title: [Intracranial hemorrhage in three haemophilic adults: A severe complication of hemophilia].
abstract: BACKGROUND
  Intracranial hemorrhage (ICH) complications are uncommon at hemophilic patients.
  
  
  METHODS
  We report three cases of ICH occurring in hemophilic patients. Contributing factors were identified in two patients: hemophilia severity, presence of inhibitor, hepatitis C virus infection, and high blood pressure. No contributing factor was identified in the last patient.
  
  
  CONCLUSIONS
  Rapid diagnosis of ICH is crucial in hemophilic patients. A search for contributing factors, both those specific to hemophilia, and those favoring ICH in the general population, is essential to optimize therapeutic care. Specific substitutive treatment for the deficient factor is a difficult management challenge.
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France; Unité neuro-vasculaire, université Bordeaux Segalen, CHU de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France. Electronic address: sharmilas@hotmail.fr.
authors.forename: S
authors.initials: S
authors.lastname: Sagnier
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France; Unité neuro-vasculaire, université Bordeaux Segalen, CHU de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Thomas
authors.affiliation: Unité neuro-vasculaire, université Bordeaux Segalen, CHU de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France; Service de pédiatrie, CHU de Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux cedex, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Huguenin
authors.affiliation: Hématologie biologique, centre régional de traitement de l'hémophilie, CHU de Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Castet
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Poli
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France.
authors.forename: S
authors.initials: S
authors.lastname: Debruxelles
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Renou
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Rouanet
authors.affiliation: Unité neuro-vasculaire, pôle de neurosciences cliniques, hôpital Pellegrin, université Bordeaux Segalen, CHU de Bordeaux, place Amélie Raba-Léon, 33000 Bordeaux, France; Unité neuro-vasculaire, université Bordeaux Segalen, CHU de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux, France.
authors.forename: I
authors.initials: I
authors.lastname: Sibon
mesh_terms: D000328:Adult; D005164:Factor IX / Q000032:analysis; D015942:Factor VIIa / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013788:Thalamus / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D005164:Factor IX; D015942:Factor VIIa
keywords: Contributing factors; Facteurs favorisant; Hemophilia; Hémophilie; Hémorragie intracérébrale; Intracranial hemorrhage; Prise en charge thérapeutique; Therapeutic care