title: Fruit extract from a Sechium edule hybrid induce apoptosis in leukaemic cell lines but not in normal cells.
abstract: The antiproliferative potential of a crude extract from the chayote hybrid H-837-07-GISeM® and its potential for apoptosis induction were assessed in leukaemic cell lines and normal mouse bone marrow mononuclear cells (BM-MNCs). The extract strongly inhibited the proliferation of the P388, J774, and WEHI-3 cell lines (with an IC50 below 1.3 μg·mL(-1)), reduced cell viability, and induced apoptotic body production, phosphatidylserine translocation, and DNA fragmentation. However, the extract had no effect on BM-MNCs. We postulate that these properties make the extract a good candidate for an anti-tumour agent for clinical use.
authors.affiliation: a Postgraduate College , Texcoco , Mexico ; Mexican Interdisciplinary Research Group on Sechium , Texcoco , Mexico Estate , Mexico ; and School of Higher Education of Zaragoza, National Autonomous University of Mexico , Mexico City , Mexico.
authors.forename: Itzen
authors.initials: I
authors.lastname: Aguiñiga-Sánchez
authors.forename: Marcos
authors.initials: M
authors.lastname: Soto-Hernández
authors.forename: Jorge
authors.initials: J
authors.lastname: Cadena-Iñiguez
authors.forename: Lucero del Mar
authors.initials: Ldel M
authors.lastname: Ruíz-Posadas
authors.forename: Jorge David
authors.initials: JD
authors.lastname: Cadena-Zamudio
authors.forename: Ana Karen
authors.initials: AK
authors.lastname: González-Ugarte
authors.forename: Benny Weiss
authors.initials: BW
authors.lastname: Steider
authors.forename: Edelmiro
authors.initials: E
authors.lastname: Santiago-Osorio
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002678:Chimera; D019662:Cucurbitaceae / Q000737:chemistry; D053938:DNA Fragmentation; D005260:Female; D005638:Fruit; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D009000:Monocytes / Q000187:drug effects; D049294:Phospholipid Transfer Proteins / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D049294:Phospholipid Transfer Proteins; D010936:Plant Extracts