title: Targeted therapy with propranolol and metronomic chemotherapy combination: sustained complete response of a relapsing metastatic angiosarcoma.
abstract: We report here a case of a 69-year-old woman with a relapsing metastatic angiosarcoma treated with a combination of metronomic chemotherapy and propranolol. The beta blockers were added since the tumour was positive for betaadrenergic receptor. A complete response was quickly obtained and lasted for 20 months. With this case, the combination of metronomic chemotherapy and propranolol in angiosarcoma warrants additional studies and illustrates the potential of metronomics to generate innovative yet inexpensive targeted therapies for both high-income and low-/middle-income countries.
authors.affiliation: Department of Medical and Pediatric Oncology, Tata Memorial Centre, Mumbai 400 012, India ; Metronomics Global Health Initiative, Marseille, France.
authors.forename: Shripad
authors.initials: S
authors.lastname: Banavali
authors.affiliation: Metronomics Global Health Initiative, Marseille, France ; Aix Marseille Université, Inserm, CRO2 UMR_S 91, Marseille 13005, France.
authors.forename: Eddy
authors.initials: E
authors.lastname: Pasquier
authors.affiliation: Metronomics Global Health Initiative, Marseille, France ; Aix Marseille Université, Inserm, CRO2 UMR_S 91, Marseille 13005, France ; Service d'Hématologie & Oncologie Pédiatrique, AP-HM, Marseille 13005, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Andre
keywords: angiosarcoma; beta-blockers; celecoxib; cyclophosphamide; drug repositioning; etoposide; metronomic chemotherapy; palliative treatment; propranolol