title: Effects of prediabetes mellitus alone or plus hypertension on subsequent occurrence of cardiovascular disease and diabetes mellitus: longitudinal study.
abstract: Whether prediabetes mellitus alone or combined with other disorders means a higher risk for cardiovascular disease (CVD) is still controversial. This study aimed to investigate the association between prediabetes mellitus and CVD and diabetes mellitus and to explore whether prediabetes mellitus alone or combined with other syndromes, such as hypertension, could promote CVD risks significantly. This longitudinal population-based study of 1609 residents from Shanghai in Southern China was conducted between 2002 and 2014. Participants with a history of CVD at baseline were excluded from analysis. Multivariate log-binomial regression models were used to adjust possible coexisting factors. Incidence of CVD during follow-up was 10.1%. After adjusting for age, sex, and other factors, the association between prediabetes mellitus and CVD was not observed. When hypertension was incorporated in stratifying factors, adjusted CVD risk was elevated significantly (odds ratio, 2.41; 95% confidence interval, 1.25-4.64) in prediabetes mellitus and hypertension combined group, and coexistence of diabetes mellitus and hypertension made CVD risk highly significantly increased, reaching 3.43-fold higher than the reference group. Blood glucose level within prediabetic range is significantly associated with elevated risks for diabetes mellitus after multivariable adjustment, but only when it is concurrent with other disorders, such as hypertension, it will significantly increase CVD risk.
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Miaoyan
authors.initials: M
authors.lastname: Qiu
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Weili
authors.initials: W
authors.lastname: Shen
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Song
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Liping
authors.initials: L
authors.lastname: Ju
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Wenxin
authors.initials: W
authors.lastname: Tong
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Sheng
authors.initials: S
authors.lastname: Zheng
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Yixin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.).
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases (M.Q., L.J., W.T., S.Z., Y.J., Y.W., W.W., J.T.), Shanghai Institute of Hypertension (W.S.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrinology and Metabolism, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China (X.S.); and Ping Liang Community Health Service Center, Yangpu District, Shanghai, China (H.W.). tianjypaper@163.com wlshen@sibs.ac.cn wqingw@hotmail.com.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D011446:Prospective Studies; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: cardiovascular diseases; diabetes mellitus; hypertension; prediabetic state