title: Importance of genetics in acute myeloid leukemia.
abstract: Acute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML, most patients will die from relapsed disease. Whole-genome studies have identified novel recurrent gene mutations with prognostic impact in AML; furthermore, it is likely that in the near future genome-wide sequencing will become a routine for newly diagnosed patients with AML. Therefore, future clinical trials should aim to identify genetically defined high-risk patients, and further research is necessary to identify effective agents and develop new individualized therapeutic strategies for the treatment of this deadly disease.
authors.forename: R
authors.initials: R
authors.lastname: Pippa
authors.affiliation: Department of Biochemistry and Genetics and CIMA, University of Navarra, Pamplona, 31008, Spain. modero@unav.es.
authors.forename: M D
authors.initials: MD
authors.lastname: Odero
mesh_terms: D005544:Forecasting; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D011379:Prognosis