title: Genetics of hand grip strength in mid to late life.
abstract: Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55-85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.
authors: Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales (UNSW), NPI, Euroa Centre, Barker St, Randwick, Sydney, NSW, 2031, Australia.
authors: Jessica P L
authors: JP
authors: Chan
authors: Anbupalam
authors: A
authors: Thalamuthu
authors: Christopher
authors: C
authors: Oldmeadow
authors: Nicola J
authors: NJ
authors: Armstrong
authors: Elizabeth G
authors: EG
authors: Holliday
authors: Mark
authors: M
authors: McEvoy
authors: John B
authors: JB
authors: Kwok
authors: Amelia A
authors: AA
authors: Assareh
authors: Rosanne
authors: R
authors: Peel
authors: Stephen J
authors: SJ
authors: Hancock
authors: Simone
authors: S
authors: Reppermund
authors: Jasmine
authors: J
authors: Menant
authors: Julian N
authors: JN
authors: Trollor
authors: Henry
authors: H
authors: Brodaty
authors: Peter R
authors: PR
authors: Schofield
authors: John R
authors: JR
authors: Attia
authors: Perminder S
authors: PS
authors: Sachdev
authors: Rodney J
authors: RJ
authors: Scott
authors: Karen A
authors: KA
authors: Mather
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D015331:Cohort Studies; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
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