title: Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D.
abstract: Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (Ker-Gawl.) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2-methylanthraquinone (5), icosyl ferulate (6), pustuline (7), 1,6-dihydroxy-2-methylanthranquinone (8), 6-hydroxy-2-methylanthraquinone (9), 7-hydroxy-2-methylanthraquinone (10), tyrosol (11), halleridone (12), calceolarioside B (13), and cornoside (14). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4, and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC-62, 786-0 and OVCAR-3 cell lines, with IC50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non-cancer cell line HaCat (human keratinocyte).
authors: Department of Chemistry, Federal University of Paraná, Curitiba, PR, 81531-980, Brazil, (phone: +55-41-33613177; fax: +55-41-33613186). mhelenaverdan@gmail.com.
authors: Maria Helena
authors: MH
authors: Verdan
authors: Lauro
authors: L
authors: Mera de Souza
authors: João
authors: J
authors: Ernesto de Carvalho
authors: Débora B
authors: DB
authors: Vendramini Costa
authors: Marcos José
authors: MJ
authors: Salvador
authors: Andersson
authors: A
authors: Barison
authors: Maria Élida
authors: MÉ
authors: Alves Stefanello
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones; C552224:aggregatin D
keywords: Anthraquinones; Cytotoxic activity; Naphthoquinones; Sinningia aggregata