title: Mismatch negativity indices of enhanced preattentive automatic processing in panic disorder as measured by a multi-feature paradigm.
abstract: Panic disorder (PD) is a mental disorder characterized by recurrent panic attacks and worrying about having subsequent attacks. Mismatch negativity (MMN) has been established as a correlate of preattentive automatic processing. The aim of the present study is to investigate the preattentive automatic information processing in PD patients as measured by MMN. Subjects included 15 medication-free patients with a DSM-IV diagnosis of PD and 15 age-matched healthy volunteers. MMN was investigated using event-related potentials. The protocol used a multi-feature paradigm. Mean amplitudes and peak latencies were subjected to repeated-measures ANOVAs. PD patients showed a significantly increased MMN of sound intensity and location compared with healthy participants. The correlation between the amplitudes of intensity-MMN and disease severity was also significant. These data provide evidence of anomalous preattentive automatic information processing in PD patients. In particular, the abnormality may be specific for PD.
authors.affiliation: Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China; Research Institute of Integrated Traditional and Western Medicine of Dalian Medical University, Dalian, Liaoning Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China; Research Institute of Integrated Traditional and Western Medicine of Dalian Medical University, Dalian, Liaoning Province, China. Electronic address: xujing_doc@aliyun.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China; Research Institute of Integrated Traditional and Western Medicine of Dalian Medical University, Dalian, Liaoning Province, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Psychology, Dalian Medical University, Dalian, Liaoning Province, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning Province, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000503:physiopathology*; D013017:Sound Localization / Q000502:physiology*; D055815:Young Adult
keywords: Anxiety; Automatic processing; Event-related potential; MMN; Panic disorder; Preattention