title: The impact of method on kidney graft and patient survival in kidney-pancreas transplantations for type I diabetes mellitus.
abstract: Patients who develop end-stage renal disease (ESRD) associated with Type I Diabetes Mellitus may receive kidney alone (KA) transplantation, simultaneous pancreas-kidney (SPK) transplantation, or a pancreas after kidney (PAK) transplantation. The goal of this study is to examine the long-term impact of pancreas transplantation on kidney graft and patient survival rates. A total of 85 transplantation cases, consisting of 30 that received living donor KA, 21 that received SPK, and 34 that received PAK, from 2003-2010 at Akdeniz University Organ Transplantation Institute were retrospectively screened. There was a graft loss in 4 cases from the KA group, and in 1 case from each of the SPK and PAK groups. The five-year kidney graft survival rates were 86.7% in KA, 95.2% in SPK, and 97.1% in PAK. There was a single patient loss in both KA and SPK. The kidney survival percentages were higher in SPK and PAK groups compared to the KA group. Therefore, SPK should be the primary preference in these patients; however, for the cases that have a living donor, pancreas transplantation should be considered after kidney transplantation, or the patients can be followed-up on with close blood sugar control.
authors.affiliation: 1 Department of General Surgery, Medical Faculty, Akdeniz University, Antalya, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dinckan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aliosmanoglu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kocak
authors.forename: Ayhan
authors.initials: A
authors.lastname: Mesci
authors.forename: Hasan
authors.initials: H
authors.lastname: Altunbas
authors.forename: Alihan
authors.initials: A
authors.lastname: Gurkan
mesh_terms: D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Kidney; Kidney survival; Pancreas; Patient survival; Transplantation