title: Characterization of a mammalian prosencephalic functional plan.
abstract: Hypothalamic organizational concepts have greatly evolved as the primary hypothalamic pathways have been systematically investigated. In the present review, we describe how the hypothalamus arises from a molecularly heterogeneous region of the embryonic neural tube but is first differentiated as a primary neuronal cell cord (earliest mantle layer). This structure defines two axes that align onto two fundamental components: a longitudinal tractus postopticus(tpoc)/retinian component and a transverse supraoptic tract(sot)/olfactory component. We then discuss how these two axonal tracts guide the formation of all major tracts that connect the telencephalon with the hypothalamus/ventral midbrain, highlighting the existence of an early basic plan in the functional organization of the prosencephalic connectome.
authors.affiliation: EA 3922, SFR FED 4234, UFR Sciences Médicales et Pharmaceutiques, Université de Franche-Comté Besançon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Croizier
authors.affiliation: EA 3922, SFR FED 4234, UFR Sciences Médicales et Pharmaceutiques, Université de Franche-Comté Besançon, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Chometton
authors.affiliation: EA 3922, SFR FED 4234, UFR Sciences Médicales et Pharmaceutiques, Université de Franche-Comté Besançon, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Fellmann
authors.affiliation: EA 3922, SFR FED 4234, UFR Sciences Médicales et Pharmaceutiques, Université de Franche-Comté Besançon, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Risold
keywords: cell cord; lateral hypothalamic area; medial forebrain bundle; melanin concentrating hormone; pioneer tracts