title: Evaluation of Exalenz Bioscience's BreathID for Helicobacter pylori detection.
abstract: Carbon-labeled urea breath tests, which have high sensitivity and specificity, are the preferred method used in epidemiological studies, screening dyspeptic patients and assessing eradication or recurrence of Helicobacter pylori infection. The principle of the (13)C-urea breath test relies upon the ability of the H. pylori urease to hydrolyze the orally administered (13)C-urea. The BreathID (Exalenz Bioscience Inc., Union, NJ, USA) provides a competitive solution for breath testing, including unique features such as automatic continuous breath collection and analysis. This is an unattended convenient test, with no human error as the correct part of the breath is collected and patients' assistance is not required. The test results are available in real time at the point of care and enable shortened breath testing procedures. Additionally, several studies showing expanded utility of the BreathID in pediatrics, after therapy and during proton pump inhibitors intake, further support the safety and performance of the BreathID in the diagnosis of H. pylori.
authors: The Kamila Gonczarowski, Institute of Gastroenterology, Assaf Harofeh Medical Center, Zerifin, 70300 Israel.
authors: Efrat
authors: E
authors: Broide
authors: Haim
authors: H
authors: Shirin
mesh_terms: D057205:Automation, Laboratory; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods*; D002247:Carbon Isotopes; D005746:Gastric Emptying; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000201:enzymology*; D006801:Humans; D019095:Point-of-Care Systems; D012680:Sensitivity and Specificity; D013997:Time Factors; D014508:Urea / Q000378:metabolism*; D014510:Urease / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D014508:Urea; D014510:Urease
keywords: BreathID®; Helicobacter pylori; gastric emptying; test substrate; urea breath test