title: Salivary gland dysfunction after radioactive iodine (I-131) therapy in patients following total thyroidectomy: emphasis on radioactive iodine therapy dose.
abstract: OBJECTIVE
  The purpose of this study was to retrospectively evaluate symptoms, images of salivary gland dysfunction, and related clinical factors in thyroid cancer patients with total thyroidectomy followed by radioiodine therapy (RIT).
  
  
  METHODS
  We included 164 patients who underwent thyroid ultrasonography or contrast-enhanced neck computed tomography more than 6 months later after RIT. Correlation between subjective symptoms and various RIT doses was also evaluated.
  
  
  RESULTS
  Swelling and decreased salivary volume were the most common symptoms and images. RIT dose was the only factor with a positive correlation (P<.001).
  
  
  CONCLUSIONS
  The dose of RIT should be carefully determined to minimize gland dysfunction.
authors: Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Han Na
authors: HN
authors: Lee
authors: Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Ji Young
authors: JY
authors: An
authors: Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Kyung Mi
authors: KM
authors: Lee
authors: Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea. Electronic address: euijkim@hanmail.net.
authors: Eui Jong
authors: EJ
authors: Kim
authors: Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Woo Suk
authors: WS
authors: Choi
authors: Department of Nuclear Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Deog Yoon
authors: DY
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012466:Salivary Gland Diseases / Q000175:diagnosis* / Q000209:etiology*; D012469:Salivary Glands / Q000000981:diagnostic imaging; D012796:Sialography; D013964:Thyroid Neoplasms / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes
keywords: Radiation sialadenitis; Radioiodine therapy; Salivary gland dysfunction; Total thyroidectomy