title: Airway compromise due to adenoid cystic carcinoma obstructing the distal trachea: a review of current management and clinical trials.
abstract: An 84-year-old man presented with a 2-month history of intermittent stridor and worsening difficulty in breathing. Chest X-ray and flexible nasendoscopy were unremarkable but following further deterioration a CT scan revealed an obstructing lesion in the distal trachea. Bronchoscopy revealed an infiltrative tumour arising 3 cm above the carina causing 90% obstruction. The mass was biopsied and surgically debrided to leave a patent airway. Histological analysis revealed a diagnosis of adenoid cystic carcinoma. Transthoracic surgical resection was unsuccessful and the patient continues to be effectively managed with periodic bronchoscopic debulking and radiotherapy. This case highlights the diagnostic and therapeutic dilemmas posed by distal tracheal lesions and the need for specialist input for effective management.
authors.affiliation: Guy's and St Thomas' Hospital, London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Charlton
authors.affiliation: Royal Surrey County Hospital, Guildford, UK.
authors.forename: Lisa
authors.initials: L
authors.lastname: Pitkin
mesh_terms: D000369:Aged, 80 and over; D000402:Airway Obstruction / Q000209:etiology*; D001999:Bronchoscopy; D003528:Carcinoma, Adenoid Cystic / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003251:Constriction, Pathologic / Q000209:etiology; D006801:Humans; D008297:Male; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000473:pathology*; D014134:Tracheal Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome