title: Targeting cell migration in rheumatoid arthritis.
abstract: OBJECTIVE
  To provide an update of past failures, future prospects and key challenges facing the therapeutic targeting of chemokines and their receptors in rheumatoid arthritis.
  
  
  RESULTS
  Clinical trials in rheumatoid arthritis have been undertaken with small molecule antagonists or neutralizing antibodies targeting CCR1, CCR5 and CXCL10. Some encouraging results have emerged. Laboratory and clinical research has identified CCL19, CXCL13 and CXCL12, and their receptors, as potential future targets. Developments in our appreciation of posttranslational chemokine modification highlight the complexity of chemokine networks operating in inflamed tissues, and the substantial gaps in existing knowledge.
  
  
  CONCLUSIONS
  Despite previous disappointments, there are still reasons to be optimistic that drugs targeting chemokines and their receptors could be developed for the treatment of rheumatoid arthritis. However, a deeper understanding of the chemokine networks at work in inflamed joints is a necessary prerequisite.
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: Darren L
authors.initials: DL
authors.lastname: Asquith
authors.forename: Steven A
authors.initials: SA
authors.lastname: Bryce
authors.forename: Robert J B
authors.initials: RJ
authors.lastname: Nibbs
mesh_terms: D018501:Antirheumatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D002464:Cell Migration Inhibition / Q000187:drug effects*; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D018925:Chemokines; D019707:Receptors, Chemokine