title: Serum sCD95L concentration in patients with spinal cord injury.
abstract: OBJECTIVE
  To determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury.
  
  
  METHODS
  Patients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4 h, 9 h, 12 h, 24 h, 3 days, 7 days, and 2, 4, 8 and 12 weeks postadmission. Serum concentrations of sCD95L were determined via immunoassay.
  
  
  RESULTS
  The study included 23 patients. Mean sCD95L concentrations were significantly lower at 4 h, 9 h, 12 h and 24 h than at admission, and were significantly higher at 8 and 12 weeks, compared with admission.
  
  
  CONCLUSIONS
  The serum sCD95L concentration fell significantly during the first 24 h after traumatic spinal cord injury. Concentrations then rose, becoming significantly higher than admission levels at 8 weeks. sCD95L may represent a possible therapeutic target for traumatic spinal cord injury.
authors.affiliation: BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Ludwigshafen, Germany.
authors.forename: Bahram
authors.initials: B
authors.lastname: Biglari
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany axel.buechler@gmx.de.
authors.forename: Axel
authors.initials: A
authors.lastname: Büchler
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Tyler
authors.initials: T
authors.lastname: Swing
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Child
authors.affiliation: BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Ludwigshafen, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Biehl
authors.affiliation: BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Ludwigshafen, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Reitzel
authors.affiliation: Institute for Medical Biometry and Informatics, University Hospital of Heidelberg, Heidelberg, Germany.
authors.forename: Tom
authors.initials: T
authors.lastname: Bruckner
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ferbert
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Korff
authors.affiliation: Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Rief
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Gerner
authors.affiliation: Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Arash
authors.initials: A
authors.lastname: Moghaddam
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004311:Double-Blind Method; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053222:Fas Ligand Protein
keywords: CD95 ligand; Spinal cord injury; neurological remission