title: Predictive value of phosphorylated insulin-like growth factor binding protein-1 (PIGFBP-1) (bedside test) in preterm labor.
abstract: This study evaluated the predictive value of phosphorylated insulin like growth factor binding protein-1 in cervical secretion as bedside test for prediction of preterm labor in symptomatic women. A total of 57 patients with singleton pregnancy at 24-34 weeks gestation, with symptoms suggestive of preterm labor were included in this study. A rapid cervical sample for PIGFBP-1 determination (Actim partus test, Medix Biochemical, and Kaunianen, Finland) was taken by means of a polyester-tipped swab during a speculum examination of the cervix, and extracted with specimen- extraction solution. We analyzed the prevalence of preterm labor in these patients within seven days upon admission. And calculate sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for PIGFBP-1. This study was done at Kuwait Oil Company hospital (KOC) and Taiba hospital (Kuwait) during the period between April 2011 and June 2012. The test was positive in 50.9% of patients and negative in 49.1%, among those tests was positive 64% delivered less than a week, and among those tests was negative 35.7 delivered less than one week, with 74.3% sensitivity, 61% spesivity, 76.3% PPV and 73.6% NPV.
authors.affiliation: Department of Obstetrics and Gynecology, Al-Azhar University, Nasr City, Egypt. amroaboelezz@gmail.com
authors.forename: Amro Elsayed
authors.initials: AE
authors.lastname: Abo El-Ezz
authors.forename: Alsaeed Elsayed A
authors.initials: AE
authors.lastname: Askar
mesh_terms: D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007124:Immunoenzyme Techniques; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009093:Mucus / Q000737:chemistry; D011237:Predictive Value of Tests; D011247:Pregnancy; D047928:Premature Birth / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
chemical_list: C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D011933:Reagent Kits, Diagnostic