title: Bacteriophage-derived vectors for targeted cancer gene therapy.
abstract: Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration.
authors.affiliation: Institute of Clinical and Biomedical Science, University of Exeter Medical School, Exeter, Devon EX1 2LU, UK. z.pranjol@exeter.ac.uk.
authors.forename: Md Zahidul Islam
authors.initials: MZ
authors.lastname: Pranjol
authors.affiliation: Phage Therapy Group, Department of Medicine, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. a.hajitou@imperial.ac.uk.
authors.forename: Amin
authors.initials: A
authors.lastname: Hajitou
mesh_terms: D001435:Bacteriophages / Q000235:genetics*; D001691:Biological Therapy / Q000379:methods*; D035843:Biomedical Research / Q000639:trends; D018390:Gene Targeting / Q000379:methods*; D052138:Genes, Neoplasm; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans