title: Adaptive immune responses to Candida albicans infection.
abstract: Fungal infections are becoming increasingly prevalent in the human population and contribute to morbidity and mortality in healthy and immunocompromised individuals respectively. Candida albicans is the most commonly encountered fungal pathogen of humans, and is frequently found on the mucosal surfaces of the body. Host defense against C. albicans is dependent upon a finely tuned implementation of innate and adaptive immune responses, enabling the host to neutralise the invading fungus. Central to this protection are the adaptive Th1 and Th17 cellular responses, which are considered paramount to successful immune defense against C. albicans infections, and enable tissue homeostasis to be maintained in the presence of colonising fungi. This review will highlight the recent advances in our understanding of adaptive immunity to Candida albicans infections.
authors.affiliation: a Mucosal and Salivary Biology Division ; Dental Institute; King's College London ; London , UK.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Richardson
authors.forename: David L
authors.initials: DL
authors.lastname: Moyes
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000908:Antibodies, Fungal / Q000096:biosynthesis / Q000276:immunology; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity*; D002177:Candidiasis / Q000276:immunology* / Q000382:microbiology; D003713:Dendritic Cells; D005657:Fungal Vaccines / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral; D058847:Inflammasomes / Q000276:immunology; D051379:Mice; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D000908:Antibodies, Fungal; D005657:Fungal Vaccines; D058847:Inflammasomes
keywords: Candida albicans; adaptive immunity; fungal infection