title: A multistrategic approach in the development of sourdough bread targeted towards blood pressure reduction.
abstract: Rising prevalence of hypertension is pushing food industry towards the development of innovative food products with antihypertensive effects. The aim was to study the effect of reduced sodium content and 21% addition of wholemeal wheat sourdough (produced by Lactobacillus brevis CECT 8183 and protease) on proximate composition, γ-aminobutyric acid (GABA) and peptide content of wheat bread. Angiotensin converting enzyme I (ACE) inhibitory and antioxidant activities were also evaluated. Sodium replacement by potassium salt did not affect chemical composition and biological activities of bread. In contrast, GABA and peptides <3 kDa contents in sourdough bread (SDB) were 7 and 3 times higher, respectively, than the observed in control. ACE inhibitory and antioxidant activities of the peptide fraction < 3 kDa from SDB was 1.7 and 2.6-3.0 times higher than control. Therefore, the combination of reduced sodium content with enriched concentrations of bioactive compounds in bread making may provide interesting perspectives for development of innovative breads towards blood pressure reduction.
authors: Department of Food Characterization, Quality and Safety, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
authors: E
authors: E
authors: Peñas
authors: M
authors: M
authors: Diana
authors: J
authors: J
authors: Frias
authors: J
authors: J
authors: Quílez
authors: C
authors: C
authors: Martínez-Villaluenga
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis; D000975:Antioxidants / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D001939:Bread / Q000032:analysis*; D005285:Fermentation; D005433:Flour / Q000032:analysis; D005511:Food Handling / Q000379:methods*; D010455:Peptides / Q000032:analysis / Q000494:pharmacology*; D017419:Potassium, Dietary / Q000494:pharmacology; D012982:Sodium, Dietary / Q000009:adverse effects*; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D010455:Peptides; D017419:Potassium, Dietary; D012982:Sodium, Dietary; D005680:gamma-Aminobutyric Acid
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