title: Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans.
abstract: Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute configurations were assigned by CD calculations. The acetylcholinesterase (AchE) inhibitory activity of compounds 1 and 2 was evaluated, both of which showed moderate activity with IC50 values of 11.8 and 13.5μM, respectively.
authors: School of Pharmacy, Nantong University, Nantong 226001, China.
authors: Jian Lin
authors: JL
authors: Li
authors: School of Pharmacy, Nantong University, Nantong 226001, China.
authors: Lei
authors: L
authors: Huang
authors: Key Laboratory of Tropical Marine Bio-resource and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
authors: Juan
authors: J
authors: Liu
authors: School of Pharmacy, Nantong University, Nantong 226001, China.
authors: Yan
authors: Y
authors: Song
authors: Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong 226001, China.
authors: Jie
authors: J
authors: Gao
authors: College of Pharmacy, Pusan National University, Busan 609735, South Korea.
authors: Jee H
authors: JH
authors: Jung
authors: Key Laboratory of Tropical Marine Bio-resource and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
authors: Yonghong
authors: Y
authors: Liu
authors: School of Pharmacy, Nantong University, Nantong 226001, China. Electronic address: guangtong_chen@163.com.
authors: Guangtong
authors: G
authors: Chen
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000190:Actinomyces / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology
chemical_list: D002800:Cholinesterase Inhibitors; D007211:Indoles; D000110:Acetylcholinesterase
keywords: AchE inhibitory activity; Dimeric indole derivatives; Marine actinomycetes; Rubrobacter radiotolerans