title: Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration.
abstract: Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Renan O
authors: RO
authors: Silva
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Samara R B
authors: SR
authors: Damasceno
authors: Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.
authors: Irismara S
authors: IS
authors: Silva
authors: Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.
authors: Valdelânia G
authors: VG
authors: Silva
authors: Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.
authors: Camila F C
authors: CF
authors: Brito
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Antônio Éder A
authors: AÉ
authors: Teixeira
authors: Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil.
authors: Geandra B L
authors: GB
authors: Nunes
authors: Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE, Brazil.
authors: Celso A
authors: CA
authors: Camara
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil.
authors: José Maria B
authors: JM
authors: Filho
authors: Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI, Brazil.
authors: Stanley J C
authors: SJ
authors: Gutierrez
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Ronaldo A
authors: RA
authors: Ribeiro
authors: Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Marcellus H L P
authors: MH
authors: Souza
authors: Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.
authors: André L R
authors: AL
authors: Barbosa
authors: Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil.
authors: Rivelilson M
authors: RM
authors: Freitas
authors: Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil. Electronic address: jandvenes@ufpi.edu.br.
authors: Jand Venes R
authors: JV
authors: Medeiros
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use; D001549:Benzamides / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan / Q000009:adverse effects* / Q000276:immunology; D002448:Cell Adhesion / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005121:Extremities / Q000473:pathology; D007154:Immune System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D019770:Lauraceae / Q000737:chemistry; D007960:Leukocyte Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D036904:Leukocyte Rolling / Q000187:drug effects; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000276:immunology; D010627:Phenethylamines / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001549:Benzamides; D016207:Cytokines; C000596368:N-phenethylbenzamide; D010627:Phenethylamines; D002351:Carrageenan; D009195:Peroxidase
keywords: Inflammation; Neutrophil; Oxidative stress; Riparin