title: [Mecanisms of pharmacokinetic interactions involving oral anticancer agents].
abstract: Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France. Electronic address: dominique.leveque@chru-strasbourg.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Levêque
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Duval
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Poulat
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Palas
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Anne
authors.initials: A
authors.lastname: El Aatmani
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Dory
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Becker
authors.affiliation: Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Gourieux
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D018565:Food-Drug Interactions / Q000502:physiology; D065569:Gastrointestinal Absorption / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors
keywords: Agents anticancéreux oraux; Drug interaction; Interaction médicamenteuses; Oral anticancer agents; Pharmacocinétique; Pharmacokinetics