title: Toxic Anterior Segment Syndrome following Phacoemulsification Secondary to Overdose of Intracameral Gentamicin.
abstract: Objective. To report a case of toxic anterior segment syndrome (TASS) that was caused by inadvertent anterior chamber and cornea stromal injection with high dose gentamicin following cataract surgery. Methods. Case report. Results. We report a 72-year-old female patient who developed TASS that was caused by high dose gentamicin (20 mg/0.5 mL), which was inadvertently used during the formation of the anterior chamber and hydration of the corneal incision. Unlike previous cases, hyphema and hemorrhagic fibrinous reaction were seen in the anterior chamber. Despite treatment, bullous keratopathy developed and penetrating keratoplasty was performed. The excised corneal button was sent for histopathological examination. Conclusions. Subconjunctival gentamicin is highly toxic to the corneal endothelium and anterior chamber structures. Including it on the surgical table carries a potentially serious risk for contamination of the anterior chamber.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Kafkas University, Merkez, 36100 Kars, Turkey.
authors.forename: Yaran
authors.initials: Y
authors.lastname: Koban
authors.affiliation: Department of Ophthalmology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, 34865 Istanbul, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Genc
authors.affiliation: Department of Ophthalmology, Hacettepe University Beytepe Health Center, 06800 Ankara, Turkey.
authors.forename: Gorkem
authors.identifier: 0000-0003-0995-0777
authors.initials: G
authors.lastname: Bilgin
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Kafkas University, Merkez, 36100 Kars, Turkey.
authors.forename: Halil Huseyin
authors.initials: HH
authors.lastname: Cagatay
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Kafkas University, Merkez, 36100 Kars, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Ekinci
authors.affiliation: Department of Pathology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, 34865 Istanbul, Turkey.
authors.forename: Melin
authors.initials: M
authors.lastname: Gecer
authors.affiliation: Kafkas University, 36100 Kars, Turkey.
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Yazar