title: Nanoparticles in the treatment of mental disorders: a new tool in the psychiatric medication.
abstract: The use of the nanotechnology in the development of new drugs has had in the last years a very widespread presence in the pharmaceutical industry. Diverse diseases that are treated by means of conventional administration systems as capsules, covered tablets or injectable not always have the therapeutic effect expected due to its bioavailability, solubility in aqueous medium and the stability of the excipients that they accompany to the drug. It is for this reason that the formation of nanoparticles either from organic sources as natural polymers like chitosan or synthetic like poly-ε-caprolactone (PCL) affording the inclusion of diverse liposoluble active compounds, they have given excellent results in the incipient treatment of behavior disorders that are necessary drugs that should remain close of active sites at the time. Thus, this review shows the formation of nanoparticles for a direct application of the psychiatric medication, may be considered as a new pharmacological tool by its low cytotoxicity and high efficiency.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sobarzo-Sánchez
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
authors.forename: Eugenio
authors.initials: E
authors.lastname: Uriarte
authors.affiliation: Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Spain. e.sobarzo@usc.es.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Santana
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D011619:Psychotropic Drugs