title: [Role of PET-scan in the positive diagnosis of sarcoidosis in the work-up of uveitis].
abstract: BACKGROUND
  Sarcoidosis is a multisystem granulomatous inflammatory disease, which may present as uveitis. Work-up includes the search for pulmonary and extra-pulmonary sites, with the assistance of PET-scanning.
  
  
  METHODS
  We present six patients enrolled retrospectively from March 2012 to November 2013 with uveitis, for whom a systemic work-up was performed, along with specific tests for sarcoidosis. 18-FDG PET-scan was performed when histology was inconclusive for epithelioid granulomata and giant cells, or when CT and/or chest X-ray were normal, in cases of uveitis clinically suggestive of sarcoidosis.
  
  
  RESULTS
  Hypermetabolic foci were found in all patients, in inflammatory areas with foci mainly located in the mediastinal (65%), hilar (33%), cervical, and supraclavicular regions. There was no correlation between ACE levels and positivity of the PET-scan, since only two patients exhibited ACE > 70 IU/L.
  
  
  CONCLUSIONS
  PET-scan is a promising technique in the field of sarcoid uveitis; however, histologic proof remains the gold standard.
  
  
  CONCLUSIONS
  This study demonstrates the value of PET-scan in the assessment of indeterminate uveitis, by screening for sarcoidosis, and permits an assessment of the extent of the disease.
authors: CHU de Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France. Electronic address: Stephanie.le.reun@chu-rennes.fr.
authors: S
authors: S
authors: Le Reun
authors: CHU de Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France.
authors: M
authors: M
authors: Poulain
authors: CHU de Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France.
authors: A
authors: A
authors: Perlat
authors: CHU de Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France.
authors: B
authors: B
authors: Mortemousque
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging*; D014605:Uveitis / Q000000981:diagnostic imaging* / Q000209:etiology
keywords: ACE; Chest CT; ECA; Hypermetabolism; Hypermétabolisme; PET-scan; Sarcoidosis; Sarcoïdose; TDM thoracique; TEP-scan; Uveitis; Uvéite