title: ABO blood types and cancer risk--a cohort study of 339,432 subjects in Taiwan.
abstract: BACKGROUND
  The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined.
  
  
  METHODS
  The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort.
  
  
  RESULTS
  Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O.
  
  
  CONCLUSIONS
  Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Sun
authors.affiliation: Institute of Population Health Science, National Health Research Institutes, Zhunan, Taiwan; China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chi-Pang
authors.initials: CP
authors.lastname: Wen
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Radiological Sciences, University of California at Irvine, Irvine, CA, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wen
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Pu
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Maosheng
authors.initials: M
authors.lastname: Huang
authors.affiliation: Institute of Population Health Science, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Min Kuang
authors.initials: MK
authors.lastname: Tsai
authors.affiliation: MJ Health Management Institution, Taipei, Taiwan.
authors.forename: Chwen Keng
authors.initials: CK
authors.lastname: Tsao
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xwu@mdanderson.org.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Wong-Ho
authors.initials: WH
authors.lastname: Chow
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000401:mortality; D012307:Risk Factors; D013624:Taiwan
chemical_list: D000017:ABO Blood-Group System
keywords: ABO blood type; Cancer mortality; Cancer risk; Cohort