title: Binge eating disorder and obesity: preliminary evidence for distinct cardiovascular and psychological phenotypes.
abstract: This study investigated cardiovascular functioning, mood, and eating-related psychological factors at rest and in response to mental stress in three groups of women: 1) Obese women with binge eating disorder (BED; n=9); 2) obese non-BED women (n=15); and 3) normal weight (NW) non-BED women (n=15). Compared to both obese and NW non-BED women, obese women with BED showed heightened overall blood pressure and reported greater depression symptoms, perceived stress, and eating-related psychopathology. Additionally, obese women with BED reported greater overall negative affect and state anxiety compared to obese non-BED women. The heart rate response to stress was blunted in the obese BED group compared to the other groups, but this effect was no longer significant after controlling for baseline differences in depression. Correlational analyses revealed a positive association between stress-induced changes in hunger and cardiovascular measures only in obese women with BED. Longitudinal studies are needed to determine if stress dysregulation and stress-induced increases in hunger contribute to the onset and/or maintenance of BED. In particular, studies utilizing an additional NW BED control group are warranted in order to further examine the impact of BED above and beyond the impact of obesity on psychophysiological functioning and to inform the growing literature regarding stress-related factors that distinguish the BED and obesity phenotypes.
authors.affiliation: Department of Psychology, Rhodes College, TN, USA. Electronic address: klatzkinr@rhodes.edu.
authors.forename: Rebecca R
authors.initials: RR
authors.lastname: Klatzkin
authors.affiliation: Department of Psychology, Rhodes College, TN, USA.
authors.forename: Sierra
authors.initials: S
authors.lastname: Gaffney
authors.affiliation: Department of Psychology, Rhodes College, TN, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Cyrus
authors.affiliation: Department of Psychology, Rhodes College, TN, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bigus
authors.affiliation: Department of Psychiatry, The University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Brownley
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D056912:Binge-Eating Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D003863:Depression / Q000503:physiopathology; D005247:Feeding Behavior; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006815:Hunger / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D009765:Obesity / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D057566:Self Report; D013315:Stress, Psychological / Q000503:physiopathology; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D003278:Contraceptives, Oral, Hormonal
keywords: Binge eating disorder; Cardiovascular; Hunger; Obesity; Stress