title: Heart failure and atrial fibrillation: from basic science to clinical practice.
abstract: Heart failure (HF) and atrial fibrillation (AF) are two growing epidemics associated with significant morbidity and mortality. They often coexist due to common risk factors and shared pathophysiological mechanisms. Patients presenting with both HF and AF have a worse prognosis and present a particular therapeutic challenge to clinicians. This review aims to appraise the common pathophysiological background, as well as the prognostic and therapeutic implications of coexistent HF and AF.
authors: Internal Medicine Department, Centro Hospitalar do Porto, Porto 4099-001, Portugal. u10161@chporto.min-saude.pt.|Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal. u10161@chporto.min-saude.pt.
authors: João Pedro
authors: JP
authors: Ferreira
authors: Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal. mariossantos001@gmail.com.|Cardiology Department, Centro Hospitalar do Porto, Porto 4099-001, Portugal. mariossantos001@gmail.com.
authors: Mário
authors: M
authors: Santos
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D009765:Obesity / Q000473:pathology; D012084:Renin-Angiotensin System; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium
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