title: A novel one-dimensional manganese(II) coordination polymer containing both dicyanamide and pyrazinamide ligands: synthesis, spectroscopic investigations, X-ray studies and evaluation of biological activities.
abstract: A novel 1D coordination polymer {[Mn(μ1,5-dca)2(PZA)2](PZA)2}n, 1, has been synthesized and characterized by single crystal X-ray crystallography. The coordination mode of dicyanamide (dca) and pyrazinamide (PZA) ligands was inferred by IR spectroscopy. The compound 1 was evaluated for in vitro antimycobacterial and antitumor activities. It demonstrated better in vitro activity against Mycobacterium tuberculosis than pyrazinamide and its MIC value was determined. Complex 1 was also screened for its in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines. In addition, the antibacterial activity of complex 1 has been tested against Gram(+) and Gram(-) bacteria and it has shown promising broad range anti-bacterial activity.
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Tabrizi
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: Chinif@cc.iut.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Chiniforoshan
authors.affiliation: School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland.
authors.forename: Patrick
authors.initials: P
authors.lastname: McArdle
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents / Q000494:pharmacology; D002234:Carbodiimides / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D008024:Ligands; D008345:Manganese / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011718:Pyrazinamide / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002234:Carbodiimides; D056831:Coordination Complexes; D008024:Ligands; D011108:Polymers; D011718:Pyrazinamide; D008345:Manganese
keywords: Antibacterial activity; Antitumor activity; Dicyanamide; Manganese(II); Pyrazinamide