title: Comparison of the prevalence of human papilloma virus infection in histopathologically confirmed premalignant oral lesions and healthy oral mucosa by brush smear detection.
abstract: OBJECTIVE
  The role of human papilloma virus (HPV) infections in oral carcinogenesis is an important topic of research in maxillofacial oncology. Nevertheless, the association between such infections in the oral cavity and the development of oral precancerous lesions remains unclear. The aim of this study was to evaluate the association between oral HPV infections and oral leukoplakia or erythroplakia.
  
  
  METHODS
  The case control study included 118 patients with manifest oral leukoplakia or erythroplakia, who underwent surgical biopsy, including a histopathologic grading of the lesion, and 100 control patients without any oral lesions. HPV detection was achieved with a noninvasive brush smear method (Digene Cervical Sampler, Hybrid Capture II-Test). Logistic regression analysis was performed to assess the associations.
  
  
  RESULTS
  A significant association was found between high-risk oral HPV infection and the presence of oral premalignant lesions (P = .001). Among all other evaluated parameters, only smoking showed a significant association with the presence of oral lesions.
  
  
  CONCLUSIONS
  Oral HPV infections may play a role in the pathogenesis of premalignant oral lesions.
authors.affiliation: University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria; Dental Clinic Dalla Torre, Jaufenstrasse, Sterzing, Italy. Electronic address: dr.dalla-torre@gmx.at.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dalla Torre
authors.affiliation: University Clinic of Prosthodontics, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
authors.forename: Doris
authors.initials: D
authors.lastname: Burtscher
authors.affiliation: Department of Medical Statistics, Informatics and Health Economics, Medical University Innsbruck, Schöpfstrasse, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Edlinger
authors.affiliation: University Clinic of Obstetrics and Gynecology, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sölder
authors.affiliation: University Clinic of Obstetrics and Gynecology, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Widschwendter
authors.affiliation: University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Rasse
authors.affiliation: University Clinic of Craniomaxillofacial Surgery, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Puelacher
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology / Q000821:virology*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires