title: Mobile device for disease diagnosis and data tracking in resource-limited settings.
abstract: Here we describe a low-cost mobile device that combines cell-phone and satellite communication technologies with fluid miniaturization techniques for performing all essential functions of enzyme-linked immunosorbent assay (ELISA). Disease-specific antigens are immobilized on the microfluidic surface, and disease specific antibodies are captured on the surface and visualized with silver-gold amplification. The diagnostic result is automatically determined by the device by measuring the absorbance through the silver-gold amplification in the microchannel. The results are displayed for the user and are synchronized to a remote patient record. The overall system aims to be portable, robust, low-power, and fully utilize the ability of mobile devices for bringing better health care to resource poor areas.
authors.affiliation: Department of Biomedical Engineering, Columbia University, 500 West 120th St, 351 Engineering Terrace, New York, NY, 10027, USA.
authors.forename: Tiffany W
authors.initials: TW
authors.lastname: Guo
authors.forename: Tassaneewan
authors.initials: T
authors.lastname: Laksanasopin
authors.forename: Archana A
authors.initials: AA
authors.lastname: Sridhara
authors.forename: Samiksha
authors.initials: S
authors.lastname: Nayak
authors.forename: Samuel K
authors.initials: SK
authors.lastname: Sia
mesh_terms: D000906:Antibodies / Q000737:chemistry; D000941:Antigens / Q000032:analysis*; D020811:Biomedical Technology / Q000191:economics / Q000295:instrumentation* / Q000379:methods; D040421:Cell Phone / Q000191:economics / Q000295:instrumentation; D003906:Developing Countries; D004797:Enzyme-Linked Immunosorbent Assay; D006046:Gold / Q000737:chemistry; D055991:Health Records, Personal; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000191:economics / Q000295:instrumentation*; D017215:Satellite Communications; D012834:Silver / Q000737:chemistry; D017216:Telemedicine / Q000191:economics / Q000295:instrumentation* / Q000379:methods
chemical_list: D000906:Antibodies; D000941:Antigens; D012834:Silver; D006046:Gold