title: Association of Concurrent fNIRS and EEG Signatures in Response to Auditory and Visual Stimuli.
abstract: Functional near-infrared spectroscopy (fNIRS) has been proven reliable for investigation of low-level visual processing in both infants and adults. Similar investigation of fundamental auditory processes with fNIRS, however, remains only partially complete. Here we employed a systematic three-level validation approach to investigate whether fNIRS could capture fundamental aspects of bottom-up acoustic processing. We performed a simultaneous fNIRS-EEG experiment with visual and auditory stimulation in 24 participants, which allowed the relationship between changes in neural activity and hemoglobin concentrations to be studied. In the first level, the fNIRS results showed a clear distinction between visual and auditory sensory modalities. Specifically, the results demonstrated area specificity, that is, maximal fNIRS responses in visual and auditory areas for the visual and auditory stimuli respectively, and stimulus selectivity, whereby the visual and auditory areas responded mainly toward their respective stimuli. In the second level, a stimulus-dependent modulation of the fNIRS signal was observed in the visual area, as well as a loudness modulation in the auditory area. Finally in the last level, we observed significant correlations between simultaneously-recorded visual evoked potentials and deoxygenated hemoglobin (DeoxyHb) concentration, and between late auditory evoked potentials and oxygenated hemoglobin (OxyHb) concentration. In sum, these results suggest good sensitivity of fNIRS to low-level sensory processing in both the visual and the auditory domain, and provide further evidence of the neurovascular coupling between hemoglobin concentration changes and non-invasive brain electrical activity.
authors.affiliation: Neuropsychology Lab, Department of Psychology, European Medical School, Carl-von-Ossietzky University Oldenburg, 26111, Oldenburg, Germany. ling-chia.chen@uni-oldenburg.de.
authors.forename: Ling-Chia
authors.initials: LC
authors.lastname: Chen
authors.affiliation: Neuropsychology Lab, Department of Psychology, European Medical School, Carl-von-Ossietzky University Oldenburg, 26111, Oldenburg, Germany.|Department of Neurology, Hannover Medical School, Hannover, Germany.|Cluster of Excellence Hearing4all, Oldenburg, Germany.
authors.forename: Pascale
authors.initials: P
authors.lastname: Sandmann
authors.affiliation: Neuropsychology Lab, Department of Psychology, European Medical School, Carl-von-Ossietzky University Oldenburg, 26111, Oldenburg, Germany.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Thorne
authors.affiliation: Cluster of Excellence Hearing4all, Oldenburg, Germany.|Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany.|Experimental Psychology Lab, Department of Psychology, European Medical School, Carl-von-Ossietzky University Oldenburg, Oldenburg, Germany.
authors.forename: Christoph S
authors.initials: CS
authors.lastname: Herrmann
authors.affiliation: Neuropsychology Lab, Department of Psychology, European Medical School, Carl-von-Ossietzky University Oldenburg, 26111, Oldenburg, Germany.|Cluster of Excellence Hearing4all, Oldenburg, Germany.|Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Debener
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography / Q000379:methods*; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D000069336:Neurovascular Coupling / Q000502:physiology; D010775:Photic Stimulation; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014793:Visual Cortex / Q000502:physiology