title: Miltiorins A-D, diterpenes from Radix Salviae miltiorrhizae.
abstract: Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes. The structures of 1-4 were assigned by spectroscopic analysis. Miltiorins A-C (1-3) were abietane diterpenes possessing a 2α-acetoxy group and a 12-hydroxy group in common, while miltiorin D (4) was a 11,12-seco-abietane diterpene with a γ-lactone ring. Miltiorin D (4) is the first example of a 11,12-seco-abietane diterpene from natural sources. Anti-NA activities of the isolated diterpenes were evaluated.
authors: Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
authors: Ai
authors: A
authors: Hirata
authors: Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan; Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Tobetsu 061-0293, Japan.
authors: Sang-Yong
authors: SY
authors: Kim
authors: Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
authors: Natsuki
authors: N
authors: Kobayakawa
authors: Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
authors: Naonobu
authors: N
authors: Tanaka
authors: Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan. Electronic address: kasiwada@tokushima-u.ac.jp.
authors: Yoshiki
authors: Y
authors: Kashiwada
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000998:Antiviral Agents; D010936:Plant Extracts; D009439:Neuraminidase
keywords: Anti-influenza; Diterpene; Miltiorins A–D; Radix Salviae miltiorrhizae