title: TLR4 rs1927911, but not TLR2 rs5743708, is associated with atherosclerotic cerebral infarction in the Southern Han population: a case-control study.
abstract: The objective of this study was to explore the association of toll-like receptor (TLR) 4 rs1927911 and TLR2 rs5743708 with atherosclerotic cerebral infarction (ACI) and their effects on blood pressure, fasting blood glucose, and blood lipids in the Han population of Hunan Province. TLR4 rs1927911 and TLR2 rs5743708 were detected by polymerase chain reaction and restriction fragment length polymorphism in 170 patients with ACI and 149 healthy controls. Our results indicated that the genotype and allele frequencies of TLR4 rs1927911 were significantly different between ACI patients and controls, whereas those of TLR2 rs5743708 were not significantly different between the 2 groups. For TLR4 rs1927911, blood pressure, fasting blood sugar, and serum lipid levels were not significantly different among different genotypes in the ACI and control groups. The rs1927911 polymorphism of the TLR4 gene may be a risk factor for ACI in the Southern Han population of Hunan Province; however, it may not be associated with blood pressure, fasting blood sugar, or blood lipids.
authors.affiliation: From the Department of Neurology (YS, HL, LL, NZ, YL), Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Song
authors.forename: Huarong
authors.initials: H
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Long
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D002544:Cerebral Infarction / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications*; D008055:Lipids / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D008055:Lipids; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4