title: Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.
abstract: Stability of myogenic tone in middle cerebral arteries (MCA) is essential for adequate control over penetration of pressure waves into the distal portion of the cerebral microcirculation. Because the increased pulse pressure observed in advanced aging is associated with cerebromicrovascular injury, the effect of aging on myogenic response of mouse MCAs was determined. Aging did not affect the myogenic constriction in response to static increases in pressure, whereas it significantly impaired pulsatile pressure-induced myogenic tone. Impaired myogenic adaptation of MCAs to pulsatile pressure may allow high pressure to penetrate the distal portion of the cerebral microcirculation, contributing to microvascular damage.
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Springo
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Toth
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Stefano
authors.initials: S
authors.lastname: Tarantini
authors.affiliation: Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Ashpole
authors.affiliation: Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Tucsek
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [3] The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Sonntag
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary [3] Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [4] The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
authors.affiliation: 1] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary [2] Department of Physiology, New York Medical College, Valhalla, New York, USA.
authors.forename: Akos
authors.initials: A
authors.lastname: Koller
authors.affiliation: 1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary [3] Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [4] The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Zoltan I
authors.initials: ZI
authors.lastname: Ungvari
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020768:Middle Cerebral Artery / Q000502:physiology* / Q000503:physiopathology; D011673:Pulsatile Flow; D014661:Vasoconstriction