title: Diffuse dermal angiomatosis associated with severe atherosclerosis: two cases and review of the literature.
abstract: Diffuse dermal angiomatosis (DDA) is a rare condition characterized by endothelial proliferation in the reticular dermis. Several diseases have been associated with DDA, including peripheral arterial disease (PAD). We report two cases of DDA associated with PAD. Patient 1 was a 71-year-old woman, who presented with painful necrotic ulcerations on her trunk and a medical history of PAD. Skin biopsy revealed a dermal proliferation of endothelial cells, and despite medical treatment, she died 1 month later. Patient 2 was an 81-year-old man, who presented with an erythematous, bluish plaque of the shoulder. He was a heavy smoker, with severe PAD. Biopsy showed dermal capillary hyperplasia, with a few fibrin thrombi, and follow-up only was recommended. In both cases, laboratory tests and Doppler ultrasonography ruled out other thrombotic conditions and vascularitis. DDA is a rare complication of PAD, and the optimum medical treatment remains to be clarified, especially when revascularization has failed or is not possible, as in our cases.
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: E
authors: E
authors: Crickx
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: A
authors: A
authors: Saussine
authors: Department of Pathology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: M D
authors: MD
authors: Vignon-Pennamen
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: F
authors: F
authors: Cordoliani
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: F
authors: F
authors: Mouly
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: M
authors: M
authors: Bagot
authors: Department of Dermatology, Université Paris-Diderot, Assistance Publique-Hôpitaux de Paris, Hôpital Saint Louis, Paris, France.
authors: M
authors: M
authors: Rybojad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000798:Angiomatosis / Q000209:etiology* / Q000473:pathology; D050197:Atherosclerosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D017445:Skin Diseases, Vascular / Q000209:etiology* / Q000473:pathology