title: Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice.
abstract: Preliminary work by our research team revealed that Schisandra, a renowned traditional Chinese medicine, causes learning and memory improvements in ovariectomized mice. This activity was attributed to active ingredients extracted with N-butyl alcohol, named Schisandra N-butanol extract. In this study, ovariectomized mice were pretreated with Schisandra N-butanol extract given by intragastric administration. This treatment led to the enhancement of learning, and an increase in hippocampal CA1 synaptic, surface and postsynaptic density. A decrease in the average size of the synaptic active zone was also observed. These experimental findings showing that Schisandra N-butanol extract improved synaptic morphology indicate an underlying mechanism by which the ability of learning is enhanced in ovariectomized mice.
authors: School of Life Science, South China Normal University, Guangzhou 510631, Guangdong Province, China.
authors: Meiyan
authors: M
authors: Yang
authors: School of Life Science, South China Normal University, Guangzhou 510631, Guangdong Province, China.
authors: Zhaolin
authors: Z
authors: Cai
authors: School of Life Science, South China Normal University, Guangzhou 510631, Guangdong Province, China.
authors: Peng
authors: P
authors: Xiao
authors: School of Life Science, South China Normal University, Guangzhou 510631, Guangdong Province, China.
authors: Chuhua
authors: C
authors: Li
keywords: Schisandra N-butanol extract; behavioral learning; hippocampal CA1; mice; neural regeneration; ovariectomy; synaptic density; synaptic morphology
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