title: Post-transcriptional regulation of long noncoding RNAs in cancer.
abstract: It is a great surprise that the genomes of mammals and other eukaryotes harbor many thousands of long noncoding RNAs (lncRNAs). Although these long noncoding transcripts were once considered to be simply transcriptional noise or cloning artifacts, multiple studies have suggested that lncRNAs are emerging as new players in diverse human diseases, especially in cancer, and that the molecular mechanisms of lncRNAs need to be elucidated. More recently, evidence has begun to accumulate describing the complex post-transcriptional regulation in which lncRNAs are involved. It was reported that lncRNAs can be implicated in degradation, translation, pre-messenger RNA (mRNA) splicing, and protein activities and even as microRNAs (miRNAs) sponges in both a sequence-dependent and sequence-independent manner. In this review, we present an updated vision of lncRNAs and summarize the mechanism of post-transcriptional regulation by lncRNAs, providing new insight into the functional cellular roles that they may play in human diseases, with a particular focus on cancers.
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China, shixuefei1223@aliyun.com.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Yao
authors.forename: Hongbing
authors.initials: H
authors.lastname: Liu
authors.forename: Guannan
authors.initials: G
authors.lastname: Wu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yuan
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding