title: Added Value of pH Multichannel Intraluminal Impedance in Adults Operated for Esophageal Atresia.
abstract: BACKGROUND
  Gastroesophageal reflux (GER) and dysphagia are common following repaired esophageal atresia (EA). The risk of esophagitis and Barrett esophagus is increased compared with the general population. As yet, the causes are not fully explained.
  
  
  OBJECTIVE
  The aim of this study was to investigate how GER, measured by pH multichannel intraluminal impedance (pH-MII), is correlated to the esophageal symptoms and histological findings.
  
  
  METHODS
  Twenty-nine adult subjects operated for EA in Gothenburg from 1968 to 1983 were evaluated with pH-MII, manometry, and gastroscopy.
  
  
  RESULTS
  pH-MII was performed in 15, manometry in 19, and gastroscopy in 24 subjects. Eleven subjects displayed pathological reflux parameters of any kind, mainly nonacid reflux (10/15). Dysphagia correlated to the number of weakly acidic reflux episodes. Lower esophageal sphincter (LES) incompetence, which correlated to a pathological number of acid reflux episodes (p = 0.012), was noted in 21/24 subjects, but the majority had a normal resting pressure. Esophagitis was present in 14/24, two of whom had Barrett esophagus. Histological changes correlated to the reflux index and the number of weakly acidic reflux episodes (p = 0.028 and 0.040) and tended to correlate to dysphagia (p = 0.052).
  
  
  CONCLUSIONS
  pH-MII adds further information when it comes to explaining what causes symptoms and esophageal histological changes in adults operated for EA.
authors: Department of Pediatric Surgery, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
authors: Vladimir
authors: V
authors: Gatzinsky
authors: Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors: Olof
authors: O
authors: Andersson
authors: Division of Gastroenterology, Department of Internal Medicine and Geriatrics, SU/Östra, Gothenburg, Sweden.
authors: Anders
authors: A
authors: Eriksson
authors: Department of Pediatric Surgery, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
authors: Linus
authors: L
authors: Jönsson
authors: Department of Pediatric Surgery, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
authors: Kate
authors: K
authors: Abrahamsson
authors: Department of Pediatric Surgery, The Queen Silvia Children's Hospital, Gothenburg, Sweden.
authors: Ulla
authors: U
authors: Sillén
mesh_terms: D000328:Adult; D001823:Body Composition; D003680:Deglutition Disorders / Q000209:etiology; D003938:Diagnostic Techniques, Digestive System; D017097:Electric Impedance; D004933:Esophageal Atresia / Q000150:complications / Q000601:surgery*; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology; D050782:Esophageal pH Monitoring / Q000295:instrumentation / Q000379:methods*; D004941:Esophagitis / Q000209:etiology* / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008365:Manometry; D012189:Retrospective Studies; D011795:Surveys and Questionnaires