title: Long-term survival in a case of pleomorphic carcinoma with a brain metastasis.
abstract: Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the case of a patient with PC and a single brain metastasis that achieved long-term recurrence-free survival following treatment with combined modality therapy. In this case, the MIB-1 index was reduced by gemcitabine-based chemotherapy, which may have led to long-term disease-free survival. The MIB-1 index may be a useful biomarker for the response to chemotherapy.
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Yamanashi
authors.affiliation: Respiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Marumo
authors.affiliation: Department of Thoracic Surgery, Kishiwada City Hospital, Kishiwada, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Miura
authors.affiliation: Department of Thoracic Surgery, Kishiwada City Hospital, Kishiwada, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kawashima
keywords: Adjuvant/neoadjuvant therapy; Lung cancer surgery; Metastases