title: Micromotors to capture and destroy anthrax simulant spores.
abstract: Towards addressing the need for detecting and eliminating biothreats, we describe a micromotor-based approach for screening, capturing, isolating and destroying anthrax simulant spores in a simple and rapid manner with minimal sample processing. The B. globilli antibody-functionalized micromotors can recognize, capture and transport B. globigii spores in environmental matrices, while showing non-interactions with excess of non-target bacteria. Efficient destruction of the anthrax simulant spores is demonstrated via the micromotor-induced mixing of a mild oxidizing solution. The new micromotor-based approach paves a way to dynamic multifunctional systems that rapidly recognize, isolate, capture and destroy biological threats.
authors.affiliation: Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA. josephwang@eng.ucsd.edu.
authors.forename: Jahir
authors.initials: J
authors.lastname: Orozco
authors.forename: Guoqing
authors.initials: G
authors.lastname: Pan
authors.forename: Sirilak
authors.initials: S
authors.lastname: Sattayasamitsathit
authors.forename: Michael
authors.initials: M
authors.lastname: Galarnyk
authors.forename: Joseph
authors.initials: J
authors.lastname: Wang
mesh_terms: D000881:Anthrax / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control*; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D001407:Bacillus / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D015374:Biosensing Techniques / Q000295:instrumentation*; D023482:Bioterrorism; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D013171:Spores, Bacterial / Q000187:drug effects* / Q000302:isolation & purification*
chemical_list: D000906:Antibodies