title: The role of epoxyeicosatrienoic acids in the cardiovascular system.
abstract: There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.
authors: Experimental Medicine and Immunotherapeutics, Department of Medicine, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors: L
authors: L
authors: Yang
authors: Experimental Medicine and Immunotherapeutics, Department of Medicine, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors: K
authors: K
authors: Mäki-Petäjä
authors: Experimental Medicine and Immunotherapeutics, Department of Medicine, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors: J
authors: J
authors: Cheriyan
authors: Experimental Medicine and Immunotherapeutics, Department of Medicine, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors: C
authors: C
authors: McEniery
authors: Experimental Medicine and Immunotherapeutics, Department of Medicine, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
authors: I B
authors: IB
authors: Wilkinson
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D058990:Molecular Targeted Therapy
chemical_list: D006893:Hydroxyeicosatetraenoic Acids
keywords: cardiovascular system; epoxyeicosatrienoic acids; soluble epoxide hydrolase inhibitor; vascular tone
references: Circ Res. 1996 Mar;78(3):415-23
references: 8593700
references: BMC Cancer. 2014;14:841
references: 25406731
references: J Pharmacol Exp Ther. 1983 Sep;226(3):790-5
references: 6411898
references: Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2412-20
references: 15284062
references: J Clin Pharmacol. 2012 Mar;52(3):319-28
references: 21422238
references: J Pharmacol Exp Ther. 2002 Aug;302(2):442-50
references: 12130701
references: Circ Res. 1999 Aug 20;85(4):349-56
references: 10455063
references: Circ Res. 2005 Oct 28;97(9):908-15
references: 16179585
references: Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H64-71
references: 16143653
references: Br J Pharmacol. 1988 Mar;93(3):515-24
references: 2453240
references: Circ Res. 2000 Nov 24;87(11):992-8
references: 11090543
references: Physiol Rev. 2012 Jan;92(1):101-30
references: 22298653
references: J Pharmacol Exp Ther. 2006 Jul;318(1):276-81
references: 16565165
references: Br J Clin Pharmacol. 2001 Dec;52(6):631-46
references: 11736874
references: Clin Sci (Lond). 2003 Oct;105(4):513-8
references: 12826020
references: Prostaglandins. 1977 Jan;13(1):3-15
references: 841106
references: Circulation. 2000 Mar 7;101(9):948-54
references: 10704159
references: Atherosclerosis. 2007 Nov;195(1):199-206
references: 17126841
references: Lancet. 1989 Oct 28;2(8670):997-1000
references: 2572793
references: Lancet. 2009 Jan 24;373(9660):309-17
references: 19108880
references: Hypertension. 2011 Jan;57(1):116-22
references: 21098312
references: Br J Pharmacol. 2011 Nov;164 Suppl 1:S1-324
references: 22040146
references: Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1495-502
references: 16675722
references: J Vasc Res. 1999 Sep-Oct;36(5):385-92
references: 10559679
references: Drug Metab Dispos. 2010 Dec;38(12):2252-8
references: 20736321
references: Am J Respir Crit Care Med. 2001 Aug 15;164(4):709-13
references: 11520741
references: J Biol Chem. 2001 Jul 6;276(27):25467-79
references: 11328810
references: Nature. 1999 Sep 30;401(6752):493-7
references: 10519554
references: J Med Chem. 2009 Aug 27;52(16):5069-75
references: 19653681
references: Atherosclerosis. 2012 Jun;222(2):530-6
references: 22503544
references: J Pharmacol Exp Ther. 1987 Mar;240(3):856-63
references: 3104582
references: Circulation. 2005 Jan 4;111(1):63-9
references: 15611369
references: Circ Res. 1998 Nov 2;83(9):932-9
references: 9797342
references: Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11127-32
references: 25024195
references: Curr Drug Metab. 2008 Sep;9(7):661-7
references: 18781916
references: Nature. 1998 Nov 19;396(6708):269-72
references: 9834033
references: Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):168-75
references: 12588755
references: Mol Pharmacol. 1999 Feb;55(2):288-95
references: 9927620
references: Am J Respir Cell Mol Biol. 2012 May;46(5):614-22
references: 22180869
references: Br J Pharmacol. 2000 Mar;129(6):1145-54
references: 10725263
references: Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1982-8
references: 18790831
references: Hum Mol Genet. 2005 Oct 1;14(19):2829-37
references: 16115816
references: Eur J Pharmacol. 2011 Mar 1;654(1):68-74
references: 21187082
references: Circulation. 2004 Oct 12;110(15):2132-6
references: 15466638
references: Lipids Health Dis. 2013;12:151
references: 24148690
references: Circulation. 2012 Mar 13;125(10):1266-75
