title: Calcifications in benfluorex-induced valve heart disease: a misknown association.
abstract: Benfluorex, an anorexigenic agent, is recognized to induce noncalcified restrictive valvular regurgitation. We report a well-documented case of a 73-year-old patient who developed heart failure with aortic and mitral regurgitation following benfluorex intake. Echocardiography and peroperative analysis found large mitral annular calcifications and aortic subvalvular calcifications. Pathology confirmed drug-induced valve heart disease (DIVHD). The presence of valvular apparatus calcification should not lead to diagnosis of degenerative valvular disease and a priori preclude the diagnosis of DIVHD.
authors.affiliation: Cardiology Department, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
authors.forename: François
authors.initials: F
authors.lastname: Plurien
authors.forename: Patrick
authors.initials: P
authors.lastname: Bruneval
authors.forename: Yannick
authors.initials: Y
authors.lastname: Jobic
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Pierre-Vladimir
authors.initials: PV
authors.lastname: Ennezat
mesh_terms: D000368:Aged; D001022:Aortic Valve Insufficiency / Q000473:pathology; D001067:Appetite Depressants / Q000009:adverse effects*; D002114:Calcinosis / Q000139:chemically induced*; D005277:Fenfluramine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006349:Heart Valve Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000473:pathology
chemical_list: D001067:Appetite Depressants; D005277:Fenfluramine; C001584:benfluorex