title: [Detection rate analysis on neurological sign of workers exposed to different concentrations of carbon disulfide].
abstract: OBJECTIVE
  To study the effects of exposed to different concentrations of carbon disulfide on neurological signs of workers.
  
  
  METHODS
  Collection the information of concentration of carbon disulfide in the workplace or workers individuals exposed of a chemical fiber industry from 2004 to 2011, a total of 3 537 workers exposed to carbon disulfide were detected muscle strength and muscle tone, knee reflex, Achilles tendon reflex, trembling limbs, sensory function, and three chatter. Chi-square test was used for statistical analysis on abnormal neurological signs of workers.
  
  
  RESULTS
  Eight hours time-weighted average concentration range of workers exposed to carbon disulfide in this chemical fiber industry was 0.2-41.0 mg/m(3), geometric mean was 2.38 mg/m(3). Concentration of carbon disulfide exposure of 1 771 workers was from 0.2 to 2.5 mg/m3( ≤ 2.5 mg/m(3)), 642 workers was 2.6-4.8 mg/m(3) (< 5.0 mg/m(3)), other 1 051 workers was from 5.1 to 41.0 mg/m(3) ( > 5.0 mg/m(3)) in all subjects. The different detection rates of knee reflex were 3.0% (31/1 045), 3.7% (21/574), 4.8% (16/331), 3.3% (10/305), 5.9% (11/187), 6.7% (68/1 022), the different detection rates of Achilles tendon reflex were 2.2% (23/1 045), 3.7% (21/574), 2.7% (9/331), 2.3% (7/305), 2.1% (4/187), 5.6% (57/1 022), the different detection rates of sensory dysfunction were 0.4% (4/1 045), 0.5% (3/574), 0.6% (2/331), 0.0% (0/305), 2.1% (4/187), 1.7% (17/1 022) in different cumulative amount of contact groups ( ≤ 10.0, 10.1-20.0, 20.1-30.0, 30.1-40.0, 40.1-50.0, >50.0 mg/m(3) per year), and the differences were statistically significant (χ(2) = 19.53, 21.27 and 15.89, all P values were <0.01) . Stratified according to age and gender, in addition to the ≤ 25 years group the difference of detection rate analysis on Achilles tendon reflex was statistically significant in the different concentration group (the ratio of on Achilles tendon reflex in the different groups of concentration of carbon disulfide exposure of 2.5, 2.6-5.0, ≥ 5.0 mg/m(3) were 0.4% (2/511), 1.0% (1/98), 2.1% (7/327), χ(2) = 5.59, P = 0.045) , the difference of detection rate analysis on neurological sign was not statistically significant in the different concentration group on the rest of the age and gender groups (P > 0.05).
  
  
  CONCLUSIONS
  Within the concentration range of the object of study contact actual, different concentrations of carbon disulfide in addition to individual neurological signs of individual ages influential, it has no significant effect on the various signs of nervous system of workers of most age and gender groups, expect the age below the 25 years old group.
authors.affiliation: The Occupational Disease Prevention and Control Institute of Henan Province, Zhengzhou 450052, China.
authors.forename: Kuirong
authors.initials: K
authors.lastname: Li
authors.forename: Wenhui
authors.initials: W
authors.lastname: Zhou
authors.forename: Guizhen
authors.initials: G
authors.lastname: Gu
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhou
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Email: yu-shanfa@163.com.
authors.forename: Shanfa
authors.initials: S
authors.lastname: Yu
mesh_terms: D000328:Adult; D000367:Age Factors; D002246:Carbon Disulfide / Q000009:adverse effects*; D002617:Chemical Industry; D002681:China; D006801:Humans; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D017132:Workplace
chemical_list: D002246:Carbon Disulfide