title: Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
abstract: Deciphering and storing information coded in different firing patterns are important properties of neuronal networks, as they allow organisms to respond and adapt to external and internal events. Here we report that hippocampal CA1 pyramidal neurons respond to brief bursts of high-frequency stimulation (HFS) and θ burst stimulation (TBS) with long-lasting enhanced responses (long-term potentiation [LTP]), albeit by engaging different signaling pathways. TBS induces LTP through calpain-1-mediated suprachiasmatic nucleus circadian oscillatory protein degradation, ERK activation, and actin polymerization, whereas HFS requires adenosine A2 receptors, PKA, and actin polymerization. TBS- but not HFS-induced LTP is impaired in calpain-1 knock-out mice. However, TBS-induced LTP and learning impairment in knock-out mice are restored by activating the HFS pathway. Thus, different patterns of rhythmic activities trigger potentiation by activating different pathways, and cross talks between these can be used to restore LTP and learning when elements of the pathways are impaired.
authors.affiliation: Graduate College of Biomedical Sciences and Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
authors.forename: Guoqi
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Graduate College of Biomedical Sciences and College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766, and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Graduate College of Biomedical Sciences and.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766, and.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Bi
authors.affiliation: Graduate College of Biomedical Sciences and mbaudry@westernu.edu.
authors.forename: Michel
authors.initials: M
authors.lastname: Baudry
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D002154:Calpain / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D003214:Conditioning, Classical; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D017774:Long-Term Potentiation; D020935:MAP Kinase Signaling System; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D043683:Receptors, Adenosine A2 / Q000378:metabolism; D013826:Theta Rhythm
chemical_list: D000199:Actins; D009687:Nuclear Proteins; D043683:Receptors, Adenosine A2; D017868:Cyclic AMP-Dependent Protein Kinases; C519282:PHLPP1 protein, mouse; D010749:Phosphoprotein Phosphatases; D002154:Calpain; C112682:Capn1 protein, mouse
keywords: ERK; PKA; calpain; hippocampus; learning; long-term potentiation