title: The effect of maternal sleep-disordered breathing on the infant's neurodevelopment.
abstract: OBJECTIVE
  We sought to examine the effect of maternal sleep-disordered breathing (SDB) on infant general movements (GMs) and neurodevelopment.
  
  
  METHODS
  Pregnant women with uncomplicated full-term pregnancies and their offspring were prospectively recruited from a community and hospital low-risk obstetric surveillance. All participants completed a sleep questionnaire on second trimester and underwent ambulatory sleep evaluation (WatchPAT; Itamar Medical, Caesarea, Israel). They were categorized as SDB (apnea hypopnea index>5) and controls. Infant GMs were assessed in the first 48 hours and at 8-11 and 14-16 weeks of age. At 12 months of age the Infant Developmental Inventory and the Brief Infant Sleep Questionnaire were administered.
  
  
  RESULTS
  In all, 74 women and their full-term infants were studied. Eighteen (24%) women had SDB. Mean birthweight was 3347.1±423.9 g. Median Apgar score at 5 minutes was 10 (range, 8-10). In adjusted comparisons, no differences were found between infants born to mothers with SDB and controls in GM scores in all 3 evaluations. Low social developmental score was detected at 12 months in 64% of infants born to SDB mothers compared to 25% of infants born to controls (adjusted P=.036; odds ratio, 16.7). Infant snoring was reported by 41.7% of mothers with SDB compared to 7.5% of controls (P=.004).
  
  
  CONCLUSIONS
  Our preliminary results suggest that maternal SDB during pregnancy has no adverse effect on neonatal and infant neuromotor development but may affect social development at 1 year.
authors.affiliation: Sleep Disorders Center, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: tauman@tlvmc.gov.il.
authors.forename: Riva
authors.initials: R
authors.lastname: Tauman
authors.affiliation: Department of Physical Therapy, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Luba
authors.initials: L
authors.lastname: Zuk
authors.affiliation: Child Neurology and Developmental Unit, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shimrit
authors.initials: S
authors.lastname: Uliel-Sibony
authors.affiliation: Department of Obstetrics and Gynecology, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Jessica
authors.initials: J
authors.lastname: Ascher-Landsberg
authors.affiliation: Sleep Disorders Center, Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Katsav
authors.affiliation: Sleep Disorders Center, Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Mira
authors.initials: M
authors.lastname: Farber
authors.affiliation: Sleep Disorders Center, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Sivan
authors.affiliation: Child Neurology and Developmental Unit, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Haim
authors.initials: H
authors.lastname: Bassan
mesh_terms: D000328:Adult; D001034:Apgar Score; D002657:Child Development; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007804:Language Development; D008297:Male; D009048:Motor Skills; D017286:Polysomnography; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D012913:Snoring / Q000453:epidemiology; D012919:Social Behavior; D011795:Surveys and Questionnaires
keywords: fetal outcome; neurodevelopment; pregnancy; sleep-disordered breathing