title: Staghorn Sumac Reduces 5-Fluorouracil-Induced Toxicity in Normal Cells.
abstract: Edible staghorn sumac (Rhus hirta) fruit extract was applied in conjunction with chemotherapeutic drug 5-fluorouracil to promote cytotoxicity of the drugs toward human breast cancer cells MCF-7 while protecting normal cells MCF-10A from drug toxicity. Sumac extract would be a promising chemotherapeutic drug conjugate in cancer chemotherapy.
authors.affiliation: 1 Canadian Food and Wine Institute, Niagara College , Niagara-on-the-Lake, Canada .
authors.forename: Sunan
authors.initials: S
authors.lastname: Wang
authors.affiliation: 2 School of Chemical Sciences, University of Auckland , Auckland, New Zealand .
authors.forename: Fan
authors.initials: F
authors.lastname: Zhu
authors.affiliation: 3 Department of Food Science, University of Guelph , Guelph, Canada .
authors.forename: Massimo F
authors.initials: MF
authors.lastname: Marcone
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000633:toxicity; D001943:Breast Neoplasms / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D029045:Rhus / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D010936:Plant Extracts; D005472:Fluorouracil
keywords: 5-fluorouracil; chemotherapeutic drug; staghorn sumac; toxicity