title: The RUNX family: developmental regulators in cancer.
abstract: RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a prominent and, at times, paradoxical role in cancer pathogenesis. The contextual cues that direct RUNX function represent a fast-growing field in cancer research and could provide insights that are applicable to early cancer detection and treatment. This Review describes how RUNX proteins communicate with key signalling pathways during the multistep progression to malignancy; in particular, we highlight the emerging partnership of RUNX with p53 in cancer suppression.
authors.affiliation: 1] Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive #12-01, 117599, Singapore. [2].
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ito
authors.affiliation: 1] Department of Biochemistry, School of Medicine, and Institute for Tumour Research, Chungbuk National University, Cheongju, 361763, South Korea. [2].
authors.forename: Suk-Chul
authors.initials: SC
authors.lastname: Bae
authors.affiliation: 1] Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive #12-01, 117599, Singapore. [2].
authors.forename: Linda Shyue Huey
authors.initials: LS
authors.lastname: Chuang
mesh_terms: D020727:ADP-Ribosylation Factors / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D050657:Core Binding Factor alpha Subunits / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009369:Neoplasms / Q000235:genetics*; D010766:Phosphorylation; D015398:Signal Transduction / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D050657:Core Binding Factor alpha Subunits; D016159:Tumor Suppressor Protein p53; D018844:Cyclin-Dependent Kinases; D020727:ADP-Ribosylation Factors