title: [Identification of proliferating cells in Taenia solium cysts].
abstract: Neoblasts are totipotent cells, solely responsible for the proliferation and maturation of tissues in free-living flatworms. Similar cells have been isolated from parasitic flatworms such as Echinococcus. Taenia solium causes human taeniasis (intestinal) and cysticercosis in humans and pigs. Brain infection with larvae (cysts) of T. solium results in neurocysticercosis which is hyperendemic in Peru, and its treatment is associated with serious neurological symptoms. The proliferative capacity and development stages of T. solium have not been described and the neoblasts of this parasite have not been characterized We looked for cell proliferation in T. solium cysts collected from an infected pig, which were identified when replicating and incorporating bromodeoxyuridine nucleotide detected with a monoclonal antibody. A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium.
authors.affiliation: Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Orrego-Solano
authors.affiliation: Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Carla
authors.initials: C
authors.lastname: Cangalaya
authors.affiliation: Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Nash
authors.affiliation: Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Cristina
authors.initials: C
authors.lastname: Guerra-Giraldez
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003552:Cysticercus / Q000166:cytology*; D041201:Taenia solium / Q000166:cytology*