title: Intraoperative full-dose of partial breast irradiation with electrons delivered by standard linear accelerators for early breast cancer.
abstract: Purpose. To assess feasibility, efficacy, toxicity, and cosmetic results of intraoperative radiotherapy (IORT) with electrons delivered by standard linear accelerators (Linacs) during breast conserving surgeries for early infiltrating breast cancer (BC) treatment. Materials and Methods. A total of 152 patients with invasive ductal carcinoma (T ≤ 3.0 cm) at low risk for local relapses were treated. All had unicentric lesions by imaging methods and negative sentinel node. After a wide local excision, 21 Gy were delivered on the parenchyma target volume with electron beams. Local recurrences (LR), survival, toxicity, and cosmetic outcomes were analyzed. Results. The median age was 58.3 years (range 40-85); median follow-up was 50.7 months (range 12-101.5). There were 5 cases with LR, 2 cases with distant metastases, and 2 cases with deaths related to BC. The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively. Complications were rare, and the cosmetic results were excellent or good in most of the patients. Conclusions. IORT with electrons delivered by standard Linacs is feasible, efficient, and well tolerated and seems to be beneficial for selected patients with early infiltrating BC.
authors.affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil ; LIM 02, Discipline of Human Structural Topography, University of São Paulo Medical School, Avenida Dr. Arnaldo 455, 01246-903 São Paulo, SP, Brazil.
authors.forename: Alfredo Carlos S D
authors.initials: AC
authors.lastname: Barros
authors.affiliation: Department of Radiotherapy, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Hanna
authors.affiliation: Department of Radiotherapy, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil ; Radiotherapy Service, Hospital das Clínicas, University of São Paulo Medical School, Rua Dr. Enéas de Carvalho Aguiar 225, 05403-000 São Paulo, SP, Brazil.
authors.forename: Heloísa A
authors.initials: HA
authors.lastname: Carvalho
authors.affiliation: Hospital Perola Byington, Avenida Brigadeiro Luís Antônio 683, 01317-000 São Paulo, SP, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martella
authors.affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil.
authors.forename: Felipe Eduardo M
authors.initials: FE
authors.lastname: Andrade
authors.affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil.
authors.forename: José Roberto M
authors.initials: JR
authors.lastname: Piato
authors.affiliation: Mastology Center, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, 01308-050 São Paulo, SP, Brazil.
authors.forename: José Luiz B
authors.initials: JL
authors.lastname: Bevilacqua