title: Dangerous leaks: blood-brain barrier woes in the aging hippocampus.
abstract: A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.
authors.affiliation: Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address: coi2001@med.cornell.edu.
authors.forename: Costantino
authors.initials: C
authors.lastname: Iadecola
mesh_terms: D000375:Aging / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000378:metabolism*; D056547:CA1 Region, Hippocampal / Q000378:metabolism*; D056654:CA3 Region, Hippocampal / Q000378:metabolism*; D060825:Cognitive Dysfunction / Q000378:metabolism*; D018891:Dentate Gyrus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male