title: Immunological differences between classical phenothypes of multiple sclerosis.
abstract: Multiple sclerosis (MS), one of the most serious inflammatory and neurodegenerative conditions, is characterized by variable clinical courses - relapsing-remitting (RRMS), primary progressive (PPMS) and secondary progressive (SPMS). Although PPMS affects only 10-15% of the patient population, its course and pathophysiological and immunological background are distinct. In this review we present and discuss main differences between different types of MS, with particular focus on the underlying immunological mechanisms.
authors.affiliation: Department of Neurology, Poznan University School of Medicine, Poland; Department of Clinical Neuroimmunology, Poznan University School of Medicine, Poland. Electronic address: bluep@op.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Iwanowski
authors.affiliation: Department of Neurology, Poznan University School of Medicine, Poland; Department of Clinical Neuroimmunology, Poznan University School of Medicine, Poland; Neuroimmunological Unit, Institute of Experimental and Clinical Medicine, Polish Academy of Sciences, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Losy
mesh_terms: D001921:Brain / Q000276:immunology* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000145:classification / Q000276:immunology*; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology; D010641:Phenotype
keywords: Adhesion molecules; AntiGM3 antibodies; Demyelination; Neurodegeneration; PPMS; Primary progressive multiple sclerosis