title: Clostridium tertium bacteremia in a patient with glyphosate ingestion.
abstract: BACKGROUND
  Clostridium tertium is distributed in the soil and in animal and human gastrointestinal tracts. C. tertium has been isolated from patients with blood diseases, immune disorders, and abdominal surgeries. Glyphosate is toxic, causing cause eye and skin irritation, gastrointestinal pain, and vomiting. Ingestion of herbicides modiﬁes the gastrointestinal environment, which stresses the living organisms. However, there has been little attention to cases of bacteremia in patients recovering from suicide attempt by ingesting herbicide.
  
  
  METHODS
  Clostridium tertium was identified in a 44-year-old female who attempted suicide by glyphosate (a herbicide) ingestion. The 16S rRNA sequences from all colonies were 99% identical with that of C. tertium (AB618789) found on a BLAST search of the NCBI database. The bacterium was cultured on TSA under aerobic and anaerobic conditions. Antimicrobial susceptibility tests performed under both aerobic and anaerobic conditions showed that the bacterium was susceptible to penicillin, a combination of β-lactamase inhibitor and piperacillin or amoxicillin, and first- and second- generation cephalosporins. However, it was resistant to third- and fourth-generation cephalosporins.
  
  
  CONCLUSIONS
  Glyphosate herbicide might be a predisposing factor responsible for the pathogenesis of C. tertium. The results highlight the need for careful diagnosis and selection of antibiotics in the treatment of this organism.
authors.affiliation: Bio-safety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
authors.forename: Myung-Jo
authors.initials: MJ
authors.lastname: You
authors.affiliation: Bio-safety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
authors.forename: Gee-Wook
authors.initials: GW
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine and Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea.
authors.forename: Chang-Seop
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000175:diagnosis / Q000209:etiology*; D003015:Clostridium Infections / Q000175:diagnosis / Q000209:etiology*; D048010:Clostridium tertium / Q000302:isolation & purification*; D003679:Deglutition; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning; D006801:Humans; D000097797:Glyphosate
chemical_list: D005998:Glycine; D006540:Herbicides; D000097797:Glyphosate