title: Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study.
abstract: OBJECTIVE
  To demonstrate the inhibitory effects of clarithromycin on in vitro tympanosclerosis.
  
  
  METHODS
  Twenty-eight rats were divided into three groups: a clarithromycin group, a non-clarithromycin group and a negative control group. Those in the first two groups were injected with Streptococcus pneumoniae following a myringotomy, and tympanosclerosis was experimentally induced. Oral clarithromycin therapy was administered in the clarithromycin group. The other groups received no medical treatment.
  
  
  RESULTS
  All eardrums in the clarithromycin and non-clarithromycin groups developed myringosclerosis, but there was only one eardrum, in the clarithromycin group, with very severe myringosclerosis. In the clarithromycin group, 11 ears showed no inflammation and there were no ears with severe inflammation. In the non-clarithromycin group, there were 11 ears with severe inflammation. The mean eardrum thickness in the clarithromycin group was 20.93 µm and in the non-clarithromycin group it was 42.71 µm.
  
  
  CONCLUSIONS
  Acute otitis media and myringotomies induced tympanosclerosis, but clarithromycin reduced the severity of tympanosclerosis.
authors.affiliation: Department of Otolaryngology,School of Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Genc
authors.affiliation: Department of Otolaryngology,School of Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Koyuncu
authors.affiliation: Department of Otolaryngology,School of Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kutlar
authors.affiliation: Department of Pathology,Faculty of Veterinary Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Guvenc
authors.affiliation: Department of Pathology,Faculty of Veterinary Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Gacar
authors.affiliation: Department of Pharmacology and Toxicology,Faculty of Veterinary Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Aksoy
authors.affiliation: Department of Biometry,Faculty of Veterinary Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Department of Otolaryngology,School of Medicine,Ondokuz Mayis University,Samsun,Turkey.
authors.forename: S C
authors.initials: SC
authors.lastname: Kurnaz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D017291:Clarithromycin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004195:Disease Models, Animal; D016014:Linear Models; D008876:Middle Ear Ventilation / Q000009:adverse effects; D063371:Myringosclerosis / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D010033:Otitis Media / Q000188:drug therapy / Q000601:surgery; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D014432:Tympanic Membrane / Q000033:anatomy & histology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin
keywords: Otitis Media