title: Steroid promiscuity: Diversity of enzyme action. Preface.
abstract: This Special Issue on the topic of Steroid and Sterol Signaling: Promiscuity and Diversity, dwells on the growing realization that the 'one ligand, one binding site' and 'one enzyme, one reaction' concepts are out of date. Focusing on cytochromes P450 (CYP), hydroxysteroid dehydrogenases (HSDs), and related enzymes, the Special Issue highlights that a single enzyme can bind to diverse substrates, and in different conformations, and can catalyze multiple different conversions (and in different directions), thereby, generating an unexpectedly wide spectrum of ligands that can have subtly different biological actions. This article is part of a Special Issue entitled 'Steroid/Sterol Signaling' .
authors.affiliation: Pieta Research, Edinburgh, UK; Pushchino State University and Institute of Bioorganic Chemistry, Moscow Region, Russian Federation. Electronic address: rlathe@pieta-research.org.
authors.forename: Richard
authors.initials: R
authors.lastname: Lathe
authors.affiliation: Skolkovo Institute of Science and Technology, Moscow Region, Russian Federation.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kotelevtsev
authors.affiliation: MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. Electronic address: j.i.mason@ed.ac.uk.
authors.forename: J Ian
authors.initials: JI
authors.lastname: Mason
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008024:Ligands; D013256:Steroids / Q000378:metabolism*; D002785:Sterol O-Acyltransferase / Q000378:metabolism
chemical_list: D008024:Ligands; D013256:Steroids; D003577:Cytochrome P-450 Enzyme System; D006913:Hydroxysteroid Dehydrogenases; D002785:Sterol O-Acyltransferase
keywords: Promiscuity; Steroid