title: Biological properties of a new volumizing hyaluronic acid filler: a systematic review.
abstract: BACKGROUND
  Hyaluronic acid (HA) dermal fillers are effective and safe for correction of facial rhytides. A new volumizing HA filler, 20 mg/ml HA dermal filler (Juvéderm® Voluma®, Allergan Inc., Irvine, CA), is the only HA filler with a FDA indication for facial volumization due to age-related facial volume loss.
  
  
  OBJECTIVE
  Evaluate the biological properties, including biochemical, biophysical and rheological, of this new 20 mg/ml HA dermal filler and discuss the importance of these properties in clinical applications.
  
  
  METHODS
  A systematic search of the computerized bibliographic databases Medline, Embase, Embal, Biosis, SciSearch, Pascal, HCAPlus, IPA, and Dissertation Abstracts with key term "Voluma." Four articles on the biological properties of this new 20 mg/ ml HA dermal filler were suitable for inclusion in this review.
  
  
  RESULTS
  Biological analysis of elasticity and viscosity values of this new 20 mg/ml HA dermal filler demonstrated intermediate properties in three studies and high in one study compared to other HA dermal fillers. This 20 mg/ml HA dermal filler retained the highest elasticity and viscosity values at temperature of 37°C. Histology demonstrated that this 20 mg/ml HA dermal filler has an intermediate pattern of distribution within the superficial and deep reticular dermis.
  
  
  CONCLUSIONS
  This 20 mg/ml HA dermal filler demonstrated volumizing ability, and maintaining viscosity and free-flowing characteristics for easy injection, tissue lifting, and molding. We hope future research incorporates biological properties analysis of this HA dermal filler in clinical trials.
authors.forename: Derek
authors.initials: D
authors.lastname: Ho
authors.forename: Jared
authors.initials: J
authors.lastname: Jagdeo
mesh_terms: D003357:Cosmetic Techniques; D004548:Elasticity; D005145:Face; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000737:chemistry; D007267:Injections; D012212:Rheology; D015595:Skin Aging / Q000187:drug effects*; D014783:Viscosity
chemical_list: D006820:Hyaluronic Acid