title: Designing a deep brain stimulator to suppress pathological neuronal synchrony.
abstract: Some of neuropathologies are believed to be related to abnormal synchronization of neurons. In the line of therapy, designing effective deep brain stimulators to suppress the pathological synchrony among neuronal ensembles is a challenge of high clinical relevance. The stimulation should be able to disrupt the synchrony in the presence of latencies due to imperfect knowledge about parameters of a neuronal ensemble and stimulation impacts on the ensemble. We propose an adaptive desynchronizing deep brain stimulator capable of dealing with these uncertainties. We analyze the collective behavior of the stimulated neuronal ensemble and show that, using the designed stimulator, the resulting asynchronous state is stable. Simulation results reveal the efficiency of the proposed technique.
authors.affiliation: Advanced Control Systems Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran; Department of Systems Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. Electronic address: montaseri@theoretical-biology.de.
authors.forename: Ghazal
authors.initials: G
authors.lastname: Montaseri
authors.affiliation: Advanced Control Systems Laboratory, Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran. Electronic address: yazdan@ut.ac.ir.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Yazdanpanah
authors.affiliation: Human Motor Control and Computational Neuroscience Laboratory, Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran. Electronic address: fbahrami@ut.ac.ir.
authors.forename: Fariba
authors.initials: F
authors.lastname: Bahrami
mesh_terms: D001921:Brain / Q000502:physiology*; D058256:Brain Waves; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008959:Models, Neurological
keywords: Adaptive structure; Desynchronizing stimulation; Hindmarsh–Rose neural networks