title: Hypolipidemic Activity of Cassia tora Seeds in Hyperlipidemic Rats.
abstract: The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of Triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats. Feeding with C. tora seed extract at the dose of 500 mg/kg, b.w. exerted significant lipid lowering effect as assessed by the reversal of plasma levels of total cholesterol, phospholipids, triglyceride and reactivation of post heparin lipolytic activity. In the chronic model, hyperlipidemia was induced by feeding with cholesterol rich-HFD in rats. The treatment with seeds extract of C. tora (500 mg/kg, b.w.) simultaneously for 15 days also caused lowering of lipid levels in plasma and liver following reactivation of plasma post heparin lipolytic activity and hepatic lipoprotein lipase activity in animals. The hypolipidemic activity of C. tora seeds was compared with a standard drug guggulipid (200 mg/kg, b.w.) in both models.
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow, 226003 India.
authors: Vishnu Kumar
authors: VK
authors: Awasthi
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow, 226003 India.
authors: Farzana
authors: F
authors: Mahdi
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow, 226003 India.
authors: Ramesh
authors: R
authors: Chander
authors: Division of Biochemistry, Central Drug Research Institute, Lucknow, 226001 India.
authors: Ashok Kumar
authors: AK
authors: Khanna
authors: Division of Biochemistry, Central Drug Research Institute, Lucknow, 226001 India.
authors: Jitendra Kumar
authors: JK
authors: Saxena
authors: Department of Biochemistry, King George's Medical University, Lucknow, 226003 India.
authors: Ranjana
authors: R
authors: Singh
authors: Department of Biochemistry, King George's Medical University, Lucknow, 226003 India.
authors: Abbas Ali
authors: AA
authors: Mahdi
authors: Department of Biochemistry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Patel Nagar, Dehradun, 248001 India.
authors: Raj Kumar
authors: RK
authors: Singh
keywords: Cassia tora seeds; Cholesterol rich-HFD; Hepatic LPL activity; Hepatic steatosis; Hypolipidemic agent; PHLA; Triton model of hyperlipidemia
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