title: Facile Synthesis of Molecularly Imprinted Graphene Quantum Dots for the Determination of Dopamine with Affinity-Adjustable.
abstract: A facilely prepared fluorescence sensor was developed for dopamine (DA) determination based on polyindole/graphene quantum dots molecularly imprinted polymers (PIn/GQDs@MIPs). The proposed sensor exhibits a high sensitivity with a linear range of 5 × 10(-10) to 1.2 × 10(-6) M and the limit of detection as low as 1 × 10(-10) M in the determination of DA, which is probably due to the tailor-made imprinted cavities for binding DA thought hydrogen bonds between amine groups of DA and oxygen-containing groups of the novel composite. Furthermore, the prepared sensor can rebind DA in dual-type: a low affinity type (noncovalent interaction is off) and a high affinity type (noncovalent interaction is on), and the rebinding interaction can be adjusted by tuning the pH, which shows a unique potential for adjusting the binding interaction while keeping the specificity, allowing for wider applications.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Anqi
authors.initials: A
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Chenfei
authors.initials: C
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Shishan
authors.initials: S
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D015374:Biosensing Techniques; D004298:Dopamine / Q000737:chemistry / Q000302:isolation & purification*; D055664:Electrochemical Techniques; D005453:Fluorescence; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D054802:Molecular Imprinting; D011108:Polymers / Q000737:chemistry; D045663:Quantum Dots
chemical_list: D011108:Polymers; D006108:Graphite; D004298:Dopamine
keywords: affinity-adjustable; dopamine; fluorescence; graphene quantum dots; molecularly imprinted polymer; polyindole