title: Selenium supplementation for autoimmune thyroiditis: a systematic review and meta-analysis.
abstract: Many studies have reported that selenium (Se) has a close relationship with autoimmune thyroiditis (AIT). The therapeutic effect of Se supplementation in AIT treatment remains unclear. The objective of the present study was to determine the efficacy of Se supplementation for the treatment of AIT. A structured literature search was undertaken to identify all randomized controlled trials conducted in patients with AIT receiving Se supplementation or placebo. Nine studies enrolling a total of 787 patients were included. The results showed that Se supplementation with duration 6 months significantly dropped the TPOAb titers but did not decrease the TgAb titers. Patients assigned to Se supplementation for 12-month duration showed significantly lower TPOAb titers and TgAb titers. Patients after Se supplementation had a higher chance to improve the mood or well-being compared with controls. Se supplementation is associated with a significant decrease in TPOAb titers at 6 and 12 months; meanwhile, the TgAb titers can be dropped at 12 months. After Se supplementation treatment, patients had a higher chance to improve the mood without significant adverse events.
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Yaofu
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Shuhang
authors.initials: S
authors.lastname: Xu
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Cao
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Guofang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Di
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Cao
authors.affiliation: Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China.
authors.forename: Chao
authors.identifier: 0000-0002-8705-6407
authors.initials: C
authors.lastname: Liu