title: Mitochondrial dynamics and viral infections: A close nexus.
abstract: Viruses manipulate cellular machinery and functions to subvert intracellular environment conducive for viral proliferation. They strategically alter functions of the multitasking mitochondria to influence energy production, metabolism, survival, and immune signaling. Mitochondria either occur as heterogeneous population of individual organelles or large interconnected tubular network. The mitochondrial network is highly susceptible to physiological and environmental insults, including viral infections, and is dynamically maintained by mitochondrial fission and fusion. Mitochondrial dynamics in tandem with mitochondria-selective autophagy 'mitophagy' coordinates mitochondrial quality control and homeostasis. Mitochondrial dynamics impacts cellular homeostasis, metabolism, and innate-immune signaling, and thus can be major determinant of the outcome of viral infections. Herein, we review how mitochondrial dynamics is affected during viral infections and how this complex interplay benefits the viral infectious process and associated diseases.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Mohsin
authors.initials: M
authors.lastname: Khan
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Gulam Hussain
authors.initials: GH
authors.lastname: Syed
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Seong-Jun
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: asiddiqui@ucsd.edu.
authors.forename: Aleem
authors.initials: A
authors.lastname: Siddiqui
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D063154:Mitochondrial Dynamics; D063306:Mitophagy; D014777:Virus Diseases / Q000378:metabolism* / Q000473:pathology
keywords: Hepatitis virus; Innate immunity; Mitochondrial fission and fusion; Mitophagy; Virus