title: The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles.
abstract: OBJECTIVE
  Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents.
  
  
  METHODS
  Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group.
  
  
  RESULTS
  We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group.
  
  
  CONCLUSIONS
  Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
authors: Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
authors: Sung Hwan
authors: SH
authors: Byun
authors: Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
authors: Eun Byul
authors: EB
authors: Kwon
authors: Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
authors: Se Young
authors: SY
authors: Kim
keywords: Adiponectin; CD40 ligand; Intercellular adhesion molecule-1; P-selectin
references: Am J Cardiol. 2002 Nov 21;90(10C):40L-48L
references: 12459427
references: Horm Metab Res. 2000 Feb;32(2):47-50
references: 10741683
references: Pediatrics. 1999 Jun;103(6 Pt 1):1175-82
references: 10353925
references: Atheroscler Suppl. 2005 May;6(2):7-14
references: 15823491
references: Endocr Rev. 2005 May;26(3):439-51
references: 15897298
references: Nat Rev Immunol. 2006 Oct;6(10):772-83
references: 16998510
references: Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1595-9
references: 10845877
references: J Clin Endocrinol Metab. 2004 Jan;89(1):87-90
references: 14715832
references: Int J Med Sci. 2008 Aug 29;5(5):248-62
references: 18773088
references: Circulation. 2002 Feb 5;105(5):546-9
references: 11827916
references: Clin Endocrinol (Oxf). 2005 May;62(5):567-72
references: 15853826
references: J Mol Cell Cardiol. 1999 Jan;31(1):23-37
references: 10072713
references: Metabolism. 1996 Feb;45(2):235-40
references: 8596496
references: Clin Chim Acta. 2007 May 1;380(1-2):24-30
references: 17343838
references: Indian Pediatr. 2010 Oct;47(10):829-39
references: 21048235
references: Circulation. 2002 Mar 5;105(9):1135-43
references: 11877368
references: N Engl J Med. 1999 Jan 14;340(2):115-26
references: 9887164
references: Nature. 2002 Dec 19-26;420(6917):868-74
references: 12490960
references: Int J Obes (Lond). 2008 Mar;32(3):429-35
references: 17895880
references: J Pediatr. 2009 Oct;155(4):529-34
references: 19555969
references: J Clin Endocrinol Metab. 2002 Oct;87(10):4652-6
references: 12364452
references: Obes Rev. 2005 Feb;6(1):13-21
references: 15655035
references: Eur J Endocrinol. 2003 Mar;148(3):293-300
references: 12611609