title: [Neurotoxicity of radiation].
abstract: It is well-known that the central nervous system is thoroughly resistant to ionizing radiation as high-dose radiation exposure is required for causing neuronal death. In contrast, recent studies have revealed that the hippocampus, which could be the main organ involved in disorder of higher brain functions after radiation therapy, contains radiation-sensitive cell fractions. In this paper, the basics of radiation effects and the molecular mechanism of neurotoxicity of radiation have been reviewed and discussed.
authors.affiliation: Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University.
authors.forename: Keiji
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D016923:Cell Death / Q000528:radiation effects; D002490:Central Nervous System / Q000473:pathology*; D004249:DNA Damage; D006801:Humans; D009474:Neurons / Q000473:pathology*; D011827:Radiation; D011878:Radiotherapy / Q000009:adverse effects*