title: [Ameliorated effects of cyclovirobuxine D on oxidative stress and energy metabolism in experimental cardiac injured rats induced by sympathetic overactivity in vivo].
abstract: OBJECTIVE
  To investigate the ameliorated effect of CVB-D on oxidative stress and energy metabolism in experimental cardiac injuried rats induced by sympathetic overactivity in vivo.
  
  
  METHODS
  SD rats were randomly divided into five groups as following: control group, model group, Vitamin E 150 mg/kg group, CVB-D low dose and high dose groups, respectively. The rat experimental cardiac injury model was established by exposed to norepinephrine (NE) 3 mg/kg by ip for 16 d. The drugs were administrated to rat for 16 d by ig. The body weight of rats were monitored during all of the experimental period. At the designing ending-time point the indexes were assayed as following: cardiac index, hydroxyproline, histopathologically examination, oxidative stress ( MDA, SOD, CAT, GSH-Px and T-AOC) and energy metabolism indicatricle ( Na+, K(+) -ATPase, and Ca2+, Mg(2+) -ATPase).
  
  
  RESULTS
  After exposed with NE for 16 d, the rats of model group was appeared dysfunction of oxidative stress and energy metabolism such as decreasing body weight, increasing cardiac index and hydroxyproline in cardiac tissue, decreasing Na+, K(+) -ATPase and Ca(2+), Mg(2+) -ATPase activities, and deteriorating the oxidative stress. Treated with CVB-D could ameliorate all of the exacerbated indexes.
  
  
  CONCLUSIONS
  CVB-D has protective effect against oxidative stress and energy metabolism in rats of experimental myocardial injury induced by sympathetic overactivity.
authors.affiliation: Research Division of Pharmacology, Guiyang, China.
authors.forename: Yi-Ni
authors.initials: YN
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Bo
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Liu
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Shen
mesh_terms: D000251:Adenosine Triphosphatases; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology*; D006335:Heart Injuries; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E
chemical_list: D004365:Drugs, Chinese Herbal; D014810:Vitamin E; C032939:cyclovirobuxine D; D000251:Adenosine Triphosphatases