title: Stereotactic radiosurgery for intracranial meningiomas: current concepts and future perspectives.
abstract: Meningiomas are among the most common adult brain tumors. Although the optimal management of meningiomas would provide complete elimination of the lesion, this cannot always be accomplished safely through resection. Therefore, other therapeutic modalities, such as stereotactic radiosurgery (as primary or adjunctive therapy), have emerged. In the current review, we have provided an overview of the historical outcomes of various radiosurgical modalities applied in the management of meningiomas. Furthermore, we provide a discussion on key factors (eg World Health Organization grade, lesion size, and lesion location) that affect tumor control and adverse event rates. We discuss recent changes in our understanding of meningiomas, based on molecular and genetic markers, and how these will change our perspective on the management of meningiomas. We conclude by outlining the areas in which knowledge gaps persist and provide suggestions as to how these can be addressed.
authors.affiliation: *Division of Neurosurgery, University of Toronto, Toronto, Canada; ‡Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto Canada; §Departments of Neurosurgery and Radiation Oncology, NYU Langone Medical Center, New York University.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mansouri
authors.forename: Daipayan
authors.initials: D
authors.lastname: Guha
authors.forename: George
authors.initials: G
authors.lastname: Klironomos
authors.forename: Soroush
authors.initials: S
authors.lastname: Larjani
authors.forename: Gelareh
authors.initials: G
authors.lastname: Zadeh
authors.forename: Douglas
authors.initials: D
authors.lastname: Kondziolka
mesh_terms: D000328:Adult; D006801:Humans; D008577:Meningeal Neoplasms / Q000601:surgery*; D008579:Meningioma / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods* / Q000639:trends*; D016896:Treatment Outcome