title: Repetitive motor behavior: further characterization of development and temporal dynamics.
abstract: Repetitive behaviors are diagnostic for autism spectrum disorders, common in related neurodevelopmental disorders, and normative in typical development. In order to identify factors that mediate repetitive behavior development, it is necessary to characterize the expression of these behaviors from an early age. Extending previous findings, we characterized further the ontogeny of stereotyped motor behavior both in terms of frequency and temporal organization in deer mice. A three group trajectory model provided a good fit to the frequencies of stereotyped behavior across eight developmental time points. Group based trajectory analysis using a measure of temporal organization of stereotyped behavior also resulted in a three group solution. Additionally, as the frequency of stereotyped behavior increased with age, the temporal distribution of stereotyped responses became increasingly regular or organized indicating a strong association between these measures. Classification tree and principal components analysis showed that accurate classification of trajectory group could be done with fewer observations. This ability to identify trajectory group membership earlier in development allows for examination of a wide range of variables, both experiential and biological, to determine their impact on altering the expected trajectory of repetitive behavior across development. Such studies would have important implications for treatment efforts in neurodevelopmental disorders such as autism.
authors: Department of Psychiatry and McKnight Brain Institute, University of Florida, FL.
authors: Amber M
authors: AM
authors: Muehlmann
authors: Nikolay
authors: N
authors: Bliznyuk
authors: Isaac
authors: I
authors: Duerr
authors: Mark H
authors: MH
authors: Lewis
mesh_terms: D000367:Age Factors; D000818:Animals; D005260:Female; D008297:Male; D010542:Peromyscus / Q000254:growth & development / Q000502:physiology; D025341:Principal Component Analysis; D013239:Stereotyped Behavior / Q000145:classification / Q000502:physiology*
keywords: autism; clustering; deer mice; developmental trajectory; group trajectory modeling; neurodevelopmental disorders; stereotypy
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