title: Canada's longest experience with extracorporeal membrane oxygenation as a bridge to lung transplantation: a case report.
abstract: BACKGROUND
  Extracorporeal membrane oxygenation (ECMO) is a method of enabling gas exchange through an external membrane used to treat respiratory failure in critically ill patients. ECMO as a bridge to lung transplantation has been investigated as a potential method of reducing lung transplantation waitlist mortality. Herein we describe a case of ECMO as a bridge-to-lung transplantation for the duration of 35 days, which is the longest documented length of ECMO support before successful transplantation in Canada.
  
  
  METHODS
  The prospective recipient was a 28-year-old female suffering from stage 4 pulmonary sarcoidosis. Given an acute exacerbation of her chronic respiratory failure, ECMO had to be initiated. She remained on ECMO for 35 days until a suitable set of donor lungs became available. The recipient had a prolonged course in hospital but was successfully discharged home where she continues to have good lung function. She remains alive and well at home 5 months post-transplantation and continues to improve and gain strength.
  
  
  CONCLUSIONS
  Our case provides hope that in the future we may be able to expand the population of recipients who may be candidates for lung transplantation. This case adds to the growing literature on the role of ECMO as a bridge-to-lung transplantation with the potential to reduce patient deaths while wait-listed for lung transplantation as well as increase the number of transplantations being performed.
authors: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors: S
authors: S
authors: Bozso
authors: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.
authors: S
authors: S
authors: Sidhu
authors: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada.
authors: M
authors: M
authors: Garg
authors: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada; Canadian National Transplant Research Program, Edmonton, Alberta, Canada.
authors: D H
authors: DH
authors: Freed
authors: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada; Alberta Transplant Institute, Edmonton, Alberta, Canada; Canadian National Transplant Research Program, Edmonton, Alberta, Canada. Electronic address: jayan@ualberta.ca.
authors: J
authors: J
authors: Nagendran
mesh_terms: D000328:Adult; D002170:Canada; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome