title: Emergence of a new lineage of dengue virus type 2 identified in travelers entering Western Australia from Indonesia, 2010-2012.
abstract: Dengue virus (DENV) transmission is ubiquitous throughout the tropics. More than 70% of the current global dengue disease burden is borne by people who live in the Asia-Pacific region. We sequenced the E gene of DENV isolated from travellers entering Western Australia between 2010-2012, most of whom visited Indonesia, and identified a diverse array of DENV1-4, including multiple co-circulating viral lineages. Most viruses were closely related to lineages known to have circulated in Indonesia for some time, indicating that this geographic region serves as a major hub for dengue genetic diversity. Most notably, we identified a new lineage of DENV-2 (Cosmopolitan genotype) that emerged in Bali in 2011-2012. The spread of this lineage should clearly be monitored. Surveillance of symptomatic returned travellers provides important and timely information on circulating DENV serotypes and genotypes, and can reveal the herald wave of dengue and other emerging infectious diseases.
authors: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
authors: Timo
authors: T
authors: Ernst
authors: PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
authors: Suzi
authors: S
authors: McCarthy
authors: PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
authors: Glenys
authors: G
authors: Chidlow
authors: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
authors: Dagwin
authors: D
authors: Luang-Suarkia
authors: Marie Bashir Institute for Emerging Diseases & Biosecurity, Charles Perkins Centre, School of Biological Sciences and Medical School, The University of Sydney, Sydney, New South Wales, Australia.
authors: Edward C
authors: EC
authors: Holmes
authors: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
authors: David W
authors: DW
authors: Smith
authors: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
authors: Allison
authors: A
authors: Imrie
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D003715:Dengue / Q000453:epidemiology / Q000821:virology*; D003716:Dengue Virus / Q000235:genetics*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D014709:Vero Cells; D014904:Western Australia / Q000453:epidemiology
chemical_list: D012367:RNA, Viral
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