title: Leflunomide-induced acute interstitial pneumonia in a patient treated for rheumatoid arthritis.
abstract: Leflunomide is a disease-modifying anti-rheumatic drug that is used in patients with rheumatoid arthritis (RA), who do not respond well to standard RA treatment. Leflunomide therapy may, however, be related with significant pulmonary complications in predisposed individuals. We present a patient with RA treated with leflunomide, in whom leflunomide lung injury had a fatal outcome. Potential risk factors for pulmonary complications of leflunomide treatment and the management of patients with leflunomide lung injury are discussed.
authors.affiliation: krzysztof.karwat@wum.edu.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Maskey-Warzęchowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Karwat
authors.forename: Benedykt
authors.initials: B
authors.lastname: Szczepankiewicz
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szołkowska
authors.forename: Ryszarda
authors.initials: R
authors.lastname: Chazan
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects*; D000077339:Leflunomide; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic
chemical_list: D000276:Adjuvants, Immunologic; D007555:Isoxazoles; D000077339:Leflunomide