title: Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus).
abstract: For over three decades, cotton rats have been a preferred model for human Respiratory Syncytial Virus (RSV) infection and pathogenesis, and a reliable model for an impressive list of human respiratory pathogens including adenoviruses, para influenza virus, measles, and human metapneumo virus. The most significant contribution of the cotton rat to biomedical research has been the development of anti-RSV antibodies for prophylactic use in high-risk infants. More recently, however, the cotton rat model has been further explored as a model for infection with other respiratory viral pathogens including influenza and rhinovirus.Together with RSV, these viruses inflict the greatest impact on the human respiratory health.This review will focus on the characteristics of these new models and their potential contribution to the development of new therapies.
authors: Sigmovir Biosystems Inc. Rockville, USA.
authors: Jorge Cg
authors: JC
authors: Blanco
authors: Sigmovir Biosystems Inc. Rockville, USA.
authors: Marina S
authors: MS
authors: Boukhvalova
authors: Department of Veterinary Medicine, University of Maryland, Collage Park, USA.
authors: Daniel R
authors: DR
authors: Perez
authors: Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, USA.
authors: Stefanie N
authors: SN
authors: Vogel
authors: Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, USA.
authors: Adriana
authors: A
authors: Kajon
keywords: Cotton rat; Influenza; Rhinovirus; Viral infections
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