title: [Prognostic role of human epidermal growth factor receptor 2 in resectable gastric cancer: a meta-analysis].
abstract: OBJECTIVE
  To investigate the prognostic association of human epidermal growth factor receptor 2 (HER-2) with resectable gastric cancer.
  
  
  METHODS
  The literature databases, such as PubMed, EMBASE, Cochrane Library, Web of Science, CBM,CNKI, and Wanfang database, were extensively searched to retrieve the clinical studies of HER-2 expression in resectable gastric cancer published before July, 2013. The association of HER-2 expression with overall survival(OS) was examined. The state 12.0 version software was used for meta-analysis. The quality of these studies were assessed using the Newcasthe-Ottawa scale.
  
  
  RESULTS
  There were nine studies meeting the inclusion criteria for meta-analysis including 4787 cases and the scores of all studies are more than 6 points. Meta-analysis showed no significant heterogeneity (I(2)=10.6%, P=0.347) among these studies. There was no significant difference in overall survival between positive HER-2 and negative HER-2 patients (HR=1.16, 95% CI:0.97-1.38, P=0.114).
  
  
  CONCLUSIONS
  HER-2 overexpression in the tumor is not identified as a significant prognostic factor in patients with resectable gastric cancer.
authors: Department of Gastrointestinal Surgery, The Second Hospital of Ningbo City, Zhejiang Ningbo 315010, China. nbchp@126.com.
authors: Hua
authors: H
authors: Ye
authors: Ping
authors: P
authors: Chen
authors: Qi
authors: Q
authors: Zheng
authors: Feng
authors: F
authors: Wu
authors: Cheng
authors: C
authors: Zheng
mesh_terms: D006801:Humans; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases; D013274:Stomach Neoplasms
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human