title: From the RNA world to the RNA/protein world: contribution of some riboswitch-binding species?
abstract: Some amino acids and their formal derivatives, currently riboswitch-binding species, could have interacted with polyribonucletides in prebiotic environments, leading to the peptide formation. If the resulting compounds had led to a sustainable polymerization of amino acids and the new structures had catalytic activity, such would have been an important contribution to the transition from the RNA world to the RNA/Protein world.
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal. Electronic address: pcd1950@tecnico.ulisboa.pt.
authors.forename: José A L
authors.initials: JA
authors.lastname: da Silva
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D008024:Ligands; D010455:Peptides / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D058928:Riboswitch
chemical_list: D000596:Amino Acids; D008024:Ligands; D010455:Peptides; D011506:Proteins; D058928:Riboswitch; D012313:RNA; D000604:Amino Acyl-tRNA Synthetases
keywords: Early aminoacylation; Origin of life; Ribonucleosyl peptides; S-adenosyl-L-methionine; l-lysine