title: The structure of clinical translation: efficiency, information, and ethics.
abstract: The so-called drug pipeline is not really about drugs and not much like a pipeline. It is really about the production and dissemination of information, and it is much more like a web. The misunderstanding leads to a poor understanding of what's wrong with clinical translation and how it can be improved.
authors: Jonathan
authors: J
authors: Kimmelman
authors: Alex John
authors: AJ
authors: London
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D026688:Bioethical Issues; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards / Q000639:trends; D017277:Drug Approval; D015507:Drugs, Investigational; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D033181:Information Dissemination / Q000941:ethics; D008962:Models, Theoretical; D056687:Off-Label Use; D011758:Pyrroles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D012107:Research Design; D000077210:Sunitinib; D057170:Translational Research, Biomedical / Q000941:ethics / Q000379:methods / Q000458:organization & administration / Q000592:standards / Q000639:trends
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib