title: Prevention of functional gastrointestinal disorders in neonates: clinical and socioeconomic impact.
abstract: Infantile colic, gastro-oesophageal reflux and constipation are the most common functional gastrointestinal disorders (FGIDs) affecting infants during the first months of life. Despite infantile colic, functional constipation and regurgitation had a self-limited pattern, they are considered a risk factor for developing different disorders later in life. The pathophysiology of these functional diseases is still controversial but there is growing evidence that an abnormal gut microbiota colonisation may play a crucial role. An early probiotic supplementation could determine a change in colonisation and may represent a new strategy for preventing FGIDs.
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Indrio
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Mauro
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Mauro
authors.affiliation: Laboratory of Experimental Physiopathology, IRCCS, Via F. Valente 4, 70013 Castellana Grotte, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Riezzo
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Panza
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cavallo
authors.affiliation: Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Francavilla
mesh_terms: D005767:Gastrointestinal Diseases / Q000191:economics / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000191:economics / Q000517:prevention & control*; D019936:Probiotics / Q000008:administration & dosage* / Q000191:economics
keywords: FGIDs; Lactobacillus reuteri; infants; neonates; probiotics