title: Plant development. Genetic control of distal stem cell fate within root and embryonic meristems.
abstract: The root meristem consists of populations of distal and proximal stem cells and an organizing center known as the quiescent center. During embryogenesis, initiation of the root meristem occurs when an asymmetric cell division of the hypophysis forms the distal stem cells and quiescent center. We have identified NO TRANSMITTING TRACT (NTT) and two closely related paralogs as being required for the initiation of the root meristem. All three genes are expressed in the hypophysis, and their expression is dependent on the auxin-signaling pathway. Expression of these genes is necessary for distal stem cell fate within the root meristem, whereas misexpression is sufficient to transform other stem cell populations to a distal stem cell fate in both the embryo and mature roots.
authors.affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Brian C W
authors.initials: BC
authors.lastname: Crawford
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jared
authors.initials: J
authors.lastname: Sewell
authors.affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Greg
authors.initials: G
authors.lastname: Golembeski
authors.affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Carmel
authors.initials: C
authors.lastname: Roshan
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA. marty@ucsd.edu jeffalong@ucla.edu.
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Long
authors.affiliation: Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA. marty@ucsd.edu jeffalong@ucla.edu.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Yanofsky
mesh_terms: D017360:Arabidopsis / Q000196:embryology / Q000235:genetics; D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000494:pharmacology; D018519:Meristem / Q000166:cytology / Q000196:embryology*; D009154:Mutation; D063245:Plant Development / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D029681:Arabidopsis Proteins; C586527:At3g57670 protein, Arabidopsis; D007210:Indoleacetic Acids; D014157:Transcription Factors