title: Long-term outcome after transcatheter aortic valve implantation.
abstract: OBJECTIVE
  To assess late outcome after transcatheter aortic valve implantation (TAVI) up to 6 years and to analyse its predictive factors with a particular emphasis on functional status. Very few data exist on the long-term results of TAVI, and these data are crucial for decision making.
  
  
  METHODS
  Between October 2006 and December 2009, 123 consecutive patients were discharged alive after TAVI in our institution. Mean age was 82±8 years, and 88% of patients were highly symptomatic in New York Heart Association (NYHA) class III-IV.
  
  
  RESULTS
  Follow-up was complete in 122 patients (99%). The overall 6-year survival rate was 31%±5%, the majority of deaths being non-cardiac. Predictive factors of late mortality were the presence of lower limb arteritis (p=0.009), a higher Charlson comorbidity index (p=0.03) and post-TAVI paraprosthetic aortic regurgitation ≥2/4 (p=0.01). Late outcomes according to Valve Academic Research Consortium-2 criteria were analysed, and the 5-year event-free survival rate was 28%±4%. Finally, the rate of good functional results, defined as survival in NYHA class I or II, was 32%±5% at 5-year follow-up. In the survivors, the EQ-5D questionnaire further confirmed the benefit in terms of quality of life.
  
  
  CONCLUSIONS
  About one-third of patients discharged alive after TAVI were alive at 6-year follow-up, and the survivors exhibited good functional results assessed by NYHA class and quality-of-life standardised evaluation.
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France Faculté de Médecine Paris-Diderot University Paris 7, Paris, France.
authors: Claire
authors: C
authors: Bouleti
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France INSERM U698 Bichat Hospital, Paris, France.
authors: Dominique
authors: D
authors: Himbert
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France Faculté de Médecine Paris-Diderot University Paris 7, Paris, France INSERM U698 Bichat Hospital, Paris, France.
authors: Bernard
authors: http://orcid.org/0000-0002-9127-348X
authors: B
authors: Iung
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Benjamin
authors: B
authors: Alos
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Caroline
authors: C
authors: Kerneis
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Walid
authors: W
authors: Ghodbane
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France Faculté de Médecine Paris-Diderot University Paris 7, Paris, France INSERM U698 Bichat Hospital, Paris, France.
authors: David
authors: D
authors: Messika-Zeitoun
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Eric
authors: E
authors: Brochet
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Amir-Ali
authors: AA
authors: Fassa
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Jean-Pol
authors: JP
authors: Depoix
authors: Department of Radiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
authors: Phalla
authors: P
authors: Ou
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France Faculté de Médecine Paris-Diderot University Paris 7, Paris, France.
authors: Patrick
authors: P
authors: Nataf
authors: Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France Faculté de Médecine Paris-Diderot University Paris 7, Paris, France INSERM U698 Bichat Hospital, Paris, France.
authors: Alec
authors: A
authors: Vahanian
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D011183:Postoperative Complications; D011788:Quality of Life; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome