title: Interaction between VWF and FVIII in treating VWD.
abstract: In patients with von Willebrand disease (VWD), the absence of von Willebrand factor (VWF) antigen leads to the premature loss of endogenous circulating secreted factor VIII (FVIII), thereby resulting in the dual defect in haemostasis. Consequently, correcting the VWF deficiency also acts to correct the associated defect in FVIII activity because exogenous VWF forms complexes with and protects endogenous FVIII. The purpose of this study was to summarise relevant aspects of the interaction between VWF and FVIII and to analyse their effects on VWD treatment. Differences in the VWF/FVIII ratios in coagulation factor concentrates should be considered when treating VWD.
authors.affiliation: Medical Clinic III, Institute of Transfusion Medicine, Goethe University, Frankfurt, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Miesbach
authors.affiliation: Centre for Thrombosis and Haemostasis, Skane University Hospital, Lund University, Malmö, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Berntorp
mesh_terms: D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D014842:von Willebrand Diseases / Q000097:blood* / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D014841:von Willebrand Factor; C078147:F8 protein, human; D005169:Factor VIII
keywords: factor VIII; haemophilia A; von Willebrand disease; von Willebrand factor