title: Anticipatory role of high density lipoprotein and endothelial dysfunction: an overview.
abstract: High Density Lipoprotein (HDL) has been witnessed to possess a range of different functions that contribute to its atheroprotective effects. These functions are: the promotion of macrophage cholesterol efflux, reverse cholesterol transport, anti-inflammatory, anti-thrombotic, anti-apoptotic, pro-fibrinolytic and anti-oxidative functions. Paraoxonase 1 (PON1) is an HDL associated enzyme esterase/homocysteinethiolactonase that contributes to the anti-oxidant and anti-atherosclerotic capabilities of HDL. PON1 is directly involved in the etiopathogenesis of atherosclerosis through the modulation of nitric oxide (NO) bioavailability. The aim of this review is to summarize the role of HDL on endothelial homeostasis, and also to describe the recently characterized molecular pathways involved.
authors.affiliation: Laboratory of Atatürk Hospital, Antalya/Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya/Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yılmaz
authors.affiliation: Laboratory of Batman Maternity and Children's Hospital, Batman/Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydin
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya/Turkey.
authors.forename: Hamit Y
authors.initials: HY
authors.lastname: Ellidağ
keywords: Endothelial function; high-density lipoprotein; homocysteine; nitric oxide; oxLDL; oxidative stress; paraoxonase.