title: Mesenchymal stem cells transplantation for systemic lupus erythematosus.
abstract: Mesenchymal stem cells are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. They can suppress proliferation or functions of many immune cells such as T cells, B cells, natural killer cells and dendritic cells. Recently, a substantial progress has been made in the field of mesenchymal stem cell transplantation. Experimental and clinical data suggest that this therapy has been a promising strategy for severe and refractory systemic lupus erythematosus.
authors.affiliation: Department of Immunology and Rheumatology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Lingyun
authors.initials: L
authors.lastname: Sun
mesh_terms: D064591:Allografts; D018450:Disease Progression; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000401:mortality* / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods* / Q000401:mortality; D011379:Prognosis; D018570:Risk Assessment; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome
keywords: mesenchymal stem cells; systemic lupus erythematosus; transplantation