title: Association between VEGF -634G/C polymorphism and susceptibility to autoimmune diseases: a meta-analysis.
abstract: The role of VEGF -634G/C polymorphism has been involved in the investigations of susceptibility to autoimmune diseases, but the conclusion remains controversial. Here, we have performed a meta-analysis to clarify the relationship between them. All relevant articles updating to August 2013 were searched in PubMed and EMBASE. Crude odds ratios (ORs) with 95% confidence intervals (CIs) based on the available articles were calculated. A total of 24 independent studies associated with autoimmune disease were analyzed in our research. The results show that VEGF -634G/C polymorphism was associated with susceptibility to autoimmune disease in Asian population (C vs. G: OR=0.88, 95% CI: 0.80-0.96, P=0.543; CC vs. GG: OR=0.77, 95% CI: 0.63-0.93, P=0.787; CC+GC vs. GG: OR=0.80, 95% CI: 0.67-0.96, P=0.080 by random effects model). Nevertheless, no significant associations were found in total population or in other stratified groups. In the current meta-analysis, we reveal a significant association between VEGF -634G/C polymorphism and susceptibility to autoimmune diseases in Asian population.
authors.affiliation: Department of Life Science, Beifang University of Nationalities, Yinchuan 750021, China. Electronic address: haikui2000@hotmail.com.
authors.forename: Haikui
authors.initials: H
authors.lastname: Chen
authors.affiliation: The First Hospital of Chinese People's Liberation Army (PLA), Lanzhou 730050, China. Electronic address: tyzh2008@126.com.
authors.forename: Tianyun
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Energy & Chemical Engineering, Ningxia University, Yinchuan 750021, China. Electronic address: gongbolin@163.com.
authors.forename: Bolin
authors.initials: B
authors.lastname: Gong
authors.affiliation: Department of Life Science, Beifang University of Nationalities, Yinchuan 750021, China. Electronic address: cxh8892@163.com.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Cao
mesh_terms: D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics*; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Autoimmune diseases; Meta-analysis; Polymorphism; VEGF −634G/C