title: Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors.
abstract: Mammalian lymphoid immunity is mediated by fast and slow responders to pathogens. Fast innate lymphocytes are active within hours after infections in mucosal tissues. Slow adaptive lymphocytes are conventional T and B cells with clonal antigen receptors that function days after pathogen exposure. A transcription factor (TF) regulatory network guiding early T cell development is at the core of effector function diversification in all innate lymphocytes, and the kinetics of immune responses is set by developmental programming. Operational units within the innate lymphoid system are not classified by the types of pathogen-sensing machineries but rather by discrete effector functions programmed by regulatory TF networks. Based on the evolutionary history of TFs of the regulatory networks, fast effectors likely arose earlier in the evolution of animals to fortify body barriers, and in mammals they often develop in fetal ontogeny prior to the establishment of fully competent adaptive immunity.
authors: Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655; email: joonsoo.kang@umassmed.edu.
authors: Joonsoo
authors: J
authors: Kang
authors: Nidhi
authors: N
authors: Malhotra
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate / Q000502:physiology*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D038041:Lymphopoiesis; D011485:Protein Binding / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
keywords: T cells; cytokines; evolution of immunity; fetal lymphopoiesis; transcription factor regulatory network; γδ T cells
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