title: Polymorphic CAG Repeat and Protein Expression of Androgen Receptor Gene in Colorectal Cancer.
abstract: Although somatic alterations in CAG repeats in the androgen receptor (AR) gene have been suggested to predispose to colorectal cancer, less is known about AR in colorectal cancer carcinogenesis. Because of lack of relevant analysis on CAG repeat length and AR expression in colorectal cancer, we aimed to investigate the prognostic value of polymorphic CAG and protein expression of the AR gene in patients with colorectal cancer. A case-control study was carried out on 550 patients with colorectal cancer and 540 healthy controls to investigate whether polymorphic CAG within the AR gene is linked to increased risk for colorectal cancer. Polymorphic CAG and AR expression were analyzed to clarify their relationship with clinicopathologic and prognostic factors in patients with colorectal cancer. The study showed that the AR gene in patients with colorectal cancer had a longer CAG repeat sequence than those in the control group, as well as increased risk for colorectal cancer among females (P = 0.013), males (P = 0.002), and total colorectal cancer population (P < 0.001), respectively. AR expression exhibited a significant difference in long CAG repeat sequence among males (P < 0.001), females (P < 0.001), and total colorectal cancer study population (P < 0.001). Both long CAG repeat sequence and negative AR expression were associated with a short 5-year overall survival (OS) rate in colorectal cancer. Long CAG repeat sequences and the absence of AR expression were closely related to the development of colorectal cancer. Both long CAG and decreased AR expression were correlated with the poor 5-year OS in patients with colorectal cancer.
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Rui
authors: R
authors: Huang
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Guiyu
authors: G
authors: Wang
authors: Department of Tumor Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Yanni
authors: Y
authors: Song
authors: Department of General Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
authors: Feng
authors: F
authors: Wang
authors: Department of General Surgery, Affiliated Liaoyang Central Hospital of China Medical University, Liaoyang, China.
authors: Bing
authors: B
authors: Zhu
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Qingchao
authors: Q
authors: Tang
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Zheng
authors: Z
authors: Liu
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Yinggang
authors: Y
authors: Chen
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Qian
authors: Q
authors: Zhang
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Shan
authors: S
authors: Muhammad
authors: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Colorectal Cancer Institute, Harbin Medical University, Harbin, China. xishan1208@126.com.
authors: Xishan
authors: X
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D011379:Prognosis; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism*; D019680:Trinucleotide Repeat Expansion; D018911:Trinucleotide Repeats; D047368:Tumor Burden
chemical_list: D011944:Receptors, Androgen