impairment of learning and memory but there was no significant difference between the doses (p > 0.05).
authors.affiliation: Senior Resident, Department of Pharmacology, Siddhartha Medical College , Vijayawada, Krishna Dt., Andhra Pradesh, India .
authors.forename: Rinku Rani
authors.initials: RR
authors.lastname: Biswas
authors.affiliation: Professor & HOD, Department of Pharmacology, NRI Medical College , Chinakakani, Guntur Dt, Andhra Pradesh, India .
authors.forename: Das
authors.initials: D
authors.lastname: M C
authors.affiliation: Assosiate Professor, Department of Pharmacology, NRI Medical College , Chinakakani, Guntur Dt, Andhra Pradesh, India .
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Rao A S R
authors.affiliation: Tutor, Department of Pharmacology, NRI Medical College , Chinakakani, Guntur Dt, Andhra Pradesh, India .
authors.forename: Sldv Ramana Murty
authors.initials: SR
authors.lastname: Kadali
keywords: Atorvastatin; Elevated plus maze; Hebb williams’s maze; High fat diet; Learning and memory; Step through latency; Y maze