title: Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population.
abstract: OBJECTIVE
  To clarify the association of rs11196218 polymorphism in transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Asian population by a case-control study and meta-analysis.
  
  
  METHODS
  In the case-control study, 1842 patients with T2DM and 7777 normal glucose-tolerant controls in the Henan province of China were genotyped for rs11196218 in TCF7L2 by PCR-ligase detection reaction. We used allele, co-dominant, dominant and recessive models to evaluate the risk association and performed a meta-analysis of the results of different genetic models in previous studies and the current study.
  
  
  RESULTS
  The AG genotype of rs11196218 was associated with risk of T2DM in the Henan population (odds ratio 1.37, 95% confidence interval 1.06-1.78), and dominant model showed marginal significant association (1.28, 0.99-1.67). Meta-analysis of 10 studies revealed the dominant model associated with T2DM in the overall population (1.20, 1.05-1.36). When stratified by region (southern and northern China and Japan), both the AG genotype and the dominant model were associated with risk of T2DM in southern Chinese (1.31, 1.03-1.66; 1.27, 1.01-1.60, respectively).
  
  
  CONCLUSIONS
  The rs11196218 polymorphism in TCF7L2 is associated with risk of T2DM in Asian population.
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of China.
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Haifei
authors.initials: H
authors.lastname: You
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pang
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Tan
authors.initials: T
authors.lastname: Guo
authors.affiliation: Military Hospital of Henan Province, Zhengzhou 450003, People's Republic of China.
authors.forename: Tianping
authors.initials: T
authors.lastname: Feng
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Chongjian
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Gao
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Luo
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Traditional Chinese Medicine Prevention, Preventive Medicine Research Evaluation Center, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hu
keywords: 95% CI, 95% confidence interval; MAF, minor allele frequency; OR, odds ratio; PARP, population-attributable risk proportion; PCR–LDR, polymerase chain reaction–ligase detection reaction; SNP, single nucleotide polymorphism; Single nucleotide polymorphism; T2DM, type 2 diabetes mellitus; TCF7L2; TCF7L2, factor 7-like 2 gene; Type 2 diabetes mellitus; rs11196218