title: [Evaluating the risk of ischemic cerebral vascular disease with ocular hemodynamics in carotid artery stenosis patients].
abstract: OBJECTIVE
  To evaluate the association between the ocular hemodynamic and the incidence of ischemic cerebral vascular diseases in carotid artery stenosis patients.
  
  
  METHODS
  Case-control study. Seventy-two cases patients with carotid artery stenosis including 22 cases of cerebral infarction group, 14 cases of lacunar cerebral infarction group and the control group of the other 36 patients without cerebral infarction were recruited. All patients were measured with hemodynamic parameters of the ophthalmic artery, central retinal artery and posterior ciliary artery. PSV, EDV, PI and RI were also measured. The other risk ischemic cerebral vascular factors were obtained through the questionnaire and venous blood sampling. The differences of 3 groups and the influences of the other risk factor of hemodynamic were calculated.
  
  
  RESULTS
  PSV of ophthalmic artery was (25.96 ± 12.63)cm/s in cerebral infarction group, (32.63 ± 13.25) cm/s in lacunar infarction group and (39.46 ± 14.97) cm/s in control group. EDV of ophthalmic artery was(6.09 ± 3.10) cm/s in cerebral infarction group, (6.57 ± 2.85) cm/s in lacunar infarction group and (9.73 ± 5.02) cm/s in control group. PSV of central retinal artery was (8.06 ± 2.98) cm/s in cerebral infarction group, (8.91 ± 2.76) cm/s in lacunar infarction group and (9.71 ± 2.60) cm/s in control group. The differences were statistically significant (F = 13.393, 12.609, 5.027, P < 0.01). EDV of central retinal artery was (2.46 ± 0.77) cm/s in cerebral infarction group, (2.35 ± 0.89) cm/s in lacunar infarction group and (2.73 ± 0.86) cm/s in control group. There was no statistical difference of EDV of CRA in three group (F = 2.405, P = 0.094).
  
  
  CONCLUSIONS
  There was association between the ocular hemodynamic parameters and the incidence of ischemic cerebrovascular disease in the carotid artery stenosis patients. Increased level of PSV and EDV of the ophthalmic artery raised the risk of the incidence of ischemic cerebrovascular disease.
authors.affiliation: Department of Ophthalmology,Beijing Friendship Hospital, Capital Medical University,Beijing 100050, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Email: luluzhaozl@sina.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.forename: Guoli
authors.initials: G
authors.lastname: Xie
authors.forename: Jialin
authors.initials: J
authors.lastname: Wang
authors.forename: Yanling
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Feng
mesh_terms: D001783:Blood Flow Velocity; D020520:Brain Infarction / Q000209:etiology*; D016893:Carotid Stenosis / Q000150:complications* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D009880:Ophthalmic Artery / Q000503:physiopathology; D012161:Retinal Artery / Q000503:physiopathology