title: Metachronous cardiac and cerebral sarcomas: case report with focus on molecular findings and review of the literature.
abstract: Although multiple primary malignancies are relatively rare, they have increased in frequency over the last decades, partly because of advances in diagnosis and therapy. This report describes for the first time the case of a patient with past occupational exposure to asbestos and no family history of cancer who developed 2 rare primary malignancies: a cardiac sarcoma and a gliosarcoma 11 months later. Molecular-cytogenetic studies did not identify common lesions to these 2 rare metachronous sarcomas. The gliosarcoma was associated with monosomy 10 and underlying PTEN monoallelic loss, which has been recurrently observed. In the cardiac sarcoma, MDM2 amplification and CDKN2AB/9p21 biallelic deletion suggested intimal sarcoma. No causal relationship was found between cardiac sarcoma and asbestos exposure, although MDM2 abnormalities were linked to malignant mesothelioma.
authors.affiliation: Department of Experimental Medicine, Pathological Anatomy and Histology Unit, Medical School, University of Perugia, I-06129 Perugia, Italy. Electronic address: guerrieroangela@alice.it.
authors.forename: Angela
authors.initials: A
authors.lastname: Guerriero
authors.affiliation: Diagnostic Cytology and Histology Unit, S. Maria della Misericordia Hospital, I-06129 Perugia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Giovenali
authors.affiliation: Department of Medicine, Hematology and Bone Marrow Transplantation Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: La Starza
authors.affiliation: Department of Medicine, Hematology and Bone Marrow Transplantation Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mecucci
authors.affiliation: Department of Surgical and Biomedical Sciences, Radiotherapy Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Montesi
authors.affiliation: Cardiac Surgery Unit, S. Maria della Misericordia Hospital, I-06129 Perugia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pasquino
authors.affiliation: Department of Medicine, Hematology and Bone Marrow Transplantation Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pierini
authors.affiliation: Cardiac Surgery Unit, S. Maria della Misericordia Hospital, I-06129 Perugia, Italy.
authors.forename: Temistocle
authors.initials: T
authors.lastname: Ragni
authors.affiliation: Department of Experimental Medicine, Pathological Anatomy and Histology Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Sidoni
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D015815:Cell Adhesion Molecules / Q000032:analysis; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D018316:Gliosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006338:Heart Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D012509:Sarcoma / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D014746:Vimentin
keywords: Asbestos exposure; Cardiac sarcoma; Gliosarcoma; Multiple primary tumors; Synovial sarcoma