title: The Outcome and Predictors of Mortality in Patients Therapeutically Cooled Postcardiac Arrest.
abstract: OBJECTIVE
  To review the outcomes of patients postcardiac arrest admitted to a metropolitan intensive care unit (ICU) where therapeutic hypothermia is practiced.
  
  
  METHODS
  Patients admitted from 2004 to 2012 were reviewed. The management protocol included cooling to 33°C for 24 hours. The primary outcome assessed was hospital mortality. Secondary outcome measures included mortality in patients admitted to ICU after in-hospital cardiac arrest (IHCA) when compared to those with out-of-hospital cardiac arrest (OHCA) and to review initial cardiac rhythm as an indicator of mortality.
  
  
  RESULTS
  A total of 330 patients were included. The overall hospital mortality was 58.1%. Hospital mortality was significantly higher in patients who had OHCA when compared to IHCA (62.5% vs 51%; P = .04). Patients who had asystole and pulseless electrical activity (PEA) had a higher mortality when compared to ventricular tachycardia/ventricular fibrillation (VT/VF) arrest (81.7% vs 67.8% vs 41.9%, respectively; P < .01).
  
  
  CONCLUSIONS
  Patients admitted to ICU postcardiac arrest after therapeutic cooling have a high mortality. An initial rhythm of VT/VF confers a mortality benefit when compared to asystole and PEA.
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia Faculty of Medicine, Nursing and Health Sciences, School of Public Health, Monash University, Melbourne, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Botha
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.
authors.forename: Yvette
authors.initials: Y
authors.lastname: O'Brien
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.
authors.forename: Saada
authors.initials: S
authors.lastname: Malouf
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cole
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.
authors.forename: Erum Sahid
authors.initials: ES
authors.lastname: Ansari
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.
authors.forename: Cameron
authors.initials: C
authors.lastname: Green
authors.affiliation: Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia Faculty of Medicine, Nursing and Health Sciences, School of Public Health, Monash University, Melbourne, Victoria, Australia travindranath@hotmail.com.
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Tiruvoipati
mesh_terms: D000368:Aged; D016887:Cardiopulmonary Resuscitation / Q000379:methods* / Q000401:mortality; D004632:Emergency Medical Services; D005260:Female; D006323:Heart Arrest / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: asystole; cardiac arrest; hypothermia; pulseless electrical activity; ventricular fibrillation