title: Diastolic dysfunction characterizes cirrhotic cardiomyopathy.
abstract: OBJECTIVE
  Present study aims to study the occurrence of cirrhotic cardiomyopathy and its correlation to hepatorenal syndrome by assessing the cardiac status in patients with cirrhosis of liver and healthy controls.
  
  
  METHODS
  Thirty alcoholic cirrhotic, thirty non-alcoholic cirrhotic and thirty controls were enrolled for the study. Cardiac parameters were assessed by color doppler echocardiography. Patients were followed up for twelve months period for development of hepatorenal syndrome.
  
  
  RESULTS
  Mild diastolic dysfunction was present in 18 cirrhotic patients (30%): grade I in fifteen patients and grade II in three. Diastolic dysfunction was unrelated to age; sex and etiology of cirrhosis. Among all the echocardiographic parameters, only deceleration time was found to be statistically significant. Echocardiographic parameters in systolic and diastolic function were not different in compensated vs decompensated patients in different Child-Pugh classes or cirrhosis aetiologies. At one year follow-up, no significant differences were found in survival between patients with or without diastolic dysfunction. Hepatorenal syndrome developed in only two patients and its correlation with diastolic dysfunction was not statistically significant.
  
  
  CONCLUSIONS
  Present study shows that although diastolic dysfunction is a frequent event in cirrhosis, it is usually of mild degree and does not correlate with severity of liver dysfunction. There are no significant differences in echocardiographic parameters between alcoholic and non-alcoholic cirrhosis. HRS is not correlated to diastolic dysfunction in cirrhotic patients. There is no difference in survival at one year between patients with or without diastolic dysfunction. Diastolic dysfunction in cirrhosis is unrelated to circulatory dysfunction, ascites and HRS.
authors: Lecturer, Department of Gastroenterology, BYL Nair Ch Hospital & Topiwala National Medical College, Dr A L Nair Road, Mumbai Central, Mumbai, Maharashtra 400008, India. Electronic address: dr_piyushsomani@yahoo.co.in.
authors: Piyush O
authors: PO
authors: Somani
authors: Associate Professor, Department of Gastroenterology, BYL Nair Ch Hospital & Topiwala National Medical College, Dr A L Nair Road, Mumbai Central, Mumbai, Maharashtra 400008, India.
authors: Qais
authors: Q
authors: Contractor
authors: Professor and Head, Department of Cardiology, BYL Nair Ch Hospital & Topiwala National Medical College, Dr A L Nair Road, Mumbai Central, Mumbai, Maharashtra 400008, India.
authors: Ajay S
authors: AS
authors: Chaurasia
authors: Professor and Head, Department of Gastroenterology, BYL Nair Ch Hospital & Topiwala National Medical College, Dr A L Nair Road, Mumbai Central, Mumbai, Maharashtra 400008, India.
authors: Pravin M
authors: PM
authors: Rathi
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D003971:Diastole; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
keywords: Cardiomyopathy; Cirrhosis; Cirrhotic cardiomyopathy; Diastolic dysfunction
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