title: Radiolabeled antibodies for therapy of infectious diseases.
abstract: Novel approaches to treatment of infectious diseases are urgently needed. This need has resulted in renewing the interest in antibodies for therapy of infectious diseases. Radioimmunotherapy (RIT) is a cancer treatment modality, which utilizes radiolabeled monoclonal antibodies (mAbs). During the last decade we have translated RIT into the field of experimental fungal, bacterial and HIV infections. In addition, successful proof of principle experiments with radiolabeled pan-antibodies that bind to antigens shared by major pathogenic fungi were performed in vitro. The armamentarium of pan-antibodies would result in reducing the dependence on microorganism-specific antibodies and thus would speed up the development of RIT of infections. We believe that the time is ripe for deploying RIT into the clinic to combat infectious diseases.
authors.affiliation: Department of Radiology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10461 USA ; Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10461 USA.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Dadachova
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10461 USA ; Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10461 USA.
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall