title: Wybutosine biosynthesis: structural and mechanistic overview.
abstract: Over the last 10 years, significant progress has been made in understanding the genetics, enzymology and structural components of the wybutosine (yW) biosynthetic pathway. These studies have played a key role in expanding our understanding of yW biosynthesis and have revealed unexpected evolutionary ties, which are presently being unraveled. The enzymes catalyzing the 5 steps of this pathway, from genetically encoded guanosine to wybutosine base, provide an ensemble of amazing reaction mechanisms that are to be discussed in this review article.
authors: a University Grenoble Alpes ; Grenoble , France.
authors: Phanélie
authors: P
authors: Perche-Letuvée
authors: Thibaut
authors: T
authors: Molle
authors: Farhad
authors: F
authors: Forouhar
authors: Etienne
authors: E
authors: Mulliez
authors: Mohamed
authors: M
authors: Atta
mesh_terms: D001105:Archaea / Q000201:enzymology / Q000235:genetics; D019843:Archaeal Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000096:biosynthesis*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012436:S-Adenosylmethionine / Q000737:chemistry / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012359:tRNA Methyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D009705:Nucleosides; D029701:Saccharomyces cerevisiae Proteins; C467591:wybutosine; D012436:S-Adenosylmethionine; C541952:TYW4 protein, S cerevisiae; D012359:tRNA Methyltransferases
keywords: Fe-S clusters; Radical-SAM enzymes; S-adenosylmethionine; Wybutosine; tRNA modification
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