title: A new test of computational protein design: predicting posttranslational modification specificity for the enzyme SMYD2.
abstract: In this issue of Structure, Lanouette and colleagues use a combination of computation and experiment to define a specificity motif for the lysine methyltransferase SMYD2. Using this motif, they predict and experimentally verify four new SMYD2 substrates.
authors.affiliation: Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, ND11.136, Dallas, TX 75390-8597, USA. Electronic address: kimberly.reynolds@utsouthwestern.edu.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Reynolds
mesh_terms: D019295:Computational Biology / Q000379:methods*; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D060066:Protein Interaction Maps
chemical_list: D011495:Histone-Lysine N-Methyltransferase