title: Association of the immature platelet fraction with sepsis diagnosis and severity.
abstract: Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity.
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Rodolfo Monteiro
authors.initials: RM
authors.lastname: Enz Hubert
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Melina Veiga
authors.initials: MV
authors.lastname: Rodrigues
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Bruna Dolci
authors.initials: BD
authors.lastname: Andreguetto
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Thiago M
authors.initials: TM
authors.lastname: Santos
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: de Fátima Pereira Gilberti
authors.affiliation: Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
authors.forename: Vagner
authors.initials: V
authors.lastname: de Castro
authors.affiliation: Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
authors.forename: Joyce M
authors.initials: JM
authors.lastname: Annichino-Bizzacchi
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Desanka
authors.initials: D
authors.lastname: Dragosavac
authors.affiliation: Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Carvalho-Filho
authors.affiliation: 1] Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil [2] Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
authors.forename: Erich Vinicius
authors.initials: EV
authors.lastname: De Paula
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets; D002097:C-Reactive Protein; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000473:pathology; D018805:Sepsis / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein