title: Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery.
abstract: A novel type of dual pH-responsive supramolecular prodrug micelles based on host-guest interactions of water-soluble pillar[5]arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Du
authors.forename: Youxiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D047250:Calixarenes; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D042541:Intracellular Space / Q000378:metabolism*; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011355:Prodrugs; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; D011092:Polyethylene Glycols; D004317:Doxorubicin