title: 6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms.
abstract: We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to n-copies of thiol-peptide in-solution to obtain two/four/eight-armed dendrimers. Using 'n' number of bromomaleimide analogues, 2(n) ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes.
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences and ‡School of Chemistry and Physics, University of KwaZulu-Natal , Durban 4001, South Africa.
authors.forename: Suhas
authors.initials: S
authors.lastname: Ramesh
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Cherkupally
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: de la Torre
mesh_terms: D000595:Amino Acid Sequence; D002208:Caproates / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C000596454:6-(bromomaleimido)hexanoic acid; D002208:Caproates; D010455:Peptides; C037652:hexanoic acid