title: Papillomacular bundle and inner retinal thicknesses correlate with visual acuity in nonarteritic anterior ischemic optic neuropathy.
abstract: OBJECTIVE
  To evaluate the ability of the papillomacular bundle (PMB) retinal nerve fiber layer and macular inner retinal layer thickness measurements with Spectralis optical coherence tomography (OCT) to differentiate eyes with nonarteritic anterior ischemic optic neuropathy (NAION) from uninvolved eyes and to evaluate whether their thicknesses correlate with visual acuity.
  
  
  METHODS
  An observational, cross-sectional study was performed, including 29 eyes with NAION and 29 uninvolved eyes from 29 patients. Eyes underwent scanning with Cirrus OCT (peripapillary and macular scanning) and Spectralis OCT (N-site axonal peripapillary scan and a new automated segmentation macular scan to measure individual retinal layers) in both eyes.
  
  
  RESULTS
  The NAION eyes showed significant thinning versus uninvolved eyes in the macular retinal nerve fiber (P < 0.05), ganglion cell layer (GCL; P < 0.001), and inner plexiform layer (IPL; P < 0.01) by Spectralis and in the GCL-IPL by Cirrus (P < 0.02). Average and sectors of peripapillary retinal nerve fiber layer (pRNFL) and total macular thickness (TMT) were significantly reduced in NAION eyes, with both Spectralis and Cirrus OCT (P < 0.05). Spectralis temporal (ρSpearman = -0.768; P < 0.001) and PMB pRNFL thicknesses (ρSpearman = -0.675; P < 0.001), as well as central macular IPL thickness (ρSpearman = -0.735; P < 0.001), correlated strongly with best corrected visual acuity (BCVA). Quadratic regression using outer nasal TMT by Cirrus OCT and temporal pRNFL thickness by Spectralis were the best models to predict BCVA.
  
  
  CONCLUSIONS
  Macular segmentation by Spectralis and Cirrus OCT revealed inner retinal layer atrophy in NAION eyes. The temporal and PMB pRNFL thicknesses and central macular IPL thickness by Spectralis-OCT and outer nasal TMT by Cirrus were strongly correlated with BCVA in NAION eyes.
authors.affiliation: Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain Department of Surgery, Universidad de Alcalá School of Medicine, Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Rebolleda
authors.affiliation: Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain Department of Surgery, Universidad de Alcalá School of Medicine, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez-Sánchez
authors.affiliation: Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: González-López
authors.affiliation: Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: Contreras
authors.affiliation: Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain Department of Surgery, Universidad de Alcalá School of Medicine, Madrid, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Muñoz-Negrete
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: ischemic optic neuropathy; optic disc; optic nerve; optical coherence tomography; retina