title: Transcriptional profiling of whole blood: a rich source of immune biomarkers in cancer.
abstract: Immunotherapy is at the forefront of cancer treatment, and biomarkers are urgently needed to predict patient response to therapy. Recently, we discovered a 4-gene peripheral blood mRNA signature for prolonged survival in patients treated with tremelimumab. Peripheral blood mRNA is a readily accessible and under-utilized source of clinically relevant biomarkers.
authors.affiliation: Gustave L Levy Place; The Icahn School of Medicine at Mount Sinai ; New York, NY USA ; Columbia University College of Physicians and Surgeons ; New York, NY USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Saenger
authors.affiliation: Gustave L Levy Place; The Icahn School of Medicine at Mount Sinai ; New York, NY USA.
authors.forename: E
authors.initials: E
authors.lastname: de Moll
authors.affiliation: Gustave L Levy Place; The Icahn School of Medicine at Mount Sinai ; New York, NY USA ; Columbia University College of Physicians and Surgeons ; New York, NY USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
keywords: biomarker; immunotherapy; mRNA; peripheral blood; tremelimumab