title: High compliance vascular grafts based on semi-interpenetrating networks.
abstract: Current synthetic vascular grafts have poor patency rates in small diameter applications (<6 mm) due to intimal hyperplasia arising from a compliance mismatch between the graft and native vasculature. Enormous efforts have focused on improving biomechanical properties; however, polymeric grafts are often constrained by an inverse relationship between burst pressure and compliance. We have developed a new, semi-interpenetrating network (semi-IPN) approach to improve compliance without sacrificing burst pressure. The effects of heat treatment on graft morphology, fiber architecture, and resultant biomechanical properties are presented. In addition, biomechanical properties after equilibration at physiological temperature were investigated in relation to polyurethane microstructure to better predictin vivoperformance. Compliance values as high as 9.2 ± 2.7 %/mmHg x 10-4were observed for the semi-IPN graft while also maintaining high burst pressure, 1780 ± 230 mm Hg. The high compliance of these heat-treated poly(carbonate urethane) (PCU) and semi-IPN grafts is expected to improve long-term patency rates beyond even saphenous vein autografts by preventing intimal hyperplasia. The fundamental structure-property relationships gained from this work may also be utilized to advance biomedical device designs based on thermoplastic polyurethanes.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, TX 77840-3120, USA.
authors.forename: David K
authors.initials: DK
authors.lastname: Dempsey
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, TX 77840-3120, USA.
authors.forename: Roya M
authors.initials: RM
authors.lastname: Nezarati
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, TX 77840-3120, USA.
authors.forename: Calvin E
authors.initials: CE
authors.lastname: Mackey
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, 5033 Emerging Technologies Building, 3120 TAMU, College Station, TX 77840-3120, .
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Cosgriff-Hernandez
keywords: electrospinning; polyurethanes; semi-interpenetrating networks; silicones; small-diameter vascular grafts