title: Comparison of the effects of fetal hypothyroidism on glucose tolerance in male and female rat offspring.
abstract: Thyroid hormones are vital for survival of mammalian species and play critical roles in growth, development, and metabolism. Both fetal hypothyroidism and sex can affect carbohydrate metabolism during adult life. This study aims to assess carbohydrate metabolism in male and female offspring born from mothers who were hypothyroid during pregnancy. Pregnant rats were divided into two groups; the controls consumed water and the hypothyroid group received water containing 0.025 % 6-propyl-2-thiouracial throughout gestation. The intravenous glucose tolerance test (0.5 g/kg glucose) was carried out in 3-month-old offspring. Findings showed that compared to controls, male fetal hypothyroid rats during adulthood had glucose intolerance (area under the curve: 446.4 ± 9.7 vs. 486.4 ± 8.8, p < 0.01 in control and fetal hypothyroid groups, respectively) whereas females had improved glucose tolerance (478.1 ± 7.0 vs. 455.9 ± 8.5, p < 0.01). In conclusion, sex could modulate the effects of fetal hypothyroidism on glucose tolerance in rats.
authors: Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Parvaneh Street, Velenjak, Tehran, Iran.
authors: Fatemeh
authors: F
authors: Bagheripuor
authors: Mahboubeh
authors: M
authors: Ghanbari
authors: Saleh
authors: S
authors: Zahediasl
authors: Asghar
authors: A
authors: Ghasemi
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism* / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000378:metabolism / Q000503:physiopathology; D005951:Glucose Tolerance Test / Q000379:methods; D007037:Hypothyroidism / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D005947:Glucose
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