title: Solitary fibrous tumors of the pleura: a poorly defined malignancy profile.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinical characteristics and factors that influence the long-term outcomes of solitary fibrous tumors of the pleura.
  
  
  METHODS
  We conducted a retrospective study in 2 centers and reviewed 80 patients who underwent surgery between May 1984 and April 2011.
  
  
  RESULTS
  Of the 80 patients (29 male; median age, 60 years [33 to 85 years]), 47 were symptomatic (59%). The tumors originated from the visceral pleura in 62 cases (79%) and from the parietal pleura in 18 cases (22%). The tumors were pedunculated in 66 cases (83%) and sessile in 20 cases (17%). Surgical resection with histologically free margins was accomplished in 76 of 79 patients (93%). The tumors were classified as benign in 51 cases (65%) and as malignant in 28 (35%). The factors that were significantly associated with malignant tumors were the presence of symptoms (p = 0.03), a mean diameter 10 cm or greater (p = 0.0004), fibrous adherences (p = 0.003), pleural effusion (p = 0.003), and a Ki67 10% or greater (p = 0.003). The median follow-up was 69 months (range, 1 to 315). Local recurrence occurred in 3 cases. The overall 5- and 10-year survival rates were 90% and 86%, respectively, and the mean survival time was 255 ± 15 months. There were no differences between the benign and malignant tumors.
  
  
  CONCLUSIONS
  The recurrence rates are low after surgeries for both benign and malignant solitary fibrous tumors of the pleura. However, the factors that are predictive of recurrence have yet to be specified and require additional immunohistochemical and genetic investigations.
authors.affiliation: Department of General Thoracic Surgery, Georges Pompidou European Hospital, Descartes University, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Boddaert
authors.affiliation: Department of General Thoracic Surgery, Pasteur Hospital, Nice Sophia Antipolis University, Nice, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Guiraudet
authors.affiliation: Department of General Thoracic Surgery, Georges Pompidou European Hospital, Descartes University, Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Grand
authors.affiliation: Department of General Thoracic Surgery, Pasteur Hospital, Nice Sophia Antipolis University, Nice, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Venissac
authors.affiliation: Department of General Thoracic Surgery, Georges Pompidou European Hospital, Descartes University, Paris, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Le Pimpec-Barthes
authors.affiliation: Department of General Thoracic Surgery, Pasteur Hospital, Nice Sophia Antipolis University, Nice, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Mouroux
authors.affiliation: Department of General Thoracic Surgery, Georges Pompidou European Hospital, Descartes University, Paris, France. Electronic address: marc.riquet@egp.aphp.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Riquet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D054363:Solitary Fibrous Tumor, Pleural / Q000175:diagnosis* / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome