title: Parathyroid hormone-related protein-induced hypercalcemia due to osteosarcoma in a cat.
abstract: A 15-year-old castrated male mixed-breed cat was presented with a history of sarcoma of the distal right hind limb. Biochemical analysis revealed increased concentrations of blood urea, creatinine, total calcium, ionized calcium, and parathyroid hormone-related protein (PTHrP). The mass was removed surgically by amputation of the hind limb. Osteosarcoma was diagnosed based on histopathologic examination. All abnormal serum analyte concentrations improved immediately after surgery, including azotemia, total calcium, ionized calcium, and PTHrP. The biochemical results were attributed to osteosarcoma causing PTHrP-induced hypercalcemia.
authors.affiliation: Yuki Animal Hospital, Aichi, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yuki
authors.forename: Makiko
authors.initials: M
authors.lastname: Nitta
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Omachi
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D001859:Bone Neoplasms / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D002118:Calcium / Q000097:blood*; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D006934:Hypercalcemia / Q000209:etiology / Q000662:veterinary*; D008297:Male; D012516:Osteosarcoma / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*
chemical_list: D044162:Parathyroid Hormone-Related Protein; D002118:Calcium
keywords: Endocrine; HHM; feline; malignant mesenchymal tumor; paraneoplastic syndrome