title: Recoupling of right and left ventricle pump function after surgical ventricle restoration: a cardiac magnetic resonance study.
abstract: To evaluate biventricular pump function after surgical ventricle restoration (SVR) using cardiac magnetic resonance (CMR). We retrospectively studied 39 patients who performed 1.5-T CMR before/after SVR acquiring short-axis ECG-gated cine sequences. End-diastolic, end-systolic, and stroke volume indexed to body surface area (EDVI, ESVI, and SVI), ejection fraction (EF), and their modification after SVR (∆) were obtained for right ventricle (RV) and left ventricle (LV). Wilcoxon signed rank test and Spearman correlation coefficient were used; EF reproducibility was estimated. Median LVEF increased from 24% [interquartile range (IQR) 19-31%] before SVR to 34% (IQR 29-43%) after SVR (P < 0.001). Median RVEF remained unchanged from 58% (IQR 48-66%) before SVR to 57% (IR 46-64%) after SVR (P = 0.743). The correlation between LVEF and RVEF was not significant before SVR (r = 0.182; P = 0.266) but significant after SVR (r = 0.445; P = 0.005). The ∆RVEF was positively correlated with ∆LVEF (r = 0.558; P < 0.001). ∆RVSVI was positively correlated with ∆LVSVI (r = 0.502; P = 0.001). LVEF reproducibility before SVR was 97% for both intra- and inter-reader reproducibility; RVEF reproducibility was 96 and 93%, respectively. SVR improved LV function without apparent impact on RV function. After SVR the two ventricles showed a functional recoupling. Reproducibility of CMR EF was excellent for both ventricles.
authors: Unità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan, 20097, San Donato Milanese, Milano, Italy, francesco.secchi@grupposandonato.it.
authors: Francesco
authors: F
authors: Secchi
authors: Marcello
authors: M
authors: Petrini
authors: Giovanni
authors: G
authors: Di Leo
authors: Francesco
authors: F
authors: Bandera
authors: Serenella
authors: S
authors: Castelvecchio
authors: Marco
authors: M
authors: Guazzi
authors: Lorenzo
authors: L
authors: Menicanti
authors: Francesco
authors: F
authors: Sardanelli
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures; D055424:Cardiac-Gated Imaging Techniques; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D015588:Observer Variation; D011237:Predictive Value of Tests; D020127:Recovery of Function; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D020257:Ventricular Remodeling
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