title: Clinical associations between metabolic syndrome and the development of microalbuminuria in Korean men.
abstract: OBJECTIVE
  There have been several studies on the association between metabolic syndrome (MetS) and microalbuminuria. However, none has examined whether MetS is associated with the prospective development of microalbuminuria. Accordingly, we performed a prospective study to evaluate the longitudinal effects of baseline number of MetS traits on the development of microalbuminuria in Korean men.
  
  
  METHODS
  1649 Korean men without microalbuminuria in 2005 were included and followed prospectively until 2010 with the endpoint being the development of microalbuminuria. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Microalbuminuria was evaluated by urine albumin creatinine ratio (UACR). Risk estimations for development of microalbuminuria were analyzed according to the number of MetS traits using multivariate adjusted Cox proportional hazards model.
  
  
  RESULTS
  During 5611.8 person-years of follow-up (median 3.40±1.46 years), microalbuminuria developed in 91 (5.5%) participants between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for development of microalbuminuria comparing 1, 2 and 3-5 MetS traits vs 0 were 2.57 (0.97-6.82), 2.94 (1.09-7.98) and 3.85 (1.37-10.86), respectively.
  
  
  CONCLUSIONS
  The number of MetS traits independently associated with the future development of microalbuminuria during the 5-year follow-up period, and MetS per se was an independent risk factor for microalbuminuria.
authors: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors: Jae-Hong
authors: JH
authors: Ryoo
authors: Health Promotion Center, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors: Hyejin
authors: H
authors: Chun
authors: Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors: Hong-Soo
authors: HS
authors: Lee
authors: Department of Family Medicine, CHAUM, CHA University School of Medicine, Pocheon, Republic of Korea.
authors: Eunkyung
authors: E
authors: Suh
authors: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors: Joong-Myung
authors: JM
authors: Choi
authors: Department of Occupational and Environmental Medicine, Dongguk University, Gyeongju Hospital, Seoul, Republic of Korea.
authors: Min-Gi
authors: MG
authors: Kim
authors: Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors: HoCheol
authors: H
authors: Shin
authors: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea; Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. Electronic address: kkkmin7@hotmail.com.
authors: Sung Keun
authors: SK
authors: Park
authors: Korea Institute of Drug Safety and Risk Management, Seoul, Republic of Korea.
authors: Chang-Mo
authors: CM
authors: Oh
authors: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Taeg Su
authors: TS
authors: Ko
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000150:complications / Q000453:epidemiology*; D044466:Asian People; D015331:Cohort Studies; D003920:Diabetes Mellitus; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D016016:Proportional Hazards Models; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
keywords: Metabolic syndrome; Microalbuminuria; Urine albumin creatinine ratio