title: Multimodal Imaging and Choroidal Volumetric Changes After Half-fluence PDT in Central Serous Chorioretinopathy.
abstract: OBJECTIVE
  The purpose of this study was to identify SD-OCT changes that correspond to leakage on fluorescein (FA) and indocyanine angiography (ICGA) and evaluate effect of half-fluence photodynamic therapy (PDT) on choroidal volume in chronic central serous choroidoretinopathy (CSC).
  
  
  METHODS
  Retrospective analysis of patients with chronic CSC who had undergone PDT. Baseline FA and ICGA images were overlaid on SD-OCT to identify OCT correlates of FA or ICGA hyperfluorescence. Choroidal volume was evaluated in a subgroup of eyes before and after PDT.
  
  
  RESULTS
  Twenty eyes were evaluated at baseline, of which seven eyes had choroidal volume evaluations at baseline and 3 months following PDT. SD-OCT changes corresponding to FA hyperfluorescence were subretinal fluid (73%), RPE microrip (50%), RPE double-layer sign (31%), RPE detachment (15%), and RPE thickening (8%). ICGA hyperfluoresence was correlated in 93% with hyperreflective spots in the superficial choroid. Choroidal volume decreased from 9.35 ± 1.99 to 8.52 ± 1.92 and 8.04 ± 1.7 mm(3) (at 1 and 3 months post PDT, respectively, p ≤ 0.001).
  
  
  CONCLUSIONS
  We identified specific OCT findings that correlate with FA and ICGA leakage sites. SD-OCT is a valuable tool to localize CSC lesions and may be useful to guide PDT treatment. Generalized choroidal volume decrease occurs following PDT and extends beyond PDT treatment site.
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.|b Department of Ophthalmology , Medical University Vienna , Vienna , Austria.
authors.forename: Marion R
authors.initials: MR
authors.lastname: Munk
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Ronil
authors.initials: R
authors.lastname: Shah
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Frankie
authors.initials: F
authors.lastname: Pappas
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Dina
authors.initials: D
authors.lastname: Baddar
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Brandon
authors.initials: B
authors.lastname: Wong
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Lee M
authors.initials: LM
authors.lastname: Jampol
authors.affiliation: a Department of Ophthalmology , Northwestern University, Feinberg School of Medicine , Chicago , IL , USA and.
authors.forename: Amani A
authors.initials: AA
authors.lastname: Fawzi
mesh_terms: D000328:Adult; D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D000077362:Verteporfin; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin; D007208:Indocyanine Green
keywords: Central serous choroidoretinopathy; SD-OCT; choroidal thickness; choroidal volume; fluorescein angiography; hyperfluorescence; indocyanine angiography; pigment epithelium detachment