title: Interaction between EEG and drug concentration to predict response to noxious stimulation during sedation-analgesia: effect of the A118G genetic polymorphism.
abstract: The level of sedation in patients undergoing medical procedures is affected by the interaction between the effect of the anesthetic and analgesic agents and the pain stimuli. The presence of the A118G single nucleotide polymorphism (SNP) in the OPRM1 gene affects the requirements of opioids for patients undergoing sedation-analgesia. The purpose of this work is to evaluate the influence of the SNP A118G in OPRM1 on EEG measures for the prediction of the response to pain stimulation during endoscopy procedure. The proposed measures were based on power spectral density and auto-mutual information function. It was found that the statistical performances of the EEG measures improved when the presence of the SNP was taken into account (prediction probability Pk>0.9).
authors.forename: Umberto
authors.initials: U
authors.lastname: Melia
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vallverdu
authors.forename: Mathieu
authors.initials: M
authors.lastname: Jospin
authors.forename: Jose Fernando
authors.initials: JF
authors.lastname: Valencia
authors.forename: Erik W
authors.initials: EW
authors.lastname: Jensen
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Gambus
authors.forename: Alexandre
authors.initials: A
authors.lastname: Perera Lluna
authors.forename: Pere
authors.initials: P
authors.lastname: Caminal
mesh_terms: D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology*; D016292:Procedural Sedation; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D056726:Genetic Association Studies; D006801:Humans; D059225:Nociception / Q000187:drug effects; D059408:Pain Management; D010880:Piperidines / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide; D015742:Propofol; D017450:Receptors, Opioid, mu / Q000235:genetics*; D000077208:Remifentanil; D017422:Sequence Analysis, DNA
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D010880:Piperidines; D017450:Receptors, Opioid, mu; D000077208:Remifentanil; D015742:Propofol