title: Chronic pain: cytokines, lymphocytes and chemokines.
abstract: Chronic pain is a debilitating condition and, in most cases, difficult to treat. A prominent example of this is neuropathic pain. Understanding pathophysiological mechanisms of pain and, therefore, making this knowledge into an effective treatment is still a challenge to experts. Pain can now be considered as a neuro-immune disorder, since recent data indicate critical involvement of innate and adaptive immune responses following injury, and this interaction plays an important role in the onset and perpetuation of chronic pain. The aim of this article is to review the relationship between immune system and chronic pain, especially about neuropathic pain, and focusing on cytokines, chemokines and lymphocytes.
authors.forename: Marcia
authors.initials: M
authors.lastname: de Miguel
authors.forename: Durval Campos
authors.initials: DC
authors.lastname: Kraychete
authors.affiliation: Reitor Miguel Calmon Avenue, Canela Valey, Salvador, Bahia, ZIP CODE: 40.110-100, Brazil. marciademiguel@hotmail.com.
authors.forename: Roberto Jose
authors.initials: RJ
authors.lastname: Meyer Nascimento
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D059350:Chronic Pain / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000502:physiology*; D009420:Nervous System / Q000276:immunology*; D015213:Neuroimmunomodulation
chemical_list: D018925:Chemokines; D016207:Cytokines