title: The use of BMP-2 and screw exchange in the treatment of scaphoid fracture non-union.
abstract: Scaphoid non-union, particularly following internal fixation, is a vexing problem. A retrospective review was conducted analysing the outcome of 4 patients who failed initial open reduction and internal fixation of scaphoid fractures. Three fractures were located in the waist and the fourth in the proximal pole. All patients underwent screw exchange and Bone Morphogenic Protein (BMP)-2 sponge placement with no additional bone grafting. Patients were immobilised for 4 weeks and followed with serial radiographs in all cases and CT scans in 3 cases. All patients demonstrated evidence of bony union at an average of 53 days from surgery and ultimately returned to pain-free full activity. There were no complications. BMP-2 and screw exchange yielded a 100% union rate in patients with established scaphoid non-union. While this retrospective study represents a small number of patients and clearly requires further investigation, it presents a promising technique for managing a difficult clinical problem.
authors.affiliation: Department of Orthopaedics and Sports Medicine, University at Buffalo, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Ablove
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Abrams
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D001863:Bone Screws; D016025:Bone Transplantation; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods*; D017102:Fracture Healing; D005599:Fractures, Ununited / Q000601:surgery*; D006801:Humans; D012086:Reoperation; D012189:Retrospective Studies; D021361:Scaphoid Bone / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D055396:Bone Morphogenetic Protein 2
keywords: BMP-2; Bone Morphogenic Protein; Non-Union; Scaphoid