title: Synthesis and fluorescence properties of new ester derivatives of isothiazolo [4,5-b] pyridine.
abstract: A two new compounds with potential biologically active were synthesized: ethyl 4-(2H-4,6-dimethyl-3-oxo-2,3-dihydroisothiazolo [5,4-b] pyridin-2-yl) butanoate and ethyl 4-(2H-4,6-dimethyl-2,3-dihydroisothiazolo [5,4-b] pyridin-3-yloxy) butanoate. The structures of all of the newly formed compounds were identified by elemental analysis, FTIR and (1)H NMR. Their optical properties were studied in ethanol and n-hexane by UV-Vis absorption and fluorescence spectroscopy. The ground-state and excited-state properties were investigated using the density functional theory (DFT) and the time-dependent density functional theory (TDDFT) methods. The results showed differences between emission spectra in ethanol and n-hexane solution (solvatochromism) for both new compounds.
authors.affiliation: Department of Inorganic Chemistry, Wrocław Medical University, ul. Borowska 211A, 50-556, Wrocław, Poland, edward.krzyzak@umed.wroc.pl.
authors.forename: Edward
authors.initials: E
authors.lastname: Krzyżak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Śliwińska
authors.forename: Wiesław
authors.initials: W
authors.lastname: Malinka
mesh_terms: D060326:Chemistry Techniques, Synthetic; D004952:Esters; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D004952:Esters; D011725:Pyridines; D013844:Thiazoles; C023666:pyridine