title: Total synthesis of a thromboxane receptor antagonist, terutroban.
abstract: A total synthesis of terutroban is achieved using the Claisen rearrangement, Friedel-Crafts acylation and Heck coupling as key reactions, avoiding the classical Diels-Alder approach used before.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India 500 007. srivaric@iict.res.in.
authors.forename: Wasim
authors.initials: W
authors.lastname: Ahmed
authors.forename: Prathama S
authors.initials: PS
authors.lastname: Mainkar
authors.forename: Srihari
authors.initials: S
authors.lastname: Pabbaraja
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
mesh_terms: D000475:Alkenes / Q000737:chemistry; D001792:Blood Platelets / Q000187:drug effects; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors*
chemical_list: D000475:Alkenes; D009281:Naphthalenes; D011422:Propionates; D017482:Receptors, Thromboxane; C501362:terutroban; D010100:Oxygen