title: Mitochondrial quality control: Easy come, easy go.
abstract: "Friends come and go but enemies accumulate." - Arthur Bloch Mitochondrial networks in eukaryotic cells are maintained via regular cycles of degradation and biogenesis. These complex processes function in concert with one another to eliminate dysfunctional mitochondria in a specific and targeted manner and coordinate the biogenesis of new organelles. This review covers the two aspects of mitochondrial turnover, focusing on the main pathways and mechanisms involved. The review also summarizes the current methods and techniques for analyzing mitochondrial turnover in vivo and in vitro, from the whole animal proteome level to the level of single organelle.
authors.affiliation: Cedars-Sinai Heart Institute, United States.
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Stotland
authors.affiliation: Cedars-Sinai Heart Institute, United States. Electronic address: Roberta.Gottlieb@cshs.org.
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Gottlieb
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D063154:Mitochondrial Dynamics; D063306:Mitophagy
keywords: Autophagy; Cardiac; Mitochondria; Mitochondrial biogenesis; Mitophagy