title: The use of "2-octyl cyanoacrylate" as skin adhesive in pediatric and congenital cardiac surgery.
abstract: OBJECTIVE
  The aim of this paper was to evaluate the safety and cost-effectiveness of "2-octyl-cyanoacrylate" as skin adhesive in congenital heart surgery.
  
  
  METHODS
  From April 2010 to December 2011, we collected data from 300 patients who underwent cardiac surgery for congenital heart disease. We divided our population into 3 groups: group-1 (N.=100):"2-octyl-cyanoacrylate" has been used to replace the intra-dermal suture line; group-2 (N.=100):"2-octyl-cyanoacrylate" has been utilized as a barrier ("add-on measure") in addition to the intra-dermal suture line, group-3 (N.=100) with a standard intra-dermal suture line.
  
  
  RESULTS
  Median age of patients was 1.36 years. One-hundred and thirty-nine patients were younger than 12 months and 56 older than 16 years. There were 11 wound dehiscence (3.6%) (2 in group-1 and 9 in group-3, P=0.001) and 1 superficial wound infection (group-1). Six patients (2%) required surgical wound revision (2 in group-1 and 4 in group-3, P=NS). Wound complication was significantly associated to delayed sternal closure (3/12 patients, 25% versus 13/288 patients, 4.5%) (P=0.04). Median cost (intra-/postoperative) for wound treatment was lower in group-1 and 2 (19±5.5 and 23.9±7.4 € respectively) when compared to Group-3 (26.7±3.2) (P<0.0001).
  
  
  CONCLUSIONS
  The use of "2-octyl-cyanoacrylate" proved to be safe and effective; the "add-on measure" strategy provided the best cost-effective solution.
authors.affiliation: Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy - vladimirovida@yahoo.it.
authors.forename: V L
authors.initials: VL
authors.lastname: Vida
authors.forename: E
authors.initials: E
authors.lastname: Barzon
authors.forename: C
authors.initials: C
authors.lastname: Sabiu
authors.forename: M
authors.initials: M
authors.lastname: De Franceschi
authors.forename: M A
authors.initials: MA
authors.lastname: Padalino
authors.forename: G
authors.initials: G
authors.lastname: Stellin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D003487:Cyanoacrylates / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013529:Surgical Wound Dehiscence / Q000453:epidemiology; D014014:Tissue Adhesives / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D055815:Young Adult
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate