title: Decreased ARID1A expression correlates with poor prognosis of clear cell renal cell carcinoma.
abstract: Clear cell renal cell carcinoma (CCRCC) is the most common renal cell carcinoma. It has a relatively unfavorable prognosis compared to other common renal cell carcinomas. Recently, comprehensive molecular studies in CCRCC revealed important genetic alterations, including changes in the VHL, PBRM1, and ARID1A genes. The expression of ARID1A protein is associated with tumor progression and prognosis in many cancers. This study aimed to evaluate the nuclear expression of ARID1A in CCRCC and to assess its expression with the clinical prognosis. The nuclear expression of ARID1A was evaluated in 290 cases of CCRCC by immunohistochemistry. To determine the clinicopathological association with ARID1A, each of the cases was divided into 2 groups, low- and high-expression groups, according to the average proportion of nuclear staining. Decreased ARID1A expression was associated with the higher nuclear grade and higher pTNM stage (P < .001 and P = .013, respectively). The ARID1A low-expression group revealed significantly shorter cancer-specific and progression-free survival times (P = .001 and P < .001, respectively). Furthermore, Cox regression analysis showed that ARID1A expression was an independent prognostic factor for progression-free survival (P = .009). These results suggest that nuclear expression of ARID1A may serve as a new prognostic marker in CCRCC patients.
authors: Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799.
authors: Jeong Hwan
authors: JH
authors: Park
authors: Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799.
authors: Cheol
authors: C
authors: Lee
authors: Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799.
authors: Ja Hee
authors: JH
authors: Suh
authors: Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799.
authors: Ji Yoen
authors: JY
authors: Chae
authors: Department of Pathology, Good Moonhwa Hospital, Busan, Republic of Korea, 601-803.
authors: Hwal Woong
authors: HW
authors: Kim
authors: Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799; Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799. Electronic address: blue7270@snu.ac.kr.
authors: Kyung Chul
authors: KC
authors: Moon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry; D002648:Child; D004268:DNA-Binding Proteins; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D013534:Survival; D014157:Transcription Factors / Q000032:analysis*; D055815:Young Adult
chemical_list: C112476:ARID1A protein, human; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors
keywords: ARID1A; Clear cell renal cell carcinoma; Immunohistochemistry; Prognosis; Progression