title: Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile.
abstract: C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection.
authors.affiliation: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: K Leigh
authors.initials: KL
authors.lastname: Greathouse
authors.affiliation: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Curtis C
authors.initials: CC
authors.lastname: Harris
authors.affiliation: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA. Electronic address: scott_bultman@med.unc.edu.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Bultman
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D016360:Clostridioides difficile / Q000502:physiology*; D004198:Disease Susceptibility / Q000382:microbiology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*; D064307:Microbiota / Q000502:physiology*
chemical_list: D001647:Bile Acids and Salts