title: Toxic Epidermal Necrolysis During Dronedarone Treatment: First Report of a Severe Serious Adverse Event Of A New Antiarrhythmic Drug.
abstract: A 77-year-old female patient with symptomatic atrial fibrillation with fast ventricular rate despite conventional antiarrhythmic therapy was treated with dronedarone. Five days later, she developed a maculopapulous exanthema and small flaccid blisters, which spread over the common integument predominantly located on the dorsal trunk. Over few days, the patient showed a severe epidermal necrolysis of approximately 30 % of the body area and ultimately died in multiorgan failure. Here, we report a rare case of toxic epidermal necrolysis during treatment with dronedarone leading to patient death.
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany. thomas.gecks@med.uni-jena.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gecks
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Prochnau
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Franz
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Kühnert
authors.affiliation: Department of Dermatology, Jena University Hospital, Erfurter Straße 35, 07740, Jena, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Schliemann
authors.affiliation: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Hans Rainer
authors.initials: HR
authors.lastname: Figulla
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects / Q000031:analogs & derivatives*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001706:Biopsy; D000077764:Dronedarone; D017809:Fatal Outcome; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D009102:Multiple Organ Failure / Q000139:chemically induced; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone
keywords: Dronedarone; Erythema multiforme; Mucosal ulcerations; Stevens–Johnson syndrome; Tachyarrhythmia absoluta; Toxic epidermal necrolysis