title: A novel New Delhi metallo-β-lactamase variant, NDM-14, isolated in a Chinese Hospital possesses increased enzymatic activity against carbapenems.
abstract: A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-14, was identified in clinical isolate Acinetobacter lwoffii JN49-1, which was recovered from an intensive care unit patient at a local hospital in China. NDM-14, which differs from other existing enzymes by an amino acid substitution at position 130 (Asp130Gly), possesses enzymatic activity toward carbapenems that is greater than that of NDM-1. Kinetic data indicate that NDM-14 has a higher affinity for imipenem and meropenem.
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Dayang
authors: D
authors: Zou
authors: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors: Yong
authors: Y
authors: Huang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Xiangna
authors: X
authors: Zhao
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Wei
authors: W
authors: Liu
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Derong
authors: D
authors: Dong
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Huan
authors: H
authors: Li
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Xuesong
authors: X
authors: Wang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Simo
authors: S
authors: Huang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Xiao
authors: X
authors: Wei
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Xiabei
authors: X
authors: Yan
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Zhan
authors: Z
authors: Yang
authors: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
authors: Yigang
authors: Y
authors: Tong
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China yuanjing6216@163.com huangliuyuly@163.com.
authors: Liuyu
authors: L
authors: Huang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China yuanjing6216@163.com huangliuyuly@163.com.
authors: Jing
authors: J
authors: Yuan
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000382:microbiology; D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000378:metabolism; D002681:China; D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D015378:Imipenem / Q000378:metabolism; D007362:Intensive Care Units; D007700:Kinetics; D000077731:Meropenem; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D013845:Thienamycins / Q000378:metabolism; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D000077731:Meropenem
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