title: Interactions of flavonoids with ionotropic GABA receptors.
abstract: In this overview, we highlight some recent advances in the interaction of natural and synthetic flavonoids with ionotropic GABA receptors. Examples of positive, negative, and neutralizing allosteric modulators as well as allosteric agonists are given. Flavonoids appear to act via multiple binding sites on GABA receptors. Unraveling these active sites remains a major task.
authors.affiliation: Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Jane R
authors.initials: JR
authors.lastname: Hanrahan
authors.affiliation: Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Mary
authors.initials: M
authors.lastname: Chebib
authors.affiliation: School of Medical Sciences, Pharmacology, The University of Sydney, Sydney, New South Wales, Australia. Electronic address: graham.johnston@sydney.edu.au.
authors.forename: Graham A R
authors.initials: GA
authors.lastname: Johnston
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D000818:Animals; D001665:Binding Sites; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D018079:Receptors, GABA / Q000187:drug effects* / Q000378:metabolism
chemical_list: D005419:Flavonoids; D018079:Receptors, GABA
keywords: Flavones; Flavonoids; GABA; Isoflavones; Modulators