title: Impact of chronic kidney disease on the outcomes of transcatheter aortic valve implantation: results from the FRANCE 2 registry.
abstract: OBJECTIVE
  The aim of this study was to assess the influence of chronic kidney disease (CKD) classification on clinical outcomes in patients undergoing transcatheter aortic valve implantation (TAVI).
  
  
  RESULTS
  Data of 2,929 consecutive patients undergoing TAVI in the FRANCE 2 registry were analysed. Patients were divided into five groups: CKD 1+2, 3a, 3b, 4, and 5. Both 30-day and one-year mortality rates were significantly increased and positively correlated with CKD severity in all groups. After adjusting for significant influential confounders in a Cox regression multivariate model, CKD 4 and 5 were associated with increased risk of both 30-day mortality and one-year mortality when compared with CKD 1+2 as the reference. This higher mortality was predominantly driven by renal failure and infection in patients with CKD 4 and 5, respectively. Procedural success rate in CKD 5 was significantly lower than that in other groups. All CKD patients trended towards a higher incidence of acute kidney injury (AKI), in parallel with the degree of CKD severity.
  
  
  CONCLUSIONS
  Classification of CKD stages before TAVI allows risk stratification for 30-day and one-year clinical outcomes. CKD 3b, 4 and 5 correlate with poor outcome and are considered a significant risk for TAVI.
authors.affiliation: Centre Hospitalier Universitaire (CHU) Henri Mondor, Créteil, France.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Oguri
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Gauthier
authors.initials: G
authors.lastname: Mouillet
authors.forename: Martine
authors.initials: M
authors.lastname: Gilard
authors.forename: Marc
authors.initials: M
authors.lastname: Laskar
authors.forename: Helene
authors.initials: H
authors.lastname: Eltchaninoff
authors.forename: Jean
authors.initials: J
authors.lastname: Fajadet
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Patrick
authors.initials: P
authors.lastname: Donzeau-Gouge
authors.forename: Pascal
authors.initials: P
authors.lastname: Leprince
authors.forename: Alain
authors.initials: A
authors.lastname: Leguerrier
authors.forename: Alain
authors.initials: A
authors.lastname: Prat
authors.forename: Michel
authors.initials: M
authors.lastname: Lievre
authors.forename: Karine
authors.initials: K
authors.lastname: Chevreul
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Dubois-Rande
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Teiger
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D005602:France; D006801:Humans; D012042:Registries; D051437:Renal Insufficiency / Q000150:complications; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods; D016896:Treatment Outcome