title: Microbiota that affect risk for shigellosis in children in low-income countries.
abstract: Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.
authors.forename: Brianna
authors.initials: B
authors.lastname: Lindsay
authors.forename: Joe
authors.initials: J
authors.lastname: Oundo
authors.forename: M Anowar
authors.initials: MA
authors.lastname: Hossain
authors.forename: Martin
authors.initials: M
authors.lastname: Antonio
authors.forename: Boubou
authors.initials: B
authors.lastname: Tamboura
authors.forename: Alan W
authors.initials: AW
authors.lastname: Walker
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Paulson
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
authors.forename: Richard
authors.initials: R
authors.lastname: Omore
authors.forename: Abu S G
authors.initials: AS
authors.lastname: Faruque
authors.forename: Suman Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Usman N
authors.initials: UN
authors.lastname: Ikumapayi
authors.forename: Mitchell
authors.initials: M
authors.lastname: Adeyemi
authors.forename: Doh
authors.initials: D
authors.lastname: Sanogo
authors.forename: Debasish
authors.initials: D
authors.lastname: Saha
authors.forename: Samba
authors.initials: S
authors.lastname: Sow
authors.forename: Tamer H
authors.initials: TH
authors.lastname: Farag
authors.forename: Dilruba
authors.initials: D
authors.lastname: Nasrin
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Sandra
authors.initials: S
authors.lastname: Panchalingam
authors.forename: Myron M
authors.initials: MM
authors.lastname: Levine
authors.forename: Karen
authors.initials: K
authors.lastname: Kotloff
authors.forename: Laurence S
authors.initials: LS
authors.lastname: Magder
authors.forename: Laura
authors.initials: L
authors.lastname: Hungerford
authors.forename: Halvor
authors.initials: H
authors.lastname: Sommerfelt
authors.forename: Mihai
authors.initials: M
authors.lastname: Pop
authors.forename: James P
authors.initials: JP
authors.lastname: Nataro
authors.forename: O Colin
authors.initials: OC
authors.lastname: Stine
mesh_terms: D000367:Age Factors; D044822:Biodiversity; D016022:Case-Control Studies; D002675:Child, Preschool; D003906:Developing Countries; D003967:Diarrhea / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D004405:Dysentery, Bacillary / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D005243:Feces / Q000382:microbiology / Q000821:virology; D041981:Gastrointestinal Tract / Q000382:microbiology / Q000821:virology; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D054892:Metagenome; D064307:Microbiota; D016017:Odds Ratio; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012306:Risk; D012720:Severity of Illness Index; D012760:Shigella / Q000145:classification / Q000235:genetics*
chemical_list: D012336:RNA, Ribosomal, 16S