title: A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.
abstract: We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. duncanleung@umac.mo.
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Liu
authors.forename: Lihua
authors.initials: L
authors.lastname: Lu
authors.forename: Bingyong
authors.initials: B
authors.lastname: He
authors.forename: Daniel W J
authors.initials: DW
authors.lastname: Kwong
authors.forename: Chun-Yuen
authors.initials: CY
authors.lastname: Wong
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
mesh_terms: D051722:ADAM Proteins / Q000037:antagonists & inhibitors*; D000072198:ADAM17 Protein; D002460:Cell Line; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D011480:Protease Inhibitors; D014409:Tumor Necrosis Factor-alpha; D007495:Iridium; D048051:p38 Mitogen-Activated Protein Kinases; D051722:ADAM Proteins; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human