title: Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics.
abstract: While advances in genome sequencing technology make population-scale genomics a possibility, current approaches for analysis of these data rely upon parallelization strategies that have limited scalability, complex implementation and lack reproducibility. Churchill, a balanced regional parallelization strategy, overcomes these challenges, fully automating the multiple steps required to go from raw sequencing reads to variant discovery. Through implementation of novel deterministic parallelization techniques, Churchill allows computationally efficient analysis of a high-depth whole genome sample in less than two hours. The method is highly scalable, enabling full analysis of the 1000 Genomes raw sequence dataset in a week using cloud resources. http://churchill.nchri.org/.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Kelly
authors.forename: James R
authors.initials: JR
authors.lastname: Fitch
authors.forename: Yangqiu
authors.initials: Y
authors.lastname: Hu
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Corsmeier
authors.forename: Huachun
authors.initials: H
authors.lastname: Zhong
authors.forename: Amy N
authors.initials: AN
authors.lastname: Wetzel
authors.forename: Russell D
authors.initials: RD
authors.lastname: Nordquist
authors.forename: David L
authors.initials: DL
authors.lastname: Newsom
authors.affiliation: Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus 43205, OH, USA.|Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: White
mesh_terms: D000067917:Cloud Computing; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D012984:Software; D013997:Time Factors