title: [Randomized controlled trial of sodium phosphate tablets versus 2 L polyethylene glycol solution for bowel cleansing prior to colonoscopy].
abstract: OBJECTIVE
  Performance of polyethylene glycol solution (PEG) is often unsatisfactory as bowel preparation agent for colonoscopy. In order to provide equivalent efficacy with better patient tolerance, sodium phosphate tablet (SPT) has been developed. This study was carried out to compare the efficacy and compliance of two bowel preparation methods: PEG with ascorbic acid (PEGA) vs. SPT preparation.
  
  
  METHODS
  A multicenter, randomized controlled trial was performed. Primary efficacy variable was overall quality of colon cleansing assessed by Boston bowel preparation scale (BBPS) during colonoscopy. Patient's satisfaction and adverse events were evaluated by means of symptom questionnaire completed by each patient immediately before colonoscopy.
  
  
  RESULTS
  A total of 189 patients were randomly assigned to undergo pre-colonoscopic bowel preparation with either SPT (n = 96) or PEGA (n = 93). Overall BBPS score was 8.3 ± 1.12 in the SPT group and 8.4 ± 0.96 in the PEGA group (p = 0.441). Among the 189 patients, 90 had polyps (47.6%) and 50 had adenomas (26.5%). The polyp/adenoma detection rate was 54.2% (n = 52)/27.1% (n = 26) for SPT group and 40.9% (n = 38)/25.8% (n = 24) for PEGA group (p = 0.079 and 0.790, respectively). More number of patients were unable to take the prescribed dose of PEGA compared with the SPT regimen (8.6% vs. 2.0%, p = 0.045). Overall satisfaction score was 7.9 ± 1.63 in the SPT group and 7.4 ± 1.53 in the PEGA group (p = 0.022).
  
  
  CONCLUSIONS
  Degree of colon preparation, polyp/adenoma detection rate and adverse effect were similar between SPT group and PEGA group. Patient compliance and satisfaction were greater in the SPT group.
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Yun Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Seong Yeon
authors.initials: SY
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: You Sun
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Cheol Hun
authors.initials: CH
authors.lastname: Kwak
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Song I
authors.initials: SI
authors.lastname: Bae
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Seoul, Korea.
authors.forename: Jeong Seop
authors.initials: JS
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Su Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kook Lae
authors.initials: KL
authors.lastname: Lee
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000236:Adenoma / Q000473:pathology; D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002400:Cathartics / Q000009:adverse effects / Q000627:therapeutic use*; D003111:Colonic Polyps / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D017060:Patient Satisfaction; D010710:Phosphates / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011795:Surveys and Questionnaires
chemical_list: D002400:Cathartics; D010710:Phosphates; D011092:Polyethylene Glycols; D001205:Ascorbic Acid; C018279:sodium phosphate