title: Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh-Lamb equation.
abstract: We demonstrate the use of a modified Rayleigh–Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young’s moduli of the samples using the Rayleigh–Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n ¼ 3) and then applied to porcine corneas (n ¼ 3) in situ. The Young’s moduli of the porcine corneas were estimated to be ∼60 kPa with a shear viscosity ∼0.33 Pa · s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States.
authors: Zhaolong
authors: Z
authors: Han
authors: University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, United States.
authors: Salavat R
authors: SR
authors: Aglyamov
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States.
authors: Jiasong
authors: J
authors: Li
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States.
authors: Manmohan
authors: M
authors: Singh
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United StatescBaylor College of Medicine, Department of Molecular Physiology and Biophysics, Houston, Texas 77030, United States.
authors: Shang
authors: S
authors: Wang
authors: University of Houston, College of Optometry, Houston, Texas 77204, United States.
authors: Srilatha
authors: S
authors: Vantipalli
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States.
authors: Chen
authors: C
authors: Wu
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States.
authors: Chih-Hao
authors: CH
authors: Liu
authors: University of Alabama, School of Optometry, Birmingham, Alabama 35294, United States.
authors: Michael D
authors: MD
authors: Twa
authors: University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United StatescBaylor College of Medicine, Department of Molecular Physiology and Biophysics, Houston, Texas 77030, United States.
authors: Kirill V
authors: KV
authors: Larin
mesh_terms: D000465:Algorithms; D000818:Animals; D003315:Cornea / Q000000981:diagnostic imaging*; D055119:Elastic Modulus / Q000502:physiology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000379:methods*; D014783:Viscosity
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