title: [Significance and expressions of BRCA1 and BRCA2 protein in sporadic breast cancer].
abstract: OBJECTIVE
  To explore the role of expressions of BRCA1 and BRCA2 protein in sporadic breast cancer.
  
  
  METHODS
  Eighty-six cases of breast cancer and adjacent cancer tissues and 48 cases of breast hyperplasia surgical specimens were collected. And the immunohistochemical S-P method was employed for detecting the protein expressions of BRCA1 and BRCA2.
  
  
  RESULTS
  BRCA1 expression in breast cancer, breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 60.5% (52/86), 46.5% (40/86) and 100% (48/48). The difference was significant among three groups. The BRCA2 expression in breast cancer, breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 41.9% (36/86), 55.8% (48/86) and 95.8% (46/48) respectively. And the difference was significant among three groups. The expression of BRCA1 had no obvious relation with BRCA2 protein in breast cancer tissues (r = 0.673, P > 0.05).
  
  
  CONCLUSIONS
  The aberrant expressions of BRCA1 and BRCA2 protein plays a major role in the occurrence and progression of sporadic breast cancer.
authors.affiliation: Department of Surgical Oncology, Affiliated Hospital of Inner Mongolia, Huhhot 010050, China. Email: meihuayani@sina.com.
authors.forename: Jinzhu
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Surgical Oncology, Affiliated Hospital of Inner Mongolia, Huhhot 010050, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D001943:Breast Neoplasms; D006801:Humans
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human