title: Factor XIII B subunit polymorphisms and the risk of coronary artery disease.
abstract: The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. mezeiza@med.unideb.hu.
authors.forename: Zoltán A
authors.initials: ZA
authors.lastname: Mezei
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. zsbereczky@med.unideb.hu.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Bereczky
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. ekatona@med.unideb.hu.
authors.forename: Éva
authors.initials: É
authors.lastname: Katona
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. rekagin@gmail.com.
authors.forename: Réka
authors.initials: R
authors.lastname: Gindele
authors.affiliation: Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. baloghemiliadr@gmail.com.
authors.forename: Emília
authors.initials: E
authors.lastname: Balogh
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. fiatal.szilvia@sph.unideb.hu.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Fiatal
authors.affiliation: Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. laszlobalogh76@gmail.com.
authors.forename: László
authors.initials: L
authors.lastname: Balogh
authors.affiliation: Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. iczuriga@dote.hu.
authors.forename: István
authors.initials: I
authors.lastname: Czuriga
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. adanz.roza@sph.unideb.hu.
authors.forename: Róza
authors.initials: R
authors.lastname: Ádány
authors.affiliation: Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. edesi@dote.hu.
authors.forename: István
authors.initials: I
authors.lastname: Édes
authors.affiliation: Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary. muszbek@med.unideb.hu.
authors.forename: László
authors.initials: L
authors.lastname: Muszbek
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005176:Factor XIII / Q000032:analysis / Q000235:genetics*; D026122:Factor XIIIa / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D005340:Fibrinogen; D005176:Factor XIII; C054380:factor XIIIb; D026122:Factor XIIIa