title: Synthesis and properties of novel water-soluble fullerene-glycine derivatives as new materials for cancer therapy.
abstract: Novel water-soluble fullerene-glycine derivatives were synthesized by means of simple organic chemistry. They are completely soluble in water, yielding a clear brown solution. The products were characterized by fourier transform infrared (FTIR), ultraviolet-visible spectroscopy (UV-Vis), (1)H NMR, (13)C NMR, thermogravimetric analyses (TGA), and scanning electron microscopy (SEM). The assembly behavior of water-soluble fullerene-glycine derivatives was investigated by SEM. The results show that the fullerene-glycine derivatives create morphology that is sphere-like. The cytotoxicity to cancer cell lines of the fullerene-glycine derivatives was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) and flow cytometry. The results show that fullerene-glycine derivatives exhibit mortality and apoptosis of the cells which increased with the increase of fullerene-glycine derivative concentration. The cytotoxicity mechanism of fullerene-glycine derivatives was investigated for the first time. Novel water-soluble fullerene-glycine derivatives were synthesized by means of simple organic chemistry. The products were characterized by FTIR, UV-Vis, (1)H NMR, (13)C NMR, TGA, and SEM. The bioactivities of fullerene-glycine derivative materials have been tested, and the results show that compared with the fullerene complex, the fullerene-glycine derivative materials exhibit mortality and apoptosis of the cells which increased with the increase of fullerene-glycine derivative concentration. SEM images showed the macrostructure of fullerene-glycine derivative materials was spheres.
authors.affiliation: Tianjin University of Science and Technology, Tianjin, 300222, People's Republic of China, wangziqing1978@163.com.
authors.forename: Guichang
authors.initials: G
authors.lastname: Jiang
authors.forename: Fen
authors.initials: F
authors.lastname: Yin
authors.forename: Jihua
authors.initials: J
authors.lastname: Duan
authors.forename: Guangtao
authors.initials: G
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D045744:Cell Line, Tumor; D015195:Drug Design; D005434:Flow Cytometry; D037741:Fullerenes / Q000737:chemistry*; D005998:Glycine / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry; D009369:Neoplasms / Q000628:therapy*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D037741:Fullerenes; D014867:Water; D002244:Carbon; D005998:Glycine