title: Mode of iron(III) chelation by hexadentate hydroxypyridinones.
abstract: Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(III) and gallium(III) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A widely studied tripodal ligand NTA(BuHP)3, which is reported to form 1:1 iron(III) and gallium(III) complexes in aqueous, media forms 2:2 complexes under physiological conditions. This important difference has implications for both iron chelation therapy and PET imaging.
authors.affiliation: Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
authors.forename: Xiaole
authors.initials: X
authors.lastname: Kong
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D011725:Pyridines / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D005290:Ferric Compounds; D008024:Ligands; D011725:Pyridines; C506370:hexadentate 3-hydroxypyridin-4-one; D005708:Gallium