title: Continuous renal replacement therapy in children with multiple organ dysfunction syndrome: a case series.
abstract: There is a lack of definitive information regarding the precise indications, implementation, and outcomes of continuous renal replacement therapy (CRRT) for the treatment of critically ill children. Six children (three boys, three girls) aged from 3 days to 8 years, all of whom had multiple organ failure, were submitted to bedside CRRT using M60 filter membranes. Modified Port carbonate formula was used and clotting time was maintained between 20 and 30 minutes. Activated partial thromboplastin time was 1.5- to 2-fold normal. One patient discontinued treatment due to family decision. Marked improvements were seen in the remaining five patients, including normalization of blood urea nitrogen and creatinine levels, stabilization of electrolytes, and improvements in markers of organ function. Of note, one patient (a six-year-old male) underwent the treatment for 241 hours. All five patients were subsequently discharged and recovered uneventfully. CRRT is effective for the management of children who are critically ill due to multiple organ failure.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Yan-lin
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Hu
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Ling-hui
authors.initials: LH
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Ao
authors.initials: A
authors.lastname: Cheng
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Si-nan
authors.initials: SN
authors.lastname: Shao
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Hong
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
authors.forename: Qiu-yue
authors.initials: QY
authors.lastname: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000628:therapy*; D017582:Renal Replacement Therapy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome