title: Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation.
abstract: Airway wall thickness and emphysema contribute to airflow limitation. We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available. Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r= -0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each sd increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20 mL and 30.2 mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001). A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up.
authors.affiliation: Dept of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands fmohamedhoesein@gmail.com.
authors.forename: Firdaus A A
authors.initials: FA
authors.lastname: Mohamed Hoesein
authors.affiliation: Dept of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Pim A
authors.initials: PA
authors.lastname: de Jong
authors.affiliation: Dept of Respiratory Medicine, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Jan-Willem J
authors.initials: JW
authors.lastname: Lammers
authors.affiliation: Dept of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Willem P T M
authors.initials: WP
authors.lastname: Mali
authors.affiliation: Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: Dept of Public Health, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Harry J
authors.initials: HJ
authors.lastname: de Koning
authors.affiliation: Dept of Public Health, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Carlijn
authors.initials: C
authors.lastname: van der Aalst
authors.affiliation: Center for Medical Imaging - North East Netherlands, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Matthijs
authors.initials: M
authors.lastname: Oudkerk
authors.affiliation: Dept of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Rozemarijn
authors.initials: R
authors.lastname: Vliegenthart
authors.affiliation: Dept of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAD Research Institute, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Harry J M
authors.initials: HJ
authors.lastname: Groen
authors.affiliation: Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany Diagnostic Image Analysis Group, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Bram
authors.initials: B
authors.lastname: van Ginneken
authors.affiliation: Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany Diagnostic Image Analysis Group, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Eva M
authors.initials: EM
authors.lastname: van Rikxoort
authors.affiliation: Dept of Respiratory Medicine, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Zanen
mesh_terms: D000368:Aged; D056151:Airway Remodeling; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000503:physiopathology; D013147:Spirometry / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods