title: Effectiveness of renal denervation for treatment of resistant hypertension: an evidence-based case report.
abstract: OBJECTIVE
  To determine whether the renal sympathetic--nerve ablation method is more effective compared to multiple anti--hypertensive drug among patients with resistant hypertension.
  
  
  METHODS
  a search was conducted on PubMed. The selection of title and abstract was conducted using inclusion and exclusion criteria, which led to five relevant articles. The selected studies were critically appraised for its validity, importance and applicability.
  
  
  RESULTS
  one of studies showed that renal denervation is not effectively reduced blood pressure in patients with resistant hypertension; nevertheless other studies showed significant results.
  
  
  CONCLUSIONS
  literature with strongest evidence showed that there is no relationship between renal sympathetic-nerve ablation procedure and reduction of blood pressure. However, as there is still some methodological flaw on the literature, we recommend doing another study that may find the appropriate results.
authors: Department of Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
authors: Minarma
authors: M
authors: Siagian
authors: Aldo
authors: A
authors: Ferly
authors: Arinna
authors: A
authors: Irianti
authors: Arky
authors: A
authors: Kurniati
authors: Florence
authors: F
authors: Low
authors: Ras A
authors: RA
authors: Riza
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D004351:Drug Resistance; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D013562:Sympathectomy
chemical_list: D000959:Antihypertensive Agents