title: Ethanol induces the formation of water-permeable defects in model bilayers of skin lipids.
abstract: We show that ethanol can induce the formation of water-permeable defects in model membranes of skin, providing a fresh perspective on ethanol as a membrane modulator. We rationalise our findings in terms of the chemical nature of ethanol, i.e., a combination of its hydrogen bonding propensity and amphiphilic character.
authors.affiliation: Department of Chemistry and Centre for Scientific Computing, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. r.notman@warwick.ac.uk.
authors.forename: R
authors.initials: R
authors.lastname: Thind
authors.forename: D W
authors.initials: DW
authors.lastname: O'Neill
authors.forename: A
authors.initials: A
authors.lastname: Del Regno
authors.forename: R
authors.initials: R
authors.lastname: Notman
mesh_terms: D000431:Ethanol / Q000737:chemistry*; D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D012867:Skin / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D014867:Water; D000431:Ethanol