title: PNA-encoded chemical libraries.
abstract: Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided a powerful new paradigm for library synthesis and ligand discovery. PNA-encoding stands out for its compatibility with standard solid phase synthesis and the technology has been used to prepare libraries of peptides, heterocycles and glycoconjugates. Different screening formats have now been reported including selection-based and microarray-based methods that have yielded specific ligands against diverse target classes including membrane receptors, lectins and challenging targets such as Hsp70.
authors.affiliation: Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Zambaldo
authors.affiliation: Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland.
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.affiliation: Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, Geneva, Switzerland. Electronic address: nicolas.winssinger@unige.com.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D020650:Combinatorial Chemistry Techniques; D055808:Drug Discovery; D005456:Fluorescent Dyes / Q000737:chemistry; D015723:Gene Library; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D037102:Lectins / Q000737:chemistry; D008024:Ligands; D019151:Peptide Library; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D005456:Fluorescent Dyes; D006001:Glycoconjugates; D018840:HSP70 Heat-Shock Proteins; D006571:Heterocyclic Compounds; D037102:Lectins; D008024:Ligands; D019151:Peptide Library; D020135:Peptide Nucleic Acids; D054852:Small Molecule Libraries