title: What the Eczema Area and Severity Index score tells us about the severity of atopic dermatitis: an interpretability study.
abstract: BACKGROUND
  The Eczema Area and Severity Index (EASI) is an investigator-assessed instrument measuring the severity of clinical signs in atopic dermatitis (AD). The EASI was identified as one of the best-validated outcome measures for AD; however, no previous studies address how to interpret the EASI score for clinical use.
  
  
  OBJECTIVE
  To evaluate the interpretability and the ease of use of the EASI.
  
  
  METHODS
  A retrospective analysis of paediatric and adult patients with AD was performed. Interpretability was evaluated by stratifying the EASI scores according to the Investigator's Global Assessment. The severity strata displaying the highest kappa coefficient of agreement were then selected as the recommended EASI band. The time to administer the EASI was recorded in a subgroup of patients.
  
  
  RESULTS
  The suggested severity strata for the EASI are as follows: 0 = clear; 0·1-1·0 = almost clear; 1·1-7·0 = mild; 7·1-21·0 = moderate; 21·1-50·0 = severe; 50·1-72·0 = very severe (κ = 0·75). The EASI was also found to be acceptable in terms of ease of use, with assessments by trained investigators taking approximately 6 min.
  
  
  CONCLUSIONS
  Our study provides the first guide for interpreting the EASI score. It enables translation of the EASI numerical output into an AD global severity state that should be more meaningful to providers and patients. Along with a short administration time, the EASI demonstrates adequate feasibility, further supporting its use in clinical trials.
authors.affiliation: Department of Dermatology, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR, 97239-4501, U.S.A.
authors.forename: Y A
authors.initials: YA
authors.lastname: Leshem
authors.affiliation: Department of Dermatology, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR, 97239-4501, U.S.A.
authors.forename: T
authors.initials: T
authors.lastname: Hajar
authors.affiliation: Department of Dermatology, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR, 97239-4501, U.S.A.
authors.forename: J M
authors.initials: JM
authors.lastname: Hanifin
authors.affiliation: Department of Dermatology, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR, 97239-4501, U.S.A.
authors.forename: E L
authors.initials: EL
authors.lastname: Simpson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003876:Dermatitis, Atopic / Q000175:diagnosis*; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult