title: The effect of nonsurgical periodontal treatment on serum and saliva chitotriosidase activities in patients with periodontitis and coronary artery disease.
abstract: BACKGROUND
  Plasma chitotriosidase activity, which is a marker of macrophage activation, has been reported to increase in inflammatory conditions and atherosclerosis. Chronic periodontitis has likely an important role in the development of coronary artery disease. In this study, we aimed to analyze the effect of chronic periodontitis on salivary and plasma chitotriosidase activities in patients with or without coronary atherosclerosis.
  
  
  METHODS
  Fifty subjects were divided into four groups as controls (n=13), periodontitis (n=11), coronary artery disease (n=13), and periodontitis + coronary artery disease (n=13). Plasma and saliva chitotriosidase activities were measured by a fluorimetric method in all groups before the nonsurgical treatment of periodontitis and 5 weeks posttreatment in periodontitis groups.
  
  
  RESULTS
  Salivary chitotriosidase activity was decreased after nonsurgical periodontal treatment in patients having periodontitis with or without coronary atherosclerosis. However, plasma activities remained unchanged.
  
  
  CONCLUSIONS
  Although this study has some limitations like small sample size and short study duration, it can suggest that salivary chitotriosidase can have the potential to be used as a very useful and practical marker to evaluate the success of the periodontal treatment and/or host response.
  
  
  RESULTS
  Salivary chitotriosidase can be used as a marker for the evaluation of the success of the periodontal treatment and/or host response.
authors.affiliation: Department of Periodontology, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mehmet Vehbi
authors.initials: MV
authors.lastname: Bal
authors.affiliation: Biochemistry Laboratory, TSK Rehabilitation Center, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Olgun
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Abaslı
authors.affiliation: Department of Periodontology, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Özdemir
authors.affiliation: Department of Cardiology, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Hürkan
authors.initials: H
authors.lastname: Kürşaklıoğlu
authors.affiliation: Department of Orthopedics, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ahmet Salim
authors.initials: AS
authors.lastname: Göktepe
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, TSK Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Ísmail
authors.initials: Í
authors.lastname: Kurt
keywords: chitotriosidase; chronic periodontitis; coronary artery disease; nonsurgical periodontal treatment