title: Reputation-based collaborative network biology.
abstract: A pilot reputation-based collaborative network biology platform, Bionet, was developed for use in the sbv IMPROVER Network Verification Challenge to verify and enhance previously developed networks describing key aspects of lung biology. Bionet was successful in capturing a more comprehensive view of the biology associated with each network using the collective intelligence and knowledge of the crowd. One key learning point from the pilot was that using a standardized biological knowledge representation language such as BEL is critical to the success of a collaborative network biology platform. Overall, Bionet demonstrated that this approach to collaborative network biology is highly viable. Improving this platform for de novo creation of biological networks and network curation with the suggested enhancements for scalability will serve both academic and industry systems biology communities.
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Jean
authors.initials: J
authors.lastname: Binder
authors.forename: Stephanie
authors.initials: S
authors.lastname: Boue
authors.forename: Anselmo
authors.initials: A
authors.lastname: Di Fabio
authors.forename: R Brett
authors.initials: RB
authors.lastname: Fields
authors.forename: William
authors.initials: W
authors.lastname: Hayes
authors.forename: Julia
authors.initials: J
authors.lastname: Hoeng
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Park
authors.forename: Manuel C
authors.initials: MC
authors.lastname: Peitsch
mesh_terms: D019295:Computational Biology; D003299:Cooperative Behavior; D063045:Crowdsourcing / Q000706:statistics & numerical data; D006801:Humans; D020407:Internet; D008168:Lung / Q000502:physiology; D008954:Models, Biological; D010865:Pilot Projects; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D049490:Systems Biology