title: Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation.
abstract: The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding properties and efficient inhibition of protein assemblies.
authors.affiliation: Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. p.y.w.dankers@tue.nl.
authors.forename: Mellany
authors.initials: M
authors.lastname: Ramaekers
authors.forename: Sjors P W
authors.initials: SP
authors.lastname: Wijnands
authors.forename: Joost L J
authors.initials: JL
authors.lastname: van Dongen
authors.forename: Luc
authors.initials: L
authors.lastname: Brunsveld
authors.forename: Patricia Y W
authors.initials: PY
authors.lastname: Dankers
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008164:Luminescent Proteins / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D055503:Protein Multimerization; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001426:Bacterial Proteins; D001952:Bridged-Ring Compounds; D007093:Imidazoles; D008164:Luminescent Proteins; D009842:Oligopeptides; D011092:Polyethylene Glycols; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils; C054562:yellow fluorescent protein, Bacteria; C043963:phenylalanyl-glycyl-glycine