title: Non-genomic androgen action regulates proliferative/migratory signaling in stromal cells.
abstract: Prostate cancer (PCa) is the major cause of cancer-related death among the male population of Western society, and androgen-deprivation therapy (ADT) represents the first line in PCa treatment. However, although androgen receptor (AR) expression is maintained throughout the various stages of PCa, ADT frequently fails. Clinical studies have demonstrated that different androgen/AR signaling pathways operate in target tissues. AR stimulates growth and transformation of target cells, but under certain conditions slows down their proliferation. In this review, we discuss the role of AR in controlling different functions of mesenchymal and transformed mesenchymal cells. Findings here presented support the role of AR in suppressing proliferation and stimulating migration of stromal cells, with implications for current approaches to cancer therapy.
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Marzia
authors: M
authors: Di Donato
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Pia
authors: P
authors: Giovannelli
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Gustavo
authors: G
authors: Cernera
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Annalisa
authors: A
authors: Di Santi
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Irene
authors: I
authors: Marino
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Antonio
authors: A
authors: Bilancio
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Giovanni
authors: G
authors: Galasso
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Ferdinando
authors: F
authors: Auricchio
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Antimo
authors: A
authors: Migliaccio
authors: Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.
authors: Gabriella
authors: G
authors: Castoria
keywords: androgen receptor; fibroblasts; fibrosarcoma; filamin A; growth suppression; migration
references: Mol Cell Endocrinol. 2012 Apr 16;352(1-2):70-8
references: 21820033
references: Oncogene. 2014 Jun 19;33(25):3225-34
references: 23873027
references: Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6079-84
references: 23530240
references: J Exp Zool. 1978 Aug;205(2):181-93
references: 681909
references: Genes Cancer. 2010 Aug;1(8):859-67
references: 21779469
references: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12188-93
references: 18723670
references: J Cell Biol. 2003 May 12;161(3):547-56
references: 12743104
references: Cell Death Differ. 2014 Sep;21(9):1503
references: 24971480
references: Mol Med. 2011 Jan-Feb;17(1-2):48-58
references: 20957335
references: PLoS One. 2011 Feb 16;6(2):e17218
references: 21359179
references: J Cell Biol. 2003 Jun 23;161(6):1163-77
references: 12810700
references: Nature. 2013 Jul 11;499(7457):166-71
references: 23846654
references: Cell Cycle. 2007 Mar 15;6(6):647-51
references: 17387277
references: Int J Mol Sci. 2013 Jul 16;14 (7):14833-59
references: 23863692
references: Int J Cancer. 2006 May 1;118(9):2123-31
references: 16331600
references: Oncogene. 2010 Jun 24;29(25):3593-604
references: 20440270
references: Mol Endocrinol. 2012 Aug;26(8):1443-54
references: 22700587
references: Nat Struct Mol Biol. 2010 Jun;17 (6):718-25
references: 20512148
references: Cancer Res. 1989 Sep 1;49(17):4682-9
references: 2547513
references: PLoS One. 2013 Oct 09;8(10):e76899
references: 24130806
references: Nucleus. 2014 Sep-Oct;5(5):482-91
references: 25482200
references: In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):538-46
references: 20383666
references: Carcinogenesis. 2012 Jul;33(7):1391-8
references: 22535887
references: Am J Pathol. 2014 Oct;184(10):2598-607
references: 25088980
references: Med Oncol. 2013;30(3):674
references: 23925662
references: Cancer Res. 2001 Jan 15;61(2):423-7
references: 11212224
references: Cell Death Dis. 2014 Dec 04;5:e1548
references: 25476896
references: Phys Rev Lett. 2007 Mar 16;98(11):118101
references: 17501094
references: EMBO Mol Med. 2012 Aug;4(8):791-807
references: 22745041
references: Genes Dev. 2001 Apr 15;15(8):981-94
references: 11316792
references: Oncogene. 2012 Dec 13;31(50):5132-43
references: 22310282
references: J Cell Biol. 1994 Nov;127(3):847-57
references: 7962064
references: Cancer Res. 2007 Aug 1;67(15):7247-55
references: 17671193
references: Genes Cancer. 2014 Sep;5(9-10):337-47
references: 25352950
references: J Biol Chem. 2008 Jul 18;283(29):19948-56
references: 18499659
references: Mol Biol Cell. 2010 Jul 1;21(13):2338-54
references: 20462955
references: Cancer Res. 2008 Jun 1;68(11):4447-54
references: 18519708
references: Prostate. 2005 Apr 1;63(1):19-28
references: 15378523
references: J Cell Biol. 1994 Feb;124(4):547-55
references: 8106552