title: Mesolimbic dopaminergic dysfunction in Parkinson's disease depression: evidence from a 123I-FP-CIT SPECT investigation.
abstract: We investigated the striatal and extrastriatal DAT availability (SPM8) by [(123)I]FP-CIT-SPECT in 15 PD patients with depression and 35 PD patients without depression. A cluster with significant (p < 0.05) lower tracer binding in PD with depression was found in left cingulate cortex, persistent after correction for age, disease severity and duration, and inversely correlated with depression scores (r -0.336, p < 0.05). Our data indicate a significant association between PD depression and cingulate dopaminergic denervation supporting the dopaminergic hypothesis of PD depression.
authors.affiliation: Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67-56126, Pisa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Frosini
authors.forename: E
authors.initials: E
authors.lastname: Unti
authors.forename: F
authors.initials: F
authors.lastname: Guidoccio
authors.forename: C
authors.initials: C
authors.lastname: Del Gamba
authors.forename: G
authors.initials: G
authors.lastname: Puccini
authors.forename: D
authors.initials: D
authors.lastname: Volterrani
authors.forename: U
authors.initials: U
authors.lastname: Bonuccelli
authors.forename: R
authors.initials: R
authors.lastname: Ceravolo
mesh_terms: D000368:Aged; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism*; D003866:Depressive Disorder / Q000150:complications / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology; D011699:Putamen / Q000000981:diagnostic imaging / Q000378:metabolism*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine