title: The past, present, and future of Leishmania genomics and transcriptomics.
abstract: It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite. Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite-host-vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to explore how disease in dogs relates to that in humans, and how an improved understanding in line with the 'One Health' concept may open new avenues for the control of these devastating diseases.
authors: Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. Electronic address: cc779@cam.ac.uk.
authors: Cinzia
authors: C
authors: Cantacessi
authors: Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz-PE, Brazil; Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Bari, Italy.
authors: Filipe
authors: F
authors: Dantas-Torres
authors: Royal Veterinary College, University of London, North Mymms, UK.
authors: Matthew J
authors: MJ
authors: Nolan
authors: Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Bari, Italy.
authors: Domenico
authors: D
authors: Otranto
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling / Q000639:trends*; D018503:Genome, Protozoan / Q000235:genetics; D023281:Genomics / Q000639:trends*; D006801:Humans; D007891:Leishmania / Q000235:genetics* / Q000378:metabolism*; D007896:Leishmaniasis / Q000517:prevention & control*; D059467:Transcriptome / Q000235:genetics
keywords: Leishmania infantum; One Health; bioinformatics; genome; high-throughput sequencing; host-parasite interactions; leishmaniases; metazoonosis; sand fly; transcriptome
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