title: [Progression of drug delivery system for glaucoma].
abstract: Reduction of intraocular pressure (IOP) by drugs is a major treatment for glaucoma. Clinically, diverse antiglaucoma drugs take effect to decrease the IOP through different mechanisms.However, due to limitations of traditional form of eye drops, the bioavailability of the drug and the patient compliance is lowered, the clinical efficacy is not good and also some toxic and side-effects come out.Otherwise, traditional medication is not suitable for neuroprotective drugs to work on both retina and optic nerve. Drug delivery system has the potential to improve the bioavailability of the drug, prolong the time of drug action, decrease the dosage and frequency of drugs, reduce the side-effects, and improve the patient compliance and efficacy.It is one of the most important studies in glaucoma medication development because it is valuable for patients' neuroprotection.Nowadays, several novel delivery systems have been designed. This review will focus on the progressions of some of the sustained-release antiglaucoma eye drops, polymeric gels, colloidal systems, membrane-controlled drug delivery system, ocular implants, and transscleral drug delivery systems.
authors.affiliation: Henan Eye Institute, Henan Eye Hospital, Zhengzhou 450003, China. Email: xuyan990301@aliyun.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Liu
authors.initials: L
authors.lastname: Lyu
mesh_terms: D001682:Biological Availability; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000493:pharmacokinetics; D009900:Optic Nerve
chemical_list: D003692:Delayed-Action Preparations; D018696:Neuroprotective Agents; D009883:Ophthalmic Solutions