title: Relationship between serum insulin-like growth factor-1, IGF binding protein-3 levels and body height before and after gonadotropin-releasing hormone agonist therapy.
abstract: OBJECTIVE
  The gonadotropin-releasing hormone agonist (GnRHa) is widely used to treat patients with precocious puberty. However, its effect on growth is often difficult to predict because of the diverse nature of its causes and presentation. This study aims to show the impact of GnRHa treatment on insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) secretion, growth, and on other parameters that may help estimate the height velocity.
  
  
  METHODS
  Data from 60 girls (mean age, 8.8±0.7 years) treated with GnRHa were analyzed. Their height, bone age (BA), serum IGF-I, and IGFBP-3 concentrations were measured at the start and after a year of GnRHa treatment. To eliminate the confounding effect of chronological age (CA), the standard deviation scores (SDSs) of their height, IGF-I, and IGFBP-3 concentrations according to their CA at the start and after a year of GnRHa treatment were calculated. We looked for possible correlations between these variables and compared the subgroups based on their height velocities and midparental heights.
  
  
  RESULTS
  During their one-year GnRHa therapy, height SDS for CA significantly decreased to 0.81±0.83 (P<0.001), but height SDS for BA increased to -0.28±0.68 (P<0.001). There was no significant change in serum IGF-I SDS, IGFBP-3 SDS, and IGF-I/IGFBP-3 ratio. The advanced BA was the factor most strongly correlated to the height velocity (R=0.265, P=0.041).
  
  
  CONCLUSIONS
  These findings suggest that GnRHa treatment may affect the height velocity due to mechanisms other than suppression of the IGF-I and IGFBP-3 secretory axis.
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Han Sol
authors: HS
authors: Song
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Won Bok
authors: WB
authors: Choi
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Joon Sup
authors: JS
authors: Song
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Il Tae
authors: IT
authors: Hwang
authors: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors: Seung
authors: S
authors: Yang
keywords: Body height; Insulin-like growth factor I; Precocious puberty
references: J Clin Endocrinol Metab. 1981 Feb;52(2):370-2
references: 6780592
references: Korean J Lab Med. 2011 Oct;31(4):244-9
references: 22016677
references: J Clin Endocrinol Metab. 2004 Jan;89(1):103-7
references: 14715835
references: J Clin Endocrinol Metab. 1985 Jul;61(1):152-9
references: 3889035
references: Eur J Clin Nutr. 1990 Jan;44(1):45-60
references: 2354692
references: Horm Res. 1997;47(2):54-61
references: 9030968
references: J Clin Endocrinol Metab. 2006 May;91(5):1862-7
references: 16449344
references: Clin Biochem. 2012 Jan;45(1-2):16-21
references: 22032863
references: Clin Endocrinol (Oxf). 1996 Jul;45(1):7-12
references: 8796132
references: Clin Endocrinol (Oxf). 2002 Mar;56(3):297-302
references: 11940040
references: J Clin Endocrinol Metab. 1999 Oct;84(10):3575-8
references: 10522998
references: Hum Reprod Update. 2004 Mar-Apr;10(2):135-47
references: 15073143
references: J Clin Endocrinol Metab. 2011 May;96(5):1393-401
references: 21346077
references: Chonnam Med J. 2012 Apr;48(1):27-31
references: 22570812
references: Pediatrics. 2002 Jan;109(1):61-7
references: 11773542
references: J Clin Endocrinol Metab. 1991 Oct;73(4):734-8
references: 1909701
references: J Pediatr. 1989 Jul;115(1):64-8
references: 2738797
references: J Clin Endocrinol Metab. 1995 Feb;80(2):546-51
references: 7852518
references: Arch Dis Child. 1999 Oct;81(4):329-32
references: 10490438
references: Clin Endocrinol (Oxf). 2002 Feb;56(2):129-48
references: 11874402
references: Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6871-6
references: 11381135
references: Bone. 2000 Oct;27(4):495-501
references: 11033444
references: J Clin Endocrinol Metab. 1990 Oct;71(4):975-83
references: 2401720
references: J Clin Endocrinol Metab. 1991 Dec;73(6):1235-40
references: 1955504
references: J Clin Endocrinol Metab. 1991 Oct;73(4):902-6
references: 1909708
references: Med Sci Monit. 2011 Jun;17(6):PH41-8
references: 21629198