title: FutureTox II: in vitro data and in silico models for predictive toxicology.
abstract: FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology.
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Thomas B
authors: TB
authors: Knudsen
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy douglas.keller@sanofi.com.
authors: Douglas A
authors: DA
authors: Keller
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Miriam
authors: M
authors: Sander
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Edward W
authors: EW
authors: Carney
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Nancy G
authors: NG
authors: Doerrer
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: David L
authors: DL
authors: Eaton
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Suzanne Compton
authors: SC
authors: Fitzpatrick
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Kenneth L
authors: KL
authors: Hastings
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Donna L
authors: DL
authors: Mendrick
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Raymond R
authors: RR
authors: Tice
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Paul B
authors: PB
authors: Watkins
authors: United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.
authors: Maurice
authors: M
authors: Whelan
mesh_terms: D003198:Computer Simulation; D003226:Congresses as Topic; D066298:In Vitro Techniques; D011237:Predictive Value of Tests; D012958:Societies, Scientific; D014116:Toxicology / Q000379:methods* / Q000639:trends*; D014481:United States
keywords: in silico; in vitro; modeling; predictive toxicology; risk assessment
references: Arch Intern Med. 2007 Sep 10;167(16):1752-9
references: 17846394
references: Nat Rev Cancer. 2007 Jan;7(1):54-60
references: 17186018
references: N Engl J Med. 2010 Oct 7;363(15):1397-409
references: 20660394
references: Environ Toxicol Chem. 2010 Mar;29(3):730-41
references: 20821501
references: Toxicol Sci. 2010 Mar;114(1):20-4
references: 20026472
references: Chem Res Toxicol. 2011 Aug 15;24(8):1251-62
references: 21699217
references: Science. 2013 Aug 9;341(6146):651-4
references: 23868920
references: Stem Cell Res Ther. 2013;4 Suppl 1:I1
references: 24565163
references: Toxicol Sci. 2009 Aug;110(2):251-4
references: 19468057
references: Nat Rev Drug Discov. 2013 Aug;12(8):565-7
references: 23903208
references: Environ Health Perspect. 2013 Jul;121(7):756-65
references: 23603828
references: Toxicology. 2013 Oct 4;312:158-65
references: 23978457
references: J Appl Toxicol. 2014 Jan;34(1):1-18
references: 24166207
references: Trends Biotechnol. 2012 Aug;30(8):421-5
references: 22652049
references: Toxicol Sci. 2012 Apr;126(2):291-7
references: 22262567
references: J Mol Cell Cardiol. 2012 May;52(5):998-1008
references: 22353256
references: Nat Biotechnol. 2014 Jun;32(6):583-91
references: 24837663
references: Toxicol Sci. 2013 Jul;134(1):180-94
references: 23596260
references: Toxicol Sci. 2009 Nov;112(1):17-22
references: 19703945
references: J Chem Inf Model. 2014 Jan 27;54(1):1-4
references: 24251851
references: Genome Biol. 2006;7(7):R61
references: 16859521
references: Toxicol Sci. 2009 Jul;110(1):40-6
references: 19435982
references: Methods Cell Biol. 2012;110:325-66
references: 22482955
references: Toxicol Appl Pharmacol. 2013 Sep 15;271(3):309-23
references: 20353796
references: Environ Health Perspect. 2009 Apr;117(4):624-31
references: 19440503
references: J Pharmacol Exp Ther. 2012 May;341(2):510-7
references: 22353878
references: Environ Health Perspect. 2013 Jan;121(1):23-31
references: 23086705
references: Chem Res Toxicol. 2014 Mar 17;27(3):314-29
references: 24446777
references: Toxicol Sci. 2009 Dec;112(2):297-302
references: 19805406
references: Toxicol Sci. 2009 Mar;108(1):19-21
references: 19168570
references: Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63
references: 23485712
references: Toxicol Sci. 2011 Sep;123(1):281-9
references: 21693436
references: Environ Health Perspect. 2015 Mar;123(3):237-45
references: 25376053
references: Science. 2008 Feb 15;319(5865):906-7
references: 18276874
references: BMC Syst Biol. 2011 Nov 11;5:190
references: 22074594
references: Toxicol Sci. 2012 Jan;125(1):157-74
references: 21948869
references: Methods Mol Biol. 2013;969:3-28
references: 23296924
references: Chem Res Toxicol. 2013 Dec 16;26(12):1840-61
references: 24206190
references: Toxicol Sci. 2011 Oct;123(2):349-58
references: 21750347
references: Environ Toxicol Chem. 2011 Jan;30(1):64-76
references: 20963853
references: Toxicol Sci. 2014 Feb;137(2):269-77
references: 24204016
references: Toxicol Sci. 2010 Sep;117(1):17-24
references: 20573784
references: Environ Health Perspect. 2013 Jan;121(1):7-14
references: 23052129
references: Chem Res Toxicol. 2012 Jul 16;25(7):1287-302
references: 22519603
references: Genetics. 2012 Feb;190(2):389-401
references: 22345608
references: Toxicol Sci. 2013 Apr;132(2):327-46
references: 23358191
references: Birth Defects Res C Embryo Today. 2011 Dec;93(4):312-23
references: 22271680
references: Environ Toxicol Chem. 2011 Jan;30(1):9-21
references: 20963854