title: Health-Related Quality of Life among Children and Adolescents during Hematopoietic Stem Cell Transplant Recovery.
abstract: Health-related quality of life (HRQoL) has been noted to fluctuate among children during hematopoietic stem cell transplant (HSCT) recovery; however, the specific timing and associations of these changes are poorly understood. This repeated-measures study aimed to describe HRQoL changes among children and adolescents during the first 6 months of HSCT recovery and estimate the associations of demographic factors, diagnosis, transplant information, and symptoms with HRQoL. Twenty-three children and adolescents who received an allogeneic HSCT were recruited from a pediatric teaching institution in the southern United States. Demographic, diagnosis, and transplant information was obtained from the medical record. The Memorial Symptom Assessment questionnaire and the Peds Quality of Life Cancer Module (PedsQL CM) were completed at 1 month post-HSCT and then once monthly for 5 additional months. Mean HRQoL scores fluctuated during the study with the lowest mean HRQoL noted at 1 month post-HSCT and the highest mean HRQoL noted at 4 months post-HSCT. No significant differences in HRQoL scores were noted among demographic, diagnosis, or transplant factors. Feeling tired, sad, or worried or having insomnia at 1 month post-HSCT was negatively correlated to HRQoL. Nurses have opportunities to explore important issues with patients and need to be aware of fluctuations with HRQoL and factors associated with lower HRQoL during HSCT recovery.
authors.affiliation: Duke University School of Nursing, Durham, NC, USA cheryl.rodgers@duke.edu.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Rodgers
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Wills-Bagnato
authors.affiliation: Duke University, Center for the Study of Aging and Human Development, Durham, NC, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Sloane
authors.affiliation: Duke University School of Nursing, Durham, NC, USA.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Hockenberry
mesh_terms: D000293:Adolescent; D016497:Adolescent Health Services; D002648:Child; D002662:Child Health Services; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000451:nursing* / Q000523:psychology; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000451:nursing* / Q000523:psychology; D009859:Oncology Nursing; D010371:Pediatric Nursing; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: HSCT; adolescent; pediatric; quality of life; symptom