title: Opposite effects of oxytocin on water intake induced by hypertonic NaCl or polyethylene glycol administration.
abstract: Oxytocin (OT), a neurohormone, has been related to natriuretic and diuretic effects and also to water intake and sodium appetite. The objective of the present study was to determine the effect of subcutaneous OT administration on water intake and urine-related measures induced by the administration of hypertonic NaCl (experiment 1) or polyethylene glycol (PEG) (experiment 2). Experiment 1 showed that OT administration increases the urine volume, urinary sodium concentration, and natriuresis and reduces the water intake, water and sodium balances, and estimated plasma sodium concentration induced by hypertonic NaCl administration. Conversely, experiment 2 showed that OT administration increases the water intake and the antidiuretic response induced by PEG administration. These results show that the opposite effects of OT on the water intake induced by hypertonic NaCl or PEG administration are accompanied by differential regulatory effects, enhancing a natriuretic response in the first experiment and generating an antidiuretic reaction in the second experiment. This study suggests a differential regulatory effect of OT during states of intra- and extracellular thirst.
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain. Electronic address: antoniobernal@ugr.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bernal
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Mahía
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mediavilla
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
authors.forename: Amadeo
authors.initials: A
authors.lastname: Puerto
mesh_terms: D000818:Animals; D004326:Drinking / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*
chemical_list: D012462:Saline Solution, Hypertonic; D011092:Polyethylene Glycols; D010121:Oxytocin
keywords: Antidiuresis; Kaliuresis; NaCl; Natriuresis; Oxytocin; Polyethylene glycol; Water intake