title: Rheumatoid arthritis. The two faces of Rsk2 in hyperplastic disease.
abstract: Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?
authors.affiliation: Rheumatology Research Group, Centre for Translational Inflammation Research, School of Immunity &Infection, College of Medical &Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Falconer
authors.affiliation: Rheumatology Research Group, Centre for Translational Inflammation Research, School of Immunity &Infection, College of Medical &Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, UK.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Buckley
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D010450:Endopeptidases; D019317:Evidence-Based Medicine; D005347:Fibroblasts / Q000276:immunology; D018093:Gelatinases / Q000235:genetics; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D010641:Phenotype; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000276:immunology; D012697:Serine Endopeptidases / Q000235:genetics; D013582:Synovial Fluid / Q000276:immunology; D000099167:Fibroblast Activation Protein Alpha
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D010450:Endopeptidases; D018093:Gelatinases; D008565:Membrane Proteins; D038744:Ribosomal Protein S6 Kinases, 90-kDa; D012697:Serine Endopeptidases; D000099167:Fibroblast Activation Protein Alpha; C069330:ribosomal protein S6 kinase, 90kDa, polypeptide 3