title: What's hot, what's new at WTC--basic science.
abstract: The World Transplant Congress of 2014 presented a broad swath of science that touched on many disparate aspects of cell and organ transplantation, molecular and cellular immunology, systems biology, development, technology and translation into humans. A number of themes emerged this year. B cell biology and antibody chemistry were prominent, as they have been for several years. T cells, co-stimulatory blockade and regulatory T cells continue to dominate many aspects of immune research. Many new aspects of monocyte, macrophage, NK cell and NK T cell development, biology and regulation are now being explored. Diverse aspects of organ injury and the acute and chronic responses to injury are being investigated with new techniques, new targets and a resurgent vigor. Novel advances in xenotransplantation and experimental tolerance garnered much attention. Newer investigations in microbiota and nanotechnology promise significant gains in the near future. Lastly the 'omics of DNA, RNA, proteins, metabolites, bacteria and enzyme actions promise new understanding in biological systems and how to control those systems.
authors.affiliation: Departments of Surgery and Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD.
authors.forename: J S
authors.initials: JS
authors.lastname: Bromberg
mesh_terms: D001402:B-Lymphocytes; D006084:Graft Rejection; D006801:Humans; D048088:Informatics / Q000639:trends*; D064307:Microbiota; D036103:Nanotechnology / Q000639:trends*; D016377:Organ Transplantation / Q000639:trends*; D015427:Reperfusion Injury; D033581:Stem Cell Transplantation; D049490:Systems Biology / Q000639:trends*
keywords: Alloantibody; B cell biology; basic (laboratory) research/science; complement biology; immune regulation; immunobiology; ischemia reperfusion injury (IRI); regenerative medicine; xenotransplantation