title: Towards co-evolution of membrane proteins and metabolism.
abstract: Primordial metabolism co-evolved with the earliest membrane peptides to produce more environmentally fit progeny. Here, we map a continuous, evolutionary path that connects nascent biochemistry with simple, membrane-bound oligopeptides, ion channels and, further, membrane proteins capable of energy transduction and utilization of energy for active transport.
authors.affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: A Wilson
authors.forename: Chenyu
authors.initials: C
authors.lastname: Wei
authors.forename: Andrew
authors.initials: A
authors.lastname: Pohorille
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D058045:Artificial Cells / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D002463:Cell Membrane Permeability; D004734:Energy Metabolism; D019143:Evolution, Molecular; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism*; D056004:Molecular Dynamics Simulation; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D000069497:Origin of Life
chemical_list: D000596:Amino Acids; D007473:Ion Channels; D009842:Oligopeptides