title: Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
abstract: Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.
authors: CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.
authors: Denise
authors: D
authors: Bechet
authors: IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.
authors: Florent
authors: F
authors: Auger
authors: LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.
authors: Pierre
authors: P
authors: Couleaud
authors: Private executive, Marcilly-sur-Eure, France.
authors: Eric
authors: E
authors: Marty
authors: IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.
authors: Laura
authors: L
authors: Ravasi
authors: IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.
authors: Nicolas
authors: N
authors: Durieux
authors: Laboratoire d'Anatomopathologie, CHU, Vandœuvre-lès-Nancy.
authors: Corinne
authors: C
authors: Bonnet
authors: CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France; Laboratoire d'Anatomopathologie, CHU, Vandœuvre-lès-Nancy.
authors: François
authors: F
authors: Plénat
authors: LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.
authors: Céline
authors: C
authors: Frochot
authors: INSERM U1189, Lille University Hospital, Lille.
authors: Serge
authors: S
authors: Mordon
authors: ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.
authors: Olivier
authors: O
authors: Tillement
authors: LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy, France.
authors: Régis
authors: R
authors: Vanderesse
authors: ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.
authors: François
authors: F
authors: Lux
authors: ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.
authors: Pascal
authors: P
authors: Perriat
authors: CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.
authors: François
authors: F
authors: Guillemin
authors: CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France. Electronic address: muriel.barberi@univ-lorraine.fr.
authors: Muriel
authors: M
authors: Barberi-Heyob
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D018810:Magnetic Resonance Angiography; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D039942:Neuropilin-1 / Q000737:chemistry / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011859:Radiography; D051381:Rats; D011923:Rats, Nude
chemical_list: D017319:Photosensitizing Agents; D039942:Neuropilin-1
keywords: Brain tumor; Multifunctional nanoplatforms; Real-time MRI; Targeting; iPDT