title: Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery.
abstract: OBJECTIVE
  The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery.
  
  
  METHODS
  After approval by our institutional Ethics Committee, 40 patients were recruited and randomized into two drug groups: esmolol (Group E) and nitroglycerine (Group N). In group E, a bolus dose of 500 μg/kg esmolol was administered over 30 sec followed by continuous administration at a dose of 25-300 μg/ kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 μg/kg/min.
  
  
  RESULTS
  During the hypotensive period, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p<0.001, p<0.001, p<0.001, p<0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p<0.001, p<0.001, p<0.001, p<0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p<0.001). Systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045).
  
  
  CONCLUSIONS
  Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Guney
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Fatma Nur
authors.initials: FN
authors.lastname: Kaya
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Yavascaoglu
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Alp
authors.initials: A
authors.lastname: Gurbet
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Nazan Has
authors.initials: NH
authors.lastname: Selmi
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Sener
authors.initials: S
authors.lastname: Kaya
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Kutlay
keywords: Anesthesia; Controlled hypotension; Esmolol hydrochloride; Nitroglycerin