title: A systems approach to drug discovery in Alzheimer's disease.
abstract: In the articles included in this volume, one feels a strong frustration among the writers with the slow course of therapeutics development for Alzheimer's disease and with the clinical failure of targeted therapeutic agents despite substantial progress in our understanding of the biology and biochemistry of the disease.
authors.affiliation: Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA, mls7@columbia.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Shelanski
authors.forename: William
authors.initials: W
authors.lastname: Shin
authors.forename: Soline
authors.initials: S
authors.lastname: Aubry
authors.forename: Peter
authors.initials: P
authors.lastname: Sims
authors.forename: Mariano J
authors.initials: MJ
authors.lastname: Alvarez
authors.forename: Andrea
authors.initials: A
authors.lastname: Califano
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D013597:Systems Analysis