title: Prosthetic devices with nanostructurated surfaces for increased resistance to microbial colonization.
abstract: This review highlights and discusses the impact of nanotechnology on the inhibition of microbial colonization and biofilm development on modified surface prosthetic devices. In the first part of the paper the current status of infections related to prosthetic devices and the inquiries resulting from the increased number of patients with these infections are briefly reviewed. Next we discuss several aspects about the implication of nanotechnology in prosthetic devices surface modification and its impact on the prevention of infections. The main aspects regarding the biocompatibility and the application of these nanomodified prosthetic devices in tissue engineering are also highlighted.
authors.forename: Alina M
authors.initials: AM
authors.lastname: Holban
authors.forename: Alexey
authors.initials: A
authors.lastname: Iordanskii
authors.forename: Alexandru M
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Anna
authors.initials: A
authors.lastname: Bychkova
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.forename: Laurențiu
authors.initials: L
authors.lastname: Mogoantă
authors.forename: George D
authors.initials: GD
authors.lastname: Mogoșanu
authors.affiliation: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, 011061 Bucharest, Romania. grumezescu@yahoo.com.
authors.forename: Florin
authors.initials: F
authors.lastname: Iordache
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D001672:Biocompatible Materials; D018441:Biofilms / Q000254:growth & development; D006801:Humans; D009181:Mycoses / Q000517:prevention & control; D049329:Nanostructures; D036103:Nanotechnology; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials