title: Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.
abstract: Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
authors: Tyson J
authors: TJ
authors: Moyer
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors: Hussein A
authors: HA
authors: Kassam
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors: Edward S M
authors: ES
authors: Bahnson
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors: Courtney E
authors: CE
authors: Morgan
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
authors: Faifan
authors: F
authors: Tantakitti
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors: Teng L
authors: TL
authors: Chew
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
authors: Melina R
authors: MR
authors: Kibbe
authors: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.|Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.|Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.|Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.
authors: Samuel I
authors: SI
authors: Stupp
mesh_terms: D000818:Animals; D020212:Carotid Artery Injuries / Q000188:drug therapy* / Q000473:pathology; D046911:Macromolecular Substances; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D046911:Macromolecular Substances; D010455:Peptides; D013501:Surface-Active Agents
keywords: peptides; self-assembly; supramolecular chemistry; vascular targeting
references: Nat Nanotechnol. 2007 Apr;2(4):249-55
references: 18654271
references: Angew Chem Int Ed Engl. 2011 Apr 4;50(15):3421-4
references: 21413108
references: Soft Matter. 2012 Jan 1;8(25):2689-2692
references: 22707978
references: Nature. 2010 Apr 15;464(7291):1067-70
references: 20305636
references: Biopolymers. 2010;94(1):1-18
references: 20091874
references: Sci Transl Med. 2012 Apr 4;4(128):128ra39
references: 22491949
references: Nano Lett. 2009 Mar;9(3):945-51
references: 19193022
references: Stroke. 2005 Feb;36(2):367-73
references: 15625299
references: Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1235-40
references: 20080552
references: Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19347-52
references: 22087004
references: Nat Biotechnol. 2008 Jan;26(1):83-90
references: 18157119
references: ACS Nano. 2012 Sep 25;6(9):7956-65
references: 22928955
references: J Vasc Surg. 2008 Jan;47(1):173-82
references: 18178471
references: Cancer Res. 2004 Nov 1;64(21):7668-72
references: 15520166
references: Nitric Oxide. 2011 Jun 30;25(1):22-30
references: 21554972
references: Science. 2001 Nov 23;294(5547):1684-8
references: 11721046
references: ACS Nano. 2011 Nov 22;5(11):9113-21
references: 22044255
references: Chem Commun (Camb). 2012 Jan 4;48(1):26-33
references: 22080255
references: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2213-8
references: 20133865
references: Angew Chem Int Ed Engl. 2009;48(32):5946-9
references: 19582745
references: Exp Biol Med (Maywood). 2007 Oct;232(9):1121-9
references: 17895520
references: J Am Chem Soc. 2010 Jul 7;132(26):8819-21
references: 20552966
references: JAMA. 2005 Jan 12;293(2):165-71
references: 15644543
references: Pharm Res. 2009 Jan;26(1):235-43
references: 18712584
references: J Control Release. 2010 Sep 1;146(2):196-200
references: 20385181
references: Circulation. 1998 Oct 20;98(16):1657-65
references: 9778332
references: Adv Drug Deliv Rev. 2009 Sep 30;61(11):931-9
references: 19596034