title: Short- and long-term outcomes of children with cyclic vomiting syndrome.
abstract: OBJECTIVE
  To determine the efficacy of prophylactic pharmacotherapy on the short- and long-term outcomes of children with cyclic vomiting syndrome (CVS).
  
  
  METHODS
  Medical records were reviewed in 32 children who were diagnosed with CVS between 2000 and 2013. Efficacy ofprophylactic medications was classified as good vs. no response after treatment for three to six months. Long-term outcome was evaluated inpatients who had been diagnosedfor > or =2 years and classiied as 1) excellent: no episode, 2) good: one to two episodes, and 3) poor: three episodes or more during the past year.
  
  
  RESULTS
  At three to six months after treatment, good response to amitriptyline was significantly higher than propranolol (73% vs. 36%, p = 0.04). Of the 24 CVS patients whohad been diagnosed > or =2 years, data was available in 19 patients (mean age, 11.3 +/- 4.9; and mean duration from diagnosis to follow-up, 6.3+3.3 years). Excellent outcome was achieved in seven, good in seven, and poor in five children. Overall, the favorable long-term outcome (good and excellent) was 74%. Most children (86%) who hadfavorable long-term outcome had good response to the prophylactic medications in the early period of treatment.
  
  
  CONCLUSIONS
  Amitriptyline may be more effective than propranololforprophylaxis of CVS. However, a randomized controlled trial is required to confirm this result. Children with CVS have a relatively favorable long-term outcome, particularly those who initially responded well to the prophylactic medications.
authors: Suporn
authors: S
authors: Treepongkaruna
authors: Chaowapong
authors: C
authors: Jarasvaraparn
authors: Pornthep
authors: P
authors: Tanpowpong
authors: Chatmanee
authors: C
authors: Lertudomphonwanit
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000639:Amitriptyline / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D011433:Propranolol