title: Fentanyl-induced asystole in two dogs.
abstract: Fentanyl is used in small animals for perioperative analgesia during anaesthesia. Severe bradycardia and asystole were observed on bolus administration of a 3 µg/kg loading dose of fentanyl in two dogs under isoflurane anaesthesia. Premedication with 10 µg/kg glycopyrrolate did not prevent asystole in the first case; and although bradycardia was treated with 5 µg/kg glycopyrrolate administered intravenously in the second case, the heart rate continuously decreased and asystole subsequently developed. Asystole in both cases was quickly corrected by intravenous administration of 0 · 04 mg/kg atropine and closed chest compressions. This case report describes asystole induced by fentanyl administration in isoflurane anaesthetised dogs. Atropine was more effective than glycopyrrolate in the treatment of fentanyl-induced asystole.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: M
authors.initials: M
authors.lastname: Jang
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: W-G
authors.initials: WG
authors.lastname: Son
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: I
authors.initials: I
authors.lastname: Lee
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001919:Bradycardia / Q000139:chemically induced / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006339:Heart Rate; D007262:Infusions, Intravenous / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D010027:Osteotomy / Q000379:methods / Q000662:veterinary
chemical_list: D000701:Analgesics, Opioid; D007530:Isoflurane; D005283:Fentanyl