title: Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis.
abstract: Marine sponges are a potential source of new molecules with diverse biological activities. We have previously isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa. The aim of this study was to test Haliscosamine in vitro and in vivo for its antifungal activity against Fusarium oxysporum f.sp. melonis causing fusarium wilt of melon. Overall, in vitro test showed that haliscosamine has a similar effect as DESOGERME SP VEGETAUX®. In addition, in vivo showed a significant effect against Fusarium oxysporum f.sp. melonis. Taking to gather, our results suggest that haliscosamine constitutes a potential candidate against Fusarium oxysporum f.sp. melonis and the possibility to use in phytopathology.
authors.affiliation: Faculté Polydisciplinaire de Taroudant, Université Ibn Zohr, Taroudant, Maroc ; Laboratoire Contrôle Qualité en Bio-Industrie et Molécules Bio-Actives, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.
authors.forename: Belakssem
authors.initials: B
authors.lastname: El Amraoui
authors.affiliation: Laboratoire MMS, Faculté de Pharmacie Université de Nantes, Nantes, France.
authors.forename: Jean François
authors.initials: JF
authors.lastname: Biard
authors.affiliation: Laboratoire de Physiologie végétale et phytopathologie, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.
authors.forename: Fatima Ez-Zohra
authors.initials: FE
authors.lastname: Ikbal
authors.affiliation: Laboratoire Contrôle Qualité en Bio-Industrie et Molécules Bio-Actives, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.
authors.forename: Majida
authors.initials: M
authors.lastname: El Wahidi
authors.affiliation: Laboratoire d'Anthropogénétiques et Biostatistiques, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Kandil
authors.affiliation: Laboratoire Contrôle Qualité en Bio-Industrie et Molécules Bio-Actives, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.
authors.forename: Mohammed
authors.initials: M
authors.lastname: El Amraoui
authors.affiliation: Laboratoire Contrôle Qualité en Bio-Industrie et Molécules Bio-Actives, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc ; Ecole Nationale du Commerce et de Gestion ENCG de Settat, Settat, Maroc.
authors.forename: Aziz
authors.initials: A
authors.lastname: Fassouane
keywords: Fusarium oxysporum; Haliclona; Haliscosamine; Marine sponges; Porifera