title: The neonatal Fc receptor does not modulate hepatitis C virus neutralization.
abstract: The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Morel
authors.affiliation: UMR CNRS 7292, Université François Rabelais and CHRU de Tours, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Passot
authors.affiliation: UMR CNRS 7292, Université François Rabelais and CHRU de Tours, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Arnoult
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Dumans
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Beaumont
authors.affiliation: UMR CNRS 7292, Université François Rabelais and CHRU de Tours, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gouilleux-Gruart
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Roingeard
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Blanchard
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology* / Q000378:metabolism*; D000914:Antibodies, Viral / Q000276:immunology* / Q000378:metabolism*; D016174:Hepacivirus / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D009500:Neutralization Tests; D011961:Receptors, Fc / Q000378:metabolism*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015395:Histocompatibility Antigens Class I; D011961:Receptors, Fc; C100688:Fc receptor, neonatal