title: Enhanced platelet activity in atrial septal defect.
abstract: OBJECTIVE
  Enhanced platelet activity assessed by mean platelet volume (MPV) was observed in pulmonary arterial hypertension. This study examined the presence of platelet activation in adults with atrial septal defect (ASD), its relationship with pulmonary vascular disease and its changes following device closure of the defects.
  
  
  METHODS
  A total of 76 consecutive patients received transcatheter ASD closure and 40 matched healthy volunteers were prospectively enrolled for blood tests and transthoracic echocardiography (patients: aged 36 ± 13, 37% men; controls: aged 36 ± 8, 38% men). MPV, systolic pulmonary arterial pressures (PAP), and right ventricular end-diastolic diameters were collected before and after ASD closure in patients.
  
  
  RESULTS
  The mean MPV levels were significantly higher in patients than in controls (10.1 ± 1.3 to 8.6 ± 0.9 fl; P < 0.001) at baseline. A moderate, positive correlation was also observed between baseline MPV levels and systolic PAP (r = 0.542, P < 0.001) in patients. Both MPV levels, systolic PAP and right ventricular end-diastolic diameters reduced significantly 6 months following ASD closure. The 6-month MPV and systolic PAP values were comparable to those of the normals.
  
  
  CONCLUSIONS
  Enhanced platelet activity was present in ASD and associated with the presence of pulmonary vascular disease. This phenomenon was largely reversible following device closure of the defects.
authors.affiliation: aDepartment of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey bDivision of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.forename: Deniz
authors.initials: D
authors.lastname: Elcik
authors.forename: Bekir
authors.initials: B
authors.lastname: Calapkorur
authors.forename: Yat-Yin
authors.initials: YY
authors.lastname: Lam
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000628:therapy*; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D015539:Platelet Activation; D011669:Pulmonary Wedge Pressure; D016896:Treatment Outcome; D055815:Young Adult