title: Cationic fluorescent polymer core-shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA.
abstract: A multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core-shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency over the most popular transfection reagent, Lipofectamine 2000. Fluorescence resonance energy transfer within the nanocarrier provides a non-invasive and label-free method to track the intracellular release of siRNA.
authors.affiliation: Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China. qdshen@nju.edu.cn.
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Yu
authors.forename: Sha
authors.initials: S
authors.lastname: Zhu
authors.forename: Pei-Jian
authors.initials: PJ
authors.lastname: Feng
authors.forename: Cheng-Gen
authors.initials: CG
authors.lastname: Qian
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Sun
authors.forename: Qun-Dong
authors.initials: QD
authors.lastname: Shen
mesh_terms: D002214:Capsules; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002214:Capsules; D004337:Drug Carriers; D005456:Fluorescent Dyes; D011108:Polymers; D034741:RNA, Small Interfering