title: [LDL-apheresis in the treatment familial hypercholesterolemia].
abstract: LDL-apheresis is an extracorporeal elimination technique, which specifically removes LDL-cholesterol from the circulation. There are six methods for the selective LDL-cholesterol removal these days. The main indications for LDL-apheresis are the diagnosis of homozygous familial hypercholesterolemia, heterozygous familial hypercholesterolemia which is refractory the standard care and intolerance of routine care, and also patients with lipoprotein(a) increase resistant to the farmacotherapy. There is still debate which LDL-cholesterolemia is indication for LDL-apheresis therapy, and the recommendation differs among various countries. Despite large randomized trials are missing, there are several good quality studies to conclude, that the beneficial cardiovascular effects of LDL-apheresis in severe hypercholesterolemia are important and beneficial.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Bláha
authors.forename: Milan
authors.initials: M
authors.lastname: Bláha
authors.forename: Miriam
authors.initials: M
authors.lastname: Lánská
authors.forename: Eduard
authors.initials: E
authors.lastname: Havel
authors.forename: Pavel
authors.initials: P
authors.lastname: Vyroubal
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Zadák
authors.forename: Pavel
authors.initials: P
authors.lastname: Žák
authors.forename: Luboš
authors.initials: L
authors.lastname: Sobotka
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000628:therapy*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides