title: [Expression of CD55 and CD59 in chronic rhinosinusitis and its significance].
abstract: OBJECTIVE
  To understand the expression of complement regulatory proteins CD55 and CD59, which secreted by epithelial cells of normal and chronic sinusitis patients.
  
  
  METHODS
  Cell culture and flow cytometry were used to detect the expression of complement regulatory proteins CD55 and CD59.SPSS 18.0 software was used to analyze the data.
  
  
  RESULTS
  CD55 was expressed both in normal nasal mucosa and mucosa of chronic sinusitis. The expression in normal group was 0.001 ± 0.001, significantly lower than that in CRS group which was 0.067 ± 0.028 (t = -10.535, P < 0.01). CD59 was also expressed in the two groups . In normal group, the expression of CD59 was 0.879 ± 0.005, significantly higher than that in CRS group which was 0.238 ± 0.034 (t = 83.416, P < 0.01).
  
  
  CONCLUSIONS
  The nasal mucosa in CRS patients showed low expression of CD55 and high expression of CD59. This mechanism may be involved in the occurrence of CRS.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xia
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China. Email: wyinfeng@126.com.
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
mesh_terms: D018958:CD55 Antigens / Q000378:metabolism*; D018957:CD59 Antigens / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D012220:Rhinitis / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism*
chemical_list: D018958:CD55 Antigens; D018957:CD59 Antigens