title: In vitro assessment of dual drug combinations to inhibit growth of Neisseria gonorrhoeae.
abstract: The development of resistance to first-line antimicrobial therapies has led to recommendations for combination therapies for the treatment of gonorrhea infection. Recent studies have shown the success of combination therapies in treating patients, but few have reported on the in vitro activities of these drug combinations. An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Pettus
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Samera
authors.initials: S
authors.lastname: Sharpe
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA jwp6@cdc.gov.
authors.forename: John R
authors.initials: JR
authors.lastname: Papp
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D004338:Drug Combinations; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D005839:Gentamicins / Q000494:pharmacology; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D017963:Azithromycin