title: Study on application of ultrasound microbubbles in the diagnosis of buccal carcinoma and metastatic cervical lymph nodes in mice.
abstract: BACKGROUND
  This project's aim was to explore the enhancing effect of contrast media on primary cancer and cervical metastatic lymph nodes of cheek carcinoma by local injection.
  
  
  METHODS
  Lymphatic metastasis cheek carcinoma mice models were established, then self-made contrast media was administered into the primary cheek carcinoma and harmonic mode imaging was performed to observe the enhancement of primary lesions and cervical metastatic lymph nodes.
  
  
  RESULTS
  The echo intensity (EI) was compared. The detection rate of metastatic lymph nodes and inflammatory lymph nodes was 61% (17/28) and 50% (6/12) before contrast-enhanced ultrasound (CEUS) imaging and 82% (23/28) and 75% (9/12) after CEUS imaging. After CEUS imaging, the EI of primary cancer and cervical metastatic lymph nodes was significantly increased, (P<0.01).
  
  
  CONCLUSIONS
  After injection of self-made contrast media via the primary lesion, it can enter the lymph duct and obviously enhance the effect of ultrasonography on cervical metastatic lymph nodes of cheek carcinoma.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Pang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Gao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.forename: Guijie
authors.initials: G
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Stomatology; Chongqing Research Center for Oral Diseases and Biomedical Science, Chongqing Medical University, Chongqing, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Qiu
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging*; D002610:Cheek / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry; D007249:Inflammation / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D045423:Microbubbles; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D009362:Neoplasm Metastasis; D013696:Temperature; D014463:Ultrasonography
chemical_list: D003287:Contrast Media