title: Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report.
abstract: BACKGROUND
  Condyloma acuminatum are caused by human papillomavirus. Giant condyloma acuminatum is a locally invasive, destructive, and large sized mass. Risk factors for the development of giant condyloma acuminatum include an immunodeficient state, such as human immunodeficiency virus infection, post-organ transplantation, or post-allogeneic bone marrow transplantation. However, reports of giant condyloma after bone marrow transplantation are extremely rare (0.3 to 1.3%). The standard treatment for giant condyloma acuminatum is recommended as wide surgical resection due to its high rate of success and low rate of recurrence.
  
  
  METHODS
  A 31-year-old Korean man presented to our hospital with anal discomfort for more than one month due to a protruding mass. He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation. Gross findings revealed a large perianal cauliflower-like mass over 7cm in size with invasion of the anal orifice. He was diagnosed with giant anal condyloma occurring after an allogeneic bone marrow transplantation. However, we achieved successful treatment using a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.
  
  
  CONCLUSIONS
  We report an extremely rare case of giant condyloma acuminatum of anus due to human papillomavirus type six in a patient with acute lymphoblastic leukemia following an allogeneic bone marrow transplantation. The tumor was successfully treated with a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Hyun
authors.forename: Gee-Bum
authors.initials: GB
authors.lastname: Kim
authors.forename: Byung-Seok
authors.initials: BS
authors.lastname: Choi
authors.forename: Min-Sung
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Hemato-oncology, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Republic of Korea. sgpark@chosun.ac.kr.
authors.forename: Sang-Gon
authors.initials: SG
authors.lastname: Park
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D001005:Anus Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001761:Bleomycin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D017679:Cryotherapy / Q000379:methods; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D011033:Podophyllin / Q000008:administration & dosage; D014184:Transplantation, Homologous / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D001761:Bleomycin; D011033:Podophyllin