title: [Expression of vascular endothelial growth factor in skin lesions and sera from patients with psoriasis vulgaris].
abstract: OBJECTIVE
  To explore the relationship between vascular endothelial growth factor (VEGF) and the onset of psoriasis.
  
  
  METHODS
  The intensity and site expression of VEGF in 34 psoriatic lesions and skin samples of 21 normal controls were observed by immunohistochemistory from December 2011 to May 2013. And the serum levels of VEGF in 70 psoriasis vulgaris and 39 normal controls were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The expression of VEGF in psoriatic lesions was much higher than that in normal controls (χ(2) = 13.34, P < 0.01) . The serum level of VEGF in psoriasis vulgaris was higher than that in normal controls ( (501 ± 13) vs (413 ± 5) ng/L, t = 2.32, P < 0.01). The serum level of VEGF in psoriasis vulgaris with PASI score >10 was higher than that with PASI score ≤ 10 ( (530 ± 18) vs (451 ± 8) ng/L, t = 2.18, P < 0.01).
  
  
  CONCLUSIONS
  VEGF may play a role in the pathogenesis of psoriasis.
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Yilei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhai
authors.affiliation: Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China. Email: pfkl2011@126.com.
authors.forename: Jiuhong
authors.initials: J
authors.lastname: Li
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D011565:Psoriasis; D042461:Vascular Endothelial Growth Factor A
chemical_list: D042461:Vascular Endothelial Growth Factor A