title: Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL-8 Level.
abstract: OBJECTIVE
  To estimate the stage of histological chorioamnionitis (h-CAM) antenatally using clinical data.
  
  
  METHODS
  Four hundred and twenty-eight singleton mothers were recruited. Clinical data including the levels of white blood cell count (WBC), C-reactive protein (CRP), amniotic fluid interleukin-8 (AF-IL-8) at Cesarean section, and maternal body temperature (MBT) were collected.
  
  
  RESULTS
  Histological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h-CAM stage III. AF-IL-8 (odds ratio: 8.5, 95% CI: 5.1-14.8, P < 0.0001) and MBT (odds ratio: 2.3, 95% CI: 1.13-4.1, P = 0.0192) were independent risk factors for h-CAM. The cutoff value of AF-IL-8 for predicting each stage of h-CAM (stage I or higher, stage II or higher, and stage III) were ≥9.9 ng/mL, ≥17.3 ng/mL, and ≥55.9 ng/mL, respectively.
  
  
  CONCLUSIONS
  The stage of h-CAM was able to be predicted accurately by the level of AF-IL-8 before delivery.
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoneda
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Arihiro
authors.initials: A
authors.lastname: Shiozaki
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Ito
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoneda
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Inada
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Yonezawa
authors.affiliation: Department of Public Health Faculty of Medicine, University of Toyama, Toyama, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Kigawa
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology* / Q000378:metabolism; D001831:Body Temperature / Q000276:immunology; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism; D002821:Chorioamnionitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology* / Q000378:metabolism; D007958:Leukocyte Count; D036801:Parturition / Q000276:immunology; D011247:Pregnancy
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8; D002097:C-Reactive Protein
keywords: Amniotic fluid; body temperature; histological chorioamnionitis; interleukin-8; preterm labor