title: Multifocal electroretinogram in birdshot chorioretinopathy.
abstract: OBJECTIVE
  To characterize multifocal electroretinogram parameters in patients with birdshot chorioretinopathy.
  
  
  METHODS
  Twenty-eight patients with birdshot chorioretinopathy consecutively included from 2006 to 2011 were matched to 27 healthy subjects for age, axial length, and lens status. Multifocal electroretinogram was prospectively evaluated using the Vision Monitor system.
  
  
  RESULTS
  Birdshot chorioretinopathy eyes differed significantly from healthy eyes by a decrease in mean root mean square values (-24.7%), P1 (-17.3%) and N2 (-27.5%) amplitude, and the P1/N1 ratio (-26.3%) as well as an increase in N1 (8.7%) and P1 (5.4%) implicit time (IT). An effect of the degree of eccentricity (5 zones) was found for root mean square (P < 0.001), P1 (P < 0.001) and N2 (P < 0.001) amplitude, and P1 IT (P < 0.001). Root mean square, the P1/N1 ratio, P1 and N2 amplitudes, P1 and N1 ITs were significantly correlated with visual acuity, mean defect of visual field, foveal threshold, and color vision score. The fluorescein angiographic score was significantly correlated to N1 and N2 amplitudes and N1 IT.
  
  
  CONCLUSIONS
  Amplitudes and ITs of the multifocal electroretinogram parameters are impaired in patients with birdshot chorioretinopathy and are well correlated with other anatomical and functional tests. Periodic testing could guide the immunosuppressive treatment.
authors: *Department of Ophthalmology, University Hospital, Grenoble, France; †UJF-Grenoble 1, Grenoble, France; ‡Quality of Care Unit, Grenoble University Hospital, France; and §Clinical Research Center, CHU de Grenoble, Grenoble, France.
authors: Christophe
authors: C
authors: Chiquet
authors: Sylvie
authors: S
authors: Berthemy-Pellet
authors: Joséphine
authors: J
authors: Altayrac-Bethenod
authors: Florent
authors: F
authors: Aptel
authors: José
authors: J
authors: Labarere
authors: Jean-Louis
authors: JL
authors: Quesada
authors: Mathilde
authors: M
authors: Gallice
authors: Matthieu
authors: M
authors: Tonini
authors: Hafide
authors: H
authors: Khayi
authors: Jean-Paul
authors: JP
authors: Romanet
mesh_terms: D000368:Aged; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000503:physiopathology*; D003117:Color Vision Defects / Q000503:physiopathology; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology