title: Emerging players in prostate cancer: long non-coding RNAs.
abstract: Recent observations of novel long non-coding RNAs (lncRNAs) have considerably altered our understanding of cell biology. The role of lncRNAs as tumor suppressors or oncogenes has been extensively studied. Over-expression of oncogenic lncRNAs promotes tumor-cell proliferation and metastasis through chromatin looping and distal engagement with the androgen receptor, anti-sense gene regulation, alternative splicing, and impeding DNA repair. Prostate cancer is the most common type of cancer and frequent cause of cancer-related mortality in men worldwide. Unraveling the molecular and biological processes that contribute to prostate cancer development and progression is a challenging task. In prostate cancer, aberrant expression of lncRNAs has been associated with disease progression. In this review, we highlight the emerging impact of lncRNAs in prostate cancer research, with a particular focus on the mechanisms and functions of lncRNAs. Increased research on lncRNAs will lead to a greater understanding of prostate cancercinogenesis and progression and may lead to novel clinical applications. LncRNAs have great potential to become new biomarkers for detection, prognostication and prediction in prostate cancer.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Pathology, Beth-Israel Deaconess Medical Center, Harvard Medical School USA.
authors.forename: Huihui
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Harvard Medical School USA.
authors.forename: Chin-Lee
authors.initials: CL
authors.lastname: Wu
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School USA.
authors.forename: Gwo-Shu Mary
authors.initials: GS
authors.lastname: Lee
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School USA.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kantoff
keywords: Long non-coding RNAs; lncRNAs; prostate cancer