title: Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients.
abstract: No new acquisition of Clostridium difficile occurred among 12 hospitalised patients receiving tigecycline, and pre-existing colonisation was reduced to undetectable levels in 2 patients. Moreover, 91% of stool suspensions obtained during tigecycline therapy exhibited inhibitory activity against C. difficile. These results suggest that tigecycline achieves sufficient concentrations to inhibit intestinal colonisation by C. difficile.
authors.affiliation: Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Sirisha
authors.initials: S
authors.lastname: Kundrapu
authors.affiliation: Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Hurless
authors.affiliation: Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Venkata C K
authors.initials: VC
authors.lastname: Sunkesula
authors.affiliation: Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Geriatric Research, Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.
authors.forename: Myreen
authors.initials: M
authors.lastname: Tomas
authors.affiliation: Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Geriatric Research, Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA. Electronic address: curtisd123@yahoo.com.
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000382:microbiology* / Q000517:prevention & control*; D015331:Cohort Studies; D005243:Feces / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011446:Prospective Studies; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: Clostridium difficile; Inhibition; Tigecycline