title: Obstetric and neonatal outcomes after preterm premature rupture of membranes among women carrying group B streptococcus.
abstract: OBJECTIVE
  To evaluate whether carriers of group B streptococcus (GBS) have adverse obstetric and neonatal outcomes when preterm premature rupture of membranes (PPROM) occurs.
  
  
  METHODS
  In a retrospective study, data were reviewed for women with a singleton pregnancy and PPROM before 34 weeks who attended the Meir Medical Center, Kfar Saba, Israel, between 2005 and 2012. All women received roxithromycin for 1 week, and ampicillin until GBS culture results were available. Ampicillin was continued to 1 week if the GBS culture was positive. The primary study outcome measure was the latency period (time from rupture of membranes to active/induced labor).
  
  
  RESULTS
  Among 116 eligible patients, 21 (18.1%) were GBS carriers and 95 (81.9%) noncarriers. The latency period was 11.2 ± 18.1 days for GBS carriers versus 7.5 ± 9.6 days for noncarriers (P=0.93). However, there was a correlation between the length of ampicillin treatment and the latency period (Spearman correlation coefficient 0.7; P<0.001). There were no differences in early neonatal outcomes.
  
  
  CONCLUSIONS
  GBS carriers with PPROM did not have adverse outcomes. Longer treatment with ampicillin among GBS carriers prolonged the latency period.
authors.affiliation: Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Ganor-Paz
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Kailer
authors.affiliation: Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Gil
authors.initials: G
authors.lastname: Shechter-Maor
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Neonatology Unit, Meir Medical Center, Kfar Saba, Israel.
authors.forename: Rivka
authors.initials: R
authors.lastname: Regev
authors.affiliation: Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Moshe D
authors.initials: MD
authors.lastname: Fejgin
authors.affiliation: Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: shentalt@inter.net.il.
authors.forename: Tal
authors.initials: T
authors.lastname: Biron-Shental
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data*; D002353:Carrier State; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D007743:Labor, Obstetric / Q000187:drug effects*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000517:prevention & control; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D015575:Roxithromycin / Q000008:administration & dosage; D013290:Streptococcal Infections / Q000517:prevention & control / Q000635:transmission; D013292:Streptococcus agalactiae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D015575:Roxithromycin; D000667:Ampicillin
keywords: Adverse obstetric outcomes; Group B streptococcus; Latency period; Preterm premature rupture of membranes