title: Role of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene and risk of esophageal cancer in the Kashmiri population.
abstract: BACKGROUND
  The gene for the vascular endothelial growth factor (VEGF), which promotes angiogenesis and permeability, is polymorphic. The aim of the present study was to evaluate the relationship between +936C>T and +404C>G polymorphism of VEGF with risk of esophageal cancer in the Kashmiri population in India.
  
  
  METHODS
  150 esophageal cancer patients and 150 unrelated healthy controls were genotyped for two VGEF SNPs (+405C/G, and +936C/T) using DNA extracted from prospectively collected blood samples by the PCR-RFLP method.
  
  
  RESULTS
  For the VEGF +936C>T polymorphism a significant association of CT and combined CT+TT genotypes was observed with increased risk of esophageal cancer (p=0.021; 0.024). For the +405C>G polymorphism we observed significantly increased frequency of GG genotype in cases as compared to controls and also the +405 GG Genotype was observed to have a two fold risk(OR=2.7356; 95%CI=1.1409- 6.5593; p=0.020). The combined genotypes of GG-CC and GG-CT of +405C>G and +936C>T were found to be significantly associated with increased risk of esophageal cancer (p=0.0376; 0.0099).
  
  
  CONCLUSIONS
  From the results of the present study a significant association of +936C>T and +405C>G polymorphisms with increased esophageal cancer risk exists in the Kashmiri population.
authors: Department of Immunology and Molecular Medicine Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India E-mail : zaff aramin@gmail.com.
authors: Iqbal
authors: I
authors: Qasim
authors: Imtiyaz Ahmad
authors: IA
authors: Bhat
authors: Khalid Zafar
authors: KZ
authors: Masoodi
authors: Zafar Amin
authors: ZA
authors: Shah
mesh_terms: D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India / Q000453:epidemiology; D009389:Neovascularization, Pathologic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A