title: [Ecthyma gangrenosum associated with infection involving a methicillin-sensitive, Panton-Valentine-negative strain of Staphylococcus aureus].
abstract: BACKGROUND
  Ecthyma gangrenosum (EG) is an anatomoclinical syndrome commonly associated with Pseudomonas aeruginosa cutaneous infection. Other microorganisms have also been incriminated on occasion, with other viral, fungal and bacterial agents potentially causing EG. In this report, we present an extremely rare case of an EG caused by methicillin-sensitive Staphylococcus aureus (MSSA) infection. This case, highly characteristic of EG both clinically and histologically, calls into question the physiopathological mechanisms of the disease and provides a reminder that it may be caused by a variety of organisms.
  
  
  METHODS
  A 62-year-old woman, followed for HIV seropositivity at the AIDS stage, developed a painful purpuric skin rash evolving towards necrotic nodules characteristic of ecthyma gangrenosum. Skin biopsy confirmed the diagnosis of EG due to methicillin-sensitive S. aureus (MSSA) infection without toxins or bacteraemia.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case in the literature in which MSSA is reported as the underlying cause of such lesions.
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Buffière-Morgado
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Demongeot
authors.affiliation: Anatomie pathologique, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Battistella
authors.affiliation: Maladies infectieuses, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Taieb
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Viguier
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Rybojad
authors.affiliation: Bactériologie, hospices civils de Lyon, 3, quai des Célestins, 69002 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Tristan
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Bagot
authors.affiliation: Dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: antoine.petit@sls.aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Petit
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000032:analysis; D001769:Blood / Q000382:microbiology; D003221:Confusion / Q000209:etiology; D004473:Ecthyma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005098:Exotoxins / Q000032:analysis; D005188:False Negative Reactions; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007956:Leukocidins / Q000032:analysis; D008712:Methicillin / Q000494:pharmacology*; D016106:Methicillin Resistance; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000737:chemistry / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D019980:Amoxicillin-Potassium Clavulanate Combination; D008712:Methicillin
keywords: Ecthyma gangreneux; Ecthyma gangrenosum; Methicillin-sensitive Staphylococcus aureus; Panton-Valentine; Panton-Valentine toxin; Staphylococcus aureus sensible à la méthicilline