title: Depression status as a predictor of quit success in a real-world effectiveness study of nicotine replacement therapy.
abstract: To provide population-level evidence of the role of current depression on smoking cessation treatment success, we conducted a secondary analysis of data obtained from a large cessation study conducted in over 13,000 smokers. On the basis of self-reported history of depression diagnoses at baseline, participants were divided into four mutually exclusive groups: current/recent depression, recurrent depression, past depression and no depression history. Cessation outcomes were compared among the four groups at 6-month follow-up. Of the 6261 individuals who were consented and attempted to be contacted for follow-up, 4648 (74.2%) had no diagnostic history of depression, 591 (9.4%) had a past history of depression, 759 (12.1%) had a current/recent depression diagnoses, and 263 (4.2%) had recurrent depression (both current and history). Those with recurrent depression were significantly less likely to quit smoking compared to those with no history of depression. In unadjusted analyses, recurrent depression was associated with significantly lower odds of quitting compared to those with either no history or a past history of depression. Current/recent depression was also associated with poorer quit outcomes compared to those with no history of depression. Depressed smokers may benefit from more individualized, in-person approaches to smoking cessation.
authors.affiliation: Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, 175 College Street, Toronto, Ontario, Canada M5T 1P7; Department of Pharmacology and Toxicology, University of Toronto, 1 King׳s College Circle, Toronto, Ontario, Canada M5S 1A8. Electronic address: laurie.zawertailo@camh.ca.
authors.forename: Laurie
authors.initials: L
authors.lastname: Zawertailo
authors.affiliation: Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, 175 College Street, Toronto, Ontario, Canada M5T 1P7.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Voci
authors.affiliation: Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, 175 College Street, Toronto, Ontario, Canada M5T 1P7; Department of Family and Community Medicine and Psychiatry, University of Toronto, 500 University Avenue, Toronto, Ontario, Canada M5G 1V7; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7.
authors.forename: Peter
authors.initials: P
authors.lastname: Selby
mesh_terms: D000328:Adult; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D003865:Major Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000628:therapy; D016540:Smoking Cessation / Q000379:methods / Q000523:psychology*; D061485:Tobacco Use Cessation Devices; D014029:Tobacco Use Disorder / Q000188:drug therapy
keywords: Depression; Nicotine replacement therapy; Smoking; Tobacco dependence; Treatment