title: Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds.
abstract: Diabetic wounds remain a global unsolved problem and the cost of diabetes-related amputations and diabetic wound treatment is approximately US$3 billion and US$9 billion per year, respectively. Diabetic foot ulcers (DFUs) occur in 15% of all patients with diabetes and precede 84% of all diabetes-related lower leg amputations. Currently, there is no satisfying treatment for these hard-to-heal-wounds. However, as we discuss here, experimental preclinical evidence for the successful use of adult stem cell therapies for diabetic wounds gives new hope for the development of effective treatments for use in the clinic.
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany.
authors.forename: Hannes
authors.initials: H
authors.lastname: Heublein
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany.
authors.forename: Augustinus
authors.initials: A
authors.lastname: Bader
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, D-04103 Leipzig, Germany. Electronic address: shibashish.giri@bbz.uni-leipzig.de.
authors.forename: Shibashish
authors.initials: S
authors.lastname: Giri
mesh_terms: D000671:Amputation, Surgical; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D017719:Diabetic Foot / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage; D010641:Phenotype; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D016896:Treatment Outcome; D014945:Wound Healing