title: Therapeutic effects of resveratrol in a mouse model of HDM-induced allergic asthma.
abstract: Asthma is an inflammatory disease of the lungs characterized by airway remolding. In this study, we examined whether resveratrol exerts protective effects on allergic asthma in a murine model. To investigate the effects of resveratrol on allergic airway inflammation in house dust mite (HDM)-induced mouse asthma and explore its mechanism, a chronic asthma mouse model was established by intranasally administering extracts of HDM (25μg of protein in 10μl of saline) for 5days/week for up to 7 consecutive weeks. Resveratrol (50mg/kg body weight), dexamethasone (1mg/kg body weight) or a vehicle was administered orally 1h before antigen challenges for up to 2weeks. Compared with the HDM-induced mice, the level of TNF-α of the BALF in the resveratrol+HDM-treated mice had obviously decreased. Histological examination of the lung tissue revealed that the resveratrol treatments attenuated the fibrotic response and airway inflammation. In addition, resveratrol inhibited the expression of the Syk protein and degranulation in mast cells. The presented findings collectively suggest that resveratrol has a therapeutic effect on mouse allergic asthma, and its mechanism of action might be related to reducing the production of the Syk protein.
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Jiaxiang
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Life Science, Nankai University, Tianjin 300071, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Baoping
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China.
authors.forename: Jiari
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, ChangZhi Maternal & Child Health Care Hospital, ChangZhi 046001, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Bai
authors.affiliation: Medical Experiment Education Department, Medical College of Nanchang University, Nanchang 330031, China. Electronic address: sirlrp@163.com.
authors.forename: Renping
authors.initials: R
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D039741:Antigens, Dermatophagoides / Q000276:immunology; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D015550:Cell Degranulation / Q000187:drug effects; D002460:Cell Line; D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D039981:Pyroglyphidae / Q000276:immunology; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000009:adverse effects; D000072377:Syk Kinase; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D039741:Antigens, Dermatophagoides; D047908:Intracellular Signaling Peptides and Proteins; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D000077185:Resveratrol
keywords: Airway inflammation; Allergic asthma; Resveratrol; Syk