title: Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing.
abstract: BACKGROUND
  N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly leads to heart failure. However, the relationship between resting heart rate and NT-proBNP is unclear.
  
  
  OBJECTIVE
  This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population.
  
  
  METHODS
  We evaluated the relativity between resting heart rate and plasma levels of NT-proBNP in 1,567 participants (mean age 61.0 years, range 21-96 years) from a community-based population in Beijing, People's Republic of China.
  
  
  RESULTS
  In patients with high resting heart rate (≥75 beats/min), NT-proBNP was higher than in those having low resting heart rate (<75 beats/min). In multiple linear stepwise regression analysis, plasma NT-proBNP was associated with resting heart rate (partial correlation coefficient, 0.82; 95% confidence interval, 0.18-1.51; P=0.011). A subsequent subgroup analysis revealed that the association between resting heart rate and plasma NT-proBNP was strengthened in subjects over 60 years old (partial correlation coefficient 1.28; 95% confidence interval, 0.49-2.36; P=0.031); while the relativity between resting heart rate and plasma NT-proBNP was not emerged in the younger subgroup (<60 years old).
  
  
  CONCLUSIONS
  Resting heart rate was associated with plasma NT-proBNP in the elderly, which indicated a relationship between resting heart rate and cardiac function damage.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Cao
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
mesh_terms: D002681:China / Q000453:epidemiology; D055812:Community-Based Participatory Research; D042241:Early Diagnosis; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012146:Rest / Q000502:physiology; D013223:Statistics as Topic
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal pro-brain natriuretic peptide; cardiac function; epidemiology; relationship; resting heart rate