title: Development of an online, publicly accessible naive Bayesian decision support tool for mammographic mass lesions based on the American College of Radiology (ACR) BI-RADS lexicon.
abstract: OBJECTIVE
  To develop and validate a decision support tool for mammographic mass lesions based on a standardized descriptor terminology (BI-RADS lexicon) to reduce variability of practice.
  
  
  METHODS
  We used separate training data (1,276 lesions, 138 malignant) and validation data (1,177 lesions, 175 malignant). We created naïve Bayes (NB) classifiers from the training data with tenfold cross-validation. Our "inclusive model" comprised BI-RADS categories, BI-RADS descriptors, and age as predictive variables; our "descriptor model" comprised BI-RADS descriptors and age. The resulting NB classifiers were applied to the validation data. We evaluated and compared classifier performance with ROC-analysis.
  
  
  RESULTS
  In the training data, the inclusive model yields an AUC of 0.959; the descriptor model yields an AUC of 0.910 (P < 0.001). The inclusive model is superior to the clinical performance (BI-RADS categories alone, P < 0.001); the descriptor model performs similarly. When applied to the validation data, the inclusive model yields an AUC of 0.935; the descriptor model yields an AUC of 0.876 (P < 0.001). Again, the inclusive model is superior to the clinical performance (P < 0.001); the descriptor model performs similarly.
  
  
  CONCLUSIONS
  We consider our classifier a step towards a more uniform interpretation of combinations of BI-RADS descriptors. We provide our classifier at www.ebm-radiology.com/nbmm/index.html .
  
  
  CONCLUSIONS
  • We provide a decision support tool for mammographic masses at www.ebm-radiology.com/nbmm/index.html . • Our tool may reduce variability of practice in BI-RADS category assignment. • A formal analysis of BI-RADS descriptors may enhance radiologists' diagnostic performance.
authors.affiliation: Department of Radiology, University Hospital Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany, matthias.benndorf@uniklinik-freiburg.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Benndorf
authors.forename: Elmar
authors.initials: E
authors.lastname: Kotter
authors.forename: Mathias
authors.initials: M
authors.lastname: Langer
authors.forename: Christoph
authors.initials: C
authors.lastname: Herda
authors.forename: Yirong
authors.initials: Y
authors.lastname: Wu
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Burnside
mesh_terms: D000328:Adult; D000368:Aged; D001499:Bayes Theorem; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D020000:Decision Support Systems, Clinical / Q000592:standards*; D005260:Female; D006801:Humans; D020407:Internet; D008327:Mammography / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D012372:ROC Curve; D011871:Radiology / Q000193:education; D009626:Terminology as Topic; D014481:United States