title: Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: role of adiponectin and TNF-α.
abstract: Mangiferin, present in Mangifera indica bark, was reported to produce hypoglycemic and antidiabetic activity in an animal model of genetic type 2 diabetes and in streptozotocin diabetic rats. Its effect on diabetic insulin-resistant animals has not been investigated. The current work aimed to explore the effect of mangiferin on diabetic insulin-resistant rat model. Diabetes was induced by high-fat/high fructose diet for eight weeks followed by a subdiabetogenic dose of streptozotocin (HFD-Fr-STZ). Rats were treated with mangiferin (20 mg/kg i.p.) for 28 days starting one week after STZ and its effects were compared to the standard insulin sensitizer, rosiglitazone. HFD-Fr-STZ, induced obesity, hyperglycemia and insulin resistance accompanied by depletion in liver glycogen and dyslipidemia. Moreover, there was an elevation in serum TNF-α and a reduction in adiponectin. Mangiferin ameliorated the consequences of HFD-Fr-STZ and its actions were comparable to the effects of the standard insulin sensitizer, rosiglitazone. The results obtained in this study provide evidence that mangiferin is a possible beneficial natural compound for type 2 diabetes and metabolic disorders associated with the metabolic syndrome. This effect is mediated through improving insulin sensitivity, modulating lipid profile and reverting adipokine levels to normal.
authors.affiliation: Faculty of Pharmacy, Department of Pharmacology and Toxicology, Cairo University, Kasr El-Aini, Cairo, Egypt.
authors.forename: Samira
authors.initials: S
authors.lastname: Saleh
authors.affiliation: Faculty of Pharmacy, Department of Pharmacology and Toxicology, Zagazig University, Zagazig, Egypt.
authors.forename: Nabila
authors.initials: N
authors.lastname: El-Maraghy
authors.affiliation: Center Axis, Faculty of Pharmacy, October 6 University, 6 October City, Egypt.
authors.forename: Enji
authors.initials: E
authors.lastname: Reda
authors.affiliation: Faculty of Pharmacy, Department of Pharmacology and Toxicology, Zagazig University, Zagazig, Egypt.
authors.forename: Waleed
authors.initials: W
authors.lastname: Barakat
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D050171:Dyslipidemias / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051381:Rats; D000077154:Rosiglitazone; D013311:Streptozocin; D045162:Thiazolidinediones / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: D052242:Adiponectin; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D014409:Tumor Necrosis Factor-alpha; D044004:Xanthones; D000077154:Rosiglitazone; C013592:mangiferin; D013311:Streptozocin