title: [The nucleus origin of acoustically evoked short latency negative response in guinea pigs].
abstract: OBJECTIVE
  This study established a model of acoustically evoked short latency negative response (ASNR) in guinea pigs. Stereotaxic coordinate guided electrolytic lesion was applied to animal brainstem nuclei, the vestibular nucleus and the cochlear nucleus, to define the neural origin of ASNR.
  
  
  METHODS
  Twenty four guinea pigs with normal hearing were randomly divided into the control group (8 subjects, 16 ears) and the deafened group (16 subjects, 32 ears). Each animal experienced the auditory brainstem response (ABR) test. According to the presence of ASNR, the deafened group was further divided into ASNR group and non-ASNR group. Electrolytic lesion was conducted to the vestibular nucleus and cochlear nucleus respectively, followed by ABR test. The lesion structures were verified by brainstem slice and microscope.
  
  
  RESULTS
  In deafened group, the ASNR was elicited in 10 ears (31.3%). The ASNR was eliminated due to the electrolytic destruction to the vestibular nucleus, but it remained unchanged after the same procedure to the cochlear nucleus.
  
  
  CONCLUSIONS
  It is clear that the ASNR is originated from the vestibular nucleus, but not the cochlear nucleus.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Wenqin
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Email: nongdx@gxmu.edu.cn.
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Nong
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Anzhou
authors.initials: A
authors.lastname: Tang
mesh_terms: D000162:Acoustics; D000818:Animals; D017626:Cochlear Nucleus; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs; D011930:Reaction Time; D012444:Saccule and Utricle; D014726:Vestibular Nuclei