title: Metformin-related acidosis in a woman while performing Haj: a conservative approach.
abstract: Metformin is a first-line oral anti-hyperglycemic agent. It decreases insulin resistance, decreases hepatic glucose output and enhances peripheral glucose uptake. Metformin is used as a monotherapy in combination with other oral hypoglycemic agents. A major side-effect of metformin is lactic acidosis. The elimination of metformin is mainly through the kidneys, and raised plasma concentrations can cause lactic acidosis. Provided there is no overdose, metformin associated lactic acidosis rarely develops in patients without co-morbidities such as renal or hepatic insufficiency, acute infection or severe dehydration. Herein, we report a case of metformin-induced metabolic acidosis occurring in a woman who was severely dehydrated after performing Haj and treated conservatively.
authors.affiliation: Intensive Care Department, King Faisal Hospital, Makkah, Kingdom of Saudi Arabia.
authors.forename: Riyazuddin S H
authors.initials: RS
authors.lastname: Ansari
authors.forename: Ahmed Fouad
authors.initials: AF
authors.lastname: Mady
authors.forename: Hatem Othman
authors.initials: HO
authors.lastname: Qutub
authors.forename: Eidah
authors.initials: E
authors.lastname: Althomaly
authors.forename: Zainab Abdulaziz
authors.initials: ZA
authors.lastname: Alzayer
authors.forename: Amna A R
authors.initials: AA
authors.lastname: Moulana
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000628:therapy; D003681:Dehydration / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007514:Islam; D008687:Metformin / Q000009:adverse effects*; D008875:Middle Aged; D014195:Travel
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin