title: Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis.
abstract: A myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation. It was concluded that both venoms present neurotoxic activity as a consequence of their crotoxin content. Furthermore, crotoxin from C.d. cumanensis is more potent than that from C.d. ruruima venom. At the concentration range in which both venoms express neurotoxic activity, only C.d. cumanensis venom also manifest a direct myotoxic effect that probably involves the synergic participation of other components than crotoxin.
authors.affiliation: São Paulo State University, Bioscience Institute of Botucatu, Botucatu, SP, Brazil.
authors.forename: Walter Luís Garrido
authors.initials: WL
authors.lastname: Cavalcante
authors.affiliation: University of Campinas, Biological Institute, Campinas, SP, Brazil.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Ponce-Soto
authors.affiliation: University of Campinas, Biological Institute, Campinas, SP, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Marangoni
authors.affiliation: São Paulo State University, Bioscience Institute of Botucatu, Botucatu, SP, Brazil. Electronic address: gallacci@ibb.unesp.br.
authors.forename: Márcia
authors.initials: M
authors.lastname: Gallacci
mesh_terms: D000818:Animals; D003435:Crotalid Venoms / Q000633:toxicity*; D017839:Crotalus / Q000378:metabolism*; D003439:Crotoxin / Q000633:toxicity*; D003964:Diaphragm / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D009465:Neuromuscular Agents / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D003435:Crotalid Venoms; D009465:Neuromuscular Agents; D003439:Crotoxin
keywords: Crotalus subspecies; Neuromuscular transmission; Neurotoxin; Snake venom