title: Ferritin in hypertensive and diabetic women before and after bariatric surgery.
abstract: In addition to its important role as marker of iron stores, serum ferritin is a marker of systemic inflammation, and obesity has been associated with chronic inflammation.
  
  
  OBJECTIVE
  To verify, six months after surgery, the effect of bariatric surgery on the serum ferritin of women who were hypertensive, diabetic, or comorbidity free before surgery.
  
  
  METHODS
  This retrospective study included 200 women aged 20 to 45 years, with a body mass index (BMI) equal to or greater than 35 kg/m2, submitted to Roux-en-Y gastric bypass (RYGB). Seventy of these women were hypertensive, forty had type 2 diabetes (T2D), and ninety were comorbidity free (CF). They were assessed before and six months after surgery. Anthropometric, laboratory (serum ferritin and hemoglobin), and comorbidity- related data were collected from their medical records.
  
  
  RESULTS
  Before surgery, women with comorbidities were older, the hypertensives had higher BMI, and the diabetics had higher serum ferritin levels than the CF women. The study comorbidities had resolved in 68% of the hypertensive women and 86% of the diabetic women six months after RYGB. Also at this time, the serum ferritin of hypertensive women decreased from 110.1±86.3 to 88.7±80.5 ng/dL and of diabetic women, from 164.8±133.4 to 101.2±97.7 ng/dL (p0.05).
  
  
  CONCLUSIONS
  High ferritin in premenopausal obese women was associated with the main obesity-related comorbidities, and these comorbidities determined the reduction of serum ferritin after bariatric surgery.
authors.affiliation: Programa de Pós-Graduação em Alimentos e Nutrição - Ciências Nutricionais, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas (UNESP-FcFar), Araraquara-SP. mrmolive@ibb.unesp.br.
authors.forename: Flávia Andréia
authors.initials: FA
authors.lastname: Marin
authors.affiliation: Centro de Gastroenterologia e Cirurgia da Obesidade - Clínica Bariátrica, Hospital Fornecedores de Cana, Piracicaba-SP. Faculdade de Medicina da Universidade Estadual Paulista (FMUNESP), Botucatu-SP.. mrmolive@ibb.unesp.br.
authors.forename: Irineu
authors.initials: I
authors.lastname: Rasera Junior
authors.affiliation: Faculdade de Medicina da Universidade Estadual Paulista (FMUNESP), Botucatu-SP.. mrmolive@ibb.unesp.br.
authors.forename: Celso Vieira De Souza
authors.initials: CV
authors.lastname: Leite
authors.affiliation: Programa de Pós-Graduação em Alimentos e Nutrição - Ciências Nutricionais, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas (UNESP-FcFar), Araraquara-SP Instituto de Biociências da Universidade Estadual Paulista (IB-UNESP), Botucatu-SP. Brazil.. mrmolive@ibb.unesp.br.
authors.forename: Maria Rita Marques de
authors.initials: MR
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000601:surgery*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000601:surgery*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D017697:Premenopause; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D005293:Ferritins