title: Objectively Measured Sleep and β-amyloid Burden in Older Adults: A Pilot Study.
abstract: OBJECTIVE
  Although disturbed sleep is associated with cognitive deficits, the association between sleep disturbance and Alzheimer's disease (AD) pathology is unclear. In this pilot study, we examined the extent to which sleep duration, sleep quality, and sleep-disordered breathing (SDB) are associated with β-amyloid (Aβ) deposition in the brains of living humans.
  
  
  METHODS
  We studied 13 older adults (8 with normal cognition and 5 with mild cognitive impairment (MCI)). Participants completed neuropsychological testing, polysomnography and Aβ imaging with [11C]-Pittsburgh compound B.
  
  
  RESULTS
  Among participants with MCI, higher apnea-hypopnea index and oxygen desaturation index were associated with greater Aβ deposition, globally and regionally in the precuneus. There were no significant associations between SDB and Aβ deposition among cognitively normal participants. There were no significant associations between sleep duration or sleep fragmentation and Aβ deposition.
  
  
  CONCLUSIONS
  These preliminary results suggest that, among older adults with MCI, greater SDB severity is associated with greater Aβ deposition.
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD ; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Spira
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors.forename: Christopher
authors.initials: C
authors.lastname: Yager
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD ; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD ; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD ; The Copper Ridge Institute, Sykesville, MD.
authors.forename: Jason
authors.initials: J
authors.lastname: Brandt
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Anil
authors.initials: A
authors.lastname: Mathur
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: James R
authors.initials: JR
authors.lastname: Brašić
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD ; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD ; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD ; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
authors.forename: Dean F
authors.initials: DF
authors.lastname: Wong
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD ; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Wu
keywords: Alzheimer’s disease; amyloid; mild cognitive impairment; positron emission tomography; sleep; sleep apnea