title: An optimal control strategy to reduce the spread of malaria resistance.
abstract: This paper presents a mathematical model of malaria transmission considering the resistance of malaria parasites to the anti-malarial drugs. The model also incorporates mass treatment and insecticide as control strategies. We consider the sensitive and resistant strains of malaria parasites in human and mosquito populations. First, we investigated the existence and stability of equilibria of the model without control based on two basic reproduction ratios corresponding to the strains. Then, the Pontryagins Maximum Principle is applied to derive the necessary conditions for optimal control. Simulation results show the effectiveness of the optimal control to reduce the number of infected hosts and vectors.
authors: Department of Mathematics, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia. Electronic address: fatmawati@fst.unair.ac.id.
authors: Fatmawati
authors: Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok 16424, Indonesia. Electronic address: htasman@sci.ui.ac.id.
authors: Hengki
authors: H
authors: Tasman
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D003198:Computer Simulation; D009033:Culicidae / Q000469:parasitology; D004351:Drug Resistance; D006801:Humans; D007306:Insecticides; D008288:Malaria / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D055641:Mathematical Concepts; D008954:Models, Biological
chemical_list: D000962:Antimalarials; D007306:Insecticides
keywords: Basic reproduction ratio; Malaria resistance; Mathematical model; Optimal control