title: Chromosome folding: driver or passenger of epigenetic state?
abstract: Despite a growing understanding of how epigenetic marks such as histone modifications locally modify the activity of the chromatin with which they are associated, we know little about how marked regions on different parts of the genome are able to intercommunicate to effect regulation of gene expression programs. Recent advances in methods that systematically map pairwise chromatin interactions have uncovered important principles of chromosome folding, which are tightly linked to the epigenetic mark profiles and, hence, functional state of the underlying chromatin fiber.
authors: Institute of Human Genetics, Centre National de la Recherche Scientifique, 34396 Montpellier Cedex 5, France.
authors: Tom
authors: T
authors: Sexton
authors: Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Eitan
authors: E
authors: Yaffe
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D002875:Chromosomes / Q000737:chemistry / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D057890:Epigenomics; D005786:Gene Expression Regulation
references: Cold Spring Harb Perspect Biol. 2015 Oct 01;7(10):a019356
references: 26430217
references: Nature. 2012 Apr 11;485(7398):376-80
references: 22495300
references: Science. 2002 Feb 15;295(5558):1306-11
references: 11847345
references: Cell. 2012 Jun 8;149(6):1233-44
references: 22682246
references: Science. 2009 Oct 9;326(5950):289-93
references: 19815776
references: Cell. 2012 Feb 3;148(3):458-72
references: 22265598