title: The mechanisms of radiation-induced bystander effect.
abstract: The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo studies. Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.
authors.affiliation: Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Najafi
authors.affiliation: Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Fardid
authors.affiliation: Department of Radiology, School of paramedical sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Gh
authors.initials: G
authors.lastname: Hadadi
authors.affiliation: Health Management and Economics Research Center, Iran University of Medical Science, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Fardid
keywords: Bystander effect; Epigenetic; Free radicals; Immune system; Mitochondria