title: [Clinical and analytical toxicology of opiate, cocaine and amphetamine].
abstract: In several circumstances, determination and quantification of illicit drugs in biological fluids are determinant. Contexts are varied such as driving under influence, traffic accident, clinical and forensic toxicology, doping analysis, chemical submission. Whole blood is the favoured matrix for the quantification of illicit drugs. Gas chromatography coupled with mass spectrometry (GC-MS) is the gold standard for these analyses. All methods developed must be at least equivalent to gas chromatography coupled with a mass spectrometer. Nowadays, new technologies are available to biologists and clinicians: liquid chromatography coupled with a mass spectrometry (LC/MS) or coupled with a tandem mass spectrometer (LC/MS/MS). The aim of this paper is to describe the state of the art regarding techniques of confirmation by mass spectrometry used for quantification of conventional drugs except cannabis.
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Feliu
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Fouley
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Millart
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Gozalo
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Marty
authors.affiliation: Laboratoire de pharmacologie et toxicologie, CHU de Reims, Reims, France.
authors.forename: Zoubir
authors.initials: Z
authors.lastname: Djerada
mesh_terms: D000661:Amphetamine / Q000032:analysis* / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods; D002853:Chromatography, Liquid; D003042:Cocaine / Q000032:analysis* / Q000097:blood; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis* / Q000097:blood; D009294:Narcotics / Q000032:analysis* / Q000097:blood; D015813:Substance Abuse Detection / Q000379:methods*; D053719:Tandem Mass Spectrometry; D014116:Toxicology / Q000379:methods*
chemical_list: D013287:Illicit Drugs; D009294:Narcotics; D000661:Amphetamine; D003042:Cocaine
keywords: blood; drug abuse; gas chromatography; liquid chromatography; mass spectrometry