title: Gold nanoparticles coated zinc oxide nanorods as the matrix for enhanced L-lactate sensing.
abstract: In this study, an enzymatic electrochemical biosensor for L-lactate detection was proposed. The device was developed based on gold nanoparticles (Au NPs) modified zinc oxide nanorods (ZnO NRs). The sensing performance of the device was examined by cyclic voltammetry and amperometry. Compared with pristine ZnO based biosensor, Au/ZnO based sensor exhibited higher sensitivity of 24.56 μA cm(-2) mM(-1), smaller K(M)(app) of 1.58 mM, lower detection limit of 6 μM and wider linear range of 10 μM-0.6 mM for L-lactate detection. The introduction of Au NPs enhances electro-catalytic ability and electron migration, which contributes to the improvement of the sensing performance. Hence, the results confirm the essential character of Au NPs in such semiconductor based electrochemical biosensing system.
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Fang
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Yousong
authors.initials: Y
authors.lastname: Gu
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China. Electronic address: xqyan@mater.ustb.edu.cn.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Yan
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Kang
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Lin
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China.
authors.forename: Leichao
authors.initials: L
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People's Republic of China; Key Laboratory of New Energy Materials and Technologies, University of Science and Technology Beijing, Beijing 100083, People's Republic of China. Electronic address: yuezhang@ustb.edu.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D006046:Gold / Q000737:chemistry*; D019344:Lactic Acid / Q000032:analysis*; D053768:Metal Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D019344:Lactic Acid; D006046:Gold; D015034:Zinc Oxide
keywords: Electrochemical biosensor; Gold nanoparticles; Lactate oxidase; Zinc oxide; l-Lactate