title: Lipid profile changes in patients undergoing bariatric surgery: a comparative study between sleeve gastrectomy and mini-gastric bypass.
abstract: OBJECTIVE
  To prospectively evaluate the effect of different types of bariatric surgery on lipid profile.
  
  
  METHODS
  Total cholesterol (TC), High-Density-Lipoprotein cholesterol (HDLc), Low-Density-Lipoprotein cholesterol (LDLc) and triglycerides (TG) levels were evaluated before surgery and at 3 different post-operative time-points (3, 6 and 12 months) in consecutive obese subjects undergoing mini-gastric bypass (MGB) or sleeve gastrectomy (SG).
  
  
  RESULTS
  At baseline, 74 MGB and 86 SG subjects were comparable for lipid profile and prevalence of hypercholesterolemia/hypertriglyceridemia. During the post-operative follow-up, both MGB and SG subjects showed significant changes in lipid profile. However, at 3 months, MGB patients showed higher changes in TC (β = 0.179, p = 0.022) and TG (β = 0.265, p = 0.001) than those undergoing SG. At 6-month post-operative follow-up, these differences were confirmed only for TC. After a 12-month follow-up, MGB and SG were entirely comparable for changes in lipid profile with the exception of HDLc, whose changes were higher in SG group (β = 0.130, p = 0.039). Overall, the probability to normalize lipid profile during the 12-month follow-up was similar in MGB and in SG patients (OR:1.24, 95%CI:0.41-3.76, p = 0.689).
  
  
  CONCLUSIONS
  Despites some differences at 3-6 post-operative months, during a 12-month follow-up, SG and MGB showed a similar efficacy in the improvement of lipid profile of obese patients.
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy. Electronic address: milone.marco@alice.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Milone
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Lupoli
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Maietta
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Minno
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bianco
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ambrosino
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Coretti
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Milone
authors.affiliation: Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
authors.forename: Matteo Nicola Dario
authors.initials: MN
authors.lastname: Di Minno
authors.affiliation: Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Musella
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D011184:Postoperative Period; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides
keywords: Bariatric surgery; Lipid profile; Obesity