title: Pathology diagnosis of pancreatic neuroendocrine tumors.
abstract: Histopathology of pancreatic neuroendocrine tumors (PNETs) typically displays characteristic features. However, pathologists may encounter histological variants that may resemble other pancreatic tumors. Immunohistochemistry is a powerful tool in confirming neuroendocrine differentiation and differentiating PNETs with other pancreatic neoplasms. Histopathological features could be associated with inherited syndromes. Once the pathology diagnosis of neuroendocrine tumor was made, an accurate grading based on World Health Organization (WHO) classification is required. This review will focus on histology variants, immunohistochemistry and WHO classification of PNET.
authors: Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors: Atsuko
authors: A
authors: Kasajima
authors: Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
authors: Samaneh
authors: S
authors: Yazdani
authors: Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan.|Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
authors: Hironobu
authors: H
authors: Sasano
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading; D018358:Neuroendocrine Tumors / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*
keywords: Histopathology; Immunohistochemistry; Pancreatic neuroendocrine tumor