title: Toxoplasma secretory granules: one population or more?
abstract: In Toxoplasma gondii, dense granules are known as the storage secretory organelles of the so-called GRA proteins (for dense granule proteins), which are destined to the parasitophorous vacuole (PV) and the PV-derived cyst wall. Recently, newly annotated GRA proteins targeted to the host cell nucleus have enlarged this view. Here we provide an update on the latest developments on the Toxoplasma secreted proteins, which to date have been mainly studied at both the tachyzoite and bradyzoite stages, and we point out that recent discoveries could open the issue of a possible, yet uncharacterized, distinct secretory pathway in Toxoplasma.
authors.affiliation: Laboratoire Adaptation et Pathogénie des Microorganismes (LAPM), CNRS UMR 5163 - Université Joseph Fourier, Grenoble, France. Electronic address: corinne.mercier@gmail.com.
authors.forename: Corinne
authors.initials: C
authors.lastname: Mercier
authors.affiliation: Laboratoire Adaptation et Pathogénie des Microorganismes (LAPM), CNRS UMR 5163 - Université Joseph Fourier, Grenoble, France. Electronic address: marie-france.cesbron@ujf-grenoble.fr.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Cesbron-Delauw
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism*
chemical_list: D015800:Protozoan Proteins
keywords: GRA proteins; Toxoplasma gondii; dense granules; protozoa