title: Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland.
abstract: A case of a pleomorphic adenoma of the lacrimal gland with a prominent clear cell myoepitheliomatous component was reported. An 81-year-old Caucasian woman experienced a 2-month history of right supraorbital swelling and proptosis. Excisional biopsy revealed a multicomponent lesion including a stromal component featuring glandular structures made of small epithelioid and spindle cells and a trabecular component with small islands of vacuolated cells, displaced nuclei, and clear cytoplasm. Immunohistochemical analysis revealed strong cytokeratin AE1/3 reactivity and focal smooth muscle actin positivity. The pathologic findings including immunohistochemistry results were consistent with a pleomorphic adenoma with prominent clear cell myoepithelioma component.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
authors.forename: Adewumi N
authors.initials: AN
authors.lastname: Adekunle
authors.forename: Pia R
authors.initials: PR
authors.lastname: Mendoza
authors.forename: Ted H
authors.initials: TH
authors.lastname: Wojno
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D008949:Adenoma, Pleomorphic / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D005134:Eye Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009363:Neoplasm Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins