title: Electrochemical biochip for applications to wireless and batteryless monitoring of free-moving mice.
abstract: A multi-sensing platform for applications in wireless and batteryless monitoring of free-moving small animals is presented in this paper. The proposed platform hosts six sensors: four biosensors for sensing of both disease biomarkers and therapeutic compounds, and two further sensors (T and pH) for biosensor calibration. Electrodeposition of Multi-Walled Carbon Nanotubes (MWCNTs) and the subsequent function-alization with proper enzymes is used to assure sensitivity and specificity in electrochemical biosensing. The realized sensors are demonstrated to be capable of measuring several parameters: lactate with a sensitivity of 77±26 μA/mM· cm(2) and a limit of detection (LOD) of 4±1 μM; glucose with a sensitivity of 63±15 μA/mM· cm(2) and a LOD of 8±2 μM; Etoposide (a well known anti-cancer agent) with a sensitivity of 0.15±0.04 mA/mM· cm(2) and a LOD of 4±1 μM; Open Circuit Potential (OCP) measurements are used on a Pt/IrOx junction to sense pH with a sensitivity of around -75±5mV/pH; while a Pt resistive thermal device is used to measure physiological temperature-range with an average sensitivity of 0.108±0.001 kΩ/°C.
authors.forename: Camilla
authors.initials: C
authors.lastname: Baj-Rossi
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Micheli
authors.forename: Sandro
authors.initials: S
authors.lastname: Carrara
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002138:Calibration; D011211:Electric Power Supplies; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005947:Glucose / Q000032:analysis; D005949:Glucose Oxidase; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D055442:Metabolome; D051379:Mice; D008991:Monitoring, Physiologic / Q000379:methods*; D009068:Movement; D013696:Temperature; D059015:Wireless Technology
chemical_list: D000970:Antineoplastic Agents; D005949:Glucose Oxidase; D005947:Glucose