title: Lubiprostone decreases the small bowel transit time by capsule endoscopy: an exploratory, randomised, double-blind, placebo-controlled 3-way crossover study.
abstract: The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117-407) minutes in the P-P regimen, 122.5 (27-282) minutes in the L-P regimen, and 110.5 (11-331) minutes in the P-L regimen (P = 0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE.
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Mizue
authors.initials: M
authors.lastname: Matsuura
authors.affiliation: Office of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsuura
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanoshima
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Inoh
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujita
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Umezawa
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Fuyuki
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Uchiyama
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Higurashi
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ohkubo
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.affiliation: Division of Gastroenterology, Nippon Medical School, Tokyo 113-8603, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Futagami
authors.affiliation: Department of General Medicine, Yokohama City University School of Medicine, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kusakabe
authors.affiliation: Department of Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.affiliation: Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima