title: Pluronic copolymer encapsulated SCR7 as a potential anticancer agent.
abstract: Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic® copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.
authors.affiliation: Biotechnology Laboratory, PG and Research Department of Chemistry, Sacred Heart College, Kochi 682 013, India. franklinshc@gmail.com.
authors.forename: Franklin
authors.initials: F
authors.lastname: John
authors.forename: Jinu
authors.initials: J
authors.lastname: George
authors.forename: Mrinal
authors.initials: M
authors.lastname: Srivastava
authors.forename: P A
authors.initials: PA
authors.lastname: Hassan
authors.forename: V K
authors.initials: VK
authors.lastname: Aswal
authors.forename: Subhas S
authors.initials: SS
authors.lastname: Karki
authors.forename: Sathees C
authors.initials: SC
authors.lastname: Raghavan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D059766:DNA End-Joining Repair / Q000187:drug effects*; D004339:Drug Compounding; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D020442:Poloxamer / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C578537:5,6-bis(benzylideneamino)-2-mercaptopyrimidin-4-ol; D000970:Antineoplastic Agents; D008823:Micelles; D011743:Pyrimidines; D012545:Schiff Bases; D020442:Poloxamer