title: Effect of Tai Chi on mononuclear cell functions in patients with non-small cell lung cancer.
abstract: BACKGROUND
  Tai Chi is the Chinese traditional medicine exercise for mind-body health. The objective of this study is to investigate the effect of Tai Chi Chuan (TCC) exercise on the proliferative and cytolytic/tumoricidal activities of peripheral blood mononuclear cells (PBMCs) in postsurgical non-small cell lung cancer (NSCLC) patients.
  
  
  METHODS
  Patients (n = 27) were randomly divided into the control group (n = 13) and the TCC group (n = 14). TCC group participated in Tai Chi 24-type exercise for 16 weeks, 60-min every time, and three times a week. Peripheral blood was collected and PBMCs isolated before and after the 16-week TCC, PBMC proliferation and co-culture of PBMCs with the NSCLC cell line A549 were performed for proliferation and cell cytolysis assays. Analysis of NKT cells, NK cells, and CD123+ and CD11c + dendritic cells were also performed.
  
  
  RESULTS
  (1) After 16-week of TCC, cell proliferation increased significantly as compared with the control. (2) PBMCs from the TCC group also demonstrated enhanced cytolytic/oncolytic activity against A549 cells. (3) Significant differences were also found in NK cell percentage at t = 16 weeks, post-pre changes of NKT and DC11c between groups.
  
  
  CONCLUSIONS
  Regular Tai Chi exercise has the promise of enhancing PBMC proliferative and cytolytic activities in NSCLC patients. Our results affirm the value of a future trial with a larger scale and longer duration for cancer survivors.
  
  
  BACKGROUND
  ChiCTR-TRC-11001404 .
authors: Department of Martial Arts, Shanghai University of Sport, Shanghai, 200438, China. liujing_j3@163.com.|Department of Psychology, School of Kinesiology, University of Michigan, Ann Arbor, MI, 48109, USA. liujing_j3@163.com.
authors: Jing
authors: J
authors: Liu
authors: Department of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. chengpjk@online.sh.cn.
authors: Peijie
authors: P
authors: Chen
authors: Department of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. wangru0612@163.com.
authors: Ru
authors: R
authors: Wang
authors: Department of Sports Leisure, Shanghai University of Sport, Shanghai, 200438, China. yuanyonghong@hotmail.com.
authors: Yonghong
authors: Y
authors: Yuan
authors: Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. xwang@hotmail.com.
authors: Xueqiang
authors: X
authors: Wang
authors: Department of Biochemistry & Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield, 5312 Scott, Detroit, Michigan, 48201, USA. cl@med.wayne.edu.
authors: Chunying
authors: C
authors: Li
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000628:therapy*; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000378:metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D017741:Survivors; D026302:Tai Ji; D013997:Time Factors
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