title: Emerging therapies targeting intra-organ inflammation in transplantation.
abstract: Over the past several years, the field of transplantation has witnessed significant progress on several fronts; in particular, achievements have been made in devising novel immunosuppressive strategies. An under-explored area that may hold great potential to improve transplantation outcomes is the design of novel strategies to apply specifically to organs to reduce intra-graft inflammation. A growing body of evidence indicates a key role of intra-graft inflammatory cascade in potently instigating the alloimmune response. Indeed, controlling the activation of innate immunity/inflammatory responses has been shown to be a promising strategy to increase the graft acceptance and survival. In this minireview, we provide an overview of emerging targeted strategies, which can be directly applied to grafts to down-regulate intra-graft inflammation prior to transplantation.
authors.affiliation: Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Z
authors.initials: Z
authors.lastname: Solhjou
authors.forename: H
authors.initials: H
authors.lastname: Athar
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Abdi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000502:physiology; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control*; D016377:Organ Transplantation / Q000009:adverse effects*; D034741:RNA, Small Interfering / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D034741:RNA, Small Interfering
keywords: basic (laboratory) research/science; innate immunity; ischemia reperfusion injury (IRI); organ transplantation in general; rejection; tolerance