title: 18F-FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas: correlation with histopathology.
abstract: This study aimed to correlate (18)F-FB-mini-PEG-E[c(RGDyK)](2) ((18)F-FPRGD2) uptake to integrin αvβ3 expression and angiogenesis in renal tumors.
  
  
  METHODS
  (18)F-FPRGD2 PET/CT was performed on 27 patients before surgical resection (median 4 d) of a renal mass. The (18)F-FPRGD2 uptake was compared with integrin αvβ3, CD31, CD105, and Ki-67 using immunohistochemistry; with placental growth factor and vascular endothelial growth factor receptors 1 and 2 using reverse transcription polymerase chain reaction; and with vascular endothelial growth factor A isoforms using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Overall, (18)F-FPRGD2 uptake significantly correlated (P < 0.0001) with integrin αvβ3 expression in renal masses. However, it correlated only with integrin αvβ3-positive vessels in the group of papillary carcinomas whereas it correlated with integrin αvβ3 expression by tumor cells in the clear cell carcinoma group.
  
  
  CONCLUSIONS
  (18)F-FPRGD2 uptake reflects the expression of integrin αvβ3 in renal tumors but represents angiogenesis only when tumor cells do not express the integrin.
authors: Nuclear Medicine and Oncological Imaging Division, Medical Physics Department, CHU Liege, Liege, Belgium nwithofs@chu.ulg.ac.be.
authors: Nadia
authors: N
authors: Withofs
authors: Laboratory of Tumor and Developmental Biology, GIGA Research, University of Liege, Liege, Belgium.
authors: Nicolas
authors: N
authors: Signolle
authors: Pathology Department, CHU Liege, Liege, Belgium.
authors: Joan
authors: J
authors: Somja
authors: Nuclear Medicine and Oncological Imaging Division, Medical Physics Department, CHU Liege, Liege, Belgium.
authors: Pierre
authors: P
authors: Lovinfosse
authors: Pathology Department, CHU Liege, Liege, Belgium.
authors: Eugène Mutijima
authors: EM
authors: Nzaramba
authors: Cyclotron Research Center, University of Liege, Liege, Belgium.
authors: Frédéric
authors: F
authors: Mievis
authors: Cyclotron Research Center, University of Liege, Liege, Belgium.
authors: Fabrice
authors: F
authors: Giacomelli
authors: Urology Department, CHU Liege, Liege, Belgium; and.
authors: David
authors: D
authors: Waltregny
authors: Laboratory of Tumor and Developmental Biology, GIGA Research, University of Liege, Liege, Belgium.
authors: Didier
authors: D
authors: Cataldo
authors: Molecular Imaging Program at Stanford (MIPS), Radiology Department, Stanford University, Stanford, California.
authors: Sanjiv S
authors: SS
authors: Gambhir
authors: Nuclear Medicine and Oncological Imaging Division, Medical Physics Department, CHU Liege, Liege, Belgium.
authors: Roland
authors: R
authors: Hustinx
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D009683:Nuclear Medicine; D010456:Peptides, Cyclic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C515149:4-fluorobenozyl-glutamyl-cyclo(arginyl-glycyl-aspartyl-tyrosyl-lysyl)2; D039302:Integrin alphaVbeta3; D010456:Peptides, Cyclic; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019275:Radiopharmaceuticals; D011092:Polyethylene Glycols
keywords: PET; RGD; angiogenesis; integrin; renal cancer