title: CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia [3] Monash Haematology, Monash Health, Clayton, Victoria, Australia.
authors.forename: G P
authors.initials: GP
authors.lastname: Gregory
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: S J
authors.initials: SJ
authors.lastname: Hogg
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: L M
authors.initials: LM
authors.lastname: Kats
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: E
authors.initials: E
authors.lastname: Vidacs
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Baker
authors.affiliation: 1] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia [2] Cancer Epigenetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: O
authors.initials: O
authors.lastname: Gilan
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Lefebure
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: B P
authors.initials: BP
authors.lastname: Martin
authors.affiliation: 1] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia [2] Cancer Epigenetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Dawson
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: R W
authors.initials: RW
authors.lastname: Johnstone
authors.affiliation: 1] Gene Regulation Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia [3] Monash Haematology, Monash Health, Clayton, Victoria, Australia [4] School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Shortt
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002478:Cells, Cultured; D003497:Cyclic N-Oxides; D042863:Cyclin-Dependent Kinase 9 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007212:Indolizines; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D011726:Pyridinium Compounds / Q000494:pharmacology*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D003497:Cyclic N-Oxides; D007212:Indolizines; C579095:MCL1 protein, human; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D016271:Proto-Oncogene Proteins c-myc; D011726:Pyridinium Compounds; C553669:dinaciclib; D042863:Cyclin-Dependent Kinase 9