title: Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients.
abstract: BACKGROUND
  Inflammation is one of the main contributory factors to the etiopathogenesis of multiple sclerosis (MS). Dietary interventions with Lipia citriadora (lemon verbena) extracts have been proved to be effective in the prevention of inflammatory diseases.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the effect of lemon verbena supplementation in pro- and anti- inflammatory serum biomarkers of patients with different clinical subtypes of multiple sclerosis.
  
  
  METHODS
  The effect of lemon verbena supplementation (10% w/w verbascoside) was evaluated in a randomized, double-blinded placebo-controlled study with 30 participants classified in relapsing-remitting (n=10), primary progressive (n=5) and secondary progressive (n=15) MS presentations. Serum cytokine and C reactive protein levels were assessed in intervention and control groups for each MS clinical subtype after 28 days of dietary supplementation.
  
  
  RESULTS
  Serum levels of C reactive protein and 8 cytokines/ inflammatory (IFN-γ, IL-12, IL-23, IL-6, TNF-α, TGF-β, IL-4 and IL-10) markers were studied. Secondary progressive MS- supplemented patients showed C reactive protein concentrations significantly lower compared to the placebo group (p.
authors.affiliation: Institute of Food Science and Technology (ICTAL), University of León. State Reference Centre (CRE) of Disability and Dependency, San Andrés del Rabanedo, León.. elba.mauriz@unileon.es.
authors.forename: Elba
authors.initials: E
authors.lastname: Mauriz
authors.affiliation: Institute of Biomedicine (IBIOMED), University of León.. elba.mauriz@unileon.es.
authors.forename: Daniela
authors.initials: D
authors.lastname: Vallejo
authors.affiliation: Institute of Biomedicine (IBIOMED), University of León.. elba.mauriz@unileon.es.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Tuñón
authors.affiliation: Campofrio Food Group, Madrid. Spain.. elba.mauriz@unileon.es.
authors.forename: Jesús María
authors.initials: JM
authors.lastname: Rodriguez-López
authors.affiliation: Campofrio Food Group, Madrid. Spain.. elba.mauriz@unileon.es.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Pérez
authors.affiliation: Institute of Food Science and Technology (ICTAL), University of León.. elba.mauriz@unileon.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz-Gómez
authors.affiliation: Institute of Food Science and Technology (ICTAL), University of León.. elba.mauriz@unileon.es.
authors.forename: María del Camino
authors.initials: Mdel C
authors.lastname: García-Fernández
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D010936:Plant Extracts / Q000494:pharmacology*; D032412:Verbena / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; D016207:Cytokines; D010936:Plant Extracts