title: Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.
abstract: BACKGROUND
  Apolipoprotein E (ApoE) 4 isoform has been associated with elevated levels of cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs), meanwhile several polymorphisms in the LDL receptor (LDLR) gene have been associated with increased levels of total cholesterol and LDL-C.
  
  
  METHODS
  We studied 400 women from Southwest Mexico. Anthropometric features and biochemical profile were evaluated, and genotyping of single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene and rs688 in the LDLR gene was determined by TaqMan assays.
  
  
  RESULTS
  We found significant association between LDL-C (odds ratio [OR] = 3.3, 95% confidence interval [CI]: 1.9-5.7) and marginal association with TG (OR = 1.7, 95% CI: 1.0-2.9) of atherogenic risk in women carriers of the ApoE4 isoform compared to ApoE3. The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C.
  
  
  CONCLUSIONS
  Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis.
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Cahua-Pablo
authors.affiliation: Biochemistry Medical Research Unit, Specialties Hospital, Medical Center Century XXI, Mexican Institute of Social Security, México, Distrito Federal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Laboratory of Molecular Biomedicine, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Oscar Del
authors.initials: OD
authors.lastname: Moral-Hernández
authors.affiliation: Laboratory of Molecular Biomedicine, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Leyva-Vázquez
authors.affiliation: Biochemistry Medical Research Unit, Specialties Hospital, Medical Center Century XXI, Mexican Institute of Social Security, México, Distrito Federal.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Antúnez-Ortiz
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: José A
authors.initials: JA
authors.lastname: Cahua-Pablo
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico Laboratory of Molecular Biomedicine, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Luz Del Carmen
authors.initials: Ldel C
authors.lastname: Alarcón-Romero
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ortuño-Pineda
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Ma Elena
authors.initials: ME
authors.lastname: Moreno-Godínez
authors.affiliation: Laboratory of Molecular Biomedicine, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hernández-Sotelo
authors.affiliation: Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico efloresa_2@hotmail.com.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Flores-Alfaro
mesh_terms: D000328:Adult; D053327:Apolipoprotein E4 / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics*; D008078:Cholesterol, LDL / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011973:Receptors, LDL / Q000235:genetics*; D014280:Triglycerides / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D053327:Apolipoprotein E4; D008078:Cholesterol, LDL; C573412:LDLR protein, human; D011973:Receptors, LDL; D014280:Triglycerides
keywords: APoE gene; APoE isoforms; LDL-C; LDLR gene; triglycerides