title: Venous sinus thrombosis in a child with nephrotic syndrome: a case report and literature review.
abstract: Nephrotic syndrome is associated with a hypercoagulable state and an increased risk of thromboembolic complications. Cerebral venous sinus thrombosis is a rare complication of nephrotic syndrome, with few cases described in the literature, although the disease may be under-diagnosis. The true incidence of cerebral venous sinus thrombosis may be underestimated because many events are asymptomatic or are not diagnosed in time. Here, we describe the case of a male child, 2 years and 10 months old, with nephrotic syndrome presenting with headache, epileptic seizures and sensory inhibition who was diagnosed with superior sagittal and transverse sinuses thrombosis. An international literature review was performed with a defined search strategy in the PubMed, SciELO and Lilacs databases using the terms 'nephrotic syndrome' and 'cerebral sinovenous thrombosis'. The diagnosis of venous thrombosis should be considered in any patient with nephrotic syndrome who presents with neurological signs and symptoms, as early clinical diagnosis promotes favorable outcomes.
authors.affiliation: Unidade de Terapia Intensiva Neonatal e Pediátrica, Hospital Santa Isabel, Ubá, MG, Brasil.
authors.forename: Ronaldo Afonso
authors.initials: RA
authors.lastname: Torres
authors.affiliation: Curso Acadêmico de Medicina, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, MG, Brasil.
authors.forename: Bruna Ribeiro
authors.initials: BR
authors.lastname: Torres
authors.affiliation: Serviço de Nefrologia Infantil, Hospital Santa Isabel, Ubá, MG, Brasil.
authors.forename: Alessandra Soares Rocha
authors.initials: AS
authors.lastname: de Castilho
authors.affiliation: Serviço de Radiologia, Hospital Santa Isabel, Ubá, MG, Brasil.
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Honorato
mesh_terms: D002675:Child, Preschool; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*; D012640:Seizures / Q000209:etiology; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology*