title: Histologic validation of vacuum sealed, formalin-free tissue preservation, and transport system.
abstract: We describe five validation trials of new vacuum sealing technologies that change the approach to the preanalytic "front end" of specimen transport, handling, and processing and illustrate their adaptation and integration into existing Lean laboratory operations with reduction in formalin use and personnel exposure to this toxic and potentially carcinogenic fixative. These trials provide histologic assessment by numerous pathologists of tissues processed in this new paradigm and define the financial advantages of applying this technology to the postanalytic or "back end" process of tissue storage. We conclude that the TisssueSAFE and SealSAFE vacuum sealing systems are both promising technologies for preserving fresh human specimens that can promote a safer environment by markedly reducing formalin use in operating room theaters and can minimize formalin use by laboratories.
authors: Pathology and Laboratory Medicine, Henry Ford Health System, 2799 West Grand Blvd, Detroit, MI, 48202, USA, rzarbo1@hfhs.org.
authors: Richard J
authors: RJ
authors: Zarbo
mesh_terms: D005557:Formaldehyde; D006652:Histological Techniques; D006801:Humans; D013048:Specimen Handling / Q000295:instrumentation / Q000379:methods / Q000592:standards; D013696:Temperature; D013997:Time Factors; D014021:Tissue Preservation / Q000295:instrumentation / Q000379:methods / Q000592:standards; D020858:Tissue and Organ Harvesting / Q000379:methods / Q000592:standards; D014186:Transportation / Q000379:methods; D014618:Vacuum
chemical_list: D005557:Formaldehyde