title: Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people.
abstract: BACKGROUND
  MLL5, a member of the histone-lysine N-methyltransferase family, has been implicated in the control of the cell cycle progression and survival. The aim of this study was to explore the relationship between the interaction of histone-lysine N-methyltransferase MLL5 gene polymorphism and CAD in a Chinese Han population.
  
  
  METHODS
  Using a case-control study of Chinese CAD patients (n = 565) and healthy controls (n = 694), we investigated the MLL5 gene polymorphism by the use of polymerase chain reaction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  For total, the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) genotypes showed a significant difference between CAD and control participants (P1 = 0.03, P2 = 0.02). For total the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) alleles in the dominant model (GG vs. AA + AG) and the recessive model (AA vs. AG + GG) showed a significant difference between CAD and control participants (for allele: P1 < 0.01 and P2 = 0.05, for dominant model: P1 > 0.05 and P2 = 0.02, for recessive model: P1 = 0.03 and P2 = 0.78, respectively). For total the significant difference of the distribution of SNP1 and SNP2 in the dominant model and recessive model was retained after adjusting for covariates (for dominant model: SNP1 OR: 1.68, 95% confidence interval [CI]: 1.08-2.64, P = 0.02; SNP2 OR: 0.51, 95% CI: 0.36-0.72, P = 0.01; for recessive model: SNP1 OR: 1.84, 95% confidence interval [CI]: 1.28-2.64, P < 0.01; SNP2 OR: 0.65, 95% CI: 0.35-1.22, P = 0.18).
  
  
  CONCLUSIONS
  The GG genotype of rs12671368 and the AA genotype of rs2192932 in the MLL5 gene could be protective genetic markers of CAD.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China.
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Chuanfang
authors.initials: C
authors.lastname: Dai
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China ; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, PR China.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
keywords: Case–control study; Coronary artery disease; MLL5; Single nucleotide polymorphism