title: [A case of thymic cancer effectively treated by weekly paclitaxel combined with carboplatin].
abstract: A 65-year-old woman with left chest pain, back pain, and palpitation that had persisted for 2 months was referred to our hospital. Computed tomography of her chest showed an anterior mediastinal tumor with mediastinal lymphadenopathy, left pleural effusion, and pericardial effusion. Endobronchial ultrasound-guided transbronchial needle aspiration of the subcarinal lymphadenopathy was performed. The pathological findings and other examinations such as bone scintigraphy suggested advanced thymic cancer (stage IV b according to the Masaoka classification of thymic epithelial tumors). The patient was treated with combination chemotherapy of carboplatin(area under the curve [AUC]=6, 656 mg/body, day 1) and weekly paclitaxel (70 mg/m², 100 mg/body, days 1, 8, and 15). After 4 cycles of chemotherapy, a partial response was achieved and the pericardial effusion disappeared. The patient did not experience any severe toxicity, except for grade 1 nausea, grade 2 anemia, and grade 2 alopecia. Weekly paclitaxel combined with carboplatin appears to be a useful regimen with minimal toxicity for advanced thymic cancer.
authors.affiliation: Dept. of Internal Medicine II, Niigata University Medical and Dental Hospital.
authors.forename: Rie
authors.initials: R
authors.lastname: Kondo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Ohshima
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Asakawa
authors.forename: Takuro
authors.initials: T
authors.lastname: Sakagami
authors.forename: Masaaki
authors.initials: M
authors.lastname: Okajima
authors.forename: Satoru
authors.initials: S
authors.lastname: Miura
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Junta
authors.initials: J
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kagamu
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yoshizawa
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D016190:Carboplatin; D017239:Paclitaxel