title: Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum.
abstract: Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Chen
authors.forename: Hucheng
authors.initials: H
authors.lastname: Zhu
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
authors.forename: Gentao
authors.initials: G
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Tong
authors.forename: Guangmin
authors.initials: G
authors.lastname: Yao
authors.forename: Zengwei
authors.initials: Z
authors.lastname: Luo
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Xue
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D001181:Arthropods / Q000382:microbiology*; D002597:Chaetomium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins; D026121:Indole Alkaloids; C000596510:armochaeglobine A; C000596511:armochaeglobine B