title: The -A2518G polymorphism in the MCP-1 gene and inflammatory bowel disease risk: A meta-analysis.
abstract: OBJECTIVE
  The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G polymorphism and the risk of IBD.
  
  
  METHODS
  PubMed, EMBASE and MEDLINE were searched for studies assessing the relationship between the -A2518G polymorphism in MCP-1 gene and the risk of IBD. Available data were extracted and statistically analyzed using STATA 12.0.
  
  
  RESULTS
  A total of five publications involving 3137 individuals (1818 IBD cases and 1319 controls) were included in the meta-analysis. A combined analysis revealed that the MCP-1 -A2518G polymorphism in was a protective factor for GG + AG vs AA (OR 0.76, 95% CI 0.67-0.87, P = 0.000). Subgroup analysis by ethnicity showed that among European patients the AG + GG homozygote, unlike the AA homozygote, had a protective effect against IBD (OR 0.73, 95% CI 0.63-0.84, P = 0.000), but did not do so among Asian and African patients. Subgroup analysis by disease subtype suggested the -A2518G polymorphism in MCP-1 had a protective effect against Crohn's disease (OR 0.69, 95% CI 0.58-0.81, P = 0.000), but not against ulcerative colitis.
  
  
  CONCLUSIONS
  Our meta-analysis suggested that the -A2518G polymorphism in MCP-1 may be a protective factor for IBD in European populations. Further studies are required to confirm these findings.
authors.affiliation: Division of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Yu Wen
authors.initials: YW
authors.lastname: Li
authors.forename: Ci Qiu
authors.initials: CQ
authors.lastname: Yang
authors.forename: Ying Lian
authors.initials: YL
authors.lastname: Xiao
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Chen Xi
authors.initials: CX
authors.lastname: Xie
authors.forename: Sheng Hong
authors.initials: SH
authors.lastname: Zhang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Yu
authors.forename: Hui Ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Wei Ming
authors.initials: WM
authors.lastname: Lu
authors.forename: Min Hu
authors.initials: MH
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: inflammatory bowel disease; meta-analysis; monocyte chemoattractant protein-1; polymorphism; susceptibility