title: Seizing the clinical presentation in adult onset Still's disease. An extensive literature review.
abstract: Adult onset Still's disease is an inflammatory disorder with a wide clinical presentation ranging from arthralgia and arthritis to rash and high-grade fever. Etiology of this rare disorder remains a mystery. We present two cases at the extreme ends of clinical presentation diagnosed with AOSD along with literature review for the same. Case one was self limiting, requiring only NSAIDS as treatment. The other was an unusual central nervous system manifestation of repeated seizures that were only responsive to pulse dose of methylprednisolone. Both met Yamaguchi criteria for adult onset Still's disease.
authors.affiliation: Department of Rheumatology, Mayo Clinic, Jacksonville, FL, United States. Electronic address: Narula.neha@mayo.edu.
authors.forename: Neha
authors.initials: N
authors.lastname: Narula
authors.affiliation: Pulmonary Critical Care, RCCSMA, Jacksonville, FL, United States.
authors.forename: Tathagat
authors.initials: T
authors.lastname: Narula
authors.affiliation: Department of Rheumatology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Andy
authors.initials: A
authors.lastname: Abril
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008775:Methylprednisolone
keywords: Adult onset still's disease; Anakinra; Hyperferritinemia syndrome; Seizures