title: Mixed zirconia calcium phosphate coatings for dental implants: tailoring coating stability and bioactivity potential.
abstract: Enhanced coating stability and adhesion are essential for long-term success of orthopedic and dental implants. In this study, the effect of coating composition on mechanical, physico-chemical and biological properties of coated zirconia specimens is investigated. Zirconia discs and dental screw implants are coated using the wet powder spraying (WPS) technique. The coatings are obtained by mixing yttria-stabilized zirconia (TZ) and hydroxyapatite (HA) in various ratios while a pure HA coating served as reference material. Scanning electron microscopy (SEM) and optical profilometer analysis confirm a similar coating morphology and roughness for all studied coatings, whereas the coating stability can be tailored with composition and is probed by insertion and dissections experiments in bovine bone with coated zirconia screw implants. An increasing content of calcium phosphate (CP) resulted in a decrease of mechanical and chemical stability, while the bioactivity increased in simulated body fluid (SBF). In vitro experiments with human osteoblast cells (HOB) revealed that the cells grew well on all samples but are affected by dissolution behavior of the studied coatings. This work demonstrates the overall good mechanical strength, the excellent interfacial bonding and the bioactivity potential of coatings with higher TZ contents, which provide a highly interesting coating for dental implants.
authors.affiliation: University of Bremen, Advanced Ceramics, Am Biologischen Garten 2, 28359 Bremen, Germany.
authors.forename: Karoline
authors.initials: K
authors.lastname: Pardun
authors.affiliation: University of Bremen, Advanced Ceramics, Am Biologischen Garten 2, 28359 Bremen, Germany. Electronic address: treccani@uni-bremen.de.
authors.forename: Laura
authors.initials: L
authors.lastname: Treccani
authors.affiliation: University of Bremen, Advanced Ceramics, Am Biologischen Garten 2, 28359 Bremen, Germany.
authors.forename: Eike
authors.initials: E
authors.lastname: Volkmann
authors.affiliation: University Hospital, Justus-Liebig-University Giessen, Department of Cranio-Maxillo-Facial Surgery, Klinikstrasse 33, 35385 Giessen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Streckbein
authors.affiliation: University Hospital of Giessen-Marburg, Department of Trauma Surgery, Rudolf-Buchheim-Strasse 7, 35385 Giessen, Germany,; Laboratory of Experimental Surgery, Kerkraderstrasse 9, 35392 Giessen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Heiss
authors.affiliation: Laboratory for Molecular Surfaces and Nanotechnology (LAMSUN), Department of Chemistry, University of Catania and CSGI, Viale A. Doria 6, 95125 Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Li Destri
authors.affiliation: Laboratory for Molecular Surfaces and Nanotechnology (LAMSUN), Department of Chemistry, University of Catania and CSGI, Viale A. Doria 6, 95125 Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marletta
authors.affiliation: University of Bremen, Advanced Ceramics, Am Biologischen Garten 2, 28359 Bremen, Germany.
authors.forename: Kurosch
authors.initials: K
authors.lastname: Rezwan
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D006801:Humans; D008422:Materials Testing; D015040:Zirconium / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; C020243:calcium phosphate; D015040:Zirconium; C028541:zirconium oxide
keywords: Bioactivity; Calcium phosphate; Cellular biocompatibility; Coating stability; Dissolution; Zirconia