title: Neurological outcome and predictive factors of idiopathic optic neuritis in China.
abstract: BACKGROUND
  The neurological outcome and predictive factors of idiopathic optic neuritis (ION) in China are largely unknown.
  
  
  OBJECTIVE
  The aim of this paper is to study the neurological outcome of Chinese ION and to investigate the early predictors for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD).
  
  
  METHODS
  Retrospective medical record review and supplementary follow-up of 107 ION patients was performed. Statistical analysis of the baseline characteristics as risk factors for ION patients converting into MS or NMOSD was performed.
  
  
  RESULTS
  With an average disease course of 9.5years, 19 of the 107 (17.7%) ION patients developed either MS (9, 8.4%) or NMOSD (10, 9.3%). The estimated 5-year and 10-year combined accumulative risk rates were 14.1% and 26.0%, respectively. Significantly higher estimated accumulative conversion risk was found in female versus male (P=0.047), adult versus children (P=0.032), patients with brain MRI lesions versus patients without leasions (P=0.026), patients with CSF positive oligoclonal bands and/or elevated IgG index versus without (P=0.003) and patients with poor visual recovery versus patients with good recovery (P=0.007). Furthermore, brain white matter lesions and good visual recovery were statistically more common typically in MS converters compared with the NMOSD converters (P=0.01 and P=0.006, respectively).
  
  
  CONCLUSIONS
  The combined conversion rate for ION to MS/NMO in Chinese population was lower than the reported rate for Western countries. In addition to some previously reported high risk factors, white matter lesions on the brain MRI at baseline and good visual recovery were found to be good predictors for Chinese ION converting into MS whereas poor visual recovery with a normal brain MRI suggested a higher likelihood of the ION converting into NMOSD.
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: pengjingting217@163.com.
authors.forename: Jing-ting
authors.initials: JT
authors.lastname: Peng
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: conghengri@163.com.
authors.forename: Heng-ri
authors.initials: HR
authors.lastname: Cong
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: carrie_wow@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Yan
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: weidadedy@126.com.
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Kong
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: hanqiu_j@126.com.
authors.forename: Han-qiu
authors.initials: HQ
authors.lastname: Jiang
authors.affiliation: Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: trweiwenbin@163.com.
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Wei
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China. Electronic address: zxjsusan1@yahoo.com.
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014785:Vision, Ocular; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
chemical_list: D043025:Oligoclonal Bands
keywords: Idiopathic; Multiple sclerosis; Neuromyelitis optica; Optic neuritis; Outcome; Predictive