title: Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NF-κB connection.
abstract: Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-κBsignaling cascade has been discussed in the end.
authors.forename: Upinder
authors.initials: U
authors.lastname: Kaur
authors.forename: Priyanjalee
authors.initials: P
authors.lastname: Banerjee
authors.forename: Aritri
authors.initials: A
authors.lastname: Bir
authors.forename: Maitrayee
authors.initials: M
authors.lastname: Sinha
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Biochemistry, Institute of Post Graduate Medical and Educational Research, 244, AJC Bose Road, Kolkata-700020, India. profschakrabarti95@gmail.com.
authors.forename: Sasanka
authors.initials: S
authors.lastname: Chakrabarti
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003474:Curcumin / Q000494:pharmacology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D045786:Diterpenes, Kaurane / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D016207:Cytokines; D045786:Diterpenes, Kaurane; D016328:NF-kappa B; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; C011959:oridonin; D003474:Curcumin