title: Epidermal growth factor receptor mutations in Japanese men with lung adenocarcinomas.
abstract: BACKGROUND
  Epidermal growth factor receptor (EGFR) mutations play a vital role in the prognosis of patients with lung adenocarcinoma. Such somatic mutations are more common in women who are non-smokers with adenocarcinoma and are of Asian origin. However, to our knowledge, there are few studies that have focused on men.
  
  
  METHODS
  One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively.
  
  
  RESULTS
  EGFR mutations were positive in 48.9% and negative (wild type) in 51.1%. Overall mutation was significant in women (66.0% vs. 32.2%) compared with men (p<0.001). For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure or mixed ground-glass nodule type on computed tomography and smoking status. However, in men, EGFR mutation status was only associated with lepidic dominant histologic subtype and not the other variables. Interestingly, the Brinkman index of men with mutant EGFR also did not differ from that for the wild type (680.0±619.3 vs. 813.1±552.1 p=0.1077).
  
  
  CONCLUSIONS
  The clinical characteristics of men with lung adenocarcinoma related to EGFR mutation are not always similar to that of overall patients. Especially we failed to find the relationship between EGFR mutations and smoking status in men.
authors.affiliation: Department of Surgery II, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan E-mail : mtomita@med.miyazaki-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tomita
authors.forename: Takanori
authors.initials: T
authors.lastname: Ayabe
authors.forename: Eiichi
authors.initials: E
authors.lastname: Chosa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kawagoe
authors.forename: Kunihide
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors