title: Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia.
abstract: OBJECTIVE
  We aimed to investigate the relationship of maternal serum levels of S100-B, PAPP-A and IL-6 with severe preeclampsia.
  
  
  METHODS
  This prospective case-control study consisted of 27 severe preeclamptic and 36 healthy singleton pregnancies. The groups were matched for parity, maternal age and body mass index. Maternal blood sampling for S100B, PAPP-A and IL-6 was performed at the morning after an overnight fasting.
  
  
  RESULTS
  S100-B concentrations were significantly higher in severe preeclampsia group (0.09 ± 0.05 vs. 0.13 ± 0.01 µg/L; p = 0.025). PAPP-A levels were higher (196.54 ± 21.56 vs. 208.80 ± 23.97 mIU/ml; p = 0.707) and IL-6 levels were lower in severe preeclamptic group (68.79 ± 29.89 vs. 37.30 ± 6.46 pg/ml; p = 0.372). AUC value for S100-B was calculated as 0.712. When cutoff level for serum S100-B for predicting severe preeclampsia was regarded as 0.0975 µg/L, sensitivity and specificity were found to be 81.4 % and 58.3 %, respectively. Pregnancies with ≥0.0975 µg/L S100-B levels had 12.75-fold increased risk for having CNS symptoms (OR 12.75; 95 % CI 2.69-60.28) and 3.27-fold increased risk for having HELLP syndrome (OR 3.27; 95 % CI 0.62-17.36).
  
  
  CONCLUSIONS
  Our results suggest that serum S100B levels may be a potential marker in severe preeclampsia for the severity of hypoperfusion both in placenta and brain pointing at subsequent risk of organ failure.
authors.affiliation: Department of Obstetrics and Gynecology, Celal Bayar University, Manisa, Turkey, artunc.burcu@gmail.com.
authors.forename: Burcu
authors.initials: B
authors.lastname: Artunc-Ulkumen
authors.forename: Yesim
authors.initials: Y
authors.lastname: Guvenc
authors.forename: Asli
authors.initials: A
authors.lastname: Goker
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Gozukara
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D017359:HELLP Syndrome / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D010920:Placenta / Q000473:pathology; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D011266:Pregnancy-Associated Plasma Protein-A