title: Update on Huntington's disease: advances in care and emerging therapeutic options.
abstract: BACKGROUND
  Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that both the gene and the mutation causing this monogenetic disorder were identified more than 20 years ago, disease-modifying therapies for HD have not yet been established.
  
  
  METHODS
  While intense preclinical research and large cohort studies in HD have laid foundations for tangible improvements in understanding HD and caring for HD patients, identifying targets for therapeutic interventions and developing novel therapeutic modalities (new chemical entities and advanced therapies using DNA and RNA molecules as therapeutic agents) continues to be an ongoing process. The authors review recent achievements in HD research and focus on approaches towards disease-modifying therapies, ranging from huntingtin-lowering strategies to improving huntingtin clearance that may be promoted by posttranslational HTT modifications.
  
  
  CONCLUSIONS
  The nature and number of upcoming clinical studies/trials in HD is a reason for hope for HD patients and their families.
authors.affiliation: Department of Social Medicine, Poznan University of Medical Sciences, Poland. Electronic address: daniel.zielonka@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zielonka
authors.affiliation: Department of Medical and Molecular Genetics, King's College London, London, UK.
authors.forename: Michal
authors.initials: M
authors.lastname: Mielcarek
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany.
authors.forename: G Bernhard
authors.initials: GB
authors.lastname: Landwehrmeyer
mesh_terms: D002986:Clinical Trials as Topic; D004638:Emergency Treatment / Q000379:methods*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000628:therapy*; D010166:Palliative Care
keywords: Disease-modifying treatment; Experimental medicine; Huntington's disease; Symptomatic relief; Therapy