title: Acridone-based antitumor agents: a mini-review.
abstract: In the past decades, tricyclic acridone ring system has become one of the major research interests of the medicinal chemists due to the biological significance of this moiety in drug design and drug discovery. Acridone scaffold has substantial bio-potential since it possess crucial activities such as antibacterial, antimalarial, antiviral and anti-neoplastic. The diverse biological activity of acridone and its prospective in reversal of multi-drug resistance has attracted attention of medicinal chemists to explore this scaffold especially to treat multi-drug resistance in cancer. Considering this potential in this review we have summarized the synthesis and the antitumor activities of different acridone derived compounds reported from 2000 to 2014.
authors.forename: Wesam S
authors.initials: WS
authors.lastname: Alwan
authors.affiliation: Sinhgad Institute of Pharmacy, Narhe, Pune - 411041, affiliated to University of Pune, India. anand_mahajan@yahoo.com.
authors.forename: Anand A
authors.initials: AA
authors.lastname: Mahajan
authors.forename: Rajesh A
authors.initials: RA
authors.lastname: Rane
authors.forename: Anish A
authors.initials: AA
authors.lastname: Amritkar
authors.forename: Shital S
authors.initials: SS
authors.lastname: Naphade
authors.forename: Mayur C
authors.initials: MC
authors.lastname: Yerigiri
authors.forename: Rajshekhar
authors.initials: R
authors.lastname: Karpoormath
mesh_terms: D000166:Acridines / Q000737:chemistry*; D054831:Acridones; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D015195:Drug Design; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000166:Acridines; D054831:Acridones; D000970:Antineoplastic Agents; C041300:acridone