title: Synthesis of enantioenriched 5,6-dihydrophenanthridine derivatives through retro-carbopalladation of chiral o-bromobenzylamines.
abstract: Retro-carbopalladation of aldimines in the presence of a suitable β-hydrogen atom has been observed in the Pd-catalyzed homocoupling reactions of o-bromobenzylamines, providing an expeditious synthetic route to 5,6-dihydrophenanthridine derivatives. Furthermore, a highly enantioselective synthesis of 6-aryl-substituted 5,6-dihydrophenanthridines was achieved in a one-pot manner by taking advantage of Rh and Pd catalysis.
authors.affiliation: Davenport Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6 (Canada).
authors.forename: Juntao
authors.initials: J
authors.lastname: Ye
authors.forename: Aurore
authors.initials: A
authors.lastname: Limouni
authors.forename: Sonia
authors.initials: S
authors.lastname: Zaichuk
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
keywords: dihydrophenanthridines; enantioselective synthesis; palladium; β-carbon elimination