title: Association of INSIG2 polymorphism with overweight and LDL in children.
abstract: BACKGROUND
  Dyslipidemia and overweight are common issues in children. Identifying genetic markers of risk could lead to targeted interventions. A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis.
  
  
  OBJECTIVE
  To identify polymorphisms in INSIG2 which are associated with overweight (BMI ≥ 85% for age) and dyslipidemia in children.
  
  
  OBJECTIVE
  The C allele of rs7566605 would be significantly associated with BMI and LDL.
  
  
  METHODS
  We genotyped 15 SNPs in/near INSIG2 in 1,058 healthy children (53% non-Hispanic white (NHW), 37% overweight) participating in a school based study. Genotype was compared with BMI and lipid markers, adjusting for age, gender, and puberty.
  
  
  RESULTS
  We found a significant association between the SNP rs12464355 and LDL in NHW children, p < 0.001. The G allele is protective (lower LDL). A different SNP was associated with overweight in NHW: rs17047757. SNP rs7566605 was not associated with overweight or lipid levels.
  
  
  CONCLUSIONS
  We identified novel genetic associations between INSIG2 and both overweight and LDL in NHW children. Polymorphisms in INSIG2 may be important in the development of obesity through its effects on lipid regulation.
authors.affiliation: Division of Pediatric Endocrinology, University of South Alabama, Mobile, Alabama, United States of America.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Kaulfers
authors.affiliation: Department of Environmental Health, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Deka
authors.affiliation: Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Dolan
authors.affiliation: Divisions of Biostatistics and Epidemiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center and University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D050171:Dyslipidemias / Q000208:ethnology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D050177:Overweight / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013334:Students; D014481:United States / Q000208:ethnology; D044465:White People / Q000235:genetics*
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL; D008565:Membrane Proteins