title: The Use of Limited Fluid Resuscitation and Blood Pressure-Controlling Drugs in the Treatment of Acute Upper Gastrointestinal Hemorrhage Concomitant with Hemorrhagic Shock.
abstract: The aim of this study was to evaluate the usefulness of the limited fluid resuscitation regimen combined with blood pressure-controlling drugs in treating acute upper gastrointestinal hemorrhage concomitant with hemorrhagic shock. A total of 51 patients were enrolled and divided into a group that received traditional fluid resuscitation group (conventional group, 24 patients) and a limited fluid resuscitation group (study group, 27 patients). Before and after resuscitation, the blood lactate, base excess, and hemoglobin values, as well as the volume of fluid resuscitation and resuscitation time were examined. Compared with conventional group, study group had significantly better values of blood lactate, base excess, and hemoglobin (all p < 0.05). In addition, both volume of fluid resuscitation and resuscitation time were significantly (p < 0.05) lower in these patients. Limited fluid resuscitation combined with blood pressure-controlling drugs effectivelyxxx maintains blood perfusion of vital organs, improves whole body perfusion indicators, reduces the volume of fluid resuscitation, and achieves better bleeding control and resuscitation effectiveness.
authors.affiliation: Intensive Care Unit, Xuzhou Central Hospital, No. 199 The Liberation of South Road, Xuzhou, 221009, Jiangsu, China. contribution070@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.affiliation: Intensive Care Unit, Xuzhou Central Hospital, No. 199 The Liberation of South Road, Xuzhou, 221009, Jiangsu, China.
authors.forename: Mao-Qin
authors.initials: MQ
authors.lastname: Li
authors.affiliation: Intensive Care Unit, Xuzhou Central Hospital, No. 199 The Liberation of South Road, Xuzhou, 221009, Jiangsu, China.
authors.forename: Jia-Qiong
authors.initials: JQ
authors.lastname: Li
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000188:drug therapy* / Q000628:therapy; D006439:Hemodynamics; D006489:Hemostatic Techniques / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy
chemical_list: D000959:Antihypertensive Agents
keywords: Blood pressure-controlling drugs; Hemorrhagic shock; Limited fluid resuscitation; Upper gastrointestinal hemorrhage