title: Nonsteroidal anti-inflammatory drug use and endurance during running in male long-distance runners.
abstract: BACKGROUND
  The effect of ibuprofen on pain tolerance during exercise is controversial, and its effects on endurance performance have been poorly investigated.
  
  
  OBJECTIVE
  To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue (tlim) in runners with exercise-induced muscle damage.
  
  
  METHODS
  Randomized controlled clinical trial.
  
  
  METHODS
  Laboratory.
  
  
  METHODS
  Twenty healthy male long-distance runners (age = 18.8 ± 0.4 years, maximal oxygen consumption = 55.5 ± 5.9 mL·kg(-1)·min(-1)).
  
  
  METHODS
  Participants were assigned to 2 groups (ibuprofen group = 10, placebo group = 10) to perform tlim trials (speed corresponded to their previously determined secondventilatory thresholds) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol (isokinetic dynamometry). One hour before the second tlim trial, the ibuprofen group received 1.2 g ibuprofen, and the placebo group received lactose orally.
  
  
  METHODS
  Time until self-reported fatigue, heart rate, respiratory quotient, oxygen consumption, and perceived exertion were recorded during each tlim test.
  
  
  RESULTS
  Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscle-damage protocol. We observed a reduction in the endurance performance of both groups (P < .01) but no difference between groups (P = .55).
  
  
  CONCLUSIONS
  Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners.
authors.affiliation: Unilasalle, Canoas, Brazil;
authors.forename: Eduardo
authors.initials: E
authors.lastname: Da Silva
authors.forename: Ronei S
authors.initials: RS
authors.lastname: Pinto
authors.forename: Eduardo L
authors.initials: EL
authors.lastname: Cadore
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Kruel
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D015444:Exercise / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D007718:Knee Injuries / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D012420:Running / Q000502:physiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen
keywords: NSAIDs; exercise; fatigue; ibuprofen; muscle pain