title: [Oct parameters as predictive factors for the visual outcome after ranibizumab therapy in neovascular age related macular degeneration].
abstract: OBJECTIVE
  To evaluate macular morphological parameters measured by spectral domain optical coherence tomography (SD-OCT) as predictive factors of visual outcome in patients with exudative age-related macular degeneration (AMD) treated with ranibizumab.
  
  
  METHODS
  A retrospective study was conducted on 47 patients diagnosed with exudative AMD and treated with intravitreal ranibizumab for twelve months. Central retinal thickness (CRT), extension and thickness of modifications secondary to neovascular process, and status of the bands corresponding to the external limiting membrane (ELM) and to the ellipsoid region of the photoreceptors (ISe) were evaluated by means of SD-OCT. The relationship between these variables and visual acuity was analyzed by statistical methods.
  
  
  RESULTS
  At the time of the diagnosis, preservation of ELM and ISe bands, and CRT were correlated with initial visual acuity. Twelve months later, CRT and visual acuity were independent parameters. Bivariate relationship analysis showed a correlation between final visual acuity and the following parameters: initial CRT, initial ISe and ELM status, and ISe and ELM integrity after loading dose. Multiple regression analysis indicated that initial visual acuity and ISe band status after loading dose have a predictive value for final visual acuity.
  
  
  CONCLUSIONS
  The status of ISe and ELM bands after twelve months of treatment with ranibizumab was associated with visual outcome. Initial visual acuity and status of the ISe band after loading dose are prognostic factors of final visual acuity.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España. Electronic address: alicia.valgreen@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Valverde-Megías
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Donate-López
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Gil-de-Bernabé
authors.affiliation: Departamento de Bioquímica y Biología Molecular I, Facultad de Biología, Universidad Complutense, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Megías-Fresno
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España; Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, España; Red Temática de Investigación Cooperativa en Oftalmología (RETICS), Instituto de Salud Carlos III, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: García-Feijoo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D011379:Prognosis; D000069579:Ranibizumab / Q000627:therapeutic use*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D000069579:Ranibizumab
keywords: Age-related macular degeneration; Antiangiogenic treatment; Degeneración macular asociada a la edad; Elipsoides; Ellipsoids; External limiting membrane; Fotorreceptores; Membrana limitante externa; Photoreceptors; Spectral-domain optical coherence tomography; Tomografía de coherencia óptica de dominio espectral; Tratamiento antiangiogénico