title: Prognostic role of microRNA-205 in multiple human malignant neoplasms: a meta-analysis of 17 studies.
abstract: OBJECTIVE
  MicroRNA-205 (miRNA-205) was revealed as an attractive prognostic tumour biomarker in recent studies. However, the results of different studies have been inconsistent. We conducted a meta-analysis to elucidate the precise predictive value of miRNA-205 in various human malignant neoplasms.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  Qualified studies were identified up to 5 June 2014 by performing online searches in PubMed, EMBASE and Web of Science, and additional quality evaluations.
  
  
  METHODS
  Seventeen eligible studies with 4827 patients were ultimately enrolled in this meta-analysis.
  
  
  METHODS
  The heterogeneity between studies was assessed using I(2) statistics. Pooled HRs with 95% CIs for patient survival and disease recurrence were calculated to investigate the correlation between miRNA-205 expression and cancer prognosis.
  
  
  RESULTS
  Our results indicate that elevated miRNA-205 was significantly associated with enhanced overall survival in the breast cancer subgroup (HR=0.78, 95% CI 0.67 to 0.91) and superior disease-free survival/recurrence-free survival in the adenocarcinoma subgroup (HR=0.68, 95% CI 0.49 to 0.94).
  
  
  CONCLUSIONS
  miRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted.
authors.affiliation: From Department of Urology, The First Affiliated Hospital Of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: From Department of Plastic Surgery, Changhai Hospital Affiliated To Second Military Medical University, Shanghai, China.
authors.forename: Meng-Yan
authors.initials: MY
authors.lastname: Sun
authors.affiliation: From Department of Urology, The First Affiliated Hospital Of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Ning-Hong
authors.initials: NH
authors.lastname: Song
authors.affiliation: From Department of Urology, Affiliated Hospital Of Nanjing Medical University Of TCM, Nanjing, Jiangsu, China.
authors.forename: Zhong-Lei
authors.initials: ZL
authors.lastname: Deng
authors.affiliation: From Department of Plastic Surgery, Changhai Hospital Affiliated To Second Military Medical University, Shanghai, China.
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Xue
authors.affiliation: From Department of Urology, The First Affiliated Hospital Of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D012008:Recurrence; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; C534425:MIR205, human