title: Two-year accelerated corneal cross-linking outcome in patients with progressive keratoconus.
abstract: OBJECTIVE
  To evaluate the long-term results of accelerated corneal cross-linking (CXL) in patients with progressive keratoconus.
  
  
  METHODS
  Sixteen patients underwent accelerated CXL at 6 mW/cm(2) for 15 minutes in one eye. The follow-up visits were scheduled on 7 days, 14 days, and 3, 12, and 24 months after the treatment.
  
  
  RESULTS
  There were no significant differences (P > 0.05) between preoperative and 2-year postoperative mean values, respectively, in terms of uncorrected visual acuity, best spectacle-corrected visual acuity, maximum keratometry K max⁡, minimum keratometry K min⁡, corneal astigmatism, and corneal eccentricity index. We noted a significant flattening of the cornea in 18.7% of patients with a higher preoperative K max⁡ value (>50 D) and its steepening in patients with a lower K max⁡ value (<50 D) (6.25%). There was no significant difference in the central corneal thickness and the apical corneal thickness preoperatively and 2 years postoperatively. The mean demarcation line depth was 282 ± 11 μm. Persistent corneal haze was noted in 25% of patients.
  
  
  CONCLUSIONS
  Accelerated CXL appears to be a relatively effective procedure for the treatment of keratoconus in 2-year follow-up.
authors: Department of Ophthalmology and Vision Rehabilitation, Medical University of Łódź, Żeromskiego 113, 90-549 Łódź, Poland.
authors: Arleta
authors: 0000-0002-4950-6390
authors: A
authors: Waszczykowska
authors: Department of Ophthalmology and Vision Rehabilitation, Medical University of Łódź, Żeromskiego 113, 90-549 Łódź, Poland.
authors: Piotr
authors: P
authors: Jurowski
mesh_terms: D000328:Adult; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D063171:Corneal Pachymetry; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D003432:Cross-Linking Reagents
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