title: Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages.
abstract: METHODS
  Acute kidney injury (AKI) is the most frequent and serious complication in sepsis, a potentially deadly inflammatory response induced by bacterial, viral, or fungal infection. LPS-induced AKI is associated with an abnormal inflammatory response, including renal endothelial dysfunction and renal inflammation. Resveratrol, a natural phytoalexin with low toxicity and anti-inflammatory properties, is known to protect endothelial cells and modulate the immune response in sepsis.
  
  
  RESULTS
  This study investigates the potential protective effects of resveratrol on AKI induced by LPS exposure of mice. Resveratrol was administered as a pre- and posttreatment, or as a posttreatment alone following LPS injection and compared to control groups. Resveratrol significantly improved kidney function and lowered serum and kidney tissue inflammatory cytokine levels. Consistently, resveratrol prevented endotoxin-induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue. Resveratrol treatment attenuated the effects of LPS on macrophages, with significant inhibition of activation, cytokine release, and Toll-like receptor 4 activation. Resveratrol treatment also resulted in decreased expression of iNOS, Bcl-2, and Bcl-xL in macrophages, which was linked with induction of apoptosis in macrophages.
  
  
  CONCLUSIONS
  Our studies suggest that resveratrol might represent a novel therapeutic agent to prevent and treat sepsis-induced AKI.
authors: Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
authors: Liang
authors: L
authors: Chen
authors: Sixing
authors: S
authors: Yang
authors: Elizabeth E
authors: EE
authors: Zumbrun
authors: Hongbing
authors: H
authors: Guan
authors: Prakash S
authors: PS
authors: Nagarkatti
authors: Mitzi
authors: M
authors: Nagarkatti
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D007249:Inflammation / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000502:physiology; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D051197:Toll-Like Receptor 4 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D016328:NF-kappa B; D013267:Stilbenes; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D000077185:Resveratrol
keywords: AKI; Kidney injury; LPS; Macrophage; Resveratrol
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