title: Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients.
abstract: The impact of Parkinson's disease (PD) on psychological status and quality of life (QoL) may vary depending on age of disease onset. The aim of this study was to compare psychological symptoms and disease-specific QoL between early onset versus the rest of the PD patients. A total number of 140 PD patients with the mean current age of 61.3 (SD = 10.4) yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as "early-onset" (EOPD) group (n = 45), while the ones with >50 yr at the time of diagnosis were categorized as the "typical-onset" (TOPD) patients (n = 95). Different questionnaires and scales were used for between-group comparisons including PDQ39, HADS (hospital anxiety and depression scale), FSS (fatigue severity scale), MNA (mininutritional assessment), and the UPDRS. Depression score was significantly higher in EOPD group (6.3 (SD = 4.5) versus 4.5 (SD = 4.2), P = 0.02). Among different domains of QoL, emotion score was also significantly higher in the EOPD group (32.3 (SD = 21.6) versus 24.4 (SD = 22.7), P = 0.05). Our findings showed more severe depression and more impaired emotional domain of QoL in early-onset PD patients. Depression and anxiety play an important role to worsen QoL among both EOPD and TOPD patients, while no interaction was observed in the efficacy of these two psychiatric symptoms and the onset age of PD patients.
authors.affiliation: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran 15937-48711, Iran.
authors.forename: Seyed-Mohammad
authors.identifier: 0000-0001-9255-9351
authors.initials: SM
authors.lastname: Fereshtehnejad
authors.affiliation: Medical Student Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
authors.forename: Hasti
authors.initials: H
authors.lastname: Hadizadeh
authors.affiliation: Medical Student Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Farhadi
authors.affiliation: Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
authors.forename: Gholam Ali
authors.identifier: 0000-0002-3889-4973
authors.initials: GA
authors.lastname: Shahidi
authors.affiliation: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Iranian Research Center on Aging, University of Social Welfare and Rehabilitation, Tehran 19857-13834, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Delbari
authors.affiliation: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Department of Geriatric Medicine, Karolinska University Hospital, 14186 Stockholm, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Lökk