title: Regulatory roles of RNA binding proteins in the nervous system of C. elegans.
abstract: Neurons have evolved to employ many factors involved in the regulation of RNA processing due to their complex cellular compartments. RNA binding proteins (RBPs) are key regulators in transcription, translation, and RNA degradation. Increasing studies have shown that regulatory RNA processing is critical for the establishment, functionality, and maintenance of neural circuits. Recent advances in high-throughput transcriptomics have rapidly expanded our knowledge of the landscape of RNA regulation, but also raised the challenge for mechanistic dissection of the specific roles of RBPs in complex tissues such as the nervous system. The C. elegans genome encodes many RBPs conserved throughout evolution. The rich analytic tools in molecular genetics and simple neural anatomy of C. elegans offer advantages to define functions of genes in vivo at the level of a single cell. Notably, the discovery of microRNAs has had transformative effects to the understanding of neuronal development, circuit plasticity, and neurological diseases. Here we review recent studies unraveling diverse roles of RBPs in the development, function, and plasticity of C. elegans nervous system. We first summarize the general technologies for studying RBPs in C. elegans. We then focus on the roles of several RBPs that control gene- and cell-type specific production of neuronal transcripts.
authors: Division of Biological Sciences, Neurobiology Section, University of California San Diego, La Jolla, CA, USA ; Neurosciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
authors: Panid
authors: P
authors: Sharifnia
authors: Division of Biological Sciences, Neurobiology Section, University of California San Diego, La Jolla, CA, USA ; Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA, USA.
authors: Yishi
authors: Y
authors: Jin
keywords: C. elegans; RBPs; mRNA; mRNA splicing; microRNAs; nervous system
references: Nucleic Acids Res. 2013 Apr;41(7):4015-25
references: 23416545
references: Mol Cell. 2012 May 25;46(4):530-41
references: 22503424
references: Cell. 2005 Feb 11;120(3):407-20
references: 15707898
references: WormBook. 2006 Apr 18;:1-13
references: 18050487
references: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10450-10455
references: 16803962
references: Nat Struct Mol Biol. 2010 Feb;17(2):173-9
references: 20062054
references: Mol Cell. 2007 Nov 30;28(4):598-613
references: 18042455
references: Genetics. 1994 Sep;138(1):83-101
references: 8001796
references: Cell Mol Life Sci. 2013 Dec;70(23):4411-30
references: 23475111
references: Cell. 1991 Oct 18;67(2):325-33
references: 1655278
references: Science. 2010 Jul 23;329(5990):432-5
references: 20522740
references: Nature. 2003 Dec 18;426(6968):845-9
references: 14685240
references: Science. 2013 Apr 19;340(6130):372-376
references: 23599497
references: Cell. 2009 Sep 4;138(5):1005-18
references: 19737525
references: Nature. 1998 Sep 3;395(6697):78-82
references: 9738501
references: Curr Biol. 2004 Nov 23;14(22):2057-62
references: 15556870
references: Neuron. 2000 May;26(2):345-56
references: 10839354
references: Neuron. 2002 Dec 5;36(5):933-44
references: 12467596
references: Genome Res. 2011 Feb;21(2):342-8
references: 21177968
references: Nat Struct Mol Biol. 2008 Apr;15(4):346-53
references: 18345015
references: Science. 2001 Oct 26;294(5543):862-4
references: 11679672
references: Cell. 2013 Aug 29;154(5):1010-1022
references: 23993094
references: Science. 2009 Dec 11;326(5959):1549-54
references: 20007902
references: Nucleic Acids Res. 2005 Dec 02;33(21):6805-15
references: 16326862
references: Neuron. 2000 Mar;25(3):575-86
references: 10774726
references: Development. 2002 Nov;129(21):4999-5008
references: 12397108
references: PLoS Genet. 2013 Jun;9(6):e1003592
references: 23818874
references: Mol Cell Neurosci. 2013 Sep;56:429-35
references: 23583633
references: Genes Cells. 2000 Nov;5(11):885-895
references: 11122376
references: Nat Methods. 2010 May;7(5):407-11
references: 20364149
