title: Conventional US, elastography, and contrast enhanced US features of papillary thyroid microcarcinoma predict central compartment lymph node metastases.
abstract: Lymph node metastases at the time of diagnosis have a major impact on both therapeutic strategy and tumor recurrence for patients with papillary thyroid microcarcinoma (PTMC). Our objective was to evaluate the usefulness of PTMC characteristics on ultrasonography for predicting central compartment lymph node metastases (CCLNM) of PTMC. One hundred twenty seven patients who underwent surgery for PTMC were enrolled in this study. The relationship between the CCLNM and the characteristics on conventional US, elastographic, and contrast enhanced ultrasound (CEUS) were investigated. Univariate analysis indicated that PTMCs with CCLNM were more often nodule irregular shape, microcalcifications, hyperenhancing or isoenhancing parametric maps, and peak index ≥1 at preoperative US and CEUS than those without CCLNM (P< 0.01, 0.05, 0.01 and 0.05 respectively). Multivariate analysis showed that microcalcification (OR:2.378, 95% CI: 1.096-5.158) and hyperenhancement or isoenhancement (OR:2.8, 95% CI: 1.287-6.094) were predictive for the presence of CCLNM. Elastography score was not significantly different between the groups. Our study indicated that preoperative thyroid nodule characteristics on conventional US and CEUS may serve as a useful tool to predict central compartment lymph node metastases in PTMC.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Hong
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Cao-Xin
authors.initials: CX
authors.lastname: Yan
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Guo-Qaing
authors.initials: GQ
authors.lastname: Mo
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Zhi-Yan
authors.initials: ZY
authors.lastname: Luo
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital Zhejiang University College of Medicine.
authors.forename: Pin-Tong
authors.initials: PT
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D003710:Demography; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018608:Ultrasonography, Doppler; D055815:Young Adult
chemical_list: D003287:Contrast Media