title: Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines.
abstract: Various tetrasubstituted pyrroles/pyrazoles have been prepared from nitro-substituted 1,3-enynes with aromatic amines/hydrazines via a copper-catalyzed cascade aza-Michael addition, cyclization and aromatization at room temperature. This protocol is also effective for the synthesis of tetrasubstituted pyrazoles in high yields.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. tpunni@iitg.ernet.in.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Bharathiraja
authors.forename: Mani
authors.initials: M
authors.lastname: Sengoden
authors.forename: Masanam
authors.initials: M
authors.lastname: Kannan
authors.forename: Tharmalingam
authors.initials: T
authors.lastname: Punniyamurthy
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D009942:Organometallic Compounds; D011758:Pyrroles; D003300:Copper