title: Multifrequency time-harmonic elastography for the measurement of liver viscoelasticity in large tissue windows.
abstract: Elastography of the liver for the non-invasive diagnosis of hepatic fibrosis is an established method. However, investigations of obese patients or patients with ascites are often limited by small and superficial elastographic windows. Therefore, multifrequency time-harmonic elastography (THE) based on time-resolved A-line ultrasound has recently been developed for measuring liver viscoelasticity in wide soft tissue windows and at greater depths. In this study, THE was integrated into a clinical B-mode scanner connected to a dedicated actuator bed driven by superimposed vibrations of 30- to 60-Hz frequencies. The resulting shear waves in the liver were captured along multiple profiles 7 to 14 cm in width and automatically processed for reconstruction of mean efficient shear wave speed and shear wave dispersion slope. This new modality was tested in healthy volunteers and 22 patients with clinically proven cirrhosis. Patients could be separated from controls by higher shear wave speeds (3.11 ± 0.64 m/s, 2.14-4.81 m/s, vs. 1.74 ± 0.10 m/s, 1.60-1.91 m/s) without significant degradation of data by high body mass index or ascites. Furthermore, the wave speed dispersion slope was significantly (p = 0.0025) lower in controls (5.2 ± 1.8 m/s/kHz) than in patients (39.1 ± 32.2 m/s/kHz). In conclusion, THE is useful for the diagnosis of cirrhosis in large tissue windows.
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Heiko
authors: H
authors: Tzschätzsch
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Selcan
authors: S
authors: Ipek-Ugay
authors: GAMPT mbH, Merseburg, Germany.
authors: Manh Nguyen
authors: MN
authors: Trong
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Jing
authors: J
authors: Guo
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Jonathan
authors: J
authors: Eggers
authors: Clinic for Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Enno
authors: E
authors: Gentz
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Thomas
authors: T
authors: Fischer
authors: GAMPT mbH, Merseburg, Germany.
authors: Michael
authors: M
authors: Schultz
authors: Institute of Medical Informatics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Jürgen
authors: J
authors: Braun
authors: Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: ingolf.sack@charite.de.
authors: Ingolf
authors: I
authors: Sack
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001201:Ascites / Q000150:complications; D015992:Body Mass Index; D016022:Case-Control Studies; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging / Q000502:physiology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications
keywords: Ascites; Liver cirrhosis; Multifrequency vibrations; Obesity; Shear wave speed dispersion; Time-harmonic elastography