title: Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.
abstract: Cytidine (C) to Uridine (U) RNA editing is a post-trancriptional modification that until recently was known to only affect Apolipoprotein b (Apob) RNA and minimally require 2 components of the C to U editosome, the deaminase APOBEC1 and the RNA-binding protein A1CF. Our latest work has identified a novel RNA-binding protein, RBM47, as a core component of the editosome, which can substitute A1CF for the editing of ApoB mRNA. In addition, new RNA species that are subjected to C to U editing have been identified. Here, we highlight these recent discoveries and discuss how they change our view of the composition of the C to U editing machinery and expand our knowledge of the functional attributes of C to U RNA editing.
authors.affiliation: a Embryology Unit; Children's Medical Research Institute ; Westmead , Australia.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fossat
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam
mesh_terms: D000071479:APOBEC-1 Deaminase; D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism*; D003562:Cytidine / Q000378:metabolism*; D003564:Cytidine Deaminase / Q000378:metabolism*; D006801:Humans; D017393:RNA Editing; D012333:RNA, Messenger / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism*
chemical_list: D001055:Apolipoproteins B; D012333:RNA, Messenger; D003562:Cytidine; D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; D003564:Cytidine Deaminase; D014529:Uridine
keywords: A1CF; APOBEC1; Apolipoprotein b; Intestine; RBM47; RNA editing