title: Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung.
abstract: BACKGROUND
  The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis.
  
  
  METHODS
  Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs).
  
  
  RESULTS
  The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P=0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P=0.019) and histological grading (P<0.001). NSCLC with MTSS1 downregulation (<20%) showed a significantly worse outcome (P=0.007). This proved to be an independent prognostic factor in squamous cell carcinomas (SCCs; P=0.041), especially in early cancer stages (P=0.006).
  
  
  CONCLUSIONS
  The metastasis suppressor 1 downregulation could thus serve as a stratifying marker for adjuvant therapy in early-stage SCC of the lung.
authors.affiliation: Department of Surgical Pathology, Institute of Pathology, University Medical Center Freiburg, Breisacher Strasse 115a, D-79106 Freiburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kayser
authors.affiliation: Department of Surgical Pathology, Institute of Pathology, University Medical Center Freiburg, Breisacher Strasse 115a, D-79106 Freiburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Csanadi
authors.affiliation: Department of Surgical Pathology, Institute of Pathology, University Medical Center Freiburg, Breisacher Strasse 115a, D-79106 Freiburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Kakanou
authors.affiliation: Department of Pneumonology, University Medical Center Freiburg, Kilianstrasse 5, D-79106 Freiburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Prasse
authors.affiliation: Department of Surgical Pathology, Institute of Pathology, University Medical Center Freiburg, Breisacher Strasse 115a, D-79106 Freiburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kassem
authors.affiliation: Department of Gynecology and Obstetrics, University Medical Center Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Stickeler
authors.affiliation: Department of Thoracic Surgery, University Medical Center Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Passlick
authors.affiliation: Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, PO Box 616, NL-6200 MD Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Zur Hausen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D016019:Survival Analysis; D046888:Tissue Array Analysis
chemical_list: C486778:MTSS1 protein, human; D008840:Microfilament Proteins; D009363:Neoplasm Proteins