title: Role of CtBP2 in the Apoptosis of Retinal Ganglion Cells.
abstract: Glaucoma damages the optic nerve and is a leading cause of irreversible blindness, and its pathogenesis remains unclear. C-terminal-binding protein 2 (CtBP2) is a transcriptional repressor which plays an important role in central nervous system injury and repair. Using the glaucoma model of DBA/2J mouse whose retina ganglion cells (RGCs) were degenerating with the process of glaucoma, we demonstrated for the first time the special relationship between CtBP2 protein and RGCs. Our research indicated that the expression of CtBP2 was gradually decreased with aging by the means of Western blotting. The CtBP2 immunoreactivity-positive cells were present in the various retinal layers, and CtBP2-positive cells were dramatically decreased in ganglion cell layer. Our research also found ectopic expression of CtBP2 can protect the apoptosis of primary mouse RGC cells induced by L-glutamate. These results suggest that CtBP2 may have a potential therapeutic effect in protecting RGC.
authors: Department of Pathology of Traditional Chinese Medicine Hospital, Jiangyin, Jiangsu, China.
authors: Wenwen
authors: W
authors: Wang
authors: Guowei
authors: G
authors: Zhang
authors: Hui
authors: H
authors: Gu
authors: Ye
authors: Y
authors: Liu
authors: Jifeng
authors: J
authors: Lao
authors: Kuifang
authors: K
authors: Li
authors: Huaijin
authors: H
authors: Guan
mesh_terms: D000375:Aging / Q000378:metabolism; D000429:Alcohol Oxidoreductases; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018698:Glutamic Acid / Q000494:pharmacology; D007150:Immunohistochemistry; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010750:Phosphoproteins / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
chemical_list: D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D018698:Glutamic Acid; D000429:Alcohol Oxidoreductases; C111341:Ctbp2 protein, mouse
references: Trends Pharmacol Sci. 1990 Nov;11(11):462-8
references: 1980041
references: PLoS Genet. 2005 Jul;1(1):17-26
references: 16103918
references: J Neurosci Methods. 1991 Mar;37(1):7-14
references: 1677056
references: Vis Neurosci. 2005 Sep-Oct;22(5):637-48
references: 16332275
references: J Neuropathol Exp Neurol. 2009 Jul;68(7):747-56
references: 19535997
references: Eye (Lond). 2005 Apr;19(4):369-70
references: 15806116
references: Genes Cancer. 2011 May;2(5):523-37
references: 21901166
references: Med Sci Monit Basic Res. 2013 Dec 06;19:285-90
references: 24309384
references: Prog Retin Eye Res. 1999 Nov;18(6):765-810
references: 10530751
references: Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4564-72
references: 17898279
references: Cancer Res. 2009 Feb 1;69(3):731-4
references: 19155295
references: Mol Vis. 2012;18:2922-30
references: 23233794
references: Mol Cell Biol. 2002 Aug;22(15):5296-307
references: 12101226
references: Invest Ophthalmol Vis Sci. 2008 Feb;49(2):613-21
references: 18235006
references: Am J Pathol. 2005 Sep;167(3):673-81
references: 16127148
references: Vision Res. 2005 Jan;45(2):169-79
references: 15581918
references: Invest Ophthalmol Vis Sci. 2011 Jun 01;52(6):3654-9
references: 21330670
references: Chin Med J (Engl). 2007 Feb 20;120(4):326-35
references: 17374286
references: J Biomed Biotechnol. 2012;2012:692609
references: 22665989
references: Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5151-62
references: 14638711
references: Retina. 1982;2(4):341-59
references: 6152914
references: J Histochem Cytochem. 2012 Mar;60(3):219-28
references: 22356868
references: Cell Death Differ. 2010 Mar;17(3):513-21
references: 19798104
references: Exp Eye Res. 2009 Apr;88(4):816-24
references: 19105954
references: Cell Death Differ. 2014 Jan;21(1):172-84
references: 24141717
references: Exp Eye Res. 2010 Jul;91(1):48-53
references: 20394744
references: Invest Ophthalmol Vis Sci. 2006 Feb;47(2):626-33
references: 16431960
references: Prog Retin Eye Res. 2002 Sep;21(5):465-84
references: 12207946
references: Sci Rep. 2012;2:530
references: 22833783
references: J Neurophysiol. 1990 Jan;63(1):16-30
references: 2153770
references: Cell Cycle. 2010 Sep 15;9(18):3740-50
references: 20930544
references: Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4573-9
references: 17898280
references: Br J Ophthalmol. 2006 Mar;90(3):262-7
references: 16488940
references: J Neurosci. 2010 Sep 15;30(37):12387-99
references: 20844134
references: Bull World Health Organ. 2004 Nov;82(11):844-51
references: 15640920
references: Front Cell Neurosci. 2013 Jan 09;6:60
references: 23316132
references: J Neurosci. 2008 Mar 12;28(11):2735-44
references: 18337403
references: Cell Death Differ. 2006 Aug;13(8):1325-38
references: 16645634
references: Cell Death Dis. 2012 May 17;3:e309
references: 22592316
references: J Mol Histol. 2012 Jun;43(3):327-34
references: 22426895
references: J Mol Neurosci. 2013 Feb;49(2):395-408
references: 23076816
references: Neural Plast. 2013;2013:670254
references: 24175101
references: Exp Eye Res. 2007 Jan;84(1):13-21
references: 17074320
references: Int J Biochem Cell Biol. 2007;39(9):1593-607
references: 17336131