title: Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT.
abstract: This paper presents a handheld micro-injector system using common-path swept source optical coherence tomography (CP-SSOCT) as a distal sensor with highly accurate injection-depth-locking. To achieve real-time, highly precise, and intuitive freehand control, the system used graphics processing unit (GPU) to process the oversampled OCT signal with high throughput and a smart customized motion monitoring control algorithm. A performance evaluation was conducted with 60-insertions and fluorescein dye injection tests to show how accurately the system can guide the needle and lock to the target depth. The evaluation tests show our system can guide the injection needle into the desired depth with 4.12 um average deviation error while injecting 50 nl of fluorescein dye.
authors.forename: Gyeong Woo
authors.initials: GW
authors.lastname: Cheon
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Hye Rin
authors.initials: HR
authors.lastname: Kwag
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Kim
authors.forename: Russell H
authors.initials: RH
authors.lastname: Taylor
authors.forename: Peter L
authors.initials: PL
authors.lastname: Gehlbach
authors.forename: Jin U
authors.initials: JU
authors.lastname: Kang
mesh_terms: D004396:Coloring Agents / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D008845:Microinjections / Q000295:instrumentation*; D059629:Signal-To-Noise Ratio; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents; D005780:Gelatin