title: New insight into cancer aneuploidy in zebrafish.
abstract: Aneuploidy is one of the most common genetic alterations in cancer cell genomes. It greatly contributes to the heterogeneity of cancer cell genomes, and its roles in tumorigenesis are attracting more and more attentions. Zebrafish is emerging as a new genetic model for many human diseases including cancer. The zebrafish cancer model has shown an equivalent degree of aneuploidy as found in corresponding human cancers, thus it provides a great tool for us to study cancer aneuploidy and, in general, cancer biology. Here, we discuss some new advances of aneuploidy and the potential usages of this cancer model system.
authors.affiliation: Department of Comparative Pathobiology, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
authors.forename: GuangJun
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Basic Medical Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
authors.forename: Jer-Yen
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Department of Comparative Pathobiology, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Cui
mesh_terms: D000782:Aneuploidy; D000818:Animals; D005393:Fish Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016678:Genome; D006801:Humans; D009374:Neoplasms, Experimental / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015027:Zebrafish / Q000235:genetics* / Q000378:metabolism
keywords: Aneuploidy; Cancer drivers; Cancer passengers; Comparative oncogenomics; Oncogene addiction; Oncogenes; Phylooncogenomics; Synthetic lethality; Tumor suppressor genes; Zebrafish