title: Changes in first trimester screening test parameters in pregnancies complicated by placenta previa and association with hyperemesis gravidarum.
abstract: OBJECTIVE
  To assess the possible changes in first trimester screening test parameters in pregnancies complicated with placenta previa and to determine whether there is an association between hyperemesis gravidarum and placenta previa.
  
  
  METHODS
  A total of 131 singleton spontaneously conceived pregnancies that were complicated by placenta previa and delivered between May 2006 and May 2013 were evaluated from birth charts. Ninety patients without placenta previa were selected amongst patients who delivered within the same period of time as the control group. Cases of low lying placenta (n=52) within the study group were assessed as a separate group. The rest of the cases was considered to be in a different group.
  
  
  RESULTS
  Beta human chorionic gonadotropin (BhCG) multiples of medians (MoMs) and nuchal translucency (NT) MoMs were significantly higher in the placenta previa group in comparison with the low lying placenta and control groups. Apgar scores at both the 1st and 5th minutes were significantly lower in the placenta previa group. Hyperemesis gravidarum was found to be significantly more frequent in the placenta previa group.
  
  
  CONCLUSIONS
  The prevalence of hyperemesis gravidarum in the first trimester is higher in pregnancies complicated by placenta previa. Paying more attention to the development of placenta previa in the routine pregnancy follow-up of patients with hyperemesis gravidarum could be considered.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Fırat
authors.initials: F
authors.lastname: Tülek
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Kahraman
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Taşkın
authors.affiliation: Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Özkavukçu
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Feride
authors.initials: F
authors.lastname: Söylemez
keywords: BhCG; PAPP-A; Placenta previa; first trimester screening; hyperemesis gravidarum