title: Inhibiting interleukin-18 production through the mitogen-activated protein kinase pathway, a potential role of corticotropin-releasing hormone in chronic plaque psoriasis.
abstract: Corticotropin-releasing hormone (CRH) and CRH receptors (CRH-Rs) are expressed in the skin; CRH-R1 is the predominant receptor. Whether the CRH/CRH-R1 system plays a role in psoriasis has not yet been assessed. Immunohistochemistry, real-time RT-PCR, ELISA assay, and Western blot analysis were used to investigate the expression of CRH/CRH-R1 in patients with chronic plaque psoriasis and that of IL-18 in CRH-treated HaCaT cells. CRH and CRH-R1 were downregulated in patients with chronic plaque psoriasis. In vitro, CRH attenuated the expression of IL-18 by a mitogen-activated protein kinase signaling pathway through CRH-R1 in HaCaT cells. Thus, an aberrant cutaneous CRH/CRH-R1 system exists in lesions from chronic plaque psoriasis which might play a role in psoriasis and offers further evidence for the study of CRH in the skin.
authors: Department of Dermatology, Qilu Hospital, Shandong University, No 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China.
authors: Chun-Lei
authors: CL
authors: Zhou
authors: Xiao-Jing
authors: XJ
authors: Yu
authors: Da-Xing
authors: DX
authors: Cai
authors: Yong-Hao
authors: YH
authors: Xu
authors: Chun-Yang
authors: CY
authors: Li
authors: Qing
authors: Q
authors: Sun
mesh_terms: D000328:Adult; D002460:Cell Line; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000494:pharmacology; D015536:Down-Regulation; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000096:biosynthesis*; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D011565:Psoriasis / Q000473:pathology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D055815:Young Adult; D000099052:CRF Receptor, Type 1
chemical_list: D020382:Interleukin-18; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1; D003346:Corticotropin-Releasing Hormone; D020928:Mitogen-Activated Protein Kinases
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