title: Therapeutic landscape of carfilzomib and other modulators of the ubiquitin-proteasome pathway.
authors.affiliation: Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA constantine_mitsiades@dfci.harvard.edu.
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Mitsiades
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001896:Boron Compounds / Q000494:pharmacology; D001897:Boronic Acids / Q000494:pharmacology; D000069286:Bortezomib; D045744:Cell Line, Tumor / Q000187:drug effects; D002986:Clinical Trials as Topic; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D061988:Proteasome Inhibitors / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001896:Boron Compounds; D001897:Boronic Acids; D009842:Oligopeptides; D061988:Proteasome Inhibitors; D011719:Pyrazines; D025801:Ubiquitin; D000069286:Bortezomib; C548400:ixazomib; C524865:carfilzomib; C088874:PSMB5 protein, human; D046988:Proteasome Endopeptidase Complex; D005998:Glycine