title: Efficacy and safety of switching to insulin glulisine from other rapid-acting insulin analogs in children with type 1 diabetes.
abstract: We investigated the efficacy and safety of switching to insulin glulisine (GLU) from other rapid-acting insulin analogs (Ra) in children with type 1 diabetes treated with multiple daily injections of insulin or continuous subcutaneous insulin infusion. A total of 26 children with type 1 diabetes were included. Ra in all of these patients was changed to GLU, and they were observed for a 6-month period after having previously finished treatment with other Ra. The mean glycated hemoglobin value decreased from 7.6 ± 1.0 to 7.4 ± 0.9% (P = 0.0034), and mean plasma glucose values after breakfast and supper also improved from 183 ± 50 to 153 ± 32 mg/dL (P = 0.0035), and from 203 ± 29 to 164 ± 23 mg/dL (P < 0.0001), respectively. Furthermore, the mean frequency of hypoglycemia was reduced from 7 ± 6 to 4 ± 4/month (P = 0.0004), while insulin doses and obesity degree were stable with statistically non-significant differences. In conclusion, switching to GLU might be a good treatment option for improving glycemic control in children with type 1 diabetes.
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Urakami
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Remi
authors.initials: R
authors.lastname: Kuwabara
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Habu
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Misako
authors.initials: M
authors.lastname: Okuno
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine Tokyo, Japan.
authors.forename: Shori
authors.initials: S
authors.lastname: Takahashi
keywords: Children; Glulisine; Type 1 diabetes