title: Long-term survival following pancreatectomy and s-1 chemotherapy for pancreatic acinar cell carcinoma with peritoneal dissemination: a case report and literature review.
abstract: Current case is the third report of S-1 chemotherapy against acinar cell carcinoma (ACC) of pancreas, and our patient has achieved the longest reported recurrence-free survival, longer than 6 years, despite the presence of disseminated nodules at laparotomy.A 77-year-old man presented with abdominal discomfort. Computed tomography showed a low-density tumor in the pancreas tail and the patient was referred for surgery. A 3-cm sized pancreatic tumor, with localized disseminated nodules, was detected on laparotomy. Distal pancreatectomy with concomitant resection of disseminated nodules was performed, and histopathological examination revealed an ACC. Oral S-1 chemotherapy was administered postsurgery, and the patient showed no sign of recurrence during 73 months of follow-up. This is the first report of long-term survivor of pancreatic ACC with peritoneal dissemination, following pancreatectomy and S-1 chemotherapy.Current case suggests a beneficial effect of S-1 chemotherapy in cases of ACC.
authors.affiliation: From the Department of Gastroenterological Surgery (TS, YS, TO, AK, YS, TT, TN); Department of Diagnostic Pathology (JI); and Department of Radiology (SM), Kochi Health Sciences Center, Kochi, Japan.
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shima
authors.forename: Takehiro
authors.initials: T
authors.lastname: Okabayashi
authors.forename: Akihito
authors.initials: A
authors.lastname: Kozuki
authors.forename: Jun
authors.initials: J
authors.lastname: Iwata
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Saisaka
authors.forename: Teppei
authors.initials: T
authors.lastname: Tokumaru
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakamura
authors.forename: Sojiro
authors.initials: S
authors.lastname: Morita
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D018267:Carcinoma, Acinar Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010537:Peritoneum / Q000473:pathology; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid