title: [A case of advanced gastric cancer responding to S-1/CDDP neoadjuvant chemotherapy, leading to a pathological complete response].
abstract: A 66-year-old man with cStage III B (cT4aN2H0P0M0) advanced gastric cancer in the cardia with esophageal invasion was treated with S-1/CDDP as neoadjuvant chemotherapy. After 3 courses of chemotherapy, a significant reduction in tumor burden was observed. Total gastrectomy and splenectomy with lymph node dissection (D2) were performed. Pathological specimens showed no cancer cells in the stomach and lymph nodes, indicating a pathological complete response.
authors.affiliation: Dept. of Surgery, Baba Memorial Hospital.
authors.forename: Kishu
authors.initials: K
authors.lastname: Kitayama
authors.forename: Isao
authors.initials: I
authors.lastname: Kanehara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Teraoka
authors.forename: Junya
authors.initials: J
authors.lastname: Nishimura
authors.forename: Shinya
authors.initials: S
authors.lastname: Nomura
authors.forename: Eiji
authors.initials: E
authors.lastname: Noda
authors.forename: Hiroji
authors.initials: H
authors.lastname: Nishino
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin