title: Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations.
abstract: OBJECTIVE
  Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and is the most common NHL subtype diagnosed worldwide. The first large-scale genome-wide association study (GWAS) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNPs that achieved genome-wide significance, and two SNPs that showed a suggestive association with DLBCL risk.
  
  
  METHODS
  To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand.
  
  
  RESULTS
  Three of the five genome-wide significant SNPs from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS, EXOC2 rs116446171, which achieved genome-wide significance in our data (per allele OR = 2.04, 95% CI = 1.63-2.56; ptrend = 3.9 × 10(-10)). Additionally, we observed a significant association with PVT1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19-1.52; ptrend = 2.1 × 10(-6)), which was the second strongest finding in the GWAS, and with HLA-B rs2523607 (per allele OR = 3.05, 95% CI = 1.32-7.05; ptrend = 0.009).
  
  
  CONCLUSIONS
  Our study, which provides the first evaluation in Eastern Asians of SNPs definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Bassig
authors.affiliation: Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
authors.forename: Wing-Yan
authors.initials: WY
authors.lastname: Au
authors.affiliation: Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea.|Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea.
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Research Division, National Cancer Institute, Bangkok, Thailand.
authors.forename: Suleeporn
authors.initials: S
authors.lastname: Sangrajrang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
authors.forename: Jovic
authors.initials: J
authors.lastname: Tse
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Sonja
authors.initials: S
authors.lastname: Berndt
authors.affiliation: Yale University School of Public Health, New Haven, CT, USA.
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Yale University School of Public Health, New Haven, CT, USA.
authors.forename: Heping
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Medical Oncology Department, National Cancer Institute, Bangkok, Thailand.
authors.forename: Pattarapong
authors.initials: P
authors.lastname: Pornsopone
authors.affiliation: Department of Hematology/Oncology, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Je-Jung
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea.|Department of Hematology/Oncology, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Hyeoung-Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Epidemiology, The University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
authors.forename: Christine F
authors.initials: CF
authors.lastname: Skibola
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Vijai
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.|Cancer Genomics Research Laboratory, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Burdette
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.|Cancer Genomics Research Laboratory, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.affiliation: Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.affiliation: Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, South Korea.|Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
authors.forename: Raymond
authors.initials: R
authors.lastname: Liang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
mesh_terms: D000328:Adult; D000368:Aged; D005202:Asia, Eastern; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D033921:Vesicular Transport Proteins / Q000235:genetics*
chemical_list: C470182:EXOC2 protein, human; D033921:Vesicular Transport Proteins
keywords: Diffuse large B-cell lymphoma; Eastern Asians; genetic susceptibility to DLBCL; lymphoma