title: Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in pregnancy.
abstract: BCR-ABL inhibitors administered in conjunction with chemotherapy have significantly improved outcomes in Philadelphia chromosome-positive acute lymphoblastic leukemia but, for patients diagnosed during pregnancy, data on risks to the fetus are limited. We report a woman treated with chemotherapy and imatinib mesylate who delivered a healthy baby at 30 weeks, and we discuss available data.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, USA cmainor@umm.edu.
authors.forename: Candace B
authors.initials: CB
authors.lastname: Mainor
authors.affiliation: Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, USA.
authors.forename: Alison P
authors.initials: AP
authors.lastname: Duffy
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, USA.
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Atkins
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, USA Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Kimball
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, USA Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA.
authors.forename: Maria R
authors.initials: MR
authors.lastname: Baer
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D007231:Infant, Newborn; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate
keywords: Acute lymphoblastic leukemia; imatinib mesylate; pregnancy