title: Hair mercury concentrations and in vitro fertilization (IVF) outcomes among women from a fertility clinic.
abstract: Total hair mercury (Hg) was measured among 205 women undergoing in vitro fertilization (IVF) treatment and the association with prospectively collected IVF outcomes (229 IVF cycles) was evaluated. Hair Hg levels (median=0.62ppm, range: 0.03-5.66ppm) correlated with fish intake (r=0.59), and exceeded the recommended EPA reference of 1ppm in 33% of women. Generalized linear mixed models with random intercepts accounting for within-woman correlations across treatment cycles were used to evaluate the association of hair Hg with IVF outcomes adjusted for age, body mass index, race, smoking status, infertility diagnosis, and protocol type. Hair Hg levels were not related to ovarian stimulation outcomes (peak estradiol levels, total and mature oocyte yields) or to fertilization rate, embryo quality, clinical pregnancy rate or live birth rate.
authors.affiliation: Vincent Department of Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital Fertility Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Diane L
authors.initials: DL
authors.lastname: Wright
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Myriam C
authors.initials: MC
authors.lastname: Afeiche
authors.affiliation: Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Shelley
authors.initials: S
authors.lastname: Ehrlich
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Smith
authors.affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Chavarro
authors.affiliation: Vincent Department of Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital Fertility Center, Harvard Medical School, Boston, MA, USA.|Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics & Pediatric Endocrinology Inter-Institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Batsis
authors.affiliation: Vincent Department of Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital Fertility Center, Harvard Medical School, Boston, MA, USA.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Toth
authors.affiliation: Vincent Department of Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVF, Massachusetts General Hospital Fertility Center, Harvard Medical School, Boston, MA, USA.|Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
mesh_terms: D000328:Adult; D000818:Animals; D033364:Decapoda; D004032:Diet; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D005307:Fertilization in Vitro; D005399:Fishes; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008628:Mercury / Q000032:analysis*; D010062:Ovulation Induction; D049897:Pectinidae; D011247:Pregnancy; D011256:Pregnancy Outcome; D017747:Seafood
chemical_list: D004785:Environmental Pollutants; D008628:Mercury
keywords: Fertilization; Human; Implantation; In vitro fertilization (IVF); Mercury (Hg); Oocyte