title: Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease.
abstract: BACKGROUND
  Non-alcoholic fatty liver disease is the most common liver disease worldwide.
  
  
  OBJECTIVE
  The aim of this study is to compare the metabolic effects of the Mediterranean diet versus the diet associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients with non-alcoholic fatty liver disease.
  
  
  METHODS
  Thirty Caucasian overweight patients were randomized into three groups of 10 (Groups A, B and C). A personalized Mediterranean diet was started in Group A and B patients. In association with the diet, Group B patients were given Realsil complex, daily, for 6 months. Group C patients refused any treatment.
  
  
  RESULTS
  We showed that the Mediterranean diet alone, or in association with the Realsil complex, led to the significant variation in BMI, waist circumference, total cholesterol and triglycerides. We also observed a statistically significant decrease in homeostasis model assessment technique in Group B patients.
authors.affiliation: Department of Health Sciences, University "Magna Græcia", Viale Europa - Germaneto, 88100 Catanzaro, Italy.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.forename: Marta
authors.initials: M
authors.lastname: Greco
authors.forename: Immacolata
authors.initials: I
authors.lastname: Nazionale
authors.forename: Valentina
authors.initials: V
authors.lastname: Peta
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
authors.forename: Francesca
authors.initials: F
authors.lastname: Accattato
authors.forename: Daniela
authors.initials: D
authors.lastname: Foti
authors.forename: Elio
authors.initials: E
authors.lastname: Gulletta
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzza
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D038441:Diet, Mediterranean; D019587:Dietary Supplements; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy*; D050177:Overweight / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy*; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D011446:Prospective Studies; D000077385:Silybin; D012838:Silymarin / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage*; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D010713:Phosphatidylcholines; D012838:Silymarin; D014280:Triglycerides; D014810:Vitamin E; D000077385:Silybin; D002784:Cholesterol
keywords: BMI; antioxidant; insulin resistance; liver steatosis; metabolism