title: Direct oxidative arylation of aryl C - H bonds with aryl boronic acids via pd catalysis directed by the N,N-dimethylaminomethyl group.
abstract: Biaryl skeletons were directly constructed via palladium-catalyzed ortho-arylation of N,N-dimethyl benzylamine with aryl boronic acids with high efficiency and high regioselectivity under open-flask conditions. The N,N-dimethylaminomethyl group was first applied as a directing group in such an oxidative coupling. Various substrates proved to be efficient coupling partners, furnishing the corresponding ortho-monoarylated or -diarylated arenes in moderate to good yields under mild conditions.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS); Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China).
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Zhang
authors.forename: Jiang-Ling
authors.initials: JL
authors.lastname: Shi
authors.forename: Bi-Qin
authors.initials: BQ
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Zhao
authors.forename: Zhang-Jie
authors.initials: ZJ
authors.lastname: Shi
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006838:Hydrocarbons / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006838:Hydrocarbons; D010165:Palladium
keywords: CH activation; N,N-dimethylbenzylamine; biaryls; boronic acid; oxidative coupling