title: A Facile Synthesis, In vitro Antiinflammatory and Antioxidant activity of Novel Benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles.
abstract: The synthesis benzimidazolylpyrano [2,3-d] [1,3] thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.
authors.affiliation: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500 007, India ; Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, Thimmapur-505 481, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Malladi
authors.affiliation: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500 007, India.
authors.forename: R
authors.initials: R
authors.lastname: Anisetti
authors.affiliation: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500 007, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Rao
keywords: Benzimidazolylpyrano [2,3-d][1,3] thiazolocarbonitrile; Michael addition; antiinflammatory activity; antioxidant activity; cyclo condensation; mercaptoacetic acid