title: Breaking the vicious cycle between breast cancer cells and tumor-associated macrophages.
abstract: We recently identified a vicious cycle between granulocyte macrophage colony stimulating factor (GM-CSF) arising from breast cancer cells that have undergone epithelial-mesenchymal transition (EMT) and the tumor-associated macrophage (TAM)-derived chemokine CCL18, a signaling loop that promotes tumor metastasis. Tumor-derived lactate skews GM-CSF-activated macrophages to an anti-inflammatory and immunosuppressive M2 phenotype, suggesting that breaking this cycle in combination with glycolysis inhibitors may inhibit tumor development.
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Medical Research Center ; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China ; Breast Tumor Center and Department of Oncology; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Su
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Medical Research Center ; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China ; Breast Tumor Center and Department of Oncology; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Medical Research Center ; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China ; Breast Tumor Center and Department of Oncology; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China.
authors.forename: Chonghua
authors.initials: C
authors.lastname: He
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Medical Research Center ; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China ; Breast Tumor Center and Department of Oncology; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation; Medical Research Center ; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China ; Breast Tumor Center and Department of Oncology; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University ; Guangzhou, China.
authors.forename: Erwei
authors.initials: E
authors.lastname: Song
keywords: EMT; humanized mice; tumor metabolism; tumor-associated macrophages