title: Bone healing at implants with different surface configurations: an experimental study in dogs.
abstract: OBJECTIVE
  To study osseointegration of implants with surface modifications by the use of fluoroboric acid and/or H2 O2 installed in conventional sites or sites with circumferential marginal defects.
  
  
  METHODS
  Four implants with different surfaces were used. One basic surface (ZirTi(®)) was sandblasted with zirconium microspheres and acid etched additionally with hydrofluoric acid. A second surface was treated with fluoroboric acid instead of hydrofluoric acid. The remainder of the other two surfaces was additionally treated with H2O2. The edentulous mandibles of 6 foxhound dogs were used to randomly install 8.5-mm-long implants with the different surfaces and to study the histological healing after 1 and 3 months. To study osteoconductivity, additional four recipient sites were prepared with the coronal region being widened so that a 4 mm deep and 0.85 mm wide marginal defect resulted after the placement of the four implants with different surfaces. No filler material or membranes were used, and a fully submerged healing was allowed for 3 months.
  
  
  RESULTS
  At the conventional sites, new bone formation ranged between 68.5% and 74.9% after 1 month. After 3 months, bone-to-implant contact ranged from 72.6% at the ZirTi(®) surface to 84.1% at the fluoroboric acid-treated implants, the difference being statistically significant. At the sites with marginal defects, bone formation ranged from 0.77 mm at the surface treated with fluoroboric acid and H2O2 , to 1.93 mm at the surface treated with fluoroboric acid alone.
  
  
  CONCLUSIONS
  Fluoroboric acid treatment alone of titanium implant surfaces resulted in improved osseointegration and osteoconductivity after 3 months.
authors: Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
authors: Marco
authors: M
authors: Beolchini
authors: University of Zurich, Switzerland and University of Bern, Bern, Switzerland.
authors: Niklaus P
authors: NP
authors: Lang
authors: Faculty of Dentistry, University of Granada, Granada, Spain.
authors: Gerardo
authors: G
authors: Gómez Moreno
authors: Faculty of Dentistry, University of Chieti, Italy.
authors: Giovanna
authors: G
authors: Iezzi
authors: Faculty of Dentistry, University of Medical Science, La Habana, Cuba.|Faculdade de Odontologia de Araçatuba, (SP-Brasil) UNESP - Universidade Estadual Paulista & ARDEC, Ariminum Odontologica, Rimini, Italy.
authors: Daniele
authors: D
authors: Botticelli
authors: Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors: José Luis
authors: JL
authors: Calvo Guirado
mesh_terms: D000134:Acid Etching, Dental; D000818:Animals; D001881:Borates; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D008334:Mandible / Q000601:surgery; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D011897:Random Allocation; D013499:Surface Properties; D014025:Titanium; D014945:Wound Healing / Q000502:physiology*; D015040:Zirconium
chemical_list: D001881:Borates; D015921:Dental Implants; D015040:Zirconium; D014025:Titanium; C098759:fluoroboric acid; C028541:zirconium oxide
keywords: E.R.E.; Implant dentistry; animal study; bone augmentation; bone healing; bone width; buccal bony plate; dental implants; histology; ridge expansion; split crest