title: The application of tribology in assessing texture perception of oral liquid medicines.
abstract: The palatability of medicines is likely to have a significant impact on patient adherence and consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowability (e.g. size, shape, texture). However, there has been limited work undertaken to measure the texture of medicines and how this may affect palatability and subsequent adherence. Tribology offers an understanding of oral processes and can allow physical properties of materials to be linked to "mouthfeel". This paper describes a preliminary application of tribology to oral liquid medicines and demonstrates that this technique is useful in the development of future oral liquid medicines.
authors.affiliation: Pharmacy and Therapeutics Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Medical School Building, University of Birmingham, Edgbaston, B15 2TT, United Kingdom. Electronic address: h.k.batchelor@bham.ac.uk.
authors.forename: Hannah
authors.initials: H
authors.lastname: Batchelor
authors.affiliation: School of Pharmacy, Hornbeam Building, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Venables
authors.affiliation: Pharmacy and Therapeutics Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Medical School Building, University of Birmingham, Edgbaston, B15 2TT, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Marriott
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
authors.forename: Tom
authors.initials: T
authors.lastname: Mills
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D055118:Medication Adherence; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D013649:Taste
chemical_list: D004364:Pharmaceutical Preparations
keywords: Medicine; Mouthfeel; Texture; Tribology