title: Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement.
abstract: BACKGROUND
  Insufficiency in vitamin D, a neurosteroid hormone, is associated with cognitive decline in older adults. The impact on the subjective perception of cognitive decline has not yet been examined. The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients.
  
  
  METHODS
  Ninety-nine consecutive Caucasian in- and outpatients recruited in the 'Cognition and LIPophilic vitamins' (CLIP) study, who had no advanced cognitive disorders (i.e., Mini-Mental State Examination score≥20) and who took no vitamin D supplements, were categorized into 2 groups based on vitamin D insufficiency (i.e., serum 25-hydroxyvitamin D≥75 nmol/L). Subjective cognitive complaint was examined using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). MAC-Q score<15 out of 30 defined severe cognitive complaint. Age, gender, body mass index, education level, comorbidity burden, functional autonomy, mood, and serum concentrations of parathyroid hormone, calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate were used as potential confounders.
  
  
  RESULTS
  Compared to participants with serum 25OHD>75 nmol/L, those with vitamin D insufficiency (n=89) had a lower mean MAC-Q score (14.9±2.9 versus 17.1±1.6, P=0.02) and more often a MAC-Q score<15 (52.8% versus 10.0%, P=0.01). Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted β=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03).
  
  
  CONCLUSIONS
  Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients.
authors: Elena De Neree
authors: Ede N
authors: Tot Babberich
authors: Clemence
authors: C
authors: Gourdeau
authors: Simon
authors: S
authors: Pointel
authors: Bruno
authors: B
authors: Lemarchant
authors: Olivier
authors: O
authors: Beauchet
authors: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers Cedex 9, France. CeAnnweiler@chu-angers.fr.
authors: Cedric
authors: C
authors: Annweiler
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000523:psychology*; D003072:Cognition Disorders / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology / Q000523:psychology*; D044465:White People
chemical_list: D014807:Vitamin D