title: Enhancer trafficking: free throws and three-pointers.
abstract: Accurate targeting of transcriptional enhancers to the correct promoter poses a significant information problem in higher eukaryotes. Enhancer-core promoter specificity may provide one solution. Reporting recently in Nature, Zabidi et al. (2014) uncover, via a genome-wide analysis approach, two general classes of enhancer-promoter interactions differentially regulating "housekeeping" versus "developmental" genes.
authors.affiliation: Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Yiliang
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: arnosti@msu.edu.
authors.forename: David N
authors.initials: DN
authors.lastname: Arnosti
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D020043:Genes, Essential / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*