title: Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population.
abstract: Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide polymorphisms (SNPs) and the development, prostate volume, and international prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (Asp106Asp)] were genotyped and analyzed using multiple logistic regression models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)= 1.90, 95% confidence interval (CI)= 1.07-3.41, P= 0.03] and genotype frequencies (in dominant model, OR= 1.94, 95% CI= 1.01-3.74, P= 0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR= 1.94, 95% CI= 1.01-3.74, P= 0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contribute to the disease severity of BPH.
authors.affiliation: Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hosik
authors.initials: H
authors.lastname: Seok
authors.affiliation: Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Urology, Collage of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Koo Han
authors.initials: KH
authors.lastname: Yoo
authors.affiliation: Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Byung-Cheol
authors.initials: BC
authors.lastname: Lee
authors.affiliation: Herbal Crop Utilization Research Team, Department of Medicinal Crop Research Institute, National Institute of Horticulture & Herbal Science, Rural Administration, Eumseong, Korea.
authors.forename: Young Ock
authors.initials: YO
authors.lastname: Kim
authors.affiliation: Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
keywords: BID; BPH; Prostate volume; Single nucleotide polymorphism