title: Etiopathogenetic, clinical and histopathological aspects regarding the involvement of dental focal infection in premature births with fetal hypotrophy.
abstract: The study conducted on a total of 1344 preterm births, of which 403 hypotrophic fetuses births (between 2010-2012 within the Maternal Clinics of Craiova, Romania), studied the involvement of dental inflammatory infections in the chorioamnionitis onset. The possibility of transferring germs, toxins and degraded materials into the blood flow, and them entering the chorioamniotic structures is quite a common issue. Subclinically often evolving chorioamniotic membrane and its existence is clearly established after birth by histopathological and bacteriological examinations, being partially responsible for the growth delay of the conception product. Our study revealed this fact, by using clinical examinations, ultrasound exams, bacteriological determinations of the amniotic fluid and the placenta, alongside the histopathological examinations. The chorioamnionitis inflammatory process is responsible for premature birth, through a high synthesis of interleukins (IL) and prostaglandins, causing uterine contractions. Our IL-6 dosage determinations show its growth that can be considered a prediction marker for preterm birth.
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; arnracaro@yahoo.com.
authors.forename: Gabriel Radu
authors.initials: GR
authors.lastname: Rîcă
authors.forename: Claudia Paula
authors.initials: CP
authors.lastname: Badi
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Rîcă
authors.forename: Carmen Mirela
authors.initials: CM
authors.lastname: Sîrbu
authors.forename: Nicolae
authors.initials: N
authors.lastname: Rîcă
mesh_terms: D000653:Amniotic Fluid / Q000382:microbiology; D005260:Female; D005491:Focal Infection, Dental / Q000382:microbiology* / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology* / Q000473:pathology*; D047928:Premature Birth / Q000382:microbiology* / Q000473:pathology*