title: Two new aromadendrane sesquiterpenes from the stem bark of Alafia multiflora.
abstract: Two new aromadendrane sesquiterpenoids (1β,4β,5β,6α,7α,11S)-aromadendr-9-en-13,14-dioic acid (1) and (1β,4β,5β,6α,7α,11S)-13-oxoaromadendr-9-en-14-oic acid (2) have been isolated from the stem bark of Alafia multiflora along with β-sitosterol and β-sitosterol glucoside. Their structures were established on the basis of spectroscopic analyses, including 1D and 2D NMR experiments (1H-1H COSY, NOESY, HSQC, HMBC). Compound 1 showed a weak growth inhibitory activity against the murine melanoma line B16F10 MTT.
authors: Alembert T
authors: AT
authors: Tchinda
authors: David E
authors: DE
authors: Tsala
authors: Nnanga
authors: N
authors: Nga
authors: Ewa
authors: E
authors: Cieckiewicz
authors: Robert
authors: R
authors: Kiss
authors: Joseph D
authors: JD
authors: Connolly
authors: Michel
authors: M
authors: Frédérich
mesh_terms: D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane
chemical_list: D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C519959:aromadendrane