title: [Clinical efficacy of mouse nerve growth factor in treatment of occupational hand-arm vibration disease].
abstract: OBJECTIVE
  To investigate the efficacy of mouse nerve growth factor (mNGF) in treating occupational hand-arm vibration disease (HAVD).
  
  
  METHODS
  Sixty-four patients with HAVD were equally and randomly divided into treatment group and control group. The control group was given Salvia miltiorrhiza Bunge and deproteinized extract of calf blood to improve circulation, and also given methylcobalamin tablets and vitamin B6 for neurotrophic treatment. In addition to the above treatments for the control group, the treatment group was also given 30 µg/d mNGF by intramuscular injection for two courses (4 weeks for each course) with a 15-day interval.
  
  
  RESULTS
  Both the treatment group and the control group showed significant improvements in clinical symptoms and signs (hand numbness and pain, and reduced senses of touch, pain, and vibration), cold water loading test (CWLT), and electroneuromyography (ENMG) after treatments (P < 0.05). And the treatment group had significantly more improvements than the control group (P < 0.05).
  
  
  CONCLUSIONS
  mNGF can significantly improve hand numbness and pain, reduced senses of touch, pain, and vibration, CWLT, and ENMG, so it has better clinical effect and safety in treating HAVD. Early diagnosis and treatment can improve the outcome of patients with HAVD.
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Chunyue
authors.initials: C
authors.lastname: Fan
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lang
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Deng
authors.affiliation: Guangdong Provincial Prevention and Treatment Center for Occupational Diseases Guangzhou 510300, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D053421:Hand-Arm Vibration Syndrome / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D020932:Nerve Growth Factor / Q000494:pharmacology*; D009784:Occupational Diseases; D016896:Treatment Outcome; D014732:Vibration
chemical_list: D020932:Nerve Growth Factor