title: [Determination of 2-hydroxyestrone /16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors].
abstract: The urinary ratio 2-hydroxyoestrone/16-hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined.
  
  
  OBJECTIVE
  To determine URME Mexican women and establish its relationship with risk factors for BC.
  
  
  METHODS
  Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMETTM and was related to risk factors for BC. Correlations and linear regressions were performed.
  
  
  RESULTS
  The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p.
authors.affiliation: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: Estela Ytelina
authors.initials: EY
authors.lastname: Godínez Martínez
authors.affiliation: Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: René
authors.initials: R
authors.lastname: Santillán Ballesteros
authors.affiliation: Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana Unidad Iztapalapa. Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. México.. eygodinez@hotmail.com.
authors.forename: Ana Elena
authors.initials: AE
authors.lastname: Lemus Bravo
authors.affiliation: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: Reyna
authors.initials: R
authors.lastname: Sámano
authors.affiliation: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: Maricruz
authors.initials: M
authors.lastname: Tolentino Dolores
authors.affiliation: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: Ana Lilia
authors.initials: AL
authors.lastname: Rodríguez Ventura
authors.affiliation: Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología.. eygodinez@hotmail.com.
authors.forename: Ana Rosa
authors.initials: AR
authors.lastname: Juárez González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D006894:Hydroxyestrones; C026702:16-hydroxyestrone; C024980:2-hydroxyestrone