title: Thiazolidinedione compounds: a patent review (2010 - present).
abstract: BACKGROUND
  The prevalence of metabolic syndrome, obesity and insulin resistance has become an epidemic. Thiazolidinediones (TZDs) affect glucose and lipid metabolism in insulin-sensitive tissues, which in turn reduces the lipid content in the liver by modulating several mediators. TZD as a hypoglycemic agent decrease blood sugar levels. Researchers have also made an attempt to design novel compounds having core structure of TZD with other heterocycles to explore them for anticancer and antimalarial properties. The present review provides an extended study of chemistry and inhibitory activity of established drug candidates containing TZDs, viz. their patenting scenario.
  
  
  METHODS
  In this review, authors have covered TZD-based antidiabetic, anticancer and antimalarial drugs. MEDLINE and PubMed searches, and freedom of information available through FDA, USPTO, EPO and other patent database were used for the preparation of review.
  
  
  CONCLUSIONS
  Diabetes management is very important as the number of diabetic patients increased and therefore the present research article will be very much useful for the development of new molecules.
authors.affiliation: Maharaja Krishnakumarsinhji Bhavnagar University, Department of Chemistry , Bhavnagar 364002 , India dnisheeth@gmail.com.
authors.forename: Nisheeth C
authors.initials: NC
authors.lastname: Desai
authors.forename: Unnat P
authors.initials: UP
authors.lastname: Pandit
authors.forename: Amit
authors.initials: A
authors.lastname: Dodiya
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D010330:Patents as Topic; D045162:Thiazolidinediones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones
keywords: antidiabetic drugs; diabetes; thiazolidinedione; thiazolidinedione-based drugs