title: Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions.
abstract: Cancer researchers are currently embarking on one of their field's biggest challenges, namely the understanding of how cellular metabolism or certain classes of elite metabolites (e.g., oncometabolites) can directly influence chromatin structure and the functioning of epi-transcriptional circuits to causally drive tumour formation. We here propose that refining the inherent cell attractor nature of nuclear reprogramming phenomena by adding the under-appreciated capacity of metabolism to naturally reshape the Waddingtonian landscape's topography provides a new integrative metabolo-epigenetic model of the cancer stem cell (CSC) theory.
authors.affiliation: Metabolism & Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain ; Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Menendez
authors.affiliation: Metabolism & Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain ; Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain.
authors.forename: Bruna
authors.initials: B
authors.lastname: Corominas-Faja
authors.affiliation: Metabolism & Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain ; Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Cuyàs
authors.affiliation: Computational & Mathematical Biology Research Group, Centre de Recerca Matemàtica (CRM), Barcelona, Catalonia, Spain ; Departament de Matemàtiques, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Alarcón
keywords: Oncometabolites; cancer; cancer stem cells; reprogramming; stem cells; stemness