title: Using functional MRI alone for localization in focal epilepsy.
abstract: In the present study, we developed a method for the purpose of localizing epilepsy related hemodynamic foci for patients suffering intractable focal epilepsy using resting state fMRI alone. We studied two groups of subjects: five patients with intractable focal epilepsy, and ten healthy volunteers performing motor tasks. Spatial independent component analysis (ICA) was performed on the fMRI alone data and a set of independent component (IC) selection criteria was developed to identify epilepsy related ICs. The method was then evaluated in the healthy group with motor tasks. In all five surgery patients, there was at least one identified IC concordant with surgical resection. In the motor task study of healthy subjects, our method revealed components with concordant spatial and temporal features as expected from the unilateral motor tasks. These results suggest the lateralization and localization value of fMRI alone in presurgical evaluation for patients with intractable unilateral focal epilepsy. The proposed method is noninvasive in nature and easy to implement. It has the potential to be incorporated in current presurgical workup for the diagnosis of intractable focal epilepsy patients.
authors.forename: Clara H
authors.initials: CH
authors.lastname: Zhang
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lu
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brinkmann
authors.forename: Kirk
authors.initials: K
authors.lastname: Welker
authors.forename: Gregory
authors.initials: G
authors.lastname: Worrell
authors.forename: Bin
authors.initials: B
authors.lastname: He
mesh_terms: D000328:Adult; D004828:Epilepsies, Partial / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D013647:Task Performance and Analysis; D055815:Young Adult