title: Mechanical systems biology of C. elegans touch sensation.
abstract: The sense of touch informs us of the physical properties of our surroundings and is a critical aspect of communication. Before touches are perceived, mechanical signals are transmitted quickly and reliably from the skin's surface to mechano-electrical transduction channels embedded within specialized sensory neurons. We are just beginning to understand how soft tissues participate in force transmission and how they are deformed. Here, we review empirical and theoretical studies of single molecules and molecular ensembles thought to be involved in mechanotransmission and apply the concepts emerging from this work to the sense of touch. We focus on the nematode Caenorhabditis elegans as a well-studied model for touch sensation in which mechanics can be studied on the molecular, cellular, and systems level. Finally, we conclude that force transmission is an emergent property of macromolecular cellular structures that mutually stabilize one another.
authors.affiliation: Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Krieg
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Dunn
authors.forename: Miriam B
authors.initials: MB
authors.lastname: Goodman
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D017173:Caenorhabditis elegans / Q000166:cytology / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular; D008870:Microtubules / Q000502:physiology; D014110:Touch
chemical_list: D029742:Caenorhabditis elegans Proteins
keywords: Caenorhabditis elegans; cytoskeleton; force transmission; mechanics; mechanosensation; tension; touch