title: Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy.
abstract: Advanced materials and fractal design concepts form the basis of a 3D conformal electronic platform with unique capabilities in cardiac electrotherapies. Fractal geometries, advanced electrode materials, and thin, elastomeric membranes yield a class of device capable of integration with the entire 3D surface of the heart, with unique operational capabilities in low power defibrillation. Co-integrated collections of sensors allow simultaneous monitoring of physiological responses. Animal experiments on Langendorff-perfused rabbit hearts demonstrate the key features of these systems.
authors: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1304 W. Green St., Urbana, IL, 61801, USA.
authors: Lizhi
authors: L
authors: Xu
authors: Sarah R
authors: SR
authors: Gutbrod
authors: Yinji
authors: Y
authors: Ma
authors: Artin
authors: A
authors: Petrossians
authors: Yuhao
authors: Y
authors: Liu
authors: R Chad
authors: RC
authors: Webb
authors: Jonathan A
authors: JA
authors: Fan
authors: Zijian
authors: Z
authors: Yang
authors: Renxiao
authors: R
authors: Xu
authors: John J
authors: JJ
authors: Whalen
authors: James D
authors: JD
authors: Weiland
authors: Yonggang
authors: Y
authors: Huang
authors: Igor R
authors: IR
authors: Efimov
authors: John A
authors: JA
authors: Rogers
mesh_terms: D000497:Alloys / Q000737:chemistry; D000818:Animals; D020724:Elastomers; D017097:Electric Impedance; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004867:Equipment Design; D017709:Fractals; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D007495:Iridium / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry; D061848:Optical Imaging; D017671:Platinum Compounds / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D011817:Rabbits; D012826:Silicone Elastomers; D018030:Silver Compounds / Q000737:chemistry; D013057:Spectrum Analysis; D013876:Thiophenes / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D020724:Elastomers; D017671:Platinum Compounds; D011137:Polystyrenes; D012826:Silicone Elastomers; D018030:Silver Compounds; D013876:Thiophenes; C533756:poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate); D007495:Iridium; D014025:Titanium
keywords: bio-electronic materials; cardiac electrotherapy; electrochemical methods; fractal designs; stretchable electronics
references: Heart. 2004 Mar;90(3):255-6
references: 14966038
references: Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H243-50
references: 15016625
references: Science. 2011 Aug 12;333(6044):838-43
references: 21836009
references: Heart Rhythm. 2009 Jul;6(7):1020-7
references: 19560090
references: Nat Commun. 2014;5:3266
references: 24509865
references: IEEE Trans Biomed Eng. 2008 Apr;55(4):1457-60
references: 18390340
references: Nat Commun. 2014 Feb 25;5:3329
references: 24569383
references: J Am Coll Cardiol. 2012 Dec 11;60(23):2393-8
references: 23141483
references: Heart Rhythm. 2006 Sep;3(9):1100-2
references: 16945810
references: Nat Mater. 2011 Apr;10(4):316-23
references: 21378969
references: Heart Lung. 2005 Nov-Dec;34(6):386-92
references: 16324957
references: IEEE Trans Neural Syst Rehabil Eng. 2001 Mar;9(1):2-11
references: 11482359
references: Nanotechnology. 2012 Aug 31;23(34):344004
references: 22885907
references: Biosens Bioelectron. 2011 Mar 15;26(7):3290-6
references: 21257302
references: J Neural Eng. 2011 Feb;8(1):014001
references: 21245527
references: Annu Rev Biomed Eng. 2008;10:275-309
references: 18429704
references: Circ Res. 1960 Nov;8:1171-81
references: 13715537
references: Nat Nanotechnol. 2011 Oct 23;6(12):788-92
references: 22020121
references: Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H753-65
references: 22821993
references: Circulation. 1997 Oct 21;96(8):2693-700
references: 9355911
references: Nat Mater. 2010 Jun;9(6):511-7
references: 20400953
references: Adv Mater. 2014 Mar 5;26(9):1427-33
references: 24150828
references: Biomaterials. 2008 Aug-Sep;29(24-25):3393-9
references: 18501423
references: Circulation. 1971 Feb;43(2):183-92
references: 5540704
references: Nature. 2013 Jul 25;499(7459):458-63
references: 23887430
references: Nature. 2011 Jul 13;475(7355):235-9
references: 21753855