title: Neonatal status epilepticus: differences between preterm and term newborns.
abstract: BACKGROUND
  Despite the many studies on neonatal seizures, neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition. We report the characteristics of newborns with NSE in order to assess whether they showed homogeneous features or displayed clinical and/or instrumental differences depending on gestational age (GA). Preterm and term neonates were compared and risk factors for adverse outcome evaluated.
  
  
  METHODS
  From 154 newborns with video-EEG confirmed neonatal seizures admitted to the NICU of Parma University Hospital between January 1999 and December 2012, we collected a cohort of 47 newborns (19 preterm, 28 full-term) with NSE. NSE was defined as continuous seizure activity for at least 30 min or recurrent seizures lasting a total of 30 min without definite return to the baseline neurologic condition between seizures. Outcome was assessed at least at one year. We applied the χ(2) test to compare nominal data, and multivariate logistic regression analysis to determine independent risk factors for adverse outcome.
  
  
  RESULTS
  Only Apgar scores and neurologic examination (p ≤ .02) were different between the groups. None of the preterm newborns had a favourable outcome compared to 25% of the full-term ones (p = .032). Moreover, 52.6% of preterm neonates died compared to 17.8% of the full-term newborns (p = .01; OR = 5.11). The only variable related to outcome was Apgar score at 5 min (p = .02).
  
  
  CONCLUSIONS
  Newborns with NSE represented a quite homogeneous group regardless of the GA. Outcome was unfavourable in most of the subjects; however adverse outcome and death were more represented in preterm newborns.
authors.affiliation: Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Italy. Electronic address: elena.pavlidis@studenti.unipr.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Pavlidis
authors.affiliation: Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Spagnoli
authors.affiliation: Psychometrics, Neuroscience Department, University of Parma, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pelosi
authors.affiliation: Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Mazzotta
authors.affiliation: Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pisani
mesh_terms: D001034:Apgar Score; D004569:Electroencephalography; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000401:mortality / Q000503:physiopathology; D007234:Infant, Premature; D008297:Male; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis; D013226:Status Epilepticus / Q000150:complications* / Q000401:mortality / Q000503:physiopathology
keywords: Neonatal seizures; Neonatal status epilepticus; Outcome; Status epilepticus