title: Olopatadine, a non-sedating H1 antihistamine, decreases the nocturnal scratching without affecting sleep quality in atopic dermatitis.
abstract: We have demonstrated for the first time that a second-generation antihistamine ameliorates nocturnal scratching behavior in atopic dermatitis patients using a modified wristwatch-type acoustic scratching counting system that we have recently developed. We also analyzed the sleep quality by simultaneous recording of electroencephalogram, and found that sleep quality was unaffected.
authors: Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.
authors: Keiichi
authors: K
authors: Yamanaka
authors: Eishi
authors: E
authors: Motomura
authors: Yuichi
authors: Y
authors: Noro
authors: Koji
authors: K
authors: Umeda
authors: Takuya
authors: T
authors: Morikawa
authors: Kumi
authors: K
authors: Umeda-Togami
authors: Youichi
authors: Y
authors: Omoto
authors: Kenichi
authors: K
authors: Isoda
authors: Makoto
authors: M
authors: Kondo
authors: Kenshiro
authors: K
authors: Tsuda
authors: Masahiro
authors: M
authors: Okuda
authors: Esteban C
authors: EC
authors: Gabazza
authors: Hitoshi
authors: H
authors: Mizutani
mesh_terms: D003876:Dermatitis, Atopic / Q000150:complications; D004311:Double-Blind Method; D004569:Electroencephalography; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use*; D006801:Humans; D000069605:Olopatadine Hydrochloride / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D012720:Severity of Illness Index; D012894:Sleep Stages / Q000502:physiology*; D013997:Time Factors; D064232:Visual Analog Scale
chemical_list: D039563:Histamine H1 Antagonists, Non-Sedating; D000069605:Olopatadine Hydrochloride
keywords: antihistamine; atopic dermatitis; electroencephalogram; scratching; sleep quality