title: Air pollution as a risk factor for type 2 diabetes.
abstract: Recent studies in both humans and animals suggest that air pollution is an important risk factor for type 2 diabetes mellitus (T2DM). However, the mechanism by which air pollution mediates propensity to diabetes is not fully understood. While a number of epidemiologic studies have shown a positive association between ambient air pollution exposure and risk for T2DM, some studies have not found such a relationship. Experimental studies in susceptible disease models do support this association and suggest the involvement of tissues involved in the pathogenesis of T2DM such as the immune system, adipose, liver, and central nervous system. This review summarizes the epidemiologic and experimental evidence between ambient outdoor air pollution and T2DM.
authors: *Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park.
authors: Xiaoquan
authors: X
authors: Rao
authors: *Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park.
authors: Priti
authors: P
authors: Patel
authors: *Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park.
authors: Robin
authors: R
authors: Puett
authors: *Division of Cardiovascular Medicine, University of Maryland, Baltimore and Maryland Institute for Applied Environmental Health, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park srajagopalan@medicine.umaryland.edu.
authors: Sanjay
authors: S
authors: Rajagopalan
mesh_terms: D000393:Air Pollutants / Q000737:chemistry / Q000633:toxicity; D000397:Air Pollution / Q000009:adverse effects*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D052638:Particulate Matter / Q000737:chemistry / Q000633:toxicity; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter
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