title: [Effects of wine polyphenols on cancer prevention].
abstract: BACKGROUND
  Cancer has become in the recent decades one of the leading causes of death worldwide. The search for effective prevention has become a priority for the basic and clinical science. Wine polyphenols have been proposed as alternative therapy for induction and on maintaining remission of cancer.
  
  
  OBJECTIVE
  To review current scientific evidence of cancer and the efficacy of dietary supplement therapy (especially wine polyphenols).
  
  
  METHODS
  Extensive search of scientific publications was performed in specialized electronic databases: NBCI, Elsevier, Scielo, Scirus and Science Direct.
  
  
  CONCLUSIONS
  Results from in vitro and laboratory animals experiments demonstrate that wine polyphenols controls the cell apoptosis of different type of cancers through out the increase of reactive oxygen species, and decrease of cell growth. Different studies have shown that regular and moderate wine consumption (one or two glasses for day) is associated with decreased incidence of cardiovascular disease, hypertension, diabetes, and certain cancers, such as colon, breast, lung, or prostate. However, more scientific evidences are needed to strength the effect of resveratrol in controlling cancer.
  
  
  CONCLUSIONS
  A better knowledge and understanding of the wine polyphenol role in cancer disease patients is possible with the current published results. The wine polyphenols plays a significant role as antioxidant and prooxidant in cancer, although more extensive studies are required to determine the clinical significance in humans.
authors.affiliation: Àrea de Ciències de la Salut, Institut Internacional de Postgrau de la Universitat Oberta de Catalunya (UOC), 08035, Barcelona, España.. nuria.mach@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Sancho
authors.affiliation: Àrea de Ciències de la Salut, Institut Internacional de Postgrau de la Universitat Oberta de Catalunya (UOC), 08035, Barcelona, España. INRA, Animal Genetics and Integrative Biology lab - GABI department, Jouy-en-Josas, Francia.. nuria.mach@gmail.com.
authors.forename: Núria
authors.initials: N
authors.lastname: Mach
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D059808:Polyphenols / Q000627:therapeutic use*; D014920:Wine / Q000032:analysis*
chemical_list: D059808:Polyphenols