title: Outcomes in mild acute ischemic stroke treated with intravenous thrombolysis: a retrospective analysis of the Get With the Guidelines-Stroke registry.
abstract: OBJECTIVE
  Mild strokes have been poorly represented in thrombolytic trials and only a few series have reported outcomes after treatment with intravenous (IV) recombinant tissue plasminogen activator (rtPA) after mild stroke.
  
  
  OBJECTIVE
  To report treatment complications and short-term outcomes in patients with mild stroke who have received treatment with IV rtPA.
  
  
  METHODS
  Retrospective analysis of patients treated in the emergency department of hospitals that use the Get With the Guidelines-Stroke registry, a prospectively collected quality improvement registry used by hospitals across the United States. Patients were those admitted between May 1, 2010, and October 1, 2012, with acute ischemic stroke within 4.5 hours from symptom onset and a baseline National Institutes of Health Stroke Scale score of 5 or less. Univariable and multivariable analyses were performed to identify factors independently associated with discharge outcomes and treatment complications.
  
  
  METHODS
  Intravenous rtPA.
  
  
  METHODS
  Treatment complications included symptomatic intracranial hemorrhage, life-threatening or serious systemic hemorrhage, other serious complications, and undetermined complications. The short-term outcomes analyzed were in-hospital mortality, discharge to home, independent ambulation at discharge, and length of stay.
  
  
  RESULTS
  Among 33,995 patients who arrived within 4.5 hours of symptom onset and were treated with IV rtPA, 7621 (22.4%) had a National Institutes of Health Stroke Scale score of 5 or less and 5910 had complete data for analysis. Treatment complications were infrequent: symptomatic intracranial hemorrhage, 1.8%; life-threatening or serious systemic hemorrhage, 0.2%; other serious complications, 1.8%; and complications of undetermined cause, 2.4%. Mortality was low (1.3%), but at discharge 30.3% could not ambulate independently, 29.4% could not go directly home, and 73.0% had a length of stay of 3 days or longer. Worse short-term outcomes were seen in older patients, African American patients, diabetic patients, and those who arrived by ambulance, after hours, or with a higher National Institutes of Health Stroke Scale score.
  
  
  CONCLUSIONS
  Many patients with ischemic stroke treated with IV rtPA have a mild stroke. Symptomatic intracranial hemorrhage is infrequent, but approximately 30% of these patients are unable to return directly home or ambulate independently at discharge. Additional studies are needed to identify strategies to improve the outcomes in patients with mild stroke who receive thrombolysis.
authors: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors: Jose G
authors: JG
authors: Romano
authors: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors: Eric E
authors: EE
authors: Smith
authors: Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.
authors: Li
authors: L
authors: Liang
authors: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors: Hannah
authors: H
authors: Gardener
authors: American Heart Association, Dallas, Texas.
authors: Sara
authors: S
authors: Camp
authors: American Heart Association, Dallas, Texas.
authors: Laura
authors: L
authors: Shuey
authors: American Heart Association, Dallas, Texas.
authors: Alison
authors: A
authors: Cook
authors: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors: Iszet
authors: I
authors: Campo-Bustillo
authors: Department of Neurology, University of Cincinnati, Cincinnati, Ohio.
authors: Pooja
authors: P
authors: Khatri
authors: Department of Medicine, Brigham and Women's Hospital Heart & Vascular Center/Harvard Medical School, Boston, Massachusetts.
authors: Deepak L
authors: DL
authors: Bhatt
authors: Department of Medicine, University of California, Los Angeles.
authors: Gregg C
authors: GC
authors: Fonarow
authors: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida.
authors: Ralph L
authors: RL
authors: Sacco
authors: Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston.
authors: Lee H
authors: LH
authors: Schwamm
mesh_terms: D061605:Administration, Intravenous / Q000379:methods; D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000592:standards*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator