title: Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population.
abstract: Both genetic predisposition and lifestyle factors are associated with the risk for obesity. Multiple obesity loci have been identified using genome-wide association studies mainly in European populations. The aims of this study were to examine the associations of these loci with obesity and gene×dietary behavior interactions among Chinese children and adolescents. Nineteen candidate SNPs were genotyped using Sequenom technology in the Chinese children (N=2977, 853 obese and 2124 controls, aged 7-17). Dietary behaviors were assessed using self-administered questionnaires. After adjusting for age, sex and multiple testing, MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423 and KCTD15 rs11084753 were associated with obesity and obesity-related traits (all P<0.005), with odd ratios ranging from 1.22 to 2.15. Dose-response association was significant between genetic risk score, which was calculated by summing the risk alleles, and the risk of obesity (P<0.001). Multiplicative interaction was found between rs543874 and salt preference on obesity with an OR of 4.40 (95% CI, 1.12-17.30). Additive interactions with salt preference were found in rs17782313 and rs11084753. Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity.
authors: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors: Duo
authors: D
authors: Lv
authors: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors: Dan-Dan
authors: DD
authors: Zhang
authors: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors: Hao
authors: H
authors: Wang
authors: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors: Yan
authors: Y
authors: Zhang
authors: Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Li
authors: L
authors: Liang
authors: Department of Endocrinology, Children's Hospital of College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Jun-Fen
authors: JF
authors: Fu
authors: Department of Endocrinology, Children's Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China.
authors: Feng
authors: F
authors: Xiong
authors: Department of Pediatrics, General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors: Ge-Li
authors: GL
authors: Liu
authors: Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
authors: Chun-Xiu
authors: CX
authors: Gong
authors: Department of Pediatric Endocrinology and Inborn Metabolic Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
authors: Fei-Hong
authors: FH
authors: Luo
authors: Department of Pediatrics Endocrinology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China.
authors: Shao-Ke
authors: SK
authors: Chen
authors: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors: Zhen-Li
authors: ZL
authors: Li
authors: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China. Electronic address: zhuym@zju.edu.cn.
authors: Yi-Min
authors: YM
authors: Zhu
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D048671:MAP Kinase Kinase 5 / Q000235:genetics*; D008297:Male; D063766:Pediatric Obesity / Q000235:genetics*; D015221:Potassium Channels / Q000235:genetics*; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012306:Risk
chemical_list: D004268:DNA-Binding Proteins; C552182:KCTD15 protein, human; C470072:MC4R protein, human; D015221:Potassium Channels; D044105:Receptor, Melanocortin, Type 4; C443860:SEC16B protein, human; D048671:MAP Kinase Kinase 5; C482563:MAP2K5 protein, human
keywords: Child; Gene–dietary behavior interaction; Obesity; Polymorphisms