title: New sesquiterpenoids and a diterpenoid from Alpinia oxyphylla.
abstract: The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7-12. The inhibitory effects of compounds 1-12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. HL1215mj@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Hou
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. gding@implad.ac.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. blguo@implad.ac.cn.
authors.forename: Baolin
authors.initials: B
authors.lastname: Guo
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. whhuang@implad.ac.cn.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. zhangxj1130@163.com.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. szy0678@126.com.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Sun
authors.affiliation: The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. xiangfenshi@163.com.
authors.forename: Xiangfen
authors.initials: X
authors.lastname: Shi
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D066244:Proton Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes