title: The pancreatic cancer microenvironment: an immunologic battleground.
abstract: Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy.
authors.affiliation: Department of Surgery; University of Washington ; Seattle, WA USA.
authors.forename: Venu G
authors.initials: VG
authors.lastname: Pillarisetty
keywords: IDO; PD-1; immune checkpoints; myeloid cells; regulatory T cells