title: Hypertension in adult Fabry's disease: is cardiotrophin-1 a diagnostic biomarker?
abstract: BACKGROUND
  Cardiotrophin-1 (CT-1), a cytokine produced by cardiomyocytes and non-cardiomyocytes in conditions of stress, can be used as a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients. Hypertension is one of the main adverse events in the third and last phase of Fabry's disease (FD). We measured CT-1 in order to examine its correlation with the vascular and cardiac alterations at different ages and assess its potential for use as a biomarker of hypertension in FD.
  
  
  RESULTS
  The level of CT-1 was clearly higher in hypertensive adults than in adult FD patients. FD patients show a small, non-significant decrease in plasma CT-1 with age, while in hypertensive patients CT-1 in plasma rises strongly and highly significantly with age.
  
  
  CONCLUSIONS
  CT-1 can be considered a good biomarker of the progression of hypertension with age, but particular care is needed when following hypertension in FD patients, since CT-1 does not correlate the same way with this disease.
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
authors.forename: Monica Gioia
authors.initials: MG
authors.lastname: Marazzi
authors.affiliation: Department of Biomedical, Surgical and Oral Sciences, Università degli Studi di Milano, Milan, Italy ; IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Galliera
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Vianello
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Dozio
authors.affiliation: Department of Sciences for Health, Università degli Studi di Milano - Bicocca, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Stella
authors.affiliation: IRCCS Policlinico San Donato, San Donato, Milano, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Tettamanti
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
authors.forename: Lorenza
authors.initials: L
authors.lastname: Tacchini
authors.affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy ; IRCCS Policlinico San Donato, San Donato, Milano, Italy.
authors.forename: Massimiliano M
authors.initials: MM
authors.lastname: Corsi Romanelli
keywords: Cardiotrophin-1 (CT-1); Fabry disease (FD); Hypertension