title: [Epigenetics: a novel tool for early diagnosis and tumor therapy].
abstract: Epigenetics, first described by Conrad Waddington, defines how pathways setting a specific phenotype and heritable cellular functions are activated in a DNA independent way. Epigenetics concerns the study of genome structure and accessibility that regulates patterns of gene expression through the dynamic compaction and opening the chromatin structure. Vincent Allfrey profetically declared in 1964 that histone modifications could influence gene expression. In cancer very often cells show a profound modification of DNA methylation and mutations in chromatin regulators. These evidences provided therefore a clear link between epigenetics and neoplasia. Advanced molecular technology such as Deep-sequencing and ChIP-Seq revealed the frequent relocalization in cancer of many PTM readers such the Ac-Lys binding bromodomain. These results were important for the development of novel classes of epigenetic drugs some of which are inhibitors of histone modifyers or molecule interacting with reader domains. Since cancer imply profound changes in the epigenetic profile and in gene transcription a future challenge of molecular and chemical biology will be to develop novel epigenetic compounds able to correct the epigenetic disfunction and, possibly, coadiuvate canonical therapy in the cure of cancer.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Filetici
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002843:Chromatin / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D042241:Early Diagnosis; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation; D023281:Genomics; D006657:Histones / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D002843:Chromatin; D006657:Histones