title: The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats.
abstract: Based on the crucial roles of oxidative stress and aldose reductase on diabetic complications and the protective effect against diabetic eye complication of purple waxy corn and ginger (PWCG) together with the synergistic effect concept, we aimed to determine anticataract and antiretinopathy effects of the combined extract of purple waxy corn and ginger (PWCG). The streptozotocin diabetics with the blood glucose levels >250 mg·dL(-1) were orally given the extract at doses of 50, 100, and 200 mg/kg·BW(-1) for 10 weeks. Then, lens opacity and histopathology of retina were determined. The changes of MDA together with the activities of SOD, CAT, GPx, and AR in lens were also determined using biochemical assays. All doses of PWCG decreased lens opacity, MDA, and AR in the lens of diabetic rats. The elevation of CAT and GPx activities was also observed. The antiretinopathy property of the combined extract was also confirmed by the increased number of neurons in ganglion cell layer and thickness of total retina and retinal nuclear layer in diabetic rats. PWCG is the potential functional food to protect against diabetic cataract and retinopathy. However, further studies concerning toxicity and clinical trial are still essential.
authors.affiliation: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Paphaphat
authors.initials: P
authors.lastname: Thiraphatthanavong
authors.affiliation: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen Unieversity, Khon Kaen 40002, Thailand.
authors.forename: Jintanaporn
authors.identifier: 0000-0002-7383-2348
authors.initials: J
authors.lastname: Wattanathorn
authors.affiliation: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen Unieversity, Khon Kaen 40002, Thailand.
authors.forename: Supaporn
authors.identifier: 0000-0001-7756-1955
authors.initials: S
authors.lastname: Muchimapura
authors.affiliation: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen Unieversity, Khon Kaen 40002, Thailand.
authors.forename: Wipawee
authors.initials: W
authors.lastname: Thukham-mee
authors.affiliation: Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Kamol
authors.initials: K
authors.lastname: Lertrat
authors.affiliation: Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Bhalang
authors.initials: B
authors.lastname: Suriharn
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002386:Cataract / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003930:Diabetic Retinopathy / Q000473:pathology / Q000517:prevention & control*; D020939:Zingiber officinale / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology*; D003313:Zea mays / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013311:Streptozocin