title: Genome editing-based HIV therapies.
abstract: Genome editing (GE)-based HIV therapy is achieved by modification of infection-related genes to produce HIV-resistant cells followed by reinfusion of the modified cells into patients. The ultimate goal is to achieve a functional or actual cure for HIV infection. Despite multiple potential targets for GE-based HIV therapies, CCR5 is the most feasible owing to the naturally existing CCR5 δ32 genotype which confers resistance to HIV. A recent clinical trial of infusion of modified autologous CD4(+) T cells proved safety and efficacy within the limits of the studies. However, long-term evaluation of the safety and efficacy is required before GE-based HIV therapy is ready for clinical implementation.
authors.affiliation: Department of Immunology, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: 25241272@qq.com.
authors.forename: Wan-Gang
authors.initials: WG
authors.lastname: Gu
mesh_terms: D001691:Biological Therapy / Q000009:adverse effects / Q000379:methods*; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D015658:HIV Infections / Q000628:therapy*; D006801:Humans
keywords: AIDS; CCR5; HIV; genome editing; infusion