title: Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats.
abstract: Bupropion is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor used as smoking cessation and antidepressant drug with a lower incidence of male sexual dysfunction. We showed previously that sibutramine, a norepinephrine/serotonine reuptake inhibitor, reduced male rat fertility. As there are no studies evaluating the impact of bupropion treatment on spermatic parameters and male fertility, we evaluated the effects of bupropion treatment (15 and 30 mg kg(-1), 30 days) on sexual behavior, spermatic parameters and fertility of male Wistar rats and on the epididymal duct in vitro contractility. Bupropion 15 mg kg(-1) increased the serum luteinizing hormone level and the epididymal duct contractility, but the sperm quality was not affected. At 30 mg kg(-1) bupropion impaired sperm quality increasing the incidence of non-progressive sperm. The male sexual behavior and fertility were not modified at both bupropion doses. These results, in rats, suggest the importance of studies evaluating the effects of bupropion on the human male sperm quality.
authors: Department of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Marilia Martins
authors: MM
authors: Cavariani
authors: Department of Pharmacology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Luiz Ricardo
authors: LR
authors: de Almeida Kiguti
authors: Department of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Josiane
authors: J
authors: de Lima Rosa
authors: Department of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Gabriel Adan
authors: GA
authors: de Araújo Leite
authors: Department of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Patrícia Villela E
authors: PV
authors: Silva
authors: Department of Pharmacology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: André Sampaio
authors: AS
authors: Pupo
authors: Department of Morphology, Institute of Biosciences, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil.
authors: Wilma
authors: W
authors: De Grava Kempinas
mesh_terms: D000818:Animals; D016642:Bupropion / Q000633:toxicity*; D018765:Dopamine Uptake Inhibitors / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D005298:Fertility / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013083:Sperm Transport / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D007986:Luteinizing Hormone
keywords: bupropion; epididymal contraction; norepinephrine transporter; sperm quality; sperm transit time