title: Improved ion optics for introduction of ions into a 9.4-T Fourier transform ion cyclotron resonance mass spectrometer.
abstract: Enhancements to the ion source and transfer optics of our 9.4 T Fourier transform ion cyclotron resonance (ICR) mass spectrometer have resulted in improved ion transmission efficiency for more sensitive mass measurement of complex mixtures at the MS and MS/MS levels. The tube lens/skimmer has been replaced by a dual ion funnel and the following octopole by a quadrupole for reduced ion cloud radial expansion before transmission into a mass-selective quadrupole. The number of ions that reach the ICR cell is increased by an order of magnitude for the funnel/quadrupole relative to the tube lens/skimmer/octopole.
authors.affiliation: Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, FL, 32310, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Franklin E
authors.initials: FE
authors.lastname: Leach
authors.forename: Nathan K
authors.initials: NK
authors.lastname: Kaiser
authors.forename: Xibei
authors.initials: X
authors.lastname: Dang
authors.forename: Yehia M
authors.initials: YM
authors.lastname: Ibrahim
authors.forename: Randolph V
authors.initials: RV
authors.lastname: Norheim
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Anderson
authors.forename: Richard D
authors.initials: RD
authors.lastname: Smith
authors.forename: Alan G
authors.initials: AG
authors.lastname: Marshall
mesh_terms: D001059:Apoproteins / Q000032:analysis; D017357:Cyclotrons; D006367:HeLa Cells; D006454:Hemoglobins / Q000032:analysis; D006657:Histones / Q000032:analysis; D006801:Humans; D007477:Ions; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D001059:Apoproteins; D006454:Hemoglobins; D006657:Histones; D007477:Ions; C023478:apohemoglobin
keywords: FT MS; ICR; ion funnel; mass selection; quadrupole ion guide