title: Body height, mobility, and risk of first and recurrent venous thrombosis.
abstract: BACKGROUND
  Tall people have an increased risk of a first venous thrombosis. Sedentary lifestyle has been shown to act synergistically with body height, especially during long-haul flights.
  
  
  OBJECTIVE
  To estimate the relation between height and risk of a first and recurrent venous thrombosis and a possible additional association with a mobile or an immobile lifestyle.
  
  
  METHODS
  Patients with a first venous thrombosis and control subjects were included between 1999 and 2004 (MEGA case-control study). Patients were followed for recurrence for an average time of 5.1 years (MEGA follow-up study). Odds ratios and hazard ratios (HRs) per increase of 5 cm were calculated compared with a height of 165-170 cm, separately and in combination with (im)mobility.
  
  
  RESULTS
  In 4464 patients who reported their height, we found an increasing risk of a first and recurrent event with height. For men, a 2.9-fold (95% confidence interval [CI] 1.9-4.4) increased risk for first venous thrombosis was found for those between 195 and 200 cm and a 3.8-fold (95% CI 1.5-9.8) higher risk for those > 200 cm compared with the reference category. For recurrence risk, the HRs were 1.7 (95% CI 0.8-3.3) and 3.7 (95% CI 1.4-10.0), respectively. For women, a 1.5-fold (95% CI 0.7-3.4) and 3-fold (95% CI 0.9-9.4) increased risk was found for those > 185 cm for first and recurrent venous thrombosis, respectively. For the tallest men and women, a slight additionally increased risk was observed for sedentary lifestyle.
  
  
  CONCLUSIONS
  Tall men and women have an increased risk of first and recurrent venous thrombosis, possibly higher in combination with a sedentary lifestyle.
authors: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
authors: L E
authors: LE
authors: Flinterman
authors: A
authors: A
authors: van Hylckama Vlieg
authors: F R
authors: FR
authors: Rosendaal
authors: S C
authors: SC
authors: Cannegieter
mesh_terms: D000328:Adult; D000368:Aged; D001827:Body Height; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009426:Netherlands; D016017:Odds Ratio; D016016:Proportional Hazards Models; D012008:Recurrence; D012307:Risk Factors; D057185:Sedentary Behavior; D012737:Sex Factors; D013997:Time Factors; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000209:etiology*
keywords: body height; life style; recurrence; risk; venous thrombosis