title: Reactivation of hepatitis B virus (HBV) infection in adult T-cell leukemia-lymphoma patients with resolved HBV infection following systemic chemotherapy.
abstract: Reactivation of hepatitis B virus (HBV) infection may occur in adult T-cell leukemia-lymphoma (ATL) patients with resolved HBV infection who receive monotherapy with the anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab. However, there is little evidence regarding the incidence and characteristics of HBV reactivation in ATL patients receiving systemic chemotherapy, including the use of this antibody. We conducted a retrospective study for 24 ATL patients with resolved HBV infection underwent regular HBV DNA monitoring to assess HBV reactivation in Nagoya City University Hospital between January 2005 and June 2013. With median HBV DNA follow-up of 238 days (range 57-1420), HBV reactivation (defined as the detection of HBV DNA) was observed in three (12.5 %) of 24 patients with resolved HBV infection. No hepatitis due to HBV reactivation occurred in those patients who were diagnosed with HBV DNA levels below 2.1 log copies/mL and who received antiviral drugs. Mogamulizumab was administered prior to HBV reactivation in two of three HBV-reactivated patients. In the mogamulizumab era, further well-designed prospective studies are warranted to estimate the incidence of HBV reactivation and to establish regular HBV DNA monitoring-guided preemptive antiviral therapy for such patients.
authors: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
authors: Haruhito
authors: H
authors: Totani
authors: Shigeru
authors: S
authors: Kusumoto
authors: Takashi
authors: T
authors: Ishida
authors: Arisa
authors: A
authors: Masuda
authors: Takashi
authors: T
authors: Yoshida
authors: Asahi
authors: A
authors: Ito
authors: Masaki
authors: M
authors: Ri
authors: Hirokazu
authors: H
authors: Komatsu
authors: Shuko
authors: S
authors: Murakami
authors: Masashi
authors: M
authors: Mizokami
authors: Ryuzo
authors: R
authors: Ueda
authors: Akio
authors: A
authors: Niimi
authors: Hiroshi
authors: H
authors: Inagaki
authors: Yasuhito
authors: Y
authors: Tanaka
authors: Shinsuke
authors: S
authors: Iida
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000998:Antiviral Agents; D004279:DNA, Viral; C549035:mogamulizumab
references: J Clin Oncol. 2009 Feb 1;27(4):605-11
references: 19075267
references: J Clin Oncol. 2012 Mar 10;30(8):837-42
references: 22312108
references: J Clin Oncol. 2010 Mar 20;28(9):1591-8
references: 20177026
references: Cancer Sci. 2011 Jan;102(1):44-50
references: 21044233
references: JAMA. 2013 Oct 23;310(16):1664
references: 24150447
references: Hepatology. 2014 Jun;59(6):2092-100
references: 24002804
references: J Gastroenterol. 2011 Jan;46(1):9-16
references: 20924616
references: Int J Hematol. 2013 Aug;98(2):258-60
references: 23801427
references: Hepatol Res. 2014 Mar;44(3):354-7
references: 23601025
references: Hepatol Res. 2012 Jul;42(7):627-36
references: 22686858
references: Int J Hematol. 2011 Nov;94(5):443-52
references: 21993874
references: Hepatol Res. 2008 Mar;38(3):234-43
references: 17877727
references: J Hepatol. 2012 Jul;57(1):167-85
references: 22436845
references: Int J Hematol. 2009 Jul;90(1):13-23
references: 19544079
references: J Clin Oncol. 2007 Dec 1;25(34):5458-64
references: 17968021
references: Clin Cancer Res. 2010 Mar 1;16(5):1520-31
references: 20160057
references: Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3625-34
references: 14506150
references: Gastroenterology. 2006 Jul;131(1):59-68
references: 16831590
references: Gastroenterology. 1991 Jan;100(1):182-8
references: 1983820