title: Genome-wide detection and characterization of positive selection in Korean Native Black Pig from Jeju Island.
abstract: BACKGROUND
  In the 1980s, Korean native black pigs from Jeju Island (Jeju black pigs) served as representative sample of Korean native black pigs, and efforts were made to help the species rebound from the brink of extinction, which occurred as a result of the introduction of Western pig breeds. Geographical separation of Jeju Island from the Korean peninsula has allowed Jeju black pigs not only to acquire unique characteristics but also to retain merits of rare Korean native black pigs.
  
  
  RESULTS
  To further analyze the Jeju black pig genome, we performed whole-genome re-sequencing (average read depth of 14×) of 8 Jeju black pig and 6 Korean pigs (which live on the Korean peninsula) to compare and identify putative signatures of positive selection in Jeju black pig, the true and pure Korean native black pigs. The candidate genes potentially under positive selection in Jeju black pig support previous reports of high marbling score, rare occurrence of pale, soft, exudative (PSE) meat, but low growth rate and carcass weight compared to Western breeds.
  
  
  CONCLUSIONS
  Several candidate genes potentially under positive selection were involved in fatty acid transport and may have contributed to the unique characteristics of meat quality in JBP. Jeju black pigs can offer a unique opportunity to investigate the true genetic resource of once endangered Korean native black pigs. Further genome-wide analyses of Jeju black pigs on a larger population scale are required in order to define a conservation strategy and improvement of native pig resources.
authors: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Korea. jmkim85@snu.ac.kr.
authors: Jaemin
authors: J
authors: Kim
authors: CHO&KIM genomics, Main Bldg. #514, SNU Research Park, Seoul National University Mt.4-2, NakSeoungDae, Gwanakgu, Seoul, 151-919, Republic of Korea. seoae@cnkgenomics.com.
authors: Seoae
authors: S
authors: Cho
authors: Department of Animal Sciences, University of Illinois, Urbana, IL, 61801, USA. kelseycy@gmail.com.
authors: Kelsey
authors: K
authors: Caetano-Anolles
authors: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Korea. heebal@snu.ac.kr.|CHO&KIM genomics, Main Bldg. #514, SNU Research Park, Seoul National University Mt.4-2, NakSeoungDae, Gwanakgu, Seoul, 151-919, Republic of Korea. heebal@snu.ac.kr.|Department of Agricultural Biotechnology and Research Institute of Population Genomics, Seoul National University, Seoul, 151-742, Republic of Korea. heebal@snu.ac.kr.
authors: Heebal
authors: H
authors: Kim
authors: Division of Biotechnology, The Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University, Jeju, 690-756, Republic of Korea. ycryu@jejunu.ac.kr.
authors: Youn-Chul
authors: YC
authors: Ryu
mesh_terms: D000818:Animals; D060467:Disease Resistance; D005227:Fatty Acids / Q000378:metabolism; D005787:Gene Frequency; D008460:Meat / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D012641:Selection, Genetic; D034421:Sus scrofa / Q000145:classification* / Q000235:genetics* / Q000378:metabolism
chemical_list: D005227:Fatty Acids
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