title: Cadmium transporters in the kidney and cadmium-induced nephrotoxicity.
abstract: Among the organs in which the environmental pollutant cadmium causes toxicity, the kidney has gained the most attention in recent years. Numerous studies have sought to unravel the exact pathways by which cadmium enters the renal epithelial cells and the mechanisms by which it causes toxicity in the kidney. The purpose of this review is to present the progress made on the mechanisms of cadmium transport in the kidney and the role of transporter proteins in cadmium-induced nephrotoxicity.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA. hong.yang@umaryland.edu.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA. yshu@rx.umaryland.edu.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shu
mesh_terms: D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity; D015220:Calcium Channels / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D002104:Cadmium; D015220:Calcium Channels; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D008668:Metallothionein; D027701:Organic Cation Transport Proteins; D000099236:Solute Carrier Family 11, Member 2; C017800:zinc-binding protein