title: Highly Sensitive and Selective Field-Effect-Transistor NonEnzyme Dopamine Sensors Based on Pt/Conducting Polymer Hybrid Nanoparticles.
abstract: Dopamine (DA), as one of catecholamine family of neurotransmitters, is crucially important in humans owing to various critical effects on biometric system such as brine circuitry, neuronal plasticity, organization of stress responses, and control of cardiovascular and renal organizations. Abnormal level of dopamine in the central nervous system causes several neurological diseases, e.g., schizophrenia, Parkinson's disease, and attention deficit hybperactivity disorder (ADHD)/attention deficit disorder (ADD). In this report, we suggest the fabrication of nonenzyme field effect transistor (FET) sensor composed of immobilized Pt particle decorated conducting-polymer (3-carboxylate polypyrrole) nanoparticles (Pt_CPPy) to detect dopamine. The hybrid nanoparticles (NPs) are produced by means of facile chemical reduction of pristine CPPyNP-contained Pt precursor (PtCl4 ) solution. The Pt_CPPys are then immobilized on an amine-functionalized (-NH2 ) interdigitated-array electrode substrate, through the formation of covalent bonds with amine groups (-CONH). The resulting Pt_CPPy-based FET sensors exhibit high sensitivity and selectivity toward DA at unprecedentedly low concentrations (100 × 10(-15) m) and among interfering biomolecules, respectively. Additionally, due to the covalent bonding involved in the immobilization process, a longer lifetime is expected for the FET sensor.
authors.affiliation: School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul, 151-742, South Korea.
authors.forename: Jun Seop
authors.initials: JS
authors.lastname: Lee
authors.affiliation: School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul, 151-742, South Korea.
authors.forename: Jungkyun
authors.initials: J
authors.lastname: Oh
authors.affiliation: School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul, 151-742, South Korea.
authors.forename: Sung Gun
authors.initials: SG
authors.lastname: Kim
authors.affiliation: School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul, 151-742, South Korea.
authors.forename: Jyongsik
authors.initials: J
authors.lastname: Jang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004298:Dopamine / Q000032:analysis*; D004553:Electric Conductivity; D004566:Electrodes; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010984:Platinum / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry; D013696:Temperature; D014173:Transistors, Electronic
chemical_list: D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D010984:Platinum; D004298:Dopamine
keywords: biosensor; dopamine; nanoparticles; platinum; polypyrrole