title: One-pot, three-component reaction using modified Julia reagents: a facile synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles in a wet organic solvent.
abstract: A new one-pot, three component reaction involving the use of Julia reagent, aldehyde, and sodium azide was developed for the efficient synthesis of N-unsubstituted 1,2,3-triazoles. This reaction could be carried out under mild reaction conditions without any precaution, and broad scope of substrates, both respect to Julia reagents and aldehydes, could be applied in this reaction system in generation of a small library of title compounds.
authors: School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, P. R. China.
authors: Huihui
authors: H
authors: Chai
authors: Ruiqiang
authors: R
authors: Guo
authors: Wei
authors: W
authors: Yin
authors: Lingping
authors: L
authors: Cheng
authors: Renhua
authors: R
authors: Liu
authors: Changhu
authors: C
authors: Chu
mesh_terms: D064751:Ammonium Compounds / Q000737:chemistry*; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry; D017155:Wettability
chemical_list: D064751:Ammonium Compounds; D012997:Solvents; D014230:Triazoles
keywords: 1,2,3,-triazoles; Julia reagent; multicomponent reaction; one pot; sodium azide