title: Serum Uric Acid and Pulse Wave Velocity Among Healthy Adults: Baseline Data From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
abstract: BACKGROUND
  We aimed to evaluate a possible association between serum uric acid (SUA) levels and carotid-to-femoral pulse wave velocity (cf-PWV) among healthy participants of the ELSA-Brasil.
  
  
  METHODS
  We excluded subjects using antihypertensive medication, diuretics, allopurinol, binge drinkers, body mass index (BMI) >35 kg/m2, and those with history of cardiovascular diseases (CVD). In a cross-sectional and sex-specific analysis, linear regression models were built having cf-PWV as dependent variable and SUA as independent variable. Multiple adjustments were subsequently made for age, heart rate and blood pressure, BMI, and fasting glucose levels as covariates. Product interaction terms were built to test interaction between SUA and other covariates.
  
  
  RESULTS
  We analyzed 1,875 men and 1,713 women (mean ages, 48.9±8.4 and 50.2±8.7 years, respectively). SUA was linearly associated with cf-PWV in men (P = 0.01) and in women (P = 0.01). After full adjustment, the association remained significant for men (P = 0.01) and no longer significant for women (P = 0.10). Fully adjusted linear coefficients β (95% CI) were 0.06 (0.015; 0.112) and 0.04 (-0.01; 0.12) in men and women, respectively. Significant interaction between SUA and age (P = 0.02) fasting glucose (P < 0.01) and BMI (P = 0.02) was found only for women.
  
  
  CONCLUSIONS
  In an apparently healthy population, SUA was significantly associated to cf-PWV in men but not in women.
authors.affiliation: Pontifícia Universidade Católica do Paraná, Curitiba, Brazil; Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; cbaena01@gmail.com.
authors.forename: Cristina Pellegrino
authors.initials: CP
authors.lastname: Baena
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil;
authors.forename: Paulo Andrade
authors.initials: PA
authors.lastname: Lotufo
authors.affiliation: Universidade Federal do Espírito Santo, Espírito Santo, Brazil.
authors.forename: José Geraldo
authors.initials: JG
authors.lastname: Mill
authors.affiliation: Universidade Federal do Espírito Santo, Espírito Santo, Brazil.
authors.forename: Roberto de Sa
authors.initials: Rde S
authors.lastname: Cunha
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil;
authors.forename: Isabela J
authors.initials: IJ
authors.lastname: Benseñor
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil; D002339:Carotid Arteries; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005263:Femoral Artery; D064368:Healthy Volunteers; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014527:Uric Acid
keywords: aortic stiffness; blood pressure; gender; hypertension; pulse wave velocity; uric acid.