title: Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult.
abstract: OBJECTIVE
  To evaluate the efficacy of single dose Azithromycin (1 gram) in treatment of cholera in adults. A randomized, controlled clinical trial on 120 adults with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin (1 gram) single dose and Norfloxacin (400 mg) twice daily for three days in treating cholera. Data were analysed for 64 patients who were stool culture positive for Vibrio cholerae. In conjunction with rehydration therapy, 32 patients received Azithromycin and 32 patients received Norfloxacin. Patients in the two treatment groups had comparable clinical characteristics on admission.
  
  
  CONCLUSIONS
  Result shows Azithromycin and Norfloxacin has got almost similar efficacy in reducing stool output, duration of diarrhoea and fluid requirement in cholera positive cases.
authors.affiliation: National Institute of Cholera & Enteric Disease, Kolkata, India;
authors.forename: M K
authors.initials: MK
authors.lastname: Bhattacharya
authors.affiliation: National Institute of Cholera & Enteric Disease, Kolkata, India;
authors.forename: S
authors.initials: S
authors.lastname: Kanungo
authors.affiliation: National Institute of Cholera & Enteric Disease, Kolkata, India;
authors.forename: T
authors.initials: T
authors.lastname: Ramamurthy
authors.affiliation: National Institute of Cholera & Enteric Disease, Kolkata, India;
authors.forename: K
authors.initials: K
authors.lastname: Rajendran
authors.affiliation: ID & BG Hospital, Kolkata, India;
authors.forename: A
authors.initials: A
authors.lastname: Sinha
authors.affiliation: ID & BG Hospital, Kolkata, India;
authors.forename: A
authors.initials: A
authors.lastname: Bhattacharya
authors.affiliation: Bankura Sammilani Medical College, India.
authors.forename: B Sharma
authors.initials: BS
authors.lastname: Sarkar
keywords: Adult cholera; Single dose Azithromycin; Standard Norfloxacin