title: International standardization and classification of human papillomavirus types.
abstract: Established Human Papillomavirus (HPV) types, up to HPV202, belong to 49 species in five genera. International standardization in classification and quality standards for HPV type designation and detection is ensured by the International HPV Reference Center. The center i) receives clones of potentially novel HPV types, re-clones and re-sequences them. If confirmed, an HPV type number is assigned and posted on www.hpvcenter.se. ii) distributes reference clone samples, for academic research, under Material Transfer Agreements agreed with the originator. iii) provides preliminary checking of whether new sequences represent novel types iv) issues international proficiency panels for HPV genotyping. The rate of HPV type discovery is increasing, probably because of metagenomic sequencing. γ-genus today contains 79HPV types and 27 species, surpassing ∝ and β genera with 65 and 51HPV types, respectively. Regular issuing of proficiency panels based on HPV reference clones has resulted in global improvement of HPV genotyping services.
authors.affiliation: International HPV Reference Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.
authors.forename: Davit
authors.initials: D
authors.lastname: Bzhalava
authors.affiliation: International HPV Reference Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.
authors.forename: Carina
authors.initials: C
authors.lastname: Eklund
authors.affiliation: International HPV Reference Center, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden; Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden. Electronic address: joakim.dillner@ki.se.
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
mesh_terms: D005838:Genotype; D006801:Humans; D038622:Internationality; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000821:virology*; D010802:Phylogeny; D014773:Virology / Q000379:methods / Q000592:standards*
keywords: Human papillomavirus