title: Economic burden of chemotherapy-induced febrile neutropenia in patients with lymphoma: a systematic review.
abstract: The primary objective of this review was to identify the cost components that were most frequently associated with the economic burden of febrile neutropenia (FN) among patients with lymphoma. The secondary objective was to identify any parameter associated with higher FN cost. Ten cost of illness (COI) studies were identified. General characteristics on study design, country, perspective, and patient population were extracted and systematically reported. It was observed that majority (70%) of the studies employed the perspective of healthcare provider. 20% of the studies considered long-term costs. Estimated costs were adjusted to 2013 US dollars and ranged from US$5819 to US$34,756. The cost components that were most frequently associated with economic burden were ward and medication costs. Inpatient management, male gender, discharged dead, and comorbidity were positively associated with higher FN costs. Future COI studies on FN should focus on the accurate estimation on ward and medication costs.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore; Department of Pharmacy, National Cancer Centre Singapore, Singapore.
authors.forename: Xiao Jun
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
authors.forename: Shaun Eric
authors.initials: SE
authors.lastname: Lopez
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore; Department of Pharmacy, National Cancer Centre Singapore, Singapore. Electronic address: phaac@nus.edu.sg.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000191:economics* / Q000209:etiology*; D017281:Cost of Illness; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000188:drug therapy
keywords: Cost; Economic burden; Febrile neutropenia; Fever; Lymphoma; Neutropenia; Systematic review