title: The role of anti-tubercular therapy in patients with presumed ocular tuberculosis.
abstract: OBJECTIVE
  To analyze the factors affecting the treatment outcome in patients with presumed ocular tuberculosis on anti-tubercular therapy (ATT).
  
  
  METHODS
  Retrospective chart review of patients with presumed ocular tuberculosis seen at a tertiary referral eye care center in the United Kingdom. Failure was defined as recurrence of inflammation within 6 months of completion of ATT.
  
  
  RESULTS
  There were a total of 175 patients with presumed ocular tuberculosis who had ATT. Patients with intermediate uveitis or panuveitis and those on immunosuppressive therapy had higher odds of treatment failure (p < 0.05) while those with more than 9 months of ATT (77, 79.38%) had less likelihood of failure.
  
  
  CONCLUSIONS
  We present the largest case series of patients with presumed ocular tuberculosis in a low endemic area treated with ATT. Longer duration of treatment resulted in reduced risk of recurrence of inflammation, whereas immunosuppression adversely affected the final treatment outcome.
authors.affiliation: Moorfields Eye Hospital, NHS Foundation Trust , London , UK .
authors.forename: Rupesh
authors.initials: R
authors.lastname: Agrawal
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Gupta
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Gonzalez-Lopez
authors.forename: Farzana
authors.initials: F
authors.lastname: Rahman
authors.forename: Sumita
authors.initials: S
authors.lastname: Phatak
authors.forename: Ioanna
authors.initials: I
authors.lastname: Triantafyllopoulou
authors.forename: Peter K F
authors.initials: PK
authors.lastname: Addison
authors.forename: Mark
authors.initials: M
authors.lastname: Westcott
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Pavesio
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014374:Tuberculin Test; D014392:Tuberculosis, Ocular / Q000175:diagnosis / Q000188:drug therapy*; D006113:United Kingdom; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: Anti-tubercular therapy (ATT); QuantiFERON gold in tube (QFT); duration of ATT; immunosuppression; intermediate uveitis; presumed ocular tuberculosis