title: Greater adherence to a Mediterranean dietary pattern is associated with improved plasma lipid profile: the Aragon Health Workers Study cohort.
abstract: OBJECTIVE
  There is wide recognition of the importance of healthy eating in cardiovascular health promotion. The purpose of this study was to identify the main dietary patterns among a Spanish population, and to determine their relationship with plasma lipid profiles.
  
  
  METHODS
  A cross-sectional analysis was conducted of data from 1290 participants of the Aragon Workers Health Study cohort. Standardized protocols were used to collect clinical and biochemistry data. Diet was assessed through a food frequency questionnaire, quantifying habitual intake over the past 12 months. The main dietary patterns were identified by factor analysis. The association between adherence to dietary patterns and plasma lipid levels was assessed by linear and logistic regression.
  
  
  RESULTS
  Two dietary patterns were identified: a Mediterranean dietary pattern, high in vegetables, fruits, fish, white meat, nuts, and olive oil, and a Western dietary pattern, high in red meat, fast food, dairy, and cereals. Compared with the participants in the lowest quintile of adherence to the Western dietary pattern, those in the highest quintile had 4.6 mg/dL lower high-density lipoprotein cholesterol levels (P < .001), 8 mg/dL lower apolipoprotein A1 levels (P = .005) and a greater risk of having decreased high-density lipoprotein cholesterol (odds ratio = 3.19; 95% confidence interval, 1.36-7.5; P-trend = .03). Participants adhering to the Mediterranean dietary pattern had 3.3mg/dL higher high-density lipoprotein cholesterol levels (P < .001), and a ratio of triglycerides to high-density lipoprotein cholesterol that was 0.43 times lower (P = .043).
  
  
  CONCLUSIONS
  Adherence to the Mediterranean dietary pattern is associated with improved lipid profile compared with a Western dietary pattern, which was associated with a lower odds of optimal high-density lipoprotein cholesterol levels in this population.
authors.affiliation: Área de Epidemiología y Genética de Poblaciones, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Electronic address: jlpenalvo@cnic.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Peñalvo
authors.affiliation: Área de Epidemiología y Genética de Poblaciones, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Oliva
authors.affiliation: Área de Epidemiología y Genética de Poblaciones, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sotos-Prieto
authors.affiliation: Área de Epidemiología y Genética de Poblaciones, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
authors.forename: Irina
authors.initials: I
authors.lastname: Uzhova
authors.affiliation: Unidad de Prevención Cardiovascular, Instituto Aragonés de Ciencias de la Salud (I+CS), Zaragoza, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Moreno-Franco
authors.affiliation: Unidad de Prevención Cardiovascular, Instituto Aragonés de Ciencias de la Salud (I+CS), Zaragoza, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: León-Latre
authors.affiliation: Área de Epidemiología y Genética de Poblaciones, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States.
authors.forename: José María
authors.initials: JM
authors.lastname: Ordovás
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000178:diet therapy* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D038441:Diet, Mediterranean; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006293:Health Promotion; D006306:Health Surveys; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D016017:Odds Ratio; D010349:Patient Compliance; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D008055:Lipids
keywords: Análisis factorial; Diet score; Dieta mediterránea; Dietary pattern; Factor analysis; Lípidos plasmáticos; Mediterranean diet; Patrón de dieta; Plasma lipids; Puntuación de dieta