title: Bio-enhanced repair of the anterior cruciate ligament.
abstract: Suture repair of the anterior cruciate ligament (ACL) has been widely abandoned in favor of ACL reconstruction, largely because of the high rates of failure and unreliability of the outcomes after suture repair. However, there have been recent basic science studies that suggest that combining a suture repair with a biological adjunct may improve the results of suture repair of the ACL, with several studies in large animal models showing equivalent strength of an ACL treated with bio-enhanced repaired to that of an ACL graft at 3, 6, and 12 months after surgery. In addition, the groups treated with bio-enhanced repair had significantly less osteoarthritis when compared with the animals undergoing ACL reconstruction. These findings have led to a renewed interest in bio-enhanced primary repair as a way to make repair of the ACL a viable option for a select group of patients in the future.
authors.affiliation: Sports Medicine Research Laboratory, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Benedikt L
authors.initials: BL
authors.lastname: Proffen
authors.affiliation: Sports Medicine Research Laboratory, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Jakob T
authors.initials: JT
authors.lastname: Sieker
authors.affiliation: Sports Medicine Research Laboratory, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.. Electronic address: martha.murray@childrens.harvard.edu.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Murray
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000502:physiology / Q000601:surgery*; D003094:Collagen / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D012038:Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D003094:Collagen