title: The TITAN-AMI multicenter registry evaluating the usage of Titan2 stent in patients with ST segment elevation myocardial infarction. Final result at 12-month follow-up.
abstract: OBJECTIVE
  Primary percutaneous coronary intervention with stent implantation is the recommended treatment for patients with ST elevation myocardial infarction (STEMI). Data from randomised trials showed good performance by a titanium-nitric-oxide coated stent in this context. The aim of this study was to confirm these data.
  
  
  METHODS
  A multicentre registry was compiled in 23 hospitals in Spain in an all-comers population. We selected patients with STEMI from a global Titan AMI registry that included patients with acute coronary syndrome. Primary endpoint was the composite of cardiac death, non-fatal myocardial infarction, stent thrombosis and target lesion revascularisation, at 12-month follow-up.
  
  
  RESULTS
  The study included 893 patients with STEMI. We included all possibilities for PCI: 86.6% primary, 5% facilitated after successful fibrinolysis and 8.4% rescue PCI after failed fibrinolysis. The primary endpoint was reached in 8.4% of the patients: cardiac death 2.7%, reinfarction 3.4%, target lesion revascularisation 3.5% and definite or probable stent thrombosis 2.8%. The majority of stent thromboses presented in the first 30 days after PCI.
  
  
  CONCLUSIONS
  A bioactive stent (titanium-nitric-oxide coated stent) is a possible alternative for the treatment of patients with STEMI. One-year follow-up showed better results than those presented by a regular bare-metal stent or first-generation drug-eluting stent in terms of stent thrombosis.
authors.forename: J A
authors.initials: JA
authors.lastname: Gómez-Hospital
authors.forename: J
authors.initials: J
authors.lastname: Mauri
authors.forename: E
authors.initials: E
authors.lastname: Pinar
authors.forename: J
authors.initials: J
authors.lastname: Goicolea
authors.forename: B
authors.initials: B
authors.lastname: García Del Blanco
authors.forename: A
authors.initials: A
authors.lastname: Serra
authors.forename: H
authors.initials: H
authors.lastname: Tizon-Marcos
authors.forename: E
authors.initials: E
authors.lastname: Molina
authors.forename: E
authors.initials: E
authors.lastname: Sanchez
authors.forename: V
authors.initials: V
authors.lastname: Aragón
authors.forename: M
authors.initials: M
authors.lastname: Masotti
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: R
authors.initials: R
authors.lastname: Ortas
authors.forename: P
authors.initials: P
authors.lastname: Martínez
authors.forename: B
authors.initials: B
authors.lastname: Serra
authors.forename: J
authors.initials: J
authors.lastname: Moreu
authors.forename: G
authors.initials: G
authors.lastname: Diego Nieto
authors.forename: F
authors.initials: F
authors.lastname: Bossa
authors.forename: J M
authors.initials: JM
authors.lastname: Nogales
authors.forename: J
authors.initials: J
authors.lastname: Bassaganyas
authors.forename: J
authors.initials: J
authors.lastname: Díaz
authors.forename: J D
authors.initials: JD
authors.lastname: Cascón
mesh_terms: D054058:Acute Coronary Syndrome / Q000601:surgery*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D012042:Registries; D013030:Spain; D015607:Stents; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: C434243:titanium-nitride-oxide; D014025:Titanium