title: Targets Involved in Cardioprotection by the Non-Anesthetic Noble Gas Helium.
abstract: Research data from the past decade indicate that noble gases like xenon and helium exert profound cardioprotection when applied before, during or after organ ischemia. Of all noble gases, especially helium, has gained interest in the past years because it does not have an anesthetic "side effect" like xenon, allowing application of this specific gas in numerous clinical ischemia/reperfusion situations. Because helium has several unique characteristics and no hemodynamic side effects, helium could be administered in severely ill patients. Investigations in animals as well as in humans have proven that this noble gas is not completely inert and can induce several biological effects. Though the underlying molecular mechanisms of helium-induced cardiac protection are still not yet fully understood, recently different signaling pathways have been elucidated.
authors.affiliation: Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Academic Medical Center (AMC), University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. N.C.Hauck@amc.uva.nl.
authors.forename: Nina C
authors.initials: NC
authors.lastname: Weber
authors.forename: Kirsten F
authors.initials: KF
authors.lastname: Smit
authors.forename: Markus W
authors.initials: MW
authors.lastname: Hollmann
authors.forename: Benedikt
authors.initials: B
authors.lastname: Preckel
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006371:Helium / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D006371:Helium