title: Unravelling genes and pathways implicated in working memory of schizophrenia in Han Chinese.
abstract: Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify the factors underlying working memory deficit in schizophrenia patients and to explore the implication of possible genes in the working memory using genome-wide association study (GWAS) of schizophrenia, computerized delay-matching-to-sample (DMS) and whole genome genotyping data were obtained from 100 first-episode, treatment-naïve patients with schizophrenia and 140 healthy controls from the Mental Health Centre of the West China Hospital, Sichuan University. A composite score, delay-matching-to-sample total correct numbers (DMS-TC), was found to be significantly different between the patients and control. On associating quantitative DMS-TC with interactive variables of groups × genotype, one SNP (rs1411832), located downstream of YWHAZP5 in chromosome 10, was found to be associated with the working memory deficit in schizophrenia patients with lowest p-value (p = 2.02 × 10(-7)). ConsensusPathDB identified that genes with SNPs for which p values below the threshold of 5 × 10(-5) were significantly enriched in GO:0007155 (cell adhesion, p < 0.001). This study indicates that working memory, as an endophenotype of schizophrenia, could improve the efficacy of GWAS in schizophrenia. However, further study is required to replicate the results from our study.
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. sandyren_6@hotmail.com.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ren
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. zhangcc89@foxmail.com.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. chaohua118@foxmail.com.
authors.forename: Chaohua
authors.initials: C
authors.lastname: Huang
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. linaxdrs@163.com.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. xinzhishui@tom.com.
authors.forename: Mingli
authors.initials: M
authors.lastname: Li
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. li-yinfei@163.com.
authors.forename: Yinfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. mrdengwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. xiangboyulan2012@gmail.com.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Biotherapy, Psychiatric Laboratory, West China Hospital, Sichuan University, 1 Ke Yuan 4 Road, Hi-Tech Developmental Zone, Chengdu 610041, China. xiangboyulan2012@gmail.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. wangqiang130@hotmail.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China. litaohx@scu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D003710:Demography; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics; D055815:Young Adult