title: Hypothermic machine perfusion of kidneys retrieved from standard and high-risk donors.
abstract: Hypothermic machine perfusion (HMP) of kidneys is a long-established alternative to static cold storage and has been suggested to be a better preservation method. Today, as our deceased donor profile continues to change towards higher-risk kidneys of lower quality, we are confronted with the limits of cold storage. Interest in HMP as a preservation technique is on the rise. Furthermore, HMP also creates a window of opportunity during which to assess the viability and quality of the graft before transplantation. The technology might also provide a platform during which the graft could be actively repaired, making it particularly attractive for higher-risk kidneys. We review the current evidence on HMP in kidney transplantation and provide an outlook for the use of the technology in the years to come.
authors: Department of Microbiology and Immunology, Abdominal Transplantation, KU Leuven - University of Leuven, Leuven, Belgium.|Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
authors: Ina
authors: I
authors: Jochmans
authors: Nuffield Department of Surgical Sciences, Biomedical Research Centre and Oxford Transplant Centre, University of Oxford, Oxford, UK.|Centre for Evidence in Transplantation, Royal College of Surgeons of England and London School of Hygiene and Tropical Medicine, London, UK.
authors: John M
authors: JM
authors: O'Callaghan
authors: Department of Microbiology and Immunology, Abdominal Transplantation, KU Leuven - University of Leuven, Leuven, Belgium.|Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
authors: Jacques
authors: J
authors: Pirenne
authors: Nuffield Department of Surgical Sciences, Biomedical Research Centre and Oxford Transplant Centre, University of Oxford, Oxford, UK.
authors: Rutger J
authors: RJ
authors: Ploeg
mesh_terms: D003080:Cold Temperature; D046148:Donor Selection; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000295:instrumentation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D010100:Oxygen / Q000737:chemistry; D010477:Perfusion / Q000295:instrumentation / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D033581:Stem Cell Transplantation; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D019188:Organ Preservation Solutions; D010100:Oxygen
keywords: delayed graft function; donation after brain death; donation after circulatory death; expanded criteria donors; extended criteria donors; graft quality; history of machine perfusion; hypothermic machine perfusion; kidney transplantation; organ preservation; perfusate biomarkers; renal resistance; viability assessment