title: [Expression and role of Caveolin-1 in the angiogenesis of cerebral arteriovenous malformation].
abstract: OBJECTIVE
  To explore the expression and role of Caveolin-1 in the angiogenesis of cerebral arteriovenous malformation (AVM).
  
  
  METHODS
  A total of 55 fresh AVM samples at Affiliated Hospital, Inner Mongolia Medical University and Beijing Tiantan Hospital from August 2013 to May 2014 were collected to test the expressions of Caveolin-1, vascular endothelial growth factor (VEGF), vascular endothelial growth factor-receptor 2 (VEGF-R2) and endothelial nitric oxide synthase (eNOS) by immunohistochemistry and Western blot. And the relationship between the expressions of Caveolin-1 and VEGF, VEGF-R2 and eNOS was analysed.
  
  
  RESULTS
  The expression rates of Caveolin-1, VEGF, VEGF-R2 and eNOS in human AVM were 100%, 87.27%, 76.36% and 85.45%. And the values were significantly higher than those in normal superficial temporal artery. Western blot showed that the expressions of Caveolin-1, VEGF, VEGF-R2 and eNOS in hemorrahge AVM were higher than those in non-hemorrahge counterpart (P < 0.05). The expressions of Caveolin-1, VEGF, VEGF-R2 and eNOS were consistent.
  
  
  CONCLUSIONS
  Caveolin-1 plays a positive regulatory role in the angiogenesis of AVM through the PI3K/Akt signaling pathway. In cerebral AVM, Caveolin-1 plays an important role in occurrence, progression, hemorrahge and degradation of brain AVM.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital, Inner Mongolia Medical University, Hohehot 010059, China. Email: baijie0611@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Bai
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Zhao
authors.forename: Changwu
authors.initials: C
authors.lastname: Dou
authors.forename: Zhanpu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D051242:Caveolin 1; D002681:China; D006801:Humans; D002538:Intracranial Arteriovenous Malformations; D009389:Neovascularization, Pathologic; D052250:Nitric Oxide Synthase Type III; D019869:Phosphatidylinositol 3-Kinases; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2
chemical_list: D051242:Caveolin 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D019869:Phosphatidylinositol 3-Kinases; C000588866:KDR protein, human; D040301:Vascular Endothelial Growth Factor Receptor-2