title: Factors affecting ¹⁸F FDOPA standardized uptake value in patients with primary brain tumors after treatment.
abstract: OBJECTIVE
  To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment.
  
  
  METHODS
  97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively.
  
  
  RESULTS
  (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade.
  
  
  CONCLUSIONS
  The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy. Electronic address: agostino.chiaravalloti@gmail.com.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fiorentini
authors.affiliation: Neuro-Oncology Unit, "Regina Elena" National Cancer Institute of Rome, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Villani
authors.affiliation: Division of Neurosurgery "Regina Elena" National Cancer Institute of Rome, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Carapella
authors.affiliation: Neuro-Oncology Unit, "Regina Elena" National Cancer Institute of Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pace
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Pietro
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Di Russo
authors.affiliation: Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Palumbo
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Floris
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata of Rome, Italy; IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport / Q000187:drug effects / Q000528:radiation effects; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine
keywords: (18)F FDOPA; Chemotherapy; Primary brain tumors; Radiotherapy; SUV; Surgery