title: In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers.
abstract: In this report, the oligosaccharides of hyaluronan (oHA)-histidine-menthone 1,2-glycerol ketal (MGK) (oHM) carried pH-sensitive MGK as hydrophobic moieties and oHA as the target of the CD44 receptor. The oHM could self-assemble, with a diameter of 65 nm. The cellular uptake, indicated by the fluorescent signals, was higher at 4 h. The ex vivo imaging indicated that micelles have a longer blood circulation, beyond 5 h. The fluorescence intensity of the micelles in the liver and spleen was much higher from 5 to 24 h. The CD44 receptor-targeting, indicated by the fluorescence signals of A549 and MDA-MB-231 group, were higher than those of the HepG2 and the control.
authors.affiliation: a Department of Pharmaceutics , School of Pharmacy, Yantai University , P. R. China.
authors.forename: Daquan
authors.initials: D
authors.lastname: Chen
authors.affiliation: a Department of Pharmaceutics , School of Pharmacy, Yantai University , P. R. China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Sun
authors.affiliation: a Department of Pharmaceutics , School of Pharmacy, Yantai University , P. R. China.|b State Key Laboratory of Long-acting and Targeting Drug Delivery System , Yantai , P. R. China.
authors.forename: Kaoxiang
authors.initials: K
authors.lastname: Sun
authors.affiliation: a Department of Pharmaceutics , School of Pharmacy, Yantai University , P. R. China.|b State Key Laboratory of Long-acting and Targeting Drug Delivery System , Yantai , P. R. China.
authors.forename: Wanhui
authors.initials: W
authors.lastname: Liu
authors.affiliation: a Department of Pharmaceutics , School of Pharmacy, Yantai University , P. R. China.|b State Key Laboratory of Long-acting and Targeting Drug Delivery System , Yantai , P. R. China.
authors.forename: Zimei
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D023041:Xenograft Model Antitumor Assays
chemical_list: C497483:CD44 protein, human; D004337:Drug Carriers; D018960:Hyaluronan Receptors; D008823:Micelles; D006820:Hyaluronic Acid
keywords: CD44 receptor-targeting; cellular uptake; oHA-histidine-menthone 1,2-glycerol ketal; oligosaccharides of hyaluronan