title: Demyelinating CMT--what's known, what's new and what's in store?
abstract: Inherited neuropathies known collectively as Charcot-Marie-Tooth disease are one of the most common inherited neurological conditions affecting ∼1 in 2500 people. A heterogenous disorder, CMT is divided into subtypes based on the pattern of inheritance and also by neurophysiological studies. Despite the clinical similarities among patients with demyelinating CMT, it is recognized that this group of disorders is both genetically and phenotypically heterogenous. Understanding the pathogenesis of these disorders requires an intimate knowledge of normal myelin development and homeostasis. Improvements in genetic testing techniques over the last 20 years have contributed majorly to the identification of specific genes, proteins, and molecular pathways that are providing the basis for understanding the disease processes and developing rational approaches to therapy.
authors.affiliation: Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa, IA 52242, USA. Electronic address: kathryn-brennan@uiowa.edu.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Brennan
authors.affiliation: Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa, IA 52242, USA. Electronic address: yunhong-bai@uiowa.edu.
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Neurology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa, IA 52242, USA. Electronic address: Michael-shy@uiowa.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Shy
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000145:classification / Q000235:genetics / Q000473:pathology; D003711:Demyelinating Diseases / Q000145:classification / Q000235:genetics / Q000473:pathology; D006801:Humans; D009154:Mutation
keywords: Charcot–Marie–Tooth disease; Cx32; Demyelinating neuropathies; Inherited neuropathies; MPZ; PMP22; Unfolded protein response