title: Recent advances in image-guided targeted prostate biopsy.
abstract: Prostate cancer is a common malignancy in the United States that results in over 30,000 deaths per year. The current state of prostate cancer diagnosis, based on PSA screening and sextant biopsy, has been criticized for both overdiagnosis of low-grade tumors and underdiagnosis of clinically significant prostate cancers (Gleason score ≥7). Recently, image guidance has been added to perform targeted biopsies of lesions detected on multi-parametric magnetic resonance imaging (mpMRI) scans. These methods have improved the ability to detect clinically significant cancer, while reducing the diagnosis of low-grade tumors. Several approaches have been explored to improve the accuracy of image-guided targeted prostate biopsy, including in-bore MRI-guided, cognitive fusion, and MRI/transrectal ultrasound fusion-guided biopsy. This review will examine recent advances in these image-guided targeted prostate biopsy techniques.
authors.affiliation: Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Brown
authors.forename: Osama
authors.initials: O
authors.lastname: Elbuluk
authors.forename: Francesca
authors.initials: F
authors.lastname: Mertan
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sankineni
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Margolis
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: Wood
authors.forename: Peter A
authors.initials: PA
authors.lastname: Pinto
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
mesh_terms: D006801:Humans; D061705:Image-Guided Biopsy; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D018084:Ultrasonography, Interventional