title: Deep vein thrombosis and pulmonary embolism after solid organ transplantation: an unresolved problem.
abstract: Venous thromboembolism (VTE) is a major complication after solid organ transplantation (SOT), with an incidence that ranges from 2 to 34%. Besides genetic risk factors such as inherited thrombophilia, other specific risk factors for VTE in SOT recipients include impairment of fibrinolysis produced by corticosteroids, in vitro procoagulant effects of calcineurin inhibitors, endothelial damage due to cytomegalovirus infection, and specific surgical factors. Prevention strategies have not been systematically studied. Therefore, it is mandatory for the international scientific community to conduct large, multicenter, randomized clinical trials to define strategies for the prevention of VTE in SOT recipients.
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: bsaez@vhebron.net.
authors.forename: Berta
authors.initials: B
authors.lastname: Sáez-Giménez
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Berastegui
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Karina
authors.initials: K
authors.lastname: Loor
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: López-Meseguer
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Monforte
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bravo
authors.affiliation: Hemostasis and thrombosis Unit, Department of Hematology, Hospital Univeristari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Santamaría
authors.affiliation: Pulmonology Service, Lung Transplant Program, Hospital Universitari Vall d'Hebrón, Passeig Vall d'Hebrón 119-129, 08035 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Roman
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents