title: Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments: A Case-Controlled Study.
abstract: The same aggressive treatments that have led to a reduction in the breast cancer may also have adverse effects on cardiac autonomic balance. The objective of this study was to compare heart rate variability (HRV) between breast cancer survivors in the first year posttreatment and healthy women, controlling for known confounders. This descriptive case-controlled study included 22 breast cancer survivors and 22 healthy age- and sex-matched controls. Short-term HRV was measured using an accepted methodology to assess the cardiac autonomic balance. One-way analysis of covariance results revealed that heart rate was significantly higher (F = 15.86, p < .001) and the standard deviation of normal-to-normal (NN) interval (F = 19.93, p = .001), square root of mean squared differences of successive NN intervals (F = 18.72, p = .001), HRV index (F = 5.44, p = .025), and high-frequency (F = 5.77, p = .03) values were significantly lower in the breast cancer survivors than in the matched controls. The principal finding of the presence of a cardiovascular imbalance in breast cancer survivors in comparison to healthy age-matched controls suggests that HRV study could be a clinically useful tool to detect cardiovascular disease in early-stage breast cancer survivors.
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Caro-Morán
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain Sport and Health University Research Institute, University of Granada, Granada, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Fernández-Lao
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain Sport and Health University Research Institute, University of Granada, Granada, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Galiano-Castillo
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain Sport and Health University Research Institute, University of Granada, Granada, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Cantarero-Villanueva
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain Sport and Health University Research Institute, University of Granada, Granada, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Arroyo-Morales
authors.affiliation: Instituto Biosanitario Granada, Faculty of Health Sciences, University of Granada, Granada, Spain Sport and Health University Research Institute, University of Granada, Granada, Spain Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain cldiaz@ugr.es.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Díaz-Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy*; D016022:Case-Control Studies; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D013030:Spain; D017741:Survivors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents
keywords: autonomic nervous system; breast cancer survivors; heart rate variability