title: Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37.
abstract: Five cases of bacterial meningitis treated with ceftaroline (4 Streptococcus pneumoniae and 1 Staphylococcus aureus) are summarized here. The pharmacodynamics of human cathelicidin LL-37 and ceftaroline were evaluated against S. pneumoniae. Patients who received ceftaroline 600 mg every 8 h (q8h) (1 S. aureus and 3 S. pneumoniae) were successfully treated; treatment failed in 1 patient with S. pneumoniae who received 600 mg q12h. Ceftaroline increased the negative surface charge and sensitized S. pneumoniae to killing by LL-37, a peptide implicated in blood-brain barrier defense.
authors.affiliation: Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA gsakoulas@ucsd.edu.
authors.forename: George
authors.initials: G
authors.lastname: Sakoulas
authors.affiliation: Department of Biological Sciences, University of California San Diego, La Jolla, California, USA.
authors.forename: Poochit
authors.initials: P
authors.lastname: Nonejuie
authors.affiliation: College of Pharmacy, Oregon State University/Oregon Health Sciences University, Portland, Oregon, USA.
authors.forename: Ravina
authors.initials: R
authors.lastname: Kullar
authors.affiliation: Department of Biological Sciences, University of California San Diego, La Jolla, California, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Pogliano
authors.affiliation: Eugene Applebaum College of Pharmacy and Health Sciences, School of Medicine, Wayne State University, Detroit, Michigan, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rybak
authors.affiliation: Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Nizet
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D045304:Cytochromes c / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016019:Survival Analysis; D054804:Cathelicidins; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002511:Cephalosporins; D045304:Cytochromes c; D054804:Cathelicidins; D000097583:Ceftaroline