title: Rotationally resliced 3D prostate TRUS segmentation using convex optimization with shape priors.
abstract: OBJECTIVE
  Efficient and accurate segmentations of 3D end-firing transrectal ultrasound (TRUS) images play an important role in planning of 3D TRUS guided prostate biopsy. However, poor image quality of the input 3D TRUS images, such as strong imaging artifacts and speckles, often makes it a challenging task to extract the prostate boundaries accurately and efficiently.
  
  
  METHODS
  In this paper, the authors propose a novel convex optimization-based approach to delineate the prostate surface from a given 3D TRUS image, which reduces the original 3D segmentation problem to a sequence of simple 2D segmentation subproblems over the rotational reslices of the 3D TRUS volume. Essentially, the authors introduce a novel convex relaxation-based contour evolution approach to each 2D slicewise image segmentation with the joint optimization of shape information, where the learned 2D nonlinear statistical shape prior is incorporated to segment the initial slice, its result is propagated as a shape constraint to the segmentation of the following slices. In practice, the proposed segmentation algorithm is implemented on a GPU to achieve the high computational performance.
  
  
  RESULTS
  Experimental results using 30 patient 3D TRUS images show that the proposed method can achieve a mean Dice similarity coefficient of 93.4% ± 2.2% in 20 s for one 3D image, outperforming the existing local-optimization-based methods, e.g., level-set and active-contour, in terms of accuracy and efficiency. In addition, inter- and intraobserver variability experiments show its good reproducibility.
  
  
  CONCLUSIONS
  A semiautomatic segmentation approach is proposed and evaluated to extract the prostate boundary from 3D TRUS images acquired by a 3D end-firing TRUS guided prostate biopsy system. Experimental results suggest that it may be suitable for the clinical use involving the image guided prostate biopsy procedures.
authors: Imaging Research Laboratories, Robarts Research Institute, The University of Western Ontario, London, Ontario N64 5K8, Canada.
authors: Wu
authors: W
authors: Qiu
authors: Imaging Research Laboratories, Robarts Research Institute, The University of Western Ontario, London, Ontario N64 5K8, Canada.
authors: Jing
authors: J
authors: Yuan
authors: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205.
authors: Eranga
authors: E
authors: Ukwatta
authors: Imaging Research Laboratories, Robarts Research Institute, The Department of Medical Biophysics, The University of Western Ontario, London, Ontario N64 5K8, Canada.
authors: Aaron
authors: A
authors: Fenster
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001185:Artificial Intelligence; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D025341:Principal Component Analysis; D011467:Prostate / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D014463:Ultrasonography