title: Synthesis of novel bis-1,5-disubstituted-1H-tetrazoles by an efficient catalyst-free Ugi-azide repetitive process.
abstract: A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%-95%) or using mild MW-heating conditions (80%-91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds.
authors.affiliation: Departamento Química Área Ambiental, Universidad Tecnológica de Salamanca, Av. Universidad Tecnológica No. 200, Col. Ciudad Bajío, Salamanca C.P. 36750, Gto., Mexico. lcardenas@utsalamanca.edu.mx.
authors.forename: Luís E
authors.initials: LE
authors.lastname: Cárdenas-Galindo
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. blackheim66@gmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Islas-Jácome
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. karlasol08@hotmail.com.
authors.forename: Karla M
authors.initials: KM
authors.lastname: Colmenero-Martínez
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. richa@ugto.mx.
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez-Richa
authors.affiliation: Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico. rociogm@ugto.mx.
authors.forename: Rocío
authors.initials: R
authors.lastname: Gámez-Montaño
mesh_terms: D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D002412:Cations; D002625:Chemistry, Organic / Q000379:methods*; D008024:Ligands; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001386:Azides; D002412:Cations; D008024:Ligands; D013777:Tetrazoles; C045574:1H-tetrazole