title: The Preventive Effect of Dexmedetomidine Against Postoperative Intra-abdominal Adhesions in Rats.
abstract: This study aimed to determine the possible preventive effects of dexmedetomidine on postoperative intra-abdominal adhesions. Dexmedetomidine is a highly selective and potent α2 adrenergic agonist with sedative, analgesic, anxiolytic, sympatholytic, hemodynamic, and diuretic properties. In recent years, investigations have shown that dexmedetomidine possesses secondary antioxidant and also anti-inflammatory effects. Thirty Wistar albino male rats were randomized and divided into 3 groups of 10 animals each: group 1, sham-operated; group 2, cecal abrasion + peritoneal dissection; group 3, cecal abrasion + peritoneal dissection followed by daily intravenous injection of 10 μg/kg dexmedetomidine for 10 days. The animals were killed on postoperative day 21. Blood and cecal samples were taken for biochemical and histopathologic evaluation. In this study, biochemical and pathologic parameters were significantly better in the cecal abrasion + peritoneal dissection + dexmedetomidine group when compared with the cecal abrasion + peritoneal dissection group. Tissue malondialdehyde, myeloperoxidase, total sulfhydryl, and catalase were found to be significantly different between the cecal abrasion/peritoneal dissection + dexmedetomidine and the cecal abrasion/peritoneal dissection groups. Plasma malondialdehyde and total sulfhydryl values were also statistically different between these groups (P < 0.05). Statistical analyses of mean pathologic scores showed that the histopathologic damage in the cecal abrasion/peritoneal dissection + dexmedetomidine group was significantly less than the damage in the control group (P < 0.05 for all pathologic parameters). The results of this study show that dexmedetomidine had a significant preventive effect on postoperative intra-abdominal adhesions. We concluded that these effects might be due to antioxidant and anti-inflammatory activities.
authors.affiliation: 1 Department of General Surgery, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kuru
authors.forename: Osman Bahadir
authors.initials: OB
authors.lastname: Bozkirli
authors.forename: Aziz Mutlu
authors.initials: AM
authors.lastname: Barlas
authors.forename: Mehmet Esat
authors.initials: ME
authors.lastname: Duymus
authors.forename: Mehmet
authors.initials: M
authors.lastname: Senes
authors.forename: Nihat
authors.initials: N
authors.lastname: Yumusak
authors.forename: Cevdet
authors.initials: C
authors.lastname: Yilmaz
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002432:Cecum / Q000473:pathology / Q000601:surgery*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D007275:Injections, Intravenous; D008297:Male; D010537:Peritoneum / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D020927:Dexmedetomidine
keywords: Anti-inflammatory; Antioxidant; Dexmedetomidine; Intraabdominal adhesions; Oxidative stress