title: Ag/FeCo/Ag core/shell/shell magnetic nanoparticles with plasmonic imaging capability.
abstract: Magnetic nanoparticles (NPs) have been used to separate various species such as bacteria, cells, and proteins. In this study, we synthesized Ag/FeCo/Ag core/shell/shell NPs designed for magnetic separation of subcellular components like intracellular vesicles. A benefit of these NPs is that their silver metal content allows plasmon scattering to be used as a tool to observe detection by the NPs easily and semipermanently. Therefore, these NPs are considered a potential alternative to existing fluorescent probes like dye molecules and colloidal quantum dots. In addition, the Ag core inside the NPs suppresses the oxidation of FeCo because of electron transfer from the Ag core to the FeCo shell, even though FeCo is typically susceptible to oxidation. The surfaces of the Ag/FeCo/Ag NPs were functionalized with ε-poly-L-lysine-based hydrophilic polymers to make them water-soluble and biocompatible. The imaging capability of the polymer-functionalized NPs induced by plasmon scattering from the Ag core was investigated. The response of the NPs to a magnetic field using liposomes as platforms and applying a magnetic field during observation by confocal laser scanning microscopy was assessed. The results of the magnetophoresis experiments of liposomes allowed us to calculate the magnetic force to which each liposome was subjected.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology , 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Takahashi
authors.forename: Priyank
authors.initials: P
authors.lastname: Mohan
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakade
authors.forename: Koichi
authors.initials: K
authors.lastname: Higashimine
authors.forename: Derrick
authors.initials: D
authors.lastname: Mott
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hamada
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Matsumura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taguchi
authors.forename: Shinya
authors.initials: S
authors.lastname: Maenosono
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D058085:Iron Compounds / Q000737:chemistry*; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D058085:Iron Compounds; D011107:Polylysine; D003035:Cobalt; D012834:Silver