title: Intramolecular heterocyclization of O-propargylated aromatic hydroxyaldehydes as an expedient route to substituted chromenopyridines under metal-free conditions.
abstract: A concise and regioselective approach to the synthesis of chromenopyridine and chromenopyridinone derivatives was developed. The synthetic strategy relies on the O-propargylation of aromatic hydroxyaldehydes followed by reaction with propargylamine. The intramolecular cycloaddition reaction between the alkyne and azadiene, which is formed as an intermediate, furnished the desired skeletons.
authors: Department of Chemistry, Middle East Technical University , 06800 Ankara, Turkey.
authors: Selbi
authors: S
authors: Keskin
authors: Metin
authors: M
authors: Balci