title: Spatial gradients controlling spindle assembly.
abstract: The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.
authors.affiliation: *Department of Biology, Indiana University, Bloomington, IN 47405, U.S.A.
authors.forename: Lesley N
authors.initials: LN
authors.lastname: Weaver
authors.affiliation: †Medical Sciences, Indiana University, Bloomington, IN 47405, U.S.A.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Walczak
mesh_terms: D000818:Animals; D020090:Chromosome Segregation; D002875:Chromosomes / Q000502:physiology; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D055503:Protein Multimerization; D021381:Protein Transport; D008941:Spindle Apparatus / Q000378:metabolism*