title: Exploiting host immunity: the Salmonella paradigm.
abstract: Pathogens have evolved clever strategies to evade and in some cases exploit the attacks of an activated immune system. Salmonella enterica is one such pathogen, exploiting multiple aspects of host defense to promote its replication in the host. Here we review recent findings on the mechanisms by which Salmonella establishes systemic and chronic infection, including strategies involving manipulation of innate immune signaling and inflammatory forms of cell death, as well as immune evasion by establishing residency in M2 macrophages. We also examine recent evidence showing that the oxidative environment and the high levels of antimicrobial proteins produced in response to localized Salmonella gastrointestinal infection enable the pathogen to successfully outcompete the resident gut microbiota.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Behnsen
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
authors.forename: Araceli
authors.initials: A
authors.lastname: Perez-Lopez
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA.
authors.forename: Sean-Paul
authors.initials: SP
authors.lastname: Nuccio
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA; Institute for Immunology, University of California, Irvine School of Medicine, Irvine, CA 92697-4025, USA. Electronic address: manuelar@uci.edu.
authors.forename: Manuela
authors.initials: M
authors.lastname: Raffatellu
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012475:Salmonella / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D051193:Toll-Like Receptors
keywords: Salmonella; immune evasion; immunity; inflammation; mucosal immunity