title: Hemostatic action of EGF-endospray on mucosectomy-induced ulcer bleeding animal models.
abstract: Gastric bleeding is one of the irritant problems in ulcer patients. In this study, we evaluated hemostatic action of ulcer-coating powder (EGF-endospray) on gastric ulcer animal models. EGF-endospray, containing epidermal growth factor, is designed to be applied through an endoscope. Hemostatic action of the EGF-endospray was evaluated on gastric hemorrhage models of rabbits and micro-pigs. The EGF-endospray was directly applied onto a mucosal resection (MR)-induced gastric bleeding focus in a rabbit model. In a porcine model, the EGF-endospray was applied once via an endoscopy to a bleeding lesion created by endoscopic submucosal dissection. The bleeding focus was then observed via an endoscope. In the rabbit model, EGF-endospray treatment significantly shortened mean bleeding time in comparison with other treatments (104.3 vs 548.0 vs 393.2 s for the EGF-endospray, the non-treated control and the epinephrine injection, respectively). In the micro-pig model, EGF-endospray showed immediate hemostatic action and prolonged covering of the bleeding focus for over 72 h. Histology proved mucosal thickness was more efficiently recovered in all EGF-endospray treated animals. The results of the present study suggest that the EGF-endospray is a promising hemostatic agent for GI bleeding.
authors.affiliation: Division of Gastroenterology & Hepatology, Inha University Hospital, Incheon, South Korea.
authors.forename: Byoung Wook
authors.initials: BW
authors.lastname: Bang
authors.affiliation: Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, South Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Maeng
authors.affiliation: Department of New Drug Development and NCEED, School of Medicine, Inha University, Incheon, South Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Division of Gastroenterology & Hepatology, Inha University Hospital, Incheon, South Korea Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, South Korea.
authors.forename: Don Haeng
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of New Drug Development and NCEED, School of Medicine, Inha University, Incheon, South Korea.
authors.forename: Su-Geun
authors.initials: SG
authors.lastname: Yang
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004815:Epidermal Growth Factor / Q000737:chemistry; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006470:Hemorrhage / Q000188:drug therapy*; D006487:Hemostasis; D006490:Hemostatics / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D023421:Models, Animal; D009092:Mucous Membrane / Q000473:pathology*; D011208:Powders; D011817:Rabbits; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D006490:Hemostatics; D020100:Hydrogels; D011208:Powders; D004815:Epidermal Growth Factor
keywords: Gastric bleeding; endoscopy; epidermal growth factor; hemostatic powder