title: Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects.
abstract: 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine by investigating. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA in 16 healthy subjects were investigated using a double-blind, placebo-controlled, crossover design. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. These results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA but do not support a modulatory role for dopamine in the mood effects of MDMA. These results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion and enhanced mood effects but also result in lower cardiac stimulation.
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Yasmin
authors: Y
authors: Schmid
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Anna
authors: A
authors: Rickli
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Antonia
authors: A
authors: Schaffner
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Urs
authors: U
authors: Duthaler
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Eric
authors: E
authors: Grouzmann
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.).
authors: Cédric M
authors: CM
authors: Hysek
authors: Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland (Y.S., A.R., A.S., U.D., C.M.H., M.E.L.); and Biomedicine Service, University Hospital Lausanne, Lausanne, Switzerland (E.G.) matthias.liechti@usb.ch.
authors: Matthias E
authors: ME
authors: Liechti
mesh_terms: D000328:Adult; D016642:Bupropion / Q000493:pharmacokinetics / Q000494:pharmacology*; D018592:Cross-Over Studies; D004298:Dopamine / Q000097:blood; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D004311:Double-Blind Method; D004347:Drug Interactions; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000378:metabolism; D010121:Oxytocin / Q000097:blood; D011388:Prolactin / Q000097:blood; D011619:Psychotropic Drugs / Q000493:pharmacokinetics / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011619:Psychotropic Drugs; D016642:Bupropion; D010121:Oxytocin; D011388:Prolactin; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D004298:Dopamine; D006854:Hydrocortisone; D004837:Epinephrine