title: Association between methylation of SHP-1 isoform I and SSTR2A promoter regions with breast and prostate carcinoma development.
abstract: Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 in breast cancer. We found significant concordances for both cancers and SHP-1(I) unmethylation, and increased HER2 expression and SSTR2A methylation in breast cancer. Moreover, we found a correlation between methylation patterns of two genes in normal breast tissue. These data might assist to select subgroups of patients for the administration of alternative therapies.
authors: Laboratory of Molecular Biotechnology, Faculty of Exact, Chemical and Natural Sciences, National University of Misiones , Posadas, Misiones , Argentina.
authors: María Mercedes
authors: MM
authors: Tiscornia
authors: Heidi Soledad
authors: HS
authors: González
authors: María Angélica
authors: MA
authors: Lorenzati
authors: Pedro Darío
authors: PD
authors: Zapata
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D019175:DNA Methylation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000235:genetics*; D017481:Receptors, Somatostatin / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D020033:Protein Isoforms; D017481:Receptors, Somatostatin; C093733:somatostatin receptor 2; C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6
keywords: Breast cancer; Concordance; Methylation pattern; Prostate cancer; SHP-1(I); SSTR2A