title: Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats.
abstract: The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.
authors.affiliation: Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Tubarao, SC, Brazil, fabriciapetronilho@yahoo.com.br.
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Drielly
authors.initials: D
authors.lastname: Florentino
authors.forename: Fernanda
authors.initials: F
authors.lastname: Silvestre
authors.forename: Lucineia Gainski
authors.initials: LG
authors.lastname: Danielski
authors.forename: Diego Zapelini
authors.initials: DZ
authors.lastname: Nascimento
authors.forename: Andriele
authors.initials: A
authors.lastname: Vieira
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Kanis
authors.forename: Jucelia Jeremias
authors.initials: JJ
authors.lastname: Fortunato
authors.forename: Marwa
authors.initials: M
authors.lastname: Badawy
authors.forename: Tatiana
authors.initials: T
authors.lastname: Barichello
authors.forename: Joao
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use*; D002351:Carrageenan / Q000633:toxicity*; D004195:Disease Models, Animal; D054833:Isoindoles; D055370:Lung Injury / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D016566:Organoselenium Compounds / Q000627:therapeutic use*; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D002351:Carrageenan