title: Acquired factor VIII inhibitor syndrome: A rare cause of hematuria.
abstract: A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia). With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.
authors.affiliation: Department of Urology, SRM Medical College, Kattankulathur, Tamil Nadu, India.
authors.forename: Muthuvel Seral
authors.initials: MS
authors.lastname: Kannan
authors.affiliation: Department of Urology, SRM Medical College, Kattankulathur, Tamil Nadu, India.
authors.forename: Thallur Ramakrishnan
authors.initials: TR
authors.lastname: Raj Kumar
authors.affiliation: Department of Urology, SRM Medical College, Kattankulathur, Tamil Nadu, India.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Subramanian
keywords: Acquired factor VIII inhibitor; acquired hemophilia; hematuria