title: Noninvasive diagnosis and therapeutic effect evaluation of deep vein thrombosis in clinics by near-infrared spectroscopy.
abstract: Deep vein thrombosis (DVT) has become a severe disease with a rising incidence rate. The conventional diagnosis relies on complicated imaging modalities that may also involve invasive contrast agent injection and ionizing procedures (e.g., venography). Noninvasive near-infrared spectroscopy (NIRS) methods have been explored which required the DVT patients to follow some exercise protocols. Here, we attempt to use portable NIRS under patients' natural state for DVT diagnosis. Nine DVT patients and seven healthy subjects participated in NIRS measurements of concentration of oxy- and deoxy-hemoglobins (Δ[HbO2] and Δ[Hb]) relative to data on a tissue mimicking phantom at six particular sites of calves. It was found that Δ[HbO2] is significantly lower in DVT patients than healthy ones, whereas Δ[Hb] is distinctly higher. Moreover, after thrombolytic therapy, both Δ[HbO2] and Δ[Hb] in DVT calves assume a gradual convergence to the curves of healthy ones. This reveals the potential of NIRS for the noninvasive, continuous, and straightforward monitoring/therapeutic effect evaluation of DVT in clinics with appropriate bedside monitoring capability.
authors.affiliation: University of Electronic Science and Technology of China, State Key Lab of Electronic Thin Films and Integrated Devices, Biomedical Engineering Department, Sec.2, No.4 Jianshe north road, Chengdu 610054, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: University of Electronic Science and Technology of China, State Key Lab of Electronic Thin Films and Integrated Devices, Biomedical Engineering Department, Sec.2, No.4 Jianshe north road, Chengdu 610054, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Sun
authors.affiliation: University of Electronic Science and Technology of China, State Key Lab of Electronic Thin Films and Integrated Devices, Biomedical Engineering Department, Sec.2, No.4 Jianshe north road, Chengdu 610054, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: University of Electronic Science and Technology of China, State Key Lab of Electronic Thin Films and Integrated Devices, Biomedical Engineering Department, Sec.2, No.4 Jianshe north road, Chengdu 610054, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Xinhua Hospital, Department of Anesthesiology and Surgical Intensive Care Unit, 1665 Kongjiang road, Shanghai 200092, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Ren
mesh_terms: D000368:Aged; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000503:physiopathology; D008875:Middle Aged; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D015912:Thrombolytic Therapy; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*
chemical_list: D006454:Hemoglobins