title: [Multivariate analysis of risk factors for pulmonary infection after radical gastrectomy for gastric cancer].
abstract: OBJECTIVE
  To explore the major risk factors for pulmonary infection after radical gastrectomy in patients with gastric cancer.
  
  
  METHODS
  From November 2010 to February 2014, a total of 765 patients undergoing radical gastrectomy at our hospital were divided into 2 groups based upon the presence of postoperative pulmonary infection (n = 32, 4.2%) or not (n = 733, 95.8%). Their clinicopathological data were retrospectively analyzed by Logistic regressive analysis with a case-control study model.
  
  
  RESULTS
  Comparing with the control group, the patients had longer surgical duration (245.7 ± 66.7 vs 210.9 ± 47.2 min, P < 0.01), higher rates of requiring intensive care (12.50% vs 2.86%, P = 0.02) and longer post-operative hospital stays (21.9 ± 24.9 vs 14.2 ± 4.2 days, P < 0.01) in the postoperative pulmonary infection group.Univariate Logistic regressive analysis found that age ≥ 60 years, smoking ≥ 400 year by cigarette, diabetes mellitus, chronic obstructive pulmonary disease, proximal or total gastrectomy, combined organ resection, surgical duration ≥ 240 min, intra-operative blood loss ≥ 300 ml, peri-operative transfusion, transfusion ≥ 3 unit packed red blood cell, post-operative transfusion and post-operative complications other than pulmonary infections were associated with postoperative pulmonary infection (all P < 0.05).Further multivariate analysis identified 4 independent risk factors for pulmonary infection after radical gastrectomy, including diabetes mellitus (OR = 4.77, 95%CI:1.18-19.23), post-operative complications other than pulmonary infections (OR = 3.15, 95%CI:1.25-7.90), intra-operative blood loss ≥ 300 ml (OR = 2.63, 95%CI:1.17-5.90) and post-operative nasogastric tube ≥ 5 days (OR = 2.30, 95%CI:1.02-5.21).
  
  
  CONCLUSIONS
  Correcting the modifiable risk factors may reduce the incidence of pulmonary infection and shorten the length of hospital stays and costs after radical gastrectomy in patients with gastric cancer.
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China. Email: zuochaohui@vip.sina.com.
authors.forename: Chaohui
authors.initials: C
authors.lastname: Zuo
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Ouyang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yin
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Quan
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Cancer Hospital, Xiangya School of Medicine, Central South University, Changsha 410013, China.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Qiu
mesh_terms: D001803:Blood Transfusion; D016022:Case-Control Studies; D003141:Communicable Diseases; D005743:Gastrectomy; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D017713:Platelet Transfusion; D011014:Pneumonia; D011183:Postoperative Complications; D029424:Pulmonary Disease, Chronic Obstructive; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms