title: Chemerin and prediction of Diabetes mellitus type 2.
abstract: OBJECTIVE
  Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM.
  
  
  METHODS
  Blood samples of 440 participants of the Metabolic-Syndrome Berlin-Potsdam (MesyBepo) follow-up study without diabetes at baseline were available for chemerin measurement. Mean follow-up of participants was 5·3 years. Glucose metabolism was analysed using oral glucose tolerance test including insulin measurements. Chemerin was measured using a commercially available ELISA.
  
  
  RESULTS
  Thirty-five individuals developed T2DM during follow-up. Chemerin predicted incident T2DM (Chemerin 1. Tertile: reference, 2. Tertile: OR 2·33 [0·68-7·95]; Chemerin 3. Tertile: OR 3·42 [1·01-11·58] after adjustment for age, sex, BMI, follow-up time, HbA1c, HOMA-IR and WHR). In a secondary analysis, chemerin also predicted worsening of fasting glucose and HbA1c (adjusted for age, sex, BMI, time of follow-up, WHR, HDL cholesterol and triglycerides).
  
  
  CONCLUSIONS
  Our data suggest that chemerin is a weak predictor of T2DM.
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Thomas
authors: T
authors: Bobbert
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Charité Center for cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Franziska
authors: F
authors: Schwarz
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Charité Center for cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Berlin, Germany.|Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Zentrum, Berlin-Buch, Germany.
authors: Antje
authors: A
authors: Fischer-Rosinsky
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Charité Center for cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Berlin, Germany.|Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Zentrum, Berlin-Buch, Germany.
authors: Lukas
authors: L
authors: Maurer
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Matthias
authors: M
authors: Möhlig
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Department of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany.
authors: A F H
authors: AF
authors: Pfeiffer
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Zentrum, Berlin-Buch, Germany.
authors: Knut
authors: K
authors: Mai
authors: Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Berlin, Germany.|Charité Center for cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Berlin, Germany.|Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Zentrum, Berlin-Buch, Germany.
authors: Joachim
authors: J
authors: Spranger
mesh_terms: D015992:Body Mass Index; D018925:Chemokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D005951:Glucose Tolerance Test / Q000379:methods; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D018925:Chemokines; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human