title: Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement.
abstract: OBJECTIVE
  To describe a rare case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with morphologic and immunophenotypic evidence of bone marrow involvement.
  
  
  METHODS
  Biopsy specimens of skin and subcutis and bone marrow were examined using H&E-stained sections. Immunohistochemical studies for CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, CD56, and granzyme B were reviewed. In addition, T-cell receptor γ gene rearrangement studies were performed.
  
  
  RESULTS
  A bone marrow core biopsy demonstrated several lymphohistiocytic aggregates containing atypical, cytotoxic T cells that rimmed adipocytes and were associated with karyorrhexis. These T cells were morphologically and immunophenotypically identical to a concurrent SPTCL, expressing CD2, CD3, CD7, CD8, and granzyme B but with diminished CD5 expression.
  
  
  CONCLUSIONS
  SPTCL may rarely involve the bone marrow. Bone marrow infiltrates show a similar morphologic and immunophenotypic appearance to those in the subcutaneous fibroadipose tissue, including rimming of adipocytes by neoplastic lymphocytes.
authors.affiliation: From the Departments of Pathology.
authors.forename: Noah A
authors.initials: NA
authors.lastname: Brown
authors.affiliation: From the Departments of Pathology.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Ross
authors.affiliation: Dermatology.
authors.forename: Johann E
authors.initials: JE
authors.lastname: Gudjonsson
authors.affiliation: Radiology, and.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wale
authors.affiliation: Internal Medicine, and.
authors.forename: Attaphol
authors.initials: A
authors.lastname: Pawarode
authors.affiliation: Internal Medicine, and Life Sciences Institute, University of Michigan, Ann Arbor.
authors.forename: Ivan
authors.initials: I
authors.lastname: Maillard
authors.affiliation: From the Departments of Pathology, Dermatology, ahristov@med.umich.edu.
authors.forename: Alexandra C
authors.initials: AC
authors.lastname: Hristov
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D015434:Panniculitis / Q000276:immunology / Q000473:pathology*
keywords: Atypical lymphocytic lobular panniculitis; Bone marrow involvement; Hemophagocytic syndrome; Lupus panniculitis; Subcutaneous panniculitis-like T-cell lymphoma