title: Evaluation of toxicity to triclosan in rats following 28 days of exposure to aerosol inhalation.
abstract: The present study was conducted to investigate the potential subchronic toxicity of triclosan (TCS) in rats following 28 days of exposure by repeated inhalation. Four groups of six rats of each sex were exposed to TCS-containing aerosols by nose-only inhalation of 0, 0.04, 0.13, or 0.40 mg/L for 6 h/day, 5 days/week over a 28-day period. During the study period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. At 0.40 mg/L, rats of both sexes exhibited an increase in the incidence of postdosing salivation and a decrease in body weight. Histopathological alterations were found in the nasal septum and larynx. There were no treatment-related effects in rats of either sex at ⩽0.13 mg/L. Under the present experimental conditions, the target organs in rats were determined to be the nasal cavity and larynx. The no-observed-adverse-effect concentration in rats was determined to be 0.13 mg/L.
authors.affiliation: Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Yang
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
authors.forename: Jung-Taek
authors.initials: JT
authors.lastname: Kwon
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
authors.forename: Ilseob
authors.initials: I
authors.lastname: Shim
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kim
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
authors.forename: Pilje
authors.initials: P
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address: toxkim@jnu.ac.kr.
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea. Electronic address: khlee@kitox.re.kr.
authors.forename: Kyuhong
authors.initials: K
authors.lastname: Lee
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage* / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014260:Triclosan / Q000008:administration & dosage* / Q000633:toxicity*
chemical_list: D000336:Aerosols; D014260:Triclosan
keywords: Inhalation; NOAEC; Nose-only exposure; Subchronic toxicity; Triclosan