title: Adult mesenchymal stem cells and women's health.
abstract: Adult mesenchymal stem cells (MSCs) were previously described as multipotent cells that could differentiate into bone, cartilage, muscle, and other mesenchymal tissues. New information suggests that MSCs can be found in every tissue of the body because they function as perivascular cells--pericytes--found outside all blood vessels. When these vessels break or are inflamed, pericytes are detached and form MSCs, which are activated by their local microenvironment of injury. Such MSCs function to secrete powerful immune-modulatory and regenerative agents; more than 450 clinical trials are now ongoing, covering a huge spectrum of clinical conditions. How such activated MSCs affect menstrual cycle, menopause, or osteotrophic cancers has only recently been studied. This article outlines these issues and challenges the scientific and medical community to use this newfound knowledge to uncover new clinical logics and medial solutions for women.
authors.affiliation: From the Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH.
authors.forename: Arnold I
authors.initials: AI
authors.lastname: Caplan
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008593:Menopause; D008598:Menstruation; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D020286:Pericytes / Q000502:physiology; D016387:Women's Health