title: Effect of rhBNP on renal function in STEMI-HF patients with mild renal insufficiency undergoing primary PCI.
abstract: This study aims to investigate the effect of recombinant human brain natriuretic peptide (rhBNP) on renal function and contrast-induced nephropathy (CIN) incidence in ST-segment elevation myocardial infarction and heart failure (STEMI-HF) patients with mild renal insufficiency undergoing primary percutaneous coronary intervention (PCI). A total of 116 participants were randomized into rhBNP (rhBNP, n = 57) and nitroglycerin group (NIT, n = 59), receiving intravenous rhBNP or nitroglycerin from admission to 72 h after PCI. Renal function was assessed by serum creatinine (SCr), estimated glomerular filtration rate (eGFR), Cystatin-C (Cys-C) and β2-microglobulin before and after primary PCI, and calculated the incidence of CIN within 72 h after PCI. There were no significant differences in SCr, eGFR and β2-microglobulin between the two groups (P > 0.05, respectively). Compared with the NIT group, the total urinary volume within 72 h was higher while the level of Cys-C at 24 and 72 h after PCI was lower in the rhBNP group. rhBNP was associated with a decline in the incidence of CIN (12.28 vs. 28.81 %, P < 0.05). No differences were detected in mortality and re-hospitalization in 3 months between the two groups. The incidence of renal injury was not different between rhBNP and nitroglycerin in STEMI-HF patients with mild renal insufficiency. However, infusion of rhBNP was associated with a decline in incidence of CIN.
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Kun
authors: K
authors: Xing
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. fuxh99@126.com.
authors: Xianghua
authors: X
authors: Fu
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Yanbo
authors: Y
authors: Wang
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Wei
authors: W
authors: Li
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Xinshun
authors: X
authors: Gu
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Guozhen
authors: G
authors: Hao
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Qing
authors: Q
authors: Miao
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Shiqiang
authors: S
authors: Li
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Yunfa
authors: Y
authors: Jiang
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Weize
authors: W
authors: Fan
authors: Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors: Wei
authors: W
authors: Geng
mesh_terms: D003404:Creatinine / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D045283:Natriuretic Agents / Q000008:administration & dosage; D020097:Natriuretic Peptide, Brain / Q000008:administration & dosage*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D011994:Recombinant Proteins; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D000072657:ST Elevation Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000628:therapy*
chemical_list: D045283:Natriuretic Agents; D011994:Recombinant Proteins; D020097:Natriuretic Peptide, Brain; D003404:Creatinine
keywords: Acute myocardial infarction; Cystatin-C; Mild renal insufficiency; Percutaneous coronary intervention; Serum creatinine; rhBNP
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