title: Peroxisystem: harnessing systems cell biology to study peroxisomes.
abstract: In recent years, high-throughput experimentation with quantitative analysis and modelling of cells, recently dubbed systems cell biology, has been harnessed to study the organisation and dynamics of simple biological systems. Here, we suggest that the peroxisome, a fascinating dynamic organelle, can be used as a good candidate for studying a complete biological system. We discuss several aspects of peroxisomes that can be studied using high-throughput systematic approaches and be integrated into a predictive model. Such approaches can be used in the future to study and understand how a more complex biological system, like a cell and maybe even ultimately a whole organism, works.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Schuldiner
authors.forename: Einat
authors.initials: E
authors.lastname: Zalckvar
mesh_terms: D000818:Animals; D003585:Cell Biology; D006801:Humans; D020675:Peroxisomes; D049490:Systems Biology
keywords: High content; Models; Peroxisomes; Screens; Systems cell biology