title: Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae).
abstract: Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, TWAS Research Unit, University of Yaoundé 1, P. O. Box 812, Yaoundé, Cameroon.
authors.forename: Rosine Fotsing
authors.initials: RF
authors.lastname: Ngamgwe
authors.affiliation: Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland.
authors.forename: Raoul
authors.initials: R
authors.lastname: Yankam
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon.
authors.forename: Jean Rodolphe
authors.initials: JR
authors.lastname: Chouna
authors.affiliation: Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Lanz
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Berne, Switzerland.
authors.forename: Julien
authors.initials: J
authors.lastname: Furrer
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Berne, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Schürch
authors.affiliation: Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland. ; University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.affiliation: Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon.
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.affiliation: Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland.
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.affiliation: Department of Organic Chemistry, Faculty of Science, TWAS Research Unit, University of Yaoundé 1, P. O. Box 812, Yaoundé, Cameroon.
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.affiliation: Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Brenneisen
keywords: Antiparasitic activity; Omphalocarpum procerum; Procerenone; Sapotaceae; Triterpenoid