title: Total synthesis of Ivorenolide A following a base-induced elimination protocol.
abstract: A concise and stereocontrolled first total synthesis of Ivorenolide A (1) is reported in 16 longest linear steps with a 13.4% overall yield starting from (+)-diethyl tartrate (DET). Key features are base-induced elimination protocol for the construction of chiral propargyl alcohols in both fragments, Pd-catalyzed cross-coupling of terminal acetylenes, and Shiina's 2-methyl-6-nitrobezoic anhydride (MNBA) mediated macrolactonization.
authors: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad-500007, India.
authors: Debendra K
authors: DK
authors: Mohapatra
authors: Gonela
authors: G
authors: Umamaheshwar
authors: R Nageshwar
authors: RN
authors: Rao
authors: T Srinivasa
authors: TS
authors: Rao
authors: Sudheer Kumar
authors: SK
authors: R
authors: Jhillu S
authors: JS
authors: Yadav
mesh_terms: D000468:Alkalies / Q000737:chemistry; D002384:Catalysis; D007783:Lactones / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000468:Alkalies; D007783:Lactones; D018942:Macrolides; C581291:ivorenolide A