title: Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model.
abstract: With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied. Anurans, with life stage comprising embryos, tadpoles and adults, have an extremely permeable skin which makes them excellent indicators of environmental health. This study evaluated the acute toxicity effects of polyaniline nanoparticles (PANI-Np) in different dispersant on embryos and larvae of Rhinella arenarum. The results showed that LC50 of PANI-Np dispersed in polyvinylpyrrolidone (PVP) were 1,500 mg/L, while LC50 by PANI-Np dispersed in PVP+PNIPAM (polyN-isopropylacrilamide) showed a highest toxicity (1,170 mg/L). The embryo teratogenicity increased with increasing exposure concentration in both kinds of PANI-Np although in PANI-Np1, there is an increased teratogenic effect associated with the polymer stabilizer PVP.
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Ibarra
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: Lucrecia
authors.initials: L
authors.lastname: Tarres
authors.affiliation: Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: Silvestre
authors.initials: S
authors.lastname: Bongiovanni
authors.affiliation: Departamento de Química, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: César A
authors.initials: CA
authors.lastname: Barbero
authors.affiliation: Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kogan
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: Viviana A
authors.initials: VA
authors.lastname: Rivarola
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina.
authors.forename: Mabel L
authors.initials: ML
authors.lastname: Bertuzzi
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X580BYA Río Cuarto, Argentina. Electronic address: eyslas@exa.unrc.edu.ar.
authors.forename: Edith I
authors.initials: EI
authors.lastname: Yslas
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D002022:Bufo arenarum; D004625:Embryo, Nonmammalian / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D023421:Models, Animal; D053758:Nanoparticles / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000814:Aniline Compounds; D013723:Teratogens; D014874:Water Pollutants, Chemical; C416807:polyaniline
keywords: Ecotoxicology; Nanoparticles; Stage-dependent susceptibility; Teratogenesis; Toxicity test