title: Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorotrast) exposure: imaging, surgical and histo- pathologic findings of a historical case.
abstract: We report the CT, surgical and histopathologic findings of a rare case of Hepatic Angiosarcoma (HAS) diagnosed in a 85-year old women 65 years afterThorotrast (Th232) exposure for angiography. At the early arterial phase of dynamic MDCT, peripheral curvilinear and central nodular puddling of contrast produced in the 8 cm tumor.Then progressive contrast filling of the tumor was observed on the delayed scans. Associated pathognomonic signs related to previous Th232 exposure were also found comprising diffuse intrahepatic reticular bands of calcifications, numerous calcified epigastric lymph nodes and a calcified shrunken spleen. Emergency laparotomy was performed because of associated hemoperitoneum. With a delay of 65 years afterThorotrast exposure, this historical case probably represents, to our knowledge, the most delayed presentation of Th232 related HAS ever published.
authors.affiliation: Department of Diagnostic Radiology, Clinique St Luc, Bouge, Belgium. bcoulier@skynet.com
authors.forename: B
authors.initials: B
authors.lastname: Coulier
authors.forename: F
authors.initials: F
authors.lastname: Pierard
authors.forename: I
authors.initials: I
authors.lastname: Gielen
authors.forename: Ph
authors.initials: P
authors.lastname: Maldague
mesh_terms: D000369:Aged, 80 and over; D002273:Carcinogens; D003287:Contrast Media / Q000009:adverse effects*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D061330:Multidetector Computed Tomography / Q000379:methods; D013911:Thorium Dioxide / Q000009:adverse effects* / Q000032:analysis
chemical_list: D002273:Carcinogens; D003287:Contrast Media; D013911:Thorium Dioxide