title: The effects of thyroid dysfunctions on insulin resistance in patients with hepatosteatosis.
abstract: BACKGROUND
  Hepatosteatosis can develop due to insulin resistance. The effect of thyroid function status on insulin sensitivity and resistance is of great interest but the data is still conflicting.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effects of thyroid dysfunctions on insulin resistance in patients with hepatosteatosis.
  
  
  METHODS
  A total of 407 patients with hepatosteatosis were divided into three groups: 102 subjects with hypothyroidism, 103 with hyperthyroidism and 202 with normal thyroid function (control group). We measured serum thyroid stimulating hormone (TSH), free T4 (FT4) and free T3 (FT3) concentrations, blood glucose and insulin levels, serum lipid levels, hepatic transaminases and the homeostasis model assessment of insulin resistance (HOMA IR).
  
  
  RESULTS
  Neither hypothyroidism patients nor hyperthyroidism patients showed significant differences in HOMA IR, glucose and insulin levels (p>0.05 for each). The frequency of insulin resistance was similar in all groups (p>0.05).
  
  
  CONCLUSIONS
  Based on our findings, hypothyroidism and hyperthyroidism are not correlated to insulin resistance in patients with hepatosteatosis. Different causes which are associated with insulin resistance should be investigated in patients with thyroid dysfunction and hepatosteatosis.
authors.affiliation: Department of Internal Medicine, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Şakir Özgür
authors.initials: ŞÖ
authors.lastname: Keşkek
authors.affiliation: Department of Internal Medicine, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Kırım
authors.affiliation: Department of Internal Medicine, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kaya
authors.affiliation: Department of Internal Medicine, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Canataroğlu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D005234:Fatty Liver / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014284:Triiodothyronine; D013972:Thyrotropin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013974:Thyroxine