title: Protective host immune responses to Salmonella infection.
abstract: Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host-pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis. This review will focus on our current understanding of Salmonella pathogenesis and the major host immune components that participate in immunity to Salmonella infection. In addition, recent findings regarding host immune mechanisms in response to Salmonella infection will be also discussed, providing a new perspective on the utility of improved tools to study the immune response to Salmonella infections.
authors.affiliation: Center for Comparative Medicine, Department of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
authors.forename: Oanh H
authors.initials: OH
authors.lastname: Pham
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: McSorley
mesh_terms: D054884:Host-Pathogen Interactions; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D012480:Salmonella Infections / Q000276:immunology*; D019779:Salmonella enterica / Q000276:immunology* / Q000472:pathogenicity; D014435:Typhoid Fever / Q000276:immunology*
keywords: B cells; CD4 T cells; bacterial infection; immunity; protection