title: The goiter of a newborn from a mother with Graves´ disease.
abstract: BACKGROUND
  Congenital goiter is a rare condition which can be associated with both fetal hyper- and hypothyroidism. It may result from different situations in maternal-fetal thyroid function because antithyroid medication, iodine as well as stimulatory and inhibitory antibodies readily cross the placenta. Aim of the study is the presentation of a newborn infant with congenital goiter and neonatal thyroid suppression that could be attributed to either an in utero exposure to antithyroid drug - propylthiouracil (PTU) or mother´s blocking antibodies.
  
  
  METHODS
  Full term neonate was born with enlarged thyroid and signs (laboratory findings) of congenital hypothyroidism. The mother was treated due to hyperthyroidism between 8 and 12 week of pregnancy and presented thyroid-stimulating immunoglobulins (TSI) after delivery. During the treatment with replacement doses of L-thyroxin in infancy period no thyroid antibodies in the child were detected.
  
  
  CONCLUSIONS
  The most probable reason was the negative influence of PTU: very high thyroid stimulating hormone (TSH) level since delivery and goiter development indicate that fetal hypothyroidism had been developing for a long time.
authors.forename: Anna
authors.initials: A
authors.lastname: Rakuś-Kwiatosz
authors.forename: Beata
authors.initials: B
authors.lastname: Dorosz-Hreńczuk
authors.forename: Iwona
authors.initials: I
authors.lastname: Beń-Skowronek
mesh_terms: D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006042:Goiter / Q000151:congenital*; D006111:Graves Disease / Q000151:congenital; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000008:administration & dosage*; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D018828:Immunoglobulins, Thyroid-Stimulating; C094372:thyrotropin-binding inhibitory immunoglobulin