title: Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment.
abstract: OBJECTIVE
  To address the possible role of brain regional metabolic differences between different types of mild cognitive impairment (MCI).
  
  
  METHODS
  Brain regional metabolites in patients with amnestic mild cognitive impairment (A-MCI) and vascular mild cognitive impairment (V-MCI) were measured via proton magnetic resonance spectroscopy (1H MRS) technique. Twenty-eight patients with A-MCI, 24 patients with V-MCI and 34 normal controls (NC) were tested by a battery of neuropsychological screens. All the subjects underwent the single voxel 1H MRS with the regions of interest (ROIs) located in the left frontal lobe, left basal ganglia and left hippocampus.
  
  
  RESULTS
  The A-MCI showed lower NAA/Cr ratio in the left hippocampus. There was a significant correlation between recent memory score and the NAA/Cr ratio. In V-MCI, NAA/Cr ratio in the left frontal lobe was positively correlated with the cognitive score evaluated with Cambridge Cognitive Examination-Chinese version (CAMCOG-C) and its subscores of orientation, praxi, language and language comprehension.
  
  
  CONCLUSIONS
  This study indicated that there are differences in metabolism related to brain regions between A-MCI and V-MCI, thus it may be concluded that 1H MRS may be a useful tool to differentiate A-MCI and V-MCI.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Neurology, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Magnetic Resonance Room, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Emergency, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Magnetic Resonance Room, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Haibao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Magnetic Resonance Room, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Fujun
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China. Electronic address: sunzhwu@hotmail.com.
authors.forename: Zhongwu
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D000647:Amnesia / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D015140:Dementia, Vascular / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods
keywords: Alzheimer's disease; Mild cognitive impairment; Proton magnetic resonance spectroscopy; Vascular dementia