title: Acute lower limb ischemia complicating pemetrexed and carboplatin combination chemotherapy for malignant pleural mesothelioma.
abstract: Pemetrexed and Carboplatin are two well-known chemioterapic agents used for the treatment of many tumors, especially for lung cancer and mesothelioma. Peripheral ischemic events related to Pemetrexed and Carboplatin are rarely reported. We herein report a case of lower limb acute ischemia related to combined treatment of Pemetrexed and Carboplatin. A 68-year-old woman was given the chemiotherapic treatment with combination of Pemetrexed and Carboplatin after pleural resection for a malignant pleural mesothelioma. Immediately after the second cycle of treatment, the patient experienced sudden acute left lower limb ischemia. Symptoms resolved after an intra-operative thrombolytic and spasmolytic therapy.
authors.forename: Serena
authors.initials: S
authors.lastname: Valerio
authors.forename: Umberto Marcello
authors.initials: UM
authors.lastname: Bracale
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Giribono
authors.forename: Emanuela
authors.initials: E
authors.lastname: Viviani
authors.forename: Federica
authors.initials: F
authors.lastname: Caioni
authors.forename: Luca
authors.initials: L
authors.lastname: del Guercio
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007511:Ischemia / Q000139:chemically induced* / Q000188:drug therapy; D007866:Leg / Q000098:blood supply*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000601:surgery; D008654:Mesothelioma / Q000188:drug therapy / Q000601:surgery; D000086002:Mesothelioma, Malignant; D000068437:Pemetrexed / Q000009:adverse effects; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000601:surgery; D015912:Thrombolytic Therapy / Q000379:methods; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D000068437:Pemetrexed; D016190:Carboplatin; D014568:Urokinase-Type Plasminogen Activator