title: Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan.
abstract: Lipoarabinomannan is a major immunomodulatory lipoglycan found in the cell envelope of Mycobacterium tuberculosis and related human pathogens. It reproduces several salient properties of M. tuberculosis in phagocytic cells, including inhibition of pro-inflammatory cytokine production, inhibition of phagolysosome biogenesis, and inhibition of apoptosis as well as autophagy. In this review, we present our current knowledge on lipoarabinomannan structure and ability to manipulate the endocytic pathway as well as phagocyte functions. A special focus is put on the molecular mechanisms employed and the signaling pathways hijacked. Available information is discussed in the context of M. tuberculosis pathogenesis.
authors: Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Toulouse, France ; Institut de Pharmacologie et de Biologie Structurale, Université Toulouse III - Paul Sabatier Toulouse, France.
authors: Isabelle
authors: I
authors: Vergne
authors: Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Toulouse, France ; Institut de Pharmacologie et de Biologie Structurale, Université Toulouse III - Paul Sabatier Toulouse, France.
authors: Martine
authors: M
authors: Gilleron
authors: Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Toulouse, France ; Institut de Pharmacologie et de Biologie Structurale, Université Toulouse III - Paul Sabatier Toulouse, France.
authors: Jérôme
authors: J
authors: Nigou
mesh_terms: D000818:Animals; D004705:Endocytosis; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism*; D010586:Phagocytes / Q000276:immunology*; D010587:Phagocytosis; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*
chemical_list: D008070:Lipopolysaccharides; C050016:lipoarabinomannan
keywords: Mycobacterium; apoptosis; autophagy; cytokine; lipoarabinomannan; phagosome
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