title: Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.
abstract: Phosphine metal complexes have been recently evaluated in the field of cancer therapy. In this research, the cytotoxic effects of some metal phosphines {[PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3)} on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test. C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies. The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested. The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.
authors.affiliation: Department of Chemistry, Science, and Letters Faculty, Osmaniye Korkut Ata University, Fakıuşağı, 80000 Osmaniye, Turkey.
authors.forename: Burcu
authors.identifier: 0000-0001-5179-0522
authors.initials: B
authors.lastname: Saygıdeğer Demir
authors.affiliation: Department of Chemistry and Chemical Technology, University of Bayburt, 69000 Bayburt, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Keleş
authors.affiliation: Science Institute, Kanuni University, 01170 Adana, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Serindağ