title: The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.
abstract: Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Stéphane
authors.identifier: 0000000186013598
authors.initials: S
authors.lastname: Cociancich
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Alexander
authors.identifier: 0000000253489810
authors.initials: A
authors.lastname: Pesic
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petras
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Uhlmann
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Kretz
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Vivien
authors.initials: V
authors.lastname: Schubert
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Vieweg
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Duplan
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Marguerettaz
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Noëll
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pieretti
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Hügelland
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kemper
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Andi
authors.initials: A
authors.lastname: Mainz
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rott
authors.affiliation: Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Royer
authors.affiliation: Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry*; D000409:Alanine / Q000031:analogs & derivatives* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000737:chemistry; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D014974:Xanthomonas / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D009930:Organic Chemicals; D059005:Topoisomerase II Inhibitors; C004631:3-cyanoalanine; C046156:albicidin; D000409:Alanine; D010129:4-Aminobenzoic Acid