title: Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT.
abstract: OBJECTIVE
  We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT).
  
  
  METHODS
  Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively.
  
  
  RESULTS
  The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage.
  
  
  CONCLUSIONS
  The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography.
  
  
  CONCLUSIONS
  The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies.
authors.affiliation: Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands ; The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
authors.forename: Elsbeth J T
authors.initials: EJ
authors.lastname: van Zeeburg
authors.affiliation: Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands.
authors.forename: Boy
authors.initials: B
authors.lastname: Braaf
authors.affiliation: The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
authors.forename: Matteo G
authors.initials: MG
authors.lastname: Cereda
authors.affiliation: The Rotterdam Eye Hospital, Rotterdam, The Netherlands ; Erasmus University Rotterdam, Department of Ophthalmology, Rotterdam, The Netherlands.
authors.forename: Jan C
authors.initials: JC
authors.lastname: van Meurs
authors.affiliation: Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands ; LaserLaB, Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: de Boer
keywords: RPE-choroid graft; SD-OCT; phase-resolved doppler OCT