title: Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the circulation.
abstract: Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex coordinates a systemic response that alters heart rate, cardiac contractility and peripheral vessel vasoconstriction. In this work, a coupled 3D-0D formulation for the short-term pressure regulation of the systemic circulation is presented. Including the baroreflex feedback mechanisms, a patient-specific model of the large arteries is subjected to a simulated head up tilt test. Comparative simulations with and without baroreflex control highlight the critical role that the baroreflex has in regulating variations in pressures within the systemic circulation.
authors.affiliation: Department of Biomedical Engineering, King's College London, London, SE1 7EH, UK, kevin.lau@kcl.ac.uk.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Lau
authors.forename: C Alberto
authors.initials: CA
authors.lastname: Figueroa
mesh_terms: D001158:Arteries / Q000502:physiology; D017704:Baroreflex / Q000502:physiology; D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003187:Compliance; D003198:Computer Simulation; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D016683:Supine Position; D018667:Tilt-Table Test; D014655:Vascular Resistance / Q000502:physiology