title: Ketoconazole-induced Sweet syndrome: a new association.
abstract: Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis that can be associated with malignancy and medications. A 60-year-old man presented with erythematous, edematous, and ulcerated plaques in the extensor surface of the upper extremities, after a ketoconazole course due to pityrosporum folliculitis. Skin biopsy showed a dense dermal neutrophilic infiltrate, associated with marked papillary dermal edema. Blood count showed leukocytosis and neutrophilia. Skin lesions resolved spontaneously with discoloration after 2 weeks of discontinuation of ketoconazole. Although most cases of drug-induced SS are associated with granulocyte colony-stimulating factor, other medications need to be considered. This is the first reported case of ketoconazole-induced SS despite its widespread use.
authors.affiliation: Departments of *Dermatology and Cutaneous Surgery, and †Pathology, Miller School of Medicine, University of Miami, Miami, FL.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Baquerizo Nole
authors.forename: Eric
authors.initials: E
authors.lastname: Lee
authors.forename: Gabriel
authors.initials: G
authors.lastname: Villada
authors.forename: Paolo
authors.initials: P
authors.lastname: Romanelli
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects*; D001706:Biopsy; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D016463:Sweet Syndrome / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole