title: Deubiquitinases and the new therapeutic opportunities offered to cancer.
abstract: Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure-function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to regulatory mechanisms and their growing protein interaction networks. We then describe DUBs that have been associated with endocrine carcinogenesis with a focus on prostate, ovarian, and thyroid cancer, pheochromocytoma, and adrenocortical carcinoma. The goal is enhancing our understanding of the connection between dysregulated DUBs and cancer to permit the design of therapeutics and to establish biomarkers that could be used in diagnosis and prognosis.
authors.affiliation: Department of BiologyYork University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3.
authors.forename: Roland
authors.initials: R
authors.lastname: Pfoh
authors.affiliation: Department of BiologyYork University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3.
authors.forename: Ira Kay
authors.initials: IK
authors.lastname: Lacdao
authors.affiliation: Department of BiologyYork University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3 vsaridak@yorku.ca.
authors.forename: Vivian
authors.initials: V
authors.lastname: Saridakis
mesh_terms: D000818:Animals; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000037:antagonists & inhibitors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism; D064570:Ubiquitin-Specific Proteases / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases
keywords: A20; BAP1; CYLD; UCHL1; USP22; USP7; ataxin 3; deubiquitinases