title: Validating the effect of muscle artifact suppression in localizing focal epilepsy.
abstract: Source localization of an epileptic seizure is becoming an important diagnostic tool in pre-surgical evaluation of epileptic patients. However, for localizing the epileptogenic zone precisely, the epileptic activity needs to be isolated from other activities that are not related to the epileptic source. In this study, we aim at an investigation of the effect of muscle artifact suppression by using a low-pass filter (LPF), independent component analysis (ICA), and a combination of ICA-LPF prior to source localization in focal epilepsy. These techniques were applied on the EEG data obtained from a left-temporal lobe epileptic patient by artificially contaminating the isolated spike interval, present in the four left-temporal electrodes, with a muscle artifact. The results show that the muscle artifact was fully suppressed. Applying the dipole and current-density reconstruction (CDR) source-analysis algorithms on the filtered data, we were able to identify the location of the epileptogenic zone similar to that of the original undistorted data.
authors.forename: K G
authors.initials: KG
authors.lastname: Mideksa
authors.forename: A
authors.initials: A
authors.lastname: Santillan-Guzman
authors.forename: N
authors.initials: N
authors.lastname: Japaridze
authors.forename: A
authors.initials: A
authors.lastname: Galka
authors.forename: U
authors.initials: U
authors.lastname: Stephani
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: U
authors.initials: U
authors.lastname: Heute
authors.forename: M
authors.initials: M
authors.lastname: Muthuraman
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D009132:Muscles / Q000503:physiopathology*