title: A ruthenium(II) complex as turn-on Cu(II) luminescent sensor based on oxidative cyclization mechanism and its application in vivo.
abstract: Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this paper, a novel water-soluble ruthenium(II) complex as a turn-on copper(II) ions luminescent sensor based on o-(phenylazo)aniline was designed and synthesized. The azo group would undergo a specific oxidative cyclization reaction with copper(II) ions and turn into high luminescent benzotriazole, triggering significant luminescent increasements which were linear to the concentrations of copper(II) ions. The sensor distinguished by its high sensitivity (over 80-fold luminescent switch-on response), good selectivity (the changes of the emission intensity in the presence of other metal ions or amino acids were negligible) and low detection limit (4.42 nM) in water. Moreover, the copper(II) luminescent sensor exhibited good photostability under light irradiation. Furthermore, the applicability of the proposed sensor in biological samples assay was also studied and imaged copper(II) ions in living pea aphids successfully.
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Yunfei
authors: Y
authors: Zhang
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Zonglun
authors: Z
authors: Liu
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Kui
authors: K
authors: Yang
authors: College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China.
authors: Yi
authors: Y
authors: Zhang
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Yongqian
authors: Y
authors: Xu
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Hongjuan
authors: H
authors: Li
authors: Key Laboratory of Eco-Textile, Ministry of Education, School of Textile and Clothing, Jiangnan University, 1800 Lihu Avenue Wuxi, 214122, China.
authors: Chaoxia
authors: C
authors: Wang
authors: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
authors: Aiping
authors: A
authors: Lu
authors: College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors: Shiguo
authors: S
authors: Sun
mesh_terms: D000818:Animals; D001042:Aphids / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D003500:Cyclization; D008163:Luminescent Measurements; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D014230:Triazoles; D003300:Copper; D012428:Ruthenium; C012771:benzotriazole
references: Chemosphere. 2006 Dec;65(11):2114-21
references: 16875712
references: Anal Chem. 2002 Feb 1;74(3):547-50
references: 11838674
references: Chemistry. 2008;14(23):6892-900
references: 18601230
references: Nat Rev Drug Discov. 2004 Mar;3(3):205-14
references: 15031734
references: Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13733-8
references: 22869751
references: Chem Commun (Camb). 2011 Jul 21;47(27):7755-7
references: 21617817
references: J Nutr. 1999 Jul;129(7):1251-60
references: 10395584
references: Mol Cell Biol. 1997 Oct;17(10):5699-706
references: 9315628
references: Org Lett. 2009 Mar 19;11(6):1269-72
references: 19220060
references: Mol Aspects Med. 2013 Apr-Jun;34(2-3):561-70
references: 23506889
references: Curr Biol. 2011 Nov 8;21(21):R877-83
references: 22075424
references: J Am Chem Soc. 2004 Nov 17;126(45):14682-3
references: 15535668
references: Curr Opin Chem Biol. 2000 Apr;4(2):184-91
references: 10742195
references: J Am Chem Soc. 2012 Sep 26;134(38):16000-7
references: 22935018
references: Anal Chim Acta. 2011 Apr 8;691(1-2):83-8
references: 21458635
references: C R Biol. 2010 Jun-Jul;333(6-7):516-23
references: 20541163
references: Front Cell Infect Microbiol. 2013 Nov 05;3:73
references: 24205499
references: Chem Commun (Camb). 2010 Dec 28;46(48):9220-2
references: 20981376
references: Dalton Trans. 2009 Feb 21;(7):1180-6
references: 19322489
references: Annu Rev Neurosci. 2004;27:723-49
references: 15217349
references: Chem Commun (Camb). 2008 Dec 7;(45):5915-7
references: 19030537
references: Anal Chem. 2014 Jun 3;86(11):5353-9
references: 24825103
references: Chemistry. 2013 Nov 11;19(46):15494-503
references: 24166837
references: J Am Chem Soc. 2014 Jul 16;136(28):9838-41
references: 24967610
references: Chem Commun (Camb). 2006 Jan 7;(1):106-8
references: 16353108
references: J Am Chem Soc. 2007 Aug 15;129(32):9838-9
references: 17645334
references: Anal Chem. 2013 Jul 2;85(13):6461-8
references: 23745782
references: Org Lett. 2010 Jun 18;12(12):2876-9
references: 20499862
references: Org Lett. 2005 Mar 3;7(5):889-92
references: 15727467
references: J Toxicol Environ Health B Crit Rev. 2001 Oct-Dec;4(4):341-94
references: 11695043