title: Differentiating pre- and minimally invasive from invasive adenocarcinoma using CT-features in persistent pulmonary part-solid nodules in Caucasian patients.
abstract: OBJECTIVE
  To retrospectively investigate the diagnostic value of pre-operative CT-features between pre/minimally invasive and invasive lesions in part-solid persistent pulmonary ground glass nodules in a Caucasian population.
  
  
  METHODS
  Retrospective review of two pre-operative CTs for 31 nodules in 30 patients. There were 10 adenocarcinomas in situ, 1 minimally invasive adenocarcinoma, 20 invasive adenocarcinomas. We analyzed the correlation between histopathology and the following CT-features: maximal axial diameter, maximal orthogonal axial diameter, height, density, size of solid component, air bronchogram, pleural retraction, nodule mass, disappearance rate and their evolution during follow-up.
  
  
  RESULTS
  In univariate analysis, invasive adenocarcinomas had a higher maximal height, density, solid component size, mass, a lower disappearance rate and presented more often with pleural retraction (p<0.05). After logistic regression performed with the uncorrelated parameters using a method of selection of variables, only the size of solid component remained significant, with 100% sensitivity for invasive adenocarcinoma when larger than 5mm.
  
  
  CONCLUSIONS
  Preoperative CT-features can help differentiating in situ and minimally invasive adenocarcinomas from invasive adenocarcinomas in Caucasian patients. A solid component larger than 5mm in diameter had 100% sensitivity for the diagnosis of invasive adenocarcinoma.
authors.affiliation: Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France. Electronic address: JCohen@chu-grenoble.fr.
authors.forename: Julien G
authors.initials: JG
authors.lastname: Cohen
authors.affiliation: Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Reymond
authors.affiliation: Service de Radiologie, Université Segalen Bordeaux, Centre Hospitalier Universitaire de Bordeaux, 12 rue Dubernat, 33404 Bordeaux Cedex, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lederlin
authors.affiliation: Centre d'Investigation Clinique - Innovation Technologique (CIC-IT), Pavillon Taillefer, 38706 La Tronche Cedex, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Medici
authors.affiliation: Departement d'Anatomie et Cytologie Pathologique (DACP), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lantuejoul
authors.affiliation: Service de Radiologie, Université Segalen Bordeaux, Centre Hospitalier Universitaire de Bordeaux, 12 rue Dubernat, 33404 Bordeaux Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Departement de Pneumologie, Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France.
authors.forename: François
authors.initials: F
authors.lastname: Arbib
authors.affiliation: Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Jankowski
authors.affiliation: Centre d'Investigation Clinique - Innovation Technologique (CIC-IT), Pavillon Taillefer, 38706 La Tronche Cedex, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Moreau-Gaudry
authors.affiliation: Clinique Universitaire de Radiologie et Imagerie Médicale (CURIM), Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043 Grenoble Cedex 9, France.
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Ferretti
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000000981:diagnostic imaging; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D044465:White People / Q000706:statistics & numerical data*
keywords: Computed tomography; Lung cancer; Solitary pulmonary nodule; Thoracic surgery