title: Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats.
abstract: Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia- induced preeclampsia in pregnant rats without influencing brain development of rat pups.
authors.affiliation: Department of Gynaecology and Obstetrics, the 202 Hospital of People's Liberation Army, Shenyang 110003, Liaoning Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Emergency Medicine, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Gynaecology and Obstetrics, the 202 Hospital of People's Liberation Army, Shenyang 110003, Liaoning Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Gynaecology and Obstetrics, the Second People's Hospital of Tongliao, Tongliao 280000, Inner Mongolia Autonomous Region, China.
authors.forename: Meijing
authors.initials: M
authors.lastname: Ma
keywords: brain; creatinine; folic acid; hyperhomocysteinemia; nervous system; neural regeneration; offspring; preeclampsia; preeclampsia-like symptom; pregnant rats; proteinuria; regeneration