title: Case series of patients with chronic foot ulcers treated with autologous platelet-rich plasma.
abstract: Treatment for patients with chronic wounds is entering a new era, and autologous platelet-rich plasma (PRP) is among the most promising treatments. PRP contains a concentration of platelets obtained by centrifuging the patient's blood. Because it contains fibrin and high concentrations of growth factors, PRP is known to promote wound healing. In this study, we present five patients with chronic foot ulcers successfully treated with PRP in our institution. The patients had various underlying diseases: diabetes (n = 2), peripheral arterial disease (n = 1), both diabetes and peripheral arterial disease (n = 1), and cutaneous polyarteritis nodosa (n = 1). Also, we provide a description of PRP's mechanisms, advantages, and limitations.
authors.affiliation: Department of Dermatology, National Center for Global Health and Medicine, Tokyo, Japan; Department of Dermatology, National Suruga Sanatorium, Shizuoka, Japan.
authors.forename: Rie R
authors.initials: RR
authors.lastname: Yotsu
authors.forename: Shotaro
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okochi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tamaki
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003424:Crohn Disease / Q000150:complications; D017719:Diabetic Foot / Q000628:therapy*; D016523:Foot Ulcer / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D010488:Polyarteritis Nodosa / Q000150:complications
keywords: chronic wound; cutaneous polyarteritis nodosa; diabetic foot ulcer; peripheral arterial disease; platelet-rich plasma; wound healing