title: Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
abstract: Recent studies have suggested that noncoding RNAs (ncRNAs) contribute to the pathogenesis and progression of hepatocellular carcinoma (HCC). These RNA genes may be involved in various pathobiological processes such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Aberrant expression of ncRNA resulting from deregulated epigenetic, transcriptional, or posttranscriptional activity has been described in several studies. ncRNAs are comprised of a highly diverse group of transcripts that include microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) as well as several other types of RNA genes. Understanding the molecular mechanisms by which ncRNA contribute to hepatocarcinogenesis may enable the design of ncRNA-based therapeutics for HCC. In this review, the authors provide a perspective on therapeutic applications based on the emerging evidence of a contributory role of miRNAs and lncRNAs to the pathogenesis and progression of HCC. In addition, ncRNAs that are deregulated in expression in HCC may have utility as potential prognostic or diagnostic markers.
authors: Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors: Joseph
authors: J
authors: George
authors: Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida.
authors: Tushar
authors: T
authors: Patel
mesh_terms: D017209:Apoptosis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000235:genetics; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
references: J Gastroenterol Hepatol. 2013 Mar;28(3):565-75
references: 22989374
references: Hepatogastroenterology. 2012 Nov-Dec;59(120):2367-73
references: 22773266
references: Curr Cancer Drug Targets. 2012 Nov 1;12(9):1073-80
references: 22873215
references: PLoS One. 2012;7(4):e35145
references: 22493738
references: Biomed Res Int. 2013;2013:136106
references: 23762823
references: Cancer Res. 2007 Jul 1;67(13):6092-9
references: 17616664
references: Science. 2005 Sep 2;309(5740):1559-63
references: 16141072
references: Biotechniques. 2013 Jun;54(6):301, 303-4
references: 23750541
references: J Med Virol. 2014 Mar;86(3):446-53
references: 24248733
references: World J Gastroenterol. 2014 May 28;20(20):5962-72
references: 24876719
references: DNA Cell Biol. 2014 Oct;33(10):715-22
references: 25050974
references: Tumour Biol. 2014 Aug;35(8):7775-80
references: 24816919
references: Gastroenterology. 2007 Jan;132(1):330-42
references: 17241883
references: Med Oncol. 2012 Sep;29(3):1810-6
references: 21678027
references: RNA. 2007 Jun;13(6):890-8
references: 17416635
references: Cell Signal. 2013 May;25(5):1037-43
references: 23376496
references: Hepatology. 2014 May;59(5):1874-85
references: 24259426
references: Hepatology. 2009 Jul;50(1):113-21
references: 19441017
references: Pathology. 2010 Dec;42(7):669-73
references: 21080878
references: Cancer Cell. 2014 May 12;25(5):666-81
references: 24768205
references: Gene. 2013 Jul 25;524(2):156-60
references: 23632240
references: PLoS One. 2012;7(1):e30585
references: 22291993
references: Diagn Pathol. 2014;9:47
references: 24593846
references: Clin Cancer Res. 2008 Jan 15;14(2):419-27
references: 18223217
references: Carcinogenesis. 2013 Jan;34(1):211-9
references: 23087084
references: PLoS One. 2013;8(3):e58586
references: 23520522
references: FEBS Open Bio. 2014 May 09;4:458-67
references: 24918061
references: Drug Alcohol Rev. 2010 Jul;29(4):437-45
references: 20636661
references: Asian Pac J Cancer Prev. 2011;12(11):3107-12
references: 22393998
references: Genome Res. 2012 Sep;22(9):1775-89
references: 22955988
references: N Biotechnol. 2013 May 25;30(4):381-4
references: 23392071
references: Front Genet. 2012 Oct 09;3:205
references: 23087702
references: Nat Genet. 2002 Aug;31(4):339-46
references: 12149612
references: Semin Oncol. 2011 Dec;38(6):752-63
references: 22082761
references: Hepatology. 2011 Nov;54(5):1679-89
references: 21769904
references: PLoS One. 2014;9(2):e88393
references: 24551096
references: Asian Pac J Cancer Prev. 2014;15(6):2565-70
references: 24761865
references: Hepatology. 2013 Aug;58(2):629-41
references: 23471579
references: Oncogene. 2007 Jul 19;26(33):4877-81
references: 17297456
references: Hepatology. 2011 Oct;54(4):1237-48
