title: Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
abstract: We aimed to investigate the role of cathepsin D, an inflammatory and atherosclerotic mediator, in endothelial dysfunction in chronic kidney disease. The study included 65 patients with stage 2&ndash;4 chronic kidney disease (35 females, 30 males; mean age, 55.8&plusmn;15.6 years). Serum creatinine and cathepsin D levels and glomerular filtration rates (GFRs) were determined, and brachial flow-mediated dilation (FMD) percentage was measured by two-dimensional gray scale and color flow Doppler and vascular imaging. FMD &le;6% was considered to indicate endothelial dysfunction. Mean GFR, median creatinine levels, and median cathepsin D levels were 40.2&plusmn;11.2mL/min/1.73m2, 1.7mg/dL, and 819.75ng/mL, respectively. Endothelial dysfunction was present in 30 of the 65 patients (46.2%). There was a significant difference between groups with and without endothelial dysfunction in terms of cathepsin D (p=0.001) and creatinine (p=0.03) levels, and negative and significant correlations were found between brachial artery FMD% and cathepsin D (r=&minus;0.359, p=0.003) and creatinine (r=&minus;0.304, p=0.014) levels. Cathepsin D, which is known to be associated with atherosclerosis, may play a role in the process of endothelial dysfunction. Further studies are essential to determine the exact function of cathepsin D in endothelial dysfunction in chronic kidney disease and to determine its value as a tool for early diagnosis and target for treatment of cardiovascular diseases in patients with chronic kidney disease.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.forename: Serhan
authors.initials: S
authors.lastname: Piskinpasa
authors.forename: Fatma
authors.initials: F
authors.lastname: Akyel
authors.forename: Didem
authors.initials: D
authors.lastname: Turgut
authors.forename: Mesudiye
authors.initials: M
authors.lastname: Bulut
authors.forename: Turan
authors.initials: T
authors.lastname: Turhan
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology; D001916:Brachial Artery; D002402:Cathepsin D / Q000097:blood* / Q000502:physiology; D003404:Creatinine / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000503:physiopathology; D014664:Vasodilation
chemical_list: D003404:Creatinine; C533922:CTSD protein, human; D002402:Cathepsin D