title: Brazilian red propolis attenuates hypertension and renal damage in 5/6 renal ablation model.
abstract: The pathogenic role of inflammation and oxidative stress in chronic kidney disease (CKD) is well known. Anti-inflammatories and antioxidant drugs has demonstrated significant renoprotection in experimental nephropathies. Moreover, the inclusion of natural antioxidants derived from food and herbal extracts (such as polyphenols, curcumin and lycopene) as an adjuvant therapy for slowing CKD progression has been largely tested. Brazilian propolis is a honeybee product, whose anti-inflammatory, antimicrobial and antioxidant effects have been widely shown in models of sepsis, cancer, skin irritation and liver fibrosis. Furthermore, previous studies demonstrated that this compound promotes vasodilation and reduces hypertension. However, potential renoprotective effects of propolis in CKD have never been investigated. The aim of this study was to evaluate the effects of a subtype of Brazilian propolis, the Red Propolis (RP), in the 5/6 renal ablation model (Nx). Adult male Wistar rats underwent Nx and were divided into untreated (Nx) and RP-treated (Nx+RP) groups, after 30 days of surgery; when rats already exhibited marked hypertension and proteinuria. Animals were observed for 90 days from the surgery day, when Nx+RP group showed significant reduction of hypertension, proteinuria, serum creatinine retention, glomerulosclerosis, renal macrophage infiltration and oxidative stress, compared to age-matched untreated Nx rats, which worsened progressively over time. In conclusion, RP treatment attenuated hypertension and structural renal damage in Nx model. Reduction of renal inflammation and oxidative stress could be a plausible mechanism to explain this renoprotection.
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Flávio
authors.initials: F
authors.lastname: Teles
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Tarcilo Machado
authors.initials: TM
authors.lastname: da Silva
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Francisco Pessoa
authors.initials: FP
authors.lastname: da Cruz Júnior
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Vitor Hugo
authors.initials: VH
authors.lastname: Honorato
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: de Oliveira Costa
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Ana Paula Fernandes
authors.initials: AP
authors.lastname: Barbosa
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Sabrina Gomes
authors.initials: SG
authors.lastname: de Oliveira
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, State University of Health Sciences, Alagoas, Brazil.
authors.forename: Zenaldo
authors.initials: Z
authors.lastname: Porfírio
authors.affiliation: Faculty of Medicine, Federal University, Ceará, Brazil.
authors.forename: Alexandre Braga
authors.initials: AB
authors.lastname: Libório
authors.affiliation: School of Sport and Exercise Science, University of Northern Colorado, Greeley, United States of America.
authors.forename: Raquel Lerner
authors.initials: RL
authors.lastname: Borges
authors.affiliation: Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Camilla
authors.initials: C
authors.lastname: Fanelli
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009392:Nephrectomy; D011429:Propolis / Q000008:administration & dosage* / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar; D051436:Renal Insufficiency, Chronic / Q000517:prevention & control
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D011429:Propolis; D003404:Creatinine