title: Detection of a transient R292K mutation in influenza A/H3N2 viruses shed for several weeks by an immunocompromised patient.
abstract: We describe the case of an immunocompromised patient, positive for influenza A virus (H3N2), in whom the neuraminidase R292K mutation was transiently detected during oseltamivir treatment. The R292K mutation was identified by direct testing in 3 of 11 respiratory specimens collected throughout the patient's illness but in none of the cultures from those specimens.
authors.affiliation: Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA babadyn@mskcc.org.
authors.forename: N Esther
authors.identifier: http://orcid.org/0000-0003-4399-1249
authors.initials: NE
authors.lastname: Babady
authors.affiliation: Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Laplante
authors.affiliation: Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Yi-Wei
authors.identifier: http://orcid.org/0000-0003-4888-6771
authors.initials: YW
authors.lastname: Tang
authors.affiliation: Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
authors.forename: Kirsten
authors.initials: K
authors.lastname: St George
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D015967:Gene Expression Regulation, Viral; D006801:Humans; D016867:Immunocompromised Host; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics*; D053139:Oseltamivir / Q000627:therapeutic use; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D017201:Virus Shedding
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase