title: Triglyceride to high-density lipoprotein cholesterol ratio and carotid intima-medial thickness in Chinese adolescents with newly diagnosed type 2 diabetes mellitus.
abstract: OBJECTIVE
  To investigate the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and carotid intima-medial thickness (CIMT) in Chinese youth and adolescents with newly diagnosed type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Ninety-eight subjects aged 10-24 yr with newly-diagnosed T2DM had general inflammation, anthropometric, laboratory and CIMT data collected, and were divided into three groups based on TG/HDL-C tertiles.
  
  
  RESULTS
  There were no significant differences in gender, age, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), and carotid arterial diameter (CAD) among the groups based on TG/HDL-C tertiles. Across TG/HDL-C tertiles, there was a significant progressive increase in body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), homeostasis model assessment-estimated insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and CIMT (all P < 0.01 or P < 0.05), while HDL-C was decreased significantly across the groups (P < 0.01). In general linear regression model, TG/HDL-C was an independent determinant of CIMT even after adjusting for BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, HbA1c and HOMA-IR.
  
  
  CONCLUSIONS
  TG/HDL-C ratio, the marker of small dense LDL particles, is an independent determinant of CIMT in Chinese youth and adolescents with newly diagnosed T2DM, and may be a simple and helpful tool in predicting the increased CIMT in such patients.
authors.affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: You-Ping
authors.initials: YP
authors.lastname: Deng
authors.affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Su-Xin
authors.initials: SX
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, China.
authors.forename: Jia-Zhong
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000706:statistics & numerical data; D059168:Carotid Intima-Media Thickness; D002648:Child; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides
keywords: carotid intima-medial thickness; triglyceride to high-density lipoprotein cholesterol ratio; type 2 diabetes mellitus; youth and adolescent