title: The response of hepatitis B vaccination on seronegative adults with different vaccination schedules.
abstract: The purpose of this study was to compare the response of hepatitis B vaccination with different vaccination schedules among seronegative adults, and to provide suitable vaccination schedules for floating and fixed population. The study included adults aged 20 to 39 y without prior history of vaccination with hepatitis B vaccine. The serum samples were collected and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels. Out of all, 686 adults who were negative for anti-HBs, anti-HBc and HBsAg were vaccinated with 10 ug hepatitis B vaccine at 0, 1 and 3, 6 or 12 month schedules, and their antibody titers were monitored. The rates of completion of the vaccination in floating and fixed population were 90.4% and 94.1% respectively (p = 0.061). The anti-HBs positive rates in adults vaccinated at 0, 1 and 3 ,6 or 12 month were 83.9%, 88.2% and 94.2% respectively (P = 0.0003). The corresponding geometric mean titers (GMTs) were 61.19 (95%CI:47.10-81.23) mIU/mL, 214.04(95%CI:157.14-291.61) mIU/mL and 345.78(95%CI:251.25-475.77) mIU/mL, respectively ( P < 0.0001). Vaccination of hepatitis B with both 0-1-6 and 0-1-12 month schedules in adults result in better level of immune responses. Also, a longer vaccination schedule (0-1-12 month) may be more suitable for floating population and 0-1-6 month schedule is recommended for the fixed population.
authors.affiliation: a Zhejiang Provincial Center for Disease Control and Prevention ; Hangzhou , Zhejiang , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yongdi
authors.initials: Y
authors.lastname: Chen
authors.forename: Huan
authors.initials: H
authors.lastname: Shan
authors.forename: Xue-wei
authors.initials: XW
authors.lastname: Dai
authors.forename: Lin-na
authors.initials: LN
authors.lastname: Yang
authors.forename: Zheng-gang
authors.initials: ZG
authors.lastname: Jiang
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Ren
authors.forename: Kai-jin
authors.initials: KJ
authors.lastname: Xu
authors.forename: Bing
authors.initials: B
authors.lastname: Ruan
authors.forename: Shi-gui
authors.initials: SG
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Tian-sheng
authors.initials: TS
authors.lastname: Xie
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D014611:Vaccination / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: China; Hepatitis B vaccine; adults; immunization