title: Rh-Catalyzed decarbonylative coupling with alkynes via C-C activation of isatins.
abstract: Herein we report a [5 + 2 - 1] transformation though catalytic decarbonylative coupling between isatins and alkynes, which provides a unique way to synthesize 2-quinolinone derivatives. A broad range of alkynes can be coupled efficiently with high regioselectivity. This reaction is proposed to go through C-C activation of isatins, followed by decarbonylation and alkyne insertion. Directing group (DG) plays a critical role in this transformation. Assisted by the DG, the C-C cleavage of isatins occurs at room temperature.
authors.affiliation: Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
authors.forename: Rong
authors.initials: R
authors.lastname: Zeng
authors.forename: Guangbin
authors.initials: G
authors.lastname: Dong
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007510:Isatin / Q000737:chemistry*; D008958:Models, Molecular; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D015363:Quinolones; D007510:Isatin; D012238:Rhodium