title: Is high-dose rate RapidArc-based radiosurgery dosimetrically advantageous for the treatment of intracranial tumors?
abstract: In linac-based stereotactic radiosurgery (SRS) and radiotherapy (SRT), circular cone(s) or conformal arc(s) are conventionally used to treat intracranial lesions. However, when the target is in close proximity to critical structures, it is frequently quite challenging to generate a quality plan using these techniques. In this study, we investigated the dosimetric characteristics of using high-dose rate RapidArc (RA) technique for radiosurgical treatment of intracranial lesions. A total of 10 intracranial SRS/SRT cases previously planned using dynamic conformal arc (DCA) or cone-based techniques have been included in this study. For each case, 3 treatment plans were generated: (1) a DCA plan with multiple noncoplanar arcs, (2) a high-dose rate RA plan with arcs oriented the same as DCA (multiple-arc RA), and 3) a high-dose rate RA plan with a single coplanar arc (single-arc RA). All treatment plans were generated under the same prescription and similar critical structure dose limits. Plan quality for different plans was evaluated by comparing various dosimetric parameters such as target coverage, conformity index (CI), homogeneity index (HI), critical structures, and normal brain tissue doses as well as beam delivery time. With similar critical structure sparing, high-dose rate RA plans can achieve much better target coverage, dose conformity, and dose homogeneity than the DCA plans can. Plan quality indices CI and HI, for the DCA, multiple-arc RA, and single-arc RA techniques, were measured as 1.67 ± 0.39, 1.32 ± 0.28, and 1.38 ± 0.30 and 1.24 ± 0.11, 1.10 ± 0.04, and 1.12 ± 0.07, respectively. Normal brain tissue dose (V12Gy) was found to be similar for DCA and multiple-arc RA plans but much larger for the single-arc RA plans. Beam delivery was similar for DCA and multiple-arc RA plans but shorter with single-arc RA plans. Multiple-arc RA SRS/SRT can provide better treatment plans than conventional DCA plans, especially for complex cases.
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors: Bo
authors: B
authors: Zhao
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA. Electronic address: yangy2@upmc.edu.
authors: Yong
authors: Y
authors: Yang
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors: Xiang
authors: X
authors: Li
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors: Tianfang
authors: T
authors: Li
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors: Dwight E
authors: DE
authors: Heron
authors: Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.
authors: M
authors: M
authors: Saiful Huq
mesh_terms: D001930:Brain Injuries / Q000209:etiology / Q000517:prevention & control*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery*; D016371:Cranial Irradiation / Q000009:adverse effects / Q000379:methods; D019583:Dose Fractionation, Radiation; D006801:Humans; D059351:Organ Sparing Treatments / Q000379:methods; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011874:Radiometry; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
keywords: Dynamic conformal arc; High–dose rate Rapid Arc; Intracranial tumors; Stereotactic radiosurgery; VMAT