title: Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.
abstract: Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.
authors: Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
authors: Sheila L
authors: SL
authors: MacRae
authors: Quanwei
authors: Q
authors: Zhang
authors: Christophe
authors: C
authors: Lemetre
authors: Inge
authors: I
authors: Seim
authors: Robert B
authors: RB
authors: Calder
authors: Jan
authors: J
authors: Hoeijmakers
authors: Yousin
authors: Y
authors: Suh
authors: Vadim N
authors: VN
authors: Gladyshev
authors: Andrei
authors: A
authors: Seluanov
authors: Vera
authors: V
authors: Gorbunova
authors: Jan
authors: J
authors: Vijg
authors: Zhengdong D
authors: ZD
authors: Zhang
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D016678:Genome / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics*; D051379:Mice; D019577:Mole Rats; D009154:Mutation; D051381:Rats
keywords: aging; gene duplication; genome maintenance; longevity; mutation rate
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