title: An alternative to nerve repair using an antioxidant compound: a histological study in rats.
abstract: The fascicular composition and organisation of the inferior alveolar nerve (IAN) were determined to confirm the microarchitecture of the IAN bundles into each of the mandibular teeth, including the composition of the mental nerve. The aim of this study was to evaluate peripheral nerve repair after the application of an antioxidant compound to the damaged nerve tissue to elevate the concentration and bioavailability of elements capable of favouring tissue repair. Twenty-five Wistar rats were divided into groups: The Control 1 (Ctl 1) (n = 5) animals had the ischiatic nerve exposed with no suture injury and were sacrificed at 30 days post-operatively. The Control 2 (Ctl 2) (n = 10) animals had the ischiatic nerve exposed, and the nerve was injured using suture in three distinct regions. In the experimental (Exp) animals (n = 10), an antioxidant organic compound was applied to the nerve injury site. The animals with nerve injury (Ctl2 and Exp group) were sacrificed at 15 and 30 days post-operatively. The histological analysis showed less degeneration in the Exp group at 15 and 30 days post-operatively. Nerve neoformation forming a connection between the distal and proximal suture sites was observed in the experimental group. This study presented an alternative to nerve repair using an antioxidant compound.
authors.affiliation: Department of Health Sciences - School of Dentistry, 9 de Julho University, São Paulo, SP, Brazil.
authors.forename: Marcos B
authors.initials: MB
authors.lastname: Salles
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Gehrke
authors.forename: Samuel
authors.initials: S
authors.lastname: Koo
authors.forename: Sergio
authors.initials: S
authors.lastname: Allegrini
authors.forename: Sizue O
authors.initials: SO
authors.lastname: Rogero
authors.forename: Tamiko I
authors.initials: TI
authors.lastname: Ikeda
authors.forename: Áurea S
authors.initials: ÁS
authors.lastname: Cruz
authors.forename: Elio H
authors.initials: EH
authors.lastname: Shinohara
authors.forename: Marcelo
authors.initials: M
authors.lastname: Yoshimoto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants