title: Dynamics of membrane tethers reveal novel aspects of cytoskeleton-membrane interactions in axons.
abstract: Mechanical properties of cell membranes are known to be significantly influenced by the underlying cortical cytoskeleton. The technique of pulling membrane tethers from cells is one of the most effective ways of studying the membrane mechanics and the membrane-cortex interaction. In this article, we show that axon membranes make an interesting system to explore as they exhibit both free membrane-like behavior where the tether-membrane junction is movable on the surface of the axons (unlike many other cell membranes) as well as cell-like behavior where there are transient and spontaneous eruptions in the tether force that vanish when F-actin is depolymerized. We analyze the passive and spontaneous responses of axonal membrane tethers and propose theoretical models to explain the observed behavior.
authors: Soft Condensed Matter group, Raman Research Institute, Bangalore, India.
authors: Anagha
authors: A
authors: Datar
authors: Institut Curie, Centre de Recherche. CNRS, UMR168 Physico-Chimie Curie and Université Pierre et Marie Curie, Paris, France.
authors: Thomas
authors: T
authors: Bornschlögl
authors: Institut Curie, Centre de Recherche. CNRS, UMR168 Physico-Chimie Curie and Université Pierre et Marie Curie, Paris, France.
authors: Patricia
authors: P
authors: Bassereau
authors: Institut Curie, Centre de Recherche. CNRS, UMR168 Physico-Chimie Curie and Université Pierre et Marie Curie, Paris, France; Mechanobiology Institute, National University of Singapore, Singapore.
authors: Jacques
authors: J
authors: Prost
authors: Soft Condensed Matter group, Raman Research Institute, Bangalore, India. Electronic address: pramod@rri.res.in.
authors: Pramod A
authors: PA
authors: Pullarkat
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000502:physiology*; D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000502:physiology*; D002645:Chickens; D003599:Cytoskeleton / Q000502:physiology*; D017276:Friction; D006367:HeLa Cells; D006801:Humans
chemical_list: D000199:Actins
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