title: Multidrug resistance-reversal effects of resin glycosides from Dichondra repens.
abstract: Investigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A-C (1-3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25μM increased the cytotoxicity of vincristine by 1.03-1.78-fold.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Wei-Bin
authors.initials: WB
authors.lastname: Song
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Wen-Qiong
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. Electronic address: ljxuan@mail.shcnc.ac.cn.
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D002240:Carbohydrate Sequence; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D008969:Molecular Sequence Data; D018515:Plant Leaves / Q000737:chemistry; D006109:Poaceae / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry* / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
chemical_list: D006027:Glycosides; D012116:Resins, Plant; D014750:Vincristine
keywords: Dichondra repens; Multidrug-resistance (MDR) reversal activity; Resin glycoside acids