title: Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness: A Study Among 1777 Cognitively Normal Subjects.
abstract: BACKGROUND
  Increasing evidence has emerged that there is a link between body weight and the risk of developing dementia. However, the relationship between adiposity and brain structure has not yet been fully elucidated. We aimed to evaluate the association of body fat composition with cortical thickness in cognitively normal subjects.
  
  
  METHODS
  In total, 1777 (887 men and 890 women) cognitively normal subjects, aged 45 years or older, were recruited from the Health Promotion Center in South Korea. Medical records including 3-dimensional magnetic resonance imaging, body fat percentage, waist-hip ratio (WHR), and other factors were reviewed.
  
  
  RESULTS
  In men, the percentage of fat was positively associated with cortical thickness and the highest WHR group showed significantly decreased cortical thickness compared with the reference group. WHR showed an inverted U-shaped association with total cortical thickness and frontal lobe thickness in men. Among women, there was no significant association.
  
  
  CONCLUSIONS
  Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness.
authors.affiliation: *Department of Neurology, Neuroscience center ∥Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine Departments of ‡Preventive Medicine ¶Neurology, Gangnam Severance Hospital #Neurology, Yonsei University College of Medicine §Department of Biomedical Engineering, Hanyang University, Seoul, Korea †Department of Medicine, Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Changsoo
authors.initials: C
authors.lastname: Kim
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.forename: Mira
authors.initials: M
authors.lastname: Kang
authors.forename: Yeo Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Hee-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Hanna
authors.initials: H
authors.lastname: Cho
authors.forename: Byoung Seok
authors.initials: BS
authors.lastname: Ye
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Jang
authors.forename: Jaelim
authors.initials: J
authors.lastname: Cho
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Rexrode
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism / Q000473:pathology; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology*; D002540:Cerebral Cortex / Q000473:pathology*; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D049629:Waist-Hip Ratio / Q000639:trends*