title: A mock circulatory loop for designing and evaluating total artificial hearts.
abstract: A mock circulatory loop was constructed to facilitate total artificial heart development. The loop includes many novel features such as a pressure-regulated tank to simulate exercise conditions, controllable systemic and pulmonary vascular resistance to create left-right flow imbalances as seen in postural change and breathing, and a left atrial suction valve. Dual HeartMate II pumps and the BiVACOR® rotary total artificial heart were used to generate pressure and flow data characterizing the flow loop.
authors.forename: Holley C
authors.initials: HC
authors.lastname: Love
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Timms
authors.forename: Frank
authors.initials: F
authors.lastname: Nestler
authors.forename: O H
authors.initials: OH
authors.lastname: Frazier
authors.forename: William E
authors.initials: WE
authors.lastname: Cohn
mesh_terms: D015444:Exercise; D006325:Heart Atria; D006354:Heart, Artificial; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D014655:Vascular Resistance