title: Tolerance of benznidazole in a United States Chagas Disease clinic.
abstract: The US-based Center of Excellence for Chagas Disease performed an observational study on the safety and tolerance of benznidazole 5 mg/kg/day for 60 days in 30 adults with chronic Chagas disease. The side-effect profile was suboptimal, including 5 cases of debilitating neuropathy and an unusually high angioedema rate.
authors.affiliation: Los Angeles Biomedical Research Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance.
authors.forename: David A
authors.initials: DA
authors.lastname: Miller
authors.affiliation: Center of Excellence for Chagas Disease, Olive View-UCLA Medical Center, Sylmar, California.
authors.forename: Salvador
authors.initials: S
authors.lastname: Hernandez
authors.affiliation: Center of Excellence for Chagas Disease, Olive View-UCLA Medical Center, Sylmar, California.
authors.forename: Lissette
authors.initials: L
authors.lastname: Rodriguez De Armas
authors.affiliation: Los Angeles Biomedical Research Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Eells
authors.affiliation: Center of Excellence for Chagas Disease, Olive View-UCLA Medical Center, Sylmar, California.
authors.forename: Mahmoud M
authors.initials: MM
authors.lastname: Traina
authors.affiliation: Los Angeles Biomedical Research Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance.
authors.forename: Loren G
authors.initials: LG
authors.lastname: Miller
authors.affiliation: Center of Excellence for Chagas Disease, Olive View-UCLA Medical Center, Sylmar, California.
authors.forename: Sheba K
authors.initials: SK
authors.lastname: Meymandi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000799:Angioedema / Q000139:chemically induced / Q000453:epidemiology; D014355:Chagas Disease / Q000188:drug therapy*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000453:epidemiology; D012189:Retrospective Studies; D014344:Trypanocidal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014481:United States; D055815:Young Adult
chemical_list: D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole
keywords: Chagas disease; United States; benznidazole; drug tolerance; trypanosomiasis