title: The role of the cell-cell interactions in cancer progression.
abstract: In the field of cancer research, scientific investigations are based on analysing differences in the secretome, the proteome, the transcriptome, the expression of cell surface molecules, and the deregulation of signal transduction pathways between neoplastic and normal cells. Accumulating evidence indicates a crucial role in carcinogenesis concerning not only stromal cells but also normal cells from target organs and tissue where tumours emerge. The tumour microenvironment (TME) definitively plays an important role in regulating neighbouring cell behaviour. To date, limited attention has been focused upon interactions between cancer cells and normal cells. This review concentrates on the interactions between stromal and healthy cells from the TME in cancer development. In the article, the authors also describe mutations, genes and proteins expression pattern that are involved in tumour development in target organ.
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kamińska
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
authors.forename: Zofia F
authors.initials: ZF
authors.lastname: Bielecka
authors.forename: Ewa
authors.initials: E
authors.lastname: Bartnik
authors.forename: Camillo
authors.initials: C
authors.lastname: Porta
authors.forename: Fei
authors.initials: F
authors.lastname: Lian
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology*; D002450:Cell Communication / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology
keywords: cancer; cell-cell interactions; stromal cells; tumour microenvironment