title: Synthesis and characterization of antibacterial carboxymethylcellulose/CuO bio-nanocomposite hydrogels.
abstract: In this study, carboxymethyl cellulose/CuO nanocomposite hydrogels have been synthesized through the in situ formation of CuO nanoparticles within swollen carboxymethyl cellulose hydrogels. The aim of the study was to investigate whether these hydrogels have the potential to be used in antibacterial applications. The formation of CuO nanoparticles in the hydrogels was confirmed using X-ray diffraction and scanning electron microscopy studies. In addition, swelling behavior of nanocomposite hydrogels was investigated in various pH values and salt solutions. Furthermore, the CuO nanocomposite hydrogels were tested for antibacterial activities. The antibacterial activity of the nanocomposite hydrogels was studied by inhibition zone method against Escherichia coli and Staphylococcus aureus. The nanocomposite hydrogels demonstrated excellent antibacterial effects. Therefore, the developed carboxymethyl cellulose/CuO nanocomposite hydrogels can be used effectively for biomedical application.
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Gholamali
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
authors.affiliation: Departments of Microbiology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aghazadeh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D012965:Sodium Chloride; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D012965:Sodium Chloride; D003300:Copper; D002266:Carboxymethylcellulose Sodium; C030973:cupric oxide
keywords: Antibacterial; Carboxymethylcellulose.; Copper oxide nanoparticle; Hydrogel