title: Reduction of functionalized tertiary phosphine oxides with BH3.
abstract: A direct stereoselective conversion of tertiary hydroxyalkylphosphine oxides to the corresponding tertiary hydroxyalkylphosphine-boranes involving facile reduction of the P═O bond by BH3 under mild conditions has been developed. The unprecedented facility of reduction of the strong P═O bond by BH3, a mild reducing agent, has been achieved through an intramolecular P═O···B complexation directed by proximal α- or β-hydroxy groups present in the phosphine oxide structures. As established by two chemical correlations, the developed transformation of hydroxyalkylphosphine oxides into hydroxyalkylphosphine-boranes takes place with complete inversion of configuration at P.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Maria Curie Sklodowska University , Gliniana Street 33, Lublin 20-614, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Sowa
authors.forename: Marek
authors.initials: M
authors.lastname: Stankevič
authors.forename: Anna
authors.initials: A
authors.lastname: Szmigielska
authors.forename: Hanna
authors.initials: H
authors.lastname: Małuszyńska
authors.forename: Anna E
authors.initials: AE
authors.lastname: Kozioł
authors.forename: K Michał
authors.initials: KM
authors.lastname: Pietrusiewicz