title: Molecular drivers of cellular metabolic reprogramming in melanoma.
abstract: The development of metastatic melanoma is accompanied by distinct changes in cellular metabolism, most notably a change in strategy for energy production from mitochondrial oxidative phosphorylation to cytoplasmic aerobic glycolysis. This bioenergetic switch occurs at the expense of less-efficient utilization of glucose, but is required for melanoma cells to meet their bioenergetic and biosynthetic demands. Recent work has implicated well-established melanoma drivers such as BRAF, PTEN, MITF, and ARF in the regulation of cellular energy metabolism. The metabolic changes in melanoma cells offer new opportunities for therapeutic intervention. However, inter- and intratumor bioenergetic heterogeneity caused by variation in genetic driver profiles and mitochondrial performance may impact on the effectiveness of treatment.
authors.affiliation: Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark.
authors.forename: Cecilie
authors.initials: C
authors.lastname: Abildgaard
authors.affiliation: Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address: perg@cancer.dk.
authors.forename: Per
authors.initials: P
authors.lastname: Guldberg
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D065150:Cellular Reprogramming / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D008928:Mitochondria / Q000378:metabolism; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF; melanoma; metabolism; mitochondria; oncogene