title: Cutaneous drug reactions in children: a multicentric study.
abstract: BACKGROUND
  According to studies conducted in outpatients, it is estimated that 2.5% of children who are treated with a drug will experience a cutaneous adverse drug reaction (CADR).
  
  
  OBJECTIVE
  To analyze the CADR reports involving pediatric patients recorded by three different university hospitals for describing common, serious, and interesting cutaneous drug eruption patterns.
  
  
  METHODS
  For this purpose, the patients' data from three different universities were reviewed retrospectively. Diagnosis was based on history, clinical findings and laboratory test results. The CADRs were classified into seven categories; urticaria, angioedema, maculopapular eruption, fixed drug eruption, erythema multiforme, acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms syndrome.
  
  
  RESULTS
  A total of 122 patients who had CADRs were enrolled in the study. The most frequently detected cutaneous drug reactions were urticaria + angioedema. Most of patients had no previous experience with the same drug and the most common causative agent of CADRs was antimicrobials.
  
  
  CONCLUSIONS
  Since CADRs are relatively rare, the current multicentric study can provide meaningful information about the cutaneous eruption patterns of commonly used drugs.
authors.affiliation: Dermatology Department, Recep Tayyip Erdoğan University Medical Faculty Hospital, Rize, Turkey. Head of the Department: Yunus Saral.
authors.forename: Nursel
authors.initials: N
authors.lastname: Dilek
authors.affiliation: Dermatology Department, Van Research and Training Hospital, Van, Turkey. Head of the Department: Ömer Çalka.
authors.forename: Hatice Uce
authors.initials: HU
authors.lastname: Özkol
authors.affiliation: Dermatology Department, Atatürk Research and Training Hospital, Ankara, Turkey. Head of the Department: Ahmet Metin.
authors.forename: Ayse
authors.initials: A
authors.lastname: Akbaş
authors.affiliation: Dermatology Department, Atatürk Research and Training Hospital, Ankara, Turkey. Head of the Department: Ahmet Metin.
authors.forename: Fadime
authors.initials: F
authors.lastname: Kılınç
authors.affiliation: Microbiology Department, Recep Tayyip Erdoğan University Medical Faculty Hospital, Rize, Turkey. Head of the Department: Osman Birol Özgümüş
authors.forename: Aziz Ramazan
authors.initials: AR
authors.lastname: Dilek
authors.affiliation: Dermatology Department, Recep Tayyip Erdoğan University Medical Faculty Hospital, Rize, Turkey. Head of the Department: Yunus Saral.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Saral
authors.affiliation: Dermatology Department, Atatürk Research and Training Hospital, Ankara, Turkey. Head of the Department: Ahmet Metin.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Metin
authors.affiliation: Dermatology Department, Van Research and Training Hospital, Van, Turkey. Head of the Department: Ömer Çalka.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Çalka
keywords: allergy; children; cutaneous; drug