title: Asymmetric conjugate additions and allylic alkylations using nucleophiles generated by hydro- or carbometallation.
abstract: This Minireview discusses catalytic asymmetric conjugate addition and allylic alkylation reactions where the nucleophiles were generated in situ by hydrometallation or carbometallation. This exciting recent trend in asymmetric catalysis promises to expand the range of transformations available for the rapid and selective assembly of complex, functional molecules for both academic and industrial research. This Minireview aims to serve as a reference for studies reported to date and discusses the current state-of-the-art, scope and limitations of these processes.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Rd., Oxford, OX1 3TA (UK).
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Maksymowicz
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Bissette
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Fletcher
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D008670:Metals / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D008670:Metals
keywords: Michael addition; asymmetric catalysis; conjugate addition; metallation reactions; synthetic methods