title: Critical appraisal of the recent data published on the link between insulin and cancer.
abstract: Recent publications indicate a possible association between newer analogue insulin Glargine and cancer. However all these data were observational in nature and subject to lot of methodological errors. It is practically impossible to derive at a cause and effect relationship based on these observational studies. There are several confounding factors like hyperinsulinemia, obesity and smoking, which independently can be associated with cancer risk. This review looks into the recently published observational studies from the methodological point of view and whether such a negative association can indeed be drawn as a conclusion. Several methodological defects were identified in the process of scrutiny and we concluded it is not possible to conclude that there is an association between Glargine use and cancer. However long-term prospective data is required to come to definite conclusion.
authors.affiliation: University of Glamorgan, UK.
authors.forename: Samit
authors.initials: S
authors.lastname: Ghosal
authors.forename: Jeff
authors.initials: J
authors.lastname: Stephens
authors.forename: Annalie
authors.initials: A
authors.lastname: Van Deventer
authors.forename: Vikas
authors.initials: V
authors.lastname: Mital
authors.forename: Priyangika
authors.initials: P
authors.lastname: Jayasinghe
authors.forename: Moien
authors.initials: M
authors.lastname: Khan
authors.forename: Loui
authors.initials: L
authors.lastname: Setch
authors.forename: Bruno
authors.initials: B
authors.lastname: Pauly
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D000069036:Insulin Glargine / Q000009:adverse effects*; D009369:Neoplasms / Q000139:chemically induced*
chemical_list: D007004:Hypoglycemic Agents; D000069036:Insulin Glargine