title: Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
abstract: OBJECTIVE
  This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population.
  
  
  METHODS
  The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.
  
  
  RESULTS
  We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.
  
  
  CONCLUSIONS
  There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Wuhua
authors.initials: W
authors.lastname: Ni
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.forename: Aihua
authors.initials: A
authors.lastname: Wu
authors.forename: Peili
authors.initials: P
authors.lastname: Zhang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yang
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D053713:Azoospermia / Q000235:genetics / Q000473:pathology; D002681:China; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005492:Folic Acid / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D005492:Folic Acid; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C585801:MTR protein, human