title: Magnetofluorescent micellar complexes of terbium(III) as potential bimodal contrast agents for magnetic resonance and optical imaging.
abstract: Terbium(III) was coordinated to four novel 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) amphiphilic bisamide ligands. The complexes were assembled into mono-disperse micellar nano-aggregates and for the first time Tb(III) has been evaluated as a single lanthanide negative bimodal contrast agent for MRI/OI. The complexes show characteristic Tb(III) emission with quantum yields reaching 7.3% and transverse relaxivity r2 per Tb(III) micelle at 500 MHz and 310 K reaches maximum values up to 60 s(-1) micelle(-1). The efficient T2 relaxation at high magnetic field strengths is sustained by the increased rotational correlation time of the nano-aggregates and high magnetic moment of the terbium ion.
authors.affiliation: KU Leuven, Department of Chemistry, Celestijnenlaan 200F, 3001 Leuven, Belgium. michael.harris@chem.kuleuven.be.
authors.forename: Michael
authors.initials: M
authors.lastname: Harris
authors.forename: Sophie
authors.initials: S
authors.lastname: Carron
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Robert N
authors.initials: RN
authors.lastname: Muller
authors.forename: Tatjana N
authors.initials: TN
authors.lastname: Parac-Vogt