title: Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma.
abstract: FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-β1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape.
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Peng
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
authors.forename: Xuejia
authors.initials: X
authors.lastname: Lu
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
authors.forename: Xiwei
authors.initials: X
authors.lastname: Ding
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China. Electronic address: 13770771661@163.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zou
authors.affiliation: The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China. Electronic address: zhangxiaoqinj@163.com.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000276:immunology* / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000276:immunology* / Q000473:pathology; D018281:Cholangiocarcinoma / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D015536:Down-Regulation / Q000276:immunology; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology*; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000276:immunology; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Cholangiocarcinoma; FOXP3; Immune escape; Invasion