title: Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica.
abstract: An attempt was made to control the surface charge of colloidal silica nanoparticles with 20 nm and 100 nm diameters. Untreated silica nanoparticles were determined to be highly negatively charged and have stable hydrodynamic sizes in a wide pH range. To change the surface to a positively charged form, various coating agents, such as amine containing molecules, multivalent metal cation, or amino acids, were used to treat the colloidal silica nanoparticles. Molecules with chelating amine sites were determined to have high affinity with the silica surface to make agglomerations or gel-like networks. Amino acid coatings resulted in relatively stable silica colloids with a modified surface charge. Three amino acid moiety coatings (L-serine, L-histidine, and L-arginine) exhibited surface charge modifying efficacy of L-histidine > L-arginine > L-serine and hydrodynamic size preservation efficacy of L-serine > L-arginine > L-histidine. The time dependent change in L-arginine coated colloidal silica was investigated by measuring the pattern of the backscattered light in a Turbiscan™. The results indicated that both the 20 nm and 100 nm L-arginine coated silica samples were fairly stable in terms of colloidal homogeneity, showing only slight coalescence and sedimentation.
authors.affiliation: Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea.
authors.forename: Kyoung-Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea.
authors.forename: Hye Min
authors.initials: HM
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Kyungpook National University, Taegu, Republic of Korea.
authors.forename: Won-Jae
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Battelle-Korea Laboratory, International Center for Converging Technology, Korea University, Seoul, Republic of Korea.
authors.forename: Chang-Woo
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Department of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
authors.forename: Tae-il
authors.initials: TI
authors.lastname: Kim
authors.affiliation: Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, Republic of Korea.
authors.forename: Jong-Kwon
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, Republic of Korea.
authors.forename: Jayoung
authors.initials: J
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, Kyungpook National University, Taegu, Republic of Korea.
authors.forename: Seung-Min
authors.initials: SM
authors.lastname: Paek
authors.affiliation: Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Oh
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D003102:Colloids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000596:Amino Acids; D003102:Colloids; D012822:Silicon Dioxide
keywords: amino acids; colloidal stability; nanoparticles; silica; surface charge; turbidity