title: Synthesis of a [(14) C]-steroid intermediate: an application of a nonstabilized Horner-Wadsworth-Emmons olefination approach.
abstract: Radiolabeled steroid derivative 1 was successfully prepared using a Horner-Wadsworth-Emmons approach: a [(14) C]-label was efficiently incorporated into the C-18 position of the molecule. Previously published procedures employing other olefination methods are either not applicable due to unavailability of [(14) C]-precursors or suffer from poor reactivity.
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, 126 E. Lincoln Ave., PO Box 2000, Rahway, NJ, 07065, USA.
authors.forename: Nelo R
authors.initials: NR
authors.lastname: Rivera
authors.forename: Sumei
authors.initials: S
authors.lastname: Ren
authors.forename: David
authors.initials: D
authors.lastname: Hesk
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002250:Carbon Radioisotopes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D013256:Steroids / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002250:Carbon Radioisotopes; D013256:Steroids
keywords: Horner-Wadsworth-Emmons (HWE); carbon-14; olefination; steroid