title: Grading acute graft-versus-host disease: time to reconsider.
abstract: Acute graft-versus-host disease (GVHD) is a common and serious complication of allogeneic blood and marrow transplantation. Acute GVHD is commonly graded according to modified Glucksberg criteria. There is considerable within-grade heterogeneity with different patterns of skin, liver, or gut involvement. In this commentary, we provide an analytical review of ambiguities in acute GVHD severity scoring and offer specific proposals meant to generate discussion in the BMT community for adoption, refinement, and where appropriate, validation studies.
authors.affiliation: Division of Blood and Marrow Transplantation and Cellular Therapies at Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA; University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Goyal
authors.forename: Manu
authors.initials: M
authors.lastname: Goyal
authors.forename: Kumar
authors.initials: K
authors.lastname: Sankaranarayan
mesh_terms: D001803:Blood Transfusion / Q000592:standards; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000592:standards; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D017410:Practice Guidelines as Topic; D012107:Research Design; D012720:Severity of Illness Index; D065227:Transfusion Reaction; D014184:Transplantation, Homologous