title: Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue.
abstract: 3/4-Mercaptobenzyl sulfonates were investigated as aryl thiol catalysts for native chemical ligation (NCL). Whilst catalysing NCL processes at a similar rate to 4-mercaptophenyl acetic acid (MPAA), the increased polarity and solubility of 3-mercaptobenzyl sulfonate in particular may favour its selection as NCL catalyst in many instances.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK. d.macmillan@ucl.ac.uk.
authors.forename: Ben
authors.initials: B
authors.lastname: Cowper
authors.forename: Tsz Mei
authors.initials: TM
authors.lastname: Sze
authors.forename: Bhavesh
authors.initials: B
authors.lastname: Premdjee
authors.forename: Aileen F
authors.initials: AF
authors.lastname: Bongat White
authors.forename: Andrew
authors.initials: A
authors.lastname: Hacking
authors.forename: Derek
authors.initials: D
authors.lastname: Macmillan
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives* / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D020539:Sequence Analysis, Protein; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D010455:Peptides; D013438:Sulfhydryl Compounds; D052216:Glucagon-Like Peptide 1