title: Prostaglandin E2 labour induction with intravaginal (Minprostin) versus intracervical (Prepidil) administration at term: randomized study of maternal and neonatal outcome and patient's perception using the osgood semantic differential scales.
abstract: OBJECTIVE
  To compare the efficacy, safety, and patient's perception of two prostaglandin E2 application methods for induction of labour.
  
  
  METHODS
  Above 36th weeks of gestation, all women, who were admitted to hospital for induction of labour, were prospectively randomised to intravaginal 1 mg or intracervical 0.5 mg irrespective of cervical Bishop score. The main outcome variables were induction-to-delivery interval, number of foetal blood samples, PDA rate, rate of oxytocin augmentation, rate of vaginal delivery, and patient's perception using semantic differential questionnaire.
  
  
  RESULTS
  Thirty-nine patients were enrolled in this study. There was no statistical significant difference between the two groups in regard to perceptions of induction. The median induction delivery time using intravaginal versus intracervical administration was 29.9 versus 12.8 hours, respectively (P = 0.04). No statistically difference between the groups was detected in regard to parity, gestation age, cervical Bishop score, number of foetal blood samples, PDA rate, rate of oxytocin augmentation, and mode of birth.
  
  
  CONCLUSIONS
  Irrespective of the cervical Bishop Score, intracervical gel had a shorter induction delivery time without impingement on the women's perception of induction.
authors.affiliation: St. Marienkrankenhaus, Richard-Wagner-Straße 14, 60318 Frankfurt am Main, Germany.
authors.forename: Joscha
authors.initials: J
authors.lastname: Reinhard
authors.affiliation: St. Marienkrankenhaus, Richard-Wagner-Straße 14, 60318 Frankfurt am Main, Germany.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rösler
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Johann Wolfgang Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
authors.forename: Juping
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Marien-Hospital Witten, Marienplatz 2, 58452 Witten, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Schiermeier
authors.affiliation: Institute of Biostatistics and Mathematical Modelling, Johann Wolfgang Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Herrmann
authors.affiliation: St. Marienkrankenhaus, Richard-Wagner-Straße 14, 60318 Frankfurt am Main, Germany.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Eichbaum
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Johann Wolfgang Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Louwen
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D007743:Labor, Obstetric; D050498:Live Birth; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D010120:Oxytocics; D015237:Dinoprost; C010714:dinoprost tromethamine; D015232:Dinoprostone