title: Sequential maximum androgen blockade (MAB) in minimally symptomatic prostate cancer progressing after initial MAB: two case reports.
abstract: The management of castrate-resistant prostate cancer progressing after maximum androgen blockade (MAB) has evolved in the last decade with the development of several novel therapeutic options. However, the initial therapeutic strategy in these patients usually involves withdrawal of anti-androgen that can be associated with biochemical response in approximately 20% of patients. Notably, we have observed evidence of sustained biochemical response in two patients following second- and third-line MAB using rechallenge schedule of previously administered anti-androgen after latent interval. The possibility of response following sequential MAB using the same anti-androgen agent has not yet been reported.
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Mohan
authors.initials: M
authors.lastname: Hingorani
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Dixit
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Fahim
authors.initials: F
authors.lastname: Bashir
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Butt
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Hawkyard
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Khafagy
authors.affiliation: 1 Department of Clinical Oncology, Castle Hill Hospital, Cottingham, HU16 5JQ, UK ; 2 Department of Urology, Scarborough General Hospital, Scarborough, YO12 6QL, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Robertson
keywords: Prostate cancer; castrate resistance; maximum androgen blockade (MAB)