title: Solid-phase synthesis as a platform for the discovery of new ruthenium complexes for efficient release of photocaged ligands with visible light.
abstract: Ruthenium-based photocaging groups have important applications as biological tools and show great potential as therapeutics. A method was developed to rapidly synthesize, screen, and identify ruthenium-based caging groups that release nitriles upon irradiation with visible light. A diverse library of tetra- and pentadentate ligands was synthesized on polystyrene resin. Ruthenium complexes of the general formula [Ru(L)(MeCN)n](m+) (n = 1-3, m = 1-2) were generated from these ligands on solid phase and then cleaved from resin for photochemical analysis. Data indicate a wide range of spectral tuning and reactivity with visible light. Three complexes that showed strong absorbance in the visible range were synthesized by solution phase for comparison. Photochemical behavior of solution- and solid-phase complexes was in good agreement, confirming that the library approach is useful in identifying candidates with desired photoreactivity in short order, avoiding time-consuming chromatography and compound purification.
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Rajgopal
authors.initials: R
authors.lastname: Sharma
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Knoll
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ancona
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Martin
authors.forename: Claudia
authors.initials: C
authors.lastname: Turro
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Kodanko
mesh_terms: D008024:Ligands; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium