title: Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β.
abstract: Macrophages are important mediators of diseases associated with metabolic inflammation such as obesity and atherosclerosis. In this Stimulus we discuss recent findings showing that heparan sulfate proteoglycans on macrophages serve as an important inflammatory rheostat. This observation has significant implications as the degree of macrophage proteoglycan sulfation can determine and possibly predict disease outcomes of metabolic inflammatory disorders.
authors.affiliation: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
authors.forename: Philip L S M
authors.initials: PL
authors.lastname: Gordts
authors.affiliation: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: jesko@ucsd.edu.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Esko
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D019812:Heparan Sulfate Proteoglycans / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016899:Interferon-beta / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology* / Q000502:physiology; D051379:Mice
chemical_list: D019812:Heparan Sulfate Proteoglycans; D016899:Interferon-beta
keywords: Atherosclerosis; Heparan sulfate proteoglycans; Macrophages; Obesity; Type I Interferon