title: Cell immobilization for microbial production of 1,3-propanediol.
abstract: Cell and enzyme immobilization are often used for industrial production of high-value products. In recent years, immobilization techniques have been applied to the production of value-added chemicals such as 1,3-Propanediol (1,3-PDO). Biotechnological fermentation is an attractive alternative to current 1,3-PDO production methods, which are primarily thermochemical processes, as it generates high volumetric yields of 1,3-PDO, is a much less energy intensive process, and generates lower amounts of environmental organic pollutants. Although several approaches including: batch, fed-batch, continuous-feed and two-step continuous-feed were tested in suspended systems, it has been well demonstrated that cell immobilization techniques can significantly enhance 1,3-PDO production and allow robust continuous production in smaller bioreactors. This review covers various immobilization methods and their application for 1,3-PDO production.
authors.affiliation: a Department of Bioengineering, Faculty of Engineering , Ege University , Bornova , Izmir , Turkey and.
authors.forename: Mine
authors.initials: M
authors.lastname: Gungormusler-Yilmaz
authors.affiliation: b Department of Biosystems Engineering , University of Manitoba , Winnipeg , MB , Canada.
authors.forename: Nazim
authors.initials: N
authors.lastname: Cicek
authors.affiliation: b Department of Biosystems Engineering , University of Manitoba , Winnipeg , MB , Canada.
authors.forename: David B
authors.initials: DB
authors.lastname: Levin
authors.affiliation: a Department of Bioengineering, Faculty of Engineering , Ege University , Bornova , Izmir , Turkey and.
authors.forename: Nuri
authors.initials: N
authors.lastname: Azbar
mesh_terms: D056804:Biofuels; D019149:Bioreactors; D018914:Cells, Immobilized; D005285:Fermentation; D005990:Glycerol; D007218:Industrial Microbiology; D011409:Propylene Glycols / Q000378:metabolism*
chemical_list: D056804:Biofuels; D011409:Propylene Glycols; C041787:1,3-propanediol; D005990:Glycerol
keywords: Attachment; biodiesel; biotechnology; entrapment; fermentation; glycerol