title: Antiretroviral blood levels in HIV/HCV-coinfected patients with cirrhosis after liver transplant: a report of three cases.
abstract: Since the introduction of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection is no longer a contraindication for solid organ transplantation. In HIV/hepatitis C virus (HCV)-coinfected patients undergoing liver transplantation, HCV-related cirrhosis, drug-drug interactions, and calcineurin inhibitors-related toxicity affect clinical outcomes. Therapeutic drug monitoring can be useful to assess antiretroviral over- or underexposure in this cohort. We report the clinical characteristics along with antiretroviral trough levels of maraviroc, darunavir, and etravirine in 3 HIV/HCV-coinfected liver transplant recipients who developed post-transplant liver cirrhosis.
authors.affiliation: Infectious Diseases Department, Santa Maria della Misericordia University Hospital, Udine, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Righi
authors.forename: A
authors.initials: A
authors.lastname: Londero
authors.forename: F
authors.initials: F
authors.lastname: Pea
authors.forename: S
authors.initials: S
authors.lastname: Bonora
authors.forename: P
authors.initials: P
authors.lastname: Nasta
authors.forename: P
authors.initials: P
authors.lastname: Della Siega
authors.forename: P
authors.initials: P
authors.lastname: Delle Foglie
authors.forename: G
authors.initials: G
authors.lastname: Villa
authors.forename: O
authors.initials: O
authors.lastname: Giglio
authors.forename: S
authors.initials: S
authors.lastname: Dal Zoppo
authors.forename: U
authors.initials: U
authors.lastname: Baccarani
authors.forename: M
authors.initials: M
authors.lastname: Bassetti
mesh_terms: D044966:Anti-Retroviral Agents / Q000097:blood* / Q000493:pharmacokinetics; D060085:Coinfection; D003510:Cyclohexanes / Q000097:blood / Q000493:pharmacokinetics; D000069454:Darunavir / Q000097:blood / Q000493:pharmacokinetics; D016903:Drug Monitoring; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D000077592:Maraviroc; D008875:Middle Aged; D009570:Nitriles; D011724:Pyridazines / Q000097:blood / Q000493:pharmacokinetics; D011743:Pyrimidines; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D044966:Anti-Retroviral Agents; D003510:Cyclohexanes; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D014230:Triazoles; C451734:etravirine; D000077592:Maraviroc; D000069454:Darunavir
keywords: HIV/HCV coinfection; antiretrovirals; c-ART; cirrhosis; liver transplant; therapaeutic drug monitoring