title: Botulinum toxin: An effective treatment for prosthesis-related hyperhidrosis in patients with traumatic amputations.
abstract: Hyperhidrosis-related to prosthesis use in patients who have suffered a traumatic limb amputation presents itself as a barrier to comfort, prosthesis use and overall quality of life. This review intends to encourage dermatologists to consider the use of botulinum toxin A or B for the treatment of hyperhidrosis in the residual limb and may serve as a stimulus for a modern, in-depth, and more comprehensive study. A review of the literature was conducted using the PubMed database, focusing on hyperhidrosis treatment after traumatic limb amputation. Articles discussing hyperhidrosis treatment for amputations secondary to chronic medical conditions were excluded. Seven case studies published over the last 12 years have demonstrated positive outcomes of this treatment strategy. Overall, there is little data examining this topic and current publications focus primarily on small case series. A larger, double-blind, placebo-controlled study would likely benefit veterans, service members, and civilians.
authors: Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
authors: Amanda
authors: A
authors: Lezanski-Gujda
authors: Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
authors: Jonathan L
authors: JL
authors: Bingham
authors: Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
authors: Nicholas F
authors: NF
authors: Logemann
keywords: Amputation; botulinum toxin; hyperhidrosis; prosthesis comfort; trauma-related amputation
references: Dermatol Surg. 2005 Mar;31(3):263-70
references: 15841624
references: Clin Neuropharmacol. 2010 Sep-Oct;33(5):243-7
references: 20852412
references: Dermatol Surg. 2007 Nov;33(11):1401-2
references: 17958602
references: Pain Med. 2009 Mar;10(2):300-3
references: 19207237
references: J Cutan Aesthet Surg. 2008 Jan;1(1):3-6
references: 20300330
references: Arch Dermatol. 2010 Nov;146(11):1314-5
references: 21079082
references: Am J Phys Med Rehabil. 2001 Aug;80(8):563-71
references: 11475475
references: Eur Neurol. 2003;49(1):34-8
references: 12464716
references: Schmerz. 2012 Apr;26(2):176-84
references: 22527647
references: Am J Phys Med Rehabil. 2011 Apr;90(4):321-9
references: 21765248
references: Am J Phys Med Rehabil. 2004 May;83(5):396-9
references: 15100632
references: Acta Derm Venereol. 2000 May;80(3):226-7
references: 10954228
references: J Control Release. 2013 Jan 28;165(2):146-52
references: 23178949
references: Arch Phys Med Rehabil. 2008 Jul;89(7):1407-9
references: 18586144
references: J Rehabil Res Dev. 2010;47(4):361-71
references: 20803404
references: Am J Ther. 2012 Jul;19(4):281-6
references: 22481607
references: J Rehabil Med. 2004 Sep;36(5):238-9
references: 15626165