title: Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
abstract: Elevated circulating concentrations of total L-homocysteine (thCys) and free asymmetric dimethylarginine (ADMA) are long-established cardiovascular risk factors. Low circulating L-homoarginine (hArg) concentrations were recently found to be associated with increased cardiovascular morbidity and mortality. The biochemical pathways of these amino acids overlap and share the same cofactor S-adenosylmethionine (SAM). In the present study, we investigated potential associations between hArg, L-arginine (Arg), ADMA and thCys in plasma of patients suffering from rheumatoid arthritis (RA), coronary artery disease (CAD) or peripheral artery occlusive disease (PAOD). In RA, we did not find any correlation between ADMA or hArg and thCys at baseline (n = 100) and after (n = 83) combined add-on supplementation of omega-3 fatty acids, vitamin E, vitamin A, copper, and selenium, or placebo (soy oil). ADMA correlated with Arg at baseline (r = 0.446, P < 0.001) and after treatment (r = 0.246, P = 0.03). hArg did not correlate with ADMA, but correlated with Arg before (r = 0.240, P = 0.02) and after treatment (r = 0.233, P = 0.03). These results suggest that hArg, ADMA and Arg are biochemically familiar with each other, but unrelated to hCys in RA. In PAOD and CAD, ADMA and thCys did not correlate.
authors.affiliation: Centre of Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
authors.forename: Arslan Arinc
authors.initials: AA
authors.lastname: Kayacelebi
authors.forename: Janina
authors.initials: J
authors.lastname: Willers
authors.forename: Vu Vi
authors.initials: VV
authors.lastname: Pham
authors.forename: Andreas
authors.initials: A
authors.lastname: Hahn
authors.forename: Jessica Y
authors.initials: JY
authors.lastname: Schneider
authors.forename: Sabine
authors.initials: S
authors.lastname: Rothmann
authors.forename: Jürgen C
authors.initials: JC
authors.lastname: Frölich
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tsikas
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000401:mortality; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality; D005260:Female; D006709:Homoarginine / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000401:mortality
chemical_list: D006710:Homocysteine; D006709:Homoarginine; C018524:N,N-dimethylarginine; D001120:Arginine