title: Heritability of pain catastrophizing and associations with experimental pain outcomes: a twin study.
abstract: This study used a twin paradigm to examine genetic and environmental contributions to pain catastrophizing and the observed association between pain catastrophizing and cold-pressor task (CPT) outcomes. Male and female monozygotic (n = 206) and dizygotic twins (n = 194) from the University of Washington Twin Registry completed a measure of pain catastrophizing and performed a CPT challenge. As expected, pain catastrophizing emerged as a significant predictor of several CPT outcomes, including cold-pressor Immersion Tolerance, Pain Tolerance, and Delayed Pain Rating. The heritability estimate for pain catastrophizing was found to be 37% with the remaining 63% of variance attributable to unique environmental influence. Additionally, the observed associations between pain catastrophizing and CPT outcomes were not found attributable to shared genetics or environmental exposure, which suggests a direct relationship between catastrophizing and experimental pain outcomes. This study is the first to examine the heritability of pain catastrophizing and potential processes by which pain catastrophizing is related to experimental pain response.
authors.affiliation: Department of Psychology, University of North Texas, Denton, TX, USA Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA Department of Psychology, McGill University, Montreal, QC, Canada Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium Department of Epidemiology, University of Washington, Seattle, WA, USA VA Center of Excellence for Stress and Mental Health and Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.
authors.forename: Zina
authors.initials: Z
authors.lastname: Trost
authors.forename: Eric
authors.initials: E
authors.lastname: Strachan
authors.forename: Michael
authors.initials: M
authors.lastname: Sullivan
authors.forename: Tine
authors.initials: T
authors.lastname: Vervoort
authors.forename: Ally R
authors.initials: AR
authors.lastname: Avery
authors.forename: Niloofar
authors.initials: N
authors.lastname: Afari
mesh_terms: D000293:Adolescent; D000328:Adult; D058443:Catastrophization / Q000209:etiology* / Q000235:genetics*; D003080:Cold Temperature / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000150:complications / Q000235:genetics / Q000523:psychology; D010147:Pain Measurement; D017288:Pain Threshold; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014427:Twins / Q000235:genetics; D055815:Young Adult; D015053:Zygote