title: Cartilage tissue engineering: recent advances and perspectives from gene regulation/therapy.
abstract: Diseases in articular cartilages affect millions of people. Despite the relatively simple biochemical and cellular composition of articular cartilages, the self-repair ability of cartilage is limited. Successful cartilage tissue engineering requires intricately coordinated interactions between matrerials, cells, biological factors, and phycial/mechanical factors, and still faces a multitude of challenges. This article presents an overview of the cartilage biology, current treatments, recent advances in the materials, biological factors, and cells used in cartilage tissue engineering/regeneration, with strong emphasis on the perspectives of gene regulation (e.g., microRNA) and gene therapy.
authors: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 300.
authors: Kuei-Chang
authors: KC
authors: Li
authors: Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 300.
authors: Yu-Chen
authors: YC
authors: Hu
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000502:physiology*; D053263:Gene Regulatory Networks / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D012038:Regeneration / Q000235:genetics*; D023822:Tissue Engineering / Q000379:methods*
keywords: cartilage; cell therapy; gene therapy; osteoarthritis; regenerative medicine; tissue engineering