title: Evaluation, prevention and management of cancer therapy-induced cardiotoxicity: a contemporary approach for clinicians.
abstract: OBJECTIVE
  While targeted therapies have improved cancer outcomes, unique cardiovascular toxicities are increasingly recognized, particularly when administered sequentially after anthracyclines or radiation. Patients with cancer therapy-induced cardiotoxicity benefit from collaborative care involving cardiology and oncology, leading to a new interdisciplinary field called cardio-oncology. The present review will highlight contemporary clinical issues in cardio-oncology.
  
  
  RESULTS
  Recently, risk factors for cancer therapy-induced cardiotoxicity have been evaluated in real-world rather than in clinical trial patients. Biomarkers and advanced echocardiography are emerging as sensitive tools for preclinical identification of cancer therapy-induced cardiotoxicity. Single-center studies suggest that cancer therapy-induced cardiotoxicity responds to prompt heart failure medical treatment, and such therapy may even prevent cardiotoxicity.
  
  
  CONCLUSIONS
  Modern cancer therapy has short-term cardiac risk that may require collaborative management by clinicians with expertise in cardiology and oncology. The increased effectiveness of modern cancer therapy is resulting in a growing population of cancer survivors who are at long-term risk for cardiovascular disease. The present review of contemporary clinical issues in cardio-oncology will be of interest to healthcare providers who manage cardiotoxicity during cancer therapy, and who follow patients who survive cancer but face increased long-term cardiovascular risk.
authors.affiliation: Division of Cardiology.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Johnson
authors.affiliation: Division of Oncology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sulpher
authors.affiliation: Division of Cardiology.
authors.forename: Ellamae
authors.initials: E
authors.lastname: Stadnick