title: Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.
abstract: Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary artery disease (CAD) and Parkinson's disease (PD). Multifactor dimensionality reduction analysis was carried out on four case-control datasets. Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5'-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). Gene-gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A). These interaction models showed good predictability of risk for PD (The area under the receiver operating characteristic curve (C) = 0.83) and SLE (C = 0.73); and moderate predictability of risk for breast cancer (C = 0.64) and CAD (C = 0.63). Cross-talk between one-carbon and xenobiotic pathways was observed in diseases with female preponderance. Gene-gene interactions within one-carbon metabolic pathway were observed in diseases with male preponderance.
authors: School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India, naushadsm@gmail.com.
authors: Shaik Mohammad
authors: SM
authors: Naushad
authors: Sana Venkata
authors: SV
authors: Vijayalakshmi
authors: Yedluri
authors: Y
authors: Rupasree
authors: Nadella
authors: N
authors: Kumudini
authors: Sampathkumar
authors: S
authors: Sowganthika
authors: Janardhanan Venketlakshmi
authors: JV
authors: Naidu
authors: M Janaki
authors: MJ
authors: Ramaiah
authors: Dunna Nageswara
authors: DN
authors: Rao
authors: Vijay Kumar
authors: VK
authors: Kutala
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002244:Carbon / Q000378:metabolism; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D066264:Datasets as Topic; D004843:Epistasis, Genetic; D005163:Factor Analysis, Statistical; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D058011:Multifactor Dimensionality Reduction; D010088:Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D014166:Transferases / Q000235:genetics* / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D015262:Xenobiotics; D002244:Carbon; D010088:Oxidoreductases; D014166:Transferases
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