title: Immunologic manifestations of autophagy.
abstract: The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.
authors: Vojo
authors: V
authors: Deretic
authors: Tomonori
authors: T
authors: Kimura
authors: Graham
authors: G
authors: Timmins
authors: Pope
authors: P
authors: Moseley
authors: Santosh
authors: S
authors: Chauhan
authors: Michael
authors: M
authors: Mandell
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001343:Autophagy; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010587:Phagocytosis; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000473:pathology
references: Sci Signal. 2010;3(123):ra42
references: 20501938
references: Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16079-84
references: 24043792
references: EMBO Mol Med. 2011 Sep;3(9):513-27
references: 21826793
references: Cell Mol Life Sci. 2012 Mar;69(6):963-79
references: 21964925
references: Nature. 2011 Jan 13;469(7329):221-5
references: 21124315
references: Nat Med. 2009 Mar;15(3):267-76
references: 19252503
references: Science. 2006 Sep 8;313(5792):1438-41
references: 16888103
references: J Immunol. 2009 Apr 1;182(7):4046-55
references: 19299702
references: Virology. 2014 May;456-457:87-95
references: 24889228
references: J Cell Biol. 2009 Jul 27;186(2):255-68
references: 19635843
references: Immunity. 2010 Feb 26;32(2):227-39
references: 20171125
references: Int J Epidemiol. 2008 Feb;37(1):113-9
references: 18245055
references: Nature. 2013 Jun 20;498(7454):332-7
references: 23722159
references: Sci Transl Med. 2011 Oct 12;3(104):104ra102
references: 21998409
references: Cell Host Microbe. 2012 Jun 14;11(6):563-75
references: 22704617
references: Am J Hum Genet. 2013 Jan 10;92(1):41-51
references: 23273568
references: Cell. 2012 Aug 17;150(4):803-15
references: 22901810
references: Mol Cell. 2007 Jan 26;25(2):193-205
references: 17244528
references: Immunity. 2007 Jul;27(1):135-44
references: 17658277
references: PLoS Pathog. 2012 Feb;8(2):e1002517
references: 22319449
references: Eur J Immunol. 2012 Apr;42(4):880-9
references: 22531915
references: PLoS One. 2014;9(3):e93143
references: 24671203
references: Nat Cell Biol. 2013 Jul;15(7):741-50
references: 23685627
references: Cell. 2007 Jun 29;129(7):1287-98
references: 17604718
references: Cell Host Microbe. 2014 May 14;15(5):564-77
references: 24832451
references: Autophagy. 2011 Mar;7(3):279-96
references: 21189453
references: J Virol. 2014 Jan;88(2):890-902
references: 24198400
references: Immunity. 2012 Jun 29;36(6):947-58
references: 22658522
references: Cell. 2004 Dec 17;119(6):753-66
references: 15607973
references: Immunity. 2012 Aug 24;37(2):223-34
references: 22921120
references: BMC Immunol. 2008;9:35
references: 18627610
references: Science. 2013 Feb 15;339(6121):786-91
references: 23258413
references: Cell Host Microbe. 2014 Feb 12;15(2):228-38
references: 24528868
references: Cell Host Microbe. 2014 Feb 12;15(2):239-47
references: 24528869
references: J Immunol. 2011 Nov 15;187(10):5051-61
references: 22021616
references: J Proteome Res. 2011 Jan 7;10(1):339-48
references: 21105745
references: J Biol Chem. 2011 Jul 29;286(30):26987-95
references: 21646350
references: Nature. 2012 Nov 1;491(7422):119-24
references: 23128233
references: Autophagy. 2012 Sep;8(9):1357-70
references: 22885411
references: F1000 Biol Rep. 2010 Jun 23;2:null
references: 20948788
references: Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704
references: 24302768
references: Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6031-6
references: 17389386
references: Cell. 2013 Jan 17;152(1-2):290-303
references: 23332761
references: Mol Cell. 2011 Oct 21;44(2):279-89
references: 22017874
references: J Immunol. 2011 Feb 1;186(3):1564-74
