title: [Regulative mechanisms of oxidative stress in kidney in diabetic nephropathy and interventional effects of Chinese herbal medicine].
abstract: In the development of diabetic nephropathy (DN), reactive oxygen specie (ROS) over much in vivo leads to oxidative stress(OS)-related renal injuries, which are characterized by the structural and functional changes in glomerular and renal tubular cells in morphology. The regulative approaches of OS involve the several signaling pathways, in which, both p38 mitogen-activated protein kinase (MAPK) signaling pathway and adenosine monophosphate-activated protein kinase (AMPK) signaling pathway play the important roles as the target of anti-oxidants. The interventional actions of Chinese herbal compound prescriptions and the extracts of single Chinese herbal medicine (CHM) on OS in the kidney in DN include regulating the balance between ROS and antioxidants, reducing the production of AGEs, inhibiting the expression of growth factors and intervening the activity of signaling pathways.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Mao
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Huang
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Wan
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Chen
authors.forename: Xi-Miao
authors.initials: XM
authors.lastname: Shi
authors.forename: Xian-Jie
authors.initials: XJ
authors.lastname: Meng
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal