title: Eravacycline (TP-434) is active in vitro against biofilms formed by uropathogenic Escherichia coli.
abstract: Eravacycline (formerly TP-434) was evaluated in vitro against pre-established biofilms formed by a uropathogenic Escherichia coli strain. Biofilms were eradicated by 0.5 μg/ml eravacycline, which was within 2-fold of the MIC for planktonic cells. In contrast, colistin and meropenem disrupted biofilms at 32 and 2 μg/ml, respectively, concentrations well above their respective MICs of 0.5 and 0.03 μg/ml. Gentamicin and levofloxacin eradicated biofilms at concentrations within 2-fold of their MICs.
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA tgrossman@tphase.com.
authors.forename: Trudy H
authors.initials: TH
authors.lastname: Grossman
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA.
authors.forename: William
authors.initials: W
authors.lastname: O'Brien
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA.
authors.forename: Kathryn O
authors.initials: KO
authors.lastname: Kerstein
authors.affiliation: Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA.
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Sutcliffe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D003091:Colistin / Q000494:pharmacology; D015169:Colony Count, Microbial; D004927:Escherichia coli Infections / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D064704:Levofloxacin / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013754:Tetracyclines / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology; D056689:Uropathogenic Escherichia coli / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D013754:Tetracyclines; D013845:Thienamycins; C571179:eravacycline; D064704:Levofloxacin; D000077731:Meropenem; D003091:Colistin