title: Treatment of thromboangiitis obliterans (Buerger's disease) with high-potency vasodilators.
abstract: Thromboangiitis obliterans (TAO) or Buerger's disease is a vascular inflammatory thrombotic occlusive and segmental disease affecting distal small and medium-sized arteries of the limbs. Tobacco is the main trigger factor and avoiding it is the main treatment. Frequently, it is necessary to use high-potency vasodilators, such as iloprost, bosentan, sildenafil, or alprostadil, to relieve symptoms and reduce the risk of amputation. Iloprost is the only one that has been shown to be effective in randomized clinical trials. We report the third case of TAO treated with sildenafil and a new case treated with bosentan. This condition can be diagnosed and treated by a dermatologist. We would like to highlight the excellent clinical response despite the fact that patients continued to smoke. This finding may have important therapeutic implications because early treatment may prevent amputation and can be effective even during the process of giving up smoking.
authors: Department of Dermatology, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: David
authors: D
authors: Jiménez-Gallo
authors: Department of Dermatology, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: Cristina
authors: C
authors: Albarrán-Planelles
authors: Department of Dermatology, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: Cintia
authors: C
authors: Arjona-Aguilera
authors: Department of Pharmacy, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: German
authors: G
authors: Blanco-Sánchez
authors: Department of Pharmacy, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: María Eugenia
authors: ME
authors: Rodríguez-Mateos
authors: Department of Dermatology, Hospital Universitario Puerta del Mar, Cadiz, Spain.
authors: Mario
authors: M
authors: Linares-Barrios
mesh_terms: D000328:Adult; D000077300:Bosentan; D006225:Hand / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D000068677:Sildenafil Citrate / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D013919:Thromboangiitis Obliterans / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D013449:Sulfonamides; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D000077300:Bosentan
keywords: Buerger's disease; bosentan; sildenafil; thromboangiitis obliterans