title: [Nutrigenetics and nutrigenomics - application of omics technologies in optimization of human nutrition].
abstract: Nowadays nutrigenetics and nutrigenomics are perceived as one of the most important research areas ensuring better understanding of an impact of nutrition on human health. Since such researches are interdisciplinary in type, there is a problem with their widespread acceptance and practical clinical application of obtained results. Understanding the new ideas and hypotheses published in researches on nutrigenetics/nutrigenomics requires some knowledge of genetics, biochemistry, molecular biology, and capabilities and limitations that are associated with the use of statistical and bioinformatic analysis, and above all omics research technologies (genomics, transcriptomics, proteomics, metabolomics). Highly efficient genome and proteome analysis techniques allow to obtain data necessary for profiling of an individual patient. The main problem is still our insufficient knowledge of cell physiology and biochemistry. The vast amount of information is obtained with the use of omics technologies what makes it difficult to interpret and infer. An unquestionable advantage of this type of research is the possibility to utilize system analysis (system biology) which is important in the context of a holistic interpretation of biological phenomena. This review is an attempt to present the main hypotheses and objectives which are carried out by researchers in nutrigenetics/nutrigenomics. This article describes the most important directions of research and anticipated results that are related to the practical use of nutritional genomics as well as the critical assessment of the possible impact of future developments on public health.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Panczyk
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D023281:Genomics / Q000639:trends*; D006293:Health Promotion; D006801:Humans; D008659:Metabolic Diseases / Q000517:prevention & control; D009369:Neoplasms / Q000517:prevention & control; D054647:Nutrigenomics / Q000639:trends*; D009747:Nutritional Physiological Phenomena