title: Protective effects of vitamin E against liver damage caused by renal ischemia reperfusion.
abstract: Recent studies have reported that remote organs are affected by renal ischemia reperfusion (IR). The present study investigates the role of vitamin E on the liver damage after renal IR. First, male mice were subjected to three groups (n = 9): 1) sham-operated, (2) renal IR (45 min ischemia), (3) renal IR + Vitamin E (150 mg/kg trough feeding tube for 28 d). After 24 h of reperfusion, animal were anesthetized for sample collections. Liver tissues malondialdehyde (MDA) increased and total glutathione (GSH) concentration decreased in the IR group compared to the sham group. Vitamin E consumption diminished the IR-induced increase in plasma AST and ALT. In addition, Vitamin E inhibited the IR-induced decrease in GSH activity and diminished IR-induced increase in MDA concentration. These findings showed that vitamin E consumption partly inhibited the IR-induced liver damage.
authors: School of Medicine, Shahroud University of Medical Sciences , Shahroud , Iran.
authors: Hossein
authors: H
authors: Khastar
mesh_terms: D000123:Acetyltransferases / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D019610:Cytoprotection; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000209:etiology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D015427:Reperfusion Injury / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000378:metabolism; D016896:Treatment Outcome; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000123:Acetyltransferases; D000410:Alanine Transaminase; D005978:Glutathione
keywords: Liver damage; remote organs; renal ischemia; reperfusion; vitamin E