title: [Comparison of diagnostic performance of two tests of premature rupture of membranes (IGFBP-1/PAMG-1) in clinical practice].
abstract: OBJECTIVE
  Evaluate the two main immunochromatographic tests of premature rupture of membranes (PROM): Actimprom(®) based on the discovery of insulin-like growth factor binding protein-1 (IGFBP-1) and Amnisure(®) based on the discovery of placental alpha 1-microglobulin (PAMG -1). The comparison was made voluntarily in clinical practice and is interested in a population whose failure is not clean break.
  
  
  METHODS
  Prospective and comparative study performed on 2012, at the university hospital of Caen, in 85 patients with PROM suspected between 24 SA and 36 SA. The presence of blood, semen or vaginal infection has been notified. Frank rupture of membranes was an exclusion criterion.
  
  
  RESULTS
  Actimprom(®) and Amnisure(®) were detected PROM with a specificity, sensitivity, PPV and NPV respectively 89.4% (CI 79.4-95.6%), 68.4% (CI 43.5-87.4%), 65% (CI 40.8-84.6%) and 90.8% (CI 81-96.5%). The results of both tests were not influenced by the presence of blood or inflammatory disease.
  
  
  CONCLUSIONS
  Performance of these tests is probably related to the quality of the sample and the extraction step in bed of the patient. This work showed no significant difference between the two tests in terms of performance in the diagnosis of PROM. At present, there is no formally favor the use of one or the other.
authors: Service de gynécologie-obstétrique, hôpital Femme-Enfant-Hématologie, avenue de la Côte-de-Nacre, 14033 Caen, France. Electronic address: mathildelecerf@hotmail.fr.
authors: M
authors: M
authors: Lecerf
authors: Service de gynécologie-obstétrique, hôpital Femme-Enfant-Hématologie, avenue de la Côte-de-Nacre, 14033 Caen, France.
authors: D
authors: D
authors: Vardon
authors: Unité de biostatistique et recherche clinique, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France.
authors: R
authors: R
authors: Morello
authors: Service de gynécologie-obstétrique, hôpital Femme-Enfant-Hématologie, avenue de la Côte-de-Nacre, 14033 Caen, France.
authors: N
authors: N
authors: Lamendour
authors: Service de gynécologie-obstétrique, hôpital Femme-Enfant-Hématologie, avenue de la Côte-de-Nacre, 14033 Caen, France.
authors: M
authors: M
authors: Dreyfus
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1
keywords: Amniotic fluid; Insulin-like growth factor binding protein-1 (IGFBP-1); Liquide amniotique; Placental alpha 1-microglobulin (PAMG-1); Premature rupture of fetal membranes; Rupture prématurée des membranes