title: Serum fetuin-A levels in subjects with and without choroid plexus calcification.
abstract: Choroid plexus is an intraventricular plexus of tissue which is responsible for secretion of cerebrospinal fluid. Calcification of choroid plexus is found to be associated with age and gender. One of novel and popular glycoprotein that involves in inhibition of mineralization is human fetuin-A. In our study, we investigated plasma levels of fetuin-A in subjects with and without choroid plexus calcification. For this purpose, 41 subjects with choroid plexus calcification and 41 age and gender matched subjects with normal appearing choroid plexus were recruited. Calcified and normal choroid plexus tissue identified on computed tomography images. Overnight fasting venous blood samples were collected to measure serum fetuin-A levels using a human fetuin-A enzyme-linked immunosorbent assay kit. Statistically significant difference concerning the median concentration of fetuin-A was found between subjects with and without choroid plexus calcification (p: 0.040). Significance was also present between male subgroups (p: 0.017) and 18-27 years age subgroups (p: 0.025). Our results suggest that fetuin-A has an potent role in calcification process of choroid plexus.
authors: Section of Neurology, Regional Education and Research Hospital, Erzurum, Turkey.
authors: Mustafa
authors: M
authors: Ceylan
authors: Section of Neurology, Regional Education and Research Hospital, Erzurum, Turkey.
authors: Omer Faruk
authors: OF
authors: Bayraktutan
authors: Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.
authors: Omer
authors: O
authors: Atis
authors: Section of Radiology, Regional Education and Research Hospital, Erzurum, Turkey. Electronic address: dr_ayalcin@hotmail.com.
authors: Ahmet
authors: A
authors: Yalcin
authors: Department of Neurology, School of Medicine, Sakarya University, Sakarya, Turkey.
authors: Dilcan
authors: D
authors: Kotan
authors: Section of Neurology, Regional Education and Research Hospital, Erzurum, Turkey.
authors: Tulay
authors: T
authors: Yilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002831:Choroid Plexus / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012737:Sex Factors; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D060749:alpha-2-HS-Glycoprotein
keywords: Calcification; Choroid plexus; Fetuin-A