title: The Association of HLA Class I and II Antigens in Teenagers with Caries Experience.
abstract: OBJECTIVE
  There have been reports of a relationship between human histocompatibility antigen types and increased incidence of dental caries. The association between specific patterns of HLA genetic inheritance is not clear and not well studied. The aim of the study was to investigate the relationship between MHC alleles and DMFT index in 65 teenagers.
  
  
  METHODS
  Sixty-five teenagers were recruited from the students of elementary school of the university campus and the patients of the Ataturk University Dental School hospital. Low-resolution typing for the HLA-A, B, C and HLA-DR/DQ were performed by PCR-SSP method using SSP HLA class I generic DNA Typing Tray.
  
  
  RESULTS
  The results showed that HLA-DRB1*04 and -DRB1*07 frequencies were significantly higher (30.4% and 26.08% respectively) in DMFT≥1 group as compared with DMFT:0 group (10.5% and 5.26%), (p:0.168, OR:3.719; p:0.117, OR:6.353). Although frequencies of HLA-A*2, -B*27 and -B*51 alleles were increased in DMFT≥1 group, they were not statically important. HLA-DRB1*11 were found to be more common in DMFT: 0 groups.
  
  
  CONCLUSIONS
  The pathogens involve in caries induce immune systems and response via the given HLA alleles could be important.
authors.affiliation: Atatürk University, School of Dentistry, Department of Conservative Dentistry, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yildiz
authors.affiliation: Atatürk University, School of Medicine, Department of Medical Biology and Genetic, Erzurum, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Pirim
authors.affiliation: Atatürk University, School of Dentistry, Department of Conservative Dentistry, Erzurum, Turkey.
authors.forename: Yusuf Ziya
authors.initials: YZ
authors.lastname: Bayindir
authors.affiliation: Atatürk University, School of Medicine, Department of Pediatry, Erzurum, Turkey.
authors.forename: Hasim
authors.initials: H
authors.lastname: Olgun
authors.affiliation: Atatürk University, School of Medicine, Department of Medical Biology and Genetic, Erzurum, Turkey.
authors.forename: Fulya
authors.initials: F
authors.lastname: Temel
keywords: Caries experience; DMFT; HLA