title: A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities.
abstract: Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular gut symbionts for maintaining the health of their hosts. Here we performed a large structural survey of fecal microbiota in 314 healthy young adults, covering 20 rural and urban cohorts from 7 ethnic groups living in 9 provinces throughout China. Canonical analysis of unweighted UniFrac principal coordinates clustered the subjects mainly by their ethnicities/geography and less so by lifestyles. Nine predominant genera, all of which are known to contain short-chain fatty acid producers, co-occurred in all individuals and collectively represented nearly half of the total sequences. Interestingly, species-level compositional profiles within these nine genera still discriminated the subjects according to their ethnicities/geography and lifestyles. Therefore, a phylogenetically diverse core of gut microbiota at the genus level may be commonly shared by distinctive healthy populations as functionally indispensable ecosystem service providers for the hosts.
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Jiachao
authors: J
authors: Zhang
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
authors: Zhuang
authors: Z
authors: Guo
authors: State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
authors: Zhengsheng
authors: Z
authors: Xue
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Zhihong
authors: Z
authors: Sun
authors: State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
authors: Menghui
authors: M
authors: Zhang
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Lifeng
authors: L
authors: Wang
authors: State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
authors: Guoyang
authors: G
authors: Wang
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Fang
authors: F
authors: Wang
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Jie
authors: J
authors: Xu
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Hongfang
authors: H
authors: Cao
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Haiyan
authors: H
authors: Xu
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Qiang
authors: Q
authors: Lv
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Zhi
authors: Z
authors: Zhong
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Yongfu
authors: Y
authors: Chen
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Sudu
authors: S
authors: Qimuge
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Bilige
authors: B
authors: Menghe
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Yi
authors: Y
authors: Zheng
authors: 1] State Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China [2] Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Centre for Systems Biomedicine, Shanghai, China.
authors: Liping
authors: L
authors: Zhao
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
authors: Wei
authors: W
authors: Chen
authors: Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of P. R. China, Department of Food Science and Engineering, Inner Mongolia Agricultural University, Inner Mongolia, China.
authors: Heping
authors: H
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000235:genetics*; D002681:China; D016000:Cluster Analysis; D015331:Cohort Studies; D017753:Ecosystem; D005006:Ethnicity; D005232:Fatty Acids, Volatile / Q000737:chemistry; D005243:Feces; D005260:Female; D000069196:Gastrointestinal Microbiome; D005843:Geography; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008019:Life Style; D008297:Male; D064307:Microbiota / Q000235:genetics*; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D005232:Fatty Acids, Volatile; D012336:RNA, Ribosomal, 16S
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