title: Targeting Galectin-1 in pancreatic cancer: immune surveillance on guard.
abstract: The tumor microenviroment and immune barrier are known to modulate malignant disease progression. We have recently identified Galectin-1 as a key player in a novel stromal regulatory reaction driving immune evasion in pancreatic tumors in vivo. These results suggest that Galectin-1 inhibition represents a potential therapeutic strategy for one of the most deadly types of cancer.
authors.affiliation: Cancer Research Program; IMIM (Hospital del Mar Medical Research Institute) ; Barcelona, Spain.
authors.forename: Neus
authors.initials: N
authors.lastname: Martínez-Bosch
authors.affiliation: Cancer Research Program; IMIM (Hospital del Mar Medical Research Institute) ; Barcelona, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Navarro
keywords: Galectin-1; immune evasion; immunosurveillance; pancreatic cancer; stroma; tumor microenvironment