title: Chest HRCT findings in acute transformation of adult T-cell lymphoma/leukemia.
abstract: OBJECTIVE
  To assess chest high-resolution computed tomography (HRCT) findings in patients with acute transformation of adult T cell leukaemia/lymphoma (ATLL).
  
  
  METHODS
  We retrospectively identified 72 consecutive patients at our institution with ATLL between October 2000 and March 2014. The cases included acute type (n = 20), lymphoma type (n = 21), smouldering type (n = 24) and chronic type (n = 7). Sixteen (7 men, 9 women; aged 36-85 years, mean 63.3 years) of 31 patients (24 with smouldering and seven with chronic type; 51.6 %) developed acute transformation of ATLL, and had undergone chest HRCT examinations. Parenchymal abnormalities, enlarged lymph nodes, pericardial effusion, pleural effusion and skin lesions were evaluated on HRCT.
  
  
  RESULTS
  Chest HRCT of 15 of the 16 patients showed abnormal findings, including ground-glass opacity (GGO) (n = 8), consolidation (n = 5), interlobular septal thickening (n = 5) and nodules (n = 5). Pleural effusion was found in five patients, lymph node enlargement in 10 patients and multiple skin thickening in two patients.
  
  
  CONCLUSIONS
  Almost all patients with acute transformation of ATLL had abnormal findings on chest HRCT, which consisted mainly of lymph node enlargement, GGO, interlobular septal thickening, nodules and bilateral pleural effusions.
  
  
  CONCLUSIONS
  • The recognition of CT findings of acute transformation is important • Almost all patients with acute transformation have abnormal findings on HRCT • Characteristic CT features are present in acute transformation of indolent ATLL.
authors.affiliation: Department of Radiology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan, fumitook@oita-u.ac.jp.
authors.forename: Fumito
authors.initials: F
authors.lastname: Okada
authors.forename: Haruka
authors.initials: H
authors.lastname: Sato
authors.forename: Ahmad Khalid
authors.initials: AK
authors.lastname: Omeri
authors.forename: Asami
authors.initials: A
authors.lastname: Ono
authors.forename: Kouhei
authors.initials: K
authors.lastname: Tokuyama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ando
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohno
authors.forename: Kuniko
authors.initials: K
authors.lastname: Takano
authors.forename: Hiromu
authors.initials: H
authors.lastname: Mori
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000000981:diagnostic imaging*; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000150:complications / Q000000981:diagnostic imaging; D010996:Pleural Effusion / Q000150:complications / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D054088:Ventricular Septum / Q000000981:diagnostic imaging