title: Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease.
abstract: Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has been identified to be essential in T cell activation; however, the role of TIRC7 in aGVHD remains unclear. The purpose of this study was to measure the expression of TIRC7 and T helper (Th) cells in patients with aGVHD before and after treatment. We showed that TIRC7 levels in aGVHD patients were higher than those of healthy controls and markedly declined after treatment. The levels of IFN-γ (Th1), IL-17 (Th17), and IL-22 (Th22) were in accordance with the grade of aGVHD. In addition, TIRC7 levels were also associated with the severity of aGVHD. In conclusion, TIRC7 might be involved in the pathogenesis of aGVHD and TIRC7 level might be an indicator to evaluate the response of patients with aGVHD to treatment.
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xu Zhou, 221002, Jiangsu, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Jianlin
authors.initials: J
authors.lastname: Qiao
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Pan
authors.forename: Qing-yun
authors.initials: QY
authors.lastname: Wu
authors.forename: Jiang
authors.initials: J
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Sang
authors.forename: Zhi-ling
authors.initials: ZL
authors.lastname: Yan
authors.forename: Ling-yu
authors.initials: LY
authors.lastname: Zeng
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Kai-lin
authors.initials: KL
authors.lastname: Xu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018076:DNA, Complementary / Q000097:blood* / Q000276:immunology; D005260:Female; D005786:Gene Expression Regulation; D006086:Graft vs Host Disease / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D025262:Vacuolar Proton-Translocating ATPases / Q000096:biosynthesis / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018076:DNA, Complementary; C472421:TCIRG1 protein, human; D025262:Vacuolar Proton-Translocating ATPases