title: Commentary: the effects of psychological stress on microglial cells in the brain.
abstract: Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, China. ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.forename: Gonglin
authors.initials: G
authors.lastname: Hou
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology*; D049109:Cell Proliferation / Q000502:physiology; D002908:Chronic Disease; D005938:Glucocorticoids / Q000378:metabolism; D017628:Microglia / Q000473:pathology* / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D013315:Stress, Psychological / Q000276:immunology* / Q000473:pathology*
chemical_list: D005938:Glucocorticoids; D009638:Norepinephrine