title: Barrier mechanisms in the Drosophila blood-brain barrier.
abstract: The invertebrate blood-brain barrier (BBB) field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance through G-protein coupled receptor signaling were the first demonstrations of the complex adaptive mechanisms of barrier physiology. Building upon this work, the integrity of the invertebrate BBB has recently been shown to require coordinated function of all layers of the compound barrier structure, analogous to signaling between the layers of the vertebrate neurovascular unit. These findings strengthen the notion that many BBB mechanisms are conserved between vertebrates and invertebrates, and suggest that novel findings in invertebrate model organisms will have a significant impact on the understanding of vertebrate BBB functions. In this vein, important roles in coordinating localized and systemic signaling to dictate organism development and growth are beginning to show how the BBB can govern whole animal physiologies. This includes novel functions of BBB gap junctions in orchestrating synchronized neuroblast proliferation, and of BBB secreted antagonists of insulin receptor signaling. These advancements and others are pushing the field forward in exciting new directions. In this review, we provide a synopsis of invertebrate BBB anatomy and physiology, with a focus on insights from the past 5 years, and highlight important areas for future study.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Hindle
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California, San Francisco San Francisco, CA, USA.
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Bainton
keywords: blood-brain barrier; chemoprotection; conserved physiology; drug delivery; invertebrates