title: Evaluation of Ingenol mebutate efficacy for the treatment of actinic keratosis with Antera 3D camera.
abstract: OBJECTIVE
  Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs). Its incidence is growing at an emerging rate, becoming a worldwide problem especially for occupational ultraviolet (UV) rays exposure. Detectable lesions are often associated with ﬁeld changes, where the surrounding skin is altered and subclinical lesions may be present. Thus, a ﬁeld-directed therapy, such as topical treatment, should be preferred for the prevention of invasive cancer development. A retrospective analysis was made, evaluating the efficacy of ingenol-mebutate gel, using a novel device the 3D in vivo optical skin Imaging (Antera 3D, Miravex, Ireland).
  
  
  METHODS
  We included all patients with multiple non-hypertrophic Aks, to whom it was prescribed ingenol-mebutate gel, applied at the dosages of 0.015 for lesions in the scalp/face (for 3 consecutive days) and at the dosage of 0.05% for lesions in the trunk and/or extremities (for 2 consecutive days).
  
  
  RESULTS
  A reduction of the lesions and of median hemoglobin levels, after a follow-up of 60 days, was observed in 100% of patients.
  
  
  CONCLUSIONS
  Ingenol mebutate gel, the last topical molecule appeared in the Italian market showed its efficacy using Antera 3D also in terms of hemoglobin reduction. Therefore, this camera could be considered an useful tool for the identification of the area to be treated and for therapeutic follow-up.
authors: Department of Oncoematology-Dermatology, Azienda Policlinico Umberto I, "Sapienza" University, Rome, Italy. carmencantisanister@gmail.com.
authors: C
authors: C
authors: Cantisani
authors: G
authors: G
authors: Paolino
authors: P
authors: P
authors: Corsetti
authors: U
authors: U
authors: Bottoni
authors: D
authors: D
authors: Didona
authors: S
authors: S
authors: Calvieri
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004224:Diterpenes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D055623:Keratosis, Actinic / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: C486592:3-ingenyl angelate; D004224:Diterpenes