title: HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population.
abstract: Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. Human leukocyte antigen (HLA) alleles play an important role in the development of TA. Sequence specific primer-polymerase chain reaction was used to detect 10 alleles of the HLA-DQA1 gene and 13 alleles of the HLA-DQB1, -DRB1 gene. A significant increase in the frequencies of DRB1(∗)07 (Pc<0.01, OR=3.44, CI: 2.15-5.52) was observed among TA patients compared with the control group. The significantly increased frequencies of the haplotype DQA1(∗)03:01-DQB1(∗)03:01-DRB1(∗)07 (Corrected P-values<0.01) were observed in TA patients. But in the analysis of clinical manifestations, there are no significant associations with the HLA-DRB1(∗)07 allele.
authors: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China.
authors: Naqiang
authors: N
authors: Lv
authors: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China.
authors: Zhiguang
authors: Z
authors: Wang
authors: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China.
authors: Aimin
authors: A
authors: Dang
authors: National Laboratory of Medical Molecular Biology and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, People's Republic of China.
authors: Xilin
authors: X
authors: Zhu
authors: National Laboratory of Medical Molecular Biology and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, People's Republic of China.
authors: Ying
authors: Y
authors: Liu
authors: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China.
authors: Deyu
authors: D
authors: Zheng
authors: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China.
authors: Guozhang
authors: G
authors: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059848:HLA-DQ alpha-Chains / Q000235:genetics*; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013625:Takayasu Arteritis / Q000235:genetics*; D055815:Young Adult
chemical_list: D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains
keywords: Chinese Han population; DQA1; DQB1; DRB1; Takayasu arteritis