title: Prophylactic vitamin D supplementation in ovarian hyperstimulation syndrome: an animal study.
abstract: OBJECTIVE
  To investigate the effect of vitamin D in ovarian hyperstimulation syndrome (OHSS).
  
  
  METHODS
  In this animal study, 28 immature female Wistar rats were divided into four groups: group 1 (control); group 2 (ovarian stimulation); group 3 (OHSS group); group 4 (OHSS + vitamin D group). All groups were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight, ovarian diameter, vascular endothelial growth factor (VEGF) expression (immunohistochemistry) in ovarian tissue and pigment epithelium-derived factor (PEDF) level in the serum (ELISA test) with the Kruskal-Wallis and Mann-Whitney U tests.
  
  
  RESULTS
  VEGF expression in the vitamin D group was similar to that in the OHSS group. However, the PEDF level was significantly higher in the vitamin D group (p = 0.013).
  
  
  CONCLUSIONS
  Prophylactic vitamin D supplementation is not sufficiently effective in preventing OHSS. Vitamin D effectively increases PEDF, which has an opposing effect on VEGF, which plays a key role in OHSS. Thus, the protective effect of Vitamin D on OHSS should be investigated with a vitamin D deficient model in the study group.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, Sifa University, Sanayi cad no:7, Bornova, 35100, Izmir, Turkey, arzuturan74@yahoo.com.
authors.forename: Guluzar Arzu
authors.initials: GA
authors.lastname: Turan
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskicioglu
authors.forename: Oya Nermin
authors.initials: ON
authors.lastname: Sivrikoz
authors.forename: Hakan
authors.initials: H
authors.lastname: Cengiz
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.forename: Sumeyra
authors.initials: S
authors.lastname: Tatar
authors.forename: Nur
authors.initials: N
authors.lastname: Sahin
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000097:blood / Q000378:metabolism*; D009929:Organ Size; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010062:Ovulation Induction; D051381:Rats; D017208:Rats, Wistar; D015843:Serpins / Q000097:blood / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism*; D014807:Vitamin D / Q000008:administration & dosage* / Q000494:pharmacology; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D042461:Vascular Endothelial Growth Factor A; D014807:Vitamin D; D000099174:Pigment Epithelium-Derived Factor