title: [Protein-losing enteropathy].
abstract: Protein-losing enteropathy is a rare syndrome of gastrointestinal protein loss. The primary causes can be classified into lymphatic leakage due to increased interstitial pressure and increased leakage of protein-rich fluids due to erosive or non-erosive gastrointestinal disorders. The diagnosis of protein-losing enteropathy should be considered in patients with chronic diarrhea and peripheral oedema. The diagnosis of protein-losing enteropathy is most commonly based on the determination of fecal alpha-1 antitrypsin clearance. Most protein-losing enteropathy cases are the result of either lymphatic obstruction or a variety of gastrointestinal disorders and cardiac diseases, while primary intestinal lymphangiectasia (Waldmann's disease) is less common. Treatment of protein-losing enteropathy targets the underlying disease but also includes dietary modification, such as high-protein and low-fat diet along with medium-chain triglyceride supplementation.
authors.affiliation: Service d'hépato-gastroentérologie, hôpital Henri-Mondor, université Paris Est Créteil, AP-HP, 51, boulevard du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address: aurelien.amiot@hmn.aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Amiot
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D011504:Protein-Losing Enteropathies / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy
keywords: Alpha-1 antitrypsin; Alpha-1 antitrypsine; Fuite lymphatique; Gastro-entéropathie exsudative; Hypoalbuminemia; Hypoalbuminémie; Lymphatic leakage; Maladie de Waldmann; Protein-losing enteropathy; Waldmann's disease; Œdème