title: Cardiometabolic Profile Related to Body Adiposity Identifies Patients Eligible for Bariatric Surgery More Accurately than BMI.
abstract: BACKGROUND
  Eligibility criteria for bariatric surgery (BS) are based on BMI and the presence of major comorbidities. Our aim was to analyze the usefulness of body adiposity determination in establishing the indication for BS.
  
  
  METHODS
  In order to analyze the cardiometabolic risk according to eligibility criteria for BS, four groups were studied. Morbidly obese patients with BMI ≥ 40 kg/m(2) (n = 360), and obese subjects with BMI ≥ 35 kg/m(2) and at least one comorbidity (n = 431), represented two groups of patients meeting original NIH criteria for BS. A third group included two cohorts of patients with a high body fat (BF)% that do not meet the original NIH eligibility criteria for BS: patients with either a BMI <35 kg/m(2) or a BMI ≥ 35 kg/m(2) without comorbidities (n = 266, NEHF). Lean subjects by BMI were the reference group (n = 140). BMI, BF% and markers of insulin sensitivity, lipid profile, and cardiovascular risk were measured.
  
  
  RESULTS
  Individuals from the NEHF group exhibited increased HbA1c (P < 0.05) and decreased insulin sensitivity evidenced by a significant reduction in QUICKI (P < 0.001). Triglyceride concentrations were similarly increased (P < 0.05) in the three groups of obese patients. Uric acid concentrations were significantly elevated (P < 0.01) to a similar extent in the obese groups. Levels of the inflammatory marker CRP and hepatic enzymes were significantly increased in the three obese groups.
  
  
  CONCLUSIONS
  The present study provides evidence for the existence of an adverse cardiometabolic profile in subjects currently considered to be outside traditional NIH guidelines but exhibiting a highly increased adiposity. It is concluded that body composition analysis yields valuable information to be incorporated into indication criteria for BS and that adiposity may be an independent indicator for BS.
authors.affiliation: Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008, Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez-Ambrosi
authors.forename: Rafael
authors.initials: R
authors.lastname: Moncada
authors.forename: Víctor
authors.initials: V
authors.lastname: Valentí
authors.forename: Camilo
authors.initials: C
authors.lastname: Silva
authors.forename: Beatriz
authors.initials: B
authors.lastname: Ramírez
authors.forename: Victoria
authors.initials: V
authors.lastname: Catalán
authors.forename: Amaia
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Patricia
authors.initials: P
authors.lastname: Andrada
authors.forename: Javier
authors.initials: J
authors.lastname: Escalada
authors.forename: Carlos
authors.initials: C
authors.lastname: Pastor
authors.forename: Javier A
authors.initials: JA
authors.lastname: Cienfuegos
authors.forename: María J
authors.initials: MJ
authors.lastname: Gil
authors.forename: Javier
authors.initials: J
authors.lastname: Salvador
authors.forename: Gema
authors.initials: G
authors.lastname: Frühbeck
mesh_terms: D050154:Adiposity; D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000032:analysis
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D014280:Triglycerides; D014527:Uric Acid; C517652:hemoglobin A1c protein, human