title: Uterine cervical cancer with brain metastasis as the initial site of presentation.
abstract: Brain metastasis from uterine cervical cancer is rare, with an incidence of 0.5%, and usually occurs late in the course of the disease. We report a case of uterine cervical cancer with brain metastasis as the initial site of presentation. A 50-year-old woman with headache, vertigo, amnesia and loss of appetite was admitted for persistent vomiting. Contrast enhanced computed tomography showed a solitary right frontal cerebral lesion with ring enhancement and uterine cervical tumor. She was diagnosed with uterine cervical squamous cell carcinoma with parametrium invasion and no other distant affected organs were detected. The cerebral lesion was surgically removed and pathologically proved to be metastasis of uterine cervical squamous cell carcinoma. The patient underwent concurrent chemoradiotherapy, followed by cerebral radiation therapy, but multiple metastases to the liver and lung developed and the patient died 7 months after diagnosis of brain metastasis.
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Yumi
authors: Y
authors: Sato
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Kei
authors: K
authors: Tanaka
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Yoichi
authors: Y
authors: Kobayashi
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Hiromi
authors: H
authors: Shibuya
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Yoshiko
authors: Y
authors: Nishigaya
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Mai
authors: M
authors: Momomura
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Hironori
authors: H
authors: Matsumoto
authors: Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors: Mitsutoshi
authors: M
authors: Iwashita
mesh_terms: D000647:Amnesia / Q000209:etiology; D000855:Anorexia / Q000209:etiology; D058070:Asymptomatic Diseases / Q000628:therapy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000556:secondary / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000503:physiopathology / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D057210:Delayed Diagnosis; D017809:Fatal Outcome; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000556:secondary / Q000628:therapy; D006261:Headache / Q000209:etiology; D006801:Humans; D007564:Japan; D008875:Middle Aged; D000077195:Squamous Cell Carcinoma of Head and Neck; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014717:Vertigo / Q000209:etiology; D014839:Vomiting / Q000209:etiology
keywords: brain metastasis; cervical cancer; chemotherapy; craniotomy; radiotherapy