title: Vesicular stomatitis virus-based vaccines against Lassa and Ebola viruses.
abstract: We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marzi
authors.forename: Friederike
authors.initials: F
authors.lastname: Feldmann
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Geisbert
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
authors.forename: David
authors.initials: D
authors.lastname: Safronetz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000276:immunology*; D005822:Genetic Vectors; D019142:Hemorrhagic Fever, Ebola / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D007835:Lassa Fever / Q000401:mortality / Q000517:prevention & control*; D007836:Lassa virus / Q000276:immunology*; D008252:Macaca fascicularis; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D014614:Vaccines, Synthetic; D014765:Viral Vaccines