title: The healing effect of scrophularia striata on experimental burn wounds infected to pseudomonas aeruginosa in rat.
abstract: BACKGROUND
  The cause of death in burn patients after 48 hours of hospitalization has been reported to be bacterial infections. Recently, due to the compounds accelerating the healing process and the intense reduction of treatment side effects, medicinal plants are used to cure burn wound infections. This study aims to investigate the medicinal effect of the ethanolic extract of Scrophularia striata on burn wound infection in in-vivo and in-vitro in comparison with silver sulfadiazine (SSD).
  
  
  METHODS
  One hundred and fifty male Sprague Dawley rats were divided into 3 equal groups. A hot plate of 1×1cm was used to create second degree burn wounds. The ethanolic extract of S. striata was provided through percolation method. Group 1 was treated with SSD, group 2 with S. striata, and group 3 was considered as control group. All animals were infected to Pseudomonas aeruginosa. On days 3, 7, 10, 14, and 21 after burn wound injury, the animals were euthanized and were evaluated histologically. The MIC and MBC were determined using the micro dilution method.
  
  
  RESULTS
  The rate of wound healing was significantly greater in S. striata group in comparison to SSD and control groups.
  
  
  CONCLUSIONS
  S. striata contains was shown to have anti-bacterial and wound healing effects while this effect was significantly more than SSD denoting to its use when needed for burn wounds infected to P. aeruginosa.
authors.affiliation: Shiraz Burn Research Center, Pharmacology Department, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
authors.affiliation: Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Haddadi
authors.affiliation: Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Rokni-Hosseini
authors.affiliation: Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Masood
authors.initials: M
authors.lastname: Hossienzadeh
authors.affiliation: Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
authors.affiliation: Prevention of Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran;
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sayehmiri
authors.affiliation: Laboratory Animal Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Koohi-Hossienabadi
keywords: Healing; Pseudomonas aeruginosa; Scrophularia striata; Silver sulfadiazine; Wound