title: Ultrasonic mediated synthesis of monodispersed lanthanum hydroxide nanorods for possible bioimplant application.
abstract: Monodispersed lanthanum hydroxide nano-rods (LaNRs) were synthesized for prospective biomedical application using a microwave heating and ultrasonic agitation methodology which does not require any toxic stabilizing agent. The average length and diameter of the LaNRs thus obtained were 183.4 ± 3.6 and 9.9 ± 0.2 nm respectively, as analyzed by HRTEM. FTIR spectrum confirmed the presence of OH groups. The thermal transformation of lanthanum hydroxide (La(OH)3) was studied by thermogravimetric analysis. The synthesized LaNRs were found to be stable for a period of 1 month at room temperature. They were biocompatible as evaluated by haemocompatibility assay and viability assay using human peripheral blood mononuclear cells. The pro-angiogenic property of LaNRs was demonstrated by in vivo chick chorioallantoic membrane assay. The LaNRs induced osteoblast differentiation of human adipose derived stem cells with significant calcium (Ca(2+)) deposition indicating potential applications in bone tissue engineering.
authors.affiliation: Biochemistry Laboratory, Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, 600 020, India.
authors.forename: Dhandapani
authors.initials: D
authors.lastname: Harini
authors.forename: Anantanarayanan
authors.initials: A
authors.lastname: Rajaram
authors.forename: Rama
authors.initials: R
authors.lastname: Rajaram
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002417:Cattle; D002454:Cell Differentiation; D002470:Cell Survival; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000378:metabolism; D006801:Humans; D006878:Hydroxides / Q000737:chemistry; D007477:Ions; D007811:Lanthanum / Q000737:chemistry*; D007963:Leukocytes, Mononuclear / Q000166:cytology; D043942:Nanotubes; D010006:Osteoblasts / Q000166:cytology; D011446:Prospective Studies; D017550:Spectroscopy, Fourier Transform Infrared; D013234:Stem Cells / Q000166:cytology; D013696:Temperature; D013818:Thermogravimetry; D023822:Tissue Engineering / Q000379:methods; D014465:Ultrasonics
chemical_list: D001672:Biocompatible Materials; D006878:Hydroxides; D007477:Ions; C033562:lanthanum hydroxide; D007811:Lanthanum; D002118:Calcium