title: Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections.
abstract: In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
authors.affiliation: Department of Chemistry, Department of Chemical Engineering, and Department of Materials Science & Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, USA. wooley@chem.tamu.edu.
authors.forename: Fuwu
authors.initials: F
authors.lastname: Zhang
authors.forename: Justin A
authors.initials: JA
authors.lastname: Smolen
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Richen
authors.initials: R
authors.lastname: Li
authors.forename: Parth N
authors.initials: PN
authors.lastname: Shah
authors.forename: Sangho
authors.initials: S
authors.lastname: Cho
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Jeffery E
authors.initials: JE
authors.lastname: Raymond
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Cannon
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley
mesh_terms: D000085:Acetates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001424:Bacterial Infections / Q000188:drug therapy*; D001672:Biocompatible Materials / Q000737:chemistry*; D001980:Bronchi / Q000166:cytology; D002412:Cations; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000382:microbiology; D016503:Drug Delivery Systems; D015195:Drug Design; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000382:microbiology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry; D012995:Solubility; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002412:Cations; D008823:Micelles; D011108:Polymers; D018030:Silver Compounds; D014867:Water; C103100:silver acetate; D012834:Silver