title: Synthesis of fluorinated and nonfluorinated graphene quantum dots through a new top-down strategy for long-time cellular imaging.
abstract: Herein, a new strategy has been developed through combining a microwave-assisted technique with hydrothermal treatment to reduce graphene waste and improve production yield of graphene quantum dots (GQDs) prepared by top-down methods. By using fluorinated graphene oxide (FGO) as a raw material, fluorinated GQDs and nonfluorinated GQDs can be synthesized. Additionally, in the fluorinated GQDs, the protective shell supplied by fluorine improves the pH stability of photoluminescence and the strong electron-withdrawing group, -F, reduces the π-electron density of the aromatic structure; thus inhibiting reactivity toward singlet oxygen produced during irradiation and improving the photostability. Therefore, the as-prepared fluorinated GQDs with excellent photo- and pH stability are suitable for long-term cellular imaging.
authors.affiliation: Laboratory of Chemical Biology and Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (P.R. China); University of the Chinese Academy of Science, Beijing, 100039 (P.R. China).
authors.forename: Hanjun
authors.initials: H
authors.lastname: Sun
authors.forename: Haiwei
authors.initials: H
authors.lastname: Ji
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Yijia
authors.initials: Y
authors.lastname: Guan
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D006108:Graphite / Q000737:chemistry*; D054879:Halogenation; D008872:Microwaves; D057054:Molecular Imaging / Q000379:methods; D010087:Oxides / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D010087:Oxides; D006108:Graphite
keywords: fluorescence; fluorine; graphene; imaging agents; quantum dots