title: A new start from ground zero?
abstract: It is pointed out that one of the main reasons of lack of real conceptual progress in the field may lie in the fact that questions concerning the biogenesis of macromolecules have never been asked or addressed in a proper way. We should start again research on the origin of life starting from "ground zero" and focusing on the prebiotic synthesis of ordered sequences of proteins and nucleic acids.
authors.affiliation: University of Rome3, Viale Guglielmo Marconi 446, Rome, 00146, Italy, luisi@mat.ethz.ch.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Luisi
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000096:biosynthesis* / Q000737:chemistry; D055162:Biocatalysis; D005075:Biological Evolution; D008954:Models, Biological; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000069497:Origin of Life; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism; D014176:Protein Biosynthesis; D011487:Protein Conformation; D017510:Protein Folding; D012995:Solubility; D014867:Water
chemical_list: D000596:Amino Acids; D009842:Oligopeptides; D014867:Water; D010447:Peptide Hydrolases