references: 21721029
references: Biochem Biophys Res Commun. 2013 Nov 29;441(4):873-9
references: 24211205
references: PLoS One. 2014;9(1):e85394
references: 24416400
references: J Surg Oncol. 2011 Feb;103(2):148-51
references: 21259248
references: Microrna. 2014;2(3):194-204
references: 25069443
references: PLoS One. 2012;7(2):e32230
references: 22393390
references: J Cell Sci. 2014 Apr 1;127(Pt 7):1585-94
references: 24463816
references: Int J Clin Exp Med. 2014 Apr 15;7(4):893-902
references: 24955159
references: Nat Methods. 2007 Sep;4(9):721-6
references: 17694064
references: Cancer Res. 2008 Jul 1;68(13):5049-58
references: 18593903
references: Nature. 2009 Mar 12;458(7235):223-7
references: 19182780
references: Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):678-85
references: 21565290
references: Cancer Lett. 2013 Oct 10;339(2):159-66
references: 23791884
references: Mol Biol Rep. 2012 Jun;39(6):7019-23
references: 22311030
references: Int J Oncol. 2013 Aug;43(2):661-9
references: 23708209
references: J Invest Surg. 2012 Jun;25(3):156-61
references: 22583011
references: Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19678-83
references: 19066217
references: Carcinogenesis. 2013 Sep;34(9):2071-9
references: 23671131
references: Mol Pathol. 1998 Feb;51(1):21-5
references: 9624415
references: Bioessays. 2010 Jun;32(6):473-80
references: 20486133
references: Clin Ther. 2010 Dec;32(13):2117-38
references: 21316532
references: Cancer Res. 2011 Dec 15;71(24):7608-16
references: 22009537
references: Cancer Epidemiol. 2014 Aug;38(4):408-13
references: 24923856
references: Cancer Sci. 2009 Jul;100(7):1234-42
references: 19486339
references: Genet Mol Res. 2014;13(3):5048-54
references: 25061729
references: Virchows Arch. 2008 Jan;452(1):1-10
references: 18040713
references: Annu Rev Pathol. 2014;9:287-314
references: 24079833
references: Hepatology. 2008 Apr;47(4):1223-32
references: 18307259
references: Hepatology. 2013 Aug;58(2):642-53
references: 23468064
references: Nature. 2012 Feb 16;482(7385):347-55
references: 22337054
references: Oncol Rep. 2013 Mar;29(3):946-50
references: 23292722
references: Nucleic Acids Res. 2010 Sep;38(16):5366-83
references: 20423907
references: Gut. 2012 Feb;61(2):278-89
references: 21672940
references: Hepatology. 2014 Aug;60(2):744-53
references: 24493213
references: Gastroenterology. 2009 Feb;136(2):683-93
references: 19027010
references: Oncol Lett. 2014 Sep;8(3):1255-1260
references: 25120701
references: Gland Surg. 2013 Feb;2(1):25-9
references: 25083452
references: Hepatology. 2014 Mar;59(3):911-23
references: 24114970
references: Int J Cancer. 2011 Jan 15;128(2):412-7
references: 20309940
references: J Int Med Res. 2011;39(6):2119-28
references: 22289527
references: Oncogene. 2010 Jun 17;29(24):3583-92
references: 20383195
references: J Cancer. 2012;3:19-31
references: 22211142
references: Hepatology. 2010 Mar;51(3):836-45
references: 20041405
references: Genes Cancer. 2013 Jul;4(7-8):261-72
references: 24167654
references: Hepatology. 2013 Nov;58(5):1703-12
references: 23728852
references: Cancer Epidemiol. 2013 Dec;37(6):998-1002
references: 24103425
references: J Biol Chem. 2012 Jul 27;287(31):26302-11
references: 22685290
references: J Clin Invest. 2012 Aug;122(8):2884-97
references: 22820290
references: Oncogene. 2007 Feb 8;26(6):851-8
references: 16878148
references: Hepatology. 2012 Jun;55(6):1852-62
references: 22234835
references: Med Oncol. 2014 Jun;31(6):984
references: 24805877
references: Mol Cell Pharmacol. 2011;3(3):83-92
references: 22468167
references: Oncogene. 2013 Jun 20;32(25):3071-9
references: 22824797
references: Nature. 2008 Sep 4;455(7209):58-63
references: 18668040
references: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):786-91
references: 21187392
references: Hepatology. 2011 May;53(5):1476-85
references: 21520166
references: Int J Cancer. 2008 Oct 1;123(7):1616-22
references: 18649363
references: Gene. 2014 Jan 1;533(1):456-7
references: 24084367
references: J Viral Hepat. 2011 Jul;18(7):e399-407
references: 21692953
references: FEBS Lett. 2011 Jul 21;585(14):2229-34
references: 21658389
references: Cancer Lett. 2009 Mar 8;275(1):44-53
references: 19006648
references: Tumour Biol. 2014 Aug;35(8):7587-94
references: 24793017
references: Gene. 2011 Oct 15;486(1-2):104-9
references: 21807077
references: Int J Mol Sci. 2014;15(3):4060-76
references: 24663081
references: PLoS One. 2012;7(11):e49462
references: 23145177
references: Oncogene. 2011 Nov 24;30(47):4750-6
references: 21625215
references: Genomics. 2012 Feb;99(2):76-80
references: 22210346
references: Hepatology. 2009 Oct;50(4):1152-61
references: 19711427
references: Cell Death Dis. 2014;5:e1287
references: 24922071
references: J Hepatol. 2012 Jun;56(6):1371-83
references: 22314424
references: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):264-9
references: 20018759
references: World J Gastroenterol. 2013 Nov 28;19(44):7836-45
references: 24307777
references: J Biol Chem. 2013 Jun 21;288(25):18484-93
references: 23649629
references: Br J Cancer. 2010 Nov 9;103(10):1617-26
references: 20978511
references: PLoS One. 2014;9(7):e103599
references: 25072345
references: Hepatology. 2012 Nov;56(5):1631-40
references: 22610915
references: Dig Liver Dis. 2012 Oct;44(10):849-54
references: 22658643
references: Semin Liver Dis. 2013 May;33(2):147-56
references: 23749671
references: Cancer Cell. 2011 Feb 15;19(2):232-43
references: 21316602
references: J Pathol. 2012 Jul;227(3):275-85
references: 22262409
references: Nat Rev Genet. 2011 Dec;12(12):861-74
references: 22094949
references: Hepatology. 2013 Mar;57(3):1055-67
references: 23079745
references: J Hepatol. 2014 Apr;60(4):792-801
references: 24333181
references: Int J Biochem Cell Biol. 2013 Aug;45(8):1895-910
references: 23748105
references: Science. 2010 Jan 8;327(5962):198-201
references: 19965718
references: Gastroenterology. 2007 Aug;133(2):647-58
references: 17681183
references: Ann Surg Oncol. 2011 May;18(5):1243-50
references: 21327457
references: PLoS One. 2013;8(7):e68588
references: 23935875
references: Cell. 2009 Jun 12;137(6):1005-17
references: 19524505
references: EMBO J. 2008 Dec 17;27(24):3300-10
references: 19020517
references: Carcinogenesis. 2013 Mar;34(3):577-86
references: 23222811
references: Oncogene. 2006 Apr 20;25(17):2537-45
references: 16331254
references: Cell Commun Signal. 2014;12:45
references: 25012758
references: Br J Cancer. 2013 Jun 25;108(12):2419-25
references: 23660942
references: Gene. 2014 Jun 10;543(1):101-7
references: 24704024
references: Molecules. 2014;19(5):6393-406
references: 24853455
references: Hepatology. 2012 Dec;56(6):2231-41
references: 22706893
references: Cancer Res. 2010 Jun 15;70(12):5184-93
references: 20501828
references: PLoS One. 2012;7(7):e41983
references: 22848681
references: Gene. 2012 Aug 1;504(1):92-7
references: 22583825
references: Cancer Lett. 2014 Mar 1;344(1):20-7
references: 24183851
references: Cancer Cell. 2007 Sep;12(3):215-29
references: 17785203
references: Clin Exp Metastasis. 2013 Jun;30(5):651-8
references: 23378255
references: Hepatol Res. 2014 May;44(5):551-559
references: 23621665
references: Oncol Rep. 2013 Nov;30(5):2203-10
references: 24009066
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Chin J Cancer Res. 2014 Jun;26(3):315-22
references: 25035659
references: Hepatology. 2013 Sep;58(3):1153-65
references: 23532995
references: Cancer Res. 2002 Jul 15;62(14):3939-44
references: 12124323
references: Clin Cancer Res. 2010 Feb 1;16(3):867-75
references: 20103675
references: Int J Cancer. 2013 Aug 15;133(4):816-24
references: 23390000
references: Gastroenterology. 2012 Sep;143(3):811-20.e1-15
references: 22641068
references: Hepatology. 2014 Sep;60(3):872-83
references: 24798303
references: Biochem Biophys Res Commun. 2014 Apr 18;446(4):1255-60
references: 24690171
references: Hepatology. 2008 Dec;48(6):1834-42
references: 18972404
references: Science. 2004 May 28;304(5675):1321-5
references: 15131266
references: Mol Carcinog. 2013 Apr;52(4):297-303
references: 22213236
references: Oncol Rep. 2014 Jan;31(1):358-64
references: 24247585
references: Nat Med. 2008 Nov;14(11):1271-7
references: 18931683
references: Nat Rev Genet. 2009 Mar;10(3):155-9
references: 19188922
references: Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29
references: 16651366
references: Oncol Lett. 2013 Dec;6(6):1811-1815
references: 24260081
references: AAPS J. 2009 Dec;11(4):747-57
references: 19876744