title: Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation.
abstract: Polymeric micelles are nanostructures formed by the self-aggregation of copolymeric amphiphiles above the critical micellar concentration. Due to the flexibility to tailor different molecular features, they have been exploited to encapsulate motley poorly-water soluble therapeutic agents. Moreover, the possibility to combine different amphiphiles in one single aggregate and produce mixed micelles that capitalize on the features of the different components substantially expands the therapeutic potential of these nanocarriers. Despite their proven versatility, polymeric micelles remain elusive to the market and only a few products are currently undergoing advanced clinical trials or reached clinical application, all of them for the therapy of different types of cancer and administration by the intravenous route. At the same time, they emerge as a nanotechnology platform with great potential for non-parenteral mucosal administration. However, for this, the interaction of polymeric micelles with mucus needs to be strengthened. The present review describes the different attempts to develop mucoadhesive polymeric micelles and discusses the challenges faced in the near future for a successful bench-to-bedside translation.
authors.affiliation: Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: alesosnik@gmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sosnik
authors.affiliation: Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Menaker Raskin
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D008823:Micelles; D009092:Mucous Membrane; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends
chemical_list: D000180:Acrylic Resins; D008823:Micelles; D011108:Polymers; D011109:Polymethacrylic Acids; D011134:Polysaccharides; C006903:carbopol 940; D048271:Chitosan
keywords: Clinical translation; Modified polymeric amphiphiles; Mucoadhesion; Mucoadhesive polymeric micelles; Non-parenteral drug delivery; Polysaccharide-graft copolymers