title: Severe measles pneumonia in adults with respiratory failure: role of ribavirin and high-dose vitamin A.
abstract: Although measles is usually considered a benign viral disease of childhood, adults may be affected at any age and may experience severe respiratory or neurologic consequences. We present three adult cases (one of whom was pregnant) admitted to our University Hospital who were diagnosed to have measles and who had uncommon clinical features such as hepatitis and hyponatremia. All patients were markedly hypoxic; one required mechanical ventilation. Two patients received therapy with intravenous ribavirin and all patients received high-dose vitamin A for 3 days. Therapy with intravenous ribavirin and vitamin A were well tolerated by our patients except one patient who developed acute renal failure and were associated with reversal of respiratory compromise. Life-threatening measles pneumonitis in adults may be more common than previously appreciated, regardless of the patient's immune status, and ribavirin and high-dose vitamin A might be a treatment option.
authors.affiliation: Section of Medical Intensive Care Unit, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. nebruortac@mynet.com.
authors.forename: Ebru
authors.initials: E
authors.lastname: Ortac Ersoy
authors.affiliation: Section of General Internal Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mine D
authors.initials: MD
authors.lastname: Tanriover
authors.affiliation: Section of Medical Intensive Care Unit, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Ocal
authors.affiliation: Section of General Internal Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Ozisik
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Cagkan
authors.initials: C
authors.lastname: Inkaya
authors.affiliation: Section of Medical Intensive Care Unit, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Topeli
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008457:Measles / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D011024:Pneumonia, Viral / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy / Q000821:virology; D012254:Ribavirin / Q000008:administration & dosage*; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage*
chemical_list: D014801:Vitamin A; D012254:Ribavirin
keywords: measles; pneumonia; respiratory insufficiency; ribavirin; vitamin A