title: FeCl3-catalyzed self-cleaving deprotection of methoxyphenylmethyl-protected alcohols.
abstract: 4-Methoxyphenylmethyl ethers are widely utilized as alcohol protecting groups. FeCl3 effectively catalyzes the deprotection of methoxyphenylmethyl-type ethers in a self-cleaving manner to produce oligomeric derivatives and alcohols. Remarkably, the highly pure mother alcohols can be obtained without silica gel column chromatography by using the 2,4-dimethoxyphenylmethyl group as a protective group.
authors.affiliation: Laboratory of Organic Chemistry, Gifu Pharmaceutical University , 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Sawama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Masuda
authors.forename: Shota
authors.initials: S
authors.lastname: Asai
authors.forename: Ryota
authors.initials: R
authors.lastname: Goto
authors.forename: Saori
authors.initials: S
authors.lastname: Nagata
authors.forename: Shumma
authors.initials: S
authors.lastname: Nishimura
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D004987:Ethers / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D002712:Chlorides; D004987:Ethers; D005290:Ferric Compounds; D007202:Indicators and Reagents; C024555:ferric chloride