title: [Effects of ecological characteristics of place of residence on the incidence, prevalence and risk of multiple sclerosis in the Republic North Ossetia - Alania].
abstract: Objective. To study the relationship between characteristics of place of residence and epidemiological indicators of multiple sclerosis (MS) in the Republic North Ossetia - Alania. Material and methods. We present the data on the effects of environmental characteristics of place of residence on the incidence, prevalence and risk of MS. Data of 110 MS patients and matched controls have been analyzed. Results. Ecological characteristics of place of residence of MS patients differ significantly from those of controls. The prevalence and incidence of MS increase in patients who have moved from presumably pollution free areas to the places with high population density and plant facilities. Conclusion. MS is thought to be a disease caused by the interaction of genetic susceptibility and environmental factors. Risk factors are intoxication with heavy metal and chemical compounds and living in environmentally disadvantaged areas.
authors.affiliation: Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki lechebnogo fakul'teta GOU VPO "Rossiĭskiĭ nauchno-issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava Rossii; Otdelenie nevrologii Gorodskoĭ klinicheskoĭ i bol'nitsy Vladikavkaza, Respublika Severnaia Osetiia - Alaniia, Vladikavkaz.
authors.forename: M A
authors.initials: MA
authors.lastname: Khodova
authors.affiliation: GBOU VPO "Tiumenskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii, Tiumenskiĭ tsentr rasseiannogo skleroza, MSCh "Neftianik", Tiumen'
authors.forename: S A
authors.initials: SA
authors.lastname: Sivertseva
authors.affiliation: Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki lechebnogo fakul'teta GOU VPO "Rossiĭskiĭ nauchno-issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava Rossii.
authors.forename: N F
authors.initials: NF
authors.lastname: Smirnova
authors.affiliation: Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki lechebnogo fakul'teta GOU VPO "Rossiĭskiĭ nauchno-issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava Rossii.
authors.forename: E I
authors.initials: EI
authors.lastname: Gusev
authors.affiliation: Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki lechebnogo fakul'teta GOU VPO "Rossiĭskiĭ nauchno-issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava Rossii.
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko