title: Safe administration of a gelatin-containing vaccine in an adult with galactose-α-1,3-galactose allergy.
abstract: Immunoglobulin (Ig) E antibodies to galactose-α-1,3-galactose (α-Gal) are associated with delayed anaphylaxis to mammalian food products and gelatin-based foods (Commins et al., J Allergy Clin Immunol 2009;123:426; Caponetto et al., J Allergy Clin Immunol Pract 2013;1:302). We describe a patient with α-Gal allergy who successfully tolerated the live zoster vaccine and we review anaphylactic reactions reported to this vaccine. Our patient, who tolerated a vaccine containing the highest gelatin content, is reassuring but continued safety assessment of gelatin-containing vaccines for this patient cohort is recommended as there are multiple factors for this patient cohort that influence the reaction risk.
authors.affiliation: Department of Medicine, Joint Base Elmendorf-Richardson, Anchorage, AK, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Pinson
authors.affiliation: Department of Medicine, Landstuhl Regional Medical Center, Landstuhl, Germany. Electronic address: kirkandmary@gmail.com.
authors.forename: Kirk H
authors.initials: KH
authors.lastname: Waibel
mesh_terms: D000485:Allergens / Q000276:immunology; D000707:Anaphylaxis / Q000276:immunology; D004187:Disaccharides / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology; D005780:Gelatin / Q000276:immunology / Q000627:therapeutic use*; D053061:Herpes Zoster Vaccine / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008460:Meat / Q000009:adverse effects; D008875:Middle Aged; D012882:Skin Tests; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000485:Allergens; D004187:Disaccharides; D053061:Herpes Zoster Vaccine; D014613:Vaccines, Attenuated; C055075:galactosyl-(1-3)galactose; D007073:Immunoglobulin E; D005780:Gelatin
keywords: Gelatin; Red meat allergy; Vaccine, α-Gal allergy