title: Real-time symptomatic case of transfusion-transmitted dengue.
abstract: BACKGROUND
  Dengue virus transmission by blood transfusion is a rarely reported event.
  
  
  METHODS
  During a dengue outbreak in São Paulo city, a regular plateletpheresis donor informed the blood bank of being diagnosed a few days after donation. The recipient was hospitalized and displayed symptoms and laboratory evidence of dengue after transfusion.
  
  
  RESULTS
  The donor was immunoglobulin (Ig)G, IgM, and polymerase chain reaction nonreactive on the index sample, seroconverting 20 days later. The platelet units were transfused into two patients. One of them developed fever 3 days after transfusion, with high viral load. His pretransfusion sample was negative for IgG, IgM, and dengue RNA, while the second recipient did not show any symptoms nor laboratory evidence of dengue infection.
  
  
  CONCLUSIONS
  This case brings additional evidence that dengue is indeed transmissible by blood transfusion and clinical manifestations, although rare, do occur.
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.|Virology Lab, Instituto de Medicina Tropical da Universidade de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Levi
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Anna
authors.initials: A
authors.lastname: Nishiya
authors.affiliation: Virology Lab, Instituto de Medicina Tropical da Universidade de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Alvina Clara
authors.initials: AC
authors.lastname: Félix
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Nanci Alves
authors.initials: NA
authors.lastname: Salles
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Luciana Ribeiro
authors.initials: LR
authors.lastname: Sampaio
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Fátima
authors.initials: F
authors.lastname: Hangai
authors.affiliation: Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Ester Cerdeira
authors.initials: EC
authors.lastname: Sabino
authors.affiliation: Fundação Pró-Sangue, Hemocentro de São Paulo, University of São Paulo, São Paulo, Brazil.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mendrone
mesh_terms: D003715:Dengue / Q000209:etiology* / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction