title: Evaluation of the Value of d-Dimer, P-Selectin, and Platelet Count for Prediction of Portal Vein Thrombosis After Devascularization.
abstract: OBJECTIVE
  To evaluate the value of d-dimer, P-selectin, and platelet count in patients with cirrhotic portal hypertension (PHT) for prediction of portal vein thrombosis (PVT) after devascularization.
  
  
  METHODS
  A total of 137 patients with cirrhotic PHT who undergone devascularization from January 2012 to April 2014 were retrospectively reviewed, all of them were divided into 2 groups (PVT group and non-PVT group) by Doppler ultrasonography (DU) examination. The level of d-dimer, P-selectin, and platelet count was tested during the perioperative period.
  
  
  RESULTS
  In all, 38 (27.7%) patients were found to have PVT by DU examination postoperatively. In contrast to the non-PVT group, the level of d-dimer, P-selectin, and platelet count in the PVT group was much higher significantly at 1, 3, and 7 days after devascularization. (P < .05). However, in the 15 days after surgery, the difference in P-selectin between the 2 groups was not significant (P = .260). It was shown that the highest sensitivity of the 3 markers for PVT was d-dimer, the highest specificity belonged to P-selectin. The area under receiver-operating characteristic (ROC) curve of P-selectin was the biggest of the 3 markers. When the 3 markers were combined to be used to diagnose PVT, the sensitivity was increased to 0.907, with a slight drop of specificity to 0.693, the area under the ROC curve was 0.927.
  
  
  CONCLUSIONS
  The level of d-dimer, P-selectin, and platelet count might be good candidate predictive markers for PVT in patients with cirrhotic PHT after devascularization. The combined test of the 3 markers can increase the value of prediction.
authors: Department of General Surgery, the 81st Hospital of P.L.A., P.L.A. Cancer Center, Nanjing, China.
authors: Yang
authors: Y
authors: Fei
authors: Department of General Surgery, the 81st Hospital of P.L.A., P.L.A. Cancer Center, Nanjing, China fei_yanggood@163.com.
authors: Guang-Quan
authors: GQ
authors: Zong
authors: Department of General Surgery, the 81st Hospital of P.L.A., P.L.A. Cancer Center, Nanjing, China.
authors: Jian
authors: J
authors: Chen
authors: Department of General Surgery, the 81st Hospital of P.L.A., P.L.A. Cancer Center, Nanjing, China.
authors: Ren-Min
authors: RM
authors: Liu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005355:Fibrosis; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010976:Platelet Count; D011169:Portal Vein; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; C036309:fibrin fragment D
keywords: P-selectin; d-dimer; devascularization; platelet count; portal vein thrombosis