title: Advances in the treatment ofHelicobacter pyloriinfection in children.
abstract: In this review we elaborate on two main questions concerning the management ofHelicobacter pyloriinfection in children. First, we focus on who should be treated. In the presence ofHelicobacter pylori(H. pylori)-associated peptic ulcer disease, eradication of the micro-organism is recommended. WhenH. pyloriinfection is detected by biopsy-based methods in the absence of peptic ulcer disease in a child with dyspeptic symptoms, treatment ofH. pyloriinfection may be considered. In infected children whose first degree relatives have gastric cancer, treatment can be offered. A 'test-and-treat' strategy is not and has never been recommended in children. The second issue to address is what the recommended treatments are. ESPGHAN/NASPGHAN recommends that treatment tailored to susceptibility testing should be the first choice in pediatric patients. The duration of therapy should be 10-14 days. Costs, compliance and adverse effects should be taken into account. Checking the result of eradication with a reliable non-invasive test such as the13C urea breath test, is recommended at least 4-8 weeks following completion of therapy.
authors.affiliation: Saint Antoine Pediatric Clinic, Hôpital Saint Vincent de Paul, Groupement des Hôpitaux de l'Institut Catholique de Lille (GH-ICL), Faculté de Médecine & Maïeutique, Lille-France (Nicolas Kalach).
authors.forename: Nicolas
authors.initials: N
authors.lastname: Kalach
authors.affiliation: Department of Pediatric Gastroenterology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium (Patrick Bontems, Samy Cadranel).
authors.forename: Patrick
authors.initials: P
authors.lastname: Bontems
authors.affiliation: Department of Pediatric Gastroenterology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium (Patrick Bontems, Samy Cadranel).
authors.forename: Samy
authors.initials: S
authors.lastname: Cadranel
keywords: Keywords Helicobacter pylori; child; treatment