title: Surface morphology changes of polymer membrane and carbon paste sertraline sensors.
abstract: Polymer membrane and chemically modified carbon paste (CMCP) sensors for determination of sertraline HCl (Ser-Cl) incorporating sertraline tetraphenylborate (Ser-TPB) as an electro-active material were constructed. They showed a rapid and linear response for Ser-ion over the concentration range 0.01-10.00 mmol L(-1). The limits of detection were 2.80 and 9.55 μmol L(-1), and Nernastian slopes were 56.60, 59.60 mV decade(-1) for membrane and CMCP sensors for batch method. In flow injection analysis (FIA), the electrodes revealed comparatively good selectivity for Ser-ion with regard to a wide variety of different cations, sugars, and amino acids. The addition of different anionic additives, namely sodium tetraphenylborate (NaTPB), potassium tetraphenylborate (KTPB), potassium tetrakis[3,5-bis-(triflouromethyl)phenyl]borate (KTFMPB), and sodium tetrakis[3,5-bis(trifluoro-methyl)phenyl]borate (NaTFMPB), to the prepared mixture improved their response characteristics. The surface morphologies of membrane films containing PVC only (blank), plasticizer+PVC, Ser-TPB+plasticizer+PVC, and Ser-TPB +plasticizer+PVC+additive were studied using scanning and atomic force electron microscopes. These sensors had been used in the potentiometric titration of Ser-ion against NaTPB. Standard addition method for the pure raw material and some of its pharmaceutical tablets was used for Ser-Cl determination. The obtained results were tested for their repeatability and reproducibility and were statistically treated by F- and t- tests.
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Khater
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: H B
authors.initials: HB
authors.lastname: Hassib
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: yousrymi@yahoo.com.
authors.forename: Y M
authors.initials: YM
authors.lastname: Issa
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: S H
authors.initials: SH
authors.lastname: Mohammed
mesh_terms: D001881:Borates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008567:Membranes, Artificial; D010968:Plasticizers / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D020280:Sertraline / Q000032:analysis* / Q000737:chemistry*; D013499:Surface Properties; D013775:Tetraphenylborate / Q000737:chemistry*
chemical_list: D001881:Borates; D006845:Hydrocarbons, Fluorinated; D008567:Membranes, Artificial; D010968:Plasticizers; C000597414:tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; D013775:Tetraphenylborate; D002244:Carbon; D011143:Polyvinyl Chloride; D020280:Sertraline
keywords: Carbon paste sensor; Graphite; Membrane sensor; SEM; Sertraline HCl; Tetraphenylborate