title: Plant GSTome: structure and functional role in xenome network and plant stress response.
abstract: Glutathione transferases (GSTs) represent a major group of detoxification enzymes. All plants possess multiple cytosolic GSTs, each of which displays distinct catalytic as well as non-catalytic binding properties. The progress made in recent years in the fields of genomics, proteomics and protein crystallography of GSTs, coupled with studies on their molecular evolution, diversity and substrate specificity has provided new insights into the function of these enzymes. In plants, GSTs appear to be implicated in an array of different functions, including detoxification of xenobiotics and endobiotics, primary and secondary metabolism, stress tolerance, and cell signalling. This review focuses on plant GSTome and attempts to give an overview of its catalytic and functional role in xenome and plant stress regulatory networks.
authors.affiliation: Laboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 75 Iera Odos Street, GR-11855 Athens, Greece. Electronic address: lambrou@aua.gr.
authors.forename: Nikolaos E
authors.initials: NE
authors.lastname: Labrou
authors.affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku 20521, Finland.
authors.forename: Anastassios C
authors.initials: AC
authors.lastname: Papageorgiou
authors.affiliation: University of Thessaly, School of Agricultural Sciences, Department of Agriculture, Crop Production and Rural Environment, Fytokoy Street, 384 46 N. Ionia, Magnisia, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Pavli
authors.affiliation: Laboratory of Molecular Biology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, Greece.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Flemetakis
mesh_terms: D000818:Animals; D055162:Biocatalysis; D023281:Genomics; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010944:Plants / Q000201:enzymology* / Q000235:genetics*; D013312:Stress, Physiological; D013379:Substrate Specificity
chemical_list: D005982:Glutathione Transferase