title: Melatonin and female hormone secretion in postmenopausal overweight women.
abstract: Estrogen deficiency is considered to be the main cause of increased appetite and increased weight in postmenopausal women. In this period, reduced secretion of melatonin (MEL) was also observed. The aim of the study was to evaluate the secretion of melatonin, 17-β estradiol and follicle-stimulating hormone (FSH) in relation to body mass index (BMI) in pre- and postmenopausal women. The study included 90 women divided into three equal groups: group I (control)-women without menstrual disorders, group II-postmenopausal women without change in appetite and body weight, group III-postmenopausal women experiencing increased appetite and weight gain. In each patient, serum melatonin, 17-β-estradiol, FSH and urine a 6-sulfatoxymelatonin (aMT6s) were determined. Compared to the control group, the level of melatonin and estradiol was statistically lower. The FSH level was higher than in the groups of postmenopausal women. No significant correlation was found in all groups between the level of melatonin and the levels of estradiol and FSH. A negative correlation was found between aMT6s excretion and BMI, and a positive correlation between the level of FSH and BMI, mainly in overweight women. The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders.
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. ewa.walecka-kapica@umed.lodz.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Walecka-Kapica
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. jan.chojnacki@umed.lodz.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Chojnacki
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. agnieszka.stepien@umed.lodz.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stępień
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. wachowskapatrycja@gmail.com.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Wachowska-Kelly
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. grazyna.klupinska@umed.lodz.pl.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Klupińska
authors.affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland. cezary.chojnacki@umed.lodz.pl.
authors.forename: Cezary
authors.initials: C
authors.lastname: Chojnacki
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000652:urine*; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives / Q000097:blood* / Q000652:urine; D008875:Middle Aged; D050177:Overweight; D017698:Postmenopause
chemical_list: C054513:6-sulfatoxymelatonin; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D008550:Melatonin