title: Concurrent occurrence of renal cell carcinoma with rhabdoid features in a married couple: a case report.
abstract: BACKGROUND
  Renal cell carcinoma (RCC) with rhabdoid features is a rare histology and exhibits clinically aggressive behavior. We report a case of a married couple in whom RCC with rhabdoid features concurrently occurred. The rarity of this event suggests that environmental factors may contribute to the etiology of RCC with rhabdoid features.
  
  
  METHODS
  A 76-year-old Japanese woman was diagnosed with a hypervascular mass in the right kidney and tumor thrombus extending into the right atrium by enhanced computed tomography (CT). She underwent radical nephrectomy and tumor thrombectomy following systemic therapy with the tyrosine kinase inhibitor sunitinib. The histological evaluation denoted clear cell RCC with rhabdoid features. The patient died of cancer 12 months postoperatively. A 76-year-old man, her husband, presented with gross hematuria 2 weeks after his wife had undergone surgery. He had a long history of asbestos exposure. An abdominal CT scan revealed a hypervascular mass in the right kidney and tumor thrombus extending into the inferior vena cava. He also underwent radical nephrectomy and tumor thrombectomy. The histological evaluation also showed clear cell RCC with rhabdoid features. Bone metastasis occurred 12 months postoperatively, but he died of an unrelated cause 18 months after surgery.
  
  
  CONCLUSIONS
  Concurrent occurrence of RCC with rhabdoid features may not to be coincidental. Although further studies are warranted, asbestos exposure may contribute to the etiology of clear cell RCC with rhabdoid features.
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. ryu-matsumoto@amber.plala.or.jp.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Matsumoto
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. nozomis@mbj.nifty.com.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shinohara
authors.affiliation: Department of Pathology, Hokkaido University Hospital, North-14, West-5, Sapporo, Japan. kyanack@huhp.hokudai.ac.jp.
authors.forename: Kanako
authors.initials: K
authors.lastname: C-Hatanaka
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan. kurochankochi@yahoo.co.jp.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. kunihiko.tsuchiya@gmail.com.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. maruyama_satoru@ybb.ne.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Maruyama
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. takataka@rf6.so-net.ne.jp.
authors.forename: Takashige
authors.initials: T
authors.lastname: Abe
authors.affiliation: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Sapporo, Japan. k-nonno@med.hokudai.ac.jp.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nonomura
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D005191:Family Characteristics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008393:Marriage; D018335:Rhabdoid Tumor / Q000473:pathology*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed