title: Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD).
  
  
  METHODS
  Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conducted on the association between rs2043211 polymorphism and IBD using: (1) allele contrast, (2) the dominant model, (3) the recessive model, and (4) homozygote contrast. The pooled estimated of risk was obtained by random-effects model or fixed-effects model. Publication bias was assessed by Egger's test.
  
  
  RESULTS
  Eight relevant articles with a total of 10 534 IBD patients [6785 Crohn's disease (CD), 3713 ulcerative colitis (UC) and 36 indeterminate colitis (IC)] and 6755 healthy controls were included in the meta-analysis, which consisted of 12 studies, 12 for CD, 10 for UC, 2 for IC. There was no significant association between rs2043211 polymorphism and IBD, CD, and IC in overall population. However, stratified meta-analysis by ethnicity showed significant association between rs2043211 polymorphism and CD in the European population under the dominant model [odds ratio (OR) = 1.210, 95% confidence interval (CI) = 1.013-1.445, p = 0.036] and homozygote contrast (OR = 1.212, 95% CI = 1.005-1.461, p = 0.044).
  
  
  CONCLUSIONS
  Our meta-analysis results indicated significant association between rs2043211 polymorphism and the susceptibility to CD under the dominant model and homozygote contrast in the European population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui , PR China and.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Bao-Zhu
authors.initials: BZ
authors.lastname: Li
authors.forename: Han
authors.initials: H
authors.lastname: Cen
authors.forename: Wang-Dong
authors.initials: WD
authors.lastname: Xu
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000483:Alleles; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics*; D005799:Genes, Dominant; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D053468:CARD Signaling Adaptor Proteins; C455623:CARD8 protein, human; D009363:Neoplasm Proteins
keywords: CARD8; inflammatory bowel disease; meta-analysis; polymorphism