title: [Serum adiponectin levels in children with Kawasaki disease].
abstract: OBJECTIVE
  To explore the change in serum adiponectin levels and its significance in children with Kawasaki disease (KD).
  
  
  METHODS
  Forty-five KD patients were enrolled in this study, including 18 with coronary artery lesions (CAL group) and 27 without coronary artery lesions (NCAL group). Twenty healthy children were recruited to the control group. Enzyme-linked immunosorbent assay was used to measure serum adiponectin levels, and an automatic biochemical analyzer was used to measure the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).
  
  
  RESULTS
  The serum adiponectin levels in the CAL and NCAL groups were significantly lower than in the control group during the acute phase, subacute phase, and recovery phase (P<0.01), with lower levels observed during the acute phase and subacute phase (P<0.01). Compared with the NCAL group, the CAL group had significantly higher serum levels of adiponectin during the acute phase and recovery phase (P<0.05). The levels of TC, HDL, and LDL in the NCAL and CAL groups were significantly lower than in the control group (P<0.05). The levels of serum adiponectin in KD patients were positively correlated with the levels of TC, TG, and C-reactive protein and the occurrence of CAL (r=0.31, 0.30, 0.34, and 0.35, respectively; P<0.05).
  
  
  CONCLUSIONS
  Children with KD have metabolic disorders of blood lipids and reduced serum adiponectin levels. Reduced serum adiponectin levels may be the result of systemic inflammation, while increased adiponectin levels may be closely associated with the occurrence of CAL.
authors.affiliation: Department of Pediatrics, Shenzhen Maternity and Child Health Care Hospital, Shenzhen, Guangdong 518028, China. szdonggq@yeah.net.
authors.forename: Miao
authors.initials: M
authors.lastname: Huang
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Dong
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Jiang
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Zhang
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Shi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*
chemical_list: D052242:Adiponectin; D008055:Lipids