title: Serum Uric Acid, Gender, and Low Ankle Brachial Index in Adults With High Cardiovascular Risk.
abstract: Uric acid (UA) has been reported to be associated with cardiovascular disease (CVD) in caucasians. However, it is unclear whether this association remains significant in a Chinese population. The present study aimed to investigate the association between UA and low ankle brachial index (ABI), a measurement of peripheral arterial disease, in Chinese patients. A total of 6262 hospital-based patients with high CVD risk were enrolled. Low ABI was defined as ABI ≤0.9 in either side. Low ABI was detected in 1390 (22.2%) patients. Higher UA was significantly associated with higher risk of low ABI and modified by gender (P = .0045). After adjusting for age, body mass index, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, hypertension, and smoking, participants in the highest quartile of UA exhibited 37% (odds ratio [OR]:1.37, 95% confidence interval [CI]: 1.03-1.82) higher risk of low ABI compared to those in the lowest quartile in men, while OR (95% CI) was 1.69 (1.29-2.22) for women. However, when kidney function was further adjusted, the associations were attenuated in both men and women and were significant only in women. The results were suggestive of higher UA associating with higher risk of low ABI in women, and the association was largely driven by kidney function, especially in men.
authors.affiliation: Institute of Clinical Epidemiology, School of Public Health, Fudan University, Shanghai, P. R. China.
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Preventive Medicine, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Institute of Clinical Epidemiology, School of Public Health, Fudan University, Shanghai, P. R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Chronic Disease Prevention, Minhang Center for Disease Control and Prevention, Shanghai, P. R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Heart Center, Peking University People's Hospital, Beijing, P. R. China.
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
authors.affiliation: Institute of Clinical Epidemiology, School of Public Health, Fudan University, Shanghai, P. R. China Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, P. R. China jmy@fudan.edu.cn.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000208:ethnology; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000208:ethnology; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: ankle brachial index; gender differences; peripheral arterial disease; uric acid