title: Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview.
abstract: Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer's disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3000-354, Coimbra, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Carvalho
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3000-354, Coimbra, Portugal.|Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal.
authors.forename: Sónia C
authors.initials: SC
authors.lastname: Correia
authors.affiliation: College of Sciences, The University of Texas at San Antonio, San Antonio, TX, 78249, USA. george.perry@utsa.edu.|Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. george.perry@utsa.edu.
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.affiliation: Division of Neuropathology, University of Maryland, Baltimore, MD, USA.
authors.forename: Rudy J
authors.initials: RJ
authors.lastname: Castellani
authors.affiliation: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3000-354, Coimbra, Portugal. venta@ci.uc.pt.|Faculty of Medicine, Institute of Physiology, University of Coimbra, 3000-354, Coimbra, Portugal. venta@ci.uc.pt.
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000473:pathology / Q000502:physiology*
keywords: Alzheimer’s disease; Brain vasculature; Mitochondria; Oxidative stress