title: Cyclopropanation using flow-generated diazo compounds.
abstract: We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. svl1000@cam.ac.uk.
authors.forename: Nuria M
authors.initials: NM
authors.lastname: Roda
authors.forename: Duc N
authors.initials: DN
authors.lastname: Tran
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Ricardo
authors.initials: R
authors.lastname: Labes
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ingham
authors.forename: Joel M
authors.initials: JM
authors.lastname: Hawkins
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001391:Azo Compounds; D003521:Cyclopropanes