title: Survey on childhood solid malignant tumors in cases admitted to mofid pediatric hospital from 1996-2010: a single-center study.
abstract: BACKGROUND
  As children comprise a considerable proportion of our population, the importance of local epidemiologic research and geographic and racial differences can't be disputed on childhood malignancies.
  
  
  METHODS
  In this descriptive retrospective study, we extensively reviewed the medical records of patients younger than 15 years of age, diagnosed with solid malignant tumors, from 1996 to 2010, using the last version of International Classification of Childhood Cancers.
  
  
  RESULTS
  In our study the order of incidence of solid malignancies was relatively similar to the other national studies, with lymphomas and Central Nervous System (CNS) tumors as the most common, followed by Sympathetic Nervous System (SNS) tumors, soft tissue sarcomas and renal tumors. The peak age of diagnosis was between 1 and 4 years old. In our study, the overall male to female ratio was 1.38, with a trend towards male dominance in the older age groups. We also observed a disturbing trend of childhood solid malignancies. The total number of cases almost doubled from 2009(54(6.9%)) to 2010(96(12.2%)) .This trend was particularly detected in CNS and SNS tumors. Further analysis showed that malignant CNS tumors had played a more pronounced role in this change.
  
  
  CONCLUSIONS
  Changes in trends of some tumor categories have illustrated a desperate need to further research in regional and national levels. Also the gathered data can be used to make more accurate programs for a better control of cancer and to help policymakers to allocate more evidence-based resource for hospitals.
authors: Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Farzaneh
authors: F
authors: Jadali
authors: Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Hosein
authors: H
authors: Aghayan Golkashani
authors: School of Public Health, Faculty of Health Sciences, Simone Fraser University, Vancouver, British Colombia.
authors: Golareh
authors: G
authors: Habibi
authors: Dept. of Pediatric Surgery, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mohsen
authors: M
authors: Rouzrokh
authors: Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Fatemeh
authors: F
authors: Abdollah Gorji
authors: Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Fahimeh
authors: F
authors: Dini
authors: Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Malihe
authors: M
authors: Khodami
authors: Dept. of Pediatric Pathology, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Yalda
authors: Y
authors: Nilipour
authors: Dept. of Pediatric Surgery, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Ahmad
authors: A
authors: Khaleghnejad Tabari
authors: Dept. of Pediatric Surgery, Medical Research and Development Center of Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Naser
authors: N
authors: Sadeghian
keywords: Child; Epidemiology; Infant; Neoplasm; Pediatric hospital
references: Eur J Cancer. 1993;29A(7):1008-12
references: 8499132
references: Med Pediatr Oncol. 2002 Sep;39(3):149-55
references: 12210442
references: Oncogene. 2004 Aug 23;23(38):6429-44
references: 15322515
references: Eur J Cancer. 2004 Jun;40(9):1351-60
references: 15177495
references: Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):364-9
references: 16236001
references: Eur J Cancer. 2006 Sep;42(13):1961-71
references: 16919764
references: Cancer. 2008 Feb 1;112(3):461-72
references: 18072274
references: Ann Oncol. 2010 May;21(5):1106-11
references: 19858086
references: Cancer. 2008 Jan 15;112(2):416-32
references: 18074355
references: Eur J Cancer. 2006 Sep;42(13):1952-60
references: 16919763
references: J Natl Cancer Inst. 2004 Dec 15;96(24):1809
references: 15601635
references: J Pediatr Hematol Oncol. 2010 Jul;32(5):376-82
references: 20588194
references: Ann N Y Acad Sci. 2006 Sep;1076:29-53
references: 17119192
references: Lancet. 2005 Feb 26-Mar 4;365(9461):753
references: 15733714
references: Cancer. 2000 Mar 15;88(6):1492-3
references: 10717635
references: Int J Cancer. 2003 Jul 1;105(4):552-7
references: 12712449
references: Pediatr Blood Cancer. 2009 Jul;53(1):1-2
references: 19326404
references: Br J Cancer. 2010 Feb 2;102(3):620-6
references: 20051948