title: Modeling prediction of a generalized habituation deficit in decompensated tinnitus sufferers.
abstract: The pathologic auditory sensation in decompensated tinnitus patients is accompanied by the inability to habituate even temporary to this sound. This disability might originate from simultaneous activation of brain areas for the appraisal of the stimulus valence as, e.g., the limbic system. This coactivation of limbic areas is likely to modulate the degree and persistence of selective attention assigned to the tinnitus stream, which in turn could also explain interindividual differences in tinnitus loudness perception. Preliminary studies demonstrate that the amount of allocated attention and the habituation deficit can be mapped to changes in auditory late evoked responses (ALRs). Utilizing a numerical model for the simulation of ALRs we were able to predict a general habituation behavior in two patient groups with different degrees of tinnitus severity. Evaluating the instantaneous phase of simulated and measured ALRs by its von Mises concentration parameter, we verify a habituation deficit relative to the degree of decompensation and thus provide additional support for our neurofunctional model of limbic influences on neural processing of sensory information.
authors.forename: L
authors.initials: L
authors.lastname: Haab
authors.forename: Z
authors.initials: Z
authors.lastname: Mortezapouraghdam
authors.forename: D J
authors.initials: DJ
authors.lastname: Strauss
mesh_terms: D001307:Auditory Perception; D005072:Evoked Potentials, Auditory; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D008959:Models, Neurological; D014012:Tinnitus / Q000503:physiopathology*