title: No reactivation of JCV and CMV infections in the temporal cortex and cerebellum of sporadic Creutzfeldt-Jakob disease patients.
abstract: Sporadic Creutzfeldt-Jakob disease (sCJD) is characterized by great phenotypic variability regarding clinical course and neuropathology. The most prominent disease modifiers are a polymorphism in Codon 129 of the prion protein gene and conformational variations of the misfolded prion protein. The cellular form of the prion protein restricts replication of viruses and may be involved in viral host defense, and viral infections influence the presentation and neuropathology in prion diseased mice. We investigated the occurrence of reactivated persistent viral infections of the brain in brain tissue samples of 25 sCJD patients. No evidence of reactivated JCV and CMV infections could be detected. This suggests that JCV and CMV infections are not reactivated as consequence of prion disease and do not act as disease modifiers in sCJD.
authors: Institute of Neuropathology, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
authors: Judith
authors: J
authors: Löffler
authors: Institute of Neuropathology, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
authors: Susanne
authors: S
authors: Krasemann
authors: National Reference Center for TSE, Medical Center Georg-August University Goettingen, Germany.
authors: Inga
authors: I
authors: Zerr
authors: Institute of Neuropathology, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
authors: Jakob
authors: J
authors: Matschke
authors: Institute of Neuropathology, University Medical Center Hamburg-Eppendorf Hamburg, Germany.
authors: Markus
authors: M
authors: Glatzel
keywords: CMV; Creutzfeldt-Jakob disease; JCV; Prion; disease modifier; persistent viral infection
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