title: Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria.
abstract: As mitochondria have an important role as ATP supplier, cellular ROS producer and apoptosis regulator, these organelles are a promising target for pharmacological intervention in the treatment and management of several diseases. Consequently, research on mitochondria-targeted drugs, which exclude other intracellular structures or extracellular processes, is becoming a hot topic. One approach to address the specific targeting is to conjugate bioactive molecules to a lipophilic cation such as the triphenylphosphonium (TPP(+)). In this chapter, the development of a new antioxidant based on the dietary cinnamic acid-caffeic acid-is described as well as the demonstration of its mitochondriotropic activity.
authors: CIQ/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, 4169-007, Portugal.
authors: José
authors: J
authors: Teixeira
authors: Pedro
authors: P
authors: Soares
authors: Sofia
authors: S
authors: Benfeito
authors: Michael P
authors: MP
authors: Murphy
authors: Paulo J
authors: PJ
authors: Oliveira
authors: Fernanda
authors: F
authors: Borges
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D002109:Caffeic Acids / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D002458:Cell Fractionation / Q000379:methods; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; C040048:caffeic acid