title: The Association between Serum Uric Acid Level and Incidence of Metabolic Syndrome according to Menopausal Status in Korean Women.
abstract: OBJECTIVE
  The aim of this study is to investigate the association between serum uric acid level and metabolic syndrome according to menopausal status in Korean women.
  
  
  METHODS
  A total of 2,241 women who visited to the health promotion center at Pusan National University Hospital from 2010 to 2014 were included in this cross-sectional study. Self-report questionnaires and interviews with healthcare providers were used to assess disease history, medication history, menstrual history and body size measuring. Anthropometric measurements and laboratory results were compared as presence of metabolic syndrome and menopausal status by student-t test. Logistic regression analysis was performed between presence of metabolic syndrome and presumable predictive factors, such as age, menopause and serum uric acid.
  
  
  RESULTS
  The prevalence rate of metabolic syndrome were 7.45% (63/846) in pre-menopausal group and 23.87% (333/1395) in menopausal group. Serum uric acid level was higher in menopausal women than premenopausal women (4.6 ± 1.1 vs. 4.3 ± 0.9. P = 0.000). And, its concentration was also higher in metabolic syndrome than normal women regarding of menopausal statue (premenopause 4.7 ± 1.1 vs. 4.2 ± 0.8, P = 0.001, menopause 4.9 ± 1.3 vs. 4.5 ± 1.0, P = 0.000). Multiple logistic regression analysis showed serum uric acid and age have relationship with metabolic syndrome (OR: 1.453, 95% confidence interval [CI]: 1.074-1.111, P = 0.000; OR: 1.092, 95% CI: 1.305-1.619, P = 0.000).
  
  
  CONCLUSIONS
  We could find out some potential of uric acid as predictive factor for metabolic syndrome in premenopausal and menopausal group. Further investigation is required to clarify the relationship between serum uric acid, menopause and metabolic syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Jong Kil
authors.initials: JK
authors.lastname: Joo
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Gil Pyo
authors.initials: GP
authors.lastname: Hong
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Si Eun
authors.initials: SE
authors.lastname: Han
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Seung Chul
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Samsung Changwon Hospital, Changwon, Korea.
authors.forename: Chang Woon
authors.initials: CW
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Busan, Korea.
authors.forename: Kyu Sup
authors.initials: KS
authors.lastname: Lee
keywords: Menopause; Metabolic syndrome X; Uric acid