title: Validation of an Alzheimer's disease assessment battery in Asian participants with mild to moderate Alzheimer's disease.
abstract: There is a lack of validated tools for assessing Alzheimer's disease (AD) across Asia. This study evaluates the psychometric properties of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Disability Assessment for Dementia (DAD), and Neuropsychological Test Battery (NTB) in Asian participants. Participants with mild to moderate AD (n=251) and healthy controls (n=51) from Mainland China, Taiwan, Singapore, Hong Kong, and South Korea completed selected instruments at several time points. Test-retest reliability was better than 0.70 for all tests. AD participants performed significantly more poorly than controls on every score. Within the AD group, greater disease severity corresponded to significantly poorer performance. The AD group test performance worsened over time and there was a trend for worse performance in AD compared to healthy controls over time. The ADAS-Cog, DAD, and NTB are reliable, valid, and responsive measures in this population and could be used for clinical trials across Asian countries/regions.
authors: Pfizer Inc Shanghai, China.
authors: Joan Hq
authors: JH
authors: Shen
authors: Clinical Science, Pfizer Inc 500 Arcola Rd, Collegeville, PA, USA.
authors: Qi
authors: Q
authors: Shen
authors: Pfizer Inc 500 Arcola Rd, Collegeville, PA, USA.
authors: Holly
authors: H
authors: Yu
authors: Medical Social Sciences, Feinberg School of Medicine at Northwestern University Chicago Illinois, USA.
authors: Jin-Shei
authors: JS
authors: Lai
authors: Medical Social Sciences, Feinberg School of Medicine at Northwestern University Chicago Illinois, USA.
authors: Jennifer L
authors: JL
authors: Beaumont
authors: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Services Beijing 100730, China.
authors: Zhenxin
authors: Z
authors: Zhang
authors: DementiaCare & ResearchCenter, Clinical Research Division, Peking University Institute of Mental Health Beijing, China.
authors: Huali
authors: H
authors: Wang
authors: Department of Psychiatry, Asan Medical Center, University of Ulsan, Medical College Seoul Korea.
authors: Seong Yoon
authors: SY
authors: Kim
authors: Department of Pharmacology, National University of Singapore Singapore.
authors: Christopher
authors: C
authors: Chen
authors: Department of Medicine & Therapeutics (Geriatric division), Prince of Wales Hospital, The Chinese University of Hong Kong Hong Kong, China.
authors: Timothy
authors: T
authors: Kwok
authors: Faculty of Medicine, National Yang-Ming University School of Medicine, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital Taipei, Taiwan.
authors: Shuu-Jiun
authors: SJ
authors: Wang
authors: Department of Neuropsychiatry, Seoul National University College of Medicine Seoul, Korea.
authors: Dong Young
authors: DY
authors: Lee
authors: Metis Cognition Ltd. Kilmington Common UK ; Department of Medicine, Imperial College London, UK.
authors: John
authors: J
authors: Harrison
authors: Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, NV; Cleveland, OH: Weston, FL, USA.
authors: Jeffrey
authors: J
authors: Cummings
keywords: Alzheimer’s disease; validation
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