title: Altered mTORC1 signaling in multipotent stem cells from nearly 25% of patients with nonsyndromic autism spectrum disorders.
authors.affiliation: Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.
authors.forename: A M
authors.initials: AM
authors.lastname: Suzuki
authors.affiliation: 1] Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil [2] Hospital lsraelita Albert Einstein, Centro de Pesquisa Experimental, São Paulo, Brasil.
authors.forename: K
authors.initials: K
authors.lastname: Griesi-Oliveira
authors.affiliation: Hospital lsraelita Albert Einstein, Centro de Pesquisa Experimental, São Paulo, Brasil.
authors.forename: C
authors.initials: C
authors.lastname: de Oliveira Freitas Machado
authors.affiliation: Instituto de Psiquiatria, Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
authors.forename: E
authors.initials: E
authors.lastname: Vadasz
authors.affiliation: Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.
authors.forename: E C
authors.initials: EC
authors.lastname: Zachi
authors.affiliation: Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.
authors.forename: M R
authors.initials: MR
authors.lastname: Passos-Bueno
authors.affiliation: Hospital lsraelita Albert Einstein, Centro de Pesquisa Experimental, São Paulo, Brasil.
authors.forename: A L
authors.initials: AL
authors.lastname: Sertie
mesh_terms: D000730:Androstadienes / Q000494:pharmacology; D000067877:Autism Spectrum Disorder / Q000473:pathology*; D016022:Case-Control Studies; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D000076222:Mechanistic Target of Rapamycin Complex 1; D039902:Multipotent Stem Cells / Q000187:drug effects / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D044967:Serum / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D013997:Time Factors; D000077191:Wortmannin
chemical_list: D000730:Androstadienes; D016895:Culture Media, Serum-Free; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus; D000077191:Wortmannin