title: Targeting HER2 in the treatment of non-small cell lung cancer.
abstract: Oncogenic driver mutations have emerged as major treatment targets for molecular therapies in a variety of cancers. HER2 positivity has been well-studied in breast cancer, but its importance is still being explored in non-small cell lung cancer (NSCLC). Laboratory methods for assessment of HER2 positivity in NSCLC include immunohistochemistry (IHC) for protein overexpression, fluorescent in situ hybridization (FISH) for gene amplification, and next generation sequencing (NGS) for gene mutations. The prognostic and predictive significance of these tests remain to be validated, with an emerging association between HER2 gene mutations and response to HER2 targeted therapies. Despite the assay used to determine the HER2 status of lung tumors, all patients with advanced HER2 positive lung adenocarcinoma should be evaluated for treatment with targeted agents. Several clinical approaches for inclusion of these drugs into patient treatment plans exist, but there is no defined algorithm specific to NSCLC.
authors.affiliation: University of Connecticut Health Center, Department of Hematology/Oncology, United States. Electronic address: nmar@uchc.edu.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Mar
authors.affiliation: Saint Francis Hospital, Department of Hematology/Oncology CT, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Vredenburgh
authors.affiliation: University of Connecticut Health Center, Department of Hematology/Oncology, United States.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Wasser
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D005784:Gene Amplification; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000401:mortality; D058990:Molecular Targeted Therapy; D009154:Mutation; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D018719:Erb-b2 Receptor Tyrosine Kinases
keywords: Driver mutation; HER2 gene amplification; HER2 gene mutation; HER2 protein overexpression; HER2 targeted therapy; Lung adenocarcinoma