title: Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors.
abstract: Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP thin layer affords selectivity for specific recognition of MNZ molecules. For MNZ determination, the hybrid electrode shows two dynamic linear range of 5 × 10(-11) to 1 × 10(-9) mol L(-1) and 1 × 10(-9) to 1.4 × 10(-6) mol L(-1) with a remarkably low detection limit of 1.8 × 10(-11) mol L(-1) (S/N = 3). In addition, the sensor exhibits high binding affinity and selectivity towards MNZ with excellent reproducibility and stability. Finally, the reliability of MIP-NPGL for MNZ detection is proved in real fish tissue samples, demonstrating the potential for the proposed electrochemical sensors in monitoring drug and biological samples.
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi 832000, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi 832000, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi 832000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi 832000, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shihezi University, Shihezi 832000, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.affiliation: Nano Laboratory, Shandong Institute of Metrology, Jinan 250014, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Cao
authors.affiliation: Nano Laboratory, Shandong Institute of Metrology, Jinan 250014, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhao
authors.affiliation: 1] Institute for New Energy Materials and Low-Carbon Technologies, and School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China [2] Center for Advanced Energy Materials &Technology Research (AEMT), and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005399:Fishes / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008795:Metronidazole / Q000032:analysis* / Q000737:chemistry; D054802:Molecular Imprinting; D058608:Nanopores; D011108:Polymers / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry
chemical_list: D011108:Polymers; D013607:Tablets; D008795:Metronidazole; D006046:Gold