title: Gelatin-based particulate systems in ocular drug delivery.
abstract: Despite all scientists efforts exerted over the past years, the ocular delivery of drugs remains a great challenge due to several barriers and hurdles faced by this kind of administration. The exploitation of gelatin that has a long history of safe use in pharmaceuticals and which is considered as a GRAS (Generally Regarded As Safe) material by the FDA was not fully achieved in this field. This review summarizes the recent studies and findings where gelatin-based micro- and nanoparticles were used for successful ocular delivery aiming at drawing the attention of researchers and scientists to this valuable biomaterial that has not been fully explored.
authors.affiliation: a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.
authors.forename: Rania M
authors.initials: RM
authors.lastname: Hathout
authors.affiliation: a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.
authors.forename: Mohamed K
authors.initials: MK
authors.lastname: Omran
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005123:Eye / Q000187:drug effects*; D005780:Gelatin / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D005780:Gelatin
keywords: Biomaterial; drug delivery; gelatin; ocular; particles