title: The roles of signaling pathways in regulating kidney development.
abstract: The development of mammalian kidney is a complex process. The reciprocal inductive interactions between epithelial cells and metanephric mesenchymal cells determine cell fates including proliferation, growth, apoptosis, and eventually contribute to the formation of an intact kidney. Multiple signaling pathways, including the GDNF/Ret, Wnt and BMP signaling pathways, have been shown to regulate the development of kidney. A myriad of signaling pathways and their cross-talks form a precise spatiotemporal regulatory network, which ensures the kidney to be properly organized. In this review, we summarize the physiological process of kidney development as well as the involved signaling pathways and their interplay.
authors.affiliation: 1.School of Life Sciences, Tsinghua University, Beijing 100089, China.|2.State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Rong-Fei
authors.initials: RF
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Ling-Qiang
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: 1.School of Life Sciences, Tsinghua University, Beijing 100089, China.|2.State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Fu-Chu
authors.initials: FC
authors.lastname: He
authors.affiliation: 1.School of Life Sciences, Tsinghua University, Beijing 100089, China.|2.State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Qiu
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000254:growth & development* / Q000378:metabolism*; D038081:Organogenesis; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011506:Proteins