title: The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial.
abstract: High plasma level of P-selectin is associated with the development of venous thromboembolism (VTE). Furthermore, supplementation of vitamin D could decrease thrombotic events. Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE. In the randomized controlled trial, 60 patients with confirmed acute deep vein thrombosis and/or pulmonary embolism (PE) were randomized into the intervention (n = 20) and control (n = 40) groups. The intervention arm was given an intramuscular single dose of 300 000 IU vitamin D3 Plasma level of 25-hydroxy vitamin D, P-selectin, and high-sensitive C-reactive protein (hs-CRP) was measured at baseline and 4 weeks after. The plasma level of P-selectin (95% confidence interval = -5.99 to -1.63, P = .022) and hs-CRP (P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group (P = .011). However, the magnitude of these reductions was not statistically significant. This study could not support the potential benefit of the high-dose vitamin D on plasma level of P-selectin and hs-CRP in patients with VTE.
authors.affiliation: Research Center for Rational Use of Drugs and Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Kheirollah
authors.initials: K
authors.lastname: Gholami
authors.affiliation: Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azita Hajhossein
authors.initials: AH
authors.lastname: Talasaz
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Shahid Madani Heart Center and Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran tentezari@gmail.com entezarim@tbzmed.ac.ir.
authors.forename: Taher
authors.initials: T
authors.lastname: Entezari-Maleki
authors.affiliation: Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Salarifar
authors.affiliation: Research Center for Rational Use of Drugs and Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Molouk
authors.initials: M
authors.lastname: Hadjibabaie
authors.affiliation: Research Center for Rational Use of Drugs and Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Javadi
authors.affiliation: Department of Pediatrics, Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Dousti
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Hamishehkar
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saleh
authors.initials: S
authors.lastname: Maleki
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood / Q000187:drug effects; D011655:Pulmonary Embolism / Q000097:blood / Q000188:drug therapy; D054556:Venous Thromboembolism / Q000097:blood / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000097:blood / Q000188:drug therapy
chemical_list: D019007:P-Selectin; C546937:SELP protein, human; D002762:Cholecalciferol; D002097:C-Reactive Protein
keywords: DVT; P-selectin; PE; hs-CRP; thromboembolism; vitamin D