title: Rapid-onset piperacillin-tazobactam induced thrombocytopenia.
abstract: Thrombocytopenia can occur from a variety of etiologies. Drug-induced thrombocytopenia is known to occur with beta-lactam medications, but often in the setting of prolonged use. We describe 2 patients who developed rapid-onset thrombocytopenia from piperacillin/tazobactam. Other causes of immediate thrombocytopenia were excluded. These cases describe a rare presentation of rapid-onset thrombocytopenia in a commonly used medication.
authors.affiliation: Department of Internal Medicine, St Luke's University Hospital, Bethlehem, PA, USA.
authors.forename: Shamsuddin
authors.initials: S
authors.lastname: Shaik
authors.affiliation: Department of Medicine, Emory University Hospital, Atlanta, GA, USA hkazi@emory.edu.
authors.forename: Haseeb A
authors.initials: HA
authors.lastname: Kazi
authors.affiliation: Section of Infectious Diseases, St Luke's University Hospital, Bethlehem, PA, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Ender
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000009:adverse effects*; D000078142:Tazobactam; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin
keywords: drug information; internal medicine