title: Diagnosis and management of type II myocardial infarction: increased demand for a limited supply of evidence.
abstract: Type 2 myocardial infarction (type 2 MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand. Although type 2 MI is highly prevalent and strongly associated with mortality, the pathophysiology remains poorly understood. Discrepancies in definitions, frequency of screening, diagnostic approaches, and methods of adjudication lead to confusion and misclassification. To date, there is no consensus on the diagnostic criteria for type 2 MI. No guidelines exist for the optimal management of this condition, and further investigation is urgently needed. This review explores the existing evidence on the pathophysiology, diagnosis, prognosis, and management of type 2 MI.
authors.affiliation: Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Smilowitz
authors.forename: Becky
authors.initials: B
authors.lastname: Naoulou
authors.forename: Steven P
authors.initials: SP
authors.lastname: Sedlis
mesh_terms: D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D019210:Troponin I