title: A case of angiosarcoma arising from internal jugular vein.
abstract: Primary angiosarcoma is a rare disease with a poor prognosis. It most commonly arises in the head and neck region; localization in the deep soft tissue of the neck is extremely rare. We herein present a case of angiosarcoma derived from the right internal jugular vein. A 79-year-old man presented with a 1-month history of a growing right neck mass. Computed tomography, magnetic resonance imaging, positron emission tomography-computed tomography, and fine-needle aspiration cytology revealed a malignant tumor of unknown origin. Right neck dissection was performed for both diagnosis and therapy. Immunostaining of the resected tumor cells revealed positivity for CD31, CD34, factor VIII-related antigen, and D2-40, which allowed for a definitive diagnosis of angiosarcoma. Postoperative radiotherapy (66Gy) was performed on the right neck, including the surgical bed and upper mediastinum. The patient was followed up for 10 months with no recurrence. Only six cases of angiosarcoma arising in the deep soft tissue of the neck have been reported in the English-language literature. The present report is the first to describe angiosarcoma arising from the internal jugular vein.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. Electronic address: ippei5756jp@yahoo.co.jp.
authors.forename: Ippei
authors.initials: I
authors.lastname: Kishimoto
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Shinohara
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kanazawa
authors.affiliation: Institute of Biomedical Research and Innovation, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Tona
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Harada
authors.affiliation: Department of Clinical Pathology, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Usami
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000368:Aged; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007601:Jugular Veins; D008297:Male; D019043:Vascular Neoplasms / Q000473:pathology*
keywords: Angiosarcoma; Deep neck; Jugular vein; Postoperative radiotherapy; Surgery