title: Effects of intravenous indomethacin on reduction of symptomatic patent ductus arteriosus cases and decreasing the need for prolonged mechanical ventilation.
abstract: BACKGROUND
  We decided to investigate the effects of injecting Indomethacin on reducing complications of Patent Ductus Arteriosus (PDA) and the need for prolonged mechanical ventilation.
  
  
  METHODS
  During this randomized clinical trial, 70 premature infants with matched gestational age and birth weight were divided into case and control groups. In the study group, intravenous indomethacin started from the first 2-12 hours of birth. All patients were followed by echocardiography at the fourth day and skull ultrasound in the second week.
  
  
  RESULTS
  Symptomatic PDA rate was significantly higher in the control group (25.7% vs. 0%; P≤0.001). Incidence of grade 1-3 intraventricular hemorrhage was higher in the control group and the ratio of needed time for respiratory support in the control group to the case group was approximately 2.1.
  
  
  CONCLUSIONS
  Intravenous Indomethacin reduced the number of PDA cases and incidence of grade 2 and 3 intraventricular hemorrhage, without any short term side effects.
authors.affiliation: Children Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abdollah
authors.initials: A
authors.lastname: Jannatdoust
authors.affiliation: Children Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Samadi
authors.affiliation: Children Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saadollah
authors.initials: S
authors.lastname: Yeganehdoust
authors.affiliation: Children Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Heydarzadeh
authors.affiliation: Children Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Alikhah
authors.affiliation: Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran ; Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Piri
authors.affiliation: Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran ; Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi-Behzad
keywords: Hemorrhage; Indomethacin; Mechanical Ventilation; Patent Ductus Arteriosus