title: Antigiardial activity of glycoproteins and glycopeptides from Ziziphus honey.
abstract: Natural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200 kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values ≤ 25 μg/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.
authors.affiliation: a Environment and Natural Resources Research Institute, National Centre for Research , P.O. Box 6096, Khartoum , Sudan.
authors.forename: Seif Eldin A
authors.initials: SE
authors.lastname: Mohammed
authors.affiliation: b Medicinal and Aromatic Plants Research Institute, National Centre for Research , P.O. Box 2404, Khartoum , Sudan.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Kabashi
authors.affiliation: b Medicinal and Aromatic Plants Research Institute, National Centre for Research , P.O. Box 2404, Khartoum , Sudan.
authors.forename: Waleed S
authors.initials: WS
authors.lastname: Koko
authors.affiliation: c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270 , Pakistan.
authors.forename: M Kamran
authors.initials: MK
authors.lastname: Azim
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects*; D006020:Glycopeptides / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D006722:Honey; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D000981:Antiprotozoal Agents; D006020:Glycopeptides; D006023:Glycoproteins
keywords: Giardia lamblia; antiprotozoal; honey proteins