title: Mania after misuse of dextromethorphan: a case report and brief review of "robotripping".
abstract: Dextromethorphan (DXM) in combination with antihistamines and/or pseudoephedrine is widely available as an over-the-counter remedy commonly used for relief of colds and cough. In supratherapeutic amounts, DXM can be extremely activating. These cough preparations have been adopted by many young users of recreational drugs for their psychoactive effects. When used in amounts exceeding those recommended, this practice, known as "robotripping," may result in a manic toxidrome of psychomotor agitation, hostility, grandiose behavior, hallucinations, paranoia, and panic. A case illustration of this phenomenon is described and implications of this phenomenon discussed. There are few reports associating DXM use with bipolar symptomatology.
authors.affiliation: From the Department of Psychiatric Medicine, Brody School of Medicine, East Carolina University, Greenville, NC.
authors.forename: Cornel N
authors.initials: CN
authors.lastname: Stanciu
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Penders
mesh_terms: D000996:Antitussive Agents / Q000009:adverse effects; D001714:Bipolar Disorder / Q000139:chemically induced*; D003915:Dextromethorphan / Q000009:adverse effects*; D005260:Female; D006801:Humans; D004366:Nonprescription Drugs / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000996:Antitussive Agents; D004366:Nonprescription Drugs; D003915:Dextromethorphan