title: Analgesic and anti-inflammatory activities of bupropion in animal models.
abstract: Antidepressants are widely used for the treatment of various neuropathic pain conditions in humans. Recent studies have demonstrated that bupropion is effective for the treatment of neuropathic pain. Also antidepressants like bupropion showed anti-inflammatory properties. So in the present study, the analgesic and anti-inflammatory effects of bupropion in mice and rat were investigated. The acetic acid, formalin and hot plate tests were used in male mice to assess analgesic activity. For evaluation of anti-inflammatory effect, carrageenan-induced rat paw edema and croton oil-induced ear edema were used. Bupropion was administered at the doses of 10, 20 and 40 mg/kg (i.p.). Bupropion at a dose of 40 mg/kg significantly reduced acetic acid-induced abdominal writhes and also was effective in suppression of formalin-induced behavior and showed significant analgesia in hot plate test. While 40 mg/kg bupropion showed considerable anti-inflammatory response in carrageenan test, but no effect was observed in croton oil-induced ear edema. The results showed that bupropion has analgesic and anti-inflammatory effects in animal models and further studies are needed to find out its mechanism of action.
authors: Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan university of Medical Sciences, Isfahan, I.R. Iran.
authors: V
authors: V
authors: Hajhashemi
authors: Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan university of Medical Sciences, Isfahan, I.R. Iran.
authors: P
authors: P
authors: Khanjani
keywords: Analgesic; Animal models; Anti-inflammatory; Antidepressants; Bupropion
references: Respir Res. 2007 May 03;8:35
references: 17477857
references: Science. 1984 Aug 17;225(4663):743-5
references: 6087456
references: Pain. 1987 Jul;30(1):103-14
references: 3614974
references: J Clin Psychiatry. 1994 Aug;55(8):362
references: 8071306
references: Anesthesiol Clin. 2007 Dec;25(4):775-86, vi
references: 18054144
references: Pharmacol Res. 2003 Aug;48(2):157-65
references: 12798668
references: Psychiatry (Edgmont). 2008 Dec;5(12):16-9
references: 19724772
references: Gastroenterology. 2001 Nov;121(5):1260-1
references: 11706830
references: Pharmacol Biochem Behav. 1998 Feb;59(2):331-8
references: 9476978
references: Actas Esp Psiquiatr. 2011;39 Suppl 1:1-25
references: 22983817
references: J Pathol. 1971 May;104(1):15-29
references: 4398139
references: Gen Hosp Psychiatry. 2003 Nov-Dec;25(6):495-6
references: 14706417
references: Eur J Pharmacol. 1980 Jan 11;61(1):17-24
references: 7353582
references: Proc Soc Exp Biol Med. 1962 Dec;111:544-7
references: 14001233
references: Pain. 1992 Oct;51(1):5-17
references: 1454405
references: Exp Dermatol. 2012 Jan;21(1):32-7
references: 22151388
references: Br J Pharmacol. 2011 Jun;163(4):792-803
references: 21371007
references: Int Immunopharmacol. 2006 Jun;6(6):903-7
references: 16644475
references: Int J Biochem Cell Biol. 2009 Nov;41(11):2098-108
references: 19497387
references: Neurology. 2001 Nov 13;57(9):1583-8
references: 11706096
references: J Psychiatry Neurosci. 2001 Jan;26(1):21-9
references: 11212590
references: Clin J Pain. 2000 Mar;16(1):6-11
references: 10741812
references: Anaesthesia. 1993 Apr;48(4):281-5
references: 8494126
references: Int Immunopharmacol. 2013 Mar;15(3):505-10
references: 23415748
references: Res Pharm Sci. 2012 Jan;7(1):37-42
references: 23181078
references: J Am Coll Cardiol. 2013 Feb 5;61(5):524-32
references: 23369417
references: Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409
references: 15910402
references: Expert Rev Neurother. 2006 Sep;6(9):1249-65
references: 17009913
references: Am J Hosp Palliat Care. 2010 Aug;27(5):333-6
references: 20185402