title: Classification of Alzheimer Diagnosis from ADNI Plasma Biomarker Data.
abstract: Research into modeling the progression of Alzheimer's disease (AD) has made recent progress in identifying plasma proteomic biomarkers to identify the disease at the pre-clinical stage. In contrast with cerebral spinal fluid (CSF) biomarkers and PET imaging, plasma biomarker diagnoses have the advantage of being cost-effective and minimally invasive, thereby improving our understanding of AD and hopefully leading to early interventions as research into this subject advances. The Alzheimer's Disease Neuroimaging Initiative* (ADNI) has collected data on 190 plasma analytes from individuals diagnosed with AD as well subjects with mild cognitive impairment and cognitively normal (CN) controls. We propose an approach to classify subjects as AD or CN via an ensemble of classifiers trained and validated on ADNI data. Classifier performance is enhanced by an augmentation of a selective biomarker feature space with principal components obtained from the entire set of biomarkers. This procedure yields accuracy of 89% and area under the ROC curve of 94%.
authors.affiliation: Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Jue
authors.initials: J
authors.lastname: Mo
authors.affiliation: Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Maudsley
authors.affiliation: Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: Bronwen
authors.initials: B
authors.lastname: Martin
authors.affiliation: Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: Sana
authors.initials: S
authors.lastname: Siddiqui
authors.affiliation: Div. of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Huey
authors.initials: H
authors.lastname: Cheung
authors.affiliation: Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Calvin A
authors.initials: CA
authors.lastname: Johnson
keywords: Alzheimer’s Disease Neuroimaging Initiative (ADNI); feature augmentation; feature clustering