title: Comaneci neck bridging device for the treatment of cerebral aneurysms.
abstract: OBJECTIVE
  Adjunctive devices are commonly employed in the treatment of wide necked cerebral aneurysms. Balloon remodeling and permanent stent implantation may lead to thromboembolic complications or the need for antiplatelet use. A temporary stent that does not lead to complete flow arrest may be beneficial.
  
  
  METHODS
  We studied 20 New Zealand white rabbits in whom aneurysms were created using elastase and ligation of the right common carotid artery. The aneurysms were then embolized with bare platinum coils along with adjunctive treatment using the Comaneci device or the Hyperglide balloon. Assessments were made for endothelial injury using scanning electron microscopy (SEM) and light microscopy.
  
  
  RESULTS
  20 rabbits of mean±SD weight 3.1±0.2 kg were studied. Twelve rabbits were treated with the Comaneci device and eight with the Hyperglide balloon. There were no substantial differences on SEM or light microscopy in the subacute and chronic phase to suggest the Comaneci device caused endothelial injury.
  
  
  CONCLUSIONS
  The Comaneci device is a new adjuvant treatment for bridging of wide necked aneurysms with the advantage of averting flow arrest during deployment. There does not appear to be any evidence of significant endothelial damage during deployment in preclinical studies.
authors.affiliation: Wellstar Medical Group Neurosurgery, Wellstar Neurosciences Network, Marietta, Georgia, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Cardiology, CVPath Institute, Gaithersburg, Maryland, USA.
authors.forename: Frank D
authors.initials: FD
authors.lastname: Kolodgie
authors.affiliation: Department of Cardiology, CVPath Institute, Gaithersburg, Maryland, USA.
authors.forename: Renu
authors.initials: R
authors.lastname: Virmani
authors.affiliation: Rapid Medical, Yokneam, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Eckhouse
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D004867:Equipment Design / Q000295:instrumentation; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery*; D011817:Rabbits; D015607:Stents; D016896:Treatment Outcome
keywords: Aneurysm; Device; Stent