title: Understanding host-adherent-invasive Escherichia coli interaction in Crohn's disease: opening up new therapeutic strategies.
abstract: A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.
authors.affiliation: Clermont Université, M2iSH, UMR 1071 INSERM/Université d'Auvergne, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France ; Unité Sous Contrat 2018, Institut National de la Recherche Agronomique, 63001 Clermont-Ferrand, France.
authors.forename: Allison
authors.identifier: 0000-0003-0007-9073
authors.initials: A
authors.lastname: Agus
authors.affiliation: Clermont Université, M2iSH, UMR 1071 INSERM/Université d'Auvergne, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France ; Unité Sous Contrat 2018, Institut National de la Recherche Agronomique, 63001 Clermont-Ferrand, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Massier
authors.affiliation: Clermont Université, M2iSH, UMR 1071 INSERM/Université d'Auvergne, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France ; Unité Sous Contrat 2018, Institut National de la Recherche Agronomique, 63001 Clermont-Ferrand, France ; Institut Universitaire de Technologie, Génie Biologique, 63172 Aubière, France.
authors.forename: Arlette
authors.initials: A
authors.lastname: Darfeuille-Michaud
authors.affiliation: Clermont Université, M2iSH, UMR 1071 INSERM/Université d'Auvergne, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France ; Unité Sous Contrat 2018, Institut National de la Recherche Agronomique, 63001 Clermont-Ferrand, France ; Institut Universitaire de Technologie, Génie Biologique, 63172 Aubière, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Billard
authors.affiliation: Clermont Université, M2iSH, UMR 1071 INSERM/Université d'Auvergne, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France ; Unité Sous Contrat 2018, Institut National de la Recherche Agronomique, 63001 Clermont-Ferrand, France ; Institut Universitaire de Technologie, Génie Biologique, 63172 Aubière, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barnich
mesh_terms: D001422:Bacterial Adhesion; D003424:Crohn Disease / Q000382:microbiology* / Q000628:therapy; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000628:therapy; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D064307:Microbiota