title: Calcium hydroxylapatite: over a decade of clinical experience.
abstract: BACKGROUND
  Calcium hydroxylapatite is one of the most well-studied dermal fillers worldwide and has been extensively used for the correction of moderate-to-severe facial lines and folds and to replenish lost volume.
  
  
  OBJECTIVE
  To mark the milestone of 10 years of use in the aesthetic field, this review will consider the evolution of calcium hydroxylapatite in aesthetic medicine, provide a detailed injection protocol for a global facial approach, and examine how the unique properties of calcium hydroxylapatite provide it with an important place in today's market.
  
  
  METHODS
  This article is an up-to-date review of calcium hydroxylapatite in aesthetic medicine along with procedures for its use, including a detailed injection protocol for a global facial approach by three expert injectors.
  
  
  CONCLUSIONS
  Calcium hydroxylapatite is a very effective agent for many areas of facial soft tissue augmentation and is associated with a high and well-established safety profile. Calcium hydroxylapatite combines high elasticity and viscosity with an ability to induce long-term collagen formation making it an ideal agent for a global facial approach.
authors.affiliation: Doctors Inc., Amsterdam, The Netherlands;
authors.forename: Jani Van
authors.initials: JV
authors.lastname: Loghem
authors.affiliation: Pacific State Medical University of Health Ministry of Russia, Vladivostok, Russia;
authors.forename: Yana Alexandrovna
authors.initials: YA
authors.lastname: Yutskovskaya
authors.affiliation: University of Washington School of Medicine, Seattle, Washington.
authors.forename: Wm
authors.initials: W
authors.lastname: Philip Werschler