title: [Hypoglycemia and cardiovascular risk].
abstract: Intensive glycemic control and aggressive glycated hemoglobin targets <7.0% have failed to show an improvement in cardiovascular mortality. Repetitive and severe hypoglycemic episodes with intensive glucose-lowering therapy may be a major factor in the failure to show cardiovascular benefit in diabetic patients. In this article, the cardiovascular effects of hypoglycemia, and the trials with an intensive glucose-lowering strategy that have studied microvascular and macrovascular complications are discussed. The current non-insulin drugs, which do not induce hypoglycemia, available for the treatment of diabetes and their cardiovascular impacts are clarified.
authors.forename: Angelo
authors.initials: A
authors.lastname: Avogaro
mesh_terms: D001786:Blood Glucose / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000150:complications / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents