title: Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes.
abstract: The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye. Upon NIR laser irradiation at 808 nm, ICG in the liposomes containing ICG and Ce6 could be degraded, while the phototoxicity of Ce6 could be recovered. In addition, we demonstrate that this newly developed liposomal component can be successfully used for activatable PDT to destroy cancer cells in vitro.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China. wuj@nju.edu.cn huyiqiao@nju.edu.cn.
authors.forename: Ahu
authors.initials: A
authors.lastname: Yuan
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Tang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Qiu
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wu
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002735:Chlorophyllides; D004396:Coloring Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D007208:Indocyanine Green / Q000008:administration & dosage / Q000494:pharmacology; D007259:Infrared Rays; D008081:Liposomes; D009369:Neoplasms / Q000473:pathology*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D011166:Porphyrins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D002735:Chlorophyllides; D004396:Coloring Agents; D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D007208:Indocyanine Green