title: Endolymphatic sac tumors.
abstract: Endolymphatic sac tumors (ELST) are slow-growing, locally aggressive, low-grade malignancies that originate from the epithelium of the endolymphatic duct and sac. ELST often present with sensorineural hearing loss, tinnitus, and vertigo, which may mimic Meniere disease. Large tumors may present with additional cranial neuropathies. Management is primarily via microsurgical excision. Radiation therapy has a limited role for residual or unresectable disease. Early detection may enable hearing preservation techniques. ELST have an association with von Hippel-Lindau disease.
authors: Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Cameron C
authors: CC
authors: Wick
authors: Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Nauman F
authors: NF
authors: Manzoor
authors: Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Otology, Neurotology, and Balance Disorders, Department of Otolaryngology - Head and Neck Surgery, Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors: Maroun T
authors: MT
authors: Semaan
authors: Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Otology, Neurotology, and Balance Disorders, Department of Otolaryngology - Head and Neck Surgery, Ear, Nose, and Throat Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: Cliff.Megerian@UHhospitals.org.
authors: Cliff A
authors: CA
authors: Megerian
mesh_terms: D004712:Endolymphatic Sac / Q000473:pathology / Q000601:surgery*; D006319:Hearing Loss, Sensorineural; D006801:Humans; D008279:Magnetic Resonance Imaging; D008575:Meniere Disease / Q000175:diagnosis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D014012:Tinnitus; D014057:Tomography, X-Ray Computed; D014717:Vertigo; D006623:von Hippel-Lindau Disease / Q000150:complications*
keywords: Endolymphatic sac tumors; Hearing preservation; Meniere syndrome; Von Hippel–Lindau