title: Coronary vasospasm secondary to 5-Fluorouracil and its management: case report.
abstract: Although rare, 5-fluorouracil (5-FU) may lead to cardiotoxicity that presents with angina, elevated cardiac enzymes and electrocardiogram (ECG) changes. Coronary vasospasm related to 5-FU is a rare clinical entity in oncological practice and may be seen during both bolus and protracted infusional administration. This toxicity is generally reversible and responds well to conventional anti-angina treatment following discontinuation of infusion. We propose that parenteral diltiazem is an effective and safe approach for the treatment of coronary vasospasm secondary to 5-FU infusion. We present clinical findings and management of a case in which coronary vasospasm occurred during the infusion of the 5-FU component of FOLFIRI-bevacizumab chemotherapy (CT) regimen given for treatment of metastatic rectal cancer.
authors.affiliation: Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
authors.affiliation: Department of Radiation Oncology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Parlak
authors.affiliation: Department of Pathology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Sezer
authors.affiliation: Department of Surgery, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Eryilmaz
authors.affiliation: Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Kaya
authors.affiliation: Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildiz
keywords: 5-fluorouracil; Coronary vasospasm; Diltiazem