title: When uncommon and common coalesce: adult onset Still's disease associated with breast augmentation as part of autoimmune syndrome induced by adjuvants (ASIA).
abstract: Adult onset Still's disease (AOSD) is an uncommon, multisystemic, auto-inflammatory disorder, while breast augmentation is a very common cosmetic procedure. We describe a case in which these two coalesce, AOSD, manifested with pleuritis and pericarditis, developed after breast mammoplasty. The pathogenetic, missing link, behind the development of AOSD following mammoplasty, is thought to be the autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA). We reviewed other cases of AOSD associated with breast mammoplasty published to date and the literature regarding AOSD and ASIA syndrome. The review is followed by a short debate of whether silicone implants should be explanted in similar, future cases.
authors.affiliation: The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.|Department of Internal Medicine T, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Dagan
authors.affiliation: Department of Internal Medicine T, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Kogan
authors.affiliation: The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel. shoenfel@post.tau.ac.il.|Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel. shoenfel@post.tau.ac.il.
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
authors.affiliation: Department of Internal Medicine T, Sheba Medical Center, Tel Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Segal
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects; D015551:Autoimmunity; D019928:Breast Implantation / Q000009:adverse effects*; D000072226:Computed Tomography Angiography; D005260:Female; D006801:Humans; D010493:Pericarditis / Q000000981:diagnostic imaging; D010998:Pleurisy / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography; D016706:Still's Disease, Adult-Onset / Q000150:complications*; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic
keywords: ASIA syndrome; Adjuvants; Autoimmunity; Breast mammoplasty; Silicone implants; Still’s disease