title: α-Thalassaemia trait is associated with antibody prevalence against malaria antigens AMA-1 and MSP-1.
abstract: A longitudinal study was conducted in a low endemic area in northern Tanzania to examine the influence of the α-thalassaemia trait on malaria incidence and antibody responses to malaria apical membrane antigen-1 (AMA-1) and merozoite surface protein1-19 (MSP-119). Out of 394 children genotyped for α-thalassaemia trait, 4.1% (16 of 394) and 30.7% (121 of 394) were homozygous and heterozygous, respectively. During the 1 year follow-up, four incidents of malaria cases were detected without an evident association with α-thalassaemia. Being heterozygous or homozygous for α-thalassaemia was associated with an increased prevalence of antibodies to AMA-1 [odds ratio (OR): 1.83, 95% confidence interval (CI): 1.07-3.12, p = 0.027] and MSP-1 (OR: 2.04, 95% CI: 1.16-3.60, p = 0.013) after adjustment for age and reported bednet use. The observed association between α-thalassaemia and malaria antibody responses may reflect longer-term differences in antigen exposure or differences in antibody acquisition upon exposure in this low endemic setting.
authors.affiliation: Faculty of Pharmacy, Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Mali Kilimanjaro Christians Medical, Center: Department of Kilimanjaro Clinical Research Institute Moshi Tanzania Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Modibo
authors.initials: M
authors.lastname: Daou
authors.affiliation: Kilimanjaro Christians Medical, Center: Department of Kilimanjaro Clinical Research Institute Moshi Tanzania.
authors.forename: Elimsaada
authors.initials: E
authors.lastname: Kituma
authors.affiliation: Kilimanjaro Christians Medical, Center: Department of Kilimanjaro Clinical Research Institute Moshi Tanzania.
authors.forename: Reginald
authors.initials: R
authors.lastname: Kavishe
authors.affiliation: Kilimanjaro Christians Medical, Center: Department of Kilimanjaro Clinical Research Institute Moshi Tanzania.
authors.forename: Jaffu
authors.initials: J
authors.lastname: Chilongola
authors.affiliation: Kilimanjaro Christians Medical, Center: Department of Kilimanjaro Clinical Research Institute Moshi Tanzania.
authors.forename: Frank
authors.initials: F
authors.lastname: Mosha
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: André
authors.initials: A
authors.lastname: van der Ven
authors.affiliation: Faculty of Pharmacy, Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Mali.
authors.forename: Bourema
authors.initials: B
authors.lastname: Kouriba
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, London, UK teun.bousema@radboudumc.nl.
authors.forename: Teun
authors.initials: T
authors.lastname: Bousema
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Robert
authors.initials: R
authors.lastname: Sauerwein
authors.affiliation: Faculty of Pharmacy, Department of Epidemiology of Parasitic Diseases, Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Mali.
authors.forename: Ogobaro
authors.initials: O
authors.lastname: Doumbo
mesh_terms: D000293:Adolescent; D000913:Antibodies, Protozoan / Q000276:immunology*; D000953:Antigens, Protozoan / Q000097:blood* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008288:Malaria / Q000453:epidemiology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020066:Merozoite Surface Protein 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics*; D013636:Tanzania / Q000453:epidemiology; D017085:alpha-Thalassemia / Q000453:epidemiology / Q000235:genetics*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D008565:Membrane Proteins; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C090077:apical membrane antigen I, Plasmodium
keywords: immunity; malaria; thalassaemia