title: No beneficial effects of vitamin D supplementation on muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial.
abstract: BACKGROUND
  Impairments of muscle function and strength in patients with primary hyperparathyroidism (PHPT) are rarely addressed, although decreased muscle function may contribute to increased fracture risk.
  
  
  OBJECTIVE
  We aimed to assess the changes in muscle strength, muscle function, postural stability, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.
  
  
  METHODS
  A randomized placebo-controlled trial.
  
  
  METHODS
  We included 46 PHPT patients, mean age 58 (range 29-77) years and 35 (76%) were women.
  
  
  METHODS
  Daily treatment with 70 μg (2800 IU) cholecalciferol or placebo for 52 weeks. Treatment was administered 26 weeks before PTX and continued for 26 weeks after PTX.
  
  
  METHODS
  Changes in QoL and measures of muscle strength and function.
  
  
  RESULTS
  Preoperatively, 25-hydroxyvitamin D (25OHD) increased significantly (50-94 nmol/l) compared with placebo (57-52 nmol/l). We did not measure any beneficial effects of supplementation with vitamin D compared with placebo regarding well-being, QoL, postural stability, muscle strength, or function. In all patients, we measured marked improvements in QoL, well-being (P<0.01), muscle strength in the knee flexion and extension (P<0.001), and muscle function tests (P<0.01) after surgical cure. Postural stability improved during standing with eyes closed (P<0.05), but decreased with eyes open (P<0.05).
  
  
  CONCLUSIONS
  Patients with PHPT and 25OHD levels around 50 nmol/l did not benefit from vitamin D supplementation concerning muscle strength, muscle function, postural stability, well-being, or QoL. Independent of preoperative 25OHD levels, PTX improved these parameters.
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark larsrolighed@gmail.com.
authors: Lars
authors: L
authors: Rolighed
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Lars
authors: L
authors: Rejnmark
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Tanja
authors: T
authors: Sikjaer
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Lene
authors: L
authors: Heickendorff
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Peter
authors: P
authors: Vestergaard
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Leif
authors: L
authors: Mosekilde
authors: Breast and Endocrine SectionDepartment of Surgery PDepartment of Endocrinology and Internal MedicineAarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Clinical BiochemistryAarhus University Hospital, NBG, Aarhus, DenmarkDepartment of Endocrinology and Clinical InstituteAalborg University Hospital, Aalborg, Denmark.
authors: Peer
authors: P
authors: Christiansen
mesh_terms: D000328:Adult; D000368:Aged; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000503:physiopathology*; D016105:Parathyroidectomy; D011187:Posture; D011788:Quality of Life; D014807:Vitamin D / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014807:Vitamin D