title: Stress signaling: serotonin spreads systemic stress.
abstract: Cells respond to elevated temperatures through a well-characterized heat-shock response that enables short-term survival, long-term adaptation and mitigation of macromolecular damage. New work reveals a cell non-autonomous layer of stress-response regulation between neurons and the gonad involving serotonin.
authors.affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA. Electronic address: arjumand.ghazi@chp.edu.
authors.forename: Arjumand
authors.initials: A
authors.lastname: Ghazi
authors.affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA. Electronic address: todd.lamitina@chp.edu.
authors.forename: Todd
authors.initials: T
authors.lastname: Lamitina
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D018869:Heat-Shock Response; D012701:Serotonin / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D014157:Transcription Factors; D012701:Serotonin