title: [Tumor size and prognosis in patients with Wilms tumor].
abstract: OBJECTIVE
  Investigate the relationship of the tumor volume after preoperative chemotherapy (TVAPQ) and before preoperative chemotherapy (TVBPQ) with overall survival at two and at five years, and lifetime.
  
  
  METHODS
  Our sample consisted of consecutive patients evaluated in the period from 1989 to 2009 in an Onco-Hematology Service. Clinical, histological and volumetric data were collected from the medical records. For analysis, chi-square, Kaplan-Meier, log-rank and Cox regression tests were used.
  
  
  RESULTS
  The sample consisted of 32 patients, 53.1% were male with a median age at diagnosis of 43 months. There was a significant association between TVAPQ >500 mL and the difference between the TVBPQ and TVAPQ (p=0.015) and histologic types of risk (p=0.008). It was also verified an association between the difference between the TVBPQ and TVAPQ and the predominant stromal tumor (p=0.037). When assessing the TVAPQ of all patients, without a cutoff, there was an association of the variable with lifetime (p=0.013), i.e., for each increase of 10 mL in TVAPQ there was an average increase of 2% in the risk of death.
  
  
  CONCLUSIONS
  Although our results indicate that the TVAPQ could be considered alone as a predictor of poor prognosis regardless of the cutoff suggested in the literature, more studies are needed to replace the histology and staging by tumor size as best prognostic variable.
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Valentina Oliveira
authors.initials: VO
authors.lastname: Provenzi
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Rafael Fabiano Machado
authors.initials: RF
authors.lastname: Rosa
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Rosana Cardoso Manique
authors.initials: RC
authors.lastname: Rosa
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.
authors.forename: Adriana Vial
authors.initials: AV
authors.lastname: Roehe
authors.affiliation: Grupo Hospitalar Conceição (GHC), Porto Alegre, RS, Brasil.
authors.forename: Pedro Paulo Albino
authors.initials: PP
authors.lastname: dos Santos
authors.affiliation: Grupo Hospitalar Conceição (GHC), Porto Alegre, RS, Brasil.
authors.forename: Fabrízia Rennó Sodero
authors.initials: FR
authors.lastname: Faulhaber
authors.affiliation: Hospital Moinhos de Vento (HMV), Porto Alegre, RS, Brasil.
authors.forename: Ceres Andréia Vieira
authors.initials: CA
authors.lastname: de Oliveira
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil. Electronic address: paulozen@ufcspa.edu.br.
authors.forename: Paulo Ricardo Gazzola
authors.initials: PR
authors.lastname: Zen
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D047368:Tumor Burden; D009396:Wilms Tumor / Q000401:mortality* / Q000473:pathology* / Q000628:therapy
keywords: Análise de sobrevida; Drug therapy; Organ size; Prognosis; Prognóstico; Quimioterapia; Survival analysis; Tamanho do órgão; Tumor de Wilms; Wilms tumor