title: [Application of multi-voxel proton magnetic resonance spectroscopy in different hippocampal regions of normal cognitive people].
abstract: OBJECTIVE
  To explore the reproducible metabolic test and gender difference and investigate the distribution rules of metabolite concentration in different hippocampal regions (head, body and tail) of normal cognitive people for elucidating the pathological metabolic changes.
  
  
  METHODS
  The hippocampal multi-voxel proton spectroscopy of 24 normal cognitive young volunteers scanned by a 3.0 T magnetic resonance (MR). Every volunteer was scanned thrice. The data was processed by MR post-processing workstation. The hippocampus was divided into three parts (head, body and tail) and the ratios of N-acetylaspartate (NAA)/creatine (Cr), myoinositol (MI)/Cr, MI/NAA and choline (Cho)/Cr were calculated separately. We compared the metabolic ratios of each region of bilateral hippocampi between male and female groups and three different tests, also analyzed the distribution rule of each metabolite along the long axis of hippocampus.
  
  
  RESULTS
  The metabolic ratio (NAA/Cr, MI/Cr, MI/NAA and Cho/Cr) of each region of bilateral hippocampi between male and female groups and among three tests showed no statistical differences. NAA/Cr gradually rose (P < 0.05) while MI/NAA and Cho/Cr gradually declining from bilateral hippocampal head to tail (P < 0.05). MI/Cr gradually declined from bilateral hippocampal head to tail, but there was statistical difference only between right hippocampal head and tail (P < 0.05).
  
  
  CONCLUSIONS
  The hippocampal multi-voxel proton spectroscopy is technically stable. There is no gender difference. And distribution differences and metabolite concentration trends exist along hippocampal head, body and tail.
authors.affiliation: Department of Radiology, Affiliated Yancheng Hospital, Southeast University Medical College, Yancheng 224001, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Email: shuibin1988@163.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Radiology, the Affiliated Drum Tower Hospital,Nanjing University Medical School, Nanjing 210008, China. Email: jumpingzb@163.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Lizheng
authors.initials: L
authors.lastname: Yao
authors.forename: Congsong
authors.initials: C
authors.lastname: Dong
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Huiting
authors.initials: H
authors.lastname: Wang
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives; D002794:Choline; D003071:Cognition; D003401:Creatine; D005260:Female; D006624:Hippocampus; D006801:Humans; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline