title: Electrospun polyamide 6/poly(allylamine hydrochloride) nanofibers functionalized with carbon nanotubes for electrochemical detection of dopamine.
abstract: The use of nanomaterials as an electroactive medium has improved the performance of bio/chemical sensors, particularly when synergy is reached upon combining distinct materials. In this paper, we report on a novel architecture comprising electrospun polyamide 6/poly(allylamine hydrochloride) (PA6/PAH) nanofibers functionalized with multiwalled carbon nanotubes, used to detect the neurotransmitter dopamine (DA). Miscibility of PA6 and PAH was sufficient to form a single phase material, as indicated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), leading to nanofibers with no beads onto which the nanotubes could adsorb strongly. Differential pulse voltammetry was employed with indium tin oxide (ITO) electrodes coated with the functionalized nanofibers for the selective electrochemical detection of dopamine (DA), with no interference from uric acid (UA) and ascorbic acid (AA) that are normally present in biological fluids. The response was linear for a DA concentration range from 1 to 70 μmol L(-1), with detection limit of 0.15 μmol L(-1) (S/N = 3). The concepts behind the novel architecture to modify electrodes can be potentially harnessed in other electrochemical sensors and biosensors.
authors: National Laboratory for Nanotechnology in Agribusiness (LNNA), Embrapa Instrumentation , 13560-970 São Carlos, São Paulo, Brazil.
authors: Luiza A
authors: LA
authors: Mercante
authors: Adriana
authors: A
authors: Pavinatto
authors: Leonardo E O
authors: LE
authors: Iwaki
authors: Vanessa P
authors: VP
authors: Scagion
authors: Valtencir
authors: V
authors: Zucolotto
authors: Osvaldo N
authors: ON
authors: Oliveira
authors: Luiz H C
authors: LH
authors: Mattoso
authors: Daniel S
authors: DS
authors: Correa
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D015374:Biosensing Techniques; D002152:Calorimetry, Differential Scanning; D002209:Caprolactam / Q000031:analogs & derivatives / Q000737:chemistry; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques; D004566:Electrodes; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013818:Thermogravimetry; D017971:Tin Compounds / Q000737:chemistry; D014527:Uric Acid / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D011073:Polyamines; D011108:Polymers; D017971:Tin Compounds; C009916:nylon 6; D014527:Uric Acid; C063994:polyallylamine; D002209:Caprolactam; C109984:indium tin oxide; D001205:Ascorbic Acid; D004298:Dopamine
keywords: carbon nanotube; dopamine; electrospinning; nanofibers; sensor