title: Placental extracellular vesicles and feto-maternal communication.
abstract: The human placenta is an anatomically unique structure that extrudes a variety of extracellular vesicles into the maternal blood (including syncytial nuclear aggregates, microvesicles, and nanovesicles). Large quantities of extracellular vesicles are produced by the placenta in both healthy and diseased pregnancies. Since their first description more than 120 years ago, placental extracellular vesicles are only now being recognized as important carriers for proteins, lipids, and nucleic acids, which may play a crucial role in feto-maternal communication. Here, we summarize the current literature on the cargos of placental extracellular vesicles and the known effects of such vesicles on maternal cells/systems, especially those of the maternal immune and vascular systems.
authors: Department of Obstetrics and Gynecology, University of Auckland, Grafton, Auckland 1142, New Zealand.
authors: M
authors: M
authors: Tong
authors: Department of Obstetrics and Gynecology, University of Auckland, Grafton, Auckland 1142, New Zealand.
authors: L W
authors: LW
authors: Chamley
mesh_terms: D000067128:Extracellular Vesicles / Q000502:physiology*; D005260:Female; D006801:Humans; D008055:Lipids; D008431:Maternal-Fetal Exchange / Q000276:immunology; D009696:Nucleic Acids; D010920:Placenta / Q000502:physiology*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D008055:Lipids; D009696:Nucleic Acids
references: PLoS One. 2014 Feb 27;9(2):e90020
references: 24587192
references: PLoS One. 2011;6(10):e26313
references: 22022598
references: Placenta. 2009 Oct;30(10):891-7
references: 19692120
references: Placenta. 2012 Nov;33(11):933-41
references: 22999499
references: Mol Hum Reprod. 2005 Jan;11(1):35-41
references: 15579659
references: J Immunol. 2007 May 1;178(9):5949-56
references: 17442979
references: Placenta. 2008 Nov;29(11):942-9
references: 18834630
references: Eur J Obstet Gynecol Reprod Biol. 2009 Jul;145(1):22-6
references: 19410360
references: Eur J Obstet Gynecol Reprod Biol. 1975;5(1-2):35-46
references: 1053576
references: PLoS One. 2011;6(5):e20245
references: 21633494
references: Placenta. 2010 Feb;31(2):106-12
references: 20005571
references: Reprod Sci. 2008 Dec;15(10):1002-10
references: 18936439
references: Am J Obstet Gynecol. 2004 Jan;190(1):252-8
references: 14749668
references: Br J Obstet Gynaecol. 1998 Jun;105(6):632-40
references: 9647154
references: Hypertension. 2006 Jan;47(1):116-21
references: 16344369
references: J Clin Invest. 2003 Mar;111(5):649-58
references: 12618519
references: Placenta. 2008 Sep;29(9):826-32
references: 18684502
references: J Cell Biol. 2013 Feb 18;200(4):373-83
references: 23420871
references: Clin Exp Immunol. 1982 Apr;48(1):279-87
references: 6177463
references: Hypertension. 2012 Feb;59(2):256-64
references: 22215706
references: Placenta. 2014 Oct;35(10):839-47
references: 25096950
references: Biochim Biophys Acta. 2014 Jan;1841(1):108-20
references: 24140720
references: Placenta. 2012 Jul;33(7):548-53
references: 22504042
references: Arch Gynecol Obstet. 2008 Feb;277(2):115-9
references: 17653562
references: Hum Reprod. 1999 Apr;14(4):919-24
references: 10221219
references: J Reprod Immunol. 2005 Dec;68(1-2):15-26
references: 16233919
references: Am J Reprod Immunol. 2011 Jan;65(1):65-77
references: 20560914
references: J Thromb Haemost. 2009 Jun;7(6):1047-50
references: 19320826
references: J Transl Med. 2011 Jun 08;9:86
references: 21651777
references: Cell Immunol. 1992 Jan;139(1):259-67
references: 1309491
references: J Immunol. 1986 Aug 15;137(4):1187-93
references: 3016089
references: Am J Pathol. 2012 Jan;180(1):256-66
references: 22079431
references: Virchows Arch. 2008 Oct;453(4):387-400
