title: [Multiple risk factors models of patients with acute coronary syndromes of different genders].
abstract: OBJECTIVE
  To establish the multiple risk factors models for patients with acute coronary syndromes (ACS) of different genders and quantitatively assess the pathopoiesis of all factors.
  
  
  METHODS
  A total of 2 308 consecutive ACS inpatients and a control group of 256 cases with normal coronary artery from January 2010 to December 2012 were enrolled and divided into 4 groups of female ACS (n = 970), male ACS (n = 1 338), female control (n = 136) and male control (n = 120). All demographic and clinical data were collected by the physicians and master degree candidates in the division of cardiology.
  
  
  RESULTS
  The Logistic regression models of multiple risk factors were established for ACS by different genders. More than 45 years of age, dyslipidemia, type 2 diabetes mellitus, obesity and hypertension were all independent risk factors of ACS for different genders (P < 0.05). However, the same risk factors had different pathogenic effects on ACS between genders. The odds ratio (OR) was markedly different for females and males: per 5-year increase aged over 45 years (1.45 vs 1.13), dyslipidemia (3.45 vs 1.68), type 2 diabetes mellitus (4.06 vs 2.33), obesity (2.93 vs 1.91) and hypertension (1.78 vs 3.80) respectively (all P < 0.05). In addition, current smoking increased the risk of ACS attack in males by 5.49 (P < 0.05) while not statistically significant in females. Particularly cerebral ischemic stroke increased the risk of ACS attack by 5.49 folds in males other than females (P < 0.05).
  
  
  CONCLUSIONS
  Type 2 diabetes mellitus, dyslipidemia and obesity may present higher risks of ACS attack for females than males. And smoking and hypertension are much more dangerous for males. Males with cerebral infarction are more susceptible for ACS than females.
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Wanglexian
authors.initials: W
authors.lastname: Sun
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Hu
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Xiansheng
authors.initials: X
authors.lastname: Huang
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Jinrui
authors.initials: J
authors.lastname: Guo
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Shi
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Huarong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Division of Cardiovascular Medicine, Institute of Cardiovascular Medicine, Affiliated Hospital, Chengde Medical College, Chengde 067000, China. Email: lichunhua9522@163.com.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome; D003924:Diabetes Mellitus, Type 2; D050171:Dyslipidemias; D005260:Female; D006801:Humans; D006973:Hypertension; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016017:Odds Ratio; D012307:Risk Factors; D012727:Sex Characteristics; D012907:Smoking