title: Follow-up monoclonal gammopathy of undetermined significance in kidney transplant.
abstract: OBJECTIVE
  The aim of this work was to review the incidence of monoclonal gammopathy of undetermined significance (MGUS) and complications in kidney transplant (KT) patients at the Puerta del Mar Hospital in Cádiz, Spain. This diagnosis was not considered to be a contraindication for transplantation.
  
  
  METHODS
  To estimate the incidence of MGUS in KT patients we used the database of our hospital, which included 1,016 patients who received a KT from 1992 to 2012 with a median follow-up of 30 months. The incidence of MGUS in non-transplant patients was estimated from the literature.
  
  
  RESULTS
  Out of 1,016 KT patients, 16 developed MGUS; 10 (72.5%) were >50 years old. Two patients developed post-transplantation lymphoproliferative disorders. No cases of progression to multiple myeloma or amyloidosis were seen during immune suppression therapy or after.
  
  
  CONCLUSIONS
  MGUS was >100 times more frequent in KT recipients than in the general population (P < .05). But in contrast to MGUS in general population, progression to plasma cell dyscrasia in these patients was absent and its incidence is unknown in KT patients.
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain. Electronic address: cuellarcarolina@yahoo.com.
authors: C
authors: C
authors: Cuéllar-García
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: C
authors: C
authors: Sevillano Ruiz-Mateos
authors: Nephrology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: M A
authors: MA
authors: Mazuecos Blanca
authors: Nephrology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: C
authors: C
authors: Narvaez Mejia
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: M C
authors: MC
authors: Fernandez Valle
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: V
authors: V
authors: Martin Reina
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: M
authors: M
authors: Gonzalez Bernal
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: M
authors: M
authors: Yera Cobo
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: R
authors: R
authors: Rodriguez Lopez
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: C
authors: C
authors: de Cos Hohr
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: M P
authors: MP
authors: Garrastazul
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: I
authors: I
authors: Marchante
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: A
authors: A
authors: Paz Coll
authors: Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: F J
authors: FJ
authors: Capote Huelva
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000453:epidemiology / Q000209:etiology*; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D013030:Spain