title: Visceral Adiposity Index and pattern of dyslipidaemia at different stages of glucose intolerance-A study from India.
abstract: OBJECTIVE
  To see the pattern of dyslipidaemia and Visceral Adiposity Index (VAI) at different stages of glucose intolerance in Indian population.
  
  
  METHODS
  Data of 600 subjects were considered for this analysis. Waist circumference and BMI were recorded. OGTT and lipid profile were done. Subjects were divided into three groups; Group 1 (Normoglycaemic), Group 2 (Prediabetes) and Group 3 (new DM). Subjects having one or more lipid parameters outside the targets recommended by ADA were considered to have dyslipidaemia. VAI, a sex-specific index, was calculated.
  
  
  RESULTS
  LDL-C was the most common isolated single abnormality (84.5%), followed by HDL-C (58.7%) and triglycerides (49.7%) among the total subjects. 73% had high LDL-C and 56% had low HDL-C even in normoglycaemic subjects. LDL-C abnormality was similar in prediabetes and diabetes. Commonest combination of two abnormalities was seen mainly with LDL-C and HDL-C. Mean VAI increased at different stages of glucose intolerance and VAI≥2.3 gave sensitivity of 61.2% and specificity of 59.7% to detect glucose intolerance.
  
  
  CONCLUSIONS
  The most common single lipid abnormality was high LDL-C. Combination of two abnormalities was seen with LDL-C and HDL-C. VAI increased at different stages of glucose intolerance. These findings may be useful for targeting high-risk population.
authors.affiliation: M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre [WHO Collaborating Centre for Research, Education and Training in Diabetes], No. 5, Main Road, Royapuram, Chennai 600013, Tamil Nadu, India.
authors.forename: Satyavani
authors.initials: S
authors.lastname: Kumpatla
authors.forename: Clementina
authors.initials: C
authors.lastname: Michael
authors.forename: Vijay
authors.initials: V
authors.lastname: Viswanathan
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000503:physiopathology*; D050171:Dyslipidemias / Q000503:physiopathology*; D005260:Female; D018149:Glucose Intolerance / Q000503:physiopathology*; D006801:Humans; D007194:India; D007333:Insulin Resistance; D008297:Male; D056128:Obesity, Abdominal / Q000503:physiopathology*