title: [Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities].
abstract: Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Wang
authors.forename: Yi-xun
authors.initials: YX
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Wen
authors.forename: He-shui
authors.initials: HS
authors.lastname: Yu
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Kang
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.lastname: Zhao Yang
authors.forename: Bai-ping
authors.initials: BP
authors.lastname: Ma
authors.forename: Yun-dai
authors.initials: YD
authors.lastname: Chen
mesh_terms: D000818:Animals; D027742:Dioscorea / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins