title: Duodenal Neuroendocrine Carcinoma Presenting with Disseminated Liver and Bone Metastases as the Primary Manifestation: Case Report and Literature Review.
abstract: Neuroendocrine tumors are composed by a heterogeneous group of tumors with a wide range of morphologic, functional, and behavioral characteristics. These tumors are generally slow growing and behave in an indolent fashion. However, they have the potential to spread, especially for poorly differentiated neuroendocrine carcinomas, and when they do, they can be very aggressive, with high propensity for distant metastases, and difficult to treat with current modalities. As poorly differentiated neuroendocrine carcinomas rarely occur in extrapulmonary sites, to the best of our knowledge, this is the first case report of a poorly differentiated duodenal neuroendocrine carcinoma with diffuse liver and bone metastases as the primary manifestation. Despite receiving a trial of chemotherapeutic regimen, the patient had progressive intrahepatic cholestasis and died of subacute hepatic failure.
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. taoguo2077@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, Centro Hospitalar Conde de S. Januario (CHCSJ), Macao, China.
authors.forename: Ka Kei
authors.initials: KK
authors.lastname: Ng
authors.affiliation: Department of Gastroenterology, Centro Hospitalar Conde de S. Januario (CHCSJ), Macao, China.
authors.forename: Hoi Wan
authors.initials: HW
authors.lastname: Chiang
authors.affiliation: Department of Gastroenterology, Centro Hospitalar Conde de S. Januario (CHCSJ), Macao, China.
authors.forename: Man Fei
authors.initials: MF
authors.lastname: Ma
authors.affiliation: Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
authors.forename: Jia Ming
authors.initials: JM
authors.lastname: Qian
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D002780:Cholestasis, Intrahepatic / Q000378:metabolism / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D017093:Liver Failure / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology; D016896:Treatment Outcome
keywords: Bone metastases; Duodenum; Liver metastases; Neuroendocrine carcinoma; Poor differentiation