title: Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension.
abstract: Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. Electronic address: ana.garcia@cnic.es.
authors.forename: Ana
authors.initials: A
authors.lastname: García-Álvarez
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Quirón Madrid, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: García-Lunar
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pereda
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Fernández-Jimenez
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Philips Healthcare Iberia, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-González
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Puerta de Hierro, Madrid, Spain.
authors.forename: Jesús G
authors.initials: JG
authors.lastname: Mirelis
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Nuño-Ayala
authors.affiliation: Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain.
authors.forename: Damian
authors.initials: D
authors.lastname: Sánchez-Quintana
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Montepríncipe, Madrid, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Fernández-Friera
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: García-Ruiz
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Quirón Madrid, Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Pizarro
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Agüero
authors.affiliation: Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Campelos
authors.affiliation: Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Castellá
authors.affiliation: Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Sabaté
authors.affiliation: Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuster
authors.affiliation: Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz
authors.affiliation: Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínico San Carlos, Madrid, Spain. Electronic address: bibanez@cnic.es.
authors.forename: Borja
authors.initials: B
authors.lastname: Ibañez
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D002908:Chronic Disease; D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics; D006976:Hypertension, Pulmonary / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology; D013552:Swine
keywords: T1 mapping; equilibrium contrast; extracellular volume; magnetic resonance; native T1; pulmonary hypertension