title: Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women.
abstract: Metabolic disorders including type 2 diabetes, obesity and hypertension have growing prevalence globally every year. Genome-wide association studies have successfully identified many genetic markers associated to these diseases, but few studied their interaction effects. In this study, twenty candidate SNPs from sixteen genes are selected, and a lasso-multiple regression approach is implemented to consider the SNP-SNP interactions among them in an Asian population. It is found out that the main effects of the markers are weak but the interactions among the candidates showed a significant association to diseases. SNPs from genes CDKN2BAS and KCNJ11 are significantly associated to risk for developing diabetes, and SNPs from FTO and APOA5 might interact to play an important role for the onset of hypertension.
authors.affiliation: Division of Biostatistics, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: M H
authors.initials: MH
authors.lastname: Wang
authors.affiliation: School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: V S Y
authors.initials: VS
authors.lastname: Yeung
authors.affiliation: Division of Biostatistics, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: B C Y
authors.initials: BC
authors.lastname: Zee
authors.affiliation: Division of Epidemiology, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: R H Y
authors.initials: RH
authors.lastname: Yu
authors.affiliation: Division of Epidemiology, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: S
authors.initials: S
authors.lastname: Ho
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors.forename: M M Y
authors.initials: MM
authors.lastname: Waye
keywords: Candidate genes; Interaction effects; Metabolic disorder