title: Concurrent interspecies and clonal dissemination of OXA-48 carbapenemase.
abstract: Several isolates of four different carbapenemase-producing Enterobacteriaceae species were recovered from a patient hospitalized for 4 months in a teaching hospital in Madrid. These species comprised seven Klebsiella pneumoniae belonging to ST15, four Escherichia coli belonging to ST2531, two Serratia marcescens and one Citrobacter freundii. This patient was the index case of a small outbreak of four patients infected and/or colonized by carbapenemase-producing K. pneumoniae. Molecular results identified the bla(OXA-48) gene in all Enterobacteriaceae isolates from the index case and in all isolates from the other three patients, suggesting intra- and interpatient dissemination. Our results highlight the great ability of OXA-48 carbapenemase to spread among different enterobacterial species by both clonal and nonclonal dissemination.
authors.affiliation: Servicio de Microbiología, Hospital Universitario de Getafe, Spain.
authors.forename: D M
authors.initials: DM
authors.lastname: Arana
authors.affiliation: Antibiotic Laboratory, Bacteriology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Saez
authors.affiliation: Servicio de Microbiología, Hospital Universitario de Getafe, Spain.
authors.forename: P
authors.initials: P
authors.lastname: García-Hierro
authors.affiliation: Antibiotic Laboratory, Bacteriology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Bautista
authors.affiliation: Antibiotic Laboratory, Bacteriology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Fernández-Romero
authors.affiliation: Unidad de Cuidados Intensivos y Grandes Quemados, Hospital Universitario de Getafe, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ángel de la Cal
authors.affiliation: Servicio de Microbiología, Hospital Universitario de Getafe, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Alós
authors.affiliation: Antibiotic Laboratory, Bacteriology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain. Electronic address: jesus.oteo@isciii.es.
authors.forename: J
authors.initials: J
authors.lastname: Oteo
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission; D004196:Disease Outbreaks; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000635:transmission; D005260:Female; D005838:Genotype; D006784:Hospitals, Teaching; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D013030:Spain / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenemase; Klebsiella pneumoniae; OXA-48; ST15; interspecies dissemination