title: Reduced central corneal thickness in patients with isotretinoin treatment.
abstract: BACKGROUND
  It is well known that oral isotretinoin treatment causes numerous ocular side-effects.
  
  
  OBJECTIVE
  To investigate the effect of systemic isotretinoin treatment on central corneal thickness (CCT) values due to meibomian gland disease (MGD).
  
  
  METHODS
  In this prospective study, 47 patients (27 men, 20 women) with nodulocystic acne vulgaris treated with oral isotretinoin (0.8 mg/kg daily) were included.
  
  
  METHODS
  All patients were analyzed with the Pentacam Scheimpflug topography at baseline, on the 3rd and 6th month of treatment. Main outcome measures were MGD scores and CCT.
  
  
  RESULTS
  The mean age of patients was 25.1 ± 4.4 years. The mean MGD scores were significantly higher at 3rd month (1.3 ± 0.9) and 6th month (1.5 ± 1.0) of treatment compared with baseline (1.1 ± 0.9) (p < 0.001). The mean CCT value at baseline was 540.5 ± 22.1 µm; 536.9 ± 20.5 µm at 3rd month and 531.4 ± 22.2 µm at 6th month. The differences between baseline and 6th month CCT measurements were statistically significant (p < 0.001). There was negative correlation between mean MGD scores and CCT values at the 6th month of treatment which was statistically significant (p = 0.038, r = -0.221).
  
  
  CONCLUSIONS
  Isotretinoin treatment causes higher MGD scores. A statistically significant decrease in CCT due to MGD was detected at 6th month of treatment.
authors.affiliation: a Department of Ophthalmology , Ataturk Training and Research Hospital , Ankara , Turkey .
authors.forename: Nilay
authors.initials: N
authors.lastname: Yuksel
authors.affiliation: b Department of Ophthalmology , Necip Fazil City Hospital , Kahramanmaras , Turkey .
authors.forename: Mediha Dilek
authors.initials: MD
authors.lastname: Ozer
authors.affiliation: c Department of Ophthalmology , Yildirim Beyazit University , Ankara , Turkey , and.
authors.forename: Emine
authors.initials: E
authors.lastname: Akcay
authors.affiliation: c Department of Ophthalmology , Yildirim Beyazit University , Ankara , Turkey , and.
authors.forename: Umut
authors.initials: U
authors.lastname: Ozen
authors.affiliation: d Department of Dermatology , Megapark Hospital , Kahramanmaras , Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Uzun
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008537:Meibomian Glands / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: Acne vulgaris; central corneal thickness; isotretinoin; meibomian gland dysfunction