title: Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae.
abstract: Klebsiella pneumoniae (K. pneumoniae) causing brain abscess in newborn infants is rare. Presented herein, is a 27-day-old male neonate who developed two frontal lobe abscesses in association with K. pneumoniae sepsis and meningitis. Antibiotic susceptibility testing utilizing the double-disk synergy method (Cefotaxime and Amoxycillin-Clavulanate) confirmed the extended spectrum beta-lactamase (ESBL) production by the isolate. He was treated simultaneously with antibiotics (Meropenem and Amikacin) and abscess aspiration through the anterior fontanelle, with less than satisfactory outcome. ESBL producing K. pneumoniae brain abscess in neonates is extremely rare in the English literature. Emperical carbapenems and aminoglycoside coverage in neonates with K. pneumoniae sepsis and brain abscess, especially in areas with high rate of ESBL producing bacteria may be warranted.
authors.affiliation: Assistant Professor, Departments of Pediatrics, Burdwan Medical College and Hospital , Burdwan, West Bengal, India .
authors.forename: Biswajit
authors.initials: B
authors.lastname: Biswas
authors.affiliation: Resident, Departments of Pediatrics, Burdwan Medical College and Hospital , Burdwan, West Bengal, India .
authors.forename: Monojit
authors.initials: M
authors.lastname: Mondal
authors.affiliation: Resident, Department of Pediatrics, Golisano Children's Hospital, Upstate Medical University, 750, E. Adams Street , Syracuse, New York 13210, USA .
authors.forename: Rajoo
authors.initials: R
authors.lastname: Thapa
authors.affiliation: Resident, Department of Pediatrics, St.Mary's Hospital, PO30 5TG Newport , Wales, UK .
authors.forename: Debkrishna
authors.initials: D
authors.lastname: Mallick
authors.affiliation: Professor and Head of the Deptartment, Departments of Pediatrics, Burdwan Medical College and Hospital , Burdwan, West Bengal, India .
authors.forename: Asok Kumar
authors.initials: AK
authors.lastname: Datta
keywords: Brain abscess; ESBL; Klebsiella sepsis