title: Engineered therapeutic-releasing nanoporous anodic alumina-aluminum wires with extended release of therapeutics.
abstract: In this study, we present a nanoengineered therapeutic-releasing system based on aluminum wires featuring nanoporous anodic alumina layers and chitosan coatings. Nanoporous anodic alumina layers are produced on the surface of aluminum wires by electrochemical anodization. These nanoporous layers with precisely engineered nanopore geometry are used as nanocontainers for bovine serum albumin molecules labeled with fluorescein isothiocyanate (BSA-FITC), which is selected as a model drug. The surface of these therapeutic-releasing implants is coated with a biocompatible and biodegradable polymer, chitosan, in order to achieve a sustained release of protein over extended periods of time. The performance of this therapeutic-releasing device is systematically assessed through a series of experiments under static and dynamic flow conditions. In these experiments, the effect of such parameters as the number of layers of chitosan coating and the temperature and pH of the eluting medium is established. The obtained results reveal that the proposed therapeutic-releasing system based on nanoporous aluminum wires can be engineered with sustained release performance for up to 6.5 weeks, which is a critical factor for medical treatments using sensitive therapeutics such as proteins and genes when a localized delivery is desired.
authors.affiliation: School of Chemical Engineering, The University of Adelaide , Adelaide, SA 5005, Australia.
authors.forename: Cheryl Suwen
authors.initials: CS
authors.lastname: Law
authors.forename: Abel
authors.initials: A
authors.lastname: Santos
authors.forename: Tushar
authors.initials: T
authors.lastname: Kumeria
authors.forename: Dusan
authors.initials: D
authors.lastname: Losic
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D058608:Nanopores; D053770:Nanowires / Q000737:chemistry*; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D000535:Aluminum; D000537:Aluminum Oxide
keywords: aluminum wires; chitosan coatings; nanoporous anodic alumina; simulated body conditions; therapeutic release