title: Role of E3 ubiquitin ligases in gastric cancer.
abstract: E3 ubiquitin ligases have an important role in carcinogenesis and include a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome. So far, E3 ubiquitin ligases have been reported to have a role in a variety of biological processes including cell cycle regulation, cell proliferation, and apoptosis. Recently, several kinds of E3 ubiquitin ligases were demonstrated to be generally highly expressed in gastric cancer (GC) tissues and to contribute to carcinogenesis. In this review, we summarize the current knowledge and information about the clinical significance of E3 ubiquitin ligases in GC. Bortezomib, a proteasome inhibitor, encouraged the evaluation of other components of the ubiquitin proteasome system for pharmaceutical intervention. The clinical value of novel treatment strategies targeting aberrant E3 ubiquitin ligases for GC are discussed in the review.
authors.affiliation: Ya-Chao Hou, Jing-Yu Deng, Department of Gastroenterology, Cancer Hospital of Tianjin Medical University, City Key Laboratory of Tianjin Cancer Center, and National Clinical Research Center of Cancer, Tianjin 300060, China.
authors.forename: Ya-Chao
authors.initials: YC
authors.lastname: Hou
authors.affiliation: Ya-Chao Hou, Jing-Yu Deng, Department of Gastroenterology, Cancer Hospital of Tianjin Medical University, City Key Laboratory of Tianjin Cancer Center, and National Clinical Research Center of Cancer, Tianjin 300060, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Deng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D044767:Ubiquitin-Protein Ligases
keywords: E3 ubiquitin ligases; Gastric cancer; Oncogene; Target therapy; Tumor suppressor gene