title: Population structure and antimicrobial susceptibility of Pseudomonas aeruginosa from animal infections in France.
abstract: BACKGROUND
  Pseudomonas aeruginosa is a major human pathogen, which also affects animals. It is thought that P. aeruginosa has a non-clonal epidemic population structure, with distinct isolates found in humans, animals or the environment. However, very little is known about the structure of the P. aeruginosa population from diseased animals. Data on antimicrobial resistance are also scarce.
  
  
  RESULTS
  Thirty-four already registered and 19 new MLST profiles were identified. Interestingly, a few clones were more prevalent, and clones associated to human outbreaks were also detected. Multidrug resistance phenotypes were overall rare.
  
  
  CONCLUSIONS
  We highlight the non clonal structure of the population and show a higher prevalence of specific clones, possibly correlating with higher pathogenicity. The low proportion of antimicrobial resistance contrasts with the high resistance rate of human isolates.
authors.affiliation: Agence Nationale de Sécurité Sanitaire (Anses), Unité Antibiorésistance et Virulence Bactériennes, Lyon, France. marisa.haenni@anses.fr.
authors.forename: Marisa
authors.initials: M
authors.lastname: Haenni
authors.affiliation: Laboratoire d'Hygiène Hospitalière, UMR 6249 CNRS Chrono-environnement, Université de Franche-Comté, Centre Hospitalier Universitaire, Besançon, France. dhocquet@chu-besancon.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Hocquet
authors.affiliation: Agence Nationale de Sécurité Sanitaire (Anses), Unité Antibiorésistance et Virulence Bactériennes, Lyon, France. cecile.ponsin@anses.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Ponsin
authors.affiliation: Laboratoire d'Hygiène Hospitalière, UMR 6249 CNRS Chrono-environnement, Université de Franche-Comté, Centre Hospitalier Universitaire, Besançon, France. pcholley@chu-besancon.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Cholley
authors.affiliation: Département DISC, Institut FEMTO-ST, UMR 6174 CNRS, Université de Franche-Comté, Belfort Cedex, France. christophe.guyeux@univ.fcomte.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Guyeux
authors.affiliation: Agence Nationale de Sécurité Sanitaire (Anses), Unité Antibiorésistance et Virulence Bactériennes, Lyon, France. jean-yves.madec@anses.fr.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Madec
authors.affiliation: Laboratoire d'Hygiène Hospitalière, UMR 6249 CNRS Chrono-environnement, Université de Franche-Comté, Centre Hospitalier Universitaire, Besançon, France. xbertrand@chu-besancon.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bertrand
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000382:microbiology; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology; D004285:Dogs; D024881:Drug Resistance, Bacterial; D005602:France / Q000453:epidemiology; D006734:Horse Diseases / Q000453:epidemiology / Q000382:microbiology; D006736:Horses; D010802:Phylogeny; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000662:veterinary*; D011550:Pseudomonas aeruginosa / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents