title: Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support.
abstract: The objective of this work was to conduct pre-clinical feasibility studies to determine if a highly efficient, active-mixing, adult extracorporeal carbon dioxide removal (ECCO2R) system can safely be translated to the pediatric population. The Hemolung Respiratory Assist System (RAS) was tested in vitro and in vivo to evaluate its performance for pediatric veno-venous applications. The Hemolung RAS operates at blood flows of 350-550 ml/min and utilizes an integrated pump-gas exchange cartridge with a membrane surface area of 0.59 m² as the only component of the extracorporeal circuit. Both acute and seven-day chronic in vivo tests were conducted in healthy juvenile sheep using a veno-venous cannulation strategy adapted to the in vivo model. The Hemolung RAS was found to have gas exchange and pumping capabilities relevant to patients weighing 3-25 kg. Seven-day animal studies in juvenile sheep demonstrated that veno-venous extracorporeal support could be used safely and effectively with no significant adverse reactions related to device operation.
authors.affiliation: 2 McGowan Institute for Regenerative Medicine, Pittsburgh, PA - USA.
authors.forename: R Garrett
authors.initials: RG
authors.lastname: Jeffries
authors.forename: Yerbol
authors.initials: Y
authors.lastname: Mussin
authors.forename: Denis S
authors.initials: DS
authors.lastname: Bulanin
authors.forename: Laura W
authors.initials: LW
authors.lastname: Lund
authors.forename: Ergin
authors.initials: E
authors.lastname: Kocyildirim
authors.forename: Zhaksybay Zh
authors.initials: ZZh
authors.lastname: Zhumadilov
authors.forename: Farkhad S
authors.initials: FS
authors.lastname: Olzhayev
authors.forename: William J
authors.initials: WJ
authors.lastname: Federspiel
authors.forename: Peter D
authors.initials: PD
authors.lastname: Wearden
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D001783:Blood Flow Velocity; D001835:Body Weight; D002245:Carbon Dioxide / Q000097:blood*; D002648:Child; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000295:instrumentation*; D005240:Feasibility Studies; D006440:Hemofiltration / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D023421:Models, Animal; D011659:Pulmonary Gas Exchange; D012756:Sheep; D013499:Surface Properties; D013997:Time Factors
chemical_list: D008567:Membranes, Artificial; D002245:Carbon Dioxide