title: Complications of peripherally inserted central catheters in adults with cystic fibrosis or bronchiectasis.
abstract: BACKGROUND
  Peripherally inserted central catheters (PICCs) are increasingly used in patients with cystic fibrosis (CF) or with non-CF bronchiectasis, but little data exist on catheter-related complications in this setting.
  
  
  METHODS
  Prospective follow-up of consecutive PICCs inserted for intravenous (IV) antibiotics in adults with CF or with non-CF bronchiectasis at Cochin Hospital (Paris, France).
  
  
  RESULTS
  Between March 2009 and December 2011, 182 PICCs were prescribed in 117 adults (67 CF and 50 non-CF patients). Ultrasound-guided placement of catheter was successful in 174/182 (95.6%) procedures; no insertion complication occurred. The mean ± SD catheter dwell time was 15 ± 9 days. No catheter-associated bloodstream infection occurred; main complications were symptomatic upper limb deep vein thrombosis (2%), catheter obstruction (18%) and persistent pain after catheter insertion (18%). Patients' satisfaction was high and PICC could be used to perform antibiotic courses in most patients.
  
  
  CONCLUSIONS
  PICCs were generally safe for performing IV antibiotic courses in patients with CF or non-CF bronchiectasis, but prolonged pain and/or catheter obstruction occurred in approximately 20% of cases.
authors: 2 Université Paris Descartes, Sorbonne Paris Cité, Paris - France.
authors: Christian
authors: C
authors: Dupont
authors: Hervé
authors: H
authors: Gouya
authors: Rozy
authors: R
authors: Panzo
authors: Dominique
authors: D
authors: Hubert
authors: Jean-Michel
authors: JM
authors: Correas
authors: Line
authors: L
authors: Agrario
authors: Jeanne
authors: J
authors: Chapron
authors: Isabelle
authors: I
authors: Honoré
authors: Reem
authors: R
authors: Kanaan
authors: Paul
authors: P
authors: Legmann
authors: Daniel
authors: D
authors: Dusser
authors: Olivier
authors: O
authors: Vignaux
authors: Pierre-Régis
authors: PR
authors: Burgel
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001987:Bronchiectasis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D061807:Catheter Obstruction / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D002406:Catheterization, Peripheral / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D002408:Catheters, Indwelling; D062905:Central Venous Catheters; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010297:Paris; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents