title: [Complete response of locally recurrent anorectal cancer to proton beam therapy alone--a case report].
abstract: We report a case of locally recurrent anorectal cancer treated with proton beam therapy (PBT) alone that led to a clinically complete response. A 70-year-old woman with paraparesis due to infantile paralysis underwent abdominoperineal resection (APR) and D3 lymphadenectomy for anorectal cancer (PERb, type 2, 50×40 mm, muc-tub1, M1a[lung], Stage IV a]. Three months after APR, right middle and right lower lobectomies were performed for synchronous lung metastases. Adjuvant chemotherapy was not administered. One year and 8 months after APR, computed tomography (CT) showed local recurrence of the tumor (29×28 mm), which contacted the right ischial spine. Pelvic exenteration combined with sacral resection was not performed because of the patient's poor performance status. PBT (70 Gy [RBE]/25 F/5 week) was administered for treatment of the recurred tumor. CT revealed that the tumor disappeared 1 year after PBT, which was defined as complete response. The patient is alive and has not experienced recurrence for 7 years.
authors.affiliation: Division of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ie
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kinugasa
authors.forename: Sumito
authors.initials: S
authors.lastname: Sato
authors.forename: Yushi
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kagawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomioka
authors.forename: Akio
authors.initials: A
authors.lastname: Shiomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fuji
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murayama
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D061766:Proton Therapy; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed