title: Influence of trans fat on skin damage in first-generation rats exposed to UV radiation.
abstract: The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first-generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C-SO, rich in n-6 FA; control group) or hydrogenated vegetable fat (HVF, rich in TFA) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl (PC) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR, the HVF group showed increased skin thickness and reactive species (RS) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR-induced disorders.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Raquel Cristine S
authors.initials: RC
authors.lastname: Barcelos
authors.forename: Luciana T
authors.initials: LT
authors.lastname: Vey
authors.forename: Hecson Jesser
authors.initials: HJ
authors.lastname: Segat
authors.forename: Dalila M
authors.initials: DM
authors.lastname: Benvegnú
authors.forename: Fabíola
authors.initials: F
authors.lastname: Trevizol
authors.forename: Karine
authors.initials: K
authors.lastname: Roversi
authors.forename: Katiane
authors.initials: K
authors.lastname: Roversi
authors.forename: Verônica T
authors.initials: VT
authors.lastname: Dias
authors.forename: Geisa S
authors.initials: GS
authors.lastname: Dolci
authors.forename: Fábio T
authors.initials: FT
authors.lastname: Kuhn
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Piccolo
authors.forename: Juliana
authors.initials: J
authors.lastname: CristinaVeit
authors.forename: Tatiana
authors.initials: T
authors.lastname: Emanuelli
authors.forename: Marilise E
authors.initials: ME
authors.lastname: Bürger
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006865:Hydrogenation; D008928:Mitochondria / Q000187:drug effects* / Q000528:radiation effects; D010938:Plant Oils / Q000008:administration & dosage*; D011247:Pregnancy; D050050:Protein Carbonylation / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D013024:Soybean Oil / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D010938:Plant Oils; D017382:Reactive Oxygen Species; D013024:Soybean Oil; D002374:Catalase; D013482:Superoxide Dismutase