title: Artery buckling affects the mechanical stress in atherosclerotic plaques.
abstract: BACKGROUND
  Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque.
  
  
  METHODS
  Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature.
  
  
  RESULTS
  Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque.
  
  
  CONCLUSIONS
  Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.
authors.forename: Arnav
authors.initials: A
authors.lastname: Sanyal
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Han
mesh_terms: D016880:Anisotropy; D003331:Coronary Vessels / Q000503:physiopathology*; D020342:Finite Element Analysis; D006801:Humans; D017711:Nonlinear Dynamics; D058226:Plaque, Atherosclerotic / Q000503:physiopathology*; D011312:Pressure; D013314:Stress, Mechanical