title: [Epidemiology and characterization of high-risk genotypes of human Papillomavirus in a population of sexually active adolescents in Ouagadougou].
abstract: OBJECTIVE
  This cross-sectional study was to determine the prevalence and characterization of high-risk HPV genotypes circulating among adolescents in Ouagadougou.
  
  
  METHODS
  From September to December 2013, 200 adolescents recruited from a youth counseling center have voluntarily accepted a swab of the endocervical canal. The identification of the genotypes of the human Papillomavirus (HPV) was performed by real-time polymerase chain reaction technique.
  
  
  RESULTS
  The mean age of adolescents was 18.7±0.7 years and 83/200 adolescents were positive for at least one high-risk genotype HPV a prevalence of 41.5%. Twelve genotypes corresponding to 136 infections were characterized: HPV 52 (22.8%), HPV 59 (14.0%), HPV 39 (13.2%), HPV 35 (10.3%), HPV 51 (10.3%), HPV 56 (8.8%), HPV 16 (5.2%), HPV 18 (5.2%), HPV 58 (4.4%), HPV 31 (3.6%), HPV 45 (1.5%), HPV 33 (0.7%). Multiple infections (2-5 virus) statistically associated with age (p=0.0318) was detected in 42.2% of infected females. If the number of sexual partners was statistically associated with the porting of HPV (OR=2.18; 95% CI=1.17 to 4.09), early sexual intercourse and the recent change of sexual partner were not (p>0,05) CONCLUSION: The prevalence of carriage of HPV in this study is high, as described in young people at the start of sexual activity. Identified genotypes are different from those targeted by prophylactic vaccines currently available. A larger study to map genotypes of high-risk HPV circulating in West Africa is necessary for a suitable vaccine.
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Gynécologues obstétriciens, CHU Yalgado Ouédraogo de Ouagadougou, 04 BP 8201, Ouagadougou 04, Burkina Faso. Electronic address: ocharlemagne@yahoo.fr.
authors: C M R
authors: CM
authors: Ouédraogo
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso.
authors: R M L
authors: RM
authors: Rahimy
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso.
authors: T M
authors: TM
authors: Zohoncon
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso.
authors: F W
authors: FW
authors: Djigma
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso.
authors: A T
authors: AT
authors: Yonli
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso.
authors: D
authors: D
authors: Ouermi
authors: Université d'Abomey-Calavi, Bénin.
authors: A
authors: A
authors: Sanni
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Gynécologues obstétriciens, CHU Yalgado Ouédraogo de Ouagadougou, 04 BP 8201, Ouagadougou 04, Burkina Faso.
authors: J
authors: J
authors: Lankoande
authors: Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso.
authors: J
authors: J
authors: Simpore
mesh_terms: D000293:Adolescent; D002050:Burkina Faso / Q000453:epidemiology; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012306:Risk
keywords: Adolescent girls; Adolescentes; HPV à haut risque; High-risk HPV; Ouagadougou; PCR en temps réel; Real time PCR