title: Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses.
abstract: In an observational study of 582 patients with laboratory-confirmed influenza virus infections and their household contacts, we found that the initiation of oseltamivir within 24 hours was associated with shorter duration of self-reported illness symptoms (56% reduction in duration; 95% confidence interval, 41%-67%). However, we did not find any association of oseltamivir treatment with duration of viral shedding by polymerase chain reaction or with the risk of household transmission.
authors: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
authors: Doug H
authors: DH
authors: Cheung
authors: School of Public Health.
authors: Tim K
authors: TK
authors: Tsang
authors: School of Public Health.
authors: Vicky J
authors: VJ
authors: Fang
authors: School of Public Health.
authors: Jiajing
authors: J
authors: Xu
authors: Department of Microbiology.
authors: Kwok-Hung
authors: KH
authors: Chan
authors: School of Public Health.
authors: Dennis K M
authors: DK
authors: Ip
authors: School of Public Health Centre of Influenza Research, Li Ka Shing Faculty of Medicine, University of Hong Kong.
authors: Joseph Sriyal Malik
authors: JS
authors: Peiris
authors: School of Public Health.
authors: Gabriel M
authors: GM
authors: Leung
authors: School of Public Health.
authors: Benjamin J
authors: BJ
authors: Cowling
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000188:drug therapy* / Q000635:transmission* / Q000821:virology; D008297:Male; D009975:Orthomyxoviridae / Q000187:drug effects / Q000502:physiology*; D053139:Oseltamivir / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D017201:Virus Shedding / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir
keywords: acute respiratory illness; influenza; oseltamivir
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