title: Synthesis and anticancer activity evaluation of η(5)-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands.
abstract: The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [], PP = dppm; [], PP = Xantphos), [RuCp(#)(PP)Cl] (Cp(#) = C5Me4(CH2)5OH; [], PP = dppm; [], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [] were synthesized and evaluated in vitro as anticancer agents. Compounds gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. P.C.McGowan@leeds.ac.uk.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Bárzano
authors.forename: R M
authors.initials: RM
authors.lastname: Lord
authors.forename: A M
authors.initials: AM
authors.lastname: Basri
authors.forename: R M
authors.initials: RM
authors.lastname: Phillips
authors.forename: A J
authors.initials: AJ
authors.lastname: Blacker
authors.forename: P C
authors.initials: PC
authors.lastname: McGowan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002614:Chelating Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D011756:Diphosphates / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002614:Chelating Agents; D011756:Diphosphates; D008024:Ligands; D012428:Ruthenium