title: Tandem Synthesis of 3-chloro-4-iodoisoxazoles from 1-copper(I) alkynes, dichloroformaldoxime, and molecular iodine.
abstract: A tandem synthesis for structurally novel 3-chloro-4-iodoisoxazoles was developed by simply mixing 1-copper(I) alkynes, dichloroformaldoxime, and molecular iodine together. The combination of 1-copper(I) alkyne and molecular iodine was well used as a synthetic equivalent of 1-iodoalkyne without the need for tedious preparation, purification, and storage of 1-iodoalkyne.
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Jianlan
authors.initials: J
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Zhouxing
authors.initials: Z
authors.lastname: Zhao
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006843:Hydrocarbons, Chlorinated; D007555:Isoxazoles; D009942:Organometallic Compounds; D010091:Oximes; C000598299:dichloroformaldoxime; D003300:Copper; D007455:Iodine