title: Effect of a single session of antimicrobial photodynamic therapy using indocyanine green in the treatment of chronic periodontitis: a randomized controlled pilot trial.
abstract: OBJECTIVE
  The aim of this randomized controlled pilot study was to evaluate the effects of indocyanine green (ICG) as an adjunct to nonsurgical periodontal therapy in terms of reduction in percentage of viable bacteria and host tissue injury.
  
  
  METHODS
  The study included a small cohort of 30 subjects diagnosed with chronic periodontitis. Three sites from three different quadrants were selected and were randomly treated by (1) scaling and root planing (SRP), (2) SRP with application of 810 nm diode laser, or (3) SRP with application of 810 nm diode laser and ICG at a concentration of 5 mg/ mL. Primary parameters included estimation of viable bacteria percentage and lactate dehydrogenase (LDH) levels. Secondary parameters included site-specific measures of plaque, gingivitis, pocket depth (PD), and clinical attachment loss (CAL) at specific time intervals.
  
  
  RESULTS
  Sites receiving laser and ICG resulted in a significant decrease in the percentage of viable bacteria at the end of 1 week when compared to the other groups. ICG application does not seem to cause tissue damage as evident by the LDH levels. Comparison of CAL and PD revealed nonsignificant differences in sites treated with laser and ICG at the end of the study period.
  
  
  CONCLUSIONS
  Laseractivated ICG dye may enhance the potential benefits of SRP and can be used as an adjunct to nonsurgical periodontal therapy.
authors: Kura
authors: K
authors: Srikanth
authors: Rampalli Viswa
authors: RV
authors: Chandra
authors: Aileni Amarender
authors: AA
authors: Reddy
authors: Bavigadda Harish
authors: BH
authors: Reddy
authors: Chakravarthy
authors: C
authors: Reddy
authors: Anumala
authors: A
authors: Naveen
mesh_terms: D000328:Adult; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D004396:Coloring Agents / Q000627:therapeutic use*; D003774:Dental Plaque Index; D012534:Dental Scaling; D004311:Double-Blind Method; D005260:Female; D005883:Gingival Crevicular Fluid / Q000382:microbiology; D006801:Humans; D007208:Indocyanine Green / Q000627:therapeutic use*; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010778:Photochemotherapy / Q000379:methods*; D010865:Pilot Projects; D016745:Root Planing; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green