title: Immunomodulatory role of microRNAs transferred by extracellular vesicles.
abstract: The immune system is composed of different cell types localised throughout the organism to sense and respond to pathological situations while maintaining homeostasis under physiological conditions. Intercellular communication between immune cells is essential to coordinate an effective immune response and involves both cell contact dependent and independent processes that ensure the transfer of information between bystander and distant cells. There is a rapidly growing body of evidence on the pivotal role of extracellular vesicles (EVs) in cell communication and these structures are emerging as important mediators for immune modulation upon delivery of their molecular cargo. In the last decade, EVs have been shown to be efficient carriers of genetic information, including microRNAs (miRNAs), that can be transferred between cells and regulate gene expression and function on the recipient cell. Here, we review the current knowledge of intercellular functional transfer of EV-delivered miRNAs and their putative role in immune regulation.
authors.affiliation: Immunology Service, Hospital de la Princesa, Madrid, Spain; Department of Vascular Biology and Inflammation, National Centre for Cardiovascular Research (CNIC), Madrid, Spain.
authors.forename: Lola
authors.initials: L
authors.lastname: Fernández-Messina
authors.forename: Cristina
authors.initials: C
authors.lastname: Gutiérrez-Vázquez
authors.forename: Eva
authors.initials: E
authors.lastname: Rivas-García
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Madrid
authors.forename: Hortensia
authors.initials: H
authors.lastname: de la Fuente
mesh_terms: D000818:Animals; D002450:Cell Communication; D000067128:Extracellular Vesicles / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology*; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*
chemical_list: D035683:MicroRNAs
keywords: Exosomes; Extracellular vesicles (EVs); Immune modulation; Intercellular communication; MicroRNA (miRNA)