title: [Prognostic significance of CXCR2 expression in pancreatic ductal carcinoma].
abstract: OBJECTIVE
  To explore the relationship between the expression of CXC chemokine receptor 2 (CXCR2) and the clinicopathologic features with prognosis in pancreatic ductal carcinoma (PDAC) tissues.
  
  
  METHODS
  The CXCR2 expression in 161 PDAC tissues were detected with immunohistochemistry using anti-human CXCR2 antibody and tissues microarray.
  
  
  RESULTS
  The expression of CXCR2 in PDAC tumor tissues was higher than that in normal pancreatic tissues (χ(2) = 11.437, P = 0.001). The comparison of clinicopathologic characteristics and immunohistochemistry by χ(2) test analysis showed that a high expression of CXCR2 in PDAC was correlated with vascular invasion (χ(2) = 6.489, P = 0.011) and late TNM stage (χ(2) = 6.205, P = 0.013). Kaplan-Meier survival and Cox regression analyses showed that a high expression of CXCR2 (HR: 5.514, P = 0.016) was an independent prognostic factor.
  
  
  CONCLUSIONS
  A high expression of CXCR2 denotes a poor prognosis in PDAC.
authors.affiliation: First Affiliated Hospital, Soochow University, Suzhou 215006, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wang
authors.forename: Jinyu
authors.initials: J
authors.lastname: Zheng
authors.forename: Qichao
authors.initials: Q
authors.lastname: Ni
authors.forename: Huijun
authors.initials: H
authors.lastname: Zhu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Email: qianhaixin1@hotmail.com.
authors.forename: Haixin
authors.initials: H
authors.lastname: Qian
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D021441:Carcinoma, Pancreatic Ductal; D006801:Humans; D007150:Immunohistochemistry; D010190:Pancreatic Neoplasms; D011379:Prognosis; D023063:Receptors, Interleukin-8B
chemical_list: D023063:Receptors, Interleukin-8B