title: Acetylsalicylic acid resistance after renal transplantation.
abstract: BACKGROUND
  Cardiovascular diseases are a leading cause of mortality after kidney transplantation. According to guidelines, acetylsalicylic acid (ASA) must be given as preventive antiplatelet therapy, but resistance to this drug is also well-known.
  
  
  METHODS
  A total of 214 renal transplant patients were included in our study and took 100 mg of ASA q.d. Aggregometry was performed to determine resistance. Twenty-four variables were examined using logistic regression analysis as possible causes of resistance.
  
  
  RESULTS
  ASA resistance was observed in 40.18% of the patients. Resistance reduced concomitant statin therapy and significantly increased simultaneous cyclosporine therapy.
  
  
  CONCLUSIONS
  Our study assessed the post-transplant ASA resistance in a large population. Clarification of this matter is crutial, since one of the major preventive pharmacological therapies of cardiovascular mortality is not effective in a significant number of patients.
authors.affiliation: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Adam
authors.initials: A
authors.lastname: Varga
authors.affiliation: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sandor
authors.affiliation: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Karoly Kalmar
authors.initials: KK
authors.lastname: Nagy
authors.affiliation: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Maria
authors.initials: M
authors.lastname: Viola
authors.affiliation: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Toth
authors.affiliation: Department of Public Health Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Gombos
authors.affiliation: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors.forename: Kalman
authors.initials: K
authors.lastname: Toth
authors.affiliation: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary drszakalyp@t-online.hu.
authors.forename: Peter
authors.initials: P
authors.lastname: Szakaly
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D016572:Cyclosporine; D001241:Aspirin
keywords: Aggregometry; acetylsalicylic acid resistance; cardiovascular complication; platelet aggregation; transplantation