title: Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil.
abstract: Evidence-based strategies to improve the hepatitis B virus (HBV) vaccination coverage rates might help to reduce the burden caused by co-infection with HBV and human immunodeficiency virus (HIV). In this study, the aim was to evaluate the vaccination coverage and immunity against HBV among HIV-infected individuals in South Brazil, and identify factors that are associated with compliance patterns and antibody reactivity. Three hundred HIV-infected men and women were included in this survey. The patients answered a standardized questionnaire, and vaccination cards were checked in order to assess hepatitis B vaccine status. A blood sample was collected for quantitative determination of antibody to hepatitis B virus surface antigen (anti-HBs). Participants were also evaluated for their CD4 cell count and HIV viral load. The overall vaccination coverage of HBV vaccination found in this study (57.4%) was lower than that was previously reported in South Brazil. Anti-HBs levels >10IU/L were observed in 47.0% of the studied population. A significant inequality in the coverage rates and antibody reactivity was found in favor of patients with better economic status. In conclusion, the results indicate the need for improvement in the HBV vaccination coverage among HIV carriers, in particular focusing on low-income individuals.
authors: Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil; Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Saulo
authors: S
authors: Martins
authors: Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Andréa do
authors: Ad
authors: Livramento
authors: Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Michelle
authors: M
authors: Andrigueti
authors: Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Iara Fabricia
authors: IF
authors: Kretzer
authors: Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Marcos José
authors: MJ
authors: Machado
authors: Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil.
authors: Celso
authors: C
authors: Spada
authors: Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, University Campus, Florianópolis, SC, Brazil. Electronic address: aricio.treitinger@ufsc.br.
authors: Arício
authors: A
authors: Treitinger
mesh_terms: D000328:Adult; D001938:Brazil; D018791:CD4 Lymphocyte Count; D002353:Carrier State; D060085:Coinfection; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: HBV; HIV; Hepatitis B; Immunity; Vaccination
references: Rev Soc Bras Med Trop. 2011 Jul-Aug;44(4):412-5
references: 21789351
references: Vaccine. 2009 Jul 23;27(34):4731-8
references: 19540026
references: AIDS. 2000 Jan 7;14(1):11-21
references: 10714563
references: Vaccine. 2012 May 21;30(24):3703-9
references: 22446635
references: Rev Soc Bras Med Trop. 2011 Jul-Aug;44(4):416-9
references: 21860885
references: JAMA. 2011 Apr 13;305(14):1432-40
references: 21486976
references: Vaccine. 2006 Nov 30;24(49-50):7124-8
references: 16884833
references: PLoS One. 2012;7(11):e49314
references: 23145150
references: Clin Infect Dis. 2004 May 15;38(10):1478-84
references: 15156488
references: J Infect Dis. 2011 Apr 1;203(7):984-91
references: 21266513
references: Vaccine. 2011 Nov 15;29(49):9284-8
references: 21722687
references: Vaccine. 2000 Jan 18;18(13):1161-5
references: 10649616
references: Lancet Infect Dis. 2007 Jun;7(6):402-9
references: 17521593
references: Hepatology. 1999 Apr;29(4):1306-10
references: 10094979
references: J Hepatol. 2006;44(1 Suppl):S6-9
references: 16352363
references: Lancet. 2002 Dec 14;360(9349):1921-6
references: 12493258
references: Vaccine. 2005 Apr 22;23(22):2902-8
references: 15780739
references: J Formos Med Assoc. 2008 May;107(5):404-11
references: 18492625
references: Braz J Infect Dis. 2010 Jan-Feb;14(1):60-5
references: 20428656
references: Vaccine. 2012 Sep 7;30(41):5973-7
references: 22828589
references: Cad Saude Publica. 2002;18 Suppl:77-87
references: 12563503
references: Clin Infect Dis. 2005 Oct 1;41(7):1045-8
references: 16142673
references: Cad Saude Publica. 2011 Apr;27(4):753-8
references: 21603758
references: J Hepatol. 1997 Jul;27(1):18-24
references: 9252068
references: Bull World Health Organ. 1991;69(5):623-30
references: 1959164
references: Vaccine. 2010 Jan 8;28(3):730-6
references: 19892043
references: J Infect Dis. 2008 Jan 15;197(2):292-4
references: 18177248
references: Scand J Infect Dis. 2008;40(1):54-8
references: 17852939