title: Xeroderma pigmentosum complementation group C protein (XPC) expression in basal cell carcinoma.
abstract: BACKGROUND
  The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BCC).
  
  
  OBJECTIVE
  To determine whether the XPC protein is associated with basal cell carcinoma.
  
  
  METHODS
  In the present study, we investigated the protein expression of XPC by immunohistochemistry in 86 cases of BCC and paired-adjacent normal epidermis.
  
  
  RESULTS
  The intensity of nuclear XPC expression was significantly higher in BCC compared to adjacent normal epidermis (p<0.001). Attenuated XPC expression was associated with high-risk BCC (p=0.045) but was not significantly associated with age, gender and body area.
  
  
  CONCLUSIONS
  Our results indicate that XPC is associated with BCC and further studies are warranted to determine if the XPC-BCC interaction is specific to just one cancer cell type and to investigate potential mechanisms.
authors.affiliation: Department of Bioindustry Technology, Dayeh University, Chang-Hua, Taiwan, R.O.C. Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Lien-Chuan
authors.initials: LC
authors.lastname: Yang
authors.affiliation: Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C. Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Hsiao
authors.affiliation: Division of Plastic Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chun-Te
authors.initials: CT
authors.lastname: Lu
authors.affiliation: Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Chun-Huang
authors.initials: CH
authors.lastname: Huang
authors.affiliation: Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C. Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Wan-Ru
authors.initials: WR
authors.lastname: Chao
authors.affiliation: Department of Medical Education, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Department of Medical Education, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Hsuan-An
authors.initials: HA
authors.lastname: Su
authors.affiliation: Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua County, Taiwan, R.O.C. jgchung@mail.cmu.edu.tw cutaneouscsmu@gmail.com.
authors.forename: Shih-Liang
authors.initials: SL
authors.lastname: Chang
authors.affiliation: Departments of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C. Department of Biotechnology, Asia University, Taichung, Taiwan, R.O.C. jgchung@mail.cmu.edu.tw cutaneouscsmu@gmail.com.
authors.forename: Jing-Gung
authors.initials: JG
authors.lastname: Chung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C086984:XPC protein, human
keywords: Basal cell carcinoma (BCC); Xeroderma pigmentosum complementation group C protein (XPC); skin cancer