title: SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation.
abstract: SYF2 is reported to be as a cell cycle regulator at the G1/S transition and encodes a nuclear protein that interacts with cyclin-D-type binding protein 1. In our study, we investigated the role of SYF2 in human epithelial ovarian cancer (EOC) progression. Western blot and immunohistochemistry analysis displayed that SYF2 was overexpressed in EOC tissues and EOC cell lines. In addition, the immunoreactivity of SYF2 was positively correlated with tumor grade and Ki-67 expression. In vitro, serum starvation-refeeding experiment and SYF2-siRNA transfection assay demonstrated that the expression of SYF2 was promoted in the proliferative progression of EOC cells, while knockdown of SYF2 expression decreased and inhibited cell growth rate of EOC cells. With all the results, we support that SYF2 might contribute to EOC progression via modulation of proliferation in EOC cells and would provide a novel therapeutic target of human EOC.
authors.affiliation: Department of Pathogen Biology, Medical College, Jiangsu Provice Key Laboratory for Information and Molecular Drug Target, Nantong University, Nantong, 226001, Jiangsu Province, People's Republic of China.
authors.forename: Sujuan
authors.initials: S
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiang
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Xi
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Shuyun
authors.initials: S
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Chunhui
authors.initials: C
authors.lastname: Tang
authors.forename: Jianxin
authors.initials: J
authors.lastname: Zhong
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D063646:Carcinogenesis; D000077216:Carcinoma, Ovarian Epithelial; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016601:RNA-Binding Proteins
chemical_list: C418608:GCIP-interacting protein p29, human; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins