title: A "green" strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles.
abstract: Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.
authors.affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.
authors.forename: V
authors.initials: V
authors.lastname: Agostoni
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: P
authors.initials: P
authors.lastname: Horcajada
authors.affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.
authors.forename: M
authors.initials: M
authors.lastname: Noiray
authors.affiliation: Cyclolab Cyclodextrin R&D Laboratory Ltd., Budapest, Illatos ut 7, H-1097 Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Malanga
authors.affiliation: Department of Chemistry and Physics, University of Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Aykaç
authors.affiliation: Cyclolab Cyclodextrin R&D Laboratory Ltd., Budapest, Illatos ut 7, H-1097 Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Jicsinszky
authors.affiliation: Department of Chemistry and Physics, University of Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Vargas-Berenguel
authors.affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.
authors.forename: N
authors.initials: N
authors.lastname: Semiramoth
authors.affiliation: Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France.
authors.forename: S
authors.initials: S
authors.lastname: Daoud-Mahammed
authors.affiliation: Plate-forme d'Imagerie Cellulaire, IFR141-IPSIT, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, France.
authors.forename: V
authors.initials: V
authors.lastname: Nicolas
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: C
authors.initials: C
authors.lastname: Martineau
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: F
authors.initials: F
authors.lastname: Taulelle
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: J
authors.initials: J
authors.lastname: Vigneron
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: A
authors.initials: A
authors.lastname: Etcheberry
authors.affiliation: Institut Lavoisier, Université de Versailles St Quentin, UMR CNRS 8180, 45 avenue des Etats-Unis, 78035Versailles, France.
authors.forename: C
authors.initials: C
authors.lastname: Serre
authors.affiliation: 1] Institut Galien, Université Paris-Sud, UMR CNRS 8612, 92290 Chatenay Malabry, France [2] Institut de Sciences Moléculaires, Université Paris-Sud, UMR CNRS 8214, 91405 Orsay Cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Gref
mesh_terms: D000818:Animals; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity
chemical_list: D020099:Coated Materials, Biocompatible