title: Real-world effect of gastroesophageal reflux disease on cough-related quality of life and disease status in asthma and COPD.
abstract: BACKGROUND
  Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and often coexists with asthma or chronic obstructive pulmonary disease (COPD); however, it is unknown whether there are differences in the effect of GERD on these diseases. The purpose of this study was to assess the difference in the effect of GERD on cough-related quality of life and disease status in asthma and COPD in a real-world setting.
  
  
  METHODS
  Subjects were 132 patients with overall controlled asthma and 102 patients with stable COPD. They completed the frequency scale for symptoms of GERD (FSSG), a validated Japanese questionnaire for GERD, the Leicester Cough Questionnaire (LCQ), and the Asthma Control Test (ACT) or COPD assessment test (CAT) questionnaires.
  
  
  RESULTS
  We found that 29 (22.0%) patients with asthma and 22 (21.6%) patients with COPD had GERD. There was no difference in the FSSG scale between the diseases. The patients with GERD, regardless of having asthma or COPD, had lower LCQ scores affecting all health domains and lower ACT or higher CAT scores than those without GERD. Overall, the patients with COPD had lower LCQ scores regardless of the presence or absence of GERD. The FSSG scale was negatively correlated with the LCQ total score in asthma and in COPD. In contrast, the FSSG scale was positively correlated with the CAT score but not with the ACT score.
  
  
  CONCLUSIONS
  Patients with GERD had impaired cough-related quality of life, poor asthma control or more symptoms and impacts of COPD.
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan. Electronic address: toshihiro-shirai@i.shizuoka-pho.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shirai
authors.affiliation: Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Mikamo
authors.affiliation: Department of Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Tsuchiya
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Shishido
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Akita
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Asada
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.affiliation: Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D015897:Comorbidity; D003371:Cough / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000503:physiopathology; D011788:Quality of Life; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Asthma; Chronic obstructive pulmonary disease; Cough; Gastroesophageal reflux disease; Questionnaire