title: Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low-technology methods: a systematic review and meta-analysis.
abstract: A systematic review and meta-analysis were performed to determine the effect of therapeutic hypothermia using low-technology methods, in settings with facilities for intensive care, in term or near-term infants with hypoxic-ischaemic encephalopathy on mortality, neurological morbidity at discharge and neurological morbidity at 6-24 months.
  
  
  CONCLUSIONS
  Meta-analysis of three randomised controlled studies showed that low-technology therapeutic hypothermia in an intensive care setting significantly reduced the mortality and the neurological morbidity in survivors at discharge.
authors.affiliation: Division of Neonatal Medicine, Department of Paediatrics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors.forename: Gerhardus
authors.initials: G
authors.lastname: Rossouw
authors.affiliation: Primary Health Care Directorate, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors.forename: James
authors.initials: J
authors.lastname: Irlam
authors.affiliation: Division of Neonatal Medicine, Department of Paediatrics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Horn
mesh_terms: D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000628:therapy*; D007231:Infant, Newborn
keywords: Cost-effectiveness; Hypothermia; Hypoxic-ischaemic cerebral injury; Newborn infant; Systematic review