title: Circulating tumour cells and circulating nucleic acids as a measure of tumour dissemination in non-metastatic colorectal cancer surgery.
abstract: There is accumulating evidence for circulating tumour cells (CTCs) and circulating tumour nucleic acids (ctNAs) as prognostic and predictive biomarkers in colorectal cancer. Their role in the perioperative setting is evolving. These blood-borne biomarkers can potentially demonstrate tumour dissemination at time of colorectal cancer surgery and estimate the completeness of a surgical resection. CTCs and circulating ctNA levels at time of surgery, and persistent levels post-surgery, may correlate with poorer patient outcomes. These biomarkers can be utilised to refine surgical techniques to minimise tumour dissemination and determine the need for adjuvant therapy.
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia; Centre for Oncology Education and Research Translation (CONCERT), Liverpool 2170, Australia. Electronic address: stephanie.lim@sswahs.nsw.gov.au.
authors.forename: S H
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Centre for Oncology Education and Research Translation (CONCERT), Liverpool 2170, Australia; Liverpool Clinical School, University of Western Sydney, Liverpool 2170, Australia.
authors.forename: K J
authors.initials: KJ
authors.lastname: Spring
authors.affiliation: Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia; Centre for Oncology Education and Research Translation (CONCERT), Liverpool 2170, Australia; Liverpool Clinical School, University of Western Sydney, Liverpool 2170, Australia.
authors.forename: P
authors.initials: P
authors.lastname: de Souza
authors.affiliation: Centre for Oncology Education and Research Translation (CONCERT), Liverpool 2170, Australia; Liverpool Clinical School, University of Western Sydney, Liverpool 2170, Australia; Department of Colorectal Surgery, Liverpool Hospital, 2170, Australia.
authors.forename: S
authors.initials: S
authors.lastname: MacKenzie
authors.affiliation: Centre for Oncology Education and Research Translation (CONCERT), Liverpool 2170, Australia; Liverpool Clinical School, University of Western Sydney, Liverpool 2170, Australia; Department of Colorectal Surgery, Liverpool Hospital, 2170, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Bokey
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood* / Q000601:surgery; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D006801:Humans; D009362:Neoplasm Metastasis; D018365:Neoplasm, Residual; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D009696:Nucleic Acids / Q000097:blood*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D009696:Nucleic Acids
keywords: Circulating tumour cells; Colorectal cancer; Surgery; Tumour dissemination