title: Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study.
abstract: OBJECTIVE
  Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidaemia, elevated blood pressure and insulin resistance, is a major public health concern in the United States. The effects of apolipoprotein E (Apo E) polymorphism on MetS are not well established.
  
  
  METHODS
  We conducted a cross-sectional study consisting of 1551 participants from the National Heart, Lung and Blood Institute Family Heart Study to assess the relation of Apo E polymorphism with the prevalence of MetS. MetS was defined according to the American Heart Association-National Heart, Lung and Blood Institute-International Diabetes Federation-World Health Organization harmonized criteria. We used generalized estimating equations to estimate adjusted odds ratios (ORs) for prevalent MetS and the Bonferroni correction to account for multiple testing in the secondary analysis.
  
  
  RESULTS
  Our study population had a mean age (standard deviation) of 56.5 (11.0) years, and 49.7% had MetS. There was no association between the Apo E genotypes and the MetS. The multivariable adjusted ORs (95% confidence interval) were 1.00 (reference), 1.26 (0.31-5.21), 0.89 (0.62-1.29), 1.13 (0.61-2.10), 1.13 (0.88-1.47) and 1.87 (0.91-3.85) for the Ɛ3/Ɛ3, Ɛ2/Ɛ2, Ɛ2/Ɛ3, Ɛ2/Ɛ4, Ɛ3/Ɛ4 and Ɛ4/Ɛ4 genotypes, respectively. In a secondary analysis, Ɛ2/Ɛ3 genotype was associated with 41% lower prevalence odds of low high-density lipoprotein [multivariable adjusted ORs (95% confidence interval) = 0.59 (0.36-0.95)] compared with Ɛ3/Ɛ3 genotype.
  
  
  CONCLUSIONS
  Our findings do not support an association between Apo E polymorphism and MetS in a multicentre population-based study of predominantly White US men and women.
authors: School of Medicine, Boston University, 72, East Concord St, Boston, MA, USA.|Clinical Research Center, Sarawak General Hospital, Kuching, Malaysia.
authors: Lana Y H
authors: LY
authors: Lai
authors: Division of Aging, Brigham and Women's Hospital, Boston, MA, USA.
authors: Andrew B
authors: AB
authors: Petrone
authors: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
authors: James S
authors: JS
authors: Pankow
authors: Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors: Donna K
authors: DK
authors: Arnett
authors: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
authors: Kari E
authors: KE
authors: North
authors: Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA.
authors: R Curtis
authors: RC
authors: Ellison
authors: Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA.
authors: Steven C
authors: SC
authors: Hunt
authors: School of Medicine, Boston University, 72, East Concord St, Boston, MA, USA.|Department of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston, MA, USA.
authors: James L
authors: JL
authors: Rosenzweig
authors: Division of Aging, Brigham and Women's Hospital, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.|Boston Veterans Affairs Healthcare System, Boston, MA, USA.
authors: Luc
authors: L
authors: Djoussé
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D054555:National Heart, Lung, and Blood Institute (U.S.); D011110:Polymorphism, Genetic; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D001057:Apolipoproteins E
keywords: apolipoprotein E (Apo E) polymorphism; blood pressure; dyslipidaemia; glucose; high-density lipoprotein cholesterol; metabolic syndrome
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