title: Proteomics: in pursuit of effective traumatic brain injury therapeutics.
abstract: Effective traumatic brain injury (TBI) therapeutics remains stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived. Future research must confront the multitude of factors comprising this heterogeneity, representing a big data challenge befitting the coming informatics age. Proteomics is poised to serve a central role in prescriptive therapeutic development because it offers an efficient endpoint within which to assess post-TBI biochemistry. We examine rationale for multifactor TBI proteomic studies and the particular importance of temporal profiling in defining biochemical sequences and guiding therapeutic development. Finally, we offer perspective on repurposing biofluid proteomics to develop theragnostic assays with which to prescribe, monitor and assess pharmaceutics for improved translation and outcome for patients with TBI.
authors.affiliation: Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
authors.forename: Pavel N
authors.initials: PN
authors.lastname: Lizhnyak
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Ottens
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001930:Brain Injuries / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D020543:Proteome / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D018696:Neuroprotective Agents; D020543:Proteome
keywords: TBI; brain injury; informatics; inhibitory synapses; post-translational modification; proteomics; temporal; theragnostics; therapeutics