title: One step creation of multifunctional 3D architectured hydrogels inducing bone regeneration.
abstract: Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.
authors.affiliation: Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513, Teltow, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz 1, 13533 Berlin and Kantstr. 55, 14513, Teltow, Germany.
authors.forename: Axel T
authors.initials: AT
authors.lastname: Neffe
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Pierce
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tronci
authors.forename: Nan
authors.initials: N
authors.lastname: Ma
authors.forename: Erik
authors.initials: E
authors.lastname: Pittermann
authors.forename: Tim
authors.initials: T
authors.lastname: Gebauer
authors.forename: Oliver
authors.initials: O
authors.lastname: Frank
authors.forename: Michael
authors.initials: M
authors.lastname: Schossig
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
authors.forename: Bettina M
authors.initials: BM
authors.lastname: Willie
authors.forename: Michèle
authors.initials: M
authors.lastname: Forner
authors.forename: Agnes
authors.initials: A
authors.lastname: Ellinghaus
authors.forename: Jasmin
authors.initials: J
authors.lastname: Lienau
authors.forename: Georg N
authors.initials: GN
authors.lastname: Duda
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology; D002146:Bony Callus / Q000503:physiopathology; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured; D004548:Elasticity; D005260:Female; D005269:Femur / Q000293:injuries; D005347:Fibroblasts / Q000502:physiology; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000502:physiology; D010812:Physical Stimulation / Q000295:instrumentation / Q000379:methods; D016062:Porosity; D017207:Rats, Sprague-Dawley
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D005780:Gelatin
keywords: biomaterial-induced regeneration; in vivo studies; mechanical properties; multifunctionality; structured hydrogels