title: Cycloolivil, a lignan from the roots of Stereospermum suaveolens.
abstract: BACKGROUND
  Stereospermum suaveolens DC. (Syn. S. chelonoides) belonging to family Bignoniaceae is an important medicinal plant in India. Traditionally, it is mainly used as analgesic, liver stimulant, astringent, wound healing and antidyspeptic. Roots of this plant are one of the ingredients of Dashamularishta. The plant has been studied for many pharmacological actions, only few were concerned with isolation of active compounds.
  
  
  OBJECTIVE
  The present work deals with the isolation and identification of phytochemical constituents present in the roots of Stereospermum suaveolens.
  
  
  METHODS
  The compounds were isolated from the ethyl acetate-soluble fraction from the methanol extract of S. suaveolens by using open silica gel column chromatography and HPLC was carried out for all the fractions to target the major peaks in fractions.
  
  
  CONCLUSIONS
  The isolated compounds structures were elucidated by analysis of spectroscopic data (UV, IR, 1D-NMR, and MS) and characterized as Cycloolivil (1) reported for the first time from this plant species, Lapachol (2) and β-sitosterol (3), respectively.
authors.affiliation: Pharmacognosy, Government College of Pharmacy, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: B Abdul
authors.initials: BA
authors.lastname: Wahab Sab
authors.affiliation: Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: Janani
authors.initials: J
authors.lastname: Jacob
authors.affiliation: Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: Gururaja Giligar
authors.initials: GG
authors.lastname: Manjunath
authors.affiliation: Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: Vineet Kumar
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Mundkinajeedu
authors.affiliation: Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.
authors.forename: Shashidhara
authors.initials: S
authors.lastname: Shankarappa
keywords: Cycloolivil; isolation; lapachol; stereospermum suaveolens; β-sitosterol