title: Androgen receptors beyond prostate cancer: an old marker as a new target.
abstract: Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting.
authors.affiliation: Hematology-Oncology, Banner MD Anderson Cancer Center, E. Banner Gateway Drive, Gilbert, Arizona.
authors.forename: Javier
authors.initials: J
authors.lastname: Munoz
authors.affiliation: Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Holcombe Boulevard, Houston, Texas.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Wheler
authors.affiliation: Center for Personalized Cancer Therapy, Division and Hematology and Oncology, Moores Cancer Center, The University of California San Diego, 3855 Health Sciences Drive, La Jolla, California.
authors.forename: Razelle
authors.initials: R
authors.lastname: Kurzrock
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D011944:Receptors, Androgen