title: Differences in hemispherical thalamo-cortical causality analysis during resting-state fMRI.
abstract: Thalamus is a very important part of the human brain. It has been reported to act as a relay for the messaging taking place between the cortical and sub-cortical regions of the brain. In the present study, we analyze the functional network between both hemispheres of the brain with the focus on thalamus. We used conditional Granger causality (CGC) and time-resolved partial directed coherence (tPDC) to investigate the functional connectivity. Results of CGC analysis revealed the asymmetry between connection strengths of the bilateral thalamus. Upon testing the functional connectivity of the default-mode network (DMN) at low-frequency fluctuations (LFF) and comparing coherence vectors using Spearman's rank correlation, we found that thalamus is a better source for the signals directed towards the contralateral regions of the brain, however, when thalamus acts as sink, it is a better sink for signals generated from ipsilateral regions of the brain.
authors.forename: Abdul Rauf
authors.initials: AR
authors.lastname: Anwar
authors.forename: Makii
authors.initials: M
authors.lastname: Muthalib
authors.forename: Stephane
authors.initials: S
authors.lastname: Perrey
authors.forename: Stephan
authors.initials: S
authors.lastname: Wolff
authors.forename: Guunther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Ulrich
authors.initials: U
authors.lastname: Heute
authors.forename: Muthuraman
authors.initials: M
authors.lastname: Muthuraman
mesh_terms: D000328:Adult; D015984:Causality; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000502:physiology; D012146:Rest / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*