title: Design of the North Carolina Prostate Cancer Comparative Effectiveness and Survivorship Study (NC ProCESS).
abstract: The North Carolina Prostate Cancer Comparative Effectiveness & Survivorship Study (NC ProCESS) was designed in collaboration with stakeholders to compare the effectiveness of different treatment options for localized prostate cancer. Using the Rapid Case Ascertainment system of the North Carolina Central Cancer Registry, 1,419 patients (57% of eligible) with newly-diagnosed localized prostate cancer were enrolled from January 2011 to June 2013, on average 5 weeks after diagnosis. All participants were enrolled prior to treatment and this population-based cohort is sociodemographically diverse. Prospective follow-up continues to collect data on treatments received, disease control, survival and patient-reported outcomes. This study highlights several important considerations regarding stakeholder involvement, study design and generalizability regarding comparative effectiveness research in prostate cancer.
authors.affiliation: Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Chen
authors.forename: William R
authors.initials: WR
authors.lastname: Carpenter
authors.forename: Mimi
authors.initials: M
authors.lastname: Kim
authors.forename: Laura H
authors.initials: LH
authors.lastname: Hendrix
authors.forename: Robert P
authors.initials: RP
authors.lastname: Agans
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Meyer
authors.forename: Anna
authors.initials: A
authors.lastname: Hoffmeyer
authors.forename: Bryce B
authors.initials: BB
authors.lastname: Reeve
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Nielsen
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Usinger
authors.forename: Tara S
authors.initials: TS
authors.lastname: Strigo
authors.forename: Anne M
authors.initials: AM
authors.lastname: Jackman
authors.forename: Mary
authors.initials: M
authors.lastname: Anderson
authors.forename: Paul A
authors.initials: PA
authors.lastname: Godley
mesh_terms: D000368:Aged; D057186:Comparative Effectiveness Research; D003710:Demography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009657:North Carolina / Q000453:epidemiology; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012042:Registries; D012107:Research Design; D017741:Survivors; D016896:Treatment Outcome
keywords: brachytherapy; comparative effectiveness research; prostate cancer; prostatectomy; radiation