title: Methods to measure olfactory behavior in mice.
abstract: Mice rely on the sense of olfaction to detect food sources, recognize social and mating partners, and avoid predators. Many behaviors of mice, including learning and memory, social interaction, fear, and anxiety are closely associated with their function of olfaction, and behavior tasks designed to evaluate those brain functions may use odors as cues. Accurate assessment of olfaction is not only essential for the study of olfactory system but also critical for proper interpretation of various mouse behaviors, especially learning and memory, emotionality and affect, and sociality. Here we describe a series of behavior experiments that offer multidimensional and quantitative assessments for mouse olfactory function, including olfactory habituation, discrimination, odor preference, odor detection sensitivity, and olfactory memory, with respect to both social and nonsocial odors.
authors: Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
authors: Junhui
authors: J
authors: Zou
authors: Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
authors: Wenbin
authors: W
authors: Wang
authors: Graduate Program, Molecular and Cellular Biology, University of Washington, Seattle, Washington.
authors: Yung-Wei
authors: YW
authors: Pan
authors: Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.
authors: Song
authors: S
authors: Lu
authors: Toxicology Program, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington.|Graduate Program, Molecular and Cellular Biology, University of Washington, Seattle, Washington.
authors: Zhengui
authors: Z
authors: Xia
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003463:Cues; D004192:Discrimination, Psychological; D006185:Habituation, Psychophysiologic; D006799:Housing, Animal; D008568:Memory; D051379:Mice; D023421:Models, Animal; D009812:Odorants; D055696:Olfactory Perception; D012903:Smell; D057188:Workflow
keywords: mouse; olfaction; olfactory discrimination; olfactory learning and memory
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