title: Occupational exposures and risk of stomach and esophageal cancers: update of a cohort of female textile workers in Shanghai, China.
abstract: BACKGROUND
  Associations between stomach and esophageal cancer and exposures to dusts, metals, chemicals, and endotoxin in the workplace are not very well understood, particularly in women.
  
  
  METHODS
  We followed 267,400 female textile workers in Shanghai, China for cancer incidence from 1989 to 2006. Stomach (n = 1374) and esophageal (n = 190) cancer cases were identified and a comparison subcohort (n = 3187) was randomly selected. Cox proportional hazard modeling was used, adjusting for age and smoking.
  
  
  RESULTS
  Increasing stomach cancer risk was observed with increasing duration of synthetic fiber dust exposure (p = 0.03), although the magnitude of effect was small (20 + years: HR = 1.2, 95% CI 1.1-1.4). Trends with endotoxin exposure were modestly inversed for esophageal cancer and increased for stomach cancer, but with little deviation from a null association.
  
  
  CONCLUSIONS
  Our findings demonstrate that long durations of synthetic fiber dust exposure can increase stomach cancer risk in women, but provide limited support for associations with other textile industry exposures.
authors.affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Gallagher
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.forename: Roberta M
authors.initials: RM
authors.lastname: Ray
authors.forename: Megan E
authors.initials: ME
authors.lastname: Romano
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Wernli
authors.forename: Dao L
authors.initials: DL
authors.lastname: Gao
authors.forename: David B
authors.initials: DB
authors.lastname: Thomas
authors.forename: Harvey
authors.initials: H
authors.lastname: Checkoway
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004391:Dust; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology*; D013783:Textile Industry
chemical_list: D004391:Dust
keywords: China; cancer; cohort; endotoxin; textiles