title: Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease.
abstract: Parkinson's disease (PD) is a degenerative disorder of the central nervous system and is characterized by motor system disorders resulting in loss of dopamine producing brain cells. Acidic fibroblast growth factor, also called FGF1, promotes the survival of neurons. The aims of the present study were to confirm FGF1 could protect neurons cultures from 6-hydroxydopamine (6-OHDA) toxicity in vitro and in vivo. Our results demonstrated FGF1 administration improved the motor function recovery, increased the TH-positive neurons survival and up-regulated the levels of neurotransmitters in PD rats. Meanwhile, FGF1 prevents the death of DA neuron at least in part by reducing the levels of α-synuclein and ER stress. The administration of FGF1 activated downstream signals PI3K/Akt and ERK1/2. In conclusion, FGF1 diminished α-synuclein neurotoxicity by down regulating ER stress mediators and the level of apoptosis, and these effects may underlying the activation of the PI3K/Akt and ERK1/2 signal pathway.
authors: Department of Neurosurgery, Cixi People's Hospital, Wenzhou Medical University Ningbo, Zhejiang, 315300, PR China.
authors: Xiaojie
authors: X
authors: Wei
authors: Department of Neurology, Zhoushan Hospital, Wenzhou Medical University Zhoushan, Zhejiang, 316000, PR China.
authors: Songbin
authors: S
authors: He
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Zhouguang
authors: Z
authors: Wang
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Jiamin
authors: J
authors: Wu
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Jinjing
authors: J
authors: Zhang
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Yi
authors: Y
authors: Cheng
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Jie
authors: J
authors: Yang
authors: Department of Neurosurgery, Cixi People's Hospital, Wenzhou Medical University Ningbo, Zhejiang, 315300, PR China.
authors: Xinlong
authors: X
authors: Xu
authors: Department of Neurosurgery, Cixi People's Hospital, Wenzhou Medical University Ningbo, Zhejiang, 315300, PR China.
authors: Zaifeng
authors: Z
authors: Chen
authors: Department of Anesthesia, The First Affiliated Hospital, Gangnan Medical University Ganzhou, Jiangxi, 341000, China.
authors: Junmin
authors: J
authors: Ye
authors: Department of Anesthesia, The First Affiliated Hospital, Gangnan Medical University Ganzhou, Jiangxi, 341000, China.
authors: Li
authors: L
authors: Chen
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Li
authors: L
authors: Lin
authors: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University Wenzhou, Zhejiang, 325035, China.
authors: Jian
authors: J
authors: Xiao
keywords: ER stress; FGF1; parkinson’s disease; α-synuclein
references: J Neurochem. 2005 Nov;95(4):974-86
references: 16135078
references: Neurosci Res. 2012 Jan;72(1):1-8
references: 21946416
references: J Biol Chem. 2003 Aug 1;278(31):29317-26
references: 12738790
references: Cytokine Growth Factor Rev. 2011 Jun;22(3):157-65
references: 21689963
references: Int J Biochem Cell Biol. 2012 Aug;44(8):1295-8
references: 22564438
references: Toxicol Lett. 2012 Jul 20;212(2):137-46
references: 22609091
references: CNS Neurosci Ther. 2013 Sep;19(9):688-94
references: 23710708
references: J Neurosurg Spine. 2011 Sep;15(3):216-27
references: 21663406
references: Neuropharmacology. 2011 Jul-Aug;61(1-2):252-61
references: 21527262
references: J Biol Chem. 2002 Feb 15;277(7):5411-7
references: 11724769
references: FASEB J. 2004 Apr;18(6):617-26
references: 15054084
references: Parkinsonism Relat Disord. 1998 Oct;4(3):147-58
references: 18591105
references: Neurotox Res. 2000;2(2-3):115-37
references: 16787836
references: Am J Transl Res. 2012;4(1):102-13
references: 22347525
references: Mol Neurobiol. 2015;51(3):1343-52
references: 25048984
references: Biochim Biophys Acta. 2013 Dec;1833(12):3460-70
references: 23850759
references: J Neurosci. 2012 Mar 7;32(10):3301-5
references: 22399752
references: Trends Mol Med. 2010 Jan;16(1):27-36
references: 20036196
references: Neuroscience. 2014 Jun 13;270:183-91
references: 24755484
references: J Neurosci. 2002 Dec 15;22(24):10690-8
references: 12486162
references: Biomed Res Int. 2014;2014:807874
references: 24900988
references: Curr Opin Neurobiol. 1994 Feb;4(1):78-86
references: 8173328
references: Stereotact Funct Neurosurg. 1990;54-55:250-67
references: 2080339
references: Mol Ther. 2012 Jul;20(7):1327-37
references: 22434142
references: Neurol Sci. 2013 Feb;34(2):259-61
references: 22382742
references: J Pharm Biomed Anal. 2013 Jan;72:74-9
references: 23146229
references: Parkinsonism Relat Disord. 2007;13 Suppl 3:S321-8
references: 18267258
references: CNS Neurosci Ther. 2013 Jan;19(1):20-9
references: 23082997
references: Trends Mol Med. 2013 Mar;19(3):165-75
references: 23352769
references: Am J Transl Res. 2010 Jan 01;2(1):19-42
references: 20182580
references: Brain Res. 1990 Aug 27;526(1):156-60
references: 1706636
references: J Neurosci. 2007 Jan 17;27(3):459-71
references: 17234579
references: Nat Rev Drug Discov. 2009 Mar;8(3):235-53
references: 19247306
references: J Biol Chem. 2003 May 23;278(21):19367-77
references: 12598533
references: J Neurochem. 2011 Feb;116(4):588-605
references: 21166675
references: Behav Brain Res. 2006 Apr 25;169(1):1-9
references: 16413939
references: Brain Res Dev Brain Res. 1993 Sep 17;75(1):65-73
references: 7693370
references: J Comp Neurol. 2012 Dec 1;520(17):3949-61
references: 22592787
references: J Neurosci. 2012 Mar 7;32(10):3306-20
references: 22399753
references: J Neurosurg Spine. 2008 Mar;8(3):208-14
references: 18312071