title: [Glaucoma: trends in the study of its etiology].
abstract: BACKGROUND
  There are different etiologies related to glaucoma, with the involvement of different systems in the origin and development of the disease.
  
  
  METHODS
  We performed a literature review.
  
  
  RESULTS
  The data is divided, with an emphasis on five main topics: systemic disease, neurodegenerative disease, genetic disease, immunological disease, and aging of the trabecular meshwork. Older and recent important findings of each subject are reported to establish a relationship with glaucoma, and mention is made of some of the current research lines.
  
  
  CONCLUSIONS
  Glaucoma is a multifactorial disease with complex interaction of events at various levels of the organism. Study of the etiology should guide the search for new therapies.
authors: Departamento de Glaucoma, Instituto de Oftalmología «Conde de Valenciana», México, D.F.
authors: Juan Carlos
authors: JC
authors: Serna-Ojeda
authors: Departamento de Glaucoma, Instituto de Oftalmología «Conde de Valenciana», México, D.F.
authors: Elsa María
authors: EM
authors: Flores-Reyes
authors: Departamento de Glaucoma, Instituto de Oftalmología «Conde de Valenciana», México, D.F.
authors: Curt
authors: C
authors: Hartleben-Matkin