title: [De novo malignant tumors following liver transplantation. A single-center experience in Argentina].
abstract: The aim of the present study was to evaluate the incidence and clinical features of de novo tumors in patients undergoing liver transplantation in our center as well as to assess survival. We retrospectively analyzed 168 liver transplantations (159 patients) performed from May 2006 to May 2014. The incidence of de novo tumors was 7.5% (n = 12). The mean age at diagnosis was 63 ± 7 years. The most frequent neoplasms were non melanoma skin tumors and adenocarcinomas. Fifty percent of the tumors developed in the second and third year after transplantation. Type of immunosuppression did not influence tumoral type, although most patients receive tacrolimus in combination with mycofenolate and/or corticoids. The mean duration of follow-up after diagnosis of the tumor was 25 ± 29 months (range 0-76) and the mortality was 41%. The actuarial probability of survival at 1 and 5 years was 83 and 55%, respectively. De novo tumors are frequent after liver transplantation and their clinical course differs from that in the general population. Because their clinical course is more aggressive, regular follow up of these patients is essential for early diagnosis.
authors: Programa Trasplante Hepático, Unidad de Trasplante, Hospital Alemán, Buenos Aires, Argentina.
authors: Florencia
authors: F
authors: Antinucci
authors: Margarita
authors: M
authors: Anders
authors: Federico
authors: F
authors: Orozco
authors: José
authors: J
authors: Mella
authors: Manuel
authors: M
authors: Cobos
authors: Lucas
authors: L
authors: McCormack
authors: Ricardo
authors: R
authors: Mastai
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000453:epidemiology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016019:Survival Analysis
chemical_list: D004338:Drug Combinations; D007166:Immunosuppressive Agents
keywords: de novo tumors; liver transplantation; neoplasm