title: A time to kill: targeting apoptosis in cancer.
abstract: The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.
authors: Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. jkoff@emory.edu.
authors: Jean L
authors: JL
authors: Koff
authors: Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. sramac2@emory.edu.
authors: Sampath
authors: S
authors: Ramachandiran
authors: Department of Hematology and Medical Oncology at the Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA. lbernal@emory.edu.
authors: Leon
authors: L
authors: Bernal-Mizrachi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D020169:Caspases
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