title: Increased interhemispheric functional connectivity in college students with non-clinical depressive symptoms in resting state.
abstract: The underlying neural basis of non-clinical depressive symptoms (nCDSs) remains unclear. Interhemispheric functional connectivity has been suggested as one of the most robust characteristics of brain's intrinsic functional architecture. Here, we investigated the functional connectivity between homotopic points in the brain using the voxel-mirrored homotopic connectivity (VMHC) approach. We performed VMHC analysis on resting-state functional magnetic resonance imaging (rs-fMRI) data from 17 individuals with nCDSs and 20 healthy controls (HCs) who were enrolled from a sample of 1105 college students. We found increased VMHCs in the bilateral posterior cerebellum and fusiform gyrus in nCDSs subjects compared with HCs. Furthermore, receiver operating characteristic (ROC) curves indicated that VMHC values in the posterior cerebellum lobes could use to differente nCDSs from HCs [area under the curve (AUC), 0.756; p<0.01]. We suggest increased VMHCs indicate a possible compensatory mechanism involved in the pathophysiology of nCDSs. VMHC values of the posterior cerebellum lobes might serve as a reliable biomarker for identifying nCDSs.
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Wei
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Ji-Liang
authors.initials: JL
authors.lastname: Ren
authors.affiliation: Faculty of Health Management, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Rui-Meng
authors.initials: RM
authors.lastname: Yang
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Guo
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong 518055, China.
authors.forename: Shao-De
authors.initials: SD
authors.lastname: Yu
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Lai
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong 518055, China.
authors.forename: Yao-Qin
authors.initials: YQ
authors.lastname: Xie
authors.affiliation: Department of Radiology, Guangzhou first Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China. Electronic address: weixinhua.hy@gmail.com.
authors.forename: Xin-Qing
authors.initials: XQ
authors.lastname: Jiang
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002531:Cerebellum / Q000503:physiopathology; D003863:Depression / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012372:ROC Curve; D012146:Rest; D055815:Young Adult
keywords: Depressive; Functional connectivity; Magnetic resonance imaging; Physiopathology; Symptoms; Voxel-mirrored homotopic connectivity; Young adult