title: Clinical observation of the time course of raised intracranial pressure after subarachnoid hemorrhage.
abstract: The time course of intracranial pressure (ICP) after subarachnoid hemorrhage (SAH) is not well known. This retrospective study was conducted to investigate the occurrence and the dynamic variation of raised ICP post-SAH. ICP was prospectively studied in 120 patients with SAH who were admitted to neurocritical care within 24 h of hemorrhage. Patients underwent continuous ICP monitoring for at least 7 days, unless they died. Clinical status on admission, radiographic tests, treatment details and neurological outcome on discharge were analyzed in relation to ICP. The highest daily mean ICP and the day when ICP reduced to normal levels were assessed. Of the 120 patients studied, 112 (93.3 %) encountered ICP elevation whilst in hospital. The daily mean ICP was higher in Hunt and Hess grades IV-V patients than grades I-III patients (P = 0.01). The elevated ICP remained at a higher level for the initial 3 days (grades I-III patients) or 4 days (grades IV-V patients), after which the pressure decreased towards normal levels. The in-patient mortality was significantly increased in the high ICP variability group (P = 0.001), which was divided by the cutoff point using receiver operating characteristic curve analysis. Raised ICP mainly occurs within 8 days post-SAH, especially the initial 3-4 days. Those highlight the need for earlier management of ICP after SAH.
authors.affiliation: Department of Neurology, Chongqing Banan Hospital, Chongqing, 401320, China, Lvyuhua.kiko@gmail.com.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Lv
authors.forename: Dayan
authors.initials: D
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Lei
authors.forename: Ge
authors.initials: G
authors.lastname: Tan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology* / Q000628:therapy; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013997:Time Factors; D015898:Tomography Scanners, X-Ray Computed; D016896:Treatment Outcome