title: Ratio of urine and blood urea nitrogen concentration predicts the response of tolvaptan in congestive heart failure.
abstract: OBJECTIVE
  This study was conducted to evaluate the performance of the ratio of urine and blood urea nitrogen concentration (UUN/BUN) as a new predictive factor for the response of an arginine vasopressin receptor 2 antagonist tolvaptan (TLV) in decompensated heart failure patients.
  
  
  METHODS
  This study enrolled 70 decompensated heart failure patients who were administered TLV at University of Tokyo Hospital. We collected the data of clinical parameters including UUN/BUN before administering TLV. Two different outcomes were defined as follows: having over 300 mL increase in urine volume on the first day (immediate urine output response) and having any decrease in body weight within one week after starting TLV treatment (subsequent clinical response).
  
  
  RESULTS
  Among the 70 enrolled patients, 37 patients (52.9%) showed immediate urine output response; 51 patients (72.9%) showed a subsequent clinical response of body weight decrease. Receiver operating characteristics (ROC) analysis showed good prediction by UUN/BUN for the immediate response (AUC-ROC 0.86 [0.75-0.93]) and a significantly better prediction by UUN/BUN for the subsequent clinical response compared with urinary osmolality (AUC-ROC 0.78 [0.63-0.88] vs. 0.68 [0.52-0.80], P < 0.05).
  
  
  CONCLUSIONS
  We demonstrated that a clinical parameter of UUN/BUN can predict the response of TLV even when measured before TLV administration. UUN/BUN might enable identification of good responders for this new drug.
authors.affiliation: Clinical Research Training Program, The University of Tokyo, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kent
authors.initials: K
authors.lastname: Doi
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Imamura
authors.forename: Eisei
authors.initials: E
authors.lastname: Noiri
authors.forename: Naoki
authors.initials: N
authors.lastname: Yahagi
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kinugawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D065092:Antidiuretic Hormone Receptor Antagonists / Q000627:therapeutic use*; D019540:Area Under Curve; D001552:Benzazepines / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001806:Blood Urea Nitrogen; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000652:urine; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D014041:Tokyo; D000077602:Tolvaptan; D016896:Treatment Outcome; D014508:Urea / Q000652:urine*; D014554:Urination / Q000187:drug effects; D055815:Young Adult
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D015415:Biomarkers; D000077602:Tolvaptan; D014508:Urea
keywords: body weight; diuretics; heart failure; urea nitrogen concentration; urine volume