title: Arthpyrones A-C, pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3.
abstract: Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A-C (1-3), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Their structures were elucidated on the basis of spectroscopic analysis, CD spectra, quantum chemical calculation, and X-ray single-crystal diffraction analysis. Compounds 1 and 2 possessed a 2-pyridone core featured with a decalin moiety linked via a carboxide bridge bearing a novel oxabicyclo[3.3.1]nonane ring system rarely discovered in nature. A possible biosynthetic pathway for them was proposed.
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Qin
authors.forename: Xiuping
authors.initials: X
authors.lastname: Lin
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Shengrong
authors.initials: S
authors.lastname: Liao
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Zhengchao
authors.initials: Z
authors.lastname: Tu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D061986:MCF-7 Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology*; D011725:Pyridines; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011725:Pyridines; D011728:Pyridones; C000596570:arthpyrone A; C000596571:arthpyrone B; C000596572:arthpyrone C; C039659:2,4-dihydroxypyridine; C017679:2-hydroxypyridine