title: Propofol and sevoflurane induce distinct burst suppression patterns in rats.
abstract: Burst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ among general anesthetics.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Boston, MA, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Kenny
authors.affiliation: Department of Neurology, Harvard Medical School Boston, MA, USA ; Department of Neurology, Massachusetts General Hospital Boston, MA, USA.
authors.forename: M Brandon
authors.initials: MB
authors.lastname: Westover
authors.affiliation: Department of Electrical and Systems Engineering, Washington University in St. Louis St. Louis, Missouri, USA.
authors.forename: ShiNung
authors.initials: S
authors.lastname: Ching
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Boston, MA, USA ; Department of Anaesthesia, Harvard Medical School Boston, MA, USA ; Institute for Medical Engineering and Science, Massachusetts Institute of Technology Cambridge, MA, USA ; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Cambridge, MA, USA.
authors.forename: Emery N
authors.initials: EN
authors.lastname: Brown
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Boston, MA, USA ; Department of Anaesthesia, Harvard Medical School Boston, MA, USA.
authors.forename: Ken
authors.initials: K
authors.lastname: Solt
keywords: anesthesia; burst suppression; propofol; rodent; sevoflurane