title: Facile syntheses of functionalized toll-like receptor 7 agonists.
abstract: Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.
authors.affiliation: Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
authors.forename: Babatope
authors.initials: B
authors.lastname: Akinbobuyi
authors.affiliation: Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Byrd
authors.affiliation: Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Chang
authors.affiliation: Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
authors.forename: Mysa
authors.initials: M
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
authors.forename: Zacharie J
authors.initials: ZJ
authors.lastname: Seifert
authors.affiliation: Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Flamar
authors.affiliation: Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
authors.forename: Gerard
authors.initials: G
authors.lastname: Zurawski
authors.affiliation: Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA.
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Upchurch
authors.affiliation: Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
authors.forename: SangKon
authors.initials: S
authors.lastname: Oh
authors.affiliation: Department of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Dempsey
authors.affiliation: Department of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Enke
authors.affiliation: Department of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
authors.forename: John
authors.initials: J
authors.lastname: Le
authors.affiliation: Department of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
authors.forename: Hunter J
authors.initials: HJ
authors.lastname: Winstead
authors.affiliation: Department of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
authors.forename: José R
authors.initials: JR
authors.lastname: Boquín
authors.affiliation: Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA ; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Kane
keywords: Adenine derivatives; Immune activation; Toll-like receptor; Vaccines