title: Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats.
abstract: We investigated the protective effects of pine bark extract (pycnogenol®, PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1) vehicle control, (2) cisplatin (7.5 mg/kg), (3) cisplatin & PYC 10 (10 mg/kg/day), and (4) cisplatin & PYC 20 (20 mg/kg/day). A single intraperitoneal injection of cisplatin induced hepatotoxicity, as evidenced by an increase in serum aminotransferase and histopathological alterations, including degeneration/necrosis of hepatocytes, vacuolation, and sinusoidal dilation. In addition, an increase in the malondialdehyde (MDA) concentration and a decrease in the reduced glutathione (GSH) content and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities were observed in the cisplatin-treated rat hepatic tissues. In contrast, PYC treatment effectively prevented cisplatin-induced hepatotoxicity, including the elevation of aminotransferase and histopathological lesions, in a dosedependent manner. Moreover, PYC treatment also induced antioxidant activity by decreasing MDA level and increasing GSH content and SOD and GST activities in liver tissues. These results indicate that PYC has a protective effect against acute hepatotoxicity induced by cisplatin in rats, and that the protective effects of PYC may be due to inhibiting lipid peroxidation and increasing antioxidant activity.
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Je-Won
authors: JW
authors: Ko
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: In-Chul
authors: IC
authors: Lee
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Sung-Hyuk
authors: SH
authors: Park
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Changjong
authors: C
authors: Moon
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Seong-Soo
authors: SS
authors: Kang
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Sung-Ho
authors: SH
authors: Kim
authors: College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.
authors: Jong-Choon
authors: JC
authors: Kim
keywords: Cisplatin; hepatotoxicity; oxidative stress; pine bark extract; protective effects
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