title: Enhancement of osteogenesis on micro/nano-topographical carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite biocomposite.
abstract: As an FDA-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses excellent mechanical properties similar to those of human cortical bone and is a prime candidate to replace conventional metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. The present work aimed at developing a novel carbon fiber-reinforced polyetheretherketone-nanohydroxyapatite (PEEK/CF/n-HA) ternary biocomposite with micro/nano-topographical surface for the enhancement of the osteogenesis as a potential bioactive material for bone grafting and bone tissue-engineering applications. The combined modification of oxygen plasma and sand-blasting could improve the hydrophily and generate micro/nano-topographical structures on the surface of the CFRPEEK-based ternary biocomposite. The results clearly showcased that the micro-/nano-topographical PEEK/n-HA/CF ternary biocomposite demonstrated the outstanding ability to promote the proliferation and differentiation of MG-63 cells in vitro as well as to boost the osseointegration between implant and bone in vivo, thereby boding well application to bone tissue engineering.
authors.affiliation: College of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147, China.
authors.forename: Anxiu
authors.initials: A
authors.lastname: Xu
authors.affiliation: Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.affiliation: College of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Deng
authors.affiliation: College of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147, China. Electronic address: 18210357357@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: College of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing 401147, China. Electronic address: weishicheng99@163.com.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D001577:Benzophenones; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D015921:Dental Implants; D004285:Dogs; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers; D023822:Tissue Engineering
chemical_list: D001577:Benzophenones; D018786:Bone Substitutes; D015921:Dental Implants; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D002244:Carbon; D017886:Durapatite
keywords: Biocomposite; Carbon fiber-reinforced polyetheretherketone; Micro/nano-topography; Nanohydroxyapatite; Osteogenesis