title: Monitoring the spreading stage of lung cells by silicon nanowire electrical cell impedance sensor for cancer detection purposes.
abstract: We developed a silicon nanowire based electrical cell impedance sensor (SiNW-ECIS) as an instrument that detects cancerous cultured living lung cells by monitoring their spreading state at which the cells stretched and become extended on nanowires. Further current penetration into the extended membrane of malignant cells in respect to normal ones (In the first 6h after cells interaction with surface) are the key mechanism in our diagnosis procedure. The developed device applied to monitor the spreading-induced electrical differences between cancerous and normal lung cells in an integral fashion. Detection was performed so faster than the time required to complete cells mitosis. Morphology and architecture of doped Si nanowires covered microelectrodes observably enhance the contact area between cells and electrodes which support accurate signal recording from stretched cells as indicated by SEM and florescent images.
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Hamed
authors: H
authors: Abiri
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.
authors: Mohammad
authors: M
authors: Abdolahad
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Milad
authors: M
authors: Gharooni
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Seyed
authors: S
authors: Ali Hosseini
authors: Medical Nanotechnology and Tissue Engineering Research Center, Shahid-Beheshti University of Medical Sciences P.O. Box 1985717443, Tehran, Iran.
authors: Mohsen
authors: M
authors: Janmaleki
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Soheil
authors: S
authors: Azimi
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Mohammad
authors: M
authors: Hosseini
authors: Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
authors: Shams
authors: S
authors: Mohajerzadeh
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D017097:Electric Impedance; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D053770:Nanowires / Q000737:chemistry; D012825:Silicon / Q000737:chemistry
chemical_list: D012825:Silicon
keywords: Biosensor; Cancer diagnosis; Cell spreading; Current penetration; Impedance; SiNW-ECIS