title: Metabolomics for laboratory diagnostics.
abstract: Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and in bioinformatics, metabolomics has been extensively applied as a novel, holistic diagnostic tool in clinical and biomedical studies. Metabolome's measurement, as a chemical reflection of a current phenotype of a particular biological system, is nowadays frequently implemented to understand pathophysiological processes involved in disease progression as well as to search for new diagnostic or prognostic biomarkers of various organism's disorders. In this review, we discussed the research strategies and analytical platforms commonly applied in the metabolomics studies. The applications of the metabolomics in laboratory diagnostics in the last 5 years were also reviewed according to the type of biological sample used in the metabolome's analysis. We also discussed some limitations and further improvements which should be considered taking in mind potential applications of metabolomic research and practice.
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, ul. Gen J. Hallera 107, Gdańsk 80-416, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Bujak
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, ul. Gen J. Hallera 107, Gdańsk 80-416, Poland.
authors.forename: Wiktoria
authors.initials: W
authors.lastname: Struck-Lewicka
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, ul. Gen J. Hallera 107, Gdańsk 80-416, Poland. Electronic address: markusz@gumed.edu.pl.
authors.forename: Michał J
authors.initials: MJ
authors.lastname: Markuszewski
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, ul. Gen J. Hallera 107, Gdańsk 80-416, Poland. Electronic address: roman.kaliszan@gumed.edu.pl.
authors.forename: Roman
authors.initials: R
authors.lastname: Kaliszan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D019411:Clinical Laboratory Techniques / Q000379:methods* / Q000639:trends; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D006801:Humans; D055442:Metabolome / Q000502:physiology; D055432:Metabolomics / Q000379:methods* / Q000639:trends
chemical_list: D015415:Biomarkers
keywords: Analytical techniques; Biological samples; Biomarkers; Laboratory diagnostics; Metabolomics