title: A new rat model of neuropathic pain: complete brachial plexus avulsion.
abstract: Brachial plexus avulsion (BPA) is one of the major injuries in motor vehicle accidents and may result in neuropathic pain. Accumulating evidence suggests that 30-80% of BPA developed neuropathic pain in human. In our study, complete brachial plexus avulsion (C5-T1) rats model leads to the results that 37.5% of rats had long-lasting (up to 6 months) mechanical allodynia and cold allodynia. We observed the activation of astrocyte and microglial in cervical spinal cord after BPA. Complete brachial plexus avulsion mimics human nerve root traction injury following traffic accidents. The complete BPA rat model approach human injuries and can be used for further investigations.
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yuzhou
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yingjie
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China. Electronic address: laojie27@sina.com.
authors.forename: Lao
authors.initials: L
authors.lastname: Jie
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, PR China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, PR China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, PR China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xin
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001917:Brachial Plexus / Q000293:injuries*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D003080:Cold Temperature; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000378:metabolism; D009437:Neuralgia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D017288:Pain Threshold; D010812:Physical Stimulation; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism; D014110:Touch
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins
keywords: Animal models; Brachial plexus avulsion; Neuropathic pain