title: Robo3: the road taken.
abstract: Although axon guidance mechanisms are well conserved across the animal kingdom, neuronal circuit complexity increases dramatically in evolution. Reporting recently in Neuron, Zelina et al. (2014) uncover mammalian-specific changes in Robo3 that result in a switch from repellent to attractive signaling and may have contributed to increased mammalian circuit complexity.
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada.
authors.forename: Ian V
authors.initials: IV
authors.lastname: Beamish
authors.affiliation: Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada. Electronic address: timothy.kennedy@mcgill.ca.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D005075:Biological Evolution; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface