title: Application of molecular imaging technologies in antitumor drug development and therapy.
abstract: Molecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights into disease processes, which greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Zhang
authors.forename: Yi-Xiang
authors.initials: YX
authors.lastname: Wang
authors.forename: Jin-Bing
authors.initials: JB
authors.lastname: Liu
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Liao
authors.forename: Yang-Ying
authors.initials: YY
authors.lastname: Liao
authors.forename: Qiu-Lan
authors.initials: QL
authors.lastname: Zhou
authors.forename: Bing-Cheng
authors.initials: BC
authors.lastname: Li
authors.affiliation: Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China. winchen@vip.126.com.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Liang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends; D006801:Humans; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents