title: Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris.
abstract: BACKGROUND
  C1q/TNF-related protein 1 (CTRP-1), a novel adipocyte factor, may participate in the mechanisms of metabolism and inflammation. Interleukin 6 (IL-6) is a proinflammatory cytokine that is correlated with the severity of coronary heart disease (CHD). In this study, we focused on the levels of CTRP-1 and IL-6 in patients with CHD.
  
  
  METHODS
  Circulating CTRP-1 and IL-6 levels were measured using enzyme-linked immunosorbent assay in 81 patients with acute coronary syndrome (n=41) or stable angina pectoris (n=40). CTRP-1 and IL-6 levels were also examined in 30 healthy individuals (control group). We examined the correlations between the levels of CTRP-1 and IL-6 and cardiac risk factors in CHD. Logistic regression analysis was performed to screen for factors that predict CHD.
  
  
  RESULTS
  Both CTRP-1 and IL-6 concentrations were increased in the acute coronary syndrome or stable angina pectoris group compared with the control group (P<0.01). Both plasma levels of CTRP-1 and IL-6 in the single-, double- and triple-vessel lesion group were higher compared with the control group (P<0.01). CTRP-1 levels were positively correlated with IL-6 (r=0.667, P<0.01) and high-sensitivity C-reactive protein levels (r=0.520, P<0.01) and negatively correlated with HDL-C (r=-0.432, P<0.01). The logistic regression analysis showed that increases in CTRP-1 and IL-6 levels may be powerful predictors of CHD.
  
  
  CONCLUSIONS
  The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. This potential suggests that evaluating CTRP-1 and IL-6 in combination may aid in predicting the occurrence of CHD.
authors: Department of Cardiology (J-NT, D-LS, C-LL, X-FW, LZ, X-XX, J-YZ), the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Institute of Clinical Medicine (J-NT), the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; and College of Public Health (L-LC), Zhengzhou University, Zhengzhou, China.
authors: Jun-Nan
authors: JN
authors: Tang
authors: De-Liang
authors: DL
authors: Shen
authors: Cong-Lin
authors: CL
authors: Liu
authors: Xiao-Fang
authors: XF
authors: Wang
authors: Li
authors: L
authors: Zhang
authors: Xue-Xi
authors: XX
authors: Xuan
authors: Ling-Ling
authors: LL
authors: Cui
authors: Jin-Ying
authors: JY
authors: Zhang
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: C512356:C1QTNF1 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D011506:Proteins; D002097:C-Reactive Protein