title: Computational Modelling of Multi-folded Balloon Delivery Systems for Coronary Artery Stenting: Insights into Patient-Specific Stent Malapposition.
abstract: Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or "stenting" is not free of complications. Stent malapposition (SM) is a common feature of "stenting" particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an important risk factor for stent thrombosis and recently it has been associated with longitudinal stent deformation. SM is the result of many factors including reference diameter, vessel tapering, the deployment pressure and the eccentric anatomy of the vessel. For the purpose of the present paper, virtual multi-folded balloon models have been developed for simulated deployment in both constant and varying diameter vessels under uniform pressure. The virtual balloons have been compared to available compliance charts to ensure realistic inflation response at nominal pressures. Thereafter, patient-specific simulations of stenting have been conducted aiming to reduce SM. Different scalar indicators, which allow a more global quantitative judgement of the mechanical performance of each delivery system, have been implemented. The results indicate that at constant pressure, the proposed balloon models can increase the minimum stent lumen area and thereby significantly decrease SM.
authors.affiliation: Computational Engineering & Design Group, Engineering & the Environment, University of Southampton, Boldrewood Campus, Southampton, SO16 7QF, UK.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Ragkousis
authors.forename: Nick
authors.initials: N
authors.lastname: Curzen
authors.forename: Neil W
authors.initials: NW
authors.lastname: Bressloff
mesh_terms: D003198:Computer Simulation; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D057510:Endovascular Procedures / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D015607:Stents