title: Spatiotemporal regulation of the anaphase-promoting complex in mitosis.
abstract: The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiquitylation and proteasome-mediated degradation. The APC/C (anaphase-promoting complex; also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of the mitotic cell cycle, particularly at the onset of anaphase and during mitotic exit. Co-activator proteins, inhibitor proteins, protein kinases and phosphatases interact with the APC/C to temporally and spatially control its activity and thus ensure accurate timing of mitotic events.
authors.affiliation: Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Sushama
authors.initials: S
authors.lastname: Sivakumar
authors.affiliation: Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Gorbsky
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D064173:Anaphase-Promoting Complex-Cyclosome