title: Extracellular volume fraction in dilated cardiomyopathy patients without obvious late gadolinium enhancement: comparison with healthy control subjects.
abstract: To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 - hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 - pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University Medical Center, Seoul, South Korea.
authors: Yoo Jin
authors: YJ
authors: Hong
authors: Chul Hwan
authors: CH
authors: Park
authors: Young Jin
authors: YJ
authors: Kim
authors: Jin
authors: J
authors: Hur
authors: Hye-Jeong
authors: HJ
authors: Lee
authors: Sae Rom
authors: SR
authors: Hong
authors: Young Joo
authors: YJ
authors: Suh
authors: Andreas
authors: A
authors: Greiser
authors: Mun Young
authors: MY
authors: Paek
authors: Byoung Wook
authors: BW
authors: Choi
authors: Tae Hoon
authors: TH
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D005355:Fibrosis; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013318:Stroke Volume; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
references: Circulation. 2006 Apr 11;113(14):1807-16
references: 16567565
references: Magn Reson Imaging. 1994;12(4):589-98
references: 8057763
references: Mayo Clin Proc. 2011 Nov;86(11):1095-102
references: 22033254
references: Cardiology. 1996;87 Suppl 1:2-10
references: 8681317
references: J Magn Reson Imaging. 2004 Oct;20(4):588-93
references: 15390232
references: JAMA. 2013 Mar 6;309(9):896-908
references: 23462786
references: J Cardiovasc Magn Reson. 2012 Sep 11;14:64
references: 22967246
references: Circ Cardiovasc Imaging. 2013 May 1;6(3):373-83
references: 23553570
references: J Cardiovasc Magn Reson. 2004;6(4):817-27
references: 15646885
references: J Am Coll Cardiol. 2008 Nov 4;52(19):1574-80
references: 19007595
references: Circulation. 2002 Jan 29;105(4):539-42
references: 11815441
references: Eur Heart J. 2012 May;33(10):1268-78
references: 22279111
references: Heart. 2012 Oct;98 (19):1436-41
references: 22936681
references: Circulation. 2003 Jul 8;108(1):54-9
references: 12821550
references: JACC Cardiovasc Imaging. 2012 Sep;5(9):897-907
references: 22974802
references: Radiology. 2012 Feb;262(2):403-22
references: 22282181
references: J Cardiovasc Magn Reson. 2011 Nov 28;13:75
references: 22123333
references: Magn Reson Imaging Clin N Am. 2008 May;16(2):165-83, vii
references: 18474325
references: JACC Cardiovasc Imaging. 2012 Apr;5(4):370-7
references: 22498326
references: Circulation. 2010 Jul 13;122(2):138-44
references: 20585010
references: Ann Med. 1998 Aug;30 Suppl 1:3-8
references: 9800877
references: J Am Coll Cardiol. 2011 Feb 22;57(8):891-903
references: 21329834
references: J Am Coll Cardiol. 1992 Jan;19(1):43-7
references: 1729344
references: J Am Coll Cardiol. 2008 Jun 24;51(25):2414-21
references: 18565399
references: J Cardiovasc Magn Reson. 2013 Oct 14;15:92
references: 24124732
references: J Am Coll Cardiol. 2006 Nov 21;48(10):1977-85
references: 17112987
references: J Cardiovasc Magn Reson. 2013 Jan 20;15:13
references: 23331520