title: Synthesis and characterization of water-soluble, heteronuclear ruthenium(III)/ferrocene complexes and their interactions with biomolecules.
abstract: The reaction of Na[RuCl4(SO(CH3)2)2], 1, with one equivalent of FcCONHCH2C6H4N (Fc=FeC10H9), L1, FcCOOCH2CH2C3H3N2, L2, FcCOOC6H4N, L3, afforded the dinuclear species, Na[FcCONHCH2C6H4N[RuCl4(SO(CH3)2)]], RuL1, Na[FcCOOCH2CH2C3H3N2[RuCl4(SO(CH3)2)]], RuL2, Na[FcCOOC6H4N(RuCl4(SO(CH3)2))], RuL3, respectively, yielding, in each case, a ferrocene moiety bridged to a ruthenium center. The complexes were characterized by NMR, IR, and XRD (X-ray diffraction). The sulfoxide ligands are bonded to the metal through the sulfur atom. The complexes were evaluated for their biological activity with pBluescript DNA plasmid, and the protein BSA (bovine serum albumin). These reactions were monitored by XAS (X-ray absorption spectroscopy), EXAFS (extended X-ray Absorption Fine Structure), NMR, UV/visible, emission spectroscopy, and gel electrophoresis. Donor atoms from the biomolecules substitute for the chloride ligands in the parent complexes.
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA. Electronic address: canderso@bard.edu.
authors.forename: Craig M
authors.initials: CM
authors.lastname: Anderson
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Swapan S
authors.initials: SS
authors.lastname: Jain
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Silber
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Kody
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Sumedha
authors.initials: S
authors.lastname: Guha
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Wancong
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Rd, Annandale-on-Hudson, NY 12504, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: McLaughlin
authors.affiliation: Canadian Light Source, 101 Perimeter Road, Saskatoon, SK S7N 0X4, Canada.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Vassar College, 124 Raymond Avenue, Box 601, Poughkeepsie, NY 12604, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Tanski
mesh_terms: D004247:DNA / Q000737:chemistry*; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D000075163:Metallocenes; D008958:Models, Molecular; D017975:Ruthenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012995:Solubility; D013057:Spectrum Analysis / Q000379:methods; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D005296:Ferrous Compounds; D000075163:Metallocenes; D017975:Ruthenium Compounds; D014867:Water; D012710:Serum Albumin, Bovine; D004247:DNA; C004998:ferrocene
keywords: Cancer; Ferrocene; NMR; Paramagnetic; Ruthenium