title: 1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain.
abstract: Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed spectroscopic analysis. This is the first report of 1,19-seco-AVE analogues. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University , 325 Guo-He Road, Shanghai 200433, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: Qunfei
authors.initials: Q
authors.lastname: Zhao
authors.forename: Zhuhua
authors.initials: Z
authors.lastname: Wu
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009154:Mutation; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics*
chemical_list: C000600373:1,19-seco-avermectin; D000970:Antineoplastic Agents; D007559:Ivermectin; C019264:avermectin