title: Dose-responses of zinc-methionine supplements on growth, blood metabolites and gastrointestinal development in sheep.
abstract: The effects of zinc-methionine (Zn-Met) supplementation on growth, blood metabolites and gastrointestinal development were investigated in two experiments with sheep. The objective of Experiment 1 was to determine the effects of Zn-Met supplementation on hormones and metabolites involved in growth and energy balance regulation, while Experiment 2 aimed to determine the effects of Zn-Met on feed intake, body weight, gastrointestinal development and liver glycogen concentration in lamb. The animals were assigned to groups with different concentrations of dietary Zn-Met (0, 0.4, 0.8 and 1.2 g/day) in both experiments. In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH). No differences were observed in blood cortisol, insulin and glucose concentrations among the treatments. In Experiment 2, addition of Zn-Met to the diets did not lead to changes in the body weights of the lambs. Both average daily gain and dry matter intake (DMI) increased linearly with increasing concentrations of dietary Zn-Met. Lambs receiving Zn-Met showed higher liver glycogen concentrations than the control. While significant increases were observed in the villus height and crypt depth in the duodenum and jejunum as a result of Zn-Met supplementation, no change was detected in blood glucose concentrations (p > 0.05). Our findings suggest that dietary Zn-Met may improve growth, energy balance and gastrointestinal development in sheep.
authors.affiliation: Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Jafarpour
authors.affiliation: Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khorvash
authors.affiliation: Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.
authors.forename: H R
authors.initials: HR
authors.lastname: Rahmani
authors.affiliation: Department of Production Animal Health, Faculty of Veterinary Medicine, Gastrointestinal Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Pezeshki
authors.affiliation: Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Hosseini Ghaffari
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000254:growth & development*; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep / Q000097:blood / Q000254:growth & development*; D015430:Weight Gain
chemical_list: D009942:Organometallic Compounds; C074508:zinc methionine; D008715:Methionine
keywords: growth; gut morphology; sheep; zinc-methionine