title: Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study.
abstract: Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of a FFQ-derived dietary inflammatory index (DII) to predict inflammation. Data from a Belgian cross-sectional study of 2524 generally healthy subjects (age 35-55 years) were used. The DII is a population-based, literature-derived dietary index that was developed to predict inflammation and inflammation-related chronic diseases. The DII was calculated from FFQ-derived dietary information and tested against inflammatory markers, namely C-reactive protein (CRP), IL-6, homocysteine and fibrinogen. Analyses were performed using multivariable logistic regression, adjusting for energy, age, sex, BMI, smoking status, education level, use of non-steroidal anti-inflammatory drugs, blood pressure, use of oral contraceptives, anti-hypertensive therapy, lipid-lowering drugs and physical activity. Multivariable analyses showed significant positive associations between the DII and the inflammatory markers IL-6 (>1·6 pg/ml) (OR 1·19, 95 % CI 1·04, 1·36) and homocysteine (>15 μmol/l) (OR 1·56, 95 % CI 1·25, 1·94). No significant associations were observed between the DII and the inflammatory markers CRP and fibrinogen. These results reinforce the fact that diet, as a whole, plays an important role in modifying inflammation.
authors: Cancer Prevention and Control Program, University of South Carolina,915 Greene Street, Suite 241,Columbia,SC29208,USA.
authors: Nitin
authors: N
authors: Shivappa
authors: Cancer Prevention and Control Program, University of South Carolina,915 Greene Street, Suite 241,Columbia,SC29208,USA.
authors: James R
authors: JR
authors: Hébert
authors: Department of Cardiovascular Diseases,Ghent University,Ghent,Belgium.
authors: Ernst R
authors: ER
authors: Rietzschel
authors: Department of Cardiovascular Diseases,Ghent University,Ghent,Belgium.
authors: Marc L
authors: ML
authors: De Buyzere
authors: Asklepios Core-Lab, Department of Laboratory Medicine, AZ St-Jan,Brugge,Belgium.
authors: Michel
authors: M
authors: Langlois
authors: Asklepios Core-Lab, Department of Laboratory Medicine, AZ St-Jan,Brugge,Belgium.
authors: Evi
authors: E
authors: Debruyne
authors: Department of Metabolism and Nutrition,Institute of Food Science and Technology and Nutrition,Madrid,Spain.
authors: Ascensión
authors: A
authors: Marcos
authors: Department of Public Health,Ghent University,Ghent,Belgium.
authors: Inge
authors: I
authors: Huybrechts
mesh_terms: D000328:Adult; D001530:Belgium / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D003430:Cross-Sectional Studies; D004032:Diet / Q000009:adverse effects* / Q000208:ethnology; D004034:Diet Surveys; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D006710:Homocysteine
keywords: Chronic disease risk
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