title: Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals.
abstract: Blood vessels are continuously exposed to various stresses such as mechanical strains and neurosignals. Besides its role as a barrier between blood and other tissues, the endothelium is a highly important cell layer for the regulation of vascular tone. Indeed, depending on the signal perceived by endothelial cells, it can drive a vasoconstrictor or vasodilator signal. This review presents mechano-receptors and neuro-receptors (restricted to neuropeptides) leading to vessel relaxation via the production of nitric oxide. Finally, some pieces of evidence of a potential cross-talk between these two kinds of stimuli are discussed.
authors: Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France; BioSciences Master, Department of Biology, Ecole Normale Supérieure de Lyon, University Lyon 1, Lyon, France.
authors: Alfred
authors: A
authors: Quillon
authors: Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France.
authors: Bérengère
authors: B
authors: Fromy
authors: Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), UMR5305 CNRS, University Lyon 1, Lyon, France. Electronic address: romain.debret@ibcp.fr.
authors: Romain
authors: R
authors: Debret
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008465:Mechanoreceptors; D051379:Mice; D008954:Models, Biological; D009569:Nitric Oxide; D011984:Sensory Receptor Cells; D015398:Signal Transduction; D014664:Vasodilation
chemical_list: D009569:Nitric Oxide
keywords: Endothelial nitric oxide synthase; Endothelium; Mechanosensing; Neurosensing; Vasodilation