title: Peripartum anesthetic management of a parturient with inherited factor v deficiency.
abstract: Inherited Factor V deficiency is a rare bleeding disorder. We describe the genetic analysis and anesthetic management of a parturient with severe Factor V deficiency who presented in spontaneous labor. Good hemostatic conditions were obtained with prophylactic fresh frozen plasma administration of 10 mL/kg. Detailed genetic analysis by next-generation sequencing identified several relevant mutations in the coding part of the Factor V (F5) gene in our patient, her parents, and the newborn.
authors.affiliation: From the Department of Anaesthesiology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Sonia
authors.initials: S
authors.lastname: Vaida
authors.forename: Hamid
authors.initials: H
authors.lastname: Al-Mondhiry
authors.forename: Dmitri
authors.initials: D
authors.lastname: Bezinover
authors.forename: Lauren
authors.initials: L
authors.lastname: Welsh
authors.forename: Serdar
authors.initials: S
authors.lastname: Ural
authors.forename: Piotr
authors.initials: P
authors.lastname: Janicki