title: Gold-silica quantum rattles for multimodal imaging and therapy.
abstract: Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell's central cavity. This "quantum rattle" structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.
authors: Department of Materials, Institute of Biomedical Engineering, and Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom;
authors: Mathew
authors: M
authors: Hembury
authors: Department of Materials, Institute of Biomedical Engineering, and Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom;
authors: Ciro
authors: http://orcid.org/0000-0002-9893-4359
authors: C
authors: Chiappini
authors: Department of Materials, Institute of Biomedical Engineering, and.
authors: Sergio
authors: S
authors: Bertazzo
authors: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom;
authors: Tammy L
authors: TL
authors: Kalber
authors: Sorbonne Universités, Université Pierre et Marie Curie Paris 6, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; Collège de France, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75231 Paris, France;
authors: Glenna L
authors: GL
authors: Drisko
authors: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom; Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom; and.
authors: Olumide
authors: O
authors: Ogunlade
authors: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom;
authors: Simon
authors: S
authors: Walker-Samuel
authors: Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA 70806.
authors: Katla Sai
authors: KS
authors: Krishna
authors: Department of Materials, Institute of Biomedical Engineering, and Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom;
authors: Coline
authors: C
authors: Jumeaux
authors: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom; Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom; and.
authors: Paul
authors: P
authors: Beard
authors: Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA 70806.
authors: Challa S S R
authors: CS
authors: Kumar
authors: Department of Materials.
authors: Alexandra E
authors: AE
authors: Porter
authors: Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom;
authors: Mark F
authors: MF
authors: Lythgoe
authors: Sorbonne Universités, Université Pierre et Marie Curie Paris 6, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; Collège de France, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75231 Paris, France;
authors: Cédric
authors: C
authors: Boissière
authors: Sorbonne Universités, Université Pierre et Marie Curie Paris 6, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75005 Paris, France; Collège de France, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris, F-75231 Paris, France;
authors: Clément
authors: C
authors: Sanchez
authors: Department of Materials, Institute of Biomedical Engineering, and Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom; m.stevens@imperial.ac.uk.
authors: Molly M
authors: MM
authors: Stevens
mesh_terms: D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D046529:Microscopy, Electron, Transmission; D064847:Multimodal Imaging; D010789:Phototherapy; D045663:Quantum Dots; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D006046:Gold; D012822:Silicon Dioxide
keywords: cancer nanotechnology; gold quantum dots; hybrid nanoparticle; mesoporous silica; nanomedicine
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