title: Mutational profiling of second primary lung cancers in patients who have received radiation for the treatment of Hodgkin's disease.
abstract: Lung cancer (LC) represents the most common solid tumor in survivors of Hodgkin's disease (HD), and the assessment of the mutational status of oncogenic driver mutations in LC is now standard. We compiled clinical and mutation data (EGFR, KRAS, and ALK) from the medical records of patients with LC and a remote history of HD. 13 cases of LC following HD were seen, including seven with mutational data. Two had EGFR mutations, none had KRAS mutations or ALK translocations. Our conclusions are limited by the small sample size, however this report reinforces the need to identify driver mutations in lung cancers.
authors.affiliation: Department of Internal Medicine, Ohio State University , Columbus, OH , USA ,1.
authors.forename: David Alan
authors.initials: DA
authors.lastname: Bond
authors.forename: Neil
authors.initials: N
authors.lastname: Dunavin
authors.forename: Gregory Alan
authors.initials: GA
authors.lastname: Otterson
mesh_terms: D000293:Adolescent; D000328:Adult; D004252:DNA Mutational Analysis; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000235:genetics*; D055815:Young Adult
keywords: ALK; EGFR; Hodgkin's; KRAS; Lung adenocarcinoma; Second malignancy