title: [Study on the relationship between prenatal monitoring index in intrahepatic cholestasis of pregnancy and perinatal prognosis].
abstract: OBJECTIVE
  To investigate the association between prenatal monitoring index in intrahepatic cholestasis of pregnancy and the perinatal prognosis, as well as the characteristics of perinatal situations.
  
  
  METHODS
  A retrospective study on the clinical data of 88 cases intrahepatic cholestasis of pregnancy and prognosis that were treated in our hospital from Jan. 2011 to Jan. 2014 was carried out. Relationship between prenatal monitoring index in intrahepatic cholestasis of pregnancy and perinatal prognosis, together with the epidemiological features of infants were analyzed.
  
  
  RESULTS
  The incidence rates of perinatal meconium stained amniotic fluid, asphyxia neonatorum, premature and fetal distress were significantly higher in the study group than those in the controls, with differences statistically significant (P < 0.05). The levels of CG,ALT,AST, TBIL, DBIL and TBA in puerperant with bad perinatal situation were significantly higher than puerperant with good perinatal situation, with the difference statistically significant(P < 0.05). Results from the multiple regression analysis indicated that close relations did exist between CG,ALT,AST, TBIL, TBA and adverse perinatal prognosis. The main perinatal risks were related to meconium stained amniotic fluid (33.3%), prematurity (28.6%), fetal distress (20.6%), asphyxia neonatorum (15.9%) and stillbirth (1.6%).
  
  
  CONCLUSIONS
  The rate of adverse perinatal prognosis was low in intrahepatic cholestasis of pregnancy, with most frequently seen as meconium stained amniotic fluid. It was necessary to monitor the level of prenatal CG, ALT, AST, TBIL and TBA in puerperant in predicting the perinatal prognosis.
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Pu'ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China. Email: lujunling@yeah.net.
authors.forename: Junling
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Pu'ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China.
authors.forename: Jingxia
authors.initials: J
authors.lastname: Kuang
authors.affiliation: Department of Gynecology and Obstetrics, Affiliated Pu'ai Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Cheng
mesh_terms: D002780:Cholestasis, Intrahepatic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D050497:Stillbirth