title: The influence of deltalycyn and transcranial cerebellar stimulation upon recovery of retina after photo stress in patients with diabetic retinopathy.
abstract: OBJECTIVE
  The characteristics of visual evoked potentials (VEP) have been studied in diabetic patients with and without diabetic retinopathy.
  
  
  METHODS
  Magnetic impulses (2.0 T1 at the height of impulse) have been delivered to the cerebellar surface transcranially using the "Neuro-MS/D", (Russia Federation). Delta- sleep inducing peptide ("Deltalycyn", "Biopharma", Russia Federation) was intranasally delivered in 30 min before photostress. Afterwards VEP have been registered every 20 s from the moment of photo stress during one minute.
  
  
  RESULTS
  An increase of the latency period and a reduction of the VEP amplitude have been recorded in the period following photo stress exposure of the macular part of the retina. The VEP characteristics restored to the initial level in 73.5 +/- 3.3 s from the photo stress moment in the control group; while in diabetic patients with retinopathy this index was 137.2 +/- 11.3 s. In the. presence of cerebellar transcranial magnetic stimulations (2.0 T1, 20 impulses) the VEP amplitude depression was less pro- nounced, and the restoration period of the VEP characteristics shortened to 110.3+ 12.7 s, while in deltalycyn treated patients restoration was observed in 95.1+ 6.8 s. Under condition of combined usage of deltalycyn and TMS period of restoration of VEP was shortened up to 82.5 +/- 6.5 s.
  
  
  CONCLUSIONS
  Retinopathy development is linked to prolonged VEP latency period (P100), lowering of the N75-P100 amplitude, as well as to enlargement of the recovery period of the retina's functional capacity in patients suffering from the diabetes mellitus in the presence of photo stress. Superlatively administered deltalycyn and cerebellar transcranial magnetic stimulation facilitates a faster recovery of the retina's functional capacity in response to photo stress in diabetic patients with retinopathy. 3. Combined usage of deltalycyn and cerebellar transcranial stimulation caused the potentiated shortening of post-photo stress recovering of VEP in patients with diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Odessa National Medical University, Odessa, Ukraine.
authors.forename: Nataliya Valentinivna
authors.initials: NV
authors.lastname: Kresyun
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D016022:Case-Control Studies; D002531:Cerebellum / Q000503:physiopathology; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage* / Q000627:therapeutic use; D003930:Diabetic Retinopathy / Q000503:physiopathology* / Q000628:therapy*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D010775:Photic Stimulation / Q000379:methods; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide