title: HER2/neu negative salivary duct carcinoma of parotid: A case with forty months recurrence free follow up.
abstract: BACKGROUND
  Salivary duct carcinoma (SDC) is very rare, only 1-3% of all salivary gland tumors are reported as SDC. SDC predominantly occurs in elderly males, SCD is characterized by an aggressive clinical course of the disease with less than 60% five years survival from the day of initial diagnosis, lymph node metastasis and facial nerve involvement is common, the current literature lacks protocol regarding management of this entity and the advantage of adjuvant therapy has not been evaluated due to its rare occurrence.
  
  
  METHODS
  We report patient with stage IV HER2/neu negative SDC successfully treated with surgery followed by adjuvant radiotherapy, patient is followed up for 40 months without evidence of recurrence or metastasis.
  
  
  CONCLUSIONS
  SDC is reported to be similar to mammary duct carcinoma in clinical and immunohistologic typing, further it shows an association of expression of HER-2/neu and p53, with early local disease recurrence, distant metastasis and survival, however; current case was adequately followed up and reevaluated after 26 months, MRI did not show evidence of recurrence.
  
  
  CONCLUSIONS
  SDC is a rare tumor and information on association of HER2/neu with survival is useful in further research on this tumor.
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh 500034, India. Electronic address: sandhyagokavarapu@gmail.com.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Gokavarapu
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh 500034, India. Electronic address: daf_doc_2005@hotmail.com.
authors.forename: Daphne
authors.initials: D
authors.lastname: Fonseca
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh 500034, India. Electronic address: drsreenivasms@yahoo.co.in.
authors.forename: Sreenivasa
authors.initials: S
authors.lastname: Puthamakula
authors.affiliation: Government Dental College and Hospital, Hyderabad, Andhra Pradesh 500034, India. Electronic address: drpbalreddy@yahoo.co.in.
authors.forename: Bal P
authors.initials: BP
authors.lastname: Reddy
authors.affiliation: Government Dental College and Hospital, Hyderabad, Andhra Pradesh 500034, India. Electronic address: drsridharb@gmail.com.
authors.forename: B Sridhar
authors.initials: BS
authors.lastname: Reddy
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh 500034, India. Electronic address: sumurthy@gmail.com.
authors.forename: Sudha
authors.initials: S
authors.lastname: Murthy
keywords: HER2/neu negative; Parotid; Salivary duct carcinoma