title: Seasonality of both bacteremic and nonbacteremic pneumonia coincides with viral lower respiratory tract infections in early childhood, in contrast to nonpneumonia invasive pneumococcal disease, in the pre-pneumococcal conjugate vaccine era.
abstract: We assessed the seasonality of viral lower respiratory tract infections (V-LRI), bacteremic pneumonia, nonbacteremic pneumonia and nonpneumonia invasive pneumococcal diseases (IPD) in the pre-PCV era. Both bacteremic and nonbacteremic pneumonia seasonality peaked in winter, coinciding with V-LRI seasonality, whereas non-pneumonia IPD peaked in autumn before V-LRI increase, suggesting different pathogenesis.
authors.affiliation: The Pediatric Infectious Disease Unit, Soroka University Medical Center The Faculty of Health Sciences, Ben-Gurion University.
authors.forename: Shalom
authors.initials: S
authors.lastname: Ben-Shimol
authors.affiliation: The Pediatric Infectious Disease Unit, Soroka University Medical Center The Faculty of Health Sciences, Ben-Gurion University.
authors.forename: David
authors.initials: D
authors.lastname: Greenberg
authors.affiliation: The Pediatric Infectious Disease Unit, Soroka University Medical Center The Faculty of Health Sciences, Ben-Gurion University.
authors.forename: Guy
authors.initials: G
authors.lastname: Hazan
authors.affiliation: The Faculty of Health Sciences, Ben-Gurion University Laboratory of Clinical Virology, Soroka University Medical Center, Beer-Sheva, Israel.
authors.forename: Yonat
authors.initials: Y
authors.lastname: Shemer-Avni
authors.affiliation: The Pediatric Infectious Disease Unit, Soroka University Medical Center The Faculty of Health Sciences, Ben-Gurion University.
authors.forename: Noga
authors.initials: N
authors.lastname: Givon-Lavi
authors.affiliation: The Pediatric Infectious Disease Unit, Soroka University Medical Center The Faculty of Health Sciences, Ben-Gurion University.
authors.forename: Ron
authors.initials: R
authors.lastname: Dagan
mesh_terms: D016470:Bacteremia / Q000453:epidemiology*; D002675:Child, Preschool; D062665:Epidemiological Monitoring; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D022242:Pneumococcal Vaccines; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology*; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D012621:Seasons; D018074:Vaccines, Conjugate; D014777:Virus Diseases / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: bacteremic pneumonia; invasive pneumococcal diseases; seasonality; viral lower respiratory infections