title: [Sonothrombolysis for acute ischemic stroke].
abstract: BACKGROUND
  Sonothrombolysis (ST) is an emerging modality for the treatment of stroke.
  
  
  OBJECTIVE
  To assess the feasibility to perform ST in a Chilean hospital.
  
  
  METHODS
  Patients attended at a private clinic with an acute ischemic stroke, between September 2002 and May 2013 and eligible for endovenous thrombolysis, were studied with a transcranial Doppler (Spencer PMD 100 or 150®). Those with an adequate sonographic window and a demonstrated arterial occlusion were monitored continuously with transcranial Doppler at the site of worst residual flow following the CLOTBUST study protocol.
  
  
  RESULTS
  One thousand twenty six patients were studied, of whom 136 received intravenous thrombolysis (rt-PA) and 61, aged 66 ± 18 years (59% males), were subjected to ST (7% of total). Their median National Institutes of Health Stroke Scale score was 14, the lapse from symptom onset to rt-PA was 127 minutes (43-223). Middle cerebral artery (MCA) occlusion was found in 88.5% of patients. Complete recanalization was achieved in 44.3% of patients. Sixty percent had Modified Rankin Scale of 0 to 2 at 3 months (95% confidence intervals (CI) 48.1 to 72). Case fatality was 9.8% and asymptomatic intracranial hemorrhage occurred in 9.8% (95% CI: 4.3 to 20.2).
  
  
  CONCLUSIONS
  ST can be carried out in a complex medical center and is safe.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Brunser
authors.forename: Arnold
authors.initials: A
authors.lastname: Hoppe
authors.forename: Paula
authors.initials: P
authors.lastname: Muñoz
authors.forename: Daniel
authors.initials: D
authors.lastname: Cárcamo
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Lavados
authors.forename: Javier
authors.initials: J
authors.lastname: Gaete
authors.forename: Andrés
authors.initials: A
authors.lastname: Roldán
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Rivas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging* / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000295:instrumentation / Q000379:methods*; D014464:Ultrasonic Therapy / Q000379:methods*; D017585:Ultrasonography, Doppler, Transcranial