title: The possibilities and principles of methotrexate treatment of psoriasis - the updated knowledge.
abstract: Psoriasis is a chronic multifactorial disease affecting 2-4% of the general population. Due to its nature, psoriasis has a negative impact on the quality of life of patients. Therefore, the choice of an appropriate and individually tailored treatment controlling the symptoms of the disorder is necessary and continues to be a challenge for dermatologists. Therapeutic modalities in psoriasis should on the one hand be effective and on the other hand present a good safety profile. Methotrexate (MTX) is one of treatment options for psoriasis and can be administered both as monotherapy or in combination schemes. The paper presents the current state of knowledge about the possible treatment of psoriatic patients with MTX according to contemporary guidelines.
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of the Department: Prof. Zygmunt Adamski MD, PhD ; Laboratory of Allergic Skin Diseases, Poznan University of Medical Sciences, Poznan, Poland. Head of the Laboratory: Prof. Magdalena Czarnecka-Operacz.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Czarnecka-Operacz
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of the Department: Prof. Zygmunt Adamski MD, PhD.
authors.forename: Anna
authors.initials: A
authors.lastname: Sadowska-Przytocka
keywords: methotrexate; psoriasis; treatment