title: Association of polymorphisms of genes involved in lipid metabolism with blood pressure and lipid values in mexican hypertensive individuals.
abstract: Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5 rs3135506, APOB rs1042031, FABP2 rs1799883, LDLR rs5925, LIPC rs1800588, LPL rs328, and MTTP rs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients. A total of 160 HT patients and 160 normotensive individuals were included. Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing. The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic. The alleles FABP2 p.55T, LIPC -514T, and MTTP -493T were associated with elevated systolic BP. Five alleles were associated with lipids. LPL p.474X and FABP2 p.55T were associated with decreased total cholesterol and LDL-C, respectively; APOA5 p.19W with increased HDL-C; APOA5 p.19W and FABP2 p.55T with increased triglycerides; and APOB p.4181K and LDLR c.1959T with decreased triglycerides. The APOB p.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17-2.93; P = 0.001) under the dominant model. These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44348 Guadalajara, JAL, Mexico.
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: Ríos-González
authors.affiliation: Instituto de Genética Humana "Enrique Corona Rivera", Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44348 Guadalajara, JAL, Mexico.
authors.forename: Bertha
authors.initials: B
authors.lastname: Ibarra-Cortés
authors.affiliation: Unidad de Investigación Epidemiológica y en Servicios de Salud del Adolescente, Instituto Mexicano del Seguro Social, Avenida Tonalá 121, 45400 Tonalá, JAL, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ramírez-López
authors.affiliation: División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Sánchez-Corona
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Magaña-Torres
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053299:Apolipoprotein B-100 / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D050556:Fatty Acid-Binding Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D008049:Lipase / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011973:Receptors, LDL / Q000235:genetics; D055815:Young Adult
chemical_list: C569471:APOB protein, human; D053299:Apolipoprotein B-100; D002352:Carrier Proteins; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; C573412:LDLR protein, human; C504173:LIPC protein, human; D008055:Lipids; D011973:Receptors, LDL; C106092:microsomal triglyceride transfer protein; D008049:Lipase