title: Printable and transparent micro-electrocorticography (μECoG) for optogenetic applications.
abstract: Micro-electrocorticography (μECoG) displays advantages over traditional invasive methods. The μECoG electrode can record neural activity with high spatial-temporal resolution and it can reduce implantation side effects (e.g. vascular and local-neuronal damage, tissue encapsulation, infection). In this study, we propose a printable transparent μECoG electrode for optogenetic applications by using ultrasonic microfluid printing technique. The device is based on poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT: PSS) as a conductive polymer, polydimethylsiloxane (PDMS) as an insulating polymer and poly(chloro-para-xylylene) (Parylene-C) as the device substrate. We focus on ultrasonic microfluid printing due to its low production cost, excellent material handling capability, and its customizable film thickness (down to 5-20 microns). The ultrasonic fluid-printed μECoG displays high spatial resolution and records simulated signal (0-200 Hz sine wave) effectively with low electrode impedance (50-200 kOhms@1kHz). The μECoG also shows good biocompatibility suitable for customizable chronic implants. This new neural interfacing device could be combined with optogenetics and Brain-Computer Interface (BCI) applications for a possible future use in neurological disease diagnosis and rehabilitations.
authors.forename: Thaninamon
authors.initials: T
authors.lastname: Kimtan
authors.forename: Jiyaporn
authors.initials: J
authors.lastname: Thupmongkol
authors.forename: Justin C
authors.initials: JC
authors.lastname: Williams
authors.forename: Sanitta
authors.initials: S
authors.lastname: Thongpang
mesh_terms: D000069280:Electrocorticography / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D062308:Optogenetics / Q000295:instrumentation*; D011327:Printing