title: Recent insights into Groucho co-repressor recruitment and function.
abstract: Gene expression is often controlled by transcriptional repressors during development. Many transcription factors lack intrinsic repressive activity but recruit co-factors that inhibit productive transcription. Here we discuss new insights and models for repression mediated by the Groucho/Transducin-Like Enhancer of split (Gro/TLE) family of co-repressor proteins.
authors.affiliation: a Department of Genetics, Evolution and Environment ; University College London ; London , United Kingdom.
authors.forename: Aamna K
authors.initials: AK
authors.lastname: Kaul
authors.forename: Eugene F
authors.initials: EF
authors.lastname: Schuster
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Jennings
mesh_terms: D000818:Animals; D056970:Co-Repressor Proteins / Q000378:metabolism*; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D056970:Co-Repressor Proteins; D012097:Repressor Proteins; C498445:TLE5 protein, human
keywords: CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat; ChIP-seq, chromatin immunoprecipitation followed by high throughput sequencing, qPCR, quantitative PCR; Drosophila; Drosophila, Drosophila melanogaster, Gro, Groucho; E(spl), enhancer of split; GAF, GAGA Factor; NELF, Negative Elongation Factor; Gro/TLE, Groucho/Transducin-like enhancer of split; Groucho/TLE; P-TEFb, Positive Elongation Factor b; RNA polymerase pausing; RNAP II, RNA polymerase II; TALENs, Transcription Activator-Like Effector Nucleases; TSS, transcription start site; bHLH, basic helix-loop-helix; kb, kilobase; repressor; transcription factor; transcriptional repression