title: Frequency of gall bladder carcinoma in patients with acute and chronic cholecystitis.
abstract: BACKGROUND
  Gallbladder carcinoma is a relatively uncommon neoplasm which is more common in the seventh decade of life compared to that of cholelithiasis which is in the fourth decade. The objective of the study was to determine the frequency of carcinoma gall bladder in cases of acute and chronic cholecystitis particularly with reference to cholelithiasis.
  
  
  METHODS
  This cross-sectional observational study was done in the department of Surgery at Fauji Foundation Hospital, Rawalpindi from 1st January, 2009 till 3 1st October, 2011. All 310 cholecystectomies performed during this period were included in this study. The specimens collected were macroscopically examined and sent for histopathology. All the reports were reviewed and the results recorded.
  
  
  RESULTS
  Out of 310 cases, 27 (8.7%) had acute cholecystitis and 280 (91.2%) were chronic cholecystitis. 3 specimens got autolysed and therefore excluded from the study. 290 cases had cholelithiasis. 2 out of 290 calculous cases were found to have coexistent carcinoma gall bladder proven on histopathology.
  
  
  CONCLUSIONS
  Frequency of carcinoma gallbladder associated with cholelithiasis discovered incidentally after cholecystectomy is very low in our patients.
authors.affiliation: Department of Surgery, Fauji Foundation Hospital, Rawalpindi, Pakistan. dr.najamulhaq@gmail.com
authors.forename: Najamul
authors.initials: N
authors.lastname: Haq
authors.forename: Basharat Ali
authors.initials: BA
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.forename: Adeel
authors.initials: A
authors.lastname: Akram
authors.forename: Abdul Basit
authors.initials: AB
authors.lastname: Jamal
authors.forename: Fatima
authors.initials: F
authors.lastname: Bangash
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002764:Cholecystitis / Q000453:epidemiology*; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005706:Gallbladder Neoplasms / Q000453:epidemiology*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged