title: [Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia].
abstract: OBJECTIVE
  To explore the efficacy and safety of vitamin D (VD) in the treatment of idiopathic oligoasthenozoospermia.
  
  
  METHODS
  This study included 86 infertile men with idiopathic oligoasthenozoospermia, who were randomized to a VD and a control group of equal number, the former given oral VD 200 IU/d and calcium 600 mg/d,qd, while the latter administered oral vitamin E 100 mg and vitamin C 100 mg, tid. After 3 months of medication, we compared the semen parameters, adverse reactions, and pregnancy rate between the two groups.
  
  
  RESULTS
  After medication, the count of progressively motile sperm per ejaculate was increased from (9.82 ± 3.72) x 10(6) to (21.47 ± 6.52) x 10(6) ( P < 0.05) and the proportion of progressively motile sperm from (18.41 ± 9.82)% to (28.27 ± 4.47)% (P < 0.05) in the VD group. In comparison, the count of progressively motile sperm per ejaculate was elevated from (9.51 ± 6.31) x 10(6) to (12.36 ± 4.43) x 10(6) (P > 0.05) and the proportion of progressively motile sperm from (17.79 ± 5.25)% to (21.35 ± 2.41)% (P > 0.05) in the control group. Pregnancy was achieved in 7 cases (16.3%) in the VD group, but only lease (2.3%) in the control (P < 0.05). No adverse reactions were observed in either of the groups.
  
  
  CONCLUSIONS
  Vitamin D, as a safe option for the treatment of idiopathic oligoasthenozoospermia, can effectively improve the semen quality, especially the progressive sperm motility of the patient.
authors.affiliation: Department of Urology, Ganzhou People's Hospital/Ganzhou  Hospital affiliated to Nanchang University, Jiangxi, China. dengxiaolin@hsc.pku.edu.cn
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Deng
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Huang
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Guo
authors.forename: Le-Ming
authors.initials: LM
authors.lastname: Song
mesh_terms: D000284:Administration, Oral; D000328:Adult; D053627:Asthenozoospermia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012661:Semen / Q000187:drug effects / Q000502:physiology; D055101:Semen Analysis; D013081:Sperm Motility / Q000187:drug effects; D014807:Vitamin D / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014807:Vitamin D; D014810:Vitamin E