title: The Healing Effects of Aquatic Activities and Allogenic Injection of Platelet-Rich Plasma (PRP) on Injuries of Achilles Tendon in Experimental Rat.
abstract: BACKGROUND
  Clinical tendon injuries represent serious and unresolved issues of the case on how the injured tendons could be improved based on natural structure and mechanical strength. The aim of this studies the effect of aquatic activities and alogenic platelet rich plasma (PRP) injection in healing Achilles tendons of rats.
  
  
  METHODS
  Forty rats were randomly divided into 5 equal groups. Seventy two hours after a crush lesion on Achilles tendon, group 1 underwent aquatic activity for 8 weeks (five sessions per week), group 2 received intra-articular PRP (1 ml), group 3 had aquatic activity together with injection PRP injection after an experimental tendon injury, group 4 did not receive any treatment after tendon injury and the control group with no tendon injuries. of 32 rats. After 8 weeks, the animals were sacrificed and the tendons were transferred in 10% formalin for histological evaluation.
  
  
  RESULTS
  There was a significant increase in number of fibroblast and cellular density, and collagen deposition in group 3 comparing to other groups denoting to an effective healing in injured tendons. However, there was no significant difference among the studied groups based on their tendons diameter.
  
  
  CONCLUSIONS
  Based on our findings on the number of fibroblast, cellular density, collagen deposition, and tendon diameter, it was shown that aquatic activity together with PRP injection was the therapeutic measure of choice enhance healing in tendon injuries that can open a window in treatment of damages to tendons.
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmei University, Tehran, Iran;
authors.forename: Hamid
authors.initials: H
authors.lastname: Rajabi
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmei University, Tehran, Iran;
authors.forename: Homa
authors.initials: H
authors.lastname: Sheikhani Shahin
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmei University, Tehran, Iran;
authors.forename: Manijeh
authors.initials: M
authors.lastname: Norouzian
authors.affiliation: Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
authors.affiliation: Department of Veterinary Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Seifollah
authors.initials: S
authors.lastname: Dehghani Nazhvani
keywords: Aquatic activities; Healing; Platelet Rich Plasma; Rat; Tendon