title: Epidemiological trends of histopathologically WHO classified CNS tumors in developing countries: systematic review.
abstract: BACKGROUND
  Many developing countries are lagging behind in reporting epidemiological data for individual central nervous system (CNS) tumors. This paper aimed to elicit patterns for the epidemiology of individual World Health Organization (WHO) classified CNS tumors in countries registered by WHO as "developing".
  
  
  METHODS
  Cyber search was carried out through 66 cancer networks/registries and 181 PubMed published papers that reported counts of CNS tumors for the period of 2009-2012. The relationship between the natural log of incidence Age Standardized Rate (ASR) reported by Globocan and Latitude/ Longitude was investigated.
  
  
  RESULTS
  Registries for 21 countries displayed information related to CNS tumors. In contrast tends for classified CNS tumor cases were identified for 38 countries via 181 PubMed publications. Extracted data showed a majority of unclassified reported cases [PubMed (38 countries, 45.7%), registries (21 countries, 96.1%)]. For classified tumors, astrocytic tumors were the most frequently reported type [PubMed (38 countries, 1,245 cases, 15.7%), registries (21 countries, 627 cases, 1.99%]. A significant linear regression relationship emerged between latitudes and reported cases of CNS tumors.
  
  
  CONCLUSIONS
  Previously unreported trends of frequencies for individually classified CNS tumors were elucidated and a possible link of CNS tumors occurrence with geographical location emerged.
authors: Center of Excellence in Genomic Medicine, King Abdulaziz University, Jeddah, Saudi Arabia E-mail : deemah@hotmail.com.
authors: Ishaq
authors: I
authors: Khan
authors: Mohammed
authors: M
authors: Bangash
authors: Saleh
authors: S
authors: Baeesa
authors: Awatif
authors: A
authors: Jamal
authors: Angel
authors: A
authors: Carracedo
authors: Fahad
authors: F
authors: Alghamdi
authors: Hanadi
authors: H
authors: Qashqari
authors: Adel
authors: A
authors: Abuzenadah
authors: Mohammed
authors: M
authors: AlQahtani
authors: Ghazi
authors: G
authors: Damanhouri
authors: Adeel
authors: A
authors: Chaudhary
authors: Deema
authors: D
authors: Hussein
mesh_terms: D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D003906:Developing Countries; D006801:Humans; D012042:Registries; D014944:World Health Organization