title: Three new labdane-type diterpene glycosides from fruits of Rubus chingii and their cytotoxic activities against five humor cell lines.
abstract: Three new labdane-type diterpene glycosides, 15,18-di-O-β-d-glucopyranosyl-13(E)-ent-labda-7(8),13(14)-diene-3β,15,18-triol (1), 15,18-di-O-β-d-glucopyranosyl-13(E)-ent-labda-8(9),13(14)-diene-3β,15,18-triol (2), and 15-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranosyl-18-O-β-d-glucopyranosyl-13(E)-ent-labda-8(9),13(14)-diene-3β,15,18-triol (3), were isolated from the fruits of Rubus chingii. Their structures were elucidated on the basis of spectroscopic data and chemical methods. The cytotoxic activities of compounds 1-3 were evaluated against five human tumor cell lines (HCT-8, BGC-823, A549, and A2780). Compounds 3 showed cytotoxic activity against A549 with an IC50 value of 2.32μM.
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, China.
authors.forename: Ruijian
authors.initials: R
authors.lastname: Zhong
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, China. Electronic address: fhzfhz620@sohu.com.
authors.forename: Huizheng
authors.initials: H
authors.lastname: Fu
authors.affiliation: Drug Adverse Reaction Monitoring Center of Jiangxi, Nanchang 330046, China. Electronic address: kk2008317@163.com.
authors.forename: Kaihua
authors.initials: K
authors.lastname: Wan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D065856:Rubus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D006027:Glycosides; C433017:labdane
keywords: Cytotoxic activity; Diterpene glycosides; Labdane-type; Rubus chingii