title: Secondary acute myeloid leukemia arising early after cyclophosphamide treatment.
abstract: BACKGROUND
  Acute myeloid leukemia (AML) can develop secondary to drug treatment. This phenomenon has been placed under the title "Therapy Related Acute Myeloid Leukemias and Myelodysplastic Syndromes" in the WHO classification of AML. Cyclophosphamide, which is used in various malignancies and rheumatological diseases, is an alkylating agent that plays a significant role in therapy related AML.
  
  
  METHODS
  A patient treated with cyclophosphamide due to vasculitis, subsequently developed AML months after treatment.
  
  
  CONCLUSIONS
  Cyclophosphamide related AML is seen, in most cases, many years after exposure to the drug. The significance of this report lies in the fact that, to our knowledge, this is the most rapidly arising case of cyclophosphamide related AML.
authors.affiliation: Ic Hastaliklari ABD, Gazi Universitesi Hastanesi, 06500, Besevler, Ankara, Turkey, hayretdink@gmail.com.
authors.forename: Hayretdin
authors.initials: H
authors.lastname: Koklu
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tufan
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Erkul
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyurek
authors.forename: Ramazan
authors.initials: R
authors.lastname: Civelek
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide