title: Effect of perioperative blood transfusion on mortality for major urologic malignancies.
abstract: BACKGROUND
  Patients who undergo surgical treatment for malignancy often receive perioperative blood transfusion (PBT). We examined the association between PBT and mortality in patients who received surgical treatment of prostate, bladder, and kidney cancer.
  
  
  METHODS
  Using the Surveillance, Epidemiology, and End Results-Medicare data set from 1992-2009, we identified 28,854 men with prostate cancer, 5462 patients with bladder cancer, and 14,379 patients with renal cell carcinoma who underwent radical prostatectomy (RP), radical cystectomy (RC), or radical (RN) or partial nephrectomy (PN) as primary therapy. Univariate and multivariate models were used to evaluate the association of PBT with cancer-specific mortality (CSM) and all-cause mortality (ACM).
  
  
  RESULTS
  The rate of PBT in bladder and kidney cancer have been increasing over time, and PBT in prostate cancer steadily increased and peaked in 2002 and declined afterward. The median follow-up for the RP, RC, and RN/PN cohorts were 70 months, 21 months, and 39 months, respectively. In the RP cohort, PBT was associated with greater CSM (hazard ratio [HR], 1.609; 95% confidence interval [CI], 1.235-2.097; P = .0004) and ACM (HR, 1.121; 95% CI, 1.006-1.251; P = .0394). In the RC cohort, PBT was not associated with greater CSM (HR, 1.047; 95% CI, 0.917-1.195; P = .4962) or ACM (HR, 1.095; 95% CI, 0.998-1.200; P = .0547). In the nephrectomy cohort, PBT was associated with greater CSM (HR, 1.365; 95% CI, 1.167-1.597; P = .0001) and ACM (HR, 1.402; 1.273-1.544; P < .0001).
  
  
  CONCLUSIONS
  PBT was associated with increased CSM and ACM for prostate and kidney cancer in a multivariate model. Although these data do not identify a causative relationship between PBT and mortality, efforts made to limit PBT in patients who undergo urologic cancer surgery can yield long-term survival benefits.
authors.affiliation: Department of Urology, University of Minnesota, Minneapolis, MN.
authors.forename: Ayman
authors.initials: A
authors.lastname: Soubra
authors.affiliation: Department of Urology, University of Minnesota, Minneapolis, MN.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Zabell
authors.affiliation: Department of Urology, University of Minnesota, Minneapolis, MN.
authors.forename: Oluwakayode
authors.initials: O
authors.lastname: Adejoro
authors.affiliation: Department of Urology, University of Minnesota, Minneapolis, MN. Electronic address: brkonety@umn.edu.
authors.forename: Badrinath R
authors.initials: BR
authors.lastname: Konety
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion / Q000401:mortality* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000401:mortality / Q000601:surgery*; D008297:Male; D019990:Perioperative Care; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality / Q000601:surgery*; D012307:Risk Factors; D018426:SEER Program; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000401:mortality / Q000601:surgery*
keywords: Bladder cancer; Blood Transfusion; Cancer Specific Mortality; Kidney cancer; Overall Mortality; Prostate cancer