title: Prognostic Value of Expression of Cyclin E in Gastrointestinal Cancer: A Systematic Review and Meta-Analysis.
abstract: Cyclin E is a critical regulator in cell cycle and promotes the initiation of DNA replication and centrosome duplication in late G1. The overexpression of cyclin E is common in cancers of the digestive system. However, whether cyclin E represents a prognostic biomarker in gastrointestinal cancer remains controversial. We reviewed the published literatures to clarify the association between cyclin E determined by immunohistochemistry (IHC) and survival in gastrointestinal cancer. Literatures were searched in PubMed and Cochrane Library published up to December 1, 2014. A total of 282 articles were initially identified, and 14 articles were included in this study. Meta-analysis was performed for 10 studies with a total of 1300 patients. Combined hazard risk (HR) and corresponding 95% confidence interval (CI) were calculated by random-effect model due to the heterogeneity. The quality of included studies was assessed by the Newcastle-Ottawa Scale and the Methodological Index for Non-Randomized Studies (MINORS). We found that high level of cyclin E was a predicator of poor prognosis among patients with gastrointestinal cancer (HR = 1.67, 95% CI = 1.06-2.63, P = .028). In summary, overexpression of cyclin E is associated with poor prognosis in gastrointestinal cancer and expression of cyclin E determined by IHC might be a prognostic marker for gastrointestinal cancer in clinical practice.
authors: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors: Lanshan
authors: L
authors: Huang
authors: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors: Fanghui
authors: F
authors: Ren
authors: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors: Ruixue
authors: R
authors: Tang
authors: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors: Zhenbo
authors: Z
authors: Feng
authors: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China chen_gang_triones@163.com.
authors: Gang
authors: G
authors: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D019927:Cyclin E / Q000378:metabolism*; D005770:Gastrointestinal Neoplasms / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019927:Cyclin E
keywords: colorectal cancer; cyclin E; gastric cancer; meta-analysis; prognosis