title: [The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus].
abstract: Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.
authors.affiliation: Szent István Egyetem Állatorvos-tudományi Kar Budapest Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi utca 46. 1088.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Herold
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Patológiai és Kísérleti Rákkutató Intézet Budapest.
authors.forename: Péter
authors.initials: P
authors.lastname: Nagy
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Budapest MTA-SE "Lendület" Örökletes Endokrin Daganatok Kutatócsoport Budapest.
authors.forename: Attila
authors.initials: A
authors.lastname: Patócs
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi utca 46. 1088.
authors.forename: Anikó
authors.initials: A
authors.lastname: Somogyi
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018278:Carcinoma, Neuroendocrine / Q000097:blood / Q000175:diagnosis; D053379:Chromogranin A / Q000096:biosynthesis / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D004067:Digestive System Neoplasms / Q000097:blood / Q000175:diagnosis; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology*; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D001324:Autoantigens; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D009363:Neoplasm Proteins; C074381:chromogranin A-derived peptide, WE-14
keywords: WE-14; chromogranin-A; diabetes mellitus; kromogranin-A; tumormarker; tumour marker