title: [Establishment of mouse endometrial injury model by electrocoagulation].
abstract: OBJECTIVE
  To establish the murine model of moderate endometrial injury.
  
  
  METHODS
  Electrocoagulation was applied to induce endometrial injury of ICR mice with 0.5 watts power while contralateral uterine cavity acted as control without electrocoagulation. The endometrial histomorphology was observed in 7 days later by microscopy and fetal number of each lateral uterus assessed at 17.5 days after pregnancy.
  
  
  RESULTS
  At 7 days post-electrocoagulation, the average endometrial thickness of operating side was significantly thinner than that of control side (1.14 ± 0.08 vs 1.88 ± 0.15 mm, P < 0.05). The density of endometrial glands of operating side was significantly lower than that of control side (20 ± 2 vs 32 ± 3 per 100x field, P < 0.05). After pregnancy, the average number of embryos at operating side decreased by 63.1% compared with control (3 ± 2 vs 8 ± 2, P < 0.01).
  
  
  CONCLUSIONS
  The established model of endometrial electrocoagulation injury shows morphologic changes and decreased fertile ability. It has potential uses for animal studies of endometrial injury treatment.
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Yinshen
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Jieyu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics & Gynecology, Sir Run Run Shaw Hospital, Hangzhou 310016, China. Email: zhangsongying@126.com.
authors.forename: Songying
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004564:Electrocoagulation; D004717:Endometrium; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy