title: HDL-mimetic PLGA nanoparticle to target atherosclerosis plaque macrophages.
abstract: High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and the phospholipid corona make the HDL platform an attractive nanocarrier. To realize controlled release properties, we developed a hybrid polymer/HDL nanoparticle composed of a lipid/apolipoprotein coating that encapsulates a poly(lactic-co-glycolic acid) (PLGA) core. This novel HDL-like nanoparticle (PLGA-HDL) displayed natural HDL characteristics, including preferential uptake by macrophages and a good cholesterol efflux capacity, combined with a typical PLGA nanoparticle slow release profile. In vivo studies carried out with an ApoE knockout mouse model of atherosclerosis showed clear accumulation of PLGA-HDL nanoparticles in atherosclerotic plaques, which colocalized with plaque macrophages. This biomimetic platform integrates the targeting capacity of HDL biomimetic nanoparticles with the characteristic versatility of PLGA-based nanocarriers.
authors: Brenda L
authors: BL
authors: Sanchez-Gaytan
authors: Francois
authors: F
authors: Fay
authors: ‡Department of Vascular Medicine, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands.
authors: Mark E
authors: ME
authors: Lobatto
authors: Jun
authors: J
authors: Tang
authors: ∥Departments of Medicine (Cardiology) and Cell Biology, NYU School of Medicine, New York, New York 10016, United States.
authors: Mireille
authors: M
authors: Ouimet
authors: ⊥The George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
authors: YongTae
authors: Y
authors: Kim
authors: Susanne E M
authors: SE
authors: van der Staay
authors: Sarian M
authors: SM
authors: van Rijs
authors: Bram
authors: B
authors: Priem
authors: #Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
authors: Liangfang
authors: L
authors: Zhang
authors: ∥Departments of Medicine (Cardiology) and Cell Biology, NYU School of Medicine, New York, New York 10016, United States.
authors: Edward A
authors: EA
authors: Fisher
authors: ∥Departments of Medicine (Cardiology) and Cell Biology, NYU School of Medicine, New York, New York 10016, United States.
authors: Kathryn J
authors: KJ
authors: Moore
authors: ○David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
authors: Robert
authors: R
authors: Langer
authors: Zahi A
authors: ZA
authors: Fayad
authors: ‡Department of Vascular Medicine, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands.
authors: Willem J M
authors: WJ
authors: Mulder
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000379:methods; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D008075:Lipoproteins, HDL; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
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