title: Gliomatosis peritonei: a particular entity with specific outcomes within the growing teratoma syndrome.
abstract: OBJECTIVE
  Ovarian immature teratoma may be associated with peritoneal spread that could, after adjuvant chemotherapy, develop into disease exclusively composed of mature implants (growing teratoma syndrome) and/or gliomatosis peritonei (GP), defined as the presence of pure mature glial tissue. However, very few specific series are devoted to the outcomes of pure GP. This was the aim of the present study.
  
  
  METHODS
  From 1997 to 2013, data concerning patients treated for stage II/III immature teratoma were reviewed. All slides were reviewed by an expert pathologist. Patients with ovarian cancer associated with peritoneal spread in the form of pure GP (initially if patients were treated without adjuvant treatment or after adjuvant chemotherapy if done) were analyzed.
  
  
  RESULTS
  Ten patients fulfilled the inclusion criteria. The median age of patients at diagnosis was 36 years (range, 14-41 years). Six patients had undergone a conservative treatment. Five patients had macroscopic residual disease at the end of surgery.The median duration of follow-up from the diagnosis of GP was 39 months (range, 6-114 months). Six patients had undergone secondary surgery. Among them, 5 had incompletely resected macroscopic GP. No patients had died of their disease. All patients were asymptomatic at the time of the last consultation (1 of them with abnormal radiologic imaging).
  
  
  CONCLUSIONS
  Gliomatosis peritonei is a particular entity of the condition described as growing teratoma syndrome because residual peritoneal disease can be asymptomatic totally stable over a long period which raises the question of a more conservative surgical approach in patients with massive peritoneal spread.
authors.affiliation: Departments of *Gynecologic Surgery, and †Pathology, and ‡UniversityParis Sud, Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Enrica
authors.initials: E
authors.lastname: Bentivegna
authors.forename: Clementine
authors.initials: C
authors.lastname: Gonthier
authors.forename: Catherine
authors.initials: C
authors.lastname: Uzan
authors.forename: Catherine
authors.initials: C
authors.lastname: Genestie
authors.forename: Pierre
authors.initials: P
authors.lastname: Duvillard
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gouy
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D018365:Neoplasm, Residual; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D013577:Syndrome; D013724:Teratoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D055815:Young Adult