title: [Analyses of risk factors for postoperative recurrence after curative resection of stage III A-N2 non-small cell lung cancer].
abstract: OBJECTIVE
  To explore the patterns of mediastinal lymph node metastases and prognostic factors of recurrence in patients undergoing curative resection of stage IIIA-N2 non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 92 patients underwent curative operation and pathologically diagnosed as stage IIIA-N2 NSCLC were retrospectively reviewed. The clinicopathological data were compared between the recurrence and non-recurrence groups. And the potential prognostic factors were included for multivariate analysis using Cox proportional hazard model.
  
  
  RESULTS
  The 3 and 5-year recurrence rates were 61.0% and 70.2% respectively. For univariate analysis, the prognostic factors were number of metastatic lymph nodes, positive lymph node ratio, number of metastatic mediastinal lymph nodes (MLN), positive MLN ratio, number of MLN metastasis > 3, multiple station metastasis, trans-regional metastasis and multi-zonal metastasis. A multivariate analysis using Cox regression identified 2 independent factors of prognosis: trans-regional MLN metastasis (P = 0.035) and number of MLN metastasis >3 (P = 0.045). The recurrence risk of patients with trans-regional MLN metastasis was 2.0 times higher than those with regional MLN metastasis while the recurrence risk of patients with number of MLN metastasis >3 was 2.2 times higher than those with number of MLN metastasis of 1-3.
  
  
  CONCLUSIONS
  Recurrence risk of stage IIIA-N2 non-small cell lung cancer (NSCLC) after curative resection may be estimated by location and number of MLN metastasis. And the subgroup with trans-regional MLN metastasis and number of MLN metastasis >3 carries the highest risk of recurrence.
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Qiang
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China. Email: guoyongqing@yahoo.com.
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Qiduo
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Yanchu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Throacic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Deruo
authors.initials: D
authors.lastname: Liu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung; D006801:Humans; D008175:Lung Neoplasms; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008482:Mediastinum; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors