title: Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene.
abstract: Recently, the potential utility of the BCP motif, as a contemporary lead optimization tactic, has generated substantial interest in medicinal chemistry. To facilitate this inquisitiveness, the concomitant development of efficient synthetic protocols is crucial. The following work discloses a new, expedient and versatile approach to one such potentially useful BCP derivative.
authors.affiliation: Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology, and Research (A*STAR), 11 Biopolis Way, Helios Block, # 03-08, Singapore 138667, Singapore. vikrant_adsool@ices.a-star.edu.sg.
authors.forename: Navanita T
authors.initials: NT
authors.lastname: Thirumoorthi
authors.forename: Chew
authors.initials: C
authors.lastname: Jia Shen
authors.forename: Vikrant A
authors.initials: VA
authors.lastname: Adsool
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D001643:Bridged Bicyclo Compounds; D001554:Benzene