title: Celiac disease: 10-year experience in a Romanian tertiary center.
abstract: OBJECTIVE
  To evaluate the experience of a single coeliac center over a 10-year-observational period.
  
  
  METHODS
  Between January 2003 and December 2013 a total of 195 consecutive patients admitted with celiac disease were tested by multiple duodenal biopsies, anti-tissue transglutaminase and anti-gliadin antibodies, and baseline demographic, clinical, biological and immunological parameters.
  
  
  RESULTS
  Patients were divided into two major groups according to the clinical features and number of signs and symptoms present upon admission: gastrointestinal (131, 67.17%) and non-gastrointestinal (64, 32.8%). Anti-tissue transglutaminase and anti-gliadin antibodies showed seropositivity in 109/158. Histological samples were available in 152 cases, according to Marsh-Oberhuber classification 11.18% being type 0, 17.76%, type I-II, and 71.05% type III. Correlations between anti-tissue transglutaminase antibody titers and Marsh-Oberhuber classification were found to be statistically significant. Body mass index was available in 96 cases. We found that severe atrophy was predominant in patients with a BMI<18 kg/m2.
  
  
  CONCLUSIONS
  Celiac disease has an increasing prevalence and can be diagnosed at any age. Histology samples were indicative of different stages of villous atrophy. The disease prevalence is significantly higher among women. There was no statistically significant correlation between Marsh classification and BMI values.
authors.affiliation: University of Medicine and Pharmacy Grigore T. Popa - Iaşi, Department of Medical Specialties (I).
authors.forename: Roxana
authors.initials: R
authors.lastname: Maxim
authors.forename: Alina
authors.initials: A
authors.lastname: Pleşa
authors.forename: Irina
authors.initials: I
authors.lastname: Ciortescu
authors.forename: Irina
authors.initials: I
authors.lastname: Gîrleanu
authors.forename: Oana
authors.initials: O
authors.lastname: Stoica
authors.forename: Anca-Victoriţa
authors.initials: AV
authors.lastname: Trifan
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D015992:Body Mass Index; D002446:Celiac Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D019204:GTP-Binding Proteins / Q000097:blood*; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007155:Immunologic Factors / Q000097:blood*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D011503:Transglutaminases / Q000097:blood*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D007070:Immunoglobulin A; D007155:Immunologic Factors; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins