title: Non-osteotomy and osteotomy large animal fracture models in orthopedic trauma research.
abstract: Large animal fracture models are important in the field of orthopedic trauma research. New implants are tested in animals before being implanted into humans. Large animals like sheep or swine often are more properly to simulate conditions in humans, e.g. biomechanical demands, compared to rodents. Cited articles mainly analyze shock or fracture healing. Both osteotomy and non-osteotomy fracture models have been used in the past. However, comparative studies are rare and clear recommendation when to use which model are missing. This review will summarize large animal fracture models putting special emphasis on non-osteotomy fracture models.
authors.affiliation: Trauma Department, Hannover Medical School , Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Decker
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover , Germany.
authors.forename: Janin
authors.initials: J
authors.lastname: Reifenrath
authors.affiliation: Trauma Department, Hannover Medical School , Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Omar
authors.affiliation: Trauma Department, Hannover Medical School , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Krettek
authors.affiliation: Trauma Department, Hannover Medical School , Germany.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Müller
keywords: fracture; fracture healing; large animal; non-osteotomy fracture model; sheep