title: The topographical arrangement of cutoff spatial frequencies across lower and upper visual fields in mouse V1.
abstract: The visual response to spatial frequency (SF), a characteristic of spatial structure across position in space, is of particular importance for animal survival. A natural challenge for rodents is to detect predators as early as possible while foraging. Whether neurons in mouse primary visual cortex (V1) are functionally organized to meet this challenge remains unclear. Combining intrinsic signal optical imaging and single-unit recording, we found that the cutoff SF was much greater for neurons whose receptive fields were located above the mouse. Specifically, we discovered that the cutoff SF increased in a gradient that was positively correlated with the elevation in the visual field. This organization was present at eye opening and persisted through adulthood. Dark rearing delayed the maturation of the cutoff SF globally, but had little impact on the topographical organization of the cutoff SF, suggesting that this regional distribution is innately determined. This form of cortical organization of different SFs may benefit the mouse for detection of airborne threats in the natural environment.
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: An
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Hanxiao
authors.initials: H
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Cai
authors.affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Intramural Research Programme, National Institute on Drug Abuse, National Institutes of Health, Baltimore MD 21224.
authors.forename: Da-Ting
authors.initials: DT
authors.lastname: Lin
authors.affiliation: CAS Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P.R. China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D003624:Darkness; D008810:Mice, Inbred C57BL; D010775:Photic Stimulation; D013997:Time Factors; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*