title: Insights into a microwave susceptible agent for minimally invasive microwave tumor thermal therapy.
abstract: This work develops a kind of sodium alginate (SA) microcapsules as microwave susceptible agents for in vivo tumor microwave thermal therapy for the first time. Due to the excellent microwave susceptible properties and low bio-toxicity, excellent therapy efficiency can be achieved with the tumor inhibiting ratio of 97.85% after one-time microwave thermal therapy with ultralow power (1.8 W, 450 MHz). Meanwhile, the mechanism of high microwave heating efficiency was confirmed via computer-simulated model in theory, demonstrating that the spatial confinement efficiency of microcapsule walls endows the inside ions with high microwave susceptible properties. This strategy offers tremendous potential applications in clinical tumor treatment with the benefits of safety, reliability, effectiveness and minimally invasiveness.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
authors.forename: Haitang
authors.initials: H
authors.lastname: Shi
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Electronic Engineering, Huaihai Institute of Technology, Lianyungang 222005, People's Republic of China.
authors.forename: Jingzhuo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Beijing M&Y Electronics Co. Ltd., Beijing 100015, People's Republic of China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China. Electronic address: mengxw@mail.ipc.ac.cn.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D002214:Capsules; D016923:Cell Death; D002470:Cell Survival; D003198:Computer Simulation; D005260:Female; D006361:Heating; D006461:Hemolysis; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007279:Injections, Subcutaneous; D008813:Mice, Inbred ICR; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D009369:Neoplasms / Q000628:therapy*; D010316:Particle Size; D011817:Rabbits; D013818:Thermogravimetry; D018675:Toxicity Tests
chemical_list: D002214:Capsules
keywords: Microcapsule; Microwave; Sodium alginate; Thermal therapy; Tumor