title: Combined inhalation and oral supplementation of Vitamin A and Vitamin D: a possible prevention and therapy for tuberculosis.
abstract: Tuberculosis is continuing as a problem of mankind. With evolution, MDR and XDR forms of tuberculosis have emerged from drug sensitive strain. MDR and XDR strains are resistant to most of the antibiotics, making the management more difficult. BCG vaccine is not providing complete protection against tuberculosis. Therefore new infections are spreading at a tremendous rate. At the present moment there is experimental evidence to believe that Vitamin A and Vitamin D has anti-mycobacterial property. It is in this context, we have hypothesized a host based approach using the above vitamins that can cause possible prevention and cure of tuberculosis with minimal chance of resistance or toxicity.
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India.
authors.forename: Kirtimaan
authors.initials: K
authors.lastname: Syal
authors.affiliation: Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India.
authors.forename: Surajit
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala 133207, India.
authors.forename: Rajasri
authors.initials: R
authors.lastname: Bhattacharyya
authors.affiliation: Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India. Electronic address: dibyajyoti5200@yahoo.co.in.
authors.forename: Dibyajyoti
authors.initials: D
authors.lastname: Banerjee
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008954:Models, Biological; D014376:Tuberculosis / Q000517:prevention & control*; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000904:Antibiotics, Antitubercular; D004338:Drug Combinations; D014801:Vitamin A; D014807:Vitamin D