title: Value of 3 Tesla diffusion-weighted magnetic resonance imaging for assessing liver fibrosis.
abstract: BACKGROUND
  Limited data are available regarding the role of magnetic resonance imaging (MRI), particularly the new generation 3 Tesla technology, and especially diffusion-weighted imaging (DWI) in predicting liver fibrosis. The aim of our pilot study was to assess the clinical performance of the apparent diffusion coefficient (ADC) of liver parenchyma for the assessment of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  18 patients with biopsy-proven NAFLD underwent DWI with 3 Tesla MRI. DWI was performed with single-shot echo-planar technique at b values of 0-500 and 0-1000 s/mm2. ADC was measured in four locations in the liver and the mean ADC value was used for analysis. Staging of fibrosis was performed according to the METAVIR system.
  
  
  RESULTS
  The median age of patients was 52 years (range 23-73). The distribution of patients in different fibrosis stages was: 0 (n=1), 1 (n=7), 2 (n=1), 3 (n=5), 4 (n=4). Fibrosis stage was poorly associated with ADC at b value of 0-500 s/mm2(r= -0.30, P=0.27). However it was significantly associated with ADC at b value of 0-1000 s/mm2(r= -0.57, P=0.01). For this b value (0-1000 s/mm2) the area under receiver-operating characteristic curve was 0.93 for fibrosis stage ≥3 and the optimal ADC cut-off value was 1.16 ×10-3mm2/s.
  
  
  CONCLUSIONS
  3 Tesla DWI can possibly predict the presence of advanced fibrosis in patients with NAFLD.
authors.affiliation: 4 Internal Medicine Unit, University of Thessaloniki (Lavrentios Papalavrentios, Emmanouil Sinakos, Evangelos Akriviadis), Greece.
authors.forename: Lavrentios
authors.initials: L
authors.lastname: Papalavrentios
authors.affiliation: 4 Internal Medicine Unit, University of Thessaloniki (Lavrentios Papalavrentios, Emmanouil Sinakos, Evangelos Akriviadis), Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Sinakos
authors.affiliation: Department of Radiology, Interbalkan Medical Center, Thessaloniki (Danai Chourmouzi, Konstantinos Drevelegas, Manos Constantinides, Antonios Drevelegas), Greece.
authors.forename: Danai
authors.initials: D
authors.lastname: Chourmouzi
authors.affiliation: Department of Pathology, University of Thessaloniki (Prodromos Hytiroglou), Greece.
authors.forename: Prodromos
authors.initials: P
authors.lastname: Hytiroglou
authors.affiliation: Department of Radiology, Interbalkan Medical Center, Thessaloniki (Danai Chourmouzi, Konstantinos Drevelegas, Manos Constantinides, Antonios Drevelegas), Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Drevelegas
authors.affiliation: Department of Radiology, Interbalkan Medical Center, Thessaloniki (Danai Chourmouzi, Konstantinos Drevelegas, Manos Constantinides, Antonios Drevelegas), Greece.
authors.forename: Manos
authors.initials: M
authors.lastname: Constantinides
authors.affiliation: Department of Radiology, Interbalkan Medical Center, Thessaloniki (Danai Chourmouzi, Konstantinos Drevelegas, Manos Constantinides, Antonios Drevelegas), Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Drevelegas
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN, USA (Jayant Talwalkar).
authors.forename: Jayant
authors.initials: J
authors.lastname: Talwalkar
authors.affiliation: 4 Internal Medicine Unit, University of Thessaloniki (Lavrentios Papalavrentios, Emmanouil Sinakos, Evangelos Akriviadis), Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Akriviadis
keywords: 3 Tesla; Keywords Liver fibrosis; diffusion-weighted imaging; non-alcoholic fatty liver