title: [The differences between three distinct locations of colorectal cancers based on clinicopathological characteristics and molecular features].
abstract: OBJECTIVE
  To investigate the differences of clinical characteristics and molecular features among colorectal cancer subsides and provide evidence for colorectal cancer protection, diagnosis and treatment.
  
  
  METHODS
  All of 4 316 colorectal patients from Shanghai cancer center were selected for clinical character analysis, among which, 2 224 subjects for molecular feature analysis. Clinic pathological characteristics like age, gender, tumor types, histological types, differentiation and T-stage, as well as molecular features like hMLH1, hMSH2, CD44, p21, p53, COX2,E-cadherin, Her2 and Ki-67, were involved into this research.
  
  
  RESULTS
  It showed that compared with left-sided colon and rectal cancers, right-sided cancers occurred more in women (46.0% (541/1 176); 39.2% (424/1 083); 41.2% (848/2 057), respectively, χ² = 11.85, P < 0.01), had more mucinous or signet-ring carcinoma (12.0% (128/1 064), 5.8% (56/960), 4.0% (75/1 859), respectively, χ² = 31.27, P < 0.01), poor differentiated carcinoma (32.1% (343/1 069), 19.5% (201/1 033), 19.3% (380/1 967), respectively, χ² = 72.66, P < 0.01) , and advanced T stage (87.9% (992/1 129), 83.2% (869/1 045), 72.2% (1 486/2 057), respectively, χ² = 121.44, P < 0.01). Meanwhile, the rates of hMLH1 were higher in right-sided colon cancers when compared with rectal cancers (13.4% (59/439) vs 8.5% (88/1 035), OR (95%CI): 1.67 (1.18-2.37)), as well as the rates of hMSH2 negative expression (4.9% (22/452) vs 2.4% (26/1 083), OR (95% CI): 2.08(1.17-3.71)). The rates of p53 positive expression were higher in right-sided colon cancers when compared with rectal cancers (76.2% (321/421) vs 68.4%, (776/1 134), OR (95% CI): 0.68 (0.52-0.87)). Compared with right-sided colon cancers, the rates of Her2 positive expression were higher in rectal cancers (19.3% (176/913) vs 13.2% (45/340), OR (95% CI): 1.57 (1.10-2.23)) , as well as the rates of Ki-67 expression which was positive in more than 50% cells (73.6% (840/1 141) vs 65.6% (299/456), OR (95% CI): 0.68 (0.54-0.86)).
  
  
  CONCLUSIONS
  There are specific characteristics in right-sided colon cancers. The difference of molecular features between right-sided colon and rectal cancers are more significant.
authors.affiliation: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center (Department of Oncology, Shanghai Medical College, Fudan University), Shanghai 200032, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhao
authors.forename: Sanjun
authors.initials: S
authors.lastname: Cai
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Email: liufq021@163.com.
authors.forename: Fangqi
authors.initials: F
authors.lastname: Liu
mesh_terms: D002288:Adenocarcinoma, Mucinous; D015820:Cadherins; D002277:Carcinoma; D018279:Carcinoma, Signet Ring Cell; D002681:China; D003110:Colonic Neoplasms; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012004:Rectal Neoplasms; D012737:Sex Factors
chemical_list: D015820:Cadherins