title: The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor.
abstract: Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Kirboga
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Ayse V
authors.initials: AV
authors.lastname: Ozec
authors.affiliation: Department of Ophthalmology, Ulus State Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kosker
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dursun
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Mustafa I
authors.initials: MI
authors.lastname: Toker
authors.affiliation: Department of Biochemistry, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aydin
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Erdogan
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Aysen
authors.initials: A
authors.lastname: Topalkara
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey.
authors.forename: Mustafa K
authors.initials: MK
authors.lastname: Arici