title: Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship.
abstract: As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.
authors.forename: Takao
authors.initials: T
authors.lastname: Shimayoshi
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Mishima
authors.forename: Akira
authors.initials: A
authors.lastname: Amano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D016014:Linear Models; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D013318:Stroke Volume; D017725:Ventricular Pressure