title: Does metabolic syndrome increase the risk of infective complications after prostate biopsy? A critical evaluation.
abstract: OBJECTIVE
  To evaluate the possible association between metabolic syndrome (MetS) and infectious complications after prostate biopsy.
  
  
  METHODS
  A total of 480 men underwent prostatic biopsy due to elevated prostate-specific antigen levels and/or abnormal digital rectal examination. Patients were divided into two subgroups with respect to the presence or absence of MetS. Patients in both groups were closely followed with respect to infectious complications after biopsy and the possible effect of MetS as a certain risk factor on these complications was evaluated with a multivariate analysis.
  
  
  RESULTS
  Infectious complications were observed in 33 cases (6.8%), while urinary tract infection (UTI) was detected in 30 (6.2%) cases, sepsis occurred in three (0.6%) cases. The percentage of the cases with infectious complications was 11.0 and 3.4% in men with and without MetS, respectively (p = 0.002). These rates were 3.7 versus 1.5%, respectively, for UTI (p < 0.003) and 0.9 versus 0.4%, respectively, for sepsis in both groups (p = 0.594). Multivariate analysis of the data confirmed that MetS was associated with an increased risk of infective complications (odds ratio 3.44 and 95% CI 1.56-7.58, p < 0.002) after this procedure.
  
  
  CONCLUSIONS
  MetS could pose a certain increased risk for infectious complications after prostate biopsy. Patients with MetS should be considered as risk cases for this procedure, and they should be evaluated and followed in a very close manner with respect to these complications.
authors.affiliation: Department of Urology, Dr. Lutfi KIRDAR Research and Training Hospital, Istanbul, Turkey, cahitsahin129@gmail.com.
authors.forename: Cahit
authors.initials: C
authors.lastname: Sahin
authors.forename: Bilal
authors.initials: B
authors.lastname: Eryildirim
authors.forename: A Cihangir
authors.initials: AC
authors.lastname: Cetinel
authors.forename: Gokhan
authors.initials: G
authors.lastname: Faydaci
authors.forename: Fehmi
authors.initials: F
authors.lastname: Narter
authors.forename: Cemal
authors.initials: C
authors.lastname: Goktas
authors.forename: Kemal
authors.initials: K
authors.lastname: Sarica
mesh_terms: D000368:Aged; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000382:microbiology