title: Interleukin-8: A critical chemokine in biliary atresia.
abstract: Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin-8 (IL-8) is an important mediator of inflammation and the immune response in human disease. IL-8 is overexpressed in BA, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL-8 in BA.
authors.affiliation: Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China; Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Dong
authors.forename: Shan
authors.initials: S
authors.lastname: Zheng
mesh_terms: D001656:Biliary Atresia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology; D016209:Interleukin-8 / Q000276:immunology*; D008103:Liver Cirrhosis; D058990:Molecular Targeted Therapy
chemical_list: D015415:Biomarkers; C508606:CXCL8 protein, human; D018836:Inflammation Mediators; D016209:Interleukin-8
keywords: biliary atresia; inflammation; interleukin-8; liver fibrosis; signaling