title: The Spanish Society of Neurology's official clinical practice guidelines for epilepsy. Special considerations in epilepsy: comorbidities, women of childbearing age, and elderly patients.
abstract: BACKGROUND
  The characteristics of some population groups (patients with comorbidities, women of childbearing age, the elderly) may limit epilepsy management. Antiepileptic treatment in these patients may require adjustments.
  
  
  METHODS
  We searched articles in Pubmed, clinical practice guidelines for epilepsy, and recommendations by the most relevant medical societies regarding epilepsy in special situations (patients with comorbidities, women of childbearing age, the elderly). Evidence and recommendations are classified according to the prognostic criteria of Oxford Centre of Evidence-Based Medicine (2001) and the European Federation of Neurological Societies (2004) for therapeutic interventions.
  
  
  CONCLUSIONS
  Epilepsy treatment in special cases of comorbidities must be selected properly to improve efficacy with the fewest side effects. Adjusting antiepileptic medication and/or hormone therapy is necessary for proper seizure management in catamenial epilepsy. Exposure to antiepileptic drugs (AED) during pregnancy increases the risk of birth defects and may affect fetal growth and/or cognitive development. Postpartum breastfeeding is recommended, with monitoring for adverse effects if sedative AEDs are used. Finally, the elderly are prone to epilepsy, and diagnostic and treatment characteristics in this group differ from those of other age groups. Although therapeutic limitations may be more frequent in older patients due to comorbidities, they usually respond better to lower doses of AEDs than do other age groups.
authors.affiliation: Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address: jamauri@telefonica.net.
authors.forename: J A
authors.initials: JA
authors.lastname: Mauri Llerda
authors.affiliation: Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
authors.forename: A
authors.initials: A
authors.lastname: Suller Marti
authors.affiliation: Hospital 12 de Octubre, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: de la Peña Mayor
authors.affiliation: Hospital Universitario Mutua de Terrassa, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Martínez Ferri
authors.affiliation: Hospital Universitario de Donostia, San Sebastián, Guipúzcoa, España.
authors.forename: J J
authors.initials: JJ
authors.lastname: Poza Aldea
authors.affiliation: Hospital Xeral-Cíes, Vigo, Pontevedra, España.
authors.forename: J
authors.initials: J
authors.lastname: Gomez Alonso
authors.affiliation: Hospital Regional Universitario Carlos Haya, Málaga, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Mercadé Cerdá
mesh_terms: D000014:Abnormalities, Drug-Induced; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D015897:Comorbidity; D004347:Drug Interactions / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy*; D019317:Evidence-Based Medicine / Q000592:standards; D005260:Female; D006801:Humans; D009462:Neurology / Q000458:organization & administration*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012307:Risk Factors; D012952:Societies; D013030:Spain
chemical_list: D000927:Anticonvulsants
keywords: Anciano; Comorbidity; Comorbilidad; Elderly; Embarazo; Epilepsia; Epilepsy; Mujer; Pregnancy; Teratogenicidad; Teratogenicity; Women