title: Preparation of tetrasubstituted olefins using mono or double aerobic direct C-H functionalization strategies: importance of steric effects.
abstract: A novel protocol for the synthesis of tetrasubstituted olefins through a biomimetic approach has been explored. Both mono- and diarylations were performed under ambient oxygen pressure, giving a range of highly hindered tetrasubstituted alkenes. For diarylation of disubstituted substrates, it was demonstrated that the second arylation is the rate-limiting step of the overall transformation.
authors: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
authors: Nicolas
authors: N
authors: Gigant
authors: François
authors: F
authors: Quintin
authors: Jan-E
authors: JE
authors: Bäckvall
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics / Q000379:methods*; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*
chemical_list: D000475:Alkenes; D010100:Oxygen
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