title: The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China.
abstract: We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China.
authors.affiliation: Department of Infectious Diseases, Institute of Infectious and Respiratory Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China.
authors.forename: Dao
authors.initials: D
authors.lastname: Huang
authors.forename: Marie
authors.initials: M
authors.lastname: Hennequi
authors.forename: Alexei
authors.initials: A
authors.lastname: Elvachev
authors.forename: Thierry
authors.initials: T
authors.lastname: Menguy
authors.forename: Nathalie
authors.initials: N
authors.lastname: Silvestre
authors.forename: DeMin
authors.initials: D
authors.lastname: Yu
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
authors.forename: Geneviève
authors.initials: G
authors.lastname: Inchauspé
authors.forename: Xinxin
authors.initials: X
authors.lastname: Zhang
authors.forename: Ren
authors.initials: R
authors.lastname: Zhu
mesh_terms: D000257:Adenoviridae Infections / Q000097:blood* / Q000453:epidemiology; D000260:Adenoviruses, Human / Q000276:immunology*; D000328:Adult; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002353:Carrier State / Q000097:blood*; D002681:China / Q000453:epidemiology; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral