title: Incorporation of polymerizable surfactants in hydroxyethyl methacrylate lenses for improving wettability and lubricity.
abstract: Dryness and discomfort are the main reasons for dropouts in contact lens wearers. Incorporating surfactants in lens formulations could improve wettability and lubricity, which can improve comfort. We have focused on incorporating polymerizable surfactants in hydroxyethyl methacrylate lenses to improve comfort, while minimizing the potential for surfactant release into the tears. The surfactants were added to the polymerization mixture, followed by UV curing and extraction of leachables in hot water. Wettability and lubricity were characterized by measuring the contact angle and coefficient of friction. Lenses were also characterized by measuring transmittance, loss and storage moduli and ion permeability. Incorporation of surfactants significantly reduced contact angle from 90° for p-HEMA gels to about 10° for 2.43% (w/w) surfactant loading in hydrated gel. The coefficient of friction also decreased from about 0.16 for HEMA gels to 0.05 for the gels with 2.43% surfactant loading. There was a good correlation between the contact angle and coefficient of friction suggesting that both effects can be related to the stretching of the surfactant tails near the surface into the aqueous phase. The water content was also correlated with the surfactant loading but the contact angle was more sensitive suggesting that the observed improvements in wettability and lubricity arise from the protrusion of the surfactant tails in into the liquid, and not purely from the increase in the water content. The gels were clear and certain compositions also have the capability to block UVC and UVB radiation. The results suggest that incorporation of polymerizable surfactants could be useful in improving surface properties without significantly impacting any bulk property.
authors.affiliation: Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, United States; Particle Engineering Research Center, University of Florida, Gainesville, FL 32611, United States.
authors.forename: Lokendrakumar C
authors.initials: LC
authors.lastname: Bengani
authors.affiliation: Particle Engineering Research Center, University of Florida, Gainesville, FL 32611, United States.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Scheiffele
authors.affiliation: Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, United States; Department of Ophthalmology, University of Florida, Gainesville, FL, United States. Electronic address: chauhan@che.ufl.edu.
authors.forename: Anuj
authors.initials: A
authors.lastname: Chauhan
mesh_terms: D003261:Contact Lenses; D008153:Lubrication; D008689:Methacrylates / Q000737:chemistry*; D058105:Polymerization; D013501:Surface-Active Agents / Q000737:chemistry*; D017155:Wettability
chemical_list: D008689:Methacrylates; D013501:Surface-Active Agents; C005044:hydroxyethyl methacrylate
keywords: Contact angle; Contact lenses; Friction; Lubricity; P-HEMA; Polymerizable surfactants; Wettability