title: Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma.
abstract: Small cell carcinoma (SmCC) of the prostate is a rare and aggressive histologic subtype of the prostate cancer. It can sometimes mimic acinar adenocarcinoma with a high Gleason score (GS). A previous study showed that immunohistochemical staining for CD44 could help in the differential diagnosis of these 2 entities. In this study, we used 2 tissue microarrays including 63 cases of prostate cancer (18 pure SmCC, 37 pure acinar adenocarcinoma, and 8 mixed acinar adenocarcinoma and SmCC) to validate the value of CD44. When analyzed as a continuous variable, CD44 positivity was significantly higher in acinar adenocarcinoma with GS 8 than GS 9 to 10 (P = .027). However, the difference of CD44 expression between SmCC and acinar adenocarcinoma was insignificant. The current study fails to confirm the value of CD44 in differential diagnosis between prostatic SmCC and acinar adenocarcinoma.
authors: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan 100.
authors: Chung-Chieh
authors: CC
authors: Wang
authors: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231.
authors: Angelo M
authors: AM
authors: De Marzo
authors: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231.
authors: Tamara L
authors: TL
authors: Lotan
authors: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231; Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD, United States 21231. Electronic address: jepstein@jhmi.edu.
authors: Jonathan I
authors: JI
authors: Epstein
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D018267:Carcinoma, Acinar Cell / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D018960:Hyaluronan Receptors
keywords: Acinar adenocarcinoma; CD44; Immunohistochemistry; Prostate cancer; Small cell carcinoma