title: The Roles of Primary cilia in Polycystic Kidney Disease.
abstract: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders. These systemic disorders include abnormalities in cardiovascular, portal, pancreatic and gastrointestinal systems. ADPKD is considered to be among the ciliopathy diseases due to the association with abnormal primary cilia function. In order to understand the full course of primary cilia and its association with ADPKD, the structure, functions and role of primary cilia have been meticulously investigated. As a result, the focus on primary cilia has emerged to support the vital roles of primary cilia in ADPKD. The primary cilia have been shown to have not only a mechanosensory function but also a chemosensory function. Both structural and functional defects in primary cilia result in cystic kidney disease and vascular hypertension. Thus, the mechanosenory and chemosensory functions will be analyzed in regards to ADPKD.
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio ; College of Pharmacy, University of Baghdad, Baghdad, Iraq.
authors.forename: Sarmed H
authors.initials: SH
authors.lastname: Kathem
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Mohieldin
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
authors.forename: Surya M
authors.initials: SM
authors.lastname: Nauli
keywords: aneurysm; chemosensory; hypertension; renal epithelia; vascular endothelia