title: Candida fermentati as a cause of persistent fungemia in a preterm neonate successfully treated by combination therapy with amphotericin B and caspofungin.
abstract: A case of persistent candidemia in a preterm neonate caused by Candida fermentati, identified by sequencing of the internally transcribed spacer region of ribosomal DNA (rDNA), is described. The neonate was treated for 30 days by combination therapy with amphotericin B (AmBisome) and caspofungin with a successful outcome, and no drug-related side effects were observed.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait Maternity Hospital, Shuwaikh, Kuwait.
authors.forename: Noura
authors.initials: N
authors.lastname: Al-Sweih
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
authors.forename: Suhail
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
authors.forename: Leena
authors.initials: L
authors.lastname: Joseph
authors.affiliation: Maternity Hospital, Shuwaikh, Kuwait.
authors.forename: Seema
authors.initials: S
authors.lastname: Khan
authors.affiliation: Mycology Reference Laboratory, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Vayalil
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
authors.forename: Rachel
authors.initials: R
authors.lastname: Chandy
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait Mycology Reference Laboratory, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait zkhan@hsc.edu.kw.
authors.forename: Ziauddin
authors.initials: Z
authors.lastname: Khan
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D058387:Candidemia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D000077336:Caspofungin; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021901:DNA, Intergenic / Q000737:chemistry / Q000235:genetics; D004359:Drug Therapy, Combination / Q000379:methods; D054714:Echinocandins / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D055666:Lipopeptides; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021901:DNA, Intergenic; D054714:Echinocandins; D055666:Lipopeptides; D000666:Amphotericin B; D000077336:Caspofungin