title: Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population.
abstract: BACKGROUND
  The EHF and ELF5 genes, located on chromosome 11p and linked to asthma phenotypes, are high-potential candidate genes conferring asthma susceptibility. The purpose of this study was to investigate the genetic association among single nucleotide polymorphisms (SNPs) of EHF and ELF5, and their relationship with asthma in the Taiwanese population.
  
  
  METHODS
  We selected and performed genotyping on 16 SNPs that encompass the genomic region of EHF and ELF5 in Taiwanese children with or without asthma. A total of 1983 children, 523 in the test group and 619 and 842 in two validation groups, were recruited for this study.
  
  
  RESULTS
  The SNP rs3910901, located in the 5' upstream region of ELF5, was found to have a weak association (p = 0.043) with asthma in the odds ratio analysis. The genotype distribution was similar in all comparison groups, but the CC genotype was more frequent in asthma patients. Logistic regression adjusted allergy comorbidity showed obviously diluted association.
  
  
  CONCLUSIONS
  The results indicated that SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.
authors: Department of Pediatrics and Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
authors: Jiu-Yao
authors: JY
authors: Wang
authors: Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
authors: Shyh-Dar
authors: SD
authors: Shyur
authors: Division of Research Development, Vita Genomics Inc., Taipei, Taiwan.
authors: Frada Wei-Sam
authors: FW
authors: Lam
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: lshwu@mail.tcu.edu.tw.
authors: Lawrence Shih-Hsin
authors: LS
authors: Wu
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C403306:EHF protein, human; C116038:ELF5 protein, human; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors
keywords: EHF; ELF5; genetic polymorphism; pediatric asthma