title: Crimean-Congo hemorrhagic fever: CXCL10 correlates with the viral load.
abstract: Crimean-Congo hemorrhagic fever (CCHF) is a human disease with high fatality rate. Although its pathogenesis is not elucidated yet, it is considered that cytokines play a significant role in the progression and outcome of the disease. Serum CXCL10 levels were estimated in 35 patients with acute CCHF and were correlated with the viral load, and various demographic and clinical parameters. The mean CXCL10 concentration in the patients' group was higher compared to the respective value in the control group (4421.74 pg/ml vs. 28.47 pg/ml, P < 0.05). A strong positive correlation between CXCL10 and viral load was seen (rs = 0.57, P < 0.001), while the outcome of the disease was related with the viral load (rs = 0.47, P = 0.004) and the presence of hemorrhagic manifestations (P < 0.001). The study provides an insight into the strong correlation between CXCL10 and viral load in acute CCHF cases suggesting that it plays an important role in CCHF pathogenesis.
authors: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Greece.
authors: Anna
authors: A
authors: Papa
authors: Dilek
authors: D
authors: Yagci Caglayık
authors: Iva
authors: I
authors: Christova
authors: Katerina
authors: K
authors: Tsergouli
authors: Gulay
authors: G
authors: Korukluoglu
authors: Yavuz
authors: Y
authors: Uyar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology / Q000502:physiology*; D006479:Hemorrhagic Fever, Crimean / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D019562:Viral Load; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10
keywords: CXCL10; Crimean-Congo hemorrhagic fever; viral load