title: Function of CD147 in atherosclerosis and atherothrombosis.
abstract: CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu province, People's Republic of China, 212001.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Jin
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhu
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Yan
authors.forename: Guohong
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D051926:Basigin / Q000276:immunology / Q000378:metabolism*; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism; D001808:Blood Vessels / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D018384:Oxidative Stress; D058226:Plaque, Atherosclerotic; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D013927:Thrombosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D011956:Receptors, Cell Surface; D051926:Basigin