title: Black soybean extract improves lipid profiles in fenofibrate-treated type 2 diabetics with postprandial hyperlipidemia.
abstract: Black soybeans (Glycine max (L.) Merr.) are known to be rich in polyphenols, including anthocyanins, and they have been consumed since ancient times for their beneficial effects on health. In addition, it has been reported that black soybean (BS) seed coat may ameliorate obesity and insulin resistance. In the present study, we administered BS extract to type 2 diabetics for 2 months to investigate the effects of BS on glycemic control and lipid metabolism parameters. In addition, we administered BS and antihyperlipidemic agent, fenofibrate, to patients with type 2 diabetes complicated by postprandial hyperlipidemia for 2 months and assessed the combined effects of fenofibrate and BS on serum lipid profile. The results showed that administration of the BS alone had no effect on the blood glucose or lipid levels, but that administration of fenofibrate alone and fenofibrate in combination with the BS significantly lowered their serum triglyceride (TG) level at fasting state, and the percent decrease in the serum TG level after combined administration was significantly higher than in the subjects who received fenofibrate alone. Furthermore, the serum LDL cholesterol concentration, which did not decrease when fenofibrate was administered alone, decreased significantly when the BS and fenofibrate were administered in combination. These results suggest that combined administration of the BS with fenofibrate enhanced the antihyperlipidemic action of fenofibrate, and the results of this study demonstrated the usefulness of the BS in clinical practice.
authors: 1Department of Internal Medicine, Medical Clinic, Aichi Medical University, Nagoya, Japan.
authors: Masataka
authors: M
authors: Kusunoki
authors: 2Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.
authors: Daisuke
authors: D
authors: Sato
authors: 3Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
authors: Kazuhiko
authors: K
authors: Tsutsumi
authors: 4Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
authors: Hideyo
authors: H
authors: Tsutsui
authors: 2Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.
authors: Takao
authors: T
authors: Nakamura
authors: 5Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
authors: Yoshiharu
authors: Y
authors: Oshida
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004357:Drug Synergism; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use; D019518:Postprandial Period; D012639:Seeds; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides; D011345:Fenofibrate
keywords: black soybean extract; cholesterol; fenofibrate; hyperlipidemia; triglyceride