title: Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent.
abstract: This study aimed to produce and characterize an oil in water (O/W) nanoemulsion containing Opuntia ficus-indica (L.) Mill hydroglycolic extract, as well as evaluate its preliminary and accelerated thermal stability and moisturizing efficacy. The formulations containing 0.5% of xanthan gum (FX) and 0.5% of xanthan gum and 1% of Opuntia ficus-indica MILL extract (FXE) were white, homogeneus and fluid in aspect. Both formulations were stable during preliminary and accelerated stability tests. FX and FXE presented a pH compatible to skin pH (4.5-6.0); droplet size varying from 92.2 to 233.6 nm; a polydispersion index (PDI) around 0.200 and a zeta potential from -26.71 to -47.01 mV. FXE was able to increase the water content of the stratum corneum for 5 h after application on the forearm. The O/W nanoemulsions containing 1% of Opuntia ficus-indica (L.) Mill extract presented suitable stability for at least for 60 days. Besides, this formulation was able to increase the water content of stratum corneum, showing its moisturizing efficacy.
authors: College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil. recar_89@hotmail.com.
authors: Renato Cesar de Azevedo
authors: RC
authors: Ribeiro
authors: College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil. smagbarreto@gmail.com.
authors: Stella Maria de Andrade Gomes
authors: SM
authors: Barreto
authors: College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil. aranteselissa@gmail.com.
authors: Elissa Aarantes
authors: EA
authors: Ostrosky
authors: College of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Zeferino Vaz, s/n, Monte Alegre, Ribeirão Preto 14040-903, SP, Brazil. pedranjo@fcfrp.usp.br.
authors: Pedro Alves
authors: PA
authors: da Rocha-Filho
authors: College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil. lourenamafra@yahoo.com.br.
authors: Lourena Mafra
authors: LM
authors: Veríssimo
authors: College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil. ferrarimarcio@uol.com.br.
authors: Márcio
authors: M
authors: Ferrari
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003358:Cosmetics / Q000008:administration & dosage*; D004655:Emulsions; D006801:Humans; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage*; D029747:Opuntia / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D055815:Young Adult
chemical_list: D003358:Cosmetics; D004655:Emulsions; D009824:Ointments; D010936:Plant Extracts
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