title: [Clinical characteristics and prognostic analysis of 90 patients with primary gastro-intestinal marginal zone lymphoma].
abstract: OBJECTIVE
  To evaluate the clinical characteristics and prognostic factors of patients with primary gastro-intestinal marginal zone lymphoma (MALT).
  
  
  METHODS
  Retrospective analysis was performed in 90 patients diagnosed with primary gastro-intestinal MALT lymphoma clinical characteristics and survival analyses.
  
  
  RESULTS
  Among 90 patients, 78 cases were originated from the stomach and 12 cases with extra-gastric origin. Eighty patients were classified as low-risk (IPI score 0-2), and 10 patients high-risk (IPI score 3-5). Compared to gastric MALT patients, extra-gastric cases presented with higher IPI score (7.7% vs 33.3%, P=0.025) and higher Hp infection rate (50.0% vs 87.2%, P<0.01). Treatment options for low risk patients (IPI score 0-2) included Hp eradication, surgery, radiotherapy and chemotherapy. Chemotherapy could improve progression-free survival (PFS) in low-risk patients. For high-risk patients, those receiving chemotherapy had 100% 3-year overall survival (OS). Univariate analysis revealed that ECOG (P=0.006), Mussh-off staging (P=0.008), IPI score (P=0.000), elevated LDH (P=0.019) and chemotherapy (P=0.026) were correlated with PFS. Multivariate analysis showed that higher IPI score (IPI 3-5) (OR=8.325, 95% CI 3.171-21.853, P=0.000) and chemotherapy (OR=0.319, 95% CI 0.121-0.838, P=0.020) were independent prognostic factors for PFS. ECOG (≥ 2) was independent prognostic factor for OS (OR=5.092, 95%CI 1.005-25.788, P=0.049).
  
  
  CONCLUSIONS
  Primary gastro-intestinal MALT lymphoma was an indolent subtype of non-Hodgkin's lymphoma. Patients usually had low risk IPI and achieved long-term survival. Frontline therapy for low-risk patients was radiotherapy or Hp eradication, and chemotherapy for high-risk ones.
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Xia
authors: X
authors: Zhao
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Li
authors: L
authors: Wang
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Shengting
authors: S
authors: Zhang
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Shubei
authors: S
authors: Wang
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Yunwei
authors: Y
authors: Sun
authors: Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Shanghai 200025, China.
authors: Weili
authors: W
authors: Zhao
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D007414:Intestinal Neoplasms; D018442:Lymphoma, B-Cell, Marginal Zone; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms; D016019:Survival Analysis
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