title: Disseminated gonococcal infection and eculizumab--a "high risk" connection?
abstract: A 28-year-old woman who was undergoing treatment with eculizumab for paroxysmal nocturnal hemoglobinuria presented to the hospital with fevers, chills, headache, and a swollen left index finger. Blood cultures returned positive for Neisseria gonorrhoeae. We report the second case of disseminated gonococcal infection associated with the use of eculizumab.
authors.affiliation: From the *Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus, OH; and †Sexual Health Clinic, Columbus Public Health, Columbus, OH.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Hublikar
authors.forename: William E
authors.initials: WE
authors.lastname: Maher
authors.forename: Jose A
authors.initials: JA
authors.lastname: Bazan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000009:adverse effects; D017963:Azithromycin / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D037001:Directive Counseling; D005260:Female; D006069:Gonorrhea / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification*; D012725:Sexual Behavior; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D061067:Antibodies, Monoclonal, Humanized; D002443:Ceftriaxone; D017963:Azithromycin; C481642:eculizumab