title: Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4.
abstract: A series of pyridine derivatives were synthesized as potential inhibitors of chemokine receptor type 4. This chemokine receptor has been linked to various disease pathways including HIV-1 proliferation, autoimmune disorders, inflammatory diseases, and cancer metastasis. The compounds were tested for activity using an affinity binding assay and an assay that tests the ability to inhibit cell invasion. Two hit compounds (2band2j) have been identified for further evaluation that inhibit cell invasion by at least 50% and have an effective concentration of less than 100 nM in the binding affinity assay. The structures of the synthesized compounds were confirmed by spectral data.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Suazette Reid
authors.initials: SR
authors.lastname: Mooring
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Theresa
authors.initials: T
authors.lastname: Gaines
authors.affiliation: Department of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Hyunsuk
authors.initials: H
authors.lastname: Shim
keywords: CXC chemokine receptor type 4 (CXCR4); anti-cancer; anti-inflammatory; pyridine derivatives