title: Optimal management of breast cancer in the elderly patient: current perspectives.
abstract: Breast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.
authors.affiliation: Medical Oncology Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Le Saux
authors.affiliation: Gynaecology-Obstetrics Department, University Hospital, Saint-Etienne, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Ripamonti
authors.affiliation: Croix Rousse University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France ; Lyon University, Lyon, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Bruyas
authors.affiliation: Lyon University, Lyon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Bonin
authors.affiliation: Medical Oncology Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France ; Lyon University, Lyon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Freyer
authors.affiliation: Lyon University, Lyon, France ; Geriatric Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Bonnefoy
authors.affiliation: Lyon University, Lyon, France ; Geriatric Unit, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Falandry
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D019468:Disease Management; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging
keywords: breast cancer; chemotherapy; elderly; geriatric assessment; radiotherapy; surgery