title: Effects of food intake on pharmacokinetics of mosapride in beagle dogs.
abstract: This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5-mg oral dose of mosapride was administered to fasted (n = 15) and fed (n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography-tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis (NCA). Mosapride was absorbed in fasted and fed dogs with similar Tmax . Both Cmax and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/mL vs. 2.76 μg/mL) and 3.5 times higher (38.53 h · μg/mL vs. 10.22 h · μg/mL), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Chae
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: B-J
authors.initials: BJ
authors.lastname: Song
authors.affiliation: College of Pharmacy, Kyungsung University, Busan, Korea.
authors.forename: I-H
authors.initials: IH
authors.lastname: Baek
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Yun
authors.affiliation: Korean Medicine (KM)-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: K-I
authors.initials: KI
authors.lastname: Kwon
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs / Q000378:metabolism; D004435:Eating / Q000502:physiology; D005215:Fasting / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; C062720:mosapride