title: Synthesis of novel azole-fused quinazolines via one-pot, sequential Ullmann-type coupling and intramolecular dehydrogenative C-N bonding.
abstract: An efficient one-pot sequential procedure is described for the synthesis of novel azole-fused quinazolines through Pd/Cu co-catalyzed, Ullmann-type coupling followed by cross dehydrogenative coupling of various azoles such as 1H-imidazole, 1H-benzimidazole and 1H-1,2,4-triazole with 2-(2-bromophenyl)-1H-imidazole/benzimidazoles. The developed strategy has offered good yields (52-81%) of diverse N-fused tetra-, penta- and hexa-cyclic frameworks in a single step.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani 333031, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Nitesh Kumar
authors.initials: NK
authors.lastname: Nandwana
authors.forename: Kasiviswanadharaju
authors.initials: K
authors.lastname: Pericherla
authors.forename: Pinku
authors.initials: P
authors.lastname: Kaswan
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011799:Quinazolines / Q000737:chemistry
chemical_list: D001393:Azoles; D011799:Quinazolines; D010165:Palladium; D002244:Carbon; D003300:Copper; D009584:Nitrogen; D002118:Calcium