title: Posterior Reversible Encephalopathy Syndrome (PRES) as a Complication of Immunosuppressive Therapy in Renal Transplantation in Children.
abstract: Although kidney transplantation is by far the best method of renal replacement therapy, organ receiver is still not spared of eventual toxic consequences of drugs that are in charge of keeping the transplanted kidney functional. Both calcineurin inhibitors, of which tacrolimus more often, occasionally lead to neurotoxic side effects, mostly mild and reversible and dose-dependent in nature, but they can also be very severe or even fatal. It is very important to be aware of possible neurotoxic effects, to confirm them radiologically, and to prevent or reduce drug effects on nervous system. Sometimes the reduction of dose or substitution with another drug with similar mechanism effect is sufficient to terminate the neurotoxic effects of the drug and still not jeopardize the function of transplanted organ.
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Emir
authors.initials: E
authors.lastname: Hodzic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Majda
authors.initials: M
authors.lastname: Brcic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Mirza
authors.initials: M
authors.lastname: Atic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Alma
authors.initials: A
authors.lastname: Halilcevic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Amila
authors.initials: A
authors.lastname: Jasarevic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Mirna
authors.initials: M
authors.lastname: Aleckovic-Halilovic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Davor
authors.initials: D
authors.lastname: Trojak
authors.affiliation: University Clinical Center Tuzla, Clinic for Diseases of Children, Tuzla, Bosnia and Herzegovina.
authors.forename: Nedima
authors.initials: N
authors.lastname: Atic
authors.affiliation: University Clinical Center Tuzla, Clinic for Diseases of Children, Tuzla, Bosnia and Herzegovina.
authors.forename: Snezana
authors.initials: S
authors.lastname: Zulic
authors.affiliation: University Clinical Center Tuzla, Clinic for Surgery, Tuzla, Bosnia and Herzegovina.
authors.forename: Zlatan
authors.initials: Z
authors.lastname: Mehmedovic
authors.affiliation: University Clinical Center Tuzla, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
authors.forename: Ivana
authors.initials: I
authors.lastname: Iveljic
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000534:rehabilitation; D008279:Magnetic Resonance Imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000473:pathology; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D006435:Renal Dialysis; D012640:Seizures / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus
keywords: Posterior reversible encephalopathy syndrome; kidney transplantation