title: Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis.
abstract: E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in increased susceptibility to tumor development and subsequent tumor cell invasion and metastasis. The CDH1 C-160A polymorphism could decrease its transcription efficiency and may increase susceptibility to cancer development, but its relevance to gastric cancer is generally disputed. Consequently, we performed a meta-analysis of published case-control studies, including 4218 gastric cancer cases and 5461 controls. Overall, no significant association was observed between the CDH1 C-160A polymorphism and risk of gastric cancer in all genetic models. In the stratified analysis by total sample size, a significant association was observed in the small sample size subgroup (total sample size < 300), but the results should be interpreted with caution. In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer. Large-scale and well-designed studies are needed to confirm our findings.
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Benchun
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Chenhui
authors.initials: C
authors.lastname: Bao
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Ou
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins