title: TET2 loss, a rescue of JAK2V617F HSCs.
abstract: In this issue of Blood, Chen et al and Kameda et al demonstrate that Tet2 loss has 2 effects in Jak2V617F mice: it increases both the severity of the myeloproliferative disorders and the self-renewal properties of the Jak2V617F hematopoietic stem cells (HSCs).
authors.affiliation: INSTITUT DE CANCÉROLOGIE GUSTAVE ROUSSY.
authors.forename: William
authors.initials: W
authors.lastname: Vainchenker
authors.affiliation: INSTITUT DE CANCÉROLOGIE GUSTAVE ROUSSY.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Plo
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D049308:Dioxygenases; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D053614:Janus Kinase 2 / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C551914:Tet2 protein, mouse; C507926:Jak2 protein, mouse; D053614:Janus Kinase 2