title: Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.
abstract: Quinofuracins A-E, novel anthraquinone derivatives containing β-D-galactofuranose that were isolated from the fungus Staphylotrichum boninense PF1444, induced p53-dependent cell death in human tumor cells. The structures of quinofuracins A-E, including absolute configurations, were elucidated by extensive spectroscopic analysis and chemical transformation studies. Quinofuracins were classified into three groups according to the aglycone moieties. 5'-Oxoaverantin was present in quinofuracins A-C, whereas averantin and versicolorin B were identified in quinofuracins D and E, respectively. These quinofuracins induced p53-dependent growth suppression in human glioblastoma LNZTA3 cells.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Numazu , 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tatsuda
authors.forename: Isao
authors.initials: I
authors.lastname: Momose
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kubota
authors.forename: Masatomi
authors.initials: M
authors.lastname: Iijima
authors.forename: Takao
authors.initials: T
authors.lastname: Kunisada
authors.forename: Takumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
authors.forename: Akio
authors.initials: A
authors.lastname: Nomoto
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000378:metabolism*
chemical_list: C481651:5'-oxoaverantin; D000880:Anthraquinones; D000970:Antineoplastic Agents; D016159:Tumor Suppressor Protein p53; C029827:versicolorin C