title: A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
abstract: We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation. All data are available and searchable at http://www.mouseac.org.
authors.affiliation: Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK; Reta Lila Research Laboratories and Department of Molecular Neuroscience, UCL, Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK.
authors.forename: Mar
authors.initials: M
authors.lastname: Matarin
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Dervis A
authors.initials: DA
authors.lastname: Salih
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Marina
authors.initials: M
authors.lastname: Yasvoina
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Damian M
authors.initials: DM
authors.lastname: Cummings
authors.affiliation: Reta Lila Research Laboratories and Department of Molecular Neuroscience, UCL, Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Guelfi
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK; Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Muzammil A
authors.initials: MA
authors.lastname: Nahaboo Solim
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Moens
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Rocio Moreno
authors.initials: RM
authors.lastname: Paublete
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Shabinah S
authors.initials: SS
authors.lastname: Ali
authors.affiliation: Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Marina
authors.initials: M
authors.lastname: Perona
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Roshni
authors.initials: R
authors.lastname: Desai
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Smith
authors.affiliation: Department of Laboratory Animal Science, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
authors.forename: Judy
authors.initials: J
authors.lastname: Latcham
authors.affiliation: Department of Laboratory Animal Science, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Fulleylove
authors.affiliation: Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
authors.forename: Jill C
authors.initials: JC
authors.lastname: Richardson
authors.affiliation: Reta Lila Research Laboratories and Department of Molecular Neuroscience, UCL, Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK. Electronic address: j.hardy@ucl.ac.uk.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, UCL, Gower Street, London WC1E 6BT, UK. Electronic address: f.a.edwards@ucl.ac.uk.
authors.forename: Frances A
authors.initials: FA
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003704:Dementia / Q000378:metabolism; D005786:Gene Expression Regulation; D055106:Genome-Wide Association Study; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D016875:tau Proteins