title: Efficacy of Pelvisoft® Biomesh for cystocele repair: assessment of long-term results.
abstract: OBJECTIVE
  To our knowledge a study regarding the efficacy of Pelvisoft® Biomesh for cystocele repair has not previously been reported in the literature. The aim of our study was to assess the long-term efficacy, subjective outcomes and complications in the use of a non-synthetic porcine skin mesh graft (Pelvisoft® Biomesh) associated with transvaginal anterior colporrhaphy in the treatment of cystocele prolapse.
  
  
  METHODS
  A retrospective study was performed at a single centre. Thirty-three women aged 35-77 years underwent cystocele repair using Pelvisoft® graft between December 2005 and June 2009. Twenty-nine women who underwent transvaginal cystocele repair with Pelvisoft® Biomesh for over a 2 years period were assessed. Four patients were lost to follow-up. Cystocele repair was performed via the vaginal route using Pelvisoft® Biomesh implant by inserting it in the anterior vaginal wall.
  
  
  RESULTS
  The median follow-up time was 54.0 months. The rate of recurrence was 17.3%. A total of 6.9% of patients presented early mesh exposure treated by conservative treatment. The mean PFDI-20 score was 72.2. Among sexually active women, the mean PISQ 12 was 33.9 but 56.2% had dyspareunia. After surgery, 6 patients had de novo intercourse.
  
  
  CONCLUSIONS
  Our results show that the use of Pelvisoft® biomaterial associated with anterior colporrhaphy for cystocele repair appears to be safe with acceptable failure and complication rates at long term. Nevertheless, an adverse impact on sexual function was reported by the majority of patients.
authors.affiliation: Rouen University Hospital, Ch. Nicolle, 76031 Rouen, France.
authors.forename: Erwann
authors.initials: E
authors.lastname: Le Long
authors.affiliation: Rouen University Hospital, Ch. Nicolle, 76031 Rouen, France.
authors.forename: John David
authors.initials: JD
authors.lastname: Rebibo
authors.affiliation: Rouen University Hospital, Ch. Nicolle, 76031 Rouen, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Caremel
authors.affiliation: Rouen University Hospital, Ch. Nicolle, 76031 Rouen, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grise
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use*; D052858:Cystocele / Q000601:surgery*; D005260:Female; D006801:Humans; D008488:Medical Illustration; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013526:Surgical Mesh / Q000009:adverse effects; D013552:Swine; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000601:surgery; D014621:Vagina / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials