title: Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system.
abstract: We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.
authors: Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611 ; Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208.
authors: Job
authors: J
authors: Boekhoven
authors: Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611.
authors: R Helen
authors: RH
authors: Zha
authors: Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611 ; Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208.
authors: Faifan
authors: F
authors: Tantakitti
authors: Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208.
authors: Ellen
authors: E
authors: Zhuang
authors: Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208.
authors: Roya
authors: R
authors: Zandi
authors: Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611.
authors: Christina J
authors: CJ
authors: Newcomb
authors: Simpson Querrey Institute for BioNanotechnology, 303 E. Superior Ave, Chicago, IL 60611 ; Department of Chemistry, Department of Biomedical Engineering and Department of Chemical Engineering, Northwestern University, Tech Building, 2145 Sheridan Road, Evanston, IL 60208 ; Department of Materials Science and Engineering, Northwestern University, Cook Hall, 2220 Campus Drive, Evanston, IL 60208 ; Department of Medicine, Feinberg School of Medicine, Galter Pavilion, 251 E. Huron St., Chicago, IL 60611.
authors: Samuel I
authors: SI
authors: Stupp
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