title: Usefulness of CA125 in the differential diagnosis of uterine adenomyosis and myoma.
abstract: OBJECTIVE
  To evaluate the usefulness of CA125 levels in the differential diagnosis of adenomyosis and myoma. This has been addressed by few, if any, previous studies.
  
  
  METHODS
  Preoperative serum CA125 levels were measured in 2149 women who were diagnosed at total hysterectomy as having adenomyosis, myoma, endometriosis, and/or normal pelvis. Their medical records were retrieved and reviewed.
  
  
  RESULTS
  The mean serum CA125 level in the adenomyosis patients was significantly greater than that in the patients diagnosed with myoma (65.21±96.60 U/mL vs.12.86±14.23 U/mL, respectively; P<0.001). In the differential diagnosis of adenomyosis and myoma, the cut-off serum CA125 level with the highest accuracy (78.8%) and highest diagnostic value (61.2%) was 19 U/mL. Using this cut-off value, the negative predictive value was 69.5%, and the positive predictive value was 76.5%. These results are clearly superior to those of the empirical single cut-off value of 35 U/mL. Receiver operating characteristic curve analysis revealed the area under the curve for differentiating adenomyosis from myoma was 0.776, indicating good diagnostic performance.
  
  
  CONCLUSIONS
  In the differential diagnosis of adenomyosis and myoma, cut-off values for CA125, particularly the cut-off value of 19 U/mL, provide improved diagnostic performance. Serum CA125 testing can be performed during the initial screening of women with possible adenomyosis to differentiate this condition from myoma, although the diagnostic accuracy of using CA125 testing alone is limited.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Kicheol
authors.initials: K
authors.lastname: Kil
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Jae-Eun
authors.initials: JE
authors.lastname: Chung
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Pak
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: In-Cheul
authors.initials: IC
authors.lastname: Jeung
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Jang Heub
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Jo
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Sucho-gu, Seoul 137-701, Republic of Korea. Electronic address: mrkim@catholic.ac.kr.
authors.forename: Mee-Ran
authors.initials: MR
authors.lastname: Kim
mesh_terms: D062788:Adenomyosis / Q000097:blood* / Q000175:diagnosis; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood* / Q000175:diagnosis; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins
keywords: Adenomyosis; CA125; Myoma