title: Blood pressure and intracranial aneurysms in autosomal dominant polycystic kidney disease.
abstract: OBJECTIVE
  Autosomal dominant polycystic kidney disease (ADPKD) is correlated with an increased frequency of both intracranial aneurysms (ICANs), and arterial hypertension (AH). The aim of our study was to search for the association between blood pressure (BP) and ICANs in ADPKD patients.
  
  
  METHODS
  Sixty-eight adult, pre-dialysis phase ADPKD patients underwent both screening for ICANs with magnetic resonance angiography of the brain, and ambulatory blood pressure monitoring (ABPM).
  
  
  RESULTS
  ICANs were diagnosed in 10 patients (ICAN+ group), while in 58 were not (ICAN- group). The nighttime maximum diastolic blood pressure (DBP), maximum increase in DBP from measurement to measurement (positive delta of DBP) at night, and the standard deviation of the daytime mean arterial pressure were significantly higher in ICAN+ compared to ICAN- patients. Additionally, in a subgroup of patients after 45 years-of-age, ICAN+ patients had significantly higher maximum 24-hour and daytime systolic blood pressure, maximum 24-hour, daytime, nighttime DBP, maximum daytime and nighttime positive delta of DBP compared to ICAN- cases.
  
  
  CONCLUSIONS
  Development of ICANs in hypertensive ADPKD patients is accompanied with higher values of some BP parameters measured by ABPM. Hypertensive ADPKD patients with substantial fluctuations in BP assessed by ABPM, especially those after 45 years-of-age, should become candidates for screening for ICANs.
authors.affiliation: Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Niemczyk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pilecki
authors.forename: Monika
authors.initials: M
authors.lastname: Gradzik
authors.forename: Maciej
authors.initials: M
authors.lastname: Bujko
authors.forename: Stanisław
authors.initials: S
authors.lastname: Niemczyk
authors.forename: Leszek
authors.initials: L
authors.lastname: Pączek
mesh_terms: D000328:Adult; D000368:Aged; D062186:Arterial Pressure; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002533:Cerebral Angiography; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications; D002532:Intracranial Aneurysm / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000503:physiopathology; D055815:Young Adult