title: ABCB1 C3435T and CYP2C19*2 polymorphisms in a Palestinian and Turkish population: A pharmacogenetic perspective to clopidogrel.
abstract: Clopidogrel is an antiplatelet drug used to prevent recurrent ischemic events after acute coronary syndrome and/or coronary stent implantation. Single nucleotide polymorphisms (SNPs) such as CYP2C19*2 and ABCB1 C3435T have been found to play a role in different individual responses to clopidogrel. Since the prevalence of these SNPs is generally known to differ from one population to another, the aim of this study was to examine their prevalence in both a Palestinian and Turkish population. One hundred unrelated Palestinian subjects and 100 unrelated Turkish subjects were analyzed for CYP2C19*2 and ABCB1 C3435T polymorphisms by the amplification refractory mutation system (ARMS). Results showed an ABCB1 3435 T allele frequency of 0.46 (95% CI 0.391 to 0.529) in the Palestinian sample and 0.535 (95% CI 0.4664 to 0.6036) in the Turkish sample. CYP2C19*2 allele frequency was 0.095 (95% CI 0.0558 to 0.134) in the Palestinian sample and 0.135 (95% CI 0.088 to 0.182) in the Turkish sample. Our results provide information about the prevalence of the polymorphisms related to clopidogrel response in both the Palestinian and Turkish populations, in order to improve the safety and efficacy of clopidogrel through use of genetically guided, individualized treatment. The prevalence of these clinically significant alleles shed light on the importance of testing them before prescribing clopidogrel.
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: Suheir
authors.initials: S
authors.lastname: Nassar
authors.affiliation: Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Mount of Olives, East Jerusalem, West Bank.
authors.forename: Omar
authors.initials: O
authors.lastname: Amro
authors.affiliation: Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Mount of Olives, East Jerusalem, West Bank.
authors.forename: Hilal
authors.initials: H
authors.lastname: Abu-Rmaileh
authors.affiliation: Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Mount of Olives, East Jerusalem, West Bank.
authors.forename: Inji
authors.initials: I
authors.lastname: Alshaer
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: May
authors.initials: M
authors.lastname: Korachi
authors.affiliation: Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Mount of Olives, East Jerusalem, West Bank.
authors.forename: Suhail
authors.initials: S
authors.lastname: Ayesh
keywords: ABCB1; CYP2C19; Clopidogrel; Palestinian; SNP; Turkish