title: Early growth response-1 (EGR-1) - a key player in myocardial cell injury.
abstract: Coronary heart disease is the leading cause of mortality worldwide, affecting millions of men and women every year. Elucidation of key signaling factors and their pathways are critical for understanding and developing novel therapeutic targets for protection of the myocardium from ischemia. EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes. This article reviews the growing evidence implicating EGR-1 pathway in myocardial ischemia/reperfusion, cardiac hypertrophy and other cardiovascular complications like atherosclerosis.
authors.forename: Nirupama
authors.initials: N
authors.lastname: Ramadas
authors.forename: Barathi
authors.initials: B
authors.lastname: Rajaraman
authors.forename: Ashok A
authors.initials: AA
authors.lastname: Kuppuswamy
authors.affiliation: Department of Biotechnology, School of Chemical and Biotechnology, Anusandhan Kendra#208, SASTRA University, Thanjavur-613401, India. srinivasan@scbt.sastra.edu.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vedantham
mesh_terms: D051766:Early Growth Response Protein 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*
chemical_list: D051766:Early Growth Response Protein 1