title: [Efficacy of statin on short-term prognosis in elderly patients with acute kidney injury].
abstract: OBJECTIVE
  To evaluate the effects of statins on the short-term prognosis in elderly patients with acute kidney injury (AKI).
  
  
  METHODS
  The data of hospitalized elderly patients with AKI at our hospital from June 2010 to December 2011 were analyzed retrospectively. The etiology, characteristics, prognosis and relative risk factors were examined. They were divided into statin and non-statin groups according to whether or not statins were taken over 3 months before a diagnosis of AKI.
  
  
  RESULTS
  For 377 cases of elderly patients with AKI, serum creatinine (Scr) tmax was around 7.8 days and 2.06 times of peak increased in the level of Scr to baseline. About 24.7% of those were complicated with multiple organ dysfunction syndrome (MODS). Renal function fully recovered within 3 months after AKI in 206 cases (54.6%) of elderly patients with AKI. The renal function recovery rate of patients in statin group (n = 145) was significantly higher than that of those in non-statin group (n = 232) (P < 0.01). And 121 case (32.1%) died within 3 months after AKI. At the end of 3 months after AKI, the doubling of Scr level in statin group was significantly lower than that in non-statin group (P < 0.01). Logistic regression analysis showed that risk factors of mortality within 3 months in elders with AKI were significantly associated with infection and concurrent MODS. The doubling of Scr level after AKI in elders was significantly associated with the level of Scr at a diagnosis of AKI, MODS and the history of chronic kidney disease. The risk of doubling in Scr level was significantly reduced in patients of statin group after AKI (P = 0.02, OR: 0.46; 95% CI: 0.24-0.9).
  
  
  CONCLUSIONS
  The risks of death in elderly patients with AKI are associated with infection and concurrent MODS. Long-term use of statin in elderly patients can significantly reduce the risk of doubling Scr level in surviving patients.
authors.affiliation: Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing 100853, China. Email: qlcheng64@163.com.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Cheng
mesh_terms: D058186:Acute Kidney Injury; D000368:Aged; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007677:Kidney Function Tests; D009102:Multiple Organ Failure; D011379:Prognosis; D051436:Renal Insufficiency, Chronic; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors