title: Effects of progesterone on glutamate transporter 2 and gamma-aminobutyric acid transporter 1 expression in the developing rat brain after recurrent seizures.
abstract: Seizures were induced by flurothyl inhalation. Rats were intramuscularly treated with progesterone after each seizure. Results demonstrated that glutamate transporter 2 and γ-aminobutyric acid transporter 1 expression levels were significantly increased in the cerebral cortex and hippocampus of the developing rat brain following recurrent seizures. After progesterone treatment, glutamate transporter 2 protein expression was upregulated, but γ-aminobutyric acid transporter 1 levels decreased. These results suggest that glutamate transporter 2 and γ-aminobutyric acid transporter 1 are involved in the pathological processes of epilepsy. Progesterone can help maintain a balance between excitatory and inhibitory systems by modulating the amino acid transporter system, and protect the developing brain after recurrent seizures.
authors.affiliation: Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Lingjuan
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Dingan
authors.initials: D
authors.lastname: Mao
authors.affiliation: Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Bo
keywords: glutamate; progesterone; seizure; transporter; γ-aminobutyric acid