title: Onsite-effects of dual-hemisphere versus conventional single-hemisphere transcranial direct current stimulation: A functional MRI study.
abstract: We performed functional MRI examinations in six right-handed healthy subjects. During functional MRI scanning, transcranial direct current stimulation was delivered with the anode over the right primary sensorimotor cortex and the cathode over the left primary sensorimotor cortex using dual-hemispheric transcranial direct current stimulation. This was compared to a cathode over the left supraorbital area using conventional single-hemispheric transcranial direct current stimulation. Voxel counts and blood oxygenation level-dependent signal intensities in the right primary sensorimotor cortex regions were estimated and compared between the two transcranial direct current stimulation conditions. Our results showed that dual-hemispheric transcranial direct current stimulation induced greater cortical activities than single-hemispheric transcranial direct current stimulation. These findings suggest that dual-hemispheric transcranial direct current stimulation may provide more effective cortical stimulation than single-hemispheric transcranial direct current stimulation.
authors.affiliation: Department of Physical Therapy, Yeungnam College of Science & Technology, Daegu 705-703, Republic of Korea.
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Kwon
authors.affiliation: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 705-717, Republic of Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Jang
keywords: cortical activation; dual-hemispheric stimulation; functional MRI; neural regeneration; neuroimaging; primary sensorimotor cortex; regeneration; transcranial direct current stimulation