title: Noncoding RNA in age-related cardiovascular diseases.
abstract: Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (lnc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Collectively, ncRNAs affect a broad range of age-related physiologic deteriorations and pathologies, including reduced cardiovascular vigor and age-associated cardiovascular disease. This review presents an update of our understanding of regulatory ncRNAs contributing to cardiovascular health and disease as a function of advancing age. We will discuss (1) regulatory ncRNAs that control aging-associated cardiovascular homeostasis and disease, (2) the concepts, approaches, and methodologies needed to study regulatory ncRNAs in cardiovascular aging and (3) the challenges and opportunities that age-associated regulatory ncRNAs present in cardiovascular physiology and pathology. This article is part of a Special Issue entitled "CV Aging".
authors: Laboratory of Molecular Cardiology, Policlinico San Donato-IRCCS, Milan, 20097, Italy.
authors: Simona
authors: S
authors: Greco
authors: Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA. Electronic address: myriam-gorospe@nih.gov.
authors: Myriam
authors: M
authors: Gorospe
authors: Laboratory of Molecular Cardiology, Policlinico San Donato-IRCCS, Milan, 20097, Italy. Electronic address: fabio.martelli@grupposandonato.it.
authors: Fabio
authors: F
authors: Martelli
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D003324:Coronary Artery Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009203:Myocardial Infarction / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Aging; Cardiovascular disease; Long noncoding RNA; MicroRNA
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