title: Serum visfatin concentration in acutely ill and weight-recovered patients with anorexia nervosa.
abstract: Visfatin is a recently described protein that is thought to regulate the process of adipocyte differentiation. Findings suggest that visfatin may be actively involved in the control of weight regulatory networks. However, to what extent and which role it plays in eating disorders is still poorly understood, as mixed results have been reported. The aim of the current study was to investigate serum visfatin concentrations on a cross sectional sample between acute anorexia nervosa patients (n=44), weight recovered patients (n=13) and healthy controls (n=46) and a longitudinal sample of acute patients (n=57) during weight recovery at three different time-points. Results did not show significant differences in visfatin between the three groups; however, acute patients showed a higher visfatin/BMI-SDS ratio than controls and recovered patients. Longitudinal results revealed an increase of visfatin levels during therapy. Our results suggest that high ratios of visfatin/BMI-SDS could be a state marker in acute anorexia nervosa, displaying a compensatory mechanism of the individual to maintain normal visfatin levels under malnourished conditions.
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Seidel
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: King
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Ritschel
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Döpmann
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Aachen, RWTH University, Neuenhofer Weg 21, 52074 Aachen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Bühren
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Aachen, RWTH University, Neuenhofer Weg 21, 52074 Aachen, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Seitz
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Veit
authors.initials: V
authors.lastname: Roessner
authors.affiliation: Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Strasse 44, 39120 Magdeburg, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Westphal
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, University Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Egberts
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Burghardt
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Cologne, University Cologne, Robert-Koch-Strasse 10, 50931 Cologne, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wewetzer
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Freiburg, University Freiburg, Hauptstrasse 8, 79104 Freiburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Fleischhaker
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg-Essen, Wickenburgstrasse 21, 45147 Essen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Aachen, RWTH University, Neuenhofer Weg 21, 52074 Aachen, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Herpertz-Dahlmann
authors.affiliation: Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany. Electronic address: transden.lab@uniklinikum-dresden.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000150:complications; D015992:Body Mass Index; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D013851:Thinness / Q000097:blood* / Q000209:etiology; D055815:Young Adult
chemical_list: D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Adipokines; Anorexia nervosa; Leptin; Visfatin; Weight recovered anorexia nervosa