title: Magnesium-induced recurarisation after reversal of rocuronium-induced neuromuscular block with sugammadex.
abstract: A 61-year-old woman (57 kg, 171 cm) underwent surgery under general anaesthesia with desflurane 5.8-6.1 vol. % end-tidal, remifentanil 0.2-0.4 μg/kg/min and rocuronium 35 mg (0.61 mg/kg). On return of the second twitch in the train-of-four (TOF) stimulation measured by acceleromyography, sugammadex 120 mg (2.1 mg/kg) was given. After complete neuromuscular recovery, magnesium sulphate 3600 mg (60 mg/kg) was injected intravenously over 5 min to treat atrial fibrillation. This was associated with recurarisation with a nadir [first twitch=25%, TOF ratio (TOFR)=67%] 7 min after the start of the magnesium sulphate infusion (magnesium plasma level: 2.67 mM). A spontaneous twitch value and a TOFR of >90% were observed 45 min after the beginning of the magnesium sulphate infusion under general anaesthesia. Rapid infusion of magnesium sulphate may re-establish a sugammadex-reversed, rocuronium-induced neuromuscular block during general anaesthesia, probably because of the high plasma level of magnesium (2.67 mM). Desflurane and a small fraction of unbound rocuronium may amplify the known muscle relaxing effects of magnesium. Intravenous injection of magnesium sulphate is not recommended in patients after general anaesthesia with neuromuscular relaxants, particularly after sugammadex reversal. Quantitative neuromuscular monitoring should be used for reversing aminosteroid muscle relaxants with sugammadex--particularly in combination with magnesium injection--to prevent post-operative residual curarisation.
authors.affiliation: Department of Anaesthesiology, University Medical Centre Regensburg, Regensburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Unterbuchner
authors.forename: R
authors.initials: R
authors.lastname: Ziegleder
authors.forename: B
authors.initials: B
authors.lastname: Graf
authors.forename: T
authors.initials: T
authors.lastname: Metterlein
mesh_terms: D000732:Androstanols / Q000037:antagonists & inhibitors*; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy*; D008278:Magnesium Sulfate / Q000009:adverse effects*; D008875:Middle Aged; D019148:Neuromuscular Blockade; D061886:Neuromuscular Monitoring; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D008278:Magnesium Sulfate; D000077123:Rocuronium