title: Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines.
abstract: A copper-catalyzed regio- and intermolecular aminofluorination of styrenes has been developed. In this reaction Ph-I=N-Ts and Et3N·3HF act as nitrogen and fluorine sources, respectively. The obtained β-fluoro-N-Ts-phenethylamines can be N-alkylated with subsequent deprotection affording the corresponding β-fluoro-N-alkylated phenethylamines, which are interesting building blocks for compounds acting on neuronal targets.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Casilla 306, Correo 22, Santiago, Chile. eperezh@uc.cl.
authors.forename: Jorge
authors.initials: J
authors.lastname: Saavedra-Olavarría
authors.forename: Gean C
authors.initials: GC
authors.lastname: Arteaga
authors.forename: Jhon J
authors.initials: JJ
authors.lastname: López
authors.forename: Edwin G
authors.initials: EG
authors.lastname: Pérez
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D010627:Phenethylamines / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
chemical_list: D010627:Phenethylamines; D013343:Styrenes; D005461:Fluorine; C029261:phenethylamine; D003300:Copper