title: Pulmonary hypertension management in neonates.
abstract: The management of pulmonary hypertension is multi-faceted, with therapies directed at supporting cardiovascular and pulmonary function, treating the underlying cause (if feasible), and preventing irreversible remodeling of the pulmonary vasculature. Recently, manipulation of signaling pathways and mediators contained within the pulmonary vascular endothelial cell has become a new target. This article will review the pathophysiology of pulmonary hypertension and the broad principles involved in its management, with specific emphasis on pharmacological therapies directed at the pulmonary vascular endothelium.
authors: Division of Pediatric General and Thoracic Surgery, The Montreal Children׳s Hospital, Room C811, 2300 Tupper St, Montreal, Quebec H3H 1P3, Canada.
authors: Kartikey A
authors: KA
authors: Pandya
authors: Division of Pediatric General and Thoracic Surgery, The Montreal Children׳s Hospital, Room C811, 2300 Tupper St, Montreal, Quebec H3H 1P3, Canada; Division of Pediatric Critical Care Medicine, Montreal Children's Hospital, Room C811, 2300 Tupper St, Montreal, Quebec H3H 1P3, Canada. Electronic address: pramod.puligandla@mcgill.ca.
authors: Pramod S
authors: PS
authors: Puligandla
mesh_terms: D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply* / Q000503:physiopathology
chemical_list: D002317:Cardiovascular Agents
keywords: Neonate; Pulmonary hypertension; Pulmonary vascular endothelium; Pulmonary vascular resistance; Pulmonary vasodilators