title: Bayesian model selection for multiple QTLs mapping combining linkage disequilibrium and linkage.
abstract: Linkage disequilibrium (LD) mapping is able to localize quantitative trait loci (QTL) within a rather small region (e.g. 2 cM), which is much narrower than linkage analysis (LA, usually 20 cM). The multilocus LD method utilizes haplotype information around putative mutation and takes historical recombination events into account, and thus provides a powerful method for further fine mapping. However, sometimes there are more than one QTLs in the region being studied. In this study, the Bayesian model selection implemented via the Markov chain Monte Carlo (MCMC) method is developed for fine mapping of multiple QTLs using haplotype information in a small region. The method combines LD as well as linkage information. A series of simulation experiments were conducted to investigate the behavior of the method. The results showed that this new multiple QTLs method was more efficient in separating closely linked QTLs than single-marker association studies.
authors.affiliation: Life Science College, Heilongjiang Bayi Agricultural University,Daqing,163319,People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases,Affiliated Hospital of Guangdong Medical College,Zhanjiang,524000,People's Republic of China.
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
authors.affiliation: Research Centre for Fisheries Resource and Environment,Chinese Academy of Fishery Sciences,Beijing,100141,People's Republic of China.
authors.forename: Runqing
authors.initials: R
authors.lastname: Yang
authors.affiliation: Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases,Affiliated Hospital of Guangdong Medical College,Zhanjiang,524000,People's Republic of China.
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
authors.affiliation: Life Science College, Heilongjiang Bayi Agricultural University,Daqing,163319,People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
mesh_terms: D001499:Bayes Theorem; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D006239:Haplotypes / Q000235:genetics; D016013:Likelihood Functions; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D040641:Quantitative Trait Loci / Q000235:genetics*