title: Cerebral Venous Thrombosis and Pulmonary Embolism with Prothrombin G20210A Gene Mutation.
abstract: A 25-year-old man presented with symptoms of syncope, cough, headache and hemoptysis. Cranial MR and venography showed thrombus formation in the right transverse sinus and superior sagittal sinus. Computed tomographic pulmonary angiography (CTPA) showed an embolic thrombus in the right pulmonary truncus and lung abscess. The patient was young, and there were no signs of lower extremity deep venous thrombosis or other major risk factors for pulmonary embolism (PE) including cardiac anomaly. The only risk factor we were able to identify was the presence of the prothrombin G20210A gene mutation. Anticoagulant treatment with oral warfarin (10 mg daily) and imipenem (4X500 mg) was started. The patient was hospitalized for antibiotic and anticoagulation therapies for three weeks and was discharged on lifelong treatment with warfarin (5 mg daily).
authors.affiliation: Department of Pulmonology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey.
authors.forename: Canan Eren
authors.initials: CE
authors.lastname: Dagli
authors.affiliation: Department of Pulmonology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Koksal
authors.affiliation: Department of Infectious Diseases, Kahramanmaras Yenisehir State Hospital, Kahramanmaras,Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Guler
authors.affiliation: Department of Pulmonology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Gelen
authors.affiliation: Department of Pulmonology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Atilla
authors.affiliation: Department of Neurology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Tuncel
keywords: Prothrombin G20210A gene mutation; cerebral venous thrombosis; pulmonary embolism