title: Therapeutic antibodies against CGRP or its receptor.
abstract: CGRP is an extensively studied neuropeptide that has been implicated in the pathophysiology of migraine. While a number of small molecule antagonists against the CGRP receptor have demonstrated that targeting this pathway is a valid and effective way of treating migraine, off-target hepatoxicity and formulation issues have hampered the development for regulatory approval of any therapeutic in this class. The development of monoclonal antibodies to CGRP or its receptor as therapeutic agents has allowed this pathway to be re-investigated. Herein we review why CGRP is an ideal target for the prevention of migraine and describe four monoclonal antibodies against either CGRP or its receptor that are in clinical development for the treatment of both episodic and chronic migraine. We describe what has been publically disclosed about their clinical trials and future clinical development plans.
authors.affiliation: Vice President, Migraine & Headache Clinical Development, Teva Pharmaceuticals, Frazer, PA.|Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Bigal
authors.affiliation: Director of Preclinical Research, Labrys Biologics, Inc, San Mateo, CA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Walter
authors.affiliation: Director-Emeritus, New England Center for Headache, Stamford, CT.|Clinical Professor of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Rapoport
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D015740:Calcitonin Gene-Related Peptide / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D055808:Drug Discovery; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D018015:Receptors, Calcitonin Gene-Related Peptide; D015740:Calcitonin Gene-Related Peptide
keywords: CGRP; chronic migraine; migraine; monoclonal antibodies