title: Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury.
abstract: In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huo
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Jiachuan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Jinbiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China.
authors.forename: Shaonian
authors.initials: S
authors.lastname: Xu
keywords: adrenocorticotropic hormone; aquaporin 4; blast-induced injury; craniocerebral injury; hyperbaric oxygen; pituitary gland