title: A survey of advancements in nucleic acid-based logic gates and computing for applications in biotechnology and biomedicine.
abstract: Nucleic acid-based logic devices were first introduced in 1994. Since then, science has seen the emergence of new logic systems for mimicking mathematical functions, diagnosing disease and even imitating biological systems. The unique features of nucleic acids, such as facile and high-throughput synthesis, Watson-Crick complementary base pairing, and predictable structures, together with the aid of programming design, have led to the widespread applications of nucleic acids (NA) for logic gate and computing in biotechnology and biomedicine. In this feature article, the development of in vitro NA logic systems will be discussed, as well as the expansion of such systems using various input molecules for potential cellular, or even in vivo, applications.
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA. tan@chem.ufl.edu.
authors.forename: Cuichen
authors.initials: C
authors.lastname: Wu
authors.forename: Shuo
authors.initials: S
authors.lastname: Wan
authors.forename: Weijia
authors.initials: W
authors.lastname: Hou
authors.forename: Liqin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiehua
authors.initials: J
authors.lastname: Xu
authors.forename: Cheng
authors.initials: C
authors.lastname: Cui
authors.forename: Yanyue
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D020811:Biomedical Technology; D001709:Biotechnology; D039301:Computers, Molecular; D006801:Humans; D008128:Logic; D008670:Metals / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D009696:Nucleic Acids / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D008670:Metals; D009696:Nucleic Acids