title: [A prospective, randomized, controlled clinical study of Huai Qi Huang granules in treatment of childhood primary nephrotic syndrome].
abstract: OBJECTIVE
  To study the efficacy of Huai Qi Huang granules in the treatment of childhood primary nephrotic syndrome.
  
  
  METHODS
  Between July 2009 and December 2011, patients who were admitted and diagnosed for the first time as childhood primary nephrotic syndrome were randomized into a treatment group (Huai Qi Huang granules plus glucocorticoid; n=23) and a control group (glucocorticoid alone; n=19) for a prospective study. The two groups were compared for regression time of edema, time to urinary protein clearance, relapse rate, incidence of infection, dosage of glucocorticoid, and humoral and cellular immunological indicators.
  
  
  RESULTS
  There were no significant differences in regression time of edema, time to urinary protein clearance, and relapse rate between the treatment and control groups (P>0.05). The treatment group had significantly lower incidence of infection and daily dose of glucocorticoid (at month 6) than the control group (P<0.05). Humoral and cellular immunological indicators showed no significant differences between the two groups (P>0.05). No Huai Qi Huang-related adverse events were observed in this study.
  
  
  CONCLUSIONS
  Huai Qi Huang granules treatment can reduce the dose of glucocorticoid and the incidence of infection in children with primary nephrotic syndrome and has a favourable safety.
authors.affiliation: Department of Nephrology, Capital Institute of Pediatrics, Beijing 100020, China. caoli9114@sina.com.
authors.forename: Hai-Yun
authors.initials: HY
authors.lastname: Geng
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Da-Kun
authors.initials: DK
authors.lastname: Chen
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Chu
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Ji
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Tu
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Li
authors.forename: Hua-Rong
authors.initials: HR
authors.lastname: Li
authors.forename: Pei-Wei
authors.initials: PW
authors.lastname: Du
mesh_terms: D027885:Astragalus propinquus; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; C027492:Huang Qi