title: A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis. Diagnostic and therapeutic features.
abstract: Liposarcoma is one of the more common types of soft tissue sarcomas, presenting with a wide spectrum of clinical behaviour. It is subdivided into five distinct histologic subtypes: well-differentiated, mixoid, pleomorphic, dedifferentiated and mixed-type. Well-differentiated liposarcoma accounts for about 40% to 45% of all liposarcomas therefore representing the larger subgroup of adipocytic malignancies. Well-differentiated spindle cell liposarcoma is an extremely rare subtype of well-differentiated liposarcoma/atypical lipomatous tumor which is different from the other subtypes clinicopathologically, genetically and prognostically. The most common frequent locations of lipomatous tumours are: limbs, groin, scrotum, abdominal wall and retroperitoneal area. MRI examination is a highly reliable method in the diagnosis of these neoplasms. Surgical management includes wide resection of the tumour with or without additional postoperative radiotherapy and/or chemotherapy. We describe a case of 68-year old patient with large well-differentiated spindle cell liposarcoma of the left thigh. We are discussing the clinical findings, diagnosis and therapeutic approach. In these cases, a preoperative disease classification discriminating the tumour nature is closely linked to the correct surgical management of patients.
authors.forename: Daniele
authors.initials: D
authors.lastname: Pironi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vendettuoli
authors.forename: Chiara
authors.initials: C
authors.lastname: Tesori
authors.forename: Bruno
authors.initials: B
authors.lastname: Salvati
authors.forename: Stefano
authors.initials: S
authors.lastname: Pontone
authors.forename: Elena
authors.initials: E
authors.lastname: Pietraforte
authors.forename: Angelo
authors.initials: A
authors.lastname: Filippini
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis; D013848:Thigh / Q000473:pathology; D016896:Treatment Outcome