title: Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen.
abstract: Notch receptors are widely expressed and have recognized functions in thymocytes and mature T cells. In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Thauland
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, CA 94305, USA. Electronic address: manish.butte@stanford.edu.
authors.forename: Manish J
authors.initials: MJ
authors.lastname: Butte
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002277:Carcinoma / Q000276:immunology*; D005260:Female; D008297:Male; D020239:Receptor Cross-Talk; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch