title: Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease.
abstract: Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.
authors.affiliation: From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544; §Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, 3086, Australia.
authors.forename: Rommel A
authors.initials: RA
authors.lastname: Mathias
authors.affiliation: From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544;
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Guise
authors.affiliation: From the ‡Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544; icristea@princeton.edu.
authors.forename: Ileana M
authors.initials: IM
authors.lastname: Cristea
mesh_terms: D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D024510:Muscle Development; D009474:Neurons / Q000201:enzymology; D010012:Osteogenesis; D011499:Protein Processing, Post-Translational; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D012097:Repressor Proteins; C400300:HDAC4 protein, human; C404500:HDAC5 protein, human; C543273:HDAC7 protein, human; C486544:HDAC9 protein, human; D006655:Histone Deacetylases