title: Vitamin D Status, Receptor Gene Polymorphisms, and Supplementation on Tuberculosis: A Systematic Review of Case-Control Studies and Randomized Controlled Trials.
abstract: OBJECTIVE
  To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB).
  
  
  METHODS
  We conducted a systematic review of published studies pertaining to case-control and randomized-control trials from 2002 to 2014 using the PubMed database.
  
  
  CONCLUSIONS
  Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.
authors.affiliation: Boston University School of Medicine, Boston MA 02118 USA.
authors.forename: Nilay
authors.initials: N
authors.lastname: Sutaria
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston MA 02118 USA.
authors.forename: Ching-Ti
authors.initials: CT
authors.lastname: Liu
authors.affiliation: Clinical Translational Science Institute, and Department of Medicine, Boston University School of Medicine, Boston MA 02118 USA.
authors.forename: Tai C
authors.initials: TC
authors.lastname: Chen
keywords: Clinical Trials; Polymorphism; Supplementation; Tuberculosis; Vitamin D; Vitamin D Receptor