title: Sensitivity of Noninvasive Cardiac Electrophysiological Imaging to Variations in Personalized Anatomical Modeling.
abstract: OBJECTIVE
  Noninvasive cardiac electrophysiological (EP) imaging techniques rely on anatomically-detailed heart-torso models derived from high-quality tomographic images of individual subjects. However, anatomical modeling involves variations that lead to unresolved uncertainties in the outcome of EP imaging, bringing questions to the robustness of these methods in clinical practice. In this study, we design a systematic statistical approach to assess the sensitivity of EP imaging methods to the variations in personalized anatomical modeling.
  
  
  METHODS
  We first quantify the variations in personalized anatomical models by a novel application of statistical shape modeling. Given the statistical distribution of the variation in personalized anatomical models, we then employ unscented transform to determine the sensitivity of EP imaging outputs to the variation in input personalized anatomical modeling.
  
  
  RESULTS
  We test the feasibility of our proposed approach using two of the existing EP imaging methods: epicardial-based electrocardiographic imaging and transmural electrophysiological imaging. Both phantom and real-data experiments show that variations in personalized anatomical models have negligible impact on the outcome of EP imaging.
  
  
  CONCLUSIONS
  This study verifies the robustness of EP imaging methods to the errors in personalized anatomical modeling and suggests the possibility to simplify the process of anatomical modeling in future clinical practice.
  
  
  CONCLUSIONS
  This study proposes a systematic statistical approach to quantify anatomical modeling variations and assess their impact on EP imaging, which can be extended to find a balance between the quality of personalized anatomical models and the accuracy of EP imaging that may improve the clinical feasibility of EP imaging.
authors.forename: Azar
authors.initials: A
authors.lastname: Rahimi
authors.lastname: Linwei Wang
mesh_terms: D057791:Cardiac Imaging Techniques / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008955:Models, Cardiovascular; D057285:Precision Medicine / Q000379:methods*