title: Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition.
abstract: Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
authors.affiliation: College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791.
authors.forename: Ok-Nam
authors.initials: ON
authors.lastname: Bae
authors.affiliation: Collge of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742.
authors.forename: Minsoo
authors.initials: M
authors.lastname: Noh
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Chun
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Republic of Korea.
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
keywords: Biomarker; Dermal toxicity; Keratinocytic damage; Vascular endothelial growth factor (VEGF)