title: Drug-induced haemolysis, renal failure, thrombocytopenia and lactic acidosis in patients with HIV and cryptococcal meningitis: a diagnostic challenge.
abstract: Patients with HIV are at risk of both primary and secondary haematological disorders. We report two cases of patients with HIV and cryptococcal meningitis who developed severe haemolytic anaemia, thrombocytopenia, renal failure and lactic acidosis while on treatment with amphotericin B and co-trimoxazole.
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México crcamara83@hotmail.com.
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Camara-Lemarroy
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Hazael
authors.initials: H
authors.lastname: Flores-Cantu
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Hector J
authors.initials: HJ
authors.lastname: Calderon-Hernandez
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Diaz-Torres
authors.affiliation: Servicio de Neurologia, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: Hector J
authors.initials: HJ
authors.lastname: Villareal-Velazquez
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000175:diagnosis; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis / Q000188:drug therapy*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: AIDS; Cryptococcal meningitis; HIV; Haemolysis; cryptococcosis; lactic acidosis; renal failure; thrombocytopenia