title: Association between non-alcoholic fatty liver disease and autonomic dysfunction in a Chinese population.
abstract: BACKGROUND
  Autonomic dysfunction (AD) accompanying with chronic liver disorders led to an increased risk of mortality. However, researches that investigated the association between non-alcoholic fatty liver disease (NAFLD) and AD were insufficient.
  
  
  OBJECTIVE
  To study the association of NAFLD with AD in middle-aged and elderly Chinese adults.
  
  
  METHODS
  Four thousand nine hundred seventy-four adults aged 40 years or older were enrolled in this cross-sectional study. NAFLD was diagnosed by hepatic B-mode ultrasonography. Autonomic function was assessed using a simple EZSCAN test by measuring sudomotor function, with an AD index > 50% defined as a manifestation of AD.
  
  
  METHODS
  Pearson correlation, multiple stepwise linear regression, univariate and multivariate logistic regression was employed to examine the relationship between NAFLD and AD, controlling for potential confounders.
  
  
  RESULTS
  The prevalence of AD was significantly higher in participants with NAFLD than those without (40.75 vs. 26.86%, P < 0.0001). Age, body mass index, status of diabetes, sex, diastolic blood pressure and prevalent NAFLD, were positively correlated with AD index in multiple stepwise linear regression analysis (all P < 0.05), whereas total cholesterol was negatively related to it (P = 0.0043). Compared with the participants without NAFLD, those with NAFLD had an increased odds of the prevalent AD (odds ratio 1.38; 95% confidence interval 1.15-1.64; P = 0.0004) after controlling for multiple confounders.
  
  
  CONCLUSIONS
  The presence of NAFLD was significantly associated with AD, as indicated by abnormal sudomotor function. The association was independent from various conventional risk factors.
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and guyanyun@hotmail.com.
authors.forename: W
authors.initials: W
authors.lastname: Sun
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: K
authors.initials: K
authors.lastname: Sun
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: C
authors.initials: C
authors.lastname: Ren
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: Y
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Research and Development, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and guyanyun@hotmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.affiliation: From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, E-Institute of Shanghai Universities, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, and.
authors.forename: G
authors.initials: G
authors.lastname: Ning
mesh_terms: D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005712:Galvanic Skin Response; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D014463:Ultrasonography