title: Leprosy nephropathy: a review of clinical and histopathological features.
abstract: Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.
authors: School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil.
authors: Geraldo Bezerra da
authors: GB
authors: Silva Junior
authors: Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Elizabeth De Francesco
authors: Ede F
authors: Daher
authors: Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Roberto da Justa
authors: Rda J
authors: Pires Neto
authors: Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Eanes Delgado Barros
authors: ED
authors: Pereira
authors: School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
authors: Gdayllon Cavalcante
authors: GC
authors: Meneses
authors: School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil.
authors: Sônia Maria Holanda Almeida
authors: SM
authors: Araújo
authors: Department of Internal Medicine, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors: Elvino José Guardão
authors: EJ
authors: Barros
mesh_terms: D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology* / Q000473:pathology; D007918:Leprosy / Q000150:complications* / Q000473:pathology; D009166:Mycobacterium leprae
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