title: Hyperthermia in the treatment of post-actinic osteosarcomas: our anecdotal experience.
abstract: Irradiation-induced sarcomas are a late sequelae of irradiation therapy. Most sarcomas have been reported to occur after exposure to a radiation dose of 55 Gys and above, with a dose ranging from 16 Gys to 112 Gys. These tumours are very aggressive and an early detection is needed for a timely intervention. Surgery is only effective treatment for local control instead chemotherapy is a valuable tool for systemic control of disease. Irradiation therapy use is controversial because of its side effects on a site previously irradiated. Irradiation therapy combined with hyperthermia is a new treatment that overcomes these problems without limiting the effect of radiation therapy. It may become a tool for local control of the unresectable tumours or an adjuvant treatment of the surgery. In this report we present a rare case of irradiation-induced recurrent osteosarcoma involving the chest wall that was treated with surgical resection followed by radiation therapy combined with hyperthermia as an adjuvant treatment of the surgery.
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tancredi
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ciuffreda
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Cuttitta
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy ; Graduate School of Medicine, Catholic University of the Sacred Heart - Largo Francesco Vito 1-00196 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Scaramuzzi
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy ; Graduate School of Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Sabatino
authors.affiliation: Unit of General Surgery 2 and Thoracic Surgery IRCCS "Casa Sollievo della Sofferenza" Hospital - Viale Cappuccini 1 -71013 San Giovanni Rotondo, FG, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Scaramuzzi
keywords: Hyperthermia; Radiation; Sarcoma