title: Can proteomics-based diagnostics aid clinical psychiatry?
abstract: Despite major advances in infrastructure and instrumentation, proteomics-driven translational applications have not yet yielded the results that the scientific community has envisaged. In this viewpoint, the perspective of proteomics-based diagnostics in the field of clinical psychiatry is explored. The challenges that proteomics faces in the context of translational approaches are outlined and directions toward a successful clinical implementation are provided. Additional challenges that psychiatric disorders pose for clinical proteomics are highlighted and the potential of proteomics-based, blood tests for psychiatric disorders is being assessed. Proteomics offers a valuable toolkit for clinical translation that needs to be handled in a pragmatic manner and with realistic expectations.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Michaela D
authors.initials: MD
authors.lastname: Filiou
mesh_terms: D015415:Biomarkers; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D011570:Psychiatry / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Blood tests; Clinical proteomics; Diagnostics; Implementation; Psychiatric disorders