title: New-onset atrial fibrillation in sepsis is associated with increased morbidity and mortality.
abstract: BACKGROUND
  The development of new-onset atrial fibrillation in sepsis has been associated with adverse outcomes.
  
  
  METHODS
  A systematic literature search was conducted to retrieve articles that investigated the association of new-onset atrial fibrillation in patients diagnosed with sepsis. The primary outcome of interest was the pooled risk ratio (RR) of in-hospital mortality in patients with new-onset atrial fibrillation and sepsis.
  
  
  RESULTS
  Six studies included 3100 patients with new-onset atrial fibrillation in sepsis and 36,900 patients without new-onset atrial fibrillation in sepsis. The pooled RR for in-hospital mortality was 1.45 (95 % CI 1.32-1.60, p < 0.00001, I (2 = )24 %). New-onset atrial fibrillation was also associated with increased ICU mortality, ICU and in-hospital length of stay and stroke. New-onset atrial fibrillation occurred more in the elderly, those with a prior history of cardiovascular and respiratory disease, and those with increased severity of illness.
  
  
  CONCLUSIONS
  Prospective randomised trials are needed to clarify the significance of new-onset atrial fibrillation in sepsis, optimal treatment strategies for these patients, and the benefit of systemic anticoagulation. Physicians should be aware that new-onset atrial fibrillation in sepsis is not merely an observed temporary arrhythmia but a marker of poor prognosis and should be managed accordingly.
authors.affiliation: McMaster University, Division of Cardiology, Hamilton, Ontario Canada Hamilton Health Sciences Centre, 237 Barton Street East, Office 329, 3 Lower North, L8L 2X2, Hamilton, Ontario, Canada, sumeet.gandhi@medportal.ca.
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gandhi
authors.forename: Dhanjit
authors.initials: D
authors.lastname: Litt
authors.forename: Neeraj
authors.initials: N
authors.lastname: Narula