title: Ischemia-modified albumin and inflammatory biomarkers in patients with prostate cancer.
abstract: BACKGROUND
  Prostate cancer has become a public health problem in many countries and there is evidence which indicates that inflammation and oxidative stress play a key role in the pathogenesis of this disease. Thus, the aim of this study was to evaluate the concentrations of new biomarkers of oxidative stress, ischemia-modified albumin (IMA) and ferric reducing ability of plasma (FRAP), as well as the inflammatory markers in patients with prostate cancer.
  
  
  METHODS
  CRP, IMA, FRAP, fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, creatinine, albumin, AST, ALT, ADA, total PSA (tPSA), free PSA, and proportion of free PSA (fPSA%) were measured in 25 patients with prostate cancer and in 30 healthy subjects.
  
  
  RESULTS
  tPSA, CRP, and IMA were significantly higher in patients with prostate cancer. In contrast, fPSA% and FRAP were significantly lower in these patients. However, no significant differences were observed when IMA values were adjusted for serum albumin. Significant correlations were also observed for tPSA and CRP (r = 0.5104, p < 0.001) and for fPSA% and CRP (r = -0.5059, p < 0.001).
  
  
  CONCLUSIONS
  We demonstrated that both inflammatory and oxidative processes are increased during prostate cancer and also that there is a reduction of antioxidant defenses in this pathology.
authors: Rafael Arrua
authors: RA
authors: Da Silveira
authors: Carine Lima
authors: CL
authors: Hermes
authors: Taís Corrêa
authors: TC
authors: Almeida
authors: Guilherme Vargas
authors: GV
authors: Bochi
authors: Karine Santos
authors: KS
authors: De Bona
authors: Maria Beatriz
authors: MB
authors: Moretto
authors: Rafael Noal
authors: RN
authors: Moresco
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011471:Prostatic Neoplasms / Q000097:blood* / Q000276:immunology; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014408:Biomarkers, Tumor; D018836:Inflammation Mediators; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human