title: An integrated optofluidic device for single-cell sorting driven by mechanical properties.
abstract: We present a novel optofluidic device for real-time sorting on the basis of cell mechanical properties, measured by optical stretching. The whole mechanism, based on optical forces, does not hamper the viability of the tested cells, which can be used for further analysis. The device effectiveness is demonstrated by extracting a sample population enriched with highly metastatic cells from a heterogeneous cell mixture.
authors.affiliation: Dipartimento di Ingegneria Industriale e dell'Informazione, Università di Pavia, Via Ferrata 5A, 27100 Pavia, Italy. paolo.minzioni@unipv.it.
authors.forename: T
authors.initials: T
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Paiè
authors.forename: G
authors.initials: G
authors.lastname: Nava
authors.forename: F
authors.initials: F
authors.lastname: Bragheri
authors.forename: R
authors.initials: R
authors.lastname: Martinez Vazquez
authors.forename: P
authors.initials: P
authors.lastname: Minzioni
authors.forename: M
authors.initials: M
authors.lastname: Veglione
authors.forename: M
authors.initials: M
authors.lastname: Di Tano
authors.forename: C
authors.initials: C
authors.lastname: Mondello
authors.forename: R
authors.initials: R
authors.lastname: Osellame
authors.forename: I
authors.initials: I
authors.lastname: Cristiani
mesh_terms: D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation*; D048430:Cell Shape; D048429:Cell Size; D006801:Humans; D008545:Melanoma / Q000473:pathology; D046210:Microfluidic Analytical Techniques; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000473:pathology