title: Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment.
abstract: Diabetes mellitus (DM), non-alcoholic fatty liver (NAFL), and obesity are associated with elevated branched-chain amino acid (BCAA) levels, but the mechanism and significance of this has not been elucidated. Eighty-four subjects were enrolled including 43 with DM. Serum BCAA levels were positively correlated with waist-hip ratio and ALT. Serum BCAA levels in subjects with DM were higher than non-DM and those in subjects with NAFL were also higher than non-NAFL. Treatment with pioglitazone and alogliptin (19 of 43 DM subjects) improved serum haemoglobin A1c and decreased BCAA levels. The decrease in BCAAs with improved glucose metabolism suggests that abnormal glucose metabolism is also a factor in elevated BCAA levels.
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan. Electronic address: motoh@clin.medic.mie-u.ac.jp.
authors: Motoh
authors: M
authors: Iwasa
authors: Department of Gastroenterology and Hepatology, Yokkaichi Digestive Disease Center, Yokkaichi, Japan.
authors: Tomoaki
authors: T
authors: Ishihara
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
authors: Rumi
authors: R
authors: Mifuji-Moroka
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
authors: Naoki
authors: N
authors: Fujita
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
authors: Yoshinao
authors: Y
authors: Kobayashi
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
authors: Hiroshi
authors: H
authors: Hasegawa
authors: Nutrition Unit, Mie University Hospital, Tsu, Japan.
authors: Kazuko
authors: K
authors: Iwata
authors: Mie Shokakinaika, Tsu, Japan.
authors: Masahiko
authors: M
authors: Kaito
authors: Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
authors: Yoshiyuki
authors: Y
authors: Takei
mesh_terms: D000368:Aged; D000597:Amino Acids, Branched-Chain / Q000037:antagonists & inhibitors / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D007564:Japan; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D009765:Obesity / Q000150:complications; D000077205:Pioglitazone; D010880:Piperidines / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000627:therapeutic use; D014463:Ultrasonography; D015854:Up-Regulation / Q000187:drug effects*; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D049629:Waist-Hip Ratio
chemical_list: D000597:Amino Acids, Branched-Chain; D015415:Biomarkers; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000077205:Pioglitazone; D010880:Piperidines; D045162:Thiazolidinediones; D014498:Uracil; C517652:hemoglobin A1c protein, human; C520853:alogliptin
keywords: Antidiabetic drug; Branched-chain amino acid; Diabetes mellitus; Non-alcoholic fatty liver; Obesity