title: Blood pressure and arterial stiffness in patients with high sodium intake in relation to sodium handling and left ventricular diastolic dysfunction status.
abstract: In a population with high sodium consumption, we assessed relation between brachial and central blood pressures, elastic properties of large arteries, echocardiographic left ventricular diastolic function and sodium reabsorption as fractional urinary lithium excretion in proximal (FELi) and fractional sodium reabsorption in distal tubules assessed using the endogenous lithium clearance. Mean±s.d. age of 131 treated hypertensive patients (66 men and 65 women) was 61.9±7.5 years. We found significant interaction between left ventricular diastolic function and FELi with respect to the values of brachial blood pressure: systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) (all PINT<0.03). In patients with FELi below the median value and impaired left ventricular diastolic function, the values of SBP (149.3 vs 132.5 mm Hg; P=0.005), DBP (85.1 vs 76.1 mm Hg; P=0.001), MBP (106.5 vs 94.9 mm Hg; P=0.001), central SBP (SBPC) (137.4 vs 122.0 mm Hg; P=0.01), central DBP (DBPC) (84.8 vs 76.0 mm Hg; P=0.003), central MBP (MBPC) (106.9 vs 95.9 mm Hg; P=0.007), aortic pulse wave augmentation (18.0 vs 13.5 mm Hg; P=0.03), pulse wave velocity (14.6 vs 12.5 m s(-1); P=0.02) and central aortic pulse wave augmentation index (155.7% vs 140.9%; P=0.01) were significantly higher than in patients with normal left ventricular diastolic function. Such relationships were not observed in the entire group and patients with FELi above the median value. In the hypertensive population with high sodium intake, increased sodium reabsorption in proximal tubules may affect blood pressure parameters and arterial wall damage, thus contributing to the development of left ventricular diastolic function impairment.
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: M
authors: M
authors: Cwynar
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: J
authors: J
authors: Gąsowski
authors: Department of Nephrology, Hypertension and Internal Diseases, University of Warmia and Mazury, Olsztyn, Poland.
authors: T
authors: T
authors: Stompór
authors: Trace Element Research Laboratory, Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Krakow, Poland.
authors: H
authors: H
authors: Bartoń
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: B
authors: B
authors: Wizner
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: M
authors: M
authors: Dubiel
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: A
authors: A
authors: Głuszewska
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: J
authors: J
authors: Królczyk
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: P
authors: P
authors: Franczuk
authors: Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland.
authors: T
authors: T
authors: Grodzicki
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D059289:Vascular Stiffness / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D012982:Sodium, Dietary; D012964:Sodium
references: J Clin Pharmacol. 1989 Oct;29(10):928-37
references: 2687336
references: Hypertension. 2008 Jun;51(6):1643-50
references: 18413491
references: Circulation. 1985 Feb;71(2):202-10
references: 3965165
references: Anal Sci. 2009 May;25(5):639-43
references: 19430146
references: N Engl J Med. 1986 Jan 23;314(4):198-201
references: 3941708
references: Kidney Int Suppl. 1990 Mar;28:S45-51
references: 2182931
references: Anal Biochem. 1989 Nov 1;182(2):245-9
references: 2610339
references: Nephrol Dial Transplant. 2007 Sep;22(9):2426-9
references: 17556416
references: Kidney Int. 1981 Aug;20(2):240-5
references: 7026873
references: J Hypertens. 2005 May;23(5):961-9
references: 15834281
references: Hypertension. 2009 Sep;54(3):489-95
references: 19581508
references: Hypertension. 2013 Oct;62(4):719-25
references: 23959555
references: Eur Heart J. 2007 Oct;28(20):2539-50
references: 17428822
references: Eur Heart J. 1998 Jun;19(6):951-8
references: 9651721
references: Hypertension. 2010 Oct;56(4):584-90
references: 20733090
references: Hypertension. 2000 Oct;36(4):631-7
references: 11040249
references: Circulation. 2006 Mar 7;113(9):1213-25
references: 16476843
references: JAMA. 1993 Jul 21;270(3):354-9
references: 8315780
references: J Am Coll Cardiol. 2009 Aug 18;54(8):705-13
references: 19679248
references: Am J Cardiol. 1990 May 2;65(17):28H-32H
references: 2330906
references: Hypertension. 2001 Nov;38(5):1172-6
references: 11711517
references: Hypertension. 1994 Apr;23(4):496-502
references: 8144219
references: Hypertension. 2006 Oct;48(4):609-15
references: 16966578
references: Am J Physiol. 1998 May;274(5 Pt 2):H1423-8
references: 9612345
references: Hypertension. 1993 Sep;22(3):339-47
references: 8349327
references: J Hypertens. 1990 Nov;8(11):991-5
references: 1963190
references: Cardiovasc Res. 2000 May;46(2):269-76
references: 10773231
references: Hypertension. 2003 May;41(5):1000-5
references: 12668589
references: J Hypertens. 1996 Jul;14(7):909-14
references: 8818931
references: Hypertension. 1998 May;31(5):1083-7
references: 9576118