title: A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia.
authors: Department of Medicine (Oncology), Division of Hemato-Oncology; the Department of Developmental and Molecular Biology; the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research; and the Albert Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York, USA.
authors: Amit
authors: A
authors: Verma
authors: Department of Cell Biology; the Department of Medicine (Oncology), Division of Hemato-Oncology; the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research; and the Albert Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York, USA.
authors: Ulrich
authors: U
authors: Steidl
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D019253:Proto-Oncogene Proteins c-bcl-2; D013449:Sulfonamides; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; C579720:venetoclax
references: Science. 2013 May 3;340(6132):626-30
references: 23558169
references: Eur J Haematol. 2013 May;90(5):385-96
references: 23444869
references: Nat Med. 2013 Feb;19(2):202-8
references: 23291630
references: Science. 2013 May 3;340(6132):622-6
references: 23558173
references: Cancer Cell. 2010 Mar 16;17 (3):225-34
references: 20171147
references: Science. 2008 Sep 26;321(5897):1807-12
references: 18772396
references: Biochim Biophys Acta. 2002 Jan 2;1586(1):81-91
references: 11781152
references: Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2548-53
references: 24550281
references: Nature. 2009 Dec 10;462(7274):739-44
references: 19935646
references: N Engl J Med. 2009 Sep 10;361(11):1058-66
references: 19657110
references: Cancer Cell. 2010 Dec 14;18(6):553-67
references: 21130701
references: Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14087-91
references: 22891333
references: Stem Cells Transl Med. 2013 Feb;2(2):143-50
references: 23349328
references: Mol Genet Metab. 2005 Sep-Oct;86(1-2):188-99
references: 15963747
references: Nat Med. 2015 Feb;21(2):178-84
references: 25599133