title: Links between mechanical behavior of cancellous bone and its microstructural properties under dynamic loading.
abstract: Previous studies show that in vivo assessment of fracture risk can be achieved by identifying the relationships between microarchitecture description from clinical imaging and mechanical properties. This study demonstrates that results obtained at low strain rates can be extrapolated to loadings with an order of magnitude similar to trauma such as car crashes. Cancellous bovine bone specimens were compressed under dynamic loadings (with and without confinement) and the mechanical response properties were identified, such as Young׳s modulus, ultimate stress, ultimate strain, and ultimate strain energy. Specimens were previously scanned with pQCT, and architectural and structural microstructure properties were identified, such as parameters of geometry, topology, connectivity and anisotropy. The usefulness of micro-architecture description studied was in agreement with statistics laws. Finally, the differences between dynamic confined and non-confined tests were assessed by the bone marrow influence and the cancellous bone response to different boundary conditions. Results indicate that architectural parameters, such as the bone volume fraction (BV/TV), are as strong determinants of mechanical response parameters as ultimate stress at high strain rates (p-value<0.001). This study reveals that cancellous bone response at high strain rates, under different boundary conditions, can be predicted from the architectural parameters, and that these relations with mechanical properties can be used to make fracture risk prediction at a determined magnitude.
authors.affiliation: LBM/Institut de Biomécanique Humaine Georges Charpak, 151 Boulevard de l׳Hôpital, 75013 Paris, France. Electronic address: marianne.prot@ensam.eu.
authors.forename: M
authors.initials: M
authors.lastname: Prot
authors.affiliation: LBM/Institut de Biomécanique Humaine Georges Charpak, 151 Boulevard de l׳Hôpital, 75013 Paris, France; Univ. Grenoble Alpes, 3SR, F-38000 Grenoble, France.
authors.forename: D
authors.initials: D
authors.lastname: Saletti
authors.affiliation: LMT-Cachan (ENS Cachan/CNRS/Université Paris VI/Pres UniversSud Paris), 61 Avenue du Président Wilson, 94230 Cachan, France.
authors.forename: S
authors.initials: S
authors.lastname: Pattofatto
authors.affiliation: Service de Radiologie Ostéo-Articulaire, Hôpital Lariboisière, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Bousson
authors.affiliation: LBM/Institut de Biomécanique Humaine Georges Charpak, 151 Boulevard de l׳Hôpital, 75013 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Laporte
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002417:Cattle; D004548:Elasticity; D005269:Femur / Q000166:cytology*; D066298:In Vitro Techniques; D023421:Models, Animal; D013314:Stress, Mechanical; D016474:Weight-Bearing
keywords: Cancellous bone; Confinement; Dynamic behavior; Microstructural parameters