title: Treatment of painful diabetic peripheral neuropathy.
abstract: BACKGROUND
  Painful diabetic peripheral neuropathy impairs quality of life and can be difficult to treat.
  
  
  OBJECTIVE
  To discuss current treatment recommendations for painful diabetic peripheral neuropathy.
  
  
  METHODS
  Literature review.
  
  
  METHODS
  Systematic review of the literature discussing treatment of painful diabetic peripheral neuropathy. Existing treatment guidelines were studied and compared.
  
  
  RESULTS
  Painful diabetic peripheral neuropathy occurs in about one in six people with diabetes. This condition impairs quality of life and increases healthcare costs. Treatment recommendations exist, but individual patient therapy can require a trial-and-error approach. Many treatment options have adjuvant benefits or side effects which should be considered prior to initiating therapy. Often, a combination of treatment modalities with various mechanisms of action is required for adequate pain control. Adequate medication titration and a reasonable trial period should be allowed.
  
  
  CONCLUSIONS
  The treatment of painful diabetic peripheral neuropathy can be challenging, but effective management can improve patient's quality of life.
  
  
  CONCLUSIONS
  Painful diabetic peripheral neuropathy impairs quality of life and can be difficult to treat. Many treatment options have adjuvant benefits or side effects which should be considered prior to initiating therapy. Often, a combination of treatment modalities with various mechanisms of action is required for adequate pain control.
authors.affiliation: Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA c.rosenberg.md@gmail.com.
authors.forename: Casandra J
authors.initials: CJ
authors.lastname: Rosenberg
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Watson
mesh_terms: D000700:Analgesics / Q000009:adverse effects; D015928:Cognitive Behavioral Therapy; D003929:Diabetic Neuropathies / Q000628:therapy*; D004599:Electric Stimulation Therapy; D017408:Guidelines as Topic; D006801:Humans; D059408:Pain Management / Q000379:methods*; D011788:Quality of Life
chemical_list: D000700:Analgesics
keywords: Diabetes; diabetic peripheral neuropathy; neuropathy; painful neuropathy