title: Adenoid basal carcinoma-like tumor combined with invasive squamous cell carcinoma foci of uterine cervix - a case report of 55-year-old woman with literature review.
abstract: BACKGROUND
  Adenoid basal carcinoma (ABC) of uterine cervix is an extraordinary example of carcinoma with both basal and glandular cell types. Here we present such a case of ABC combined with invasive squamous cell carcinoma (SCC) of 55-year-old woman.
  
  
  METHODS
  The tumor was stained with Hematoxylin-Eosin (HE), Mucicarmine, PAS/Alcian Blue, CK AE1/AE3, CK7, CD117 and Ki67.
  
  
  RESULTS
  The whitish-grey 1 cm in-depth infiltration of endocervix was composed of infiltrative coalescing areas of CK AE1/AE3 positive carcinoma with peripheral palisading of basal cell type with spaces lined by Mucicarmine- and Alcian Blue-positive benign looking, glandular epithelium. There were also foci of apparently malignant squamous epithelium with evident dyskeratosis. Thus, a lesion was diagnosed of adenoid basal carcinoma combined with invasive squamous cell carcinoma foci of uterine cervix. The tumor was further CD117 negative what favored diagnosis of ABC over adenoid cystic carcinoma (ACC). There were rare mitoses on HE slides but 60% of all tumor cells were positive for Ki67 that would partially contradict reported benign nature of ABC lesion. Moreover, tumor was CK7-positive and this finding was controversial and according to one report favored diagnosis of ABC-like adenosquamous carcinoma (ACC). Due to CK7 positivity and high index of Ki67, the neoplasm was re-classified as adenoid basal carcinoma-like tumor.
  
  
  CONCLUSIONS
  It seems reasonable to treat the patient in the same manner as in case of pure simple invasive squamous cell carcinoma because much more aggressive, minor component of invasive SCC was found within ABC in our case.
authors.affiliation: Department of Anatomy, Faculty of Health Sciences, Jan Kochanowski Memorial University, Kielce, Poland; andwinc@gmail.com, ruahpolin@yahoo.com.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wincewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewitowicz
authors.forename: Sławka
authors.initials: S
authors.lastname: Urbaniak-Wąsik
authors.forename: Luiza
authors.initials: L
authors.lastname: Kanczuga-Koda
authors.forename: Mariusz
authors.initials: M
authors.lastname: Koda
authors.forename: Olga
authors.initials: O
authors.lastname: Adamczyk-Gruszka
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sulkowski
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology*