title: Natural compounds used as therapies targeting to amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that occurs throughout the world with no racial, ethnic or socioeconomic boundaries. Despite its high morbidity and mortality, there are limited medications available for ALS that may increase survival in patients with amyotrophic lateral sclerosis by approximately 2-3 months. Inasmuch as negative effects of riluzole on muscle atrophy and wasting, weakness, muscle spasticity, dysarthria, dysphagia, and overall patient quality of life and its different adverse effects, much attention has been paid to natural products and herbal medicines. Overall scientific reports indicate that natural products have beneficial effects on patients with ALS low side effects and multiple targets. In the present paper, we review the scientific reports on beneficial role of natural polyphenolic compounds in treatment of ALS.
authors.forename: Seyed F
authors.initials: SF
authors.lastname: Nabavi
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Antona
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sobarzo-Sánchez
authors.forename: Zeliha S
authors.initials: ZS
authors.lastname: Talas
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12,27100 Pavia, Italy. maria.daglia@unipv.it.
authors.forename: Seyed M
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D001688:Biological Products / Q000008:administration & dosage*; D006801:Humans; D018696:Neuroprotective Agents / Q000008:administration & dosage; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D001688:Biological Products; D018696:Neuroprotective Agents; D010936:Plant Extracts