title: SecReT6: a web-based resource for type VI secretion systems found in bacteria.
abstract: SecReT6 (http://db-mml.sjtu.edu.cn/SecReT6/) is an integrated database providing comprehensive information on type VI secretion systems (T6SSs) in bacteria. T6SSs are a class of sophisticated cell contact-dependent apparatuses involved in mediating antagonistic or synergistic communications between bacteria and/or bacteria and eukaryotes. These apparatuses have recently been found to be widely distributed among Gram-negative bacterial species. SecReT6 offers a unique, readily explorable archive of known and putative T6SSs, and cognate effectors found in bacteria. It currently contains data on 11 167 core T6SS components mapping to 906 T6SSs found in 498 bacterial strains representing 240 species, as well as a collection of over 600 directly relevant references. Also collated and archived were 1340 diverse candidate secreted effectors which were experimentally shown and/or predicted to be delivered by T6SSs into target eukaryotic and/or prokaryotic cells as well as 196 immunity proteins. A broad range of T6SS gene cluster detection and comparative analysis tools are readily accessible via SecReT6, which may aid identification of effectors and immunity proteins around the T6SS core components. This database will be regularly updated to ensure its ongoing maximal utility and relevance to the scientific research community.
authors: State Key Laboratory for Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200030, China.
authors: Jun
authors: J
authors: Li
authors: Laboratory of Bacterial Pathogenesis, Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
authors: Yufeng
authors: Y
authors: Yao
authors: Department of Biological Sciences, California State University, Los Angeles, CA, 90032, USA.
authors: H Howard
authors: HH
authors: Xu
authors: Quartermaster Equipment Institute of the General Logistics Department, People's Liberation Army, Beijing, 100010, China.
authors: Limin
authors: L
authors: Hao
authors: State Key Laboratory for Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200030, China.
authors: Zixin
authors: Z
authors: Deng
authors: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 9HN, UK.
authors: Kumar
authors: K
authors: Rajakumar
authors: State Key Laboratory for Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200030, China.
authors: Hong-Yu
authors: HY
authors: Ou
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D016208:Databases, Factual; D006090:Gram-Negative Bacteria / Q000502:physiology*; D020407:Internet; D005810:Multigene Family; D000069376:Type VI Secretion Systems / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D000069376:Type VI Secretion Systems