title: T-cell-mediated antitumor immunity in B-cell non-Hodgkin lymphoma: activation, suppression and exhaustion.
abstract: The tumor microenvironment in B-cell non-Hodgkin lymphoma (NHL) comprises not only malignant cells but also significant numbers of normal immune cells. The intratumoral immune infiltrate includes T-lymphocytes that appear to target the malignant clone. Despite immunologically recognizing the lymphoma cells, the intratumoral T-cells are unable to eradicate the malignant cells and the lymphoma commonly progresses. Recent data has identified mechanisms whereby activated intratumoral T-cells are suppressed or become exhausted due to chronic antigen stimulation. A clearer understanding of these mechanisms will allow for strategies to overcome them and improve the outcome of patients with lymphoma.
authors: a Division of Hematology and Internal Medicine, Mayo Clinic , Rochester , MN , USA.
authors: Zhi-Zhang
authors: ZZ
authors: Yang
authors: b Department of Hematology , Tongji Hospital, Tongji University , Shanghai , China.
authors: Ai-Bin
authors: AB
authors: Liang
authors: a Division of Hematology and Internal Medicine, Mayo Clinic , Rochester , MN , USA.
authors: Stephen M
authors: SM
authors: Ansell
mesh_terms: D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D016207:Cytokines
keywords: Lymphoma; T cells; anti-tumour immunity