title: The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals.
abstract: The bone morphogenetic protein (BMP) family consists of several growth factor proteins that belong to the transforming growth factor-β (TGF-β) superfamily. BMPs bind to type I and type II serine-threonine kinase receptors, and transduce signals through the Smad signalling pathway. BMPs have been identified in mammalian ovaries, and functional studies have shown that they are involved in the regulation of oogenesis and folliculogenesis. This review summarizes the role of the BMP system during formation, growth and maturation of ovarian follicles in mammals.
authors.affiliation: Biotechnology Nucleus of Sobral - NUBIS,Federal University of Ceara,Sobral,CE,Brazil.
authors.forename: Rodrigo O D S
authors.initials: RO
authors.lastname: Rossi
authors.affiliation: Biotechnology Nucleus of Sobral - NUBIS,Federal University of Ceara,Sobral,CE,Brazil.
authors.forename: José J N
authors.initials: JJ
authors.lastname: Costa
authors.affiliation: Biotechnology Nucleus of Sobral - NUBIS,Federal University of Ceara,Sobral,CE,Brazil.
authors.forename: Anderson W B
authors.initials: AW
authors.lastname: Silva
authors.affiliation: Biotechnology Nucleus of Sobral - NUBIS,Federal University of Ceara,Sobral,CE,Brazil.
authors.forename: Márcia V A
authors.initials: MV
authors.lastname: Saraiva
authors.affiliation: Department of Pathobiology,Faculty of Veterinary Medicine,Utrecht University,PO Box 80.163,Utrecht,The Netherlands.
authors.forename: Robert
authors.initials: R
authors.lastname: Van den Hurk
authors.affiliation: Biotechnology Nucleus of Sobral - NUBIS,Federal University of Ceara,Av. Comandante Maurocélio Rocha Ponte 100,CEP 62041-040,Sobral,CE,Brazil.
authors.forename: José R V
authors.initials: JR
authors.lastname: Silva
mesh_terms: D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000235:genetics / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D005260:Female; D008322:Mammals; D009866:Oogenesis / Q000502:physiology*; D010053:Ovary / Q000254:growth & development* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D019485:Bone Morphogenetic Proteins; D052004:Bone Morphogenetic Protein Receptors
keywords: Folliculogenesis; Oogenesis; Ovary; Transforming growth factor