title: [Analysis of factors associated with recurrence of cervical intraepithelial neoplasia after loop electrosurgical excision procedure].
abstract: OBJECTIVE
  To explore the factors associated with recurrence of cervical intraepithelial neoplasia (CIN) after loop electrosurgical excision procedure (LEEP).
  
  
  METHODS
  A total of 236 patients with CIN owing to high-risk human papillomavirus (HPV) infection underwent LEEP and followed up with thinprep cytologic test (TCT), HPV genotype test and biopsy histology.
  
  
  RESULTS
  Among them, 22 patients (9.3%) developed recurrent disease at 12 months post-LEEP. And the persistent infection rate of high-risk HPV was 10.6% (25/236). The odds ratio for recurrent CIN in patients with persistent infection of high-risk HPV was 38.9 (P < 0.01). Recurrent rate was associated with HPV DNA load pre-LEEP (P < 0.05), HPV16 infection (P < 0.01) and positive margin (P < 0.05).
  
  
  CONCLUSIONS
  HPV DNA load >1 000 RLU/CO, HPV 16 infection and positive margin are risk factors for recurrence. And persistent infection of high-risk HPV is a significant predictor of recurrent CIN.
authors.affiliation: Second People's Hospital, Liaocheng 252600, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Shanghai Haitian Pharmaceutical Science Development Co., Ltd. Email: connie2092@sina.com.
authors.forename: Yankang
authors.initials: Y
authors.lastname: Duan
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections; D012008:Recurrence; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms; D002578:Uterine Cervical Dysplasia