title: Generally detected genes in comparative transcriptomics in bivalves: toward the identification of molecular markers of cellular stress response.
abstract: The specificity and representativeness of protein-coding genes identified by transcriptomics as biomarkers for environmental toxicological stress is crucial. We extracted the differential gene expression profile data from 49 published comparative transcriptomic studies of bivalves from January 2004 till November 2014 performed in 15 different bivalve species. Among the studies, 77 protein-coding genes were frequently detected when we use threefold of the average detection frequency as cut-off. Cellular organization and communication, protein and energy metabolism, stress response are the main functional classes of these proteins. We consider if these protein-coding genes represent common cellular stress responses of bivalves.
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Miao
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Luping
authors.initials: L
authors.lastname: Chi
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China. Electronic address: panlq@ouc.edu.cn.
authors.forename: Luqing
authors.initials: L
authors.lastname: Pan
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
mesh_terms: D000818:Animals; D015415:Biomarkers; D049872:Bivalvia / Q000187:drug effects / Q000235:genetics*; D004785:Environmental Pollutants / Q000633:toxicity; D063990:Gene Ontology; D019216:Metals, Heavy / Q000633:toxicity; D013312:Stress, Physiological / Q000235:genetics*; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D019216:Metals, Heavy
keywords: Bivalve; Cellular stress response; Detection frequency; Differential expression; Meta-analysis; Transcriptomic