title: Isolation of a novel antibacterial phenyl thioketone from the seagrass, Cymodocea serrulata.
abstract: A total of 40 extract types of varying polarities from commonly occurring seagrasses were tested for their antibacterial efficiency against 14 clinically isolated human pathogens using agar well diffusion technique. The extracts from acetone of Cymodocea serrulata expressed moderate broad span of activity against a range of gram-positive and gram-negative isolates that were at least resistant to five of the commercially available antibiotics at a minimal concentration of 10 µg. The active extracts of C. serrulata that showed maximal inhibitions were purified using column chromatography that afforded six compounds (a-f). Compound f elicited pronounced inhibitions against Escherichia coli with minimal inhibitory concentration values of 1-3 µg concentration using micro-dilution method. The active compound was identified as phenyl thioketone using various spectral analyses. This is the first investigation that reveals thioketone functionality from this seagrass species possessing antibacterial actions. This study indicates that there are thiocarbonyl groups from marine floral sources too, which could be possibly used for therapeutic purposes.
authors.affiliation: Department of Biotechnology, Sri Ramachandra University, Porur, Chennai, 600 016, Tamil Nadu, India.
authors.forename: K Mary Elizabeth
authors.initials: KM
authors.lastname: Gnanambal
authors.forename: Jamila
authors.initials: J
authors.lastname: Patterson
authors.forename: Edward J K
authors.initials: EJ
authors.lastname: Patterson
mesh_terms: D035961:Alismatales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D007659:Ketones / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000302:isolation & purification / Q000494:pharmacology; D013871:Thiones / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007659:Ketones; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D013871:Thiones; C000601058:phenyl thioketone
keywords: Cymodocea serrulata; antibacterial; phenyl thioketone; seagrass