title: The healing effect of curcumin on burn wounds in rat.
abstract: BACKGROUND
  Burns are still considered one of the most devastating conditions in emergency medicine affecting both genders and all age groups in developed and developing countries, resulting into physical and psychological scars and cause chronic disabilities. This study was performed to determine the healing effect of curcumin on burn wounds in rat.
  
  
  METHODS
  Seventy female Sprague-Dawley 180-220 g rats were randomly divided into 5 equal groups. Groups of A-C received 0.1, 0.5 and 2% curcumin respectively and Group D, silver sulfadiazine ointment. Group E was considered as control group and received eucerin. After 7, 14 and 21 days of therapy, the animals were sacrificed and burn areas were macroscopically examined and histologically were scored.
  
  
  RESULTS
  Administration of curcumin resulted into a decrease in size of the burn wounds and a reduction in inflammation after 14(th) days. Reepithelialization was prominent in groups A-C while more distinguishable in group C. In group C, epidermis exhibited well structured layers without any crusting. There were spindle shaped fibroblasts in fascicular pattern, oriented parallel to the epithelial surface with eosinophilic collagen matrix.
  
  
  CONCLUSIONS
  Curcumin as an available and inexpensive herbal was shown be a suitable substitute in healing of burn wounds especially when 2% concentration was applied.
authors.affiliation: Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
authors.affiliation: Department of Medical Pharmacology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran;
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Farjam
authors.affiliation: Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; ; Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
authors.affiliation: Laparascopy Research Center, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Amini
authors.affiliation: Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Panjehshahin
keywords: Burn; Curcumin; Healing; Rat; Wound