title: Why are neurotransmitters neurotoxic? An evolutionary perspective.
abstract: In the CNS, minor changes in the concentration of neurotransmitters such as glutamate or dopamine can lead to neurodegenerative diseases. We present an evolutionary perspective on the function of neurotransmitter toxicity in the CNS. We hypothesize that neurotransmitters are selected because of their toxicity, which serves as a test of neuron quality and facilitates the selection of neuronal pathways. This perspective may offer additional explanations for the reduction of neurotransmitter concentration in the CNS with age, and suggest an additional role for the blood-brain barrier. It may also suggest a connection between the specific toxicity of the neurotransmitters released in a specific region of the CNS, and elucidate their role as chemicals that are optimal for testing the quality of cells in that region.
authors.affiliation: Department of Zoology, Tel-Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Harris
authors.affiliation: Department of Zoology, Tel-Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Meital
authors.initials: M
authors.lastname: Weiss
authors.affiliation: Department of Zoology, Tel-Aviv University, Tel Aviv, 69978, Israel ; Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Amotz
authors.initials: A
authors.lastname: Zahavi