title: Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.
abstract: To investigate the significance between the expression of P27, Fragile Histidine Triad (FHIT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), and P73 in esophageal squamous cell carcinoma (ESCC), paraffin-embedded tissue blocks of 200 cases were obtained from the Fourth Hospital of Hebei Medical University. The sections were used for (HE) and immunohistochemical staining streptavidin-perosidase (SP). The immunologic reagents used included antibodies against P27, FHIT, PTEN, and P73. From I- to II- and III-graded ESCC, the positive expression of P27 was decreased, but the P73 was increased, showing a ladded change (P < .05). The oncogene and tumor suppressor gene protein expression were related to the differentiation and can be one of the factors of influencing prognosis. The oncogene and tumor suppressor gene protein expression was related to the prognostic factor, and thus, it is valuable for clinical treatment and judging prognosis to detect the expression of P27, FHIT, PTEN, and P73 in ESCC.
authors.affiliation: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China.
authors.forename: Yanning
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China. Electronic address: mali1021@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Pathology, Institute of the Fourth Hospital of Hebei Medical University, No. 12, Jiankangt Road, Shijiazhuang, 050011, PR China. Electronic address: annama@163.com.
authors.forename: Yueping
authors.initials: Y
authors.lastname: Liu
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis* / Q000235:genetics; D016612:Paraffin Embedding; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis* / Q000235:genetics; D016707:Tissue Fixation; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D051059:PTEN Phosphohydrolase; D018809:Proliferating Cell Nuclear Antigen; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; D000099170:Bis(5'-adenosyl)triphosphatase; C000606460:TP73 protein, human; C413374:p27 antigen; C494929:PTEN protein, human
keywords: Esophageal squamous carcinoma; FHIT; P27; P73; PTEN