title: Non-integer viscoelastic constitutive law to model soft biological tissues to in-vivo indentation.
abstract: OBJECTIVE
  During the last decades, derivatives and integrals of non-integer orders are being more commonly used for the description of constitutive behavior of various viscoelastic materials including soft biological tissues. Compared to integer order constitutive relations, non-integer order viscoelastic material models of soft biological tissues are capable of capturing a wider range of viscoelastic behavior obtained from experiments. Although integer order models may yield comparably accurate results, non-integer order material models have less number of parameters to be identified in addition to description of an intermediate material that can monotonically and continuously be adjusted in between an ideal elastic solid and an ideal viscous fluid.
  
  
  METHODS
  In this work, starting with some preliminaries on non-integer (fractional) calculus, the "spring-pot", (intermediate mechanical element between a solid and a fluid), non-integer order three element (Zener) solid model, finally a user-defined large strain non-integer order viscoelastic constitutive model was constructed to be used in finite element simulations. Using the constitutive equation developed, by utilizing inverse finite element method and in vivo indentation experiments, soft tissue material identification was performed.
  
  
  RESULTS
  The results indicate that material coefficients obtained from relaxation experiments, when optimized with creep experimental data could simulate relaxation, creep and cyclic loading and unloading experiments accurately.
  
  
  CONCLUSIONS
  Non-integer calculus viscoelastic constitutive models, having physical interpretation and modeling experimental data accurately is a good alternative to classical phenomenological viscoelastic constitutive equations.
authors.affiliation: Department of Mechanical Engineering, Middle East Technical University, Ankara, Turkey.
authors.forename: Nagehan
authors.initials: N
authors.lastname: Demirci
authors.affiliation: Department of Mechanical Engineering, Graduate Program of Biomedical Engineering, Biomaten, Center of Exellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey.
authors.forename: Ergin
authors.initials: E
authors.lastname: Tönük
mesh_terms: D003198:Computer Simulation; D055119:Elastic Modulus; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D016014:Linear Models; D008954:Models, Biological; D009928:Organ Specificity; D013314:Stress, Mechanical; D014783:Viscosity