title: Role of innate and adaptive immune mechanisms in cardiac injury and repair.
abstract: Despite the advances that have been made in developing new therapeutics, cardiovascular disease remains the leading cause of worldwide mortality. Therefore, understanding the mechanisms underlying cardiovascular tissue injury and repair is of prime importance. Following cardiac tissue injury, the immune system has an important and complex role in driving both the acute inflammatory response and the regenerative response. This Review summarizes the role of the immune system in cardiovascular disease - focusing on the idea that the immune system evolved to promote tissue homeostasis following injury and/or infection, and that the inherent cost of this evolutionary development is unwanted inflammatory damage.
authors.affiliation: Toronto Medical Discovery Tower, 101 College Street, TMDT 3903 Toronto, Ontario, M5G 1L7, Canada.
authors.forename: Slava
authors.initials: S
authors.lastname: Epelman
authors.affiliation: University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Liu
authors.affiliation: Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005355:Fibrosis; D006331:Heart Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007107:Immune System; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009205:Myocarditis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D020556:Neutrophil Infiltration / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D014945:Wound Healing / Q000276:immunology*