title: Treatment of spontaneous intracranial hypotension with intravenous Factor XIII administration: initial clinical experience.
abstract: OBJECTIVE
  Coagulation Factor XIII plays an important role in wound healing by stabilizing the fibrin clot. We hypothesized that Factor XIII administration might promote the repair of cerebrospinal fluid leak sites and lead to resolution of the orthostatic headache in patients with spontaneous intracranial hypotension (SIH). The aim of this study was to investigate the efficacy of intravenous Factor XIII administration in SIH patients.
  
  
  METHODS
  A retrospective review of nine patients (four men, five women; mean age 42.3 yr) with SIH resistant to conservative treatment (bed rest, hydration and analgesics) was performed. All patients had an orthostatic headache. Intravenous administration of Factor XIII (1200 units per day for at least five days) was additionally performed on all patients.
  
  
  RESULTS
  The orthostatic headache completely resolved and never reoccurred in six patients (67%), and partially resolved in two patients (22%). One patient (11%) had no change in headache activity. No complications occurred in any patients treated with Factor XIII.
  
  
  CONCLUSIONS
  This study may suggest that intravenous administration of Factor XIII is useful for treating SIH, even if the patients are resistant to conservative treatment.
authors: National Defense Medical College, Department of Neurosurgery, Tokorozawa, Japan.
authors: Kimihiro
authors: K
authors: Nagatani
authors: Satoru
authors: S
authors: Takeuchi
authors: Kojiro
authors: K
authors: Wada
authors: Kentaro
authors: K
authors: Mori
authors: Katsuji
authors: K
authors: Shima
mesh_terms: D000328:Adult; D000368:Aged; D065634:Cerebrospinal Fluid Leak / Q000517:prevention & control; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D019585:Intracranial Hypotension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005176:Factor XIII