title: Enhanced biostability of nanoparticle-based drug delivery systems by albumin corona.
abstract: OBJECTIVE
  The long-term efficacy of nanoparticles is limited by their rapid metabolism in tissues. In this work, we aim to enhance nanoparticle biostability by preforming a bovine serum albumin (BSA) corona.
  
  
  METHODS
  A BSA corona was formed by incubating poly-3-hydroxybutyrate-co-3-hydroxyhexanoate nanoparticles with BSA solution and confirmed by SDS-PAGE and x-ray photoelectron spectroscopy. The impacts of the BSA corona on the drug release, biostability and biodistribution of nanoparticles were investigated.
  
  
  RESULTS
  In the presence of the BSA corona, the drug release (coumarin-6 was used as the model drug) of nanoparticles was significantly slower and their stability in liver homogenate and in organs was enhanced.
  
  
  CONCLUSIONS
  Preformation of a BSA corona may be a promising approach for enhancing drug biostability and for developing long-acting nanoparticle formulations.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Peng
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Wei
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Shao
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Cai
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Lin
mesh_terms: D000818:Animals; D002417:Cattle; D003374:Coumarins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism*; D056951:Photoelectron Spectroscopy; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D003374:Coumarins; D004337:Drug Carriers; D012710:Serum Albumin, Bovine
keywords: albumin; drug release; in vivo distribution; metabolism; nanoparticles; protein corona; stability