title: Energy metabolism disorders in rat salivary glands tissues in connection with chronic sodium nitrate intoxication.
abstract: The purpose of the research was the study of nitrite impact on energy metabolism in salivary gland tissues in connection with chronic nitrate intoxication. The study has been carried out on 100 Wistar rats, weighing 160-250 g, which were divided into following groups: the 1st group consisted of intact rodents (control); the 2nd group consisted of experimental rodents, where chronic nitrate intoxication has been reproduced during 14, 30, 60 and 90 days. Intoxication leads to hypoxia, which complications cause tissue hypoxia. Has been established that prolonged intake of nitrates in low doses leads to their accumulation in salivary glands tissues all these result in derangement of metabolism at the intermembrane cellular level. At the same time energy metabolism in salivary glands is inhibited, resulting in their dysfunction at the excretory and endocrine levels.
authors.affiliation: Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: D
authors.initials: D
authors.lastname: Avetikov
authors.affiliation: Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Bondarenko
authors.affiliation: Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: S
authors.initials: S
authors.lastname: Danylchenko
authors.affiliation: Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Pronina
authors.affiliation: Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.
authors.forename: S
authors.initials: S
authors.lastname: Stavytskyi
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology*; D008659:Metabolic Diseases / Q000139:chemically induced / Q000503:physiopathology*; D009566:Nitrates / Q000633:toxicity*; D051381:Rats; D012469:Salivary Glands / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D009566:Nitrates; C031618:sodium nitrate