title: A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia.
abstract: Hippocampal pathology has been considered to underlie clinical, functional and cognitive impairments in schizophrenia. While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the hippocampus during the early phases of schizophrenia (SCZ), very little is known about whether functional connectivity (FC) between the hippocampus and other brain regions also exhibit progressive changes. In this study, resting state functional MRI (fMRI) was used to examine changes in hippocampal connectivity at baseline and follow-up scans comparing 68 patients with first episode SCZ and 62 matched controls. At baseline and follow-up, in the bilateral hippocampal network, SCZ mainly showed decreased FC with bilateral cerebellum posterior lobe, frontal gyrus temporal gyrus, precuneus, and cingulate cortex compared to controls. Furthermore, in the bilateral hippocampus, there was a significant interaction effect of group and time for FC with cerebellum posterior lobe, temporal gyrus, frontal gyrus, and posterior cingulate cortex. Interestingly, longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus negatively correlated with positive symptom scores in SCZ. These results provide novel evidence for the progressive changes of FC between hippocampus and other brain regions in SCZ. It further suggests that longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus can contribute to the formation and emergence of positive symptom of SCZ.
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Hui-Feng
authors.initials: HF
authors.lastname: Duan
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China. Electronic address: cco91@163.com.
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Gan
authors.affiliation: Center for Medical Imaging, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Zheng-Xiang
authors.initials: ZX
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Cun-You
authors.initials: CY
authors.lastname: Gao
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Zhen-Juan
authors.initials: ZJ
authors.lastname: Shi
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Xi-Quan
authors.initials: XQ
authors.lastname: Zhu
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
authors.forename: Lan-Min
authors.initials: LM
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001931:Brain Mapping; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012146:Rest; D012559:Schizophrenia / Q000503:physiopathology*
keywords: First-episode schizophrenia; Functional connectivity; Hippocampus; Magnetic resonance imaging; Positive symptom