title: Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China.
abstract: OBJECTIVE
  To investigate clinicopathologic features and identify prognostic factors of placental site trophoblastic tumor (PSTT).
  
  
  METHODS
  In a retrospective study, data were analyzed from patients with stage I PSTT treated at a tertiary hospital in Shanghai, China, from January 2007 to May 2013. Univariate log-rank tests were used to examine the association between clinicopathologic characteristics and overall survival and disease-free survival (DFS).
  
  
  RESULTS
  In total, seven patients had stage I PSTT. Mean age was 31.6 years (range 22-42). Four patients had term delivery as the outcome of their antecedent pregnancy. Six had a β-human chorionic gonadotropin (β-hCG) serum concentration of less than 10 000 mIU/mL. Among five patients who underwent hysterectomy combined with chemotherapy, one had recurrent disease. One patient received fertility-preserving therapy and achieved complete remission. The mean 5-year overall survival and DFS were 100% and 86%, respectively. Maximum β-HCG concentration of at least 10 000 mIU/mL and a mitotic index of more than 5 mitotic counts per 10 high-power fields were associated with disease recurrence (both P=0.014).
  
  
  CONCLUSIONS
  Pretreatment β-hCG concentration and mitotic index might be predictors of recurrence among patients with PSTT. Fertility-preserving therapy might be practical in some patients.
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
authors.forename: Yunxi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Bao
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ning
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Hua
authors.affiliation: Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China. Electronic address: yix@fudan.edu.cn.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Yi
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002681:China; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007044:Hysterectomy; D008940:Mitotic Index; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D018245:Trophoblastic Tumor, Placental Site / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D018997:Chorionic Gonadotropin, beta Subunit, Human
keywords: Fertility preservation; Placental site trophoblastic tumor; Prognosis; Recurrence