title: Influence of intracerebral hemorrhage location on incidence, characteristics, and outcome: population-based study.
abstract: OBJECTIVE
  The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because of differences in the distribution of underlying cerebral small vessel diseases. Therefore, we investigated the incidence, characteristics, and outcome of lobar and nonlobar ICH.
  
  
  METHODS
  In a population-based, prospective inception cohort study of ICH, we used multiple overlapping sources of case ascertainment and follow-up to identify and validate ICH diagnoses in 2010 to 2011 in an adult population of 695 335.
  
  
  RESULTS
  There were 128 participants with first-ever primary ICH. The overall incidence of lobar ICH was similar to nonlobar ICH (9.8 [95% confidence interval, 7.7-12.4] versus 8.6 [95% confidence interval, 6.7-11.1] per 100 000 adults/y). At baseline, adults with lobar ICH were more likely to have preceding dementia (21% versus 5%; P=0.01), lower Glasgow Coma Scale scores (median, 13 versus 14; P=0.03), larger ICHs (median, 38 versus 11 mL; P<0.001), subarachnoid extension (57% versus 5%; P<0.001), and subdural extension (15% versus 3%; P=0.02) than those with nonlobar ICH. One-year case fatality was lower after lobar ICH than after nonlobar ICH (adjusted odds ratio for death at 1 year: lobar versus nonlobar ICH 0.21; 95% confidence interval, 0.07-0.63; P=0.006, after adjustment for known predictors of outcome). There were 4 recurrent ICHs, which occurred exclusively in survivors of lobar ICH (annual risk of recurrent ICH after lobar ICH, 11.8%; 95% confidence interval, 4.6%-28.5% versus 0% after nonlobar ICH; log-rank P=0.04).
  
  
  CONCLUSIONS
  The baseline characteristics and outcome of lobar ICH differ from other locations.
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Neshika
authors.initials: N
authors.lastname: Samarasekera
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Arthur
authors.initials: A
authors.lastname: Fonville
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Christine
authors.initials: C
authors.lastname: Lerpiniere
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Farrall
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Wardlaw
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Philip M
authors.initials: PM
authors.lastname: White
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.).
authors.forename: Colin
authors.initials: C
authors.lastname: Smith
authors.affiliation: From the Division of Clinical Neurosciences, Centre for Clinical Brain Sciences (N.S., A.F., C.L., A.J.F., J.M.W., C.S., R.A.-S.S.), Brain Research Imaging Centre (A.J.F., J.M.W.), and Centre for Cognitive Ageing and Cognitive Epidemiology (J.M.W.), University of Edinburgh, Edinburgh, United Kingdom; and Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom (P.M.W.). Rustam.Al-Shahi@ed.ac.uk.
authors.forename: Rustam
authors.initials: R
authors.lastname: Al-Shahi Salman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: incidence; intracerebral hemorrhage; outcome; prognosis