title: The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population.
abstract: SP110 is a promising anti-Mycobacterium tuberculosis (MTB) gene. To investigate the effects of SP110 and its associated genes, i.e., MYBBP1A and RELA, on pathological progression of MTB infection, an association study with 424 patients of fresh pulmonary tuberculosis (PTB) and 424 healthy controls was performed. Moreover, classification and regression tree and multifactor dimensionality reduction were employed to explore the effects of gene-gene interactions on cavitary PTB. The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 had significant effects on the risk of PTB (OR 1.42, 95 % CI 1.06-1.92, p 0.019; OR 1.55, 95 % CI 1.04-2.33, p = 0.033, respectively), and heterozygous genotype CT in rs9061 also had similar effects (OR 1.43, 95 % CI 1.07-1.90, p = 0.014). The rs3809849 and rs9905742 in MYBBP1A were also significantly associated with cavitary PTB (p = 0.00046 and 0.039, respectively), while rs9061 in SP110 had no such association (p = 0.06931) except its significant association with non-cavitary PTB (p = 0.0093). The interaction of MYBBP1A and RELA had significant effect on cavitary PTB (OR 4.24, 95 % CI 1.44-12.49, p = 0.005). These suggest that MYBBP1A instead of SP110 may be a genetic risk factor for cavitary PTB and play important effects on its whole progress.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 55 Guangyuanxi Road, Shanghai, 200030, China.|Department of Laboratory Medicine, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, 10 Changjiangzhilu, Daping, Chongqing, 400022, China.
authors.forename: Shi-Yao
authors.initials: SY
authors.lastname: Jiang
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu, 241000, AnHui, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Mycobacterium Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Infectious Diseases, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Chen
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu, 241000, AnHui, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 55 Guangyuanxi Road, Shanghai, 200030, China.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Wan
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 55 Guangyuanxi Road, Shanghai, 200030, China.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 55 Guangyuanxi Road, Shanghai, 200030, China. cailei2010@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Laboratory Medicine, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, 10 Changjiangzhilu, Daping, Chongqing, 400022, China. shaoli.deng@yahoo.com.
authors.forename: Shao-Li
authors.initials: SL
authors.lastname: Deng
mesh_terms: D000328:Adult; D002681:China; D004268:DNA-Binding Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D009687:Nuclear Proteins / Q000235:genetics*; D029543:Nucleocytoplasmic Transport Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins; D051996:Transcription Factor RelA / Q000235:genetics*; D014157:Transcription Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C491719:MYBBP1A protein, human; D015778:Minor Histocompatibility Antigens; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; C498143:RELA protein, human; D016601:RNA-Binding Proteins; C412425:Sp110 protein, human; D051996:Transcription Factor RelA; D014157:Transcription Factors
keywords: CART; MDR; MYBBP1A; SP110; Tuberculosis