references: 22412088
references: Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1096-102
references: 19617407
references: J Pharmacol Exp Ther. 1983 Sep;226(3):796-801
references: 6411899
references: Science. 2012 May 4;336(6081):597-601
references: 22556255
references: Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1307-17
references: 21832210
references: J Cereb Blood Flow Metab. 2007 Dec;27(12):1931-40
references: 17440491
references: J Pharmacol Exp Ther. 1982 Jul;222(1):166-73
references: 6806467
references: Cancer Metastasis Rev. 2011 Dec;30(3-4):525-40
references: 22009066
references: Biochem Biophys Res Commun. 1999 Feb 16;255(2):300-6
references: 10049703
references: Hypertension. 1999 Dec;34(6):1242-6
references: 10601125
references: Pharmacol Res. 2004 Jun;49(6):551-64
references: 15026033
references: Prostaglandins Other Lipid Mediat. 2000 Oct;62(4):321-33
references: 11060896
references: Hypertension. 2012 Dec;60(6):1415-21
references: 23090775
references: Arch Biochem Biophys. 2009 Sep;489(1-2):82-91
references: 19464254
references: Mol Pharmacol. 1996 Nov;50(5):1111-7
references: 8913342
references: Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H358-64
references: 15331373
references: Circulation. 2004 Jan 27;109(3):335-9
references: 14732757
references: Circulation. 2008 Feb 26;117(8):1065-74
references: 18268148
references: J Lipid Mediat Cell Signal. 1997 Jul;16(3):155-69
references: 9246605
references: Diabetes Care. 1999 Jun;22(6):973-81
references: 10372251
references: Mol Pharmacol. 2003 Aug;64(2):482-90
references: 12869654
references: Stroke. 2008 May;39(5):1593-6
references: 18323494
references: Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31
references: 23434473
references: Clin Sci (Lond). 2012 Jun;122(11):513-25
references: 22324471
references: Atherosclerosis. 2007 Jan;190(1):26-34
references: 16545818
references: J Physiol. 1998 Apr 15;508 ( Pt 2):561-73
references: 9508817
references: Am J Pathol. 2009 Jun;174(6):2086-95
references: 19435785
references: Nature. 2003 Jul 24;424(6947):434-8
references: 12879072
references: Fed Proc. 1979 Jan;38(1):66-71
references: 215463
references: Circulation. 2011 May 24;123(20):2244-53
references: 21555712
references: Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H517-31
references: 16617127
references: Atherosclerosis. 2013 Apr;227(2):442-8
references: 23466098
references: Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):60-7
references: 17164133
references: Nature. 1980 Nov 27;288(5789):373-6
references: 6253831
references: J Vasc Res. 2014;51(3):200-8
references: 24925526
references: Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1936-42
references: 12384472
references: Biochemistry. 2011 May 10;50(18):3840-8
references: 21469660
references: Hypertension. 2008 May;51(5):1379-85
references: 18378855
references: Exp Clin Endocrinol Diabetes. 2010 Jun;118(6):346-52
references: 20140850
references: Pharmacogenet Genomics. 2010 Feb;20(2):94-103
references: 20065888
references: Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H232-40
references: 11406490
references: Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E500-9
references: 22185841
references: Proc Natl Acad Sci U S A. 1990 Aug;87(15):5893-7
references: 2198572
references: Circulation. 2004 Oct 5;110(14):1926-32
references: 15451794
references: Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):50-61
references: 17259072
references: J Biol Chem. 1996 Feb 16;271(7):3460-8
references: 8631948
references: Circulation. 2002 Mar 5;105(9):1135-43
references: 11877368
references: J Lipid Res. 1998 Aug;39(8):1713-21
references: 9717733
references: Circulation. 2011 Apr 12;123(14):1545-51
references: 21444885
references: J Pharmacol Exp Ther. 2008 Mar;324(3):1019-27
references: 18171909
references: Circ Res. 2002 Apr 19;90(7):800-6
references: 11964373
references: Pharmacol Ther. 2011 Jul;131(1):1-17
references: 21514320
references: Prog Lipid Res. 2005 Jan;44(1):1-51
references: 15748653
references: Clin Chim Acta. 2004 Oct;348(1-2):57-61
references: 15369736
references: Proc Natl Acad Sci U S A. 2007 May 22;104(21):9018-23
references: 17495027
references: J Vasc Res. 2000 Sep-Oct;37(5):426-34
references: 11025406
references: Thorax. 2011 Jul;66(7):585-90
references: 21515553
references: Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C278-90
references: 22621785
references: Exp Diabetes Res. 2012;2012:758614
references: 22007192
references: J Pharmacol Exp Ther. 2009 Jun;329(3):908-18
references: 19289568
references: Am J Physiol. 1991 Sep;261(3 Pt 2):H843-52
references: 1887929
