title: Prostate cancer organoids: a potential new tool for testing drug sensitivity.
abstract: Recent technical advances have enabled for the first time, reliable in vitro culture of prostate cancer samples as prostate cancer organoids. This breakthrough provides the significant possibility of high throughput drug screening covering the spectrum of prostate cancer phenotypes seen clinically. These advances will enable precision medicine to become a reality, allowing patient samples to be screened for effective therapeutics ex vivo, with tailoring of treatments specific to that individual. This will hopefully lead to enhanced clinical outcomes, avoid morbidity due to ineffective therapies and improve the quality of life in men with advanced prostate cancer.
authors.affiliation: Department of Surgery, Urology Service, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: Ian
authors.initials: I
authors.lastname: Vela
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018929:Cell Culture Techniques; D019008:Drug Resistance, Neoplasm; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D008297:Male; D009940:Organoids / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents
keywords: 3D culture; in vitro; organoids; precision medicine; prostate cancer; therapeutics