title: Design and evaluation of a nanoenhanced anti-infective calcium phosphate bone cements.
abstract: Post-operative complications due to infections are the most common problems that occur following dental and orthopedic implant surgeries and bone repair procedures. Preventing post-surgical infections is therefore a critical need that current polymethylmethacrylate (PMMA) bone cement fail to address. Calcium phosphate cements (CPCs) are unique in their ability to crystallize calcium and phosphate salts into hydroxyapatite (HA) and hence is naturally osteoconductive. Due to its low mechanical strength its use in implant fixation and bone repair is limited to non-load bearing applications. The present work describes a new and novel antibiotic-doped clay nanotube CPC composite with enhanced mechanical properties as well as sustained release properties.
authors.forename: Karthik K
authors.initials: KK
authors.lastname: Tappa
authors.forename: Udayabhanu M
authors.initials: UM
authors.lastname: Jammalamadaka
authors.forename: David K
authors.initials: DK
authors.lastname: Mills
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000538:Aluminum Silicates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D000077215:Clay; D065546:Drug Liberation; D004867:Equipment Design; D004926:Escherichia coli / Q000187:drug effects; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D019904:Polymethyl Methacrylate / Q000737:chemistry; D019736:Prostheses and Implants; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000538:Aluminum Silicates; D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; D006025:Glycosaminoglycans; D019904:Polymethyl Methacrylate; C020243:calcium phosphate; D000469:Alkaline Phosphatase; D000077215:Clay