title: Effects of Flurbiprofen Axetil on Postoperative Analgesia and Cytokines in Peripheral Blood of Thoracotomy Patients.
abstract: The objective is to study the effects of flurbiprofen axetil (FA) with fentanyl together in postoperative controlled intravenous analgesia (PCIA) on pain intensity, cytokine levels in peripheral blood and adverse reactions of thoracotomy patients. Fifty thoracotomy patients were divided into a FA and a control group, each with 25 cases. Postoperative analgesia was administered in the two groups using PCIA. The pressing times of analgesia pump, the visual analog scale (VAS) scores during resting and coughing at 2, 6, 24, 48, 72 h after surgery and the incidence of adverse drug reactions were recorded. Levels of IL-1β, IL-6, IL-8, IL-2, and TNF-α in peripheral blood were determined before the administration of FA (T0), and at 24 h (T1), 48 h (T2), 72 h (T3) after surgery. The analgesia pump pressing times in the FA group was less than that of the control group. The VAS scores during resting and coughing at 2, 6, 24, 48, 72 h after surgery, were statistically less than those of control group. The incidence rate of nausea and vomiting was insignificantly different between the two groups. Administration of FA together with PCIA in thoracotomy patients can improve postoperative analgesia.
authors.affiliation: Department of Anesthesiology, Xuzhou First People's Hospital, 19 Zhongshan North Road, Xuzhou, 221002, Jiangsu, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, Xuzhou First People's Hospital, 19 Zhongshan North Road, Xuzhou, 221002, Jiangsu, China.
authors.forename: Beiping
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Xuzhou First People's Hospital, 19 Zhongshan North Road, Xuzhou, 221002, Jiangsu, China. contribution061@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Kong
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood*; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010149:Postoperative Pain / Q000188:drug therapy*; D013908:Thoracotomy / Q000009:adverse effects*; D014839:Vomiting / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D005480:Flurbiprofen; C504422:flurbiprofen axetil
keywords: Cytokines; Flurbiprofen axetil; Postoperative analgesia; Thoracotomy patients