title: L-Arginine and vascular diseases: lights and pitfalls!
abstract: L-Arginine, a semi-essential cationic amino acid involved in multiple areas of human physiology and metabolism, is a precursor of nitric oxide, and, recently, it has been found to crucially influence endothelial function. Arginine appears to be safe and effective therapy for many health conditions, particularly vascular diseases responsive to modulation of endothelial-derived relaxing factor including intermittent claudication, angina pectoris and erectile dysfunction. However, L-arginine metabolism is still not fully understood, highlighting a complex implication for its pharmacological use in clinical practice. In this review, we want to point out the lights and pitfalls of L-arginine as potential therapeutic option in vascular disorders.
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo". salbro77@tiscali.it.
authors.forename: Rocco Salvatore
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gervasi
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D001120:Arginine / Q000378:metabolism*; D006801:Humans; D014652:Vascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism
chemical_list: D001120:Arginine