title: Use of inhaled tobramycin in cystic fibrosis.
abstract: Chronic infection with Pseudomonas aeruginosa is associated with poor outcomes in patients with cystic fibrosis (CF). It leads to a reduced quality of life, acceleration of the decline in lung function, and increased frequency and severity of pulmonary exacerbations. Tobramycin, administered by inhalation as a long-term therapy, decreases bacterial density in airways, reduces exacerbation frequency, and improves quality of life and lung function in patients with chronic P. aeruginosa infection. In the last decade, tobramycin inhalation has become an important contributor to CF treatment as a means to control chronic infection and as a first-line treatment for the eradication of early acquisition of P. aeruginosa. Recently, a dry powder inhalation (DPI) form of tobramycin has become available, which is more convenient for administration and has comparable efficacy to the tobramycin solution. This DPI, the Podhaler™ (Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA), requires less time for treatment delivery and is more portable than a nebulizer, and so is a welcome additional therapeutic option for many patients.
authors.affiliation: Pulmonology and CF Center, Carmel Medical Center, and the Rappaport Faculty of Medicine, Haifa, Israel, michalsh@tx.technion.ac.il.
authors.forename: Michal
authors.initials: M
authors.lastname: Shteinberg
authors.forename: J Stuart
authors.initials: JS
authors.lastname: Elborn
mesh_terms: D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D058995:Dry Powder Inhalers / Q000379:methods; D006801:Humans; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D011788:Quality of Life; D012129:Respiratory Function Tests; D014031:Tobramycin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin