title: Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1.
abstract: Epigenetic mechanisms are fundamental in cardiac adaptations, remodeling, reverse remodeling, and disease. This two-article series proposes that variable forces associated with diastolic RV/LV rotatory intraventricular flows can exert physiologically and clinically important, albeit still unappreciated, epigenetic actions influencing functional and morphological cardiac adaptations and/or maladaptations. Taken in toto, the two-part survey formulates a new paradigm in which intraventricular diastolic filling vortex-associated forces play a fundamental epigenetic role, and examines how heart cells react to these forces. The objectives are to provide a perspective on vortical epigenetic effects, to introduce emerging ideas, and to suggest directions of multidisciplinary translational research. The main goal is to make pertinent biophysics and cytomechanical dynamic systems concepts accessible to interested translational and clinical cardiologists. I recognize that the diversity of the epigenetic problems can give rise to a diversity of approaches and multifaceted specialized research undertakings. Specificity may dominate the picture. However, I take a contrasting approach. Are there concepts that are central enough that they should be developed in some detail? Broadness competes with specificity. Would, however, this viewpoint allow for a more encompassing view that may otherwise be lost by generation of fragmented results? Part 1 serves as a general introduction, focusing on background concepts, on intracardiac vortex imaging methods, and on diastolic filling vortex-associated forces acting epigenetically on RV/LV endocardium and myocardium. Part 2 will describe pertinent available pluridisciplinary knowledge/research relating to mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations and to their epigenetic actions on myocardial and ventricular function and adaptations.
authors.affiliation: Department of Surgery, Duke University School of Medicine, Durham, NC, 27710, USA, apasipou@duke.edu.
authors.forename: Ares
authors.initials: A
authors.lastname: Pasipoularides
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001696:Biomechanical Phenomena; D003952:Diagnostic Imaging / Q000379:methods; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D005838:Genotype; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000235:genetics*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000235:genetics*; D010641:Phenotype; D016277:Ventricular Function, Left / Q000235:genetics*; D016278:Ventricular Function, Right / Q000235:genetics*; D020257:Ventricular Remodeling / Q000235:genetics