title: Periductal Stromal Sarcoma of the Breast With Liposarcomatous Differentiation: A Case Report With 10-Year Follow-up and Literature Review.
abstract: A biphasic tumor with features of benign ductal elements and a malignant stromal component that lacks the architecture of a phylloides tumor represents a diagnostic challenge. A 35-year-old woman presented with a painful mass located in the upper inner quadrant of the right breast. A biopsy revealed histologically that the tumor had a multinodular architecture with malignant spindle cells forming cuffs around multiple open benign ducts. No leaf-like architecture was present. In addition, liposarcomatous differentiation was seen in focal areas. Immunohistochemical staining showed positive for CD34, vimentin and CDK4, and negative for ER, PR, Her2/neu, CD10, CD117, p63, bcl-2, cytokeratin, and MDM2. A diagnosis of periductal stromal sarcoma with liposarcomatous differentiation was established. Following excision with mastectomy and adjuvant chemotherapy, the patient was disease-free for 10 years. To our knowledge, this is the first case report of periductal stromal sarcoma showing liposarcomatous differentiation.
authors.affiliation: Jacobi Medical Center, Bronx, NY, USA.
authors.forename: Sherrie Renee
authors.initials: SR
authors.lastname: White
authors.affiliation: Hofstra-North Shore Long Island Jewish School of Medicine, Hempstead, NY, USA.
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Auguste
authors.affiliation: Hofstra-North Shore Long Island Jewish School of Medicine, Hempstead, NY, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.affiliation: Hofstra-North Shore Long Island Jewish School of Medicine, Hempstead, NY, USA tbhuiya@nshs.edu.
authors.forename: Tawfiqul
authors.initials: T
authors.lastname: Bhuiya
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology*; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012509:Sarcoma / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: liposarcomatous differentiation; nonphylloides sarcoma of breast; periductal stromal sarcoma