title: Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study.
abstract: Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (<12) and long (>84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24-47 months (p < 0.05). The long IPI association was partially confounded by history of previous pregnancy loss.
authors: Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 789 WARF, 610 Walnut Street, Madison, WI, 53726, USA, mdurkin@wisc.edu.
authors: Maureen S
authors: MS
authors: Durkin
authors: Lindsay A
authors: LA
authors: DuBois
authors: Matthew J
authors: MJ
authors: Maenner
mesh_terms: D000067877:Autism Spectrum Disorder / Q000209:etiology*; D001721:Birth Intervals; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D012307:Risk Factors; D035781:Siblings; D014922:Wisconsin
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