title: #Nitrosocarbonyls 1: antiviral activity of N-(4-hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the influenza A virus H1N1.
abstract: Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.
authors.affiliation: Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Dalya
authors.initials: D
authors.lastname: Al-Saad
authors.affiliation: Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Misal Giuseppe
authors.initials: MG
authors.lastname: Memeo
authors.affiliation: Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Quadrelli
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000494:pharmacology; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D003511:Cyclohexanols; C000602050:N-(4-hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide; D011804:Quinolines