title: Cancer and the gut microbiota: an unexpected link.
abstract: Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor progression and how manipulations of the gut microbiota might improve the clinical activity of anticancer agents.
authors.affiliation: Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France. laurence.zitvogel@gustaveroussy.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.affiliation: Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. INSERM, U1138, F-75006 Paris, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Viaud
authors.affiliation: Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Vétizou
authors.affiliation: Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Daillère
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Merad
authors.affiliation: Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. INSERM, U1138, F-75006 Paris, France. Pôle de Biologie, Hôpital Européen Georges Pompidou F-75015, AP-HP, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D063646:Carcinogenesis / Q000473:pathology; D064806:Dysbiosis; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D064307:Microbiota; D009369:Neoplasms / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents