title: Accelerated pharmacokinetic map determination for dynamic contrast enhanced MRI using frequency-domain based Tofts model.
abstract: Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) is widely used in the diagnosis of cancer and is also a promising tool for monitoring tumor response to treatment. The Tofts model has become a standard for the analysis of DCE-MRI. The process of curve fitting employed in the Tofts equation to obtain the pharmacokinetic (PK) parameters is time-consuming for high resolution scans. Current work demonstrates a frequency-domain approach applied to the standard Tofts equation to speed-up the process of curve-fitting in order to obtain the pharmacokinetic parameters. The results obtained show that using the frequency domain approach, the process of curve fitting is computationally more efficient compared to the time-domain approach.
authors.forename: Nithin N
authors.initials: NN
authors.lastname: Vajuvalli
authors.forename: Krupa N
authors.initials: KN
authors.lastname: Nayak
authors.forename: Sairam
authors.initials: S
authors.lastname: Geethanath
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D019992:Databases as Topic; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis; D008962:Models, Theoretical; D051381:Rats; D013997:Time Factors
chemical_list: D003287:Contrast Media