title: Serum amyloid A is a novel prognostic biomarker in hepatocellular carcinoma.
abstract: OBJECTIVE
  To investigate the prognostic value of serum amyloid A (SAA) in patients with hepatocellular carcinoma (HCC) undergoing surgery.
  
  
  METHODS
  Preoperative serum samples of 328 patients with HCC who underwent curative resection and of 47 patients with benign liver lesion were assayed. Serum levels of SAA were measured by enzyme-linked immunosorbent assay and its correlations with clinicopathological characteristics and survival were explored.
  
  
  RESULTS
  Levels of SAA were significantly higher in patients with HCC than those with benign liver lesion. There were strong correlations between preoperative serum SAA level and tumor size and more advanced BCLC stage. On univariate analysis, elevated SAA was associated with reduced disease-free survival and overall survival (p=0.001 and 0.03, respectively). Multivariate analyses showed that serum SAA level was an independent prognostic factor for overall survival (hazard ratio 2.80, p=0.01).
  
  
  CONCLUSIONS
  High SAA serum level is a novel biomarker for the prognosis of HCC patients.
authors.affiliation: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Shanghai, China E-mail : qiu.shuangjian@zs-hospital.sh.cn.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Ni
authors.forename: Yong
authors.initials: Y
authors.lastname: Yi
authors.forename: Yi-Peng
authors.initials: YP
authors.lastname: Fu
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: He
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Cai
authors.forename: Jia-Xing
authors.initials: JX
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Shuang-Jian
authors.initials: SJ
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein