title: New-generation filler based on cross-linked carboxymethylcellulose: study of 350 patients with 3-year follow-up.
abstract: OBJECTIVE
  In recent years there has been a growing interest in nonsurgical procedures for facial rejuvenation. Hyaluronic acid is currently the most widely used dermal filler for the treatment of facial wrinkles. However, new products with interesting features are being introduced into the market. Cross-linked carboxymethylcellulose is one of these and represents a new alternative for the correction of wrinkles and facial defects.
  
  
  METHODS
  The retrospective, multicenter, open-label study on nasolabial folds reported here was carried out between January 2010 and April 2014 on 350 subjects between 22 and 67 years of age for a 36-month follow-up period in order to consistently and extensively assess the safety and performance of this treatment.
  
  
  RESULTS
  The study revealed effective and durable correction of nasolabial wrinkles for periods of 9-12 months. Product reapplication over a 36-month period did not lead to an increase in adverse effects, which always remained rare and of little clinical significance, usually consisting of bruising and redness.
  
  
  CONCLUSIONS
  Cross-linked carboxymethyl cellulose has been shown to be a safe and effective alternative to the resorbable products currently on the market.
authors.affiliation: Department of Plastic Surgery, Salvator Mundi International Hospital, Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Leonardis
authors.affiliation: Department of Aesthetic Medicine, Fisiobios Clinic, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Palange
mesh_terms: D000328:Adult; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage* / Q000009:adverse effects; D003357:Cosmetic Techniques; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D060052:Nasolabial Fold / Q000473:pathology; D017060:Patient Satisfaction; D012060:Rejuvenation; D012189:Retrospective Studies; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D055675:Viscosupplements / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D055675:Viscosupplements; D002266:Carboxymethylcellulose Sodium
keywords: dermal fillers; facial aging; hyaluronic acids; nasolabial fold; patient satisfaction