title: Photothermal cancer therapy using graphitic carbon-coated magnetic particles prepared by one-pot synthesis.
abstract: We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriaminepentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm(-2)). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method.
authors.affiliation: Nano and Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Hyo-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Jakkid
authors.initials: J
authors.lastname: Sanetuntikul
authors.affiliation: Nano and Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Choi
authors.affiliation: Nano and Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Bo Ram
authors.initials: BR
authors.lastname: Lee
authors.affiliation: Nano and Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Nano and Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
authors.forename: Sangaraju
authors.initials: S
authors.lastname: Shanmugam
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D055598:Chemical Phenomena; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007501:Iron / Q000737:chemistry; D008027:Light; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000628:therapy*; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared; D023041:Xenograft Model Antitumor Assays
chemical_list: D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; C000499:ferric oxide; D002244:Carbon; D007501:Iron
keywords: graphitic carbon–encapsulated magnetic nanoparticles; iron oxide; one-pot synthesis; photothermal cancer therapy