title: AGE/RAGE signalling regulation by miRNAs: associations with diabetic complications and therapeutic potential.
abstract: Excessive formation of advanced glycation end-products (AGEs) presents the most important mechanism of metabolic memory that underlies the pathophysiology of chronic diabetic complications. Independent of the level of hyperglycaemia, AGEs mediate intracellular glycation of the mitochondrial respiratory chain proteins leading to excessive production of reactive oxygen species (ROS) and amplification of their formation. Additionally, AGEs trigger intracellular damage via activation of the receptor for AGEs (RAGE) signalling axis that leads to elevation of cytosolic ROS, nuclear factor kappaB (NF-κB) activation, increased expression of adhesion molecules and cytokines, induction of oxidative and endoplasmic reticulum stress. Recent studies have identified novel microRNAs (miRNAs) involved in the regulation of AGE/RAGE signalling in the context of diabetic micro- and macrovascular complications. The aim of this review is to discuss the emerging role of miRNAs on AGE/RAGE pathway and the potential use of several miRNAs as novel therapeutic targets.
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Goumenos
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Adamopoulos
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 75 Mikras Asias Street, Goudi, 11527 Athens, Greece. Electronic address: papavas@med.uoa.gr.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D035683:MicroRNAs; D016328:NF-kappa B; D017382:Reactive Oxygen Species
keywords: AGE/RAGE signalling; Diabetes; MiRNAs; Therapy