title: Novel encoding methods for DNA-templated chemical libraries.
abstract: Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.
authors: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors: Gang
authors: G
authors: Li
authors: Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
authors: Wenlu
authors: W
authors: Zheng
authors: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors: Ying
authors: Y
authors: Liu
authors: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address: xiaoyuli@pku.edu.cn.
authors: Xiaoyu
authors: X
authors: Li
mesh_terms: D001665:Binding Sites; D055808:Drug Discovery; D015870:Gene Expression; D015723:Gene Library; D015335:Molecular Probes / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D019151:Peptide Library; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D019151:Peptide Library; D020135:Peptide Nucleic Acids; D054852:Small Molecule Libraries