title: Gelatin microcapsules for enhanced microwave tumor hyperthermia.
abstract: Local and rapid heating by microwave (MW) irradiation is important in the clinical treatment of tumors using hyperthermia. We report here a new thermo-seed technique for the highly efficient MW irradiation ablation of tumors in vivo based on gelatin microcapsules. We achieved 100% tumor elimination in a mouse model at an ultralow power of 1.8 W without any side-effects. The results of MTT assays, a hemolysis test and the histological staining of organs indicated that the gelatin microcapsules showed excellent compatibility with the physiological environment. A possible mechanism is proposed for MW hyperthermia using gelatin microcapsules. We also used gelatin microcapsules capped with CdTe quantum dots for in vivo optical imaging. Our study suggests that these microcapsules may have potential applications in imaging-guided cancer treatment.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. mengxw@mail.ipc.ac.cn.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Du
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.forename: Jian
authors.initials: J
authors.lastname: Tie
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D019187:Cadmium Compounds / Q000737:chemistry; D002470:Cell Survival; D003102:Colloids / Q000737:chemistry; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D006461:Hemolysis; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000628:therapy*; D055095:Optics and Photonics; D045663:Quantum Dots; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013691:Tellurium / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D019187:Cadmium Compounds; D003102:Colloids; D005456:Fluorescent Dyes; D005780:Gelatin; D007770:L-Lactate Dehydrogenase; D013691:Tellurium; C028337:cadmium telluride