title: Biological Marker Analysis as Part of the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer.
abstract: The aim of the Clinical and Molecular Staging of Stage I-IIp Lung Cancer Project is to identify molecular variables that improve the prognostic and predictive accuracy of TMN classification in stage I/IIp non-small cell lung cancer (NSCLC). Clinical data and lung tissue, tumor and blood samples will be collected from 3 patient cohorts created for this purpose. The prognostic protein signature will be validated from these samples, and micro-RNA, ALK, Ros1, Pdl-1, and TKT, TKTL1 y G6PD expression will be analyzed. Tissue inflammatory markers and stromal cell markers will also be analyzed. Methylation of p16, DAPK, RASSF1a, APC and CDH13 genes in the tissue samples will be determined, and inflammatory markers in peripheral blood will also be analyzed. Variables that improve the prognostic and predictive accuracy of TNM in NSCLC by molecular staging may be identified from this extensive analytical panel.
authors.affiliation: Servicio de Neumología Hospital Universitari Parc Taulí, Sabadell, España; CIBER de Enfermedades Respiratorias-CIBERES, Instituto de Salud Carlos III, Madrid, España. Electronic address: emonso@tauli.cat.
authors.forename: Eduard
authors.initials: E
authors.lastname: Monsó
authors.affiliation: Programa de Patogénesis de Tumores Sólidos, Laboratorio de Biomarcadores, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Grupo RTICC RD12/0036/0040, Pamplona, España; Departamentos de Histología y Anatomía Patológica, Facultades de Medicina y Ciencias, Universidad de Navarra, Pamplona, España.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Montuenga
authors.affiliation: CIBER de Enfermedades Respiratorias-CIBERES, Instituto de Salud Carlos III, Madrid, España; Servicio de Neumología, Hospital San Pedro de Alcántara, Cáceres, España.
authors.forename: Julio
authors.initials: J
authors.lastname: Sánchez de Cos
authors.affiliation: CIBER de Enfermedades Respiratorias-CIBERES, Instituto de Salud Carlos III, Madrid, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Villena
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D015331:Cohort Studies; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D012107:Research Design
keywords: Adenocarcinoma; Biobanco; Biobank; Carcinoma escamoso; Cáncer de pulmón no célula pequeña; Estadificación molecular; Molecular staging; Non-small cell lung cancer; Squamous cell carcinoma