title: Antibacterial drug discovery: doing it right.
abstract: Antibacterial drug discovery needs to develop new strategies to identify attractive hit-target couples for more effective lead finding and optimization. In this issue of Chemistry & Biology, Park and coworkers describe a novel target-based whole cell combination screening approach resulting in the identification of new inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.
authors.affiliation: Tuberculosis Research Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117545, Republic of Singapore.
authors.forename: Martin
authors.initials: M
authors.lastname: Gengenbacher
authors.affiliation: Antibacterial Drug Discovery Laboratory, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117545, Republic of Singapore. Electronic address: thomas_dick@nuhs.edu.sg.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dick
mesh_terms: D001710:Biotin / Q000096:biosynthesis*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*
chemical_list: D001710:Biotin