title: Salutary Effects of Estrogen Sulfate for Traumatic Brain Injury.
abstract: Estrogen plays an important role as a neuroprotector in the central nervous system (CNS), directly interacting with neurons and regulating physiological properties of non-neuronal cells. Here we evaluated estrogen sulfate (E2-SO4) for traumatic brain injury (TBI) using a Sprague-Dawley rat model. TBI was induced via lateral fluid percussion (LFP) at 24 h after craniectomy. E2-SO4 (1 mg/kg BW in 1 mL/kg BW) or saline (served as control) was intravenously administered at 1 h after TBI (n=5/group). Intracranial pressure (ICP), cerebral perfusion pressure (CPP), and partial brain oxygen pressure (pbtO2) were measured for 2 h (from 23 to 25 h after E2-SO4 injection). Brain edema and diffuse axonal injury (DAI) were assessed by diffusion tensor imaging (DTI), and cerebral glycolysis was measured by (18)F-labeled fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging, at 1 and 7 days after E2-SO4 injection. E2-SO4 significantly decreased ICP, while increasing CPP and pbtO2 (p<0.05) as compared with vehicle-treated TBI rats. The edema size in the brains of the E2-SO4 treated group was also significantly smaller than that of vehicle-treated group at 1 day after E2-SO4 injection (p=0.04), and cerebral glycolysis of injured region was also increased significantly during the same time period (p=0.04). However, E2-SO4 treatment did not affect DAI (p>0.05). These findings demonstrated the potential benefits of E2-SO4 in TBI.
authors: 1 Department of Radiology, University of Alabama at Birmingham , Birmingham, Alabama.
authors: Hyunki
authors: H
authors: Kim
authors: 2 Department of Surgery, University of Alabama at Birmingham , Birmingham, Alabama.
authors: Betul
authors: B
authors: Cam-Etoz
authors: 1 Department of Radiology, University of Alabama at Birmingham , Birmingham, Alabama.
authors: Guihua
authors: G
authors: Zhai
authors: 2 Department of Surgery, University of Alabama at Birmingham , Birmingham, Alabama.
authors: William J
authors: WJ
authors: Hubbard
authors: 1 Department of Radiology, University of Alabama at Birmingham , Birmingham, Alabama.
authors: Kurt R
authors: KR
authors: Zinn
authors: 2 Department of Surgery, University of Alabama at Birmingham , Birmingham, Alabama.
authors: Irshad H
authors: IH
authors: Chaudry
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D020833:Diffuse Axonal Injury / Q000175:diagnosis / Q000188:drug therapy; D056324:Diffusion Tensor Imaging; D004195:Disease Models, Animal; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D019788:Fluorodeoxyglucose F18; D006019:Glycolysis / Q000187:drug effects*; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D004970:Estrone; C017296:estrone sulfate
keywords: DTI; PET; TBI; estrogen
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