title: Innate lymphoid cells involve in tumorigenesis.
abstract: Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-tumor immune-related function was recently demonstrated. In this review we discuss whether and how ILCs involve in the tumorigenesis, providing new insights into the mechanisms underlying the particular functions of ILCs as well as the potential targets for tumor intervention.
authors.affiliation: Institute of Immunology PLA, Third Military Medical University, Chongqing, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Tian
authors.affiliation: van Velkinburgh Initiative for Collaboratory BioMedical Research, Santa Fe, NM.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: van Velkinburgh
authors.affiliation: Institute of Immunology PLA, Third Military Medical University, Chongqing, China.
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Institute of Immunology PLA, Third Military Medical University, Chongqing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ni
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D010641:Phenotype
keywords: IL-17; IL-22; Th1; Th2; cancer; cytokine; innate lymphoid cells