title: Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy.
abstract: Stimuli-responsive nanosystems are of particular interest in cancer therapy, owing to their impressive capability to enable the on-demand drug release in response to specific biological stimuli in tumor microenvironments (such as pH, redox and enzyme, etc.). Cyclodextrin (CD)-based host-guest interactions provide a flexible and powerful platform for the development of multifunctional nanosystems. This article highlights the current progress of CD-based host-guest nanosystems (CHNs) with biological stimuli-responsive properties in cancer therapy. We summarize the composition, structure and design of various CHNs in response to specific stimuli in tumor, and focus on their performance in controlled drug delivery and cancer therapy. These recent advances make it a promising and intelligent drug delivery system to improve the anticancer efficacy.
authors: School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.
authors: Zhaoling
authors: Z
authors: Dan
authors: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Haiqiang
authors: H
authors: Cao
authors: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Xinyu
authors: X
authors: He
authors: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Lijuan
authors: L
authors: Zeng
authors: School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.
authors: Lili
authors: L
authors: Zou
authors: School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China. Electronic address: qshen@sjtu.edu.cn.
authors: Qi
authors: Q
authors: Shen
authors: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: zwzhang0125@simm.ac.cn.
authors: Zhiwen
authors: Z
authors: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins
keywords: Cancer therapy; Cyclodextrin; Drug delivery; Host–guest; Nanosystem; Stimuli-responsive