title: Contrast dispersion imaging for cancer localization.
abstract: Cancer growth is associated with angiogenic processes in many types of cancer. Several imaging strategies have therefore been developed that target angiogenesis as a marker for cancer localization. To this end, intravascular and extravascular tissue perfusion is typically assessed by dynamic contrast enhanced (DCE) ultrasound (US) and MRI. All the proposed strategies, however, overlook important changes in the microvascular architecture that result from angiogenic processes. To overcome these limitations, we have recently introduced a new imaging strategy that analyzes the intravascular dispersion kinetics of contrast agents spreading through the microvasculature. Contrast dispersion is mainly determined by microvascular multi-path trajectories, reflecting the underlying microvascular architecture. This paper reviews the results obtained for prostate cancer localization by US and MRI dispersion imaging, also presenting the latest new developments and future perspectives.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mischi
authors.forename: Hessel
authors.initials: H
authors.lastname: Wijkstra
mesh_terms: D003287:Contrast Media / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D010743:Phospholipids / Q000493:pharmacokinetics*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012372:ROC Curve; D013459:Sulfur Hexafluoride / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride