title: High-resolution HLA-A, HLA-B, and HLA-DRB1 haplotype frequencies from the French Bone Marrow Donor Registry.
abstract: We have estimated human leukocyte antigen (HLA) haplotype frequencies using the maximum likelihood mode, which accommodates typing ambiguities. The results of the frequency distribution of the 7015 haplotypes obtained are presented here. These include a total of 114 HLA-A, 185 HLA-B, and 76 HLA-DRB1 unique alleles at each locus. Across all populations, although the most common individual HLA alleles were HLA-A(∗)02:01 (29.0%), HLA-B(∗)07:02 (11.4%), and HLA-DRB1(∗)07:01 (15.9%), the most frequent haplotype was found to be HLA-A(∗)01:01∼B(∗)08:01∼DRB1(∗)03:01.
authors: Dept. of Neurology, School of Medicine, University of California, San Francisco at San Francisco, CA, USA; Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France. Electronic address: pierreantoine.gourraud@ucsf.edu.
authors: Pierre-Antoine
authors: PA
authors: Gourraud
authors: Children's Hospital Research Institute, Oakland, CA, USA.
authors: Derek James
authors: DJ
authors: Pappas
authors: Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France.
authors: Amar
authors: A
authors: Baouz
authors: Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France.
authors: Marie-Lorraine
authors: ML
authors: Balère
authors: Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France.
authors: Federico
authors: F
authors: Garnier
authors: Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France.
authors: Evelyne
authors: E
authors: Marry
mesh_terms: D001853:Bone Marrow / Q000378:metabolism; D005602:France; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D012042:Registries; D014019:Tissue Donors
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059811:HLA-DRB1 Chains
keywords: Bone marrow donor registry; Genetic epidemiology; Haplotype; Hematopoietic stem cell donor; Peripheral blood stem cell donor cord blood bank