title: Associations between TRPV4 genotypes and body mass index in Taiwanese subjects.
abstract: Body weight regulation is influenced neuronally via the hypothalamus, which strongly expresses TRPV4. TRPV4 deficiency in mice confers resistance against diet-induced obesity. We investigated the association between TRPV4 gene variants and body mass index (BMI) in Taiwanese subjects. A sample population of 617 Taiwanese subjects was enrolled, and ten TRPV4 gene polymorphisms were selected and genotyped. After adjusting for clinical covariates, significant associations were observed between three studied polymorphisms and BMI using a dominant model (P = 4.83 × 10(-4), P = 1.17 × 10(-4), and P = 3.37 × 10(-4) for rs3742037, rs10735104, and rs3742035, respectively). Obesity as defined according to both the Asian and National Institutes of Health (NIH) criteria was significantly associated with rs10735104 (P = 0.003 and P = 0.037, respectively) in a dominant model. Genotypes at the TRPV4 locus independently affect BMI and obesity status in Taiwanese subjects. This association may broaden our understanding of the role of neuronal influence on body weight regulation. The regulation of TRPV4 channels in skeletal muscle and adipose tissue could also be a new therapeutic target for preventing the development of obesity.
authors: Division of Cardiology, Department of Internal Medicine and The Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289 Jianguo Road, Xindian Dist, New Taipei City, 231, Taiwan, ROC.
authors: De-Min
authors: DM
authors: Duan
authors: Semon
authors: S
authors: Wu
authors: Lung-An
authors: LA
authors: Hsu
authors: Ming-Sheng
authors: MS
authors: Teng
authors: Jeng-Feng
authors: JF
authors: Lin
authors: Yu-Chen
authors: YC
authors: Sun
authors: Ching-Feng
authors: CF
authors: Cheng
authors: Yu-Lin
authors: YL
authors: Ko
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D050916:TRPV Cation Channels / Q000235:genetics*; D013624:Taiwan; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol
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