title: Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, Actinoallomurus fulvus MK10-036.
abstract: Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.
authors: Graduate School of Infection Control Sciences, ‡Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, and §Kitasato Institute for Life Sciences, Kitasato University , 5-9-1, Shirokane, Minato-ku, Tokyo, Japan.
authors: Yuki
authors: Y
authors: Inahashi
authors: Masato
authors: M
authors: Iwatsuki
authors: Aki
authors: A
authors: Ishiyama
authors: Atsuko
authors: A
authors: Matsumoto
authors: Tomoyasu
authors: T
authors: Hirose
authors: Jun
authors: J
authors: Oshita
authors: Toshiaki
authors: T
authors: Sunazuka
authors: Watanalai
authors: W
authors: Panbangred
authors: Yoko
authors: Y
authors: Takahashi
authors: Marcel
authors: M
authors: Kaiser
authors: Kazuhiko
authors: K
authors: Otoguro
authors: Satoshi
authors: S
authors: Ōmura
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D014344:Trypanocidal Agents / Q000737:chemistry*; D014346:Trypanosoma brucei brucei / Q000737:chemistry* / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D014344:Trypanocidal Agents; C000600940:actinoallolide A