title: Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early- to intermediate-stage glottic carcinoma.
abstract: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC.
  
  
  
  We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer.
  
  
  
  Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used.
  
  
  
  Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space. © 2015 Wiley Periodicals, Inc. Head Neck 38: E333-E340, 2016.
authors.affiliation: Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Succo
authors.affiliation: Otorhinolaryngology Service, Martini Hospital, Turin, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Crosetti
authors.affiliation: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors.forename: Andy
authors.initials: A
authors.lastname: Bertolin
authors.affiliation: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lucioni
authors.affiliation: Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Caracciolo
authors.affiliation: L'altrastatistica srl, Consultancy and Training, Biostatistics Office, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Panetta
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors.forename: Andrea Elio
authors.initials: AE
authors.lastname: Sprio
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors.forename: Giovanni Nicolao
authors.initials: GN
authors.lastname: Berta
authors.affiliation: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rizzotto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: TNM staging; glottis cancer; laryngeal cancer; open partial laryngectomy; supracricoid partial laryngectomy; supratracheal partial laryngectomy