title: MicroRNAs in B-cells: from normal differentiation to treatment of malignancies.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs that play important post-transcriptional regulatory roles in a wide range of biological processes. They are fundamental to the normal development of cells, and evidence suggests that the deregulation of specific miRNAs is involved in malignant transformation due to their function as oncogenes or tumor suppressors. We know that miRNAs are involved in the development of normal B-cells and that different B-cell subsets express specific miRNA profiles according to their degree of differentiation. B-cell-derived malignancies contain transcription signatures reminiscent of their cell of origin. Therefore, we believe that normal and malignant B-cells share features of regulatory networks controlling differentiation and the ability to respond to treatment. The involvement of miRNAs in these processes makes them good biomarker candidates. B-cell malignancies are highly prevalent, and the poor overall survival of patients with these malignancies demands an improvement in stratification according to prognosis and therapy response, wherein we believe miRNAs may be of great importance. We have critically reviewed the literature, and here we sum up the findings of miRNA studies in hematological cancers, from the development and progression of the disease to the response to treatment, with a particular emphasis on B-cell malignancies.
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aarhus University, Denmark.
authors.forename: Sara Correia
authors.initials: SC
authors.lastname: Marques
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Maria Bach
authors.initials: MB
authors.lastname: Laursen
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Julie Støve
authors.initials: JS
authors.lastname: Bødker
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Malene Krag
authors.initials: MK
authors.lastname: Kjeldsen
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Falgreen
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schmitz
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg University, Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Bøgsted
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg University, Denmark. Clinical Cancer Research Center, Aalborg University Hospital, Denmark.
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Johnsen
authors.affiliation: Department of Haematology, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg University, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Dybkaer
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D014408:Biomarkers, Tumor; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D019337:Hematologic Neoplasms / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D009857:Oncogenes; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs