title: Evaluation of halogenated coumarins for antimosquito properties.
abstract: Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.
authors.affiliation: Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia ; Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa.
authors.forename: Venugopala K
authors.initials: VK
authors.lastname: Narayanaswamy
authors.affiliation: CREAN-IMBIV (CONICET-UNC), Facultad de Ciencias Agropecuarias, and FCEFyN, Universidad Nacional de Córdoba, Avenida Valparaíso s/n, 5016 Córdoba, Argentina.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Gleiser
authors.affiliation: Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa.
authors.forename: Kabange
authors.initials: K
authors.lastname: Kasumbwe
authors.affiliation: Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
authors.forename: Bandar E
authors.initials: BE
authors.lastname: Aldhubiab
authors.affiliation: Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
authors.forename: Mahesh V
authors.initials: MV
authors.lastname: Attimarad
authors.affiliation: Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa.
authors.forename: Bharti
authors.initials: B
authors.lastname: Odhav
mesh_terms: D000818:Animals; D000852:Anopheles; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007302:Insect Repellents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D058751:Livestock; D009032:Mosquito Control
chemical_list: D003374:Coumarins; D007302:Insect Repellents; D007306:Insecticides