title: Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients.
abstract: Leukemia inhibitory factor (LIF) is known to potentiate the differentiation and survival of neuronal and oligodendrocyte precursors. Systemic therapy with LIF reportedly ameliorated the severity of experimental autoimmune encephalomyelitis and prevented oligodendrocyte death. We studied the secreted LIF levels from immune cells of relapsing remitting multiple sclerosis (RR-MS) patients compared to age- and gender-matched healthy controls (HCs). LIF was barely detected in the supernatants when the cells were not stimulated. After stimulation with anti-CD3/CD28 monoclonal antibody, LIF levels were up-regulated in both patients and controls, although to a significantly lower extent in RR-MS patients compared to HC. There were no significant differences between untreated patients and interferon-β1a treated patients. This is a heretofore unreported aspect of immune dysregulation in patients with RR-MS that may be related to insufficient remyelination and neurogenesis in MS lesions.
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Yifat Amir
authors.initials: YA
authors.lastname: Levy
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Karin
authors.initials: K
authors.lastname: Mausner-Fainberg
authors.affiliation: Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Vaknin-Dembinsky
authors.affiliation: Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Tali
authors.initials: T
authors.lastname: Amidror
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Regev
authors.affiliation: Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler's Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: arnonk@tlvmc.gov.il.
authors.forename: Arnon
authors.initials: A
authors.lastname: Karni
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000473:pathology*; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D053605:Leukemia Inhibitory Factor
keywords: Leukemia inhibitory factor; Monocytes; Multiple sclerosis; Neurogenesis; Remyelination; T cells