title: New ansamycin derivatives generated by simultaneous mutasynthesis.
abstract: The conversion from triene- to diene-typed ansamycins is clarified step by step in Streptomyces seoulensis IFB-A01. Such an intertype convertibility is adopted to establish for the first time the simultaneous mutasynthesis of both types of C17-benzene ansamycins (C17BAs). Three of the newly generated unnatural compounds showed potent cytotoxicity.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing, 210093, China.
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Song
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Jiao
authors.forename: Wen Jing
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Guo Yan
authors.initials: GY
authors.lastname: Zhao
authors.forename: Huan
authors.initials: H
authors.lastname: Dou
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.forename: Ai Hua
authors.initials: AH
authors.lastname: Zhang
authors.forename: Ya Yi
authors.initials: YY
authors.lastname: Hou
authors.forename: Shu Feng
authors.initials: SF
authors.lastname: Bi
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D047029:Lactams, Macrocyclic / Q000737:chemistry; D061986:MCF-7 Cells; D015394:Molecular Structure; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047029:Lactams, Macrocyclic; D017828:Rifabutin