title: A bidirectional drug repositioning approach for Parkinson's disease through network-based inference.
abstract: Parkinson's Disease (PD) is one of the most prevailing neurodegenerative disorders. Novel computational approaches are required to find new ways of using the existing drugs or drug repositioning, as currently there exists no cure for PD. We proposed a new bidirectional drug repositioning method that consists of Top-down and Bottom-up approaches and finally gives information about significant repositioning drug candidates. This method takes into account of the topological significance of drugs in the tripartite Indication-drug-target network (IDTN) as well the significance of their targets in the PD-specific protein-protein interaction network (PPIN). 9 non-Parkinsonian drugs have been proposed as the significant repositioning candidates for PD. In order to find out the efficiency of the repositioning candidates we introduced a parameter called the On-target ratio (OTR). The average OTR value of final repositioning candidates has been found to be higher than that of known PD specific drugs.
authors.affiliation: Department of Information Engineering, Computer Science and Mathematics, University of L'Aquila, 67100, Italy. Electronic address: hindol.iserc@gmail.com.
authors.forename: Hindol
authors.initials: H
authors.lastname: Rakshit
authors.affiliation: Department of Biophysics, Bose Institute, Acharya J.C. Bose Centenary Building, P-1/12 C.I.T Scheme VII M, Kolkata 700054, India. Electronic address: chatterjee_paulami@yahoo.co.in.
authors.forename: Paulami
authors.initials: P
authors.lastname: Chatterjee
authors.affiliation: Department of Biophysics, Bose Institute, Acharya J.C. Bose Centenary Building, P-1/12 C.I.T Scheme VII M, Kolkata 700054, India. Electronic address: roydebjani13@gmail.com.
authors.forename: Debjani
authors.initials: D
authors.lastname: Roy
mesh_terms: D000978:Antiparkinson Agents / Q000737:chemistry / Q000627:therapeutic use; D019295:Computational Biology; D030541:Databases, Genetic; D062313:Databases, Pharmaceutical; D058492:Drug Repositioning / Q000379:methods* / Q000706:statistics & numerical data; D005819:Genetic Markers; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D060066:Protein Interaction Maps
chemical_list: D000978:Antiparkinson Agents; D005819:Genetic Markers
keywords: Drug repositioning; Indication-drug-target network; Parkinson's disease; Protein–protein interaction network; Topological significance