title: Advances in the understanding of complement mediated glomerular disease: implications for recurrence in the transplant setting.
abstract: Recent advances in the understanding of the role of complement in glomerular disease allow for more accurate assessment of the risk of disease recurrence after transplantation, and inform the development of targeted treatment strategies to overcome specific defects in the alternate pathway of the complement system. These advances along with remaining knowledge deficits are reviewed with specific relevance to membranoproliferative glomerulonephritis (MPGN) and C3 glomerulopathy, a heterogenous group of diseases with a high rate of recurrence leading to allograft failure. Recommendations to establish an accurate diagnosis and inform therapeutic decision making in transplant candidates with a histologic diagnosis of MPGN are provided.
authors.affiliation: Division of Nephrology, University of British Columbia, Vancouver, Canada; BC Provincial Renal Agency, Vancouver, Canada; Centre for Health Evaluation and Outcomes Sciences, University of British Columbia, Vancouver, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Barbour
authors.forename: J S
authors.initials: JS
authors.lastname: Gill
mesh_terms: D003165:Complement System Proteins / Q000502:physiology*; D015432:Glomerulonephritis, Membranoproliferative / Q000503:physiopathology*; D006801:Humans; D016030:Kidney Transplantation; D012008:Recurrence; D012307:Risk Factors
chemical_list: D003165:Complement System Proteins
keywords: biopsy; clinical research/practice; complement biology; glomerular biology and disease; immunobiology; kidney transplantation/nephrology; pathology/histopathology; recurrent disease