title: Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide-lipid complexes.
abstract: We demonstrate that recent observed increases in cell permeation activity of cyclic peptides via transporter sequences is due to the underlying phase behavior of peptide-lipid complexes and its relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences.
authors.affiliation: Department of Bioengineering, University of California- Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Bioengineering, University of California- Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA.
authors.forename: Uh-Joo
authors.initials: UJ
authors.lastname: Choe
authors.affiliation: Department of Bioengineering, University of California- Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Kamei
authors.affiliation: Department of Bioengineering, University of California- Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA ; California NanoSystems Institute, University of California- Los Angeles.
authors.forename: Gerard C L
authors.initials: GC
authors.lastname: Wong