title: Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide.
abstract: The aim of this study was to develop self emulsifying drug delivery systems (SEDDS) of glipizide and to convert it into solid SEDDS (S-SEDDS) using Syloid(®) 244 FP as adsorbent. Solubility study, ternary phase diagram, robustness to dilution, thermodynamic stability study and globule size analysis were adopted to optimize liquid SEDDS. S-SEDDS were evaluated for various studies including in vivo study. The optimized liquid SEDDS formulation consisted of phosphatidylcholine, Tween 80 and Transcutol P as oil, surfactant and cosolvent. In vivo study demonstrated that blood glucose levels were efficiently controlled with S-SEDDS compared with pure drug. The results of this study suggest the potential use of developed S-SEDDS formulation for the delivery of poorly water-soluble drug glipizide.
authors.affiliation: Cachet Pharmaceutical Pvt. Ltd, An ALKEM Group, Baddi, Solan 173205, India. Electronic address: royalanuj@yahoo.co.in.
authors.forename: Anuj G
authors.initials: AG
authors.lastname: Agrawal
authors.affiliation: Cachet Pharmaceutical Pvt. Ltd, An ALKEM Group, Baddi, Solan 173205, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Thane 421003, India.
authors.forename: Paraag S
authors.initials: PS
authors.lastname: Gide
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D004655:Emulsions / Q000737:chemistry; D005913:Glipizide / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties
chemical_list: D004655:Emulsions; D012822:Silicon Dioxide; D005913:Glipizide
keywords: Bioavailability; Glipizide; Poorly water-soluble drug; Self emulsifying drug delivery system; Surfactant