title: Lipid changes throughout pregnancy according to pre-pregnancy BMI: results from a prospective cohort.
abstract: OBJECTIVE
  To evaluate the rate of change in serum lipids and the factors associated with their variations, stratifying for pre-pregnancy body mass index (BMI) categories.
  
  
  METHODS
  Prospective cohort.
  
  
  METHODS
  Public Health centre, Rio de Janeiro, Brazil.
  
  
  METHODS
  Two hundred and twenty-five healthy pregnant women recruited between 2009 and 2011.
  
  
  METHODS
  Women were evaluated during the three trimesters of pregnancy (5th-13th, 20th-26th and 30th-36th gestational weeks). Pre-pregnancy BMI (kg/m²) was classified as normal weight (NW = 18.5-24.9), overweight (OW = 25.0-29.9) or obese (OB ≥ 30.0). The independent variables included maternal socioeconomic, demographic, biochemical and lifestyle factors. We performed linear mixed-effects models adjusted for gestational age and body weight, reporting coefficient (β) and 95% confidence interval (95% CI).
  
  
  METHODS
  Longitudinal total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c) and triglyceride (TG) measurements.
  
  
  RESULTS
  OW and OB women presented higher mean TG, TC and LDL-c compared with their NW counterparts (P < 0.05). The mean HDL-c concentrations were higher in NW than in OB women (P = 0.03). OW and OB women presented lower serum TC (βOW  = -0.014; 95% CI = -0.026 to -0.002; P = 0.022; βOB  = -0.015; 95% CI -0.015 to 0.001; P = 0.066) and LDL-c (βOW  = -0.012; 95% CI = -0.021 to -0.002; P = 0.017; βOB  = -0.018; 95% CI = -0.031 to -0.005; P = 0.005) rates of change (mmol/l per gestational week) compared with the NW. Pre-gestational BMI was the main factor associated with the rate of changes in TC and LDL-c concentrations.
  
  
  CONCLUSIONS
  Pre-pregnancy BMI was the main factor associated with the rate of change in TC and LDL-c throughout pregnancy, and OW and OB women presented lower rates of change compared with NW controls.
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.|Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: D R
authors: DR
authors: Farias
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.|Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: A B
authors: AB
authors: Franco-Sena
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.|Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: Aaf
authors: A
authors: Vilela
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.|Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: J
authors: J
authors: Lepsch
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: R H
authors: RH
authors: Mendes
authors: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
authors: G
authors: G
authors: Kac
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008019:Life Style; D052439:Lipid Metabolism Disorders / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D037841:Pregnant People; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: Body mass index; lipids; obesity; pregnancy