title: Cu-catalyzed concise synthesis of pyridines and 2-(1H)-pyridones from acetaldehydes and simple nitrogen donors.
abstract: A highly selective copper-catalyzed concise synthesis of 3,5-diarylpyridine and 2-(1H)-pyridone has been achieved through cascade Chichibabin-type cyclization, C(sp(3))-C(sp(3)) cleavage, and aerobic oxidation. Azide, ceric ammonium nitrate (CAN), and 2-aminopyridine are disclosed as efficient nitrogen donors in this Cu-catalysis using O2 as the oxidant. Water and molecular oxygen were employed as the oxygen source in the case of oxygenation.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Xue Yuan Road 38, Beijing 100191, China.
authors: Ziyuan
authors: Z
authors: Li
authors: Xiaoqiang
authors: X
authors: Huang
authors: Feng
authors: F
authors: Chen
authors: Chun
authors: C
authors: Zhang
authors: Xiaoyang
authors: X
authors: Wang
authors: Ning
authors: N
authors: Jiao
mesh_terms: D000079:Acetaldehyde / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000631:Aminopyridines; D011725:Pyridines; D011728:Pyridones; D003300:Copper; D000079:Acetaldehyde; D009584:Nitrogen; D010100:Oxygen; C032439:alpha-aminopyridine