title: [Fatal neutropenic enterocolitis in a patient with castration-resistant prostate cancer treated with first-line chemotherapy].
abstract: Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy. The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are heterogeneous. Clinical presentation includes neutropenia, fever and abdominal pain. Treatment is not clearly defined. We present a fatal case of NE in a patient with prostate cancer treated with first-line chemotherapy, docetaxel 75 mg/m2 every three weeks and prednisolone 5 mg × 2 daily. The post-mortem examination confirmed NE with prostate cancer cells in bowel wall.
authors.affiliation: Vesterbrogade 51, 4. tv., 1620 København V. per.kongsted@regionh.dk.
authors.forename: Per
authors.initials: P
authors.lastname: Kongsted
authors.forename: Kiran
authors.initials: K
authors.lastname: Sheikh
authors.forename: Lene Sonne
authors.initials: LS
authors.lastname: Mouritsen
authors.forename: Henriette
authors.initials: H
authors.lastname: Lindberg
authors.forename: Lisa
authors.initials: L
authors.lastname: Sengeløv
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077143:Docetaxel; D044504:Enterocolitis, Neutropenic / Q000139:chemically induced*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel