title: Roles of DNA Damage Response Proteins in Mitogen-Induced Thp-1 Differentiation into Macrophage.
abstract: ATM, ATR and DNA-PK are critical for DNA damage response (DDR) and sequential repair, leading to genomic stability. In this study, we found the expression of these proteins is markedly induced by PMA during THP1 differentiation without the change in the level of transcripts. Also, inhibitors of these protein activity suppressed PMA-induced morphological change of THP1 cells. Our results suggest the potential roles of these DDR proteins in cellular differentiation.
authors: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors: Eui Young
authors: EY
authors: So
authors: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors: Martin
authors: M
authors: Kozicki
authors: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors: Toru
authors: T
authors: Ouchi
keywords: Antigen presenting cells; DNA damage response; Severe combined immunodeficiency
references: J Biol Chem. 2006 Apr 7;281(14 ):9710-8
references: 16452482
references: Nature. 2004 Nov 18;432(7015):316-23
references: 15549093
references: Nucleic Acids Res. 2009 Sep;37(17 ):5678-89
references: 19625493
references: DNA Repair (Amst). 2010 Dec 10;9(12 ):1307-14
references: 21030321
references: Nat Genet. 1997 Dec;17(4):483-6
references: 9398856
references: Blood. 1999 Sep 15;94(6):1998-2006
references: 10477729
references: Blood. 2004 Jul 15;104(2):572-8
references: 15044255
references: Cell. 1996 Jul 12;86(1):159-71
references: 8689683
references: Am J Pathol. 2003 Aug;163(2):423-32
references: 12875964
references: Mol Cancer Ther. 2010 Jan;9(1):113-25
references: 20053781
references: Stem Cells. 2009 Aug;27(8):1987-98
references: 19544430
references: Nature. 2009 Oct 22;461(7267):1071-8
references: 19847258
references: Trends Cell Biol. 2011 May;21(5):312-9
references: 21354798