title: Impact of BMI on gonadorelin-stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty.
abstract: OBJECTIVE
  To clarify the impact of body mass index (BMI) on luteinizing hormone (LH) secretion in response to gonadorelin (GnRH) stimulation testing in girls diagnosed with idiopathic central precocious puberty (ICPP).
  
  
  METHODS
  Retrospective single-center cohort study was carried out in 865 confirmed ICPP girls who underwent GnRH stimulation tests. Pubertal development according to Tanner, sex hormone parameters, and LH secretion in response to GnRH-stimulation was compared.
  
  
  RESULTS
  Around 609 girls were of normal weight (70.4%), while 168 children (19.4%) were overweight, and 88 (10.2%) were obese. Peak LH levels after GnRH were much higher in the normal-weight group, with a median of 9.1 mIU ml(-1) (interquartile 5.2-13.1), compared with the median peak LH in the overweight and obese groups (8.5 mIU ml(-1), interquartile 5.3-11.6, and 6.2 mIU ml(-1), interquartile 5.3-11.0, respectively P < 0.001 for all comparisons). Peak LH/FSH ratio was also lower in the obese group (median 0.6, interquartile 0.68-0.90) compared with the normal-weight (median 0.8, interquartile 0.61-1.11) and overweight (median 0.8, interquartile 0.64-0.92) groups.
  
  
  CONCLUSIONS
  Higher BMI is associated with lower LH response to GnRH-stimulation testing in girls with ICPP. It is recommended that BMI should be considered when interpreting GnRH-stimulation tests.
authors: Division of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors: Jun-Fen
authors: JF
authors: Fu
authors: Jian-Feng
authors: JF
authors: Liang
authors: Xue-Lian
authors: XL
authors: Zhou
authors: Heranmaye C
authors: HC
authors: Prasad
authors: Ju-Hua
authors: JH
authors: Jin
authors: Guan-Ping
authors: GP
authors: Dong
authors: Susan Rogers
authors: SR
authors: Rose
mesh_terms: D015992:Body Mass Index; D002648:Child; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008572:Menarche / Q000097:blood / Q000187:drug effects; D050177:Overweight / Q000097:blood / Q000378:metabolism*; D063766:Pediatric Obesity / Q000097:blood / Q000378:metabolism*; D011629:Puberty, Precocious / Q000097:blood / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone