title: [Insertion/deletion polymorphism of IL1A 3'-UTR associated with the susceptibility of prostate cancer ].
abstract: OBJECTIVE
  To identify the association between the insertion/deletion polymorphism of interleukin- 1A gene (IL1A) and the susceptibility of prostate cancer (PCA).
  
  
  METHODS
  We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/ deletion polymorphism (rs3783553) in 3'-UTR of IL1A gene was genotyped by PCR-RFLP method.
  
  
  RESULTS
  The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (P<0. 001, OR=O. 48, 95%CI: 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0. 001,OR=0. 56,95% CI: 0. 40-0. 79).
  
  
  CONCLUSIONS
  TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.
authors.affiliation: Department of Urology, Sichaun Cancer Hospital, Chengdu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liao
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Pu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Zeng
authors.initials: Z
authors.lastname: Li
authors.forename: Ying-ming
authors.initials: YM
authors.lastname: Xiao
authors.forename: Sheng-ke'
authors.initials: SK
authors.lastname: Yang
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C508584:IL1A protein, human; D053582:Interleukin-1alpha