title: [Clinicopathologic features of collagen III glomerulopathy].
abstract: OBJECTIVE
  To study the clinicopathologic features of collagen III glomerulopathy and its cause, pathogenesis and prognosis.
  
  
  METHODS
  Five cases of collagen III glomerulopathy that collected from 2005 to 2014 were observed by renal biopsy. The morphologic characteristics were studied by light microscopy, immunofluorescence, immunohistochemical and electron microscopy.
  
  
  RESULTS
  The glomerular mesangium became expansion but no hypercellularity, basement membrane appeared thickened. The glomeruli showed collagen type III deposit by immunohistochemistry method, and collagen fibers increased by electron microscopy. The patients often show serious proteinuria, nephrotic syndrome and renal function damage.
  
  
  CONCLUSIONS
  Collagen III glomerulopathy is an idiopathic glomerular disease, characterized by massive accumulation of collagen type III within the glomerular mesangial areas and basement membrane. Collagen III glomerulopathy is extremely rare. The etiology and pathogenesis may relate to the abnormality of collagen III gene. There is no specific treatment for it and its prognosis is poor.
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Haijing
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Shenglan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China. E-mail: cliff_ZOU@sina.com.
authors.forename: Wanzhong
authors.initials: W
authors.lastname: Zou
mesh_terms: D001485:Basement Membrane / Q000378:metabolism; D001706:Biopsy; D024061:Collagen Type III / Q000235:genetics / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology*; D008854:Microscopy, Electron; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis
chemical_list: D024061:Collagen Type III