title: The treatment of chondral lesions of the knee with the microfracture technique and platelet-rich plasma.
abstract: OBJECTIVE
  to assess the efficacy of associating the microfracture technique with platelet-rich plasma (PRP) injections in the treatment of chondral lesions to promote acceleration and optimization of the healing process compared with the traditional microfracture approach.
  
  
  METHODS
  from September 2011 to August 2012, 20 patients (9 males and 11 females, aged 30-55 years) were treated. All presented with chondral lesions of the medial femoral condyle of the knee and a pain duration ranging from 8 to 12 months. The patients were randomized into two groups (A and B). Group A was treated with the microfracture technique and a total of three intra-articular injections of PRP. Group B was treated with microfractures alone. Clinical follow-up was performed at 3, 6 and 12 months after treatment. Clinical function was assessed on the basis of the International Knee Documentation Committee (IKDC) score. Pain was evaluated using a visual analogue scale (VAS).
  
  
  RESULTS
  the patients in group A had a mean baseline IKDC score of 31.2, which rose to 84.2 at 12 months. The IKDC scores in group B were at 30.1 at baseline and 81 at 12 months.
  
  
  CONCLUSIONS
  the results of our study suggest that functional recovery and resolution of pain are obtained more quickly in PRP-treated patients. We also observed a better functional outcome in the patients treated with the combination of PRP and microfractures, even at 12 months, although the difference was not statistically significant.
  
  
  METHODS
  level II, randomized clinical study.
authors.affiliation: Department of Orthopaedics, University of Sassari, Italy.
authors.forename: Andrea F
authors.initials: AF
authors.lastname: Manunta
authors.affiliation: Department of Orthopaedics, University of Sassari, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Manconi
keywords: cartilage regeneration; chondral lesions; microfracture; platelet-rich plasma