title: Th17 cells in autoimmune diseases.
abstract: Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, inflammatory bowel disease, and multiple sclerosis.
authors: Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Lei
authors: L
authors: Han
authors: Jing
authors: J
authors: Yang
authors: Xiuwen
authors: X
authors: Wang
authors: Dan
authors: D
authors: Li
authors: Ling
authors: L
authors: Lv
authors: Bin
authors: B
authors: Li
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D058990:Molecular Targeted Therapy; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines
references: Arthritis Res Ther. 2010;12(6):R220
references: 21182786
references: Arthritis Res Ther. 2005;7(1):29-37
references: 15642151
references: Arthritis Rheum. 2009 May;60(5):1472-83
references: 19404966
references: Sci Signal. 2009 Oct 13;2(92 ):ra63
references: 19825828
references: J Exp Med. 2003 Dec 15;198(12):1951-7
references: 14662908
references: Nature. 2011 Apr 28;472(7344):491-4
references: 21499262
references: J Immunol. 2014 May 1;192(9):4134-44
references: 24683191
references: Ann Lab Med. 2013 Jan;33(1):52-9
references: 23301223
references: J Immunol. 2008 Aug 15;181(4):2898-906
references: 18684981
references: N Engl J Med. 2002 Aug 8;347(6):417-29
references: 12167685
references: Arthritis Rheum. 2008 Mar;58(3):734-43
references: 18311793
references: J Autoimmun. 2011 Feb;36(1):65-75
references: 21075597
references: Gut. 2012 Dec;61(12):1693-700
references: 22595313
references: J Biol Chem. 2011 Jul 1;286(26):22707-10
references: 21566134
references: Mol Biol Rep. 2010 Jan;37(1):81-5
references: 19347604
references: Nat Immunol. 2012 Nov;13(11):1110-7
references: 23042150
references: Nature. 2008 May 1;453(7191):65-71
references: 18362915
references: Nat Immunol. 2008 Jun;9(6):641-9
references: 18454151
references: Cell. 2006 Sep 22;126(6):1121-33
references: 16990136
references: Immunity. 2013 Jan 24;38(1):53-65
references: 23159439
references: Lupus. 2012 Nov;21(13):1385-96
references: 22892208
references: Nature. 2006 May 11;441(7090):235-8
references: 16648838
references: Eur J Immunol. 2012 Sep;42(9):2232-7
references: 22949321
references: J Exp Med. 2006 Nov 27;203(12):2673-82
references: 17088434
references: J Neuroimmunol. 2014 Aug 15;273(1-2):31-41
references: 24975323
references: Nat Immunol. 2007 Sep;8(9):942-9
references: 17676045
references: J Biol Chem. 2007 Mar 30;282(13):9358-63
references: 17277312
references: Inflammation. 2015 Feb;38(1):180-6
references: 25240765
references: Arthritis Rheum. 2011 Jan;63(1):73-83
references: 20954258
references: Nat Rev Immunol. 2001 Nov;1(2):147-53
references: 11905822
references: Nat Med. 2014 Jan;20(1):62-8
references: 24362934
references: Nat Immunol. 2008 Jun;9(6):650-7
references: 18454150
references: Mucosal Immunol. 2013 Nov;6(6):1143-56
references: 23462910
references: Ann Rheum Dis. 2013 Oct;72(10):1700-7
references: 23328939
references: Clin Rheumatol. 2014 Apr;33(4):523-9
references: 24420723
references: Clin Immunol. 2008 Jun;127(3):385-93
references: 18373953
references: Ann Rheum Dis. 2009 Apr;68(4):604-6
references: 19286907
references: J Clin Immunol. 2013 May;33(4):767-74
references: 23435610
references: Eur J Immunol. 2014 Feb;44(2):339-47
references: 24310226
references: Inflamm Bowel Dis. 2010 Oct;16(10):1808-13
references: 20222127
references: Nat Immunol. 2012 Oct;13(10):991-9
references: 22961052
references: Nat Immunol. 2007 Sep;8(9):958-66
references: 17676043
references: Immunity. 2014 Apr 17;40(4):477-89
references: 24745332
references: J Immunol. 2007 Dec 15;179(12):8098-104
references: 18056351
references: Clin Dev Immunol. 2013;2013:986789
references: 24454481
references: Autoimmunity. 1993;15(2):137-43
references: 7692995
references: Rheumatol Int. 2012 Apr;32(4):949-58
references: 21243492
references: PLoS One. 2013;8(3):e57820
references: 23469245
references: Ann Rheum Dis. 2013 Feb;72(2):286-92
references: 22904262
references: J Immunol. 2014 Jul 15;193(2):540-3
references: 24920843
references: PLoS One. 2012;7(4):e31000
references: 22485125
references: Nat Rev Rheumatol. 2010 Sep;6(9):529-37
references: 20683439
references: Clin Immunol. 2011 Nov;141(2):197-204
references: 21920821
references: J Exp Med. 2008 May 12;205(5):1063-75
references: 18411338
references: Autoimmun Rev. 2014 Jan;13(1):3-10
references: 23774107
references: Immunol Lett. 2011 Dec 30;141(1):1-9
references: 21777618
references: Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii116-23
references: 23253932
references: J Exp Med. 2007 Jan 22;204(1):41-7
references: 17227914
references: Gastroenterology. 2008 Oct;135(4):1130-41
references: 18706417
references: Nature. 2011 Apr 28;472(7344):486-90
references: 21441909
references: Diagn Immunol. 1983;1(3):233-9
references: 6238753
references: Eur J Immunol. 2008 Jul;38(7):1833-8
references: 18546146
references: Am J Pathol. 2012 Jul;181(1):8-18
references: 22640807
references: J Clin Invest. 2009 Jan;119(1):61-9
references: 19075395
references: J Immunol. 2008 Dec 15;181(12):8761-6
references: 19050297
references: Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14751-6
references: 20679229
references: Sci Transl Med. 2010 Oct 6;2(52):52ra72
references: 20926833
references: Gut. 2011 Dec;60(12):1739-53
references: 21300624
references: Immunology. 2011 Aug;133(4):397-408
references: 21631495
references: Arthritis Rheumatol. 2014 May;66(5):1165-75
references: 24782180
references: Arthritis Rheum. 2010 Apr;62(4):929-39
references: 20131262
references: Nat Immunol. 2011 Jun;12(6):568-75
references: 21516111
references: Nat Immunol. 2011 Jun;12(6):560-7
references: 21516112
references: Arthritis Rheum. 2009 Jun;60(6):1647-56
references: 19479869
references: Trends Mol Med. 2009 May;15(5):199-207
references: 19362058
references: J Autoimmun. 2014 Jun;51:38-43
references: 24461537
references: J Biol Chem. 2007 Nov 30;282(48):34605-10
references: 17884812
references: Inflamm Bowel Dis. 2008 Apr;14(4):437-45
references: 18088064
references: Eur J Immunol. 2010 Aug;40(8):2340-8
references: 20540117
references: Am J Pathol. 2009 Sep;175(3):1167-77
references: 19700754
references: J Immunol. 2009 Dec 1;183(11):7169-77
references: 19890056
references: Nat Immunol. 2009 Jun;10(6):603-9
references: 19448631
references: Arthritis Res Ther. 2013 Aug 23;15(4):R97
references: 23968496
references: Gut. 2003 Jan;52(1):65-70
references: 12477762
references: Nature. 2006 May 11;441(7090):231-4
references: 16648837
references: J Biol Chem. 2008 Jun 20;283(25):17003-8
references: 18434325
references: Inflamm Bowel Dis. 2006 May;12(5):382-8
references: 16670527
references: Nat Immunol. 2005 Nov;6(11):1133-41
references: 16200068
references: J Autoimmun. 2012 Sep;39(3):229-33
references: 22709856
references: Inflamm Bowel Dis. 2013 Mar-Apr;19(4):729-39
references: 23448791
references: Immunity. 2008 Jan;28(1):29-39
references: 18164222
references: Arthritis Res Ther. 2010;12(5):R184
references: 20929536
references: Ther Adv Musculoskelet Dis. 2013 Jun;5(3):141-52
references: 23858337
references: Autoimmun Rev. 2012 Oct;11(12 ):856-62
references: 22415021
references: Ann Rheum Dis. 2014 Jul;73(7):e43
references: 24728181
references: Nature. 2008 Jun 19;453(7198):1051-7
references: 18563156
references: Autoimmunity. 2011 May;44(3):243-52
references: 20925596
references: Arthritis Res Ther. 2010;12(2):R53
references: 20334681
references: Arthritis Res Ther. 2011 Jul 06;13(4):227
references: 21745420
references: Ann Rheum Dis. 2012 Feb;71(2):295-301
references: 21979002
references: N Engl J Med. 2007 Feb 8;356(6):580-92
references: 17287478
references: Clin Rheumatol. 2011 Sep;30(9):1201-7
references: 21874405
references: J Immunol. 2014 Jun 15;192(12):5610-7
references: 24850724
references: Inflamm Bowel Dis. 2012 Feb;18(2):368-71
references: 21538717
references: Nature. 2003 Feb 13;421(6924):744-8
references: 12610626
references: Cytokine. 2012 Oct;60(1):143-9
references: 22819243
references: Cancer Res. 2014 Sep 15;74(18):4955-66
references: 25172841
references: J Immunol. 2011 Jun 1;186(11):6313-8
references: 21531892
references: Annu Rev Immunol. 2010;28:573-621
references: 20192811
references: Nature. 2013 Apr 25;496(7446):518-22
references: 23467095
references: Int Rev Immunol. 2013 Oct-Dec;32(5-6):526-33
references: 24041379
references: Nat Immunol. 2009 May;10(5):514-23
references: 19305396
references: J Biol Chem. 2014 Sep 12;289(37):25546-55
references: 25070893
references: Arthritis Res Ther. 2011;13(5):R150
references: 21933391
references: Nat Immunol. 2007 Sep;8(9):913-9
references: 17712344
references: Immunity. 2008 Apr;28(4):454-67
references: 18400188
references: J Immunol. 2014 Sep 1;193(5):2168-77
references: 25063876