title: Multimodal imaging in paclitaxel-induced macular edema: the microtubule disfunction.
abstract: Taxanes are a rare cause of macular edema. A 63-year-old female, under paclitaxel treatment, was observed with progressively bilateral visual acuity loss and an apparently normal fundus. Optical coherence tomography revealed a bilateral cystoid macular edema with a late petaloid pooling on fluorescein angiography. Fundus autofluorescence exhibited a foveal hiperautofluorescent pattern. There was a great improvement of visual acuity and macular thickness after 5 months of drug withdrawal. Paclitaxel maculopathy diagnosis requires a high degree of suspicion. The pathophysiology remains unclear.
authors.affiliation: a Department of Anatomy, Faculty of Medicine , University of Porto , Porto , Portugal .|b Department of Ophthalmology , Centro Hospitalar Sao Joao , Porto , Portugal , and.
authors.forename: Paulo
authors.initials: P
authors.lastname: Freitas-da-Costa
authors.affiliation: b Department of Ophthalmology , Centro Hospitalar Sao Joao , Porto , Portugal , and.
authors.forename: Elisete
authors.initials: E
authors.lastname: Brandão
authors.affiliation: b Department of Ophthalmology , Centro Hospitalar Sao Joao , Porto , Portugal , and.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bragança
authors.affiliation: b Department of Ophthalmology , Centro Hospitalar Sao Joao , Porto , Portugal , and.|c Department of Sense Organs, Faculty of Medicine , University of Porto , Porto , Portugal.
authors.forename: Fernando
authors.initials: F
authors.lastname: Falcão-Reis
authors.affiliation: b Department of Ophthalmology , Centro Hospitalar Sao Joao , Porto , Portugal , and.|c Department of Sense Organs, Faculty of Medicine , University of Porto , Porto , Portugal.
authors.forename: Angela
authors.initials: A
authors.lastname: Carneiro
mesh_terms: D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008269:Macular Edema / Q000139:chemically induced* / Q000175:diagnosis; D008870:Microtubules / Q000187:drug effects*; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D050257:Tubulin Modulators / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity / Q000187:drug effects*
chemical_list: D050257:Tubulin Modulators; D017239:Paclitaxel
keywords: Angiography; cystoid macular edema; fundus autofluorescence; optical coherence tomography; paclitaxel; taxanes