title: Early blood plutonium retention in nonhuman primates compared to the NCRP 156 wound biokinetic model.
abstract: Data from animal experiments are relied upon for understanding the biokinetics of contaminant retention and excretion where insufficient human data exist. Records involving nonhuman primate experiments performed from 1973 to 1987 were collected and compiled by researchers at the Lawrence Berkeley Laboratory. These records included early blood samples that were taken after soluble plutonium was administered via intramuscular, subcutaneous, or intravenous injection. Samples were collected as early as 5 min post injection with several samples collected during the first few weeks. The NCRP 156 biokinetic model was developed primarily from animal experiments due to insufficient human data not influenced by chelation therapy. This work compared the NCRP 156 biokinetic model default transfer rate constants to the early blood excretion data from nonhuman primate experiments for 238Pu. These results indicated that the blood content of nonhuman primates exhibited "moderate" retention properties for simulated wound conditions. Additionally, there was no evidence of long-term retention of plutonium in the whole blood samples, confirming that plutonium was not incorporated within blood cells. Particle solubility characteristics should be considered for wounds when using the NCRP 156 wound biokinetic model.
authors: *Department of Nuclear Engineering and Health Physics, Idaho State University, 921 South 8th Avenue, Stop 8060, Pocatello, ID 83209-8060; †Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, Albuquerque, NM 87108.
authors: Kevin
authors: K
authors: Konzen
authors: Richard
authors: R
authors: Brey
authors: Raymond
authors: R
authors: Guilmette
mesh_terms: D000818:Animals; D005260:Female; D007700:Kinetics; D008251:Macaca; D008297:Male; D008954:Models, Biological; D011005:Plutonium / Q000097:blood* / Q000493:pharmacokinetics; D011835:Radiation Protection; D014947:Wounds and Injuries / Q000378:metabolism*
chemical_list: D011005:Plutonium