title: Hazardous air pollutants and breast cancer risk in California teachers: a cohort study.
abstract: BACKGROUND
  Studies suggest that higher breast cancer rates in urban areas persist after accounting for the prevalence of known risk factors, leading to speculation that urban environmental exposures, such as air pollution, may play a role in the etiology of breast cancer. Combining modeled ambient air concentrations with data from a large prospective cohort of California women with over 15 years of follow-up, we examined the relationship between breast cancer incidence and modeled concentrations of air pollutants shown to be mammary gland carcinogens (MGCs).
  
  
  METHODS
  The study population of 112,378 California Teachers Study participants included 5,676 women diagnosed with invasive breast cancer. Modeled annual average ambient air concentrations of 24 MGCs from the U.S. Environmental Protection Agency were linked to participants' addresses. Cox proportional hazards models were used to estimate hazard rate ratios and 95% confidence intervals associated with residential MGC levels. MGCs were examined individually and as a combined summary variable for all participants, in selected subsets, and by tumor hormone responsiveness.
  
  
  RESULTS
  Initial models yielded some evidence for increased risk for several compounds, including acrylamide, carbon tetrachloride, chloroprene, 4,4'-methylene bis(2-chloroaniline), propylene oxide, and vinyl chloride, but after adjustment for multiple comparisons, only results for propylene oxide and vinyl chloride remained statistically significant. In subset analyses, estrogen-receptor positive or progesterone-receptor positive (ER+/PR+) tumors were associated with higher ambient levels of acrylamide, benzidine, carbon tetrachloride, ethylidene dichloride, and vinyl chloride, while ER-/PR- tumors were associated with higher ambient levels of benzene. Interesting results for different compounds were observed within certain subsets of the population.
  
  
  CONCLUSIONS
  While our initial models yielded several elevated risk estimates, after adjusting for multiple comparisons and breast cancer risk factors, most hazard ratios were no longer statistically significant. Our subset analyses, however, suggest that elevated risk may be associated with some compounds for certain subgroups of interest. A summary variable for all 24 MGCs did not offer any advantage over the models for individual compounds. Results must be interpreted cautiously, as estimated exposure was limited to modeled annual average ambient air concentrations, and could not account for other sources or routes other than inhalation.
authors: Cancer Prevention Institute of California, Berkeley, CA, 94704, USA.|School of Public Health, University of California, Berkeley, CA, 94720, USA.
authors: Erika
authors: E
authors: Garcia
authors: Cancer Prevention Institute of California, Berkeley, CA, 94704, USA.
authors: Susan
authors: S
authors: Hurley
authors: Cancer Prevention Institute of California, Berkeley, CA, 94704, USA.
authors: David O
authors: DO
authors: Nelson
authors: Cancer Prevention Institute of California, Berkeley, CA, 94704, USA.
authors: Andrew
authors: A
authors: Hertz
authors: Cancer Prevention Institute of California, Berkeley, CA, 94704, USA. peggy.reynolds@cpic.org.|Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, 94305, USA. peggy.reynolds@cpic.org.
authors: Peggy
authors: P
authors: Reynolds
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000633:toxicity*; D001943:Breast Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D002140:California / Q000453:epidemiology; D002273:Carcinogens / Q000633:toxicity*; D015331:Cohort Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D015994:Incidence; D042361:Mammary Glands, Human / Q000187:drug effects; D008875:Middle Aged; D008962:Models, Theoretical; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000393:Air Pollutants; D002273:Carcinogens
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