title: Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.
abstract: Elucidating the underlying pathogenic pathways in Parkinson's disease will be critical for targeted drug development. In this issue of Neuron, Dhungel et al. (2015) utilize a yeast model to establish a link between VPS35 and EIF4G1 in α-synuclein-related neurodegeneration.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: ross.owen@mayo.edu.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: Casey
authors.initials: C
authors.lastname: Cook
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: petrucelli.leonard@mayo.edu.
authors.forename: Leonard
authors.initials: L
authors.lastname: Petrucelli
mesh_terms: D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D039603:Eukaryotic Initiation Factor-4G / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D033921:Vesicular Transport Proteins / Q000235:genetics*; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D039603:Eukaryotic Initiation Factor-4G; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D051844:alpha-Synuclein