title: Local morphology predicts functional organization of experienced value signals in the human orbitofrontal cortex.
abstract: Experienced value representations within the human orbitofrontal cortex (OFC) are thought to be organized through an antero-posterior gradient corresponding to secondary versus primary rewards. Whether this gradient depends upon specific morphological features within this region, which displays considerable intersubject variability, remains unknown. To test the existence of such relationships, we performed a subject-by-subject analysis of fMRI data taking into account the local morphology of each individual. We tested 38 subjects engaged in a simple incentive delay task manipulating both monetary and visual erotic rewards, focusing on reward outcome (experienced value signal). The results showed reliable and dissociable primary (erotic) and secondary (monetary) experienced value signals at specific OFC sulci locations. More specifically, experienced value signal induced by monetary reward outcome was systematically located in the rostral portion of the medial orbital sulcus. Experienced value signal related to erotic reward outcome was located more posteriorly, that is, at the intersection between the caudal portion of the medial orbital sulcus and transverse orbital sulcus. Thus, the localizations of distinct experienced value signals can be predicted from the organization of the human orbitofrontal sulci. This study provides insights into the anatomo-functional parcellation of the anteroposterior OFC gradient observed for secondary versus primary rewards because there is a direct relationship between value signals at the time of reward outcome and unique OFC sulci locations.
authors: Reward and Decision-Making Team, Cognitive Neuroscience Center, CNRS UMR 5229, 69675 Bron, France, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France, and dreher@isc.cnrs.fr liyansongrenzs@gmail.com.
authors: Yansong
authors: Y
authors: Li
authors: Reward and Decision-Making Team, Cognitive Neuroscience Center, CNRS UMR 5229, 69675 Bron, France, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France, and.
authors: Guillaume
authors: G
authors: Sescousse
authors: Université Claude Bernard Lyon 1, 69100 Villeurbanne, France, and Institut National de la Santé et de la Recherche Médicale U846, Stem Cell and Brain Research Institute, 69500 Bron, France.
authors: Céline
authors: C
authors: Amiez
authors: Reward and Decision-Making Team, Cognitive Neuroscience Center, CNRS UMR 5229, 69675 Bron, France, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France, and dreher@isc.cnrs.fr liyansongrenzs@gmail.com.
authors: Jean-Claude
authors: JC
authors: Dreher
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D012201:Reward; D012725:Sexual Behavior / Q000523:psychology; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: experienced value; fMRI; local morphology; orbitofrontal cortex; reward
references: Neuropsychopharmacology. 2010 Jan;35(1):4-26
references: 19812543
references: Curr Opin Neurobiol. 2009 Feb;19(1):84-91
references: 19427193
references: Ann N Y Acad Sci. 2007 Dec;1121:54-71
references: 17698999
references: Nat Neurosci. 2013 Apr;16(4):479-85
references: 23416449
references: Eur J Neurosci. 2013 Sep;38(5):2793-801
references: 23773118
references: Cereb Cortex. 2003 Oct;13(10):1064-71
references: 12967923
references: Soc Cogn Affect Neurosci. 2014 Sep;9(9):1289-302
references: 23887811
references: Annu Rev Neurosci. 2007;30:31-56
references: 17417936
references: J Neurosurg. 2008 Feb;108(2):258-68
references: 18240920
references: Nat Rev Neurosci. 2014 Aug;15(8):549-62
references: 24986556
references: Curr Opin Neurobiol. 2012 Dec;22(6):1027-38
references: 22766486
references: J Neurosci. 2012 May 2;32(18):6240-50
references: 22553030
references: J Neurosci. 2010 Sep 29;30(39):13095-104
references: 20881127
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: J Neurosci. 2007 Aug 1;27(31):8166-9
references: 17670960
references: Cereb Cortex. 2000 Mar;10(3):206-19
references: 10731217
references: J Comp Neurol. 1989 Aug 15;286(3):353-75
references: 2768563
references: Prog Neurobiol. 2004 Apr;72(5):341-72
references: 15157726
references: J Neurosci. 2010 Oct 20;30(42):14080-90
references: 20962229
references: Cereb Cortex. 2011 Apr;21(4):769-76
references: 20732900
references: Trends Cogn Sci. 2011 Feb;15(2):56-67
references: 21216655
references: Nat Rev Neurosci. 2005 May;6(5):363-75
references: 15832198
references: Acta Psychiatr Scand. 1983 Jun;67(6):361-70
references: 6880820
references: Neuroimage. 2003 Jul;19(3):1233-9
references: 12880848
references: Nat Rev Neurosci. 2005 Sep;6(9):691-702
references: 16136173
references: J Neurosci. 2013 Jan 30;33(5):2217-28
references: 23365257
references: Behav Brain Res. 2010 Dec 1;213(2):135-41
references: 20420859
references: Neuroimage. 2012 Feb 15;59(4):3829-37
references: 22155041
references: Postgrad Med. 1972 Dec;52(6):81-5
references: 4635613
references: Cereb Cortex. 2008 Mar;18(3):652-63
references: 17586603
references: Neuroimage. 2013 Aug 1;76:412-27
references: 23507394
references: Soc Cogn Affect Neurosci. 2015 Apr;10(4):467-73
references: 24837478
references: J Comp Neurol. 2003 Jun 2;460(3):425-49
references: 12692859
references: J Comp Neurol. 1995 Dec 25;363(4):615-641
references: 8847421
references: J Comp Neurol. 2000 Jun 19;422(1):35-54
references: 10842217
references: Prog Neurobiol. 2009 Oct;89(2):220-30
references: 19665515
references: J Comp Neurol. 1996 Jul 22;371(2):179-207
references: 8835726
references: Curr Biol. 2005 Mar 29;15(6):543-8
references: 15797023
references: Behav Brain Res. 2009 Mar 2;198(1):149-58
references: 19028527
references: Brain. 2013 Aug;136(Pt 8):2527-38
references: 23757765
references: Neurosci Biobehav Rev. 2013 May;37(4):681-96
references: 23415703
references: Neuroscience. 2009 Mar 31;159(3):1089-107
references: 19356690
references: J Neurosci. 2013 Feb 13;33(7):3202-11
references: 23407973
references: Nat Rev Clin Oncol. 2012 Dec;9(12):700-11
references: 23149894
references: Cereb Cortex. 2014 Mar;24(3):563-78
references: 23131805
references: Cereb Cortex. 1999 Oct-Nov;9(7):705-11
references: 10554993
references: J Neurosci. 2006 Mar 8;26(10):2724-31
references: 16525051