title: The adverse influence of spina bifida occulta on the medical treatment outcome of primary monosymptomatic nocturnal enuresis.
abstract: OBJECTIVE
  Previous reports have suggested that the incidence of spina bifida occulta (SBO) in patients with primary monosymptomatic nocturnal enuresis (PMNE) is higher than the general population. The purpose of this study was to investigate the effect of spina bifida occulta on the medical treatment outcome of PMNE.
  
  
  METHODS
  Between January 2008 and December 2011, a total of 223 children (151 boys and 72 girls, aged 6-16 years; mean age: 10.1 ± 3.04 years) with PMNE were reviewed retrospectively. All of the children underwent physical examination, urine analysis, urinary tract ultrasonography and kidney ureter bladder (KUB) scout film. All patients were initially treated with a timed voiding program and were given desmopressin acetate when necessary.
  
  
  RESULTS
  Spina bifida occulta was detected in 75 children (33.6%). Spina bifida occulta affected L4 in 2 children, L5 in 6 children, L4-L5 in 3 children, S1 in 52 children, S2 in 7 children and S1-S2 in 2 children. Treatment was successful in 79% of the children without SBO, and in only 48% of the children with SBO. Medical treatment success rates differed significantly between the study groups.
  
  
  CONCLUSIONS
  The presence of spina bifida occulta significantly affects the response to medical treatment in patients with PMNE. Thus, verifying spina bifida occulta status in PMNE can facilitate prognostic predictions about the response to medical treatment.
authors: Hisar Intercontinental Hospital, Department of Urology, Umraniye, Istanbul. drbasri@gmail.com.
authors: Basri
authors: B
authors: Cakiroglu
authors: Tuncay
authors: T
authors: Tas
authors: Seyit Erkan
authors: SE
authors: Eyyupoglu
authors: Aydın Ismet
authors: AI
authors: Hazar
authors: Mustafa Bahadır
authors: MB
authors: Can Balcı
authors: Yunus
authors: Y
authors: Nas
authors: Fazli
authors: F
authors: Yilmazer
authors: Suleyman Hilmi
authors: SH
authors: Aksoy
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D016136:Spina Bifida Occulta / Q000150:complications; D016896:Treatment Outcome