title: Long-term stabilization by radiosurgery of a secondary focal anaplastic transformation in a surgically treated WHO grade II oligodendroglioma. A case report.
abstract: We report on a young woman with a left temporal diffuse low-grade glioma treated initially by a subtotal resection. A focal anaplastic area appeared 5years later and was treated by radiosurgery. A long-time stabilization was therefore obtained and lasted even after pregnancy, which is a known factor of faster tumour progression. This report shows that radiosurgery could be an option in the multimodal treatment of a selected group of patients with focal malignant transformation of diffuse low-grade glioma. It could permit long-term stabilization of the tumour without any other adjuvant treatment and without compromising the quality of life.
authors.affiliation: Service de Neurochirurgie, HIA Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France. Electronic address: yn.yordanova@gmail.com.
authors.forename: Y N
authors.initials: YN
authors.lastname: Yordanova
authors.affiliation: Service de Neurochirurgie, Hôpital Gui-de-Chauliac, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Rodriguez-Arribas
authors.affiliation: Service de Neurochirurgie, Hôpital Gui-de-Chauliac, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France; Équipe 4 « Plasticité du Système Nerveux Central, Cellules Souches et Tumeurs Gliales », INSERM 1051, Institut de Neurosciences de Montpellier, Hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34091 Montpellier Cedex 5, France.
authors.forename: H
authors.initials: H
authors.lastname: Duffau
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants; D001932:Brain Neoplasms / Q000601:surgery*; D002277:Carcinoma / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009837:Oligodendroglioma / Q000601:surgery*; D011247:Pregnancy; D016634:Radiosurgery / Q000379:methods*; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: Anaplastic oligodendroglioma; Grossesse; Long-term survival; Oligodendrogliome anaplasique; Pregnancy; Radiochirurgie; Radiosurgery; Survie à long terme