title: Diagnosis, classification and treatment of gestational trophoblastic neoplasia.
abstract: Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.
authors.affiliation: Masters Degree Program in Maternal and Child Health, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
authors.forename: Andressa
authors.initials: A
authors.lastname: Biscaro
authors.affiliation: Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
authors.forename: Antônio
authors.initials: A
authors.lastname: Braga
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
authors.forename: Ross Stuart
authors.initials: RS
authors.lastname: Berkowitz
mesh_terms: D005260:Female; D031901:Gestational Trophoblastic Disease / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D011247:Pregnancy