title: Epistasis can accelerate adaptive diversification in haploid asexual populations.
abstract: A fundamental goal of the biological sciences is to determine processes that facilitate the evolution of diversity. These processes can be separated into ecological, physiological, developmental and genetic. An ecological process that facilitates diversification is frequency-dependent selection caused by competition. Models of frequency-dependent adaptive diversification have generally assumed a genetic basis of phenotype that is non-epistatic. Here, we present a model that indicates diversification is accelerated by an epistatic basis of phenotype in combination with a competition model that invokes frequency-dependent selection. Our model makes use of a genealogical model of epistasis and insights into the effects of balancing selection on the genealogical structure of a population to understand how epistasis can facilitate diversification. The finding that epistasis facilitates diversification may be informative with respect to empirical results that indicate an epistatic basis of phenotype in experimental bacterial populations that experienced adaptive diversification.
authors: Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada N1H 2W1 cgriswol@uoguelph.ca.
authors: Cortland K
authors: CK
authors: Griswold
mesh_terms: D000222:Adaptation, Physiological; D001419:Bacteria / Q000235:genetics; D005075:Biological Evolution; D004843:Epistasis, Genetic; D006238:Haploidy; D008957:Models, Genetic; D010641:Phenotype; D012100:Reproduction, Asexual; D012641:Selection, Genetic
keywords: adaptive diversification; coalescent; epistasis; frequency-dependence
references: Nature. 2003 Jan 16;421(6920):259-64
references: 12529641
references: BMC Evol Biol. 2008;8:34
references: 18234105
references: Am Nat. 2003 May;161(5):708-34
references: 12858280
references: Science. 2003 Aug 15;301(5635):961-4
references: 12920297
references: Nature. 1998 Jul 2;394(6688):69-72
references: 9665128
references: Nature. 1999 Jul 22;400(6742):354-7
references: 10432112
references: Theor Popul Biol. 2005 Nov;68(3):179-96
references: 16122771
references: Science. 2006 Apr 7;312(5770):111-4
references: 16601193
references: Trends Ecol Evol. 2006 May;21(5):238-45
references: 16697909
references: Science. 2010 Apr 23;328(5977):494-7
references: 20413499
references: Mol Ecol. 2010 Jun 1;19(12):2430-8
references: 20497320
references: Science. 2011 Mar 18;331(6023):1433-6
references: 21415350
references: Science. 2011 Jun 3;332(6034):1190-2
references: 21636771
references: Science. 2011 Jun 3;332(6034):1193-6
references: 21636772
references: Theor Popul Biol. 2012 Feb;81(1):32-44
references: 22100752
references: Theor Popul Biol. 2012 Nov;82(3):209-21
references: 22771491
references: Biol Lett. 2013 Feb 23;9(1):20120328
references: 22896270
references: Evolution. 2014 May;68(5):1365-73
references: 24433364
references: Evolution. 2006 Aug;60(8):1523-36
references: 17017054
references: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1585-9
references: 18216261
references: Evolution. 2003 Jan;57(1):27-36
references: 12643565