title: Effects of mesenchymal stem cells in renovascular hypertension.
abstract: What is the topic of this review? The major topic of this review addresses the effects of mesenchymal stem cell treatment in renovascular hypertension. What advances does it highlight? This therapy may be a promising strategy to treat renovascular hypertension and its renal consequences in the near future. Renovascular hypertension induced by the two-kidney, one-clip technique is a renin-angiotensin system-dependent model that leads to renal vascular rarefaction, fibrosis and renal failure. Treatment of renovascular hypertension remains a challenge, and thus, new therapies are needed. In this report, we discuss the beneficial effects of mesenchymal stem cells on the reconstruction of the renal parenchyma of the stenotic kidney to improve vascular rarefaction and fibrosis. Mesenchymal stem cell therapy prevented the progressive increase in systolic arterial pressure, reduced sympathetic hyperactivity, improved renal morphology, induced neovascularization and reduced fibrosis in stenotic kidneys. Although this therapy may be a promising strategy to treat renovascular hypertension and its renal consequences, further studies are necessary to improve the efficiency of mesenchymal stem cells.
authors.affiliation: Department of Medicine, Renal Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Department of Physiology, Cardiovascular Division, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Oliveira-Sales
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Varela
authors.forename: Cassia T
authors.initials: CT
authors.lastname: Bergamaschi
authors.forename: Ruy R
authors.initials: RR
authors.lastname: Campos
authors.forename: Mirian A
authors.initials: MA
authors.lastname: Boim
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D006978:Hypertension, Renovascular / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012084:Renin-Angiotensin System / Q000502:physiology*