title: Sugar-containing beverage intake in toddlers and body composition up to age 6 years: the Generation R study.
abstract: OBJECTIVE
  Intake of sugar-containing beverages (SCBs) has been associated with higher body mass index (BMI) in childhood. The potential effect of SCB intake during infancy is unclear. We examined the association of SCB intake at 13 months with BMI development until 6 years and body composition at age 6 years.
  
  
  METHODS
  This study included 2371 Dutch children from a population-based prospective cohort study. SCB intake at 13 months was assessed using a Food Frequency Questionnaire with validation against 24-h recalls and was standardized for total energy. BMI was calculated from repeated weight and height measurements, and age- and sex-specific s.d. scores were calculated. Adiposity was measured using Dual-energy X-ray absorptiometry.
  
  
  RESULTS
  In girls, higher SCB intake at 13 months was significantly associated with higher BMI at ages 2, 3, 4 and 6 years (at age 6 years BMI (s.d. score) increase 0.11 (95% confidence interval (CI) +0.00; 0.23), high versus low intake). We observed a tendency towards higher android/gynoid fat ratio in girls with high intake (s.d. increase 0.14 (95% CI -0.02; 0.29), versus low intake) but not with body fat percentage. In boys, there was no association with BMI or body composition, but boys with high SCB intake at 13 months were taller at age 6 years (s.d. increase 0.14 (95% CI +0.00; 0.27), versus low intake).
  
  
  CONCLUSIONS
  Higher SCB intake at 13 months was associated with higher BMI up to age 6 years in girls but not in boys. Our results imply that the unfavorable effects of SCB intake start early in life and that dietary advice regarding limiting SCB intake should already be given early in life.
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: E T M
authors: ET
authors: Leermakers
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [3] Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: J F
authors: JF
authors: Felix
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Department of Biostatistics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: N S
authors: NS
authors: Erler
authors: Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors: A
authors: A
authors: Ćerimagić
authors: 1] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: A I
authors: AI
authors: Wijtzes
authors: Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: A
authors: A
authors: Hofman
authors: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: H
authors: H
authors: Raat
authors: Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: H A
authors: HA
authors: Moll
authors: Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: F
authors: F
authors: Rivadeneira
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [3] Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: V W V
authors: VW
authors: Jaddoe
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors: O H
authors: OH
authors: Franco
authors: 1] Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Leiden University College, The Hague, The Netherlands.
authors: J C
authors: JC
authors: Kiefte-de Jong
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D050154:Adiposity; D001628:Beverages / Q000009:adverse effects*; D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D019422:Dietary Sucrose / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011939:Mental Recall; D063766:Pediatric Obesity / Q000209:etiology* / Q000378:metabolism; D012737:Sex Factors; D011795:Surveys and Questionnaires
chemical_list: D019422:Dietary Sucrose
references: Am J Clin Nutr. 1993 Oct;58(4):489-96
references: 8379504
references: Pediatrics. 2013 Sep;132(3):468-74
references: 23940242
references: J Am Diet Assoc. 2004 Jul;104(7):1086-94
references: 15215766
references: Adv Nutr. 2011 Mar;2(2):182S-200S
references: 22332051
references: J Am Diet Assoc. 2010 Oct;110(10):1477-84
references: 20869486
references: Am J Clin Nutr. 2010 Nov;92(5):1257-64
references: 20861173
references: BMJ. 2000 May 6;320(7244):1240-3
references: 10797032
references: PLoS One. 2013 Oct 22;8(10):e78039
references: 24167595
references: Eur J Nutr. 2015 Mar;54(2):283-90
references: 24806082
references: Obesity (Silver Spring). 2012 Jun;20(6):1313-8
references: 22282048
references: Am J Epidemiol. 1989 Jan;129(1):125-37
references: 2910056
references: Int J Behav Nutr Phys Act. 2009 Oct 26;6:71
references: 19857247
references: J Natl Cancer Inst. 2008 Dec 3;100(23 ):1658-9
references: 19033567
references: Physiol Behav. 2006 Aug 30;89(1):66-70
references: 16516935
references: Obes Rev. 2013 Aug;14(8):606-19
references: 23763695
references: Am J Clin Nutr. 2002 Dec;76(6):1416-21
references: 12450911
references: PLoS One. 2014 Jan 22;9(1):e85769
references: 24465694
references: Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6
references: 12835281
references: Public Health Nutr. 2014 Mar;17 (3):498-509
references: 23632037
references: Int J Obes Relat Metab Disord. 2004 Jan;28(1):10-6
references: 14652621
references: Pediatrics. 2008 Jun;121(6):e1604-14
references: 18519465
references: Eur J Epidemiol. 2012 Sep;27(9):739-56
references: 23086283
references: Eur J Epidemiol. 2004;19(8):769-76
references: 15469034
references: Am J Clin Nutr. 2014 Mar;99(3):663S-91S
references: 24500158
references: J Hum Nutr Diet. 2010 Oct;23 (5):502-10
references: 20163509
references: Stat Med. 1991 Apr;10(4):585-98
references: 2057657
references: Am J Clin Nutr. 1997 Apr;65(4 Suppl):1220S-1228S; discussion 1229S-1231S
references: 9094926
references: N Engl J Med. 2012 Oct 11;367(15):1397-406
references: 22998340
references: N Engl J Med. 2012 Oct 11;367(15):1462-3
references: 22998341
references: Am J Clin Nutr. 2013 Oct;98(4):1084-102
references: 23966427
references: Am J Clin Nutr. 2014 Nov;100(5):1329-36
references: 25332330
references: Br J Nutr. 2013 Jan 14;109 (1):137-47
references: 22475342
references: Int J Obes (Lond). 2014 Jul;38(7):930-5
references: 24509503
references: Appetite. 2010 Aug;55(1):137-46
references: 20546812