title: New medications in development for the treatment of hyperuricemia of gout.
abstract: OBJECTIVE
  To update recent developments in medications targeting hyperuricemia, but not including medications recently labelled in the European Union and the United States.
  
  
  RESULTS
  A new xanthine oxidase inhibitor, Topiloric (Fujiyakuhin Co., Ltd. Japan) Uriadec (Sanwa Kagaku Kenkyusho Co., Ltd. Japan), has been developed and labelled in Japan. An inhibitor of purine nucleoside phosphorylase, Ulodesine, is in development in combination with allopurinol. The rest of the medications in the pipeline for hyperuricemia are targeting renal transporters of uric acid, mainly URAT1 and OAT4, acting as uricosuric agents. Most of them, such as lesinurad and arhalofenate, are being tested in trials in combination with allopurinol and febuxostat. The most potent RDEA3170 is being tested in monotherapy, but also associated with febuxostat. Recently, medications showing dual activity, inhibiting both xanthine oxidoreductase and URAT1, have been communicated or started exploratory clinical trials. There is no report of medications targeting other transporters such as Glut9 or ABCG2.
  
  
  CONCLUSIONS
  There are a number of medications in the pipeline targeting hyperuricemia, mostly uricosurics in combination with xanthine oxidase inhibitors, but some targeting both xanthine oxidoreductase and URAT1. Increasing the number of available medications will ensure proper control of hyperuricemia to target serum urate levels in the near future for most, if not all, patients with hyperuricemia.
authors.affiliation: aDivision of Rheumatology, Hospital Santa Creu i San Pau, Barcelona bBiomedical Sciences School, Universidad Rey Juan Carlos, Madrid cDivision of Rheumatology, Hospital Universitario Cruces, and BioCruces Health Research Institute, Vizcaya, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Diaz-Torné
authors.forename: Nuria
authors.initials: N
authors.lastname: Perez-Herrero
authors.forename: Fernando
authors.initials: F
authors.lastname: Perez-Ruiz
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D015195:Drug Design; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D050113:Imino Furanoses / Q000627:therapeutic use; D058990:Molecular Targeted Therapy / Q000379:methods; D010648:Phenylacetates / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D013864:Thioglycolates / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D014528:Uricosuric Agents / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D006074:Gout Suppressants; D050113:Imino Furanoses; D010648:Phenylacetates; D011744:Pyrimidinones; D013864:Thioglycolates; D014230:Triazoles; D014528:Uricosuric Agents; C000593471:lesinurad; C000593473:arhalofenate; C000593472:ulodesine