title: G-CSF as an adjunctive therapy with umbilical cord blood cell transplantation for traumatic brain injury.
abstract: Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma. Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy. The efficacy of stem cell-based interventions, as well as neuroprotective agents in other neurological disorders of which pathologies overlap with TBI, indicates their potential as alternative TBI treatments. Furthermore, their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent. Indeed, we demonstrated remarkable combined efficacy of human umbilical cord blood (hUCB) cell therapy and granulocyte-colony-stimulating factor (G-CSF) treatment in TBI models, providing essential evidence for the translation of this approach to treat TBI. Further studies are warranted to determine the mechanisms underlying therapeutic benefits exerted by hUCB + G-CSF in order to enhance its safety and efficacy in the clinic.
authors: Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
authors: Ike
authors: I
authors: De La Peña
authors: Paul R
authors: PR
authors: Sanberg
authors: Sandra
authors: S
authors: Acosta
authors: Shinn-Zong
authors: SZ
authors: Lin
authors: Cesar V
authors: CV
authors: Borlongan
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D005312:Fetal Blood / Q000166:cytology*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor