title: Altered splenic miRNA expression profile in H1N1 swine influenza.
abstract: Previous studies have demonstrated the key regulatory roles played by microRNAs (miRNAs) in influenza virus-host interactions. To gain more insight into the contribution of miRNAs to the host immune response, spleen tissues from mice infected with A/Swine/GD/2/12 (H1N1) virus were harvested 5 days postinfection, and miRNA deep sequencing was performed. The results showed that 50 miRNAs were modulated. Interestingly, pathway analysis of miRNAs and targets showed that upregulated miR-124-3p interacts with innate immune-related pathways such as the Toll-like receptor pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway and JAK-STAT signaling pathway, and this might play a major role in the anti-inflammatory response. Further understanding of the roles played by these miRNAs in influenza virus infection will provide new insights into host-pathogen interactions.
authors: College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
authors: Liangzong
authors: L
authors: Huang
authors: Jun
authors: J
authors: Ma
authors: Yankuo
authors: Y
authors: Sun
authors: Yanli
authors: Y
authors: Lv
authors: Wen
authors: W
authors: Lin
authors: Mingjie
authors: M
authors: Liu
authors: Changsong
authors: C
authors: Tu
authors: Pei
authors: P
authors: Zhou
authors: Wanjun
authors: W
authors: Gu
authors: Shuo
authors: S
authors: Su
authors: Guihong
authors: G
authors: Zhang
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D012367:RNA, Viral / Q000235:genetics* / Q000276:immunology; D013154:Spleen / Q000276:immunology / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000235:genetics / Q000276:immunology / Q000821:virology*
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral