title: Recurrent stent thrombosis in a patient with antiphospholipid syndrome and dual anti-platelet therapy non-responsiveness.
abstract: Antiphospholipid syndrome (APS), the most common acquired hypercoagulable condition, is diagnosed by persistent presence of antiphospholipid antibodies and episodes of vascular thrombosis. It may be an important predisposing factor for stent thrombosis, resulting in poor outcomes. Also, anti-platelet therapy non-responsiveness is associated with stent thrombosis. We report a case of a 39-year-old man who after undergoing successful percutaneous coronary intervention for significant coronary artery disease suffered repeated stent thrombosis events leading to ST-segment elevation myocardial infarction. Eventually, he underwent coronary artery bypass surgery because of uncontrolled thrombosis and was diagnosed as having APS and dual antiplatelet therapy non-responsiveness.
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: You-Hong
authors: YH
authors: Lee
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Hyoung-Mo
authors: HM
authors: Yang
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Seung-Jea
authors: SJ
authors: Tahk
authors: Department of Thoracic and Cadiovascular Surgery, Ajou University School of Medicine, Suwon, Korea.
authors: You-Sun
authors: YS
authors: Hong
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Jin-Sun
authors: JS
authors: Park
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Kyoung-Woo
authors: KW
authors: Seo
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Yong-Woo
authors: YW
authors: Choi
authors: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors: Choong-Kyun
authors: CK
authors: Noh
keywords: Antiphospholipid syndrome; Percutaneous coronary intervention; Stents; Thrombosis
references: JAMA. 2006 Mar 1;295(9):1050-7
references: 16507806
references: Blood Coagul Fibrinolysis. 2004 Jan;15(1):95-8
references: 15166950
references: JAMA. 2004 Feb 4;291(5):576-84
references: 14762036
references: Cardiology. 2012;122(2):76-82
references: 22722386
references: JACC Cardiovasc Interv. 2011 Aug;4(8):896-904
references: 21851905
references: Heart. 1998 Jan;79(1):96-8
references: 9505929
references: Int J Cardiovasc Intervent. 2003;5(1):44-6
references: 12623565
references: Rev Cardiovasc Med. 2006 Fall;7(4):244-6
references: 17224868
references: Circulation. 2009 Feb 24;119(7):987-95
references: 19204304
references: Eur Heart J. 2008 Dec;29(24):3011-21
references: 18987096
references: Br J Haematol. 2001 Dec;115(3):672-8
references: 11736953
references: Case Rep Med. 2010;2010:974149
references: 20592997
references: J Thromb Haemost. 2006 Feb;4(2):295-306
references: 16420554
references: Autoimmunity. 1998;27(3):141-8
references: 9609131
references: Lupus. 2003;12(7):518-23
references: 12892391
references: Arthritis Rheum. 2002 Apr;46(4):1019-27
references: 11953980
references: J Am Coll Cardiol. 2009 Apr 21;53(16):1399-409
references: 19371823
references: Arthritis Rheum. 1999 Jul;42(7):1309-11
references: 10403256