title: [Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging].
abstract: OBJECTIVE
  To explore the neural mechanisms of attention-deficit hyperactivity disorder (ADHD) through analyzing the intensity of functional connection between bilateral hemispheres of children with ADHD by resting-state functional magnetic resonance imaging (rs-fMRI).
  
  
  METHODS
  The approach of voxel-mirrored homotopic connectivity (VMHC) was employed to analyze 31 school-age and 31 ADHD children by rs-fMRI scans.
  
  
  RESULTS
  Positively activated brain regions were visualized when comparing ADHD and normal children, suggesting that ADHD children's VMHC scores were higher in bilateral frontal lobe (t = 5.81), bilateral occipital lobe (t = 5.82) and bilateral cerebellar posterior lobe (t = 6.17). Statistically significant differences existed between two groups (FDR correction, Q<0.01).
  
  
  CONCLUSIONS
  The increased intensity of functional connection between bilateral prefrontal lobes in children with ADHD reflects attention disorder and leads to a decline of working memory . The strengthening of bilateral occipital lobes slows down memory process. And the increased intensity of cerebellar connections may damage neural circuits and aggravate ADHD symptoms.
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Kaihua
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Qinfen
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China. Email: 50191257@qq.com.
authors.forename: Aibin
authors.initials: A
authors.lastname: Zheng
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity; D001921:Brain; D001931:Brain Mapping; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term