title: Variation in incidence and survival by ethnicity for patients with myeloma in England (2002-2008).
abstract: Incidence and relative survival of myeloma by ethnic group was estimated using data from cancer registries in England (2002-2008). Multiple imputation was used to address missing ethnicity data. In total 24 361 cases of myeloma were identified. Age-standardized incidence rate (ASIR) (per 100 000) was higher in the Black ethnic category at 15.00 (95% confidence interval [CI] 13.50-16.40), than amongst South Asians (ASIR = 5.45, 95% CI 4.76-6.14) or the White group (ASIR = 6.11, 95% CI 6.00-6.22). There was a lower risk of death in the Black group for both 1- and 3-year survival (hazard ratio [HR]1 year = 0.66, 95% CI 0.55-0.79; HR3 year = 0.69, 95% CI 0.58-0.83) and South Asians at 1, 3 and 5 years (HR1 year = 0.65, 95% CI 0.51-0.82; HR3 year = 0.72, 95% CI I 0.57-0.90; HR5 year = 0.68, 95% CI 0.50-0.92) when compared to the White population. Further study of differences in myeloma and precursor biology between population groups is important.
authors: a Public Health England Knowledge and Information Team (Northern and Yorkshire), Innovation Centre, University of York , York , UK.
authors: E Faye
authors: EF
authors: Samy
authors: b Haematological Malignancy Clinical Reference Group, National Cancer Intelligence Network , London , UK.
authors: James
authors: J
authors: Ross
authors: c Cancer Informatics Team, Leeds Teaching Hospitals , Leeds , UK.
authors: Edward
authors: E
authors: Bolton
authors: d Cancer Epidemiology Group, Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital , Leeds , UK.
authors: Eva J
authors: EJ
authors: Morris
authors: e Department of Health Sciences and the Hull York Medical School , University of York , York , UK.
authors: Steven E
authors: SE
authors: Oliver
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D004739:England / Q000453:epidemiology / Q000208:ethnology; D005006:Ethnicity; D005260:Female; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology* / Q000266:history / Q000401:mortality; D011159:Population Surveillance; D012042:Registries; D012307:Risk Factors; D016019:Survival Analysis; D055815:Young Adult
keywords: Multiple myeloma; ethnicity; incidence; multiple imputation; outcome