title: Relationship between carotid artery intima-media thickness and small dense low-density lipoprotein cholesterol concentrations measured by homogenous assay in Japanese subjects.
abstract: BACKGROUND
  Small dense low-density lipoprotein cholesterol (sdLDL-C) concentrations correlate more strongly with coronary heart disease than other LDL-C and large LDL particle concentrations. We investigated the association between carotid artery intima-media thickness (IMT) and sdLDL-C concentrations in Japanese subjects.
  
  
  METHODS
  Carotid artery IMT, blood pressure (BP), fasting plasma sdLDL-C, glucose metabolism, lipid, and C-reactive protein concentrations were measured in 97 native Japanese subjects. Carotid artery IMT was assessed by ultrasonography, and sdLDL-C concentrations were measured by a homogenous assay. Pearson's correlation coefficient analyses and multiple regression analyses were used to examine the relationships between carotid artery IMT values, sdLDL-C values, and other clinical variables.
  
  
  RESULTS
  After multiple regression analysis, including age, sex, body mass index, systolic BP, diastolic BP, fasting plasma glucose, HbA1c, estimated glomerular filtration rate (eGFR), total-C, high-density lipoprotein (HDL)-C, triglyceride, LDL-C, non-HDL-C, large buoyant LDL-C, and sdLDL-C, carotid artery IMT remained significantly associated with age, systolic BP, diastolic BP, and sdLDL-C, whereas sdLDL-C remained significantly associated with age, total-C, HDL-C, triglycerides, and carotid artery IMT.
  
  
  CONCLUSIONS
  When measured by a homogenous assay, carotid artery IMT may have a closer relationship with sdLDL-C concentrations than other lipid parameters in Japanese subjects. sdLDL-C may be a potentially useful risk marker when assessing carotid artery IMT in Japanese subjects.
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yagi
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumino
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tsunekawa
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Araki
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nara
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ogiwara
authors.affiliation: Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan. Electronic address: mmurakam@gunma-u.ac.jp.
authors.forename: Masami
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001774:Blood Chemical Analysis; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D008078:Cholesterol, LDL / Q000097:blood* / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010316:Particle Size; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL
keywords: Carotid atherosclerosis; Japanese subjects; Small dense low-density lipoprotein (sdLDL) cholesterol