title: Placental mesenchymal dysplasia without fetal development in a twin gestation: a case report and review of the spectrum of androgenetic biparental mosaicism.
abstract: We report a dichorionic twin gestation with diffuse placental mesenchymal dysplasia (PMD) and androgenetic biparental mosaicism (ABM) involving one twin's placenta with complete absence of fetal development for that twin. To our knowledge, this is the 1st reported case of PMD without fetal development. We discuss the gross, histologic, and genetic hallmarks of PMD and the spectrum of variability depending on degree and distribution of ABM.
authors.affiliation: 1 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Linn
authors.forename: Lucy
authors.initials: L
authors.lastname: Minturn
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Yee
authors.forename: Kruti
authors.initials: K
authors.lastname: Maniar
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Michael K
authors.initials: MK
authors.lastname: Fritsch
authors.forename: Papreddy
authors.initials: P
authors.lastname: Kashireddy
authors.forename: Raj
authors.initials: R
authors.lastname: Kapur
authors.forename: Linda M
authors.initials: LM
authors.lastname: Ernst
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008648:Mesoderm / Q000002:abnormalities*; D009030:Mosaicism; D010641:Phenotype; D010920:Placenta / Q000002:abnormalities*; D010922:Placenta Diseases / Q000175:diagnosis / Q000235:genetics*; D011237:Predictive Value of Tests; D011247:Pregnancy; D059285:Pregnancy, Twin; D012307:Risk Factors; D014429:Twins, Dizygotic / Q000235:genetics*; D016216:Ultrasonography, Prenatal
keywords: androgenetic biparental mosaicism; hydatidiform mole; placental mesenchymal dysplasia