title: State machine modeling of MAPK signaling pathways.
abstract: Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and carcinogenesis. A finite state machine model of MAPK cellular signaling is explored as an alternative to differential equations-based models of kinetics. The proposed approach is applied to the Ras-Extracellular signal-regulated kinase (Ras-ERK) pathway which includes the frequently mutated Ras and RAF proteins in many types of carcinomas.
authors.forename: Youcef
authors.initials: Y
authors.lastname: Derbal
mesh_terms: D000465:Algorithms; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology; D013997:Time Factors; D018631:ras Proteins / Q000378:metabolism
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases; D018631:ras Proteins