title: NOTA: a potent metallo-β-lactamase inhibitor.
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Anou M
authors.initials: AM
authors.lastname: Somboro
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Dileep
authors.initials: D
authors.lastname: Tiwari
authors.affiliation: Biomedical Resource Unit, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Linda A
authors.initials: LA
authors.lastname: Bester
authors.affiliation: Department of Virology, National Health Laboratory Service/University of KwaZulu-Natal, c/o Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
authors.forename: Raveen
authors.initials: R
authors.lastname: Parboosing
authors.affiliation: Department of Virology, National Health Laboratory Service/University of KwaZulu-Natal, c/o Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
authors.forename: Louis
authors.initials: L
authors.lastname: Chonco
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Hendrick G
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa Science for Life Laboratory, Drug Discovery and Development Platform, and Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
authors.forename: Per I
authors.initials: PI
authors.lastname: Arvidsson
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Tricia
authors.initials: T
authors.lastname: Naicker
authors.affiliation: Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa essacks@ukzn.ac.za.
authors.forename: Sabiha Y
authors.initials: SY
authors.lastname: Essack
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006573:Heterocyclic Compounds, 1-Ring / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D018440:beta-Lactam Resistance / Q000187:drug effects*; D065093:beta-Lactamase Inhibitors / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D065093:beta-Lactamase Inhibitors; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; C048993:1,4,7-triazacyclononane-N,N',N''-triacetic acid; D001618:beta-Lactamases
keywords: DOTA; MBLs; carbapenemases; metal-chelating agents