title: Structure and properties of PLLA/β-TCP nanocomposite scaffolds for bone tissue engineering.
abstract: One of the key components of tissue engineering is a scaffold with suitable morphology, outstanding mechanical properties, and favorable biocompatibility. In this study, β-tricalcium phosphate (β-TCP) nanoparticles were synthesized and incorporated with poly(L-lactic acid) (PLLA) to fabricate nanocomposite scaffolds by the thermally induced phase separation method. The PLLA/β-TCP nanocomposite scaffolds showed a continuous nanofibrous PLLA matrix with strut diameters of 100-750 nm, interconnected micropores with pore diameters in the range of 0.5-10 μm, and high porosity (>92 %). β-TCP nanoparticles were homogeneously dispersed in the PLLA matrix, which significantly improved the compressive modulus and protein adsorption capacity. The prepared nanocomposite scaffolds provided a suitable microenvironment for osteoblast attachment and proliferation, demonstrating the potential of the PLLA/β-TCP nanocomposite scaffolds in bone tissue engineering applications.
authors.affiliation: Institute of Polymer Materials, Qingdao University, Qingdao, 266071, China, taolou72@aliyun.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Lou
authors.forename: Xuejun
authors.initials: X
authors.lastname: Wang
authors.forename: Guojun
authors.initials: G
authors.lastname: Song
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000473:pathology*; D002130:Calcium Phosphates / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D019245:Compressive Strength; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry; D010006:Osteoblasts / Q000378:metabolism; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C485817:beta-tricalcium phosphate; D019344:Lactic Acid; C033616:poly(lactide)