title: Progressive encephalomyelitis with rigidity and myoclonus: anesthesia and glycine receptor antibodies.
abstract: Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare autoimmune neurological condition. Antibodies targeting glycine receptors (GlyR) have been implicated in PERM. Because GlyR activity is enhanced by inhaled anesthetic drugs at clinically relevant concentrations, there is a theoretical possibility that these drugs may be less effective in the presence of GlyR antibodies. We describe a case of general anesthesia in a patient with PERM and GlyR antibodies. This patient did not demonstrate a clinically significant alteration in the behavioral effects of anesthesia using induction of anesthesia with sevoflurane and maintenance of anesthesia using sevoflurane and nitrous oxide.
authors.affiliation: From the Department of Anesthesia, Worthing Hospital, Worthing, United Kingdom.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Papadopoulou
authors.forename: Theophilus Luke
authors.initials: TL
authors.lastname: Samuels
authors.forename: Asitha
authors.initials: A
authors.lastname: Dassanayake
authors.forename: Colin
authors.initials: C
authors.lastname: Spring
authors.forename: Johann
authors.initials: J
authors.lastname: Willers
authors.forename: David Roy
authors.initials: DR
authors.lastname: Uncles