title: Bioactive fused heterocycles: Nucleoside analogs with an additional ring.
abstract: The following mini-review summarizes the basic literature data regarding synthesis, biological activity, structure-activity relationship, and discussion of the mechanisms of action of two major classes of nucleoside analogs with fused heterocyclic rings: (i) the ethenonucleosides and their related derivatives of the 5,9-dihydro-3-glycosyl-6-alkyl-9-oxo-5H-imidazo[1,2-a]purine type; (ii) the bicyclic nucleosides of 6-alkyl-2,3-dihydrofurano[2,3-d]-pyrimidin-2(3H)-one and 6-alkyl-2,3-dihydropyrrolo[2,3-d]-pyrimidin-2(3H,7H)-one.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Science, Z. Noskowskiego 12/14, PL-61704, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Jahnz-Wechmann
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Science, Z. Noskowskiego 12/14, PL-61704, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Framski
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Science, Z. Noskowskiego 12/14, PL-61704, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Januszczyk
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Science, Z. Noskowskiego 12/14, PL-61704, Poland. Electronic address: jboryski@ibch.poznan.pl.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Boryski
mesh_terms: D000818:Animals; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D006571:Heterocyclic Compounds; D009705:Nucleosides
keywords: Antiviral activity; Bioactive nucleosides; Ethenonucleosides; Furano[2,3-d]pyrimidine nucleosides; Fused heterocycles; Pyrrolo[2,3-d]pyrimidine nucleosides