title: UHMWPE-based nanocomposite as a material for damaged cartilage replacement.
abstract: In the present work dispersion-strengthened nanocomposites based on ultra-high molecular weight polyethylene (UHMWPE) after mechanical activation were studied. Mechanical activation was performed for hardening of the boundaries between the polymer particles, reducing the fusion defects and increasing of wear-resistance. Three types of samples were prepared: UHMWPE, UHMWPE/Al2O3 nanocomposite and UHMWPE/Al2O3 nanocomposite after mechanical activation. UHMWPE/Al2O3 nanocomposites prepared with mechanical activation show the best mechanical properties in compression and higher wear-resistance. UHMWPE/Al2O3 nanocomposites prepared with mechanical activation were chosen for in vivo study by orthotopical transplantation in rats. Animals' activity has been being monitored for 60days after surgery. No signs of inflammation, cellular infiltration, destruction of material or bone-cartilage defect were found. Implanted sample has not changed its position of implantation, there were no any shifts. Obtained data shows that UHMWPE-based nanocomposite is a promising material for creating bioimplants for cartilage defect replacement.
authors.affiliation: National University of Science and Technology "MISIS", 119049, Leninskiy pr. 4, Moscow, Russian Federation. Electronic address: Senatov@misis.ru.
authors.forename: F S
authors.initials: FS
authors.lastname: Senatov
authors.affiliation: N.N. Blokhin Russian Cancer Research Center, 115478, Kashirskoye sh. 23, Moscow, Russian Federation.
authors.forename: A N
authors.initials: AN
authors.lastname: Kopylov
authors.affiliation: N.N. Blokhin Russian Cancer Research Center, 115478, Kashirskoye sh. 23, Moscow, Russian Federation.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Anisimova
authors.affiliation: N.N. Blokhin Russian Cancer Research Center, 115478, Kashirskoye sh. 23, Moscow, Russian Federation.
authors.forename: M V
authors.initials: MV
authors.lastname: Kiselevsky
authors.affiliation: National University of Science and Technology "MISIS", 119049, Leninskiy pr. 4, Moscow, Russian Federation.
authors.forename: A V
authors.initials: AV
authors.lastname: Maksimkin
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002356:Cartilage / Q000378:metabolism* / Q000473:pathology; D050724:Fractures, Cartilage / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008297:Male; D053761:Nanocomposites / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D000537:Aluminum Oxide
keywords: Cartilage regeneration; Implant; Knee joint; Polymer composite; Ultra-high molecular weight polyethylene; Wear-resistance