title: Disrupted resting-state functional connectivity and its changing trend in migraine suffers.
abstract: Chronic pain has been linked with learning and memory processes and functional changes in brain plasticity in its development and maintenance via neuroimaging studies. However, the principle of reorganization of the migraine brain network as the brain progresses into chronic pain remain poorly understood. Here, using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory approaches, we aimed to investigate the dynamic dysfunctional connectivity in 108 patients with migraine without aura (MWoA) and 30 gender-matched healthy controls (HC). All patients were divided into 40 groups using a sliding boxcar grouping of subjects in disease duration order. As compared with HC, nonparametric permutation tests were applied for between-group comparisons of functional connectivity strength in each patient group. We focused only on the between-group differences of functional connections in MWoA, and the situation how these different connections were organized along with the changing trend. As the disease duration increased, the presence of chronic headache altered the functional connectivity from the local central nervous system (CNS) to a disruption in the whole-brain networks. These dysfunctional connections integrated into a connected component in relatively longer migraine duration groups, suggesting an abnormal integrated network configuration with ongoing central changes for long-term migraine. Within these between-group differences of the connected component, there were contained a small number of brain regions that had disproportionately numerous connections. Moreover, these brain regions exhibited a tendency to link to each other were organized into a strongly interconnected community. These interconnected brain regions were mainly located in the sensory-discriminative brain areas. Our results exhibited a working model of the central mechanisms of migraine where the brain functional connectivity was altered from the local central nervous system to a densely interconnected center, which may extend our understanding of the role of learning mechanisms which are likely involved in maintenance of chronic pain.
authors: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China.
authors: Jixin
authors: J
authors: Liu
authors: Ling
authors: L
authors: Zhao
authors: Fangfei
authors: F
authors: Lei
authors: Yi
authors: Y
authors: Zhang
authors: Kai
authors: K
authors: Yuan
authors: Qiyong
authors: Q
authors: Gong
authors: Fanrong
authors: F
authors: Liang
authors: Jie
authors: J
authors: Tian
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020326:Migraine without Aura / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009473:Neuronal Plasticity; D012146:Rest; D012815:Signal Processing, Computer-Assisted; D018709:Statistics, Nonparametric; D013997:Time Factors
keywords: brain network development; functional magnetic resonance imaging; migraine; the sensory-discriminative brain regions
references: J Neurophysiol. 1999 Oct;82(4):1934-43
references: 10515983
references: Neurosci Lett. 2012 Jun 29;520(2):197-203
references: 22579823
references: Neuroimage. 2010 May 1;50(4):1497-510
references: 20083210
references: Nat Rev Neurosci. 2009 Mar;10(3):186-98
references: 19190637
references: Curr Opin Neurol. 2010 Aug;23(4):341-50
references: 20581686
references: J Neurosci. 2007 Mar 28;27(13):3388-94
references: 17392455
references: Prog Neurobiol. 2009 Feb;87(2):81-97
references: 18952143
references: JAMA Psychiatry. 2013 Aug;70(8):783-92
references: 23739835
references: Cereb Cortex. 2000 Mar;10(3):220-42
references: 10731218
references: Annu Rev Clin Psychol. 2011;7:113-40
references: 21128784
references: J Pain. 2013 Dec;14(12):1703-8
references: 24290450
references: J Neurosci. 2012 Oct 24;32(43):14874-84
references: 23100410
references: BMC Musculoskelet Disord. 2008 Jun 28;9:97
references: 18588702
references: Neuroimage. 2011 Jan 15;54(2):1262-79
references: 20850551
references: PLoS One. 2011;6(10):e26010
references: 22022493
references: Chaos. 2009 Mar;19(1):015117
references: 19335021
references: Proc Natl Acad Sci U S A. 2011 May 3;108(18):7641-6
references: 21502525
references: Biol Psychiatry. 2013 Mar 1;73(5):472-81
references: 22537793
references: JAMA. 2004 Jan 28;291(4):493-4
references: 14747508
references: J Neurophysiol. 2009 Feb;101(2):875-87
references: 19073802
references: Hum Brain Mapp. 2009 May;30(5):1511-23
references: 18649353
references: Nat Rev Neurol. 2009 Apr;5(4):199-209
references: 19347025
references: Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19066-71
references: 22065778
references: Front Syst Neurosci. 2013 Feb 04;6:80
references: 23382713
references: Schizophr Bull. 2014 Mar;40(2):438-48
references: 24298172
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Neuron. 2010 Jan 28;65(2):280-90
references: 20152133
references: PLoS Biol. 2008 Jul 1;6(7):e159
references: 18597554
references: Front Syst Neurosci. 2010 Jun 17;4:22
references: 20592949
references: Ann N Y Acad Sci. 2011 Apr;1225:72-82
references: 21534994
references: Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11372-7
references: 22711833
references: Pain. 2011 Mar;152(3 Suppl):S49-S64
references: 21146929
references: Headache. 2008 Jul;48(7):1044-55
references: 18479421
references: Neuroimage. 2008 Nov 15;43(3):528-39
references: 18786642
references: Exp Neurol. 2013 Oct;248:196-204
references: 23648629
references: IEEE Trans Med Imaging. 1999 Jan;18(1):32-42
references: 10193695
references: J Neurosci. 2011 Nov 2;31(44):15775-86
references: 22049421
references: J Neurosci. 2006 Jan 4;26(1):63-72
references: 16399673
references: J Neurosci. 2012 Mar 21;32(12):4307-18
references: 22442092
references: Lancet Neurol. 2009 Jun;8(6):560-8
references: 19446275
references: Mol Interv. 2002 Oct;2(6):392-403, 339
references: 14993415
references: Curr Opin Neurol. 2013 Aug;26(4):353-9
references: 23757264
references: PLoS Comput Biol. 2009 May;5(5):e1000381
references: 19412534
references: J Neurosci. 2011 Jun 1;31(22):8259-70
references: 21632947
references: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references: 17274684
references: PLoS One. 2012;7(12):e51250
references: 23227257
references: JAMA. 2012 Nov 14;308(18):1889-97
references: 23150008
references: Curr Biol. 2009 Jun 23;19(12):1023-7
references: 19427210
references: Neurol Sci. 2010 Jun;31 Suppl 1:S19-22
references: 20464577
references: PLoS One. 2011;6(11):e27049
references: 22073251
references: Neuroimage. 2012 Feb 1;59(3):2142-54
references: 22019881
references: Ann N Y Acad Sci. 2011 Apr;1224:109-125
references: 21251014
references: Neuroimage. 2010 Apr 1;50(2):499-508
references: 20026219
references: PLoS Biol. 2005 May;3(5):e141
references: 15819609
references: Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17558-63
references: 19805061