title: The Danish Fetal Medicine Database: establishment, organization and quality assessment of the first trimester screening program for trisomy 21 in Denmark 2008-2012.
abstract: OBJECTIVE
  To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012.
  
  
  METHODS
  National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database.
  
  
  METHODS
  Pregnant women in Denmark undergoing first-trimester screening for trisomy 21.
  
  
  METHODS
  Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved.
  
  
  METHODS
  Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates.
  
  
  RESULTS
  A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period.
  
  
  CONCLUSIONS
  A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.
authors.affiliation: Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Charlotte K
authors.initials: CK
authors.lastname: Ekelund
authors.affiliation: Fetal Medicine Unit, Department of Obstetrics, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Olav B
authors.initials: OB
authors.lastname: Petersen
authors.affiliation: Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.|Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Finn S
authors.initials: FS
authors.lastname: Jørgensen
authors.affiliation: Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kjaergaard
authors.affiliation: Departments of Gynecology and Obstetrics, Holbaek Hospital, Holbaek, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Larsen
authors.affiliation: Kolding Hospital, Kolding, Denmark.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Olesen
authors.affiliation: Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.|Roskilde Hospital, Roskilde, Denmark.
authors.forename: Lillian
authors.initials: L
authors.lastname: Skibsted
authors.affiliation: Aalborg Hospital, Aalborg, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Skovbo
authors.affiliation: Horsens Hospital, Horsens, Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Sommer
authors.affiliation: Odense University Hospital, Odense, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Sperling
authors.affiliation: Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Benedicte
authors.initials: B
authors.lastname: Stavnstrup
authors.affiliation: Hjoerring Hospital, Hjoerring, Denmark.
authors.forename: Birgitte
authors.initials: B
authors.lastname: Størup
authors.affiliation: Fetal Medicine Unit, Department of Gynecology and Obstetrics, Herlev Hospital, Copenhagen, Denmark.
authors.forename: Helle
authors.initials: H
authors.lastname: Zingenberg
authors.affiliation: Fetal Medicine Unit, Department of Obstetrics, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Uldbjerg
authors.affiliation: Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Miltoft
authors.affiliation: Unit for Clinical Information and Data, Capitol Region, Copenhagen, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Noergaard
authors.affiliation: Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: Camilla B
authors.initials: CB
authors.lastname: Wulff
authors.affiliation: Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.|Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ann
authors.initials: A
authors.lastname: Tabor
mesh_terms: D035843:Biomedical Research; D016208:Databases, Factual; D003718:Denmark / Q000453:epidemiology; D004314:Down Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008403:Mass Screening; D010500:Perinatology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment
keywords: Screening first trimester; chromosomal abnormalities; detection of trisomy 21; national database; quality assessment