title: Association between renal function, erectile function and coronary artery disease: detection with coronary angiography.
abstract: OBJECTIVE
  Many patients admitted for acute myocardial infarction (AMI) have chronic renal insufficiency and erectile dysfunction (ED). This study aimed to evaluate the relationship between ED and the glomerular filtration rate (GFR) in patients with coronary artery disease.
  
  
  METHODS
  We studied 183 patients undergoing coronary angiography owing to AMI. The GFR was calculated and the International Index of Erectile Function-5 (IIEF-5) was used to evaluate ED. The relations between erectile function, GFR, and the number of occluded coronary arteries were evaluated.
  
  
  RESULTS
  Of 183 patients with a mean age of 55.2±11.16 years who underwent coronary angiography owing to AMI, 100 (54.64%) had ED. The ED rate was 45.36% (44/97) in patients with single-vessel disease, 64.5% (31/48) in patients with two-vessel disease, and 65.7% (25/38) in patients with three-vessel disease. The ED rate in patients with single-vessel disease was significantly lower than in the other groups (p<0.001). The mean IIEF scores were 24.2±4.3, 20.4±4.9, and 20.5±4.2 in the three groups, respectively (p<0.001). Mean GFRs were similar in patients with single-vessel disease, two-vessel disease, and three-vessel disease (128.2±46.8, 130.8±70.9, and 110.8±44.6, respectively, p=0.171). The GFR was significantly lower in the presence of ED only for single-vessel disease (p=0.001).
  
  
  CONCLUSIONS
  This study confirmed that the presence and severity of ED are linked to the number of occluded vessels as documented by coronary angiography. The presence of ED and reduced GFR are associated with single-vessel coronary artery disease. This relationship can be used to predict the likelihood of coronary artery disease.
authors.affiliation: Department of Urology, Kastamonu State Hospital, Kastamonu, Turkey.
authors.forename: Lutfi
authors.initials: L
authors.lastname: Canat
authors.affiliation: Department of Endocrinology, Istanbul Şişli Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: Masum
authors.initials: M
authors.lastname: Canat
authors.affiliation: Department of Urology, Hayri Sivrikaya Private Hospital, Duzce, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Guner
authors.affiliation: Department of Urology, Istanbul Goztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Gurbuz
authors.affiliation: Department of Urology, Istanbul Goztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Turhan
authors.initials: T
authors.lastname: Caşkurlu
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D054059:Coronary Occlusion / Q000000981:diagnostic imaging*; D007172:Erectile Dysfunction / Q000453:epidemiology*; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Coronary artery disease; Erectile dysfunction; Glomerular filtration rate