title: Prometastatic NOTCH Signaling in Colon Cancer.
abstract: Dysregulation of NOTCH signaling contributes to the development of colorectal cancer, but how this pathway regulates metastasis has so far remained unclear. Sonoshita and colleagues identified a novel NOTCH-driven metastasis pathway that is amenable to therapeutic intervention and generated a companion diagnostic tool that allows analysis of pathway activity in human tumor tissue sections.
authors: University Medical Center Utrecht, Utrecht, the Netherlands. o.kranenburg@umcutrecht.nl.
authors: Onno
authors: O
authors: Kranenburg
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D064067:Rho Guanine Nucleotide Exchange Factors / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch; D064067:Rho Guanine Nucleotide Exchange Factors; D017346:Protein Serine-Threonine Kinases