title: Xanthenones: calixarenes-catalyzed syntheses, anticancer activity and QSAR studies.
abstract: An efficient method is proposed for obtaining tetrahydrobenzo[a]xanthene-11-ones and tetrahydro-[1,3]-dioxolo[4,5-b]xanthen-9-ones. The method is based on the use of p-sulfonic acid calix[n]arenes as catalysts under solvent-free conditions. The antiproliferative activity of fifty-nine xanthenones against six human cancer cells was studied. The capacity of all compounds to inhibit cancer cell growth was dependent on the histological origin of the cells. QSAR studies indicate that among compounds derived from β-naphthol the most efficient compounds against glioma (U251) and renal (NCI-H460) cancer cells are those having higher hydrogen bonding donor ability.
authors: Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. adefatima@qui.ufmg.br.
authors: Daniel Leite
authors: DL
authors: da Silva
authors: Bruna
authors: B
authors: Silva Terra
authors: Mateus
authors: M
authors: Ribeiro Lage
authors: Ana Lúcia Tasca Góis
authors: AL
authors: Ruiz
authors: Cameron
authors: C
authors: Capeletti da Silva
authors: João Ernesto
authors: JE
authors: de Carvalho
authors: José
authors: J
authors: Walkimar de Mesquita Carneiro
authors: Felipe
authors: F
authors: Terra Martins
authors: Sergio Antonio
authors: SA
authors: Fernades
authors: Ângelo
authors: Â
authors: de Fátima
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047250:Calixarenes / Q000737:chemistry*; D002384:Catalysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D014966:Xanthenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014966:Xanthenes; D047250:Calixarenes