title: In vivo evaluation of Fe₃O₄ nanoparticles.
abstract: Our review summarizes the latest approaches regarding in vivo biocompatibility evaluation of magnetite nanoparticle-based systems. The paper follows the applications of Fe3O4 nanoparticles in cancer diagnosis and treatment, by means of nanoparticle-mediated magnetic hyperthermia, respectively by targeted delivery of chemotherapeutics. The long-term biodistribution in relevant organisms is also discussed, due to the need of knowing the exact course of magnetite nanoparticles after the fulfillment of their function. Several commercial Fe3O4 systems used as contrast agents for medical imaging and cancer treatment by hyperthermia are briefly presented in the last section.
authors.affiliation: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; grumezescu@yahoo.com.
authors.forename: Roxana Cristina
authors.initials: RC
authors.lastname: Popescu
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
mesh_terms: D000818:Animals; D005290:Ferric Compounds; D006801:Humans; D006979:Hyperthermia, Induced; D058185:Magnetite Nanoparticles; D008422:Materials Testing; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D014018:Tissue Distribution
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide