title: Using chemical benchmarking to determine the persistence of chemicals in a Swedish lake.
abstract: It is challenging to measure the persistence of chemicals under field conditions. In this work, two approaches for measuring persistence in the field were compared: the chemical mass balance approach, and a novel chemical benchmarking approach. Ten pharmaceuticals, an X-ray contrast agent, and an artificial sweetener were studied in a Swedish lake. Acesulfame K was selected as a benchmark to quantify persistence using the chemical benchmarking approach. The 95% confidence intervals of the half-life for transformation in the lake system ranged from 780-5700 days for carbamazepine to <1-2 days for ketoprofen. The persistence estimates obtained using the benchmarking approach agreed well with those from the mass balance approach (1-21% difference), indicating that chemical benchmarking can be a valid and useful method to measure the persistence of chemicals under field conditions. Compared to the mass balance approach, the benchmarking approach partially or completely eliminates the need to quantify mass flow of chemicals, so it is particularly advantageous when the quantification of mass flow of chemicals is difficult. Furthermore, the benchmarking approach allows for ready comparison and ranking of the persistence of different chemicals.
authors.affiliation: Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University , 10691 Stockholm, Sweden.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zou
authors.forename: Michael
authors.initials: M
authors.lastname: Radke
authors.forename: Amelie
authors.initials: A
authors.lastname: Kierkegaard
authors.forename: Matthew
authors.initials: M
authors.lastname: MacLeod
authors.forename: Michael S
authors.initials: MS
authors.lastname: McLachlan
mesh_terms: D019985:Benchmarking; D002220:Carbamazepine / Q000032:analysis / Q000493:pharmacokinetics; D003287:Contrast Media / Q000032:analysis; D006207:Half-Life; D007660:Ketoprofen / Q000032:analysis / Q000493:pharmacokinetics; D060106:Lakes / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis; D013548:Sweden; D013549:Sweetening Agents / Q000032:analysis; D013843:Thiazines / Q000032:analysis / Q000493:pharmacokinetics; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D004364:Pharmaceutical Preparations; D013549:Sweetening Agents; D013843:Thiazines; D014874:Water Pollutants, Chemical; D002220:Carbamazepine; D007660:Ketoprofen; C006362:acetosulfame