title: Carcinosarcoma of the ureter with a small cell component: report of a rare pathologic entity and potential for diagnostic error on biopsy.
abstract: Carcinosarcomas of the ureter are rare biphasic neoplasms, composed of both malignant epithelial (carcinomatous) and malignant mesenchymal (sarcomatous) components. Carcinosarcomas of the urinary tract are exceedingly rare. We report a unique case of a carcinosarcoma of the ureter with a chondrosarcoma and small cell tumor component arising in a 68-year-old male who presented with microscopic hematuria. CT intravenous pyelogram revealed right-sided hydroureter and hydronephrosis with thickening and narrowing of the right ureter. The patient underwent robot-assisted ureterectomy with bladder cuff excision and subsequent adjuvant chemotherapy. The patient is disease-free at 32 months after treatment. We provide a brief synoptic review of carcinosarcoma of the ureter and bladder with utilization of immunohistochemical (IHC) stains and potential diagnostic pitfalls.
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA.
authors.forename: Kent
authors.initials: K
authors.lastname: Newsom
authors.affiliation: Department of Urology, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Bayo
authors.initials: B
authors.lastname: Tojuola
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA.
authors.forename: Samer
authors.initials: S
authors.lastname: Al-Quran
authors.affiliation: South Lake Hospital in Partnership with Orlando Health, 1900 Don Wickham Drive, Clermont, FL 34711, USA.
authors.forename: Sijo
authors.initials: S
authors.lastname: Parekattil
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA.
authors.forename: William
authors.initials: W
authors.lastname: Hamilton
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA.
authors.forename: Lizette
authors.initials: L
authors.lastname: Vila Duckworth