title: [Contrast-enhanced ultrasonography findings for papillary thyroid carcinoma and its pathological bases ].
abstract: OBJECTIVE
  To investigate the findings of contrast enhanced ultrasound for papillary thyroid carcinoma and its pathological bases.
  
  
  METHODS
  Seventy two (72) patients with thyroid nodules underwent routine conventional ultrasound and color Doppler examination, and 86 nodules with TI RADS 3 were examined by contrast-enhanced ultrasound (CEUS . Histopathological examination was kept as standard reference and the findings of CEUS were analyzed. Pathological studies of all nodules were made after post-operative CD34 immunohistochemistry staining examination.
  
  
  RESULTS
  Of the total 86 nodules, Adler CDFl classification grades were: grade 0-26. grade I-34. grade II-23 and grade III-3 nodules respectively. Enhancement pattern on CEUS showed that there was low enhancement on 71 nodules, iso enhancement on 12 and high enhancement on 3 nodules. The differences of echo mean intensity. the peak intensity, area under the curve for enhancement intensity and CD34 count between the nodules and surrounding tissue were statistical significant (P < 0. 001).
  
  
  CONCLUSIONS
  Low enhancement pattern on CEUS is the most common finding for papillary thyroid carcinoma, which is related to the difference of microvessel density between the nodules and surrounding tissues in papillary thyroid carcinoma.
authors.affiliation: Department of Ultrasound,  West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Bu-yun
authors.initials: BY
authors.lastname: Ma
authors.forename: Ya
authors.initials: Y
authors.lastname: Jin
authors.forename: Purajuly Shyam
authors.initials: PS
authors.lastname: Suntdar
authors.forename: Hai-na
authors.initials: HN
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jie-hong
authors.initials: JH
authors.lastname: Zhou
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D002291:Carcinoma, Papillary; D003287:Contrast Media; D006801:Humans; D007150:Immunohistochemistry; D011184:Postoperative Period; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media