title: Costs and health-related quality of life of patients with cystic fibrosis and their carers in France.
abstract: BACKGROUND
  Our goal was to provide data on the economic burden and health-related quality of life (HRQoL) associated with cystic fibrosis (CF) in France.
  
  
  METHODS
  A retrospective cross-sectional study was carried out on adults and children with CF, who completed an anonymous questionnaire regarding their socio-demographic characteristics, healthcare consumption and presence of a carer. Costs were calculated with a bottom-up approach, and HRQoL was assessed using EQ-5D.
  
  
  RESULTS
  82 adults and 158 children were included. The total average annual cost of CF was €29,746 per patient. Total costs were higher in adults than in children and increased with disease duration. The average utility was lower in adults (0.667 vs. 0.783 in children, p=0.0015). The HRQoL of carers was also affected (0.742 and 0.765 for carers of adults and children with CF, respectively).
  
  
  CONCLUSIONS
  Our study highlights the burden of CF in terms of costs and decreased HRQoL for both patients and carers.
authors.affiliation: URC Eco Ile de France, DRCD, Hôtel Dieu, 75004 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, ECEVE, UMRS 1123, 75010 Paris, France; Inserm, ECEVE, U1123, 75010 Paris, France. Electronic address: karine.chevreul@urc-eco.fr.
authors.forename: Karine
authors.initials: K
authors.lastname: Chevreul
authors.affiliation: URC Eco Ile de France, DRCD, Hôtel Dieu, 75004 Paris, France; Université Paris Est, 94010 Créteil, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Berg Brigham
authors.affiliation: URC Eco Ile de France, DRCD, Hôtel Dieu, 75004 Paris, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Michel
authors.affiliation: CRCM de Roscoff, Centre de Perharidy, 29684 Roscoff cedex, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Rault
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000191:economics* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics; D006801:Humans; D008297:Male; D009017:Morbidity / Q000639:trends; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Costs and cost analysis; Cystic fibrosis; Economic burden; Health-related quality of life