title: Characterization of solitary pulmonary nodules with 18F-FDG PET/CT relative activity distribution analysis.
abstract: OBJECTIVE
  To compare the capability of relative activity distribution (RAD), a new index of fluorodeoxyglucose F18 ((18)F-FDG) uptake, with those of the typical markers for differentiating benign and malignant solitary pulmonary nodules (SPNs) by integrated positron emission tomography (PET)/computed tomography (CT).
  
  
  METHODS
  RAD, maximal standardised uptake value (SUV(max)), partial volume corrected SUV(max) (corrSUV(max)), and retention index (RI) were calculated prospectively for 115 malignant and 60 benign SPNs. Area under receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy were compared (P < 0.05).
  
  
  RESULTS
  Malignant lesions (0.98 ± 0.03) had significantly lower RAD than benign lesions (1.01 ± 0.02). AUC (0.935) was significantly larger and specificity (96.67%) was significantly higher for RAD than for SUV(max) (P ≤ 0.0001), corrSUV(max) (P < 0.0001), RI (P < 0.0001), and visual assessment (P = 0.01 and 0.002, respectively). Further, RAD had significantly higher sensitivity (92.17%) than SUV(max) (P = 0.0007) and higher accuracy (93.71%) than SUV(max) (P < 0.0001), corrSUV(max) (P < 0.0001), and RI (P = 0.002).
  
  
  CONCLUSIONS
  RAD seems to be more specific and accurate than the typical markers for differentiating malignant and benign SPNs by (18)F-FDG PET/CT.
  
  
  CONCLUSIONS
  • Relative activity distribution index is assessable by (18)F-FDG PET/CT • The index effectively characterises solitary pulmonary nodules • RAD is more specific and accurate than the typical markers in (18)F-FDG PET/CT • RAD provides additional options for small solitary pulmonary nodules.
authors: Division of PET/CT, Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 325000.
authors: Liang
authors: L
authors: Zhao
authors: Li
authors: L
authors: Tong
authors: Jie
authors: J
authors: Lin
authors: Kun
authors: K
authors: Tang
authors: SiSi
authors: S
authors: Zheng
authors: WenFeng
authors: W
authors: Li
authors: DeZhi
authors: D
authors: Cheng
authors: WeiWei
authors: W
authors: Yin
authors: XiangWu
authors: X
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
references: Clin Chest Med. 1993 Mar;14 (1):111-9
references: 8462244
references: Science. 1956 Feb 24;123(3191):309-14
references: 13298683
references: Radiology. 2005 Nov;237(2):395-400
references: 16244247
references: Chest. 1987 Jan;91(1):128-33
references: 3792065
references: Clin Chest Med. 1992 Mar;13(1):83-95
references: 1582151
references: Nature. 2011 Apr 7;472(7341):90-4
references: 21399628
references: Lancet. 1986 Feb 8;1(8476):307-10
references: 2868172
references: Cancer Res. 1986 May;46(5):2203-7
references: 3516380
references: Chest. 1993 Oct;104(4):997-1002
references: 8404239
references: Radiology. 2004 May;231(2):305-32
references: 15044750
references: Nature. 2010 Oct 28;467(7319):1114-7
references: 20981102
references: Radiology. 2000 Jan;214(1):73-80
references: 10644104
references: Chest. 1996 Apr;109 (4):982-8
references: 8635381
references: Eur J Nucl Med Mol Imaging. 2002 Dec;29(12 ):1639-47
references: 12458399
references: J Nucl Med. 2002 Jul;43(7):871-5
references: 12097455
references: Radiology. 1993 Aug;188(2):487-90
references: 8327702
references: Br J Surg. 1998 Nov;85(11):1506-11
references: 9823912
references: JAMA. 2001 Feb 21;285(7):914-24
references: 11180735
references: Thorax. 1953 Jun;8(2):153-6
references: 13077512
references: J Nucl Med. 1998 Jul;39(7):1267-9
references: 9669408
references: Radiology. 1992 Aug;184(2):441-4
references: 1620844
references: Radiology. 2005 Nov;237(2):675-83
references: 16244276
references: Nat Med. 2011 Mar;17(3):320-9
references: 21383745
references: Science. 1982 Sep 10;217(4564):998-1003
references: 7112116
references: J Nucl Med. 1998 Jun;39(6):1016-20
references: 9627336
references: Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3949-54
references: 24594603
references: J Nucl Med. 1994 Aug;35(8):1308-12
references: 8046485
references: J Nucl Med. 2007 Jun;48(6):932-45
references: 17504879
references: N Engl J Med. 1956 May 31;254(22):1018-22
references: 13322204
references: Radiology. 1995 Feb;194(2):399-405
references: 7824717
references: J Nucl Med. 2004 Aug;45(8):1287-92
references: 15299050
references: Radiology. 2008 Mar;246(3):772-82
references: 18235105
references: J Clin Oncol. 1998 Mar;16(3):1075-84
references: 9508193
references: Radiology. 2011 Feb;258(2):599-609
references: 21273522
references: Trends Genet. 2009 Jan;25(1):30-8
references: 19054589
references: Radiology. 1996 Sep;200(3):681-6
references: 8756914
references: Eur J Nucl Med Mol Imaging. 2008 Feb;35(2):246-52
references: 17938921
references: Arch Surg. 1975 May;110(5):570-5
references: 1093512
references: J Nucl Med. 2001 Sep;42(9):1412-7
references: 11535734