references: 21191072
references: Cell Host Microbe. 2012 Nov 15;12(5):669-81
references: 23159056
references: Dev Cell. 2014 Aug 25;30(4):394-409
references: 25127057
references: Sci Signal. 2013 Feb 5;6(261):ra9
references: 23386746
references: Science. 2011 Jul 8;333(6039):228-33
references: 21617041
references: Mol Cell. 2009 Feb 27;33(4):505-16
references: 19250911
references: Immunity. 2012 Dec 14;37(6):986-97
references: 23219390
references: J Biol Chem. 2013 May 24;288(21):14959-72
references: 23576438
references: Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5
references: 17709747
references: Nat Med. 2014 May;20(5):503-10
references: 24747745
references: Gastroenterology. 2012 Jun;142(7):1493-503.e6
references: 22370477
references: J Cell Biol. 2013 Dec 9;203(5):757-66
references: 24322427
references: Nat Rev Immunol. 2013 Oct;13(10):722-37
references: 24064518
references: Science. 2010 Jun 25;328(5986):1703-5
references: 20508090
references: Nat Immunol. 2009 Nov;10(11):1215-21
references: 19820708
references: Immunity. 2010 May 28;32(5):654-69
references: 20451412
references: Science. 2005 Jan 28;307(5709):593-6
references: 15591165
references: Immunity. 2013 Sep 19;39(3):537-47
references: 24035364
references: Nature. 2013 Feb 21;494(7437):323-7
references: 23389440
references: Cell Death Differ. 2013 Feb;20(2):188-97
references: 23175183
references: Nature. 2008 Sep 18;455(7211):396-400
references: 18701890
references: Nature. 2008 Nov 13;456(7219):264-8
references: 18849965
references: Cell. 2013 Sep 12;154(6):1285-99
references: 24034251
references: Infect Immun. 2013 Jan;81(1):2-10
references: 23071135
references: PLoS Genet. 2011 Dec;7(12):e1002406
references: 22174698
references: PLoS One. 2012;7(11):e50672
references: 23209807
references: Nat Cell Biol. 2011 Feb;13(2):132-41
references: 21258367
references: J Exp Med. 2011 Dec 19;208(13):2625-32
references: 22162830
references: Nat Cell Biol. 2010 Sep;12(9):831-5
references: 20811355
references: Cell Host Microbe. 2007 Mar 15;1(1):23-35
references: 18005679
references: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5514-9
references: 16540544
references: Nat Genet. 2009 Dec;41(12):1313-8
references: 19898481
references: Inflamm Bowel Dis. 2011 Jun;17(6):1392-7
references: 21560199
references: J Cell Biol. 2005 Nov 21;171(4):603-14
references: 16286508
references: Immunity. 2013 Aug 22;39(2):211-27
references: 23973220
references: Nat Cell Biol. 2011 Sep;13(9):1016-23
references: 21892142
references: Nat Immunol. 2013 Mar;14(3):298-305
references: 23354484
references: Cell Host Microbe. 2014 Feb 12;15(2):214-27
references: 24528867
references: Nature. 2011 Oct 27;478(7370):515-8
references: 21947006
references: J Crohns Colitis. 2012 Feb;6(1):43-50
references: 22261526
references: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2770-5
references: 19196953
references: EMBO J. 2008 Apr 9;27(7):1110-21
references: 18337753
references: Nat Cell Biol. 2013 Apr;15(4):406-16
references: 23524951
references: Cell Host Microbe. 2009 Sep 17;6(3):231-43
references: 19748465
references: Immunity. 2014 Jan 16;40(1):51-65
references: 24374193
references: Autophagy. 2010 Feb;6(2):288-9
references: 20104023
references: PLoS Pathog. 2012;8(5):e1002689
references: 22589721
references: J Biol Chem. 2014 Feb 21;289(8):5000-12
references: 24356959
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6
references: 19926846
references: Nat Immunol. 2011 Mar;12(3):222-30
references: 21151103
references: Cell. 2014 Feb 27;156(5):1045-59
references: 24581500
references: Nat Med. 2010 Jan;16(1):90-7
references: 19966812
references: Mol Cell. 2012 Dec 14;48(5):667-80
references: 23084476
references: PLoS One. 2012;7(4):e33454
