title: Role of Krüppel-like factors in cancer stem cells.
abstract: Cancer stem cells (CSCs), or cancer cells with stem cell properties, are a rare population of tumor bulk and are recognized to be responsible for cancer recurrence, drug resistance, and metastasis. However, the molecular mechanisms of how to regulate the differentiation and self-renewing of CSCs are poorly understood. Krüppel-like factors (KLFs) are essential DNA-binding transcriptional regulators with diverse functions in various cellular processes, including differentiation, proliferation, inflammation, migration, and pluripotency. Recent progress has highlighted the significance of KLFs in tumor progression and CSCs. The regulatory functions of KLFs in the development of cancer and CSCs have become a burgeoning area of intense research. In this review, we summarize the current understanding and progress of the transcriptional regulation of KLFs in CSCs and discuss the functional implications of targeting CSCs by KLFs for cancer therapeutics.
authors.affiliation: Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, #14, 3rd section of Renmin South Road, Chengdu, 610041, China.
authors.forename: Yueling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Hao
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Dian
authors.initials: D
authors.lastname: Jing
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010802:Phylogeny
chemical_list: D051741:Kruppel-Like Transcription Factors