title: [Study of reconstruction of digital three-dimensional model of normal human placental vascular network based on MRI data in vitro].
abstract: OBJECTIVE
  To investigate the reconstruction of digital three-dimensional (3D) model of normal human placental vascular network based on MRI data in vitro.
  
  
  METHODS
  Six full term placentas were collected, casted with modified self-curing denture base resin and scanned by T1 e-THRIVE high resolution magnetic resonance imaging. MRI images were imported into Mimics 14.0 software for 3D reconstruction, and the 3D model was compared with placental vascular casting model.
  
  
  RESULTS
  (1) The placental vascular network could be obtained on MR 2D images. The 3D model were reconstructed successfully, which showed clear, realistic images. The 3D model could be zoomed and revolved from any direction to observe the branches of arteries and veins. (2) The umbilical vein and 2 umbilical arteries could be seen in the 3D model. In the root of the umbilical cord, the umbilical vein divided into 5-7 branches. While the 2 umbilical arteries anatomoses to form blood sinus and then devided into sub-branches. All the peripheral vessels ended in chorionic plate with abundant sub-branches. (3) When compared with the casting of placental arterial-venous vascular network, the morphology, structure, angle and trend of vessels in 3D model was consistent with the casting network.
  
  
  CONCLUSIONS
  Reconstruction of digital 3D model of normal human placental vascular network based on MRI in vitro is a new and promising method for the study of placental vasculature. It has better vascular exposure, free rotation, radiation-free. It provides a promising base for the study of placental vasculature in vivo in the future.
authors.affiliation: Department of Obstetrics and Gynecology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China. Email: wangzhijian2046@sina.com.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wang
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Zhu
authors.forename: Jin
authors.initials: J
authors.lastname: Shi
authors.forename: Caixia
authors.initials: C
authors.lastname: Li
authors.forename: Zhaoqiang
authors.initials: Z
authors.lastname: Yun
authors.forename: Yanhong
authors.initials: Y
authors.lastname: He
authors.forename: Yuying
authors.initials: Y
authors.lastname: Chen
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Cao
mesh_terms: D002823:Chorion; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008833:Microcirculation / Q000502:physiology; D008953:Models, Anatomic; D010920:Placenta / Q000033:anatomy & histology / Q000098:blood supply*; D011247:Pregnancy; D014469:Umbilical Arteries / Q000033:anatomy & histology* / Q000502:physiology; D014470:Umbilical Cord / Q000033:anatomy & histology / Q000098:blood supply*