title: Ultrasound modulates skeletal muscle cytokine levels in rats with heart failure.
abstract: Heart failure is a multisystemic disorder that leads to an imbalance between pro- and anti-inflammatory cytokines. Therapeutic ultrasound (TU) has been reported to modulate the inflammatory process. The aim of this study was to evaluate the effect of TU on pro- and anti-inflammatory cytokine levels in soleus muscle and plasma of rats with heart failure. Thirty male Wistar rats (230-260 g) were submitted to ligation of the left coronary artery or sham surgery. Six weeks after surgery, TU was administered directly to the right lower limb. The results indicate that TU promotes reduction of pro-inflammatory cytokine levels (tumor necrosis factor α, interleukin-6) and increases anti-inflammatory cytokine levels (interleukin-10) in the soleus muscle of rats with heart failure. This is the first study to find that TU can modulate cytokine levels in rats with heart failure. Additionally, this is a first report that TU can modulate interleukin-10 levels in the soleus muscle.
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil; Centro Universitário Franciscano, Santa Maria, Brazil.
authors.forename: Douglas Dalcin
authors.initials: DD
authors.lastname: Rossato
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Dal Lago
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Vítor Scotta
authors.initials: VS
authors.lastname: Hentschke
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Ananda Lazzarotto
authors.initials: AL
authors.lastname: Rucatti
authors.affiliation: Departamento de Fisioterapia e Reabilitação, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Luis Ulisses
authors.initials: LU
authors.lastname: Signori
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Matheus Noronha
authors.initials: MN
authors.lastname: Silveira
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. Electronic address: Roplentz@yahoo.com.br.
authors.forename: Rodrigo Della Méa
authors.initials: RD
authors.lastname: Plentz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000378:metabolism*; D019220:High-Energy Shock Waves; D016753:Interleukin-10 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: Cytokines; Heart failure; Skeletal muscle; Therapeutic ultrasound