title: Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants.
abstract: OBJECTIVE
  To evaluate the prevalence of metabolic syndrome (MetS) and its association with physical capacity, disability, and self-rated health in older adults at high risk of mobility disability, including those with and without diabetes mellitus.
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Lifestyle Interventions and Independence for Elders (LIFE) Study.
  
  
  METHODS
  Community-dwelling sedentary adults aged 70 to 89 at high risk of mobility disability (Short Physical Performance Battery (SPPB) score ≤9; mean 7.4 ± 1.6) (N = 1,535).
  
  
  METHODS
  Metabolic syndrome was defined according to the 2009 multiagency harmonized criteria; outcomes were physical capacity (400-m walk time, grip strength, SPPB score), disability (composite 19-item score), and self-rated health (5-point scale ranging from excellent to poor).
  
  
  RESULTS
  The prevalence of MetS was 49.8% in the overall sample (83.2% of those with diabetes mellitus, 38.1% of those without). MetS was associated with stronger grip strength (mean difference (Δ) = 1.2 kg, P = .01) in the overall sample and in participants without diabetes mellitus and with poorer self-rated health (Δ = 0.1 kg, P < .001) in the overall sample only. No significant differences were found in 400-m walk time, SPPB score, or disability score between participants with and without MetS, in the overall sample or diabetes mellitus subgroups.
  
  
  CONCLUSIONS
  Metabolic dysfunction is highly prevalent in older adults at risk of mobility disability, yet consistent associations were not observed between MetS and walking speed, lower extremity function, or self-reported disability after adjusting for known and potential confounders. Longitudinal studies are needed to investigate whether MetS accelerates declines in functional status in high-risk older adults and to inform clinical and public health interventions aimed at preventing or delaying disability in this group.
authors: Department of Health Policy Studies, University of Michigan, Ann Arbor, Dearborn, Michigan; Institute of Gerontology, University of Michigan, Ann Arbor, Dearborn, Michigan; Division of Geriatrics, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut.
authors: Anda
authors: A
authors: Botoseneanu
authors: Walter T
authors: WT
authors: Ambrosius
authors: Daniel P
authors: DP
authors: Beavers
authors: Nathalie
authors: N
authors: de Rekeneire
authors: Stephen
authors: S
authors: Anton
authors: Timothy
authors: T
authors: Church
authors: Sara C
authors: SC
authors: Folta
authors: Bret H
authors: BH
authors: Goodpaster
authors: Abby C
authors: AC
authors: King
authors: Barbara J
authors: BJ
authors: Nicklas
authors: Bonnie
authors: B
authors: Spring
authors: Xuewen
authors: X
authors: Wang
authors: Thomas M
authors: TM
authors: Gill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006304:Health Status; D006801:Humans; D057187:Independent Living; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000503:physiopathology* / Q000523:psychology; D051346:Mobility Limitation; D015995:Prevalence; D012647:Self-Assessment
keywords: Short Physical Performance Battery; grip strength; metabolic syndrome; mobility disability; self-rated health
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