title: The role of dietary and lifestyle factors in the development of colorectal cancer: case control study in Minia, Egypt.
abstract: BACKGROUND
  Colorectal cancer (CRC) is the third most common cancer worldwide, after lung and breast cancer, and is associated with the population dietary and lifestyle factors.
  
  
  OBJECTIVE
  To determine the relation between dietary and lifestyle factors and development of CRC in patients attending Minia oncology centre and compare them with their control.
  
  
  METHODS
  Study included 150 CRC patients attending Minia oncology centre and 300 control subjects matched by age and sex. Subjects participating in the study filled in a questionnaire including questions about socio-demographic data, medical data concerning CRC and its treatment as well as dietary and lifestyle factors.
  
  
  RESULTS
  The most significant dietary and lifestyle CRC risk factors were higher consumption of red meat (OR = 57.1), preserved food (OR = 39.4), artificial sweeteners (OR = 20.8), fast foods (OR = 12.8), soft drinks (OR = 4.6), spicy foods (OR = 4.2), processed meat (OR = 2.4), and smoking (OR = 8.8). The most significant protective factors were physical activity (OR = 0.001), calcium rich diet (OR = 0.08), higher consumption of fruits and vegetable (OR = 0.02), cruciferous vegetables (broccoli OR = 0.11, cauliflower OR = 0.30 and cabbage OR = 0.30), high fiber bread (OR = 0.15), fruit juice (OR = 0.18), and sea foods (tuna OR = 0.28 and fish OR = 0.38).
  
  
  CONCLUSIONS
  Sedentary lifestyle and unhealthy dietary choices were prevalent among CRC cases. This study provides strong evidence that lifestyle and dietary modification are important factors in the prevention of colorectal cancer.
authors.forename: Eman Mohamed
authors.initials: EM
authors.lastname: Mahfouz
authors.forename: Refaat Raouf
authors.initials: RR
authors.lastname: Sadek
authors.forename: Wafaa Mohamed
authors.initials: WM
authors.lastname: Abdel-Latief
authors.forename: Fadia Abdel-Hamed
authors.initials: FA
authors.lastname: Mosallem
authors.forename: Ebtesam Esmail
authors.initials: EE
authors.lastname: Hassan
mesh_terms: D000328:Adult; D001837:Body Weights and Measures; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004032:Diet; D004534:Egypt / Q000453:epidemiology; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012111:Residence Characteristics; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D012959:Socioeconomic Factors