title: From the camp pathway to search the ketamine-related learning and memory.
abstract: Protein kinase A (PKA) phosphorylates and activates cAMP response element-binding protein (CREB), which then binds to CRE domain on DNA and in turn activates genes involved in the process of learning and memorization. It has been demonstrated that CREB is involve in the learning and memory deficits that are caused by ketamine. In this review, we attempt to discuss the role of ketamine and cAMP pathway and relevant regulatory protein ERK in learning and memory through the molecular mechanism and signaling pathways. In this review, we also try to find a new way to treat the impairment in learning and memory induced by ketamine.
authors: Department of Anesthesiology, Affiliated Tongji Hospital of Tongji University, Putuo, Shanghai, China. pengshengtongji@gmail.com.
authors: S
authors: S
authors: Peng
authors: X
authors: X
authors: Yang
authors: G-J
authors: GJ
authors: Liu
authors: X-Q
authors: XQ
authors: Zhang
authors: G-L
authors: GL
authors: Wang
authors: H-Y
authors: HY
authors: Sun
mesh_terms: D000778:Anesthetics, Dissociative / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D007649:Ketamine / Q000494:pharmacology* / Q000633:toxicity; D007858:Learning / Q000187:drug effects*; D020935:MAP Kinase Signaling System; D008568:Memory / Q000187:drug effects*; D015398:Signal Transduction
chemical_list: D000778:Anesthetics, Dissociative; D017362:Cyclic AMP Response Element-Binding Protein; D007649:Ketamine; D017868:Cyclic AMP-Dependent Protein Kinases