title: Depression and vasomotor symptoms in young breast cancer survivors: the mediating role of sleep disturbance.
abstract: Depression, sleep disturbance, and vasomotor symptoms are common in breast cancer survivors (BCS), especially in younger women diagnosed before menopause. Risk factors and mechanisms for depression in this population are relatively unexplored. In 163 young BCS, vasomotor symptoms were significantly associated with higher depressive symptoms (β = 0.26, p = 0.001) and 64 % of the total effect was mediated through sleep disturbance (beta for specific indirect effect = 1.296, 95 % CI 0.591-2.212). Treatments reducing vasomotor symptoms might alleviate sleep disturbance and depression in this population.
authors.affiliation: Department of Psychology, University of California Los Angeles (UCLA), 1285, Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA, eaccortt@gmail.com.
authors.forename: Eynav E
authors.initials: EE
authors.lastname: Accortt
authors.forename: Julienne E
authors.initials: JE
authors.lastname: Bower
authors.forename: Annette L
authors.initials: AL
authors.lastname: Stanton
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Ganz
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000150:complications / Q000523:psychology*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006306:Health Surveys; D019584:Hot Flashes / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D011788:Quality of Life; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology* / Q000706:statistics & numerical data