title: Comparison of the Sofia and Veritor direct antigen detection assay systems for identification of influenza viruses from patient nasopharyngeal specimens.
abstract: Influenza antigen detection assays (Sofia fluorescent immunoassay [FIA] and Veritor) yield objective results, which are potentially useful for point-of-care testing. The assays were evaluated with reverse transcriptase PCR (RT-PCR) using 411 nasopharyngeal swab specimens. Sensitivity and specificity values (percentages) of 79.0/99.0 and 64.0/99.4 for influenza A and 92.9/96.7 and 78.6/98.7 for influenza B were obtained for the Sofia and Veritor assays, respectively.
authors.affiliation: Virology Laboratory, Department of Pathology, Nassau University Medical Center, East Meadow, New York, USA leonardi@numc.edu.
authors.forename: G P
authors.initials: GP
authors.lastname: Leonardi
authors.affiliation: Virology Laboratory, Department of Pathology, Nassau University Medical Center, East Meadow, New York, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Wilson
authors.affiliation: Virology Laboratory, Department of Pathology, Nassau University Medical Center, East Meadow, New York, USA.
authors.forename: I
authors.initials: I
authors.lastname: Mitrache
authors.affiliation: Virology Laboratory, Department of Pathology, Nassau University Medical Center, East Meadow, New York, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Zuretti
mesh_terms: D000956:Antigens, Viral / Q000302:isolation & purification*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D009980:Influenza A virus / Q000302:isolation & purification*; D009981:Influenza B virus / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology*; D009305:Nasopharynx / Q000821:virology*; D019095:Point-of-Care Systems; D011933:Reagent Kits, Diagnostic / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D000956:Antigens, Viral; D011933:Reagent Kits, Diagnostic