title: Alkyne hydroacylation: switching regioselectivity by tandem ruthenium catalysis.
abstract: By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl vs ethyl substituent on the alkyne. Mechanistic studies suggest that the regioselectivity results from a selective allene formation that is governed by allylic strain.
authors.affiliation: Department of Chemistry, University of California-Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.
authors.forename: Qing-An
authors.initials: QA
authors.lastname: Chen
authors.forename: Faben A
authors.initials: FA
authors.lastname: Cruz
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
mesh_terms: D000215:Acylation; D000480:Alkynes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001547:Benzaldehydes; D012428:Ruthenium; C032175:benzaldehyde