title: Auditory midbrain implant: research and development towards a second clinical trial.
abstract: The cochlear implant is considered one of the most successful neural prostheses to date, which was made possible by visionaries who continued to develop the cochlear implant through multiple technological and clinical challenges. However, patients without a functional auditory nerve or implantable cochlea cannot benefit from a cochlear implant. The focus of the paper is to review the development and translation of a new type of central auditory prosthesis for this group of patients that is known as the auditory midbrain implant (AMI) and is designed for electrical stimulation within the inferior colliculus. The rationale and results for the first AMI clinical study using a multi-site single-shank array will be presented initially. Although the AMI has achieved encouraging results in terms of safety and improvements in lip-reading capabilities and environmental awareness, it has not yet provided sufficient speech perception. Animal and human data will then be presented to show that a two-shank AMI array can potentially improve hearing performance by targeting specific neurons of the inferior colliculus. A new two-shank array, stimulation strategy, and surgical approach are planned for the AMI that are expected to improve hearing performance in the patients who will be implanted in an upcoming clinical trial funded by the National Institutes of Health. Positive outcomes from this clinical trial will motivate new efforts and developments toward improving central auditory prostheses for those who cannot sufficiently benefit from cochlear implants. This article is part of a Special Issue entitled <Lasker Award>.
authors.affiliation: Department of Biomedical Engineering, Department of Otolaryngology, and Institute for Translational Neuroscience, University of Minnesota, 312 Church Street S.E., Minneapolis, MN, 55455, USA. Electronic address: hlim@umn.edu.
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Lim
authors.affiliation: Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str.1, Hannover, 30625, Germany. Electronic address: lenarz.thomas@mh-hannover.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lenarz
mesh_terms: D000161:Acoustic Stimulation; D000162:Acoustics; D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology; D001307:Auditory Perception; D002986:Clinical Trials as Topic; D003463:Cues; D004558:Electric Stimulation; D006801:Humans; D007245:Inferior Colliculi / Q000503:physiopathology*; D008085:Lipreading; D058117:Neural Prostheses; D019986:Persons with Hearing Disabilities / Q000523:psychology / Q000534:rehabilitation*; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation*; D020127:Recovery of Function; D013018:Sound Spectrography; D013067:Speech Perception