references: Nucleic Acids Res. 2014;42(17):10873-87
references: 25183524
references: Development. 1998 Apr;125(8):1561-8
references: 9502737
references: Cell. 1991 Nov 29;67(5):955-67
references: 1720354
references: Trends Cell Biol. 2009 Sep;19(9):465-74
references: 19716303
references: Nature. 1978 Feb 23;271(5647):764-6
references: 625347
references: Genetics. 2014 Nov;198(3):1101-15
references: 25194163
references: Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):104-21
references: 22180311
references: Nat Neurosci. 2010 Dec;13(12):1489-95
references: 21037582
references: Development. 2010 Jul;137(13):2237-50
references: 20530551
references: Nat Rev Neurosci. 2009 Aug;10(8):597-609
references: 19584893
references: Mol Cell. 2009 Oct 23;36(2):231-44
references: 19800275
references: Cell Cycle. 2011 Jan 1;10(1):39-44
references: 21191181
references: Cell. 2008 May 30;133(5):903-15
references: 18510933
references: Development. 1996 May;122(5):1601-10
references: 8625846
references: Neuron. 2002 Dec 19;36(6):1079-89
references: 12495623
references: J Neurosci. 2001 Mar 1;21(5):1510-22
references: 11222641
references: Curr Biol. 2003 Aug 5;13(15):1317-23
references: 12906792
references: J Neurogenet. 1985 Jun;2(3):197-218
references: 3926976
references: Neuron. 2000 May;26(2):331-43
references: 10839353
references: Trends Cell Biol. 2011 Feb;21(2):104-12
references: 21115348
references: J Biol Chem. 2001 Apr 13;276(15):11913-21
references: 11110798
references: Nature. 2002 Feb 28;415(6875):1039-42
references: 11875573
references: Neuron. 1995 Apr;14(4):803-12
references: 7718242
references: J Biol Chem. 1997 Oct 31;272(44):27877-85
references: 9346935
references: Genome Res. 2008 Dec;18(12):2005-15
references: 18981266
references: Cell. 2014 Mar 13;156(6):1153-1166
references: 24630719
references: Development. 1997 Nov;124(21):4321-31
references: 9334280
references: Science. 2001 Oct 26;294(5543):853-8
references: 11679670
references: Cell. 1993 Dec 3;75(5):843-54
references: 8252621
references: Nature. 2011 Jan 6;469(7328):97-101
references: 21085120
references: Neuron. 2009 Jan 15;61(1):57-70
references: 19146813
references: Cell. 1993 Dec 3;75(5):855-62
references: 8252622
references: Nature. 1999 Sep 23;401(6751):371-5
references: 10517634
references: Neuron. 2012 Feb 9;73(3):453-65
references: 22325199
references: Cell. 2001 Jul 13;106(1):23-34
references: 11461699
references: Mol Cell Neurosci. 2013 Sep;56:447-55
references: 23439364
references: Science. 2001 Oct 26;294(5543):858-62
references: 11679671
references: Nature. 2004 Aug 12;430(7001):785-9
references: 15306811
references: Dev Biol. 1981 Mar;82(2):358-70
references: 7227647
references: Neuron. 2011 Sep 22;71(6):1043-57
references: 21943602
references: Mol Cell. 2012 Feb 24;45(4):567-80
references: 22365833
references: Nature. 1998 Feb 19;391(6669):806-11
references: 9486653
references: Mol Cell. 2005 Aug 19;19(4):437-47
references: 16109369
references: Mol Cell Biol. 1993 Jan;13(1):626-37
references: 8417357
references: PLoS Genet. 2013;9(2):e1003337
references: 23468662
references: PLoS Genet. 2012 Sep;8(9):e1002940
references: 23028351
references: Cell. 1993 Aug 13;74(3):515-27
references: 8348618
references: Genes Dev. 2013 Jul 1;27(13):1473-83
references: 23796896
references: Biochemistry (Mosc). 2012 Mar;77(3):217-26
references: 22803940
references: Genetics. 1992 Oct;132(2):431-42
references: 1427037
references: Science. 2010 Dec 24;330(6012):1775-87
references: 21177976
references: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3384-7
references: 9096403
references: Am J Med. 1986 Jan;80(1):45-52
references: 2417479
references: Mol Cell. 2014 Jun 19;54(6):946-959
references: 24910101
references: Wiley Interdiscip Rev RNA. 2011 Jul-Aug;2(4):471-92
references: 21957038
references: RNA Biol. 2014;11(1):18-24
references: 24384674
references: Cell. 2005 Aug 26;122(4):553-63
references: 16122423
references: Science. 2012 Aug 24;337(6097):980-4
references: 22859820
references: Neural Dev. 2012 Feb 07;7:7
references: 22314215