title: Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.
abstract: Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.
authors.forename: Tim
authors.initials: T
authors.lastname: Lekic
authors.forename: Damon
authors.initials: D
authors.lastname: Klebe
authors.forename: Roy
authors.initials: R
authors.lastname: Poblete
authors.forename: Paul R
authors.initials: PR
authors.lastname: Krafft
authors.forename: William B
authors.initials: WB
authors.lastname: Rolland
authors.forename: Jiping
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall Rm 219, Loma Linda, California, 92354, USA. johnzhang3910@yahoo.com.
authors.forename: John H
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D002543:Cerebral Hemorrhage / Q000151:congenital* / Q000473:pathology / Q000503:physiopathology*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism; D009415:Nerve Net / Q000098:blood supply* / Q000503:physiopathology*