title: Advances in cellular technology in the hematology field: What have we learned so far?
abstract: Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Gustavo Torres
authors.initials: GT
authors.lastname: de Souza
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Claudinéia Pereira
authors.initials: CP
authors.lastname: Maranduba
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Camila Maurmann
authors.initials: CM
authors.lastname: de Souza
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Danielle Luciana Aurora Soares
authors.initials: DL
authors.lastname: do Amaral
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Francisco Carlos
authors.initials: FC
authors.lastname: da Guia
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Rafaella de Souza Salomão
authors.initials: Rde S
authors.lastname: Zanette
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: João Vitor Paes
authors.initials: JV
authors.lastname: Rettore
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Natana Chaves
authors.initials: NC
authors.lastname: Rabelo
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Lucas Mendes
authors.initials: LM
authors.lastname: Nascimento
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Ícaro França Navarro
authors.initials: ÍF
authors.lastname: Pinto
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Júlia Boechat
authors.initials: JB
authors.lastname: Farani
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Abrahão Elias Hallack
authors.initials: AE
authors.lastname: Neto
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Fernando de Sá
authors.initials: Fde S
authors.lastname: Silva
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Carlos Magno da Costa
authors.initials: CM
authors.lastname: Maranduba
authors.affiliation: Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.
authors.forename: Angelo
authors.initials: A
authors.lastname: Atalla
keywords: Embryonic stem cells; Hematopoietic stem cells; Induced pluripotent stem cells; Progenitor; Reprogramming