title: [Hypogonadotropic hypogonadism in Klinefelter syndrome and hypothalamic-pituitary tumor].
abstract: Klinefelter Syndrome is the most frequent cause of hypergonadotropic hypogonadism in men. A flat response at luteinizing hormone releasing hormone stimulation test could be the first sign of hypothalamic tumor in these patients. We report the case of a patient diagnosed by neonatal screening with Klinefelter Syndrome, 47 XXY, that at 17 years follow-up presents analytical modification of the response to luteinizing hormone releasing hormone stimulation test with suppressed luteinizing hormone and follicle-stimulating hormone values; lately he presents with headache and loss of left eye vision. A magnetic resonance imaging of the brain showed a mixed germ cell hypothalamus tumor, requiring surgery, chemotherapy and radiotherapy with optimal response.
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Anunciación
authors.initials: A
authors.lastname: Beisti Ortego
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: De Arriba Muñoz
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Ferrer Lozano
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Martínez de Zabarte Fernández
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Carlota
authors.initials: C
authors.lastname: Calvo Escribano
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Labarta Aizpún
mesh_terms: D000293:Adolescent; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000628:therapy; D007029:Hypothalamic Neoplasms / Q000150:complications* / Q000628:therapy; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000628:therapy