title: Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the prognostic role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and the need for para-aortic lymphadectomy in patients with primary fallopian tube carcinoma (PFTC).
  
  
  METHODS
  Ninety-one patients with a diagnosis of PFTC were identified through the gynecologic oncology service database of six academic centers. Clinicopathological, surgical, and complete blood count data were collected.
  
  
  RESULTS
  In univariate analysis, advanced stage, suboptimal surgery, and NLR > 2.7 were significant prognostic factors for progression-free survival, whereas in multivariate analysis, only advanced stage and suboptimal surgery were significant. In addition, in univariate analysis, cancer antigen 125 ≥ 35 U/mL, ascites, advanced stage, suboptimal surgery, NLR > 2.7, PLR > 233.3, platelet count ≥ 400,000 cells/mm(3), staging type, and histological subtype were significant prognostic factors for overall survival (OS); however, in multivariate analysis, only advanced stage, suboptimal surgery, NLR > 2.7, and staging type were significant. Inclusion of pelvic and para-aortic lymphadenectomy in surgery showed significant association with longer OS, with a mean and median OS of 42.0 months and 35.5 months (range, 22 to 78 months), respectively, vs. 33.5 months and 27.5 months (range, 14 to 76 months), respectively, for patients who underwent surgery without para-aortic lymphadenectomy (hazard ratio, 3.1; 95% confidence interval, 1.4 to 5.7; p=0.002).
  
  
  CONCLUSIONS
  NLR (in both univariate and multivariate analysis) and PLR (only in univariate analysis) were prognostic factors in PFTC. NLR and PLR are inexpensive and easy tests to perform. In addition, patients with PFTC who underwent bilateral pelvic and para-aortic lymphadenectomy had longer OS.
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Gungorduk
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Ibrahim E
authors.initials: IE
authors.lastname: Ertas
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Aykut
authors.initials: A
authors.lastname: Ozdemir
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Akkaya
authors.affiliation: Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey.
authors.forename: Elcin
authors.initials: E
authors.lastname: Telli
authors.affiliation: Department of Gynecologic Oncology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Taskin
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gokcu
authors.affiliation: Department of Gynecologic Oncology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Ahmet Baris
authors.initials: AB
authors.lastname: Guzel
authors.affiliation: Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey.
authors.forename: Tufan
authors.initials: T
authors.lastname: Oge
authors.affiliation: Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Akman
authors.affiliation: Department of Gynecologic Oncology, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Toptas
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Ulas
authors.initials: U
authors.lastname: Solmaz
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Askın
authors.initials: A
authors.lastname: Dogan
authors.affiliation: Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Mustafa Cosan
authors.initials: MC
authors.lastname: Terek
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Sanci
authors.affiliation: Department of Gynecologic Oncology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Ozsaran
authors.affiliation: Department of Gynecologic Oncology, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Tayyup
authors.initials: T
authors.lastname: Simsek
authors.affiliation: Department of Gynecologic Oncology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Vardar
authors.affiliation: Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey.
authors.forename: Omer Tarik
authors.initials: OT
authors.lastname: Yalcin
authors.affiliation: Department of Gynecologic Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Ozalp
authors.affiliation: Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Department of Gynecologic Oncology, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Firat
authors.initials: F
authors.lastname: Ortac
keywords: Neutrophil lymphocyte ratio; Platelet lymphocyte ratio; Primary fallopian tube carcinoma; Prognostic factor; Retroperitoneal lymphadenectomy