title: Ewing sarcoma of the posterior fossa in an adolescent girl.
abstract: Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment.
authors.affiliation: Department of Neurosurgery, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 41, 24105 Kiel, Germany.
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Stark
authors.affiliation: Institute of Pathology, Children's Tumor Registry, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 14, 24105 Kiel, Germany.
authors.forename: Ivo
authors.initials: I
authors.lastname: Leuschner
authors.affiliation: Department of Neurosurgery, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 41, 24105 Kiel, Germany.
authors.forename: H Maximilian
authors.initials: HM
authors.lastname: Mehdorn
authors.affiliation: Department of Pediatrics, Schleswig-Holstein Medical University in Kiel, Arnold-Heller Strasse 3, Haus 9, 24105 Kiel, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Claviez