title: The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals.
abstract: BACKGROUND
  Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity.
  
  
  METHODS
  Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components.
  
  
  RESULTS
  Obese subjects had a significantly (P<0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P<0.05) compared to those with C allele.
  
  
  CONCLUSIONS
  We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biochemistry, Faculty of Science, Payame Noor University, Mashhad, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Emamian
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Oncology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
authors.forename: Alireza
authors.initials: A
authors.lastname: Pasdar
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Mirhafez
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Sadeghzadeh
authors.affiliation: Department of Biochemistry, Faculty of Science, Payame Noor University, Mashhad, Iran.
authors.forename: Masoud Saleh
authors.initials: MS
authors.lastname: Moghadam
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mohammad Reza
authors.initials: SM
authors.lastname: Parizadeh
authors.affiliation: Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.affiliation: Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D012694:Serine / Q000235:genetics; D014280:Triglycerides / Q000097:blood*
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides; D012694:Serine; D008071:Lipoprotein Lipase
keywords: CETP; LPL; Lipid metabolism; Obese subjects