title: Necrotising pneumonia and bronchiectasis in a previously healthy 30-year-old man.
abstract: We present a case of a previously healthy 30-year-old man who presented with a necrotising pneumonia and bronchiectasis. His infectious workup revealed a Staphylococcus aureus pneumonia. Since bronchiectasis and necrotising pneumonia are unusual findings in an otherwise healthy person, further investigation was pursued. His workup revealed non-classic cystic fibrosis (CF) and allergic bronchopulmonary aspergillosis (ABPA). This case discusses the differential diagnosis of bronchiectasis, the diagnosis and treatment of ABPA, and the role of CF mutations in the pathogenesis of ABPA.
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Blauvelt
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Castellanos
authors.affiliation: Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Theodore A
authors.initials: TA
authors.lastname: Stern
authors.affiliation: Massachusetts General Hospital, Boston, Massachusetts, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Puig
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis* / Q000188:drug therapy; D001987:Bronchiectasis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003550:Cystic Fibrosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents