title: Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience.
abstract: The effectiveness and short-term safety of recombinant human GH (r-hGH) in acromegaly patients with GH deficiency (GHD) after treatment are not well established. The study includes ten subjects with acromegaly who had GHD treated with r-hGH for 6 months. Control groups consisted of ten age-, gender-, and BMI-matched healthy subjects and ten active acromegaly patients who were treatment naïve. Body composition, quality of life (QoL), muscle strength, lipid profile, and cardiovascular risk factors were assessed in all subjects at baseline, and the same parameters were reassessed after 6 months of therapy with r-hGH in acromegaly with GHD. Repeat magnetic resonance imaging of the sella was performed in treated subjects. Optical colonoscopy was done and biopsies were taken from multiple sites for proliferation indices (Ki67). The median duration of GHD was 17.8 months and dose of r-hGH administered was 5.7±1.5 μg/kg per day. There was improvement in bone mineral content (P=0.01), bone mineral density (P=0.04), muscle strength (P<0.001), total cholesterol (P=0.003), high-density cholesterol (P<0.001), and QoL - score (P=0.005), and reduction in low-density cholesterol (P=0.003) and triglyceride (P=0.004) after treatment. There was no change in lean body mass, total body fat, hsCRP, lipoprotein (a), and fibrinogen levels. There was a modest increase in plasminogen activator inhibitor 1 (P=0.002), but it was lower compared with healthy controls and treatment naïve acromegalics (P=0.007). Six month-r-hGH therapy improves body composition, atherogenic lipid profile, QoL, and muscle strength in GHD patients who had acromegaly. Long-term prospective studies are needed to evaluate the effect of r-hGH therapy in these patients.
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India pinaki_dutta@hotmail.com.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Dutta
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Mahendran
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Reddy
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Kim
authors.initials: K
authors.lastname: Vaiphei
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Kochhar
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Prakamya
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Srinivasan
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Prakash
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Kanchan Kumar
authors.initials: KK
authors.lastname: Mukherjee
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: V N
authors.initials: VN
authors.lastname: Shah
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Girish
authors.initials: G
authors.lastname: Parthan
authors.affiliation: Department of Endocrinology4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, IndiaInternal MedicineCardiologyHematologyHistopathologyGastroenterologyNeurosurgeryPharmacologyRadiodiagnosisPost Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
keywords: GH therapy; acromegaly; growth hormone deficiency