title: SCFTIR1/AFB-based auxin perception: mechanism and role in plant growth and development.
abstract: Auxin regulates a vast array of growth and developmental processes throughout the life cycle of plants. Auxin responses are highly context dependent and can involve changes in cell division, cell expansion, and cell fate. The complexity of the auxin response is illustrated by the recent finding that the auxin-responsive gene set differs significantly between different cell types in the root. Auxin regulation of transcription involves a core pathway consisting of the TIR1/AFB F-box proteins, the Aux/IAA transcriptional repressors, and the ARF transcription factors. Auxin is perceived by a transient coreceptor complex consisting of a TIR1/AFB protein and an Aux/IAA protein. Auxin binding to the coreceptor results in degradation of the Aux/IAAs and derepression of ARF-based transcription. Although the basic outlines of this pathway are now well established, it remains unclear how specificity of the pathway is conferred. However, recent results, focusing on the ways that these three families of proteins interact, are starting to provide important clues.
authors.affiliation: Howard Hughes Medical Institute and Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salehin
authors.affiliation: Howard Hughes Medical Institute and Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093.
authors.forename: Rammyani
authors.initials: R
authors.lastname: Bagchi
authors.affiliation: Howard Hughes Medical Institute and Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093 mestelle@ucsd.edu.
authors.forename: Mark
authors.initials: M
authors.lastname: Estelle
mesh_terms: D018506:Gene Expression Regulation, Plant / Q000502:physiology; D007210:Indoleacetic Acids / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000235:genetics / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*
chemical_list: D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D010940:Plant Proteins