title: [Effect of danhong huayu oral liquid combined with insulin on prevention and progression of early diabetic cardiomyopathy in rats].
abstract: OBJECTIVE
  To investigate effects of Danhong Huayu Koufuye (DHK), insulin and their combination on diabetic cardiomyopathy (DC) in streptozotocin (STZ, 50 mg/kg, ip)-induced diabetic rats.
  
  
  METHODS
  Rats were divided into five groups: normal control, diabetic treated with vehicle, insulin, DHK, and DHK plus insulin. The animals were treated once daily for 15 weeks starting one week after STZ injection.
  
  
  RESULTS
  The combination of DHK with insulin significantly reduced cardiac index (P < 0.05), serum LDH (P < 0.05), AST(P < 0.05), ALT(P < 0.05) and HDL-C (P < 0.05) level, and promoted pancreatic and cardiac morphological changes as compared with the model group.
  
  
  CONCLUSIONS
  It is suggested that DHK may be a valuable adjuvant therapy for DC.
authors.affiliation: Guangzhou University of Chinese Medicine, China. linbaoqin@gzutcm.edu.cn
authors.forename: Bao-Qin
authors.initials: BQ
authors.lastname: Lin
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Zhong
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Lin
authors.forename: Lu-Yun
authors.initials: LY
authors.lastname: Hu
authors.forename: Wen-Pei
authors.initials: WP
authors.lastname: Chen
authors.forename: Zi-Yang
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000375:Aging; D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental; D058065:Diabetic Cardiomyopathies / Q000188:drug therapy*; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007328:Insulin / Q000494:pharmacology*; D010179:Pancreas; D008517:Phytotherapy; D051381:Rats; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; C540581:danhong; D013311:Streptozocin