title: AhR expression and polymorphisms are associated with risk of coronary arterial disease in Chinese population.
abstract: The aryl hydrocarbon receptor (AhR) mediates the control of environmental toxicity, and modulates the development and pathogenesis of the cardiovascular system. However, little is known about the role of AhR in coronary arterial disease (CAD) susceptibility. We therefore conducted a case-control study in a Chinese population, and assessed the potential association between AhR variants and CAD susceptibility. Compared with the controls, circulating AhR expression was found to be significantly increased in patients with CAD and its subtypes including ST-segment and non-ST-segment elevation myocardial infarction, and stable and unstable angina pectoris. Receiver operating characteristic (ROC) analysis to evaluate the effect of AhR on CAD progression showed it to be a potent biomarker for CAD. Genotype frequencies of AhR rs2066853 differed significantly between CAD and control subjects, while smoking and hyperlipidemia markedly promoted CAD risk relative to the AhR polymorphism. Moreover, a significant difference in AhR variant distribution was observed between the four CAD subtypes with different severities. The expression level and functional polymorphisms of circulating AhR may affect the susceptibility and progression of CAD in Chinese populations. This provides a novel view of the etiology and epidemiology of CAD, and will contribute to the diagnosis and therapy of this severe disease.
authors.affiliation: 1] Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China [2] Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Shian
authors.initials: S
authors.lastname: Huang
authors.affiliation: Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Shui
authors.affiliation: Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Guoming
authors.initials: G
authors.lastname: Li
authors.affiliation: 1] Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China [2] Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lei
authors.affiliation: 1] Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China [2] Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Can
authors.initials: C
authors.lastname: Chen
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018336:Receptors, Aryl Hydrocarbon / Q000097:blood / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018336:Receptors, Aryl Hydrocarbon