title: Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter.
abstract: Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylamine-based analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. catharina.neudorfer@gmail.com.
authors.forename: Catharina
authors.initials: C
authors.lastname: Neudorfer
authors.affiliation: Division of Drug Design and Medicinal Chemistry, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. amir.seddik@univie.ac.at.
authors.forename: Amir
authors.initials: A
authors.lastname: Seddik
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. wolfgang.holzer@univie.ac.at.
authors.forename: Karem
authors.initials: K
authors.lastname: Shanab
authors.affiliation: Division of Drug Design and Medicinal Chemistry, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. andreas.jurik@univie.ac.at.
authors.forename: Andreas
authors.initials: A
authors.lastname: Jurik
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Rami-Mark
authors.affiliation: Division of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. wolfgang.holzer@univie.ac.at.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Holzer
authors.affiliation: Division of Drug Design and Medicinal Chemistry, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. gerhard.f.ecker@univie.ac.at.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ecker
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.mitterhauser@meduniwien.ac.at.
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. wolfgang.wadsak@meduniwien.ac.at.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.affiliation: Division of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. helmut.spreitzer@univie.ac.at.
authors.forename: Helmut
authors.initials: H
authors.lastname: Spreitzer
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008024:Ligands; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D012015:Reference Standards; D016415:Sequence Alignment
chemical_list: D008024:Ligands; D050484:Norepinephrine Plasma Membrane Transport Proteins; D019275:Radiopharmaceuticals