title: Urinary phthalate metabolites are associated with insulin resistance in obese subjects.
abstract: Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance.
authors.affiliation: Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium. Electronic address: eveline.dirinck@uza.be.
authors.forename: Eveline
authors.initials: E
authors.lastname: Dirinck
authors.affiliation: Toxicology Centre, University of Antwerp, Antwerp, Belgium.
authors.forename: Alin C
authors.initials: AC
authors.lastname: Dirtu
authors.affiliation: Toxicology Centre, University of Antwerp, Antwerp, Belgium.
authors.forename: Tinne
authors.initials: T
authors.lastname: Geens
authors.affiliation: Toxicology Centre, University of Antwerp, Antwerp, Belgium.
authors.forename: Adrian
authors.initials: A
authors.lastname: Covaci
authors.affiliation: Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Van Gaal
authors.affiliation: Department of Clinical Pharmacology, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium.
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Jorens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium; D001786:Blood Glucose / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000209:etiology / Q000503:physiopathology*; D050177:Overweight / Q000209:etiology / Q000503:physiopathology*; D010795:Phthalic Acids / Q000652:urine*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D010795:Phthalic Acids
keywords: Beta-cell function; Diabetes; Insulin resistance; Obesity; Oral glucose tolerance test; Phthalates