title: Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations.
abstract: Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London.
authors: David J
authors: DJ
authors: Jackson
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma.
authors: Nicholas
authors: N
authors: Glanville
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London.
authors: Maria-Belen
authors: MB
authors: Trujillo-Torralbo
authors: Novartis Institute for Biomedical Research, Horsham, United Kingdom.
authors: Betty W H
authors: BW
authors: Shamji
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London.
authors: Jerico
authors: J
authors: Del-Rosario
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London.
authors: Patrick
authors: P
authors: Mallia
authors: Novartis Institute for Biomedical Research, Horsham, United Kingdom.
authors: Matthew J
authors: MJ
authors: Edwards
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma.
authors: Ross P
authors: RP
authors: Walton
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma.
authors: Michael R
authors: MR
authors: Edwards
authors: Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London.
authors: Sebastian L
authors: SL
authors: Johnston
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D003139:Common Cold / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020545:Respiratory Mucosa / Q000737:chemistry; D012229:Rhinovirus / Q000276:immunology*
chemical_list: D020382:Interleukin-18
keywords: asthma; inflammasome; interleukin-18; rhinovirus infection