title: Cross-sectional survey of antibiotic resistance in Escherichia coli isolated from diseased farm livestock in England and Wales.
abstract: Between 2005 and 2007, E. coli obtained from clinical diagnostic submissions from cattle, goats, pigs and sheep to government laboratories in England and Wales were tested for sensitivity to 16 antimicrobials. Resistance was most commonly observed against ampicillin, streptomycin, sulphonamides and tetracyclines. Resistance levels varied significantly between species, with isolates from cattle frequently showing the highest levels. Verocytotoxigenic E. coli (VTEC) expressed less resistance than non-VTEC. Only 19·3% of non-VTEC and 43·5% of VTEC were susceptible to all antimicrobials, while 47·1% and 30·4%, respectively, were resistant to ⩾5 antimicrobials. The resistance phenotype SSuT was commonly observed, and isolates resistant to third-generation cephalosporins were also identified. We recommend judicious antimicrobial usage in the livestock industry in order to preserve efficacy.
authors.affiliation: Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA) - Weybridge,Addlestone,Surrey,UK.
authors.forename: T E A
authors.initials: TE
authors.lastname: Cheney
authors.affiliation: Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA) - Weybridge,Addlestone,Surrey,UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Smith
authors.affiliation: APHA - Newcastle,Longbenton,Newcastle-upon-Tyne,UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Hutchinson
authors.affiliation: Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA) - Weybridge,Addlestone,Surrey,UK.
authors.forename: L A
authors.initials: LA
authors.lastname: Brunton
authors.affiliation: APHA - Bury St Edmunds, Bury St Edmunds,Suffolk,UK.
authors.forename: G
authors.initials: G
authors.lastname: Pritchard
authors.affiliation: APHA - Shrewsbury,Harlescott,Shrewsbury,UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Teale
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D003430:Cross-Sectional Studies; D024901:Drug Resistance, Multiple, Bacterial; D004739:England; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D029968:Escherichia coli Proteins / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D015511:Goat Diseases / Q000382:microbiology*; D006041:Goats; D010641:Phenotype; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D054323:Shiga-Toxigenic Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D037521:Virulence Factors; D014852:Wales
chemical_list: D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D037521:Virulence Factors; C073819:eaeA protein, E coli
keywords: Antibiotic resistance; Escherichia coli (E. coli)