title: Capillary blood flow imaging within human finger cuticle using optical microangiography.
abstract: We report non-invasive 3D imaging of capillary blood flow within human finger cuticle by the use of Doppler optical microangiography (DOMAG) and ultra-high sensitive optical microangiography (UHS-OMAG) techniques. Wide velocity range DOMAG method is applied to provide red blood cell (RBC) axial velocity mapping in capillary loops with ranges of ±0.9 mm/s and ±0.3 mm/s. Additionally, UHS-OMAG technique is engineered to acquire high resolution image of capillary morphology. The presented results are promising to facilitate clinical trials of treatment and diagnosis of various diseases such as diabetes, Raynaud's phenomenon, and connective tissue diseases by quantifying cutaneous blood flow changes within human finger cuticle.
authors.affiliation: Department of Electrical Engineering, University of Washington, Seattle, WA, USA.
authors.forename: Utku
authors.initials: U
authors.lastname: Baran
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000792:Angiography / Q000379:methods*; D002196:Capillaries / Q000000981:diagnostic imaging* / Q000502:physiology*; D005385:Fingers / Q000033:anatomy & histology* / Q000098:blood supply*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008833:Microcirculation; D012867:Skin / Q000098:blood supply*
keywords: Doppler optical microangiography; capillary blood flow; optical coherence tomography; skin microcirculation; ultra-high sensitive optical microangiography