title: Design, synthesis and biological evaluation of novel bromophenol derivatives incorporating indolin-2-one moiety as potential anticancer agents.
abstract: A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g-4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure-activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs.
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. wanglijun@qdio.ac.cn.
authors: Li-Jun
authors: LJ
authors: Wang
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. 12-12sy@163.com.
authors: Shuai-Yu
authors: SY
authors: Wang
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. jiangbo@qdio.ac.cn.
authors: Bo
authors: B
authors: Jiang
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. wuning@qdio.ac.cn.
authors: Ning
authors: N
authors: Wu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. lnu101@163.com.
authors: Xiang-Qian
authors: XQ
authors: Li
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. 13365456626@163.com.
authors: Bao-Cheng
authors: BC
authors: Wang
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. luojiao2012@163.com.
authors: Jiao
authors: J
authors: Luo
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. qwyangmeng@163.com.
authors: Meng
authors: M
authors: Yang
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. shisheng14226@126.com.
authors: Shui-Hua
authors: SH
authors: Jin
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. shidayong@qdio.ac.cn.
authors: Da-Yong
authors: DY
authors: Shi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000517:prevention & control; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D010636:Phenols; C456900:indolin-2-one
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