title: Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course.
abstract: Reversible cerebral vasoconstriction syndrome is a clinical and radiologic syndrome that represents a common presentation of a diverse group of disorders. The syndrome is characterized by thunderclap headache and reversible vasoconstriction of cerebral arteries, which can either be spontaneous or related to an exogenous trigger. The pathophysiology of reversible cerebral vasoconstriction syndrome is unknown, though alterations in cerebral vascular tone are thought to be a key underlying mechanism. The syndrome typically follows a benign course; however, reversible cerebral vasoconstriction syndrome may result in permanent disability or death in a small minority of patients secondary to complications such as ischemic stroke or intracranial hemorrhage.
authors.affiliation: From the Department of Diagnostic Radiology (T.R.M., R.S., D.G.), Section of Neuroradiology, University of Maryland Medical Center, Baltimore, Maryland.
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.affiliation: From the Department of Diagnostic Radiology (T.R.M., R.S., D.G.), Section of Neuroradiology, University of Maryland Medical Center, Baltimore, Maryland.
authors.forename: R
authors.initials: R
authors.lastname: Shivashankar
authors.affiliation: Department of Diagnostic Radiology (M.M.-B.), Section of Neuroradiology, University of Washington, Seattle, Washington.
authors.forename: M
authors.initials: M
authors.lastname: Mossa-Basha
authors.affiliation: From the Department of Diagnostic Radiology (T.R.M., R.S., D.G.), Section of Neuroradiology, University of Maryland Medical Center, Baltimore, Maryland Dgandhi@umm.edu.
authors.forename: D
authors.initials: D
authors.lastname: Gandhi
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D002539:Cerebral Arterial Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D002536:Cerebral Arteries / Q000503:physiopathology*; D005260:Female; D051270:Headache Disorders, Primary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology; D011379:Prognosis; D020521:Stroke / Q000209:etiology; D013577:Syndrome; D014661:Vasoconstriction; D020301:Vasospasm, Intracranial / Q000209:etiology