title: Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress.
abstract: Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.
authors: School of Biomedical Sciences, The University of Queensland Brisbane, QLD, Australia.
authors: Jereme G
authors: JG
authors: Spiers
authors: School of Biomedical Sciences, The University of Queensland Brisbane, QLD, Australia.
authors: Hsiao-Jou Cortina
authors: HJ
authors: Chen
authors: School of Biomedical Sciences, The University of Queensland Brisbane, QLD, Australia.
authors: Conrad
authors: C
authors: Sernia
authors: School of Biomedical Sciences, The University of Queensland Brisbane, QLD, Australia.
authors: Nickolas A
authors: NA
authors: Lavidis
keywords: corticosterone; hypothalamic-pituitary-adrenal axis; oxidative stress; reactive oxygen species; redox status; stress
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