title: Lewis acid template-catalyzed asymmetric diels-alder reaction.
abstract: An asymmetric Diels-Alder reaction of 2,4-dienols and methyl acrylate utilizing a chiral Zn(II)/Mg(II) bimetallic template with low catalyst loading was successfully achieved. The bimetallic Lewis acid template derived from (R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol catalyzed the Diels-Alder reaction in the presence of molecular sieves 4 Å to afford various functionalized bicyclic γ-lactones with high enantiomeric purities.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University , 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Ishihara
authors.forename: Shino
authors.initials: S
authors.lastname: Nakadachi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D058116:Lewis Acids; D009942:Organometallic Compounds; D008274:Magnesium; D015032:Zinc