title: Structural organization of glial cells at the border between the neurotransplant and recipient brain.
abstract: Integration of fetal hippocampal dentate fascia neurotransplants with the neocortical somatosensory region in adult rats was studied by electron microscopy. The growth of nerve fiber through the neurotransplant/brain border formed by the glial cells was studied. The interface zone was organized by various astrocyte subpopulations and ependymocytes forming multilamellar accumulations in some sites of the interface. These conglomerations of the glial cells and their processes did not prevent the growth of axonal and axodendritic bundles; moreover, fibrous astrocyte axons accompanied them. Under conditions of immature nervous tissue transplantation to the focus of mature brain damage, the glial cells created a substrate in the interface permeable for nerve fibers, thus promoting the functional integration of the neurotransplant.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, the Russian Academy of Sciences, Pushchino, Moscow Region, Russian, zhuravleva@iteb.ru.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Zhuravleva
authors.forename: A A
authors.initials: AA
authors.lastname: Ermakov
authors.forename: G I
authors.initials: GI
authors.lastname: Zhuravlev
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar