title: Insulin-derived amyloidosis.
abstract: Amyloidosis is the term for diseases caused by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. Insulin-derived amyloidosis is a rare, yet significant complication of insulin therapy. Insulin-derived amyloidosis at injection site can cause poor glycemic control and increased insulin dose requirements because of the impairment in insulin absorption, which reverse on change of injection site and/or excision of the mass. This entity should be considered and assessed by histopathology and immunohistochemistry, in patients with firm/hard local site reactions, which do not regress after cessation of insulin injection at the affected site.
  
  
  METHODS
  PubMed was searched with terms "insulin amyloidosis". Full text of articles available in English was reviewed. Relevant cross references were also reviewed. Last search was made on October 15, 2014.
authors.affiliation: Department of Medicine, Government Medical College and Hospital, Chandigarh, India.
authors.forename: Yashdeep
authors.initials: Y
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Vardhman Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Singla
authors.affiliation: Department of Endocrinology, Saket City Hospital, New Delhi, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Singla
keywords: Diabetes; insulin; insulin injection; insulin resistance; localized amyloidosis