title: [Therapeutic issues concerning male fertility].
abstract: Men reproductive health has long been ignored although it is responsible for 50% of couple's infertility. However, in recent years, the understanding of endocrine physiology underlying testis development and spermatogenesis has enabled the development of new therapeutic strategies. Some concern the management of male infertility. Others are dealing with finding an effective male contraceptive. In this review, we first present the management of infertility, in patients with congenital hypogonadotropic hypogonadism. We then describe the major improvements for Klinefelter patient's infertility. Finally, we review the different hormonal and non-hormonal methods for male contraception, currently in development. Efficacy and safety of the some non-hormonal methods remain to be demonstrated so far in humans.
authors.affiliation: Unité INSERM 693, 63 rue Gabriel-Péri, 94276 Le Kremlin-Bicêtre cedex, France. Electronic address: valerie.bernard@u-psud.fr.
authors.forename: V
authors.initials: V
authors.lastname: Bernard
authors.affiliation: Service d'endocrinologie et diabétologie pédiatrique, CHU de Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouvattier
authors.affiliation: Service d'endocrinologie et maladies de la reproduction, Hôpital Saint-Antoine, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Christin-Maitre
mesh_terms: D003272:Contraceptive Agents, Male; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006065:Gonadotropins, Pituitary / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000628:therapy; D007031:Hypothalamus / Q000502:physiology; D007248:Infertility, Male / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D007713:Klinefelter Syndrome / Q000150:complications / Q000628:therapy; D007986:Luteinizing Hormone / Q000627:therapeutic use; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis; D013737:Testis / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D003272:Contraceptive Agents, Male; D006065:Gonadotropins, Pituitary; D006728:Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Congenital hypogonadotropic hypogonadism; Contraception masculine; Fertilité masculine; Hypogonadisme hypogonadotrope congénital; Klinefelter syndrome; Male contraception; Male reproduction; Spermatogenesis; Spermatogenèse; Syndrome de Klinefelter