title: Trypanosoma from rodents as potential source of infection in human-shaped landscapes of South-East Asia.
abstract: Reports of atypical human cases of Trypanosoma lewisi or T. lewisi-like and Trypanosoma evansi infections have increased in South-East Asia, urging to investigate the possible links between humans, animal reservoirs and habitats. We tested how habitat structure affects the infection by Trypanosoma species of common murine rodents, inhabiting human-dominated landscapes in South East Asia. For this, we used geo-referenced data of rodents investigated for Trypanosoma infection and land cover maps produced for seven study sites in Thailand, Cambodia and Lao PDR. High prevalence of infection by T. lewisi was observed in rodents living near human settlement and in areas with high cover of built-up habitat, while the infection of rodents by T. evansi was explained by increased landscape patchiness and high cover of rain-fed agriculture lands. These results suggest a likely role of wild rodents as reservoir and possible source of atypical human infection by animal trypanosomes.
authors.affiliation: Center for Agricultural Biotechnology, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand; Center of Excellence on Agricultural Biotechnology (AG-BIO/PERDO-CHE), Bangkok, Thailand; Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
authors.forename: Pornpan
authors.initials: P
authors.lastname: Pumhom
authors.affiliation: CIRAD, UPR Animal et Gestion Intégrée des Risques, F-34398 Montpellier, France; CNRS-CIRAD, Centre d'Infectiologie Christophe Mérieux du Laos, Vientiane, Lao Democratic People's Republic.
authors.forename: Serge
authors.initials: S
authors.lastname: Morand
authors.affiliation: CIRAD, UPR Animal et Gestion Intégrée des Risques, F-34398 Montpellier, France; CIRAD, UMR Territoires Environnement Télédétection et Information Spatiale, F-34093 Montpellier, France.
authors.forename: Annelise
authors.initials: A
authors.lastname: Tran
authors.affiliation: Center of Excellence on Agricultural Biotechnology (AG-BIO/PERDO-CHE), Bangkok, Thailand; Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. Electronic address: fvetspj@ku.ac.th.
authors.forename: Sathaporn
authors.initials: S
authors.lastname: Jittapalapong
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand; CIRAD-Bios, UMR17 InterTryp, Montpellier F-34000, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Desquesnes
mesh_terms: D000818:Animals; D002160:Cambodia / Q000453:epidemiology; D017753:Ecosystem; D006802:Human Activities; D006801:Humans; D007812:Laos / Q000453:epidemiology; D012376:Rodent Diseases / Q000453:epidemiology / Q000469:parasitology*; D012377:Rodentia; D013785:Thailand / Q000453:epidemiology; D014345:Trypanosoma / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014352:Trypanosomiasis / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary*
keywords: Habitat; Land cover; Rodents; Southeast Asia; Trypanosoma evansi; Trypanosoma lewisi