title: Minerals salt composition and secondary metabolites of Euphorbia hirta Linn., an antihyperglycemic plant.
abstract: Phytochemical study and research on acute toxicity were performed on the aerial parts (leaves and stems) of Euphorbia hirta Linn. The phytochemical screening and chromatography revealed the presence of saponin, sterol, terpene, alkaloids, polyphenols, tannins and flavonoids and especially mucilage. The evaluation of total polyphenols and total flavonoids gave 120.97 ± 7.07 gallic acid equivalents (GAE) mg/g (mg of GAE/g of extract) of dry extract and 41.4 ± 0.5 mg quercetin equivalent per gram (QE/g) (mg of QE/g of plant extract) of dry extract respectively. The physicochemical study revealed moisture content of 7.73% ± 0.00%, total ash 7.48% ± 0.03%. Sulfuric ash 9.05% ± 0.01%, hydrochloric acid insoluble ash of 0.8% ± 0.02%. The search for minerals salt revealed the presence of Cr, Zn, K, Ca and Mg having an important role in glucose metabolism. The acute toxicity study showed that the toxic dose may be above 3000 mg/kg. The results of these studies indicate that extracts from the leaves and stem of E. hirta Linn. contains trace elements and minerals salt and bioactive secondary metabolites which explain their therapeutic uses for treating diabetes mellitus.
authors.affiliation: Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët Boigny Cocody-Abidjan, 22 BP 747 Abidjan 22, Côte d'Ivoire.
authors.forename: N'Guessan Bra
authors.initials: NB
authors.lastname: Yvette Fofie
authors.affiliation: Department of Traditional Medicine, Faculty of Pharmaceutical Sciences University of Bamako Mali ; Faculty of Pharmaceutical Sciences of Bamako, Bamako, Mali.
authors.forename: Rokia
authors.initials: R
authors.lastname: Sanogo
authors.affiliation: Faculty of Biological Sciences, University of Péléforo Gon Coulibaly, BP 1328 Korhogo.
authors.forename: Kiyinlma
authors.initials: K
authors.lastname: Coulibaly
authors.affiliation: Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët Boigny Cocody-Abidjan, 22 BP 747 Abidjan 22, Côte d'Ivoire.
authors.forename: Diénéba
authors.initials: D
authors.lastname: Kone-Bamba
keywords: Euphorbia hirta Linn; mineral salt; phytochemical; trace elements