title: Role of obesity and adipose tissue-derived cytokine leptin during Clostridium difficile infection.
abstract: Obesity is among the most pressing health concerns in the world since it is increasingly common even in the developing world, and is clearly associated with increased risk for chronic debilitating diseases and death. Furthermore, obesity can influence the pathogenesis of infectious diseases by affecting the balance of pathogen clearance and pathological inflammation. The mechanisms that result in enhanced inflammation in obese individuals are poorly understood. Clostridium difficile is a major cause of nosocomial infections worldwide. Recent studies have shown that obesity is associated with increased risk of C. difficile infections. In this review, we will discuss our current knowledge of the role of obesity in determining risk of C. difficile infections, and focus on the role of the adipose tissue-derived cytokine leptin in C. difficile infections.
authors: Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Charlottesville, VA 22908, USA. Electronic address: rajat.madan@uc.edu.
authors: Rajat
authors: R
authors: Madan
authors: Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, USA; Department of Pathology, University of Virginia, USA. Electronic address: wap3g@virginia.edu.
authors: William A
authors: WA
authors: Petri
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D016360:Clostridioides difficile / Q000502:physiology*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000150:complications*
chemical_list: D020738:Leptin
keywords: Adipocytokine; Clostridium difficile; Leptin; Obesity
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