title: Dual-functional analogous cis-platinum complex with high antitumor activities and two-photon bioimaging.
abstract: Here we have designed and synthesized a novel analogous cis-platinum complex (TDPt) with strong two-photon absorption properties and higher stability upon laser irradiation. Interestingly, a higher cytotoxicity against three types of cancer cells compared to that of commercial cis-platinum was observed. The initial confocal micrographs showed that lysosomes may be the biological targets of such TDPt, except the conventional presumed DNA. This hypothesis was further confirmed by the two-photon microscopy and transmission electron microscopy micrograph. These results form an important basis for future "on-site observation" of the anticancer mechanism of the Pt(II) complex.
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Qiong
authors: Q
authors: Zhang
authors: ‡Department of Chemistry, The MRC/UCL Centre for Medical Molecular Virology, University College London, London WC1H 0AJ, U.K.
authors: Xiaohe
authors: X
authors: Tian
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Guiju
authors: G
authors: Hu
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Pengfei
authors: P
authors: Shi
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Jieying
authors: J
authors: Wu
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Shengli
authors: S
authors: Li
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Hongping
authors: H
authors: Zhou
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Bao-Kang
authors: BK
authors: Jin
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Jiaxiang
authors: J
authors: Yang
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Shengyi
authors: S
authors: Zhang
authors: †Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors: Yupeng
authors: Y
authors: Tian
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008247:Lysosomes / Q000187:drug effects; D008853:Microscopy / Q000379:methods*; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D017785:Photons; D012545:Schiff Bases / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D012545:Schiff Bases