title: Proteogenomics: emergence and promise.
abstract: Proteogenomics, or the integration of proteomics with genomics and transcriptomics, is emerging as the next step towards a unified understanding of cellular functions. Looking globally and simultaneously at gene structure, RNA expression, protein synthesis and post-translational modifications have become technically feasible and offer a new perspective to molecular processes. Recent publications have highlighted the value of proteogenomics in oncology for defining the molecular signature of human tumors, and translation to other areas of biomedicine and life sciences is anticipated. This mini-review will discuss recent developments, challenges and perspectives in proteogenomics.
authors.affiliation: Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, Life Science Building, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Sam
authors.initials: S
authors.lastname: Faulkner
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Dun
authors.forename: Hubert
authors.initials: H
authors.lastname: Hondermarck
mesh_terms: D023281:Genomics; D006801:Humans; D055432:Metabolomics; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins; D012333:RNA, Messenger