title: Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues.
abstract: BACKGROUND
  Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) has been reported to be associated with the development of various cancers. However, the role of TRAF6 in lung cancer remains unclear.
  
  
  OBJECTIVE
  To explore the expression and clinicopathological significance of TRAF6 protein in lung cancer tissues.
  
  
  METHODS
  Three hundred and sixty-five lung cancer samples and thirty normal lung tissues were constructed into 3 microarrays. The expression of TRAF6 protein was determined using immunohistochemistry (IHC). Furthermore, correlations between the expression of TRAF6 and clinicopathological parameters were investigated.
  
  
  RESULTS
  The expression of TRAF6 in total lung cancer tissues (365 cases), as well as in small cell lung cancer (SCLC, 26 cases) and non-small cell lung cancer (NSCLC, 339 cases) was significantly higher compared with that in normal lung tissues. The ROC curve showed that the area under curve of TRAF6 was 0.663 (95%CI 0.570~0.756) for lung cancer. The diagnostic sensitivity and specificity of TRAF6 were 52.6% and 80%, respectively. In addition, the expression of TRAF6 was correlated with clinical TNM stage, tumor size and lymph node metastasis in all lung cancers. Consistent correlations were also observed for NSCLCs.
  
  
  CONCLUSIONS
  TRAF6 might be an oncogene and the expression of TRAF6 protein is related to the progression of lung cancer. Thus, TRAF6 might become a target for diagnosis and gene therapy for lung cancer patients.
authors.affiliation: Department of Pathology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China E-mail : chen_gang_triones@163.com.
authors.forename: Xiu-Ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Dang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Rong
authors.forename: Xin-Xi
authors.initials: XX
authors.lastname: Hou
authors.forename: Dian-Zhong
authors.initials: DZ
authors.lastname: Luo
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018287:Carcinoma, Large Cell / Q000378:metabolism / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000378:metabolism* / Q000556:secondary; D048029:TNF Receptor-Associated Factor 6 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D048029:TNF Receptor-Associated Factor 6