title: Biliary tract reconstruction with or without T-tube in orthotopic liver transplantation: a systematic review and meta-analysis.
abstract: BACKGROUND
  At present whether to use T-tube or not during orthotopic liver transplantation (OLT) in biliary tract reconstruction still remains controversial. Most transplant centers choose not to use T-tube because the T-tube can increase the incidence of cholangitis, but some centers still use T-tube because the T-tube can decrease the incidence of anastomotic strictures.
  
  
  OBJECTIVE
  The purpose of this study is to compare biliary complications after biliary tract reconstruction with or without T-tube in OLT.
  
  
  METHODS
  systematic review and meta-analysis of a collection of 15 studies (six randomized control trails (RCTs) and nine comparative studies) to compare biliary complications after biliary tract reconstruction with or without T-tube in OLT.
  
  
  RESULTS
  The data showed that the biliary tract reconstruction with T-tube and without T-tube had equivalent outcomes for overall biliary complications (six RCTs p = 0.76; odd ratio [OR] = 1.19; 95% CI: 0.40, 3.58; all studies p = 0.14; OR = 1.50; 95% CI: 0.88, 2.57), bile leaks (six RCTs p = 0.61; OR = 0.86; 95% CI: 0.49, 1.52; all studies p = 0.09; OR = 1.39; 95% CI: 0.95, 2.02), cholangitis (six RCTs p = 0.13; OR = 5.54; 95% CI: 0.62, 49.79; all studies p = 0.08; OR = 4.27; 95% CI: 0.86, 21.16), hepatic artery thrombosis (two RCTs p = 1.00; OR = 1.00; 95% CI: 0.22, 4.49; all studies p = 0.75; OR = 1.19; 95% CI: 0.41, 3.44). However, in the group with T-tube there were better outcomes for biliary strictures (six RCTs p = 0.0003; OR = 0.34; 95% CI: 0.19, 0.61; all studies p < 0.0001; OR = 0.49; 95% CI: 0.34, 0.69).
  
  
  CONCLUSIONS
  Although most organizations choose not to use T-tube in OLT, we suggest that use of T-tube in biliary tract reconstruction during OLT for the recipients who possibly have high risks of biliary stricture is useful and necessary.
authors.affiliation: Department of Hepatobiliary and Transplantation Surgery, the First Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.forename: Jialin
authors.initials: J
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Chengshuo
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Zhou
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
mesh_terms: D001662:Biliary Tract Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D016009:Chi-Square Distribution; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D016017:Odds Ratio; D011183:Postoperative Complications / Q000517:prevention & control; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
keywords: T-tube; biliary complications; biliary tract reconstruction; meta-analysis; orthotopic liver transplantation