title: Hiding in the dark: uncovering cancer drivers through image-guided genomics.
abstract: Genome analysis which takes into account tumor purity leads to discovery of PTEN as a tumor suppressor gene in high-grade serous ovarian cancer.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Roel Gw
authors.initials: RG
authors.lastname: Verhaak
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000473:pathology; D005260:Female; D023281:Genomics / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human