title: Prevention of osteoporosis by oral administration of phytate-removed and deamidated soybean β-conglycinin.
abstract: Phytate-removed and deamidated soybean β-conglycinin (PrDS) prepared by ion-exchange resins was supplemented to be 4% in the diet administered to ovariectomized rats to investigate its preventive effect on osteoporosis. The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein. On the other hand, administration of PrDS restored the calcium absorption rate to the same level as the sham group. Markers of bone resorption, such as serum parathyroid hormone (PTH) and urinary deoxypyridinoline (DPD), increased, and the bone mineral density and breaking stress decreased following ovariectomy. However, PrDS supplementation suppressed the changes caused by the decrease in calcium absorption from the small intestine. Therefore, PrDS supplementation shows promise for the prevention of postmenopausal osteoporosis.
authors.affiliation: Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. makao@brs.nihon-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Akao
authors.affiliation: Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. r.abe0615@gmail.com.
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Abe
authors.affiliation: Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. foodchem@brs.nihon-u.ac.jp.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sato
authors.affiliation: Department of Food Business, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. tanigome.atsuko@nihon-u.ac.jp.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hasegawa-Tanigome
authors.affiliation: Department of Food Science and Nutrition, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo 101-8437, Japan. kumagai@kyoritsu-wu.ac.jp.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kumagai
authors.affiliation: Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan. kumagai@brs.nihon-u.ac.jp.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kumagai
mesh_terms: D065567:Absorption, Physiological / Q000187:drug effects; D000284:Administration, Oral; D000577:Amides / Q000302:isolation & purification*; D000596:Amino Acids / Q000652:urine; D000818:Animals; D052179:Antigens, Plant / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D001696:Biomechanical Phenomena / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005916:Globulins / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D008903:Minerals / Q000378:metabolism; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control* / Q000652:urine; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000097:blood; D010833:Phytic Acid / Q000302:isolation & purification*; D017208:Rats, Wistar; D055314:Seed Storage Proteins / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000577:Amides; D000596:Amino Acids; D052179:Antigens, Plant; D005916:Globulins; D008903:Minerals; D010281:Parathyroid Hormone; D055314:Seed Storage Proteins; D030262:Soybean Proteins; C013894:beta-conglycinin protein, Glycine max; D010833:Phytic Acid; C036020:deoxypyridinoline