title: [Severe hyponatremia during chemotherapy for small cell carcinoma].
abstract: BACKGROUND
  The small cell lung cancer (SCLC) is a rapidly progressive malignancy with a poor prognosis. Its chemosensitivity mandates prompt treatment. Hyponatremia occurs frequently in patients with small cell lung cancer due to the syndrome of inappropriate antidiuretic hormone (SIADH). We report a case of severe hyponatremia induced by chemotherapy that required management in intensive care.
  
  
  METHODS
  A 68-year-old patient was undergoing treatment for small cell cancer, invading the right lung. On the second day of the first cycle of treatment (cisplatine-vepeside), the patient became comatose and required transfer to an intensive care unit. The coma was due to severe hyponatremia (107 mmol/L) and improved with specific treatment. The patient had similar episodes on the second day of each chemotherapy treatment but with less and less severe clinical manifestations. Hyponatremia due to chemotherapy in SCLC is not commonly known; a relation between hyponatremia intensity and the tumor size is suspected.
  
  
  CONCLUSIONS
  This clinical case highlights the possibility of severe hyponatremia during small cell lung cancer chemotherapy. Hyponatremia may be related to the reduction in tumor size. Monitoring of electrolytes on day 2 of chemotherapy is advised.
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Garoute
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Plouvier
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Iacob
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Cotrel
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Suguenot
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Lecuyer
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Bentayeb
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Douadi
authors.affiliation: Service de pneumologie - maladies infectieuses et tropicales, centre hospitalier de Saint-Quentin, 1, avenue Miche-de -l'Hospital, BP 608, 02321 Saint-Quentin cedex, France. Electronic address: dayen.charles@live.fr.
authors.forename: C
authors.initials: C
authors.lastname: Dayen
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003128:Coma / Q000209:etiology; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D005047:Etoposide; D002945:Cisplatin
keywords: Cancer bronchique à petites cellules; Chemotherapy; Chimiothérapie; Hyponatremia; Hyponatrémie; Small cell lung cancer; Syndrome de sécrétion inappropriée d’hormone antidiurétique; Syndrome of inappropriate antidiuretic hormone secretion