title: Mechanisms of inflammasome activation: recent advances and novel insights.
abstract: Inflammasomes are cytosolic multiprotein platforms assembled in response to invading pathogens and other danger signals. Typically inflammasome complexes contain a sensor protein, an adaptor protein, and a zymogen - procaspase-1. Formation of inflammasome assembly results in processing of inactive procaspase-1 into an active cysteine-protease enzyme, caspase-1, which subsequently activates the proinflammatory cytokines, interleukins IL-1β and IL-18, and induces pyroptosis, a highly-pyrogenic inflammatory form of cell death. Studies over the past year have unveiled exciting new players and regulatory pathways that are involved in traditional inflammasome signaling, some of them even challenging the existing dogma. This review outlines these new insights in inflammasome research and discusses areas that warrant further exploration.
authors: Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
authors: Sivapriya K
authors: SK
authors: Vanaja
authors: Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
authors: Vijay A K
authors: VA
authors: Rathinam
authors: Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, 7491 Trondheim, Norway. Electronic address: kate.fitzgerald@umassmed.edu.
authors: Katherine A
authors: KA
authors: Fitzgerald
mesh_terms: D000818:Animals; D020170:Caspase 1 / Q000378:metabolism*; D016923:Cell Death; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D020382:Interleukin-18 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D020170:Caspase 1
keywords: ALRs; NLRs; caspase-11; inflammasomes; non-canonical inflammasome
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