title: Burden of fungal disease in Ireland.
abstract: Our objective was to estimate the burden of fungal disease on the island of Ireland, as part of a coordinated project estimating the global burden. Published epidemiology data describing fungal infection in Ireland were identified. Population and underlying disease data were collected for 2010 and a structured set of assumptions were applied to estimate burden of fungal disease based on immunosuppression, chronic disease, and other demographic information indicating predisposition to fungal infection. From Ireland's population of 6.4 million, we estimate 117, 000 patients develop significant fungal disease each year. By far the most common fungal disease is recurrent Candida vaginitis, with an estimated 95, 000 episodes annually (3000 per 100 000 women). Other fungal diseases which may be less well recognized are severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis, with estimated episodes per year of 11, 700 and 9000, respectively (182 and 140 per 100, 000 population, respectively). The model also estimates 450 episodes of invasive aspergillosis, 200 of chronic pulmonary aspergillosis, 600 of oesophageal candidiasis and 450 of candidaemia per year (7, 3, 9 and 6 episodes per 100, 000 population, respectively). This is, we believe, the first attempt to estimate the burden of fungal disease in our population and provides a basis for estimating its impact on human health and resource use.
authors.affiliation: Department of Medical Microbiology, Belfast HSC Trust, Belfast, UK.
authors.forename: Eileen
authors.initials: E
authors.lastname: Dorgan
authors.affiliation: University of Manchester, Education and Research Centre, Southmoor Road Manchester M23 9LT.
authors.forename: David W
authors.initials: DW
authors.lastname: Denning
authors.affiliation: Centre for Infection and Immunity, Queens University Belfast, UK.|Department of Medical Microbiology, Belfast HSC Trust, Belfast, UK.
authors.forename: Ronan
authors.initials: R
authors.lastname: McMullan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009181:Mycoses / Q000453:epidemiology*; D055815:Young Adult