title: Paraoxonase1 192 (PON1 192) gene polymorphism and serum paraoxonase activity in panic disorder patients.
abstract: OBJECTIVE
  Reactive oxygen species (ROS) are involved in the development of certain neuropsychiatric disorders. Paraoxonase 1 (PON1) activity has been suggested to be adversely related to oxidative stress in plasma. The purpose of the present study was to demonstrate the relationship between serum PON1 activity and PON1 192 polymorphism in panic disorder (PD).
  
  
  METHODS
  Fourty-two patients with PD and 46 healthy controls were included in this study. PON1 192 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. PON1 activity was measured by spectrophotometric assay of p-nitrophenol production following the addition of paraoxon.
  
  
  RESULTS
  PON1 192 AA genotype and A allele in PD were significantly higher than in the control group, whereas the B allele was found to be significantly higher in the control group. Patients with panic disorder have lower PON1 activity than the control group.
  
  
  CONCLUSIONS
  The PON1 192 AA genotype may increase the risk of PD depending on lipid peroxidation.
authors.affiliation: Department of Molecular Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Hande
authors.initials: H
authors.lastname: Atasoy
authors.affiliation: Department of Molecular Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Güleç-Yilmaz
authors.affiliation: Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Ergen
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Uzay
authors.initials: U
authors.lastname: Görmüş
authors.affiliation: Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Küçükhüseyin
authors.affiliation: Yeditepe University Hospital, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Dalan
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Kevser Kusat
authors.initials: KK
authors.lastname: Ol
authors.affiliation: Erenkoy Mental Research and Training Hospital, Istanbul, Turkey.
authors.forename: Dicle Bilge
authors.initials: DB
authors.lastname: Ögüt
authors.affiliation: Erenkoy Mental Research and Training Hospital, Istanbul, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Güleç
authors.affiliation: Erenkoy Mental Research and Training Hospital, Istanbul, Turkey.
authors.forename: Buğra
authors.initials: B
authors.lastname: Çetin
authors.affiliation: Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Timirci-Kahraman
authors.affiliation: Department of Neurology, Yeditepe University Hospital, Istanbul, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Örmeci
authors.affiliation: Department of Molecular Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Nazli
authors.initials: N
authors.lastname: Uçunoğlu
authors.affiliation: Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Guldal Inal
authors.initials: GI
authors.lastname: Gultekin
authors.affiliation: Department of Medical Biology, Yeditepe University, Istanbul, Turkey turgay.isbir@yeditepe.edu.tr tisbir@superonline.com.
authors.forename: Turgay
authors.initials: T
authors.lastname: İsbir
mesh_terms: D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D004789:Enzyme Activation; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D016584:Panic Disorder / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: PON; panic disorder; polymorphism