title: Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging.
abstract: We report a facile synthesis of bifunctional Fe3O4-Ag(125)I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). We introduced (125)I, which is a clinically used radioisotope, as a SPECT reporter, into Fe3O4-Ag heterodimer nanoparticles to provide a new type of bifunctional contrast agent for MRI and SPECT imaging.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China. hongwei@suda.edu.cn panyue@suda.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Tian
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Chong
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Deng
authors.forename: Minghua
authors.initials: M
authors.lastname: Tang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Li
authors.forename: Cuicui
authors.initials: C
authors.lastname: Ge
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.forename: Hongwei
authors.initials: H
authors.lastname: Gu
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D019281:Dimerization; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007501:Iron / Q000737:chemistry; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods*; D019047:Phantoms, Imaging; D011868:Radioisotopes / Q000737:chemistry; D013154:Spleen / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D058185:Magnetite Nanoparticles; D011868:Radioisotopes; D006046:Gold; D007501:Iron