title: Gonadotrophin replacement for induction of fertility in hypogonadal men.
abstract: Congenital hypogonadotrophic hypogonadism (CHH) is a rare form of infertility caused by deficient secretion or action of gonadotrophin-releasing hormone. There is no consensus regarding the optimal approach to fertility treatment in CHH men. In most cases, appropriate hormonal treatment with human chorionic gonadotrophin with or without follicle stimulating hormone will induce testicular development, spermatogenesis and fertility. Recent studies have examined sequential treatment with FSH pre-treatment to optimize fertility outcomes in severely affected CHH patients. This paper reviews historical and recent literature to summarize the current evidence on therapeutic approaches for CHH men seeking fertility.
authors.affiliation: Endocrinology, Diabetes and Metabolism Service of the Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland. Electronic address: andrew.dwyer@chuv.ch.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Dwyer
authors.affiliation: Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland; The Children's Hospital, Helsinki University Central Hospital (HUCH), Helsinki, Finland. Electronic address: Traivio@mappi.helsinki.fi.
authors.forename: Taneli
authors.initials: T
authors.lastname: Raivio
authors.affiliation: Endocrinology, Diabetes and Metabolism Service of the Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Faculty of Biology & Medicine, Institute of Physiology and the Endocrinology, Diabetes and Metabolism Service of the Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne, Switzerland. Electronic address: nelly.pitteloud@chuv.ch.
authors.forename: Nelly
authors.initials: N
authors.lastname: Pitteloud
mesh_terms: D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000172:deficiency; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000151:congenital / Q000188:drug therapy*; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D016896:Treatment Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone
keywords: GnRH deficiency; Kallmann syndrome; fertility outcomes; fertility treatment; gonadotrophin therapy; hypogonadotrophic hypogonadism; male fertility