title: Catalase C-262T polymorphism and risk of prostate cancer: evidence from meta-analysis.
abstract: Catalase is an important endogenous antioxidant enzyme that detoxifies hydrogen peroxide to oxygen and water, thus limiting the deleterious effects of reactive oxygen species. Several studies investigated the role of the Catalase (CAT) C-262T gene polymorphism on the risk of prostate cancer (PCa), but get conflicting results. We performed a meta-analysis based on five studies, to determine whether Catalase C-262T polymorphism contributes to the risk of prostate cancer using odds ratios (OR) with 95% confidence intervals (CI). On the whole, our evidence indicates that CAT C-262T polymorphism significantly increases PCa risk in the allele comparison model (OR=1.094, 95% CI=1.015-1.178, P=0.018). In the stratified analysis by ethnicity, the same results are found among Caucasians (allele model, OR=1.090, 95% CI=1.009-1.177, P=0.028, dominant model, OR=1.108, 95% CI=1.023-1.201, P=0.012, recessive model, OR=1.379, 95% CI=1.158-1.641, P=0.000, homozygous model, OR=1.429, 95% CI=1.196-1.707, P=0.000, and heterozygote model, OR=1.224, 95% CI=1.020-1.469, P=0.030). In conclusion, this meta-analysis suggests a positive correlation between Catalase C-262T polymorphism and the development of PCa.
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Jieping
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Fupeng
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Shimiao
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China.
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Shang
authors.affiliation: Department of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, 23 Pingjiang Road, Hexi District, Tianjin 300211, China. Electronic address: niuyuanjie2012@sina.com.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Niu
mesh_terms: D016022:Case-Control Studies; D002374:Catalase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: D002374:Catalase
keywords: Catalase; Meta-analysis; Polymorphism; Prostate cancer