title: Local antibiotic delivery systems in diabetic foot osteomyelitis: time for one step beyond?
abstract: In patients with diabetes mellitus, osteomyelitis is a severe, difficult-to-treat form of foot infection. In the management of diabetic foot osteomyelitis, carriers for local delivery of antimicrobial agents have begun to be tried, in an attempt to provide high local antibiotic concentrations. Randomized clinical trials are now expected to clarify when this new approach should be used and how it can be integrated into the overall therapeutic strategy for diabetic foot osteomyelitis.
authors.affiliation: Unit of Infectious Diseases, 2nd Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Periklis
authors.initials: P
authors.lastname: Panagopoulos
authors.affiliation: Orthopaedic Department, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Drosos
authors.affiliation: Unit of Infectious Diseases, 2nd Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece Outpatient Clinic of the Diabetic Foot, 2nd Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: Efstratios
authors.initials: E
authors.lastname: Maltezos
authors.affiliation: Outpatient Clinic of the Diabetic Foot, 2nd Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece papanasnikos@yahoo.gr.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papanas
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003646:Debridement; D017719:Diabetic Foot / Q000150:complications / Q000628:therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D010019:Osteomyelitis / Q000209:etiology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotics; delivery systems; diabetes mellitus; diabetic foot; infections; osteomyelitis; treatment