title: [Prophylactic salpingectomy or salpingo-oophorectomy as an ovarian cancer prevention?].
abstract: A recent hypothesis has stated that many ovarian cancers (especially high-grade serous histotype) could arise from the distal part of the fallopian tube. On one hand we know that risk-reducing salpingo-oophorectomy is the most effective prevention for ovarian cancer among BRCA mutation carriers. On the other, oophorectomy increases the relative risk for cardiovascular, osteoporotic psychosexual and cognitive dysfunctions in premenopausal women. This raises the question whether bilateral salpingectomy could be an effective strategy in the prevention of ovarian cancer in case of hereditary predisposition and in the general population. Here we discuss origin of ovarian cancer in the light of the latest molecular studies and the relative risks and benefits of a strategy of exclusive salpingectomy in comparison with the classical adnexectomy.
authors.affiliation: CHU Lyon Est, hôpital femme mère enfant, département de gynécologie-obstétrique, université Claude-Bernard Lyon 1, 69000 Lyon, France. Electronic address: gautier.chene@chu-lyon.fr.
authors.forename: Gautier
authors.initials: G
authors.lastname: Chene
authors.affiliation: CHU Lyon Est, hôpital femme mère enfant, département de gynécologie-obstétrique, université Claude-Bernard Lyon 1, 69000 Lyon, France.
authors.forename: Gery
authors.initials: G
authors.lastname: Lamblin
authors.affiliation: CHU Lyon Est, hôpital femme mère enfant, département de gynécologie-obstétrique, université Claude-Bernard Lyon 1, 69000 Lyon, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Le Bail-Carval
authors.affiliation: CHU Lyon Est, hôpital femme mère enfant, département de gynécologie-obstétrique, université Claude-Bernard Lyon 1, 69000 Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chabert
authors.affiliation: Université Claude-Bernard Lyon 1, département de gynécologie-obstétrique, centre hospitalier Lyon Sud, 69000 Lyon, France.
authors.forename: François
authors.initials: F
authors.lastname: Golfier
authors.affiliation: Centre Jean-Perrin, département de chirurgie, 63000 Clermont-Ferrand, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Dauplat
authors.affiliation: Mount Sinai School of Medicine, département de pathologie, 10029 New York, États-Unis.
authors.forename: Liane
authors.initials: L
authors.lastname: Deligdisch
authors.affiliation: Centre Jean-Perrin, département d'anatomie et cytologie pathologiques, 63000 Clermont-Ferrand, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault-Llorca
authors.affiliation: CHU Lyon Est, hôpital femme mère enfant, département de gynécologie-obstétrique, université Claude-Bernard Lyon 1, 69000 Lyon, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Mellier
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D018269:Carcinoma, Endometrioid / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D060787:Neoplasm Grading; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D010052:Ovariectomy; D011322:Primary Prevention / Q000379:methods*; D058994:Salpingectomy / Q000379:methods