title: Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic.
abstract: Arsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.
authors.affiliation: University of Arizona, College of Medicine, Department of Pediatrics, Tucson, Arizona, USA.|University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Kurzius-Spencer
authors.affiliation: University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.|University of Arizona, Arizona Cancer Center, Tucson, Arizona, USA.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Harris
authors.affiliation: University of Arizona, Arizona Cancer Center, Tucson, Arizona, USA.
authors.forename: Vern
authors.initials: V
authors.lastname: Hartz
authors.affiliation: Carolinas Healthcare System, Dickson Advanced Analytics Group, Charlotte, North Carolina, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Roberge
authors.affiliation: University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.|University of Arizona, Arizona Cancer Center, Tucson, Arizona, USA.
authors.forename: Chiu-Hsieh
authors.initials: CH
authors.lastname: Hsu
authors.affiliation: University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: O'Rourke
authors.affiliation: University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
authors.forename: Jefferey L
authors.initials: JL
authors.lastname: Burgess
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona; D001151:Arsenic / Q000008:administration & dosage / Q000097:blood*; D015415:Biomarkers; D003430:Cross-Sectional Studies; D004032:Diet; D004326:Drinking; D060766:Drinking Water / Q000737:chemistry*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D011939:Mental Recall; D008875:Middle Aged; D012044:Regression Analysis; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D014874:Water Pollutants, Chemical; D020780:Matrix Metalloproteinase 9; D001151:Arsenic