title: The CD4 C868T Polymorphism and Its Correlation with HIV-1 Infection in a Chinese Population.
abstract: Previous studies performed in Kenya have suggested that the C868T single nucleotide polymorphism (SNP) in CD4 increases the risk of HIV-1 acquisition; however, no relevant study has been conducted in China. To evaluate the influence of this SNP on risk of HIV-1 infection in a Chinese population, the CD4 genotype was determined by DNA sequencing in 101 HIV-1 patients and 102 healthy controls. No significant differences in the genotype and allele distributions of this polymorphism were observed among the patient and control groups. Additionally, binary logistic regression analyses adjusted by age and gender revealed that the C868T polymorphism was not associated with risk of HIV-1 infection. Furthermore, when analyses of genotype and allele frequencies were stratified by gender, similar nonsignificant results were found. Our study demonstrates a null association between the CD4 C868T polymorphism and an individual's susceptibility of HIV-1 acquisition in a Chinese population. Further studies are warranted to confirm these results.
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: Junrong
authors.initials: J
authors.lastname: Wu
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.forename: Liping
authors.initials: L
authors.lastname: Ma
authors.forename: Xiuli
authors.initials: X
authors.lastname: Huang
authors.forename: Jiangyang
authors.initials: J
authors.lastname: Zhao
authors.forename: Yanqiong
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuejie
authors.initials: X
authors.lastname: Chen
authors.forename: Shan
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People; D015704:CD4 Antigens / Q000235:genetics*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002681:China; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D018570:Risk Assessment; D017422:Sequence Analysis, DNA
chemical_list: D015704:CD4 Antigens