title: The relationship between genetic variations of the cholesteryl ester transfer protein gene and coronary artery disease in Turkish subjects.
abstract: OBJECTIVE
  Although the relationship between cholesteryl ester transfer protein (CETP) and cholesterol metabolism has been characterized in recent years, the effect of CETP genetic variants associated with coronary artery disease (CAD) is still unclear. Therefore, we investigated the association between CETP gene polymorphism and levels of lipid in patients with CAD.
  
  
  METHODS
  We conducted a case-control study that included 194 unrelated subjects who underwent coronary angiography for suspected ischemic heart disease. This group was divided into 96 patients with angiographically documented CAD and 98 subjects (individuals matched for age and gender) without angiographically documented CAD (CAD-free subjects), all of whom were studied to examine the genotypic distribution of the CETP gene polymorphism in CAD. Genotyping was performed via polymerase chain reaction.
  
  
  RESULTS
  Of the 96 patients with CAD, 38 (40%) were B1B1, 42 (44%) B1B2 and 16 (16%) B2B2, compared with the control subjects, of which 35 (36%) were B1B1, 44 (45%) B1B2 and 19 (19%) B2B2. There were no significant differences between patients with CAD and control subjects in the distribution of the CETP gene polymorphism. Patients with the B1B1 genotype had lower high-density lipoprotein-cholesterol (HDL-C) and higher triglyceride (TG) levels than patients with the B2B2 genotype (p<0.05). In addition, among control subjects HDL-C levels were significantly higher in subjects with the B2B2 genotype than in subjects with the B1B1 genotype (p<0.01).
  
  
  CONCLUSIONS
  Our results suggest that genetic variations of the CTEP gene may be responsible for low HDL-C levels but may not be considered as a risk factor for CAD in the Turkish population.
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Gundogdu
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Yekta
authors.initials: Y
authors.lastname: Gurlertop
authors.affiliation: Ataturk University, Faculty of Medicine, Departments of Medical Biology and Genetics, Erzurum, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Pirim
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Sevimli
authors.affiliation: Ataturk University, Faculty of Medicine, Departments of Medical Biology and Genetics, Erzurum, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Dogan
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Sakir
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Karakelloglu
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Cardiology, Erzurum, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Senocak
keywords: Cholesteryl ester transfer protein; Coronary angiography; Coronary artery disease; Genetic