title: Combination therapy of ursodeoxycholic acid and budesonide for PBC-AIH overlap syndrome: a meta-analysis.
abstract: In this study, a meta-analysis of randomized controlled trials comparing ursodeoxycholic acid (UDCA) monotherapy with combination therapies utilizing UDCA and budesonide was performed. We found that combination therapy with UDCA and budesonide was more effective than UDCA monotherapy for primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Moreover, compared to prednisone, budesonide has fewer side effects.
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors: Huawei
authors: H
authors: Zhang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Jing
authors: J
authors: Yang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Clinical Medical College of Nanjing Medical University, Nanjing, People's Republic of China.
authors: Rong
authors: R
authors: Zhu
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Yuanyuan
authors: Y
authors: Zheng
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors: Yuqing
authors: Y
authors: Zhou
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Weiqi
authors: W
authors: Dai
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Fan
authors: F
authors: Wang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Kan
authors: K
authors: Chen
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Jingjing
authors: J
authors: Li
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Chengfen
authors: C
authors: Wang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Sainan
authors: S
authors: Li
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Tong
authors: T
authors: Liu
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Huerxidan
authors: H
authors: Abudumijiti
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Clinical Medical College of Nanjing Medical University, Nanjing, People's Republic of China.
authors: Zheng
authors: Z
authors: Zhou
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Clinical Medical College of Nanjing Medical University, Nanjing, People's Republic of China.
authors: Jianrong
authors: J
authors: Wang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China ; The First Clinical Medical College of Nanjing Medical University, Nanjing, People's Republic of China.
authors: Wenxia
authors: W
authors: Lu
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Junshan
authors: J
authors: Wang
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Yujing
authors: Y
authors: Xia
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Yingqun
authors: Y
authors: Zhou
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Jie
authors: J
authors: Lu
authors: Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
authors: Chuanyong
authors: C
authors: Guo
mesh_terms: D019819:Budesonide / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002756:Cholagogues and Choleretics / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D016017:Odds Ratio; D016032:Randomized Controlled Trials as Topic; D013577:Syndrome; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D005938:Glucocorticoids; D019819:Budesonide; D014580:Ursodeoxycholic Acid
keywords: PBC–AIH overlap syndrome; UDCA; budesonide; combination therapy; meta-analysis
references: Baillieres Best Pract Res Clin Gastroenterol. 2000 Aug;14(4):615-28
references: 10976018
references: Am J Gastroenterol. 2002 May;97(5):1191-7
references: 12014727
references: Gastroenterol Res Pract. 2013;2013:236963
references: 23653636
references: Neth J Med. 2012 Oct;70(8):349-56
references: 23065982
references: Clin Gastroenterol Hepatol. 2014 May;12(5):863-9
references: 24076417
references: Hepatology. 2010 Jun;51(6):2193-213
references: 20513004
references: J Gastroenterol Hepatol. 2010 Feb;25(2):376-82
references: 19817953
references: World J Gastroenterol. 2008 Jun 7;14(21):3368-73
references: 18528934
references: Hepatol Res. 2011 Sep;41(9):877-86
references: 21883738
references: Eur J Intern Med. 2012 Dec;23(8):e193-8
references: 23022449
references: Am J Gastroenterol. 2010 Feb;105(2):345-53
references: 19888204
references: Drug Des Devel Ther. 2014;8:1277-86
references: 25246769
references: Autoimmun Rev. 2012 Mar;11(5):330-4
references: 22001521
references: J Hepatol. 2009 Aug;51(2):237-67
references: 19501929
references: Am J Gastroenterol. 2009 Jun;104(6):1420-5
references: 19491855
references: Hepatology. 1998 Aug;28(2):360-5
references: 9695997
references: World J Gastroenterol. 2006 Mar 7;12(9):1362-6
references: 16552802
references: Hepatology. 2002 Feb;35(2):409-13
references: 11826416
references: J Hepatol. 2006 Feb;44(2):400-6
references: 16356577
references: Control Clin Trials. 1996 Feb;17(1):1-12
references: 8721797
references: Chin Med J (Engl). 2006 Feb 5;119(3):238-41
references: 16537013
references: Ann Intern Med. 2001 Dec 4;135(11):982-9
references: 11730399
references: Gastroenterol Clin Biol. 2007 Jan;31(1):17-25
references: 17273128
references: Zhonghua Gan Zang Bing Za Zhi. 2011 May;19(5):334-9
references: 21645439
references: Hepatogastroenterology. 2010 May-Jun;57(99-100):441-6
references: 20698205
references: Hepatology. 1998 Aug;28(2):296-301
references: 9695990
references: Gastroenterol Clin North Am. 2008 Jun;37(2):461-78, vii-viii
references: 18499031
references: Hepatogastroenterology. 2002 Sep-Oct;49(47):1195-200
references: 12239904