references: 22536318
references: J Cell Biol. 2010 Sep 6;190(5):881-92
references: 20819940
references: Virology. 2013 Mar 1;437(1):12-9
references: 23290079
references: Nat Cell Biol. 2010 Dec;12(12):1154-65
references: 21102437
references: Med Microbiol Immunol. 2014 Oct;203(5):323-31
references: 24824868
references: J Immunol. 2014 Jun 15;192(12):5952-62
references: 24808366
references: Nature. 2007 Jun 7;447(7145):661-78
references: 17554300
references: Nature. 2012 Feb 16;482(7385):414-8
references: 22246324
references: Nat Genet. 2009 Nov;41(11):1234-7
references: 19838193
references: Cell Host Microbe. 2012 Dec 13;12(6):778-90
references: 23245322
references: Cell Host Microbe. 2012 Mar 15;11(3):277-89
references: 22423967
references: Am J Transplant. 2014 Mar;14(3):545-53
references: 24502356
references: PLoS Pathog. 2010;6(12):e1001230
references: 21187903
references: Science. 2011 Jan 28;331(6016):456-61
references: 21205641
references: Science. 2014 Jan 17;343(6168):313-7
references: 24310610
references: Annu Rev Cell Dev Biol. 2011;27:107-32
references: 21801009
references: J Infect Dis. 2012 May 1;205(9):1425-35
references: 22457295
references: Immunity. 2007 Sep;27(3):505-17
references: 17892853
references: Immunity. 2007 Jan;26(1):79-92
references: 17182262
references: J Immunol. 2011 Feb 1;186(3):1646-55
references: 21209283
references: Nature. 2013 Jun 20;498(7454):380-4
references: 23722158
references: Nat Immunol. 2014 Dec;15(12):1152-61
references: 25362489
references: Cell. 2013 Oct 24;155(3):688-98
references: 24119841
references: Nat Genet. 2008 Feb;40(2):204-10
references: 18204446
references: J Biol Chem. 2011 Mar 18;286(11):9587-97
references: 21228274
references: Immunity. 2008 Jun;28(6):799-809
references: 18513998
references: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76
references: 23093667
references: Immunity. 2010 Mar 26;32(3):329-41
references: 20206555
references: Annu Rev Cell Dev Biol. 2004;20:367-94
references: 15473845
references: J Biol Chem. 2012 Apr 13;287(16):12668-78
references: 22275355
references: Nature. 2008 Nov 13;456(7219):259-63
references: 18849966
references: EMBO J. 2011 Nov 30;30(23):4701-11
references: 22068051
references: Nature. 2010 Apr 1;464(7289):713-20
references: 20360734
references: Nature. 2007 Dec 20;450(7173):1253-7
references: 18097414
references: Nat Immunol. 2012 Mar;13(3):255-63
references: 22286270
references: EMBO J. 2007 Apr 4;26(7):1749-60
references: 17347651
references: Nat Immunol. 2010 Jan;11(1):55-62
references: 19898471
references: Cell Host Microbe. 2009 Aug 20;6(2):137-49
references: 19683680
references: Curr Biol. 2014 Mar 17;24(6):609-20
references: 24613307
references: J Exp Med. 2011 Mar 14;208(3):455-67
references: 21339326
references: Cell. 2010 Mar 5;140(5):731-43
references: 20211141
references: J Exp Med. 2013 Feb 11;210(2):287-300
references: 23382543
references: Nat Immunol. 2013 May;14(5):480-8
references: 23525089
references: Nature. 2011 Jan 20;469(7330):323-35
references: 21248839
references: Mol Immunol. 2011 Jan;48(4):720-7
references: 21095008
references: Autophagy. 2014 Apr;10(4):549-51
references: 24657946
references: Cell Host Microbe. 2009 Oct 22;6(4):367-80
references: 19837376
references: Gastroenterology. 2013 Aug;145(2):339-47
references: 23624108
references: J Immunol. 2013 Mar 15;190(6):2791-806
references: 23418629
references: Science. 2007 Mar 9;315(5817):1398-401
references: 17272685
references: Science. 2004 Nov 5;306(5698):1037-40
references: 15528445
references: Nature. 2013 Sep 26;501(7468):512-6
references: 24005326
references: Nat Genet. 2013 Jan;45(1):83-7
references: 23222957
references: PLoS One. 2013;8(12):e86017
references: 24376899