title: Cup-like blasts in acute myeloid leukemia.
abstract: A patient with AML with normal karyotype and the cytological pattern of cup-like blasts (CLB) is reported. The typical morphology on Pappenheim stained blood smears is shown. In addition transmission electron microscopy pictures demonstrate impressively the invaginated nuclear pocket compressing the chromatin. Cup-like blasts usually do not express CD34. There is a close relationship of CLB-AML with the molecular aberrations of NPM1 and/or FLT3-ITD.
authors.affiliation: Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.|Electron Microscopic Facility, Medical Faculty, RWTH Aachen University, Aachen, Germany.
authors.forename: Edgar
authors.initials: E
authors.lastname: Jost
authors.affiliation: Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.|Electron Microscopic Facility, Medical Faculty, RWTH Aachen University, Aachen, Germany.
authors.forename: Reinhild
authors.initials: R
authors.lastname: Herwartz
authors.affiliation: Medical Faculty, Institute for Pathology, RWTH Aachen University, Aachen, Germany.|Electron Microscopic Facility, Medical Faculty, RWTH Aachen University, Aachen, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Hoß
authors.affiliation: Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.|Electron Microscopic Facility, Medical Faculty, RWTH Aachen University, Aachen, Germany.
authors.forename: Lucia
authors.initials: L
authors.lastname: Vankann
authors.affiliation: Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.|Electron Microscopic Facility, Medical Faculty, RWTH Aachen University, Aachen, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Fuchs
mesh_terms: D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000473:pathology* / Q000648:ultrastructure; D003593:Cytoplasm / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology; D008928:Mitochondria / Q000648:ultrastructure; D000090243:Nucleophosmin