title: An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis.
abstract: The link between Helicobacter pylori and iron deficiency (ID) or iron deficiency anemia (IDA) has been investigated recently. We suggested that IDA/ID associated with H. pylori infection might be mediated by inflammation-driven hepcidin production. Patients with complaints of recurrent abdominal pain and dyspepsia aged between 7-16 years were included in this study. Patients were divided into two groups according to H. pylori status in upper gastrointestinal endoscopy. Group I who had H. pylori gastritis (n=50) received triple antibiotic therapy. Group II (n=50) who had H. pylori-negative gastritis only received proton pump inhibitor. Thirty healthy children with the similar age and gender were included in the study as a control group. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, prohepcidin and interleukin-6 (IL-6) values were evaluated in all children at the first visit. Initial tests were repeated after H. pylori eradication. Initial levels of ferritin (p=0.002), prohepcidin (p=0.003), and IL-6 (p=0.004) were found significantly lower in group I compared to group II and the control group. The mean prohepcidin level was lower in the anemic H. pylori-positive group than in non-anemic H. pylori-positive group; however, the difference was not statistically significant. While significant increases in hematocrit and mean corpuscular volume were observed, no significant difference was found in serum ferritin, prohepcidin, or IL-6 level after eradication treatment in H. pylori-positive group.
  
  
  CONCLUSIONS
  H. pylori-induced gastritis appears to cause an increase in prohepcidin levels and a decrease in ferritin levels, supporting our hypothesis; but this relationship has not been proven.
authors.affiliation: Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Turkey, drnagehan@yahoo.com.
authors.forename: Nagehan
authors.initials: N
authors.lastname: Emiralioglu
authors.forename: Idil
authors.initials: I
authors.lastname: Yenicesu
authors.forename: Sinan
authors.initials: S
authors.lastname: Sari
authors.forename: Odul
authors.initials: O
authors.lastname: Egritas
authors.forename: Aylar
authors.initials: A
authors.lastname: Poyraz
authors.forename: Ozge Tugce
authors.initials: OT
authors.lastname: Pasaoglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Celik
authors.forename: Buket
authors.initials: B
authors.lastname: Dalgic
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D004909:Erythrocyte Indices; D005260:Female; D005293:Ferritins / Q000097:blood; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D006454:Hemoglobins; D064451:Hepcidins; D015850:Interleukin-6; D054328:Proton Pump Inhibitors; D005293:Ferritins