title: Five-year follow-up of 23 asymmetrical Parkinson's disease patients treated with unilateral subthalamic nucleus stimulation.
abstract: In this study, 23 asymmetrical Parkinson's disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson's Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson's Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson's disease patients presenting no severe axial symptoms and dyskinesias.
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Jinchuan
authors: J
authors: Liang
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Xiaowu
authors: X
authors: Hu
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Xiaoping
authors: X
authors: Zhou
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Xiufeng
authors: X
authors: Jiang
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Yiqun
authors: Y
authors: Cao
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Laixing
authors: L
authors: Wang
authors: Department of Radiology, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Aiguo
authors: A
authors: Jin
authors: Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China.
authors: Jianmin
authors: J
authors: Liu
keywords: Parkinson's disease; deep brain stimulation; neural regeneration; subthalamic nucleus
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