title: Symphonia globulifera, a widespread source of complex metabolites with potent biological activities.
abstract: Symphonia globulifera has been widely used in traditional medicine and has therefore been subjected to several phytochemical studies in the American and African continents. Interestingly, some disparities have been observed concerning its metabolic profile. Several phytochemical studies of S. globulifera have led to the identification of more than 40 compounds, including several polycyclic polyprenylated acylphloroglucinols. Biological evaluations have pointed out the promising biological activities of these secondary metabolites, mostly as antiparasitic or antimicrobial, confirming the traditional use of this plant. The purpose of this review is to describe the natural occurrence, botanical aspects, ethnomedicinal use, structure, and biogenesis, as well as biological activities of compounds isolated from this species according to their provenance.
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Fromentin
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Cottet
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Marina
authors.initials: M
authors.lastname: Kritsanida
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gaboriaud-Kolar
authors.affiliation: Laboratoire de Pharmacognosie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lallemand
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053898:Biosynthetic Pathways; D028084:Clusiaceae / Q000737:chemistry*; D008519:Medicine, Traditional; D055432:Metabolomics; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D064210:Secondary Metabolism
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts