title: [Common variable immunodeficiency can present as a multisystemic disorder].
abstract: Common variable immunodeficiency is the second most common primary immunodeficiency with a prevalence of approx. 1/10.000-50.000. The clinical challenge is early diagnosis and efficient supportive treatment. The purpose of the present article is to focus on the complexity of the disease, including the risk of a long pre-diagnostic period and to focus on the sarcoidosis-like variant and the possible impact of immunoglobulin subclass deficiency.
authors.forename: Rasmus Møller
authors.initials: RM
authors.lastname: Jørgensen
authors.forename: Annebirthe Bo
authors.initials: AB
authors.lastname: Hansen
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Cannon
authors.affiliation: Hospitalsenhed Vest, Medicinsk Afdeling, Lægårdvej 12, 7500 Holstebro. npeterslund@gmail.com.
authors.forename: Niels A
authors.initials: NA
authors.lastname: Peterslund
mesh_terms: D000293:Adolescent; D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D057210:Delayed Diagnosis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors