title: Lenalidomide induces degradation of IKZF1 and IKZF3.
abstract: Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos).
authors.affiliation: Brigham and Women's Hospital ; Boston, MA USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Krönke
authors.affiliation: Brigham and Women's Hospital ; Boston, MA USA.
authors.forename: Slater N
authors.initials: SN
authors.lastname: Hurst
authors.affiliation: Brigham and Women's Hospital ; Boston, MA USA.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Ebert
keywords: lenalidomide; pomalidomide; thalidomide; ubiquitin