title: Recent advances in Gd-chelate based bimodal optical/MRI contrast agents.
abstract: Research on bimodal contrast agents in general and optical/MRI contrast agents in particular has attracted increased attention from the scientific community in recent years. Whereas optical contrast agents reveal pathologies at the cellular or sub-cellular level, MRI contrast agents generally report physiological differences at the level of tissues and organs. The complementary information obtained from these two techniques allows for a more precise diagnosis. Furthermore the emergence of near-infrared luminophores accommodates the simultaneous detection of optical and MRI signals. The current multitude and diversity in molecular architectures mirrors the ever increasing interest in the field. In this review the developments between 2010 and mid-2014 are highlighted.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Peter
authors.initials: P
authors.lastname: Verwilst
authors.forename: Soyeon
authors.initials: S
authors.lastname: Park
authors.forename: Byungkwon
authors.initials: B
authors.lastname: Yoon
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry*; D003287:Contrast Media; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D005682:Gadolinium