title: Effects of remission speed and improvement of cognitive functions of depressed patients.
abstract: Major depressive disorder (MDD) presents neuropsychological alterations which improve after the treatment, but it might be mediated by clinical variables. Our goal is to study whether the speed of remission of MDD bears any relation to the improvement of the patients' cognitive functioning after a successful treatment. We carried out clinical and neuropsychological assessments of 51 patients with MDD. After these procedures they underwent a 24-week treatment with fluoxetine, and were assessed again with the same battery used prior to treatment. They were arranged into three groups according to how rapid their symptoms remitted. The patients with a rapid remission presented improvements in working memory, speed of information processing, and some executive functions, unlike the other groups. Rapid remitters also improved in episodic memory and executive functions more than the other patients.
authors.affiliation: Facultad de Psicología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico; Clínica de Enfermedades Crónicas y Procedimientos Especiales CECYPE, Morelia, Michoacán, Mexico. Electronic address: ferre@umich.mx.
authors.forename: Esteve
authors.initials: E
authors.lastname: Gudayol-Ferré
authors.affiliation: Departament de Metodologia, Facultat de Psicologia, Universitat de Barcelona, Institut de Recerca en Cervell, Cognició i Conducta IR3C, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Guàrdia-Olmos
authors.affiliation: Departament de Metodologia, Facultat de Psicologia, Universitat de Barcelona, Institut de Recerca en Cervell, Cognició i Conducta IR3C, Barcelona, Spain.
authors.forename: Maribel
authors.initials: M
authors.lastname: Peró-Cebollero
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D056344:Executive Function / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine
keywords: Antidepressant response; Cognitive improvement; Generalized linear models; Major depressive disorder; Neuropsychological assessment