title: Current wound healing procedures and potential care.
abstract: In this review, we describe current and future potential wound healing treatments for acute and chronic wounds. The current wound healing approaches are based on autografts, allografts, and cultured epithelial autografts, and wound dressings based on biocompatible and biodegradable polymers. The Food and Drug Administration approved wound healing dressings based on several polymers including collagen, silicon, chitosan, and hyaluronic acid. The new potential therapeutic intervention for wound healing includes sustained delivery of growth factors, and siRNA delivery, targeting microRNA, and stem cell therapy. In addition, environment sensors can also potentially utilize to monitor and manage microenvironment at wound site. Sensors use optical, odor, pH, and hydration sensors to detect such characteristics as uric acid level, pH, protease level, and infection - all in the hopes of early detection of complications.
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614-5807, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Dreifke
authors.affiliation: Undergraduate Program, Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Amil A
authors.initials: AA
authors.lastname: Jayasuriya
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614-5807, USA. Electronic address: a.jayasuriya@utoledo.edu.
authors.forename: Ambalangodage C
authors.initials: AC
authors.lastname: Jayasuriya
mesh_terms: D000208:Acute Disease; D001684:Biological Dressings; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D060833:Cellular Microenvironment; D048271:Chitosan / Q000627:therapeutic use; D002908:Chronic Disease; D003094:Collagen / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D035683:MicroRNAs / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000627:therapeutic use; D012825:Silicon / Q000627:therapeutic use; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs; D034741:RNA, Small Interfering; D006820:Hyaluronic Acid; D003094:Collagen; D048271:Chitosan; D012825:Silicon
keywords: Chronic wounds; Growth factors; Sensors; Stem cells; Wound dressings; Wound healing; siRNA