title: Synaptic consolidation: from synapses to behavioral modeling.
abstract: Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.
authors.affiliation: School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
authors.forename: Lorric
authors.identifier: http://orcid.org/0000-0002-6485-3956
authors.initials: L
authors.lastname: Ziegler
authors.affiliation: School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
authors.forename: Friedemann
authors.identifier: http://orcid.org/0000-0003-1883-644X
authors.initials: F
authors.lastname: Zenke
authors.affiliation: School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
authors.forename: David B
authors.identifier: http://orcid.org/0000-0001-9681-425X
authors.initials: DB
authors.lastname: Kastner
authors.affiliation: School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland wulfram.gerstner@epfl.ch.
authors.forename: Wulfram
authors.identifier: http://orcid.org/0000-0002-4344-2189
authors.initials: W
authors.lastname: Gerstner
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
keywords: consolidation; modeling; synaptic tagging