title: Decision-making in the management of adult classical Hodgkin's lymphoma: determining the optimal treatment.
abstract: This review discusses promising new approaches in classical Hodgkin's lymphoma that have been recently evaluated. There is a focus on the fluorodeoxyglucose PET scanning that is now considered crucial for staging and treatment evaluation, including interim evaluation after two cycles. An up-front treatment strategy is discussed, with the place of radiation therapy and the difficult choice of chemotherapy intensity emphasized. Indications for frail patients are also reviewed, particularly elderly or HIV-positive patients. Emerging data on the antibody drug conjugate brentuximab vedotin and its future potential in the transplantation framework for relapsed/refractory Hodgkin's lymphoma is also discussed.
authors: Onco-Hematology Department, l'Archet Hospital, Nice, France.
authors: Nicolas
authors: N
authors: Mounier
authors: Mounier
authors: M
authors: Nicolas
authors: Christian
authors: C
authors: Gisselbrecht
authors: Gisselbrecht
authors: G
authors: Christian
mesh_terms: D003657:Decision Making; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D011379:Prognosis; D016896:Treatment Outcome
keywords: Hodgkin; PET imaging; chemotherapy; molecular profiles; targeted drugs; transplantation