title: Extensively drug-resistant Acinetobacter baumannii belonging to the international clonal lineage I in a Russian burn intensive care unit.
abstract: The high incidence of mortality in patients with severe burns can be attributed to bloodstream infections caused by drug-resistant microorganisms. Multilocus variable-number tandem repeat analysis (MLVA), multilocus sequence typing (MLST) and class 1 integron PCR amplification were performed to investigate an extensively drug-resistant Acinetobacter baumannii (XDR-AB) strain recovered from a blood culture of a patient admitted to a burn intensive care unit in St Petersburg (Russian Federation). This case study describes an XDR-AB strain of multilocus sequence type ST231 with a blaGES-12 gene cassette encoding a very potent ceftazidimase located inside of a composite class 1 integron. This is the first documented case of XDR-AB belonging to the international clonal lineage I in Russia.
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russian Federation. Electronic address: solomen@iegm.ru.
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Solomennyi
authors.affiliation: I.I. Mechnikov North-Western State Medical University, St Petersburg, Russian Federation.
authors.forename: Artemiy
authors.initials: A
authors.lastname: Goncharov
authors.affiliation: I.I. Mechnikov North-Western State Medical University, St Petersburg, Russian Federation.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Zueva
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002053:Burn Units; D002056:Burns / Q000150:complications*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D032023:Integrons; D007362:Intensive Care Units; D018598:Minisatellite Repeats; D058885:Multilocus Sequence Typing; D016133:Polymerase Chain Reaction; D012426:Russia
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial
keywords: Acinetobacter baumannii; Antimicrobial resistance; Bacterial infections; Burn intensive care unit; Class 1 integron; Molecular surveillance