title: [Influence of betahistine on the expression of histamine H3 receptor in the medial vestibular nucleus following unilateral labyrinthectomy in guinea pigs].
abstract: OBJECTIVE
  To observe the influence of betahistine on the expression of histamine H3 receptor in the medial vestibular nucleus (MVN) following unilateral labyrinthectomy (UL).
  
  
  METHODS
  Fifty-six healthy guinea pigs were randomly divided into three groups:the sham-operated group (group I), the UL group[group II, and UL+betahistine (BET) group (group III)], BET was intraperitoneally injection at 2.17 mg×kg(-1)×d(-1) for 7 days. The expression of histamine H3 receptor was analyzed by immunohistochemistry at 1 day, 3 days and 7 days after UL.
  
  
  RESULTS
  H3 receptors were presented in the MVN and the expression of histamine H3 receptor were increased significantly in the ipsilateral MVN at 1 and 3 days after UL(P < 0.05), the change turned into the normal value at 7 days(P > 0.05). In the UL+BET group, the intensity of histamine H3 receptor was lower than that in the UL at 1 day and 3 days(4.25 ± 0.71, 3.50 ± 0.92 vs 5.75 ± 0.71, 5.50 ± 0.93, P < 0.05). However, the changes turned into the normal values at 3 and 7 days (P > 0.05).
  
  
  CONCLUSIONS
  The early stage of the vestibular compensation process may be associated with the change of H3 receptor expression in MVN. In the UL+BET group the histamine H3 receptor recovered quickly.
authors.affiliation: Deparrment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Shu
authors.affiliation: Deparrment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Email: shihuayin@126.com.
authors.forename: Shihua
authors.initials: S
authors.lastname: Yin
authors.affiliation: Deparrment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Deparrment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Rao
authors.affiliation: Deparrment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Shunlian
authors.initials: S
authors.lastname: Wei
mesh_terms: D000818:Animals; D001621:Betahistine / Q000378:metabolism*; D007758:Ear, Inner; D006168:Guinea Pigs; D013506:Otologic Surgical Procedures; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000601:surgery*
chemical_list: D018100:Receptors, Histamine H3; D001621:Betahistine