title: New onset refractory status epilepticus as an unusual presentation of a suspected organophosphate poisoning.
abstract: New onset refractory status epilepticus (NORSE) is a new entity in medical literature. It has different infectious and noninfectious etiologies showing a devastating impact onto the clinical outcome of patients. Therapy with anaesthetic and antiepileptic agents often fails to improve the condition, unless the primary cause is rectified. Here is presented the case of a young female with a history of depression who after a recent bereavement came to the Emergency Department of Aga Khan University Hospital with complaints of drowsiness that lasted for few hours. Though she had no history of organophosphate poisoning, her physical examination and further investigations were suggestive of the diagnosis. During her hospital stay, she developed refractory status epilepticus. Her seizures did not respond to standard antiepileptic and intravenous anesthetic agents and subsided only after intravenous infusion of atropine for a few days. Organophosphate poisoning is a very common presentation in the developing world and the associated status epilepticus poses a devastating problem for emergency physicians. In patients with suspected organophosphate poisoning with favoring clinical exam findings, the continuation of atropine intravenous infusion can be a safe option to abate seizures.
authors.affiliation: Department of Emergency Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan.
authors.forename: Shahan
authors.initials: S
authors.lastname: Waheed
authors.affiliation: Department of Internal Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan.
authors.forename: Amber
authors.initials: A
authors.lastname: Sabeen
authors.affiliation: Department of Emergency Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ullah Khan