title: Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting.
abstract: OBJECTIVE
  We aim to compare the effects of propofol and dexmedetomidine infusions on extubation times, hemodynamic and respiratory functions, complication rates and patient satisfaction scores in patients undergoing coronary artery bypass graft (CABG) surgery using a fast-track anesthesia regimen for early extubation.
  
  
  METHODS
  We enrolled 64 patients who underwent CABG surgery. Dexmedetomidine (min 0.2 µg/kg/h-max 1.0 µg/kg/h) and propofol (min 1.0 mg/kg/h-max 3.0 mg/kg/h) infusion doses were titrated to give bispectral index values between 60 and 90 and a Ramsay sedation score (RSS) between 3 and 4. Postoperative extubation times, patient satisfaction and postoperative adverse events were recorded.
  
  
  RESULTS
  The mean times to extubation were 265.94 ± 43.1 min for the dexmedetomidine group and 322.52 ± 39.2 min for the propofol group (P < 0.001). In all recordings, RSS median values for the propofol group were significantly lower than the dexmedetomidine group (P < 0.05). There were no differences in the incidence of postoperative adverse events between the dexmedetomidine and propofol groups. There was a statistically significant difference between patient satisfaction median values of the two groups-7 (5-9) and 9 (7-10) (min-max) for the propofol and dexmedetomidine groups, respectively (P < 0.001).
  
  
  CONCLUSIONS
  Our results show that dexmedetomidine can easily be preferred over propofol in fast-track cardiac anesthesia due to its significant advantages of shorter extubation time and higher postoperative patient satisfaction scores.
authors.affiliation: Department of Anaesthesiology and Reanimation, Izmir Tepecik Research and Training Hospital, Izmir, Turkey.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Karaman
authors.forename: Burcin
authors.initials: B
authors.lastname: Abud
authors.forename: Zeki Tuncel
authors.initials: ZT
authors.lastname: Tekgul
authors.forename: Meltem
authors.initials: M
authors.lastname: Cakmak
authors.forename: Murside
authors.initials: M
authors.lastname: Yildiz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gonullu
mesh_terms: D000368:Aged; D060666:Airway Extubation; D000758:Anesthesia / Q000379:methods; D000762:Anesthesia Recovery Period; D001026:Coronary Artery Bypass / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D011997:Recovery Room; D012119:Respiration
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol