title: Assigning cause for sudden unexpected infant death.
abstract: We have reached a conundrum in assigning cause of death for sudden unexpected infant deaths. We summarize the discordant perspectives and approaches and how they have occurred, and recommend a pathway toward improved consistency. This lack of consistency affects pediatricians and other health care professionals, scientific investigators, medical examiners and coroners, law enforcement agencies, families, and support or advocacy groups. We recommend that an interdisciplinary international committee be organized to review current approaches for assigning cause of death, and to identify a consensus strategy for improving consistency. This effort will need to encompass intrinsic risk factors or infant vulnerability in addition to known environmental risk factors including unsafe sleep settings, and must be sufficiently flexible to accommodate a progressively expanding knowledge base.
authors: Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814-4799, USA, carl.hunt@usuhs.edu.
authors: Carl E
authors: CE
authors: Hunt
authors: Robert A
authors: RA
authors: Darnall
authors: Betty L
authors: BL
authors: McEntire
authors: Bruce A
authors: BA
authors: Hyma
mesh_terms: D001237:Asphyxia / Q000175:diagnosis / Q000209:etiology; D001512:Bedding and Linens / Q000009:adverse effects; D001513:Beds / Q000009:adverse effects; D002423:Cause of Death; D053447:Channelopathies / Q000235:genetics; D032921:Consensus; D003937:Diagnosis, Differential; D005554:Forensic Medicine; D030342:Genetic Diseases, Inborn; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012307:Risk Factors; D012890:Sleep; D013398:Sudden Infant Death / Q000145:classification* / Q000175:diagnosis / Q000209:etiology*; D009626:Terminology as Topic
references: Heart Rhythm. 2010 Jun;7(6):779-80
references: 20176136
references: Int J Legal Med. 2010 Jul;124(4):301-6
references: 20198379
references: Pediatr Res. 2010 Nov;68(5):409-13
references: 20661167
references: Arch Dis Child. 2010 Dec;95(12):1009-12
references: 20880945
references: J Forensic Sci. 2011 Mar;56(2):415-7
references: 21265843
references: J Neuropathol Exp Neurol. 2011 Sep;70(9):799-810
references: 21865888
references: Cardiology. 2011;119(1):21-33
references: 21778721
references: Pediatrics. 2011 Nov;128(5):e1341-67
references: 22007003
references: Pediatrics. 2011 Nov;128(5):1030-9
references: 22007004
references: J Forensic Sci. 2012 Mar;57(2):364-9
references: 21981558
references: Pediatrics. 2012 Mar;129(3):e756-61
references: 22351881
references: Heart Rhythm. 2012 May;9(5):760-9
references: 22155597
references: Forensic Sci Med Pathol. 2012 Sep;8(3):312-5
references: 22076788
references: Am J Forensic Med Pathol. 2012 Sep;33(3):197-201
references: 21030849
references: J Forensic Leg Med. 2012 Nov;19(8):455-6
references: 23084308
references: Pediatr Res. 2013 Apr;73(4 Pt 2):570-6
references: 23314292
references: Biol Neonate. 1994;65(3-4):194-7
references: 8038282
references: Pediatrics. 1997 Oct;100(4):613-21
references: 9310514
references: J Mol Med (Berl). 2005 Aug;83(8):610-8
references: 15918042
references: Am J Epidemiol. 2006 Apr 15;163(8):762-9
references: 16582034
references: Int J Legal Med. 2006 Nov;120(6):331-6
references: 16237562
references: JAMA. 2006 Nov 1;296(17):2124-32
references: 17077377
references: Forensic Sci Int. 2007 Jan 17;165(2-3):129-43
references: 16806765
references: Am J Med Genet A. 2007 Apr 15;143A(8):771-88
references: 17340630
references: Acta Paediatr. 2008 Jul;97(7):861-5
references: 18477062
references: Pediatrics. 2009 Feb;123(2):533-9
references: 19171619
references: Acta Neuropathol. 2009 Mar;117(3):257-65
references: 19052756
references: Annu Rev Pathol. 2009;4:517-50
references: 19400695
references: J Pediatr. 2010 Jan;156(1):44-48.e1
references: 19772970
references: JAMA. 2010 Feb 3;303(5):430-7
references: 20124538
references: Acta Paediatr. 2010 Mar;99(3):384-8
references: 19958302
references: NCHS Data Brief. 2013 Apr;(120):1-8
references: 23759138
references: Respir Physiol Neurobiol. 2013 Nov 1;189(2):301-14
references: 23851109
references: Pediatr Res. 2014 Sep;76(3):220-9
references: 24964230
references: Neuropediatrics. 2002 Jun;33(3):142-9
references: 12200744
references: Semin Neonatol. 2003 Apr;8(2):159-67
references: 15001152
references: Pediatrics. 2004 Jul;114(1):234-8
references: 15231934
references: Pediatr Pathol. 1991 Sep-Oct;11(5):677-84
references: 1745639
references: Forensic Sci Med Pathol. 2009 Dec;5(4):254-60
references: 19484508