title: [The effectiveness of corneal cross-linking in stopping the progression of keratoconus].
abstract: OBJECTIVE
  Objective of the study was to prove the efficiency of corneal cross-linking (CXL) in stopping the progression of keratoconus.
  
  
  METHODS
  In this study were included 58 eyes of patients with progressive keratoconus who underwent CXL according to the Dresden protocol in the years 2007-2009 at the Ophthalmic clinic FN Brno Bohunice. The eyes of patients were divided into four groups according to the change of maximum curvature of the cornea two years after CXL.
  
  
  RESULTS
  Stabilization of maximum curvature of the cornea have been reported in 40 % of eyes, regression in 57 % of eyes by an average of 1,92D and disease progression in 3 % of eyes 2 years after CXL. The eyes with regression over 2D had significantly higher best-corrected visual acuity before and after the procedure compared to the group with stabilization. Spherical equivalent increased significantly in all groups, on average, in the group with stabilization of 0,54D, in the group with mild regression of 0,71D and in the group with a large regression of 2,09D. In the group with a large regression 100 % of eyes had stabilization or increase in SE. Our observations showed that, when a decrease in the patient keratometric values of cornea is present after CXL, it is comprehensive and applies to all parameters.
  
  
  CONCLUSIONS
  We have confirmed that corneal cross-linking stops the progression of the disease in 97 % of eyes two years after the procedure.
authors: E
authors: E
authors: Strmeňová
authors: E
authors: E
authors: Vlková
authors: L
authors: L
authors: Michalcová
authors: V
authors: V
authors: Trnková
authors: D
authors: D
authors: Dvořáková
authors: M
authors: M
authors: Goutaib
authors: J
authors: J
authors: Němec
authors: A
authors: A
authors: Gerinec
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000627:therapeutic use*; D019781:Corneal Topography; D003432:Cross-Linking Reagents; D018450:Disease Progression; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012189:Retrospective Studies; D012256:Riboflavin / Q000627:therapeutic use*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin