title: Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility.
abstract: Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. The rs16892766 (8q23.3) polymorphism was first identified to be significantly associated with CRC in European ancestry. The following studies investigated this association in Chinese, Japanese, Romanian, Swedish, African American, European American, and Croatian populations. These studies reported consistent and inconsistent results. Here, we reevaluated this association using the relatively large-scale samples from 13 studies (N = 59737, 26237 cases and 33500 controls) using a meta-analysis by searching the PubMed, Google Scholar and CRCgene databases. We observed no significant heterogeneity among the included studies. Our results showed significant association between rs16892766 polymorphism and CRC (P = 1.33E-35, OR = 1.23, 95% CI 1.20-1.27). Collectively, our analysis further supports previous findings that the rs16892766 polymorphism is significantly associated with CRC susceptibility. We believe that our findings will be very useful for future genetic studies on CRC.
authors.affiliation: College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
authors.affiliation: 1] Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China [2] Department of Oncology, The First Hospital of Harbin, Harbin, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First Hospital of Harbin, Harbin, China.
authors.forename: Baoku
authors.initials: B
authors.lastname: Quan
authors.affiliation: Department of Gastroenterology, The First Hospital of Harbin, Harbin, China.
authors.forename: Xingsi
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Gastroenterology, General Hospital of Heilongjiang Land Reclamation Bureau, Harbin, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.affiliation: Department of Statistics, Rice University, Houston, TX, USA.
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Yongshuai
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yanqiao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China.
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias