title: Synthesis, photophysical and antimicrobial activity of new water soluble ammonium quaternary benzanthrone in solution and in polylactide film.
abstract: The synthesis of a new cationic water soluble fluorescent 1-[(7-oxo-7H-benzo[de]anthracen-3-ylcarbamoyl)-methyl]-triethylammonium chloride (B) has been described. Due to the presence of the quaternary amino group, the compound is soluble in water. Its photophysical characteristics in aqueous solution and organic solvents with different polarity have been determined using absorption and fluorescence spectroscopy. The photostability of compound B has been investigated in aqueous media. The newly synthesized compound has been tested in vitro for its antimicrobial activity against eight bacterial and two yeasts cultures. The results obtained suggest that the newly synthesized compound is effective in treating the relevant pathogens and is suitable in designing new effective antimicrobial preparations. The incorporation of the compound into thin polylactic acid film and its release into water solution has been also investigated. It was demonstrated that the compound released from the polymer polylactic acid matrix exhibited a prolonged good antibacterial activity.
authors.affiliation: University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria.
authors.forename: Desislava
authors.initials: D
authors.lastname: Staneva
authors.affiliation: Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Vasileva-Tonkova
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Mohamad Saleh I
authors.initials: MS
authors.lastname: Makki
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Tariq Rashad
authors.initials: TR
authors.lastname: Sobahi
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Reda Mohamed
authors.initials: RM
authors.lastname: Abdеl-Rahman
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Asiri
authors.affiliation: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Sofia University "St. Kliment Ohridski", Faculty of Medicine, 1407 Sofia, Bulgaria. Electronic address: i.grabchev@chem.uni-sofia.bg.
authors.forename: Ivo
authors.initials: I
authors.lastname: Grabchev
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001551:Benz(a)Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011091:Polyesters / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: C000602446:1-((7-oxo-7H-benzo(de)anthracen-3-ylcarbamoyl)methyl)triethylammonium; D000890:Anti-Infective Agents; D001551:Benz(a)Anthracenes; D011083:Polycyclic Compounds; D011091:Polyesters; D000644:Quaternary Ammonium Compounds; D014867:Water; C033616:poly(lactide); C012768:benzanthrone