title: Use of medications and functional dependence among Chinese older adults in a rural community: A population-based study.
abstract: OBJECTIVE
  To investigate the associations between medication use and functional dependence in Chinese older people living in a rural community.
  
  
  METHODS
  The cross-sectional study included 1538 participants (age ≥60 years, 59.1% women) in the Confucius Hometown Aging Project in Shandong, China. In June 2010 to July 2011, data on demographics, lifestyle factors, health history, basic activities of daily living (ADL), instrumental ADL, and use of medications were collected through interviews and clinical examinations. Functional status was categorized into no dependence, dependence only in instrumental ADL and dependence in basic ADL. Data were analyzed with multinomial logistic models controlling for potential confounders.
  
  
  RESULTS
  Dependence in instrumental or basic ADL was significantly associated with use of antihypertensives and hypolipidemic agents, and basic ADL dependence was also associated with use of sedatives or tranquilizers and cardiac glycosides. An increased number of concurrently used medications was significantly associated with an increased likelihood of dependence in basic ADL (P for trend = 0.016). Compared with non-users of any medication, individuals who concurrently used three or more classes of medications had a multi-adjusted odds ratio of 2.91 (95% confidence interval 1.02-8.28) for dependence in basic ADL.
  
  
  CONCLUSIONS
  Use of antihypertensives, hypolipidemic drugs, cardiac glycosides and sedatives or tranquilizers, especially use of multiple classes of medications, is correlated with functional dependence among older people in rural China. Geriatr Gerontol Int 2015; 15: 1242-1248.
authors.affiliation: School of Public Health, Jining Medical University, Jining, China.|Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University.
authors.forename: Kristina
authors.initials: K
authors.lastname: Johnell
authors.affiliation: Department of Neurology, Jining no. 1 People's Hospital, Jining, China.
authors.forename: Zhongrui
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Xing Long Zhuang Coal Mine Hospital, Yankuang Group, Jining, China.
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Cai
authors.affiliation: Xing Long Zhuang Coal Mine Hospital, Yankuang Group, Jining, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University.|Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Welmer
authors.affiliation: Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University.
authors.forename: Chengxuan
authors.initials: C
authors.lastname: Qiu
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities / Q000534:rehabilitation / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012424:Rural Population
chemical_list: D002317:Cardiovascular Agents
keywords: China; functional dependence; medications; old age; population study