title: Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats.
abstract: Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids and stress biochemical parameters of rats. Male albino Wistar rats were randomly divided into 6 groups of 5 animals each and treated orally with Cd (50 mg/l), olive oil and colocynth oil (4%) alone or in combination with cadmium for 8 weeks. It was shown that Cd exposure induced significant increases in the activities of serum alanine aminotransferase, aspartate aminotransferase, lipid peroxidation levels (MDA) and protein carbonyl contents in exposed groups of rats compared to control group while the antioxidant enzymes, reduced glutathione and vitamins (C, A and E) were significantly decreased. Co-treatment with olive oil or colocynth oil significantly improved the oxidative damage induced by Cd. The antioxidant potential in plasma and liver were markedly restored with a significant decline in MDA levels and activity of transaminases. In conclusion, these results suggest that olive oil or colocynth oil consumption could protect the rat liver against Cd-induced injury by increasing the activities of antioxidant enzymes and reducing oxidative stress.
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Amamou
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria; Department of biology, Faculty of SNV, University of Mostaganem, Mostaganem 27000, Algeria. Electronic address: snemiche@hotmail.com.
authors.forename: Saïd
authors.initials: S
authors.lastname: Nemmiche
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
authors.forename: Radjaa Kaouthar
authors.initials: RK
authors.lastname: Meziane
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
authors.forename: Amal
authors.initials: A
authors.lastname: Didi
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
authors.forename: Sidi Mohamed
authors.initials: SM
authors.lastname: Yazit
authors.affiliation: Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
authors.forename: Daoudi
authors.initials: D
authors.lastname: Chabane-Sari
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002104:Cadmium / Q000633:toxicity*; D002374:Catalase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D065986:Citrullus colocynthis / Q000737:chemistry*; D005227:Fatty Acids / Q000097:blood; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D000069463:Olive Oil / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000008:administration & dosage*; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D005227:Fatty Acids; D000069463:Olive Oil; D010938:Plant Oils; D002104:Cadmium; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D001205:Ascorbic Acid
keywords: Cadmium; Colocynth oil; Liver; Olive oil; Oxidative stress; Rats