title: [Update on genetic predisposition to prostate cancer].
abstract: Genetic predisposition to prostate cancer rarely corresponds to a high penetrance Mendelian pattern of inheritance. These hereditary forms are specific entities for which mutations in the BRCA2 gene, the HOXB13 gene (variant G84E) or, to a lesser extent BRCA1 gene, must be researched. In contrast, the genetic component of the majority of prostate cancer is polygenic, involving an unfavorable combination of common genetic variants, resulting from a mixture of the genetic inheritance of the father and the mother. One hundred of these genetic susceptibility variants have now been identified and validated. The main phenotypic trait associated with hereditary predisposition is the younger age at onset, which warrants special monitoring in order to stay in the window of curability at diagnosis. The psychological impact of a family history of prostate cancer or breast cancer favors the establishment of a dedicated monitoring and procedures for early diagnosis.
authors.affiliation: AP-HP, hôpital Tenon, service d'urologie, CeRePP, GHU Est, 4, rue de la Chine, 75970 Paris cedex 20, France; UPMC université Paris 06, GRC n(o) 5, Oncotype-Uro, Paris, France; Hôpital de la Salpêtrière, CeRePP, Paris, France. Electronic address: olivier.cussenot@tnn.aphp.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cussenot
authors.affiliation: UPMC université Paris 06, GRC n(o) 5, Oncotype-Uro, Paris, France; Hôpital de la Salpêtrière, CeRePP, Paris, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Cancel-Tassin
mesh_terms: D000367:Age Factors; D055088:Early Detection of Cancer; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology
chemical_list: C484414:HOXB13 protein, human; D018398:Homeodomain Proteins
keywords: BRCA2; Cancer de prostate; Dépistage; Genetic predisposition; Génétique; HOXB13; Hereditary; Héréditaire; Prostate cancer; Prédisposition; Susceptibility; Susceptibilité