title: Quantitative analysis of the association betweenCRPrs2808630 and rs1417938 polymorphisms and cancer risk.
abstract: Accumulating evidence indicates that polymorphisms in theCRPgene are important in the development of cancer. The current meta-analysis was performed to investigate the association betweenCRPpolymorphisms 3407 A>G (rs2808630) and 29 A>T (rs1417938), and the risk of developing cancer. A search of the relevant literature was conducted using the PubMed database to identify eligible studies published up until March 25, 2014. Five case-control studies involving 888 cases and 3,167 controls for the 3407 A>G polymorphism, and six case-control studies involving 3,110 cases and 5,951 controls for the 29 A>T polymorphism were included in the current meta-analysis. The pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random-effects model. Meta-analysis identified no association between theCRP3407 A>G and 29 A>T polymorphisms, and overall cancer risk. Additional stratified analysis by cancer type did not reveal any significant associations in the genetic models investigated. The findings of the present study indicated thatCRP3407 A>G and 29 A>T polymorphisms are not associated with cancer risk.
authors.affiliation: Department of Cancer Biotherapy, Cancer Institute, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China.
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China.
authors.forename: Tian-Lin
authors.initials: TL
authors.lastname: Xiao
keywords: C-reactive protein; cancer; meta-analysis; polymorphism