title: High adipose LPL activity and adipocyte hypertrophy reduce visceral fat and metabolic risk in obese, older women.
abstract: OBJECTIVE
  To determine whether higher subcutaneous adipose tissue lipoprotein lipase activity (AT-LPLA) is associated with greater triglyceride (TG) storage in subcutaneous adipose tissue (SAT), thereby reducing visceral adipose tissue (VAT) accumulation and metabolic dysfunction.
  
  
  METHODS
  Obese postmenopausal women (60 ± 1 years, mean ± SEM; N = 101) had body composition measured by DXA and CT and had fat aspirations to measure fat cell weight (FCW) and AT-LPLA. Women were ranked by visceral to total abdominal fat ratio (VAT/TAF), and the lowest and highest groups (n = 24) matched for % fat and age.
  
  
  RESULTS
  The prevalence of metabolic dysfunction was 7- to 10-fold higher in women with high VAT/TAF (Ps < 0.01). Women with low VAT/TAF had 11% and 6% lower abdominal and gluteal FCW but 28% and 54% higher AT-LPLA/10(6) cells in abdominal and gluteal fat, respectively. Abdominal FCW correlated with AT-LPLA in women with low (r = 0.63, P < 0.01) but not high (r = 0.14, P = 0.52) VAT/TAF, and these lines differed in slope (P < 0.05) and intercept (P < 0.01), suggesting greater capacity for TG storage with low VAT/TAF. There were no relationships between gluteal FCW and AT-LPLA. The relationship between SAT and abdominal AT-LPLA (r = 0.39, P < 0.01) suggests that higher AT-LPLA promotes TG storage.
  
  
  CONCLUSIONS
  These results suggest that higher AT-LPLA is associated with SAT adipocyte hypertrophy, which reduces visceral adiposity and metabolic risk in obese, older women.
authors.affiliation: Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA; Baltimore Geriatric Research, Education and Clinical Center, VA Maryland Health Care System, Baltimore, Maryland, USA.
authors.forename: Monica C
authors.initials: MC
authors.lastname: Serra
authors.forename: Alice S
authors.initials: AS
authors.lastname: Ryan
authors.forename: John D
authors.initials: JD
authors.lastname: Sorkin
authors.forename: Knachelle H
authors.initials: KH
authors.lastname: Favor
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Goldberg
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology*; D050154:Adiposity; D001823:Body Composition; D001835:Body Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006984:Hypertrophy; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism; D017698:Postmenopause / Q000378:metabolism; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism
chemical_list: C548261:LPL protein, human; D008071:Lipoprotein Lipase