title: Interleukin-27 in T cell immunity.
abstract: Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism.
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yunyan-todai@umin.ac.jp.
authors: Yukiko
authors: Y
authors: Iwasaki
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. kfujio-tky@umin.ac.jp.
authors: Keishi
authors: K
authors: Fujio
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tomohisa-tky@umin.ac.jp.
authors: Tomohisa
authors: T
authors: Okamura
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yamamoto-tky@umin.ac.jp.
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D064094:Interleukin-27 / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D015778:Minor Histocompatibility Antigens; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: C097732:EBI3 protein, human; D064094:Interleukin-27; D007378:Interleukins; D015778:Minor Histocompatibility Antigens; D050791:STAT Transcription Factors; D016753:Interleukin-10
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