title: Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages.
abstract: Macrophages represent a class of cells specialized for phagocytosis that occurs in multiple, phenotypically distinct populations throughout the body. Two studies published in Cell demonstrate that these phenotypic differences reflect drastic differences in the populations of enhancers that regulate transcription, and that this epigenomic diversity is, in fact, highly plastic and sensitive to environmental cues.
authors.affiliation: Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA. Electronic address: michael_bulger@urmc.rochester.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Bulger
authors.affiliation: Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA.
authors.forename: James
authors.initials: J
authors.lastname: Palis
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D005260:Female; D006657:Histones / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male
chemical_list: D006657:Histones
keywords: cellular plasticity; enhancers; histone modification; macrophages; transcription factors