title: Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate.
abstract: Perfluorooctane sulfonate (PFOS) is an endocrine disruptor, whose exposure can induce several alterations on the reproductive axis activity in males during adulthood. This study was undertaken to evaluate the possible role of serotonin and neuropeptide Y (NPY) on the disruption of the hypothalamic-pituitary-testicular (HPT) axis induced by PFOS in adult male rats. For that, adult male rats were orally treated with 0.5; 1.0; 3.0 and 6.0mg of PFOS/kg/day for 28 days. After PFOS exposure, serotonin concentration increased in the anterior and mediobasal hypothalamus as well as in the median eminence. The metabolism of this amine (expressed as the ratio 5-hydroxyindolacetic acid (5-HIAA)/serotonin) was diminished except in the anterior hypothalamus, with the doses of 3.0 and 6.0mg/kg/day, being this dose 0.5mg/kg/day in the median eminence. In general terms, PFOS-treated rats presented a decrease of the hypothalamic concentration of the gonadotropin releasing hormone (GnRH) and NPY. A diminution of the serum levels of the luteinizing hormone (LH), testosterone and estradiol were also shown. These results suggest that both serotonin and NPY could be involved in the inhibition induced by PFOS on the reproductive axis activity in adult male rats.
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas S/n, 32004 Ourense, Spain.
authors.forename: S
authors.initials: S
authors.lastname: López-Doval
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas S/n, 32004 Ourense, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Salgado
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas S/n, 32004 Ourense, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Fernández-Pérez
authors.affiliation: Laboratory of Toxicology, Sciences School, University of Vigo, Las Lagunas S/n, 32004 Ourense, Spain. Electronic address: lafuente@uvigo.es.
authors.forename: A
authors.initials: A
authors.lastname: Lafuente
mesh_terms: D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005466:Fluorocarbons / Q000633:toxicity*; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D009478:Neuropeptide Y; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D012701:Serotonin; D013737:Testis / Q000187:drug effects
chemical_list: D017738:Alkanesulfonic Acids; D052244:Endocrine Disruptors; D005466:Fluorocarbons; D012739:Gonadal Steroid Hormones; D009478:Neuropeptide Y; D012701:Serotonin; C076994:perfluorooctane sulfonic acid
keywords: Male; Neuropeptide Y; Oxidative stress; PFOS; Reproductive axis; Serotonin