title: Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis.
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK. michael.hughes-6@postgrad.manchester.ac.uk.
authors.forename: Michael
authors.initials: M
authors.lastname: Hughes
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK. Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
authors.forename: Garth J S
authors.initials: GJ
authors.lastname: Cooper
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
authors.forename: Jack
authors.initials: J
authors.lastname: Wilkinson
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: New
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
authors.forename: John M
authors.initials: JM
authors.lastname: Guy
authors.affiliation: Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, Research and Development, Rheumatology Directorate and Department of Clinical Biochemistry, Salford Royal NHS Foundation Trust, Salford, UK.
authors.forename: Ariane L
authors.initials: AL
authors.lastname: Herrick
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003300:Copper / Q000378:metabolism*; D005260:Female; D005355:Fibrosis / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism*; D012709:Serum Albumin
chemical_list: D012709:Serum Albumin; D003300:Copper; D012643:Selenium