title: Metallic glass nanofibers in future hydrogel-based scaffolds.
abstract: Electrically conductive reinforced hydrogels offer a wide range of applications as three-dimensional scaffolds in tissue engineering. We report electrical and mechanical characterization of methacrylated gelatin (GelMA) hydrogel, containing palladium-based metallic glass nanofibers (MGNF). Also we show that the fibers are biocompatible and C2C12 myoblasts in particular, planted into the hybrid hydrogel, tend to attach to and elongate along the fibers. The MGNFs in this work were created by gas atomization. Ravel of fibers were embedded in the GelMA prepolymer in two different concentrations (0.5 and 1.0 mg/ml), and then the ensemble was cured under UV light, forming the hybrid hydrogel. The conductivity of the hybrid hydrogel was proportional to the fiber concentration.
authors.forename: Ramin Banan
authors.initials: RB
authors.lastname: Sadeghian
authors.forename: Samad
authors.initials: S
authors.lastname: Ahadian
authors.forename: Shin
authors.initials: S
authors.lastname: Yaginuma
authors.forename: Javier
authors.initials: J
authors.lastname: Ramón-Azcón
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Liang
authors.forename: Ken
authors.initials: K
authors.lastname: Nakajima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shiku
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Matsue
authors.forename: Koji S
authors.initials: KS
authors.lastname: Nakayama
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055119:Elastic Modulus; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D005780:Gelatin / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010165:Palladium; D005780:Gelatin; D051416:Focal Adhesion Protein-Tyrosine Kinases