title: The role of cytology in the era of HPV-related head and neck carcinoma.
abstract: Enlarged neck lymph nodes are very often subject to fine needle aspiration biopsy to detect metastatic disease in patients with suspected or proven squamous cell carcinoma in head and neck region. Cytology specimens of metastatic carcinoma in such patients are routinely evaluated for human papilloma virus (HPV) to identify patients with HPV-related head and neck squamous cell carcinoma. Different types of cytology specimens including smears, cytospins, cell blocks and aspirated material in the rinse can all be used for different types of HPV testing such as immunohistochemistry for p16, HPV-in situ hybridization, and HPV-Polymerase chain reaction. There is currently no consensus regarding the testing of high-risk HPV in cytology specimens. The establishment of standardized HPV testing of cytology specimens is of utmost importance and is eagerly awaited.
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 053, Houston, TX 77030-4095.
authors: Sinchita
authors: S
authors: Roy-Chowdhuri
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 053, Houston, TX 77030-4095. Electronic address: skrishna@mdanderson.org.
authors: Savitri
authors: S
authors: Krishnamurthy
mesh_terms: D044963:Biopsy, Fine-Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000821:virology*; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000821:virology*; D011237:Predictive Value of Tests; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D004279:DNA, Viral
keywords: Basaloid carcinoma; Human papilloma virus; Oropharynx; Squamous carcinoma; p16