title: Effects of Cream Containing Ficus carica L. Fruit Extract on Skin Parameters: In vivo Evaluation.
abstract: This study was aimed to investigate the effects of cream containing Ficus carica L. fruit (Fig) extract on various skin parameters such as skin melanin, erythema, moisture content, trans-epidermal water loss and sebum. For this purpose, formulation with 4% concentrated extract of F. carica fruit and base without extract were developed. Base served as a control. Both base and formulation were applied to the cheeks of human volunteers for 8 weeks to investigate the effects on different skin parameters using non-invasive bioengineering instruments. Formulation decreased the skin melanin, trans-epidermal water loss and skin sebum significantly. Formulation increased the skin hydration significantly and insignificant effects on skin erythema. We concluded that a stable topical cream (w/o emulsion) containing F. carica fruit extract have effects on skin melanin, trans-epidermal loss, hydration values and sebum content and possibly could be used against for hyper pigmentation, acne, freckles and wrinkle.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan.
authors.forename: H
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Ali
keywords: Ficus carica L; facial cream; non-invasive bioengineering; skin parameters