title: Detoxification of organophosphorus pesticides and nerve agents through RSDL: efficacy evaluation by (31)P NMR spectroscopy.
abstract: Intoxication by organophosphorus compounds, especially by pesticides, poses a considerable risk to the affected individual. Countermeasures involve both medical intervention by means of antidotes as well as external decontamination to reduce the risk of dermal absorption. One of the few decontamination options available is Reactive Skin Decontamination Lotion (RSDL), which was originally developed for military use. Here, we present a (31)P NMR spectroscopy based methodology to evaluate the detoxification efficacy of RSDL with respect to a series of organophosphorus pesticides and nerve agents. Kinetic analysis of the obtained NMR data provided degradation half-lives proving that RSDL is also reasonably effective against organophosphorus pesticides. Unexpected observations of different RSDL degradation patterns are presented in view of its reported oximate-catalyzed mechanism of action.
authors.affiliation: Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany. Electronic address: paulelsinghorst@bundeswehr.org.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Elsinghorst
authors.affiliation: Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Worek
authors.affiliation: Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937 München, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Koller
mesh_terms: D000931:Antidotes / Q000737:chemistry*; D002619:Chemical Warfare Agents / Q000737:chemistry / Q000302:isolation & purification*; D003666:Decontamination / Q000379:methods*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006207:Half-Life; D009682:Magnetic Resonance Spectroscopy; D009824:Ointments / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000302:isolation & purification; D010575:Pesticides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000931:Antidotes; D002619:Chemical Warfare Agents; D003879:Dermatologic Agents; D009824:Ointments; D009943:Organophosphorus Compounds; D010575:Pesticides
keywords: (31)P NMR; Degradation; Nerve agents; Organophosphorus compounds; Pesticides; RSDL