title: Phenolic content, antioxidant and anti-inflammatory activities of Tunisian Diplotaxis simplex (Brassicaceae).
abstract: This study investigates the polyphenol content of Diplotaxis simplex extract and the biological activities of the main organ. The analysed extracts showed that polyphenol contents varied considerably as a function of organs. Furthermore, novel biological activities of this species were assessed. Flower extracts exhibit a potent in vitro antioxidant capacity using oxygen radical absorbance capacity and displayed a strong anti-inflammatory activity, inhibiting nitric oxide release, by 79.3% at 160 μg/mL. Our findings suggested that the Diplotaxis flower is a valuable source of antioxidants and anti-inflammatory agents.
authors.affiliation: a Laboratoire des Plantes Extêmophiles, Centre de Biotechnologie, Technopôle, de Borj-Cédria (CBBC) , BP 901, 2050 Hammam-Lif , Tunisia.
authors.forename: Samia
authors.initials: S
authors.lastname: Oueslati
authors.forename: Ahlem
authors.initials: A
authors.lastname: Ellili
authors.forename: Jean
authors.initials: J
authors.lastname: Legault
authors.forename: Andre
authors.initials: A
authors.lastname: Pichette
authors.forename: Riadh
authors.initials: R
authors.lastname: Ksouri
authors.forename: Mokhtar
authors.initials: M
authors.lastname: Lachaal
authors.forename: Najoua
authors.initials: N
authors.lastname: Karray-Bouraoui
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D019607:Brassicaceae / Q000737:chemistry*; D002460:Cell Line; D005419:Flavonoids / Q000737:chemistry; D035264:Flowers / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D044945:Proanthocyanidins / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D044945:Proanthocyanidins; D009569:Nitric Oxide
keywords: Diplotaxis simplex; anti-inflammatory activity; antioxidant activity; polyphenol content