title: Intensive local thermotherapy cleared extensive viral warts in a patient with systemic lupus erythematosus.
abstract: OBJECTIVE
  A variety of medications and procedures are available for the treatment of warts, but it appeared the treatment response in systemic lupus erythematosus (SLE) patients is poor. It is necessary to investigate the feasibility, safety and efficacy of local thermotherapy for extensive viral warts.
  
  
  METHODS
  A SLE patient on systemic steroid developed extensive viral warts on both her hands and feet for months. She had a high score of SLE Disease Activity Index (SLEDAI), up to 30, and was extensively treated with high and prolonged dosage of corticosteroid and intermittent use of cyclophosphamide. We applied local hyperthermia at 44 °C on a target lesion for 30 min on days 1, 2, 3, 17, 18, a protocol which has been successfully used in treating viral warts. There was no sign of clinical response in a 3-month follow-up. Then we treated the patient on a once-a-week protocol.
  
  
  RESULTS
  All the lesions cleared in ten weeks and there was no sign of recurrence.
  
  
  CONCLUSIONS
  This observation suggests that more intensive local hyperthermia is required for clearing viral warts in SLE.
authors.affiliation: Department of Dermatology, No.1 Hospital of China Medical University , Shenyang , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Huo
authors.forename: Rui-Qun
authors.initials: RQ
authors.lastname: Qi
authors.forename: Lanting
authors.initials: L
authors.lastname: Hu
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Gao
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005533:Foot Dermatoses / Q000628:therapy* / Q000821:virology; D006801:Humans; D006979:Hyperthermia, Induced; D008180:Lupus Erythematosus, Systemic / Q000628:therapy* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics; D016896:Treatment Outcome; D014860:Warts / Q000628:therapy* / Q000821:virology
chemical_list: D004279:DNA, Viral
keywords: Human papillomavirus; hyperthermia; systemic lupus erythematosus; viral warts