title: Conventional markers in determination of activity of sarcoidosis.
abstract: OBJECTIVE
  Currently, there are no objective criteria to determine sarcoidosis activity. The present study aimed to discover a sensitive serum marker that would determine the activity of sarcoidosis and can be used during disease follow-up.
  
  
  METHODS
  Forty-eight patients with sarcoidosis and twenty healthy volunteers as a control group were included in the study. On their control visits, the patients were divided into active and inactive groups based on their clinical, physiological, and radiological status. Angiotensin converting enzyme (ACE), adenosine deaminase (ADA), total IgE (T-IgE), C-reactive protein (CRP), serum amyloid-A (SAA), and soluble interleukin-2 receptor (sIL2R) serum levels and classical findings of activity were compared, and the utilization of these parameters as markers of activity was investigated.
  
  
  RESULTS
  Thirty-nine cases were female (female/male: 39/9) and the mean age was 44.29±10.9years. Thirty-seven cases were active and 11 cases were inactive. Serum ACE, ADA, sIL2R, and SAA levels were significantly higher while T-IgE levels were lower in the sarcoidosis cases. A comparison of the markers between active and inactive cases showed that only SAA was significantly higher (p<0.001). sIL2R was elevated in cases with extra-pulmonary involvement (p<0.014). The area under the curve value was rather high for ADA (0.98 CI: 0.96-1.0); it also had high sensitivity (93.8%) and specificity (100%), and therefore had the highest diagnostic value (96.6%).
  
  
  CONCLUSIONS
  The current study showed that SAA wil be helpfull for detecting the activity of srcoidosis, IL2R measurement in exploring the extra-pulmonary organ involvement.
authors.affiliation: Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Chest Diseases, Istanbul, Turkey. Electronic address: sinemgungor@hotmail.com.
authors.forename: Sinem
authors.initials: S
authors.lastname: Gungor
authors.affiliation: Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Immunology and Allergy, Istanbul, Turkey. Electronic address: zfozseker@gmail.com.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Ozseker
authors.affiliation: Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Chest Diseases, Istanbul, Turkey. Electronic address: Mrtyalcinsoy@yahoo.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Yalcinsoy
authors.affiliation: Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Department of Chest Diseases, Istanbul, Turkey. Electronic address: esenakkaya@yahoo.com.
authors.forename: Esen
authors.initials: E
authors.lastname: Akkaya
authors.affiliation: Istanbul University, Cerrahpaşa Medical Faculty, Department of Public Health, Istanbul, Turkey. Electronic address: alpincan@yahoo.fr.
authors.forename: Günay
authors.initials: G
authors.lastname: Can
authors.affiliation: Başkent University, Department of Biochemistry, Istanbul, Turkey. Electronic address: drhacereroglu@gmail.com.
authors.forename: Hacer
authors.initials: H
authors.lastname: Eroglu
authors.affiliation: Istanbul University, Istanbul Medical Faculty, Department of Biochemistry, Istanbul, Turkey. Electronic address: semgenc@hotmail.com.
authors.forename: Nilgün Sema
authors.initials: NS
authors.lastname: Genc
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012507:Sarcoidosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D000683:Serum Amyloid P-Component / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015375:Receptors, Interleukin-2; D000683:Serum Amyloid P-Component; D007073:Immunoglobulin E; D002097:C-Reactive Protein; D007703:Peptidyl-Dipeptidase A; D000243:Adenosine Deaminase
keywords: Adenosine deaminase (ADA); Angiotensin converting enzyme (ACE); Sarcoidosis; Sarcoidosis activity; Serum amyloid-A (SAA); Soluble interleukin-2 receptor (sIL2R)