title: Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy.
abstract: Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.
authors.affiliation: Laboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, CP 14269, Tlalpan, DF, Mexico.
authors.forename: Marisela
authors.initials: M
authors.lastname: Méndez-Armenta
authors.affiliation: Laboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, CP 14269, Tlalpan, DF, Mexico.
authors.forename: Concepción
authors.initials: C
authors.lastname: Nava-Ruíz
authors.affiliation: Laboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, CP 14269, Tlalpan, DF, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Juárez-Rebollar
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Avenida Universidad 3000, CP 04510, Coyoacán, DF, Mexico.
authors.forename: Erika
authors.initials: E
authors.lastname: Rodríguez-Martínez
authors.affiliation: Departamento de Genética, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, CP 14269, La Fama, Tlalpan, DF, Mexico.
authors.forename: Petra Yescas
authors.initials: PY
authors.lastname: Gómez
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species