title: [Treatment of spasticity in children with cerebral palsy with botulinum toxin A].
abstract: Over the latest 30 years there has been an increasing use of botulinum toxin A injections in the lower limbs in children with cerebral palsy. However, the conclusions regarding effect of treatment in both randomized controlled and non-controlled trials have been inconclusive. One explanation may be that children with cerebral palsy do not always exhibit pure spasticity and/or dystonia of the affected muscles. Furthermore, the dose, injection volume and injection technique may vary from study to study. The evidence for the effect is so small that careful consideration on whether to continue this treatment regimen or not is needed.
authors.affiliation: Ortopædkirurgisk Afdeling, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre. jesper.bencke@regionh.dk.
authors.forename: Ea Serie Lundegaard
authors.initials: ES
authors.lastname: Madsen
authors.forename: Stig
authors.initials: S
authors.lastname: Sonne-Holm
authors.forename: Christian
authors.initials: C
authors.lastname: Wong
authors.forename: Derek
authors.initials: D
authors.lastname: Curtis
authors.forename: Jesper
authors.initials: J
authors.lastname: Bencke
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002648:Child; D003718:Denmark; D019317:Evidence-Based Medicine; D006801:Humans; D007273:Injections, Intramuscular; D007866:Leg; D009128:Muscle Spasticity / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A