title: Iridoid glycosides from Barleria lupulina.
abstract: Phytochemical investigation of an extract of the aerial part of Barleria lupulina resulted in the identification of four new iridoid glycosides (1-4), together with 14 known analogues (5-18). The structures of 1-4 were determined through 1D and 2D NMR spectroscopic data analysis, HRMS, and acid hydrolysis. This is the first report of iridoid glycosides with a formate group. The free-radical scavenging activity of compounds 9, 12, and 15-17 was assessed using the DPPH assay. Compounds 16 and 17 scavenged DPPH radicals weakly with IC50 values of 97.5 and 78.6 μg/mL, respectively.
authors.affiliation: School of Pharmacy, Sungkyunkwan University , Suwon, Gyeonggi-do 440-746, Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Park
authors.forename: Kyu Hyuck
authors.initials: KH
authors.lastname: Chung
authors.forename: M L Richard
authors.initials: ML
authors.lastname: Yip
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
authors.forename: Donald
authors.initials: D
authors.lastname: Senger
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D014744:Vietnam
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D057889:Iridoid Glycosides; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl