title: Assessment of vascular response after drug-eluting stents implantation in patients with diabetes mellitus: an optical coherence tomography sub-study of the J-DESsERT.
abstract: Even in the drug-eluting stent era, diabetes mellitus (DM) patients have high incidences of restenosis and repeat revascularization after percutaneous coronary intervention. The aim of this study was to compare vascular response after stent implantation between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) by using optical coherence tomography (OCT) in DM patients as well as in non-DM patients. In the Japan-Drug Eluting Stents Evaluation; a Randomized Trial (J-DESsERT), the OCT sub-study enrolled 75 patients who underwent 8 months follow-up imaging after SES or PES implantation. Mean neointimal hyperplasia (NIH) thickness was significantly thinner in SES than PES in the DM group (77 ± 47 vs. 201 ± 114 μm, p < 0.001) and in the non-DM group (84 ± 37 vs. 212 ± 128 μm, p < 0.001). Unevenness of NIH thickness in longitudinal axis was significantly smaller in SES than PES in the DM group (348 ± 191 vs. 726 ± 385 μm, p < 0.001) and in the non-DM group (344 ± 174 vs. 679 ± 314 μm, p < 0.001). The percentage of uncovered struts was significantly greater in SES than PES in the DM group (24 ± 4 vs. 9 ± 14 %, p < 0.001) and in the non-DM group (16 ± 16 vs. 3 ± 4 %, p = 0.002). Compared with PES, SES showed more potent NIH inhibition in DM patients as well as in non-DM patients.
authors: Department of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan. takakubo@wakayama-med.ac.jp.
authors: Takashi
authors: T
authors: Kubo
authors: Department of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.
authors: Takashi
authors: T
authors: Akasaka
authors: Department of Cardiovascular Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.
authors: Takashi
authors: T
authors: Tanimoto
authors: Cardiovascular Center, Nippon Medical School, Chiba-Hokusoh Hospital, Chiba, Japan.
authors: Masamichi
authors: M
authors: Takano
authors: Department of Cardiology, Hoshi General Hospital, Koriyama, Japan.
authors: Yoshitane
authors: Y
authors: Seino
authors: Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan.
authors: Kenya
authors: K
authors: Nasu
authors: Division of Cardiology, Department of Internal Medicine, Memorial Heart Center, Iwate Medical School, Morioka, Japan.
authors: Tomonori
authors: T
authors: Itoh
authors: Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
authors: Kyoichi
authors: K
authors: Mizuno
authors: Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan.
authors: Hiroyuki
authors: H
authors: Okura
authors: Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors: Toshiro
authors: T
authors: Shinke
authors: Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Jun-Ichi
authors: J
authors: Kotani
authors: Division of Cardiology, Nagoya City East Medical Center, Nagoya, Japan.
authors: Shigenori
authors: S
authors: Ito
authors: Cardiovascular Medicine Center, Fukuoka Sanno Hospital, Fukuoka, Japan.
authors: Hiroyoshi
authors: H
authors: Yokoi
authors: Division of Cardiology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan.
authors: Toshiya
authors: T
authors: Muramatsu
authors: Division of Cardiovascular Medicine, Ohashi Medical Center, Toho University, Tokyo, Japan.
authors: Masato
authors: M
authors: Nakamura
authors: Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Shinsuke
authors: S
authors: Nanto
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003920:Diabetes Mellitus; D054855:Drug-Eluting Stents; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D058426:Neointima / Q000473:pathology; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011446:Prospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014654:Vascular Patency / Q000502:physiology*
keywords: Drug-eluting stents; Neointima; Optical coherence tomography; Percutaneous coronary intervention
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