title: Condensin-mediated chromosome organization and gene regulation.
abstract: In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation is achieved by the dosage compensation complex (DCC) binding to both X chromosomes in hermaphrodites to downregulate gene expression by twofold. The DCC contains a subcomplex (condensin I(DC)) similar to the evolutionarily conserved condensin complexes which play a fundamental role in chromosome dynamics during mitosis. Therefore, mechanisms related to mitotic chromosome condensation are hypothesized to mediate dosage compensation. Consistent with this hypothesis, monomethylation of histone H4 lysine 20 is increased, whereas acetylation of histone H4 lysine 16 is decreased, both on mitotic chromosomes and on interphase dosage compensated X chromosomes in worms. These observations suggest that interphase dosage compensated X chromosomes maintain some characteristics associated with condensed mitotic chromosome. This chromosome state is stably propagated from one cell generation to the next. In this review we will speculate on how the biochemical activities of condensin can achieve both mitotic chromosome compaction and gene repression.
authors: Department of Molecular, Cellular and Developmental Biology, University of Michigan Ann Arbor, MI, USA.
authors: Alyssa C
authors: AC
authors: Lau
authors: Department of Molecular, Cellular and Developmental Biology, University of Michigan Ann Arbor, MI, USA.
authors: Györgyi
authors: G
authors: Csankovszki
keywords: Caenorhabditis elegans; chromatin; chromosome condensation; condensin; dosage compensation; epigenetics; gene expression; interphase chromosome
references: PLoS Genet. 2012;8(8):e1002873
references: 22956908
references: Science. 1996 Dec 6;274(5293):1732-6
references: 8939869
references: PLoS Genet. 2008 Oct;4(10):e1000228
references: 18927632
references: J Cell Sci. 2011 Nov 1;124(Pt 21):3684-94
references: 22025633
references: EMBO J. 2011 Jan 19;30(2):263-76
references: 21169989
references: Nature. 2010 Jul 22;466(7305):508-12
references: 20622854
references: Science. 2014 Jan 3;343(6166):77-80
references: 24385627
references: Genes Dev. 2008 Jan 15;22(2):194-211
references: 18198337
references: J Biol Chem. 2001 Feb 23;276(8):5417-20
references: 11136719
references: Nat Genet. 2011 Oct 23;43(12):1179-85
references: 22019781
references: Cell. 1997 May 16;89(4):511-21
references: 9160743
references: PLoS Biol. 2007 Dec;5(12):e326
references: 18076287
references: EMBO J. 2006 Nov 15;25(22):5339-48
references: 17066080
references: J Cell Biol. 2000 May 15;149(4):811-24
references: 10811823
references: Genes Dev. 2011 Jul 15;25(14):1464-9
references: 21715560
references: J Cell Biol. 2010 Feb 22;188(4):491-503
references: 20176923
references: Genome Biol. 2013;14(10):R112
references: 24125077
references: Curr Biol. 2006 Feb 21;16(4):333-44
references: 16488867
references: J Cell Biol. 2004 Nov 22;167(4):613-25
references: 15557118
references: Science. 1998 Oct 16;282(5388):487-90
references: 9774278
references: Genes Dev. 2006 Jul 15;20(14):1848-67
references: 16847345
references: Science. 2013 Nov 22;342(6161):948-53
references: 24200812
references: Mol Cell Biol. 2012 May;32(9):1710-9
references: 22393255
references: PLoS Genet. 2012 Sep;8(9):e1002933
references: 23028348
references: J Cell Sci. 2012 Mar 15;125(Pt 6):1591-604
references: 22344259
references: J Biol. 2006;5(1):3
references: 16507155
references: PLoS Genet. 2012;8(5):e1002667
references: 22589731
references: Chromosome Res. 2009;17(5):621-35
references: 19802703
references: Cell. 1998 Jan 23;92(2):265-77
references: 9458050
references: Development. 2012 Jun;139(12):2085-9
references: 22619385
references: Mol Cell. 2009 May 14;34(4):416-26
references: 19481522
references: Nat Struct Mol Biol. 2014 Feb;21(2):118-25
references: 24500429
references: Mol Biol Cell. 2010 Jan 15;21(2):254-65
references: 19910488
references: Cell. 1994 Nov 4;79(3):449-58
references: 7954811
references: Genome Biol. 2014 Jun 30;15(6):R82
references: 24981874
references: Nat Genet. 2011 Nov 28;43(12):1169-70; author reply 1171-2
references: 22120049
references: Annu Rev Genet. 2008;42:733-72
references: 18729722
references: Cell. 1999 Jul 23;98(2):239-48
references: 10428035
references: Nature. 2008 Jul 17;454(7202):297-301
references: 18596691
references: Cell. 2003 Oct 3;115(1):109-21
references: 14532007
references: Curr Opin Genet Dev. 2010 Apr;20(2):179-89
references: 20381335
references: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11972-7
references: 11027308
references: Cell. 1997 Aug 22;90(4):625-34
references: 9288743
references: Science. 2008 Nov 28;322(5906):1384-7
references: 19039137
references: Nat Commun. 2013;4:2537
references: 24088984
references: Science. 2011 Mar 11;331(6022):1328-32
references: 21393545
references: Nat Rev Genet. 2012 Jan 18;13(2):123-34
references: 22251873
references: Mol Cell. 2002 Jun;9(6):1201-13
references: 12086618
references: Genes Dev. 2002 Mar 15;16(6):729-42
references: 11914278
references: Mol Biol Cell. 2004 Jul;15(7):3296-308
references: 15146063
references: Epigenetics Chromatin. 2014 Oct 27;7(1):31
references: 25400696
references: Genes Dev. 2002 Sep 1;16(17):2225-30
references: 12208845
references: Leukemia. 2006 Jul;20(7):1261-9
references: 16673016
references: Dev Cell. 2013 Apr 15;25(1):55-68
references: 23523075
references: Genes Dev. 2008 Aug 15;22(16):2204-14
references: 18708579
references: Cell. 2009 Oct 2;139(1):73-86
references: 19781752
references: J Cell Sci. 2004 Dec 15;117(Pt 26):6435-45
references: 15572404
references: Mol Cell Biol. 2009 Apr;29(8):2278-95
references: 19223465
references: Genes Dev. 1999 Sep 1;13(17):2271-83
references: 10485849
references: Mol Biol Cell. 2011 Sep;22(18):3465-77
references: 21795393
references: Cell. 1994 Nov 4;79(3):459-74
references: 7954812
references: J Cell Biol. 2013 Apr 1;201(1):49-63
references: 23530065
references: Curr Biol. 2009 Jan 13;19(1):9-19
references: 19119011
references: Genes Dev. 2012 Aug 1;26(15):1659-78
references: 22855829
references: Science. 2006 Feb 10;311(5762):844-7
references: 16469925
references: Nat Struct Mol Biol. 2011 Jul 17;18(8):894-901
references: 21765419
references: EMBO J. 2003 Jun 2;22(11):2764-75
references: 12773391
references: Nature. 2013 Oct 3;502(7469):45-6
references: 24067607