title: In vitro susceptibility testing of eravacycline is unaffected by medium age and nonstandard assay parameters.
abstract: Eravacycline is a fluorocycline antibiotic in phase 3 clinical development for complicated intra-abdominal and urinary tract infections. To support its clinical development, a study was conducted to evaluate the effects of various susceptibility test parameters on the MIC values for aerobic bacteria. The results showed that eravacycline appears to be largely unaffected by medium age, medium additives, and other nonstandard assay conditions.
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA tgrossman@tphase.com.
authors.forename: Trudy H
authors.initials: TH
authors.lastname: Grossman
authors.affiliation: Eurofins Medinet, Chantilly, Virginia, USA.
authors.forename: Chris M
authors.initials: CM
authors.lastname: Pillar
authors.affiliation: Eurofins Medinet, Chantilly, Virginia, USA.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Sahm
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA.
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Sutcliffe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D013754:Tetracyclines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D013754:Tetracyclines; C571179:eravacycline