title: [Hashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension].
abstract: BACKGROUND
  Recent studies show an association between autoimmune thyroiditis and systemic sclerosis (SSc) and suggest that this condition may interfere with the ES phenotype. However these studies evaluate the autoimmune thyroiditis as a whole and none of them specifically addresses Hashimoto's thyroiditis (HT) in SSc.
  
  
  OBJECTIVE
  To investigate the presence of HT in SSc patients and its possible association with disease manifestations.
  
  
  METHODS
  Clinical manifestations of hypothyroidism, TSH and anti-thyroid auto antibodies (anti-TPO. anti TBG and TRAb) were studied in 56 patients with SSc. SSc patients with HT were compared with SSc patients without thyroiditis.
  
  
  RESULTS
  HT was observed in 19.64% of patients with SSc. No association was observed between HT and the different forms of disease or profile of autoantibodies. Likewise, there was no difference between the mean modified Rodnan score and presence of Raynaud's phenomenon, scars, digital necrosis, myositis, arthritis, sicca symptoms, esophageal dysmotility and scleroderma renal crisis when the groups were compared. On the other hand, patients with HT had higher frequency of pulmonary hypertension in relation to patients without HT (66.6% vs 22.5%, p=0.016).
  
  
  CONCLUSIONS
  In the studied sample patients with ES and HT had higher prevalence of pulmonary hypertension. Long-term follow-up studies with a larger number of TH and SSc patients are needed to confirm these data.
authors: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors: Ciliana Cardoso B
authors: CC
authors: Costa
authors: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors: Morgana
authors: M
authors: Medeiros
authors: Faculdade Evangélica do Paraná, Curitiba, PR, Brasil.
authors: Karen
authors: K
authors: Watanabe
authors: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil.
authors: Patricia
authors: P
authors: Martin
authors: Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brasil. Electronic address: tskare@onda.com.br.
authors: Thelma L
authors: TL
authors: Skare
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications*; D055815:Young Adult
keywords: Esclerodermia; Esclerose sistêmica; Hashimoto thyroiditis; Hipertensão pulmonar; Pulmonary hypertension; Scleroderma; Systemic sclerosis; Tireoidite de Hashimoto