title: Tough and biocompatible hydrogels based on in situ interpenetrating networks of dithiol-connected graphene oxide and poly(vinyl alcohol).
abstract: An interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the efforts have been focused on organic/organic networks. Herein, aqueous dispersible 2,2'-(ethylenedioxy)-diethanethiol (EDDET) cross-linked graphene oxide (E-cGO) skeleton was in situ incorporated into a PVA matrix, resulting in novel inorganic/organic IPN hydrogels with super mechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated as being biocompatible, which make the E-cGO/PVA hydrogels promising candidate biomaterials for load-bearing biotissue substitution.
authors.affiliation: Polymers and Composites Division, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences , Zhongguan West Road 1219, Zhenhai District, Ningbo, Zhejiang 315201, P.R. China.
authors.forename: Gaolai
authors.initials: G
authors.lastname: Du
authors.forename: Lei
authors.initials: L
authors.lastname: Nie
authors.forename: Guorong
authors.initials: G
authors.lastname: Gao
authors.forename: Yuanna
authors.initials: Y
authors.lastname: Sun
authors.forename: Ruixia
authors.initials: R
authors.lastname: Hou
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Fu
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D019245:Compressive Strength; D055119:Elastic Modulus; D006108:Graphite / Q000737:chemistry*; D006244:Hardness; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis*; D006860:Hydrogen Bonding; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D010087:Oxides; D013438:Sulfhydryl Compounds; D006108:Graphite; D011142:Polyvinyl Alcohol
keywords: IPN; cell-adhesion; hydrogel; inorganic/organic; tough