title: In vivo and in vitro IL-18 production during uveitis associated with Behçet disease: effect of glucocorticoid therapy.
abstract: Uveitis represents one of the major diagnostic criteria in Behçet's disease. It is most prevalent in the countries of the Mediterranean area, including Algeria, and along the Silk Road. Clinical features include oral and genital ulcers, ocular and skin lesions, as well as central nervous system, joint, vascular, gastrointestinal, or pulmonary manifestations. Many studies have reported that Th1 immune responses are involved in the physiopathology. We have previously studied the production of IL-12 and IFN-γ, cytokine markers in the Th1 pathway involved in Behçet's disease. In our study, we investigate in vivo and in vitro IL-18 production in Algerian patients with Behçet's disease with ocular manifestations in various stages of the disease. We examined the effect of glucocorticoids on IL-18 production during the active stage of the disease. Our results suggest that IL-18 could be a good biomarker for monitoring disease activity and its regression, demonstrating the effectiveness of treatment on the underlying immunopathologic process.
authors: USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria. Electronic address: houdabelbi@yahoo.fr.
authors: H
authors: H
authors: Belguendouz
authors: USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
authors: D
authors: D
authors: Messaoudene
authors: USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
authors: K
authors: K
authors: Lahmar-Belguendouz
authors: USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
authors: Z
authors: Z
authors: Djeraba
authors: Clinique de médecine interne, CHU Mustapha Pacha, place du 1(er) Mai 1945, Sidi M'Hamed, 16000 Alger, Algeria.
authors: F
authors: F
authors: Otmani
authors: Clinique d'ophtalmologie, CHU Bab El Oued, boulevard Said Touati, 16000 Alger, Algeria.
authors: M
authors: M
authors: Terahi
authors: Clinique d'ophtalmologie, CHU Bab El Oued, boulevard Said Touati, 16000 Alger, Algeria.
authors: M
authors: M
authors: Tiar
authors: Clinique d'ophtalmologie, CHU Mustapha Pacha, Place du 1er Mai 1945, Sidi M'Hamed, 16000 Alger, Algeria.
authors: D
authors: D
authors: Hartani
authors: Service d'ophtalmologie, CHU Ibn Rochd, route de SeraidI, Annaba, Algeria.
authors: O S
authors: OS
authors: Lahlou-Boukoffa
authors: USTHB, LBCM, équipe "cytokines et NO synthases", FSB, université Bab-Ezzouar, PB 32, 16111 Alger, Algeria.
authors: C
authors: C
authors: Touil-Boukoffa
mesh_terms: D000328:Adult; D000462:Algeria; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D020551:Pulse Therapy, Drug; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology*; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology*; D014606:Uveitis, Anterior / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D015415:Biomarkers; D020382:Interleukin-18; D008775:Methylprednisolone
keywords: Behçet disease; Cytokines; Glucocorticoids; Glucocorticoïdes; IL-18; Maladie de Behçet; Th1; Uveitis; Uvéite