title: Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit.
abstract: The subthalamic nucleus-globus pallidus network is a potential source of oscillations in Parkinson's disease, but the mechanism is unknown. In this issue of Neuron, Chu et al. (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory activity after dopamine depletion.
authors.affiliation: Center of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Mastro
authors.affiliation: Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: agittis@cmu.edu.
authors.forename: Aryn H
authors.initials: AH
authors.lastname: Gittis
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D009044:Motor Cortex / Q000378:metabolism*; D009434:Neural Pathways / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000378:metabolism*; D020531:Subthalamic Nucleus / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D004298:Dopamine