title: Thrombospondins and synaptogenesis.
abstract: Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability. Thrombospondin regulates synaptogenesis through receptor α2δ-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells. It also participates in synaptic remodeling following injury and in the action of some nervous system drugs.
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China.
authors.forename: Weitao
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
keywords: Notch; extracellular matrix; glial cell; neural progenitor cells; neural regeneration; opioid; regeneration; synapse; synaptogenesis; thrombospondin; α2δ-1