title: The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice.
abstract: The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A(1c)) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.
authors.affiliation: College of Food Science, Heilongjiang Bayi Agricultural University, China. byndycq@126.com.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Zang
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.forename: Kiharu
authors.initials: K
authors.lastname: Igarashi
authors.forename: Changqing
authors.initials: C
authors.lastname: Yu
mesh_terms: D050154:Adiposity; D000818:Animals; D019440:Anti-Obesity Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D006027:Glycosides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D007333:Insulin Resistance; D044949:Kaempferols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry* / Q000254:growth & development; D011897:Random Allocation; D013025:Glycine max / Q000737:chemistry* / Q000254:growth & development
chemical_list: D019440:Anti-Obesity Agents; D006442:Glycated Hemoglobin; D006027:Glycosides; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D044949:Kaempferols; D010936:Plant Extracts; C006552:kaempferol