title: Echogenicity as a surrogate for bioresorbable everolimus-eluting scaffold degradation: analysis at 1-, 3-, 6-, 12- 18, 24-, 30-, 36- and 42-month follow-up in a porcine model.
abstract: The objective of the study is to validate intravascular quantitative echogenicity as a surrogate for molecular weight assessment of poly-l-lactide-acid (PLLA) bioresorbable scaffold (Absorb BVS, Abbott Vascular, Santa Clara, California). We analyzed at 9 time points (from 1- to 42-month follow-up) a population of 40 pigs that received 97 Absorb scaffolds. The treated regions were analyzed by echogenicity using adventitia as reference, and were categorized as more (hyperechogenic or upperechogenic) or less bright (hypoechogenic) than the reference. The volumes of echogenicity categories were correlated with the measurements of molecular weight (Mw) by gel permeation chromatography. Scaffold struts appeared as high echogenic structures. The quantification of grey level intensity in the scaffold-vessel compartment had strong correlation with the scaffold Mw: hyperechogenicity (correlation coefficient = 0.75; P < 0.01), upperechogenicity (correlation coefficient = 0.63; P < 0.01) and hyper + upperechogenicity (correlation coefficient = 0.78; P < 0.01). In the linear regression, the R(2) for high echogenicity and Mw was 0.57 for the combination of hyper and upper echogenicity. IVUS high intensity grey level quantification is correlated to Absorb BVS residual molecular weight and can be used as a surrogate for the monitoring of the degradation of semi-crystalline polymers scaffolds.
authors: Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, s-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors: Carlos M
authors: CM
authors: Campos
authors: Yuki
authors: Y
authors: Ishibashi
authors: Jeroen
authors: J
authors: Eggermont
authors: Shimpei
authors: S
authors: Nakatani
authors: Yun Kyeong
authors: YK
authors: Cho
authors: Jouke
authors: J
authors: Dijkstra
authors: Johan H C
authors: JH
authors: Reiber
authors: Alexander
authors: A
authors: Sheehy
authors: Jennifer
authors: J
authors: Lane
authors: Marika
authors: M
authors: Kamberi
authors: Richard
authors: R
authors: Rapoza
authors: Laura
authors: L
authors: Perkins
authors: Hector M
authors: HM
authors: Garcia-Garcia
authors: Yoshinobu
authors: Y
authors: Onuma
authors: Patrick W
authors: PW
authors: Serruys
mesh_terms: D020341:Absorbable Implants; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D003460:Crystallization; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D019344:Lactic Acid / Q000737:chemistry; D016014:Linear Models; D023421:Models, Animal; D015588:Observer Variation; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors; D018084:Ultrasonography, Interventional
chemical_list: D002317:Cardiovascular Agents; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D000068338:Everolimus
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