title: Comparison of venous and HePTFE tibial and peroneal bypasses in critical limb ischemia patients unsuitable for endovascular revascularization.
abstract: BACKGROUND
  We examined short- and long-term outcomes of tibial and peroneal venous and heparin-bonded expanded polytetrafluoroethylene bypasses in patients with critical limb ischemia who were unsuitable for endovascular revascularization.
  
  
  METHODS
  A retrospective analysis was done for all patients who underwent tibial and peroneal bypass surgery in our department between October 2007 and October 2012. Vein was the preferred graft material and used whenever possible.
  
  
  RESULTS
  One hundred and ninety-eight crural grafts were included. Indications for the surgery were rest pain (30.3%) or ulcer or gangrene (69.7%). Autologous veins were used in 109 cases (vein group) and heparin-bonded expanded polytetrafluoroethylene grafts were used in 89 cases (heparin-bonded expanded polytetrafluoroethylene group). At three years, primary patency for the vein group was 68.2% versus 34.1% for the heparin-bonded expanded polytetrafluoroethylene group (P = .000) and secondary patency was 69.8% versus 35.5% (P = .001). Limb salvage was 81.8% for the vein group versus 56.5% for the heparin-bonded expanded polytetrafluoroethylene group (P = .000) and survival was 62.8% versus 46.7% (P = .019).
  
  
  CONCLUSIONS
  The results of our study show that autologous vein grafts are still first choice for tibial and peroneal bypasses in patients with critical limb ischemia. If no adequate vein is available, heparin-bonded expanded polytetrafluoroethylene bypasses are an acceptable alternative to an otherwise impending major amputation.
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany christian.uhl@barmherzige-regensburg.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Uhl
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Hock
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Betz
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Greindl
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.
authors.forename: Ingolf
authors.initials: I
authors.lastname: Töpel
authors.affiliation: Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Steinbauer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D020099:Coated Materials, Biocompatible; D016638:Critical Illness; D016208:Databases, Factual; D005260:Female; D005858:Germany; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000601:surgery; D016016:Proportional Hazards Models; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014654:Vascular Patency; D014680:Veins / Q000503:physiopathology / Q000637:transplantation*
chemical_list: D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D011138:Polytetrafluoroethylene; D006493:Heparin
keywords: Tibial and peroneal bypasses; critical limb ischemia