title: Effect of nepafenac eye drops on pain associated with pterygium surgery.
abstract: OBJECTIVE
  To assess the effects of nepafenac ophthalmic suspension 0.1% for control of pain in patients undergoing pterygium surgery.
  
  
  METHODS
  This randomized, double-masked placebo-controlled study included 62 adults undergoing pterygium surgery. Patients were randomly assigned to receive nepafenac ophthalmic suspension 0.1% or balanced salt solution placebo. They were asked to assess the level of pain using an 11-point numeric rating scale at 6, 12, 24, 48, and 72 hr after surgery. Patients also were evaluated daily for the progression of corneal epithelial healing until complete closure was observed.
  
  
  RESULTS
  Except at 72 hr after surgery, the patients reported significantly less pain in eyes receiving nepafenac than in eyes receiving placebo. There was no statistical difference between the two groups in corneal epithelial healing.
  
  
  CONCLUSIONS
  Treatment with nepafenac ophthalmic suspension 0.1% significantly reduced postoperative pain compared with placebo after pterygium surgery.
authors.affiliation: Department of Ophthalmology (M.O., Y.S., S.G., R.S., A.B.), Konya Training and Research Hospital, Konya, Turkey; Department of Ophthalmology (H.I.Y.), Private Konya Eye Hospital, Konya, Turkey; and Department of Public Health (L.S.D.), Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Ozcimen
authors.forename: Yasar
authors.initials: Y
authors.lastname: Sakarya
authors.forename: Sertan
authors.initials: S
authors.lastname: Goktas
authors.forename: Rabia
authors.initials: R
authors.lastname: Sakarya
authors.forename: Halil I
authors.initials: HI
authors.lastname: Yener
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Bukus
authors.forename: Lutfi S
authors.initials: LS
authors.lastname: Demir
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D044482:Benzeneacetamides / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000188:drug therapy*; D010648:Phenylacetates / Q000008:administration & dosage*; D011625:Pterygium / Q000601:surgery*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D009883:Ophthalmic Solutions; D010648:Phenylacetates; C414203:nepafenac