title: Potential cell-specific functions of CXCR4 in atherosclerosis.
abstract: The chemokine CXCL12 and its receptor CXCR4 form an important axis contributing to cellular functions in homeostasis and disease. In addition, the atypical CXCL12 receptor CXCR7 may shape the availability and function of CXCL12. Further to their role through progenitor cell mobilization, CXCL12 and CXCR4 may affect native atherogenesis by modifying atherosclerosis-relevant cellular functions. This short review intends to provide a concise summary of current knowledge with regards to cell-specific functions of CXCL12 and its receptors CXCR4 and CXCR7 with potential implications for the initiation and progression of atherosclerosis.
authors.affiliation: Prof. Dr. med. Christian Weber, Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Pettenkoferstraße 9, 80336 Munich, Germany, E-mail: chweber@med.lmu.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Döring
authors.forename: Heidi
authors.initials: H
authors.lastname: Noels
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology; D001773:Blood Cells / Q000276:immunology*; D054377:Chemokine CXCL12 / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D019317:Evidence-Based Medicine; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology; D018448:Models, Immunological; D018384:Oxidative Stress / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology; D054387:Receptors, CXCR / Q000276:immunology*; D019718:Receptors, CXCR4 / Q000276:immunology*
chemical_list: C501896:ACKR3 protein, human; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D016207:Cytokines; D007155:Immunologic Factors; D017382:Reactive Oxygen Species; D054387:Receptors, CXCR; D019718:Receptors, CXCR4
keywords: CXCL12; CXCR4; CXCR7