title: The role of ERBB2 gene polymorphisms in leprosy susceptibility.
abstract: Mycobacterium leprae infects skin and peripheral nerves causing deformities and disability. The M. leprae bacterium binds to ErbB2 on the Schwann cell surface causing demyelination and favoring spread of the bacilli and causing nerve injury. Polymorphisms at the ERBB2 gene were previously investigated as genetic risk factors for leprosy in two Brazilian populations but with inconsistent results. Herein we extend the analysis of ERBB2 variants to a third geographically distinct population in Brazil. Our results show that there is no association between the genotyped SNPs and the disease (p>0.05) in this population. A gene set or pathway analysis under the genomic region of ERBB2 will be necessary to clarify its regulation under M. leprae stimulus.
authors: Universidade Federal da Bahia, Salvador, BA, Brazil. Electronic address: jamileao@hotmail.com.
authors: Jamile Leão
authors: JL
authors: Rêgo
authors: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors: Joyce Moura
authors: JM
authors: Oliveira
authors: Universidade Federal da Bahia, Salvador, BA, Brazil.
authors: Nadja de Lima
authors: Nde L
authors: Santana
authors: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Brazil; Universidade Federal da Bahia, Salvador, BA, Brazil.
authors: Paulo Roberto Lima
authors: PR
authors: Machado
authors: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Brazil; Universidade Federal da Bahia, Salvador, BA, Brazil.
authors: Léa Cristina
authors: LC
authors: Castellucci
mesh_terms: D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007918:Leprosy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012583:Schwann Cells / Q000382:microbiology*
keywords: ERBB2; Gene analysis; Leprosy
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