title: Cell of origin for malignant gliomas and its implication in therapeutic development.
abstract: Malignant glioma remains incurable despite tremendous advancement in basic research and clinical practice. The identification of the cell(s) of origin should provide deep insights into leverage points for one to halt disease progression. Here we summarize recent studies that support the notion that neural stem cell (NSC), astrocyte, and oligodendrocyte precursor cell (OPC) can all serve as the cell of origin. We also lay out important considerations on technical rigor for further exploring this subject. Finally, we share perspectives on how one could apply the knowledge of cell of origin to develop effective treatment methods. Although it will be a difficult battle, victory should be within reach as along as we continue to assimilate new information and facilitate the collaboration among basic scientists, translational researchers, and clinicians.
authors: Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908.
authors: Hui
authors: H
authors: Zong
authors: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
authors: Luis F
authors: LF
authors: Parada
authors: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
authors: Suzanne J
authors: SJ
authors: Baker
mesh_terms: D001253:Astrocytes / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy*; D005910:Glioma / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D058953:Neural Stem Cells / Q000473:pathology; D009836:Oligodendroglia / Q000473:pathology
references: J Neurosci. 2006 Jun 21;26(25):6781-90
references: 16793885
references: EMBO J. 2010 Jan 6;29(1):222-35
references: 19927122
references: Cancer Cell. 2011 Mar 8;19(3):305-16
references: 21397855
references: J Neuropathol Exp Neurol. 2012 Aug;71(8):729-40
references: 22805776
references: Nature. 2012 Aug 23;488(7412):522-6
references: 22854781
references: J Neurobiol. 2001 Aug;48(2):75-86
references: 11438938
references: Brain Pathol. 2010 Mar;20(2):399-411
references: 19486010
references: Transl Oncol. 2009 May;2(2):89-95
references: 19412424
references: Glia. 2000 Apr;30(2):105-21
references: 10719353
references: Nat Rev Neurosci. 2004 May;5(5):409-19
references: 15100723
references: Cancer Res. 2013 Oct 15;73(20):6219-29
references: 23970477
references: Brain Res Bull. 2002 Apr;57(6):751-8
references: 12031271
references: Nat Neurosci. 2005 Jun;8(6):723-9
references: 15908947
references: Cancer Cell. 2005 Aug;8(2):119-30
references: 16098465
references: EMBO J. 1984 Aug;3(8):1857-64
references: 6541124
references: J Comp Neurol. 1978 Jul 1;180(1):115-28, 132-7
references: 649784
references: Acta Neuropathol. 2008 Nov;116(5):465-77
references: 18784926
references: Dev Biol. 1997 Aug 1;188(1):48-63
references: 9245511
references: Expert Rev Mol Diagn. 2012 May;12(4):383-94
references: 22616703
references: Cancer Res. 2011 Jun 15;71(12 ):4106-16
references: 21507933
references: Nat Neurosci. 2013 May;16(5):580-6
references: 23542688
references: J Neuropathol Exp Neurol. 2004 May;63(5):499-509
references: 15198128
references: Neuron. 2007 Feb 15;53(4):503-17
references: 17296553
references: Neuron. 2005 May 5;46(3):369-72
references: 15882633
references: Science. 2008 Sep 26;321(5897):1807-12
references: 18772396
references: Neuron. 1994 May;12(5):935-42
references: 8185952
references: Neuron. 2011 May 26;70(4):687-702
references: 21609825
references: Science. 2014 Jun 20;344(6190):1396-401
references: 24925914
references: Cancer Cell. 2012 Jan 17;21(1):11-24
references: 22264785
references: Cell. 1999 Jun 11;97(6):703-16
references: 10380923
references: J Neurosci Res. 1997 Mar 1;47(5):455-70
references: 9067855
references: Int J Dev Neurosci. 2001 Jul;19(4):379-85
references: 11378298
references: Nat Genet. 2000 May;25(1):55-7
references: 10802656
