title: sVCAM-1 concentration and carotid IMT values in patients with acute myocardial infarction--Atherosclerotic markers of the presence, progress and prognosis.
abstract: OBJECTIVE
  Vascular cell adhesion molecule 1 (VCAM-1) plays a role in the adhesion and migration of leukocytes from blood to arterial intima and correlate with the development of atherosclerosis. The aim of the study was to establish whether soluble VCAM-1 (sVCAM-1) may act as an independent risk factor of coronary artery disease occurrence and whether it may reflect a degree of its advancement, if sVCAM-1 has a potential relation with intima-media thickness measurement (IMT), if sVCAM-1 may be useful as a predictor of further cardiovascular events.
  
  
  METHODS
  The study group was composed of 78 patients who were consecutively hospitalized in 2010-2011 due to myocardial infarction (MI). Selected clinical and biochemical risk factors were assessed, sVCAM-1 concentrations and IMT were measured.
  
  
  RESULTS
  Concentrations of sVCAM-1 were significantly higher in the study group as compared to the healthy controls. No significant dependence between sVCAM-1 concentration and the value of IMT in carotid arteries was found. There were no significantly statistical differences between the advancement of coronary artery changes and sVCAM-1 concentration. During the follow-up that lasted from 2 to 4 years (average period - 2.8 years), 4 patients died in the study group (5.1%). sVCAM-1 concentrations (but not IMT values) were significantly statistically higher in the group of patients who died (2248.5±443.5 vs. 990.2±433.6, p=0.0003).
  
  
  CONCLUSIONS
  sVCAM-1 concentrations are useful indicators of the presence of atherosclerosis in coronary arteries, but not its advancement. sVCAM-1 (but not IMT) can be a predictive indicator of an increased risk of death during follow-up in patients after myocardial infarction.
authors: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. Electronic address: anlila@poczta.onet.pl.
authors: Anna
authors: A
authors: Lisowska
authors: Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors: Elżbieta
authors: E
authors: Siergiejko
authors: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
authors: Agnieszka
authors: A
authors: Tycińska
authors: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
authors: Małgorzata
authors: M
authors: Knapp
authors: Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors: Halina
authors: H
authors: Kemona
authors: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
authors: Włodzimierz J
authors: WJ
authors: Musiał
authors: Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors: Violetta
authors: V
authors: Dymicka-Piekarska
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology; D002339:Carotid Arteries / Q000378:metabolism / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1
keywords: Carotid intima-media thickness; Myocardial infarction; sVCAM-1