title: Effect and Placental Transfer of Dexmedetomidine During Caesarean Section Under General Anaesthesia.
abstract: Many drugs can pass through the placenta and cause adverse effects on the foetus. Thus, during Caesarean section for puerperas who have contraindications for intravertebral anaesthesia, the use of proper drugs that have sedative, analgesic effects on the puerperas without adverse effects on the foetus is important. In this study, we investigated the effect and placental transfer of dexmedetomidine during Caesarean section under general anaesthesia. Thirty-eight puerperas were randomly divided to receive dexmedetomidine or saline before anaesthesia induction and during the operation. The dexmedetomidine-treated parturients had lower mean arterial pressure and heart rate at the delivery and at the end of the operation. The dexmedetomidine-treated parturients also needed 5.5% less propofol and 8.4% less fentanyl than the saline-treated ones. Between the dexmedetomidine-treated and saline-treated parturients, there was no difference in the maternal artery, umbilical vein, umbilical artery blood gas analysis results and the Apgar scores at 1 and 5 min. after delivery. The placental transfer rate of dexmedetomidine was 0.76. We concluded that dexmedetomidine was effective in maintaining the haemodynamic stability in the parturients during Caesarean section under general anaesthesia without adverse neonatal effects. Dexmedetomidine can pass through the placenta with a placental transfer rate of 0.76.
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Min
authors: M
authors: Yu
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Chuanbao
authors: C
authors: Han
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Xiuhong
authors: X
authors: Jiang
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Xia
authors: X
authors: Wu
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Li
authors: L
authors: Yu
authors: Department of Anaesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Zhengnian
authors: Z
authors: Ding
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001784:Blood Gas Analysis; D002585:Cesarean Section; D020927:Dexmedetomidine / Q000493:pharmacokinetics* / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics* / Q000494:pharmacology; D010880:Piperidines; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D015742:Propofol; D000077208:Remifentanil; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D010880:Piperidines; D020927:Dexmedetomidine; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol