title: Nosocomial infections in the intensive care unit: Incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of Eastern India.
abstract: BACKGROUND
  The increased morbidity and mortality associated with nosocomial infections in the intensive care unit (ICU) is a matter of serious concern today.
  
  
  OBJECTIVE
  To determine the incidence of nosocomial infections acquired in the ICU, their risk factors, the causative pathogens and the outcome in a tertiary care teaching hospital.
  
  
  METHODS
  This was a prospective observational study conducted in a 12 bedded combined medical and surgical ICU of a medical college hospital. The study group comprised 242 patients admitted for more than 48 h in the ICU. Data were collected regarding severity of the illness, primary reason for ICU admission, presence of risk factors, presence of infection, infecting agent, length of ICU and hospital stay, and survival status and logistic regression analysis was done.
  
  
  RESULTS
  The nosocomial infection rate was 11.98% (95% confidence interval 7.89-16.07%). Pneumonia was the most frequently detected infection (62.07%), followed by urinary tract infections and central venous catheter associated bloodstream infections. Prior antimicrobial therapy, urinary catheterization and length of ICU stay were found to be statistically significant risk factors associated with nosocomial infection. Nosocomial infection resulted in a statistically significant increase in length of ICU and hospital stay, but not in mortality.
  
  
  CONCLUSIONS
  Nosocomial infections increase morbidity of hospitalized patients. These findings can be utilized for planning nosocomial infection surveillance program in our setting.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Sugata
authors.initials: S
authors.lastname: Dasgupta
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India.
authors.forename: Soumi
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Medical Research, Breach Candy Hospital, Mumbai, Maharashtra, India.
authors.forename: Neeraj S
authors.initials: NS
authors.lastname: Chawan
authors.affiliation: Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Hazra
keywords: Intensive care unit; morbidity; mortality; nosocomial infection; risk factors