title: Using synthetic RNAs as scaffolds and regulators.
abstract: The natural versatility of RNA makes it an ideal substrate for bioengineering. Its structural properties and predictable base-pairing permit its use as molecular scaffold, and its ability to interact with nucleic acids, proteins and small molecules confers a regulatory potential that can be harvested to design RNA regulators in diverse contexts.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, and the Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Cameron
authors.initials: C
authors.lastname: Myhrvold
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, and the Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Silver
mesh_terms: D020029:Base Pairing; D057005:Bioengineering / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D012313:RNA