title: Database of Gene Co-Regulation (dGCR): A Web Tool for Analysing Patterns of Gene Co-regulation across Publicly Available Expression Data.
abstract: The database of Gene Co-Regulation (dGCR) is a web tool for the analysis of gene relationships based on correlated patterns of gene expression over publicly available transcriptional data. The motivation behind dGCR is that genes whose expression patterns correlate across many experiments tend to be co-regulated and hence share biological function. In addition to revealing functional connections between individual gene pairs, extended sets of co-regulated genes can also be assessed for enrichment of gene ontology classes and interaction pathways. This functionality provides an insight into the biological function of the query gene itself. The dGCR web tool extends the range of expression data curated by existing co-regulation databases and provides additional insights into gene function through the analysis of pathways, gene ontology classes and co-regulation modules.
authors: Wolfson Centre for Age-Related Diseases, King's College London, London Bridge, London SE1 1UL, UK.
authors: Gareth
authors: G
authors: Williams
keywords: Global gene expression; connectivity map; microarray.
references: Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
references: 16199517
references: Nature. 2007 Jan 11;445(7124):168-76
references: 17151600
references: Nucleic Acids Res. 2011 Jan;39(Database issue):D1002-4
references: 21071405
references: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D535-9
references: 16381927
references: Cancer Cell. 2006 Oct;10(4):331-42
references: 17010674
references: Nat Chem Biol. 2012 Dec;8(12 ):999-1007
references: 23103940
references: Nucleic Acids Res. 2013 Jan;41(Database issue):D1014-20
references: 23203868
references: Genome Biol. 2009;10(11):R130
references: 19919682
references: BMC Genomics. 2013 Nov 07;14:765
references: 24199845
references: Bioinformatics. 2011 Jun 15;27(12):1739-40
references: 21546393
references: Nucleic Acids Res. 2007 Jan;35(Database issue):D760-5
references: 17099226
references: BMC Genomics. 2012 Jan 10;13:12
references: 22233519
references: Bioinformatics. 2011 Dec 1;27(23 ):3317-8
references: 21967760
references: J Cell Biol. 2003 Nov 10;163(3):463-8
references: 14610053
references: Nucleic Acids Res. 2012 Jan;40(Database issue):D1077-81
references: 22064864
references: BMC Genomics. 2012 Oct 06;13:535
references: 23039964
references: Science. 2006 Sep 29;313(5795):1929-35
references: 17008526
references: Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367 (1607):3264-75
references: 23108545
references: Genome Res. 2009 Nov;19(11):1953-62
references: 19797678
references: Genome Biol. 2003;4(4):R28
references: 12702209
references: Nat Genet. 2000 May;25(1):25-9
references: 10802651
references: BMC Genomics. 2009 Sep 03;10:411
references: 19728865