title: Evaluation of the role of maternal serum high-sensitivity C-reactive protein in predicting early pregnancy failure.
abstract: Maternal serum high-sensitivity C-reactive protein (HSCRP) was evaluated in predicting spontaneous abortion in spontaneous pregnancies presenting with threatened spontaneous abortion. Seventy-one cases of threatened spontaneous abortion (group A) and 71 asymptomatic controls (group B), matched for gestational and maternal age, body mass index and smoking status, were included. Maternal serum samples were evaluated for HCG, progesterone, pregnancy-associated plasma protein-A (PAPP-A) and HSCRP using standard bio-assays. No difference was observed in ultrasound measurements, and median progesterone maternal serum level was significantly lower (P < 0.05) in group A compared with group B. In group A, the median of all ultrasound and maternal serum parameters was significantly lower (P < 0.01) compared with group B. The median gestational sac diameter, volume and median HSCRP and PAPP-A levels were significantly increased (P < 0.05) in group A, with a normal outcome compared with group B, probably owing to the inflammatory reaction associated with intrauterine bleeding. In group A patients destined to abortion, the gestational sac development and corresponding protein synthesis fell before the fetal heart activity stopped; in spontaneous pregnancies, maternal serum HSCRP did not provide additional information for the management of threatened spontaneous abortion but warrants further research in assisted reproduction pregnancies.
authors.affiliation: Department of Obstetrics and Gynaecology, University College Hospital (UCLH), 235 Euston Road, NW1 2BU, London, UK; Academic Department of Obstetrics and Gynaecology, UCL Institute for Women's Health, University College London (UCL), WC1E 6HX, London, UK. Electronic address: e.jauniaux@ucl.ac.uk.
authors.forename: Eric
authors.initials: E
authors.lastname: Jauniaux
authors.affiliation: Department of Clinical Chemistry, Erasme Hospital, Université Libre de Bruxelles (ULB), 808 Route de Lennik, 1070 Brussels, Belgium.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Gulbis
authors.affiliation: Academic Department of Obstetrics and Gynaecology, UCL Institute for Women's Health, University College London (UCL), WC1E 6HX, London, UK.
authors.forename: Amna
authors.initials: A
authors.lastname: Jamil
authors.affiliation: Academic Department of Obstetrics and Gynaecology, UCL Institute for Women's Health, University College London (UCL), WC1E 6HX, London, UK.
authors.forename: Davor
authors.initials: D
authors.lastname: Jurkovic
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D015536:Down-Regulation; D042241:Early Diagnosis; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008131:London / Q000453:epidemiology; D010044:Outpatient Clinics, Hospital; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D012306:Risk; D014463:Ultrasonography; D015854:Up-Regulation; D014592:Uterine Hemorrhage / Q000209:etiology*; D014599:Uterus / Q000000981:diagnostic imaging
chemical_list: D015415:Biomarkers; D011374:Progesterone; D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human
keywords: C-reactive protein; first-trimester; maternal serum; miscarriage; pregnancy