title: Anion transport through lipids in a hybrid bilayer membrane.
abstract: In this report, we use a hybrid bilayer membrane (HBM) as an electrochemical platform to study anion diffusion through a lipid monolayer. We first append lipid on a self-assembled monolayer (SAM) that contains a covalently bound Cu(I)/Cu(II) redox center. We then perform cyclic voltammetry (CV) using different anions in bulk solution and extract thermodynamic and kinetic information about anion transport. We analyze the results using linear combinations of fundamental chemical trends and determine that anion transport quantitatively correlates to polarity and basicity, a relationship we formalize as the lipid permeability parameter. In addition, we discuss how our findings can be interpreted according to the two leading mechanisms describing ion permeability through lipids. Our results demonstrate that anion transport in a HBM is best described by the solubility-diffusion mechanism, not the pore mechanism.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors.forename: Edmund C M
authors.initials: EC
authors.lastname: Tse
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Barile
authors.forename: John P
authors.initials: JP
authors.lastname: Gewargis
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zimmerman
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Gewirth
mesh_terms: D000838:Anions / Q000378:metabolism; D055664:Electrochemical Techniques; D017136:Ion Transport; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000838:Anions; D008051:Lipid Bilayers; D008055:Lipids