title: Plasma pro-surfactant protein B and lung function decline in smokers.
abstract: Plasma pro-surfactant protein B (pro-SFTPB) levels have recently been shown to predict the development of lung cancer in current and ex-smokers, but the ability of pro-SFTPB to predict measures of chronic obstructive pulmonary disease (COPD) severity is unknown. We evaluated the performance characteristics of pro-SFTPB as a biomarker of lung function decline in a population of current and ex-smokers. Plasma pro-SFTPB levels were measured in 2503 current and ex-smokers enrolled in the Pan-Canadian Early Detection of Lung Cancer Study. Linear regression was performed to determine the relationship of pro-SFTPB levels to changes in forced expiratory volume in 1 s (FEV1) over a 2-year period as well as to baseline FEV1 and the burden of emphysema observed in computed tomography (CT) scans. Plasma pro-SFTPB levels were inversely related to both FEV1 % predicted (p=0.024) and FEV1/forced vital capacity (FVC) (p<0.001), and were positively related to the burden of emphysema on CT scans (p<0.001). Higher plasma pro-SFTPB levels were also associated with a more rapid decline in FEV1 at 1 year (p=0.024) and over 2 years of follow-up (p=0.004). Higher plasma pro-SFTPB levels are associated with increased severity of airflow limitation and accelerated decline in lung function. Pro-SFTPB is a promising biomarker for COPD severity and progression.
authors.affiliation: Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Janice M
authors.initials: JM
authors.lastname: Leung
authors.affiliation: Dept of Radiology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Mayo
authors.affiliation: Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Wan
authors.initials: W
authors.lastname: Tan
authors.affiliation: Dept of Community Health Sciences, Brock University, St Catharines, ON, Canada.
authors.forename: C Martin
authors.initials: CM
authors.lastname: Tammemagi
authors.affiliation: University Health Network, Ontario Cancer Institute, and Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Liu
authors.affiliation: The Canadian Centre for Applied Research in Cancer Control, Vancouver, BC, Canada The British Columbia Cancer Agency, Vancouver, BC, Canada.
authors.forename: Stuart
authors.initials: S
authors.lastname: Peacock
authors.affiliation: University Health Network, Ontario Cancer Institute, and Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Frances A
authors.initials: FA
authors.lastname: Shepherd
authors.affiliation: The Juravinsky Cancer Centre, Hamilton, ON, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Goffin
authors.affiliation: The Ottawa Hospital, Ottawa, ON, Canada.
authors.forename: Glenwood
authors.initials: G
authors.lastname: Goss
authors.affiliation: Ottawa Hospital Research Institute, Ottawa, ON, Canada.
authors.forename: Garth
authors.initials: G
authors.lastname: Nicholas
authors.affiliation: University of Calgary, Foothills Medical Centre, Calgary, AB, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Tremblay
authors.affiliation: Beatrice Hunter Cancer Research Institute and Dalhousie University, Halifax, NS, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Johnston
authors.affiliation: Institut universitaire de cardiologie et de pneumologie de Québec and Laval University, Québec, QC, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Martel
authors.affiliation: Institut universitaire de cardiologie et de pneumologie de Québec and Laval University, Québec, QC, Canada.
authors.forename: Francis
authors.initials: F
authors.lastname: Laberge
authors.affiliation: Memorial University, St John's, NL, Canada.
authors.forename: Rick
authors.initials: R
authors.lastname: Bhatia
authors.affiliation: University Health Network, Ontario Cancer Institute, and Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Heidi
authors.initials: H
authors.lastname: Roberts
authors.affiliation: University of Calgary, Foothills Medical Centre, Calgary, AB, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Burrowes
authors.affiliation: Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada.
authors.forename: Daria
authors.initials: D
authors.lastname: Manos
authors.affiliation: Dept of Diagnostic Imaging, Henderson Hospital, Hamilton, ON, Canada.
authors.forename: Lori
authors.initials: L
authors.lastname: Stewart
authors.forename: Jean M
authors.initials: JM
authors.lastname: Seely
authors.affiliation: Institut universitaire de cardiologie et de pneumologie de Québec and Laval University, Québec, QC, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Gingras
authors.affiliation: Institut universitaire de cardiologie et de pneumologie de Québec and Laval University, Québec, QC, Canada.
authors.forename: Sergio
authors.initials: S
authors.lastname: Pasian
authors.affiliation: University Health Network, Ontario Cancer Institute, and Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
authors.forename: Ming-Sound
authors.initials: MS
authors.lastname: Tsao
authors.affiliation: Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada The British Columbia Cancer Agency, Vancouver, BC, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Lam
authors.affiliation: Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada don.sin@hli.ubc.ca.
authors.forename: Don D
authors.initials: DD
authors.lastname: Sin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002170:Canada; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011498:Protein Precursors / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D037661:Pulmonary Surfactant-Associated Proteins / Q000097:blood*; D011663:Pulmonary Surfactants / Q000097:blood*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry / Q000379:methods
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; C586477:SFTPB protein, human