title: Increase of the seizure threshold in C57BL/6 mice after citicoline administration.
abstract: We studied the dose-dependent effect of preventive intraperitoneal injection of citicoline (cytidine 5'-diphosphocholine) on acute generalized epileptiform activity in C57Bl/6 mice. The duration of citicoline action was also evaluated. Administration of citicoline in doses of 500 and 1000 mg/kg 1 h before treatment with the convulsant agent pentylenetetrazole produced an anticonvulsant effect. This effect was manifested in an increase of the threshold of clonic seizures and tonic phase of seizures with lethal outcome. Moreover, the latency of seizure development was elevated under these conditions. The anticonvulsant effect of citicoline persisted for 6 h after its injection.
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, karpova777@inbox.ru.
authors.forename: M N
authors.initials: MN
authors.lastname: Karpova
authors.forename: K A
authors.initials: KA
authors.lastname: Zin'kovskii
authors.forename: L V
authors.initials: LV
authors.lastname: Kuznetsova
authors.forename: N V
authors.initials: NV
authors.lastname: Klishina
mesh_terms: D000818:Animals; D003292:Convulsants / Q000627:therapeutic use*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*
chemical_list: D003292:Convulsants; D003566:Cytidine Diphosphate Choline; D010433:Pentylenetetrazole