title: Transarterial chemoembolization using gelatin sponges or microspheres plus lipiodol-doxorubicin versus doxorubicin-loaded beads for the treatment of hepatocellular carcinoma.
abstract: OBJECTIVE
  To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB).
  
  
  METHODS
  A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated.
  
  
  RESULTS
  No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C was significantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively.
  
  
  CONCLUSIONS
  In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C. ; Liver Cancer Collaborative Oncology Group, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Liu
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Ming-Ching
authors.initials: MC
authors.lastname: Ou
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Tsai
authors.affiliation: Liver Cancer Collaborative Oncology Group, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C. ; Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Xi-Zhang
authors.initials: XZ
authors.lastname: Lin
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Chien-Kuo
authors.initials: CK
authors.lastname: Wang
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C. ; Liver Cancer Collaborative Oncology Group, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Tsai
authors.affiliation: Department of Diagnostic Radiology, National Cheng-Kung University Hospital, Tainan 704, Taiwan, R.O.C.
authors.forename: Ming-Tsung
authors.initials: MT
authors.lastname: Chuang
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality; D016461:Chemoembolization, Therapeutic; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D004337:Drug Carriers / Q000737:chemistry*; D004998:Ethiodized Oil / Q000737:chemistry; D005260:Female; D005334:Fever / Q000209:etiology; D005500:Follow-Up Studies; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004998:Ethiodized Oil; D004317:Doxorubicin; D005780:Gelatin
keywords: Chemoembolization; Doxorubicin; Drug-eluting bead; Hepatocellular carcinoma; Microsphere