title: Predictive utility of the changes in matrix metalloproteinase-2 in the early phase for left ventricular reverse remodeling after an acute myocardial infarction.
abstract: BACKGROUND
  The relationship between the serum levels of matrix metalloproteinase (MMP) and tissue inhibitors of MMP (TIMP) and left ventricular (LV) reverse remodeling (LV-RR) after an acute myocardial infarction (AMI) has not been sufficiently examined.
  
  
  RESULTS
  In 25 patients with successful reperfusion after an AMI and 15 normal control subjects, the serum MMP-2 and TIMP-2 levels were measured on days 1, 2, 3, and 7 and at 1 and 6 months after the AMI onset. LV-RR was defined as a >15% decrease in the LV end-systolic volume index at 6 months after the AMI. The MMP-2 level on day 1 and TIMP-2 levels throughout the study period were comparable between the patients with and without LV-RR. The MMP-2 on day 7 (P<0.05) and the changes in the MMP-2 from day 1 to day 7 (∆MMP-2; P<0.01) were lower in patients with than in those without LV-RR. The ∆MMP-2 was strongly correlated with the changes in the LV volume and ejection fraction from 1 month to 6 months after the AMI. The ∆MMP-2 value of <-158.5 ng/mL predicted LV-RR with a high accuracy (91.7% sensitivity and 76.9% specificity; area under the curve=0.82).
  
  
  CONCLUSIONS
  Changes in MMP-2 are associated with LV-RR after an AMI. The ΔMMP-2 might be a useful predictor of subsequent LV-RR.
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Morishita
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Uzui
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Mitsuke
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Kenichi
authors.initials: K
authors.lastname: Arakawa
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Naoki
authors.initials: N
authors.lastname: Amaya
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kaseno
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ishida
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Reiko
authors.initials: R
authors.lastname: Nakaya
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Lee
authors.affiliation: Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Matsuokashimoaizuki, Japan (T.M., H.U., Y.M., K.A., N.A., K.K., K.I., R.N., J.D.L., H.T.).
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tada
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D015996:Survival Rate; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2
keywords: acute myocardial infarction; metalloproteinase; remodeling