title: A case of PSF-TFE3 gene fusion in Xp11.2 renal cell carcinoma with melanotic features.
abstract: Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) with PSF-TFE3 gene fusion is a rare neoplasm. Only 22 cases of Xp11.2 RCCs with PSF-TFE3 have been reported to date. We describe an additional case of Xp11.2 RCC with PSF-TFE3 showing melanotic features. Microscopically, the histologic features mimic clear cell renal cell carcinoma. However, the dark-brown pigments were identified and could be demonstrated as melanins. Immunohistochemically, the tumor cells were widely positive for CD10, human melanoma black 45, and TFE3 but negative for cytokeratins, vimentin, Melan-A, microphthalmia-associated transcription factor, smooth muscle actin, and S-100 protein. Genetically, we demonstrated PSF-TFE3 fusion between exon 9 of PSF and exon 5 of TFE3. The patient was free of disease with 50 months of follow-up. The prognosis of this type of tumor requires more cases because of limited number of cases and follow-up period. Xp11.2 RCC with PSF-TFE3 inevitably requires differentiation from other kidney neoplasms. Immunohistochemical and molecular genetic analyses are essential for accurate diagnosis.
authors.affiliation: Department of Pathology, Anhui Medical University, Hefei 230032, China.
authors.forename: He-Qin
authors.initials: HQ
authors.lastname: Zhan
authors.affiliation: Department of Pathology, The First Hospital Fujian Medical University, Fuzhou 350005, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Electronic address: wangchaofu@126.com.
authors.forename: Chao-Fu
authors.initials: CF
authors.lastname: Wang
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Xiong-Zeng
authors.initials: XZ
authors.lastname: Zhu
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D018949:Antigens, CD1 / Q000032:analysis; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000032:analysis / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D050939:Gene Fusion; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000473:pathology*; D009392:Nephrectomy; D012074:Remission Induction; D009418:S100 Proteins / Q000032:analysis; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D018949:Antigens, CD1; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D009418:S100 Proteins; C073119:TAP1 protein, human; C069203:TFE3 protein, human
keywords: Melanotic; PSF-TFE3 gene fusion; Prognosis; Renal cell carcinoma; Xp11.2 translocation