title: Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO.
abstract: The synthesis of 2-substituted indoles and benzofurans was achieved by nucleophilic aromatic substitution, followed by subsequent 5-endo-dig cyclization between the nucleophile and an ortho acetylene. The acetylene serves the dual role of the electron withdrawing group to activate the substrate for SNAr, and the C1-C2 carbon scaffold for the newly formed 5-membered heteroaromatic ring. This method allows for the bond forming sequence of Ar-X-N/O-C1 to proceed in a single synthetic step, furnishing indoles and benzofurans in moderate to high yields. Since the method is not transition metal mediated, brominated and chlorinated substrates are tolerated, and benzofuran formation can be conducted using water or water-DMSO mixtures as solvent.
authors.affiliation: Department of Chemistry, Colby College, 5754 Mayflower Hill Drive, Waterville, Maine 04901, USA. jlkatz@colby.edu.
authors.forename: R
authors.initials: R
authors.lastname: Hudson
authors.forename: N P
authors.initials: NP
authors.lastname: Bizier
authors.forename: K N
authors.initials: KN
authors.lastname: Esdale
authors.forename: J L
authors.initials: JL
authors.lastname: Katz
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014867:Water / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D006571:Heterocyclic Compounds; D007211:Indoles; D014867:Water; D000114:Acetylene; D004121:Dimethyl Sulfoxide