title: Cascade catalysis--strategies and challenges en route to preparative synthetic biology.
abstract: Nature's smartness and efficient assembling cascade type reactions inspired biologists and chemists all around the world. Tremendous effort has been directed towards the understanding and mimicking of such networks. In recent years considerable progress has been made in developing multistep one-pot reactions combining either advantage of chemo-, regio-, and stereoselectivity of biocatalysts or promiscuity and productivity of chemocatalysts. In this context several concepts, inspired by different disciplines (biocatalysis, metabolic engineering, synthetic chemistry, and material science), have been evolved. This review will focus on major contributions in the field of cascade reactions over the last three years.
authors: Institute of Biochemistry, Dept. of Biotechnology & Enzyme Catalysis, Greifswald University, Felix-Hausdorff-Str. 4, 17489 Greifswald, Germany.
authors: Jan
authors: J
authors: Muschiol
authors: Christin
authors: C
authors: Peters
authors: Nikolin
authors: N
authors: Oberleitner
authors: Marko D
authors: MD
authors: Mihovilovic
authors: Uwe T
authors: UT
authors: Bornscheuer
authors: Florian
authors: F
authors: Rudroff
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D055162:Biocatalysis; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D060847:Metabolic Engineering / Q000379:methods*; D016297:Mutagenesis, Site-Directed; D010231:Paracoccus denitrificans / Q000201:enzymology / Q000235:genetics; D015202:Protein Engineering / Q000379:methods*; D058615:Synthetic Biology / Q000379:methods* / Q000639:trends
chemical_list: D001426:Bacterial Proteins