title: A new flavonol triglycoside derived from Anoectochilus elwesii on stimulating glucose uptake in insulin-induced human HepG2 cells.
abstract: A novel flavonol triglycoside (4), isorhamnetin-3-O-β-D-glucopyranosyl (1→2)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside, named elwesoside A, together with six known flavonols (1-3, 5-7) was isolated from Anoectochilus elwesii (Clarke ex Hook. f.) King et Pantl. and its structure was elucidated by extensive spectroscopic methods and comparison with the literature data. All compounds were first reported in this plant and two of them (4 and 5) were the first examples of flavonol triglycosides isolated from Anoectochilus genus. The effects of 1-7 were evaluated on insulin-treated human HepG2 cells under high glucose conditions for stimulating glucose uptake activities. The novel compound (4) displayed highly potent dose-dependent effect on the stimulation of glucose uptake in insulin-resistant human HepG2 cells.
authors.affiliation: a School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou 510006 , People's Republic of China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Cai
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.forename: En
authors.initials: E
authors.lastname: Zhu
mesh_terms: D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification; D005947:Glucose / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D007333:Insulin Resistance; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*
chemical_list: D044948:Flavonols; D006027:Glycosides; C000601326:elwesoside A; D005947:Glucose
keywords: Anoectochilus elwesii; flavonol triglycoside; insulin-resistant human HepG2 cells