title: Vitamin D insufficiency in obese children and relation with lipid profile.
abstract: Vitamin D (25OHD) deficiency is reported in obese children. Low 25OHD levels are associated with dyslipidemia and increased risk of cardiovascular complication in adulthood. Within an observational study, 120 obese subjects in pediatric age were enrolled: 59 had 25OHD <20 ng/ml (group A) while 61 had 25OHD >20 ng/ml (group B). Group A versus Group B showed elevated total cholesterol (TC), p = 0.017, low-density lipoprotein cholesterol (LDL-C), p = 0.045, and parathormone (PTH), p = 0.008. Apolipoprotein B (ApoB) showed a similar trend, p = 0.074. Negative correlations were found between 25OHD and the following parameters: TC (ρ = -0.22, p = 0.01), LDL (ρ = -0.22; p = 0.03), ApoB (ρ = -0.20; p = 0.03), and PTH (ρ = -0.33, p = 0.003). No differences in High Lipoprotein Cholesterol (HDL-C) were found. In multivariate regression the most powerful predictor for explaining 25OHD variation were TC (p = 0.048) and PTH (p = 0.055). Within a pediatric obese population an association between 25OHD low levels and unfavourable lipid patterns has been found.
authors: Pediatric Clinic, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico , Milan , Italy .
authors: Roberto Ercole
authors: RE
authors: Rusconi
authors: Valentina
authors: V
authors: De Cosmi
authors: Ghilardi
authors: G
authors: Gianluca
authors: Claudia
authors: C
authors: Giavoli
authors: Carlo
authors: C
authors: Agostoni
mesh_terms: D001055:Apolipoproteins B / Q000097:blood; D002648:Child; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology*; D006801:Humans; D008055:Lipids / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood*; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D010281:Parathyroid Hormone; D014807:Vitamin D; D002784:Cholesterol; C104450:25-hydroxyvitamin D
keywords: Cardiovascular risk; lipoproteins; obesity; vitamin D