title: Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation.
abstract: Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment.
authors.affiliation: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.
authors.forename: Genovefa A
authors.initials: GA
authors.lastname: Papanicolaou
authors.affiliation: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Yeon Joo
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: James W
authors.initials: JW
authors.lastname: Young
authors.affiliation: Department of Pathology, Weill Cornell Medical College, New York, NY.
authors.forename: Surya V
authors.initials: SV
authors.lastname: Seshan
authors.affiliation: Saint Francis Hospital and Medical Center and University of Connecticut School of Medicine, Hartford, CT.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Boruchov
authors.affiliation: Chimerix, Inc, Durham, NC.
authors.forename: Gregory
authors.initials: G
authors.lastname: Chittick
authors.affiliation: Chimerix, Inc, Durham, NC.
authors.forename: Herve
authors.initials: H
authors.lastname: Momméja-Marin
authors.affiliation: Department of Medicine, Weill Cornell Medical College, New York, NY; Renal Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: glezermi@mskcc.org.
authors.forename: Ilya G
authors.initials: IG
authors.lastname: Glezerman
mesh_terms: D001739:BK Virus; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D011120:Polyomavirus; D027601:Polyomavirus Infections / Q000188:drug therapy*; D014412:Tumor Virus Infections / Q000188:drug therapy*; D014766:Viremia / Q000188:drug therapy
chemical_list: D063065:Organophosphonates; C525733:brincidofovir; D003596:Cytosine
keywords: BK viremia; BK virus; Polyomavirus-associated nephropathy (PVAN); brincidofovir; hematopoietic stem cell (HSC) transplantation; kidney failure