title: New loci and coding variants confer risk for age-related macular degeneration in East Asians.
abstract: Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The Genetics of AMD in Asians (GAMA) Consortium. We find a strong association between CETP Asp442Gly (rs2303790), an East Asian-specific mutation, and increased risk of AMD (odds ratio (OR)=1.70, P=5.60 × 10(-22)). The AMD risk allele (442Gly), known to protect from coronary heart disease, increases HDL cholesterol levels by 0.17 mmol l(-1) (P=5.82 × 10(-21)) in East Asians (n=7,102). We also identify three novel AMD loci: C6orf223 Ala231Ala (OR=0.78, P=6.19 × 10(-18)), SLC44A4 Asp47Val (OR=1.27, P=1.08 × 10(-11)) and FGD6 Gln257Arg (OR=0.87, P=2.85 × 10(-8)). Our findings suggest that some of the genetic loci conferring AMD susceptibility in East Asians are shared with Europeans, yet AMD in East Asians may also have a distinct genetic signature.
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [4] Singapore National Eye Center, Singapore 168751, Singapore.
authors: Ching-Yu
authors: CY
authors: Cheng
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Kenji
authors: K
authors: Yamashiro
authors: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors: Li Jia
authors: LJ
authors: Chen
authors: Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 156-707, Korea.
authors: Jeeyun
authors: J
authors: Ahn
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Lulin
authors: L
authors: Huang
authors: 1] Key Laboratory of Vision Loss and Restoration, Ministry of Education of China, Beijing 100044, China [2] Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100871, China [3] Department of Ophthalmology, People's Hospital, Peking University, Beijing 100871, China.
authors: Lvzhen
authors: L
authors: Huang
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Singapore National Eye Center, Singapore 168751, Singapore.
authors: Chui Ming G
authors: CM
authors: Cheung
authors: 1] Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan [2] Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Masahiro
authors: M
authors: Miyake
authors: 1] Singapore National Eye Center, Singapore 168751, Singapore [2] Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA, UK.
authors: Peter D
authors: PD
authors: Cackett
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Ian Y
authors: IY
authors: Yeo
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore.
authors: Augustinus
authors: A
authors: Laude
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Ranjana
authors: R
authors: Mathur
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Junxiong
authors: J
authors: Pang
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Kar Seng
authors: KS
authors: Sim
authors: 1] Singapore National Eye Center, Singapore 168751, Singapore [2] Eye and Retinal Surgeons, Camden Medical Centre, Singapore 248649, Singapore.
authors: Adrian H
authors: AH
authors: Koh
authors: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Peng
authors: P
authors: Chen
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Shu Yen
authors: SY
authors: Lee
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Doric
authors: D
authors: Wong
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Choi Mun
authors: CM
authors: Chan
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Boon Kwang
authors: BK
authors: Loh
authors: 1] Key Laboratory of Vision Loss and Restoration, Ministry of Education of China, Beijing 100044, China [2] Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100871, China [3] Department of Ophthalmology, People's Hospital, Peking University, Beijing 100871, China.
authors: Yaoyao
authors: Y
authors: Sun
authors: 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [2] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Sonia
authors: S
authors: Davila
authors: 1] Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan [2] Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Isao
authors: I
authors: Nakata
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Hideo
authors: H
authors: Nakanishi
authors: 1] Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan [2] Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Yumiko
authors: Y
authors: Akagi-Kurashige
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Norimoto
authors: N
authors: Gotoh
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Fumihiko
authors: F
authors: Matsuda
authors: Department of Ophthalmology, Saitama Medical University, Iruma 3500495, Japan.
authors: Keisuke
authors: K
authors: Mori
authors: Department of Ophthalmology, Saitama Medical University, Iruma 3500495, Japan.
authors: Shin
authors: S
authors: Yoneya
authors: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi 4093898, Japan.
authors: Yoichi
authors: Y
authors: Sakurada
authors: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi 4093898, Japan.
