title: The role of flavonoids on oxidative stress in epilepsy.
abstract: BACKGROUND
  Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABAA-receptor resulting in anticonvulsive effects.
  
  
  OBJECTIVE
  This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed.
  
  
  CONCLUSIONS
  There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.
authors: Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil.
authors: Tâmara Coimbra
authors: TC
authors: Diniz
authors: Department of Physiology, Federal University of Sergipe, 49100-000 São Cristóvão, SE, Brazil.
authors: Juliane Cabral
authors: JC
authors: Silva
authors: Federal University of Pernambuco, 50740-521 Recife, PE, Brazil.
authors: Sarah Raquel Gomes
authors: SR
authors: de Lima-Saraiva
authors: Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil.
authors: Fernanda Pires Rodrigues de Almeida
authors: FP
authors: Ribeiro
authors: Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil.
authors: Alessandra Gomes Marques
authors: AG
authors: Pacheco
authors: Federal University of Piauí, 64049-550 Teresina, PI, Brazil.
authors: Rivelilson Mendes
authors: RM
authors: de Freitas
authors: Department of Physiology, Federal University of Sergipe, 49100-000 São Cristóvão, SE, Brazil.
authors: Lucindo José
authors: LJ
authors: Quintans-Júnior
authors: Department of Physiology, Federal University of Sergipe, 49100-000 São Cristóvão, SE, Brazil.
authors: Jullyana de Souza Siqueira
authors: Jde S
authors: Quintans
authors: Federal University of San Francisco Valley, 56304-205 Petrolina, PE, Brazil.
authors: Rosemairy Luciane
authors: RL
authors: Mendes
authors: Postgraduate Program in Biotechnology, State University of Feira de Santana, 44036-900 Feira de Santana, BA, Brazil ; Federal University of San Francisco Valley, 56304-205 Petrolina, PE, Brazil.
authors: Jackson Roberto Guedes da Silva
authors: JR
authors: Almeida
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005419:Flavonoids / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D005419:Flavonoids; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A
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