title: [Comorbidity -- mind and body interconnection based on the new findings].
abstract: Comorbidity is a multicausal, multidimensional, multifaced phenomenon in medicine. There are many different definitions of the co-occurrence of two or more disorders, but Feinstein's is the most acceptable. Although epidemiological data show a high prevalence of comorbidity of somatic and psychiatric disorders, it is still underrecognized and undertreated. There are many unanswered questions related to comorbidity, including whether comorbidity is a valid phenomenon; whether the epidemiological results have validity; what is the linkage between somatic and psychological processes; which factors take part in the bidirectional manifestation; how do we treat the involved disorders; what is the right organization to manage the patients. The aim of the author was to review different aspects of comorbidity with the help of new knowledge. The starting point of the interpretation was the concept of identical biological substrates (pathophysiological endpoint) that generate the development of somatic and psychiatric disorders. The formation of these substrates is influenced by risk factors, which depend or not on the person (stressors vs genes). The effects of risk factors and biological substrates are parallel to each other, but one of them is a dominant agent. The author's concept ("dominance theory") is based on new discoveries of the biological mechanisms of psychiatric processes to help to understand the phenomenon of comorbidity and develop new therapies. It is very important to recognize, to diagnose and treat comorbidity because of the prevalence of excess mortality is high and the morbidity burden influences the patient' quality of life.
authors.affiliation: Pozitron Diagnosztikai Központ, Budapest, Hungary. col.kovacs@gmail.com.
authors.forename: Gabor
authors.initials: G
authors.lastname: Kovacs
mesh_terms: D015897:Comorbidity; D003695:Delivery of Health Care / Q000458:organization & administration*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D001523:Mental Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D019222:Mind-Body Relations, Metaphysical; D057285:Precision Medicine; D015995:Prevalence; D011602:Psychophysiologic Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011603:Psychophysiology / Q000706:statistics & numerical data; D011788:Quality of Life; D012307:Risk Factors