title: Thirty years of intracrinology.
abstract: BACKGROUND
  Intracrinology is the study of the intracellular actions, regulation, trafficking, and interactions of extracellular signaling peptides/proteins.
  
  
  METHODS
  We describe the development of intracrine biology since the term was defined in 1984.
  
  
  RESULTS
  Intracrine biology plays a role in many normal and pathological processes and represents a fertile field for the development of novel therapeutics.
  
  
  CONCLUSIONS
  Although 30 years old, the field of intracrinology is only now becoming widely accepted. Intracrine principles can be applied to the investigation of physiological processes and to the development of new therapies.
authors.affiliation: Research Division, Ochsner Health System, New Orleans, LA.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Re
keywords: Angiotensin II; cytoplasmic and nuclear receptors; intracellular signaling peptides and proteins; intracrine; intracrinology; renin-angiotensin systems