title: Fluorescence turn-on chemosensor for highly selective and sensitive detection and bioimaging of Al(3+) in living cells based on ion-induced aggregation.
abstract: Herein, a new fluorescence turn-on chemosensor 2-(4-(1,2,2-triphenylvinyl)phenoxy)acetic acid (TPE-COOH) specific for Al(3+) was presented by combining the aggregation-induced-emission (AIE) effect of tertaphenylethylene and the complexation capability of carboxyl. The introduction of carboxylic group provides the probe with good water-solubility which is important for analyzing biological samples. The recognition toward Al(3+) induced the molecular aggregation and activated the blue fluorescence of the TPE core. The high selectivity of the probe was demonstrated by discriminating Al(3+) over a variety of metal ions in a complex mixture. A detection limit down to 21.6 nM was determined for Al(3+) quantitation. Furthermore, benefiting from its good water solubility and biocompatibility, imaging detection and real-time monitoring of Al(3+) in living HeLa cells were successfully achieved. The AIE effect of the probe enables high signal-to-noise ratio for bioimaging even without multiple washing steps. These superiorities make this probe a great potential for the functional study and analysis of Al(3+) in complex biosystems.
authors.affiliation: School of Environment and Chemical Engineering, Nanchang Hangkong University , Nanchang 330063, China.
authors.forename: Shilang
authors.initials: S
authors.lastname: Gui
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Hu
authors.forename: Yulong
authors.initials: Y
authors.lastname: Jin
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.forename: Liushui
authors.initials: L
authors.lastname: Yan
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000535:Aluminum / Q000032:analysis*; D002412:Cations / Q000032:analysis; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D057230:Limit of Detection; D061848:Optical Imaging; D013267:Stilbenes / Q000737:chemistry*
chemical_list: C000601170:2-(4-(1,2,2-triphenylvinyl)phenoxy)acetic acid; D000085:Acetates; D002412:Cations; D013267:Stilbenes; D000535:Aluminum