title: Post-spike hyperpolarization participates in the formation of auditory behavior-related response patterns of inferior collicular neurons in Hipposideros pratti.
abstract: To probe the mechanism underlying the auditory behavior-related response patterns of inferior collicular neurons to constant frequency-frequency modulation (CF-FM) stimulus in Hipposideros pratti, we studied the role of post-spike hyperpolarization (PSH) in the formation of response patterns. Neurons obtained by in vivo extracellular (N=145) and intracellular (N=171) recordings could be consistently classified into single-on (SO) and double-on (DO) neurons. Using intracellular recording, we found that both SO and DO neurons have a PSH with different durations. Statistical analysis showed that most SO neurons had a longer PSH duration than DO neurons (p<0.01). These data suggested that the PSH directly participated in the formation of SO and DO neurons, and the PSH elicited by the CF component was the main synaptic mechanism underlying the SO and DO response patterns. The possible biological significance of these findings relevant to bat echolocation is discussed.
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Li
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Fu
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Yang
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: K
authors.initials: K
authors.lastname: Peng
authors.affiliation: Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan, China.
authors.forename: L-J
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China.
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.affiliation: School of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, China. Electronic address: chenqc@mail.ccnu.edu.cn.
authors.forename: Q-C
authors.initials: QC
authors.lastname: Chen
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D002685:Chiroptera / Q000502:physiology*; D005260:Female; D007245:Inferior Colliculi / Q000502:physiology*; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*
keywords: CF–FM stimulus; Hipposideros pratti; double-on neuron; post-spike hyperpolarization; single-on neuron