title: Limited miR-17-92 overexpression drives hematologic malignancies.
abstract: The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defects caused by miR-17-92 dysregulation, its ability to drive tumorigenesis has remained undetermined until recently. Here we demonstrate that overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies. In sum, our study provides a novel and physiologically relevant model that exposes the potent ability of miR-17-92 to act as a driver of tumorigenesis.
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Danielson
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Linsey
authors.initials: L
authors.lastname: Reavie
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Marc
authors.initials: M
authors.lastname: Coussens
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Veronica
authors.initials: V
authors.lastname: Davalos
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, United States.
authors.forename: Mireia
authors.initials: M
authors.lastname: Castillo-Martin
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Guijarro
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Maryaline
authors.initials: M
authors.lastname: Coffre
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, United States.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cordon-Cardo
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Iannis
authors.initials: I
authors.lastname: Aifantis
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Sherif
authors.initials: S
authors.lastname: Ibrahim
authors.affiliation: Department of Pathology, NYU School of Medicine, United States.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, NYU School of Medicine, United States. Electronic address: Sergei.Koralov@nyumc.org.
authors.forename: Sergei B
authors.initials: SB
authors.lastname: Koralov
authors.affiliation: Department of Pathology, NYU School of Medicine, United States. Electronic address: Eva.Hernando-Monge@nyumc.org.
authors.forename: Eva
authors.initials: E
authors.lastname: Hernando
mesh_terms: D000818:Animals; D015153:Blotting, Western; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007124:Immunoenzyme Techniques; D019426:Integrases / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: C575895:MIRN17-92 microRNA, mouse; D035683:MicroRNAs; D008840:Microfilament Proteins; D009124:Muscle Proteins; D012333:RNA, Messenger; C058992:Tagln protein, mouse; C045073:Cre recombinase; D019426:Integrases
keywords: Lymphoma; Mouse model; miR-17-92