title: Oral contraceptive use and saliva diurnal pattern of metabolic steroid hormones in young healthy women.
abstract: BACKGROUND
  The impact of oral contraceptives (OCs) on the saliva diurnal pattern of metabolic steroid hormones remained unknown.
  
  
  METHODS
  Saliva samples were taken from young healthy women (11 OC users, 10 non-OC users) to analyze cortisol, dehydroepiandrosterone (DHEA) and testosterone 4 times (days 1, 8, 15 and 22) over one menstrual cycle.
  
  
  RESULTS
  OC use decreased saliva testosterone concentrations (p<.01) under all conditions of day and time, but not saliva cortisol. OC also decreased saliva DHEA concentrations during the first part of the day (p<.05), with a dampened amplitude in its diurnal pattern.
  
  
  CONCLUSIONS
  The clinical relevance requires further study.
authors.affiliation: Laboratoire CIAMS, Université Paris Sud-Université Orléans, France.
authors.forename: N
authors.initials: N
authors.lastname: Vibarel-Rebot
authors.affiliation: Laboratoire CIAMS, Université Paris Sud-Université Orléans, France.
authors.forename: N
authors.initials: N
authors.lastname: Rieth
authors.affiliation: Département des Analyses, AFLD, France.
authors.forename: F
authors.initials: F
authors.lastname: Lasne
authors.affiliation: Laboratoire M2S, Université Rennes 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Jaffré
authors.affiliation: Laboratoire CIAMS, Université Paris Sud-Université Orléans, France; Département des Analyses, AFLD, France. Electronic address: katia.collomp@univ-orleans.fr.
authors.forename: K
authors.initials: K
authors.lastname: Collomp
mesh_terms: D002940:Circadian Rhythm; D003277:Contraceptives, Oral, Combined / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000032:analysis*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D016912:Levonorgestrel / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*; D013739:Testosterone / Q000032:analysis*; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; C072593:ethinyl estradiol, levonorgestrel drug combination; D013739:Testosterone; D004997:Ethinyl Estradiol; D003687:Dehydroepiandrosterone; D016912:Levonorgestrel; D006854:Hydrocortisone
keywords: Circadian rhythm; Contraception; Cortisol; DHEA; Testosterone