title: [Population pharmacokinetics and pharmacodynamics of clopidogrel in patients with acute coronary syndrome].
abstract: This study established a population pharmacokinetics-pharmacodynamics model of clopidogrel in patients with acute coronary syndrome. Fifty-nine patients were enrolled. The plasma concentration of clopidogrel active metabolite and vasodilator stimulated phosphoprotein platelet reactivity index (VASP-PRI) were selected as the pharmacokinetics index and the pharmacodynamics index, respectively. The covariates including demographic characteristics, laboratory indexes, combined medication, complications and genetic polymorphisms of related enzymes were screened for their influence on the pharmacokinetic and pharmacodynamics parameters. Population pharmacokinetic and pharmacodynamics data analysis was performed using NONMEM software. The general linear model and the indirectly effect model-turnover model for pharmacokinetic and pharmacodynamic analysis were selected as the basic model, respectively. The population typical values of K12, CL/F, V/F, EC50, K(in), and E(max) were 0.259 h(-1), 179 L x h(-1), 632 L, 1.57 ng x mL(-1), 4.29 and 0.664, respectively. CYP2C19 was the covariate in the final pharmacokinetic model, and the model was to design a prior dosage regimen.
authors.affiliation: Department of Pharmacy, First Affiliated  Hospital of Soochow University, Suzhou, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xie
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Ding
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Hang
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Miao
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism*; D000077144:Clopidogrel; D006801:Humans; D011110:Polymorphism, Genetic; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D000077144:Clopidogrel; D013988:Ticlopidine