title: Collaborative computational project for electron cryo-microscopy.
abstract: The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has recently been established. The aims of the project are threefold: to build a coherent cryoEM community which will provide support for individual scientists and will act as a focal point for liaising with other communities, to support practising scientists in their use of cryoEM software and finally to support software developers in producing and disseminating robust and user-friendly programs. The project is closely modelled on CCP4 for macromolecular crystallography, and areas of common interest such as model fitting, underlying software libraries and tools for building program packages are being exploited. Nevertheless, cryoEM includes a number of techniques covering a large range of resolutions and a distinct project is required. In this article, progress so far is reported and future plans are discussed.
authors.affiliation: Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, England.
authors.forename: Chris
authors.initials: C
authors.lastname: Wood
authors.affiliation: Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, England.
authors.forename: Tom
authors.initials: T
authors.lastname: Burnley
authors.affiliation: European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England.
authors.forename: Ardan
authors.initials: A
authors.lastname: Patwardhan
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
authors.forename: Sjors
authors.initials: S
authors.lastname: Scheres
authors.affiliation: Biological Sciences at Birkbeck, University of London, Malet Street, London WC1E 7HX, England.
authors.forename: Maya
authors.initials: M
authors.lastname: Topf
authors.affiliation: Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, England.
authors.forename: Alan
authors.initials: A
authors.lastname: Roseman
authors.affiliation: Scientific Computing Department, Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD, England.
authors.forename: Martyn
authors.initials: M
authors.lastname: Winn
mesh_terms: D003299:Cooperative Behavior; D020285:Cryoelectron Microscopy / Q000379:methods*
keywords: CCP-EM; Collaborative Computational Project for Electron cryo-Microscopy