title: The increasing value of plant-made proteins.
abstract: The production of high-value proteins in plants is maturing, as shown by the recent approval of innovative products and the latest studies that showcase plant-based production systems using technologies and approaches that are well established in other fields. These include host cell engineering, medium optimization, scalable unit operations for downstream processing (DSP), bioprocess optimization and detailed cost analysis. Product-specific benefits of plant-based systems have also been exploited, including bioencapsulation and the mucosal delivery of minimally processed topical and oral products with a lower entry barrier than pharmaceuticals for injection. Success stories spearheaded by the FDA approval of Elelyso developed by Protalix have revitalized the field and further interest has been fueled by the production of experimental Ebola treatments in plants.
authors.affiliation: Institute for Molecular Biotechnology, RWTH Aachen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Sack
authors.affiliation: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Hofbauer
authors.affiliation: Institute for Molecular Biotechnology, RWTH Aachen, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Aachen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Fischer
authors.affiliation: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria. Electronic address: eva.stoger@boku.ac.at.
authors.forename: Eva
authors.initials: E
authors.lastname: Stoger
mesh_terms: D000818:Animals; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010940:Plant Proteins / Q000096:biosynthesis* / Q000235:genetics; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering
chemical_list: D004364:Pharmaceutical Preparations; D010940:Plant Proteins