title: Infliximab, methotrexate and their combination for the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
abstract: We performed a systematic review to evaluate the efficacy and safety of infliximab + methotrexate (IFX + MTX) regimens versus MTX alone or in combination with other disease-modifying anti-rheumatic drugs (DMARDs). We searched through major databases, the grey literature and did a manual search. Two independent reviewers conducted the selection, data extraction and analysis of the quality of the studies. Meta-analysis was conducted using Review Manager(®) 5.1 software. Nine trials were included. The mean modified Jadad score was 4.4, but only one study showed low risk of bias. IFX + MTX regimen presented better responses in clinical outcomes of ACR and DAS28 by up to 54 weeks, and of radiographic progression by up to 104 weeks. Withdrawals due to lack of efficacy was lower in the IFX + MTX group. No significant difference in adverse events was observed. The IFX + MTX combination is more effective than treatment with MTX alone or DMARDs combination. This regimen presented good tolerability in patients previously treated with DMARDs, not treated with MTX or with insufficient responses to MTX. The efficacy of IFX + MTX is noted primarily during initial periods of treatment. High doses of IFX were as effective as the standard dose, but with possible higher risk of serious infections. Therefore, we advise clinicians to use the standard dose of IFX 3 mg/kg every 8 weeks.
authors.affiliation: Programa de Pós-Graduação em Saúde Pública, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. Electronic address: juliana.olic@gmail.com.
authors.forename: Juliana de Oliveira
authors.initials: Jde O
authors.lastname: Costa
authors.affiliation: Programa de Pós Graduação em Medicamentos e Assistência Farmacêutica, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Lívia Lovato Pires de
authors.initials: LL
authors.lastname: Lemos
authors.affiliation: Programa de Pós-Graduação em Saúde Pública, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Marina Amaral de Ávila
authors.initials: MA
authors.lastname: Machado
authors.affiliation: Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Belo Horizonte, Belo Horizonte, MG, Brasil.
authors.forename: Alessandra Maciel
authors.initials: AM
authors.lastname: Almeida
authors.affiliation: Departamento do Sistema Locomotor, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Adriana Maria
authors.initials: AM
authors.lastname: Kakehasi
authors.affiliation: Medicina Baseada em Evidências/PGMIT, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Vânia de Eloísa
authors.initials: Vde E
authors.lastname: Araújo
authors.affiliation: Departamento de Medicina Preventiva e Social, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Mariângela Leal
authors.initials: ML
authors.lastname: Cherchiglia
authors.affiliation: Departamento de Medicina Preventiva e Social, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
authors.forename: Eli Iola Gurgel
authors.initials: EI
authors.lastname: Andrade
authors.affiliation: Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Belo Horizonte, Belo Horizonte, MG, Brasil.
authors.forename: Francisco de Assis
authors.initials: Fde A
authors.lastname: Acurcio
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D000069285:Infliximab / Q000008:administration & dosage*; D008727:Methotrexate / Q000008:administration & dosage*
chemical_list: D018501:Antirheumatic Agents; D000069285:Infliximab; D008727:Methotrexate
keywords: Artrite reumatoide; Efficacy; Eficácia; Infliximab; Infliximabe; Metanálise; Meta‐analysis; Revisão sistemática; Rheumatoid arthritis; Systematic review