title: PfEMP1's magical embrace of EPCR.
abstract: Since discovering PfEMP1 virulence proteins in Plasmodium falciparum, malariologists have struggled to reconcile their limitless sequence diversity with their binding to relatively few host receptors. In this issue of Cell Host & Microbe, Lau et al. (2015) explore how diverse PfEMP1s embrace EPCR, promoting parasite survival and killing African children.
authors.affiliation: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Room 3E-10A, Rockville, MD 20852, USA. Electronic address: rfairhurst@niaid.nih.gov.
authors.forename: Rick M
authors.initials: RM
authors.lastname: Fairhurst
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D005260:Female; D014644:Genetic Variation; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface