title: Isolation and assessment of the in vitro anti-tumor activity of smenothiazole A and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea.
abstract: The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. germana.esposito@unina.it.
authors.forename: Germana
authors.initials: G
authors.lastname: Esposito
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. roberta.teta@unina.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Teta
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy. r.miceli@istitutotumori.na.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Miceli
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy. luca.ceccarelli@virgilio.it.
authors.forename: Luca S
authors.initials: LS
authors.lastname: Ceccarelli
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. gerardo.dellasala@unina.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Della Sala
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy. r.camerlingo@istitutotumori.na.it.
authors.forename: Rosa
authors.initials: R
authors.lastname: Camerlingo
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy. e.irollo@istitutotumori.na.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Irollo
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. alfonso.mangoni@unina.it.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mangoni
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", Via M. Semmola, 80131 Napoli, Italy. g.pirozzi@istitutotumori.na.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pirozzi
authors.affiliation: The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. valeria.costantino@unina.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Costantino
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D061986:MCF-7 Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013844:Thiazoles; C000601285:smenothiazole A; C000601286:smenothiazole B; D014633:Valine