title: A new lignan with hypoglycemic activity from Tadehagi triquetrum.
abstract: A new lignan named tadehaginosin, together with a known compound 3,4-dihydro-4-(4'-hydroxyphenyl)-5,7-dihydroxycoumarin, was isolated from the aerial part of Tadehagi triquetrum. The new structure was determined by various spectroscopic techniques ((1)H and (13)C APT, HSQC, HMBC, (1)H-(1)HCOSY, NOESY and HR-ESI-MS). The two isolates were evaluated for their hypoglycemic effects in vitro. Biological investigation showed that both of them possessed the capability to increase glucose consumption by HepG2 cells.
authors.affiliation: a School of Pharmaceutical Science, Hainan Medical University , Haikou 571101 , P.R. China.
authors.forename: Jiani
authors.initials: J
authors.lastname: Wu
authors.forename: Cai yun
authors.initials: Cy
authors.lastname: Zhang
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Ni
authors.initials: N
authors.lastname: An
authors.forename: Youbin
authors.initials: Y
authors.lastname: Li
authors.forename: Nailiang
authors.initials: N
authors.lastname: Zhu
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
mesh_terms: D007887:Fabaceae / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D007004:Hypoglycemic Agents; D017705:Lignans; C000602382:tadehaginosin
keywords: Tadehagi triquetrum; hypoglycemic effects; tadehaginosin