title: White matter alterations are associated with suicide attempt in patients with panic disorder.
abstract: BACKGROUND
  Panic disorder (PD) is associated with an increased risk of suicide attempt (SA). However, no study has examined the neural correlates of SA in PD. The goal of this study was to evaluate alterations in white matter (WM) and gray matter (GM) in patients with PD with and without a history of SA.
  
  
  METHODS
  Twelve patients with PD and a history of SA (PD+SA) and 24 patients with PD and no history of SA (PD-SA) underwent magnetic resonance imaging (MRI). All patients completed the Scale for Suicide Ideation (SSI), the Panic Disorder Severity Scale (PDSS), and the Beck Depression Inventory (BDI). The groups were matched for age, sex, and BDI and PDSS scores. Voxel-based morphometry and tract-based spatial statistics were used for the imaging analysis.
  
  
  RESULTS
  Although no GM or WM volume differences were observed, increased fractional anisotropy (FA) values were found in the WM tracts of the PD+SA group compared with the PD-SA group. The regions with increased FA included the internal capsule, splenium of the corpus callosum, superior and posterior corona radiata, thalamic radiations, sagittal stratum, and superior longitudinal fasciculus. The FA values for the internal capsule and thalamic radiations were significantly correlated with the SSI scores in the PD+SA group.
  
  
  CONCLUSIONS
  The results should be considered preliminary due to the relatively small sample size.
  
  
  CONCLUSIONS
  Our data suggest that the aberrant WM integrity of the internal capsule and thalamic radiations may be the significant neural correlate of SA in patients with PD.
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Borah
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Jongsoo
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Sungjae
authors.initials: S
authors.lastname: Lee
authors.affiliation: Neuroscience Research Institute, Kangwon National University Hospital, Chuncheon, Republic of Korea.
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.affiliation: Department of Business Administration, Kwangwoon University, Seoul, Republic of Korea.
authors.forename: Chan Mo
authors.initials: CM
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Tai Kiu
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. Electronic address: leesanghyuk@yahoo.com.
authors.forename: Sang-Hyuk
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D020772:Internal Capsule / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology; D016584:Panic Disorder / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data; D066127:White Matter / Q000473:pathology*
keywords: Attempted suicide; Corpus callosum; Internal capsule; Panic disorder; Thalamus; White matter