title: Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status.
abstract: The prevalence of gestational diabetes mellitus (GDM) is increasing because of the worldwide obesity/diabetes epidemic. The complications of untreated GDM affect both the mother and baby and include complications during pregnancy as well as increased risk of subsequent type-2 diabetes in mothers and offspring. Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (HbA1c), are currently not recommended for GDM screening. Instead, an oral glucose tolerance test is specified, which is invasive, time-consuming, and not easily accessible to many at-risk populations. In this study, we describe a multi-analyte maternal serum profile test that incorporates novel glycoprotein biomarkers and previously described GDM-associated markers. In screening for GDM by multi-analyte panel, the detection rate was 87% at a false-positive rate of 1%.
authors.affiliation: DiabetOmics Inc, Beaverton, Oregon, USA.
authors.forename: Srinivasa R
authors.initials: SR
authors.lastname: Nagalla
authors.affiliation: DiabetOmics Inc, Beaverton, Oregon, USA.
authors.forename: Caryn K
authors.initials: CK
authors.lastname: Snyder
authors.affiliation: DiabetOmics Inc, Beaverton, Oregon, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Michaels
authors.affiliation: DiabetOmics Inc, Beaverton, Oregon, USA.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Laughlin
authors.affiliation: Oregon Health and Science University, Portland, Oregon, USA.
authors.forename: Charles T
authors.initials: CT
authors.lastname: Roberts
authors.affiliation: Dr. V. Seshiah Diabetes Care and Research Institute, Chennai, Tamil Nadu, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Balaji
authors.affiliation: Dr. V. Seshiah Diabetes Care and Research Institute, Chennai, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Balaji
authors.affiliation: Dr. V. Seshiah Diabetes Care and Research Institute, Chennai, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Seshiah
authors.affiliation: Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Hyderabad, Telangana, India.
authors.forename: Paturi V
authors.initials: PV
authors.lastname: Rao
keywords: Gestational diabetes; glycosylated fibronectin; maternal serum biomarker