title: Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells.
abstract: This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Bhimashankar
authors.initials: B
authors.lastname: Mitkari
authors.affiliation: Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.
authors.forename: Erja
authors.initials: E
authors.lastname: Kerkelä
authors.affiliation: Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Nystedt
authors.affiliation: Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Korhonen
authors.affiliation: Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Jolkkonen
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000378:metabolism / Q000473:pathology*
chemical_list: D016229:Amyloid beta-Peptides; D002118:Calcium