title: Primary synovial sarcoma of kidney: a rare differential diagnosis of renomegaly.
abstract: Synovial sarcomas (SS) are classified as subgroup of soft tissue sarcomas affecting mainly extremities of young adults. Primary SS of kidney are very rare tumours with poor prognosis. Though they have characteristic histology and immunohistochemistry (IHC) due to rarity of incidence it is difficult to diagnose them. Sometimes chromosomal rearrangement studies are required to confirm the diagnosis. We are presenting a case of 41-year-old male who was referred to our cancer centre for evaluation of left renal mass. CT scan of abdomen revealed a large left renal mass encasing the aorta. Biopsy of renal mass revealed poorly differentiated sarcoma and IHC was positive for vimentin, CD99, and BCL2 and negative for AE1, epithelial membrane antigen, and leukocyte common antigen. The patient was clinically inoperable as renal mass was encasing the aorta. So he was subsequently offered palliative chemotherapy in form of ifosfamide and adriamycin. CT abdomen shows partial response after 3 cycles of chemotherapy according to RECIST criteria.
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Gaurang
authors.initials: G
authors.lastname: Modi
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Irappa
authors.identifier: 0000-0002-8543-2413
authors.initials: I
authors.lastname: Madabhavi
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Panchal
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Asha
authors.initials: A
authors.lastname: Anand
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Apurva
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat 830016, India.
authors.forename: Sonia
authors.initials: S
authors.lastname: Parikh
authors.affiliation: Department of Radiotherapy, Government Medical College, Haldwani, Nainital, Uttarakhand 263129, India.
authors.forename: Swaroop
authors.identifier: 0000-0001-6985-9874
authors.initials: S
authors.lastname: Revannasiddaiah