title: Role of isotretinoin in cancer prevention and management in malignancies associated with xeroderma pigmentosum.
abstract: We report a case of 15 year old female patient of xeroderma pigmentosum with large squamous cell carcinoma on the left side of cheek. She received combination chemotherapy with isotretinoin for a period of 4 months and showed complete clinical remission of tumour. The role of isotretinoin in cancer prevention and management of malignancies associated in xeroderma pigmentosum is also reviewed through literature.
authors.affiliation: Radiation Oncology Department, IRNUM, Peshwar, Pakistan. drjawad67@gmail.com
authors.forename: Sajid
authors.initials: S
authors.lastname: Zaman
authors.forename: Jawad A
authors.initials: JA
authors.lastname: Gillani
authors.lastname: Nabeela
authors.forename: Rauf
authors.initials: R
authors.lastname: Khattak
authors.lastname: Iqbal
authors.forename: Noor
authors.initials: N
authors.lastname: ul Ain
authors.lastname: Zanaib
authors.lastname: Fayyaz
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005153:Facial Neoplasms / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D000077195:Squamous Cell Carcinoma of Head and Neck; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003879:Dermatologic Agents; D015474:Isotretinoin; D002945:Cisplatin; D005472:Fluorouracil