title: The role of autophagy in vascular biology.
abstract: There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology and a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but important triggers that range from oxidized lipids to β-amyloid seem to stimulate autophagosome formation potently. In addition, emerging evidence links autophagy to a wide array of vascular processes ranging from angiogenesis to calcification of the vessel wall. Alterations in autophagic flux are also increasingly being implicated in disease processes that include both atherosclerosis and pulmonary hypertension. Finally, recent insights point toward an important role of autophagy in the paracrine regulation of vasoactive substances from the endothelium. Here, we review the progress in understanding how autophagy can contribute to vascular biology and the emerging strategies to target this process for therapeutic benefit.
authors: From the Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.N, T.F.); and Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (S.V.).
authors: Samuel C
authors: SC
authors: Nussenzweig
authors: From the Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.N, T.F.); and Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (S.V.).
authors: Subodh
authors: S
authors: Verma
authors: From the Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.N, T.F.); and Division of Cardiac Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (S.V.). finkelt@nih.gov.
authors: Toren
authors: T
authors: Finkel
mesh_terms: D000375:Aging; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D004730:Endothelium, Vascular / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D008054:Lipid Peroxides
keywords: aging; angiogenesis effect; autophagy; endothelial cells
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