title: Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin.
abstract: BACKGROUND
  Salvia miltiorrhiza Bge. (Labiatae) has been widely used for treating diabetes for centuries. Salvianolic acid B (SalB) is the main bioactive component in Salvia miltiorrhiza; however, its antidiabetic activity and possible mechanism are not yet clear.
  
  
  OBJECTIVE
  To investigate the effects of SalB on glycometabolism, lipid metabolism, insulin resistance, oxidative stress, and glycogen synthesis in type 2 diabetic rat model.
  
  
  METHODS
  High-fat diet (HFD) and streptozotocin-induced diabetic rats were randomly divided into model group, SalB subgroups (50, 100, and 200 mg/kg), and rosiglitazone group.
  
  
  RESULTS
  Compared with the model group, SalB (100 and 200 mg/kg) significantly decreased blood glucose (by 23.8 and 21.7%; p < 0.05 and p < 0.01) and insulin (by 31.3 and 26.6%; p < 0.05), and increased insulin sensitivity index (by 10.9 and 9.3%; p < 0.05). They also significantly decreased total cholesterol (by 24.9 and 27.9%; p < 0.01), low-density lipoprotein cholesterol (by 56.2 and 64.6%; p < 0.01), non-esterified fatty acids (by 32.1 and 37.9%; p < 0.01), hepatic glycogen (by 41.3 and 60.5%; p < 0.01), and muscle glycogen (by 33.2 and 38.6%; p < 0.05), and increased high-density lipoprotein cholesterol (by 50.0 and 61.4%; p < 0.05 and p < 0.01), which were originally altered by HFD and streptozotocin. In addition, SalB (200 mg/kg) markedly decreased triglyceride and malondialdehyde (by 31.5 and 29.0%; p < 0.05 and p < 0.01), and increased superoxide dismutase (by 56.6%; p < 0.01), which were originally altered by HFD and streptozotocin.
  
  
  CONCLUSIONS
  The results indicate that SalB can inhibit symptoms of diabetes mellitus in rats and these effects may partially be correlated with its insulin sensitivity, glycogen synthesis and antioxidant activities.
authors.affiliation: College of Pharmacy, Fujian University of Traditional Chinese Medicine , Fuzhou, Fujian , China .
authors.forename: Mingqing
authors.initials: M
authors.lastname: Huang
authors.forename: Peijian
authors.initials: P
authors.lastname: Wang
authors.forename: Shuyu
authors.initials: S
authors.lastname: Xu
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Kedan
authors.initials: K
authors.lastname: Chu
authors.forename: Jinjian
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza; D013311:Streptozocin / Q000633:toxicity*; D053630:Depsides
chemical_list: D001572:Benzofurans; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D013311:Streptozocin; C076944:salvianolic acid B; D053630:Depsides
keywords: Diabetes; glycogen synthesis; insulin resistance; oxidative stress