title: Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice.
abstract: BACKGROUND
  Pogostemon benghalensis has been used traditionally as anticancer in India.
  
  
  OBJECTIVE
  The present study was undertaken to investigate the antitumor activity of hydroethanolic extract of P. benghalensis (HEEPB) and aqueous extract of P. benghalensis (AEPB) on ehrlich ascites carcinoma (EAC) tumor bearing mice.
  
  
  METHODS
  For antitumor effect, treatments with HEEPB and AEPB at doses of 250 mg/kg and 500 mg/kg/day orally were started after 24 h of intraperitoneal inoculation of EAC cells. After the treatment period, median survival time (MST), hematological parameters and solid tumor volume were used to evaluate antitumor activity of the extracts.
  
  
  RESULTS
  Both, HEEPB and AEPB, have increased MST (P<0.05), reduced solid tumor volume (P<0.05) and normalized hematological parameters (P<0.05) significantly.
  
  
  CONCLUSIONS
  As HEEPB and AEPB were effective in reducing the severity of morphological and biochemical parameters induced by EAC cells, this study justifies the traditional use of this plant in cancer.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, India.
authors.forename: Manish S
authors.initials: MS
authors.lastname: Patel
authors.forename: Bhavesh V
authors.initials: BV
authors.lastname: Antala
authors.forename: Ena
authors.initials: E
authors.lastname: Dowerah
authors.forename: Raju
authors.initials: R
authors.lastname: Senthilkumar
authors.forename: Mangala
authors.initials: M
authors.lastname: Lahkar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D000975:Antioxidants / Q000378:metabolism; D019661:Apiaceae / Q000737:chemistry*; D002277:Carcinoma / Q000188:drug therapy*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004058:Diffusion; D004354:Drug Screening Assays, Antitumor; D000431:Ethanol; D005260:Female; D007194:India; D051379:Mice; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010936:Plant Extracts; D000431:Ethanol