title: The relation of matrix metalloproteinase 1, 2, 3 expressions with clinical and radiological findings in primary and recurrent lumbar disc herniations.
abstract: OBJECTIVE
  In this study, our aim was to examine if matrix metalloproteinase expressions (MMP-1, MMP-2, MMP-3) in patients operated with a lumbar disc hernia diagnosis are different in terms of clinical and neuroradiological findings.
  
  
  METHODS
  The study included 80 patients treated with micro discectomy for lumbar disc hernia. Degeneration was scored via magnetic resonance (MR) images. MMP-1, MMP-2, and MMP-3 antibodies were used for immunohistochemical evaluation of degenerated disc materials. MMP expressions were compared between primary and recurrent cases, and correlation analysis was conducted.
  
  
  RESULTS
  Discectomy material showed higher expression of MMP-1 and MMP-3 in cases of recurrent lumbar disc herniation than in primary herniation. There was no significant relationship between MMP expression and MR degeneration score.
  
  
  CONCLUSIONS
  MMP-1 and MMP-3 expressions were significantly higher in recurrent cases in terms of magnetic resonance degeneration score. We assume that the higher co-expression of MMP-1 and MMP-3 might be used in targeted treatment regiemens in patients with recurrent LDH.
authors: Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Pathology, Istanbul, Turkey.
authors: Seyma
authors: S
authors: Ozkanli
authors: Tuncay
authors: T
authors: Kaner
authors: Mustafa
authors: M
authors: Efendioglu
authors: Recep
authors: R
authors: Basaran
authors: Mehmet
authors: M
authors: Senol
authors: Ebru
authors: E
authors: Zemheri
authors: Ahmet Ferruh
authors: AF
authors: Gezen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017364:Collagenases / Q000378:metabolism*; D017586:Diskectomy; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008159:Lumbar Vertebrae / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D017364:Collagenases; D019278:Matrix Metalloproteinase 3; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1