title: Preparation and antibacterial activity of quaternized chitosan with iodine.
abstract: Chitosan (CTS) is a natural polymer with active groups such as -NH2 which can be functionalized to introduce new positively charged N-atoms and protonated amino group for better use. In this study, to improve the stability of iodine, a novel complex (CTS-CTA-I2) was prepared by mixing N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (CTS-CTA) with iodine in ethanol solution. The CTS-CTA-I2 was characterized by Fourier transform infrared spectra (FTIR), Ultraviolet and visible (UV-vis) spectra and thermal gravimetric analysis (TG). Besides, the interaction of iodine with CTS-CTA was also studied. The mole ratio of CTS-CTA with iodine was measured by iodometric titration method and the max mole ratio of CTS-CTA with iodine was 1:1.33. The antimicrobial activity of CTS, CTS-CTA and CTS-CTS-I2 complexes was investigated against Escherichia coli and Staphylococcus aureus and the antibacterial property of CTS-CTA-I2 was superior to CTS-CTA.
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Longteng Road 333, Shanghai 201620, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Longteng Road 333, Shanghai 201620, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Xie
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Longteng Road 333, Shanghai 201620, China.
authors.forename: Mingze
authors.initials: M
authors.lastname: Sai
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Longteng Road 333, Shanghai 201620, China.
authors.forename: Ningning
authors.initials: N
authors.lastname: Xu
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Longteng Road 333, Shanghai 201620, China. Electronic address: dingderun@sues.edu.cn.
authors.forename: Derun
authors.initials: D
authors.lastname: Ding
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry*; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects; D007455:Iodine / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; C550160:N-(2-hydroxypropyl)-3-trimethylammonium chitosan; D000644:Quaternary Ammonium Compounds; C495830:chitosan-N-2-hydroxypropyl trimethyl ammonium chloride; D048271:Chitosan; D007455:Iodine
keywords: Antibacterial; Chitosan; Iodine; Iodometric titration; Quaternization