title: Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.
abstract: A-kinase anchoring proteins (AKAPs) have emerged as a converging point of diverse signals to achieve spatiotemporal resolution of directed cellular regulation. With the extensive studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre on the mechanism and functional role of synergistic regulation of ion channels by such signalling proteins. In this review, we summarize recent discoveries of AKAP79/150-mediated modulation of voltage-gated neuronal M-type (KCNQ, Kv7) K(+) channels and L-type CaV 1 Ca(2+) channels, on both short- and longer-term time scales, highlighting the dynamics of the macromolecular signalling complexes in brain and peripheral nerve We also discuss several models for the possible mechanisms of these multi-protein assemblies and how they serve the agenda of the neurons in which they occur.
authors: Department of Physiology, University of Texas Health Science Centre at San Antonio, San Antonio, TX, USA.
authors: Jie
authors: J
authors: Zhang
authors: Department of Physiology, University of Texas Health Science Centre at San Antonio, San Antonio, TX, USA.
authors: Mark S
authors: MS
authors: Shapiro
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D006801:Humans; D051656:KCNQ Potassium Channels / Q000378:metabolism; D010525:Peripheral Nerves / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D054758:A Kinase Anchor Proteins; D020746:Calcium Channels, L-Type; D051656:KCNQ Potassium Channels
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