title: Evaluation of bone formation after grafting with deproteinized bovine bone and mineralized allogenic bone.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the ability of new bone formation of deproteinized bovine bone (Bio-Oss) and mineralized allogenic bone (Tutoplast).
  
  
  METHODS
  Sixty rats were divided into control and experimental groups (groups 1 and 2): control group, unfilled control; group 1, Bio-Oss; group 2, Tutoplast, respectively. The animals were killed after 6 and 12 weeks, and newly formed bone was analyzed histomorphometrically.
  
  
  RESULTS
  In the control group, some new bone formed in the rim of the defect area. In the group 1, newly formed bone was thinner than the adjacent normal bone, and Bio-Oss particles were observed. In the group 2, showed a pattern of gradual fusion with adjacent bone, as well as particles in some areas, similar to the Bio-Oss-treated group. In the 12-week groups, the amount of new bone formation was significantly higher in the experimental groups than in the control group, and it was significantly higher in group 2 than in group 1.
  
  
  CONCLUSIONS
  Although Tutoplast and Bio-Oss graft materials seem to be useful for bone grafts, Tutoplast showed more active new bone formation than Bio-Oss.
authors.affiliation: *Graduate Student, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea. †Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea. ‡Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea. §Assistant Professor, Department of Oral Biochemistry and Oral Biology Research Institute, School of Dentistry, Chosun University, Gwangju, Korea. ‖Professor, Department of Pathology, School of Medicine, Chosun University, Gwangju, Korea. ¶Assistant Professor, Department of Dental Hygiene, Kangwon National University, Samcheok, Korea.
authors.forename: Kyung-Nam
authors.initials: KN
authors.lastname: Moon
authors.forename: Su-Gwan
authors.initials: SG
authors.lastname: Kim
authors.forename: Ji-Su
authors.initials: JS
authors.lastname: Oh
authors.forename: Chun-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Sung-Chul
authors.initials: SC
authors.lastname: Lim
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Jeong
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D008297:Male; D008903:Minerals; D010012:Osteogenesis / Q000502:physiology; D011138:Polytetrafluoroethylene; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; C000597419:Tutoplast; D011138:Polytetrafluoroethylene