title: Manipulating IL-10 signalling blockade for better immunotherapy.
abstract: Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels of interleukin 10 in peripheral blood. Serum IL-10 levels are also high in certain cancers. Blocking IL-10 signalling at the time of immunisation clears chronic viral infection and prevents tumour growth in animal models. We review recent advances in this area, with the emphasis on potential use of this novel strategy to treat chronic viral infection and cancer in human.
authors.affiliation: School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia.
authors.forename: Guoying
authors.initials: G
authors.lastname: Ni
authors.affiliation: Genecology Research Centre, University of Sunshine Coast, Sippy Downs 4556, QLD, Australia.
authors.forename: Tianfang
authors.initials: T
authors.lastname: Wang
authors.affiliation: Inflammation and Healing Research Cluster, University of Sunshine Coast, Sippy Downs 4556, Australia.
authors.forename: Shelley
authors.initials: S
authors.lastname: Walton
authors.affiliation: Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Chen
authors.affiliation: Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China.
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Wu
authors.affiliation: Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China. Electronic address: yjwang@fsyyy.com.
authors.forename: Yuejian
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia. Electronic address: m.wei@griffith.edu.au.
authors.forename: Ming Q
authors.initials: MQ
authors.lastname: Wei
authors.affiliation: Inflammation and Healing Research Cluster, University of Sunshine Coast, Sippy Downs 4556, Australia; Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, China. Electronic address: xiaosongl@yahoo.com.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology* / Q000628:therapy; D019694:Hepatitis B, Chronic / Q000276:immunology* / Q000628:therapy; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D016753:Interleukin-10 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology
chemical_list: D016753:Interleukin-10
keywords: Immunotherapy; Interleukin 10; Vaccine