title: Urinary NGAL in patients with and without acute kidney injury in a cardiology intensive care unit.
abstract: OBJECTIVE
  To assess the diagnostic and prognostic efficacy of urine neutrophil gelatinase-associated lipocalin in patients admitted to an intensive care unit.
  
  
  METHODS
  Longitudinal, prospective cohort study conducted in a cardiology intensive care unit. The participants were divided into groups with and without acute kidney injury and were followed from admission to the intensive care unit until hospital discharge or death. Serum creatinine, urine output and urine neutrophil gelatinase-associated lipocalin were measured 24 and 48 hours after admission.
  
  
  RESULTS
  A total of 83 patients admitted to the intensive care unit for clinical reasons were assessed, most being male (57.8%). The participants were divided into groups without acute kidney injury (N=18), with acute kidney injury (N=28) and with severe acute kidney injury (N=37). Chronic diseases, mechanical ventilation and renal replacement therapy were more common in the groups with acute kidney injury and severe acute kidney injury, and those groups exhibited longer intensive care unit stay and hospital stay and higher mortality. Serum creatinine did not change significantly in the group with acute kidney injury within the first 24 hours of admission to the intensive care unit, although, urine neutrophil gelatinase-associated lipocalin was high in the groups with acute kidney injury and severe acute kidney injury (p<0.001). Increased urine neutrophil gelatinase-associated lipocalin was associated with death.
  
  
  CONCLUSIONS
  An increase in urine neutrophil gelatinase-associated lipocalin precedes variations in serum creatinine in patients with acute kidney injury and may be associated with death.
authors.affiliation: Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Mirian
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Gabriela Fulan E
authors.initials: GF
authors.lastname: Silva
authors.affiliation: Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Cassiane Dezoti da
authors.initials: CD
authors.lastname: Fonseca
authors.affiliation: Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Maria de Fatima Fernandes
authors.initials: Mde F
authors.lastname: Vattimo
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D000209:Acute-Phase Proteins / Q000652:urine*; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003325:Coronary Care Units; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D007902:Length of Stay; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D017582:Renal Replacement Therapy / Q000379:methods; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine