title: Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect.
abstract: To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near-infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (PCL) (mPEG-Cy-PCL) are synthesized. mPEG-Cy-PCL are capable of performing NIRF imaging, photothermal therapy (PTT) on cancer cells and self-assembly nanocarriers. Cy-based micelles can encapsulate doxorubicin (Doxo@Cy-micelle) and achieve NIRF image-guided drug delivery. Doxo@Cy-micelles are nanosized micelles enhancing the accumulation of Doxo in tumor sites and decreasing side effects. Doxo@Cy-micelles exhibit an excellent PTT and synergistic chemotherapy of cancer via laser-triggered release of Doxo from micelles, eventually resulting in decreased cancer recurrence rates. The results show that Cy-based micelles are excellent nanocarriers for NIRF imaging and synergistic photothermal-chemotherapy of cancer.
authors.affiliation: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, 10051, Taiwan.
authors.forename: Yuan-I
authors.initials: YI
authors.lastname: Chen
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Peng
authors.forename: Pei-Chi
authors.initials: PC
authors.lastname: Lee
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Tsai
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Lin
authors.forename: Ying-Hsia
authors.initials: YH
authors.lastname: Shih
authors.forename: Min-Feng
authors.initials: MF
authors.lastname: Wei
authors.forename: Tsai-Yueh
authors.initials: TY
authors.lastname: Luo
authors.forename: Ming-Jium
authors.initials: MJ
authors.lastname: Shieh
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000737:chemistry*; D007834:Lasers; D051379:Mice; D008819:Mice, Nude; D008823:Micelles
chemical_list: D002232:Carbocyanines; D008823:Micelles
keywords: NIR fluorescence imaging; amphiphilic copolymers; laser-triggered; micelles; photothermal-chemotherapy