title: Pharmacokinetics interaction between imatinib and genistein in rats.
abstract: The objective of this work was to investigate the effect of orally administered genistein on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats. Twenty-five healthy male SD (Sprague-Dawley) rats were randomly divided into five groups: A group (control group), B group (multiple dose of 100 mg/kg genistein for consecutive 15 days), C group (multiple dose of 50 mg/kg genistein for consecutive 15 days), D group (a single dose of 100 mg/kg genistein), and E group (a single dose of 50 mg/kg genistein). A single dose of imatinib is administered orally 30 min after administration of genistein (100 mg/kg or 50 mg/kg). The pharmacokinetic parameters of imatinib and N-desmethyl imatinib were calculated by DAS 3.0 software. The multiple dose of 100 mg/kg or 50 mg/kg genistein significantly (P < 0.05) decreased the AUC0-t and C max of imatinib. AUC0-t and the C max of N-desmethyl imatinib were also increased, but without any significant difference. However, the single dose of 100 mg/kg or 50 mg/kg genistein has no effect on the pharmacokinetics of imatinib and N-desmethyl imatinib. Those results indicated that multiple dose of genistein (100 mg/kg or 50 mg/kg) induces the metabolism of imatinib, while single dose of genistein has no effect.
authors: Department of Pharmacy, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Zhe
authors: Z
authors: Wang
authors: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Li
authors: L
authors: Wang
authors: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Meng-Ming
authors: MM
authors: Xia
authors: Department of Pharmacy, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Wei
authors: W
authors: Sun
authors: Department of Pharmacy, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Cheng-Ke
authors: CK
authors: Huang
authors: Department of Pharmacy, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Xiao
authors: X
authors: Cui
authors: School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Guo-Xin
authors: GX
authors: Hu
authors: Zhejiang Province Key Laboratory of Anesthesiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China ; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Qing-Quan
authors: QQ
authors: Lian
authors: Department of Pharmacy, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors: Zeng-Shou
authors: ZS
authors: Wang
mesh_terms: D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D019833:Genistein / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000068877:Imatinib Mesylate; D008297:Male; D013058:Mass Spectrometry; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019833:Genistein
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