title: [Post-injection syndrome after depot injection of olanzapine].
abstract: BACKGROUND
  Olanzapine pamoate injection is an anti-psychotic depot to be administered intramuscularly once every 2-4 weeks. A post-injection syndrome may occur shortly after administration, resulting in an acute intoxication with olanzapine.
  
  
  METHODS
  A 42-year-old patient with a schizophrenic disorder lost consciousness 30 min after administration of olanzapine pamoate. He was admitted to a nearby hospital with tachycardia, hypotension, pin-point pupils and respiratory distress leading to reduced oxygen saturation. He was ventilated during one night and recovered within 2 days.
  
  
  CONCLUSIONS
  A post-injection syndrome may develop after administration of olanzapine pamoate when the entire dose olanzapine is released at once from the muscle. Therefore, the patient should be observed for at least 3 hours after every injection. The risk of a post-injection syndrome and the necessary observation period should to be taken into account when deciding to start treatment with olanzapine pamoate depot.
authors.affiliation: Apotheek Haagse Ziekenhuizen, afd. Klinisch-farmaceutisch en Toxicologisch Laboratorium, Den Haag.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Wilms
authors.forename: Marijke T
authors.initials: MT
authors.lastname: van der Velden
authors.forename: Fred H
authors.initials: FH
authors.lastname: van Essen
authors.forename: Celine
authors.initials: C
authors.lastname: ten Brink
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D008297:Male; D000077152:Olanzapine; D012559:Schizophrenia / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine