title: Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens.
abstract: Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.
authors.affiliation: Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Banatska 31b, 11080, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Radovic
authors.forename: Alisa
authors.initials: A
authors.lastname: Gruden-Movsesijan
authors.forename: Natasa
authors.initials: N
authors.lastname: Ilic
authors.forename: Jelena
authors.initials: J
authors.lastname: Cvetkovic
authors.forename: Slavko
authors.initials: S
authors.lastname: Mojsilovic
authors.forename: Marija
authors.initials: M
authors.lastname: Devic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Sofronic-Milosavljevic
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D015704:CD4 Antigens / Q000378:metabolism; D002490:Central Nervous System / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D015801:Helminth Proteins / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D017160:Trichinella spiralis / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth; D015704:CD4 Antigens; D016207:Cytokines; D051858:Forkhead Transcription Factors; C500522:Foxp3 protein, rat; D015801:Helminth Proteins; D053645:Interleukin-2 Receptor alpha Subunit; C097419:excretory-secretory antigen, Trichinella