title: TRPA1 as a drug target--promise and challenges.
abstract: The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel belonging to the superfamily of transient receptor potential (TRP) channels. It is predominantly expressed in sensory neurons and serves as an irritant sensor for a plethora of electrophilic compounds. Recent studies suggest that TRPA1 is involved in pain, itch, and respiratory diseases, and TRPA1 antagonists have been actively pursued as therapeutic agents. Here, we review the recent progress, unsettled issues, and challenges in TRPA1 research and drug discovery.
authors: Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, 94080, USA, chenj144@gene.com.
authors: Jun
authors: J
authors: Chen
authors: David H
authors: DH
authors: Hackos
mesh_terms: D000818:Animals; D006801:Humans; D050051:Transient Receptor Potential Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels
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