title: Identification and characteristics of imipenem-resistant Acinetobacter baumannii in surgical wards in a Chinese university hospital.
abstract: The aim of this study was to investigate the prevalence and characteristics of imipenem-resistant Acinetobacter baumanni isolated from surgical wards in a university hospital, China. A total of 143 non-duplicate A. baumannii were isolated from 517 inpatients in surgery intensive care units (ICUs), burn wards, and general surgery wards. Of these, 102 isolates of A. baumannii (71.3%) were resistant to imipenem. Among imipenem-resistant isolates, all isolates were resistant to almost all antimicrobial agents except polymyxin E, all isolates were positive for blaOXA-23 and blaOXA-51 in addition to ISAba1, 52 (51%) were positive for blaOXA-58, 8 (7.8%) contained blaVIM-2, which co-harbored with blaOXA-58. Molecular typing revealed the presence of three clones among imipenem-resistant isolates. This study confirmed that A. baumannii strains harboring OXA or VIM type β-lactamases are widely distributed throughout the surgery wards. The data demonstrate that there was a high prevalence of imipenem-resistant A. baumannii infection in the region.
authors.affiliation: Department of Surgery, Associated Hospital.
authors.forename: Dalin
authors.initials: D
authors.lastname: Wang
authors.forename: Linlin
authors.initials: L
authors.lastname: Ma
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Wu
authors.forename: Mingcheng
authors.initials: M
authors.lastname: Li
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D001426:Bacterial Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D003091:Colistin / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D018432:Drug Resistance, Multiple; D024901:Drug Resistance, Multiple, Bacterial; D006757:Hospital Units; D006785:Hospitals, University; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D015378:Imipenem; D001618:beta-Lactamases; C000599728:beta-lactamase OXA-23, Acinetobacter baumannii; D003091:Colistin
keywords: Acinetobacter baumannii; Imipenem-resistant; nosocomial infection