title: [Relationship between CD4(+) T lymphocyte cell count and the prognosis (including the healing of the incision wound) of HIV/AIDS patients who had undergone surgical operation].
abstract: OBJECTIVE
  To explore the relationship between CD4(+) T lymphocyte cell count and prognosis as well as healing of the surgical incision in HIV/AIDS patients who had received operation.
  
  
  METHODS
  Data were collected and analysed retrospectively from 234 HIV/AIDS patients hospitalized at the Beijing Ditan hospital who underwent operation between January 2008 and December 2012. Following factors were taken into consideration that including:age, gender, time and where that anti-HIV(+) was diagnosed, CD4(+)T lymphocyte cell count at the time of operation, part of the body that being operated, typology of incision, different levels of healing on the surgical incision, infection at the incision site, post-operative complications and the prognosis, etc. Wilcoxon rank sum test, χ(2) test, Kruskal-Wallis H test and Spearman rank correlation were used for statistical analysis to compare the different levels on healing of the incision in relation to the different CD4(+)T lymphocyte cell counts. Rates of level A healing under different CD4(+)T cell counts were also compared.
  
  
  RESULTS
  1) Among the 234 patients including 125 males and 109 females, the average age was 36.17±11.56 years old. Time after discovery of anti-HIV(+)was between 0 and 204 months. The medium CD4(+)T cell count was 388.5 cell/µl; 23.93% of the patients having CD4(+)T lymphocyte cell counts as <200 cell/µl. 2) 7.26% of the operations were emergent. There were 23 different organs affected at the time of operation, due to 48 different kinds of illness. 21.37% of the operations belonged to class I incision, 49.57% was class II incision and 29.06% was class III incision. 86.32% of the incisions resulted in level A healing, 12.51% resulted in level B and 1.71% in level C. 4.27% of the patients developed post-operative complications. Differences between level A healing and level B or C healing in terms of CD4(+)T lymphocyte cell count were not significant (P > 0.05). There was no statistically significant difference on the CD4(+) T lymphocyte count in patients with or without postoperative complications. Difference of the HIV infection time was also not statistically significant between the two groups of patients. Rate of level A healing for the different CD4(+)T lymphocyte cell count was not significant (P > 0.05). Healing of the incision did not show significant correlation with CD4(+) T lymphocyte cell count, duration of antiretroviral therapy or the time that HIV infection was discovered (P > 0.05).
  
  
  CONCLUSIONS
  As long as both the in/exclusion criteria were strictly followed, prognosis for operation on HIV/AIDS seemed to be generally good. Low CD4(+)T lymphocyte cell count should not be taken as a exclusion criteria for operation on HIV/AIDS patients.
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Di
authors.initials: D
authors.lastname: Yang
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. Email: 13911022130@163.com.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. Email: guiju.gao@163.com.
authors.forename: Guiju
authors.initials: G
authors.lastname: Gao
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wei
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Han
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Xiao
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Liang
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: The Infectious Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D003141:Communicable Diseases; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative; D013601:T-Lymphocytes; D014945:Wound Healing; D055815:Young Adult