title: Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post-menopausal women.
abstract: Osteoporosis represents a serious health problem worldwide associated with an increased risk of fractures and mortality. Nutrition should form part of bone disease prevention strategies, especially in the light of the population ageing and the diet effect on bone health. Thus the study aimed at verifying whether 1 year of oral supplementation with either extra virgin olive oil (VOO) enriched with vitamins D3, K1 and B6 (VitVOO) or VOO used as placebo (PlaVOO) is able to modify some bone turnover and oxidative stress markers. Bone mineral density (BMD) was assessed in 60 healthy post-menopausal women together with the bone vitamin K status by measuring undercarboxylated osteocalcine (ucOC) plasma levels, the ratio between ucOC and carboxylated osteocalcine (UCR) and the relations with oxidative stress markers. After 1 year (T 1), subjects taking VitVOO showed lower ucOC levels than those taking PlaVOO; the same trend was found for UCR. As far as BMD is concerned, a significant increase in T-score at T 1 in VitVOO subjects compared to PlaVOO was found. All oxidative stress markers as thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes showed a significant reduction after VitVOO supplementation, whilst plasma total antioxidant capacity values was significantly increased in VitVOO group compared to PlaVOO group at T 1. It might be suggested that the use of VitVOO in the diet of post-menopausal women could represent a proper tool for bone protection and a useful strategy against oxidative stress and related diseases, thus confirming the antioxidant role played by the added vitamins.
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy. lauramazzanti48@gmail.com.|Section of Biochemistry, Department of Clinical Science, School of Medicine, Università Politecnica delle Marche, Via Ranieri 65, 60127, Ancona, Italy. lauramazzanti48@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzanti
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Nanetti
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Raffaelli
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alidori
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Sforza
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Università Politecnica delle Marche, Via Tronto 10 A, 60100, Ancona, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Carle
authors.affiliation: Department of Obstetrics, Gynecology and Pediatrics, Senigallia Hospital - ASL, 4 - Via Cellini 1, 60019, Senigallia, Ancona, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Quagliarini
authors.affiliation: Department of Obstetrics, Gynecology and Pediatrics, Senigallia Hospital - ASL, 4 - Via Cellini 1, 60019, Senigallia, Ancona, Italy.
authors.forename: Nelvio
authors.initials: N
authors.lastname: Cester
authors.affiliation: Section of Biochemistry, Biology and Physics, Department of Clinical Sciences, School of Nutrition, Università Politecnica delle Marche, Via Ranieri 65, 60131, Ancona, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Vignini
mesh_terms: D015519:Bone Density / Q000187:drug effects*; D002762:Cholecalciferol / Q000008:administration & dosage / Q000494:pharmacology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D000069463:Olive Oil / Q000008:administration & dosage / Q000494:pharmacology*; D017063:Outcome Assessment, Health Care; D018384:Oxidative Stress / Q000187:drug effects*; D017698:Postmenopause / Q000097:blood* / Q000187:drug effects*; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000494:pharmacology; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000494:pharmacology; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000069463:Olive Oil; D014815:Vitamins; D002762:Cholecalciferol; D025101:Vitamin B 6; D010837:Vitamin K 1
keywords: Bone mineral density; Osteocalcin; Osteoporosis; Oxidative stress; Vitaminized oil