title: Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population.
abstract: OBJECTIVE
  To explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population.
  
  
  METHODS
  Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
  
  
  RESULTS
  The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45).
  
  
  CONCLUSIONS
  In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB.
authors: Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara - Adam Malik Hospital, Medan, Indonesia.
authors: Bintang Y M
authors: BY
authors: Sinaga
authors: Muhammad
authors: M
authors: Amin
authors: Yahwardiah
authors: Y
authors: Siregar
authors: Sori M
authors: SM
authors: Sarumpaet
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007214:Indonesia / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human