title: Frequence, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumors.
abstract: Currently available data on prognostic implication of additional neoplasms in GIST miss comprehensive information on patient outcome with regard to overall or disease specific and disease free survival. Registry data of GIST patients with and without additional neoplasm were compared in retrospective case series. We investigated a total of 836 patients from the multi-center Ulmer GIST registry. Additionally, a second cohort encompassing 143 consecutively recruited patients of a single oncology center were analyzed. The frequency of additional malignant neoplasms in GIST patients was 31.9% and 42.0% in both cohorts with a mean follow-up time of 54 and 65 months (median 48 and 60 months), respectively. The spectrum of additional neoplasms in both cohorts encompasses gastrointestinal tumors (43.5%), uro-genital and breast cancers (34.1%), hematological malignancies (7.3%), skin cancer (7.3%) and others. Additional neoplasms have had a significant impact on patient outcome. The five year overall survival in GIST with additional malignant neoplasms (n = 267) was 62.8% compared to 83.4% in patients without other tumors (n = 569) (P < .001, HR=0.397, 95% CI: 0.298-0.530). Five-year disease specific survival was not different between both groups (90.8% versus 90.9%). 34.2% of all deaths (n = 66 of n = 193) were GIST-related. The presented data suggest a close association between the duration of follow-up and the rate of additional malignancies in GIST patients. Moreover the data indicate a strong impact of additional malignant neoplasms in GIST on patient outcome. A comprehensive follow-up strategy of GIST patients appears to be warranted.
authors.affiliation: Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm Germany. Electronic address: klaus.kramer@uniklinik-ulm.de.
authors.forename: K
authors.initials: K
authors.lastname: Kramer
authors.affiliation: Department of Surgery, District-Hospital St. Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland. Electronic address: sebe_wolf@yahoo.de.
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.affiliation: Institute of Epidemiology and Medical Biometry, Schwabstr. 13, University of Ulm, 89075 Ulm, Germany. Electronic address: benjamin.mayer@uni-ulm.de.
authors.forename: B
authors.initials: B
authors.lastname: Mayer
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany. Electronic address: stefan.schmidt@uniklinik-ulm.de.
authors.forename: S A
authors.initials: SA
authors.lastname: Schmidt
authors.affiliation: Institute of Pathology, University of Erlangen, Krankenhausstr. 8-10, 91054 Erlangen Germany. Electronic address: abbas.agaimy@uk-erlangen.de.
authors.forename: A
authors.initials: A
authors.lastname: Agaimy
authors.affiliation: Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm Germany. Electronic address: doris.henne-bruns@uniklinik-ulm.de.
authors.forename: D
authors.initials: D
authors.lastname: Henne-Bruns
authors.affiliation: Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm Germany. Electronic address: uwe.knippschild@uniklinik-ulm.de.
authors.forename: U
authors.initials: U
authors.lastname: Knippschild
authors.affiliation: Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstraße 112, 70376 Stuttgart, Germany; Department of Clinical Pharmacology, University Hospital, Wilhelmstraße 56, 72074 Tübingen, Germany. Electronic address: matthias.schwab@ikp-stuttgart.de.
authors.forename: M
authors.initials: M
authors.lastname: Schwab
authors.affiliation: Department of Internal Medicine, Alb-Fils-Kliniken, Eichertstr. 3, 73035 Goeppingen, Germany. Electronic address: GISTUlm@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Schmieder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology* / Q000473:pathology; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012042:Registries; D016019:Survival Analysis; D055815:Young Adult