title: Biogenesis and function of the NGF/TrkA signaling endosome.
abstract: Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons. In recent years, the signaling endosome model has been used to describe the sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde transport of NGF/TrkA-containing endosomes from the axon terminal to the cell body for activation of NGF-inducible gene expression responsible for neuronal survival and development. Here, we review the biogenesis and function of NGF, TrkA, and the signaling endosome and discuss possible roles of Rab GTPases in the biogenesis and trafficking of signaling endosomes.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: M Caleb
authors.initials: MC
authors.lastname: Marlin
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Guangpu
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002470:Cell Survival / Q000502:physiology; D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020917:Receptor, trkA / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C502240:NGF protein, human; D020932:Nerve Growth Factor; D020917:Receptor, trkA; D020691:rab GTP-Binding Proteins
keywords: Endocytosis; Membrane trafficking; NGF; Neurotrophin; Rab; Retrograde transport; Signaling endosome; TrkA