title: Microsomal transfer protein inhibitors, new approach for treatment of familial hypercholesterolemia, review of the literature, original findings, and clinical significance.
abstract: The genetic causes of cholesterol metabolism disorders usually lead to premature atherosclerosis. The most well recognized genetically caused hypercholesterolemia is familial hypercholesterolemia. Although the disease is well known, as the discovery of low-density lipoprotein receptor, the classical treatment with lipid-lowering drugs (statins, fibrates, ezetimibe, colesevelam) is still not adequate and new options are seeking. This review is an attempt to analyze the microsomal transfer protein (MTP) inhibitors as a new approach for treatment of familial hypercholesterolemia, to reviews the literature according to MTP inhibitors and finally to provide original findings.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Genovefa
authors.initials: G
authors.lastname: Kolovou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vasiliadis
authors.forename: Nikos
authors.initials: N
authors.lastname: Gontoras
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.forename: Georgios
authors.initials: G
authors.lastname: Hatzigeorgiou
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D015195:Drug Design; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D058990:Molecular Targeted Therapy; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D015415:Biomarkers; D002352:Carrier Proteins; C106092:microsomal triglyceride transfer protein; D002784:Cholesterol
keywords: Familial hypercholesterolemia; LDL apheresis; Lomitapide