title: Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy.
abstract: Multifunctional nanostructures with both diagnostic and therapeutic capabilities have attracted considerable attention in biomedical research because they can offer great advantages in disease management and prognosis. In this work, a facile way to transfer the hydrophobic iron oxide (IO) nanoparticles into aqueous media by employing carboxylic graphene oxide (GO-COOH) as the transferring agent has been reported. In this one-step process, IO nanoparticles adhere to GO-COOH and form water-dispersible clusters via hydrophobic interactions between the hydrophobic ligands of IO nanoparticles and the basal plane of GO-COOH. The multiple IO nanoparticles on GO-COOH sheets (IO/GO-COOH) present a significant increase in T2 contrast enhancement. Moreover, the IO/GO-COOH nanoclusters also display a high photothermal conversion efficiency and can effectively inhibit tumor growth through the photothermal effects. It is envisioned that such IO/GO-COOH nanocomposites combining efficient MRI and photothermal therapy hold great promise in theranostic applications.
authors.affiliation: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn.
authors.forename: Guoming
authors.initials: G
authors.lastname: Huang
authors.forename: Xianglong
authors.initials: X
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Lirong
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Chi
authors.forename: Jiahe
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Jinhao
authors.initials: J
authors.lastname: Gao
mesh_terms: D000818:Animals; D019343:Citric Acid / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D006108:Graphite / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D053761:Nanocomposites / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D019047:Phantoms, Imaging; D010789:Phototherapy; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010087:Oxides; D014867:Water; C000499:ferric oxide; D019343:Citric Acid; D006108:Graphite