title: Microparticles as potential biomarkers of cardiovascular disease.
abstract: Primary prevention of cardiovascular disease is a choice of great relevance because of its impact on health. Some biomarkers, such as microparticles derived from different cell populations, have been considered useful in the assessment of cardiovascular disease. Microparticles are released by the membrane structures of different cell types upon activation or apoptosis, and are present in the plasma of healthy individuals (in levels considered physiological) and in patients with different pathologies. Many studies have suggested an association between microparticles and different pathological conditions, mainly the relationship with the development of cardiovascular diseases. Moreover, the effects of different lipid-lowering therapies have been described in regard to measurement of microparticles. The studies are still controversial regarding the levels of microparticles that can be considered pathological. In addition, the methodologies used still vary, suggesting the need for standardization of the different protocols applied, aiming at using microparticles as biomarkers in clinical practice.
authors: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Carolina Nunes
authors: CN
authors: França
authors: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Maria Cristina de Oliveira
authors: MC
authors: Izar
authors: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Jônatas Bussador do
authors: JB
authors: Amaral
authors: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Daniela Melo
authors: DM
authors: Tegani
authors: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Francisco Antonio Helfenstein
authors: FA
authors: Fonseca
mesh_terms: D015415:Biomarkers; D001792:Blood Platelets / Q000473:pathology; D002318:Cardiovascular Diseases / Q000473:pathology*; D055252:Cell-Derived Microparticles / Q000473:pathology*; D003920:Diabetes Mellitus / Q000473:pathology; D042783:Endothelial Cells / Q000473:pathology; D004727:Endothelium / Q000473:pathology; D006801:Humans; D008488:Medical Illustration; D009000:Monocytes / Q000473:pathology
chemical_list: D015415:Biomarkers
references: Blood. 2011 Aug 25;118(8):2366-74
references: 21700772
references: Cardiovasc Res. 2005 Jul 1;67(1):30-8
references: 15878159
references: J Hum Hypertens. 2002 Aug;16(8):539-47
references: 12149659
references: J Am Coll Cardiol. 2005 May 17;45(10):1622-30
references: 15893178
references: J Hum Hypertens. 2005 Jul;19(7):551-7
references: 15829999
references: J Am Coll Cardiol. 2013 Oct 15;62(16):1436-41
references: 23707318
references: Diab Vasc Dis Res. 2013 Jul;10(4):368-74
references: 23673378
references: Thromb Haemost. 2003 Mar;89(3):486-92
references: 12624632
references: Diabetes Res Clin Pract. 2005 Jun;68(3):193-201
references: 15936460
references: J Thromb Haemost. 2011 Sep;9(9):1870-3
references: 21707910
references: J Hum Hypertens. 2007 Jan;21(1):38-44
references: 17051237
references: Br J Haematol. 2014 Aug;166(4):571-80
references: 24766273
references: Br J Haematol. 2003 Dec;123(5):896-902
references: 14632781
references: Am J Obstet Gynecol. 2002 Aug;187(2):450-6
references: 12193942
references: Thromb Haemost. 2008 Oct;100(4):663-9
references: 18841290
references: Diabetes Res Clin Pract. 2006 Sep;73(3):241-8
references: 16584800
references: Blood. 2004 Nov 1;104(9):2761-6
references: 15242875
references: Blood. 2000 Feb 1;95(3):930-5
references: 10648405
references: Braz J Med Biol Res. 2014 May;47(5):432-7
references: 24760119
references: J Cell Mol Med. 2010 Sep;14(9):2250-6
references: 20597998
references: Thromb Haemost. 2001 Apr;85(4):639-46
references: 11341498
references: Circulation. 2001 Nov 27;104(22):2649-52
references: 11723013
references: Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1910-5
references: 15072974
references: Thromb Res. 2006;117(4):385-92
references: 15896827
references: Circ J. 2012;76(3):729-36
references: 22214900
references: J Exp Med. 1996 Mar 1;183(3):1161-72
references: 8642258
references: Am Heart J. 2003 Jun;145(6):962-70
references: 12796750
references: Atherosclerosis. 2009 Jun;204(2):636-41
references: 19091315
references: Cell Biochem Biophys. 2014 Sep;70(1):687-96
references: 24777811
references: J Cell Mol Med. 2012 Nov;16(11):2777-88
references: 22697268
references: PLoS One. 2014;9(3):e91597
references: 24646764
references: Circ Res. 2014 Jan 3;114(1):109-13
references: 24141170
references: Int J Cardiol. 2012 Jun 28;158(1):125-9
references: 22569318
references: J Am Coll Cardiol. 2008 Oct 14;52(16):1302-11
references: 18929241
references: Br J Haematol. 2004 Feb;124(3):376-84
references: 14717787
references: J Thromb Haemost. 2003 Jan;1(1):171-7
references: 12871555
references: J Thromb Thrombolysis. 2011 Feb;31(2):173-9
references: 20680403
references: Atherosclerosis. 2010 Jan;208(1):264-9
references: 19674745
references: Biochim Biophys Acta. 2014 Feb;1842(2):202-7
references: 24275556
references: Biomed Res Int. 2014;2014:173401
references: 25061601
references: J Thromb Haemost. 2006 Mar;4(3):566-73
references: 16405517
references: FASEB J. 2007 Sep;21(11):2735-41
references: 17428963
references: J Immunol. 2008 Apr 1;180(7):5028-35
references: 18354228
references: Psychosomatics. 2014 May-Jun;55(3):252-60
references: 24374086
references: Thromb Haemost. 2002 Sep;88(3):415-20
references: 12353069
references: Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H871-7
references: 22886414
references: Thromb Haemost. 2001 May;85(5):810-20
references: 11372673
references: Circulation. 2000 Feb 29;101(8):841-3
references: 10694520
references: Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1106-14
references: 15879485
references: Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):27-33
references: 21160065
references: Int J Cardiol. 2013 Aug 10;167(3):936-42
references: 22465347
references: CNS Neurol Disord Drug Targets. 2012 Nov 1;11(7):921-5
references: 23131157
references: Eur Heart J. 2012 Dec;33(23):2928-38
references: 22453653
references: Am J Blood Res. 2013 May 05;3(2):107-23
references: 23675563
references: Platelets. 2008 Aug;19(5):365-72
references: 18791943
references: Cardiovasc Res. 2004 Aug 1;63(2):226-35
references: 15249180
references: Hypertension. 2003 Feb;41(2):211-7
references: 12574084
references: PLoS One. 2012;7(10):e46822
references: 23056467
references: Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1004-9
references: 15706036
references: Semin Oncol. 2014 Jun;41(3):346-58
references: 25023350
references: Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R467-76
references: 18046016
references: Mediators Inflamm. 2010;2010:250476
references: 20634911