title: Assessment of liver function and liver fibrosis with dynamic Gd-EOB-DTPA-enhanced MRI.
abstract: OBJECTIVE
  To evaluate the ability of segmental linear fitting analysis of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid liver perfusion magnetic resonance imaging (MRI) to assess liver function and liver fibrosis.
  
  
  METHODS
  Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid liver perfusion MRI was performed in 41 patients, and perfusion estimates were generated by segmental linear fitting analysis of the time-intensity curves. The relationships of Tin, Tout, Kup, and the ratio between the signal intensities of the peak and the last phase with liver fibrosis stage and laboratory measurements of liver function were evaluated.
  
  
  RESULTS
  Serum prealbumin concentration was significantly positively correlated with Kup and the signal intensity ratio and was significantly negatively correlated with Tin and Tout. Tin and Tout were significantly higher and Kup and the signal intensity ratio were significantly lower in patients with advanced fibrosis than those without. Tout was the best predictor of advanced fibrosis, with an area under the receiving operating characteristic curve of 0.843, a sensitivity of 100%, and a specificity of 80%.
  
  
  CONCLUSIONS
  A new procedure of quantifying the hepatocyte-specific uptake of a T1-enhancing contrast agent can be used to assess impaired hepatobiliary function. The parameters obtained from perfusion MRI have the potential to predict advanced fibrosis.
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Pathology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: cjr.wangwu@vip.163.com.
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: Gd-EOB-DTPA; Liver function; MRI; liver fibrosis; perfusion-weighted imaging