title: High respiratory virus oropharyngeal carriage rate during Kingella kingae osteoarticular infections in children.
abstract: OBJECTIVE
  Kingella kingae osteoarticular (KKO) infections are frequently associated with upper respiratory tract infections. However, no comparative studies detecting respiratory viruses had ever been performed between KKO and non-KKO (NKO).
  
  
  METHODS
  Eighteen viruses were searched by FilmArray(®) Respiratory Panel (BioFire Diagnostics, UT, USA) in the oropharynx of 6-to-48-month-children admitted for KKO and NKO in 2013.
  
  
  RESULTS
  At least one virus was detected in the oropharynx of 19/21 (90.5%) KKO and 3/8 (37.5%) NKO cases (p = 0.008). In KKO group, human rhinovirus was predominant (12/21; 57.1%), especially during winter (7/11; 63.6%) despite its low concomitant circulation (<10%). Human rhinovirus was found in 2/8 (25%) in NKO group.
  
  
  CONCLUSIONS
  Higher prevalence of respiratory virus in oropharynx was observed in KKO than NKO, strengthening their putative role in KKO pathophysiology.
authors.affiliation: INSERM, IAME, UMR 1137, F-75018 Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Basmaci
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: Brice
authors.initials: B
authors.lastname: Ilharreborde
authors.forename: Catherine
authors.initials: C
authors.lastname: Doit
authors.forename: Mathie
authors.initials: M
authors.lastname: Lorrot
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Kahil
authors.forename: Benoît
authors.initials: B
authors.lastname: Visseaux
authors.forename: Nadhira
authors.initials: N
authors.lastname: Houhou
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
mesh_terms: D001170:Arthritis, Infectious / Q000382:microbiology*; D001850:Bone Diseases, Infectious / Q000382:microbiology*; D002353:Carrier State / Q000453:epidemiology; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D017882:Kingella kingae / Q000302:isolation & purification*; D056265:Microbial Interactions; D016870:Neisseriaceae Infections / Q000382:microbiology*; D009960:Oropharynx / Q000382:microbiology / Q000821:virology*; D010850:Picornaviridae Infections / Q000453:epidemiology*; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D012229:Rhinovirus / Q000302:isolation & purification*
keywords: Kingella kingae; PCR; human rhinovirus; osteoarticular infection; respiratory virus; upper respiratory tract infection