title: (E)-α,β-unsaturated amides from tertiary amines, olefins and CO via Pd/Cu-catalyzed aerobic oxidative N-dealkylation.
abstract: A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed. Tertiary amines are utilized as a "reservoir" of "active" secondary amines in this transformation, which inhibits the formation of undesired by-products and the deactivation of the catalysts. This protocol allows for an efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives from easily available tertiary amines, olefins and CO.
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, P. R. China. aiwenlei@whu.edu.cn.
authors.forename: Renyi
authors.initials: R
authors.lastname: Shi
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Lu
authors.forename: Pei
authors.initials: P
authors.lastname: Gan
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Sha
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003640:Dealkylation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000577:Amides; D000588:Amines; D010165:Palladium; D003300:Copper; D002248:Carbon Monoxide