title: Palladium-catalyzed regioselective benzylation-annulation of pyridine N-oxides with toluene derivatives via multiple C-H bond activations: benzylation versus arylation.
abstract: A palladium-catalyzed cross-dehydrogenative coupling (CDC) reaction of pyridine N-oxides with toluenes has been developed that operates under mild conditions. 2-Benzylpyridines can be obtained directly by this method via a CDC reaction between unactivated toluenes and pyridine N-oxides. In addition, azafluorene N-oxides, of value for future medicinal chemistry applications, can be obtained successfully by this procedure via four tandem C-H bond activations.
authors.affiliation: School of Chemistry, College of Science, University of Tehran , Tehran 1417614411, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Kianmehr
authors.forename: Nasser
authors.initials: N
authors.lastname: Faghih
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry
chemical_list: D001593:Benzyl Compounds; D011725:Pyridines; D014050:Toluene; D010165:Palladium; C013229:pyridine N-oxide; C074928:2-benzylpyridine