title: Compensatory cognitive training for people with first-episode schizophrenia: results from a pilot randomized controlled trial.
abstract: Cognitive training or remediation now has multiple studies and meta-analyses supporting its efficacy in improving cognition and functioning in people with schizophrenia. However, relatively little is known about cognitive training outcomes in early psychosis. We conducted a pilot randomized controlled trial of Compensatory Cognitive Training (CCT) compared to Treatment as Usual (TAU) in 27 participants with first-episode psychosis who had received treatment for psychosis for less than six months. Assessments of cognition (MATRICS Consensus Cognitive Battery; MCCB) and functional capacity (UCSD Performance-Based Skills Assessment-Brief; UPSA-B) were administered at baseline and following the 12-week treatment. The CCT condition, compared to TAU, was associated with significant improvements on the MCCB composite score, as well as MCCB subtests measuring processing speed (Trail Making) and social cognition (Mayer-Salovey-Caruso Emotional Intelligence Test), with large effects on these three outcome measures. There were no significant CCT-associated effects on the UPSA-B or on positive, negative, or depressive symptoms. CCT treatment of cognitive impairments in first-episode schizophrenia is feasible and can result in large effect size improvements in global cognition, processing speed, and social cognition.
authors: Ricci & Associates, 1101 Prince of Wales Drive, Suite 110, Ottawa, ON K2C 3W7, Canada.
authors: Paul D
authors: PD
authors: Mendella
authors: San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, 140 Arbor Drive (0851), San Diego, CA 92103, United States.
authors: Cynthia Z
authors: CZ
authors: Burton
authors: The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1G 0H9, Canada; University of Ottawa, 65 Laurier Avenue East, Ottawa, ON K1N 6N5, Canada.
authors: Giorgio A
authors: GA
authors: Tasca
authors: Ricci & Associates, 1101 Prince of Wales Drive, Suite 110, Ottawa, ON K2C 3W7, Canada.
authors: Paul
authors: P
authors: Roy
authors: The Ottawa Hospital, 501 Smyth Road, Ottawa, ON K1G 0H9, Canada.
authors: Lea
authors: L
authors: St Louis
authors: University of California, San Diego, Department of Psychiatry, United States; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, United States. Electronic address: etwamley@ucsd.edu.
authors: Elizabeth W
authors: EW
authors: Twamley
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000628:therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cognition; Cognitive remediation; Functional capacity; Psychosis; Social cognition