title: Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.
abstract: The adult mammalian cerebellar cortex is generally assumed to have a uniform cytoarchitecture. Differences in cerebellar function are thought to arise primarily through distinct patterns of input and output connectivity rather than as a result of variations in cortical microcircuitry. However, evidence from anatomical, physiological and genetic studies is increasingly challenging this orthodoxy, and there are now various lines of evidence indicating that the cerebellar cortex is not uniform. Here, we develop the hypothesis that regional differences in properties of cerebellar cortical microcircuits lead to important differences in information processing.
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
authors.forename: Nadia L
authors.initials: NL
authors.lastname: Cerminara
authors.affiliation: Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lang
authors.affiliation: Department of Pathology &Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Roy V
authors.initials: RV
authors.lastname: Sillitoe
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Apps
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology*