title: Identifying outcome predictors of transoral laser cordectomy for early glottic cancer.
abstract: The purpose of this study was to determine the predictors of outcomes in patients with early glottic cancer treated by transoral laser cordectomy.
  
  
  
  This was an inception cohort study of 201 patients with early glottic cancer who were treated by transoral laser cordectomy. Five-year Kaplan-Meier analyses were realized.
  
  
  
  Patients with anterior commissure involvement (n = 75) had a significantly lower disease-free survival (DFS) rate (54.6% vs 79.8%; p = .0004), ultimate local control with laser alone rate (71.0% vs 95.7%; p <  .0001), laryngeal preservation rate (91.6% vs 100%; p = .0003), and disease-specific survival (DSS) rate (90.8% vs 99.0%; p = .03). There was no significant difference in overall-survival (OS) rates (76.9% vs 88.5%; p = .29). Surgical margin status was not found to be a significant predictor of outcomes in this series.
  
  
  
  Although anterior commissure involvement has a significant impact on outcomes, laser cordectomy remains a valuable option considering its high organ preservation and survival rates. In cases of local recurrence, all standard further treatment options remain available. © 2015 Wiley Periodicals, Inc. Head Neck 38: E406-E411, 2015.
authors: Department of Otolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Paris, France.
authors: Caroline
authors: C
authors: Hoffmann
authors: Department of Otolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Paris, France.
authors: Stéphane
authors: S
authors: Hans
authors: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, NY.
authors: Babak
authors: B
authors: Sadoughi
authors: Department of Otolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Paris, France.
authors: Daniel
authors: D
authors: Brasnu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: carbon dioxide laser; glottis; laryngeal carcinoma; laryngoscopic surgery; squamous cell carcinoma