title: Comparison of salivary epidermal growth factor levels in patients with gingivitis and advanced periodontitis and healthy subjects.
abstract: OBJECTIVE
  Epidermal growth factor (EGF) is a polypeptide molecule, with important functions in epithelial growth and wound repair. It exerts its effects on cells by binding to receptors on the cell surface. The aim of this study was to evaluate and compare salivary EGF levels in patients with gingivitis and advanced periodontitis as well as in healthy controls.
  
  
  METHODS
  Unstimulated salivary samples were collected from patients with gingivitis and advanced periodontitis and healthy individuals. The clinical parameters of plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) were measured and recorded using a Williams probe. The enzyme-linked immunosorbent assay (ELISA) was used to determine salivary levels of EGF. One-way ANOVA was used for data analysis.
  
  
  RESULTS
  The mean salivary level of EGF in healthy individuals (99.27) was significantly higher than that in patients with gingivitis (61.53). This value in patients with gingivitis (61.53) was also significantly higher than that in subjects with periodontitis (36.14) (P<0.001).
  
  
  CONCLUSIONS
  The reduction in salivary level of EGF in patients with periodontal disease may be related to the pathogenesis of periodontitis.
authors: Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mahvash
authors: M
authors: Moosavijazi
authors: Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors: Amir Alireza
authors: AA
authors: Rasouli Ghahroudi
authors: Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors: Siamak
authors: S
authors: Yaghoobee
authors: Postgraduate Student, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mojtaba
authors: M
authors: Bayani
authors: Assistant Professor, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Eisa
authors: E
authors: Salehi
authors: Prosthodontist, Private Practice, Tehran, Iran.
authors: Roozbeh
authors: R
authors: Sadrimanesh
keywords: Epidermal Growth Factor; Gingivitis; Periodontitis; Salivary Glands; Salivary Proteins and Peptides
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