title: Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy.
abstract: OBJECTIVE
  We present a single-center prospective study, validating the use of 3D multimodality imaging (3 DMMI) in patients undergoing intracranial electroencephalography (IC-EEG).
  
  
  METHODS
  IC-EEG implantation preparation entails first designing of the overall strategy of implantation (strategy) and second the precise details of implantation (planning). For each case, the multidisciplinary team made decisions on strategy and planning before the disclosure of multimodal brain imaging models. Any changes to decisions, following disclosure of the multimodal models, were recorded.
  
  
  RESULTS
  Disclosure of 3 DMMI led to a change in strategy in 15 (34%) of 44 individuals. The changes included addition and subtraction of electrodes, addition of grids, and going directly to resection. For the detailed surgical planning, 3 DMMI led to a change in 35 (81%) of 43 individuals. Twenty-five (100%) of 25 patients undergoing stereo-EEG (SEEG) underwent a change in electrode placement, with 158 (75%) of 212 electrode trajectories being altered.
  
  
  CONCLUSIONS
  The use of 3 DMMI makes substantial changes in clinical decision making.
authors: Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom; Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom; MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom.
authors: Mark
authors: M
authors: Nowell
authors: Roman
authors: R
authors: Rodionov
authors: Gergely
authors: G
authors: Zombori
authors: Rachel
authors: R
authors: Sparks
authors: Gavin
authors: G
authors: Winston
authors: Jane
authors: J
authors: Kinghorn
authors: Beate
authors: B
authors: Diehl
authors: Tim
authors: T
authors: Wehner
authors: Anna
authors: A
authors: Miserocchi
authors: Andrew W
authors: AW
authors: McEvoy
authors: Sebastien
authors: S
authors: Ourselin
authors: John
authors: J
authors: Duncan
mesh_terms: D000293:Adolescent; D000328:Adult; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Epilepsy surgery; Image integration; Presurgical evaluation
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