title: Regioselective direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates promoted by palladium-phosphine complexes.
abstract: Direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates has been accomplished by employing palladium(II) acetate associated with SPhos (2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl) or L1 (2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole). This catalyst system can be applied to a wide range of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine. These results represent the first examples of using tosylate- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct arylation.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong.
authors.forename: Pui Ying
authors.initials: PY
authors.lastname: Choy
authors.forename: Kwan Chak
authors.initials: KC
authors.lastname: Luk
authors.forename: Yinuo
authors.initials: Y
authors.lastname: Wu
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Lai-lai
authors.initials: LL
authors.lastname: Wang
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D007211:Indoles / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: C000600232:(2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole); D007211:Indoles; D008698:Mesylates; D009942:Organometallic Compounds; D011725:Pyridines; D014105:Tosyl Compounds; D010165:Palladium