title: Statistical mechanics of viral entry.
abstract: Viruses that have lipid-membrane envelopes infect cells by fusing with the cell membrane to release viral genes. Membrane fusion is known to be hindered by high kinetic barriers associated with drastic structural rearrangements-yet viral infection, which occurs by fusion, proceeds on remarkably short time scales. Here, we present a quantitative framework that captures the principles behind the invasion strategy shared by all enveloped viruses. The key to this strategy-ligand-triggered conformational changes in the viral proteins that pull the membranes together-is treated as a set of concurrent, bias field-induced activated rate processes. The framework results in analytical solutions for experimentally measurable characteristics of virus-cell fusion and enables us to express the efficiency of the viral strategy in quantitative terms. The predictive value of the theory is validated through simulations and illustrated through recent experimental data on influenza virus infection.
authors.affiliation: Department of Physics, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Physics, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Olga K
authors.initials: OK
authors.lastname: Dudko
mesh_terms: D003198:Computer Simulation; D008561:Membrane Fusion / Q000502:physiology*; D008954:Models, Biological; D009975:Orthomyxoviridae / Q000502:physiology; D011487:Protein Conformation; D014759:Viral Envelope Proteins / Q000502:physiology*; D053586:Virus Internalization
chemical_list: D014759:Viral Envelope Proteins