title: Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).
abstract: In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.
authors.affiliation: Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
authors.forename: Andrea I
authors.initials: AI
authors.lastname: Loewendorf
authors.affiliation: Chief Scientific Officer, The Huntington Medical Research Institutes Pasadena, CA, USA.
authors.forename: Marie
authors.initials: M
authors.lastname: Csete
authors.affiliation: The Children's Hospital of Philadelphia, Children's Institute of Surgical Science Philadelphia, PA, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Flake
keywords: central tolerance; fetal alloresponse; in utero hematopoetic stem cell transplantation; maternal alloresponse; regulatory T cells (T-Regs)