title: Neuroblastoma in Children Under 12 Months in Singapore--15-Year Experience and Outcomes From KKH.
abstract: BACKGROUND
  Expectant observation of small adrenal lesions has shown promising results in recent studies. We present our 15 years outcome of managing infant neuroblastoma.
  
  
  METHODS
  All patients with neuroblastoma below the age of 1 year treated at the largest pediatric hospital in Singapore between 1998 and 2012 were identified.
  
  
  RESULTS
  Twenty-two patients were included in our study. Six were antenatally diagnosed. Nineteen (86%) patients had surgical resection of the tumor. Eight (36%) patients received chemotherapy as part of their treatment. Six patients were observed three of which had large adrenal tumors. Median follow-up in our series was 2.6 years. The 5 year overall survival was 90%. There were no recurrences and there were 2 deaths in our series.
  
  
  CONCLUSIONS
  Our series shows excellent outcomes of infant neuroblastoma at our center. Careful observation of large tumors may be an option to avoid the morbidity of surgery.
authors.affiliation: Radiation Oncology, National University Cancer Institute , Singapore , Singapore.
authors.forename: Vicky
authors.initials: V
authors.lastname: Koh
authors.forename: Shui Yen
authors.initials: SY
authors.lastname: Soh
authors.forename: Mei Yoke
authors.initials: MY
authors.lastname: Chan
authors.forename: Ah Moy
authors.initials: AM
authors.lastname: Tan
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D009447:Neuroblastoma / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy*; D011379:Prognosis; D012846:Singapore
keywords: neuroblastoma; observation; oncology