title: Functionality of the chromosomal passenger complex in cancer.
abstract: The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this complex in cultured cells gives rise to chromosome segregation errors and cytokinesis failure and as a consequence the ploidy status of the next generation of cells is changed. Aneuploidy and chromosomal instability (CIN) is observed in many human cancers, but whether this may be caused by deregulation of the CPC is unknown. In the present review, we discuss if and how a dysfunctional CPC could contribute to CIN in cancer.
authors.affiliation: *Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
authors.forename: Sanne
authors.initials: S
authors.lastname: Hindriksen
authors.affiliation: *Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
authors.forename: Amanda
authors.initials: A
authors.lastname: Meppelink
authors.affiliation: *Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.
authors.forename: Susanne M A
authors.initials: SM
authors.lastname: Lens
mesh_terms: D000818:Animals; D064107:Aurora Kinase B / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D043171:Chromosomal Instability; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D020090:Chromosome Segregation; D048749:Cytokinesis; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D046912:Multiprotein Complexes / Q000502:physiology; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; C490157:CDCA8 protein, human; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C083767:INCENP protein, human; D051034:Inhibitor of Apoptosis Proteins; D046912:Multiprotein Complexes; D000077022:Survivin; C576921:AURKB protein, human; D064107:Aurora Kinase B