title: Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line.
abstract: Cordyceps militaris (CM) is gaining attention as a traditional medicinal food, but its molecular biological mechanisms for anti-cancer activity are not identified or clarified. We aimed to elucidate the synthesizing apoptotic effects of CM extracts and to determine the biological effects of CM extract against cordycepin alone in a renal cell carcinoma (RCC) cell line. CM extract showed higher effects of growth inhibition, apoptotic effect, and cell cycle arrest than cordycepin alone. Moreover, CM extract activated extracellular signal-regulated kinase (Erk) highly more than cordycepin alone. We suggest that cordycepin and CM extract induced apoptosis via the activation of Erk dominantly and AMP-activated protein kinase slightly; CM extract has more potent effects on apoptotic effects associated with Erk activation than cordycepin alone.
authors: Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
authors: Kazuhiro
authors: K
authors: Yamamoto
authors: Hiroaki
authors: H
authors: Shichiri
authors: Atsushi
authors: A
authors: Uda
authors: Kazuhiko
authors: K
authors: Yamashita
authors: Tatsuya
authors: T
authors: Nishioka
authors: Manabu
authors: M
authors: Kume
authors: Hiroo
authors: H
authors: Makimoto
authors: Tsutomu
authors: T
authors: Nakagawa
authors: Takeshi
authors: T
authors: Hirano
authors: Midori
authors: M
authors: Hirai
mesh_terms: D055372:AMP-Activated Protein Kinases; D000263:Adenylate Kinase / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D032661:Cordyceps / Q000737:chemistry*; D003839:Deoxyadenosines / Q000494:pharmacology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D003839:Deoxyadenosines; D048049:Extracellular Signal-Regulated MAP Kinases; D055372:AMP-Activated Protein Kinases; D000263:Adenylate Kinase; C058120:cordycepin
keywords: Cordyceps militaris; Erk; RCC; apoptosis