title: Medical anticancer treatment of lung cancer associated with comorbidities: a review.
abstract: Comorbidities are frequent in patients with lung cancer, who are often treated with systemic anticancer therapy. The purpose of the present review is to report the adaptations recommended for the various drugs used in lung cancer treatment, in the context of a specific comorbidity. The literature was reviewed for neurologic, endocrine, hepatic, renal, digestive, cardiovascular, pulmonary, blood and systemic diseases. The comorbidities impact on the systemic anticancer treatment is poorly assessed. There are no good data with a high level of evidence and literature is often limited to experts' opinion and to case reports. We need to improve our knowledge about those patients by adequate multicentric and prospective studies and registries in order to offer them better care in term of evidence-based medicine.
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium. Electronic address: sculier@bordet.be.
authors.forename: J P
authors.initials: JP
authors.lastname: Sculier
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Botta
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: A M
authors.initials: AM
authors.lastname: Bucalau
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Compagnie
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Eskenazi
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Fischler
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Gorham
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Mans
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Rozen
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Speybrouck
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: A P
authors.initials: AP
authors.lastname: Meert
authors.affiliation: Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium.
authors.forename: Th
authors.initials: T
authors.lastname: Berghmans
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications; D015897:Comorbidity; D004066:Digestive System Diseases / Q000150:complications; D004700:Endocrine System Diseases / Q000150:complications; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D008107:Liver Diseases / Q000150:complications; D008171:Lung Diseases / Q000150:complications; D008175:Lung Neoplasms / Q000150:complications* / Q000628:therapy*; D009422:Nervous System Diseases / Q000150:complications
keywords: Biological treatment; Chemotherapy; Comorbidity; Lung cancer