title: Are CXCL13/CXCR5/FAK critical regulators of MSCs migration and differentiation?
abstract: Osteonecrosis of the femoral head is a common and challenging disease worldwide. The traditional treatments, such as core decompression procedure and joint replacement, are not satisfactory due to the limited outcome, repetitive surgery and cost. In recent years, autologous mesenchymal stem cells (MSCs) implantation into the femoral head has emerged as a promising method. The homing and differentiation of MSCs is determined by chemokines and their receptors, specific signals present in the micro-environment of the damaged tissue. CXCL13/CXCR5, highly expressed in the osteoblast and MSCs, are tissue specific and selectively migrate MSCs, thereafter triggering phosphorylation of focal adhesionkinase through mitogen-activated protein kinase pathway. Considering these characteristics, we hypothesize that CXCL13/CXCR5/FAK are critical signals in the trafficking and differentiation of MSCs.
authors.affiliation: Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China. Electronic address: njzhangyan2@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: drmachunhui@163.com.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: yyx511@sina.cn.
authors.forename: Yinxian
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Institute of Food and Nutraceutical Science, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: many@sjtu.edu.cn.
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: ycq3000@126.com.
authors.forename: Chengqing
authors.initials: C
authors.lastname: Yi
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D054382:Chemokine CXCL13 / Q000378:metabolism*; D005270:Femur Head / Q000166:cytology* / Q000473:pathology; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D010020:Osteonecrosis / Q000628:therapy*; D054380:Receptors, CXCR5 / Q000378:metabolism*
chemical_list: C095085:CXCR5 protein, human; D054382:Chemokine CXCL13; D054380:Receptors, CXCR5; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human