title: [Clinical analyses of septic arthritis in neonates].
abstract: OBJECTIVE
  To explore the clinical features, the diagnostic and therapeutic strategies and different inflammatory indices for neonatal septic arthritis.
  
  
  METHODS
  Clinical presentations, laboratory findings, treatment and prognosis of patients with neonatal septic arthritis hospitalized from October 2009 to December 2013 were analyzed retrospectively.
  
  
  RESULTS
  Among 19 cases with septic arthritis in neonates, the sites were hip (n = 8), knee (n = 7) and shoulder (n = 4). And 13 cases had fever. Joint swelling, tenderness, skin temperature and activity limitation were absent in 9 cases. At initial presentations, the positive rates of C-reactive protein (CPR) and procalcitonin (PCT) were 63.2% and 83.3% respectively. And the differences were statistically significant (P < 0.05). At Day 1 after admission, the positive rates of CRP, PCT and erythrocyte sedimentation rate (ESR) were 100%, 100% and 41.6% respectively. No difference existed in positive rate between CPR and PCT (P > 0.05). The positive rate of ESR was lower than CPR and PCT and the difference was statistically significant (P < 0.05). Radiographic examination showed swelling of joint capsule, joint space widening and swelling of joint soft tissue. All were cured and discharged through intravenous antibiotic therapy. 16 cases were followed-up, except for 1 patient with hip disease due to poor rational dislocation motion. And the others were normal.
  
  
  CONCLUSIONS
  Neonatal septic arthritis should receive priority attention. With early diagnosis and standard treatment, the prognosis is usually good.
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Huixin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Caiyun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Xuefang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Shao
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Li
authors.affiliation: Affiliated Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. Email: cxswyj@vip.sina.com.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001170:Arthritis, Infectious; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D042241:Early Diagnosis; D005334:Fever; D006801:Humans; D007231:Infant, Newborn; D007592:Joint Diseases; D007719:Knee Joint; D011379:Prognosis; D011498:Protein Precursors; D012189:Retrospective Studies
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide