title: Antenatal Maternal Antidepressants Drugs Affect S100B Concentrations in Fetal-Maternal Biological Fluids.
abstract: BACKGROUND
  Antidepressant treatment during pregnancy is speedily increasing in developed countries and this phenomenon has occurred without firm evidence on safety and/or efficacy.
  
  
  OBJECTIVE
  The present study investigated from mid-trimester of pregnancy up to 24 hours after birth the pattern of a brain damage marker, namely S100B, in maternal fetal and neonatal biological fluids of pregnant women and their newborns antenatally treated by antidepressant drugs such as selective serotonin re-uptake inhibitors (SSRI).
  
  
  METHODS
  we conducted an observational study on 75 pregnant women treated in the mid -third trimester by antidepressant drugs and 231 healthy pregnancies. S100B concentrations were measured at 7 predetermined monitoring time-points before, during and after treatment in maternal, fetal and neonatal biological fluids and correlated with neurological follow-up at 7 days from birth.
  
  
  RESULTS
  In SSRI group S100B concentrations were significantly higher in SSRI than controls (P<0.001, for all) in maternal blood, in amniotic fluid, in arterial and venous cord blood and at 24-h from birth. Highest (P<0.05) S100B levels were found in SSRI infants showing major neurological symptoms at 7-d follow-up.
  
  
  CONCLUSIONS
  The present data on increased S100B levels in maternal, fetal and neonatal biological fluids suggest that SSRI administration although beneficial to the mother, presents some risks for the infant.
authors.forename: Valentina
authors.initials: V
authors.lastname: Bellissima
authors.forename: Gerard H A
authors.initials: GH
authors.lastname: Visser
authors.forename: Tessa F
authors.initials: TF
authors.lastname: Ververs
authors.forename: Frank van
authors.initials: Fv
authors.lastname: Bel
authors.forename: Jacqueline U M
authors.initials: JU
authors.lastname: Termote
authors.forename: Marja van der
authors.initials: Mv
authors.lastname: Heide
authors.affiliation: Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital, Spalto Marengo 46, 15100 Alessandria, Italy. dgazzolo@hotmail.com.
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D033261:Maternal-Fetal Relations; D011247:Pregnancy; D009418:S100 Proteins / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D009418:S100 Proteins; D017367:Selective Serotonin Reuptake Inhibitors