title: Size Control in the Nanoprecipitation Process of Stable Iodine (¹²⁷I) Using Microchannel Reactor-Optimization by Artificial Neural Networks.
abstract: In this study, nanosuspension of stable iodine ((127)I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was evaluated by dynamic light scattering. The response surfaces obtained from ANNs model illustrated the determining effect of input variables (solvent and antisolvent flow rate, surfactant concentration, and solvent temperature) on the output variable (nanoparticle size). Comparing the 3D graphs revealed that solvent and antisolvent flow rate had reverse relation with size of nanoparticles. Also, those graphs indicated that the solvent temperature at low values had an indirect relation with size of stable iodine ((127)I) nanoparticles, while at the high values, a direct relation was observed. In addition, it was found that the effect of surfactant concentration on particle size in the nanosuspension of stable iodine ((127)I) was depended on the solvent temperature. Nanoprecipitation process of stable iodine (127I) and optimization of particle size using ANNs modeling.
authors: Faculty of Advanced Medical Technology, Golestan University of Medical Sciences, Gorgan, Iran.
authors: Mohamad Hosein
authors: MH
authors: Aghajani
authors: Department of Nanotechnology, The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
authors: Ali Mahmoud
authors: AM
authors: Pashazadeh
authors: Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.|Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Seyed Hossein
authors: SH
authors: Mostafavi
authors: Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
authors: Shayan
authors: S
authors: Abbasi
authors: Shohadaye Khalije Fars Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.
authors: Mohammad-Javad
authors: MJ
authors: Hajibagheri-Fard
authors: Department of Nanotechnology, The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
authors: Majid
authors: M
authors: Assadi
authors: Department of Nanotechnology, The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Institute, Bushehr University of Medical Sciences, Bushehr, Iran. m.aghajani@bpums.ac.ir.|Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. m.aghajani@bpums.ac.ir.
authors: Mahdi
authors: M
authors: Aghajani
mesh_terms: D011232:Chemical Precipitation; D000067493:Dynamic Light Scattering; D007456:Iodine Isotopes / Q000737:chemistry*; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D008956:Models, Chemical; D053758:Nanoparticles; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D016571:Neural Networks, Computer; D010316:Particle Size; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013696:Temperature
chemical_list: D007456:Iodine Isotopes; D012997:Solvents; D013501:Surface-Active Agents
keywords: ANNs; microfluidic; nanoprecipitation; particle size; stable iodine
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