title: Icetexane diterpenoids from Perovskia atriplicifolia.
abstract: Five new icetexane diterpenoids, namely, perovskatones B-D (1, 3, 4), 1α-hydroxybrussonol (2), and 1α-hydroxypisiferanol (5), were isolated from Perovskia atriplicifolia, together with a new natural product (6) and two known compounds, przewalskin E (7) and brussonol (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D, and 2D NMR data. Compounds 1-8 were assayed for their inhibitory hepatitis B virus activities in the HepG 2.2.15 cell line. The results suggested that compounds 1 and 2 possessed noticeable anti-hepatitis B virus activity in vitro, suppressing the replication of hepatitis B virus DNA with selectivity index values of 154.3 and 137.7, respectively.
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Yi-Jiang
authors.initials: YJ
authors.lastname: Yu
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Chao-Guan
authors.initials: CG
authors.lastname: Huang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.affiliation: Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming, Yunnan, China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Wang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Biotechnology, Yunnan Minzu University, Kunming, Yunnan, China.
authors.forename: Gan-Peng
authors.initials: GP
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D056945:Hep G2 Cells; D006509:Hepatitis B / Q000188:drug therapy / Q000821:virology; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D010936:Plant Extracts; C502780:brussonol; C512853:icetexone