title: Serum amyloid a truncations in type 2 diabetes mellitus.
abstract: METHODS
  Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes.
  
  
  RESULTS
  The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p<0.001). This ratio was negatively correlated with glycated hemoglobin (r = -0.32, p<0.001) and triglyceride concentrations (r = -0.37, p<0.001), and positively correlated with HDL cholesterol concentrations (r = 0.32, p<0.001).
  
  
  CONCLUSIONS
  The relative abundance of the N-terminal arginine truncation of SAA1.1 is significantly decreased in diabetes and negatively correlates with measures of glycemic and lipid control.
authors.affiliation: University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Hussein N
authors.initials: HN
authors.lastname: Yassine
authors.affiliation: Arizona State University, Tempe, AZ, United States of America.
authors.forename: Olgica
authors.initials: O
authors.lastname: Trenchevska
authors.affiliation: University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Huijuan
authors.initials: H
authors.lastname: He
authors.affiliation: Arizona State University, Tempe, AZ, United States of America.
authors.forename: Chad R
authors.initials: CR
authors.lastname: Borges
authors.affiliation: Arizona State University, Tempe, AZ, United States of America.
authors.forename: Dobrin
authors.initials: D
authors.lastname: Nedelkov
authors.affiliation: University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Wendy
authors.initials: W
authors.lastname: Mack
authors.affiliation: University of Southern California, Los Angeles, CA, United States of America.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kono
authors.affiliation: Phoenix VA Health Care System, Phoenix, AZ, United States of America.
authors.forename: Juraj
authors.initials: J
authors.lastname: Koska
authors.affiliation: Phoenix VA Health Care System, Phoenix, AZ, United States of America.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Reaven
authors.affiliation: Arizona State University, Tempe, AZ, United States of America.
authors.forename: Randall W
authors.initials: RW
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D008076:Cholesterol, HDL; D000685:Serum Amyloid A Protein; D001120:Arginine