title: Maghemite based silicone composite for arterial embolization hyperthermia.
abstract: Maghemite nanoparticle based silicone composite for application in arterial embolization hyperthermia is developed. It possesses embolization ability, high heating efficiency in alternating magnetic fields and radiopaque property. The initial components of the composite are selected so that the material stays liquid for 20min, providing the opportunity for transcatheter transportation and filling of the tumour vascular system. After this induction period the viscosity increases rapidly and soft embolus is formed which is able to occlude the tumour blood vessels. The composite is thermally stable up to 225°C, displays rubber-elastic properties and has a thermal expansion coefficient higher than that of blood. Maghemite nanoparticles uniformly distributed in the composite provide its rapid heating (tens of °Cmin(-1)) due to Neel magnetization relaxation. Required X-ray contrast of composite is achieved by addition of potassium iodide.
authors.affiliation: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, nad Ovcirnou 3685, 76001 Zlin, Czech Republic; Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, T.G. Masaryk Sq. 275, 762 72 Zlin, Czech Republic.
authors.forename: Ilona S
authors.initials: IS
authors.lastname: Smolkova
authors.affiliation: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, nad Ovcirnou 3685, 76001 Zlin, Czech Republic. Electronic address: nekazan@yahoo.com.
authors.forename: Natalia E
authors.initials: NE
authors.lastname: Kazantseva
authors.affiliation: Russian Research Centre for Radiology and Surgical Technologies in St. Petersburg, Leningradskaya st.70, Pesochny, St. Petersburg 197758, Russian Federation.
authors.forename: Kira N
authors.initials: KN
authors.lastname: Makoveckaya
authors.affiliation: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, nad Ovcirnou 3685, 76001 Zlin, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Smolka
authors.affiliation: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, nad Ovcirnou 3685, 76001 Zlin, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Saha
authors.affiliation: Russian Research Centre for Radiology and Surgical Technologies in St. Petersburg, Leningradskaya st.70, Pesochny, St. Petersburg 197758, Russian Federation.
authors.forename: Anatoly M
authors.initials: AM
authors.lastname: Granov
mesh_terms: D000818:Animals; D004548:Elasticity; D004621:Embolization, Therapeutic; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D053761:Nanocomposites / Q000737:chemistry*; D011193:Potassium Iodide / Q000737:chemistry; D012828:Silicones / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D012828:Silicones; D011193:Potassium Iodide; C000499:ferric oxide
keywords: Arterial embolization hyperthermia; Embolic material; Maghemite nanoparticles; Radiopacity; Rheological properties; Specific loss power