title: Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities.
abstract: The aims of this study were to complement the current knowledge on the antioxidative composition of alcohol extracts from the fruits of Lycium barbarum and to evaluate their antioxidant activities. Three new dimers of phenolic amides, named lyciumamides A (3), B (4), and C (5), together with two monomers, N-E-coumaroyl tyramine (1) and N-E-feruloyl tyramine (2), were isolated from the fruits for the first time with the help of activity-guided chromatography. Compounds 1-5 were evaluated for their antioxidant activities in scavenging 2,2-diphenyl-1-picrylhydrazyl free radical and inhibiting lipid peroxidation in rat liver microsomes induced by ascorbate/Fe2+, cumine hydroperoxide, or CCl4/reduced form of nicotinamide-adenine dinucleotide phosphate, and the results showed that all of them exhibited strong activities, whereas compounds 1 and 2 were more potent than the reference tert-butyl-4-hydroxyanisole.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.affiliation: Shaanxi Ark Pharmaceutical Company Ltd., Xi'an 710075, China.
authors.forename: Dongwei
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Out-patient, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Yunyang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Shaanxi Ark Pharmaceutical Company Ltd., Xi'an 710075, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.|Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Tang
authors.affiliation: Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University , Xi'an 710032, China.
authors.forename: Jianzong
authors.initials: J
authors.lastname: Chen
keywords: Lycium barbarum; N-E-coumaroyl tyramine; N-E-feruloyl tyramine; antioxidant activities; lyciumamide; phenolic amides