title: The oxytocin receptor gene and social perception.
abstract: Social perception is an important prerequisite for successful social interaction, because it helps to gain information about behaviors, thoughts, and feelings of interaction partners. Previous pharmacological studies have emphasized the relevance of the oxytocin system for social perception abilities, while knowledge on genetic contributions is still scarce. In the endeavor to fill this gap in the literature, the current study searches for associations between participants' social perception abilities as measured by the interpersonal perception task (IPT) and the rs2268498 polymorphism on the OXTR-gene, which has repeatedly been linked to processes relevant to social functioning. N = 105 healthy participants were experimentally tested with the IPT and genotyped for the rs2268498 polymorphism. T-allele carriers (TT and TC genotypes) exhibited significantly better performance in the IPT than carriers of the CC-genotype. This difference was also significant for the subscales measuring the strength of social bonding (kinship and intimacy). As in previous studies, T-allele carriers exhibited better performance in measures of social processing indicating that the rs2268498 polymorphism is an important candidate for understanding the genetic basis of social functioning.
authors: a Department of Psychology , University of Bonn , Bonn , Germany.
authors: Martin
authors: M
authors: Melchers
authors: Christian
authors: C
authors: Montag
authors: Andrea
authors: A
authors: Felten
authors: Martin
authors: M
authors: Reuter
mesh_terms: D000293:Adolescent; D005260:Female; D005838:Genotype; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018045:Receptors, Oxytocin / Q000235:genetics*; D012938:Social Perception; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: C569600:OXTR protein, human; D018045:Receptors, Oxytocin
keywords: Interpersonal perception task; OXTR; Oxytocin; Social perception; rs2268498