title: Hypomethylation of MAOA's first exon region in depression: a replication study.
abstract: We recently showed that depression in females is associated with hypomethylation in the first exon region of the monoamine oxidase A (MAOA) gene. Here we report on a small-scale (n=44) replication study of MAOA methylation which (a) confirms that female subjects with a history of depression are hypomethylated compared to controls and (b) shows that females are hypermethylated in the same region compared to males.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, CMM L8:00, Karolinska University Hospital, 17176 Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address: Philippe.Melas@ki.se.
authors.forename: Philippe A
authors.initials: PA
authors.lastname: Melas
authors.affiliation: Department of Public Health Sciences, Public Health Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Forsell
mesh_terms: D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D019175:DNA Methylation / Q000235:genetics*; D003863:Depression / Q000235:genetics* / Q000523:psychology; D003866:Depressive Disorder / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012044:Regression Analysis; D012727:Sex Characteristics
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: DNA methylation; Epigenetics; Monoamine oxidase A