title: [Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic patients].
abstract: OBJECTIVE
  To investigate the correlation between pro-B-type natriuretic peptide (NT-proBNP) and heart rate variability (HRV) in patients with diabetes.
  
  
  METHODS
  HRV and NT-proBNP levels were assessed in 58 patients with diabetes.The time domain and frequency domain indices and the level of NT-proBNP were compared between patients with normal and abnormal HRV, and the correlation of HRV index and NT-proBNP was analyzed.
  
  
  RESULTS
  The NT-proBNP level was significantly higher in patients with abnormal HRV than in those with normal HRV (320.2±88.3 vs 80.4±25.2 pg/ml, P<0.01).The level of NT-proBNP was negatively correlated with SDNN (r=-0.55, P<0.05), triangle index (r=-0.52, P<0.05), LF (r=-0.62, P<0.01), and VLF (r=-0.56, P<0.05).
  
  
  CONCLUSIONS
  NT-proBNP level is correlated with HRV, and an increased NT-proBNP indicates cardiac autonomic neuropathy in diabetic patients.
authors.affiliation: Department of Function Fourth People's Hospital of Shenzhen, Shenzhen 518000, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.forename: Xiao-Huan
authors.initials: XH
authors.lastname: Chen
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Wu
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Zhang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Chen
mesh_terms: D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain