title: Serum docosahexaenoic acid (DHA) is inversely associated with anxiety disorders in early pregnancy.
abstract: Little is known about the association between polyunsaturated fatty acids (PUFAs) and anxiety disorders during pregnancy. We evaluated this association at the first pregnancy trimester in 228 women. The study endpoint was the diagnosis of any anxiety disorder assessed by the Mini International Neuropsychiatric Interview. The independent variables were the serum concentrations of total n-3 and fractions (18:2, 20:5, 22:5, 22:6), total n-6 and fractions (18:2, 18:3, 20:2, 20:3, 20:4, 22:4, 22:5) and the n-6/n-3 ratio PUFAs. The prevalence of any anxiety disorders was 25%. The first tertile of the docosahexaenoic acid (DHA, 22:6 n-3) distribution represented 1.95 (95% CI: 1.00-3.77) higher chance of having an anxiety disorder diagnosis, compared to those in the second and third tertiles after adjusting the analyses for parity, family income, early pregnancy BMI and gestational age at the blood sampling. Serum concentrations of DHA were inversely associated with the occurrence of early pregnancy anxiety disorders.
authors.affiliation: Institute of Psychology, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Marcus Vinícius Barbosa
authors.initials: MV
authors.lastname: Verly-Miguel
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil; Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Dayana Rodrigues
authors.initials: DR
authors.lastname: Farias
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil; Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Thatiana de Jesus Pereira
authors.initials: Tde J
authors.lastname: Pinto
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil; Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Lepsch
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, School of Medicine, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Antonio Egidio
authors.initials: AE
authors.lastname: Nardi
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: gilberto.kac@gmail.com.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Kac
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood / Q000209:etiology*; D003430:Cross-Sectional Studies; D004281:Docosahexaenoic Acids / Q000097:blood; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000209:etiology*; D011261:Pregnancy Trimester, First; D055815:Young Adult
chemical_list: D043371:Fatty Acids, Omega-6; D004281:Docosahexaenoic Acids
keywords: Anxiety disorders; Docosahexaenoic acid; Essential fatty acids; Pregnancy