title: The translational significance of epithelial-mesenchymal transition in head and neck cancer.
abstract: Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents.
authors: Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Bldg. 1 Room B43 6439 Garners Ferry Rd, Columbia, SC 29208 USA ; Department of Head and Neck Surgery, Wm. Jennings Dorn VA Medical Center, Columbia, SC 29208 USA.
authors: Christian A
authors: CA
authors: Graves
authors: Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Bldg. 1 Room B43 6439 Garners Ferry Rd, Columbia, SC 29208 USA.
authors: Fadi F
authors: FF
authors: Abboodi
authors: Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Bldg. 1 Room B43 6439 Garners Ferry Rd, Columbia, SC 29208 USA.
authors: Swati
authors: S
authors: Tomar
authors: Department of Head and Neck Surgery, Wm. Jennings Dorn VA Medical Center, Columbia, SC 29208 USA.
authors: James
authors: J
authors: Wells
authors: Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Bldg. 1 Room B43 6439 Garners Ferry Rd, Columbia, SC 29208 USA.
authors: Lucia
authors: L
authors: Pirisi
keywords: Biomarkers; Clinical trials in HNSC; EMT and HPV; EMT head and Neck cancer; Slug; Snail; TGF beta and Head and Neck cancer
references: Clin Cancer Res. 2010 Mar 1;16(5):1416-22
references: 20179236
references: Br J Cancer. 2013 Oct 15;109 (8):2248-58
references: 24045665
references: Cancer Res. 2007 May 15;67(10):4605-19
references: 17510386
references: Cancer Res. 2003 Apr 15;63(8):1727-30
references: 12702551
references: J Clin Invest. 2010 Aug;120(8):2842-57
references: 20592473
references: Mol Biol Cell. 2008 Nov;19(11):4738-49
references: 18716062
references: Nat Rev Drug Discov. 2012 Oct;11(10):790-811
references: 23000686
references: Cancer Res. 2006 Aug 15;66(16):8210-8
references: 16912200
references: J Cell Biol. 1982 Oct;95(1):333-9
references: 7142291
references: J Cell Biochem. 2008 Jun 1;104(3):826-39
references: 18189245
references: Cancer Res. 2004 Jan 1;64(1):55-63
references: 14729608
references: Cell Signal. 2006 May;18(5):679-87
references: 16084063
references: Biomarkers. 2012 Feb;17(1):21-7
references: 22106837
references: Mol Cell Proteomics. 2012 Nov;11(11):1404-15
references: 22918226
references: Oral Oncol. 2008 Sep;44(9):823-9
references: 18203652
references: Rev Physiol Biochem Pharmacol. 1984;99:111-81
references: 6320328
references: Clin Cancer Res. 2009 Oct 1;15(19):6284-91
references: 19773378
references: Cancer Res. 2014 Feb 15;74(4):1091-104
references: 24351288
references: J Virol. 2004 Apr;78(8):3953-64
references: 15047811
references: Cancer Res. 2007 Oct 1;67(19):9207-13
references: 17909026
references: Clin Chem Lab Med. 2013 Jun;51(6):1291-300
references: 23154424
references: Open Virol J. 2007;1:33-8
references: 19440457
references: Laryngoscope. 2003 Jan;113(1):161-6
references: 12514402
references: Biomed Res Int. 2014;2014:948264
references: 24511551
references: J Oral Pathol Med. 2014 Oct;43(9):652-7
references: 24762262
references: Eur J Cell Biol. 2003 Jun;82(6):313-22
references: 12868599
references: Br J Cancer. 2010 Mar 2;102(5):892-7
references: 20145620
references: Proc Natl Acad Sci U S A. 2008 Apr 29;105(17 ):6392-7
references: 18427106
references: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6064-72
references: 17062682
references: J Clin Invest. 2009 Jun;119(6):1420-8
references: 19487818
references: Arch Otolaryngol. 1980 Nov;106(11):672-4
references: 7425937
references: Oral Oncol. 2013 Apr;49(4):287-92
references: 23182398
references: Biochem Biophys Res Commun. 2013 Jun 7;435(3):339-44
references: 23628416
references: J Oral Pathol Med. 2003 Mar;32(3):139-45
references: 12581383
references: Oral Oncol. 2013 Nov;49(11):1043-50
references: 24035721
references: Oncogene. 2010 Apr 8;29(14):2047-59
references: 20101235
references: Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30
references: 22992590
references: Br J Dermatol. 1974 Nov;91(5):569-71
references: 4373025
references: PLoS Comput Biol. 2009 Nov;5(11):e1000571
references: 19936049
references: Nat Rev Cancer. 2005 Feb;5(2):127-35
references: 15685196
references: Nat Rev Cancer. 2011 Jan;11(1):9-22
references: 21160525
references: Mol Cancer. 2010 May 12;9:106
references: 20462450
references: Cell Growth Differ. 1992 Nov;3(11):763-72
references: 1334692
references: Virology. 2013 Dec;447(1-2):63-73
references: 24210100
references: Laryngoscope. 2009 Aug;119(8):1518-30
references: 19507218
references: Oncotarget. 2011 Dec;2(12 ):1165-75
references: 22201613
references: Lancet Oncol. 2010 Aug;11(8):781-9
references: 20451455
references: Int J Cancer. 2006 Oct 15;119(8):1761-6
references: 16708382
references: Anticancer Res. 2007 Sep-Oct;27(5A):3121-6
references: 17970052
references: BMC Cancer. 2011 Aug 11;11:350
references: 21834956
