title: Attenuation of cisplathin-induced toxic oxidative stress by propofol.
abstract: BACKGROUND
  Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat.
  
  
  OBJECTIVE
  In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both.
  
  
  METHODS
  G‎roup one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m‎arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant ‎capacity (TAC) were measured.
  
  
  RESULTS
  Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered ‎cisplatin -induced changes in TAC, TTG and LPO in blood.
  
  
  CONCLUSIONS
  It is concluded that oxidative ‎damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.‎
authors.affiliation: Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Taheri Moghadam
authors.affiliation: Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed-Mostafa
authors.initials: SM
authors.lastname: Hosseini-Zijoud
authors.affiliation: Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan ‎University of Medical Sciences, Hamadan, Iran.
authors.forename: Tavakol
authors.initials: T
authors.lastname: Heidary Shayesteh
authors.affiliation: Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ghasemi
authors.affiliation: Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan ‎University of Medical Sciences, Hamadan, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Ranjbar
keywords: Cisplatin; Oxibdative stress; Propofol; Rat