title: Humoral response against small heat shock proteins in Parkinson's disease.
abstract: BACKGROUND
  In the light of evidence for the increased heat shock proteins (HSP) expression in neurodegenerative disorders, the presence of the adaptive humoral response of the immune system can be expected. The aim of the study was to check whether Parkinson's disease (PD) has the ability to elicit immune response against small heat shock proteins.
  
  
  METHODS
  IgG and IgM autoantibodies against alpha B-crystallin were assessed in 26 PD patients 26 healthy subjects. For the assessment of anti-HSP IgG autoantibodies serum samples from 31 parkinsonian patients and 31 healthy control subjects were collected. Serum samples from PD patients and healthy control subjects were collected twice, at baseline and after mean of 13 months follow up.
  
  
  RESULTS
  Both IgM and IgG autoantibodies against alpha ß-crystallin in PD patients were significantly higher compared to healthy controls (p<0.05). We also found statistically significant increase in antibodies titers against alpha ß-crystallin over the time of 13 months, both for IgG (p = 0.021) and for IgM (p<0.0001). Additionally, PD patients presented higher levels of anti-HSP IgG autoantibodies than healthy controls (p = 0.02).
  
  
  CONCLUSIONS
  Increase of IgG and IgM autoantibodies against alpha B-crystallin in PD patients over time may suggest their involvement in the disease pathogenesis and progression. Further studies are required to confirm the role of this antibody as a biomarker of the disease progression.
authors: Chair and Department of Neurology of Medical University, Lublin, Poland.
authors: Ewa
authors: E
authors: Papuć
authors: 2nd Department of Radiology, Medical University, Lublin, Poland.
authors: Ewa
authors: E
authors: Kurys-Denis
authors: 2nd Department of Radiology, Medical University, Lublin, Poland.
authors: Witold
authors: W
authors: Krupski
authors: Chair and Department of Neurology of Medical University, Lublin, Poland.
authors: Konrad
authors: K
authors: Rejdak
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D050888:Heat-Shock Proteins, Small / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000276:immunology*; D038203:alpha-Crystallin B Chain / Q000276:immunology
chemical_list: D001323:Autoantibodies; D050888:Heat-Shock Proteins, Small; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D038203:alpha-Crystallin B Chain
references: Biochem Biophys Res Commun. 1999 Aug 19;262(1):152-6
references: 10448084
references: Cell Stress Chaperones. 1999 Mar;4(1):29-35
references: 10467106
references: Acta Neuropathol. 2000 Jan;99(1):14-20
references: 10651022
references: Isr Med Assoc J. 1999 Dec;1(4):272-7
references: 10731361
references: J Autoimmun. 2000 Sep;15(2):199-202
references: 10968909
references: J Neurochem. 2001 Jan;76(1):87-96
references: 11145981
references: Eur J Clin Invest. 2001 Apr;31(4):285-92
references: 11298774
references: Exp Eye Res. 2003 Feb;76(2):145-53
references: 12565801
references: Autoimmun Rev. 2004 Jun;3 Suppl 1:S30-1
references: 15309783
references: J Biol Chem. 2005 Apr 15;280(15):14733-40
references: 15671022
references: Biochem J. 2005 Dec 15;392(Pt 3):573-81
references: 16053447
references: Cell Mol Life Sci. 2005 Nov;62(21):2460-76
references: 16143830
references: Brain Res. 2006 May 17;1089(1):67-78
references: 16635482
references: Adv Exp Med Biol. 2007;594:1-13
references: 17205670
references: Int J Exp Pathol. 2007 Aug;88(4):249-55
references: 17696906
references: Parkinsonism Relat Disord. 2009 May;15(4):318-20
references: 18672391
references: Autoimmun Rev. 2009 Mar;8(5):388-93
references: 19121415
references: Biophys J. 2010 Mar 3;98(5):843-51
references: 20197038
references: Acta Physiol Hung. 2010 Mar;97(1):1-10
references: 20233685
references: Microbiol Immunol. 2010 May;54(5):299-307
references: 20536727
references: Immunol Today. 1991 Apr;12(4):105-10
references: 2059311
references: Cell Stress Chaperones. 2010 Nov;15(6):1013-26
references: 20632140
references: J Immunol. 2011 Apr 1;186(7):4263-8
references: 21357544
references: Autoimmune Dis. 2013;2013:621417
references: 23762533
references: Autoimmun Rev. 2014 Oct;13(10):1013-9
references: 25183243
references: Eur J Immunol. 1995 Sep;25(9):2598-604
references: 7589132
references: J Immunol. 1995 Jun 1;154(11):5769-78
references: 7751627
references: Curr Opin Immunol. 1995 Dec;7(6):812-8
references: 8679125
references: Scand J Immunol. 1996 Sep;44(3):243-51
references: 8795718