title: E-cadherin and α-SMA expression in the epithelial-mesenchymal transition of salivary glands pleomorphic adenomas.
abstract: The pleomorphic adenoma, known also as mixed tumor of epithelioma with reshuffling stroma, is the most frequent salivary gland tumor, representing 45-75% of the total salivary gland tumors. In our study, we have investigated the immunohistochemical expression of E-cadherin and alpha-smooth muscle actin (α-SMA) in 15 cases of pleomorphic adenoma of salivary glands. We noticed the constant presence of E-cadherin reactivity at the level of luminal cells that cover the proliferative structures of ductal-cystic type, which gradually disappears to the periphery. At the level of epithelial proliferative solid areas, the reactivity for E-cadherin was inconstant and heterogeneous, while α-SMA expression increased. This aspect indicated the involving of epithelial-mesenchymal transition process in the evolution of pleomorphic adenoma.
authors.affiliation: Emergency County Hospital of Craiova, Romania; ancaenescus@yahoo.com.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Enescu
authors.forename: Anca Ştefania
authors.initials: AŞ
authors.lastname: Enescu
authors.forename: Charoula
authors.initials: C
authors.lastname: Florou
authors.forename: Florin
authors.initials: F
authors.lastname: Petrescu
mesh_terms: D000199:Actins / Q000378:metabolism*; D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D015820:Cadherins / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D055815:Young Adult
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins