title: A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies.
abstract: OBJECTIVE
  Dermatologic adverse events (dAEs) in cancer treatment are frequent with the use of targeted therapies. These dAEs have been shown to have significant impact on health-related quality of life (HRQoL). While standardized assessment tools have been developed for physicians to assess severity of dAEs, there is a discord between objective and subjective measures. The identification of patient-reported outcome (PRO) instruments useful in the context of targeted cancer therapies is therefore important in both the clinical and research settings for the overall evaluation of dAEs and their impact on HRQoL.
  
  
  METHODS
  A comprehensive, systematic literature search of published articles was conducted by two independent reviewers in order to identify PRO instruments previously utilized in patient populations with dAEs from targeted cancer therapies. The identified PRO instruments were studied to determine which HRQoL issues relevant to dAEs were addressed, as well as the process of development and validation of these instruments.
  
  
  RESULTS
  Thirteen articles identifying six PRO instruments met the inclusion criteria. Four instruments were general dermatology (Skindex-16©, Skindex-29©, Dermatology Life Quality Index (DLQI), and DIELH-24) and two were symptom-specific (functional assessment of cancer therapy-epidermal growth factor receptor inhibitor-18 (FACT-EGFRI-18) and hand-foot syndrome 14 (HFS-14)).
  
  
  CONCLUSIONS
  While there are several PRO instruments that have been tested in the context of targeted cancer therapy, additional work is needed to develop new instruments and to further validate the instruments identified in this study in patients receiving targeted therapies.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
authors.forename: Michael C
authors.initials: MC
authors.lastname: Cameron
authors.forename: Benjamin
authors.initials: B
authors.lastname: Garden
authors.forename: Christine B
authors.initials: CB
authors.lastname: Boers-Doets
authors.forename: Katja
authors.initials: K
authors.lastname: Schindler
authors.forename: Joel B
authors.initials: JB
authors.lastname: Epstein
authors.forename: Jennifer
authors.initials: J
authors.lastname: Choi
authors.forename: Laura
authors.initials: L
authors.lastname: Beamer
authors.forename: Eric
authors.initials: E
authors.lastname: Roeland
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Russi
authors.forename: René-Jean
authors.initials: RJ
authors.lastname: Bensadoun
authors.forename: Yi Ling
authors.initials: YL
authors.lastname: Teo
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Chan
authors.forename: Vivianne
authors.initials: V
authors.lastname: Shih
authors.forename: Jane
authors.initials: J
authors.lastname: Bryce
authors.forename: Judith
authors.initials: J
authors.lastname: Raber-Durlacher
authors.forename: Peter Arne
authors.initials: PA
authors.lastname: Gerber
authors.forename: César O
authors.initials: CO
authors.lastname: Freytes
authors.forename: Bernardo
authors.initials: B
authors.lastname: Rapoport
authors.forename: Nicole
authors.initials: N
authors.lastname: LeBoeuf
authors.forename: Vincent
authors.initials: V
authors.lastname: Sibaud
authors.forename: Mario E
authors.initials: ME
authors.lastname: Lacouture
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects; D009369:Neoplasms / Q000188:drug therapy*; D063868:Patient Outcome Assessment; D011788:Quality of Life; D012871:Skin Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents