title: Hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema.
abstract: We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors arising after danazol are infrequent, and this case is highly unique due to the minor lesions found on the liver.
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Soraya
authors.initials: S
authors.lastname: Rahal
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Gilabert
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Ries
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Oziel-Taieb
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Slimane
authors.initials: S
authors.lastname: Dermeche
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, Marseille, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
keywords: Danazol; Drug-induced cancer; Healthy liver; Hepatocellular carcinoma