title: Targeting extrinsic apoptosis in cancer: Challenges and opportunities.
abstract: Apoptosis is a form of programmed cell death that plays a critical role in the regulation of various physiological and pathophysiological processes. Since apoptosis is typically disturbed in human cancers, therapeutic targeting of apoptosis represents a promising avenue for the development of novel therapeutic approaches. This strategy is particularly relevant, since many currently used anticancer therapies utilize apoptosis signaling pathways to exert their antitumor activities. A better understanding of these signaling networks and their deregulation in human cancers is anticipated to open new perspectives for the development of apoptosis-targeted therapies for the treatment of cancer.
authors.affiliation: Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstr. 3a, 60528 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: simone.fulda@kgu.de.
authors.forename: Simone
authors.initials: S
authors.lastname: Fulda
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D053218:Receptors, Death Domain / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000037:antagonists & inhibitors
chemical_list: D053218:Receptors, Death Domain; D053221:TNF-Related Apoptosis-Inducing Ligand
keywords: Apoptosis; Cancer; Caspase-8; TRAIL