title: Chondroitin sulphate-guided construction of polypyrrole nanoarchitectures.
abstract: Nanospheres, nanocones, and nanowires are three typical polypyrrole (PPy) nanoarchitectures and electrochemically polymerized with the dope of chondroitin sulphate (CS) in this study. CS, a functional biomacromolecule, guides the formation of PPy nanoarchitectures as the dopant and morphology-directing agent. Combined with our previous reported other PPy nanoarchitectures (such as nanotube arrays and nanowires), this work further proposed the novel mechanism of the construction of PPy/CS nanoarchitectures with the synergistic effect of CS molecular chains structure and the steric hindrance. Compared to the undoped PPy, MC3T3-E1 cells with PPy/CS nanoarchitectures possessed stronger proliferation and osteogenic differentiation capability. This suggests that PPy/CS nanoarchitectures have appropriate biocompatibility. Altogether, the nanoarchitectured PPy/CS may find application in the regeneration of bone defect.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Zhengnan
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, China.
authors.forename: Shishu
authors.initials: S
authors.lastname: Huang
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Tianrui
authors.initials: T
authors.lastname: He
authors.affiliation: Faculty of Light and Chemical, Guangdong University of Technology, Guangzhou 510006, China. Electronic address: tanguoxin@126.com.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Tan
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address: imcyning@scut.edu.cn.
authors.forename: Chengyun
authors.initials: C
authors.lastname: Ning
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010012:Osteogenesis / Q000187:drug effects; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D002809:Chondroitin Sulfates
keywords: Chondroitin sulphate; Conducting polymers; Nanoarchitectures; Polypyrrole