title: [Effect of red maca (Lepidium meyenii) on INF-γ levels in ovariectomized rats].
abstract: OBJECTIVE
  Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX).
  
  
  METHODS
  Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively.
  
  
  RESULTS
  OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05).
  
  
  CONCLUSIONS
  Red maca administration increases levels of IFN-γ in ovariectomized rats.
authors.affiliation: Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Johanna
authors.initials: J
authors.lastname: Leiva-Revilla
authors.affiliation: Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Félix
authors.initials: F
authors.lastname: Guerra-Castañon
authors.affiliation: Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Paola
authors.initials: P
authors.lastname: Olcese-Mori
authors.affiliation: Laboratorio de Inmunología, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Iván
authors.initials: I
authors.lastname: Lozada
authors.affiliation: Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Julio
authors.initials: J
authors.lastname: Rubio
authors.affiliation: Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Carla
authors.initials: C
authors.lastname: Gonzales
authors.affiliation: Laboratorio de Endocrinología y Reproducción, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Gonzales
mesh_terms: D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000097:blood* / Q000187:drug effects*; D029686:Lepidium; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D007371:Interferon-gamma