title: On-off closed-loop control of vagus nerve stimulation for the adaptation of heart rate.
abstract: Vagus nerve stimulation (VNS) is a potential therapeutic approach in a number of clinical applications. Although VNS is commonly delivered in an open-loop approach, it is now recognized that closed-loop approaches may be necessary to optimize the therapy and minimize side effects of neuro-stimulation devices. In this paper, we describe a prototype system for real-time control of the instantaneous heart rate, working synchronously with the heart period. As a first step, an on-off control method has been integrated. The system is evaluated on one sheep with induced heart failure, showing the interest of the proposed approach.
authors.forename: Hector Romero
authors.initials: HR
authors.lastname: Ugalde
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: Alain
authors.initials: A
authors.lastname: Bel
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bonnet
authors.forename: David
authors.initials: D
authors.lastname: Andreu
authors.forename: Philippe
authors.initials: P
authors.lastname: Mabo
authors.forename: Guy
authors.initials: G
authors.lastname: Carrault
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
mesh_terms: D000222:Adaptation, Physiological; D000465:Algorithms; D000818:Animals; D004560:Electricity; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology*; D012756:Sheep; D014630:Vagus Nerve / Q000502:physiology*; D055536:Vagus Nerve Stimulation / Q000379:methods*