title: [New insights in adrenal Cushing syndrome].
abstract: The development of molecular biology tools has allowed major advances in the genetic determinism and the pathophysiology of pheochromocytomas and Conn's adenomas. However, the molecular pathophysiology of ACTH-independent Cushing's Syndrome was mostly unknown until recently. In 2014, major new insights concerning the physiopathology of ACTH-independent macronodular adrenal hyperplasias (AIMAH) and the cortisol-secreting adenomas have been published. Elsewhere, the cardiovascular consequences of the subclinical hypercortisolism due to adrenal incidentalomas, was described only in some cross-sectional studies. The natural history of these lesions has been documented in two large follow-up studies. These new data presented during the Endocrine Congress are summarized herein.
authors.affiliation: Service d'endocrinologie, diabétologie et maladies métaboliques, Faculté de médecine Bordeaux-Victor-Ségalen, CHU de Bordeaux, Hôpital Haut-Lévêque, 33600 Pessac, France. Electronic address: magalie.haissaguerre@hotmail.fr.
authors.forename: M
authors.initials: M
authors.lastname: Haissaguerre
authors.affiliation: Service d'endocrinologie, diabétologie et maladies métaboliques, Faculté de médecine Bordeaux-Victor-Ségalen, CHU de Bordeaux, Hôpital Haut-Lévêque, 33600 Pessac, France.
authors.forename: A
authors.initials: A
authors.lastname: Tabarin
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism; D000310:Adrenal Gland Neoplasms; D000311:Adrenal Glands / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone; D000328:Adult; D051186:Armadillo Domain Proteins; D003480:Cushing Syndrome / Q000235:genetics / Q000503:physiopathology; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits / Q000235:genetics; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C000590373:ARMC5 protein, human; D051186:Armadillo Domain Proteins; D025521:Tumor Suppressor Proteins; D000324:Adrenocorticotropic Hormone; D054751:Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; C517757:PRKACA protein, human; D006854:Hydrocortisone
keywords: ACTH-independent Cushing's syndrome; ARMC5 mutations; Adénomes cortisoliques infracliniques; Bilateral Macronodular Adrenal Hyperplasia (AIMAH); Hyperplasie macronodulaire bilatérale des surrénales; Mutations ARMC5; Mutations PRKACA; PRKACA mutations; Subclinical Cortisol-Secreting Adenomas; Syndrome de Cushing ACTH-indépendant