title: Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis.
abstract: BACKGROUND
  Cardiovascular morbidity and mortality have been demonstrated to be greater in psoriasis patients than in the general population. Our study aimed to assess the 10-year cardiovascular risk in patients with moderate to severe psoriasis compared with those suffering from other dermatological diseases, using the calibrated Framingham risk score and the Systematic Coronary Risk Evaluation (SCORE) risk charts.
  
  
  METHODS
  A cross-sectional, multicentre study was made of 477 patients, of whom 238 had moderate to severe psoriasis (cases) and 239 were diagnosed with another dermatological disease (controls).
  
  
  RESULTS
  The proportion of patients with intermediate to high 10-year cardiovascular risk using the Framingham equation was significantly higher among psoriasis patients (38.5%; 80/208) than among the controls with other dermatological diseases (23.4%; 50/214, P<.05). No significant differences were observed between the 2 groups with respect to cardiovascular risk using the SCORE risk charts (P=.591). The case group included a greater proportion of obese and morbidly obese patients, as well as patients with higher triglyceride and low density lipoprotein cholesterol levels (P<.05); while high density lipoprotein cholesterol levels were significantly more favorable in patients in the control group (P<.05).
  
  
  CONCLUSIONS
  Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.
authors.forename: Hector
authors.initials: H
authors.lastname: Fernández-Llaca
authors.forename: Pablo
authors.initials: P
authors.lastname: de la Cueva
authors.forename: Jesús
authors.initials: J
authors.lastname: Luelmo
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Armario-Hita
authors.forename: Luz
authors.initials: L
authors.lastname: Samaniego
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Calvo
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D009767:Obesity, Morbid / Q000453:epidemiology; D011565:Psoriasis / Q000150:complications* / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000453:epidemiology*
chemical_list: D008055:Lipids