title: Multiple malignancies in a female patient with common variable immunodeficiency syndrome.
abstract: We herein present the case of a 55-year-old woman with a previous history of malignancies--uterine adenocarcinoma, basal cell carcinoma (which occurred twice consecutively), recurrent respiratory infections due to common variable immunodeficiency (CVID), and systemic granulomatous disease diagnosed at a later age. The patient suffered from diffuse large B cell lymphoma (DLBCL), which was successfully treated with R-CHOP chemotherapy, and continued with immunoglobulin supplementation. The patient was free of lymphoma and infectious complications for over 20 months despite her persistent immunodeficiency, but eventually developed colorectal adenocarcinoma. To the best of our knowledge, this is the first reported case of CVID associated with multiple solid tumours and DLBCL.
authors: Clinic for Hematology, Clinical Center of Serbia, 11000 Belgrade, Serbia. bb.lena@gmail.com.
authors: Milena
authors: M
authors: Todorovic
authors: Bela
authors: B
authors: Balint
authors: Bosko
authors: B
authors: Andjelic
authors: Biljana
authors: B
authors: Mihaljevic
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology; D002280:Basal Cell Carcinoma / Q000209:etiology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D012141:Respiratory Tract Infections / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology; D014594:Uterine Neoplasms / Q000209:etiology
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