title: Rapid monitoring of benzylpenicillin sodium using Raman and surface enhanced Raman spectroscopy.
abstract: At present, fluorescence spectroscopy, ultraviolet spectroscopy and infrared spectroscopy are usually used to detect drug molecules, however the information about using Raman spectroscopy to detect drug molecules is very few. In this work normal Raman spectroscopy and surface-enhanced Raman spectroscopy were utilized to study benzylpenicillin sodium (NaBP). The results show that NaBP is close to the surface of silver substrate through the carboxyl group, and the detection limit of NaBP is reduced to 1×10(-7) mol/L. Accordingly, the quantitative analysis of NaBP can be carried out in the range of 1×10(-4)-1×10(-7) mol/L concentration. And it is proved that NaBP is not stable in acid and alkali conditions and the decomposition reaction is very complex.
authors: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People's Republic of China; College of Pharmacy, Jiamusi University, Jiamusi 154007, People's Republic of China.
authors: Xin
authors: X
authors: Jiang
authors: College of Pharmacy, Jiamusi University, Jiamusi 154007, People's Republic of China.
authors: Xiaoyu
authors: X
authors: Qin
authors: College of Pharmacy, Jiamusi University, Jiamusi 154007, People's Republic of China.
authors: Di
authors: D
authors: Yin
authors: College of Pharmacy, Jiamusi University, Jiamusi 154007, People's Republic of China.
authors: Mengdi
authors: M
authors: Gong
authors: College of Pharmacy, Jiamusi University, Jiamusi 154007, People's Republic of China. Electronic address: ylb76@163.com.
authors: Libin
authors: L
authors: Yang
authors: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People's Republic of China. Electronic address: zhaob@mail.jlu.edu.cn.
authors: Bing
authors: B
authors: Zhao
authors: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People's Republic of China.
authors: Weidong
authors: W
authors: Ruan
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D003102:Colloids / Q000737:chemistry; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010400:Penicillin G / Q000032:analysis*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D003102:Colloids; D012834:Silver; D010400:Penicillin G
keywords: Benzylpenicillin sodium (NaBP); Raman spectroscopy; SERS; Silver colloid