title: SiRNA nanotherapeutics _the panacea of diseases?
abstract: RNAi based therapeutics hold s great promises to be an efficient strategy of the anti-gene realm in context of its therapeutic applications; however, despite significant potentials, its full efficacy cannot be realized in real sense owing to various confronts that plague its advancement. Efforts need to be driven for the development of specific and efficacious strategies to subdue some of their crucial constraints towards successes in clinics. This article will present the major impediments that encumber successful translation of siRNA concept into reality and the ongoing research endeavours to get through those stumbling blocks along with their inadequacies.
authors.forename: Khan Farheen
authors.initials: KF
authors.lastname: Badrealam
authors.forename: Swaleha
authors.initials: S
authors.lastname: Zubair
authors.affiliation: Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, AMU, Aligarh, India: 202002. owais_lakhnawi@yahoo.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Owais
mesh_terms: D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering