title: Evaluation of lipid peroxidation and oxidative DNA damage in patients with periodontitis and hyperlipidemia.
abstract: BACKGROUND
  The purpose of this study is to determine the serum levels of malondialdehyde (MDA), as a lipid peroxidation marker, and 8-hydroxydeoxyguanosine (8-OHdG), as an oxidative DNA damage marker, in patients with chronic periodontitis (CP) and hyperlipidemia.
  
  
  METHODS
  A total of 74 individuals were divided into four age- and sex-matched groups: 18 patients with hyperlipidemia and CP (HLp), 18 periodontally healthy patients with hyperlipidemia (HLh), 19 systemically healthy individuals with CP (Cp), and 19 systemically and periodontally healthy controls (Ch). Clinical periodontal parameters were measured, and serum lipids, MDA, and 8-OHdG levels were assessed in blood samples.
  
  
  RESULTS
  8-OHdG, MDA, probing depth, clinical attachment level, and percentage of sites bleeding on probing (BOP) were significantly higher in the HLp group than the Cp group. In the hyperlipidemic group, BOP was significantly correlated with total cholesterol, the ratio of total cholesterol to high-density lipoprotein cholesterol, and 8-OHdG levels. A significant correlation between 8-OHdG and MDA was also observed in the hyperlipidemia group.
  
  
  CONCLUSIONS
  In this study, serum MDA and 8-OHdG were found to be highest in the HLp group. The increased levels of MDA and 8-OHdG in HLp patients may be a result of a harmful oxidative status in association with hyperlipidemia and periodontitis.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, University of Süleyman Demirel, Isparta, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Fentoğlu
authors.forename: F Yeşim
authors.initials: FY
authors.lastname: Kırzıoğlu
authors.forename: Memduha Tözüm
authors.initials: MT
authors.lastname: Bulut
authors.forename: Duygu
authors.initials: D
authors.lastname: Kumbul Doğuç
authors.forename: Esin
authors.initials: E
authors.lastname: Kulaç
authors.forename: Canan
authors.initials: C
authors.lastname: Önder
authors.forename: Meral
authors.initials: M
authors.lastname: Günhan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood* / Q000235:genetics; D004249:DNA Damage / Q000502:physiology*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000235:genetics; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017622:Periodontal Attachment Loss / Q000097:blood / Q000235:genetics; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000235:genetics; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D014280:Triglycerides; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002784:Cholesterol; D003849:Deoxyguanosine
keywords: Chronic periodontitis; deoxyguanosine; hyperlipidemias; lipids; malondialdehyde; oxidative stress