title: [Clinical features of childhood hemophagocytic syndrome and its association with human parvovirus B19 infection].
abstract: OBJECTIVE
  To investigate the association of childhood hemophagocytic syndrome (HPS) with human parvovirus B19 (HPVB19) infection, and to analyze the clinical features of this disease.
  
  
  METHODS
  ELISA and quantitative real-time PCR were used to detect HPVB19-IgM, HPVB19-IgG and HPVB19-DNA in 65 children with HPS (HPS group) and 65 healthy children (control group). The HPS group was divided into HPVB19-infected (n=14) and non-infected (n=51) groups according to the detection results of HPVB19-DNA. The clinical data of two groups were compared.
  
  
  RESULTS
  The positive rate of HPVB19-IgM in the HPS group (26%, 17/65) was significantly higher than that in the control group (9%, 6/65) (P=0.011), and there was no significant difference in the positive rate of HPVB19-IgG between the HPS (38%, 25/65) and control groups (29%, 19/65) (P=0.266). The infection rate of HPVB19 in the HPS group (22%, 14/65) was significantly higher than that in the control group (3%, 2/65) (P=0.001). Compared with the non-infected group, the HPVB19-infected group had significantly lower platelet count and hemoglobin level on admission, significantly more severe liver function damage, a significantly earlier onset time, and a significantly longer course of disease (P<0.05).
  
  
  CONCLUSIONS
  The pathogenesis of HPS may be associated with HPVBl9 infection. HPVBl9-infected children with HPS have more acute onset, more severe clinical manifestations, and a longer disease duration.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. yingchaowang152@163.com.
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Wang
authors.forename: Dong-Jie
authors.initials: DJ
authors.lastname: Liu
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Ma
authors.forename: Man-Ju
authors.initials: MJ
authors.lastname: Liu
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Sheng
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral