title: Role of nitric oxide and mechanisms involved in cerebral injury after subarachnoid hemorrhage: is nitric oxide a possible answer to cerebral vasospasm?
abstract: Cerebral vasospasm represents the most critical event that could occur after subarachnoid hemorrhage (SAH). Therapy is only partially effective because cerebral arterial constriction is not fully understood yet. One of the most important biological messenger associated to SAH is nitric oxide (NO), that is considered local regulator of cerebral blood flow. Different nitric oxide synthase (NOS) forms play a role in different biological processes, one of which is to link neuronal activity to blood flow in cerebral cortex. We performed a reassessment of the literature to summarize the role of NO as the main inflammatory pathway activated after SAH to clarify its importance for treatment of vasospasm.
authors.affiliation: Division of Neurosurgery, Department of Neurological Sciences, University of Turin, Turin, Italy - giulia.pilloni@libero.it.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Crobeddu
authors.forename: Giulia
authors.initials: G
authors.lastname: Pilloni
authors.forename: Valentina
authors.initials: V
authors.lastname: Tardivo
authors.forename: Marco M
authors.initials: MM
authors.lastname: Fontanella
authors.forename: Pier P
authors.initials: PP
authors.lastname: Panciani
authors.forename: Giannantonio
authors.initials: G
authors.lastname: Spena
authors.forename: Riccardo
authors.initials: R
authors.lastname: Fornaro
authors.forename: Roberto
authors.initials: R
authors.lastname: Altieri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Agnoletti
authors.forename: Marco
authors.initials: M
authors.lastname: Ajello
authors.forename: Francesco
authors.initials: F
authors.lastname: Zenga
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ducati
authors.forename: Diego
authors.initials: D
authors.lastname: Garbossa
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000378:metabolism; D020301:Vasospasm, Intracranial / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase