title: Cell death and morphogenesis during early mouse development: are they interconnected?
abstract: Shortly after implantation the embryonic lineage transforms from a coherent ball of cells into polarized cup shaped epithelium. Recently we elucidated a previously unknown apoptosis-independent morphogenic event that reorganizes the pluripotent lineage. Polarization cues from the surrounding basement membrane rearrange the epiblast into a polarized rosette-like structure, where subsequently a central lumen is established. Thus, we provided a new model revising the current concept of apoptosis-dependent epiblast morphogenesis. Cell death however has to be tightly regulated during embryogenesis to ensure developmental success. Here, we follow the stages of early mouse development and take a glimpse at the critical signaling and morphogenic events that determine cells destiny and reshape the embryonic lineage.
authors: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
authors: Ivan
authors: I
authors: Bedzhov
authors: Magdalena
authors: M
authors: Zernicka-Goetz
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001755:Blastocyst / Q000166:cytology; D010064:Embryo Implantation / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D005855:Germ Layers / Q000166:cytology* / Q000502:physiology; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D011247:Pregnancy
keywords: apoptosis; blastocyst; egg cylinder; epiblast; implantation; morphogenesis
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