title: Denhaminols A-H, dihydro-β-agarofurans from the endemic Australian rainforest plant Denhamia celastroides.
abstract: Eight new dihydro-β-agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University , Brisbane, QLD 4111, Australia.
authors.forename: Claire
authors.initials: C
authors.lastname: Levrier
authors.forename: Martin C
authors.initials: MC
authors.lastname: Sadowski
authors.forename: Colleen C
authors.initials: CC
authors.lastname: Nelson
authors.forename: Peter C
authors.initials: PC
authors.lastname: Healy
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D001315:Australia; D029753:Celastraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D065947:Rainforest; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C079978:dihydroagarofuran