title: The clinical value of faecal calprotectin and lactoferrin measurement in postoperative Crohn's disease.
abstract: Most patients with Crohn's disease (CD) ultimately require one or more operations over their lifetime. Nevertheless, surgery is not a cure and postoperative CD recurrence is common. Ileocolonoscopy has been considered to be the gold standard in the diagnosis and monitoring of postoperative recurrence in patients with CD. However, endoscopy is a time-consuming and invasive procedure. Simple and non-invasive methods for the detection of postoperative recurrence are desirable. Faecal inflammatory biomarkers such as calprotectin and lactoferrin provide an accurate and non-invasive diagnostic and monitoring modality for inflammatory bowel disease. However, there have been limited data on the role of faecal biomarkers in the postoperative setting. Recently, several studies evaluated the value of faecal calprotectin and lactoferrin measurement after surgery for CD. This review was conducted to assess the role of faecal calprotectin and lactoferrin measurements in patients with postoperative CD.
authors: Inflammatory Bowel Disease Centre and Department of Surgery, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.
authors: Takayuki
authors: T
authors: Yamamoto
keywords: Calprotectin; Crohn’s disease; endoscopic activity; faecal biomarker; lactoferrin; postoperative recurrence; surgery
references: Frontline Gastroenterol. 2011 Jan;2(1):13-18
references: 23904968
references: J Crohns Colitis. 2014 Aug;8(8):789-95
references: 24418661
references: United European Gastroenterol J. 2014 Feb;2(1):30-7
references: 24918006
references: Scand J Gastroenterol. 1992 Sep;27(9):793-8
references: 1411288
references: United European Gastroenterol J. 2013 Oct;1(5):368-74
references: 24917985
references: Eur Rev Med Pharmacol Sci. 2006 Jan-Feb;10 (1):17-22
references: 16494106
references: J Crohns Colitis. 2013 Dec;7(12):e700-1
references: 23953238
references: Inflamm Bowel Dis. 2014 Apr;20(4):742-56
references: 24562174
references: Aliment Pharmacol Ther. 2013 Mar;37(6):613-21
references: 23347334
references: Dig Dis Sci. 2012 May;57(5):1341-8
references: 22252267
references: Inflamm Bowel Dis. 2010 Jul;16(7):1091-2
references: 19834972
references: United European Gastroenterol J. 2013 Aug;1(4):294-8
references: 24917974
references: Gastroenterology. 1990 Oct;99(4):956-63
references: 2394349
references: J Crohns Colitis. 2013 Dec;7(12):e641-51
references: 23810085
references: Inflamm Bowel Dis. 2012 Oct;18(10):1894-9
references: 22238138
references: Dis Colon Rectum. 2007 Jun;50(6):861-9
references: 17473939
references: Inflamm Bowel Dis. 2014 Aug;20(8):1407-15
references: 24983982
references: Br J Surg. 2009 Jun;96(6):663-74
references: 19384912
references: Am J Gastroenterol. 2003 Jun;98(6):1309-14
references: 12818275
references: Clin Gastroenterol Hepatol. 2010 Jul;8(7):591-9.e1; quiz e78-9
references: 20139033