title: Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia.
abstract: Primary involvement of the larynx in non-Hodgkin's lymphoma (NHL) is rare. Early symptoms are non-specific and thus, it is difficult to diagnose. In the present study, the case of a 52 year-old male with hoarseness due to diffuse T-cell lymphoma as the first manifestation of precursor T-cell acute lymphoblastic leukemia is presented. Subsequent to treatment with three cycles of the etoposide and cytosine arabinoside (EA) and one cycle of the EA+L-asp chemotherapy regimens, the patient achieved complete remission. A series of consolidation therapy courses were performed subsequently. At present, the patient remains disease-free, indicating that the treatment was effective. Primary involvement of the larynx in NHL is rare. Symptoms in the early stage are subtle and non-specific and thus, diagnosis is difficult to establish. This type of tumor requires special diagnostic and therapeutic attention.
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Bobin
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tang
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Lin
keywords: laryngeal lymphoma; leukemia; non-Hodgkin’s lymphoma; primary