title: Normal karyotype in a case of acute myeloid leukemia with monocytic differentiation and hemophagocytosis by leukemic blasts.
abstract: We report the case of a 39-year-old woman with acute myeloid leukemia (AML) with monocytic differentiation showing hemophagocytosis by leukemic blasts. This phenomenon is known to be associated with certain chromosomal changes, including t(8;16), der(8), inv(8), and t(16;21); however, in this case, the patient had a normal female karyotype. To our knowledge, this is the first published case of normal karyotype AML with hemophagocytosis by leukemic blasts.
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee klsalazar@houstonmethodist.org.
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Salazar
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Claudio
authors.initials: C
authors.lastname: Mosse
mesh_terms: D000328:Adult; D002454:Cell Differentiation / Q000502:physiology*; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*; D009000:Monocytes / Q000502:physiology*
keywords: acute myeloid leukemia; erythrophagocytosis; hemophagocytosis; leukophagocytosis; monocytic differentiation; t(8;16)