title: Potential Occupational Risks Associated with Pulmonary Toxicity of Carbon Nanotubes.
abstract: Given their remarkable properties, carbon nanotubes (CNTs) have made their way through various industrial and medicinal applications and the overall production of CNTs is expected to grow rapidly in the next few years, thus requiring an additional recruitment of workers. However, their unique applications and desirable properties are fraught with concerns regarding occupational exposure. The concern about worker exposure to CNTs arises from the results of recent animal studies. Short-term and sub-chronic exposure studies in rodents have shown consistent adverse health effects such as pulmonary inflammation, granulomas, fibrosis, genotoxicity and mesothelioma after inhalation or instillation of several types of CNTs. Furthermore, physicochemical properties of CNTs such as dispersion, functionalization and particle size can significantly affect their pulmonary toxicity. Risk estimates from animal studies necessitate implementation of protective measures to limit worker exposure to CNTs. Information on workplace exposure is very limited, however, studies have reported that CNTs can be aerosolized and attain respirable airborne levels during synthesis and processing activities in the workplace. Quantitative risk assessments from sub-chronic animal studies recommend the health-based need to reduce exposures below the recommended exposure limit of 1 µg/m3. Practice of prevention measures including the use of engineering controls, personal protective equipment, health surveillance program, safe handling and use, as well as worker training can significantly minimize worker exposure and improve worker health and safety.
authors.affiliation: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, USA.
authors.forename: Amruta
authors.initials: A
authors.lastname: Manke
authors.affiliation: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, USA ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
authors.forename: Sudjit
authors.initials: S
authors.lastname: Luanpitpong
authors.affiliation: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, USA ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
authors.forename: Yon
authors.initials: Y
authors.lastname: Rojanasakul
keywords: Carbon nanotube; Fibrosis; Occupational hazard; Pulmonary toxicity; Worker exposure