title: Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients.
abstract: OBJECTIVE
  Vitamin D deficiency is an independent risk factor for cardiovascular mortality. The relationship between vitamin D level and left ventricle (LV) myocardial performance index (MPI=Tei index), which incorporates both LV systolic function and diastolic function, was not investigated in previous studies. We hypothesized that vitamin D level may be associated with LV function and geometry. We aimed to investigate the association between serum 25-hydroxyvitamin D (25 [OH] D) levels and MPI and LV hypertrophy in hypertensive patients with newly diagnosed and preserved ejection fraction.
  
  
  METHODS
  We studied 151 sequential newly diagnosed hypertensive subjects who lived in the Çukurova region without known cardiovascular risk factors or overt heart disease (mean age: 62.8±10.4 years). Serum 25 (OH) D was measured using a direct competitive chemiluminescent immunoassay. The patients were divided into two groups according to serum 25 (OH) D level: vitamin D-non-deficient group (vitamin D≥ 20.00 ng/mL, n=53) and vitamin D-deficient group (vitamin D< 20.00 ng/mL, n=98). MPI was defined as the sum of isovolumic contraction and relaxation times divided by the ejection time. LV mass index (LVMI) was calculated by using the Devereux formula and body surface area.
  
  
  RESULTS
  MPI and LVMI values were lower and low-density lipoprotein (LDL) levels were higher in patients who were vitamin D-non-deficient than patients who were vitamin D-deficient (p<0.05 for all). Multivariate linear regression analysis showed that serum 25 (OH) D was independently associated with MPI (β=-0.426, p<0.001), LVMI (β=-0.345, p=<0.001), and LDL (β=0.140, p<0.026).
  
  
  CONCLUSIONS
  Lower serum 25 (OH) D levels are significantly associated with impaired myocardial performance and LVMI.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital; Adana-Turkey. atanerseker@hotmail.com.
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Ahmet Oytun
authors.initials: AO
authors.lastname: Baykan
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.forename: Hazar
authors.initials: H
authors.lastname: Harbalıoğlu
authors.forename: Gülhan
authors.initials: G
authors.lastname: Yüksel Kalkan
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypaklı
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Şen
authors.forename: Mevlüt
authors.initials: M
authors.lastname: Koç
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D