title: Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults.
abstract: Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measured by divergent thinking (VCDT) and novelty seeking based on prior studies suggesting associations between these and dopaminergic functions. We examined this issue in a large sample of right-handed healthy young adults. We used analyses of MD and a psychological measure of VCDT, as well as personality measures of the Temperament and Character Inventory (TCI). Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus. Furthermore, not only higher novelty seeking, but also lower harm avoidance, higher self-directedness, and higher self-transcendence were robustly associated with lower MD in the right globus pallidus, whereas higher persistence was associated with lower MD in the left globus pallidus. These personality variables were also associated with VCDT. The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. These results suggested the MD in the globus pallidus, underlie the association between VCDT and multiple personalities in TCI including novelty seeking.
authors: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors: Hikaru
authors: H
authors: Takeuchi
authors: Yasuyuki
authors: Y
authors: Taki
authors: Atsushi
authors: A
authors: Sekiguchi
authors: Hiroshi
authors: H
authors: Hashizume
authors: Rui
authors: R
authors: Nouchi
authors: Yuko
authors: Y
authors: Sassa
authors: Yuka
authors: Y
authors: Kotozaki
authors: Carlos Makoto
authors: CM
authors: Miyauchi
authors: Ryoichi
authors: R
authors: Yokoyama
authors: Kunio
authors: K
authors: Iizuka
authors: Seishu
authors: S
authors: Nakagawa
authors: Tomomi
authors: T
authors: Nagase
authors: Keiko
authors: K
authors: Kunitoki
authors: Ryuta
authors: R
authors: Kawashima
mesh_terms: D003405:Creativity; D005260:Female; D005917:Globus Pallidus / Q000033:anatomy & histology*; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D017711:Nonlinear Dynamics; D010555:Personality Inventory; D010556:Personality Tests; D011594:Psychometrics; D012044:Regression Analysis; D012737:Sex Factors; D013694:Temperament; D013850:Thinking; D055815:Young Adult
keywords: creativity; divergent thinking; dopamine; harm avoidance; mean diffusivity; novelty seeking
references: Front Behav Neurosci. 2013 Oct 02;7:133
references: 24106465
references: Neurosci Lett. 2001 Mar 2;300(1):59-61
references: 11172939
references: Neuroimage. 2009 Jan 1;44(1):83-98
references: 18501637
references: Neuropsychologia. 2011 Jul;49(9):2527-32
references: 21600905
references: Cereb Cortex. 2012 Nov;22(11):2672-9
references: 22156472
references: J Mol Neurosci. 2008;34(1):51-61
references: 18157658
references: Hum Brain Mapp. 2009 Sep;30(9):2731-45
references: 19072897
references: Psychopharmacology (Berl). 2003 Sep;169(3-4):314-20
references: 12610717
references: Acad Radiol. 2011 Jan;18(1):70-3
references: 21145029
references: Neuroimage. 2012 Jan 16;59(2):1023-7
references: 21930215
references: Med Educ. 2009 Apr;43(4):384-7
references: 19335581
references: Proc Natl Acad Sci U S A. 2001 Nov 6;98 (23 ):13272-7
references: 11687621
references: Neuroimage. 2012 Mar;60(1):471-5
references: 22197742
references: PLoS Biol. 2004 Apr;2(4):E97
references: 15094802
references: Neuroimage. 2010 Oct 1;52(4):1549-58
references: 20470894
references: Neuroscience. 2010 Dec 1;171(2):496-505
references: 20850507
references: Radiology. 2001 Apr;219(1):101-7
references: 11274543
references: J Neurosci. 2009 Apr 22;29(16):5319-25
references: 19386928
references: J Neurosci. 2010 Mar 3;30(9):3297-303
references: 20203189
references: PLoS One. 2008;3(10):e3556
references: 18958169
references: J Pers Assess. 2005 Aug;85(1):40-9
references: 16083383
references: Neuropsychologia. 2011 Oct;49(12):3466-73
references: 21906608
references: J Genet Psychol. 1986 Jun;147(2):183-8
references: 3746261
references: Percept Mot Skills. 1993 Jun;76(3 Pt 1):837-8
references: 8321595
references: Brain. 2010 Nov;133(11):3423-33
references: 20736190
references: Brain. 2009 Sep;132(Pt 9):2385-95
references: 19416950
references: Behav Brain Sci. 1999 Jun;22(3):491-517; discussion 518-69
references: 11301519
references: Neuroimage. 2007 Jan 1;34(1):137-43
references: 17070709
references: Neurosci Biobehav Rev. 2011 Apr;35(5):1219-36
references: 21185861
references: Front Hum Neurosci. 2013 Dec 18;7:875
references: 24385960
references: Mov Disord. 2004 Dec;19(12 ):1438-45
references: 15390073
references: Cortex. 2014 Feb;51:92-102
references: 24188648
references: Neuroimage. 2003 Jul;19(3):1233-9
references: 12880848
references: Hum Brain Mapp. 2013 Aug;34(8):1842-56
references: 22438164
references: Neuroimage. 2004 Jan;21(1):450-5
references: 14741682
references: Am J Med Genet. 2002 Aug 8;114(6):643-8
references: 12210280
references: Neurobiol Aging. 2008 Oct;29(10):1547-55
references: 17451845
references: Biol Psychiatry. 2005 Dec 1;58(11):908-12
references: 15992780
references: Psychiatry Res. 2000 Apr 24;94(1):67-76
references: 10788679
references: Psychiatr Dev. 1986 Autumn;4(3):167-226
references: 3809156
references: Brain Res Bull. 2009 Feb 16;78(2-3):69-74
references: 18950692
references: PLoS One. 2011;6(9):e25532
references: 21980485
references: PLoS One. 2011;6(8):e23175
references: 21886781
references: J Neurosci. 2011 Aug 24;31(34):12139-48
references: 21865456
references: J Magn Reson Imaging. 2001 Apr;13(4):534-46
references: 11276097
references: Psychol Rev. 1999 Jul;106(3):529-50
references: 10467897
references: J Pers Soc Psychol. 2003 Sep;85(3):499-506
references: 14498785
references: Brain Struct Funct. 2014 Jan;219(1):71-83
references: 23212300
references: J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):972-5
references: 15201352
references: PLoS One. 2010 Mar 22;5(3):e9818
references: 20339554
references: PLoS One. 2013 Nov 05;8(11):e79272
references: 24223921
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: Hum Brain Mapp. 2013 May;34(5):1025-34
references: 22139821
references: Am J Psychiatry. 2003 May;160(5):904-10
references: 12727694
references: Ann N Y Acad Sci. 1990;600:9-34; discussion 34-5
references: 2252340
references: Nat Rev Neurosci. 2008 Jan;9(1):58-65
references: 18094706
references: Psychopharmacology (Berl). 1993;112(1 Suppl):S1-4
references: 7831437
references: Arch Gen Psychiatry. 1993 Dec;50(12):975-90
references: 8250684
references: Neuroimage. 2011 Mar 15;55(2):681-7
references: 21111830
references: J Pharmacol Exp Ther. 1990 May;253(2):803-11
references: 1971022
references: Neurocase. 2003 Oct;9(5):369-79
references: 14972752
references: Biol Psychol. 2011 Apr;87(1):164-7
references: 21354260
references: Neuroscience. 1996 Nov;75(2):535-42
references: 8931016
references: Front Hum Neurosci. 2013 Aug 26;7:502
references: 23986684
references: Neuroimage. 2012 Feb 1;59(3):2899-907
references: 21988892
references: Mov Disord. 2004 Nov;19(11):1348-51
references: 15389994
references: J Neurophysiol. 2006 Feb;95(2):948-59
references: 16192338
references: Brain Res. 1979 Aug 17;172(1):169-73
references: 466461
references: Rev Neurosci. 2012 May 23;23(3):289-301
references: 22752786
references: Front Neurosci. 2007 Oct 15;1(1):225-36
references: 18982131
references: Psychol Rep. 2000 Jun;86(3 Pt 1):1050-8
references: 10876363
references: J Neurol. 2009 May;256(5):816-9
references: 19240966
references: Nat Rev Neurosci. 2011 Apr;12 (4):231-42
references: 21407245
references: Cereb Cortex. 2012 Dec;22(12):2921-9
references: 22235031
references: J Neurosci. 2007 Feb 28;27(9):2349-56
references: 17329432
references: Neuroimage. 2012 May 15;61(1):195-205
references: 22433658
references: Brain Struct Funct. 2014 Jul;219(4):1263-9
references: 23636224
references: Neuroimage. 2001 May;13(5):891-5
references: 11304084
references: Brain Cogn. 2002 Dec;50(3):396-413
references: 12480486
references: Br J Psychiatry. 2007 Aug;191:113-9
references: 17666494
references: Front Syst Neurosci. 2014 Oct 16;8:200
references: 25360090
references: Neuroimage. 2010 Jun;51(2):578-85
references: 20226253
references: Brain Res. 1982 Feb 18;234(1):53-63
references: 6120746
references: J Comp Neurol. 2005 Dec 5;493(1):147-53
references: 16254989
references: Methods. 2007 May;42(1):22-7
references: 17434412
references: Eur J Radiol. 2010 Aug;75(2):134-8
references: 19443158
references: Brain Struct Funct. 2014 May;219(3):793-803
references: 23494736
references: Shinrigaku Kenkyu. 1998 Feb;68(6):478-83
references: 9626737
references: Psychiatry Clin Neurosci. 2006 Dec;60(6):764-7
references: 17109713
references: Prog Brain Res. 2008;172:ix
references: 18772024
references: Neuron. 2012 Mar 22;73(6):1195-203
references: 22445346
references: Front Hum Neurosci. 2012 Nov 26;6:319
references: 23189050
references: Hum Brain Mapp. 2011 Nov;32(11):1973-85
references: 21259384
references: Hum Brain Mapp. 2010 Mar;31(3):398-409
references: 19722171
references: Hum Brain Mapp. 2011 Sep;32(9):1497-510
references: 20740644
references: AJNR Am J Neuroradiol. 2001 Jan;22(1):136-42
references: 11158899
references: Neuroimage. 2012 May 1;60(4):2035-41
references: 22369996
references: Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4608-13
references: 24619090
references: J Neurol Sci. 2009 Jan 15;276(1-2):179-83
references: 18952243
references: Curr Psychiatry Rep. 2000 Feb;2(1):62-6
references: 11122934
references: Neuroimage. 2010 May 15;51(1):11-8
references: 20171286
references: Brain Res. 1996 Dec 16;743(1-2):278-83
references: 9017256
references: Nat Neurosci. 2008 Jan;11(1):103-7
references: 18066057
references: Neurology. 1988 Mar;38(3):388-90
references: 3347342
references: Cognition. 2010 Jun;115(3):458-65
references: 20334856
references: Neuroimage. 2013 Aug 15;77:222-36
references: 23578577
references: Curr Opin Neurobiol. 1994 Apr;4(2):266-73
references: 8038587