title: Large pore mesoporous silica nanomaterials for application in delivery of biomolecules.
abstract: Various approaches for the synthesis of mesoporous silicate nanoparticles (MSN) with large pore (LP) diameters (in the range of 3-50 nm) are reviewed in this article. The work also covers the construction of magnetic analogues of large pore-mesoporous silica nanoparticles (LPMMSN) and their biomedical applications. The constructed materials exhibit vast potential for application in the loading and delivery of large drug molecules and biomolecules. Literature reports on the application of LPMSN and LPMMSN materials for the adsorption and delivery of proteins, enzymes, antibodies, and nucleic acids are covered in depth, which exemplify their highly potent characteristics for use in drug and biomolecule delivery to diseased tissues.
authors.affiliation: Faculty of Pharmacy, European University, Trg mladenaca 5, 21000 Novi Sad, Serbia. nikola.knezevic@faculty-pharmacy.com.
authors.forename: Nikola Ž
authors.initials: NŽ
authors.lastname: Knežević
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005583:Fourier Analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D009696:Nucleic Acids; D010316:Particle Size; D016062:Porosity; D017640:Silicates / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering
chemical_list: D004337:Drug Carriers; D009696:Nucleic Acids; D017640:Silicates; D012822:Silicon Dioxide