title: Bioactive prenylated xanthones from the young fruits and flowers of Garcinia cowa.
abstract: Five new xanthones, garciniacowones A-E (1-5), together with 14 known xanthones, 6-19, were isolated from the young fruits and fresh flowers of Garcinia cowa. The structures of 1-5 were elucidated by analysis of their 1D and 2D NMR spectra and mass spectrometric data. The compounds 1-19 were tested in vitro for their antimicrobial activity and for their ability to inhibit α-glucosidase. Compounds 16 and 17 showed the most potent α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 and 8.7 ± 0.3 μM, respectively. Compounds 8, 9, and 19 showed antibacterial activity against Bacillus subtilis TISTR 088 with identical MIC values of 2 μg/mL, while 8, 10, and 19 exhibited antibacterial activity against Bacillus cereus TISTR 688 with identical MIC values of 4 μg/mL.
authors: Natural Products Research Laboratory, School of Science, Mae Fah Luang University , Tasud, Muang, Chiang Rai 57100, Thailand.
authors: Teerayut
authors: T
authors: Sriyatep
authors: Ittipon
authors: I
authors: Siridechakorn
authors: Wisanu
authors: W
authors: Maneerat
authors: Acharavadee
authors: A
authors: Pansanit
authors: Thunwadee
authors: T
authors: Ritthiwigrom
authors: Raymond J
authors: RJ
authors: Andersen
authors: Surat
authors: S
authors: Laphookhieo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D029760:Garcinia / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054876:Prenylation; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D065089:Glycoside Hydrolase Inhibitors; D044004:Xanthones; D000520:alpha-Glucosidases