title: Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion.
abstract: Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.
authors.affiliation: Departments of Pathology; Johns Hopkins School of Medicine ; Baltimore, MD USA.
authors.forename: Chih-Ping
authors.initials: CP
authors.lastname: Mao
authors.affiliation: Departments of Pathology; Johns Hopkins School of Medicine ; Baltimore, MD USA ; Obstetrics & Gynecology; Johns Hopkins School of Medicine ; Baltimore, MD USA ; Oncology; Johns Hopkins School of Medicine ; Baltimore, MD USA ; Molecular Microbiology & Immunology; Johns Hopkins School of Medicine ; Baltimore, MD USA.
authors.forename: Tc
authors.initials: T
authors.lastname: Wu
authors.affiliation: Division of Infection & Immunology; Korea University College of Medicine ; Seoul, South Korea ; Department of Biochemistry; Korea University College of Medicine ; Seoul, South Korea.
authors.forename: Kwon-Ho
authors.initials: KH
authors.lastname: Song
authors.affiliation: Division of Infection & Immunology; Korea University College of Medicine ; Seoul, South Korea ; Department of Biochemistry; Korea University College of Medicine ; Seoul, South Korea.
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Kim
keywords: Nanog; cytotoxic T lymphocytes; immune surveillance; immune-resistant; stem-like phenotype