title: Lipid profile and metabolic syndrome status in patients with oral lichen planus, oral lichenoid reaction and healthy individuals attending a dental college in northern India - a descriptive study.
abstract: BACKGROUND
  Chronic inflammation causes disturbances in the lipid metabolism. When this dyslipidemia becomes prolonged it increases the risk of cardiovascular disease. Recent literature reveals similar dyslipidemia in patients with lichen planus. However, the results were not compared with lichenoid reactions.
  
  
  OBJECTIVE
  The aim of this study was to profile the lipid levels and metabolic syndrome status in patients with oral lichen planus (OLP), oral lichenoid reactions (OLR) and healthy individuals in order to evaluate their respective cardiovascular risk.
  
  
  METHODS
  This case-control descriptive study included 32 adults from the OPD visiting the Department of Oral Medicine, 18 with either oral lichen planus or oral lichenoid reactions and 14 age and sex matched healthy controls. Ethical clearance and informed consent were obtained. Their lipid levels, body mass index and metabolic syndrome status were evaluated. Statistical analyses were performed with the SPSS version 16.0 software.P≥0.05 was considered significant.
  
  
  RESULTS
  The key findings of this study were a) increased levels of S.cholesterol and LDL-C in OLP and OLR patients when compared to normal healthy individuals b) significantly higher S.triglyceride and VLDL in OLP when compared to OLR and c) lower HDL-C levels in OLP when compared to OLR. 2(18%) patients with OLP and 3(50%) with OLR were found to have high BMI suggestive of obesity whereas none of the normal individuals were obese.
  
  
  CONCLUSIONS
  There may be an association between chronic inflammation and dyslipidemia that increases the risk for cardiovascular disease. OLP and OLR patients have increased serum cholesterol and LDL-C when compared to normal adults. Further research on lipid levels in OLR are required to establish the findings of this study.
authors.affiliation: Associate Professor, Department of Oral Medicine and Radiology, ITS-Centre of Dental Sciences and Research , Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India .
authors.forename: Bhuvana
authors.initials: B
authors.lastname: Krishnamoorthy
authors.affiliation: Professor and Head, Department of Oral Medicine and Radiology, ITS-Centre of Dental Sciences and Research , Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India .
authors.forename: Suma
authors.initials: S
authors.lastname: Gn
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, Rajarajeshwari Dental College , Ramohalli Cross, Kumbalogodu, Mysore road, Bangalore, India .
authors.forename: Mamatha
authors.initials: M
authors.lastname: N S
authors.affiliation: Reader, Department of Oral Medicine and Radiology, Rajarajeshwari Dental College , Ramohalli Cross, Kumbalogodu, Mysore road, Bangalore, India .
authors.forename: Sowbhagya
authors.initials: S
authors.lastname: M B
authors.affiliation: Professor, Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Cenntre , Kamalanagar, Hyderabad, India .
authors.forename: Komali
authors.initials: K
authors.lastname: Garlapati
keywords: Dyslipidemia; Lipid profile; Metabolic syndrome status; Oral lichen planus; Oral lichenoid reaction