title: Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells.
abstract: OBJECTIVE
  Acute radiation syndrome (ARS) leads to pancytopenia and multi-organ failure. Transplantation of hematopoietic stem cells provides a curative option for radiation-induced aplasia, but this therapy is limited by donor availability.
  
  
  METHODS
  We examined an alternative therapeutic approach to ARS with the use of human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells (UCMSCs). This treatment combines the unique regenerative role of UCMSCs with the anti-oxidative activity of ECSOD.
  
  
  RESULTS
  We demonstrated that systemically administered ECSOD-UCMSCs are able to protect mice from sub-lethal doses of radiation and improve survival by promoting multilineage hematopoietic recovery. The therapeutic effect of this treatment is related to the decrease in radiation-induced O(2)(-) and apoptosis.
  
  
  CONCLUSIONS
  Our data highlight the clinical potential of this two-pronged approach to the treatment of ARS, thereby serving as a rapid and effective first-line strategy to combat the hematopoietic failure resulting from a radiation accident, nuclear terrorism and other radiologic emergencies.
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Gan
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Fanwei
authors.initials: F
authors.lastname: Meng
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Li
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: He
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Xingen
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Zeng
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China.
authors.forename: Muyun
authors.initials: M
authors.lastname: Liu
authors.affiliation: GMR Epigenetics, Palo Alto, California, USA; Department of Pharmacy & Pharmacology, University of Bath, Bath, England.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Mrsny
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China. Electronic address: huxiang@beike.cc.
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, California, USA; GMR Epigenetics, Palo Alto, California, USA. Electronic address: jifan@stanford.edu.
authors.forename: Jifan
authors.initials: J
authors.lastname: Hu
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Yuanxing Science and Technology Building, Nanshan, Shenzhen, China. Electronic address: litao@beike.cc.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D054508:Acute Radiation Syndrome / Q000628:therapy*; D000818:Animals; D017209:Apoptosis; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism*; D014470:Umbilical Cord / Q000166:cytology
chemical_list: D011837:Radiation-Protective Agents; D013482:Superoxide Dismutase
keywords: acute radiation syndrome; apoptosis; hematopoietic failure; stem cell; superoxide dismutase; umbilical cord mesenchymal stromal cells