title: A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs.
abstract: Clear cell acanthoma, firstly described by Degos as "an epidermal tumor with a particular aspect", although quite a rare lesion, raised an important interest because it may be easily confused with other dermatologic lesions, in the absence of a histopathological examination. Its clinical aspect is of a solitary nodule, with a red-brown varying color, with a size of 3 mm to 2 mm, sometimes covered with a thin scall. We present a case of a multiple rare cell acanthoma (seven nodular formations), having a rapid development (about two months) diagnosed in a 71-year-old patient within the lower 1/3 of the right shin.
authors.affiliation: Department of Dermatology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Dermato-Venereology Clinic, "St. Spiridon" Emergency Hospital, Iassy, Romania; lsolovastru13@yahoo.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Rotaru
authors.forename: Gabriela Mariana
authors.initials: GM
authors.lastname: Iancu
authors.forename: Laura
authors.initials: L
authors.lastname: Gheucă Solovăstru
authors.forename: Romaniţa-Firuţa
authors.initials: RF
authors.lastname: Glaja
authors.forename: Florin
authors.initials: F
authors.lastname: Grosu
authors.forename: Adriana
authors.initials: A
authors.lastname: Bold
authors.forename: Adrian
authors.initials: A
authors.lastname: Costache
mesh_terms: D049309:Acanthoma / Q000473:pathology*; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D020405:Dermis / Q000473:pathology; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D015603:Keratinocytes / Q000473:pathology; D007633:Keratins / Q000378:metabolism; D007866:Leg / Q000473:pathology*; D018655:Lymphocyte Count; D012878:Skin Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D007633:Keratins; D006003:Glycogen