title: Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide.
abstract: Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and (1) H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release-by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.
authors.affiliation: College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P.R. China; Chonbuk National University, School of Semiconductor and Chemical Engineering, Baekjero 567, Deokjin-gu, Jeonju, Jeonbuk, 561-756, Republic of Korea; Islamic Azad University, Omidiyeh Branch, Department of Polymer, 63731-93719, Omidiyeh, Iran; Department of Chemistry, University of North Carolina at Chapel Hill, North Carolina, 27599-3290, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Vatankhah-Varnoosfaderani
authors.forename: Amin
authors.initials: A
authors.lastname: GhavamiNejad
authors.forename: Saud
authors.initials: S
authors.lastname: Hashmi
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Stadler
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry; D004396:Coloring Agents / Q000378:metabolism; D004058:Diffusion; D065546:Drug Liberation; D005070:Evans Blue / Q000378:metabolism; D005782:Gels; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000178:Acrylamides; D002396:Catechols; D004396:Coloring Agents; D005782:Gels; D011108:Polymers; D012997:Solvents; D005070:Evans Blue; C067295:N-isopropylacrylamide; C034221:catechol
keywords: catechol; drug release; hydrogen bonding; mussel-inspired; self-healing