title: Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.
abstract: Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.
authors.affiliation: National Center for Nanoscience and Technology, Beijing, 100190, China.|Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Hou
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Jin-sil
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Kuan-Ju
authors.initials: KJ
authors.lastname: Chen
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.|School of Biomedical Engineering, MED-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Mitch A
authors.initials: MA
authors.lastname: Garcia
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
authors.forename: Jue-Hua
authors.initials: JH
authors.lastname: Yu
authors.affiliation: Molecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
authors.forename: Kaushali
authors.initials: K
authors.lastname: Thakore-Shah
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Tracy
authors.initials: T
authors.lastname: Ro
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Jie-Fu
authors.initials: JF
authors.lastname: Chen
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Parham
authors.initials: P
authors.lastname: Peyda
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
authors.forename: Guoping
authors.initials: G
authors.lastname: Fan
authors.affiliation: Molecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
authors.forename: April D
authors.initials: AD
authors.lastname: Pyle
authors.affiliation: National Center for Nanoscience and Technology, Beijing, 100190, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
authors.forename: Hsian-Rong
authors.initials: HR
authors.lastname: Tseng
mesh_terms: D002460:Cell Line; D054338:Cell Transdifferentiation / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics; D000067470:Cellular Reprogramming Techniques / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D053769:Nanocapsules; D036103:Nanotechnology; D020641:Polymorphism, Single Nucleotide
chemical_list: D053769:Nanocapsules
keywords: cell reprogramming; cell transdifferentiation; nanoparticles; nanosubstrates, gene delivery; supramolecular chemistry