title: Comparison of perinatal outcome in growth restricted fetuses retaining normal umbilical artery Doppler flow to those with diminished end-diastolic flow.
abstract: BACKGROUND
  Intrauterine growth restriction /retardation (IUGR) is defined as birth weight below the 10th percentile for a given gestational age. Placental insufficiency is the primary cause of intrauterine growth retardation in normally formed fetuses and can be identified using umbilical artery Doppler velocimetry which is a non-invasive technique. The objective of this study was to compare perinatal outcome in growth restricted fetuses retaining normal umbilical artery Doppler flow to those with diminished or severely reduced/absent end-diastolic flow.
  
  
  METHODS
  This cross sectional study was conducted at Radiology department of Pakistan Navy Ship (PNS) Shifa Hospital, Karachi over one year period from. Established cases of asymmetrical IUGR, having estimated fetal weight < 10th percentile for gestational age and between 28-40 weeks of gestation were included in the study. Pulsatility index (PI) was calculated for each case. Perinatal outcomes like early delivery, caesarean section, respiratory distress syndrome, necrotizing enterocolitis, admission to neonatal ICU, prenatal and neonatal death were evaluated. Chi-square test was used to compare proportion difference of perinatal outcomes for normal and abnormal umbilical artery velocimetry, with 0.05 level of significance.
  
  
  RESULTS
  Umbilical artery Doppler velocimetry showed a significant correlation with the perinatal outcome. In 90% of cases of IUGR having abnormal waveform, poor perinatal outcome was seen as compared to only 33.3% retaining normal Doppler flow.
  
  
  CONCLUSIONS
  Growth restricted fetuses with normal umbilical artery Doppler velocimetry were at lower risk than those with abnormal waveforms.
authors.affiliation: Department of Radiology, Shaikh Khlifa Bin Zayed Hospital, Muzafarabad, AJK. tariqssr@gmail.com
authors.forename: Tariq Saeed
authors.initials: TS
authors.lastname: Siddiqui
authors.forename: Aisha
authors.initials: A
authors.lastname: Asim
authors.forename: Shafqut
authors.initials: S
authors.lastname: Ali
authors.forename: Tahir Saeed
authors.initials: TS
authors.lastname: Siddiqui
authors.forename: Asima
authors.initials: A
authors.lastname: Tariq
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D011256:Pregnancy Outcome; D011673:Pulsatile Flow / Q000502:physiology; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055815:Young Adult