title: The sensitivity to change over time of the Amsterdam IADL Questionnaire(©).
abstract: BACKGROUND
  This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire(©) (A-IADL-Q).
  
  
  METHODS
  Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures.
  
  
  RESULTS
  We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028).
  
  
  CONCLUSIONS
  Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.
authors.affiliation: Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Naomi
authors.initials: N
authors.lastname: Koster
authors.affiliation: Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Knol
authors.affiliation: Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Bernard M J
authors.initials: BM
authors.lastname: Uitdehaag
authors.affiliation: Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: s.sikkes@vumc.nl.
authors.forename: Sietske A M
authors.initials: SA
authors.lastname: Sikkes
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003071:Cognition; D003704:Dementia / Q000175:diagnosis / Q000503:physiopathology*; D018450:Disease Progression; D056344:Executive Function; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
keywords: Alzheimer's disease; Dementia; Instrumental activities of daily living; Mild cognitive impairment; Responsiveness; Subjective cognitive decline