title: [Changes of the microarchitecture of alveolar bone due to different duration of ovariectomy: a Micro-CT study in rats].
abstract: OBJECTIVE
  To study the changes of microarchitecture of alveolar bone due to different duration of ovariectomy in rats.
  
  
  METHODS
  Twenty-four virgin Sprague-Dawley rats were randomly assigned to ovariectomy group (OVX) or sham-ovariectomy group (sham). OVX rats were subjected to bilateral ovariectomy and sham-ovariectomy was conducted in sham rats. Six rats of each group were sacrificed respectively 3 months and 6 months after surgery. The right semi-maxilla of all rats were scanned by Micro-CT, and the inter-radicular alveolar bone of the maxillary first molar was analyzed. Statistical analysis was carried out with SPSS 16.0 software package.
  
  
  RESULTS
  Two-dimensional and three-dimensional reconstructed images of the alveolar bone showed porotic changes in rats both 3 months and 6 months after ovariectomy, including thinner, looser trabeculae and expanded bone marrow. When compared with corresponding sham rats, BMD, BV/TV and Tb.Th of alveolar bone significantly decreased in OVX rats both 3 months and 6 months after ovariectomy (P<0.05). Tb.N and Tb.Sp significantly increased in both OVX groups (P<0.05). When compared with 3 months after ovariectomy, the rats 6 months after ovaroectomy shared deceased BMD, BV/TV and Tb.Th (P<0.05) and increased Tb.N (P<0.05).
  
  
  CONCLUSIONS
  Bone loss and deterioration of trabeculae of alveolar bone aggravates with the extended duration of ovariectomy in OVX rats.
authors: Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China.E-mail:daiqinggang@126.com.
authors: Qing-gang
authors: QG
authors: Dai
authors: Bing
authors: B
authors: Fang
authors: Peng
authors: P
authors: Zhang
authors: Xiao
authors: X
authors: Yang
authors: Jie
authors: J
authors: Wang
authors: Ning-juan
authors: NJ
authors: Ouyang
authors: Yu-qiong
authors: YQ
authors: Wu
authors: Ling-yong
authors: LY
authors: Jiang
mesh_terms: D000818:Animals; D015519:Bone Density; D005260:Female; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014057:Tomography, X-Ray Computed; D055114:X-Ray Microtomography