title: Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation.
abstract: Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.
authors.affiliation: Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD.
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Zhou
authors.affiliation: Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC.
authors.forename: Namita
authors.initials: N
authors.lastname: Kumari
authors.affiliation: Division of Cellular and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Catalano
authors.affiliation: Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC.
authors.forename: Sergei
authors.initials: S
authors.lastname: Nekhai
authors.affiliation: SABiosciences-Qiagen, Frederick, MD.
authors.forename: Jasen
authors.initials: J
authors.lastname: Wise
authors.affiliation: Laboratory of Cell and Development Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Yamada
authors.affiliation: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
authors.forename: Subhash
authors.initials: S
authors.lastname: Dhawan
keywords: XMRV infection; gene expression; heme oxygenase-1; host factors