title: Long-term effects of intratympanic methylprednisolone perfusion treatment on intractable Ménière's disease.
abstract: OBJECTIVE
  This study aimed to investigate the long-term efficacy of intratympanic methylprednisolone perfusion treatment for intractable Ménière's disease.
  
  
  METHODS
  A retrospective analysis of 17 intractable Ménière's disease patients treated with intratympanic methylprednisolone perfusion was performed. Treatment efficacy was evaluated according to the American Academy of Otolaryngology-Head and Neck Surgery criteria. Short and long-term control or improvement rates were calculated after 6 and 24 months, respectively.
  
  
  RESULTS
  Sixteen patients were followed for more than two years. Short- and long-term vertigo control rates were 94 per cent and 81 per cent, respectively; short- and long-term functional activity improvements were 94 per cent and 88 per cent, respectively. The pure tone average was 53 ± 14 dB before treatment, and 50 ± 16 dB at 6 months and 52 ± 20 dB at 24 months after intratympanic methylprednisolone perfusion. Tinnitus was controlled or improved in five patients over the two-year follow-up period.
  
  
  CONCLUSIONS
  Intratympanic methylprednisolone perfusion can effectively control vertigo and improve functional activity in intractable Ménière's disease patients with good hearing preservation. It may therefore be a viable alternative treatment for intractable Ménière's disease.
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: W
authors: W
authors: She
authors: Department of Otolaryngology-Head and Neck Surgery,Huai'an First People's Hospital,Nanjing Medical University,Jiangsu,China.
authors: L
authors: L
authors: Lv
authors: Hough Ear Institute,Oklahoma City,Oklahoma,USA.
authors: X
authors: X
authors: Du
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: H
authors: H
authors: Li
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: Y
authors: Y
authors: Dai
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: L
authors: L
authors: Lu
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: X
authors: X
authors: Ma
authors: Department of Otolaryngology-Head and Neck Surgery,Nanjing Drum Tower Hospital of Nanjing University Medical School,Jiangsu,China.
authors: F
authors: F
authors: Chen
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D000069555:Injection, Intratympanic; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: Tympanum