title: Long-range gene regulation and novel therapeutic applications.
abstract: An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.
authors.affiliation: Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
authors.forename: Anita
authors.initials: A
authors.lastname: van den Heuvel
authors.affiliation: Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
authors.forename: Ralph
authors.initials: R
authors.lastname: Stadhouders
authors.affiliation: INSERM UMRS 1138, Team 17, Paris, France; and.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Andrieu-Soler
authors.affiliation: Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
authors.forename: Frank
authors.initials: F
authors.lastname: Grosveld
authors.affiliation: INSERM UMR967, CEA/DSV/iRCM, Laboratory of Molecular Hematopoiesis, Fontenay-aux-Roses, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Soler
mesh_terms: D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D015894:Genome, Human; D006801:Humans; D017393:RNA Editing; D050436:Regulatory Elements, Transcriptional