title: Cancer therapy-induced cardiotoxicity: role of ultrasound deformation imaging as an aid to early diagnosis.
abstract: In the last decade, ultrasound deformation imaging, based on both Doppler and speckle tracking echocardiography techniques, has emerged as a more sensitive tool to identify subtle and subclinical left ventricular systolic dysfunction in several clinical settings compared with ejection fraction. In this article, we review the evidence relative to the application of ultrasound deformation imaging to the oncologic field for detection of left ventricular systolic dysfunction induced by cardiotoxic treatments with the aim of verifying whether this approach may actually help in early diagnosis of chemotherapy-induced cardiotoxicity.
authors.affiliation: Department of Cardiology, University Hospital of Ferrara, Ferrara, Italy. Electronic address: donatomele@libero.it.
authors.forename: Donato
authors.initials: D
authors.lastname: Mele
authors.affiliation: Department of Medical Sciences, University Hospital of Ferrara, Ferrara, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rizzo
authors.affiliation: Department of Cardiology, University Hospital of Ferrara, Ferrara, Italy.
authors.forename: Alberto V
authors.initials: AV
authors.lastname: Pollina
authors.affiliation: Department of Cardiology, University Hospital of Ferrara, Ferrara, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fiorencis
authors.affiliation: Department of Cardiology, University Hospital of Ferrara, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
mesh_terms: D000970:Antineoplastic Agents / Q000633:toxicity*; D066126:Cardiotoxicity / Q000000981:diagnostic imaging*; D055088:Early Detection of Cancer; D042241:Early Diagnosis; D004452:Echocardiography / Q000379:methods*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Anthracyclines; Cardiotoxicity; Chemotherapy; Speckle tracking echocardiography; Trastuzumab