title: Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology.
abstract: In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.
authors: Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of medicine, Laval University, 2705 Laurier Boulevard, QC G1V 4G2, Canada.
authors: Jean-Philippe
authors: JP
authors: Michaud
authors: Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of medicine, Laval University, 2705 Laurier Boulevard, QC G1V 4G2, Canada. Electronic address: serge.rivest@crchudequebec.ulaval.ca.
authors: Serge
authors: S
authors: Rivest
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D003072:Cognition Disorders / Q000378:metabolism*; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007162:Immunoproteins / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000172:deficiency*; D008297:Male; D058225:Plaque, Amyloid / Q000378:metabolism*; D057165:Proteostasis Deficiencies / Q000378:metabolism*
chemical_list: D016564:Amyloid beta-Protein Precursor; C508609:IL10 protein, human; C556062:IL10 protein, mouse; D007162:Immunoproteins; D016753:Interleukin-10