title: Color fundus photography versus fluorescein angiography in identification of the macular center and zone in retinopathy of prematurity.
abstract: OBJECTIVE
  To examine the usefulness of fluorescein angiography (FA) in identifying the macular center and diagnosis of zone in patients with retinopathy of prematurity (ROP).
  
  
  METHODS
  Validity and reliability analysis of diagnostic tools.
  
  
  METHODS
  Thirty-two sets (16 color fundus photographs and 16 color fundus photographs paired with the corresponding FA images) of wide-angle retinal images obtained from 16 eyes of 8 infants with ROP were compiled on a secure web site. Nine ROP experts (3 pediatric ophthalmologists and 6 vitreoretinal surgeons) participated in the study. For each image set, experts identified the macular center and provided a diagnosis of zone.
  
  
  METHODS
  (1) Sensitivity and specificity of zone diagnosis and (2) computer-facilitated diagnosis of zone, based on precise measurement of the macular center, optic disc center, and peripheral ROP.
  
  
  RESULTS
  Computer-facilitated diagnosis of zone agreed with the expert's diagnosis of zone in 28 (62%) of 45 cases using color fundus photographs and in 31 (69%) of 45 cases using FA images. Mean (95% confidence interval) sensitivity for detection of zone I by experts compared with a consensus reference standard diagnosis when interpreting the color fundus images alone versus interpreting the color fundus photographs and FA images was 47% (range, 35.3% to 59.3%) and 61.1% (range, 48.9% to 72.4%), respectively (t(9) ≥ (2.063); P = .073).
  
  
  CONCLUSIONS
  There is a marginally significant difference in zone diagnosis when using color fundus photographs compared with using color fundus photographs and the corresponding FA images. There is inconsistency between traditional zone diagnosis (based on ophthalmoscopic examination and image review) compared with a computer-facilitated diagnosis of zone.
authors: Department of Ophthalmology, Weill Cornell Medical College, New York, New York.
authors: Samir N
authors: SN
authors: Patel
authors: Department of Ophthalmology, Weill Cornell Medical College, New York, New York.
authors: Michael A
authors: MA
authors: Klufas
authors: Department of Ophthalmology, Casey Eye Institute at Oregon Health & Science University, Portland, Oregon.
authors: Michael C
authors: MC
authors: Ryan
authors: Department of Ophthalmology, Weill Cornell Medical College, New York, New York.
authors: Karyn E
authors: KE
authors: Jonas
authors: Department of Ophthalmology, Casey Eye Institute at Oregon Health & Science University, Portland, Oregon.
authors: Susan
authors: S
authors: Ostmo
authors: Asociación para Evitar la Ceguera en México, Mexico City, Mexico.
authors: Maria Ana
authors: MA
authors: Martinez-Castellanos
authors: Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida.
authors: Audina M
authors: AM
authors: Berrocal
authors: Department of Ophthalmology, Casey Eye Institute at Oregon Health & Science University, Portland, Oregon; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon.
authors: Michael F
authors: MF
authors: Chiang
authors: Department of Ophthalmology, Weill Cornell Medical College, New York, New York. Electronic address: roc9013@med.cornell.edu.
authors: R V Paul
authors: RV
authors: Chan
mesh_terms: D003936:Diagnosis, Computer-Assisted; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D010781:Photography / Q000379:methods*; D015203:Reproducibility of Results; D012178:Retinopathy of Prematurity / Q000175:diagnosis*; D012680:Sensitivity and Specificity
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