title: Response to tocilizumab in rheumatoid arthritis is not influenced by the body mass index of the patient.
abstract: OBJECTIVE
  To assess the relationship between the body mass index (BMI) and the efficacy of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA).
  
  
  METHODS
  We conducted a retrospective study in 222 patients with RA followed by 5 centers. The European League Against Rheumatism response was evaluated at 6 months. Univariate and multivariate logistic regressions were performed.
  
  
  RESULTS
  No significant association between the BMI and the response to TCZ at 6 months was found after adjustment for potential confounding factors (adjusted OR 0.45, 95% CI 0.16-1.24, p = 0.13 and OR 1.19, 95% CI 0.31-4.48, p = 0.78 for BMI 25-30 kg/m(2) and BMI > 30 kg/m(2), respectively, compared to BMI < 25 kg/m(2)).
  
  
  CONCLUSIONS
  Response to TCZ in patients with RA is not influenced by the baseline BMI, in contrast to anti-tumor necrosis factor drugs.
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital. ympers2000@yahoo.fr.
authors: Yves-Marie
authors: YM
authors: Pers
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Marie
authors: M
authors: Godfrin-Valnet
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Joseph
authors: J
authors: Lambert
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Clémentine
authors: C
authors: Fortunet
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Elodie
authors: E
authors: Constant
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Thibault
authors: T
authors: Mura
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Béatrice
authors: B
authors: Pallot-Prades
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Christian
authors: C
authors: Jorgensen
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Jean-Francis
authors: JF
authors: Maillefert
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Hubert
authors: H
authors: Marotte
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Daniel
authors: D
authors: Wendling
authors: From the Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; INSERM CIC 1001, Arnaud de Villeneuve University Hospital, Montpellier; Rheumatology, Besançon University Teaching Hospital, Besançon; Rheumatology Unit, Grenoble University Hospital, Grenoble; Rheumatology, Dijon University Hospital, Dijon; Rheumatology Unit, Saint-Étienne University Hospital, Saint-Étienne, France.Y-M. Pers, MD; C. Jorgensen, MD, PhD, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital; M. Godfrin-Valnet, MD; D. Wendling, MD, PhD, Rheumatology, Besançon University Teaching Hospital; J. Lambert, MD; P. Gaudin, MD, PhD, Rheumatology Unit, Grenoble University Hospital; C. Fortunet, MD; J-F. Maillefert, MD, PhD, Rheumatology, Dijon University Hospital; E. Constant, MD; B. Pallot-Prades, MD; H. Marotte, MD, PhD, Rheumatology Unit, Saint-Etienne University Hospital; T. Mura, MD, PhD, INSERM CIC 1001, Arnaud de Villeneuve University Hospital.
authors: Philippe
authors: P
authors: Gaudin
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; C502936:tocilizumab
keywords: BODY MASS INDEX; RESPONSE; RHEUMATOID ARTHRITIS; TOCILIZUMAB