title: A novel multi-parametric algorithm for faint prediction integrating indices of cardiac inotropy and vascular tone.
abstract: Neurally medicated syncope (NMS) patients suffer from sudden loss of consciousness, which is associated with a high rate of falls and hospitalization. NMS negatively impacts a subject's quality of life and is a growing cost issue for the healthcare systems in particular since mainly elderly are at risk of NMS in our aging societies. In the present paper we present an algorithm for prediction of NMS, which is based on the analysis of the electrocardiogram (ECG) and photoplethysmogram (PPG) signals. Several parameters extracted from ECG and PPG, which have been associated in previous works with reflectory mechanisms underlying NMS, were combined in a single algorithm to detect impending syncope. The proposed algorithm was validated in 43 subjects using a 3-way data split scheme and achieved the following performance: sensitivity (SE) - 100%; specificity (SP) - 92%; positive predictive value (PPV) - 85%; false positive rate per hour (FPRh) - 0.146h(-1) and; average prediction time (aPTime) - 217.58s.
authors.forename: R
authors.initials: R
authors.lastname: Couceiro
authors.forename: P
authors.initials: P
authors.lastname: Carvalho
authors.forename: R P
authors.initials: RP
authors.lastname: Paiva
authors.forename: J
authors.initials: J
authors.lastname: Muehlsteff
authors.forename: J
authors.initials: J
authors.lastname: Henriques
authors.forename: C
authors.initials: C
authors.lastname: Eickholt
authors.forename: C
authors.initials: C
authors.lastname: Brinkmeyer
authors.forename: M
authors.initials: M
authors.lastname: Kelm
authors.forename: C
authors.initials: C
authors.lastname: Meyer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001794:Blood Pressure; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D017156:Photoplethysmography; D012680:Sensitivity and Specificity; D016683:Supine Position; D013575:Syncope / Q000175:diagnosis* / Q000188:drug therapy; D018667:Tilt-Table Test; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin