title: [Allergic contact eczema to a long-used cosmetic: Methylisothiazolinon, a type IV-allergen].
abstract: Methylisothiazolinone was permitted in 2004 as preservative in rinse-off and leave-on products by the European cosmetics directive. This led to a dramatic increase in contact eczemas induced by MI in the past few years. Here, we report a patient who developed a spreading contact eczema of the face, neck and proximal arms mimicking a photodermatosis. The reaction was caused by use of a facial ointment that only recently started to contain MI. Type IV-sensitization to MI was verified by patch testing.
authors.affiliation: Zentrum für Dermatologie, Allergologie und Dermatochirurgie, HELIOS Klinikum Wuppertal, Universität Witten/Herdecke, Heusnerstr. 40, 42283, Wuppertal, Deutschland, noemi.gaebelein-wissing@helios-kliniken.de.
authors.forename: N
authors.initials: N
authors.lastname: Gäbelein-Wissing
authors.forename: P
authors.initials: P
authors.lastname: Lehmann
authors.forename: S C
authors.initials: SC
authors.lastname: Hofmann
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D063465:Skin Cream / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one