title: Panel sequencing melanomas.
abstract: Sequencing samples of melanoma for targetable mutations has become a standard of care for metastatic disease. In this issue, Siroy et al. demonstrate how clinical genetic analysis is moving from a single-gene Sanger-sequencing approach to targeted next-generation sequencing. They present data on a large cohort of patients with advanced melanoma, and their data support previous findings and also present novel aspects of melanoma genetics.
authors.affiliation: West German Cancer Center, Department of Dermatology, University Hospital Essen, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany. Electronic address: Klaus.Griewank@uk-essen.de.
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Griewank
authors.affiliation: West German Cancer Center, Department of Dermatology, University Hospital Essen, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Schadendorf
mesh_terms: D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf