title: In vitro antimicrobial activity of solution blow spun poly(lactic acid)/polyvinylpyrrolidone nanofibers loaded with Copaiba (Copaifera sp.) oil.
abstract: In this study poly(lactic acid) (PLA) and polyvinylpyrrolidone (PVP) micro- and nanofiber mats loaded with Copaiba (Copaifera sp.) oil were produced by solution blow spinning (SBS). The Copaiba (Copaifera sp.) oil was characterized by gas chromatography (GC). Neat PLA and four PLA/PVP blends containing 20% (wt.%) oil were spun and characterized by scanning electron microscopy (SEM) and by studying the surface contact angle, in vitro release rate, and antimicrobial activity. All compositions evaluated were able to produce continuous and smooth fibers by SBS. The addition of PVP increased fiber diameter, and decreased the surface contact angle. GC analysis demonstrated that the main component of the Copaiba oil was β-caryophyllene, a known antimicrobial agent. In vitro release tests of Copaiba oil volatiles demonstrated a higher release rate in fibers containing PVP. Fiber mats made from blends containing higher amounts of PVP had greater antimicrobial action against Staphylococcus aureus. The results confirm the potential of the fiber mats for use in controlled drug release and could lead to promising applications in the biomedical field.
authors.affiliation: Departamento de Engenharia de Materiais (DEMAT), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil; Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: Roberta F
authors.initials: RF
authors.lastname: Bonan
authors.affiliation: Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: Paulo R F
authors.initials: PR
authors.lastname: Bonan
authors.affiliation: Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: André U D
authors.initials: AU
authors.lastname: Batista
authors.affiliation: Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: Fábio C
authors.initials: FC
authors.lastname: Sampaio
authors.affiliation: Centro de Ciências da Saúde (CCS), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: Allan J R
authors.initials: AJ
authors.lastname: Albuquerque
authors.affiliation: Embrapa Recursos Genéticos e Biotecnologia, Parque Estação Ecológica, W/5 Norte (Final) Cenargen (Laboratório de Semioquímicos) ASA NORTE, 70770900 Brasília, DF, Brazil.
authors.forename: Maria C B
authors.initials: MC
authors.lastname: Moraes
authors.affiliation: Laboratório Nacional de Nanotecnologia para o Agronegócio (LNNA), Embrapa Instrumentação Agropecuária (CNPDIA), Rua XV de Novembro, 1452, Centro, 13.560, 970 São Carlos, SP, Brazil.
authors.forename: Luiz H C
authors.initials: LH
authors.lastname: Mattoso
authors.affiliation: United States Department of Agriculture (USDA), Western Regional Research Center (WRRC), Bioproduct Chemistry and Engineering (BCE), Albany, CA 94710, USA.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Glenn
authors.affiliation: Departamento de Engenharia de Materiais (DEMAT), Universidade Federal da Paraíba (UFPB), Cidade Universitária, 58.051-900 João Pessoa, PB, Brazil.
authors.forename: Eliton S
authors.initials: ES
authors.lastname: Medeiros
authors.affiliation: Departamento de Engenharia, Universidade Federal de Lavras, Campus Universitário, 37200-000 Lavras, MG, P.O. Box: 3037, Brazil. Electronic address: juliano.materiais@gmail.com.
authors.forename: Juliano E
authors.initials: JE
authors.lastname: Oliveira
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D011205:Povidone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D010938:Plant Oils; D011091:Polyesters; D011108:Polymers; C077842:polyvinylpolypyrrolidone; D019344:Lactic Acid; C033616:poly(lactide); D011205:Povidone
keywords: (Copaifera sp.) oil; Antimicrobial activity; Drug delivery system; Nanofibers; Solution blow spinning