title: [Protective effect of epigallocatechin gallate against sperm abnormality in mice].
abstract: OBJECTIVE
  To investigate the protective effect of epigallocatechin gallate (EGCG) on mouse sperm in vivo.
  
  
  METHODS
  A total of 64 six-week-old male Kuming mice were randomly divided into eight groups of equal number to be treated with normal saline (negative control), Cyclophosphamide (CP) at 30 mg/kg (positive control), and CP followed by EGCG (experimental) at 20, 40, and 80 mg/kg, respectively, given every other day for 10 days. At 4 and 5 weeks after treatment, the bilateral testes of the mice were harvested for examination of sperm abnormality.
  
  
  RESULTS
  EGCG did not increase the rate of CP-induced sperm abnormality in the mice, but reduced it instead with the prolonged time of treatment.
  
  
  CONCLUSIONS
  EGCG protects mouse sperm in vivo.
authors.affiliation: Nanjing General Hospital of Nanjing Military Region, Jiangsu, China. suiliucai@gmail.com
authors.forename: Liu-Cai
authors.initials: LC
authors.lastname: Sui
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Ge
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Xu
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Wu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Fu
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003520:Cyclophosphamide / Q000633:toxicity; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D011897:Random Allocation; D013094:Spermatozoa / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009153:Mutagens; D003520:Cyclophosphamide; D002392:Catechin; C045651:epigallocatechin gallate