title: Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids.
abstract: Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We report herein two cases of ovarian AGCT presenting with exfoliated tumor cells in pleural and ascitic fluid. The first case involved a 61-year-old woman who presented with stage Ic (a) AGCT. Seven years after initial diagnosis, pleural effusion and pleural dissemination were identified. The second case involved a 50-year-old woman who presented with stage IV AGCT with massive ascites and right pleural effusion. Fluid cytology from both cases showed cohesive or loose clusters of small uniform neoplastic cells with round-to-oval nuclei, coffee-bean-shaped nuclear grooves, small nucleoli, and scant cytoplasm. Call-Exner bodies were also observed in these cytologic specimens. In the differential diagnosis of small monomorphic tumor cells in pleural effusion or ascites, coffee-bean-shaped nuclear grooves and cell clusters forming Call-Exner bodies are diagnostic clues of AGCT.
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Omori
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yuminamochi
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakazawa
authors.affiliation: Department of Pathology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishii
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fukasawa
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hashi
authors.affiliation: Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Hirata
mesh_terms: D001202:Ascitic Fluid / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000473:pathology*; D035422:Pleural Cavity / Q000473:pathology; D010996:Pleural Effusion / Q000175:diagnosis* / Q000473:pathology
keywords: Call-Exner body; ascites; cytology; granulosa cell tumor; nuclear groove; ovarian neoplasm; pleural effusion