title: In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets.
abstract: BACKGROUND
  Polyelectrolyte complexes (PECs) are the association complexes formed between oppositely charged particles (e.g., polymer-polymer, polymer-drug and polymer-drug-polymer). These are formed due to electrostatic interaction between oppositely charged polyions. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) advocated in use of painful and inflammatory rheumatic and certain non-rheumatic conditions. The drug has a relatively short elimination half-life, which limits the potential for drug accumulation. As an analgesic, it has a fast onset and long duration of action.
  
  
  OBJECTIVE
  invitro-invivo evaluation of Xanthan gum and Eudragit E100 inter polyelectrolyte complex based sustained release tablet.
  
  
  METHODS
  Xanthan gum and Eudragit E100 were used as PEC and were prepared using different proportions i.e. in 1:1 to 1:6 ratio. The optimum ratio of E100 and XG was 1:6 used to characterize the IPC and the formulation of tablet. The tablets were prepared by wet granulation using PVP K30 as binder.
  
  
  CONCLUSIONS
  FT-IR and DSC studies confirmed the formation of IPC. Scanning Electron Microscopy (SEM) studies showed highly porous tablet surface. The tablets were evaluated for hardness, weight variation, and drug content, found to be within limits. In vitro and in vivo studies concluded that tablets showed sustained release profile. The short term stability study of the optimized formulation indicated that the formulation was stable.
  
  
  CONCLUSIONS
  Since the Poly Electrolyte Complex delay the release of the drug, it can be employed in formulating sustained release matrix tablets.
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
authors.forename: Tamal Krishna
authors.initials: TK
authors.lastname: Deb
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Ramireddy
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
authors.forename: Afrasim
authors.initials: A
authors.lastname: Moin
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
authors.forename: H G
authors.initials: HG
authors.lastname: Shivakumar
keywords: Diclofenac sodium; eudragit; inter polyelectrolyte complex; sustained release; xanthan gum