title: A single-blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts.
abstract: OBJECTIVE
  To evaluate the efficacy of sequential therapy of cryotherapy and sinecatechins 15% ointment BID versus cryotherapy alone in treatment of external genital warts (EGW).
  
  
  METHODS
  Forty-two subjects with at least two EGW lesions underwent cryotherapy to all lesions. One week following cryotherapy, subjects were randomized 1:1 to receive either no additional treatment or treatment with sinecatechins 15% ointment BID up to 16 weeks or until complete clearance. The total number of visible baseline and new EGW were recorded at each visit. Subjects were followed for a total of 65 weeks post-treatment.
  
  
  RESULTS
  There was a significant reduction in mean number of lesions from baseline after 16 weeks of treatment in the cryotherapy-sinecatechins ointment group compared to cryotherapy alone (-5.0 lesions vs -2.1 lesions respectively, P=0.07).
  
  
  CONCLUSIONS
  Cryotherapy plus sinecatechins 15% ointment BID resulted in a significant improvement in the reduction of EGW compared to cryotherapy alone. Clinicaltrials.gov registration identifier: NCT02147353.
authors.forename: Shelbi C Jim
authors.initials: SC
authors.lastname: On
authors.forename: Rita V
authors.initials: RV
authors.lastname: Linkner
authors.forename: Madelaine
authors.initials: M
authors.lastname: Haddican
authors.forename: Alex
authors.initials: A
authors.lastname: Yaroshinsky
authors.forename: Matthew
authors.initials: M
authors.lastname: Gagliotti
authors.forename: Giselle
authors.initials: G
authors.lastname: Singer
authors.forename: Gary
authors.initials: G
authors.lastname: Goldenberg
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000628:therapy*; D017679:Cryotherapy / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D002392:Catechin