title: Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma.
abstract: Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the management of BE and early EAC. To aid clinical decision making in this rapidly moving field, Cancer Council Australia convened an expert working party to identify pertinent clinical questions. The questions covered a wide range of topics including endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE; and methods for managing BE and early EAC. The latter considered modification of lifestyle factors; screening and surveillance strategies; and medical, endoscopic, and surgical interventions. To answer each question, the working party systematically reviewed the literature and developed a set of recommendations through consensus. Evidence underpinning each recommendation was rated according to quality and applicability.
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: David C
authors.initials: DC
authors.lastname: Whiteman
authors.forename: Mark
authors.initials: M
authors.lastname: Appleyard
authors.forename: Farzan F
authors.initials: FF
authors.lastname: Bahin
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Bobryshev
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bourke
authors.forename: Ian
authors.initials: I
authors.lastname: Brown
authors.forename: Adrian
authors.initials: A
authors.lastname: Chung
authors.forename: Andrew
authors.initials: A
authors.lastname: Clouston
authors.forename: Emma
authors.initials: E
authors.lastname: Dickins
authors.forename: Jon
authors.initials: J
authors.lastname: Emery
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
authors.forename: Louisa G
authors.initials: LG
authors.lastname: Gordon
authors.forename: Florian
authors.initials: F
authors.lastname: Grimpen
authors.forename: Geoff
authors.initials: G
authors.lastname: Hebbard
authors.forename: Laura
authors.initials: L
authors.lastname: Holliday
authors.forename: Luke F
authors.initials: LF
authors.lastname: Hourigan
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Kendall
authors.forename: Eric Yt
authors.initials: EY
authors.lastname: Lee
authors.forename: Angelique
authors.initials: A
authors.lastname: Levert-Mignon
authors.forename: Reginald V
authors.initials: RV
authors.lastname: Lord
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Lord
authors.forename: Derek
authors.initials: D
authors.lastname: Maule
authors.forename: Alan
authors.initials: A
authors.lastname: Moss
authors.forename: Ian
authors.initials: I
authors.lastname: Norton
authors.forename: Ian
authors.initials: I
authors.lastname: Olver
authors.forename: Darren
authors.initials: D
authors.lastname: Pavey
authors.forename: Spiro
authors.initials: S
authors.lastname: Raftopoulos
authors.forename: Shan
authors.initials: S
authors.lastname: Rajendra
authors.forename: Mark
authors.initials: M
authors.lastname: Schoeman
authors.forename: Rajvinder
authors.initials: R
authors.lastname: Singh
authors.forename: Freddy
authors.initials: F
authors.lastname: Sitas
authors.forename: B Mark
authors.initials: BM
authors.lastname: Smithers
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Taylor
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Thomas
authors.forename: Iain
authors.initials: I
authors.lastname: Thomson
authors.forename: Henry
authors.initials: H
authors.lastname: To
authors.forename: Jutta
authors.initials: J
authors.lastname: von Dincklage
authors.forename: Christine
authors.initials: C
authors.lastname: Vuletich
authors.forename: David I
authors.initials: DI
authors.lastname: Watson
authors.forename: Ian F
authors.initials: IF
authors.lastname: Yusoff
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001315:Australia; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor / Q000032:analysis; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004945:Esophagoscopy; D005544:Forecasting; D006801:Humans; D017410:Practice Guidelines as Topic; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Barrett's esophagus; clinical practice; esophageal adenocarcinoma; guidelines