title: MSX2 in ameloblast cell fate and activity.
abstract: While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expression regulation and thus the control of enamel quality. Some of these factors, such as MSX2, are mainly confined to the dental epithelium. MSX2 homeoprotein controls several stages of the ameloblast life cycle. This chapter introduces MSX2 and its target genes in the ameloblast and provides an overview of knowledge regarding its effects in vivo in transgenic mouse models. Currently available in vitro data on the role of MSX2 as a transcription factor and its links to other players in ameloblast gene regulation are considered. MSX2 modulations are relevant to the interplay between developmental, hormonal and environmental pathways and in vivo investigations, notably in the rodent incisor, have provided insight into dental physiology. Indeed, in vivo models are particularly promising for investigating enamel formation and MSX2 function in ameloblast cell fate. MSX2 may be central to the temporal-spatial restriction of enamel protein production by the dental epithelium and thus regulation of enamel quality (thickness and mineralization level) under physiological and pathological conditions. Studies on MSX2 show that amelogenesis is not an isolated process but is part of the more general physiology of coordinated dental-bone complex growth.
authors.affiliation: Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, UMRS 1138 Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Descartes Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Diderot Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Babajko
authors.affiliation: Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, UMRS 1138 Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Descartes Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Diderot Paris, France ; Centre de Référence des Maladies Rares de la Face et de la Cavité Buccale MAFACE, Hôpital Rothschild Paris, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: de La Dure-Molla
authors.affiliation: Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, UMRS 1138 Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Descartes Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Diderot Paris, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Jedeon
authors.affiliation: Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, UMRS 1138 Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Descartes Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris Paris, France ; Laboratory of Molecular Oral Pathophysiology, Centre de Recherche des Cordeliers, Université Paris-Diderot Paris, France ; Centre de Référence des Maladies Rares de la Face et de la Cavité Buccale MAFACE, Hôpital Rothschild Paris, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Berdal
keywords: MSX2; ameloblast; differentiation; enamel; teeth; transcription factors