title: Metabolic syndrome and inflammatory biomarkers in adults: a population-based survey in Western region of iran.
abstract: BACKGROUND
  There is evidence that inflammation may be involved in pathogenesis of MetS. Inflammatory biomarkers are moving to the forefront as the potent predictors of MetS.
  
  
  OBJECTIVE
  The present study aimed to evaluate the association between MetS and some inflammatory biomarkers.
  
  
  METHODS
  This community-based cross-sectional study was conducted on 800 subjects aged above 35 years selected through random sampling in Borujerd (west of Iran) from 2011 to 2013. MetS was defined based on ATP III criteria and the subjects were divided into two groups (MetS and non-MetS groups). Waist circumference and Body Mass Index (BMI) were calculated. In addition, blood samples were taken and C-Reactive Protein (CRP), lipid profile, Fasting Blood Sugar (FBS), and Bleeding Time (BT) were measured. Then, the correlations between MetS and the above-mentioned variables were estimated. After all, the data were entered into the SPSS statistical software (v. 17) and analyzed using T-test, chi-square, median test, and spearman's rank correlation.
  
  
  RESULTS
  In this study, 344 subjects (43%) met the ATP III criteria. The results showed a significant difference between MetS and non-MetS groups regarding BMI, white blood cell, total cholesterol, LDL, platelet, and high-sensitivity CPR (hs-CRP) (P < 0.0001, P = 0.040, P < 0.0001, P < 0.0001, and P = 0.045, respectively). Besides, waist circumference, Triglyceride (TG), FBS, and systolic and diastolic blood pressure were significantly higher, while HDL was significantly lower in the MetS group (P < 0.0001).
  
  
  CONCLUSIONS
  The incidence rate of MetS in our survey was higher compared to the previous reports. In addition, this incidence rate was higher in females in comparison to males. The results also showed a significant correlation between inflammatory biomarkers and MetS and that the higher levels of hs-CRP were associated with higher rate of MetS.
authors.affiliation: Department of Cardiology, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Maleki
authors.affiliation: Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Negin
authors.initials: N
authors.lastname: Rashidi
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Aghaei Meybodi
authors.affiliation: Department of Cardiology, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Montazeri
authors.affiliation: Young Researchers Club, Islamic Azad University, Babol Branch, Babol, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Montazeri
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, German Heart Center, Berlin, Germany.
authors.forename: Farid
authors.initials: F
authors.lastname: Falsafi
authors.affiliation: Department of Cardiology, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Ghanavati
authors.affiliation: School of Nursing, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Forughi
authors.affiliation: Imam Khomeini Hospital, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Alyari
keywords: Body Mass Index; C-Reactive Protein; Metabolic Syndrome; Waist Circumference