title: Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors.
abstract: Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered) navigation is quite preserved during aging, allocentric (externally-centered) navigation-based on a cognitive map using distant landmarks-declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Gregory
authors: G
authors: Beaudet
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Valentine
authors: V
authors: Bouet
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Christelle
authors: C
authors: Jozet-Alves
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Pascale
authors: P
authors: Schumann-Bard
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: François
authors: F
authors: Dauphin
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Eleni
authors: E
authors: Paizanis
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Michel
authors: M
authors: Boulouard
authors: Université de Caen Basse-Normandie, Groupe Mémoire et Plasticité Comportementale (GMPc), EA 4259 Caen, France.
authors: Thomas
authors: T
authors: Freret
keywords: 5-HT7R; Alzheimer’s disease; aging; serotonin; spatial cognition
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