title: [Nosocomial infection due to Trichosporon asahii in a critical burned patient].
abstract: BACKGROUND
  Invasive fungal infection is an important cause of morbimortality in patients with severe burns. The advances in burn care therapy have considerably extended the survival of seriously burned patients, exposing them to infectious complications, notably fungal infections, with increased recognition of invasive infections caused by Candida species. However, some opportunistic fungi, like Trichosporon asahii, have emerged as important causes of nosocomial infection.
  
  
  METHODS
  A case of nosocomial infection due to T. asahii in a severely ill burned patient successfully treated with voriconazole is presented. The management of invasive fungal infections in burned patients, from diagnosis to selection of the therapeutic protocol, is often a challenge. Early diagnosis and treatment are associated with a better prognosis. In this case report, current treatment options are discussed, and a review of previously published cases is presented.
  
  
  CONCLUSIONS
  Due to the difficulty in the diagnosis of invasive mycoses and their high associated mortality rates, it is advisable to keep a high degree of clinical suspicion of trichosporonosis in susceptible patients, including burned patients. The isolation of T. asahii in clinical specimens of this type of host must raise clinical alert, since it may precede an invasive infection.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Río Hortega, Valladolid, España. Electronic address: luistalo@hotmail.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Tamayo Lomas
authors.affiliation: Servicio de Microbiología, Hospital Universitario Río Hortega, Valladolid, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Domínguez-Gil González
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Río Hortega, Valladolid, España.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Martín Luengo
authors.affiliation: Servicio de Microbiología, Hospital Universitario Río Hortega, Valladolid, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Eiros Bouza
authors.affiliation: Servicio de Cirugía Plástica, Hospital Universitario Río Hortega, Valladolid, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Piqueras Pérez
mesh_terms: D000062:Accidents, Occupational; D000935:Antifungal Agents / Q000627:therapeutic use; D002056:Burns / Q000150:complications* / Q000382:microbiology; D002177:Candidiasis / Q000150:complications; D000077336:Caspofungin; D002405:Catheterization, Central Venous; D060085:Coinfection; D003428:Cross Infection / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D004431:Ear, External / Q000293:injuries / Q000382:microbiology; D054714:Echinocandins / Q000627:therapeutic use; D004756:Enterobacteriaceae Infections / Q000150:complications; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides; D008875:Middle Aged; D020613:Morganella morganii / Q000302:isolation & purification; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D012121:Respiration, Artificial; D012772:Shock, Septic / Q000209:etiology; D014250:Trichosporon / Q000302:isolation & purification*; D060586:Trichosporonosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D065819:Voriconazole / Q000627:therapeutic use; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin; D065819:Voriconazole
keywords: Antifungals; Antifúngicos; Burned; Critically ill patient; Emergent pathogen; Paciente crítico; Patógeno emergente; Quemado; Trichosporon asahii; Trichosporonosis