title: Fatty acid metabolism in the regulation of T cell function.
abstract: The specific regulation of cellular metabolic processes is of major importance for directing immune cell differentiation and function. We review recent evidence indicating that changes in basic cellular lipid metabolism have critical effects on T cell proliferation and cell fate decisions. While induction of de novo fatty acid (FA) synthesis is essential for activation-induced proliferation and differentiation of effector T cells, FA catabolism via β-oxidation is important for the development of CD8(+) T cell memory as well as for the differentiation of CD4(+) regulatory T cells. We consider the influence of lipid metabolism and metabolic intermediates on the regulation of signaling and transcriptional pathways via post-translational modifications, and discuss how an improved understanding of FA metabolism may reveal strategies for manipulating immune responses towards therapeutic outcomes.
authors.affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Electronic address: Lochner.Matthias@mh-hannover.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Lochner
authors.affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
authors.forename: Luciana
authors.initials: L
authors.lastname: Berod
authors.affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Electronic address: sparwasser.tim@mh-hannover.de.
authors.forename: Tim
authors.initials: T
authors.lastname: Sparwasser
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D007156:Immunologic Memory; D056747:Immunomodulation; D008055:Lipids / Q000096:biosynthesis; D008213:Lymphocyte Activation; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D051779:Sterol Regulatory Element Binding Proteins / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D008055:Lipids; D051779:Sterol Regulatory Element Binding Proteins; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases
keywords: ACC; AMPK; T cells; fatty acid oxidation; fatty acid synthesis; fatty acids; mTOR