title: Coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency.
abstract: In this report, we review 2 cases of coronary revascularization in patients with a diagnosis of coronary artery disease and preoperative protein S deficiency, an established hypercoagulable condition. In an attempt to normalize protein S levels, fresh frozen plasma was used as the priming fluid for the cardiopulmonary bypass circuit before the initiation of extracorporeal circulation. On the basis of a low risk of bleeding and the theoretical risk of thrombosis, neither patient received intraoperative antifibrinolytic treatment nor did they develop perioperative thrombotic complications.
authors.affiliation: From the Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
authors.forename: Yen-Michael S
authors.initials: YM
authors.lastname: Hsu
authors.forename: George J
authors.initials: GJ
authors.lastname: Despotis