title: Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis.
abstract: Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n=43) and healthy controls (n=44). Positive and negative symptoms were assessed twice over 12months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Electronic address: derek.dean@colorado.edu.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Dean
authors.affiliation: Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Minneapolis VA Health Care System, Minneapolis, MN, USA.
authors.forename: Jerillyn S
authors.initials: JS
authors.lastname: Kent
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Bernard
authors.affiliation: Institute for Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Orr
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Gupta
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pelletier-Baldelli
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Carol
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Vijay A
authors.initials: VA
authors.lastname: Mittal
mesh_terms: D000293:Adolescent; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007406:Interview, Psychological; D016014:Linear Models; D008297:Male; D004856:Postural Balance; D011187:Posture; D062706:Prodromal Symptoms; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D012306:Risk; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Cerebellum; Cognitive dysmetria; Postural sway; Psychosis; Ultrahigh risk