title: Multiple-Input Subject-Specific Modeling of Plasma Glucose Concentration for Feedforward Control.
abstract: The ability to accurately develop subject-specific, input causation models, for blood glucose concentration (BGC) for large input sets can have a significant impact on tightening control for insulin dependent diabetes. More specifically, for Type 1 diabetics (T1Ds), it can lead to an effective artificial pancreas (i.e., an automatic control system that delivers exogenous insulin) under extreme changes in critical disturbances. These disturbances include food consumption, activity variations, and physiological stress changes. Thus, this paper presents a free-living, outpatient, multiple-input, modeling method for BGC with strong causation attributes that is stable and guards against overfitting to provide an effective modeling approach for feedforward control (FFC). This approach is a Wiener block-oriented methodology, which has unique attributes for meeting critical requirements for effective, long-term, FFC.
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University , Ames, Iowa 50011, United States.
authors.forename: Kaylee
authors.initials: K
authors.lastname: Kotz
authors.affiliation: Department of Chemical and Biological Engineering, Illinois Institute of Technology , Chicago, Illinois 60616, United States.
authors.forename: Ali
authors.initials: A
authors.lastname: Cinar
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University , Ames, Iowa 50011, United States.
authors.forename: Yong
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University , Ames, Iowa 50011, United States.
authors.forename: Amy
authors.initials: A
authors.lastname: Roggendorf
authors.affiliation: Institute for Endocrine Discovery and Clinical Care, University of Chicago Medicine , Chicago, Illinois 60637, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Littlejohn
authors.affiliation: College of Nursing, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
authors.forename: Laurie
authors.initials: L
authors.lastname: Quinn
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University , Ames, Iowa 50011, United States ; Department of Statistics, Iowa State University , Ames, Iowa 50011, United States.
authors.forename: Derrick K
authors.initials: DK
authors.lastname: Rollins