title: Occupational risk factors for hip osteoarthritis are associated with early hip structural abnormalities: a 3.0 T magnetic resonance imaging study of community-based adults.
abstract: BACKGROUND
  Occupational exposure to heavy lifting and stair climbing are associated with radiographic hip osteoarthritis (OA). This study examined whether these activities are associated with early structural hip joint changes in a community-based population.
  
  
  METHODS
  In total, 198 community-based people with no history of hip disease, including OA, had 3.0 T-magnetic resonance imaging (MRI) to assess hip cartilage volume, defects and bone marrow lesions (BMLs). Recall of occupational exposure to heavy lifting and stair climbing aged 18 to 30 years and in the previous 10 years were collected. A persistence score was defined as exposure at neither time point (0), at one time point (1) or at both time points (2).
  
  
  RESULTS
  Exposure to heavy lifting when aged 18 to 30 years was associated with BMLs of the central superolateral femoroacetabular region (odds ratio (OR) 3.9, 95% confidence interval (CI) 1.6 to 9.8, P<0.01), with persistence score associated with cartilage defects in the central superolateral region of the femoral head (OR 1.6, 95% CI 1.0 to 2.5, P=0.04). Exposure to stair climbing aged 18 to 30 years and persistence score were associated with an increased risk of cartilage defects in the central superolateral femoral head and BMLs in the central superolateral and posterior femoroacetabular regions (OR range 2.1 to 3.2, all P≤0.03).
  
  
  CONCLUSIONS
  Occupational exposure to heavy lifting and stair climbing are associated with hip structural abnormalities. If confirmed by longitudinal data, such associations may explain how occupational activities affect the hip joint and may identify new targets for the prevention of hip OA.
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.|Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
authors: Andrew J
authors: AJ
authors: Teichtahl
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. sesmi8@student.monash.edu.au.
authors: Sam
authors: S
authors: Smith
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. yuanyuan.wang@monash.edu.
authors: Yuanyuan
authors: Y
authors: Wang
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. anita.wluka@monash.edu.
authors: Anita E
authors: AE
authors: Wluka
authors: MRI Department, Healthcare Imaging Services, Epworth Hospital, 89 Bridge Road, Richmond, VIC, 3121, Australia. richard.osullivan@monash.edu.|Department of Medicine, Central Clinical School, Monash University, 55 Commercial Road, Melbourne, VIC, 3004, Australia. richard.osullivan@monash.edu.
authors: Richard
authors: R
authors: O'Sullivan
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.|Cancer Epidemiology Centre, Cancer Council Victoria, 89 Bridge Road, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, VIC, 3053, Australia. graham.giles@cancervic.org.au.
authors: Graham G
authors: GG
authors: Giles
authors: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Road, Melbourne, VIC, 3004, Australia. Flavia.cicuttini@monash.edu.
authors: Flavia M
authors: FM
authors: Cicuttini
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005684:Gait / Q000502:physiology; D025981:Hip Injuries / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D017770:Lifting / Q000009:adverse effects; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D015207:Osteoarthritis, Hip / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors
references: IARC Sci Publ. 2002;156:69-70
references: 12484128
references: Am J Epidemiol. 2000 Nov 1;152(9):855-62
references: 11085397
references: Ergonomics. 1985 Feb;28(2):429-40
references: 3996385
references: Scand J Work Environ Health. 1991 Apr;17(2):104-9
references: 2047812
references: Scand J Work Environ Health. 1992 Feb;18(1):59-63
references: 1553513
references: Ann Rheum Dis. 1997 May;56(5):293-8
references: 9175929
references: Am J Epidemiol. 1998 Mar 15;147(6):523-8
references: 9521178
references: Arthritis Res Ther. 2014;16(5):466
references: 25304036
references: J Clin Epidemiol. 1999 Jul;52(7):643-51
references: 10391658
references: Arthritis Rheum. 2005 Apr;52(4):1069-76
references: 15818695
references: Occup Environ Med. 2008 Jan;65(1):6-19
references: 17634246
references: Arthritis Rheum. 2008 Oct;58(10):3172-82
references: 18821698
references: Osteoarthritis Cartilage. 2011 Aug;19(8):946-62
references: 21550411
references: Osteoarthritis Cartilage. 2013 Nov;21(11):1685-92
references: 23948977
references: J Rheumatol. 2000 Feb;27(2):434-40
references: 10685811
references: Clin Rheumatol. 2014 Mar;33(3):369-76
references: 24196987
references: Twin Res. 2003 Apr;6(2):147-51
references: 12724001