title: [Multicentric Castleman disease not associated with HHV-8 and HIV viruses].
abstract: Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case.
authors: Serviço de Reumatologia do Hospital Heliópolis, São Paulo, SP, Brasil.
authors: Denise de Fatima
authors: Dde F
authors: Forteski
authors: Serviço de Reumatologia do Hospital Heliópolis, São Paulo, SP, Brasil.
authors: Fernanda Calil Machado
authors: FC
authors: Netto
authors: Serviço de Reumatologia do Hospital Heliópolis, São Paulo, SP, Brasil.
authors: Andrea Barranjard Vannucci
authors: AB
authors: Lomonte
authors: Serviço de Reumatologia do Hospital Heliópolis, São Paulo, SP, Brasil.
authors: Bruno César Cavalcanti
authors: BC
authors: dos Anjos
authors: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors: Maria Claudia Nogueira
authors: MC
authors: Zerbini
authors: Serviço de Reumatologia do Hospital Heliópolis, São Paulo, SP, Brasil. Electronic address: criszerb@uol.com.br.
authors: Cristiano Augusto de Freitas
authors: CA
authors: Zerbini
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000175:diagnosis*; D005260:Female; D015497:HIV-1; D019288:Herpesvirus 8, Human; D006801:Humans
keywords: Anaemia; Anemia; Autoimmune; Autoimune; B lymphocytes; Castleman's disease; Doença de Castleman; Inflamação; Inflammation; Interleucina‐6; Interleukyn‐6; Linfócitos B