title: [Yimusake Tablet: safe and efficacious for premature ejaculation].
abstract: OBJECTIVE
  To objectively evaluate the efficacy and safety of Yimusake Tablet in the treatment of premature ejaculation (PE) through a multi-centered large-sample trial.
  
  
  METHODS
  We conducted a multi-centered, open, fixed-dose, and self-compared clinical trial among 300 patients with diagnosed PE. The trial lasted 12 weeks, including 4 weeks without any medication and 8 weeks of treatment with Yimusake Tablet, 2 pills (1 g) per night. We observed the intravaginal ejaculation latency time (IELT) before and after treatment, evaluated the safety of medication, and performed a questionnaire investigation on the patients' satisfaction.
  
  
  RESULTS
  Of the 300 PE patients, 288 accomplished the clinical trial. The patients ranged in age from 22 to 60 years, averaging at 31.6 years. The mean IELT of the patient was 62.5 seconds at baseline, 168.9 seconds after 4 weeks of treatment with Yimusake Tablet, and 222.2 seconds after 8 weeks of medication. Among the 157 patients with normal erectile function (IIEF >21), the mean IELT was 71.4 seconds before treatment, 147.4 seconds after 4 weeks of medication, and 172.5 seconds after 8 weeks of medication. The patients' satisfaction was significantly increased after treatment. Those complicated by mild to moderate erectile dysfunction achieved different degrees of improvement in the IIEF-5 score, with a mean increase of 3.8. Only a few patients experienced mild adverse events, including constipation, dry mouth, nose bleeding, abdominal pain, and lumbosacral pain, which were all relieved without drug withdrawal.
  
  
  CONCLUSIONS
  Yimusake Tablet is a safe and effective medicine for the treatment of PE.
authors.affiliation: Department of Urology, Peking University Third Hospital, Beijing, China.
authors.forename: Lian-ming
authors.initials: LM
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Kai
authors.initials: K
authors.lastname: Hong
authors.forename: Fu-biao
authors.initials: FB
authors.lastname: Li
authors.forename: Ji-xiu
authors.initials: JX
authors.lastname: Xu
authors.forename: Xiang-sheng
authors.initials: XS
authors.lastname: Zhang
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Mao
authors.forename: Shao-hu
authors.initials: SH
authors.lastname: Zhou
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.lastname: Chen Ming
authors.forename: Xiao-yong
authors.initials: XY
authors.lastname: Pu
authors.forename: Cheng-bin
authors.initials: CB
authors.lastname: Zhu
authors.forename: Guo-sheng
authors.initials: GS
authors.lastname: Yang
authors.forename: Liang-hong
authors.initials: LH
authors.lastname: Ma
authors.forename: Sheng-li
authors.initials: SL
authors.lastname: Ma
authors.forename: Xiang-an
authors.initials: XA
authors.lastname: Tu
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Deng
authors.forename: Xiang-zhou
authors.initials: XZ
authors.lastname: Sun
authors.forename: You-sheng
authors.initials: YS
authors.lastname: Yao
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Jia
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Ma
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010410:Penile Erection; D008517:Phytotherapy; D061686:Premature Ejaculation / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D013607:Tablets; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets