title: Prevalence of coronary atherosclerosis in an Asian population: findings from coronary computed tomographic angiography.
abstract: We sought to estimate the prevalence of coronary atherosclerosis by coronary computed tomographic angiography (CCTA) and to identify risk factors attributable to the development of coronary atherosclerosis in an asymptomatic Asian population. We analyzed 6,311 consecutive asymptomatic individuals aged 40 and older with no prior history of coronary artery disease (CAD) who voluntarily underwent CCTA evaluation as part of a general health examination. The mean age of study participants was 54.7 ± 7.4 years, and 4,594 (72.8%) were male. After age and gender adjustment using the population census of the National Statistical Office, the prevalence of plaque was 40.5% [95% confidence interval (CI) 38.1-42.9], and significant CAD (diameter stenosis ≥50%) was observed in 9.0% (95% CI 7.7-10.2). Individuals with significant CAD were significantly older than those without (59.2 ± 8.8 vs. 54.0 ± 7.1 years, p < 0.001). Compared with individuals with no cardiovascular risk factors, there was a higher prevalence of significant CAD in individuals with diabetes mellitus [standardized rate ratio (SRR) 2.66; 95% CI 1.93-3.68; p < 0.001], hypertension (SRR 2.24; 95% CI 1.69-2.97; p < 0.001), or hyperlipidemia (SRR 1.65; 95% CI 1.25-2.17; p < 0.001). There was also a greater prevalence of significant CAD in individuals with an intermediate or high Framingham risk score (SRR 5.91; 95% CI 2.34-14.95; p < 0.001) or a high atherosclerotic cardiovascular disease risk score (SRR 8.04; 95% CI 3.04-21.23; p < 0.001). The prevalence of coronary atherosclerosis in this Asian population was not negligible and was associated with known cardiovascular risk factors and high-risk individuals.
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: Gyung-Min
authors.initials: GM
authors.lastname: Park
authors.forename: Sung-Cheol
authors.initials: SC
authors.lastname: Yun
authors.forename: Young-Rak
authors.initials: YR
authors.lastname: Cho
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Gil
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Seon Ha
authors.initials: SH
authors.lastname: Kim
authors.forename: Min-Woo
authors.initials: MW
authors.lastname: Jo
authors.forename: Moo Song
authors.initials: MS
authors.lastname: Lee
authors.forename: Seung-Whan
authors.initials: SW
authors.lastname: Lee
authors.forename: Young-Hak
authors.initials: YH
authors.lastname: Kim
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Yang
authors.forename: Joon-Won
authors.initials: JW
authors.lastname: Kang
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Lim
authors.forename: Beom-Jun
authors.initials: BJ
authors.lastname: Kim
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Koh
authors.forename: Hong-Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Jaewon
authors.initials: J
authors.lastname: Choe
authors.forename: Seong-Wook
authors.initials: SW
authors.lastname: Park
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
mesh_terms: D044466:Asian People; D058070:Asymptomatic Diseases; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000208:ethnology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed