title: Evaluation of Candidate Genes Related  to Neuronal Apoptosis in Late-Onset  Alzheimer’s Disease.
abstract: The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780;OR= 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer’s disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer’s disease and human leukocyte antigen.
authors.affiliation: Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Moreno-Grau
authors.forename: Bruna
authors.initials: B
authors.lastname: Barneda
authors.forename: Paulina
authors.initials: P
authors.lastname: Carriba
authors.forename: Juan
authors.initials: J
authors.lastname: Marín
authors.forename: Oscar
authors.initials: O
authors.lastname: Sotolongo-Grau
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernández
authors.forename: Maitée
authors.initials: M
authors.lastname: Rosende-Roca
authors.forename: Ana
authors.initials: A
authors.lastname: Mauleón
authors.forename: Liliana
authors.initials: L
authors.lastname: Vargas
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.forename: Montserrat
authors.initials: M
authors.lastname: Alegret
authors.forename: Octavio
authors.initials: O
authors.lastname: Rodriguez
authors.forename: Gemma
authors.initials: G
authors.lastname: Ortega
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Fernández
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Arrieta
authors.forename: Lluís
authors.initials: L
authors.lastname: Tárraga
authors.forename: Mercè
authors.initials: M
authors.lastname: Boada
authors.forename: Carmen
authors.initials: C
authors.lastname: Antúnez
authors.forename: Joaquin
authors.initials: J
authors.lastname: López
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
authors.forename: Joan Xavier
authors.initials: JX
authors.lastname: Comella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D000077265:Donepezil; D053222:Fas Ligand Protein / Q000235:genetics; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D015201:Meta-Analysis as Topic; D010597:Pharmacogenetics; D010880:Piperidines / Q000627:therapeutic use; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D002800:Cholinesterase Inhibitors; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007189:Indans; D010880:Piperidines; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D000077265:Donepezil; D019389:Cytochrome P-450 CYP2D6