title: Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus.
abstract: Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, cognitive deterioration and urinary incontinence in elderly individuals. These symptoms can be improved by shunt operation in some but not all patients. Therefore, discovering predictive factors for the surgical outcome is of great clinical importance. We used normalized power variance (NPV) of electroencephalography (EEG) waves, a sensitive measure of the instability of cortical electrical activity, and found significantly higher NPV in beta frequency band at the right fronto-temporo-occipital electrodes (Fp2, T4 and O2) in shunt responders compared to non-responders. By utilizing these differences, we were able to correctly identify responders and non-responders to shunt operation with a positive predictive value of 80% and a negative predictive value of 88%. Our findings indicate that NPV can be useful in noninvasively predicting the clinical outcome of shunt operation in patients with iNPH.
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Ishii
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Tamiki
authors.initials: T
authors.lastname: Wada
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Ikeda
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hata
authors.affiliation: UCM-UPM Centre for Biomedical Technology, Department of Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid 28223, Spain.
authors.forename: Leonides
authors.initials: L
authors.lastname: Canuet
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Themistoklis
authors.initials: T
authors.lastname: Katsimichas
authors.affiliation: Brain Functions Laboratory Incorporated, Yokohama 230-0046, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Musha
authors.affiliation: Brain Functions Laboratory Incorporated, Yokohama 230-0046, Japan.
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Matsuzaki
authors.affiliation: Nihon Kohden Corporation, Shinjuku, Tokyo 164-0003, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Imajo
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kanemoto
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nomura
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshiyama
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Iwase
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000368:Aged; D001611:Beta Rhythm / Q000502:physiology; D002557:Cerebrospinal Fluid Shunts; D003071:Cognition / Q000502:physiology; D003710:Demography; D016002:Discriminant Analysis; D004566:Electrodes; D004569:Electroencephalography; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D016896:Treatment Outcome