title: Relationship between levels of brain-derived neurotrophic factor and metabolic parameters in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients.
  
  
  RESULTS
  The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 ± 107.32 pg/mL versus 130.84 ± 59.81 pg/mL; P < 0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.28; P < 0.05), the triglyceride level (r = 0.265; P < 0.05), and white blood cell (WBC) count (r = 0.35; P < 0.001). In logistic regression analysis, age (P < 0.05), body mass index (BMI) (P < 0.05), C-reactive protein (CRP) (P < 0.05), and BDNF (P < 0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137.
  
  
  CONCLUSIONS
  The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.
authors.affiliation: Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Boyuk
authors.affiliation: Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
authors.forename: Serife
authors.initials: S
authors.lastname: Degirmencioglu
authors.affiliation: Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
authors.forename: Hande
authors.initials: H
authors.lastname: Atalay
authors.affiliation: Department of Biochemistry, Namik Kemal University, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.affiliation: Department of Biochemistry, Namik Kemal University, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Acar
authors.affiliation: Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Celebi
authors.affiliation: Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Siraselviler Caddesi No. 112, 34433 Istanbul, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Ekizoglu
authors.affiliation: Department of Diabetic Patient Education and Care Policlinic, Gaziosmanpasa Taksim Education and Research Hospital, Turkey.
authors.forename: Caglar
authors.initials: C
authors.lastname: Simsek
mesh_terms: D000367:Age Factors; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D018836:Inflammation Mediators; D007328:Insulin; D014280:Triglycerides; C579455:BDNF protein, human; D002097:C-Reactive Protein