title: [Non-pharmacological treatment - results from Poděbrady].
abstract: OBJECTIVE
  The study was aimed to determine risk factors of atherosclerosis after one month lifestyle intervention in overweight/obese children and also FTO and MC4R gene variants associated with obesity.
  
  
  METHODS
  350 non-diabetic Czech children (age 13.7 ± 2.1 years, 163 ± 10.6 cm hight) was examined. Before and after 4 weeks of lifestyle intervention (comprising a reduction of energy intake), biochemical and anthropometrical measurements were performed.
  
  
  RESULTS
  The mean weight loss achieved was 6.2 ± 2.1 kg (P < 0.001). Significant associations between BMI decrease and FTO and MC4R variants were found. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to the non-carriers (P < 0.0009 for BMI and P < 0.002 for body weight). The differences remain significant after adjustment for sex age and baseline values (P = 0.004 for BMI and P = 0.01 for body weight).
  
  
  CONCLUSIONS
  It is necessary to look for the risk individuals with wrong response to the regime intervention. This individuals is necessary early treat with drugs to prevention clinically complications.Key words: childhood obesity - components of metabolic syndrome - predisposition - response to intervention.
authors.forename: Lukáš
authors.initials: L
authors.lastname: Zlatohlávek
authors.forename: Michal
authors.initials: M
authors.lastname: Vrablík
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Urbanová
authors.forename: Hana
authors.initials: H
authors.lastname: Pejšová
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Hubáček
authors.forename: Richard
authors.initials: R
authors.lastname: Češka
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000235:genetics / Q000628:therapy*; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D005260:Female; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008019:Life Style; D008297:Male; D063766:Pediatric Obesity / Q000235:genetics / Q000628:therapy*; D012307:Risk Factors; D016896:Treatment Outcome; D015431:Weight Loss