title: A concise review of non-alcoholic fatty liver disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver damage, and is critically influenced by host factors including age, gender, presence of diabetes, genetic polymorphisms and more recently by the gut microbiome. An increasing body of data suggest that NAFLD is also an independent risk factor of cardiovascular disease, which remains the commonest cause of mortality in such patients. This review focusses on the pathogenesis of NAFLD, and the evolution of new approaches to the management and treatment of NAFLD.
authors.affiliation: The Centre of Liver Research and NIHR Biomedical Research Unit in Liver Diseases, University of Birmingham and University Hospital Birmingham NHS Trust, UK. Electronic address: nwenithan@gmail.com.
authors.forename: Nwe Ni
authors.initials: NN
authors.lastname: Than
authors.affiliation: The Centre of Liver Research and NIHR Biomedical Research Unit in Liver Diseases, University of Birmingham and University Hospital Birmingham NHS Trust, UK.
authors.forename: Philip N
authors.initials: PN
authors.lastname: Newsome
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications*; D002648:Child; D050171:Dyslipidemias / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000503:physiopathology; D005260:Female; D005355:Fibrosis / Q000503:physiopathology; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D009765:Obesity / Q000150:complications; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides
keywords: Cardiovascular disease; Dyslipidaemia; Insulin resistance; Non-alcoholic fatty liver disease; Pathogenesis