title: Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens.
abstract: The aim of the study was to investigate whether adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZ® Phleum, ALK-Abelló) are related to the different patterns of sensitization of patients to grass allergens. A total of 192 patients with rhinitis and/or asthma sensitized to grass pollen received a 4-week updosing with five injections. ADRs were evaluated following EAACI guidelines. A total of 432 ADRs in 133 (69%) patients were recorded, 64% local and 31% systemic. There was a significant association between the number of grass allergens that sensitized the patients and the total number of ADRs (P = 0.004) occurred locally (P = 0.003) and systemically (P = 0.01). Sensitization to Phl p1 + Phl p5 or Phl p1 + Phl p5 + Phl p12 was significantly associated with a higher frequency of local or systemic reactions (P = 0.001, both). Different patterns of sensitization to grass allergens may potentially be considered a risk marker to the development of ADRs to immunotherapy.
authors: Allergy, Fundación Jimenez Díaz, Madrid, Spain.
authors: J
authors: J
authors: Sastre
authors: F
authors: F
authors: Rodríguez
authors: P
authors: P
authors: Campo
authors: E
authors: E
authors: Laffond
authors: A
authors: A
authors: Marín
authors: M D
authors: MD
authors: Alonso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D003888:Desensitization, Immunologic / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006109:Poaceae / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D055815:Young Adult
chemical_list: D000485:Allergens
keywords: grass allergens; immunotherapy; molecular diagnosis; safety