title: [Cytogenetic abnormalities in high-risk multiple myeloma].
abstract: Multiple myeloma is a genetically complex disease. Myeloma can be divided into hyperdiploid and non-hyperdiploid subtypes. Non-hyperdiploid subtype is mainly composed of cases harboring IgH translocations, generally associated with more aggressive clinical features and shorter survival. From a comprehensive FISH tests, the lesions associated with short progression-free survival and overall survival in multivariate analysis were del(17p13), abnormalities of chromosome 1(1p deletion and 1q amplification) and an adverse immunoglobulin heavy chain gene translocation group incorporating t(4;14), t(14;16) and t(14;20). Furthermore, the high frequency of mutations in the ERK pathway (NRAS in 24%, KRAS in 27% and BRAF in 4%) indicates that the ERK pathway is crucial for myeloma development.
authors.forename: Tadao
authors.initials: T
authors.lastname: Ishida
mesh_terms: D002869:Chromosome Aberrations; D056915:DNA Copy Number Variations; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors