title: Association between Venous Angioarchitectural Features of Sporadic Brain Arteriovenous Malformations and Intracranial Hemorrhage.
abstract: OBJECTIVE
  Intracranial hemorrhage is the most serious outcome for brain arteriovenous malformations. This study examines associations between venous characteristics of these lesions and intracranial hemorrhage.
  
  
  METHODS
  Statistical analysis was performed on a prospectively maintained data base of brain AVMs evaluated at an academic medical center. DSA, CT, and MR imaging studies were evaluated to classify lesion side, drainage pattern, venous stenosis, number of draining veins, venous ectasia, and venous reflux. Logistic regression analyses were performed to identify the association of these angiographic features with intracranial hemorrhage of any age at initial presentation.
  
  
  RESULTS
  Exclusively deep drainage (OR, 3.42; 95% CI, 1.87-6.26; P < .001) and a single draining vein (OR, 1.98; 95% CI, 1.26-3.08; P = .002) were associated with hemorrhage, whereas venous ectasia (OR, 0.52; 95% CI, 0.34-0.78; P = .002) was inversely associated with hemorrhage.
  
  
  CONCLUSIONS
  Analysis of venous characteristics of brain AVMs may help determine their prognosis and thereby identify lesions most appropriate for treatment.
authors: From the Department of Radiology (M.D.A.), University of Washington, Seattle, Washington.
authors: M D
authors: MD
authors: Alexander
authors: Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.).
authors: D L
authors: DL
authors: Cooke
authors: Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (J.N., D.E.G., H.K.).
authors: J
authors: J
authors: Nelson
authors: Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (J.N., D.E.G., H.K.).
authors: D E
authors: DE
authors: Guo
authors: Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.).
authors: C F
authors: CF
authors: Dowd
authors: Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.).
authors: R T
authors: RT
authors: Higashida
authors: Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.).
authors: V V
authors: VV
authors: Halbach
authors: Department of Neurological Surgery (M.T.L.), University of California, San Francisco, San Francisco, California.
authors: M T
authors: MT
authors: Lawton
authors: Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (J.N., D.E.G., H.K.).
authors: H
authors: H
authors: Kim
authors: Department of Radiology and Biomedical Imaging (D.L.C., C.F.D., R.T.H., V.V.H., S.W.H.) steven.hetts@ucsf.edu.
authors: S W
authors: SW
authors: Hetts
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D011379:Prognosis; D014680:Veins / Q000473:pathology
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