title: HPC-A dose prediction on the optia® cell separator based on a benchmark CE2 collection efficiency: Promoting clinical efficiency, minimizing toxicity, and allowing quality control.
abstract: It has been shown that it is possible to predict the CD 34+ hematopoietic progenitor cell dose from collection procedures on TerumoBCT COBE Spectra® cell separator platform using simple variables available at the start of the procedure. In this article, we demonstrate that this can be done simply and reliably using TerumoBCT Spectra Optia® ("Optia") cell separator platform with a very close correlation between predicted and actual results (correlation coefficient 0.956). This knowledge can be used to optimize apheresis sessions and to minimize harmful effects and costs. In addition, we have shown differences in collection efficiency between healthy donors and cancer patients undergoing autologous donation. Finally, we have shown a small but significant improvement in collection efficiency for the Optia platform compared with the COBE Spectra platform.
authors.affiliation: SNBTS Clinical Apheresis Unit, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
authors.forename: Antony F
authors.initials: AF
authors.lastname: Cousins
authors.affiliation: SNBTS Clinical Apheresis Unit, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
authors.forename: Joy E
authors.initials: JE
authors.lastname: Sinclair
authors.affiliation: Greater Glasgow and Clyde Stem Cell Laboratory, Gartnavel General Hospital, Glasgow, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Alcorn
authors.affiliation: SNBTS Clinical Apheresis Unit, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
authors.forename: Rachel
authors.initials: R
authors.lastname: H A Green
authors.affiliation: SNBTS Clinical Apheresis Unit, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
authors.forename: Kenny W
authors.initials: KW
authors.lastname: Douglas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D019985:Benchmarking; D001781:Blood Component Removal / Q000295:instrumentation* / Q000592:standards / Q000706:statistics & numerical data; D002452:Cell Count; D002469:Cell Separation / Q000295:instrumentation* / Q000592:standards / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D012189:Retrospective Studies
chemical_list: D018952:Antigens, CD34
keywords: collection efficiency; hematopoietic stem cells; optia; peripheral CD34 count