title: Cytotoxic activity and composition of petroleum ether extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae).
abstract: The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.
authors.affiliation: Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Salerno 84084, Italy. autore@unisa.it.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Autore
authors.affiliation: Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Salerno 84084, Italy. marzocco@unisa.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Marzocco
authors.affiliation: Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, Napoli 49 80131, Italy. caformis@unina.it.
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.affiliation: Department STEBICEF, University of Palermo, Viale delle Scienze, Parco d'Orleans II, Palermo 90128, Italy. maurizio.bruno@unipa.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
authors.affiliation: Department STEBICEF, University of Palermo, Viale delle Scienze, Parco d'Orleans II, Palermo 90128, Italy. sergio.rosselli@unipa.it.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.affiliation: Laboratoire des Plantes Extremophiles-Biotechnologic Center Borj-CedriaTechnopark, B.P. 901, Hammam-Lif 2050, Tunisia. meriem_cbbc@yahoo.fr.
authors.forename: Mariem Ben
authors.initials: MB
authors.lastname: Jemia
authors.affiliation: Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano, Napoli 49 80131, Italy. fesenato@unina.it.
authors.forename: Felice
authors.initials: F
authors.lastname: Senatore
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry; D035264:Flowers / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000473:Alkanes; D003374:Coumarins; D010936:Plant Extracts; C030123:coumarin; C004544:naphtha