title: Response to targeted therapy in urachal adenocarcinoma.
abstract: We report the case of a young woman diagnosed with metastatic urachal carcinoma. A multimodal approach was used for the management of this patient. Due to disease progression despite surgery and two different chemotherapy regimens (neoadjuvant capecitabine + irinotecan + oxaliplatin and docetaxel + cisplatin after surgery), treatment with sunitinib was eventually started. Treatment with sunitinib resulted in stable disease and improvement of symptoms. Sunitinib was discontinued due to the occurrence of metrorrhagia, and restarted one week later. Disease eventually progressed and the patient died 18 months after the onset of symptoms. This is the first report on the use of sunitinib for the management of urachal carcinoma and provides initial evidence supporting the use of targeted therapy in this setting.
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Testa
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Verzoni
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Grassi
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Colecchia
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Filomena
authors.initials: F
authors.lastname: Panzone
authors.affiliation: Istituto Nazionale Tumori , Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Procopio
keywords: sunitinib; targeted therapies; urachal adenocarcinoma