title: Interleukin 17A and interleukin 17F polymorphisms are associated with oral squamous cell carcinoma susceptibility in a Chinese population.
abstract: OBJECTIVE
  Several studies have investigated the association of the interleukin (IL) 17A and IL-17F polymorphisms and cancer of various organs. However, the role of the IL-17A and IL-17F polymorphisms in oral squamous cell carcinoma (OSCC) remains unclear. Thus we sought to clarify the association of the rs2275913, rs763780, and rs2397084 polymorphisms with OSCC in a Chinese population.
  
  
  METHODS
  A TaqMan single-nucleotide polymorphism Genotyping Assay (ABI, Foster, CA) was used to measure the distributions of the IL-17A (rs2275913) and IL-17F (rs763780, rs2397084) polymorphisms in 121 OSCC patients and 103 healthy controls. The association of those polymorphisms and clinical OSCC patient characteristic also was evaluated.
  
  
  RESULTS
  Individuals carrying the rs2275913 A allele and AA genotype had an increased risk of OSCC (odds ratio [OR], 1.463; 95% confidence interval [CI], 0.807 to 2.652; and OR, 2.713; 95% CI, 1.250 to 5.889, respectively). The frequency of the rs2397084 T allele was significantly associated with a higher risk of OSCC than the G allele (OR, 1.501; 95% CI, 1.026 to 2.196). No difference in rs763780 frequencies was observed. The rs2275913 AA and rs2397084 TT genotypes also were associated with late clinical stages and poor tumor differentiation. In addition, stratification analysis indicated that the rs2275913 AA genotype increased OSCC risk among smoking and drinking populations (OR, 4.000; 95% CI, 1.404 to 11.394; and OR, 3.500; 95% CI, 1.018 to 12.030, respectively). In a smoking population, an rs9382084 T-allele carrier has a greater potential risk of OSCC than the overall population (OR, 2.200; 95% CI, 1.009 to 4.797).
  
  
  CONCLUSIONS
  The results of this study suggest a significant association of rs2275913 and rs2397084 but not rs763780 with OSCC risk, and this was related to tumor stage and differentiation. In addition, the IL-17A and IL-17F polymorphisms can interact with smoking and drinking to enhance the risk of OSCC developing.
authors.affiliation: Department of Stomatology, PetroChemical General Hospital of Lanzhou, Gansu, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Stomatology, Shihua General Hospital of Lanzhou, Gansu, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, Shihua General Hospital of Lanzhou, Gansu, China.
authors.forename: Zhaoquan
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Stomatology, General Hospital of Lanzhou Area Command of Chinese PLA, Gansu, China.
authors.forename: Lilu
authors.initials: L
authors.lastname: Bai
authors.affiliation: Dental Hospital of Medical School, Northwest University for Nationalities, Gansu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Nie
authors.affiliation: Department of Stomatology, Gansu Second People's Hospital, Gansu, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Stomatology, Shihua General Hospital of Lanzhou, Gansu, China. Electronic address: xuhxoral@163.com.
authors.forename: Huanxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D020381:Interleukin-17