title: An intuitive thermal-induced surface zwitterionization for versatile, well-controlled haemocompatible organic and inorganic materials.
abstract: In this study, a facile and effective strategy is presented for the preparation of a series of zwitterionic poly(sulfobetaine methacrylate) (pSBMA)-grafted organic and inorganic biomaterials with well-controlled haemocompatibility via intuitive thermal-induced graft polymerization. The research focused on the effects of zwitterionic surface packing density on human blood compatibility by varying the SBMA monomer concentration on the silanized silicon wafer substrates. A 0.2 M SBMA monomer solution was found to not only produce Si wafer surfaces with ideal zwitterionic surface packing density and uniform, evenly distributed pSBMA grafting coverage but also yield optimal hydrophilicity and haemocompatibility. SBMA monomer concentrations lower and greater than 0.2 M yielded a zwitterionic surface with low grafting coverage. This study also demonstrated that the same, intuitive thermal-induced graft polymerization strategy could be applied to a variety of organic polymeric, inorganic ceramic and metal oxide biomaterials to improve haemocompatibility. Among the tested organic and inorganic materials, however, it was found that inorganic biomaterials demonstrated greater resistance to protein and platelet adhesions. It was hypothesized that the ozone treatment, which generated an abundance of hydroxide groups on inorganic substrate interfaces, might have given the inorganic biomaterials a more stable silanized layer yielding a preferable reaction state and resulted in sturdier and more durable pSBMA grafting.
authors: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan 320, Taiwan.
authors: Mei-Chan
authors: MC
authors: Sin
authors: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan 320, Taiwan.
authors: Pei-Tzu
authors: PT
authors: Lou
authors: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan 320, Taiwan.
authors: Chia-He
authors: CH
authors: Cho
authors: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors: Arunachalam
authors: A
authors: Chinnathambi
authors: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
authors: Sulaiman Ali
authors: SA
authors: Alharbi
authors: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan 320, Taiwan. Electronic address: ychang@cycu.edu.tw.
authors: Yung
authors: Y
authors: Chang
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007287:Inorganic Chemicals / Q000494:pharmacology*; D007477:Ions; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000494:pharmacology; D018625:Microscopy, Atomic Force; D009930:Organic Chemicals / Q000494:pharmacology*; D056951:Photoelectron Spectroscopy; D013499:Surface Properties; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D007287:Inorganic Chemicals; D007477:Ions; D008689:Methacrylates; D009930:Organic Chemicals; C521589:sulfobetaine methacrylate polymer; D005340:Fibrinogen
keywords: Haemocompatibility; Packing density; Thermal-induced surface zwitterionization; Versatility