title: Cardiovascular safety of the glucagon-like peptide-1 receptor agonist taspoglutide in people with type 2 diabetes: an individual participant data meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To study the short-term cardiovascular effects of the once-weekly glucagon-like peptide-1 receptor agonist taspoglutide.
  
  
  METHODS
  We conducted a meta-analysis of individual-participant data from nine randomized controlled trials in the T-Emerge programme, which assessed the efficacy and safety of taspoglutide in type 2 diabetes. Our primary outcome was a composite of death from cardiovascular disease (CVD) and acute myocardial infarction, stroke and hospitalization for unstable angina.
  
  
  RESULTS
  Overall, 7056 individuals were included in the analysis, and there were 67 primary endpoint events during 7478 person-years of follow-up (40 vs 27 events in the intervention vs control groups, respectively). The odds ratio for the composite endpoint among people randomized to taspoglutide was 0.94 (95% confidence interval 0.57-1.56), which was robust across multiple subgroups. Longer-term data were not available as the development of taspoglutide was stopped because of gastrointestinal intolerance and serious hypersensitivity reactions.
  
  
  CONCLUSIONS
  The available data suggest that short-term, once-weekly administration of taspoglutide was not associated with an excess risk of CVD, and provide insights relevant to the development of other novel once-weekly incretin mimetics.
authors: Cardiovascular and Cell Sciences Research Institute, St George's, University of London, London, UK.
authors: S R K
authors: SR
authors: Seshasai
authors: R L
authors: RL
authors: Bennett
authors: J R
authors: JR
authors: Petrie
authors: M
authors: M
authors: Bengus
authors: S
authors: S
authors: Ekman
authors: M
authors: M
authors: Dixon
authors: M
authors: M
authors: Herz
authors: J B
authors: JB
authors: Buse
authors: K K
authors: KK
authors: Ray
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology*; D017326:Clinical Trials, Phase III as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D000067757:Glucagon-Like Peptide-1 Receptor / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D000067757:Glucagon-Like Peptide-1 Receptor; D010455:Peptides; C541736:taspoglutide; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
keywords: GLP-1 receptor agonists; cardiovascular safety; diabetes; meta-analysis; taspoglutide