title: Palladium(0)-catalyzed iminohalogenation of alkenes: synthesis of 2-halomethyl dihydropyrroles and mechanistic insights into the alkyl halide bond formation.
abstract: Although the advances on carbon halide reductive elimination have been made, the alkyl bromide and chloride analogues remain a challenge. Here, a palladium(0)-catalyzed iminohalogenation of γ,δ-unsaturated oxime esters is described, and the use of electron-poor phosphine ligands proved to be crucial to promoting alkyl bromide and chloride reductive elimination. Furthermore, S(N)2-type alkyl bromide and chloride reductive elimination has also been established.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237 (China).
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Longlei
authors.initials: L
authors.lastname: Hou
authors.forename: Mian
authors.initials: M
authors.lastname: Cheng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Su
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tong
keywords: elimination; halogenation; heterocycles; palladium; synthetic methods