title: Advanced research on vasculogenic mimicry in cancer.
abstract: Vasculogenic mimicry (VM) is a brand-new tumour vascular paradigm independent of angiogenesis that describes the specific capacity of aggressive cancer cells to form vessel-like networks that provide adequate blood supply for tumour growth. A variety of molecule mechanisms and signal pathways participate in VM induction. Additionally, cancer stem cell and epithelial-mesenchymal transitions are also shown to be implicated in VM formation. As a unique perfusion way, VM is associated with tumour invasion, metastasis and poor cancer patient prognosis. Due to VM's important effects on tumour progression, more VM-related strategies are being utilized for anticancer treatment. Here, with regard to the above aspects, we make a review of advanced research on VM in cancer.
authors.affiliation: Department of Oncology, Shandong University School of Medicine, Jinan, Shandong Pro, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Qiao
authors.forename: Ning
authors.initials: N
authors.lastname: Liang
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.forename: Fengjun
authors.initials: F
authors.lastname: Liu
authors.forename: Deguo
authors.initials: D
authors.lastname: Xu
authors.forename: Xinshuang
authors.initials: X
authors.lastname: Yu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
keywords: cancer stem cell; high aggressive tumour; molecular regulation; prognosis; tumour-target therapy; vasculogenic mimicry