title: Juvenile alexander disease: a case report.
abstract: Alexander disease is a rare autosomal recessive disorder that is characterized by degeneration of the white matter in the central nervous system. Alexander disease is a leukodystrophy that is usually observed in early childhood but rarely in adults. It is characterized by megalencephaly, demyelinization and multiple Rosenthal fibers. Specific magnetic resonance imaging (MRI) findings and genetic investigations are necessary to diagnose the disorder. Signs of leukodystrophy were found in the bilateral white matter on a brain MRI of our four-year-old patient. He had megalencephaly since birth. We use this case to discuss Alexander disease.
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Ozkaya
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Abdullah Baris
authors.initials: AB
authors.lastname: Akcan
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kul
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Karademir
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Suleymanoglu
keywords: Alexander disease; Leukodystrophy; Megalencephaly; Pediatric neurology