title: Effects of a single, high oral dose of 25-hydroxycholecalciferol on the mineral metabolism markers in hemodialysis patients.
abstract: Vitamin D deficiency is common in dialysis patients with chronic kidney disease. Low levels have been associated with increased cardiovascular risk and mortality. We evaluated the administration of a high, single oral dose of 25-OH cholecalciferol (3 mg of Hidroferol, 180 000 IU) in patients on chronic hemodialysis. The 94 chronic hemodialysis patients with vitamin D deficiency 25 (OH)D <30 ng/mL included in the study were randomized into two groups. Follow-up time was 16 weeks. Neither the usual treatment for controlling Ca/P levels nor the dialysis bath (calcium of 2.5 mEq/L) were modified. Of the 86 patients who finished the study, 42 were in the treated group and 44 in the control group. An increase in 25(OH)D levels was observed in the treated group that persisted after 16 weeks and was associated with a significant decrease in parathyroid hormone (PTH) levels during the 8 weeks post-treatment. Baseline 1,25(OH)2 D levels of the treated group increased two weeks after treatment (5.9 vs. 21.9 pg/mL, P<0.001) but gradually reduced to 8.4 at week 16. The administration of a single 3 mg dose of 25-OH cholecalciferol seems safe in patients on hemodialysis and maintains sufficient levels of 25(OH)D with a decrease in PTH for 3 months.
authors: Section of Nephrology, Hospital Universitario del Henares, Madrid, Spain.
authors: Jose Luis
authors: JL
authors: Merino
authors: Department of Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors: Jose Luis
authors: JL
authors: Teruel
authors: Department of Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors: Milagros
authors: M
authors: Fernández-Lucas
authors: Department of Biochemistry, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors: Juan José
authors: JJ
authors: Villafruela
authors: Section of Nephrology, Hospital Universitario del Henares, Madrid, Spain.
authors: Blanca
authors: B
authors: Bueno
authors: Department of Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors: Antonio
authors: A
authors: Gomis
authors: Section of Nephrology, Hospital Universitario del Henares, Madrid, Spain.
authors: Vicente
authors: V
authors: Paraíso
authors: Department of Nephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors: Carlos
authors: C
authors: Quereda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002112:Calcifediol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000209:etiology
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D014807:Vitamin D; D002112:Calcifediol
keywords: 25 (OH) Vitamin D; Cholecalciferol; Hemodialysis; Parathyroid hormone