title: Serum adipokine concentrations in dogs with diabetes mellitus: a pilot study.
abstract: This study was conducted to determine whether serum adipokine concentrations differed between healthy dogs and dogs with diabetes mellitus (DM). To accomplish this, 19 dogs with newly diagnosed DM were compared to 20 otherwise healthy dogs. The serum concentrations of visfatin, leptin, IL-1β, IL-6, IL-18, and TNF-α were significantly higher in diabetic dogs than in healthy dogs, whereas the serum adiponectin concentrations were lower in diabetic dogs. However, there were no significant differences in the IL-10 and resistin levels between groups. The serum leptin concentrations in diabetic dogs with and without concurrent disorders differed significantly. Treatment with insulin induced a significant decrease in IL-6 in diabetic dogs without concurrent disorders. These results show that the clinical diabetic state of dogs could modulate the circulating visfatin and adiponectin concentrations directly, while upregulation of leptin was probably a result of concurrent disorders rather than an effect of persistent hyperglycemia as a result of DM.
authors: Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.
authors: Ah Young
authors: AY
authors: Kim
authors: Hye-Sun
authors: HS
authors: Kim
authors: Ji-Houn
authors: JH
authors: Kang
authors: Mhan-Pyo
authors: MP
authors: Yang
mesh_terms: D054392:Adipokines / Q000097:blood*; D000818:Animals; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology; D004285:Dogs; D005260:Female; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D054392:Adipokines
keywords: adiponectin; canine; interleukin; leptin; visfatin
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