title: [Reinforcement of warfarin action in a patient administered S-1].
abstract: A case showing reinforcement of the action of warfarin and potassium in a patient administered S-1 is reported.The patient was a 71-year-old man with left upper gingival cancer.He had ventricular tachycardia (VT), hypertrophic cardiomyopathy, and a cerebellar infarction.He underwent a pacemaker implantation, and was administered warfarin.After the operation, in mid-March 2010, he was administered with S-1 and warfarin. However, the international normalized ratio of prothrombin time (PT-INR) increased to an extremely high level of 5.82, and S-1 and warfarin were stopped. They were re-administered at the end of April, and the PT-INR stabilized to approximately 2.
authors.affiliation: Dept. of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University.
authors.forename: Hideki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Hiroto
authors.initials: H
authors.lastname: Itoh
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Norito
authors.initials: N
authors.lastname: Miyagi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nakai
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinozaki
authors.forename: Tadahide
authors.initials: T
authors.lastname: Noguchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Jinbu
authors.forename: Mikio
authors.initials: M
authors.lastname: Kusama
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000188:drug therapy*; D002544:Cerebral Infarction / Q000150:complications / Q000188:drug therapy*; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000150:complications / Q000188:drug therapy*; D018307:Neoplasms, Squamous Cell / Q000150:complications / Q000188:drug therapy*; D010094:Oxonic Acid / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000150:complications / Q000188:drug therapy*; D005641:Tegafur / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D014859:Warfarin; D010094:Oxonic Acid