title: Asymmetries in Cerebellar Plasticity and Motor Learning.
abstract: Synaptic plasticity at the parallel fiber to Purkinje cell synapse has long been considered a cellular correlate for cerebellar motor learning. Functionally, long-term depression and long-term potentiation at these synapses seem to be the reverse of each other, with both pre- and post-synaptic expression occurring in both. However, different cerebellar motor learning paradigms have been shown to be asymmetric and not equally reversible. Here, we discuss the asymmetric reversibility shown in the vestibulo-ocular reflex and eyeblink conditioning and suggest that different cellular plasticity mechanisms might be recruited under different conditions leading to unequal reversibility.
authors.affiliation: Department of Neurobiology, University of Chicago, Chicago, IL, 60637, USA. htitley@uchicago.edu.
authors.forename: Heather K
authors.initials: HK
authors.lastname: Titley
authors.affiliation: Department of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Hansel
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D011689:Purkinje Cells / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
keywords: Cerebellum; Eyeblink conditioning; Motor learning; Purkinje cells; Synaptic plasticity; Vestibulo-ocular reflex