title: Steroid-resistant autoimmune thrombocytopenia in systemic lupus erythematosus treated with rituximab.
abstract: Systemic Lupus Erythematosus (SLE) is a multisystem disorder characterized by production of numerous autoantibodies, some of which have pathogenic consequences and result in considerable morbidity. Herein, we present a case of 48-year-old female with SLE having autoimmune hemolytic anemia, autoimmune thrombocytopenia, renal involvement, and recurrent flares of skin manifestations. She did not respond to the conventional therapy and was controlled and treated with Rituximab, a chimeric, monoclonal antiCD20 antibody, which specifically depletes B lymphocytes.
authors: Department of Medicine, Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India.
authors: Vasudha V
authors: VV
authors: Sardesai
authors: Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India.
authors: Vidyadhar R
authors: VR
authors: Sardesai
authors: Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India.
authors: Trupti D
authors: TD
authors: Agarwal
keywords: Rituximab; systemic lupus erythematous; thrombocytopenia
references: Rheumatology (Oxford). 2011 Sep;50(9):1640-4
references: 21571767
references: Ann Intern Med. 1992 Jun 15;116(12 Pt 1):977-81
references: 1586107
references: Ann Rheum Dis. 2002 May;61(5):409-13
references: 11959764
references: Arthritis Rheum. 2004 Aug;50(8):2580-9
references: 15334472
references: Thromb Haemost. 2006 Aug;96(2):119-25
references: 16894452
references: Arthritis Rheum. 1993 May;36(5):682-4
references: 8489547
references: Arthritis Rheum. 1982 Nov;25(11):1271-7
references: 7138600
references: Am J Hematol. 1993 Sep;44(1):70-2
references: 8342569
references: Nat Clin Pract Nephrol. 2006 Apr;2(4):221-30
references: 16932428
references: Arch Intern Med. 1996 Jun 24;156(12):1337-44
references: 8651844