title: High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation.
abstract: BACKGROUND
  It is well established that soy protein diets as well as aerobic exercise could promote antioxidant capacity and consequently reduce free radicals overproduction on brain. However, little is know regarding to the high-protein diets and high intensity exercise on oxidative stress production. The aim of this study was to analyse the effects of high-protein diets and high-intensity exercise (HIE) on brain oxidative stress markers.
  
  
  METHODS
  A total of 40 male Wistar rats were randomly distributed in 4 experimental groups (n=10): normal-protein or high-protein diets with or without HIE for an experimental period of 12 weeks. Main oxidative damage markers in brain such as thiobarbituric acid-reactive substances (TBARs) and protein carbonyl content (PCC) were assessed. In addition, brain manganese superoxide dismutase (Mn-SOD), cooper/ zinc superoxide dismutase (CuZn-SOD) and catalase (CAT) antioxidant enzymes activity, and protein level of Nuclear factor erythroid 2 related factor 2 (Nrf2) were measured.
  
  
  CONCLUSIONS
  Brain TBARs, PCC, tSOD, Mn-SOD, CuZn-SOD and CAT levels were higher in the high-protein compared to the normal-protein groups (all, p.
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. dcamiletti@ugr.es.
authors.forename: Daniel
authors.initials: D
authors.lastname: Camiletti-Moirón
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. virginiaparicio@ugr.es.
authors.forename: Virginia Arianna
authors.initials: VA
authors.lastname: Aparicio
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. enebot@ugr.es.
authors.forename: Elena
authors.initials: E
authors.lastname: Nebot
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. ln.medina@hotmail.com.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Medina
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. rosario.mzmz@gmail.com.
authors.forename: Rosario
authors.initials: R
authors.lastname: Martínez
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. kapravelou@ugr.es.
authors.forename: Garyfallia
authors.initials: G
authors.lastname: Kapravelou
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. anikiaf@gmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Andrade
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. jmporres@ugr.es.
authors.forename: Jesús María
authors.initials: JM
authors.lastname: Porres
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. mlopezj@ugr.es.
authors.forename: María
authors.initials: M
authors.lastname: López-Jurado
authors.affiliation: Department of Physiology. Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, The Joint Institute for Sport and Health. University of Granada. Spain.. paranda@ugr.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Aranda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D004044:Dietary Proteins