title: Simple Colorimetric Detection of Amyloid β-peptide (1-40) based on Aggregation of Gold Nanoparticles in the Presence of Copper Ions.
abstract: A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid-β peptide (Aβ) is developed based on the aggregation of gold nanoparticles in the presence of copper ion. The detection of limit for Aβ(1-40) is 0.6 nM and the promising results from practical samples (human serum) indicate the great potential for the routine detection.
authors: Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, China.
authors: Yanli
authors: Y
authors: Zhou
authors: Hui
authors: H
authors: Dong
authors: Lantao
authors: L
authors: Liu
authors: Maotian
authors: M
authors: Xu
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods; D002413:Cations, Divalent; D003124:Colorimetry / Q000379:methods*; D003300:Copper; D006046:Gold; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010446:Peptide Fragments / Q000032:analysis* / Q000097:blood; D013053:Spectrophotometry
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D002413:Cations, Divalent; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D006046:Gold; D003300:Copper
keywords: amyloid β-peptide; colorimetric sensor; copper ion; gold nanoparticles