title: Duration of symptom and ABCD2 score as predictors of risk of early recurrent events after transient ischemic attack: a hospital-based case series study.
abstract: BACKGROUND
  The aim of this study was to refine clinical risk factor stratification and make an optimal intervention plan to prevent ischemic stroke.
  
  
  METHODS
  Clinical data, including diffusion-weighted imaging (DWI) findings, were collected in a cohort of hospitalized transient ischemic attack (TIA) patients from January 2010 to December 2011. Recurrent cerebrovascular events after TIA, including recurrent TIA, minor stroke, and major stroke, were identified by face-to-face follow-up. A multivariate, ordinal, logistic regression model was used to determine significant predictors of recurrent events.
  
  
  RESULTS
  Of 106 TIA patients, 24 (22.6%) had recurrent TIA and 20 (18.9%) had a stroke within 7 days. Hypertension, dyslipidemia, a history of ischemic stroke or TIA, and ABCD2 score were significantly associated with the recurrent events after TIA (P<0.001, P=0.02, P<0.001, P=0.02). Hypertension (RR=9.21; 95% CI, 3.07-27.61, P<0.001) and duration of symptom (RR=1.10; 95% CI, 1.02-1.17, P=0.01) as an item of ABCD2 score were highly predictive of the severity of recurrent events, whereas ABCD2 score as a whole (P=0.18) proved to be less strongly predictive.
  
  
  CONCLUSIONS
  A history of hypertension and long duration of symptom independently and significantly predict severe recurrent events after TIA within 7 days, but a high ABCD2 score was less strongly predictive of severe recurrent events.
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (mainland).
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (mainland).
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (mainland).
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (mainland).
authors.forename: Min
authors.initials: M
authors.lastname: Fang
authors.affiliation: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (mainland).
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000368:Aged; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006760:Hospitalization; D006761:Hospitals; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C431694:ABCD2 protein, human; D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters