title: G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
abstract: Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors.
authors.affiliation: From the Departments of Psychiatry and.
authors.forename: Nikoleta G
authors.initials: NG
authors.lastname: Tsvetanova
authors.affiliation: From the Departments of Psychiatry and.
authors.forename: Roshanak
authors.initials: R
authors.lastname: Irannejad
authors.affiliation: From the Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 mark.vonzastrow@ucsf.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: von Zastrow
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods; D000242:Cyclic AMP / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled; D000242:Cyclic AMP; D020962:Heterotrimeric GTP-Binding Proteins
keywords: Cell Signaling; Cyclic AMP (cAMP); Endocytosis; Endosome; G Protein; G Protein-coupled Receptor (GPCR); Protein Sorting; Signal Transduction; Transcription