title: Magnetically optimized SERS assay for rapid detection of trace drug-related biomarkers in saliva and fingerprints.
abstract: New developments in the fields of human healthcare and social security call for the exploration of an easy and on-field method to detect drug-related biomarkers. In this paper, Au nanoparticles dotted magnetic nanocomposites (AMN) modified with inositol hexakisphosphate (IP6) were used as surface-enhanced Raman scattering (SERS) substrate to quickly monitor trace drug-related biomarkers in saliva and to on-site screen a trace drug biomarker in fingerprints. Due to inducing with an external magnet, such substrate presented a huge SERS activity, which has met the sensitivity requirement for assay to detect the drug biomarkers in saliva from the U.S. Substance Abuse and Mental Health Services Administration, and also the limit of detection for drug biomarker in fingerprint reached 100 nM. In addition, this AMN-based SERS assay was successfully conducted using a portable Raman spectrometer, which could be used to on-site and accurately differentiate between the smokers and drug addicts in near future.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Tianxi
authors.initials: T
authors.lastname: Yang
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Guo
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Shuyue
authors.initials: S
authors.lastname: Fu
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wen
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China. Electronic address: haifengyang@yahoo.com.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Yang
mesh_terms: D015415:Biomarkers / Q000032:analysis; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis; D003367:Cotinine / Q000032:analysis; D003878:Dermatoglyphics; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D059346:Magnets / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010833:Phytic Acid / Q000737:chemistry; D012463:Saliva / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D015415:Biomarkers; C005618:benzoylecgonine; D006046:Gold; D010833:Phytic Acid; D003042:Cocaine; D003367:Cotinine
keywords: Drug-biomarker; Fingerprint; Magnetic nanocomposites; Portable Raman; Saliva