title: Mortality among chemical plant workers exposed to acrylonitrile: 2011 follow-up.
abstract: OBJECTIVE
  To update a cohort study of chemical workers and reevaluate lung cancer mortality in relation to acrylonitrile (AN) exposure.
  
  
  METHODS
  Subjects were 2096 workers employed during 1955 to 2011. We identified 474 deaths through 2011, and quantitatively estimated worker exposures to AN. Analyses included national and county-based standardized mortality ratios and relative risk regression of internal cohort rates.
  
  
  RESULTS
  We found no statistically significant excess mortality risks associated with Lima employment for any cause of death category, including lung cancer and other cancer sites implicated in previous studies.
  
  
  CONCLUSIONS
  This update provides no evidence that exposure to AN at levels experienced by Lima workers is associated with an increased risk of lung cancer mortality, as suggested in original study. Earlier reported bladder cancer risks decreased to a much lower, not statistically significant level.
authors.affiliation: From the Center for Occupational Biostatistics and Epidemiology (Dr Marsh and Ms Zimmerman), Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pa.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Marsh
authors.forename: Sarah D
authors.initials: SD
authors.lastname: Zimmerman
mesh_terms: D000181:Acrylonitrile / Q000032:analysis* / Q000633:toxicity; D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity; D002273:Carcinogens / Q000032:analysis* / Q000633:toxicity; D002423:Cause of Death; D016543:Central Nervous System Neoplasms / Q000401:mortality; D002617:Chemical Industry / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000032:analysis*; D009820:Ohio / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000401:mortality; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000401:mortality
chemical_list: D000395:Air Pollutants, Occupational; D002273:Carcinogens; D000181:Acrylonitrile