title: Association of N-acetylcysteine and glucagon during percutaneous cholangiography in the treatment of inspissated bile syndrome.
abstract: Inspissated bile syndrome (IBS) is a rare neonatal disease. In the majority of cases, it resolves spontaneously and treatment is conservative. Follow-up is recommended with close monitoring of laboratory tests. When IBS does not resolve spontaneously, a catheter can be inserted into the gallbladder for cholangiography, which allows irrigation and drainage. Despite this treatment, some biliary tract obstruction may persist. We report on the case of a 3-month-old infant whose continuous biliary obstruction caused by IBS was successfully managed by interventional radiology with the association of N-acetylcysteine and glucagon. Even as first-line agents, these would allow more rapid clearance of gallstones and prevent infectious complications of indwelling catheters as well as decrease the need for surgery.
authors.affiliation: Department of pediatrics, Rouen University Hospital, 76031 Rouen cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Berrani
authors.affiliation: Department of pediatrics, Rouen University Hospital, 76031 Rouen cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Vasies
authors.affiliation: Department of pediatrics, Rouen University Hospital, 76031 Rouen cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Cron
authors.affiliation: Pediatric surgery, Rouen University Hospital, 76031 Rouen cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Bachy
authors.affiliation: Pediatric radiology, Rouen University Hospital, 76031 Rouen cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Le Dosseur
authors.affiliation: Department of pediatrics, Rouen University Hospital, 76031 Rouen cedex, France. Electronic address: Olivier.Mouterde@chu-rouen.fr.
authors.forename: O
authors.initials: O
authors.lastname: Mouterde
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D001646:Bile; D002675:Child, Preschool; D002758:Cholangiography / Q000379:methods; D001651:Cholestasis, Extrahepatic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006801:Humans; D013577:Syndrome
chemical_list: D005934:Glucagon; D000111:Acetylcysteine