title: Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.
abstract: A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, Jiangsu, China.
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.forename: Nan
authors.initials: N
authors.lastname: Zheng
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002470:Cell Survival / Q000187:drug effects; D057930:Click Chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy*; D008358:Mannose / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D004317:Doxorubicin; D008358:Mannose
keywords: O-carbyxyanhydride; micelles; polyesters; ring-opening polymerization; targeted drug delivery