title: Nanoparticle-based targeted therapeutics in head-and-neck cancer.
abstract: Head-and-neck cancer is a major form of the disease worldwide. Treatment consists of surgery, radiation therapy and chemotherapy, but these have not resulted in improved survival rates over the past few decades. Versatile nanoparticles, with selective tumor targeting, are considered to have the potential to improve these poor outcomes. Application of nanoparticle-based targeted therapeutics has extended into many areas, including gene silencing, chemotherapeutic drug delivery, radiosensitization, photothermal therapy, and has shown much promise. In this review, we discuss recent advances in the field of nanoparticle-mediated targeted therapeutics for head-and-neck cancer, with an emphasis on the description of targeting points, including future perspectives.
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wu
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, China.
authors.forename: Shui-Hong
authors.initials: SH
authors.lastname: Zhou
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000628:therapy*; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D010789:Phototherapy
chemical_list: D004337:Drug Carriers
keywords: Nanoparticles; RNA interference; drug delivery; head-and-neck cancer; photothermal therapy; radiosensitization; targeted therapeutics