title: Inhibitory effects of different lactobacilli on Candida albicans hyphal formation and biofilm development.
abstract: The aim of this study was to investigate the effects of different species of Lactobacilli on hyphal formation and biofilm development by the opportunistic fungal pathogen Candida albicans. We employed 4 different Lactobacillus species, namely L. rhamnosus, L. acidophilus, L. plantarum and L. reuteri, and 2 C. albicans strains, the reference DAY286 and its isogenic hwp1/hwp1 mutant, the FJS24 strain. As assessed by morphological analysis and quantitative colorimetric assays, Lactobacillus crude filtrate supernatant fluids (CFSF) affected Candida, impairing both hyphal formation and biofilm production. The CFSF-mediated phenomenon occurred in a dilution- and time-dependent manner and was consistently observed, irrespective of the C. albicans HWP1 genotype.
authors.affiliation: Department of Health Sciences, University of Milan, Milan, Italy.
authors.forename: C F
authors.initials: CF
authors.lastname: Orsi
authors.affiliation: Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Sabia
authors.affiliation: Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ardizzoni
authors.affiliation: Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Colombari
authors.affiliation: Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: R G
authors.initials: RG
authors.lastname: Neglia
authors.affiliation: Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Peppoloni
authors.affiliation: Department of Health Sciences, University of Milan, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Morace
authors.affiliation: Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Blasi
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000502:physiology*; D025301:Hyphae / Q000254:growth & development*; D007778:Lactobacillus