title: Antienflamatuar and antiadhesive effect of clioquinol.
abstract: OBJECTIVE
  The aim of this study is to investigate the expected adhesion-modifying effect of clinoquinol which has metal-chelating feature that limits the inflammation and fibroblastic activity.
  
  
  METHODS
  A total of 40 Wistar Albino rats were included, which were divided into 5 groups. Group-1 constituted the sham group. Other groups, adhesions were induced by performing cecal abrasion on the rats. For treatment, saline solution was added to Group-2, carboxymethylcellulose was added to Group-3, methylene blue was added to Group-4, and clioquinol was added to Group-5. Blood samples were obtained from the heart to measure IL-10 and TNF α-levels. Adhesions were evaluated both macroscopically and histopathologically.
  
  
  RESULTS
  Clioquinol reduced adhesions at significant level via decreasing the inflammation and fibroblastic activity in the adhesion-induced rats. At macroscopic level, carboxymethylcellulose and clioquinol were the most potent agents in reducing adhesions. Nonetheless, significant foreign body-reaction was observed in the carboxymethylcellulose-treated group.
  
  
  CONCLUSIONS
  Clioquinol could reduce the formation of intra-abdominal adhesions. It exerts this activity by limiting the inflammation and fibroblastic activity between the intestines and serous surfaces. Furthermore, it does not induce a foreign body reaction. Due to these properties, we conclude that clioquinol can be used as an alternative agent to prevent adhesions.
authors: Sakarya University, Medical School, Department of Pediatric Surgery, Sakarya, Turkey. Electronic address: tyildiz44@gmail.com.
authors: Turan
authors: T
authors: Yildiz
authors: Sakarya University, Medical School, Department of Pediatric Surgery, Sakarya, Turkey.
authors: Zekeriya
authors: Z
authors: Ilce
authors: Sakarya University, Medical School, Department of Pathology, Sakarya, Turkey.
authors: Muzaffer
authors: M
authors: Yildirim
authors: Sakarya University, Medical School, Department of Biochemistry, Sakarya, Turkey.
authors: Mehmet
authors: M
authors: Akdogan
authors: Sakarya University, Medical School, Department of Emergency Medicine, Sakarya, Turkey.
authors: Yusuf
authors: Y
authors: Yurumez
authors: Sakarya University, Medical School, Department of Pediatric Surgery, Sakarya, Turkey.
authors: Onursal
authors: O
authors: Varlikli
authors: Sakarya University, Medical School, Department of Pathology, Sakarya, Turkey.
authors: Fatma Husniye
authors: FH
authors: Dilek
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use; D002432:Cecum / Q000473:pathology* / Q000601:surgery*; D007464:Clioquinol / Q000627:therapeutic use*; D007249:Inflammation; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D011183:Postoperative Complications; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007464:Clioquinol; D002266:Carboxymethylcellulose Sodium
keywords: Adeshesion; Clioquinol; Intestine; Rat