title: A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol.
abstract: We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.
authors: Department of Anesthesiology and Pediatric Critical Care, and gilles.orliaguet@nck.aphp.fr.
authors: Gilles
authors: G
authors: Orliaguet
authors: Department of Anesthesiology and Pediatric Critical Care, and.
authors: Jamil
authors: J
authors: Hamza
authors: Pediatric Otolaryngology Department, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes, Assistance Publique des Hôpitaux de Paris, Paris, France;
authors: Vincent
authors: V
authors: Couloigner
authors: Pediatric Otolaryngology Department, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes, Assistance Publique des Hôpitaux de Paris, Paris, France;
authors: Françoise
authors: F
authors: Denoyelle
authors: Department of Biochemistry, Pharmacogenetics and Molecular Oncology Unit, Assistance Publique des Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR-S 1147, Paris, France; and.
authors: Marie-Anne
authors: MA
authors: Loriot
authors: Department of Toxicology and Genopathy, University of Lille Nord de France, Lille, France.
authors: Franck
authors: F
authors: Broly
authors: Pediatric Otolaryngology Department, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes, Assistance Publique des Hôpitaux de Paris, Paris, France;
authors: Erea Noel
authors: EN
authors: Garabedian
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D019389:Cytochrome P-450 CYP2D6 / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000201:enzymology / Q000209:etiology*; D014068:Tonsillectomy; D014147:Tramadol / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol; D019389:Cytochrome P-450 CYP2D6
keywords: respiratory depression; tramadol; ultrarapid CYP2D6