title: A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b).
abstract: OBJECTIVE
  The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes.
  
  
  METHODS
  Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction.
  
  
  RESULTS
  We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported.
  
  
  CONCLUSIONS
  The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.
authors: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN. Electronic address: dahaas@iupui.edu.
authors: David M
authors: DM
authors: Haas
authors: RTI International, Research Triangle Park, NC.
authors: Corette B
authors: CB
authors: Parker
authors: Department of Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Irvine, CA.
authors: Deborah A
authors: DA
authors: Wing
authors: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA.
authors: Samuel
authors: S
authors: Parry
authors: Feinberg School of Medicine, Northwestern University, Evanston, IL.
authors: William A
authors: WA
authors: Grobman
authors: Case Western Reserve University School of Medicine, Cleveland, OH.
authors: Brian M
authors: BM
authors: Mercer
authors: Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors: Hyagriv N
authors: HN
authors: Simhan
authors: Christiana Care Health System, Newark, DE.
authors: Matthew K
authors: MK
authors: Hoffman
authors: University of Utah School of Medicine, Salt Lake City, UT.
authors: Robert M
authors: RM
authors: Silver
authors: Department of Psychiatry, University of California, Irvine, School of Medicine, Irvine, CA.
authors: Pathik
authors: P
authors: Wadhwa
authors: The Ohio State University College of Medicine, Columbus, OH.
authors: Jay D
authors: JD
authors: Iams
authors: RTI International, Research Triangle Park, NC.
authors: Matthew A
authors: MA
authors: Koch
authors: Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors: Steve N
authors: SN
authors: Caritis
authors: College of Physicians and Surgeons, Columbia University, New York, NY.
authors: Ronald J
authors: RJ
authors: Wapner
authors: University of Utah School of Medicine, Salt Lake City, UT.
authors: M Sean
authors: MS
authors: Esplin
authors: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA.
authors: Michal A
authors: MA
authors: Elovitz
authors: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
authors: Tatiana
authors: T
authors: Foroud
authors: Feinberg School of Medicine, Northwestern University, Evanston, IL.
authors: Alan M
authors: AM
authors: Peaceman
authors: University of Texas Medical Branch, Galveston, TX.
authors: George R
authors: GR
authors: Saade
authors: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
authors: Marian
authors: M
authors: Willinger
authors: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
authors: Uma M
authors: UM
authors: Reddy
mesh_terms: D000293:Adolescent; D000328:Adult; D002985:Clinical Protocols; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006801:Humans; D010298:Parity; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology*; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D055815:Young Adult
keywords: adverse pregnancy outcome; cohort study; methods; nulliparous; prediction; pregnancy; psychosocial
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