authors: Hiroyuki
authors: H
authors: Iijima
authors: Department of Ophthalmology, Tokyo Women's Medical University Hospital, Tokyo 1628666, Japan.
authors: Tomohiro
authors: T
authors: Iida
authors: Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan.
authors: Shigeru
authors: S
authors: Honda
authors: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors: Timothy Yuk Yau
authors: TY
authors: Lai
authors: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors: Pancy Oi Sin
authors: PO
authors: Tam
authors: 1] Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China [2] Shantou University/Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou 515041, China.
authors: Haoyu
authors: H
authors: Chen
authors: 1] Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China [2] Aier School of Ophthalmology, Central South University, Changsha 410000, China.
authors: Shibo
authors: S
authors: Tang
authors: Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors: Xiaoyan
authors: X
authors: Ding
authors: Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors: Feng
authors: F
authors: Wen
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Fang
authors: F
authors: Lu
authors: Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors: Xiongze
authors: X
authors: Zhang
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Yi
authors: Y
authors: Shi
authors: Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
authors: Peiquan
authors: P
authors: Zhao
authors: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing 100730, China.
authors: Bowen
authors: B
authors: Zhao
authors: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing 100730, China.
authors: Jinghong
authors: J
authors: Sang
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Bo
authors: B
authors: Gong
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Rajkumar
authors: R
authors: Dorajoo
authors: 1] Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15260, USA [2] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors: Jian-Min
authors: JM
authors: Yuan
authors: 1] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Woon-Puay
authors: WP
authors: Koh
authors: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Rob M
authors: RM
authors: van Dam
authors: Hebrew University, School of Public Health, Jerusalem 91120, Israel.
authors: Yechiel
authors: Y
authors: Friedlander
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Ying
authors: Y
authors: Lin
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Martin L
authors: ML
authors: Hibberd
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Jia Nee
authors: JN
authors: Foo
authors: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing 100730, China.
authors: Ningli
authors: N
authors: Wang
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Chang Hua
authors: CH
authors: Wong
authors: Singapore National Eye Center, Singapore 168751, Singapore.
authors: Gavin S
authors: GS
authors: Tan
authors: Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi 463-707, Korea.
authors: Sang Jun
authors: SJ
authors: Park
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
authors: Mayuri
authors: M
authors: Bhargava
authors: Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
authors: Lingam
authors: L
authors: Gopal
authors: Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
authors: Thet
authors: T
authors: Naing
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
authors: Jiemin
authors: J
authors: Liao
authors: Singapore Eye Research Institute, Singapore 169856, Singapore.
authors: Peng Guan
authors: PG
authors: Ong
authors: Department of Ophthalmology, University of Sydney and Westmead Millennium Institute, Sydney 2145, Australia.
authors: Paul
authors: P
authors: Mitchell
authors: Eye and ENT Hospital of Fudan University, Shanghai 200433, China.
authors: Peng
authors: P
authors: Zhou
authors: BGI-Shenzhen, Shenzhen 518083, China.
authors: Xuefeng
authors: X
authors: Xie
authors: BGI-Shenzhen, Shenzhen 518083, China.
authors: Jinlong
authors: J
authors: Liang
authors: BGI-Shenzhen, Shenzhen 518083, China.
authors: Junpu
authors: J
authors: Mei
authors: BGI-Shenzhen, Shenzhen 518083, China.
authors: Xin
authors: X
authors: Jin
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [4] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Seang-Mei
authors: SM
authors: Saw
authors: Ozaki Eye Hospital, Miyazaki 8830066, Japan.
authors: Mineo
authors: M
authors: Ozaki
authors: Mizoguchi Eye Hospital, Nagasaki 8570016, Japan.
authors: Takanori
authors: T
authors: Mizoguchi
authors: Department of Ophthalmology, Kobe City General Hospital, Kobe 6500046, Japan.
authors: Yasuo
authors: Y
authors: Kurimoto
authors: 1] Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi 463-707, Korea [2] Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-744, Korea.
