title: Shortening the course of antibiotic treatment in the intensive care unit.
abstract: Effective antimicrobial stewardship is an increasingly important concern for healthcare providers globally. Antibiotics are frequently prescribed for patients who develop sepsis in the intensive care unit and traditionally courses are prolonged, with uncertain benefit and probable harm. There is little evidence to support many guidelines recommending between 10 and 14 days, and a number of studies suggest substantially shorter courses of less than 7 days may suffice. Safely reducing course length is likely to depend on a number of preconditions, including thorough eradication of any septic foci; optimization of serum antibiotic concentrations, particularly when there is physiological derangement; and use of novel biomarkers such as procalcitonin. The critical care environment is well suited to this aim as patients are closely monitored. With these measures in place, it is reasonable to believe short antibiotic courses can safely be used for the majority of intensive care infections.
authors: Department of Infectious Diseases, Kings College London and Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
authors: Jessica
authors: J
authors: Barrett
authors: Jonathan
authors: J
authors: Edgeworth
authors: Duncan
authors: D
authors: Wyncoll
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016470:Bacteremia / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016638:Critical Illness; D004334:Drug Administration Schedule; D004755:Enterobacteriaceae / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D006193:Haemophilus influenzae / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D011498:Protein Precursors / Q000097:blood; D011549:Pseudomonas / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: antibiotic; bloodstream infection; critical illness; intensive care; pharmacokinetics; reducing course length; ventilator-associated pneumonia