title: Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate.
abstract: This study developed an adhesive and transferable free-standing (FS) film with dual function of osteoinductivity and antibacterial activity, which was obtained by sequentially assembling vancomycin immobilized oxidized sodium alginate and dexamethasone encapsulated chitosan coated BSA nanoparticles on a poly-dopamine layer. The FS films enabled the dual release of vancomycin and dexamethasone. The FS films had excellent osteoinductivity and antibacterial activity by cell culture and antibacterial assay. The FS film was detached from substrates and transferred to non-fouling surfaces by a wet transfer method, which demonstrated that the adhesive FS film is potential to modify biopolymers with non-fouling surfaces in mild and biocompatible conditions for biomedical applications.
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Han
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China.
authors.forename: Zhen-ming
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China. Electronic address: luxiong_2004@163.com.
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China.
authors.forename: Chao-ming
authors.initials: CM
authors.lastname: Xie
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Ke-feng
authors.initials: KF
authors.lastname: Wang
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China.
authors.forename: Xiao-lang
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Department of Mechanical and Aerospace Engineering and Materials Characterisation and Preparation Facility, Hong Kong University of Science and Technology, Hong Kong, China.
authors.forename: Yong-hui
authors.initials: YH
authors.lastname: Ding
authors.affiliation: Department of Mechanical and Aerospace Engineering and Materials Characterisation and Preparation Facility, Hong Kong University of Science and Technology, Hong Kong, China.
authors.forename: Lu-tao
authors.initials: LT
authors.lastname: Weng
mesh_terms: D000269:Adhesives / Q000138:chemical synthesis* / Q000737:chemistry; D000464:Alginates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D057219:Biofouling / Q000517:prevention & control; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry; D003907:Dexamethasone / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000269:Adhesives; D000464:Alginates; D000900:Anti-Bacterial Agents; D006603:Hexuronic Acids; D007211:Indoles; D011108:Polymers; C568283:polydopamine; D012710:Serum Albumin, Bovine; D014640:Vancomycin; D003907:Dexamethasone; D020723:Glucuronic Acid; D048271:Chitosan
keywords: BSA nanoparticles; Dexamethasone; Free-standing films; Oxidized alginate; Self-assembly; Vancomycin