authors: Se Joon
authors: SJ
authors: Woo
authors: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-744, Korea.
authors: Hum
authors: H
authors: Chung
authors: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-744, Korea.
authors: Hyeong-Gon
authors: HG
authors: Yu
authors: Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-744, Korea.
authors: Joo Young
authors: JY
authors: Shin
authors: Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 700-721, Korea.
authors: Dong Ho
authors: DH
authors: Park
authors: Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 700-721, Korea.
authors: In Taek
authors: IT
authors: Kim
authors: Department of Ophthalmology, Yeungnam University College of Medicine, Daegu 705-802, Korea.
authors: Woohyok
authors: W
authors: Chang
authors: Department of Ophthalmology, Yeungnam University College of Medicine, Daegu 705-802, Korea.
authors: Min
authors: M
authors: Sagong
authors: Department of Ophthalmology, College of Medicine, Kosin University, Pusan 606-701, Korea.
authors: Sang-Joon
authors: SJ
authors: Lee
authors: Department of Ophthalmology, Pusan Paik Hospital, Inje University College of Medicine, Pusan 614-735, Korea.
authors: Hyun Woong
authors: HW
authors: Kim
authors: 1] Department of Ophthalmology, Pusan National University Hospital, Pusan 602-739, Korea [2] Medical Research Institute, Pusan National University, Pusan 602-739, Korea.
authors: Ji Eun
authors: JE
authors: Lee
authors: Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
authors: Yi
authors: Y
authors: Li
authors: 1] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Jianjun
authors: J
authors: Liu
authors: 1] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Yik Ying
authors: YY
authors: Teo
authors: Department of Pediatrics, National University Health System and National University of Singapore, Singapore 119228, Singapore.
authors: Chew Kiat
authors: CK
authors: Heng
authors: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore.
authors: Tock Han
authors: TH
authors: Lim
authors: Department of Gastroenterology, Asan Medical Center and University of Ulsan College of Medicine, Seoul 138-736, Korea.
authors: Suk-Kyun
authors: SK
authors: Yang
authors: Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea.
authors: Kyuyoung
authors: K
authors: Song
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
authors: Eranga N
authors: EN
authors: Vithana
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [3] Singapore National Eye Center, Singapore 168751, Singapore.
authors: Tin
authors: T
authors: Aung
authors: 1] State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China [2] Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou 510080, China.
authors: Jin Xin
authors: JX
authors: Bei
authors: 1] State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China [2] Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou 510080, China [3] Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
authors: Yi Xin
authors: YX
authors: Zeng
authors: 1] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore [3] Department of Medicine, National University Health System and National University of Singapore, Singapore 119228, Singapore.
authors: E Shyong
authors: ES
authors: Tai
authors: 1] Key Laboratory of Vision Loss and Restoration, Ministry of Education of China, Beijing 100044, China [2] Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100871, China [3] Department of Ophthalmology, People's Hospital, Peking University, Beijing 100871, China.
authors: Xiao Xin
authors: XX
authors: Li
authors: 1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
authors: Zhenglin
authors: Z
authors: Yang
authors: Department of Ophthalmology, Seoul National University Bundang Hospital, Gyeonggi 463-707, Korea.
authors: Kyu-Hyung
authors: KH
authors: Park
authors: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors: Chi Pui
authors: CP
authors: Pang
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
authors: Nagahisa
authors: N
authors: Yoshimura
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857, Singapore [3] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore [4] Singapore National Eye Center, Singapore 168751, Singapore.
