title: Acceptable pregnancy rate of unstimulated intrauterine insemination: a retrospective analysis of 17,830 cycles.
abstract: OBJECTIVE
  To evaluate the pregnancy rate (PR) of unstimulated intrauterine insemination (IUI).
  
  
  METHODS
  This was a retrospective study in a private fertility clinic. Between 2004 and 2013, a total of 4,045 women underwent 17,830 cycles of unstimulated IUI. The etiologies of subfertility in the couples were unexplained (51 %), male factor (36 %), coital problems (9.5 %), and cervical factor (3.5 %).
  
  
  RESULTS
  The PRs/cycle, between the 1st and 9th trials, in women <35, 35-37, 38-40, 41-42, and >42 years of age were 8.2, 7.3, 5.5, 3.6, and 0.9 %, respectively. In 10,076 cycles in which the male partner had a total motile sperm count ≥5 million, the PRs in the respective age groups were 9.9, 8.6, 6.1, 4.8, and 1.2 %. The largest-sized reported PRs for clomiphene citrate (CC)/IUI in the respective age groups were 11.5, 9.2, 7.3 4.3, and 1.0 % (4,199 cycles in total, Dovey et al., FertilSteril, 2008;90:2281-2286). There were no significant differences in PRs between unstimulated IUI and CC/IUI.
  
  
  CONCLUSIONS
  PR for unstimulated IUI was similar to the reported PR for CC/IUI. Although this was a retrospective study without a control group, to reduce multiple pregnancy rate, we believe that unstimulated IUI is a reasonable treatment.
authors.affiliation: Umegaoka Women's Clinic, 1-33-3, Umegaoka, Setagaya, Tokyo, 154-0022 Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Honda
authors.affiliation: Umegaoka Women's Clinic, 1-33-3, Umegaoka, Setagaya, Tokyo, 154-0022 Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Tsutsumi
authors.affiliation: Umegaoka Women's Clinic, 1-33-3, Umegaoka, Setagaya, Tokyo, 154-0022 Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Komoda
authors.affiliation: Umegaoka Women's Clinic, 1-33-3, Umegaoka, Setagaya, Tokyo, 154-0022 Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tatsumi
keywords: Controlled ovarian hyperstimulation; Intrauterine insemination; Multiple pregnancy; Pregnancy rate; Unstimulated