title: Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense.
abstract: Five selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) competitive inhibitors, hupehenols A-E (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols A-E (1-5) showed inhibition against human 11β-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11β-HSD1 when compared to murine 11β-HSD1.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204, Yunnan, People's Republic of China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Shao
authors.forename: Mahesh
authors.initials: M
authors.lastname: Pal
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Kou
authors.initials: K
authors.lastname: Wang
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027925:Viburnum / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D014315:Triterpenes; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1