title: Bradykinin B2 receptor antagonist off label use in short-term prophylaxis in hereditary angioedema.
abstract: Hereditary angioedema type I (HAE-C1-INH) is an inherited disorder characterized by repeated severe angioedema attacks mostly triggered by traumas, emotional stress, increased estrogen levels or surgical procedures, in particular, odontostomatological interventions. Icatibant, a bradykinin B2 receptor antagonist, has been approved for treatment of HAE attacks. In this paper we describe the off label administration of icatibant as short-term prophylaxis of dental extraction in a patient with HAE with the aim of preventing perioperative angioedema attacks. The drug showed an effective and safe profile. Thus, a short-term prophylaxis of angioedema attacks in patients with HAE may be arranged on a multidisciplinary basis, according to the clinical history of each single patients.
authors.affiliation: Anesthesiology and Pain Medicine, Department of Life, Health and Environmental Sciences, University of LAquila, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Angeletti
authors.affiliation: Anesthesiology and Pain Medicine, Department of Life, Health and Environmental Sciences, University of LAquila, Italy.
authors.forename: P M
authors.initials: PM
authors.lastname: Angeletti
authors.affiliation: Anesthesiology and Pain Medicine, Department of Life, Health and Environmental Sciences, University of LAquila, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mastrobuono
authors.affiliation: Operative Unit of Anesthesiology, Intensive Care and Pain Medicine, Civil Hospital G. Mazzini of Teramo, Teramo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pilotti
authors.affiliation: Anesthesiology and Pain Medicine, Department of Life, Health and Environmental Sciences, University of LAquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ciccozzi
authors.affiliation: Anesthesiology and Pain Medicine, Department of Life, Health and Environmental Sciences, University of LAquila, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Guetti
mesh_terms: D054179:Angioedemas, Hereditary / Q000517:prevention & control*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065094:Bradykinin B2 Receptor Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D056687:Off-Label Use
chemical_list: D065094:Bradykinin B2 Receptor Antagonists; C065679:icatibant; D001920:Bradykinin