title: MAGI2/S-SCAM outside brain.
abstract: Membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI)2 (also called synaptic scaffolding molecule (S-SCAM), atrophin-1-interacting protein 1, activin receptor-interacting protein 1) is a scaffold protein that binds a wide variety of receptors, cell adhesion molecules and signalling molecules. It also interacts with other scaffold proteins and adaptors, and forms a protein network that supports cell junctions. As it is highly expressed in brain, the study on its roles in synaptic organization initially preceded. However, mounting evidence indicates that MAGI2/S-SCAM functions as a tumour suppressor and plays essential roles to maintain the integrity of cell structures in non-neuronal tissues. We review the articles regarding to MAGI2/S-SCAM outside brain and discuss future perspectives for the research of MAGI family proteins.
authors: Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
authors: Shunta
authors: S
authors: Nagashima
authors: Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
authors: Manami
authors: M
authors: Kodaka
authors: Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan.
authors: Hiroaki
authors: H
authors: Iwasa
authors: Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences and Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan yuhammch@tmd.ac.jp.
authors: Yutaka
authors: Y
authors: Hata
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001932:Brain Neoplasms / Q000503:physiopathology; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D051528:Guanylate Kinases; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D025521:Tumor Suppressor Proteins; D051528:Guanylate Kinases; C485777:MAGI2 protein, human
keywords: cancer; intestine; kidney; scaffold protein; synapse