title: In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography.
abstract: Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.
authors.affiliation: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United StatesbThe State University of New York, University at Buffalo, Department of Biomedical Engineering, Buffalo, New York.
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.affiliation: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States.
authors.forename: Terence T W
authors.initials: TT
authors.lastname: Wong
authors.affiliation: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States.
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D059906:Neuroimaging / Q000295:instrumentation / Q000379:methods*; D055100:Optical Fibers; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D014054:Tomography / Q000379:methods*