title: [Papillary edema in Muckle-Wells syndrome].
abstract: Papillary edema may occur isolated without functional impairment or secondary related to various syndromes, increased intracerebral pressure or associated with medicinal treatment. The Muckle-Wells syndrome is a rare disease, which among many other symptoms can lead to optic disc swelling and recurrent increase in intracerebral pressure. Besides familial cold-induced autoinflammatory syndrome (FCAS) and neonatal onset multisystem inflammatory disease (NOMID), the Muckle-Wells syndrome also belongs to the cryopyrin-associated periodic syndromes (CAPS). In most cases of CAP syndromes there is an underlying genetic disorder that leads to overproduction of interleukin-1β (IL-1β); therefore, typical symptoms include inflammation reactions, such as repeated skin rash, fatigue, fever, joint pain and conjunctivitis.
authors.affiliation: Universitätsaugenklinik Münster, Domagkstr. 15, 48149, Münster, Deutschland. Gabriele.wirths@ukmuenster.de.
authors.forename: G
authors.initials: G
authors.lastname: Wirths
authors.affiliation: Universitätsaugenklinik Münster, Domagkstr. 15, 48149, Münster, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Grenzebach
authors.affiliation: Universitätsaugenklinik Münster, Domagkstr. 15, 48149, Münster, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Eter
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D056587:Cryopyrin-Associated Periodic Syndromes / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010211:Papilledema / Q000175:diagnosis* / Q000188:drug therapy*; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Cryopyrin-associated periodic syndromes; Genetic disorder; Inflammatory reaction; Intracerebral pressure; Papillary edema