title: Rotavirus and adenovirus gastroenteritis: time series analysis.
abstract: BACKGROUND
  This study investigated the effects of changes in weather conditions (monthly average temperature, monthly minimum temperature, monthly average humidity) on rotavirus and adenovirus gastroenteritis frequency and whether there was a seasonal correlation.
  
  
  METHODS
  Between 2006 and 2012, 4702 fecal samples were taken from patients ≤ 5 years of age with acute gastroenteritis; these samples were analyzed in terms of rotavirus group A and adenovirus serotype 40-41 antigens using time-series and negative binomial regression analysis.
  
  
  RESULTS
  Rotavirus antigens were found in 797 samples (17.0%), adenovirus antigens in 113 samples (2.4%), and rotavirus and adenovirus antigens together in 16 samples (0.3%). There was a seasonal change in rotavirus gastroenteritis (P < 0.001), and a 1°C decrease in average temperature increased the ratio of rotavirus cases in those with diarrhea by 0.523%. In addition, compared with data from other years, the number of patients was lower in the first month of 2008 and in the second month of 2012, when the temperature was below -20°C (monthly minimum temperature). There was no statistically significant relationship between adenovirus infection and change in weather conditions.
  
  
  CONCLUSIONS
  Various factors such as change in weather conditions, as well as the population's sensitivity and associated changes in activity, play a role in the spread of rotavirus infection.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Mustafa Gokhan
authors.initials: MG
authors.lastname: Gozel
authors.affiliation: Department of Econometrics, Faculty of Economics and Administrative Sciences, Cumhuriyet University, Sivas, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Turkay
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Mustafa Zahir
authors.initials: MZ
authors.lastname: Bakici
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Ahmet Sami
authors.initials: AS
authors.lastname: Güven
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Nazif
authors.initials: N
authors.lastname: Elaldi
mesh_terms: D000256:Adenoviridae / Q000276:immunology*; D000258:Adenovirus Infections, Human / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D000328:Adult; D000956:Antigens, Viral / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D012621:Seasons; D014421:Turkey / Q000453:epidemiology
chemical_list: D000956:Antigens, Viral
keywords: adenovirus; children; gastroenteritis; rotavirus; weather