title: Data to knowledge: how to get meaning from your result.
abstract: Structural and functional studies require the development of sophisticated 'Big Data' technologies and software to increase the knowledge derived and ensure reproducibility of the data. This paper presents summaries of the Structural Biology Knowledge Base, the VIPERdb Virus Structure Database, evaluation of homology modeling by the Protein Model Portal, the ProSMART tool for conformation-independent structure comparison, the LabDB 'super' laboratory information management system and the Cambridge Structural Database. These techniques and technologies represent important tools for the transformation of crystallographic data into knowledge and information, in an effort to address the problem of non-reproducibility of experimental results.
authors.affiliation: Center for Integrative Proteomics Research, Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Berman
authors.affiliation: Center for Integrative Proteomics Research, Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Gabanyi
authors.affiliation: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, England.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Groom
authors.affiliation: Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Johnson
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
authors.forename: Garib N
authors.initials: GN
authors.lastname: Murshudov
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Nicholls
authors.affiliation: Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Reddy
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056 Basel, Switzerland ; SIB-Swiss Institute of Bioinformatics, Basel, Switzerland.
authors.forename: Torsten
authors.initials: T
authors.lastname: Schwede
authors.affiliation: Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Zimmerman
authors.affiliation: Center for Integrative Proteomics Research, Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.
authors.forename: John
authors.initials: J
authors.lastname: Westbrook
authors.affiliation: Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
authors.forename: Wladek
authors.initials: W
authors.lastname: Minor
keywords: big data; data deposition; databases; knowledge bases; meaning from data