title: Cardioprotective Effects of Total Flavonoids Extracted from Xinjiang Sprig Rosa rugosa against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart.
abstract: This study evaluated the antioxidative and cardioprotective effects of total flavonoids extracted from Xinjiang sprig Rosa rugosa on ischemia/reperfusion (I/R) injury using an isolated Langendorff rat heart model. The possible mechanism of Xinjiang sprig rose total flavonoid (XSRTF) against I/R injury was also studied. XSRTF (5, 10, and 20 µg/mL) dissolved in Krebs-Henseleit buffer was administered to isolated rat heart. The XSRTF showed remarkable scavenging effects against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, and superoxide anion radicals in vitro. XSRTF pretreatment improved the heart rate, increased LVDP, and decreased CK and LDH levels in coronary flow. This pretreatment also increased SOD activity and GSH/GSSG ratio but decreased MDA, TNF-α, and CRP levels and IL-8 and IL-6 activities. The infarct size and cell apoptosis in the hearts from the XSRTF-treated group were lower than those in the hearts from the I/R group. Therefore, the cardioprotective effects of XSRTF may be attributed to its antioxidant, antiapoptotic, and anti-inflammatory activities.
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Hou
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Han
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Yuan
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Ren
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Xu
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China. zqsyt@sohu.com.
authors.forename: Qiusheng
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Pharmacy School, Shihezi University, Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi, 832002, China. chen-wen2000@126.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009203:Myocardial Infarction / Q000473:pathology / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000139:chemically induced / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027826:Rosa / Q000737:chemistry*
chemical_list: D002316:Cardiotonic Agents; D016207:Cytokines; D005419:Flavonoids; D016166:Free Radical Scavengers; D010936:Plant Extracts
keywords: Anti-inflammatory; Antiapoptotic; Antioxidant; Cardioprotective activity; Ischemia/reperfusion; Total flavonoid; Xinjiang sprig Rosa rugosa