title: Ang (1-7) is a modulator of the vasoconstrictor actions of Ang I and Ang II.
abstract: BACKGROUND
  The role of angiotensin (Ang) (1-7) on the vasoconstrictor effect induced by angiotensins could be different in the presence of an ACE inhibitor or an ARB because Ang II is formed through several pathways. Therefore, the role of Ang (1-7) in Ang I and Ang II contraction was evaluated in aortas from Wistar rats after 48-hour coronary occlusion treated with captopril or losartan.
  
  
  METHODS
  Concentration-response curves to Ang I or Ang II were conducted in the absence or presence of Ang (1-7) and A779: a) sham group; b) 48-hour coronary occlusion; c) treated with captopril or d) losartan (3.1 mg/kg, i.m.).
  
  
  RESULTS
  Captopril caused a significant increase in the contractile effect of Ang I and Ang II, while losartan reduced it. The presence of Ang (1-7) in the captopril group showed a reduction of the contraction compared to the sham group, while the treatment with losartan did not show a significant difference. Ang (1-7) presents effects different from Ang I or Ang II.
  
  
  CONCLUSIONS
  Ang (1-7) showed a modulatory role, suggesting Ang I did as well after treatment with an ACE inhibitor but not with an AT1 receptor antagonist.
authors.affiliation: Laboratorio de Farmacología del Miocardio, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónioma de México, Mexico Laboratorio de Farmacodinamia, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
authors.forename: Jazmín
authors.initials: J
authors.lastname: Flores-Monroy
authors.affiliation: Laboratorio de Farmacodinamia, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Valencia-Hernández
authors.affiliation: Laboratorio de Farmacología del Miocardio, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónioma de México, Mexico farma2008_1@yahoo.com.mx.
authors.forename: Luisa
authors.initials: L
authors.lastname: Martínez-Aguilar
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology*; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: Angiotensin (1–7); angiotensin I; myocardial infarction