title: Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder.
abstract: OBJECTIVE
  Oxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD.
  
  
  METHODS
  The study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI).
  
  
  RESULTS
  There were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all, p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all, p>0.05).
  
  
  CONCLUSIONS
  Our results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.
authors.affiliation: 1Medicine Faculty,Department of Psychiatry,Yuzuncu Yil University,Van,Turkey.
authors.forename: Pinar Guzel
authors.initials: PG
authors.lastname: Ozdemir
authors.affiliation: 2Department of Biochemistry,Dicle University,Diyarbakir,Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Kaplan
authors.affiliation: 3Department of Forensic Medicine,Dicle University,Diyarbakir,Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Uysal
authors.affiliation: 4Medicine Faculty,Department of Psychiatry,Dicle University,Diyarbakir,Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulut
authors.affiliation: 4Medicine Faculty,Department of Psychiatry,Dicle University,Diyarbakir,Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Atli
authors.affiliation: 5Medicine Faculty,Department of Psychiatry,Marmara University,İstanbul,Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Bez
authors.affiliation: 4Medicine Faculty,Department of Psychiatry,Dicle University,Diyarbakir,Turkey.
authors.forename: Mehmet Cemal
authors.initials: MC
authors.lastname: Kaya
authors.affiliation: 6Medicine Faculty,Department of Psychiatry,Yuzuncu Yil University,Van,Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D004190:Disasters; D055866:Earthquakes; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D013053:Spectrophotometry / Q000379:methods; D013313:Stress Disorders, Post-Traumatic / Q000097:blood* / Q000209:etiology / Q000523:psychology*; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology; D014421:Turkey
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: earthquake survivors; oxidative stress index; post-traumatic stress disorder; total antioxidant status; total oxidant status