title: The effectiveness of sublingual or oral administration of misoprostol for cervical ripening before manual vacuum aspiration in first trimester termination of pregnancy: randomized controlled trial.
abstract: OBJECTIVE
  To compare the effectiveness of misoprostol sublingual and oral routes before manual vacuum aspiration (MVA) in first trimester termination of pregnancy.
  
  
  METHODS
  A double-blinded randomized controlled trial was conducted infirst trimester termination ofpregnancy cases. Eighty cases were recruited and divided into sublingual and oral groups. Both groups were randomized to receive 400 microg misoprostol two hours prior to MVA. Main outcomes were cervical dilatation, operative time, complications, side effects, pain scores, and patient satisfactions.
  
  
  RESULTS
  Sublingual group had significantly more cervical dilatation and shorter operative time than oral group (7.3 +/- 1.5 vs. 5.9 +/- 1.4 mm, p<0.001 and 5.2 +/- 3.3 vs. 7.3 +/- 4.6 min, p = 0.02, respectively). However there were similar side effects, pain scores, and patient satisfactions in two groups. The present study had no uterine perforation, cervical tear hemorrhage, or re-evacuation.
  
  
  CONCLUSIONS
  Sublingual misoprostol route was more effective for cervical priming prior to MVA in first trimester therapeutic abortion than oral route.
authors: Awassada
authors: A
authors: Punjyashthira
authors: Densak
authors: D
authors: Pongrojpaw
authors: Komsun
authors: K
authors: Suwannarurk
authors: Kornkarn
authors: K
authors: Bhamarapravatana
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D020070:Cervical Ripening; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage*; D017060:Patient Satisfaction; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016896:Treatment Outcome; D014619:Vacuum Curettage
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol