title: Neuroprotective effects of treadmill exercise on BDNF and PI3-K/Akt signaling pathway in the cortex of transgenic mice model of Alzheimer's disease.
abstract: (AD). Although physical exercise and AD have received attention in the scientific literature, the mechanism through which treadmill exercise may impact the brain insulin signaling of AD has not been elucidated. This study aimed to evaluate the neuroprotective effects of treadmill exercise on apoptotic factors (Bcl-2/Bax ratio, caspase-3), HSP70, COX-2, BDNF and PI3-K/Akt signaling pathway in the cortex of NSE/hPS2m transgenic mice model of AD. Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group. In addition, treadmill exercise significantly increased the expression of BDNF and PI3K/Akt in Tg-exe group compared to Tg-con group. Consequently, treadmill exercise improves cognitive function possibly via activating neurotrophic factor, BDNF and PI3k/Akt signaling pathway, and Aβ-induced neuronal cell death in the cortex of Tg mice was markedly suppressed following treadmill exercise. These results suggest that treadmill exercise may be beneficial in preventing or treating Alzheimer's disease.
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Koo
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: In Su
authors.initials: IS
authors.lastname: Kwon
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: Eun Bum
authors.initials: EB
authors.lastname: Kang
authors.affiliation: Exercise Biochemistry Laboratory, Soon Chun Hyang University, Chungnam, Korea.
authors.forename: Chang Kuk
authors.initials: CK
authors.lastname: Lee
authors.affiliation: Exercise Biochemistry Laboratory, Dan Kook University, Seoul, Korea.
authors.forename: Nam Hee
authors.initials: NH
authors.lastname: Lee
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: Man Geun
authors.initials: MG
authors.lastname: Kwon
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: In Ho
authors.initials: IH
authors.lastname: Cho
authors.affiliation: Exercise Biochemistry Laboratory, Korea National Sport University, Seoul, Korea.
authors.forename: Joon Yong
authors.initials: JY
authors.lastname: Cho
keywords: Alzheimer’s disease; BDNF; Bcl-2/Bax ratio; COX-2; PI3k/Akt; neuronal cell death