title: 3D printed microfluidic devices with integrated valves.
abstract: We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, USA.
authors.forename: Chad I
authors.initials: CI
authors.lastname: Rogers
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University , Provo, Utah 84602, USA.
authors.forename: Kamran
authors.initials: K
authors.lastname: Qaderi
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, USA.
authors.forename: Adam T
authors.initials: AT
authors.lastname: Woolley
authors.affiliation: Department of Electrical and Computer Engineering, Brigham Young University , Provo, Utah 84602, USA.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Nordin