authors: Tien Yin
authors: TY
authors: Wong
authors: 1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore [3] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
authors: Chiea Chuen
authors: CC
authors: Khor
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics; D059472:Exome / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008268:Macular Degeneration / Q000097:blood / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL
references: FEBS Lett. 2002 Jun 19;521(1-3):19-23
references: 12067718
references: Nature. 2012 Sep 6;489(7414):57-74
references: 22955616
references: Bioinformatics. 2003 Jan;19(1):149-50
references: 12499305
references: Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):160-7
references: 12588754
references: Nucleic Acids Res. 2003 Jul 1;31(13):3812-4
references: 12824425
references: Eur Heart J. 2003 Oct;24(20):1833-42
references: 14563342
references: Arch Ophthalmol. 1991 Sep;109(9):1220-31
references: 1718250
references: J Clin Invest. 1993 Oct;92(4):2060-4
references: 8408659
references: J Clin Invest. 1994 Nov;94(5):1872-82
references: 7962532
references: Nippon Ganka Gakkai Zasshi. 2005 Jul;109(7):417-27
references: 16050460
references: Nat Genet. 2007 Jul;39(7):906-13
references: 17572673
references: Am J Hum Genet. 2007 Sep;81(3):559-75
references: 17701901
references: Hum Mol Genet. 2007 Aug 15;16(16):1986-92
references: 17576744
references: Nat Genet. 2008 Feb;40(2):189-97
references: 18193044
references: Nat Genet. 2009 Jan;41(1):56-65
references: 19060906
references: PLoS Genet. 2009 Jun;5(6):e1000529
references: 19543373
references: Ophthalmic Epidemiol. 2009 Nov-Dec;16(6):325-36
references: 19995197
references: Prog Retin Eye Res. 2010 Jan;29(1):19-29
references: 19854291
references: Nat Methods. 2010 Apr;7(4):248-9
references: 20354512
references: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7401-6
references: 20385819
references: Graefes Arch Clin Exp Ophthalmol. 2010 Jul;248(7):931-6
references: 20221623
references: Genet Test Mol Biomarkers. 2010 Aug;14(4):533-7
references: 20642364
references: J Hypertens. 2009 Nov;27(11):2209-17
references: 19620884
references: Nat Genet. 2011 May;43(5):455-8
references: 21499248
references: Hum Mol Genet. 2011 Sep 15;20(18):3699-709
references: 21665990
references: Nat Genet. 2011 Oct;43(10):1001-4
references: 21909106
references: Biostatistics. 2012 Sep;13(4):762-75
references: 22699862
references: Nat Genet. 2012 Oct;44(10):1142-6
references: 22922875
references: Nat Genet. 2012 Oct;44(10):1131-6
references: 22961001
references: PLoS One. 2012;7(9):e46385
references: 23050023
references: Nat Genet. 2013 Feb;45(2):197-201
references: 23263489
references: Nat Genet. 2013 Apr;45(4):433-9, 439e1-2
references: 23455636
references: Nat Genet. 2013 Jul;45(7):813-7
references: 23685748
references: Nat Genet. 2013 Oct;45(10):1238-43
references: 24013639
references: Am J Ophthalmol. 2013 Nov;156(5):1002-1009.e2
references: 23938127
references: Nat Genet. 2013 Nov;45(11):1375-9
references: 24036949
references: Nat Genet. 2013 Nov;45(11):1371-4
references: 24036950
references: Nat Genet. 2013 Nov;45(11):1366-70
references: 24036952
references: Lancet Glob Health. 2014 Feb;2(2):e106-16
references: 25104651
references: Circulation. 2002 Nov 12;106(20):2526-9
references: 12427645
references: Nutr Cancer. 2001;39(2):187-95
references: 11759279
references: Nat Genet. 2011 Dec;43(12):1232-6
references: 22019782
references: Nat Genet. 2011 Dec;43(12):1241-6
references: 22081228
references: N Engl J Med. 2011 Dec 8;365(23):2237; author reply 2237
references: 22150050
references: Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
references: 22064851
references: Arch Ophthalmol. 2012 Apr;130(4):480-6
references: 22159171
references: Lancet. 2012 May 5;379(9827):1728-38
references: 22559899
references: Nat Genet. 2012 Aug;44(8):955-9
references: 22820512
references: Genome Res. 2012 Sep;22(9):1790-7
references: 22955989
references: Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):830-5
references: 10712410
references: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1835-40
references: 10677542