title: Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis.
abstract: BACKGROUND
  Genetic analyses including genome-wide association studies have reported an intronic single nucleotide polymorphism (SNP) rs1006737 in CACNA1C gene (encoded calcium channel, voltage-dependent, L type, alpha 1C subunit) as a risk factor for schizophrenia in European populations. The replications in other ethnic populations such as East Asians have also been conducted, but the results were inconsistent, either likely due to the limited sample size of single study or genetic heterogeneity between continental populations on this locus.
  
  
  METHODS
  We performed a comprehensive meta-analysis of all available samples from existing studies of East Asian populations, including a total of 9,432 cases and 10,661 controls, to further confirm whether CACNA1C rs1006737 is an authentic risk SNP for schizophrenia in East Asian populations.
  
  
  RESULTS
  Our results revealed a significant association between rs1006737 and schizophrenia (allelic model, P = 4.39 × 10(-6) , pooled odds ratio [OR] = 1.20), and the results were much strengthened when the European and East Asian samples were combined together (P = 2.40 × 10(-17) , pooled OR = 1.12). There is no significant heterogeneity or publication bias between individual studies, and removal of any single study still remained significant associations between rs1006737 and schizophrenia.
  
  
  CONCLUSIONS
  Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-resource, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan, China.|Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Qiao
authors.affiliation: Department of Radiology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Zongfang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Laboratory for Conservation and Utilization of Bio-resource, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan, China.|State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Laboratory for Conservation and Utilization of Bio-resource, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, Yunnan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
mesh_terms: D001208:Asia / Q000208:ethnology; D020746:Calcium Channels, L-Type / Q000235:genetics*; D016022:Case-Control Studies; D005060:Europe / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type
keywords: CACNA1C; East Asian; European; rs1006737; schizophrenia