title: Ligand-promoted ortho-C-H amination with Pd catalysts.
abstract: 2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable Pd(II)-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups.
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Dajian
authors.initials: D
authors.lastname: Zhu
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Ling
authors.initials: L
authors.lastname: Chu
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Martin D
authors.initials: MD
authors.lastname: Eastgate
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
keywords: CH activation; amination; benzamide; benzylamine; pyridine ligands