title: Cell biology: cohesin rings leave loose ends.
abstract: Cohesins function in almost all aspects of chromosome biology. Two new studies confirm that a subset of cohesin subunits form a flexible but compressed ring that can be opened through degradation. X-ray crystallography supports potentially differing regulation of subunit associations.
authors: Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA. Electronic address: rvs3@lehigh.edu.
authors: Robert V
authors: RV
authors: Skibbens
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry* / Q000378:metabolism*; D020090:Chromosome Segregation; D004247:DNA / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry*
chemical_list: D018797:Cell Cycle Proteins; D011508:Chondroitin Sulfate Proteoglycans; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D004247:DNA
references: J Cell Biol. 1998 Sep 21;142(6):1595-604
references: 9744887
references: EMBO J. 2003 Jun 2;22(11):2764-75
references: 12773391
references: Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):537-42
references: 15897179
references: Cell. 2003 Mar 21;112(6):765-77
references: 12654244
references: Mol Cell. 2002 Apr;9(4):773-88
references: 11983169
references: J Cell Biol. 2002 Feb 4;156(3):419-24
references: 11815634
references: Genome Res. 2000 Nov;10(11):1664-71
references: 11076851
references: Science. 2014 Nov 21;346(6212):968-72
references: 25414306
references: Science. 2014 Nov 21;346(6212):963-7
references: 25414305
references: PLoS One. 2014;9(6):e100470
references: 24963665
references: PLoS Genet. 2013;9(12):e1004036
references: 24367282
references: Development. 2013 Sep;140(18):3715-8
references: 23981654
references: PLoS One. 2013;8(7):e69458
references: 23874961
references: Cell. 2012 Aug 31;150(5):961-74
references: 22901742
references: PLoS Genet. 2012;8(8):e1002856
references: 22912589
references: Nucleic Acids Res. 2012 Jan;40(2):914-27
references: 21937514
references: Trends Genet. 2011 Dec;27(12):499-506
references: 21943501
references: Nat Struct Mol Biol. 2011 Aug;18(8):894-901
references: 21765419
references: J Biol Chem. 2009 Mar 27;284(13):8507-15
references: 19141609
references: EMBO J. 2007 Aug 22;26(16):3783-93
references: 17660750