title: Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion?
abstract: The mammalian blastocyst exhibits a high capacity for aerobic glycolysis, a metabolic characteristic of tumours. It has been considered that aerobic glycolysis is a means to ensure a high carbon flux to fulfil biosynthetic demands. Here, alternative explanations for this pattern of metabolism are considered. Lactate creates a microenvironment of low pH around the embryo to assist the disaggregation of uterine tissues to facilitate trophoblast invasion. Further it is proposed that lactate acts as a signalling molecule (especially at the reduced oxygen tension present at implantation) to elicit bioactive VEGF recruitment from uterine cells, to promote angiogenesis. Finally it is suggested that the region of high lactate/low pH created by the blastocyst modulates the activity of the local immune response, helping to create immune tolerance. Consequently, the mammalian blastocyst offers a model to study the role of microenvironments, and how metabolites and pH are used in signalling.
authors.affiliation: School of BioSciences, University of Melbourne, Melbourne, Australia.
authors.forename: David K
authors.initials: DK
authors.lastname: Gardner
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000378:metabolism; D010064:Embryo Implantation / Q000502:physiology; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008322:Mammals; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D019344:Lactic Acid
keywords: implantation; lactate; microenvironment; signalling