title: [Efficacy and safety of circumferential pulmonary vein isolation with the anterior pulmonary vein vestibule intensive ablation and upstream therapy for atrial fibrillation].
abstract: OBJECTIVE
  To report the safety, efficacy of anterior pulmonary vein vestibule intensive ablation and upstream therapy for atrial fibrillation (AF).
  
  
  METHODS
  AF patients (n = 59) undergone radiofrequency ablation were enrolled. The paroxysmal AF patients underwent circumferential pulmonary vein isolation (CPVI). The persistent AF patients underwent CPVI plus linear ablation. During CPVI, the anterior pulmonary vein vestibule was performed intensively by prolonging the ablation time and increasing the ablation energy.Rosuvastatin and telmisartan were used for upstream therapy. The patients underwent follow-up at 1 month after ablation, and then at 3, 6, 12 and 18 months to evaluating whether the procedure is valid and safety.
  
  
  RESULTS
  During the 12 ± 6.5 months follow-up, the success rate of combination therapy was 86.4%. Preoperative and postoperative left atrial diameter was (45 ± 7) mm, and (41 ± 5) mm (P < 0.05), left atrial emptying fraction before operation was 46% ± 4%, and 54% ± 5% after operation (P < 0.05).
  
  
  CONCLUSIONS
  Combination therapy is valid and safety to treat AF. The results of 12 months follow-up showed left atrial diameter was decreased and left atrial emptying fraction was increased.
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Zhanqi
authors.initials: Z
authors.lastname: Pang
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Ma
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Li
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China.
authors.forename: He
authors.initials: H
authors.lastname: Dong
authors.affiliation: Dalian Municipal Center Hospital, Dalian 116033, China. Email: lshijun@126.com.
authors.forename: Shijun
authors.initials: S
authors.lastname: Li
mesh_terms: D020517:Atrial Appendage; D001281:Atrial Fibrillation; D001562:Benzimidazoles; D001565:Benzoates; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D005464:Fluorobenzenes; D006325:Heart Atria; D006801:Humans; D011184:Postoperative Period; D011667:Pulmonary Veins; D011743:Pyrimidines; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides; D000077333:Telmisartan
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D000077333:Telmisartan