title: Manifestations and clinical impact of pediatric inherited thrombophilia.
abstract: The etiology of pediatric venous thromboembolic disease (VTE) is multifactorial, and in most children, 1 or more clinical risk factors are present. In addition, inherited thrombophilic disorders contribute to the development of pediatric VTE. In this review, the role of inherited thrombophilic disorders in the development of pediatric VTE, as well as the benefits and limitations of thrombophilia testing, will be discussed.
authors.affiliation: Department of Pediatric Hematology, Emma Children's Hospital Academic Medical Center, and Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Irene L M
authors.initials: IL
authors.lastname: Klaassen
authors.affiliation: Department of Pediatric Hematology, Emma Children's Hospital Academic Medical Center, and.
authors.forename: C Heleen
authors.initials: CH
authors.lastname: van Ommen
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Saskia
authors.initials: S
authors.lastname: Middeldorp
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D006403:Hematologic Tests; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis* / Q000453:epidemiology*; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology