title: Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: application in pancreatic cancers.
abstract: Pancreatic cancer is a disease with a significantly poor prognosis. Despite modern advances in other medical, surgical, and oncologic therapy, the outcome from pancreatic cancer has improved little over the last 40 years. To improve the management of this difficult disease, trials investigating the use of dietary and parenteral fish oils rich in omega-3 (ω-3) fatty acids, exhibiting proven anti-inflammatory and anticarcinogenic properties, have revealed favorable results in pancreatic cancers. Proteomics is the large-scale study of proteins that attempts to characterize the complete set of proteins encoded by the genome of an organism and that, with the use of sensitive mass spectrometric-based techniques, has allowed high-throughput analysis of the proteome to aid identification of putative biomarkers pertinent to given disease states. These biomarkers provide useful insight into potentially discovering new markers for early detection or elucidating the efficacy of treatment on pancreatic cancers. Here, our review identifies potential proteomic-based biomarkers in pancreatic cancer relating to apoptosis, cell proliferation, angiogenesis, and metabolic regulation in clinical studies. We also reviewed proteomic biomarkers from the administration of ω-3 fatty acids that act on similar anticarcinogenic pathways as above and reflect that proteomic studies on the effect of ω-3 fatty acids in pancreatic cancer will yield favorable results.
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK Franscois_gerald@yahoo.com.
authors.forename: Franscois
authors.initials: F
authors.lastname: Runau
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK.
authors.forename: Ali
authors.initials: A
authors.lastname: Arshad
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK.
authors.forename: John
authors.initials: J
authors.lastname: Isherwood
authors.affiliation: Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
authors.forename: Leonie
authors.initials: L
authors.lastname: Norris
authors.affiliation: Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
authors.forename: Lynne
authors.initials: L
authors.lastname: Howells
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Metcalfe
authors.affiliation: Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, UK.
authors.forename: Ashley
authors.initials: A
authors.lastname: Dennison
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D005395:Fish Oils
keywords: fish oils; omega-3 fatty acids; pancreatic cancer; proteomics