title: Mathematically guided approaches to distinguish models of periodic patterning.
abstract: How periodic patterns are generated is an open question. A number of mechanisms have been proposed--most famously, Turing's reaction-diffusion model. However, many theoretical and experimental studies focus on the Turing mechanism while ignoring other possible mechanisms. Here, we use a general model of periodic patterning to show that different types of mechanism (molecular, cellular, mechanical) can generate qualitatively similar final patterns. Observation of final patterns is therefore not sufficient to favour one mechanism over others. However, we propose that a mathematical approach can help to guide the design of experiments that can distinguish between different mechanisms, and illustrate the potential value of this approach with specific biological examples.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Tom W
authors.initials: TW
authors.lastname: Hiscock
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA megason@hms.harvard.edu.
authors.forename: Sean G
authors.initials: SG
authors.lastname: Megason
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D015509:Developmental Biology / Q000379:methods*; D004058:Diffusion; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018859:Hair Follicle / Q000196:embryology; D051379:Mice; D008954:Models, Biological; D012880:Skin Pigmentation / Q000502:physiology*; D015027:Zebrafish
keywords: Mathematical biology; Pattern formation; Periodic patterning; Pigment pattern; Reaction-diffusion; Turing