title: [High doses of aldosterone antagonist is a condition of sufficient blood pressure control in bilateral adrenal hyperplasia].
abstract: Primary aldosteronism occurs in 1-10% of hypertensive patients and is classified in adenomas or bilateral adrenal hyperplasia. Computed tomography (CT) or magnetic resonance imaging can be used to discriminate these subtypes and in guiding treatment selection. This case report describes a 65-year-old man with hypertension and hypokalaemia during 25 years. Bilateral adrenal hyperplasia was diagnosed based on a CT, and an oral sodium-loading test with measurement of renin and aldosterone confirmed the diagnosis. Blood pressure and potassium in plasma was normalized during treatment with the mineralocorticoid receptor antagonist eplerenon.
authors.affiliation: Regionshospitalet Holstebro, Lægårdvej 12, 7500 Holstebro. safatherwani@hotmail.com.
authors.forename: Safa
authors.initials: S
authors.lastname: Therwani
authors.forename: Erling Bjerregaard
authors.initials: EB
authors.lastname: Pedersen
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D000077545:Eplerenone; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D013148:Spironolactone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D000077545:Eplerenone