title: P-stereogenic PNP pincer-Pd catalyzed intramolecular hydroamination of amino-1,3-dienes.
abstract: A new P-stereogenic PNP pincer-Pd complex was readily prepared from optically pure 2,6-bis[(boranato(tert-butyl)methylphosphino)methyl]pyridine. It was used in the asymmetric intramolecular hydroamination of amino-1,3-dienes, with the desired products being obtained in good yields and with excellent regioselectivities and up to moderate enantioselectivities. The absolute configuration of one of the hydroamination products was determined by X-ray crystallography studies. This simple and efficient procedure can be used for the synthesis of allyl-type chiral pyrrolidine derivatives.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. wanbin@sjtu.edu.cn.
authors.forename: Zehua
authors.initials: Z
authors.lastname: Yang
authors.forename: Chao
authors.initials: C
authors.lastname: Xia
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
authors.forename: Yangang
authors.initials: Y
authors.lastname: Liu
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugiya
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Imamoto
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D000588:Amines; D009942:Organometallic Compounds; D011725:Pyridines; D010165:Palladium