title: [Abscopal effect in the treatment of malignant melanoma].
abstract: BACKGROUND
  The clearance of non-irradiated tumors after localized radiation therapy is known as the abscopal effect.
  
  
  METHODS
  In the present case report we initiated a combined therapeutic approach based on sequential administration of ipilimumab plus temozolomide in combination with radiotherapy. The treatment regime was well tolerated and resulted in unusually long disease stabilization and in a complete response of brain and kidney metastases. Thus, it is speculated that the clinical response was the result of an abscopal effect.
  
  
  CONCLUSIONS
  The present case report highlights the possible clinical benefit of the abscopal effect in the treatment of malignant melanoma.
authors.affiliation: Klinische Abteilung für Onkologie, Comprehensive Cancer Center, Universitätsklinik für Innere Medizin I, AKH Wien, Medizinische Universität Wien, Währingergürtel 18-20, 1090, Wien, Österreich, Christiane.Thallinger@meduniwien.ac.at.
authors.forename: C
authors.initials: C
authors.lastname: Thallinger
authors.forename: G
authors.initials: G
authors.lastname: Prager
authors.forename: H
authors.initials: H
authors.lastname: Ringl
authors.forename: C
authors.initials: C
authors.lastname: Zielinski
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000556:secondary* / Q000628:therapy*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000628:therapy*; D016896:Treatment Outcome