title: [Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders].
abstract: OBJECTIVE
  To examine serum 25-hydroxyvitamin D levels in children with autism spectrum disorders (ASD) and to explore the relationship between vitamin D level and ASD.
  
  
  METHODS
  Serum levels of 25-hydroxyvitamin D levels were determined by the HPLC-MS/MS method in 117 children with newly diagnosed ASD and 109 healthy controls. Vitamin D status were classified into normal (>30 ng/mL), insufficiency (10-30ng/mL) and deficiency (<10 ng/mL) according to 25-hydroxyvitamin D levels.
  
  
  RESULTS
  Serum level of 25-hydroxyvitamin D (19±9 ng/mL)in children with ASD was significantly lower than that in healthy controls (36±13 ng/mL; P<0.01). The rate of vitamin D insufficiency plus deficiency in the ASD group was significantly higher than in the control group (89.7% vs 52.3%; P<0.01).
  
  
  CONCLUSIONS
  Vitamin D insufficiency or deficiency is common in children with ASD and might be as one of the environmental or genetic factors for ASD.
authors.affiliation: Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun, China. erkekangfujia@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Ling
authors.initials: L
authors.lastname: Shan
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Feng
authors.forename: Zhi-Da
authors.initials: ZD
authors.lastname: Xu
authors.forename: Fei-Yong
authors.initials: FY
authors.lastname: Jia
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood*; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D