title: Do genes modify the association of selenium and lipid levels?
abstract: The interaction of selenium, a component of antioxidant selenoproteins, with genetic variation in lipid-related pathways has not been evaluated earlier as a potential determinant of blood lipid levels. We aimed at evaluating the effects of gene-environment interactions between plasma levels of selenium and polymorphisms in lipid metabolic pathways on plasma lipid levels in a study population from Spain (N=1,315). We observed statistically significant associations between plasma selenium and lipid levels (differences in total, low-density lipoprotein [LDL]-cholesterol, and triglycerides comparing the 80th with the 20th percentiles of plasma selenium levels were, respectively, 12.0 (95% confidence interval 6.3, 17.8), 8.9 (3.7, 14.2), and 9.0 (2.9, 15.2) mg/dl). We also found statistically significant interactions at the Bonferroni-corrected significance level (p=0.0008) between selenium and rs2290201 in FABP4 for total and LDL cholesterol levels and rs1800774 in CETP for elevated LDL cholesterol. Other polymorphisms showed statistically significant differential associations of plasma selenium levels and lipids biomarkers at the nominal p-value of 0.05. Reported statistical interactions with genes involved in lipid transport and transfer provide biological support to the positive associations of selenium with lipids shown in cross-sectional studies and lead to the hypothesis that selenium and lipid levels share common biological pathways that need to be elucidated in mechanistic studies.
authors.affiliation: 1 Genetic Diagnosis and Genotyping Unit, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA) , Valencia, Spain .
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Galan-Chilet
authors.forename: Eliseo
authors.initials: E
authors.lastname: Guallar
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Martin-Escudero
authors.forename: Griselda
authors.initials: G
authors.lastname: De Marco
authors.forename: Alejandro
authors.initials: A
authors.lastname: Dominguez-Lucas
authors.forename: Isabel
authors.initials: I
authors.lastname: Gonzalez-Manzano
authors.forename: Raul
authors.initials: R
authors.lastname: Lopez-Izquierdo
authors.forename: Josep
authors.initials: J
authors.lastname: Redon
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Chaves
authors.forename: Maria
authors.initials: M
authors.lastname: Tellez-Plaza
mesh_terms: D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012643:Selenium / Q000097:blood*; D015398:Signal Transduction; D013030:Spain; D014280:Triglycerides / Q000097:blood
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D008055:Lipids; D014280:Triglycerides; D012643:Selenium