title: Transition-metal-free synthesis of phenanthridinones from biaryl-2-oxamic acid under radical conditions.
abstract: Na2S2O8-promoted decarboxylative cyclization of biaryl-2-oxamic acid for phenanthridinones has been developed. This work illustrates the first example of intramolecular decarboxylative amidation of unactivated arene under transition-metal-free conditions. Additionally, this approach provides an efficient and economical method to access biologically interesting phenanthridinones, an important structure motif in many natural products.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yuan
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Junwei
authors.initials: J
authors.lastname: Wang
authors.forename: Shenjie
authors.initials: S
authors.lastname: Chen
authors.forename: Kongchao
authors.initials: K
authors.lastname: Wang
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Xue
authors.forename: Guangmin
authors.initials: G
authors.lastname: Yao
authors.forename: Zengwei
authors.initials: Z
authors.lastname: Luo
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010072:Oxamic Acid / Q000737:chemistry*; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D001688:Biological Products; D010617:Phenanthridines; D028561:Transition Elements; D010072:Oxamic Acid