title: Looking into the "Garden of the Hesperides": new drugs for hepatocellular carcinoma.
abstract: Advanced hepatocellular carcinoma remains an entity that is hard to approach therapeutically and has shown disappointing results in terms of survival. For many years, the only accepted option for this setting was the use of a multikinase inhibitor, sorafenib. Nevertheless, through the years, a deeper knowledge has arisen about how pathogenic pathways correlate with hepatocellular carcinoma. In this review, we provide an update of the most recent data regarding new agents under investigation and new possible targets for future treatments.
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra Pamplona, Spain - christian.rolfo@uza.be.
authors.forename: E
authors.initials: E
authors.lastname: Castañón Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Giallombardo
authors.forename: I
authors.initials: I
authors.lastname: Gil-Bazo
authors.forename: K
authors.initials: K
authors.lastname: Papadimitriou
authors.forename: P
authors.initials: P
authors.lastname: Pauwels
authors.forename: M
authors.initials: M
authors.lastname: Peeters
authors.forename: C
authors.initials: C
authors.lastname: Rolfo
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D000076222:Mechanistic Target of Rapamycin Complex 1; D019365:Metaphor; D046912:Multiprotein Complexes / Q000494:pharmacology / Q000627:therapeutic use*; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors*; D058570:TOR Serine-Threonine Kinases / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D046912:Multiprotein Complexes; D019859:Proto-Oncogene Proteins c-met; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases