title: Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.
abstract: BACKGROUND
  We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk.
  
  
  OBJECTIVE
  The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT).
  
  
  METHODS
  The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235).
  
  
  RESULTS
  The area under the curve for ASSIST was greater than that of IL6 and PCT.
  
  
  CONCLUSIONS
  ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.
authors.affiliation: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation , Cincinnati, OH , USA .
authors.forename: Hector R
authors.initials: HR
authors.lastname: Wong
authors.forename: Keith R
authors.initials: KR
authors.lastname: Walley
authors.forename: Ville
authors.initials: V
authors.lastname: Pettilä
authors.forename: Nuala J
authors.initials: NJ
authors.lastname: Meyer
authors.forename: James A
authors.initials: JA
authors.lastname: Russell
authors.forename: Sari
authors.initials: S
authors.lastname: Karlsson
authors.forename: Michael G S
authors.initials: MG
authors.lastname: Shashaty
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lindsell
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: Biomarkers; decision tree; modeling; outcome; sepsis; stratification