title: A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation.
abstract: Cytokines have always been of great interest due to their vast potential and participation in the progression and pathogenesis of various ailments. Interleukin-32 (IL-32) is a recently identified cytokine, whose gene is located on human chromosome 16 p13.3, with eight exons and six splice variants (IL-32α to IL-32ζ). IL-32α, the most abundant form, is secreted by different types of cells including T cells, natural killer (NK) cells, monocytes, endothelial cells and epithelial cells. It acts as a preferential mediator and effector of abnormal immune responses to multiple inflammatory and auto immune diseases including rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD), etc. It was found to stimulate the induction of various chemokines, pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α and macrophage inflammatory protein-2 (MIP-2). Hence, IL-32 mediates the crucial interplay among immune system and body cells during pathogenesis of various insults. The aim of the present effort is to summarize the role, mechanism of pathogenesis and potential therapeutic applications of IL-32 in different systemic infections and diseased conditions.
authors.affiliation: Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan. babarkhawar@yahoo.com.
authors.forename: Babar
authors.initials: B
authors.lastname: Khawar
authors.affiliation: Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan. muddygcs@gmail.com.|Department of Zoology, Governments. College of Science, Wahdat Road, Lahore, Pakistan. muddygcs@gmail.com.
authors.forename: Muddasir Hassan
authors.initials: MH
authors.lastname: Abbasi
authors.affiliation: Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan. s_nadeem77@yahoo.com.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Sheikh
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000276:immunology*; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000276:immunology*
chemical_list: C496971:IL32 protein, human; D007378:Interleukins