title: Brain-derived neurotrophic factor in chronic periodontitis.
abstract: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Jôice Dias
authors.initials: JD
authors.lastname: Corrêa
authors.affiliation: Department of Physical Therapy, School of Physical Education, Physical Therapy and Occupational Therapy, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Daniele Sirineu
authors.initials: DS
authors.lastname: Pereira
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Mila Fernandes Moreira
authors.initials: MF
authors.lastname: Madeira
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Celso Martins
authors.initials: CM
authors.lastname: Queiroz-Junior
authors.affiliation: Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Danielle Glória
authors.initials: DG
authors.lastname: Souza
authors.affiliation: Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: José Eustáquio
authors.initials: JE
authors.lastname: Costa
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Professor Alfredo Balena Avenue 110, 30130-100 Belo Horizonte, MG, Brazil.
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil.
authors.forename: Tarcília Aparecida
authors.initials: TA
authors.lastname: da Silva
mesh_terms: D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D005838:Genotype; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000378:metabolism*; D009195:Peroxidase / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C508609:IL10 protein, human; D016753:Interleukin-10; C579455:BDNF protein, human; D009195:Peroxidase