title: Socioeconomic status is independently associated with overall survival in patients with multiple myeloma.
abstract: Population-based studies suggest that black patients with multiple myeloma (MM) have a higher mortality rate than white patients. However, other studies suggest that this disparity is related to socioeconomic status (SES) rather than race. To provide clarity on this topic, we reviewed 562 patients diagnosed with MM at our institution. Patients with high SES had a median overall survival (OS) of 62.8 months (95% confidence interval [CI] 43.1-82.6 months), compared to 53.7 months (45.2-62.3 months) and 48.6 months (40.4-56.8 months) for middle and low SES, respectively (p = 0.015). After controlling for race, age, year of diagnosis, severity of comorbidities, stem cell transplant utilization and insurance provider, patients with low SES had a 54% increase in mortality rate relative to patients with high SES. To support our findings, we performed a similar analysis of 45,505 patients with MM from the Surveillance, Epidemiology and End Results-18 (SEER) database. Low SES is independently associated with poorer OS in MM.
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Mark A
authors: MA
authors: Fiala
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Joseph D
authors: JD
authors: Finney
authors: b Division of Biostatistics, Department of Medicine , Washington University School of Medicine , St. Louis , MO , USA.
authors: Jingxia
authors: J
authors: Liu
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Keith E
authors: KE
authors: Stockerl-Goldstein
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Michael H
authors: MH
authors: Tomasson
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Ravi
authors: R
authors: Vij
authors: a Division of Oncology , Washington University School of Medicine , St. Louis , MO , USA.
authors: Tanya M
authors: TM
authors: Wildes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D054625:Healthcare Disparities; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007348:Insurance, Health; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009101:Multiple Myeloma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D011159:Population Surveillance; D012042:Registries; D012189:Retrospective Studies; D018426:SEER Program; D012923:Social Class; D014481:United States / Q000453:epidemiology
keywords: Multiple myeloma; cancer health disparities; race; socioeconomic status
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