title: Effect of therapeutic dose of vitamin d on serum adiponectin and glycemia in vitamin d-insufficient or deficient type 2 diabetic patients.
abstract: BACKGROUND
  Lower vitamin D status has been reported in diabetic patients. Serum 25-hydroxyvitamin D and adiponectin were inversely associated with type 2 diabetes and insulin resistance. Vitamin D may involve in regulation of the adiponectin levels, which is directly related to insulin sensitivity.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of therapeutic dose of vitamin D on serum adiponectin and insulin resistance in vitamin D-insufficient or deficient type 2 diabetic patients.
  
  
  METHODS
  This double-blind, randomized, clinical trial was conducted on 81 type 2 diabetic patients with vitamin D level of 10-30 ng/mL. Intervention was 50000 IU vitamin D or placebo once a week for 8 weeks. At the beginning and end of the study, blood samples were collected after 12 hours of fasting and serum glucose, insulin, 25-hydroxyvitamin D, and adiponectin were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR).
  
  
  RESULTS
  After 8-week intervention, serum 25-hydroxyvitamin D significantly increased and reached the normal levels in patients receiving vitamin D (P < 0.001) and the levels of fasting serum glucose, insulin, and HOMA-IR were significantly decreased (P = 0.04, 0.02 and 0.007, respectively). No significant changes were observed in these levels in the placebo group. Significant differences were observed in mean changes in the above-mentioned variables between the two groups (P = 0.01, 0.04 and 0.006, respectively). No significant changes were found in serum adiponectin in the vitamin D and placebo groups (P = 0.83).
  
  
  CONCLUSIONS
  Therapeutic dose of vitamin D can improve vitamin D status and glycemic indicators. But it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin D on serum adiponectin levels.
authors.affiliation: Department of Clinical Nutrition and Dietetics Therapy, Faculty of Nutrition Sciences and Food Technology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Baziar
authors.affiliation: Department of Clinical Nutrition and Dietetics Therapy, Faculty of Nutrition Sciences and Food Technology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Kurosh
authors.initials: K
authors.lastname: Jafarian
authors.affiliation: Research Center of Endocrinology and Metabolism, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Zhaleh
authors.initials: Z
authors.lastname: Shadman
authors.affiliation: Department of Community Medicine, Alborz University of Medical Sciences, Karaj, IR Iran ; Non Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.affiliation: Research Center of Endocrinology and Metabolism, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Khoshniat Nikoo
authors.affiliation: Research Center of Endocrinology and Metabolism, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mahshid
authors.initials: M
authors.lastname: Abd Mishani
keywords: Adiponectin; Diabetes Mellitus; Insulin Resistance; Vitamin D