title: Serine/Threonine phosphatases: classification, roles and pharmacological regulation.
abstract: Phosphatases are important enzymes in a variety of biochemical pathways in different cells which they catalyze opposing reactions of phosphorylation and dephosphorylation, which may modulate the function of crucial signaling proteins in different cells. This is an important mechanism in the regulation of intracellular signal transduction pathways in many cells. Phosphatases play a key role in regulating signal transduction. It is known that phosphatases are specific for cleavage of either serine-threonine or tyrosine phosphate groups. To date, numerous compounds have been identified. This paper reviews the classification, roles and pharmacological of protein serine/threonine phosphates.
authors.affiliation: Department of Human Vaccine, Razi-Karaj Institute, Karaj, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Bastan
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Eskandari
authors.affiliation: Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: A M
authors.initials: AM
authors.lastname: Sabzghabaee
authors.affiliation: Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Manian
mesh_terms: D000818:Animals; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000145:classification / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology
chemical_list: D010749:Phosphoprotein Phosphatases