title: Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers.
abstract: Racemic-protected α-ethynylphenylalanine was synthesized from DL-2-benzylserine using α-benzylserinal as key intermediate and was successfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.
authors.affiliation: UNIV. NIMES, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France, zohra.benfodda@unimes.fr.
authors.forename: Z
authors.initials: Z
authors.lastname: Benfodda
authors.forename: D
authors.initials: D
authors.lastname: Bénimélis
authors.forename: M
authors.initials: M
authors.lastname: Jean
authors.forename: J-V
authors.initials: JV
authors.lastname: Naubron
authors.forename: V
authors.initials: V
authors.lastname: Rolland
authors.forename: P
authors.initials: P
authors.lastname: Meffre
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D001593:Benzyl Compounds / Q000737:chemistry*; D002942:Circular Dichroism; D008968:Molecular Conformation; D012694:Serine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001593:Benzyl Compounds; C521837:alpha-benzylserine; C408243:p-ethynylphenylalanine; D012694:Serine; D000409:Alanine