title: Two new homoisoflavonoids from the bulbs of Bessera elegans.
abstract: A further chemical investigation of the bulbs of Bessera elegans (Liliaceae) led to the isolation of a new homoisoflavonoid (1), a new scillascillin-type homoisoflavonoid (2), three known flavonoids (3-5), and two known norlignans (6 and 7). The structures of the new homoisoflavonoids (1 and 2) were determined based on the results of extensive spectroscopic analysis, including two-dimensional NMR data. The isolated compounds (1-7) were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells and TIG-3 normal human diploid fibroblasts. Compound 1 exhibited potent tumor-selective cytotoxic activity against HL-60 cells.
authors: Yukiko
authors: Y
authors: Matsuo
authors: Risa
authors: R
authors: Kurihara
authors: Nana
authors: N
authors: Akagi
authors: Yoshihiro
authors: Y
authors: Mimaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D018922:HL-60 Cells; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019668:Liliaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones