title: A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease
abstract: The amyloid-β peptide (Aβ) has been associated with Alzheimer's disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for Aβ toxicity. Later, this hypothesis has been updated and soluble intracellular Aβ forms and their effects within the cell have come into focus.Mitochondrial dysfunction plays an important role in the pathophysiology of AD. Aβ was detected inside mitochondria and several mitochondrial proteins were found to interact directly with Aβ. Such interactionscan affecta protein's function and cause damage to the mitochondria and finally to the whole cell.This review summarizes the current knowledge of mitochondrial proteins directly interacting with Aβ and discusses their significance for the development of therapeutics in the treatment of AD.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Benek
authors.forename: Laura
authors.initials: L
authors.lastname: Aitken
authors.forename: Lukas
authors.initials: L
authors.lastname: Hroch
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Frank
authors.initials: F
authors.lastname: Gunn-Moore
authors.affiliation: : University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.. kamil.musilek@gmail.com.
authors.forename: Kamil
authors.initials: K
authors.lastname: Musilek