title: HIV-1 replication and the cellular eukaryotic translation apparatus.
abstract: Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication.
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. santiago.guerrero@crg.eu.
authors.forename: Santiago
authors.initials: S
authors.lastname: Guerrero
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. j.batisse@ibmc-cnrs.unistra.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Batisse
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. c.libre@ibmc-cnrs.unistra.fr.
authors.forename: Camille
authors.initials: C
authors.lastname: Libre
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. s.bernacchi@ibmc-cnrs.unistra.fr.
authors.forename: Serena
authors.initials: S
authors.lastname: Bernacchi
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. r.marquet@ibmc-cnrs.unistra.fr.
authors.forename: Roland
authors.initials: R
authors.lastname: Marquet
authors.affiliation: Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France. jc.paillart@ibmc-cnrs.unistra.fr.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Paillart
mesh_terms: D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014176:Protein Biosynthesis; D014779:Virus Replication