title: Management of lipid disorders in patients living with HIV.
abstract: Since the discovery and development of antiretroviral therapy (ART), HIV has become a chronic disease with patients living longer lives and to ages where co-morbidities, such as cardiovascular disease (CVD) are prevalent. Diagnosis and management of risk factors for CVD, in particular dyslipidemia, have become an important part of the overall care for patients living with HIV infection. Existing guidelines and recommendations for the management of dyslipidemia for persons with HIV infection are largely based on guidelines for the general population. Clinical and epidemiologic research efforts are ongoing to provide information specific to patients living with HIV. This review offers a detailed guide for clinicians who manage dyslipidemia in patients infected with HIV. The first sections provide background information on dyslipidemia, risk stratification, and targets for lipid therapy. This is followed by a step-by-step approach for diagnosis and treatment with specific information on lipid drug use for patients with HIV. The recommendations presented here are based on existing guidelines for the general population, evidence from research in patients infected with HIV, and the clinical experience of the authors. Management issues for which little or no information is available specific to this patient population are noted and serve to highlight the many gaps in our knowledge that will need to be addressed.
authors: Mount Sinai Roosevelt and St. Luke's Hospital, Cardiovascular Disease Prevention Program and Lipid Clinic, Division of Cardiology, Infectious Diseases, and Institute for Advanced Medicine, New York, NY, USA.
authors: Merle
authors: M
authors: Myerson
authors: Family AIDS Clinic and Education Services, Nationwide Children's Hospital, Division of Infectious Diseases, Ohio State University Medical Center, Columbus, OH, USA.
authors: Carlos
authors: C
authors: Malvestutto
authors: Division of Infectious Diseases, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Judith A
authors: JA
authors: Aberg
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000150:complications* / Q000188:drug therapy; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents; D000960:Hypolipidemic Agents
keywords: HIV; antiretroviral therapy; cardiovascular risk factors; dyslipidemia