title: The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn.
abstract: We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 µM.
authors: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia. Electronic address: fatma@chem.its.ac.id.
authors: Sri
authors: S
authors: Fatmawati
authors: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.
authors: Taslim
authors: T
authors: Ersam
authors: Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors: Kuniyoshi
authors: K
authors: Shimizu
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D029762:Garcinia mangostana / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D044004:Xanthones / Q000494:pharmacology*
chemical_list: C114655:3-isomangostin; D004791:Enzyme Inhibitors; D044004:Xanthones; D000449:Aldehyde Reductase
keywords: Aldose reductase; Diabetic complications; Garcinia mangostana; Mangostin; Xanthone