title: Correlation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement.
abstract: BACKGROUND
  The reported mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24 years. Prepubertal onset is thought to be rare.
  
  
  OBJECTIVE
  We sought to determine the prevalence of early-onset HS and to compare clinical characteristics between early-onset and normal-onset HS in a retrospective study.
  
  
  METHODS
  Data were collected from 855 patients with HS. Early-onset HS was defined as onset before the thirteenth birthday. Clinical characteristics were analyzed in relation to the age of onset.
  
  
  RESULTS
  In all, 66 patients (7.7%) reported early-onset HS. A family history for HS was significantly higher in early-onset patients (55.6% vs 34.2%; odds ratio 2.1, 95% confidence interval 1.2-3.6, P = .006). They developed inflammatory lesions at more body sites than patients with normal-onset HS (odds ratio 3.0, 95% confidence interval 1.8-4.9, P < .001). Distribution of the Hurley stages of severity showed no differences between the 2 groups (odds ratio 1.1, 95% confidence interval 0.7-1.8, P = .72).
  
  
  CONCLUSIONS
  Some data were based on patient-reported information.
  
  
  CONCLUSIONS
  Early-onset HS occurs more frequently than previously believed. Patients with early-onset HS often report a family history for HS and develop lesions at more body sites.
authors.affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: i.deckers@erasmusmc.nl.
authors.forename: Inge E
authors.initials: IE
authors.lastname: Deckers
authors.affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Hessel H
authors.initials: HH
authors.lastname: van der Zee
authors.affiliation: Department of Dermatology, Deventer Hospital, Deventer, The Netherlands.
authors.forename: Jurr
authors.initials: J
authors.lastname: Boer
authors.affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Errol P
authors.initials: EP
authors.lastname: Prens
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D020022:Genetic Predisposition to Disease; D017497:Hidradenitis Suppurativa / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D012189:Retrospective Studies
keywords: acne ectopica; acne inversa; age of onset; disease extent; disease severity; early onset; family history; genetic predisposition; hidradenitis suppurativa