title: No Effect on Body Dissatisfaction of an Interaction between 5-HTTLPR Genotype and Neuroticism in a Young Adult Korean Population.
abstract: OBJECTIVE
  Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPR genotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by body dissatisfaction in a young adult Korean population.
  
  
  METHODS
  Two hundred and eighty three subjects were included in this study. The Eysenck Personality Questionnaire-Korean version was used to evaluate neuroticism, the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)-Korean version was used to evaluate body dissatisfaction, and the Self-Esteem Scale (SES)-Korean version was used to evaluate self-esteem. The 5-HTTLPR genotype by neuroticism (high : low) interaction was assessed according to the total BDDE-SR score, and 5-HTTLPR genotype by BDDE-SR (high : low) interaction was assessed according to the total SES score.
  
  
  RESULTS
  The analysis of 5-HTTLPR genotype and neuroticism (high : low) with respect to body dissatisfaction showed no main effects of genotype whereas neuroticism did influence the BDDE-SR score and no interaction of the genotype with neuroticism. The analysis of 5-HTTLPR genotype and BDDE-SR (high : low) with respect to self-esteem score showed no main effects of genotype whereas BDDE-SR did influence the self-esteem score and no interaction of the genotype with body dissatisfaction.
  
  
  CONCLUSIONS
  These results suggest that an interaction between 5-HTTPLR genotype and neuroticism does not affect body dissatisfaction and an interaction between 5-HTTPLR genotype and body dissatisfaction does not affect self-esteem in a young adult Korean population.
authors.affiliation: Department of Psychiatry, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. ; Institute of Brain Research, Chungnam National University, Daejeon, Korea.
authors.forename: Seung-Keun
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Department of Anatomy, Chungnam National University School of Medicine, Daejeon, Korea. ; Institute of Brain Research, Chungnam National University, Daejeon, Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. ; Institute of Brain Research, Chungnam National University, Daejeon, Korea.
authors.forename: Jeong-Lan
authors.initials: JL
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. ; Institute of Brain Research, Chungnam National University, Daejeon, Korea.
authors.forename: Ik-Seung
authors.initials: IS
authors.lastname: Chee
keywords: 5-HTTLPR; Body dissatisfaction; Neuroticism; Self-esteem