title: Brain-derived neurotrophic factor expression in dorsal root ganglion neurons in response to reanastomosis of the distal stoma after nerve grafting.
abstract: Studies have shown that retreatment of the distal stoma after nerve grafting can stimulate nerve regeneration. The present study attempted to verify the effects of reanastomosis of the distal stoma, after nerve grafting, on nerve regeneration by assessing brain-derived neurotrophic factor expression in 2-month-old rats. Results showed that brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after autologous nerve grafting post sciatic nerve injury, peaked at 14 days, decreased at 28 days, and reached similar levels to the sham-surgery group at 56 days. Brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia began to increase 3 days after reanastomosis of the distal stoma, 59 days after autologous nerve grafting post sciatic nerve injury, significantly increased at 63 days, peaked at 70 days, and gradually decreased thereafter, but remained higher compared with the sham-surgery group up to 112 days. The results of this study indicate that reanastomosis of the distal stoma after orthotopic nerve grafting stimulated brain-derived neurotrophic factor expression in L2-4 dorsal root ganglia.
authors.affiliation: Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Nephrology, China Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Xu
authors.affiliation: Norman Bethune Medical College, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Hanjiao
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Hand Surgery, China Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Shusen
authors.initials: S
authors.lastname: Cui
keywords: brain-derived neurotrophic factor; distal stoma; dorsal root ganglion; neural regeneration; orthotopic nerve grafting; peripheral nerve injury; reanastomosis; sciatic nerve