title: Investigation on immune function and chest drainage in patients with thoracic malignancies using the streptococcal agent Sapylin.
abstract: OBJECTIVE
  To investigate the influence of Sapylin used during the operation on immune function and chest drainage in patients with thoracic malignancies in early postoperative period.
  
  
  METHODS
  Seventy-one patients with thoracic malignancies including lung cancer and esophageal carcinoma who underwent tumor resection were divided into two groups, 36 cases of observation group and 35 cases of control group. In observation group, Sapylin were locally laid in operation field during the operation. The control group was not given Sapylin. Drainage volume of chest cavity after operation, and the levels of CD4, CD8, CD4/CD8 and natural killer (NK) cell were recorded.
  
  
  RESULTS
  The level of CD4+, CD4+/CD8+ and NK cell in observation group were higher than that in control group (P<0.05) wholly in early postoperative period. Drainage volume of chest cavity in observation group was less than that in control group postoperatively, 1160.2±437.2 ml vs. 1363.3±472.9 ml, but the change in two groups had no significance statistically (P=0.064).
  
  
  CONCLUSIONS
  The local application of Sapylin during operation can improve immunity of patients with thoracic malignancies significantly and decrease the drainage volume of chest cavity probably in early postoperative period. So it is worthy of popularizing in clinical practice.
authors.affiliation: Department of Thoracic Surgery, Afflicted Hospital of Medical College, Qingdao University, China.
authors.forename: Kaihua
authors.initials: K
authors.lastname: Tian
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Xuan
mesh_terms: D000368:Aged; D001688:Biological Products / Q000737:chemistry*; D002469:Cell Separation; D015505:Chest Tubes; D004322:Drainage; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008175:Lung Neoplasms / Q000276:immunology* / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011184:Postoperative Period; D013291:Streptococcus / Q000737:chemistry
chemical_list: D001688:Biological Products; C569879:streptococcal preparation 722