title: Ovarian preservation in young women with endometrial cancer of endometrioid histology.
abstract: OBJECTIVE
  To clarify the frequency and risk factors of ovarian metastasis in women with endometrial cancer of endometrioid histology.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  University of the Ryukyus Japan 1990-2011.
  
  
  METHODS
  Eighty-eight women ≤ 45 years of age with endometrial cancer of only endometrioid histology.
  
  
  METHODS
  Clinicopathological factors from the medical records were used. Fisher's exact test and logistic regression analysis were used to analyze predictive factors for ovarian metastasis.
  
  
  METHODS
  Risk factors of ovarian malignancy.
  
  
  RESULTS
  All women underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and lymph node dissection. The median age was 39 years, and FIGO stage distributions were: stage I, 63 (71.6%) women; stage II, 14 (15.9%) women; and stage III, 11 (12.5%) women. Pathologically, ovarian metastasis was observed in four (4.5%) women. Only lymph node metastasis was a significant predictive factor for ovarian metastasis (p = 0.0038), and deep myometrial invasion was the only significant factor (p = 0.0085) for the prediction of lymph node metastasis. No ovarian malignancy was found in 72 women with invasion ≤ 50% myometrial depth and no enlargement of the ovaries. We observed ovarian metastasis in two (14.3%) of 14 women with deep myometrial invasion without ovarian tumor.
  
  
  CONCLUSIONS
  Ovarian preservation surgery might be considered in endometrial cancer of endometrioid histology with ≤ 50% myometrial depth invasion with no ovarian mass after taking into account family history.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
authors.forename: Yoshino
authors.initials: Y
authors.lastname: Kinjyo
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.forename: Takuma
authors.initials: T
authors.lastname: Ooyama
authors.forename: Morihiko
authors.initials: M
authors.lastname: Inamine
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D018269:Carcinoma, Endometrioid / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D016015:Logistic Models; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000556:secondary*; D010052:Ovariectomy; D010388:Pelvis; D012189:Retrospective Studies; D012307:Risk Factors; D058994:Salpingectomy
keywords: Endometrial cancer; endometrioid adenocarcinoma; hysterectomy; ovarian presentation; young patients