title: 2,3-Dihydroquinazolin-4(1H)-ones: visible light mediated synthesis, solvatochromism and biological activity.
abstract: The photochemical synthesis of a series of 2,3-dihydroquinazolin-4(1H)-ones were evaluated under the irradiation of visible light (>390nm). The effect of the visible light mediated synthesis was carried out in the presence/absence of solvent. The effect of solvent plays a key role in the synthesis was evidenced through the formation of product in short duration. The solvatochromic effects of the fluorescent compounds (3a-k) were studied with respect to the solvents of increasing polarity (DCM<methanol<DMF<DMSO). The determination of in vitro anti-inflammatory activity of the compounds (3a-k) by the inhibition of bovine serum albumin (BSA) denaturation and 2,2-di(4-t-octylphenyl)-1-picrylhydrazyl (DOPPH) radical scavenging consequence of the compounds (3a-k) were determined by spectroscopic technique. The compound 3j in DMSO exhibited extreme high quantum yield. The compound 3i was found to be superior both in the efficiency of the anti-inflammatory activity and radical scavenging ability.
authors.affiliation: Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Hemalatha
authors.affiliation: Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address: dr.g.madhumitha@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Madhumitha
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Vasavi
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India.
authors.forename: Punnagai
authors.initials: P
authors.lastname: Munusami
mesh_terms: D000818:Animals; D002417:Cattle; D060326:Chemistry Techniques, Synthetic; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008027:Light; D062105:Molecular Docking Simulation; D055668:Photochemical Processes; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism; D011489:Protein Denaturation / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D011799:Quinazolines; D012997:Solvents; D012710:Serum Albumin, Bovine; D011065:Poly(ADP-ribose) Polymerases