title: The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients.
abstract: BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy controls were checked. BDNF levels were significantly lower in patients (F = 52.28, p < 0.0001), but the distribution of the SNP was not significantly different. Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not affect plasma BDNF levels in our participants. In heroin-dependent patients, plasma BDNF levels were negatively correlated with the length of heroin dependency. Long-term (>15 years) users had significantly lower plasma BDNF levels than did short-term (<5 years) users. We conclude that plasma BDNF concentration in habitual heroin users are not affected by BDNF Val66Met gene variants, but by the length of the heroin dependency.
authors: Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Shiou-Lan
authors: SL
authors: Chen
authors: Department of Psychiatry, Kaohsiung Veteran's General Hospital, Kaohsiung, Taiwan.
authors: Sheng-Yu
authors: SY
authors: Lee
authors: 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
authors: Yun-Hsuan
authors: YH
authors: Chang
authors: 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
authors: Tzu-Yun
authors: TY
authors: Wang
authors: Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA.
authors: Shih-Heng
authors: SH
authors: Chen
authors: Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA.
authors: Chun-Hsien
authors: CH
authors: Chu
authors: 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
authors: Po See
authors: PS
authors: Chen
authors: 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
authors: Yen Kuang
authors: YK
authors: Yang
authors: Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA.
authors: Jau-Shyong
authors: JS
authors: Hong
authors: 1] Institute of Behavioral Medicine, National Cheng Kung University, Taiwan, Taiwan [2] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [3] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan [4] Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan, Taiwan [5] Addiction Research Center, National Cheng Kung University, Taiwan, Taiwan [6] Center for Neuropsychiatric Research, National Health Research Institute, Tainan, Taiwan.
authors: Ru-Band
authors: RB
authors: Lu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D002681:China; D015536:Down-Regulation; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D003932:Heroin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D019966:Substance-Related Disorders / Q000235:genetics* / Q000473:pathology; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D003932:Heroin
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