title: IQGAPs choreograph cellular signaling from the membrane to the nucleus.
abstract: Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1 have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been identified, implicating IQGAP1 as a critical integrator of cellular signaling pathways. Initial research established functions for IQGAP1 in cell-cell adhesion, cell migration, and cell signaling. Recent studies have revealed additional IQGAP1 binding partners, expanding the biological roles of IQGAP1. These include crosstalk between signaling cascades, regulation of nuclear function, and Wnt pathway potentiation. Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1. Summarized here are recent observations that enhance our understanding of IQGAP proteins in the integration of diverse signaling pathways.
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Smith
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Hedman
authors.affiliation: Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA. Electronic address: sacksdb@mail.nih.gov.
authors.forename: David B
authors.initials: DB
authors.lastname: Sacks
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000502:physiology*; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins / Q000502:physiology*
chemical_list: D020690:GTPase-Activating Proteins; C101203:IQ motif containing GTPase activating protein 1; C101002:IQGAP2 protein, human; C000594387:IQGAP3 protein, human; D020703:ras GTPase-Activating Proteins
keywords: IQGAP1; IQGAP2; IQGAP3; scaffold; signaling