title: Transformation products of antibiotic and cytostatic drugs in the aquatic cycle that result from effluent treatment and abiotic/biotic reactions in the environment: an increasing challenge calling for higher emphasis on measures at the beginning of the pipe.
abstract: Pharmaceuticals may undergo transformation into new products during almost all possible processes along their life-cycle. This could either take place in the natural water environment and/or during water treatment processes. Numerous studies that address the issue of such transformation products (TPs) have been published, describing selected aspects of TPs in the environment and their formation within effluent and water treatment processes. In order to exemplify the number and quality of information published on TPs, we selected 21 active pharmaceutical ingredients from the groups of antibiotics and antineoplastics, and assessed the knowledge about their TPs that has been published until the end of May 2012. The goal of this work was to demonstrate, that the quality of data on pharmaceutical TPs greatly differs in terms of the availability of chemical structures for each TP, rather than to provide an exhaustive database of available TPs. The aim was to point out the challenge going along with so many TPs formed under different treatment and environmental conditions. An extensive review in the form of a table showing the existing data on 158 TPs for 15 compounds, out of 21 investigated, was presented. Numerous TPs are the result of different treatments and environmental processes. However, also numerous different TPs may be formed within only one type of treatment, applied under sometimes even very similar treatment conditions and treatments times. In general, the growing number of elucidated TPs is rationalized by ineffective removal treatments. Our results demonstrate a severe risk of drowning in much unrelated and non-assessable data, both from a scientific and from a technical treatment-related point of view. Therefore, limiting the input of pharmaceuticals into effluents as well as improving their (bio) degradability and elimination behavior, instead of only relying on advanced effluent treatments, is urgently needed. Solutions that focus on this "beginning of the pipe" approach should minimize the adverse effects of parent compounds by reducing and formation of TPs and their entrance into the natural environment.
authors.affiliation: Institute of Sustainable and Environmental Chemistry, Leuphana University of Lüneburg, Scharnhorststrasse 1, D-21335 Lüneburg, Germany; Department of Pharmacology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syrian Arab Republic. Electronic address: tarek.haddad@uni.leuphana.de.
authors.forename: Tarek
authors.initials: T
authors.lastname: Haddad
authors.affiliation: Institute of Sustainable and Environmental Chemistry, Leuphana University of Lüneburg, Scharnhorststrasse 1, D-21335 Lüneburg, Germany. Electronic address: ewelina.baginska@uni.leuphana.de.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Baginska
authors.affiliation: Institute of Sustainable and Environmental Chemistry, Leuphana University of Lüneburg, Scharnhorststrasse 1, D-21335 Lüneburg, Germany. Electronic address: klaus.kuemmerer@uni.leuphana.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Kümmerer
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D054697:Cytostatic Agents / Q000032:analysis* / Q000737:chemistry; D004777:Environment; D004364:Pharmaceutical Preparations / Q000032:analysis; D014865:Waste Disposal, Fluid; D058438:Water Cycle; D018508:Water Purification / Q000379:methods*; D014881:Water Supply
chemical_list: D000900:Anti-Bacterial Agents; D054697:Cytostatic Agents; D004364:Pharmaceutical Preparations
keywords: Analysis; Aquatic environment; Pharmaceutical; Structure elucidation; Transformation product; Water treatment