title: Design, Synthesis, and Biological Evaluation of γ-Aminopropyl Silatrane-Acyclovir Hybrids with Immunomodulatory Effects.
abstract: Several derivatives of γ-aminopropyl silatrane containing acyclovir in their molecular structure were synthesized and evaluated for their immunomodulatory and antiviral activities. The structures of all these derivatives were confirmed by mass spectra, IR, and (1) H NMR. Based on WST-1 assay in vitro, these compounds could stimulate proliferation of splenic lymphocytes at certain concentrations. Furthermore, compound 3d could also potentiate the expression of IFN-γ, IL-2, CD4(+) , CD8(+) , and CD4(+) /CD8(+) in vivo. Our results show that these derivatives possess antiviral activity against herpes simplex viruses with a similar potency to acyclovir without a cellular immune response.
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Faqing
authors.initials: F
authors.lastname: Ye
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Song
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, Zhejiang, 325000, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Yuewu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, China.
authors.forename: Lichuan
authors.initials: L
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Liang
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
authors.forename: Zixin
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D015195:Drug Design; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D008807:Mice, Inbred BALB C; D017646:Organosilicon Compounds / Q000737:chemistry* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007155:Immunologic Factors; D007376:Interleukin-2; D017646:Organosilicon Compounds; C015503:silatrane; D007371:Interferon-gamma; D000212:Acyclovir
keywords: acyclovir derivant; immunomodulatory activity; γ-aminopropyl silatrane