title: Thiabendazole inhibition of venom necrosis.
abstract: Thiabendazole (200 mcg/ml) completely inibited the tissue damaging activity of cotton-mouth moccasin venom (300 mcg/ml) when incubated together for one hour at room temperature and injected intradermally into the guinea pig. Thiabendazole (0.15 ml of 200 mcg/ml) injected immediately after the venom decreased tissue damage from cottonmouth moccasin venom (0.05 ml of 600 mcg/ml). Thiabendazole or other chelating agents may be of future value in decreasing tissue damage from venoms containing proteolytic enzymes. The inhibition of proteolytic activity as demonstrated in the designs of this paper do not necessarily prove that this is the drug's mechanism of anthelmintic or antifungal activity. It is known that thiabendazole has a lethal effect on certain nematodes and fungi.
authors.forename: O J
authors.initials: OJ
authors.lastname: Stone
authors.forename: C J
authors.initials: CJ
authors.lastname: Willis
authors.forename: J F
authors.initials: JF
authors.lastname: Mullins
mesh_terms: D017836:Agkistrodon; D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003435:Crotalid Venoms / Q000633:toxicity*; D006168:Guinea Pigs; D008297:Male; D009336:Necrosis / Q000188:drug therapy / Q000209:etiology; D010447:Peptide Hydrolases / Q000187:drug effects / Q000378:metabolism; D013827:Thiabendazole / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D002614:Chelating Agents; D003435:Crotalid Venoms; D010447:Peptide Hydrolases; D013827:Thiabendazole