title: Difluorohomologation of ketones.
abstract: A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.
authors: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors: Mikhail D
authors: MD
authors: Kosobokov
authors: Vitalij V
authors: VV
authors: Levin
authors: Marina I
authors: MI
authors: Struchkova
authors: Alexander D
authors: AD
authors: Dilman
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003521:Cyclopropanes / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D012821:Silanes