title: Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives.
abstract: Biodemography became one of the most innovative and fastest growing areas in demography. This progress is fueled by the growing variability and amount of relevant data available for analyses as well as by methodological developments allowing for addressing new research questions using new approaches that can better utilize the potential of these data. In this review paper, we summarize recent methodological advances in biodemography and their diverse practical applications. Three major topics are covered: (1) computational approaches to reconstruction of age patterns of incidence of geriatric diseases and other characteristics such as recovery rates at the population level using Medicare claims data; (2) methodological advances in genetic and genomic biodemography and applications to research on genetic determinants of longevity and health; and (3) biodemographic models for joint analyses of time-to-event data and longitudinal measurements of biomarkers collected in longitudinal studies on aging. We discuss how such data and methodology can be used in a comprehensive prediction model for joint analyses of incomplete datasets that take into account the wide spectrum of factors affecting health and mortality transitions including genetic factors and hidden mechanisms of aging-related changes in physiological variables in their dynamic connection with health and survival.
authors.affiliation: Center for Population Health and Aging, Duke University, Erwin Mill Building, 2024 W. Main Street, P.O. Box 90420, Durham, NC 27705, USA.
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Arbeev
authors.affiliation: Center for Population Health and Aging, Duke University, Erwin Mill Building, 2024 W. Main Street, P.O. Box 90420, Durham, NC 27705, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Akushevich
authors.affiliation: Center for Population Health and Aging, Duke University, Erwin Mill Building, 2024 W. Main Street, P.O. Box 90420, Durham, NC 27705, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Kulminski
authors.affiliation: Center for Population Health and Aging, Duke University, Erwin Mill Building, 2024 W. Main Street, P.O. Box 90420, Durham, NC 27705, USA.
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Ukraintseva
authors.affiliation: Center for Population Health and Aging, Duke University, Erwin Mill Building, 2024 W. Main Street, P.O. Box 90420, Durham, NC 27705, USA.
authors.forename: Anatoliy I
authors.initials: AI
authors.lastname: Yashin