title: Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken.
abstract: Sporadic inclusion body myositis (sIBM) is the most frequently acquired myopathy in patients over 50 years of age. It is imperative that neurologists and rheumatologists recognize this disorder which may, through clinical and pathological similarities, mimic other myopathies, especially polymyositis. Whereas polymyositis responds to immunosuppressant drug therapy, sIBM responds poorly, if at all. Controversy reigns as to whether sIBM is primarily an inflammatory or a degenerative myopathy, the distinction being vitally important in terms of directing research for effective specific therapies. We review here the pros and the cons for the respective hypotheses. A possible scenario, which our experience leads us to favour, is that sIBM may start with inflammation within muscle. The rush of leukocytes attracted by chemokines and cytokines may induce fibre injury and HLA-I overexpression. If the protein degradation systems are overloaded (possibly due to genetic predisposition, particular HLA-I subtypes or ageing), amyloid and other protein deposits may appear within muscle fibres, reinforcing the myopathic process in a vicious circle.
authors.affiliation: Département de Médecine Interne et Immunologie Clinique, Assistance Publique-Hôpitaux de Paris, GH Pitié-Salpêtrière, Université Pierre et Marie Curie, Inserm, U974, DHU I2B, Paris, France, olivier.benveniste@psl.aphp.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Benveniste
authors.forename: Werner
authors.initials: W
authors.lastname: Stenzel
authors.forename: David
authors.initials: D
authors.lastname: Hilton-Jones
authors.forename: Marco
authors.initials: M
authors.lastname: Sandri
authors.forename: Olivier
authors.initials: O
authors.lastname: Boyer
authors.forename: Baziel G M
authors.initials: BG
authors.lastname: van Engelen
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D018925:Chemokines / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008875:Middle Aged; D009132:Muscles / Q000276:immunology* / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000276:immunology* / Q000473:pathology*; D058225:Plaque, Amyloid / Q000473:pathology*
chemical_list: D018925:Chemokines; D016207:Cytokines; D006680:HLA Antigens