title: A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome.
abstract: The new epidemic Middle East Respiratory Syndrome (MERS) is caused by a type of human coronavirus called MERS-CoV which has global fatality rate of about 30%. We are investigating potential antiviral therapeutics against MERS-CoV by using host microRNAs (miRNAs) which may downregulate viral gene expression to quell viral replication. We computationally predicted potential 13 cellular miRNAs from 11 potential hairpin sequences of MERS-CoV genome. Our study provided an interesting hypothesis that those miRNAs, that is, hsa-miR-628-5p, hsa-miR-6804-3p, hsa-miR-4289, hsa-miR-208a-3p, hsa-miR-510-3p, hsa-miR-18a-3p, hsa-miR-329-3p, hsa-miR-548ax, hsa-miR-3934-5p, hsa-miR-4474-5p, hsa-miR-7974, hsa-miR-6865-5p, and hsa-miR-342-3p, would be antiviral therapeutics against MERS-CoV infection.
authors.affiliation: Institute of Biomedical Studies, Baylor University, Waco, TX 76706, USA.
authors.forename: Md Mahmudul
authors.initials: MM
authors.lastname: Hasan
authors.affiliation: BioMedNanoTech, Inc., 500 South University Avenue Suite 319, Little Rock, AR 72205, USA.
authors.forename: Rozina
authors.initials: R
authors.lastname: Akter
authors.affiliation: Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.
authors.forename: Md Shahin
authors.initials: MS
authors.lastname: Ullah
authors.affiliation: Civil Engineering Department, Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh.
authors.forename: Md Jaynul
authors.initials: MJ
authors.lastname: Abedin
authors.affiliation: Environment Science Discipline, Khulna University, Khulna 9208, Bangladesh.
authors.forename: G M Ahsan
authors.initials: GM
authors.lastname: Ullah
authors.affiliation: BioMedNanoTech, Inc., 500 South University Avenue Suite 319, Little Rock, AR 72205, USA.
authors.forename: Md Zakir
authors.identifier: 0000-0003-3679-612X
authors.initials: MZ
authors.lastname: Hossain