references: J Oral Pathol Med. 2004 Jul;33(6):317-22
references: 15200478
references: Am J Surg. 1980 Oct;140(4):527-30
references: 7425237
references: Am J Pathol. 1932 Jan;8(1):43-56.7
references: 19969997
references: PLoS One. 2014 Mar 27;9(3):e91263
references: 24675808
references: Br J Cancer. 2011 Mar 29;104(7):1160-7
references: 21386845
references: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
references: 16801545
references: Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
references: 24556840
references: Acta Otorhinolaryngol Ital. 2013 Apr;33(2):77-87
references: 23853396
references: Clin Cancer Res. 2009 Oct 1;15(19):6018-27
references: 19789323
references: Virology. 2000 May 10;270(2):408-16
references: 10793000
references: Oncogene. 2010 Oct 7;29(40):5437-46
references: 20676130
references: Cell Death Differ. 2014 Mar;21(3):462-74
references: 24270410
references: Cell. 1993 Dec 3;75(5):843-54
references: 8252621
references: BMC Cancer. 2013 Sep 18;13:424
references: 24047375
references: Clin Cancer Res. 2014 May 1;20(9):2300-11
references: 24599934
references: Am J Otolaryngol. 2012 Jan-Feb;33(1):6-13
references: 21439681
references: J Exp Clin Cancer Res. 2014 May 10;33:40
references: 24887090
references: Cancer Biomark. 2011;10(5):241-9
references: 22699785
references: Cancer Biol Ther. 2010 Sep 15;10(6):644-53
references: 20703101
references: Science. 2011 Aug 26;333(6046):1154-7
references: 21798897
references: Sci Rep. 2013 Oct 02;3:2650
references: 24084849
references: Histopathology. 2008 Jul;53(1):62-72
references: 18540978
references: Oral Oncol. 2012 Jan;48(1):1-9
references: 22070916
references: Adv Exp Med Biol. 1995;375:117-35
references: 7645423
references: J Cancer Res Clin Oncol. 2014 Jun;140(6):1011-9
references: 24615330
references: Head Neck. 2013 Jul;35(7):942-8
references: 22791234
references: Proc Finn Dent Soc. 1983;79(1):1-8
references: 6306646
references: Nature. 1998 Mar 12;392(6672):190-3
references: 9515965
references: Clin Cancer Res. 2013 Aug 1;19(15):4174-84
references: 23757353
references: Cancer Res. 1960 Aug;20:1083-93
references: 13809073
references: Virology. 2000 May 10;270(2):397-407
references: 10792999
references: PLoS One. 2013;8(2):e56823
references: 23451093
references: Otolaryngol Head Neck Surg. 2009 Mar;140(3):375-80
references: 19248946
references: Cancer Res. 2013 Jun 1;73(11):3381-92
references: 23576557
references: Oncogene. 2000 Jun 29;19(28):3220-4
references: 10918578
references: Ann Surg Oncol. 2012 Feb;19(2):612-9
references: 21913013
references: Clin Cancer Res. 2008 Jul 1;14 (13):4085-95
references: 18593985
references: Cancer Res. 2005 Jul 15;65(14):5996-6000; discussion 6000-1
references: 16024596
references: Nature. 2013 Oct 17;502(7471):333-9
references: 24132290
references: Int J Cancer. 2008 Jul 1;123(1):32-40
references: 18398830
references: Cancer Res. 2002 Feb 15;62(4):1184-90
references: 11861402
references: PLoS One. 2012;7(12):e51967
references: 23300583
references: Carcinogenesis. 2014 Jun;35(6):1379-88
references: 24574515
references: BMC Cancer. 2009 Oct 18;9:370
references: 19835631
references: Cancer. 1953 Sep;6(5):963-8
references: 13094644
references: Oncogene. 2012 Jul 12;31(28):3322-32
references: 22037217
references: Laryngoscope. 2010 Aug;120(8):1531-7
references: 20564751
references: Virchows Arch. 2009 Jul;455(1):67-75
references: 19543744
references: Cancer Res. 2014 Jul 15;74(14):3995-4005
references: 24830724
references: J Clin Invest. 2013 Jun;123(6):2488-501
references: 23635773
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: J Pathol. 1996 May;179(1):66-73
references: 8691348
references: Cancer Lett. 2009 Sep 18;282(2):177-86
references: 19344999
references: N Engl J Med. 2008 Sep 11;359(11):1116-27
references: 18784101
references: Best Pract Res Clin Obstet Gynaecol. 2011 Oct;25(5):565-74
references: 21708487
references: CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36
references: 21685461
references: Eur J Cancer. 2012 Nov;48(17):3310-8
references: 22640830
references: N Engl J Med. 2006 Feb 9;354(6):567-78
references: 16467544
references: J Virol. 1987 Apr;61(4):1061-6
references: 2434663
references: Nat Cell Biol. 2008 Mar;10 (3):295-305
references: 18297062
references: Science. 2011 Aug 26;333(6046):1157-60
references: 21798893
references: Oncogene. 2007 Mar 1;26(10 ):1459-67
references: 16936774
references: PLoS One. 2012;7(1):e30246
references: 22276165
references: Oncol Lett. 2012 Feb;3(2):273-280
references: 22740894
references: Virchows Arch. 2009 May;454(5):549-55
references: 19381684
references: Trends Genet. 2012 Sep;28(9):454-63
references: 22717049
references: CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
references: 17237035
references: Nat Rev Cancer. 2002 Jun;2(6):442-54
references: 12189386