title: Risk factors associated to diabetes in Mexican population and phenotype of the individuals who will convert to diabetes.
abstract: OBJECTIVE
  To describe risk factors associated to the incidence of type 2 diabetes (T2D) in Mexican population and to define phenotypic (clinical, anthropometric, metabolic) characteristics present in the individual who will convert to diabetes, regardless of time of onset.
  
  
  METHODS
  The Mexico City Diabetes Study began in 1990, with 2 282 participants, and had three subsequent phases: 1994, 1998, and 2008. A systematic evaluation with an oral glucose tolerance test was performed in each phase. For diagnosis of T2D, American Diabetes Association criteria were used.
  
  
  RESULTS
  The population at risk was 1939 individuals. Subjects who were in the converter stage (initially non diabetic that eventually converted to T2D) had, at baseline, higher BMI (30 vs 27), systolic blood pressure (119 vs 116 mmHg), fasting glucose (90 vs 82mg/dl), triglycerides (239 vs 196mg/dl), and cholesterol (192 vs 190mg/dl), compared with subjects who remained non converters (p<0.05).
  
  
  CONCLUSIONS
  The phenotype described represents a potentially identifiable phase and a target for preventive intervention.
authors.affiliation: Unidad de Investigación en Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pública, México, DF, 01120, cliceriogonzalez@hotmail.com.
authors.forename: Clicerio
authors.initials: C
authors.lastname: González-Villalpando
authors.affiliation: Facultad Latinoamericana de Ciencias Sociales, México, Distrito Federal, México.
authors.forename: Claudio Alberto
authors.initials: CA
authors.lastname: Dávila-Cervantes
authors.affiliation: Unidad de Investigación en Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pública, México, DF, 01120, cliceriogonzalez@hotmail.com.
authors.forename: Mireya
authors.initials: M
authors.lastname: Zamora-Macorra
authors.affiliation: Dirección de Estadística, Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública, México.
authors.forename: Belem
authors.initials: B
authors.lastname: Trejo-Valdivia
authors.affiliation: Centro de Estudios en Diabetes, México.
authors.forename: María Elena
authors.initials: ME
authors.lastname: González-Villalpando
mesh_terms: D000328:Adult; D000886:Anthropometry; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D050177:Overweight / Q000453:epidemiology; D010641:Phenotype; D011236:Prediabetic State / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors