title: Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study.
abstract: Although migraine is a neurological disorder known since long, its physiopathology remains unclear. Recent studies suggest that migraine is associated with oxidative stress; however, they report divergent results. The aim of the present study was to evaluate total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and serum thiol level in migraine patients with or without aura. The study group consisted of 141 migraine patients. The control group included 70 healthy subjects. TAS, TOS, OSI were evaluated using a method developed by Erel. Serum thiol level was measured using the Hu method. No difference was found in TAS, TOS, OSI between the patients and controls. The level of thiol was significantly lower in patients than in controls. Negative correlations were detected between thiol level and Migraine Disability Assessment score in patients. Although TAS, TOS, and OSI were similar to those of the control group, serum thiol level, an important marker of antioxidant capacity, was significantly lower in migraines compared with controls, and caused more serious disability. Novel treatment approaches may be developed based on these data, and compounds containing thiol, such as alpha lipoic acid and N-acetyl cysteine, may be used in prophylaxis.
authors.affiliation: Department of Neurology, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. yeren.72@hotmail.com.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Eren
authors.affiliation: Department of Neurology, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Dirik
authors.affiliation: Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neşelioğlu
authors.affiliation: Department of Biochemistry, Yıldırım Beyazıt University Medical Faculty, Ankara, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000097:blood*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds
keywords: Antioxidant; Migraine; Oxidant; Oxidative stress; Thiol