title: Ochratoxin A as possible factor trigging autism and its male prevalence via epigenetic mechanism.
abstract: The role of dysbiosis causing leaky gut with xenobiotic production and absorption is increasingly demonstrated in autism spectrum disorder (ASD) pathogenesis. Among xenobiotics, we focused on ochratoxin A (one of the major food contaminating mycotoxin), that in vitro and in vivo exerts a male-specific neurotoxicity probably via microRNA modulation of a specific target gene. Among possible targets, we focused on neuroligin4X. Interestingly, this gene carries some single nucleotide polymorphisms (SNPs) already correlated with the disease and with illegitimate microRNA binding sites and, being located on X-chromosome, could explain the male prevalence. In conclusion, we propose a possible gene-environment interaction triggering ASD explaining the epigenetic neurotoxic mechanism activated by ochratoxin A in genetically predisposed children. This mechanism offers a clue for male prevalence of the disease and may have an important impact on prevention and cure of ASD.
authors.forename: A
authors.initials: A
authors.lastname: Mezzelani
authors.forename: M E
authors.initials: ME
authors.lastname: Raggi
authors.forename: A
authors.initials: A
authors.lastname: Marabotti
authors.forename: L
authors.initials: L
authors.lastname: Milanesi
mesh_terms: D000067877:Autism Spectrum Disorder / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics; D001321:Autistic Disorder / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism; D002648:Child; D041321:Chromosomes, Human, X; D064806:Dysbiosis / Q000453:epidemiology*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009793:Ochratoxins / Q000633:toxicity*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012737:Sex Factors
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D035683:MicroRNAs; C430845:NLGN4X protein, human; D009793:Ochratoxins; C025589:ochratoxin A
keywords: Autism; Environment; Epigenetics; Male-prevalence; Microbiota; Ochratoxin A