title: Monocytes compensate Kupffer cell loss during bacterial infection.
abstract: Liver Kupffer cells (KCs) are self-maintained tissue-resident macrophages. In this issue of Immunity, Blériot et al. demonstrate that bacterial infection leads to KC necroptosis and quantitative replacement by monocyte-derived macrophages that contribute to antibacterial immunity and restoration of tissue integrity.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université, UM2, 13288 Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France; Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Strasse 10, 13125 Berlin, Germany.
authors.forename: Kaaweh
authors.initials: K
authors.lastname: Molawi
authors.affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université, UM2, 13288 Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, 13288 Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, 13288 Marseille, France; Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Strasse 10, 13125 Berlin, Germany. Electronic address: sieweke@ciml.univ-mrs.fr.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Sieweke
mesh_terms: D000818:Animals; D007728:Kupffer Cells / Q000502:physiology*; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000473:pathology*; D009000:Monocytes / Q000276:immunology*