title: Direct generation of oxygen-stabilized radicals by H• transfer from transition metal hydrides.
abstract: Transition-metal hydrides generate α-alkoxy radicals by H• transfer to enol ethers. We have measured the rate constant for transfer from CpCr(CO)3H to n-butyl vinyl ether and have examined the chemistry of radicals generated by such transfers. Radicals from appropriate substrates undergo 5-exo cyclization, with higher diastereoselectivity than the analogous all-carbon radicals. From such radicals it is straightforward to make substituted tetrahydrofurans.
authors.affiliation: Department of Chemistry, Columbia University , 3000 Broadway, New York, New York 10027, United States.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Kuo
authors.forename: John
authors.initials: J
authors.lastname: Hartung
authors.forename: Arthur
authors.initials: A
authors.lastname: Han
authors.forename: Jack R
authors.initials: JR
authors.lastname: Norton