title: The problems of replication in the early stages of evolution: enumeration of variants and spatial configurations of replicators.
abstract: Two main problems of replication in the early stages of evolution are discussed: the problem of exponentially large number of conformational degrees of freedom and the problem of enumeration of variants.
authors.affiliation: Ural Federal University, Mira str. 19, Yekaterinburg, Russia, melkikh2008@rambler.ru.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Melkikh
mesh_terms: D004261:DNA Replication; D019020:Directed Molecular Evolution; D019143:Evolution, Molecular; D059646:Genome Size; D007257:Information Theory; D008954:Models, Biological; D008968:Molecular Conformation; D000069497:Origin of Life; D011789:Quantum Theory