title: Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio.
abstract: Limited data exist on exposures of young children to polycyclic aromatic hydrocarbons (PAHs) in the United States (US). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHPyr), is widely used as a biomarker of total PAH exposure. Our objectives were to quantify urinary 1-OHPyr levels in 126 preschool children over a 48-h period and to examine associations between selected sociodemographic/lifestyle factors and urinary 1-OHPyr levels. Monitoring was performed at 126 homes and 16 daycares in Ohio in 2001, and questionnaires and urine samples were collected. The median urinary 1-OHPyr level was 0.33 ng/mL. In a multiple regression model, sampling season (p = 0.0001) and natural log (ln)-transformed creatinine concentration (p = 0.0006) were highly significant predictors of ln-transformed 1-OH-Pyr concentration; cooking appliance type (p = 0.096) was a marginally significant predictor of ln(1-OHPyr). These children had higher median urinary 1-OHPyr levels compared to other US children (≤ 0.15 ng/mL) in previously published studies, which suggests possible geographical differences in PAH exposure.
authors.affiliation: a US EPA's National Exposure Research Laboratory , Research Triangle Park , NC , United States.
authors.forename: Marsha K
authors.initials: MK
authors.lastname: Morgan
authors.affiliation: a US EPA's National Exposure Research Laboratory , Research Triangle Park , NC , United States.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Jones
authors.affiliation: a US EPA's National Exposure Research Laboratory , Research Triangle Park , NC , United States.
authors.forename: Jon R
authors.initials: JR
authors.lastname: Sobus
authors.affiliation: b Battelle , Columbus , OH , USA.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Chuang
authors.affiliation: c Battelle , Durham , NC , USA.
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Wilson
mesh_terms: D015415:Biomarkers / Q000652:urine; D002675:Child, Preschool; D015331:Cohort Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D015999:Multivariate Analysis; D009820:Ohio; D011721:Pyrenes / Q000652:urine*; D012959:Socioeconomic Factors
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D011721:Pyrenes; C033146:1-hydroxypyrene
keywords: 1-hydroxypyrene; Ohio; biomarker; exposure; pyrene