title: Cerebral venous sinus thrombosis may be associated with hepatitis B virus infection: a preliminary finding.
abstract: OBJECTIVE
  To assess the clinical significance of hepatitis B virus (HBV) infection in patients with cerebral venous sinus thrombosis (CVST).
  
  
  METHODS
  Twenty-two patients with CVST confirmed by magnetic resonance venography (MRV) or digital subtraction angiography (DSA) and 743 controls with ischemic stroke confirmed by magnetic resonance imaging (MRI) were analyzed retrospectively.
  
  
  RESULTS
  Among all researches, HBV surface antigen (HBsAg)-positive rate was high. Six of the 22 (27.3%) confirmed cases had HBsAg. However, HBsAg-positive rate in patients with ischemic stroke was only 45 of the 743 cases (6.1%), closed to the average prevalence in China (∼ 8.6%), but much lower than the positive rate in CVST patients (27.3 vs 6.1%, P  =  0.002). Odd ratio (OR) value between HBsAg-positive CVST patients (27.3%) and HBsAg-positive ischemic stroke patients (6.1%) was 5.78. The OR value between HBsAg-positive CVST patients (27.3%) and average prevalence of HBV infection in China (8.6%) was nearly 3.99. It meant that HBV infection might be a risk factor for CVST. However, there existed no statistically significant difference in HBV surface antibody (HBsAb), HBV e antigen (HBeAg), HBV e antibody (HBeAb), and HBV central antibody (HBcAb)-positive rate. The HBV surface antigen (HBsAg)-positive CVST patients did not show worse liver function. Most of them were inactive HBV carriers.
  
  
  CONCLUSIONS
  Hepatitis B virus infection may be a risk factor for CVST.
authors.forename: Fulan
authors.initials: F
authors.lastname: Shan
authors.forename: Cong
authors.initials: C
authors.lastname: Gao
authors.forename: Youming
authors.initials: Y
authors.lastname: Long
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Zheng
authors.forename: Mengyu
authors.initials: M
authors.lastname: Chen
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Fan
authors.forename: Jianrui
authors.initials: J
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000453:epidemiology / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000503:physiopathology*; D006515:Hepatitis B virus; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000453:epidemiology / Q000503:physiopathology*; D020521:Stroke / Q000453:epidemiology / Q000503:physiopathology; D055815:Young Adult
keywords: Cerebral venous sinus thrombosis,; Hepatitis B virus infection,; Ischemic stroke