title: Oligonol supplementation modulates plasma volume and osmolality and sweating after heat load in humans.
abstract: Oligonol is a low-molecular-weight polyphenol that possesses antioxidant and anti-inflammatory properties. This study investigated the effects of Oligonol supplementation on sweating response, plasma volume (PV), and osmolality (Osm) after heat load in human volunteers. We conducted a placebo-controlled crossover trial. Participants took a daily dose of 200 mg Oligonol or placebo for 1 week. After a 2-week washout period, the subjects were switched to the other study arm. As a heat load, half-body immersion into hot water (42°C±0.5°C for 30 min) was performed in an automated climate chamber. Tympanic and mean body temperature (Tty, mTb) and whole-body sweat loss volume (WBSLV) were measured. Changes in PV, Osm, and serum levels of aldosterone and sodium were analyzed. Oligonol intake attenuated increases in Tty, mTb, and WBSLV after heat load compared with the placebo (P<.01, P<.05, and P<.01, respectively). In addition, serum aldosterone was maintained at a relatively low degree and serum sodium was maintained at a relatively high degree with Oligonol compared to the placebo (P<.01 and P<.05, respectively). However, PV decreased and Osm increased significantly with Oligonol compared to the placebo (P<.05 and P<.05, respectively). This study demonstrates that Oligonol supplementation for 1 week can attenuate elevation of body temperature and excessive sweating under heat load in healthy humans, but interpretation of the results requires caution due to the potent diuretic effect of Oligonol.
authors.affiliation: 1 Department of Physiology, College of Medicine, Soonchunhyang University , Cheonan, Korea.
authors.forename: JeongBeom
authors.initials: J
authors.lastname: Lee
authors.forename: YoungOh
authors.initials: Y
authors.lastname: Shin
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001831:Body Temperature / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D010636:Phenols / Q000008:administration & dosage*; D010953:Plasma Volume / Q000187:drug effects*; D012964:Sodium / Q000097:blood; D013542:Sweat; D013546:Sweating / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010636:Phenols; C514283:oligonol; D000450:Aldosterone; D002392:Catechin; D012964:Sodium
keywords: Oligonol; aldosterone; diuretic; plasma osmolality; plasma volume; sodium; sweat; temperature