title: Antimicrobial Chitosan based formulations with impact on different biomedical applications.
abstract: Owing to its physico-chemical characteristics, the biodegradable and biocompatible polymer derived from crustacean shells, Chitosan is one of the preferred candidates for green biomedical applications and also for several industries. Its solubility in acid solutions and ability to form complexes with anionic macromolecules to yield nanoparticles, microparticles and hydrogels, as well as the ability of chitosan based nanocomposites to remain stable at physiological pH recommend this polymer for the development of efficient drug delivery systems. This paper reviews the main utilities of chitosan as a drug delivery component and describes the most recent technologies which utilize this polymer for developing nanostructured systems with antimicrobial effect, offering a perspective of using these findings in new, ecological biomedical applications.
authors.forename: Marius
authors.initials: M
authors.lastname: Radulescu
authors.forename: Denisa
authors.initials: D
authors.lastname: Ficai
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Oprea
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.affiliation: University Politehnica of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Polizu St., 011061 Bucharest, Romania. ovidiu73@yahoo.com.
authors.forename: Alina M
authors.initials: AM
authors.lastname: Holban
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D004800:Enzymes, Immobilized; D006801:Humans
chemical_list: D000890:Anti-Infective Agents; D004800:Enzymes, Immobilized; D048271:Chitosan