title: Brief report: Endothelial colony-forming cells and inflammatory monocytes in HIV.
abstract: The relationships between HIV infection, monocyte activation, and endothelial colony-forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14 CD16), and nonclassical monocytes (CD14 CD16) levels in HIV-infected participants virologically suppressed on antiretroviral therapy, HIV-infected treatment-naive participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected virologically suppressed group compared with the uninfected controls. CD14 CD16 percentages (but not CD14 CD16 cells) were significantly higher in both HIV-infected groups vs. uninfected controls. In the HIV-infected groups, ECFCs and CD14 CD16 intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.
authors.affiliation: Departments of *Medicine; †Pediatrics, Indiana University School of Medicine, Indianapolis, IN; and ‡Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN (Case is now with Scripps Clinic Medical Group, Scripps Center for Organ & Cell Transplantation, La Jolla, CA).
authors.forename: Travis R
authors.initials: TR
authors.lastname: Hays
authors.forename: Julie A
authors.initials: JA
authors.lastname: Mund
authors.forename: Ziyue
authors.initials: Z
authors.lastname: Liu
authors.forename: Jamie
authors.initials: J
authors.lastname: Case
authors.forename: David A
authors.initials: DA
authors.lastname: Ingram
authors.forename: Samir K
authors.initials: SK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D002452:Cell Count; D003430:Cross-Sectional Studies; D066026:Endothelial Progenitor Cells / Q000502:physiology*; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011446:Prospective Studies; D055815:Young Adult