title: Advances in the targeted therapy of liposarcoma.
abstract: Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted therapy of LPS have provided encouraging data during recent years. This review will provide an overview of the advances in our understanding of LPS and summarize the results of recent trials with novel therapies targeting different genetic and molecular aberrations for different subtypes of LPS.
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Guan
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Xiongfei
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Haohao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Haiyong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Medicine Oncology, Zhejiang Cancer Hospital, Zhejiang, People's Republic of China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Li
authors.affiliation: Clinical Research Center, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Lisong
authors.initials: L
authors.lastname: Teng
keywords: myxoid; pleomorphic; round cell; soft-tissue sarcoma; well-/dedifferentiated