title: Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.
abstract: The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1β , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
authors.affiliation: Department of Periodontology, College of Dentistry, Wonkwang University, Iksan 570-749, Korea.
authors.forename: Wan-Su
authors.initials: WS
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Choi
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Sunwoo
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Woo Joong
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea. ; DOSIS M&M, Seoul 143-891, Korea.
authors.forename: Dong Chae
authors.initials: DC
authors.lastname: Lee
authors.affiliation: Asia Pacific International School, Seoul 139-852, Korea.
authors.forename: Uy Dong
authors.initials: UD
authors.lastname: Sohn
authors.affiliation: Department of Periodontology, College of Dentistry, Wonkwang University, Iksan 570-749, Korea.
authors.forename: Hyoung-Shik
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Wonyong
authors.initials: W
authors.lastname: Kim
keywords: Anti-inflammatory effect; Anti-microbial activity; Antioxidant activity; Artemisinin