title: Roles of the Hippo pathway in lung development and tumorigenesis.
abstract: Lung cancer is the most commonly diagnosed cancer and accounts for one fifth of all cancer deaths worldwide. Although significant progress has been made toward our understanding of the causes of lung cancer, the 5-year survival is still lower than 15%. Therefore, there is an urgent need for novel lung cancer biomarkers and drug targets. The Hippo signaling pathway is an emerging signaling pathway that regulates various biological processes. Recently, increasing evidence suggests that the Hippo pathway may play important roles in not only lung development but also lung tumorigenesis. In this review article, we will summarize the most recent advances and predict future directions on this new cancer research field.
authors: Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
authors: Benjamin
authors: B
authors: Yeung
authors: Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
authors: Jihang
authors: J
authors: Yu
authors: Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
authors: Xiaolong
authors: X
authors: Yang
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D063646:Carcinogenesis; D000090683:Hippo Signaling Pathway; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D035683:MicroRNAs / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000502:physiology; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D035683:MicroRNAs; D010750:Phosphoproteins; C411762:RASSF1 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; C092745:LATS1 protein, human; C406449:LATS2 protein, human; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases
keywords: Hippo pathway; TAZ; YAP; development; lung cancer; tumorigenesis