title: The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells.
abstract: The traditional Chinese medicinal formula BDL301 has been used to inhibit inflammation for hundreds of years. The development of colorectal cancer and chronic inflammation are closely related. In this study, we investigated whether BDL301 could inhibit tumor growth. We found that angiogenesis and tumor growth were both inhibited in vivo. In addition, apoptosis was induced and the signal transducer and activator of transcription-3 (STAT3) pathway were suppressed in the colorectal cancer cells in vitro and in vivo by BDL301. This study demonstrates that BDL301 exerted significant anticancer activity by inhibiting the STAT3 pathways and inducing apoptosis in colorectal cancer cells.
authors.affiliation: 1 Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University , School of Medicine, Shanghai, China .
authors.forename: Li
authors.initials: L
authors.lastname: Chu
authors.forename: Huaxin
authors.initials: H
authors.lastname: Zhao
authors.forename: Juemin
authors.initials: J
authors.lastname: Fang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Cui
authors.forename: Fei
authors.initials: F
authors.lastname: Hu
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Yijing
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D045325:HCT116 Cells; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008516:Medicine, Chinese Traditional; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D051996:Transcription Factor RelA / Q000378:metabolism; D047368:Tumor Burden / Q000187:drug effects
chemical_list: C000597031:BDL301; D004365:Drugs, Chinese Herbal; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D050796:STAT3 Transcription Factor; D051996:Transcription Factor RelA