title: TGF-β superfamily signaling in muscle and tendon adaptation to resistance exercise.
abstract: Numerous studies in muscle and tendon have identified a central role of the transforming growth factor-β (TGF-β) superfamily of cytokines in the regulation of extracellular matrix growth and remodeling, protein degradation, and cell proliferation and differentiation. We provide a novel framework for TGF-β and myostatin signaling in controlling the coordinated adaptation of both skeletal muscle and tendon tissue to resistance training.
authors.affiliation: Departments of 1Orthopaedic Surgery, 2Molecular and Integrative Physiology, and 3Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, MI.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Gumucio
authors.forename: Kristoffer B
authors.initials: KB
authors.lastname: Sugg
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Mendias
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D055435:Myostatin / Q000378:metabolism*; D055070:Resistance Training; D015398:Signal Transduction; D013710:Tendons / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D055435:Myostatin; D016212:Transforming Growth Factor beta