title: Diagnosis of functioning pancreaticoduodenal neuroendocrine tumors.
abstract: Functioning pancreaticoduodenal neuroendocrine tumors (PD-NETs) are popular in a textbook, but they are still unfamiliar to a general clinician, and delay of diagnosis or misdiagnosis has been reported even today. It is a consensus that sporadic functioning PD-NET is cured only by surgical resection. So, early detection and early resection is the gold standard for the treatment of functioning PD-NET. Functioning PD-NETs in patients with multiple endocrine neoplasia type 1 (MEN 1) are often multiple. You should check about MEN 1 whenever you encountered multiple PD-NET. They are diagnosed in younger age than sporadic cases. In most cases they are accompanied with numerous microscopic or macroscopic nonfunctioning P-NETs, which are potentially metastatic and the most common cause of death in MEN 1 patients.
authors.affiliation: Neuroendocrine Tumor Center, Kansai Electric Power Hospital, 2-1-7 Fukushima, Fukushima, Osaka, 553-0003, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Imamura
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakamoto
authors.affiliation: Department of Gastroenterology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Uose
authors.affiliation: Neuroendocrine Tumor Center, Kansai Electric Power Hospital, 2-1-7 Fukushima, Fukushima, Osaka, 553-0003, Japan.|Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Komoto
authors.affiliation: Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Awane
authors.affiliation: Department of Surgery, Kansai Electric Power Hospital, Fukushima, Osaka, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Taki
mesh_terms: D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D005935:Glucagonoma / Q000175:diagnosis; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology
keywords: Functioning duodenal neuroendocrine tumor; Functioning pancreaticoduodenal neuroendocrine tumor; Gastrinoma; Insulinoma