title: In vitro and in vivo anti-MRSA activities of nosokomycins.
abstract: The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.
authors: Graduate School of Pharmaceutical Sciences, Kitasato University.
authors: Ryuji
authors: R
authors: Uchida
authors: Hideaki
authors: H
authors: Hanaki
authors: Hidenori
authors: H
authors: Matsui
authors: Hiroshi
authors: H
authors: Hamamoto
authors: Kazuhisa
authors: K
authors: Sekimizu
authors: Masato
authors: M
authors: Iwatsuki
authors: Yong Pil
authors: YP
authors: Kim
authors: Hiroshi
authors: H
authors: Tomoda
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D012831:Bombyx; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007814:Larva; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D013290:Streptococcal Infections / Q000382:microbiology; D013302:Streptomyces / Q000737:chemistry; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin