title: Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling.
abstract: Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling.
authors.affiliation: Department of Zoology, Stockholm University , Stockholm , Sweden.
authors.forename: Dick R
authors.initials: DR
authors.lastname: Nässel
authors.affiliation: Functional Pharmacology, Department of Neuroscience, Uppsala University , Uppsala , Sweden.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Williams
keywords: aggression; feeding; intestinal function; locomotion; neuropeptide; peptide hormone