title: Canine pancreatic-specific lipase concentrations in dogs with heart failure and chronic mitral valvular insufficiency.
abstract: BACKGROUND
  Chronic mitral valvular insufficiency (CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion.
  
  
  OBJECTIVE
  Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations.
  
  
  METHODS
  Sixty-two client-owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age-matched healthy dogs, based on full cardiac exam and routine laboratory tests.
  
  
  METHODS
  Prospective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups.
  
  
  RESULTS
  Serum cPLI concentrations were 54.0 μg/L (IQR: 38.0-78.8 μg/L) in control, 55.0 μg/L (IQR: 38.3-88.8 μg/L) in ISACHC I, 115.0 μg/L (IQR: 45.0-179.0 μg/L) in ISACHC II and 223.0 μg/L (IQR: 119.5-817.5 μg/L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta (LA/Ao) ratio (r = 0.597; P = .000) and the severity of heart failure (r = 0.530; P = .000).
  
  
  CONCLUSIONS
  This study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.
authors.affiliation: Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, South Korea.
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: R
authors.initials: R
authors.lastname: Choi
authors.forename: C
authors.initials: C
authors.lastname: Hyun
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000201:enzymology / Q000209:etiology*; D004285:Dogs; D006333:Heart Failure / Q000150:complications / Q000662:veterinary*; D008049:Lipase / Q000097:blood* / Q000378:metabolism; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000662:veterinary*; D010179:Pancreas / Q000201:enzymology*; D010195:Pancreatitis / Q000201:enzymology / Q000209:etiology / Q000662:veterinary
chemical_list: D008049:Lipase
keywords: Pancreatic lipase immunoreactivity; Pancreatitis; cPLI