title: Synergistic interplay of a non-heme iron catalyst and amino acid coligands in H2 O2 activation for asymmetric epoxidation of α-alkyl-substituted styrenes.
abstract: Highly enantioselective epoxidation of α-substituted styrenes with aqueous H2 O2 is described by using a chiral iron complex as the catalyst and N-protected amino acids (AAs) as coligands. The amino acids synergistically cooperate with the iron center in promoting an efficient activation of H2 O2 to catalyze epoxidation of this challenging class of substrates with good yields and stereoselectivities (up to 97%ee) in short reaction times.
authors.affiliation: Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus de Montilivi, 17071 Girona, Catalonia (Spain).
authors.forename: Olaf
authors.initials: O
authors.lastname: Cussó
authors.forename: Xavi
authors.initials: X
authors.lastname: Ribas
authors.forename: Julio
authors.initials: J
authors.lastname: Lloret-Fillol
authors.forename: Miquel
authors.initials: M
authors.lastname: Costas
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D019159:Nonheme Iron Proteins / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D008024:Ligands; D019159:Nonheme Iron Proteins; D013343:Styrenes; D006861:Hydrogen Peroxide
keywords: amino acids; asymmetric catalysis; bioinspired catalysis; epoxidation; non-heme iron complexes