title: Stromal cell-derived factor 1 (SDF-1) accelerated skin wound healing by promoting the migration and proliferation of epidermal stem cells.
abstract: Epidermal stem cells could contribute to skin repair through the migration of cells from the neighboring uninjured epidermis, infundibulum, hair follicle, or sebaceous gland. However, little is known about the factors responsible for the complex biological processes in wound healing. Herein, we will show that the attracting chemokine, SDF-1/CXCR4, is a major regulator involved in the migration of epidermal stem cells during wound repair. We found that the SDF-1 levels were markedly increased at the wound margins following injury and CXCR4 expressed in epidermal stem cells and proliferating epithelial cells. Blocking the SDF-1/CXCR4 axis resulted in a significant reduction in epidermal stem cell migration toward SDF-1 in vitro and delayed wound healing in vivo, while an SDF-1 treatment enhanced epidermal stem cell migration and proliferation and accelerated wound healing. These results provide direct evidence that SDF-1 promotes epidermal stem cell migration, accelerates skin regeneration, and makes the development of new regenerative therapeutic strategies for wound healing possible.
authors: Department of Plastic and Reconstructive Surgery, Southwestern Hospital, Third Military Medical University, Chongqing, 400038, China.
authors: Rui
authors: R
authors: Guo
authors: Linlin
authors: L
authors: Chai
authors: Liang
authors: L
authors: Chen
authors: Wenguang
authors: W
authors: Chen
authors: Liangpeng
authors: L
authors: Ge
authors: Xiaoge
authors: X
authors: Li
authors: Hongli
authors: H
authors: Li
authors: Shirong
authors: S
authors: Li
authors: Chuan
authors: C
authors: Cao
mesh_terms: D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004817:Epidermis / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D017207:Rats, Sprague-Dawley; D019718:Receptors, CXCR4 / Q000378:metabolism; D013234:Stem Cells / Q000473:pathology*; D015854:Up-Regulation; D014945:Wound Healing
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4
references: J Invest Dermatol. 2006 Feb;126(2):468-76
references: 16385346
references: J Clin Invest. 2007 May;117(5):1249-59
references: 17476357
references: Am J Pathol. 1999 Nov;155(5):1577-86
references: 10550315
references: Nat Med. 2004 Aug;10(8):858-64
references: 15235597
references: Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9448-53
references: 9689100
references: J Clin Invest. 2005 Jan;115(1):86-93
references: 15630447
references: Br J Dermatol. 2007 Dec;157(6):1148-54
references: 17941943
references: Leukemia. 2006 Nov;20(11):1915-24
references: 16900209
references: Lancet. 2001 Sep 29;358(9287):1067-8
references: 11589942
references: Cell. 2004 Sep 3;118(5):635-48
references: 15339667
references: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13473-5
references: 11087834
references: Science. 1982 Mar 5;215(4537):1239-41
references: 7058342
references: Nature. 2008 May 15;453(7193):314-21
references: 18480812
references: FASEB J. 2007 May;21(7):1358-66
references: 17255473
references: Lancet. 2005 Nov 12;366(9498):1736-43
references: 16291068
references: Cell Tissue Res. 2009 Feb;335(2):317-21
references: 19034523
references: Lancet. 2003 Aug 30;362(9385):697-703
references: 12957092
references: Immunity. 2003 Aug;19(2):257-67
references: 12932359
references: Stem Cells. 2006 Dec;24(12):2810-6
references: 16931770
references: Antioxid Redox Signal. 2008 Nov;10(11):1869-82
references: 18627349
references: J Clin Invest. 2003 Jul;112(2):160-9
references: 12865405
references: Nature. 1998 Jun 11;393(6685):595-9
references: 9634238
references: J Clin Invest. 2007 May;117(5):1219-22
references: 17476353
references: Eur J Cell Biol. 2007 Jul;86(7):355-76
references: 17576022
references: J Clin Invest. 2000 Dec;106(11):1331-9
references: 11104786
references: Nature. 1996 Aug 15;382(6592):635-8
references: 8757135
references: Am J Pathol. 2004 Jun;164(6):1935-47
references: 15161630
references: J Exp Med. 1997 Jan 6;185(1):111-20
references: 8996247
references: Dev Biol. 1999 Sep 15;213(2):442-56
references: 10479460
references: Blood. 2005 Apr 15;105(8):3155-61
references: 15626744