title: Association between serum levels of homocysteine with characteristics of migraine attacks in migraine with aura.
abstract: BACKGROUND
  Evidences have shown that migraine with aura (MA) is associated with elevated homocysteine levels but, few studies have evaluated the relationship between homocysteine levels and characteristics of migraine attacks such as severity, frequency, duration and headache diary result (HDR). Thus, in this study, we investigated the association between homocysteine levels and characteristics of migraine attacks in patients with MA.
  
  
  METHODS
  This cross-sectional study was carried out in Isfahan city, Iran, in February 2013. Fasting serum levels of homocysteine were measured in 130 MA patients (31 males and 99 females) aged 15-60 years. Severity, frequency and duration of migraine attacks, as well as HDR, were determined in each patient according to international headache society criteria by a neurologist. Linear and ordinal logistic regression tests were used to evaluate the relationship between serum homocysteine levels and characteristics of migraine attacks.
  
  
  RESULTS
  There is no significant association between serum levels of homocysteine with severity, frequency, duration and HDR. This association was not significant after adjustment of confounding variables such as age, body mass index (BMI) and family history of migraine. However, serum homocysteine levels were significantly associated with HDR among males after adjustment for age, BMI and family history of migraine (P = 0.01).
  
  
  CONCLUSIONS
  Significant relationship between homocysteine levels and characteristics of migraine attacks such as severity, frequency, duration and HDR were not found. However, after adjustment of confounding variables, we found a significant positive relationship between homocysteine levels and HDR among men.
authors: Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Omid
authors: O
authors: Sadeghi
authors: Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Zahra
authors: Z
authors: Maghsoudi
authors: Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Gholamreza
authors: G
authors: Askari
authors: Neurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Fariborz
authors: F
authors: Khorvash
authors: Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Awat
authors: A
authors: Feizi
keywords: Duration; frequency; homocysteine; migraine; severity
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