title: No association between vitamin D levels and inflammation markers in patients with acute coronary syndrome.
abstract: OBJECTIVE
  A modern concept regards acute coronary syndrome (ACS) as an auto-inflammatory disorder. The purpose of the present study is to assess the plasma levels of inflammation related to biomarkers and cytokines in ACS patients and to correlate the values with 25-hydroxy vitamin D3 (calcidiol). There are no previously published reports concerning serum concentrations of inflammatory markers in patients with hypovitaminosis D in ACS.
  
  
  METHODS
  Eighty-eight consecutive patients with ACS [n=47 ST elevation myocardial infarction (STEMI), n=41 unstable angina pectoris (USAP)] were enrolled within 12h after symptoms. The blood samples were collected on admission in order to evaluate calcidiol, serum amyloid A (SAA), interleukin (IL)-6, interleukin (IL)-10, tumor necrosis factor-alpha (TNFα) and high sensitivity C-reactive protein (hsCRP).
  
  
  RESULTS
  Calcidiol, TNFα and SAA levels were significantly lower (p=0.01, p<0.01 and p<0.01 respectively), whereas hsCRP levels were significantly higher (p<0.01) in STEMI group as compared to USAP group. In the STEMI group, there were negative correlations between SAA and hsCRP (r=-0.347; p=0.01) and SAA and IL-6 (r=-0.356; p=0.01). There was a positive correlation between IL-6 and hsCRP (r=0.529; p<0.01). In the USAP group, it was found that there were a strong negative correlation between SAA and hsCRP (r=-0.75; p<0.01) and a positive correlation between IL-6 and TNF-α (r=0.54; p<0.01).
  
  
  CONCLUSIONS
  This study demonstrates that calcidiol levels are not associated with the inflammation markers in patients with acute phase ACS.
authors.affiliation: Antalya Public Health Center of Ministry of Health, Antalya, Turkey. Electronic address: esinerendr@gmail.com.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Hamit Yasar
authors.initials: HY
authors.lastname: Ellidag
authors.affiliation: Cardiology of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Akar
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Aydın
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yılmaz
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014807:Vitamin D / Q000097:blood*
chemical_list: D015415:Biomarkers; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D014807:Vitamin D
keywords: Acute coronary syndrome; Interleukin-10; Interleukin-6; Serum amyloid A; Vitamin D