references: Science. 2000 Feb 25;287(5457):1433-8
references: 10688783
references: Genes Dev. 2001 Jun 1;15(11):1311-33
references: 11390353
references: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6
references: 19196966
references: Stem Cells. 2009 Oct;27(10):2373-82
references: 19544474
references: Cell. 1985 Aug;42(1):61-9
references: 4016955
references: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13883-8
references: 11095732
references: Cancer Cell. 2010 Dec 14;18(6):669-82
references: 21156288
references: PLoS One. 2013;8(2):e56691
references: 23424671
references: Nature. 2012 Mar 28;484(7394):376-80
references: 22456708
references: Nature. 1983 Jun 2-8;303(5916):390-6
references: 6304520
references: Cancer Res. 2004 Nov 1;64(21):7773-9
references: 15520182
references: Science. 2000 Sep 8;289(5485):1754-7
references: 10976069
references: Nat Rev Cancer. 2002 Aug;2(8):616-26
references: 12154354
references: Cancer Cell. 2006 May;9(5):391-403
references: 16697959
references: Nat Rev Neurosci. 2009 Jan;10(1):9-22
references: 19096367
references: Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14378-83
references: 23942126
references: Oncogene. 2009 Jun 11;28(23):2266-75
references: 19421151
references: Cancer Cell. 2002 Apr;1(3):269-77
references: 12086863
references: Nature. 2011 Jan 20;469(7330):314-22
references: 21248838
references: J Neurosci. 2006 Oct 25;26(43):10967-83
references: 17065439
references: Curr Opin Neurobiol. 2012 Oct;22(5):844-9
references: 22560511
references: Nat Rev Cancer. 2013 Oct;13(10):714-26
references: 24060863
references: PLoS One. 2008 Apr 09;3(4):e1936
references: 18398462
references: Glia. 2013 Nov;61(11):1862-72
references: 24038521
references: Cancer Res. 1998 Dec 1;58(23):5275-9
references: 9850047
references: Nature. 2008 Oct 23;455(7216):1061-8
references: 18772890
references: J Neurosci. 2008 Jan 2;28(1):264-78
references: 18171944
references: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10851-6
references: 11526205
references: Cancer Res. 2003 Apr 1;63(7):1589-95
references: 12670909
references: N Engl J Med. 2005 Aug 25;353(8):811-22
references: 16120861
references: Neuroscientist. 2007 Feb;13(1):62-76
references: 17229976
references: N Engl J Med. 2009 Feb 19;360(8):765-73
references: 19228619
references: Neuron. 2011 Sep 8;71(5):799-811
references: 21903074
references: Development. 2008 Jan;135(1):145-57
references: 18045844
references: PLoS One. 2011;6(5):e20041
references: 21625383
references: Mol Cell Neurosci. 2003 Oct;24(2):476-88
references: 14572468
references: Development. 1989 Feb;105(2):387-400
references: 2680425
references: Nature. 1986 Feb 6-12;319(6053):499-502
references: 3945333
references: Cell. 2011 Jul 22;146(2):209-21
references: 21737130
references: J Neurosci. 2008 Oct 8;28(41):10434-42
references: 18842903
references: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10361-6
references: 10468613
references: J Clin Invest. 2011 Mar;121(3):905-17
references: 21393858
references: Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17933-8
references: 24114272
references: Genes Dev. 2012 May 1;26(9):891-907
references: 22549954
references: Nat Rev Genet. 2001 Feb;2(2):120-9
references: 11253051
references: Cancer Cell. 2009 Jan 6;15(1):45-56
references: 19111880
references: Neuron. 2008 Nov 6;60(3):430-40
references: 18995817
references: Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4495-500
references: 17360552
references: Cell. 2005 May 6;121(3):479-92
references: 15882628
references: Cancer Cell. 2010 Jan 19;17(1):98-110
references: 20129251
references: Genes Dev. 2001 Aug 1;15(15):1913-25
references: 11485986
references: Nat Med. 2003 Apr;9(4):439-47
references: 12627226
references: N Engl J Med. 2005 Mar 10;352(10 ):987-96
references: 15758009