title: Change of regional choroid thickness after reduced-fluence photodynamic therapy for chronic central serous chorioretinopathy.
abstract: OBJECTIVE
  To evaluate macular choroidal thickness after reduced-fluence photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC).
  
  
  METHODS
  Prospective, consecutive, interventional case series.
  
  
  METHODS
  Twenty-two eyes with chronic CSC were treated with reduced-fluence PDT. Macular choroidal thickness was examined using spectral-domain optical coherence tomography with a 3-dimensinonal radial scan protocol in the choroidal mode before and 1, 3, and 6 months after the treatment. The mean choroidal thickness in the Early Treatment Diabetic Retinopathy Study grid (center, inner circle, and outer circle) was compared between before and after therapy, as well as between treated eyes and 54 volunteer normal eyes.
  
  
  RESULTS
  Chronic CSC eyes showed significantly thicker choroids in the macular area compared with normal controls (P < .0001). After the single treatment session, subretinal fluid resolved completely in all eyes, and there were no recurrences during the study period. Choroidal thickness within the center area and inner circle showed a significant reduction at all time points after treatment (P < .05). The choroidal thickness in the outer circle showed a statistically significant reduction at 1 and 3 months but not at 6 months. After treatment, the choroidal thickness reduced to the normal values at the center and inner circle, but was still significantly thicker in the outer circle (P < .01).
  
  
  CONCLUSIONS
  Chronic CSC eyes showed significantly thicker choroids in the macular area. After reduced-fluence PDT, macular choroidal thickness became thinner within 6 months of treatment.
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Manabe
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan. Electronic address: chappi@kms.ac.jp.
authors.forename: Chieko
authors.initials: C
authors.lastname: Shiragami
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hirooka
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Izumibata
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
authors.forename: Akitaka
authors.initials: A
authors.lastname: Tsujikawa
authors.affiliation: Department of Ophthalmology, Okayama University, Okayama, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Shiraga
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy*; D002829:Choroid / Q000473:pathology*; D002908:Chronic Disease; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D017319:Photosensitizing Agents; D007208:Indocyanine Green