title: Targeting the cellular origin of organ fibrosis.
abstract: Organ fibrosis after injury, which can significantly compromise tissue function, is in part due to proliferation of fibroblasts and myofibroblasts of unclear cellular origin. Now in Cell Stem Cell, Kramann et al. (2015) show that perivascular Gli1+ mesenchymal-stem-cell-like cells generate a large fraction of myofibroblasts in disease conditions.
authors.affiliation: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
authors.forename: Johnny
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: thomas.braun@mpi-bn.mpg.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Braun
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000473:pathology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*
chemical_list: D051741:Kruppel-Like Transcription Factors