title: [Association between apolipoprotein A1-75 bp gene polymorphisms and risk for dyslipidemia and coronary artery disease].
abstract: OBJECTIVE
  To explore the relationship between the apolipoprotein ApoA1-75 bp polymorphism and risk for dyslipidemia and coronary artery disease (CAD).
  
  
  METHODS
  A total of 723 patients (mean age (62.4 ± 10.2) years old) admitted to Guangdong General Hospital from 2011 to 2013 were enrolled. They were subdivided into CAD group (n = 444) and non-CAD (n = 279) group according to the result of coronary angiography (CAG). Clinical data including the profiles of lipids, -75 bp gene polymorphisms and Gensini scores were analyzed to determine the correlation between -75 bp gene polymorphisms, lipid profile and CAD.
  
  
  RESULTS
  Frequency of male gender, history of diabetes and smoking, TC, TG, LDL-C and ApoB level were significantly higher and HDL-C level was significantly lower in CAD group than in non-CAD group (all P < 0.05). Frequency of A allele was significantly lower in CAD group than in non-CAD group (43.7% (194/444) vs. 56.6% (158/279) , P = 0.003). The ApoA1-75 bp gene polymorphism was significantly correlated with CAD (P < 0.005). Multivariate logistic regression analysis showed that -75 bp gene polymorphism mutation (OR = 0.649, P = 0.021) is an independent protective factor for coronary heart disease.
  
  
  CONCLUSIONS
  ApoA1-75 bp gene polymorphism is linked with risk of dyslipidemia and CAD.
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China.
authors.forename: Xuebiao
authors.initials: X
authors.lastname: Wei
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China.
authors.forename: Yaowang
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Yang
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lian
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China.
authors.forename: Jiyan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510080, China. Email: gdydq@medmail.com.cn.
authors.forename: Danqing
authors.initials: D
authors.lastname: Yu
mesh_terms: D000368:Aged; D000483:Alleles; D016632:Apolipoprotein A-I / Q000235:genetics*; D001055:Apolipoproteins B; D003324:Coronary Artery Disease / Q000235:genetics*; D003327:Coronary Disease; D003920:Diabetes Mellitus; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008055:Lipids