title: [Regularity of drugs compatibility of anti-hepatoma traditional Chinese medicine ancient prescriptions and risk evaluation of anti-hepatoma new drug research and development].
abstract: Traditional Chinese ancient prescriptions have been used for treatment of liver cancer for a long history and the scientific and rational compatibility is a great wealth for modern research and development (R&D) of new drugs. The research and development of new drugs are often accompanied with a large investment, a long cycle and a high risk, especially for the anti-tumor drugs R&D which are facing more risks and lower successful rate. In this research, the regularity of compatibility of drugs was analyzed from 124 anti-hepatoma ancient prescriptions by computer program. The results can offer help to the R&D of anti-hepatoma new drugs and reduce the risk of drug screening. In addition, we surveyed 22 companies in this field from six provinces such as Beijing, Shanghai, Tianjin and so on and obtained 240 risk assessment questionaires. Then we used qualitative analysis method to interpret the greatest impacts for the risks in the process of R&D, production and sales of anti-hepatoma new drugs. The study provides a basis for anti-liver cancer drugs R&D researchers, who can take effective measures to reduce the R&D risks and improve successful rate.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hong-Fa
authors.initials: HF
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Man
authors.forename: Shu-Yong
authors.initials: SY
authors.lastname: Si
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Gao
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000266:history; D002681:China; D055808:Drug Discovery / Q000266:history; D004344:Drug Incompatibility; D011307:Drug Prescriptions / Q000266:history; D004365:Drugs, Chinese Herbal / Q000266:history / Q000627:therapeutic use*; D049690:History, Ancient; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000266:history; D012106:Research / Q000266:history
chemical_list: D004365:Drugs, Chinese Herbal