title: Tackling the achilles' heel of genetic testing.
abstract: Assigning pathogenicity to rare genetic variants is at its hardest with the enormous titin gene, but comprehensive genomic analysis makes the task more tractable (Roberts et al., this issue).
authors.affiliation: Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, U.K. hugh.watkins@rdm.ox.ac.uk.
authors.forename: Hugh
authors.initials: H
authors.lastname: Watkins
mesh_terms: D000483:Alleles; D064211:Connectin / Q000235:genetics*; D006321:Heart / Q000502:physiology*; D006801:Humans; D009154:Mutation; D014158:Transcription, Genetic
chemical_list: D064211:Connectin