title: drexplorer: A tool to explore dose-response relationships and drug-drug interactions.
abstract: Nonlinear dose-response models are primary tools for estimating the potency [e.g. half-maximum inhibitory concentration (IC) known as IC50] of anti-cancer drugs. We present drexplorer software, which enables biologists to evaluate replicate reproducibility, detect outlier data points, fit different models, select the best model, estimate IC values at different percentiles and assess drug-drug interactions. drexplorer serves as a computation engine within the R environment and a graphical interface for users who do not have programming backgrounds.
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Pan
authors.initials: P
authors.lastname: Tong
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Coombes
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Faye M
authors.initials: FM
authors.lastname: Johnson
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Byers
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Lixia
authors.initials: L
authors.lastname: Diao
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Diane D
authors.initials: DD
authors.lastname: Liu
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: J Jack
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: John V
authors.initials: JV
authors.lastname: Heymach
authors.affiliation: Departments of Bioinformatics and Computational Biology, Houston, TX 77030, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D020128:Inhibitory Concentration 50; D017711:Nonlinear Dynamics; D015203:Reproducibility of Results; D012984:Software
chemical_list: D000970:Antineoplastic Agents