title: Gold-oxoborate nanocomposites and their biomedical applications.
abstract: A novel inorganic nanocomposite material, called BOA, which has the form of small building blocks composed of gold nanoparticles embedded in a polyoxoborate matrix, is presented. It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward both Gram-positive and -negative bacteria strains. Importantly, the modified cotton does not release any toxic substances, and the bacteria are killed upon contact with the fibers coated with the BOA. Toxicity tests show that the nanocomposite--in spite of its antiseptic properties--is harmless for mammalian cells. The presented method of surface modification utilizes mild, environmentally friendly fabrication conditions. Thus, it offers a facile approach to obtain durable nontoxic antiseptic coatings for biomedical applications.
authors.affiliation: Institute of Physical Chemistry of the Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wybrańska
authors.forename: Jan
authors.initials: J
authors.lastname: Paczesny
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Serejko
authors.forename: Karolina
authors.initials: K
authors.lastname: Sura
authors.forename: Karolina
authors.initials: K
authors.lastname: Włodyga
authors.forename: Igor
authors.initials: I
authors.lastname: Dzięcielewski
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Jones
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Śliwa
authors.forename: Iwona
authors.initials: I
authors.lastname: Wybrańska
authors.forename: Robert
authors.initials: R
authors.lastname: Hołyst
authors.forename: Oren A
authors.initials: OA
authors.lastname: Scherman
authors.forename: Marcin
authors.initials: M
authors.lastname: Fiałkowski
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001881:Borates / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013784:Textiles / Q000032:analysis / Q000382:microbiology; D014935:Wool / Q000737:chemistry / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D001881:Borates; D006046:Gold
keywords: antibacterial coating; cytotoxicity; gold nanoparticles; nanocomposite; oxoborates; surface modification