title: X monosomy in a virilized female cat.
abstract: An infertile Siamese female cat was subjected for clinical, histological, cytogenetic and molecular studies due to ambiguous external genitalia (vulva, vagina, rudimentary penis and scrotum-like structure) and masculine behaviour. An elevated oestrogen activity and a detectable level of testosterone were found. The cat underwent laparotomy. The gonads and the uterus were removed and subjected for histological studies, which showed ovaries with corpora lutea and a some primordial follicles. Chromosome studies of lymphocyte and fibroblast cultures, with the use of Giemsa staining, G-banding and whole X chromosome painting by fluorescence in situ hybridization, revealed pure X monosomy. Molecular analysis showed the absence of the SRY gene. Our study revealed for the first time that X monosomy in cats may be associated with virilization, in spite of the lack of the SRY gene.
authors.affiliation: Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Szczerbal
authors.affiliation: Department of Reproduction, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Nizanski
authors.affiliation: Department of Pathology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Dzimira
authors.affiliation: Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Nowacka-Woszuk
authors.affiliation: Department of Reproduction, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Ochota
authors.affiliation: Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Switonski
mesh_terms: D000782:Aneuploidy; D000818:Animals; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D012734:Disorders of Sex Development / Q000662:veterinary*; D005260:Female; D012729:Sex Chromosome Aberrations / Q000662:veterinary*; D014770:Virilism