title: Demographics of natural oral infection of mosquitos by Venezuelan equine encephalitis virus.
abstract: The within-host diversity of virus populations can be drastically limited during between-host transmission, with primary infection of hosts representing a major constraint to diversity maintenance. However, there is an extreme paucity of quantitative data on the demographic changes experienced by virus populations during primary infection. Here, the multiplicity of cellular infection (MOI) and population bottlenecks were quantified during primary mosquito infection by Venezuelan equine encephalitis virus, an arbovirus causing neurological disease in humans and equids.
authors.affiliation: Cirad, UMR15 CMAEE, Montpellier, France INRA, UMR1309 CMAEE, Montpellier, France serafin.gutierrez@cirad.fr sweaver@utmb.edu.
authors.forename: Serafín
authors.initials: S
authors.lastname: Gutiérrez
authors.affiliation: INRA, UMR 385 BGPI, Montpellier, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Thébaud
authors.affiliation: Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: Darci R
authors.initials: DR
authors.lastname: Smith
authors.affiliation: Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: Joan L
authors.initials: JL
authors.lastname: Kenney
authors.affiliation: Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA serafin.gutierrez@cirad.fr sweaver@utmb.edu.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Weaver
mesh_terms: D000818:Animals; D009033:Culicidae / Q000821:virology*; D004666:Encephalitis Virus, Venezuelan Equine / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014644:Genetic Variation; D007303:Insect Vectors; D009055:Mouth / Q000821:virology