title: Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision.
abstract: Asymmetric cell division (ACD) is a simple and evolutionary conserved process whereby a mother divides to generate two daughter cells with distinct developmental potentials. This process can generate cell fate diversity during development. Fate asymmetry may result from the unequal segregation of molecules and/or organelles between the two daughter cells. Here, I will review how fate asymmetry is regulated in the sensory bristle lineage in Drosophila and focus on the molecular mechanisms underlying ACD of the sensory organ precursor cells (SOPs). For further resources related to this article, please visit the WIREs website.
authors.affiliation: Institut Pasteur, Paris, France; CNRS URA2578, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila / Q000254:growth & development*; D029721:Drosophila Proteins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D007605:Juvenile Hormones / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D058953:Neural Stem Cells / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism; D012679:Sense Organs / Q000166:cytology / Q000254:growth & development*; D008941:Spindle Apparatus / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007605:Juvenile Hormones; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein; C060606:numb protein, Drosophila; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila