title: Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia.
abstract: The corpus callosum has been implicated as a region of dysfunctional connectivity in schizophrenia, but the association between age and callosal pathology is unclear. Magnetic resonance imaging (MRI) and diffusion-tensor imaging (DTI) were performed on adults (n=34) and adolescents (n=17) with schizophrenia and adult (n=33) and adolescent (n=15) age- and sex-matched healthy controls. The corpus callosum was manually traced on each participant׳s MRI, and the DTI scan was co-registered to the MRI. The corpus callosum was divided into five anteroposterior segments. Area and anisotropy were calculated for each segment. Both patient groups demonstrated reduced callosal anisotropy; however, the adolescents exhibited reductions mostly in anterior regions while the reductions were more prominent in posterior regions of the adults. The adolescent patients showed greater decreases in absolute area as compared with the adult patients, particularly in the anterior segments. However, the adults showed greater reductions when area was considered relative to whole brain white matter volume. Our results suggest that the initial stages of the illness are characterized by deficiencies in frontal connections, and the chronic phase is characterized by deficits in the posterior corpus callosum; or, alternatively, adolescent-onset schizophrenia may represent a different or more severe form of the illness.
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate Center, City University of New York, New York, NY 10016, USA.
authors: Emily C
authors: EC
authors: Balevich
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Outpatient Psychiatry Care Center, James J. Peters VA Medical Center, Bronx, NY 10468, USA.
authors: M Mehmet
authors: MM
authors: Haznedar
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Eugene
authors: E
authors: Wang
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Randall E
authors: RE
authors: Newmark
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Rachel
authors: R
authors: Bloom
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Jason S
authors: JS
authors: Schneiderman
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Jonathan
authors: J
authors: Aronowitz
authors: Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Cheuk Y
authors: CY
authors: Tang
authors: Research and Development and VISN 3 Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY 10468, USA.
authors: King-Wai
authors: KW
authors: Chu
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Outpatient Psychiatry Care Center, James J. Peters VA Medical Center, Bronx, NY 10468, USA; Research and Development and VISN 3 Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY 10468, USA.
authors: William
authors: W
authors: Byne
authors: Departments of Psychiatry and Radiology, University of California, San Diego School of Medicine, 92093, USA.
authors: Monte S
authors: MS
authors: Buchsbaum
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Research and Development and VISN 3 Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY 10468, USA. Electronic address: erin.hazlett@mssm.edu.
authors: Erin A
authors: EA
authors: Hazlett
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001931:Brain Mapping / Q000379:methods; D003337:Corpus Callosum / Q000378:metabolism* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
keywords: Diffusion tensor imaging; Magnetic resonance imaging (MRI); Schizophrenia spectrum; White matter
references: BMC Psychiatry. 2014;14:99
references: 24693962
references: Neuroimage. 2011 Feb 14;54(4):2557-62
references: 21087671
references: Am J Psychiatry. 2008 Aug;165(8):1024-32
references: 18558643
references: Psychiatry Res. 2009 Nov 30;174(2):110-5
references: 19853414
references: Schizophr Res. 2009 Mar;108(1-3):41-8
references: 19103476
references: Cereb Cortex. 2013 Oct;23(10):2514-20
references: 22891036
references: Br J Psychiatry. 1983 Mar;142:284-7
references: 6860881
references: Brain. 2010 May;133(Pt 5):1494-504
references: 20237131
references: Schizophr Res. 2000 May 5;42(3):193-208
references: 10785578
references: Curr Opin Psychiatry. 2009 Mar;22(2):168-76
references: 19553871
references: Br J Psychiatry. 2008 Jun;192(6):429-34
references: 18515892
references: Radiology. 2001 Apr;219(1):101-7
references: 11274543
references: Biol Psychiatry. 2008 Mar 1;63(5):519-23
references: 17662964
references: Neuroimage. 2006 Sep;32(3):989-94
references: 16854598
references: Psychiatry Res. 2010 Mar 30;181(3):193-8
references: 20153608
references: Schizophr Res. 2009 Oct;114(1-3):144-53
references: 19713080
references: Schizophr Res. 2005 Jun 15;75(2-3):265-81
references: 15885518
references: Neuroimage. 2010 Jan 1;49(1):199-204
references: 19619664
references: Schizophr Res. 1998 Mar 10;30(2):111-4
references: 9549773
references: Schizophr Res. 2008 Apr;101(1-3):124-32
references: 18289833
references: Schizophr Res. 2007 May;92(1-3):211-24
references: 17329081
references: J Psychiatry Neurosci. 2011 Mar;36(2):120-5
references: 21138657
references: Am J Psychiatry. 2003 Dec;160(12):2154-68
references: 14638586
references: J Comp Neurol. 1968 Jan;132(1):45-72
references: 5293999
references: Biol Psychiatry. 1986 Mar;21(3):274-82
references: 3947709
references: Neuroimage. 2007 Apr 1;35(2):458-66
references: 17275337
references: Br J Psychiatry. 2014 Jan;204(1):55-60
references: 24202961
references: Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:117-23
references: 24099786
references: Psychol Med. 2008 Jun;38(6):877-85
references: 17949516
references: Br J Psychiatry. 1972 Sep;121(562):259-64
references: 5073779
references: J Nerv Ment Dis. 2004 Sep;192(9):615-22
references: 15348978
references: Schizophr Res. 2005 Jan 1;72(2-3):91-108
references: 15560955
references: Psychol Med. 1998 Mar;28(2):463-73
references: 9572103
references: Neuroimage. 2005 Oct 1;27(4):753-70
references: 15990338
references: Neuropsychobiology. 2007;55(2):96-111
references: 17587876
references: Psychophysiology. 1998 Mar;35(2):186-98
references: 9529945
references: Neurosci Lett. 2012 Apr 4;513(2):178-82
references: 22373786
references: Am J Psychiatry. 2000 Oct;157(10):1652-9
references: 11007720
references: Am J Psychiatry. 2005 Sep;162(9):1733-5
references: 16135634
references: Br J Psychiatry. 1990 Feb;156:216-27
references: 2317626
references: Neurosci Lett. 2002 Mar 1;320(1-2):57-60
references: 11849763
references: J Int Neuropsychol Soc. 2007 Sep;13(5):893-7
references: 17697420
references: Brain. 2007 Sep;130(Pt 9):2375-86
references: 17698497
references: Neuroimage. 2008 Feb 15;39(4):1522-32
references: 18096406
references: Schizophr Res. 2008 Aug;103(1-3):1-10
references: 18562178
references: Schizophr Res. 2006 Oct;87(1-3):138-59
references: 16854563
references: Neurobiol Dis. 2006 Jun;22(3):702-9
references: 16624566
references: Neuropsychobiology. 2014;69(1):52-8
references: 24457222
references: J Psychiatry Neurosci. 2008 May;33(3):235-43
references: 18592042
references: Schizophr Res. 1996 May;20(1-2):57-68
references: 8794494
references: Nat Neurosci. 1999 Oct;2(10):859-61
references: 10491602
references: Schizophr Res. 2000 Dec 15;46(2-3):231-9
references: 11120435
references: Transl Psychiatry. 2012;2:e190
references: 23168990
references: J Comput Assist Tomogr. 1993 Jul-Aug;17(4):536-46
references: 8331222
references: Schizophr Res. 2000 May 25;43(1):33-46
references: 10828413
references: Ann Gen Psychiatry. 2006 Nov 28;5:19
references: 17132158
references: Neuroimage. 2009 Apr 15;45(3):662-71
references: 19168139
references: Psychiatry Res. 2014 Aug 30;223(2):148-56
references: 24909602