title: Feasibility of measurement of bone turnover markers in female patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To investigate the feasibility of bone turnover markers (BTMs) for the assessment of bone metabolism in patients with systemic lupus erythematosus (SLE), according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine.
  
  
  METHODS
  The study included 43 female SLE patients. Serum procollagen type I N propeptide (PINP), C-terminal telopeptide of type I collagen (CTX), osteocalcin, PTH, 25(OH)D, anti-cardiolipin, anti-dsDNA, and anti-nucleosome levels were measured.
  
  
  RESULTS
  PINP and CTX levels were elevated in SLE patients aged > 45 in comparison to those aged < 45, although with borderline significance (p = 0.05, respectively). Correlations were found between BTMs: the strongest being between PINP and osteocalcin (τ = 0.69, p < 0.05). PINP and osteocalcin were found to be associated with PTH (τ = 0.3, τ = 0.29, respectively, p < 0.05). Age correlated with PINP (τ = 0.23, p < 0.05). Elevated PINP was found more frequently than elevated osteocalcin or CTX, both in patients aged < 45 (p = 0.001) and > 45 (p < 0.001). No significant difference in PINP, osteocalcin or CTX levels was found with respect to season, neither in the entire SLE group, nor in the under-45 or over-45 groups. Previous glucocorticoid treatment was not associated with difference in BTMs.
  
  
  CONCLUSIONS
  Increased BTMs in SLE appear to predominantly reflect the pattern of bone remodeling related to age. Increased PINP is expected to be the most frequent outcome among BTMs. Better diagnoses of bone disturbances with BTMs performed in accordance with international reference standards need to be included in the approach to SLE patients, in addition to bone mineral density assessment.
authors.affiliation: Departamento de Dermatologia e Venereologia, Medical University of Lodz, Lodz, Polônia. Electronic address: jaroslaw.bogaczewicz@umed.lodz.pl.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Bogaczewicz
authors.affiliation: Departamento de Bioquímica, Radioimunologia e Medicina Experimental, The Children's Memorial Health Institute, Varsóvia, Polônia.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Karczmarewicz
authors.affiliation: Departamento de Bioquímica, Radioimunologia e Medicina Experimental, The Children's Memorial Health Institute, Varsóvia, Polônia.
authors.forename: Pawel
authors.initials: P
authors.lastname: Pludowski
authors.affiliation: Departamento de Microbiologia e Sorologia, Instituto de Reumatologia, Varsóvia, Polônia.
authors.forename: Jakub
authors.initials: J
authors.lastname: Zabek
authors.affiliation: Departamento de Medicina Interna e Reabilitação Cardíaca, Medical University of Lodz, Lodz, Polônia.
authors.forename: Jan
authors.initials: J
authors.lastname: Kowalski
authors.affiliation: Departamento de Bioquímica e Química Clínica, Faculdade de Farmácia, Medical University of Warsaw, Varsóvia, Polônia.
authors.forename: Jacek
authors.initials: J
authors.lastname: Lukaszkiewicz
authors.affiliation: Departamento de Dermatologia e Venereologia, Medical University of Lodz, Lodz, Polônia.
authors.forename: Anna
authors.initials: A
authors.lastname: Wozniacka
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D015415:Biomarkers
keywords: Bone turnover; Lúpus eritematoso sistêmico; Osteocalcin; Osteocalcina; Procollagen; Procolágeno; Remodelação óssea; Systemic lupus erythematosus; Vitamin D; Vitamina D