references: 18791734
references: PLoS One. 2013;8(2):e56754
references: 23437230
references: Biochem Soc Trans. 2011 Apr;39(2):559-62
references: 21428939
references: Placenta. 2011 Jan;32(1):63-9
references: 21074265
references: Hum Immunol. 2005 Nov;66(11):1146-54
references: 16571415
references: J Pathol. 2009 Jan;217(1):122-30
references: 18825657
references: Fetal Diagn Ther. 2007;22(4):313-7
references: 17361087
references: Hypertens Pregnancy. 2008;27(4):344-60
references: 19003636
references: J Immunol. 2013 Dec 1;191(11):5515-23
references: 24184557
references: J Reprod Immunol. 2008 Oct;79(1):12-7
references: 18715652
references: Am J Pathol. 2008 Dec;173(6):1595-608
references: 18974299
references: Hum Reprod Update. 2005 Jan-Feb;11(1):59-67
references: 15569699
references: Mol Hum Reprod. 2012 Aug;18(8):417-24
references: 22383544
references: Br J Obstet Gynaecol. 1991 Oct;98(10):973-9
references: 1751443
references: J Immunol. 2006 Mar 15;176(6):3585-92
references: 16517727
references: FASEB J. 2014 Aug;28(8):3703-19
references: 24812088
references: Placenta. 2010 Nov;31(11):976-81
references: 20880585
references: Curr Opin Cell Biol. 2014 Aug;29:116-25
references: 24959705
references: N Engl J Med. 2004 Feb 12;350(7):672-83
references: 14764923
references: Int J Gynaecol Obstet. 2012 Dec;119(3):234-8
references: 22986096
references: Biol Reprod. 2009 Oct;81(4):717-29
references: 19494253
references: Placenta. 2012 Dec;33(12):982-90
references: 23107341
references: Mol Hum Reprod. 2004 Jan;10(1):55-63
references: 14665707
references: Br J Obstet Gynaecol. 1997 Feb;104(2):235-40
references: 9070146
references: BJOG. 2006 Nov;113(11):1270-9
references: 17059391
references: J Obstet Gynaecol Br Commonw. 1961 Aug;68:611-7
references: 13685013
references: J Hypertens. 2013 Sep;31(9):1828-36
references: 23822977
references: PLoS One. 2013 Jul 08;8(7):e68451
references: 23861904
references: Am J Obstet Gynecol. 2012 Oct;207 (4):337.e1-8
references: 23021701
references: Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12048-53
references: 23818581
references: J Pathol Bacteriol. 1967 Apr;93(2):569-79
references: 6054057
references: Placenta. 2014 Feb;35 Suppl:S74-80
references: 24239157
references: Semin Thromb Hemost. 2005 Jun;31(3):314-20
references: 16052403
references: Cell Immunol. 1991 Nov;138(1):165-74
references: 1913835
references: J Reprod Immunol. 2006 Dec;72(1-2):33-45
references: 16843534
references: Immunology. 2012 Jun;136(2):184-91
references: 22348442
references: Placenta. 2007 Jan;28(1):1-5
references: 16620961
references: J Immunol. 2006 Feb 1;176(3):1534-42
references: 16424182
references: Int J Biochem Cell Biol. 2012 Sep;44(9):1574-84
references: 22728313
references: Placenta. 2013 May;34(5):436-42
references: 23465879
references: Hypertension. 2013 Sep;62(3):608-13
references: 23817495
references: Biol Reprod. 2012 Apr 05;86(4):103
references: 22205696
references: Placenta. 2006 Jan;27(1):56-61
references: 16310038
references: Br J Obstet Gynaecol. 1993 Oct;100(10):943-9
references: 8217980
references: Prenat Diagn. 1993 May;13(5):335-40
references: 8341630
references: Lancet. 1984 Oct 13;2(8407):841-3
references: 6148574
references: J Immunol. 2009 Jul 1;183(1):340-51
references: 19542445
references: Placenta. 2014 Apr;35(4):229-40
references: 24529666
references: J Reprod Immunol. 2012 Jun;94(2):131-41
references: 22542910
references: Am J Reprod Immunol. 2006 Nov-Dec;56(5-6):345-55
references: 17076679
references: Am J Reprod Immunol. 2011 Oct;66(4):259-69
references: 21410811
references: J Reprod Immunol. 1991 Jul;20(2):183-7
references: 1753387
references: Placenta. 2005 Jan;26(1):59-66
references: 15664412
references: Clin Chem. 2004 Nov;50(11):2187-90
references: 15502097