title: Anogenital giant seborrheic keratosis.
abstract: Seborrheic keratosis (SK) are very common benign epidermal tumors. Giant seborrheic keratosis (GSK) is a rare variant with clinical characteristics, which leads very often to misdiagnosis. A genital site of SK is very unusual clinical manifestation and although the cause is still unknown, current literature data point to a possible pathogenetic role of chronic friction and HPV infection. The rare genital localization makes Buschke-Löwenstein tumor and verrucous carcinoma important differential diagnoses. GSK may also show some clinical features of a melanoacanthoma, which makes cutaneous melanoma as another possible differential diagnosis. The clinical diagnosis of genital GSK is often a very difficult one, because the typical clinical features of GSK disappear and the most common dermoscopic features of GSK are usually not seen in the genital region lesions. The diagnosis of GSK of the anogenital area should be made only and always after the exact histological verification and variety of differential diagnosis should be carefully considered. The treatment of GSK is primary surgically. We present a rare case of GSK with concomitant HPV infection in the anogenital region of 72-year-old patient. Surgical approach was performed with excellent outcome.
authors.affiliation: Department of Dermatology and Allergology, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany - wollina-uw@khdf.de.
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
authors.affiliation: Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria.
authors.forename: Anastasiya
authors.initials: A
authors.lastname: Chokoeva
authors.affiliation: Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), Sofia, Bulgaria.|'Onkoderma' - Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: Center of Physical and Rehabilitative Medicine, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Heinig
authors.affiliation: Georg Schmorl Institute of Pathology, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Schönlebe
mesh_terms: D000368:Aged; D001004:Anus Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D046169:Dermoscopy; D003937:Diagnosis, Differential; D005832:Genital Diseases, Male / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D017492:Keratosis, Seborrheic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis