title: Advances in the identification and characterization of olfactory receptors in insects.
abstract: Olfactory receptors (ORs) are the key elements of the molecular machinery responsible for the detection of odors in insects. Since their initial discovery in Drosophila melanogaster at the beginning of the twenty-first century, insect ORs have been the focus of intense research, both for fundamental knowledge of sensory systems and for their potential as novel targets for the development of products that could impact harmful behaviors of crop pests and disease vectors. In recent years, studies on insect ORs have entered the genomic era, with an ever-increasing number of OR genes being characterized every year through the sequencing of genomes and transcriptomes. With the upcoming release of genomic sequences from hundreds of insect species, the insect OR family could very well become the largest multigene family known. This extremely rapid identification of ORs in many insects is driving the necessity for the development of high-throughput technologies that will allow the identification of ligands for this unprecedented number of receptors. Moreover, such technologies will also be important for the development of agonists or antagonists that could be used in the fight against pest insects.
authors.affiliation: Institute of Ecology & Environmental Sciences of Paris, UPMC-Sorbonne Universités, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Montagné
authors.affiliation: Institute of Ecology & Environmental Sciences of Paris, INRA, Versailles, France.
authors.forename: Arthur
authors.initials: A
authors.lastname: de Fouchier
authors.affiliation: School of Biological Sciences, University of Auckland, Auckland, New Zealand; The New Zealand Institute for Plant & Food Research Limited, Auckland, New Zealand.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Newcomb
authors.affiliation: Institute of Ecology & Environmental Sciences of Paris, INRA, Versailles, France. Electronic address: emmanuelle.jacquin@versailles.inra.fr.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Jacquin-Joly
mesh_terms: D000818:Animals; D007313:Insecta / Q000502:physiology*; D009812:Odorants; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D018035:Receptors, Odorant / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018035:Receptors, Odorant
keywords: Deorphanization; Genomics; High-throughput screen; Insect; Olfactory receptor; Transcriptomics