title: Palladium-catalyzed intramolecular C(sp(2))-H imidoylation for the synthesis of six-membered N-heterocycles.
abstract: A new strategy for the construction of phenanthridine and isoquinoline scaffolds, starting from arenes containing a pending isocyanide moiety under palladium catalysis, has been developed. This process involves sequential intermolecular isocyanide insertion to an aryl palladium(II) intermediate and intramolecular aromatic C-H activation as key steps. Alkyl palladium(II) intermediate lacking β-hydrogen is also applicable to this reaction, generating unique bisheterocyclic scaffolds with three C-C bonds being formed consecutively.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue, Guangzhou 510530, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yimiao
authors.initials: Y
authors.lastname: He
authors.forename: Shuang
authors.initials: S
authors.lastname: Luo
authors.forename: Jian
authors.initials: J
authors.lastname: Lei
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Zeqiang
authors.initials: Z
authors.lastname: Xie
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007094:Imides / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007094:Imides; D009942:Organometallic Compounds; D010165:Palladium