title: Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule.
abstract: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a distinct entity from systemic ALCL (sALCL). sALCL usually shows immunohistochemical positivity for anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA), whereas these tests are negative in pcALCL. In contrast to sALCL, pcALCL is rarely found in children and young adults. We present here a case of a rare clinical condition in a 21-year-old woman, who has pcALCL with positive ALK and patchy EMA expression. She experiences a large, rapidly growing nodule without any outside-nodule manifestation. In conclusion, both ALK and EMA expression alone cannot distinguish pcALCL from secondary skin involvement by a sALCL.
authors: Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Dan
authors: D
authors: Xue
authors: Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Xiuzhen
authors: X
authors: Li
authors: Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors: Yunqing
authors: Y
authors: Ren
authors: City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
authors: Qi
authors: Q
authors: Liu
authors: City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
authors: Yun
authors: Y
authors: Yen
authors: City of Hope Comprehensive Cancer Center, Duarte, CA, USA lxue@coh.org.
authors: Lijun
authors: L
authors: Xue
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000378:metabolism / Q000473:pathology*; D018396:Mucin-1 / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: anaplastic lymphoma kinase; epithelial membrane antigen; primary cutaneous anaplastic large cell lymphoma; systemic anaplastic large cell lymphoma