title: Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicola.
abstract: Twelve new chromone derivatives, corynechromones A-L (1-12), were isolated from the sponge-derived fungus Corynespora cassiicola XS-200900I7. Among them, 1/2, 3/4, 5/6, and 7/8 were pairs of epimers. The planar structures were determined by extensive NMR spectroscopic data. The absolute configurations of 1-10 were assigned by the modified Mosher's method and TDDFT ECD calculations together with comparison of their CD spectra. These are the first chromone derivatives reported from the genus Corynespora. A possible rule to determine the absolute configurations at C-2 in chromone derivatives by CD was proposed.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, and §Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003, People's Republic of China.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Zhao
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Li-She
authors.initials: LS
authors.lastname: Gan
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D001409:Bacillus cereus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D057219:Biofouling / Q000517:prevention & control; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056569:Enterococcaceae / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology*; D016958:Pseudomonas putida / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013237:Stereoisomerism; D059004:Topoisomerase I Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014733:Vibrio / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D002867:Chromones; D059004:Topoisomerase I Inhibitors