title: A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration.
abstract: Pharmacokinetic properties of isorhamnetin, quercetin, and kaempferol in three different total flavones of Hippophae rhamnoides (TFH) preparations were compared after oral administration to beagle dogs by a UPLC-MS method. The pharmacokinetic results showed that C max of isorhamnetin and quercetin in TFH solid dispersion (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly enhanced than that in TFH preparations (p < 0.05). The AUCs of isorhamnetin and quercetin in TFH-SD were 5.9- and 3.1-fold higher than that of TFH, while the AUCs of isorhamnetin and quercetin in TFH-SE were 3.4- and 2.4-fold higher than that of TFH. These findings suggested that the oral bioavailability of isorhamnetin and quercetin in beagle dogs can be significantly increased in TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to explore the new forms for oral administration TFH and explain their in vivo processes.
authors.affiliation: Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.|Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Jingze
authors.initials: J
authors.lastname: Duan
authors.affiliation: Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.|Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Houjun
authors.initials: H
authors.lastname: Meng
authors.affiliation: Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Wang
authors.affiliation: Global Pharmaceutical Research and Development, Hospira Inc., 1776 North Centennial Drive, Mcpherson, KS, 67460, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.affiliation: Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.|Pharmacy Department, Shanghai TCM-integrated Hospital, Shanghai, 200082, China.
authors.forename: Guowen
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China. rosexie_1996@hotmail.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D004655:Emulsions / Q000493:pharmacokinetics; D047309:Flavones / Q000493:pharmacokinetics*; D031281:Hippophae / Q000737:chemistry*; D044949:Kaempferols / Q000493:pharmacokinetics; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives / Q000493:pharmacokinetics
chemical_list: D004655:Emulsions; D047309:Flavones; D044949:Kaempferols; C047368:3-methylquercetin; C006552:kaempferol; D011794:Quercetin
keywords: Beagle dogs; Pharmacokinetics; Self-emulsifying; Solid dispersion; Total flavones of Hippophae rhamnoides; UPLC–MS