title: The anisotropic network model web server at 2015 (ANM 2.0).
abstract: CONCLUSIONS
  The anisotropic network model (ANM) is one of the simplest yet powerful tools for exploring protein dynamics. Its main utility is to predict and visualize the collective motions of large complexes and assemblies near their equilibrium structures. The ANM server, introduced by us in 2006 helped making this tool more accessible to non-sophisticated users. We now provide a new version (ANM 2.0), which allows inclusion of nucleic acids and ligands in the network model and thus enables the investigation of the collective motions of protein-DNA/RNA and -ligand systems. The new version offers the flexibility of defining the system nodes and the interaction types and cutoffs. It also includes extensive improvements in hardware, software and graphical interfaces.
  
  
  METHODS
  ANM 2.0 is available at http://anm.csb.pitt.edu
  
  
  BACKGROUND
  eran.eyal@sheba.health.gov.il, eyal.eran@gmail.com.
authors.affiliation: Cancer Research Institute, Sheba Medical Center, 2 Sheba Rd, Ramat Gan 52621, Israel and Department of Computational and System Biology, University of Pittsburgh, 3501 Fifth Ave, Pittsburgh, PA 15213, USA.
authors.forename: Eran
authors.initials: E
authors.lastname: Eyal
authors.affiliation: Cancer Research Institute, Sheba Medical Center, 2 Sheba Rd, Ramat Gan 52621, Israel and Department of Computational and System Biology, University of Pittsburgh, 3501 Fifth Ave, Pittsburgh, PA 15213, USA.
authors.forename: Gengkon
authors.initials: G
authors.lastname: Lum
authors.affiliation: Cancer Research Institute, Sheba Medical Center, 2 Sheba Rd, Ramat Gan 52621, Israel and Department of Computational and System Biology, University of Pittsburgh, 3501 Fifth Ave, Pittsburgh, PA 15213, USA.
authors.forename: Ivet
authors.initials: I
authors.lastname: Bahar
mesh_terms: D016880:Anisotropy; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D020407:Internet; D008024:Ligands; D009038:Motion; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D012984:Software
chemical_list: D004268:DNA-Binding Proteins; D008024:Ligands; D011506:Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA