title: Tadalafil therapy and severe chronic foot wound resolution.
abstract: We report an unanticipated medication effect resulting in near-complete wound healing in a patient after beginning tadalafil therapy of 20 mg thrice daily. This patient was treated for 50 years with state-of-the art acute and then chronic wound interventions after a traumatic farm machinery accident which resulted in a devascularised foot wound. This infection was both life- and limb-threatening. The patient had undergone multiple vascular and plastic surgeries and antimicrobial therapies in addition to hospitalisations for sepsis. Limb amputation was being considered, when his urologist placed him on daily phosphodiesterase-5 inhibitor therapy, prior to unrelated urologic surgery. Remarkably, his foot wound underwent near-complete resolution and has been stable for 2 years.
authors: Department of Internal Medicine, Albany Medical College, Albany, NY, USA.
authors: Claire
authors: C
authors: Davenport
authors: Department of PM&R, Albany Medical College, Albany, NY, USA.
authors: Andrew
authors: A
authors: Dubin
mesh_terms: D000328:Adult; D002908:Chronic Disease; D018409:Foot Injuries / Q000150:complications / Q000473:pathology / Q000628:therapy*; D016523:Foot Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D000068581:Tadalafil / Q000627:therapeutic use*; D013997:Time Factors; D055815:Young Adult
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil
keywords: Chronic wound healing; Phosphodiesterase-5 inhibitor therapy
references: Proc Natl Acad Sci U S A. 1977 Oct;74(10):4360-4
references: 22077
references: Wound Repair Regen. 2009 Nov-Dec;17(6):763-71
references: 19903300
references: J Rheumatol. 2005 Dec;32(12):2440-2
references: 16331780
references: Science. 2001 Oct 5;294(5540):13
references: 11588222
references: Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1395-404
references: 20833962
references: J Clin Invest. 1986 Jul;78(1):1-5
references: 2873150
references: J Osaka Univ Dent Sch. 1986 Dec;26:187-92
references: 3470481
references: Nursing. 2004 Nov;34 Suppl Travel:8-13; quiz 13-4
references: 15744187
references: Scand J Plast Reconstr Surg Hand Surg. 2005;39(4):204-8
references: 16208781
references: Br J Plast Surg. 2004 Dec;57(8):769-72
references: 15544775
references: Pharmacol Rev. 2000 Jun;52(2):237-68
references: 10835101
references: Microcirculation. 2003 Jan;10(1):63-81
references: 12610664
references: Eur J Surg. 2000 Jul;166(7):530-4
references: 10965830
references: Ann Plast Surg. 2005 Sep;55(3):292-6
references: 16106170
references: Scand Cardiovasc J Suppl. 2013 Feb;47(1):58-64
references: 22994795
references: Cochrane Database Syst Rev. 2013 Sep 06;(9):CD004439
references: 24014191
references: Surg Forum. 1976;27(62):18-20
references: 1019847
references: Am J Surg. 2004 May;187(5A):65S-70S
references: 15147994
references: Rheumatology (Oxford). 2010 Dec;49(12):2420-8
references: 20837499
references: Ann Rheum Dis. 2005 Sep;64(9):1387
references: 16100356
references: Lupus. 2003;12(2):133-5
references: 12630758
references: Nature. 1987 Jun 11-17;327(6122):524-6
references: 3495737
references: Arch Surg. 1997 Sep;132(9):991-6
references: 9301612
references: Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E922-33
references: 23512808
references: J Biol Chem. 1996 Sep 6;271(36):21933-8
references: 8702997
references: Plast Reconstr Surg. 2006 Jun;117(7 Suppl):35S-41S
references: 16799373
references: New Horiz. 1996 May;4(2):179-83
references: 8774794
references: Laryngoscope. 2006 Apr;116(4):522-8
references: 16585853
references: Free Radic Res Commun. 1992;16(3):137-57
references: 1601328
references: Int Wound J. 2015 Oct;12(5):501-9
references: 24028468
references: N Engl J Med. 1978 Mar 23;298(12):659-68
references: 24176
references: Int Wound J. 2015 Feb;12(1):111-7
references: 23731453
references: Aesthetic Plast Surg. 2008 Jul;32(4):624-31
references: 18443849
references: Nurs Econ. 1992 Sep-Oct;10(5):353-9
references: 1465158
references: Cutis. 2014 Jan;93(1):E13-6
references: 24505591