title: Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.
abstract: BACKGROUND
  Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Hydrogen sulfide (H2S) plays an important role in physiology and pathophysiology of liver. However, whether exogenous H2S could mitigate the hepatic steatosis in mice remains unclear. The aim of this study is to evaluate the effects of H2S on fatty liver.
  
  
  METHODS
  C57BL/6 mice were fed with either a high-fat diet (HFD) or a normal fat diet (NFD) for 16 weeks. After 12 weeks of feeding, the HFD-fed mice were injected one time per day with NaHS or saline for the followed 4 weeks.
  
  
  RESULTS
  Compared to NFD, HFD could induce an accumulation of lipids in liver and a damage of hepatic structure. Compared to saline treatment, in the liver of HFD fed mice H2S treatment could significantly (1) recover the structure; (2) decrease the accumulation of lipids including triglyceride (TG) and total cholesterol (TC); (3) decrease the expression of fatty acid synthase (FAS) and increase the expression of carnitine palmitoyltransferase-1 (CPT-1); (4) reduce malondialdehyde (MDA) levels; (5) increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx).
  
  
  CONCLUSIONS
  H2S could mitigate the fatty liver by improving lipid metabolism and antioxidant potential in HFD-induced obese mice.
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Institute of Environmental Medicine of Henan University, Kaifeng, 475004 China.|Nursing College of Henan University, Kaifeng, 475004 China.
authors.forename: Nairui
authors.initials: N
authors.lastname: Zheng
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Institute of Neurological Disorder, Henan University, Kaifeng, 475004 China.
authors.forename: Kunqing
authors.initials: K
authors.lastname: Qi
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Biao
authors.initials: B
authors.lastname: Gao
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Youjing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Huaihe Hospital of Henan University, Kaifeng, 475004 China.
authors.forename: Wuyan
authors.initials: W
authors.lastname: Pang
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.|Institute of Environmental Medicine of Henan University, Kaifeng, 475004 China.
authors.forename: Chaoshen
authors.initials: C
authors.lastname: Huangfu
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Ji
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Institute of Neurological Disorder, Henan University, Kaifeng, 475004 China.
authors.forename: Mengzhou
authors.initials: M
authors.lastname: Xue
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Ji
authors.affiliation: Medical College of Henan University, Kaifeng, 475004 Henan China.
authors.forename: Yanzhang
authors.initials: Y
authors.lastname: Li
keywords: Antioxidant; Fatty liver; Hydrogen sulfide; Lipid metabolism; Mitigation