title: Post-myocardial infarct inflammation and the potential role of cell therapy.
abstract: Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on cardiac stem cells and regenerative biology. This review summarizes the current knowledge on molecular and cellular processes implicated in post-infarction inflammation and discusses the potential beneficial role cell therapy might play in this process. Due to its immunomodulatory properties, the mesenchymal stromal cell is a candidate to reverse the disease progression of the infarcted heart towards heart failure, and therefore is emphasized in this review.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, RC, Leiden, The Netherlands.
authors.forename: Vanessa-leigh
authors.initials: VL
authors.lastname: van Zuylen
authors.forename: Melina C
authors.initials: MC
authors.lastname: den Haan
authors.forename: Sacha B
authors.initials: SB
authors.lastname: Geutskens
authors.forename: Helene
authors.initials: H
authors.lastname: Roelofs
authors.forename: Willem E
authors.initials: WE
authors.lastname: Fibbe
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schalij
authors.forename: Douwe E
authors.initials: DE
authors.lastname: Atsma
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy; D009203:Myocardial Infarction / Q000276:immunology / Q000628:therapy*; D015427:Reperfusion Injury / Q000276:immunology / Q000628:therapy