title: Antiedema effects of proanthocyanidin on experimental traumatic brain edema.
abstract: OBJECTIVE
  Brain edema developing due to central nervous system trauma is still a significant reason of mortality and morbidity. There is still no definite approach for the medical treatment of brain edema despite many clinical and laboratory studies in recent years. We therefore investigated the effect of proanthocyanidin, an antioxidant agent, on brain edema in this study.
  
  
  METHODS
  A total of 30 rats were used and divided into three as the control, trauma and treated trauma groups. Subjects were sacrificed after 72 hours. The brain tissue-water ratio was evaluated and biochemical analysis of brain tissue performed.
  
  
  RESULTS
  The difference between the treated trauma and control groups was statistically significant while the trauma and control groups were relatively similar. Rats that had undergone trauma and received proanthocyanidin treatment were statistically significant and different from the trauma group rats regarding the biochemical analysis results, brain tissue water ratio, and the cold damage enzymatic antioxidant defense system of cortical neural tissue.
  
  
  CONCLUSIONS
  We believe that proanthocyanidin, an antioxidant substance, can be an effective treatment for brain edema.
authors: Ankara Training and Research Hospital, Department of Neurosurgery, Ankara, Turkey.
authors: Yavuz
authors: Y
authors: Erdem
authors: Ayhan
authors: A
authors: Tekiner
authors: Yavuz Selim
authors: YS
authors: Erkoc
authors: Muhammet Bahadır
authors: MB
authors: Yilmaz
authors: Haydar
authors: H
authors: Celik
authors: Ali Erdem
authors: AE
authors: Yildirim
authors: Ayse Selda
authors: AS
authors: Tekiner
authors: Mehmet Akif
authors: MA
authors: Bayar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D001929:Brain Edema / Q000517:prevention & control*; D001930:Brain Injuries; D008297:Male; D023421:Models, Animal; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats
chemical_list: D000975:Antioxidants; D044945:Proanthocyanidins; C013221:proanthocyanidin