title: The cryptophycins as potent payloads for antibody drug conjugates.
abstract: The cryptophycins are a potent class of cytotoxic agents that were evaluated as antibody drug conjugate (ADC) payloads. Free cryptophycin analog 1 displayed cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1. This potency increase was also reflected in the activity of the cryptophycin ADCs, attached via a either cleavable or non-cleavable linker.
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: verma.vishal@gene.com.
authors.forename: Vishal A
authors.initials: VA
authors.lastname: Verma
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Pillow
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Laura
authors.initials: L
authors.lastname: DePalatis
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Guangmin
authors.initials: G
authors.lastname: Li
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Gail Lewis
authors.initials: GL
authors.lastname: Phillips
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Polson
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Helga E
authors.initials: HE
authors.lastname: Raab
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Spencer
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000627:therapeutic use*; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; D018796:Immunoconjugates
keywords: Antibody drug conjugate; Cryptophycin