title: [Association between gingival crevicular fluid leptin level and periodontal parameters in patients with aggressive periodontitis].
abstract: OBJECTIVE
  To determine the level of leptin in gingival crevicular fluid (GCF) of patients with aggressive periodontitis (AgP) and to analyze the relationship between leptin and periodontal cilinical parameters.
  
  
  METHODS
  Fifty-four patients with AgP and 30 healthy controls were recruited. Detailed clinical examinations were conducted, and clinical parameters such as bleeding index (BI), probing depth (PD), attachment loss (AL) were recorded. Two teeth were selected as test teeth in each subject, one from posterior area and the other from anterior region. The level of GCF leptin was measured by enzyme linked immunosorbent assay.
  
  
  RESULTS
  The level of GCF leptin in AgP patients was significantly lower than that of control subjects [(16.5±4.6) ng vs.(26.0±6.0) ng, P < 0.05]. The level of GCF leptin was negatively related to BI (-0.306, P < 0.01), PD (-0.346, P < 0.01) and AL (-0.250, P < 0.01).
  
  
  CONCLUSIONS
  AgP patients have significantly decreased level of GCF leptin and the level of leptin was negatively related to BI, PD and AL.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Yunyu
authors.initials: Y
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Shi
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Email: kqhxmeng@bjmu.edu.cn.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Meng
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D020738:Leptin / Q000032:analysis*; D008297:Male; D010512:Periodontal Index
chemical_list: D020738:Leptin