title: (18)F-FDG PET/CT and MRI findings in a patient with anti-GABA(B) receptor encephalitis.
abstract: Autoimmune synaptic encephalitis can occur as paraneoplastic neurological syndromes, which are dysfunctions of the nervous system in cancer patients. One such rare but treatable form is associated with GABAB (γ-aminobutyric acid-B) receptor antibody. We report a 55-year-old man with small cell lung cancer who presented with 3 weeks of progressive seizures, memory impairment, and behavioral disorder. His cerebrospinal fluid anti-GABAB receptor antibody titer was elevated. F-FDG PET/CT revealed pronounced medial temporal hypermetabolism with gross hypometabolism in the rest of the brain. There were no associated abnormalities on MRI. He showed improvement after immunotherapy and chemoradiotherapy.
authors.affiliation: From the Department of Nuclear Medicine, National Key Discipline of Medical Imaging and Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Minggang
authors.initials: M
authors.lastname: Su
authors.forename: Dongkun
authors.initials: D
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Tian
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D020363:Limbic Encephalitis / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010257:Paraneoplastic Syndromes / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D018080:Receptors, GABA-B / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D018080:Receptors, GABA-B; D019788:Fluorodeoxyglucose F18