title: Detecting neuroimaging biomarkers for schizophrenia: a meta-analysis of multivariate pattern recognition studies.
abstract: Multivariate pattern recognition approaches have recently facilitated the search for reliable neuroimaging-based biomarkers in psychiatric disorders such as schizophrenia. By taking into account the multivariate nature of brain functional and structural changes as well as their distributed localization across the whole brain, they overcome drawbacks of traditional univariate approaches. To evaluate the overall reliability of neuroimaging-based biomarkers, we conducted a comprehensive literature search to identify all studies that used multivariate pattern recognition to identify patterns of brain alterations that differentiate patients with schizophrenia from healthy controls. A bivariate random-effects meta-analytic model was implemented to investigate the sensitivity and specificity across studies as well as to assess the robustness to potentially confounding variables. In the total sample of n=38 studies (1602 patients and 1637 healthy controls), patients were differentiated from controls with a sensitivity of 80.3% (95% CI: 76.7-83.5%) and a specificity of 80.3% (95% CI: 76.9-83.3%). Analysis of neuroimaging modality indicated higher sensitivity (84.46%, 95% CI: 79.9-88.2%) and similar specificity (76.9%, 95% CI: 71.3-81.6%) of rsfMRI studies as compared with structural MRI studies (sensitivity: 76.4%, 95% CI: 71.9-80.4%, specificity of 79.0%, 95% CI: 74.6-82.8%). Moderator analysis identified significant effects of age (p=0.029), imaging modality (p=0.019), and disease stage (p=0.025) on sensitivity as well as of positive-to-negative symptom ratio (p=0.022) and antipsychotic medication (p=0.016) on specificity. Our results underline the utility of multivariate pattern recognition approaches for the identification of reliable neuroimaging-based biomarkers. Despite the clinical heterogeneity of the schizophrenia phenotype, brain functional and structural alterations differentiate schizophrenic patients from healthy controls with 80% sensitivity and specificity.
authors.affiliation: 1] Department of Psychiatry, Ludwig-Maximilians University Munich, Munich, Germany [2] King's College London, Psychosis Clinical Academic Group, Institute of Psychiatry, London, UK.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kambeitz
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Lana
authors.initials: L
authors.lastname: Kambeitz-Ilankovic
authors.affiliation: Department of Psychiatry, Technical University Munich, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Leucht
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Wood
authors.affiliation: Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Pennsylvania, USA.
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Berend
authors.initials: B
authors.lastname: Malchow
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Koutsouleris
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000473:pathology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D006801:Humans; D059906:Neuroimaging; D021641:Recognition, Psychology / Q000502:physiology*; D012559:Schizophrenia / Q000473:pathology*
chemical_list: D015415:Biomarkers