title: [Comparative study of different methods of blood purification treatment of paraquat intoxication].
abstract: OBJECTIVE
  To investigate the different effect of three methods of blood purification for paraquat poisoning patients:hemoperfusion (HP), hemoperfusion combined with hemodialysis (HP + HD), hemoperfusion combined with continuous veno-venous hemofiltration (HP + CVVH).
  
  
  METHODS
  72 cases of paraquat poisoning patients were divided into three groups after giving conventional therapy HP group, HP + HD group, HP + CVVH group. Compared the rate of decline concentrations of paraquat in blood, the liver and the kidney damage between before and after blood purification and contrast the mortality in three groups after different method of blood purification.
  
  
  RESULTS
  The rate of decline concentrations of paraquat in blood of the HP + HD group and HP + CVVH group were both significantly greater than the HP group, but this result of HP + HD group has no significant difference compared with HP + CVVH group; Among the three groups of patients after 72 hours, the degree of dysfunction of liver of the HP + HD group and HP + CVVH group were both significantly lower than the HP group, whilely the degree of dysfunction of kidney of the HP + HD group was significantly lower than the HP group and the HP + CVVH group. The survival time of the HP + HD group and the HP + CVVH group were significant linger than the HP group, but the comparison among the three groups had no significant difference in mortality.
  
  
  CONCLUSIONS
  Three blood purification methods can effectively remove paraquat absorbed into the blood, and the hemoperfusion combined with hemodialysis or continuous veno-venous hemofiltration can effectively reduce the degree of damage of liver and kidney and also can prolong survival time, but did not significantly improve the survival rate of patients.
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Jixue
authors.initials: J
authors.lastname: Shi
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Qingbin
authors.initials: Q
authors.lastname: Tang
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Yuelei
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: The Emergency Department of Affiliated Hospital of Taishan Medical University, Taian 271000, China.
authors.forename: Xianjing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D006440:Hemofiltration / Q000379:methods*; D006464:Hemoperfusion; D006801:Humans; D007668:Kidney; D008099:Liver; D010269:Paraquat / Q000097:blood / Q000633:toxicity*; D006435:Renal Dialysis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D010269:Paraquat