title: The relation of preeclampsia and serum level of 25-hydroxyvitamin D in mothers and their neonates: a case control study in Iran.
abstract: The predisposing factors of preeclampsia may endanger the mother's heath as well as her neonate. One hypothesis related to preeclampsia is vitamin D deficiency or insufficiency. This study was conducted to evaluate the relationship between preeclampsia and the serum level of 25-hydroxyvitamin D (25-OH-D) in mothers and their neonates. In this case-control study, we recruited 41 preeclamptic and 50 healthy women from the Imam Khomeini Hospital in Ahvaz, Iran. Venous blood (2 ml) from mothers (in time of labor) and 2 ml of blood from the umbilical cord were taken, centrifuged, stored at -30°C and sent to a laboratory for analysis of 25-OH-D by ELISA. Vitamin D levels<20 ng/ml were regarded as deficiency, levels between 21-29 ng/ml were regarded as insufficiency, and if levels were higher than 30 ng/ml, these were considered normal. Independent t-test, chi-square, Spearman correlation coefficient and logistic regression were used to analyze data. Mean levels of 25-OH-D were significantly lower in preeclamptic women (15.2±13.6 vs. 23.3±15.3 ng/ml, p=0.001) and in their neonates (15.2±13.1 vs. 21.6±12.6 ng/ml, p=0.01) compared to normal pregnant women and their neonates. There was a significant relationship between the levels of vitamin D in preeclamptic women with levels of this vitamin in their neonates (r=0.901, p=0.0001). 25-OH-D deficiency that exist in preeclamptic mothers, may be a health risk for their infants, therefore, early use of vitamin D supplement with higher dose than 400 IU in Iranian women is recommended.
authors.affiliation: Family Health, Health Deputy of Medical University of Yasuj, Yasuj, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Mohaghegh
authors.affiliation: Midwifery Department, Reproductive Health Promotion Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Abedi
authors.affiliation: Midwifery Department, The International University of Shahid Beheshti Medical University, Tehran, Iran.
authors.forename: T
authors.initials: T
authors.lastname: Dilgouni
authors.affiliation: Institute of Tropical Forestry and Forest Products (INTROP), University Putra Malaysia, UPM Serdang, Selangor, Malaysia.
authors.forename: F
authors.initials: F
authors.lastname: Namvar
authors.affiliation: Midwifery Department, Yasuj Medical University of Medical Sciences, Yasuj, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Ruzafza
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019587:Dietary Supplements; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D