title: A pain in the NEC: research challenges and opportunities.
abstract: This lecture will describe how the properties of heparin-binding EFG-like growth factor (HB-EGF) can be utilized to protect the intestines from necrotizing enterocolitis (NEC), to augment the effects of stem cells in the treatment of NEC, and to improve the production of tissue-engineered intestine. It will also explore the role of the enteric nervous system in the development of NEC.
authors.affiliation: The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: gailbesner@nationwidechildrens.org.
authors.forename: Gail E
authors.initials: GE
authors.lastname: Besner
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control / Q000628:therapy*; D066257:Heparin-binding EGF-like Growth Factor / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000187:drug effects*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012106:Research; D013234:Stem Cells / Q000187:drug effects*; D023822:Tissue Engineering
chemical_list: D066257:Heparin-binding EGF-like Growth Factor; D020011:Protective Agents
keywords: HB-EGF; Intestine; Necrotizing enterocolitis; Tissue engineering