title: Guidelines for translational research in heart failure.
abstract: Heart failure (HF) remains a major cause of death and hospitalization worldwide. Despite medical advances, the prognosis of HF remains poor and new therapeutic approaches are urgently needed. The development of new therapies for HF is hindered by inappropriate or incomplete preclinical studies. In these guidelines, we present a number of recommendations to enhance similarity between HF animal models and the human condition in order to reduce the chances of failure in subsequent clinical trials. We propose different approaches to address safety as well as efficacy of new therapeutic products. We also propose that good practice rules are followed from the outset so that the chances of eventual approval by regulatory agencies increase. We hope that these guidelines will help improve the translation of results from animal models to humans and thereby contribute to more successful clinical trials and development of new therapies for HF.
authors.affiliation: Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernandez Almagro 3, 28029, Madrid, Spain, elara@cnic.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lara-Pezzi
authors.forename: Philippe
authors.initials: P
authors.lastname: Menasché
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Trouvin
authors.forename: Lina
authors.initials: L
authors.lastname: Badimón
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Koch
authors.forename: Albert F
authors.initials: AF
authors.lastname: De Felice
authors.forename: Peter
authors.initials: P
authors.lastname: de Waele
authors.forename: Valérie
authors.initials: V
authors.lastname: Steenwinckel
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hajjar
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Zeiher
mesh_terms: D000818:Animals; D002309:Cardiology / Q000592:standards*; D004195:Disease Models, Animal; D017408:Guidelines as Topic; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D012107:Research Design / Q000592:standards*; D057170:Translational Research, Biomedical / Q000592:standards*