title: Oxidative asymmetric umpolung alkylation of Evans' β-ketoimides using dialkylzinc nucleophiles.
abstract: Umpolung alkylation of Evans' auxiliary substituted β-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%. The reaction itself proceeds with diastereoselectivities between 3 : 1 and 18 : 1. Dialkylzinc serves as the nucleophile and umpolung of the β-keto-imide enolate is achieved by the action of Koser's reagent.
authors.affiliation: Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, 3200008 Haifa, Israel. szpilman@tx.technion.ac.il.
authors.forename: Tom A
authors.initials: TA
authors.lastname: Targel
authors.forename: Jayprakash N
authors.initials: JN
authors.lastname: Kumar
authors.forename: O Svetlana
authors.initials: OS
authors.lastname: Shneider
authors.forename: Sukanta
authors.initials: S
authors.lastname: Bar
authors.forename: Natalia
authors.initials: N
authors.lastname: Fridman
authors.forename: Shimon
authors.initials: S
authors.lastname: Maximenko
authors.forename: Alex M
authors.initials: AM
authors.lastname: Szpilman