references: Am J Physiol Renal Physiol. 2000 Sep;279(3):F544-51
references: 10966934
references: Cancer Res. 2007 Jul 15;67(14):6665-74
references: 17638876
references: J Physiol. 1994 Dec 1;481 ( Pt 2):407-14
references: 7738833
references: J Am Coll Cardiol. 2006 Aug 1;48(3):508-15
references: 16875977
references: J Cardiovasc Pharmacol. 2008 Oct;52(4):314-23
references: 18791465
references: Cardiovasc Res. 2010 Jan 1;85(1):232-40
references: 19679679
references: Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):54-60
references: 18927469
references: Circulation. 2002 Mar 19;105(11):1323-8
references: 11901043
references: Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2612-8
references: 17872452
references: Circ Res. 2001 Jan 19;88(1):44-51
references: 11139472
references: J Cereb Blood Flow Metab. 2013 Oct;33(10):1650-6
references: 23899929
references: Circulation. 2003 Feb 11;107(5):769-76
references: 12578883
references: J Breath Res. 2012 Jun;6(2):026001
references: 22451217
references: Vascul Pharmacol. 2012 Sep-Oct;57(2-4):113-8
references: 22609132
references: J Physiol. 1998 May 1;508 ( Pt 3):777-92
references: 9518732
references: Cardiovasc Res. 2008 Dec 1;80(3):445-52
references: 18682435
references: Annu Rev Pharmacol Toxicol. 2005;45:311-33
references: 15822179
references: Trends Pharmacol Sci. 2000 Apr;21(4):121-4
references: 10740282
references: J Biol Chem. 1997 May 9;272(19):12551-9
references: 9139707
references: J Hypertens. 2013 Feb;31(2):321-32
references: 23307303
references: J Pharmacol Exp Ther. 2009 Dec;331(3):906-16
references: 19717790
references: Z Kardiol. 2000;89 Suppl 9:IX/70-4
references: 11151799
references: J Am Soc Nephrol. 1996 Nov;7(11):2364-70
references: 8959626
references: Biochem Biophys Res Commun. 1983 Jul 29;114(2):743-9
references: 6411091
references: Prostaglandins Other Lipid Mediat. 2000 Aug;62(3):271-92
references: 10963794
references: Hypertension. 2009 Mar;53(3):532-8
references: 19188524
references: J Biol Chem. 1999 Jun 18;274(25):17777-88
references: 10364221
references: Circ Res. 1997 Aug;81(2):258-67
references: 9242187
references: J Cardiovasc Pharmacol. 1996 Nov;28(5):703-11
references: 8945685
references: Blood Press. 2011 Jun;20(3):166-70
references: 21332417
references: J Biol Chem. 1998 Nov 20;273(47):31581-9
references: 9813074
references: Kidney Blood Press Res. 2012;35(6):595-607
references: 22948718
references: Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):42-9
references: 17164131
references: J Pharmacol Exp Ther. 2007 Jun;321(3):1023-31
references: 17327488
references: J Pharmacol Exp Ther. 2010 Aug;334(2):430-8
references: 20439437
references: Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2470-7
references: 11356600
references: J Physiol. 2003 Jan 1;546(Pt 1):307-14
references: 12509498
references: Hum Mol Genet. 2006 May 15;15(10):1640-9
references: 16595607
references: Front Physiol. 2010 Dec 03;1:157
references: 21423396
references: J Hypertens. 2011 Jun;29(6):1128-35
references: 21451419
references: Pharmacol Ther. 2014 Nov;144(2):134-61
references: 24882266
references: Circ J. 2006 Jan;70(1):49-56
references: 16377924
references: Circulation. 2002 Aug 6;106(6):653-8
references: 12163423
references: Proc Natl Acad Sci U S A. 2011 May 31;108(22):9038-43
references: 21571638
references: Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H724-35
references: 18055514
references: Prog Lipid Res. 2004 Jan;43(1):55-90
references: 14636671
references: J Cardiovasc Pharmacol. 1998 Oct;32(4):642-9
references: 9781934
references: Stroke. 2008 Jul;39(7):2073-8
references: 18369166
references: Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2430-40
references: 11356595
references: Am J Respir Crit Care Med. 2007 Jun 15;175(12):1259-65
references: 17363772
references: Circulation. 2004 Jan 20;109(2):178-83
references: 14662709
references: Endocrinology. 1997 Mar;138(3):1338-46
references: 9048644
references: Circ Res. 1997 Jun;80(6):877-84
references: 9168791
references: Br J Pharmacol. 2000 Jun;130(3):549-56
references: 10821782
references: Pulm Pharmacol Ther. 2012 Feb;25(1):69-76
references: 22155000
references: Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R188-96
references: 15345471
references: Indian J Exp Biol. 2007 Jun;45(6):505-14
references: 17585684
references: J Biol Chem. 2001 May 11;276(19):15983-9
references: 11279071
references: Science. 1999 Aug 20;285(5431):1276-9
references: 10455056
references: Am J Respir Crit Care Med. 2009 Sep 15;180(6):513-20
references: 19542477
references: Clin Sci (Lond). 2014 Oct;127(7):463-74
references: 24707975