title: Insights into the genetic foundations of human communication.
abstract: The human capacity to acquire sophisticated language is unmatched in the animal kingdom. Despite the discontinuity in communicative abilities between humans and other primates, language is built on ancient genetic foundations, which are being illuminated by comparative genomics. The genetic architecture of the language faculty is also being uncovered by research into neurodevelopmental disorders that disrupt the normally effortless process of language acquisition. In this article, we discuss the strategies that researchers are using to reveal genetic factors contributing to communicative abilities, and review progress in identifying the relevant genes and genetic variants. The first gene directly implicated in a speech and language disorder was FOXP2. Using this gene as a case study, we illustrate how evidence from genetics, molecular cell biology, animal models and human neuroimaging has converged to build a picture of the role of FOXP2 in neurodevelopment, providing a framework for future endeavors to bridge the gaps between genes, brains and behavior.
authors.affiliation: Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, 6525XD, The Netherlands.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Graham
authors.forename: Pelagia
authors.initials: P
authors.lastname: Deriziotis
authors.forename: Simon E
authors.initials: SE
authors.lastname: Fisher
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D003142:Communication; D014644:Genetic Variation; D006801:Humans; D007804:Language Development; D007806:Language Disorders / Q000235:genetics