title: A new myrsinol-type diterpene polyester from Euphorbia dracunculoides Lam.
abstract: A new myrsinol-type diterpene polyester, 14-deoxo-3β-O-propinoyl-2α,5α,7β,15β-tetra-O-acetyl-14α-O-benzoyl-myrsinol (1), and its known analogue, 14-deoxo-3β-O-prorionyl-5α,15β-di-O-acetyl-7β-O-nicotinoyl-myrsinol-14β-acetate (2), together with a monoterpenoid, pubinernoid A (3), two indole alkaloids, neoechinulin A (4) and dihydroxyisoechinulin A (5), two benzene derivatives, siringin (6) and (3-methoxyphenyl) acetic acid (7), were isolated from the 70% acetone extract of the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated on the basis of spectroscopic evidence and comparison with literature reports. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra. Among them, compounds 4 and 5 were first obtained from the plant source. In addition, the (13)C NMR data of compound 2 was reported for the first time.
authors.affiliation: a College of Chemistry and Chemical Engineering, Yunnan Normal University , Kunming 650500 , P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Yu-Qian
authors.initials: YQ
authors.lastname: Chi
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Ouyang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zang
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Pei
authors.initials: P
authors.lastname: Cao
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D045744:Cell Line, Tumor / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004224:Diterpenes; D011091:Polyesters
keywords: Euphorbia dracunculoides; diterpene polyester; myrsinol