title: Research of electrosurgical unit with novel antiadhesion composite thin film for tumor ablation: Microstructural characteristics, thermal conduction properties, and biological behaviors.
abstract: The objective of this study was to use surface functionalization to evaluate the antiadhesion property and thermal injury effects on the liver when using a novel electrosurgical unit with nanostructured-doped diamond-like carbon (DLC-Cu) thin films for tumor ablations. The physical and chemical properties of DLC-Cu thin films were characterized by contact angle goniometer, scanning electron microscope, and transmission electron microscope. Three-dimensional (3D) hepatic models were reconstructed using magnetic resonance imaging to simulate a clinical electrosurgical operation. The results indicated a significant increase of the contact angle on the nanostructured DLC-Cu thin films, and the antiadhesion properties were also observed in an animal model. Furthermore, the surgical temperature in the DLC-Cu electrosurgical unit was found to be significantly lower than the untreated unit when analyzed using 3D models and thermal images. In addition, DLC-Cu electrodes caused a relatively small injury area and lateral thermal effect. The results indicated that the nanostructured DLC-Cu thin film coating reduced excessive thermal injury and tissue adherence effect in the liver.
authors: Department of Ophthalmology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.
authors: Yun-Dun
authors: YD
authors: Shen
authors: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, 110, Taiwan.|School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan.
authors: Li-Hsiang
authors: LH
authors: Lin
authors: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, 110, Taiwan.|School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan.|Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, 235, Taiwan.
authors: Hsi-Jen
authors: HJ
authors: Chiang
authors: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, 110, Taiwan.|Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, 235, Taiwan.|Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, 110, Taiwan.|Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, 110, Taiwan.
authors: Keng-Liang
authors: KL
authors: Ou
authors: Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, 110, Taiwan.|Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, 110, Taiwan.|Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, 110, Taiwan.
authors: Han-Yi
authors: HY
authors: Cheng
mesh_terms: D000818:Animals; D004598:Electrosurgery / Q000379:methods*; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008297:Male; D008567:Membranes, Artificial; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D008567:Membranes, Artificial
keywords: DLC-Cu thin film; antiadhesion; biomechanics; tissue engineering