title: Aptamers as a novel tool for diagnostics and therapy.
abstract: Aptamers are short single-stranded DNA or RNA oligonucleotides that are capable of binding small molecules, proteins, or nucleotides with high specificity. They show a stable conformation and high binding affinity for their target molecules. There are numerous applications for aptamers in biotechnology, molecular diagnostics and targeted therapy of diseases. Their production is cheap, and they generally display lower immunogenicity than monoclonal antibodies. In the present review, we give an introduction to the preparation of aptamers and provide examples for their use in biotechnology, diagnostics and therapy of diseases.
authors: Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
authors: Onat
authors: O
authors: Kadioglu
authors: Anna Helena
authors: AH
authors: Malczyk
authors: Henry Johannes
authors: HJ
authors: Greten
authors: Thomas
authors: T
authors: Efferth
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015415:Biomarkers; D035843:Biomedical Research / Q000379:methods*; D000067470:Cellular Reprogramming Techniques; D002846:Chromatography, Affinity; D004277:DNA, Single-Stranded; D019937:Diagnostic Techniques and Procedures; D015723:Gene Library; D006801:Humans; D015813:Substance Abuse Detection
chemical_list: D052157:Aptamers, Nucleotide; D015415:Biomarkers; D004277:DNA, Single-Stranded
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