title: Rapid preparation of molecularly imprinted polymers by microwave-assisted emulsion polymerization for the extraction of florfenicol in milk.
abstract: In this study, we proposed a rapid and simple method for the preparation of molecularly imprinted polymers (MIPs) by emulsion polymerization. The polymerization process was accelerated by microwave heating, and the reaction time was greatly shortened. The obtained MIPs were spherical in shape and exhibited a uniform morphology. The MIPs with selectivity and high affinity to florfenicol were successfully applied as solid-phase extraction materials to extract and clean up the florfenicol in milk, followed by liquid chromatography-tandem mass spectrometry (LC-MS) analysis. The parameters affecting the performance of extraction and LC-MS analysis were evaluated. The detection limit of the method was 4.1ngmL(-1). The relative standard deviations of intra- and inter-day were in the range of 3.5-4.7% and 3.9-7.5%, respectively.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Kimchaek University of Technology, Pyongyang 999093, Republic of Korea.
authors.forename: Sunil
authors.initials: S
authors.lastname: Son
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Fengshuang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: dinglan@jlu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Ding
mesh_terms: D000818:Animals; D002434:Cefadroxil / Q000737:chemistry; D002701:Chloramphenicol / Q000737:chemistry; D002853:Chromatography, Liquid; D004655:Emulsions / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D015575:Roxithromycin / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D053719:Tandem Mass Spectrometry; D013696:Temperature; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D004655:Emulsions; D011108:Polymers; D015575:Roxithromycin; D002434:Cefadroxil; D002701:Chloramphenicol; C035534:florfenicol; D013839:Thiamphenicol
keywords: Florfenicol; Liquid chromatography–tandem mass spectrometry; Microwave heating; Milk; Molecularly imprinted polymers