title: [Correlation between quantitative results of contrast-enhanced ultrasonography and clinical and laboratory indexes for synovium of patients with rheumatoid arthritis ].
abstract: OBJECTIVE
  To determine the correlation between quantitative results of contrast enhanced ultrasound and clinical and laboratory index for synovium of patients with rheumatoid arthritis (RA).
  
  
  METHODS
  Thirty five RA patients participated in this study, with ten normal adults serving as controls. They were given a score of DAS28 and underwent laboratory tests, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Contrast-enhanced ultrasound examinations were performed to detect thickness of synovium (2D and Power Dopple).
  
  
  RESULTS
  Peak intensity (PI) and area under the curve (AUC) were positively correlated with ESR, CRP and DAS28 score, respectively (P<0. 01). The rest of ultrasound parameters had no significant correlations with ESR, CRP and DAS28 score (P>0. 05). Synovium thickness identified by contrast enhanced ultrasound had significant correlations with ESR, CRP and DAS28 score (P < 0. 01).
  
  
  CONCLUSIONS
  Synovium thickness determined by contrast enhanced ultrasound, PI and AUC can serve as an index estimating inflammatory activity of RA, and provide evidence for clinical diagnosis and treatment.
authors.affiliation: Department of Ultrasound,  West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ling-yan
authors.initials: LY
authors.lastname: Zhang
authors.forename: Xi
authors.initials: X
authors.lastname: Xiang
authors.forename: Yuan-jiao
authors.initials: YJ
authors.lastname: Tang
authors.forename: Qian-ying
authors.initials: QY
authors.lastname: Leng
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D006801:Humans; D012720:Severity of Illness Index; D013583:Synovial Membrane / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D002097:C-Reactive Protein