title: Fluphenazine: from an isolated molecule to its interaction with lipid bilayers.
abstract: Fluphenazine (FPh) belongs to the phenothiazine family of compounds and exhibits a wide variety of biological effects, including antimutagenic, proapoptotic, antiproliferative and anti-multidrug resistance (MDR) activities. The ability of FPh to interact with lipid membranes can have a significant impact on its biological activities. However, the mechanisms involved in the interaction of FPh with lipid membranes are poorly understood. FTIR-ATR spectroscopy has been used in this study to visualize the interactions between FPh and a model lipid bilayer composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Subsequent interpretation of the temperature-dependent FTIR spectra obtained for FPh:DPPC systems containing different concentrations of FPh was efficiently supported by principal component analysis.
authors.affiliation: Department of Chemistry, University of Wrocław, F. Joliot Curie 14, Wrocław 50-383, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Petrus
authors.affiliation: Department of Chemistry, University of Wrocław, F. Joliot Curie 14, Wrocław 50-383, Poland. Electronic address: boguslawa.czarnik@chem.uni.wroc.pl.
authors.forename: Bogusława
authors.initials: B
authors.lastname: Czarnik-Matusewicz
authors.affiliation: Department of Chemistry, University of Wrocław, F. Joliot Curie 14, Wrocław 50-383, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Petrus
authors.affiliation: Department of Chemistry, University of Wrocław, F. Joliot Curie 14, Wrocław 50-383, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Cieślik-Boczula
authors.affiliation: Department of Basic Medical Science, Wrocław Medical University, Borowska 211, Wrocław 50-556, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Jaszczyszyn
authors.affiliation: Department of Basic Medical Science, Wrocław Medical University, Borowska 211, Wrocław 50-556, Poland.
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Gąsiorowski
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D018492:Dopamine Antagonists / Q000737:chemistry*; D005476:Fluphenazine / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D025341:Principal Component Analysis; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D018492:Dopamine Antagonists; D008051:Lipid Bilayers; D015060:1,2-Dipalmitoylphosphatidylcholine; C081581:colfosceril palmitate; D005476:Fluphenazine
keywords: FTIR–ATR spectroscopy; Fluphenazine; Lipid film; Principal component analysis