title: Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.
abstract: A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 104 RAL, 600 S. Mathews Ave., Urbana, IL, 61801, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Caliari
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Weisgerber
authors.forename: William K
authors.initials: WK
authors.lastname: Grier
authors.forename: Ziad
authors.initials: Z
authors.lastname: Mahmassani
authors.forename: Marni D
authors.initials: MD
authors.lastname: Boppart
authors.forename: Brendan A C
authors.initials: BA
authors.lastname: Harley
mesh_terms: D001842:Bone and Bones / Q000502:physiology*; D003094:Collagen / Q000737:chemistry*; D006801:Humans; D013710:Tendons / Q000502:physiology*; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D003094:Collagen
keywords: bone; collagen; mesenchymal stem cells; orthopedic interfaces; tendon