title: Orthostatic hypotension in a cohort of hypertensive patients referring to a hypertension clinic.
abstract: The prevalence of orthostatic hypotension (OH) in hypertensive patients ranges from 3 to 26%. Drugs are a common cause of non-neurogenic OH. In the present study, we retrospectively evaluated the medical records of 9242 patients with essential hypertension referred to our Hypertension Unit. We analysed data on supine and standing blood pressure values, age, sex, severity of hypertension and therapeutic associations of drugs, commonly used in the treatment of hypertension. OH was present in 957 patients (10.4%). Drug combinations including α-blockers, centrally acting drugs, non-dihydropyridine calcium-channel blockers and diuretics were associated with OH. These pharmacological associations must be administered with caution, especially in hypertensive patients at high risk of OH (elderly or with severe and uncontrolled hypertension). Angiotensin-receptor blocker (ARB) seems to be not related with OH and may have a potential protective effect on the development of OH.
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: C
authors: C
authors: Di Stefano
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: V
authors: V
authors: Milazzo
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: S
authors: S
authors: Totaro
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: G
authors: G
authors: Sobrero
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: A
authors: A
authors: Ravera
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: A
authors: A
authors: Milan
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: S
authors: S
authors: Maule
authors: Autonomic Unit and Hypertension Unit, Department of Medical Sciences, University of Turin, Città della Salute e della Scienza, Turin, Italy.
authors: F
authors: F
authors: Veglio
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D015220:Calcium Channels / Q000009:adverse effects / Q000627:therapeutic use; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D007024:Hypotension, Orthostatic / Q000139:chemically induced / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012017:Referral and Consultation; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D015220:Calcium Channels; D004232:Diuretics
references: J Int Med Res. 2002 Nov-Dec;30(6):543-52
references: 12526280
references: J Intern Med. 2004 Apr;255(4):486-93
references: 15049883
references: Arch Intern Med. 1995 May 8;155(9):930-5
references: 7726701
references: J Clin Hypertens (Greenwich). 2005 Dec;7(12):757-62
references: 16330901
references: Hypertension. 1992 Jun;19(6 Pt 1):508-19
references: 1592445
references: Circulation. 2002 Apr 9;105(14):1669-71
references: 11940545
references: J Am Geriatr Soc. 1991 Jun;39(6):562-6
references: 2037745
references: Diabetes Care. 2009 Jan;32(1):69-74
references: 18852335
references: Clin Ther. 1997 Jul-Aug;19(4):730-42
references: 9377617
references: Am Heart J. 1989 Jan;117(1):256-61
references: 2643285
references: J Hypertens. 2009 May;27(5):976-82
references: 19402222
references: Curr Med Res Opin. 2001;17(4):290-7
references: 11922403
references: Int J Cardiol. 2000 Sep 15;75(2-3):197-204
references: 11077134
references: Am J Hypertens. 2000 Jun;13(6 Pt 1):571-8
references: 10912737
references: Am J Hypertens. 2010 Aug;23(8):817
references: 20644529
references: J Am Geriatr Soc. 1991 Nov;39(11):1057-64
references: 1753042
references: Clin Ther. 1996 Sep-Oct;18(5):797-810
references: 8930424
references: Arch Intern Med. 1999 Feb 8;159(3):273-80
references: 9989539
references: Hypertension. 2010 Dec;56(6):1054-9
references: 21060003
references: Am J Hypertens. 1996 Mar;9(3):263-8
references: 8695026
references: Am J Hypertens. 2011 Feb;24(2):135-44
references: 20814408
references: J Clin Pharm Ther. 2005 Apr;30(2):173-8
references: 15811171
references: J Hypertens. 2013 Jul;31(7):1281-357
references: 23817082
references: Hypertension. 2010 Jul;56(1):56-61
references: 20458003
references: JAMA. 1997 Apr 23-30;277(16):1299-304
references: 9109468
references: Postgrad Med J. 1994 Dec;70(830):878-81
references: 7870633
references: Clin Auton Res. 2009 Feb;19(1):58-64
references: 19199088
references: J Am Geriatr Soc. 2008 Oct;56(10):1816-20
references: 18795982
references: Eur Heart J. 2010 Jan;31(1):85-91
references: 19696189
references: Age Ageing. 2010 Jan;39(1):51-6
references: 19897539
references: Arch Intern Med. 1999 Jun 28;159(12):1350-6
references: 10386511
references: Circulation. 2006 Aug 15;114(7):630-6
references: 16894039
references: Aten Primaria. 2001 Jul-Aug;28(3):151-7
references: 11459520