title: The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy.
abstract: This commentary provides the authors' perspective on the article "Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice", published in PLoS ONE. It also discusses the caveats of using subcutaneous tumors to model the treatment of human cancers versus orthotopic mouse models that more closely mimic human disease.
authors.affiliation: Division of Cancer Research; Peter MacCallum Cancer Center ; East Melbourne, Australia.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Westwood
authors.affiliation: Division of Cancer Research; Peter MacCallum Cancer Center ; East Melbourne, Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Prahran, Australia.
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
authors.affiliation: Division of Cancer Research; Peter MacCallum Cancer Center ; East Melbourne, Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Prahran, Australia.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kershaw
keywords: cancer; immunotherapy; mouse model; orthotopic; preclinical