title: Allylic aminations with hindered secondary amine nucleophiles catalyzed by heterobimetallic Pd-Ti complexes.
abstract: Phosphinoamide-scaffolded heterobimetallic palladium-titanium complexes are highly effective catalysts for allylic aminations of allylic chlorides with hindered secondary amine nucleophiles. Three titanium-containing ligands are shown to assemble active catalysts in situ and enable catalysis at room temperature. A variety of sterically bulky secondary amines are efficiently allylated in high yields with as little as 1 mol % palladium catalyst. Piperidine and pyrrolidine products are also efficiently generated via intramolecular aminations with hindered amine nucleophiles.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States.
authors.forename: Whitney K
authors.initials: WK
authors.lastname: Walker
authors.forename: Diana L
authors.initials: DL
authors.lastname: Anderson
authors.forename: Ryjul W
authors.initials: RW
authors.lastname: Stokes
authors.forename: Stacey J
authors.initials: SJ
authors.lastname: Smith
authors.forename: David J
authors.initials: DJ
authors.lastname: Michaelis