title: Chitosan nanoparticle/PCL nanofiber composite for wound dressing and drug delivery.
abstract: Many investigations of wound dressings equipped with drug delivery systems have recently been conducted. Chitosan is widely used not only as a material for wound dressing by the efficacy of its own, but also as a nanoparticle for drug delivery. In this study, an electrospun polycaprolactone nanofiber composite with chitosan nanoparticles (ChiNP-PCLNF) was fabricated and then evaluated for its drug release and biocompatibility to skin fibroblasts. ChiNP-PCLNF complexes showed no cytotoxicity and nanoparticles adsorbed by van der Waals force were released into aquatic environments and then penetrated into rat primary fibroblasts. Our studies demonstrate the potential for application of ChiNP-PCLNF as a wound dressing system with drug delivery for skin wound healing without side effects.
authors.affiliation: a Department of Biological Engineering , Inha University , Incheon 402-751 , Korea.
authors.forename: Sang-Myung
authors.initials: SM
authors.lastname: Jung
authors.forename: Gwang Heum
authors.initials: GH
authors.lastname: Yoon
authors.forename: Hoo Cheol
authors.initials: HC
authors.lastname: Lee
authors.forename: Hwa Sung
authors.initials: HS
authors.lastname: Shin
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry; D002478:Cells, Cultured; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013718:Tensile Strength; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011134:Polysaccharides; D014867:Water; C016240:polycaprolactone; D048271:Chitosan; C007789:fucoidan
keywords: PCL nanofiber; chitosan nanoparticle; drug delivery system; wound dressing