title: The centrosome and its duplication cycle.
abstract: The centrosome was discovered in the late 19th century when mitosis was first described. Long recognized as a key organelle of the spindle pole, its core component, the centriole, was realized more than 50 or so years later also to comprise the basal body of the cilium. Here, we chart the more recent acquisition of a molecular understanding of centrosome structure and function. The strategies for gaining such knowledge were quickly developed in the yeasts to decipher the structure and function of their distinctive spindle pole bodies. Only within the past decade have studies with model eukaryotes and cultured cells brought a similar degree of sophistication to our understanding of the centrosome duplication cycle and the multiple roles of this organelle and its component parts in cell division and signaling. Now as we begin to understand these functions in the context of development, the way is being opened up for studies of the roles of centrosomes in human disease.
authors: Cancer Research UK Cell Cycle Genetics Group, Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
authors: Jingyan
authors: J
authors: Fu
authors: Cancer Research UK Manchester Institute, University of Manchester, Withington, Manchester M20 4BX, United Kingdom.
authors: Iain M
authors: IM
authors: Hagan
authors: Cancer Research UK Cell Cycle Genetics Group, Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
authors: David M
authors: DM
authors: Glover
mesh_terms: D000818:Animals; D018385:Centrosome / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D002923:Cilia / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D004330:Drosophila / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D051379:Mice; D008938:Mitosis; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D016196:S Phase; D004718:Saccharomycetales / Q000378:metabolism / Q000648:ultrastructure; D008941:Spindle Apparatus / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D014982:Xenopus laevis
chemical_list: D029721:Drosophila Proteins; D017346:Protein Serine-Threonine Kinases; C522064:Sak protein, Drosophila
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