title: A review of the expected effects of antimicrobials in bovine respiratory disease treatment and control using outcomes from published randomized clinical trials with negative controls.
abstract: Bovine respiratory disease (BRD) remains a major disease from an economic and an animal welfare standpoint in beef production systems. Antimicrobial administration is a mainstay in the control of and therapeutic treatment of acute BRD. Judicious use of antimicrobials remains paramount to ensure efficacy of treatment remains acceptable. A systemic review was conducted in the scientific literature, the objective of which was to present a cumulative review of the data from published randomized clinical trials using a negative control in the treatment and control of BRD and using the number needed to treat as a means to effectively convey this information to bovine practitioners.
authors.affiliation: ICCM, Kansas State University College of Veterinary Medicine, P200 Mosier Hall, Manhattan, KS 66506, USA. Electronic address: kdd5257@vet.k-state.edu.
authors.forename: Keith D
authors.initials: KD
authors.lastname: DeDonder
authors.affiliation: ICCM, Kansas State University College of Veterinary Medicine, P200 Mosier Hall, Manhattan, KS 66506, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Apley
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy*; D002417:Cattle; D005260:Female; D016032:Randomized Controlled Trials as Topic / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents
keywords: Antibiotic resistance; Antibiotic susceptibility; Antimicrobial drugs; Bovine respiratory disease; Evidence based medicine; Number needed to treat; Randomized clinical trial