title: [Correlation between children's dental decay and the contents of saliva CCL28 and secretory immunoglobulin A].
abstract: OBJECTIVE
  To explore the association of the dental decay of children with the contents of chemokine CCL28 and secretory immunoglobulin A (sIgA) in saliva.
  
  
  METHODS
  A total of 108 children in 2 kindergartens of Changsha, with age from 3 to 5 years old, were enrolled for this study. The saliva was collected from these children when they were in the examination of mouth. Th e children were divided into 3 groups: A non-caries group [dynamical mean-field theory (DMFT)=0], a low caries group (DMFT=1-4) and a high caries group (DMFT ≥ 5). Th e contents of CCL28 and sIgA were measured by ELISA.
  
  
  RESULTS
  The contents of CCL28 and sIgA in saliva were (121.22 ± 32.63) pg/mL and (16.49 ± 8.02) μg/mL, respectively. A positive linear correlation was found between the CCL28 content and sIgA content in saliva (r=0.734). Th e CCL28 and sIgA contents in saliva were positively correlated with the degree of dental caries in children (P<0.05).
  
  
  CONCLUSIONS
  The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva.
authors: Cener of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
authors: Zhi
authors: Z
authors: Liu
authors: Guoying
authors: G
authors: Que
authors: Jinhuan
authors: J
authors: Li
authors: Jinxia
authors: J
authors: Deng
authors: Lulu
authors: L
authors: Li
authors: Tingting
authors: T
authors: Liu
authors: Da
authors: D
authors: Su
mesh_terms: D019742:Chemokines, CC / Q000032:analysis*; D002675:Child, Preschool; D003731:Dental Caries / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D012463:Saliva / Q000737:chemistry*
chemical_list: C414047:CCL28 protein, human; D019742:Chemokines, CC; D007071:Immunoglobulin A, Secretory