title: Acute Kidney Injury in Elderly Patients With Non-ST Elevation Acute Coronary Syndrome: Insights From the Italian Elderly: ACS Study.
abstract: We examined the incidence and predictors of acute kidney injury (AKI) in elderly patients (≥75 years) enrolled in the prospective Italian Elderly acute coronary syndrome (ACS) study and explored the impact of AKI on clinical outcome. Acute kidney injury, defined according to the Acute Kidney Injury Network criteria, occurred in 128 (21%) of 615 patients. Patients submitted to coronary angiographic procedures did not present higher rate of AKI. The only baseline variables independently associated with AKI development were creatinine clearance (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.97-0.99) and left ventricular ejection fraction (OR: 0.98; 95% CI: 0.96-0.99). Adverse clinical events were significantly higher in patients who developed AKI. After multivariable adjustment, AKI (hazard ratio: 2.73; 95% CI: 1.87-4.0) was an independent predictor of all-cause mortality within 1 year.
authors.affiliation: Cardiology Division, Santo Stefano Hospital, Prato, Italy anna.toso@libero.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Toso
authors.affiliation: IRCCS Fondazione Policlinico, San Matteo, Pavia, Italy.
authors.forename: Stefano De
authors.initials: SD
authors.lastname: Servi
authors.affiliation: Cardiology Division, Santo Stefano Hospital, Prato, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Leoncini
authors.affiliation: Azienda Ospedaliera Ospedale Niguarda Cà Granda, Milano, Italy.
authors.forename: Nuccia
authors.initials: N
authors.lastname: Morici
authors.affiliation: Ospedale S. Maria delle Grazie, Pozzuoli, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Murena
authors.affiliation: INRCA, Ancona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Antonicelli
authors.affiliation: Azienda Ospedaliera Ospedale Santa Maria della Misericordia, Perugia, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cavallini
authors.affiliation: Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
authors.forename: Anna Sonia
authors.initials: AS
authors.lastname: Petronio
authors.affiliation: Ospedale Santa Croce e Carle, Cuneo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Steffenino
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Fisciano, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Piscione
authors.affiliation: Cardiology Division, Santo Stefano Hospital, Prato, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bellandi
authors.affiliation: Cardiology Division, A. Manzoni Hospital, Lecco, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Savonitto
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000401:mortality; D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: acute coronary syndrome; acute kidney injury; elderly