title: Quetiapine-induced myocarditis presenting as acute STEMI.
abstract: An 18-year-old man diagnosed with attention-deficit hyperactivity disorder was recently started on quetiapine in addition to regular methylphenidate, which he had been taking for a number of years. He presented with chest pain and inferolateral ST elevation, and underwent urgent coronary angiography, which showed normal coronary arteries. The initial troponin level was raised and an inpatient echocardiogram showed mild left ventricular systolic dysfunction with no evidence of regional wall motion abnormality. Cardiac MRI showed subepicardial late gadolinium enhancement, which was suggestive of myocarditis. Quetiapine and methylphenidate were discontinued and the patient was discharged home after 1 week. He was followed up within 8 weeks with complete recovery and no symptoms.
authors.affiliation: Department of Cardiology, Royal Wolverhampton Hospital, Wolverhampton, UK.
authors.forename: Nancy
authors.initials: N
authors.lastname: Wassef
authors.affiliation: Department of Pharmacy, Royal Wolverhampton Hospital, Wolverhampton, UK.
authors.forename: Nazish
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Cardiology, Royal Wolverhampton Hospital, Wolverhampton, UK.
authors.forename: Shahzad
authors.initials: S
authors.lastname: Munir
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D001714:Bipolar Disorder / Q000188:drug therapy; D002637:Chest Pain / Q000139:chemically induced*; D003937:Diagnosis, Differential; D003987:Dibenzothiazepines / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000175:diagnosis*; D009205:Myocarditis / Q000139:chemically induced* / Q000175:diagnosis*; D000069348:Quetiapine Fumarate; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate; D000069348:Quetiapine Fumarate