title: Model based non-invasive estimation of PV loop from echocardiography.
abstract: We introduce a model-based approach for the non-invasive estimation of patient specific, left ventricular PV loops. A lumped parameter circulation model is used, composed of the pulmonary venous circulation, left atrium, left ventricle and the systemic circulation. A fully automated parameter estimation framework is introduced for model personalization, composed of two sequential steps: first, a series of parameters are computed directly, and, next, a fully automatic optimization-based calibration method is employed to iteratively estimate the values of the remaining parameters. The proposed methodology is first evaluated for three healthy volunteers: a perfect agreement is obtained between the computed quantities and the clinical measurements. Additionally, for an initial validation of the methodology, we computed the PV loop for a patient with mild aortic valve regurgitation and compared the results against the invasively determined quantities: there is a close agreement between the time-varying LV and aortic pressures, time-varying LV volumes, and PV loops.
authors.forename: Lucian
authors.initials: L
authors.lastname: Itu
authors.forename: Puneet
authors.initials: P
authors.lastname: Sharma
authors.forename: Bogdan
authors.initials: B
authors.lastname: Georgescu
authors.forename: Ali
authors.initials: A
authors.lastname: Kamen
authors.forename: Constantin
authors.initials: C
authors.lastname: Suciu
authors.forename: Dorin
authors.initials: D
authors.lastname: Comaniciu
mesh_terms: D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008955:Models, Cardiovascular; D012044:Regression Analysis; D013318:Stroke Volume; D014463:Ultrasonography; D017725:Ventricular Pressure