title: Synthesis of unsymmetrical pyrazines based on α-diazo oxime ethers.
abstract: Synthesis of unsymmetrically substituted pyrazines has been a challenge. The reactivity of α-imino carbenoids derived from α-diazo oxime ethers has been exploited for pyrazine synthesis, in which the reaction of α-diazo oxime ethers with 2H-azirines provides highly substituted pyrazines in good to excellent yields.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore 637616, Singapore.
authors.forename: Nicole S Y
authors.initials: NS
authors.lastname: Loy
authors.forename: Sunggak
authors.initials: S
authors.lastname: Kim
authors.forename: Cheol-Min
authors.initials: CM
authors.lastname: Park
mesh_terms: D001389:Azirines / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001389:Azirines; D001391:Azo Compounds; D004987:Ethers; D010091:Oximes; D011719:Pyrazines