title: Pancreatic cancer-associated diabetes is an "exosomopathy".
abstract: Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.
authors: Department of Medicine, and Biochemistry and Molecular Biology, The Melvin and Bren Simon Cancer Center, and the Center for Pancreatic Cancer Research, Indiana University School of Medicine, Indianapolis, Indiana. mkorc@iu.edu.
authors: Murray
authors: M
authors: Korc
mesh_terms: D053607:Adrenomedullin / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000209:etiology*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000150:complications*
chemical_list: D053607:Adrenomedullin
references: Clin Cancer Res. 2015 Apr 1;21(7):1722-33
references: 25355928
references: Biochem Soc Trans. 2002 Aug;30(4):432-7
references: 12196109
references: Mol Cancer. 2003 Jan 6;2:4
references: 12556242
references: J Clin Invest. 1994 Nov;94(5):2158-61
references: 7962564
references: Gastroenterology. 2008 Apr;134(4):981-7
references: 18395079
references: Am J Gastroenterol. 2014 Dec;109(12):1942-52
references: 25350767
references: Nat Rev Gastroenterol Hepatol. 2013 Jul;10(7):423-33
references: 23528347
references: Nat Rev Drug Discov. 2013 Sep;12(9):703-19
references: 23989796
references: Cancer Res. 2014 Jun 1;74(11):2913-21
references: 24840647
references: Diabetes Care. 2014 Dec;37(12):3172-9
references: 25414388
references: Gastroenterology. 2013 Jun;144(6):1252-61
references: 23622135