title: Decoding the processing of lying using functional connectivity MRI.
abstract: BACKGROUND
  Previous functional MRI (fMRI) studies have demonstrated group differences in brain activity between deceptive and honest responses. The functional connectivity network related to lie-telling remains largely uncharacterized.
  
  
  METHODS
  In this study, we designed a lie-telling experiment that emphasized strategy devising. Thirty-two subjects underwent fMRI while responding to questions in a truthful, inverse, or deceitful manner. For each subject, whole-brain functional connectivity networks were constructed from correlations among brain regions for the lie-telling and truth-telling conditions. Then, a multivariate pattern analysis approach was used to distinguish lie-telling from truth-telling based on the functional connectivity networks.
  
  
  RESULTS
  The classification results demonstrated that lie-telling could be differentiated from truth-telling with an accuracy of 82.81% (85.94% for lie-telling, 79.69% for truth-telling). The connectivities related to the fronto-parietal networks, cerebellum and cingulo-opercular networks are most discriminating, implying crucial roles for these three networks in the processing of deception.
  
  
  CONCLUSIONS
  The current study may shed new light on the neural pattern of deception from a functional integration viewpoint.
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China. jiangweixiong68@163.com.|College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, P.R. China. jiangweixiong68@163.com.|Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan, 410205, P.R. China. jiangweixiong68@163.com.
authors.forename: Weixiong
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China. liuhas_20040125@163.com.
authors.forename: Huasheng
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, P.R. China. lingl.zeng@gmail.com.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China. leslie0912@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, P.R. China. shenhui_nudt@126.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: Key Laboratory of Medical Information Research (Central South University), College of Hunan Province, Changsha, Hunan, 410083, P.R. China. Ajlul@sohu.com.
authors.forename: Aijing
authors.initials: A
authors.lastname: Luo
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, P.R. China. dwhu@nudt.edu.cn.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P.R. China. cjr.wangwei@vip.163.com.|Key Laboratory of Medical Information Research (Central South University), College of Hunan Province, Changsha, Hunan, 410083, P.R. China. cjr.wangwei@vip.163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology; D008192:Deception; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D005793:Generalization, Psychological; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology; D011930:Reaction Time; D055815:Young Adult