title: General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation.
abstract: A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o'-disubstituted phenolic compound through two sequential C-H functionalization processes.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D012459:Salicylates / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
chemical_list: D010636:Phenols; D012459:Salicylates; D012821:Silanes; C082343:silanol; D010165:Palladium
keywords: CH activation; carboxylation; palladium; phenols; salicylic acids