title: The influence of body mass index on the accumulation of advanced glycation end products in hemodialysis patients.
abstract: OBJECTIVE
  The level of skin autofluorescence (AF) at a given moment is an independent predictor of mortality in hemodialysis (HD) patients. Skin AF is a measure of the accumulation of advanced glycation end products (AGEs). The aim of the study was to estimate the influence of nutrition on the 1-year increase of skin AF (ΔAF) in HD patients.
  
  
  METHODS
  A total of 156 HD patients were enrolled in this study. Skin AF, body mass index (BMI), superoxide dismutase, myeloperoxidase, C-reactive protein, inter-cellular adhesion molecule-1, von Willebrand factor and heart-type fatty acid-binding protein were measured four times at intervals of approximately half a year. Data from the monthly routine blood analysis were also used. Daily calorie, protein and AGE intakes were assessed from food recordings over a period of 1 week.
  
  
  RESULTS
  A J-shaped relation was found between baseline BMI and ΔAF (P=0.01). The lowest point of the J-shaped curve is found for BMI=24.3 kg/m(2). In the univariate analysis of the contributors to the 1-year ΔAF, we found that beside BMI=24.3 kg/m(2), AGE and calorie intakes, as well as myeloperoxidase and HD vintage, had a P <0.10. The sole independent predictor of the 1-year ΔAF was BMI=24.3 kg/m(2) (P=0.01).
  
  
  CONCLUSIONS
  It appears that calorie, protein and AGE intakes hardly influence the 1-year ΔAF in HD patients. BMI of HD patients of around 24 kg/m(2) resulted in a lower 1-year ΔAF.
authors.affiliation: Department of Nephrology, Clinical Centre, Skopje, Macedonia.
authors.forename: S
authors.initials: S
authors.lastname: Arsov
authors.affiliation: Department of Nephrology, Clinical Centre, Skopje, Macedonia.
authors.forename: L
authors.initials: L
authors.lastname: Trajceska
authors.affiliation: Department of Cardiopulmonary Surgery, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: van Oeveren
authors.affiliation: Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Smit
authors.affiliation: Department of Nephrology, Clinical Centre, Skopje, Macedonia.
authors.forename: P
authors.initials: P
authors.lastname: Dzekova
authors.affiliation: Department of Nephrology, University Hospital, Umeå, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Stegmayr
authors.affiliation: Department of Nephrology, Clinical Centre, Skopje, Macedonia.
authors.forename: A
authors.initials: A
authors.lastname: Sikole
authors.affiliation: Department of Surgery, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Rakhorst
authors.affiliation: Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Graaff
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002149:Energy Intake; D005260:Female; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D009195:Peroxidase / Q000097:blood; D006435:Renal Dialysis; D012867:Skin
chemical_list: D017127:Glycation End Products, Advanced; D009195:Peroxidase