title: The inverse autotransporter family: intimin, invasin and related proteins.
abstract: Intimin and invasin are adhesins and central virulence factors of attaching and effacing bacteria, such as enterohaemorrhagic Escherichia coli, and enteropathogenic Yersiniae, respectively. These proteins are prototypes of a large family of adhesins distributed widely in Gram-negative bacteria. It is now evident that this protein family represents a previously unrecognized autotransporter secretion system, termed type Ve secretion. In contrast to classical autotransport, where the transmembrane β-barrel domain or translocation unit is C-terminal to the extracellular region or passenger domain, type Ve-secreted proteins have an inverted topology with the passenger domain C-terminal to the translocation unit; hence the term inverse autotransporter. This minireview covers the recent advances in elucidating the structure and biogenesis of inverse autotransporters.
authors.affiliation: Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
authors.forename: Jack C
authors.initials: JC
authors.lastname: Leo
authors.affiliation: Interfaculty Institute for Microbiology and Infection Medicine, University Clinics Tübingen, 72076 Tübingen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Oberhettinger
authors.affiliation: Interfaculty Institute for Microbiology and Infection Medicine, University Clinics Tübingen, 72076 Tübingen, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Schütz
authors.affiliation: Department of Biosciences, University of Oslo, 0316 Oslo, Norway; Max Planck Institute for Developmental Biology, Department of Protein Evolution, 72076 Tübingen, Germany. Electronic address: dirk.linke@ibv.uio.no.
authors.forename: Dirk
authors.initials: D
authors.lastname: Linke
mesh_terms: D018829:Adhesins, Bacterial / Q000737:chemistry* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D037521:Virulence Factors / Q000737:chemistry / Q000378:metabolism
chemical_list: D018829:Adhesins, Bacterial; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D037521:Virulence Factors; C053476:invasin, Yersinia; C073819:eaeA protein, E coli
keywords: Autotransport; Bacterial adhesion; Intimin; Invasin; Type Ve secretion