title: Thrombolysis in pediatric stroke study.
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rivkin
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Gabrielle
authors.initials: G
authors.lastname: deVeber
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Ichord
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Adam
authors.initials: A
authors.lastname: Kirton
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Chan
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Collin A
authors.initials: CA
authors.lastname: Hovinga
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Joan Cox
authors.initials: JC
authors.lastname: Gill
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Aniko
authors.initials: A
authors.lastname: Szabo
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Kelley
authors.initials: K
authors.lastname: Scholz
authors.affiliation: From the Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA (M.J.R.); Division of Neurology, Department of Pediatrics, Hospital for Sick Children Toronto, Ontario, Canada (G.d.V.); The Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.N.I.); Department of Neurology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada Alberta Children's Hospital (A.K.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (M.D.H.), University of Calgary, Alberta, Canada; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada (A.C.); Dell Children's Medical Center and University of Texas at Austin College of Pharmacy (C.A.H.); BloodCenter of Wisconsin and Department of Pediatrics (J.C.G.) and Division of Biostatistics (A.S.), Medical College of Wisconsin, Milwaukee; Center for Integrated Brain Research, Seattle Children's Research Institute, WA (K.S.); and Seattle Children's Hospital, Department of Neurology, University of Washington, Seattle (C.A.-L.).
authors.forename: Catherine
authors.initials: C
authors.lastname: Amlie-Lefond
mesh_terms: D000293:Adolescent; D001499:Bayes Theorem; D002309:Cardiology / Q000379:methods; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012720:Severity of Illness Index; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: stroke; therapeutic thrombolysis