title: Clinical evaluation of a cross-linked hyaluronic Acid dermal filler applied for facial augmentation.
abstract: BACKGROUND
  Hyaluronic Acid (HA) fillers are widely used for restoring facial volume.
  
  
  OBJECTIVE
  A 24-week study evaluated clinical efficacy with HA.
  
  
  METHODS
  Included were 15 healthy subjects recruited from 4 centers, between ages of 35 to 65 years, who had a Wrinkle Severity Rating Scale (WSRS) score ≥ 3, indicating moderate volume loss. Revanesse® Ultra (Prollenium), a HA dermal filler, was used. Primary study outcome was physicians scored facial volume correction, using the Global Aesthetic Improvement Scale (GAIS), comparing baseline (day 0) versus 24 weeks (end) and blindly assessed photographs. Subject satisfaction and comfort was evaluated using self-administered questionnaires at day 0 and at week 24.
  
  
  RESULTS
  N = 15, 13 female and 2 males with a mean age (years) of 48.52 ( SD ± 10.46) received treatment with HA and completed the 24-week study. At screening they had a moderate (mean 2.85, SD ± 0.45) WSRS score. At week 24 a market facial volume restoration was shown and no adverse events were reported. All patients reported to be satisfied with the obtained results.
  
  
  CONCLUSIONS
  Good - excellent volume enhancement was noted almost immediately after the HA injections, improving patient reported quality of life aspects. HA treatment was shown to be safe.
authors.forename: Scott Km
authors.initials: SK
authors.lastname: Barr
authors.forename: Arie
authors.initials: A
authors.lastname: Benchetrit
authors.forename: Mariusz
authors.initials: M
authors.lastname: Sapijaszko
authors.forename: Anneke
authors.initials: A
authors.lastname: Andriessen
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques / Q000009:adverse effects; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011788:Quality of Life; D015595:Skin Aging / Q000187:drug effects*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid