title: Phenomics research on coronary heart disease based on human phenotype ontology.
abstract: The characteristics of holistic, dynamics, complexity, and spatial and temporal features enable "Omics" and theories of TCM to interlink with each other. HPO, namely, "characterization," can be understood as a sorting and generalization of the manifestations shown by people with diseases on the basis of the phenomics. Syndrome is the overall "manifestation" of human body pathological and physiological changes expressed by four diagnostic methods' information. The four diagnostic methods' data could be the most objective and direct manifestations of human body under morbid conditions. In this aspect, it is consistent with the connation of "characterization." Meanwhile, the four diagnostic methods' data also equip us with features of characterization in HPO. In our study, we compared 107 pieces of four diagnostic methods' information with the "characterization database" to further analyze data of four diagnostic methods' characterization in accordance with the common characteristics of four diagnostic methods' information and characterization and integrated 107 pieces of four diagnostic methods' data to relevant items in HPO and finished the expansion of characterization information in HPO.
authors.affiliation: The Key Institute of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea), China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Gao
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road, Beijing 100190, China.
authors.forename: Peng
authors.identifier: 0000-0002-9288-9075
authors.initials: P
authors.lastname: Lu
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000175:diagnosis* / Q000503:physiopathology; D064229:Biological Ontologies; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010641:Phenotype; D014059:Tongue / Q000502:physiology