title: Chimeric hepatitis B virus (HBV)/hepatitis C virus (HCV) subviral envelope particles induce efficient anti-HCV antibody production in animals pre-immunized with HBV vaccine.
abstract: The development of an effective, affordable prophylactic vaccine against hepatitis C virus (HCV) remains a medical priority. The recently described chimeric HBV-HCV subviral envelope particles could potentially be used for this purpose, as they could be produced by industrial procedures adapted from those established for the hepatitis B virus (HBV) vaccine. We show here, in an animal model, that pre-existing immunity acquired through HBV vaccination does not influence the immunogenicity of the HCV E2 protein presented by these chimeric particles. Thus, these chimeric HBV-HCV subviral envelope particles could potentially be used as a booster in individuals previously vaccinated against HBV, to induce protective immunity to HCV.
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, 10 bld Tonnelle, Tours, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Beaumont
authors.affiliation: INSERM U966, Université François Rabelais and CHRU de Tours, 10 bld Tonnelle, Tours, France. Electronic address: roingeard@med.univ-tours.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Roingeard
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology*; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007114:Immunization; D011817:Rabbits; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology*; D058425:Vaccines, Virus-Like Particle / Q000276:immunology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011993:Recombinant Fusion Proteins; D058425:Vaccines, Virus-Like Particle; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus
keywords: Immune response; Liver diseases; Preventive vaccination; Subviral envelope particles; Viral hepatitis