title: Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival.
abstract: Mutations in the mtDNA genome have long been suspected to play an important role in cancer. Although most cancer cells harbor mtDNA mutations, the question of whether such mutations are associated with clinical prognosis of lung cancer remains unclear. We resequenced the entire mitochondrial genomes of tumor tissue from a population of 250 Korean patients with non-small cell lung cancer (NSCLC). Our analysis revealed that the haplogroup (D/D4) was associated with worse overall survival (OS) of early-stage NSCLC [adjusted hazard ratio (AHR), 1.95; 95% CI, 1.14-3.33; P trend = 0.03]. By comparing the mtDNA variations between NSCLC tissues and matched blood samples, we found that haplogroups M/N and/or D/D4 were hotspots for somatic mutations, suggesting a more complicated mechanism of mtDNA somatic mutations other than the commonly accepted mechanism of sequential accumulation of mtDNA mutations.
authors: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors: Zhaoxi
authors: Z
authors: Wang
authors: Department of Thoracic Surgery, Samsung Medical Center, Seoul, Korea.
authors: Sojung
authors: S
authors: Choi
authors: Department of Thoracic Surgery, Samsung Medical Center, Seoul, Korea.
authors: Jinseon
authors: J
authors: Lee
authors: Brown University, Providence, RI, USA.
authors: Yen-Tsung
authors: YT
authors: Huang
authors: Nanjing Medical University, School of Public Health, Nanjing, China.
authors: Feng
authors: F
authors: Chen
authors: Nanjing Medical University, School of Public Health, Nanjing, China.
authors: Yang
authors: Y
authors: Zhao
authors: Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
authors: Xihong
authors: X
authors: Lin
authors: Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
authors: Donna
authors: D
authors: Neuberg
authors: Department of Thoracic Surgery, Samsung Medical Center, Seoul, Korea.
authors: Jhingook
authors: J
authors: Kim
authors: Department of Thoracic Surgery, Samsung Medical Center, Seoul, Korea.
authors: David C
authors: DC
authors: Christiani
keywords: haplogroup; lung cancer survival; mitochondria genome; mitochondria mutations; mitochondrial genome resequencing
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