title: [Aneuploidies in oocytes used in IVF programs].
abstract: The aim of the study was to investigate with FISH the frequency of aneuploidies of the first and second polar bodies (PB-I and PB-II) of oocytes in women participating in IVF programs. The study included 93 women, 82 of them were after controlled ovulation stimulation (COS), 11 in natural cycles. FISH in 238 PB-I and PB-II was done. Revealed that the frequency of aneuploidies in oocytes after COS was higher than in the natural cycle, and also was higher after COS in women with infertility compared to women stimulated because of male infertility and donors of oocytes. Aneuploidies of oocytes after COS are more common in patients after 35 years old. Thus, the study of aneuplodies of PB-I and PB-II by FISH is an informative tool of pregestation genetic diagnosis.
authors.forename: V V
authors.initials: VV
authors.lastname: Grabar
authors.forename: A V
authors.initials: AV
authors.lastname: Stefanovich
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000145:classification; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007247:Infertility, Female / Q000235:genetics / Q000473:pathology; D008297:Male; D008423:Maternal Age; D009865:Oocytes / Q000473:pathology*; D010062:Ovulation Induction; D059705:Polar Bodies / Q000473:pathology*; D027724:Reproductive Techniques, Assisted