title: Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells.
abstract: Chronic inflammation has been linked to cancer development and metastasis. We have recently demonstrated that γδ T cells are the major cellular source of IL-17 (γδT17) and accumulation of γδT17 cells correlates with human colorectal cancer progression through recruitment and expansion of myeloid-derived suppressor cells, thus converting tumor-elicited inflammation into immunosuppression.
authors.affiliation: Department of Medicine; Tumor Immunobiology Program ; James Graham Brown Cancer Center; University of Louisville School of Medicine ; Louisville, KY USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.affiliation: Cancer Institute; Department of Oncology ; The Second Affiliated Hospital; Zhejiang University School of Medicine ; Hangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
keywords: APC, antigen-presenting cell; CRC, colorectal cancer; DAMP, danger-associated molecular pattern; DC, dendritic cell; GM-CSF; IL-17; KO, knock out; MDSC, myeloid-derived suppressor cell; MMP, matrix metalloproteinase; PGE2, prostaglandin E2; PMN, polymorphonuclear; VEGF, vascular endothelial growth factor; granulocyte-macrophage colony-stimulating factor; inflammation; myeloid-derived suppressor cells; tumor progression; γδ T cells