title: Single nucleotide polymorphisms in non-coding region of the glucocorticoid receptor gene and prednisone response in childhood acute lymphoblastic leukemia.
abstract: Poor prednisone response predicts an inferior outcome in pediatric acute lymphoblastic leukemia (ALL) in Berlin-Frankfurt-Münster (BFM) treatment protocols. Here, we investigated five single nucleotide polymorphisms (SNPs) in both the coding and non-coding regions of the glucocorticoid receptor (GR) gene, and analyzed their association with prednisone responsiveness in vivo in 63 pediatric patients with ALL in China. Of the five SNPs, the rs41423247 and rs7701443 polymorphisms were significantly associated with prednisone response at the allelic level (rs41423247 odds ratio [OR] = 9.58; 95% confidence interval [CI]: 1.23-74.21; p = 0.01; rs7701443 OR = 3.12; 95% CI: 1.08-9; p = 0.02). Two polymorphisms (rs6189/6190 and rs6198) were not observed in the study cohort. Haplotypes composed of CCC alleles and TCG alleles at three loci (rs7701443, Tth111I and BclI) were both associated with prednisone response (p = 0.013; p = 0.028). Our results suggested that polymorphisms in the non-coding region of the GR gene were associated with prednisone response in vivo in pediatric ALL in Han Chinese.
authors: Department of Childhood Hematology and Oncology.
authors: Lu
authors: L
authors: Xue
authors: Chunhuai
authors: C
authors: Li
authors: Yue
authors: Y
authors: Wang
authors: Wei
authors: W
authors: Sun
authors: Cui
authors: C
authors: Ma
authors: Yongyan
authors: Y
authors: He
authors: Yongli
authors: Y
authors: Yu
authors: Lu
authors: L
authors: Cai
authors: Liying
authors: L
authors: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019940:Genes, bcl-1 / Q000235:genetics; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use*; D011965:Receptors, Glucocorticoid / Q000235:genetics*
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D011241:Prednisone
keywords: Acute lymphoblastic leukemia; childhood; glucocorticoid receptor; polymorphism; prednisone response