title: Helping CAR T cells reach tumors.
abstract: CAR T cells have shown dramatic effects against blood cancers, but they have had little impact on solid tumors. Researchers increased the effectiveness of CAR T-cell therapy in solid tumors by injecting the cells near the tumors. A phase I trial using this approach will begin early next year.
mesh_terms: D000818:Animals; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins