title: Multiple sclerosis in Japan appears to be a milder disease compared to the UK.
abstract: Multiple sclerosis (MS) is relatively common in the West, but rare in Japan. In the literature, there are few comparative data regarding disease severity throughout the world. The objective of this study was to compare disability in patients from a UK and a Japanese MS cohort. We retrospectively analysed the clinical features of patients with MS from a UK and Japanese MS centre. The Multiple Sclerosis Severity Score (MSSS), which adjusts the Expanded Disability Status Scale score according to disease duration, was used as a marker of disease severity. One thousand one hundred forty-eight UK patients and 104 Japanese patient were identified representing the relative national prevalence. Demographics and disease duration did not differ between the groups. Median MSSS was significantly different between the two groups (Japan 3.34 vs. UK 5.87, p < 0.001). Primary progressive MS was more common in the UK (12.9%) than in the Japanese cohort (3%, p = 0.044). The majority of Japanese patients (83.7% vs. UK 17%) had been exposed to disease modifying treatments (DMTs). Exposure to DMTs did not show a significant effect on disability. In conclusion, this study suggests that MS in Japan may be associated with less disability than in UK. More Japanese patients were treated with DMTs. Differences in treatments do not seem to explain the disparity in disability severity. This suggests either genetic or environmental influences on disease severity.
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Level 3 West Wing, Headley Way, Oxford, OX3 9DU, UK.
authors.forename: L
authors.initials: L
authors.lastname: Piccolo
authors.forename: G
authors.initials: G
authors.lastname: Kumar
authors.forename: I
authors.initials: I
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Misu
authors.forename: Y
authors.initials: Y
authors.lastname: Kong
authors.forename: B
authors.initials: B
authors.lastname: Wakerley
authors.forename: S
authors.initials: S
authors.lastname: Ryan
authors.forename: A
authors.initials: A
authors.lastname: Cavey
authors.forename: K
authors.initials: K
authors.lastname: Fujihara
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Palace
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D012720:Severity of Illness Index; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult