title: Granulomatous reaction to liquid injectable silicone for gluteal enhancement: review of management options and success of doxycycline.
abstract: Liquid injectable silicone (LIS) for cosmetic purposes has been widely available and commonly used for almost half a century. An increase in buttock augmentation procedures because of patients wanting to emulate the look of some celebrities has recently highlighted cases in the media of unsafe administration of liquid silicone injections. Severe complications including death have been reported. In this article, we report a case in which liquid silicone was injected in the patient's gluteal tissue resulting in granulomatous reactions in the surrounding tissues. The patient responded well to doxycycline, presumably because of both its antimicrobial properties and immunomodulatory effects.
authors: Harvard Medical School, Boston, Massachusetts.
authors: Suchismita
authors: S
authors: Paul
authors: Amrita
authors: A
authors: Goyal
authors: Lyn M
authors: LM
authors: Duncan
authors: Gideon P
authors: GP
authors: Smith
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001706:Biopsy; D002081:Buttocks; D003357:Cosmetic Techniques / Q000009:adverse effects*; D000067548:Dermal Fillers / Q000008:administration & dosage / Q000009:adverse effects*; D004318:Doxycycline / Q000627:therapeutic use*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D012307:Risk Factors; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000067548:Dermal Fillers; D012828:Silicones; D004318:Doxycycline
keywords: doxycycline; granuloma; liquid silicone; mycobacterial infection