title: [Antioxidant use as dietary therapy in patients with multiple sclerosis].
abstract: BACKGROUND
  Multiple sclerosis is an immune-mediated disease that produces chronic inflammation and neural degeneration. The disease progresses with acute attacks that result in myelin inflammation. This in turn increases oxidative stress and favors the appearance of reactive oxygen species. Reactive oxygen species damage neural cells causing apoptosis. The etiology of multiple sclerosis remains unknown and current therapy is aggressive and expensive. Recently, complementary and alternative medicine therapies have been proposed to control pathogenesis and symptoms of this disease. It is believed that these therapies help slow the progression of multiple sclerosis and improve survival.
  
  
  METHODS
  We conducted a MEDLINE/PubMed search using the following MeSH terms: diet, multiple sclerosis, antioxidants. We selected the main articles containing multiple sclerosis and diet.
  
  
  RESULTS
  We analyzed three case control studies that evaluated different dietary approaches in multiple sclerosis. For this review, we also included five experimental studies that studied the efficacy of lipoic acid in humans and rodents in diseases like multiple sclerosis, experimental autoimmune encephalomyelitis, and breast cancer.
authors: Escuela de Nutrición, Universidad Latinoamericana, Cuernavaca, México. Address: Av. Universidad N°. 655, CP 62100, Cuernavaca, Morelos, México. Email: chernand@insp.mx.
authors: Laura
authors: L
authors: González-González
authors: Escuela de Nutrición, Universidad Latinoamericana, Cuernavaca, México.
authors: Jesús Giovanni
authors: JG
authors: Pérez-Cortéz
authors: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors: Mario
authors: M
authors: Flores-Aldana
authors: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors: Nayeli
authors: N
authors: Macías-Morales
authors: Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors: Carlos
authors: C
authors: Hernández-Girón
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D018450:Disease Progression; D006801:Humans; D009103:Multiple Sclerosis / Q000178:diet therapy* / Q000503:physiopathology; D009186:Myelin Sheath / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D008063:Thioctic Acid / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D008063:Thioctic Acid