title: Synthesis and membrane-protective activity of novel derivatives of α-mangostin at the C-4 position.
abstract: A series of new C-4-derivatives of α-mangostin has been synthesized with the use of Mannich reaction and alkylation with 4-bromomethyl-2,6-dialkylphenols. It has been shown on a model of H2O2-induced erythrocyte hemolysis that the Mannich bases containing morpholinomethyl and piperidinomethyl fragments differ from parent α-mangostin by their high antioxidant and membrane-protective activity.
authors.affiliation: Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, 48, Pervomayskaya St., 167982 Syktyvkar, Komi Republic, Russian Federation. Electronic address: eugeneburavlev@gmail.com.
authors.forename: Evgeny V
authors.initials: EV
authors.lastname: Buravlev
authors.affiliation: Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, 28, Kommunisticheskaya St., 167982 Syktyvkar, Komi Republic, Russian Federation.
authors.forename: Oksana G
authors.initials: OG
authors.lastname: Shevchenko
authors.affiliation: Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, 48, Pervomayskaya St., 167982 Syktyvkar, Komi Republic, Russian Federation.
authors.forename: Aleksandr V
authors.initials: AV
authors.lastname: Kutchin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D029762:Garcinia mangostana / Q000737:chemistry; D051379:Mice; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D044004:Xanthones; C021053:mangostin
keywords: Aminomethylation; C-alkylation; Membrane-protective activity; Oxidative hemolysis; α-Mangostin