title: Ionic liquids for improving the extraction of NSAIDs in water samples using dispersive liquid-liquid microextraction by high performance liquid chromatography-diode array-fluorescence detection.
abstract: A rapid, sensitive and efficient analytical method based on the use of ionic liquids for determination of non-steroidal anti-inflammatory drugs (NSAIDs) in water samples was developed. High-performance liquid chromatography equipped with a diode array and fluorescence detector was used for quantification of ketoprofen, ibuprofen and diclofenac in tap and river water samples. This new method relies on the use of two ionic liquids with multiple functionalities: one functions as an extraction solvent (1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]), and the other changes the polarity in the aqueous medium (1-butyl-3-methylimidazolium tetrafluoroborate, ([BMIM][BF4]). Factors such as the type and volume of the ILs and dispersive solvent, sample volume, and centrifugation time were investigated and optimized. The optimized method exhibited good precision, with relative standard deviation values between 2% and 3%, for the three NSAIDs. Limits of detection achieved for all of the analytes were between 17 and 95 ng mL(-1), and the recoveries ranged from 89% to 103%. Furthermore, the enrichment factors ranged from 49 to 57. The proposed method was successfully applied to the analysis of NSAIDs in tap and river water samples.
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Electronic address: ctoledoneira@ciq.uchile.cl.
authors.forename: Carla
authors.initials: C
authors.lastname: Toledo-Neira
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Álvarez-Lueje
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004008:Diclofenac / Q000032:analysis / Q000737:chemistry; D005453:Fluorescence; D007052:Ibuprofen / Q000032:analysis / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D007660:Ketoprofen / Q000032:analysis / Q000737:chemistry; D059627:Liquid Phase Microextraction; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000737:chemistry
chemical_list: C412621:1-butyl-3-methylimidazolium hexafluorophosphate; C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D052578:Ionic Liquids; D014874:Water Pollutants, Chemical; D004008:Diclofenac; D007660:Ketoprofen; D007052:Ibuprofen
keywords: Dispersive liquid–liquid microextraction; High performance liquid chromatography; Ionic liquids; NSAIDs