title: Decoupled fluorescence Monte Carlo model for direct computation of fluorescence in turbid media.
abstract: We present a decoupled fluorescence Monte Carlo (dfMC) model for the direct computation of the fluorescence in turbid media. By decoupling the excitation-to-emission conversion and transport process of the fluorescence from the path probability density function and associating the corresponding parameters involving the fluorescence process with the weight function, the dfMC model employs the path histories of the excitation photons and the corresponding new weight function to directly calculate the fluorescence. We verify the model’s accuracy using phantom experiments and compare it with that of the perturbation fluorescence Monte Carlo model. The results indicate that the model is accurate for the direct fluorescence calculation and, thus, has great potential for application in fluorescence-based in vivo tomography.
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Zhaoyang
authors: Z
authors: Luo
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Yong
authors: Y
authors: Deng
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Kan
authors: K
authors: Wang
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Lichao
authors: L
authors: Lian
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Xiaoquan
authors: X
authors: Yang
authors: Huazhong University of Science and Technology-Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, 1037 Luo Yu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi.
authors: Qingming
authors: Q
authors: Luo
mesh_terms: D003198:Computer Simulation; D009010:Monte Carlo Method; D009391:Nephelometry and Turbidimetry; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence / Q000379:methods*