title: Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10.
abstract: Phyto-oestrogens are a family of plant-derived xeno-oestrogens that have been shown to prevent cancer in some studies. Whether phyto-oestrogen intake affects obesity status in a population is still unclear. In the present cross-sectional study, we examined the association of urinary phyto-oestrogen metabolites with obesity and metabolic parameters in children and adults. Data from 1294 children (age 6-19 years) and from 3661 adults (age ≥ 20 years) who participated in the US National Health and Nutrition Examination Survey 2001-10 were analysed. Multivariate logistic regression was applied to investigate the associations of BMI, waist circumference, serum metabolites (total cholesterol, HDL-cholesterol, LDL-cholesterol, TAG, fasting glucose and fasting insulin) and the metabolic syndrome with urinary phyto-oestrogen levels. When stratified by age and sex, we found a stronger association (OR 0·30, 95 % CI 0·17, 0·54; P< 0·001) between urinary enterolactone levels and obesity in adult males (age 20-60 years) than in children (age 12-19 years) or the elderly (age >60 years) in the same survey. However, no associations with urinary daidzein, O-desmethylangolensin, equol, enterodiol or genistein were found in the overall population. We also found that the elevation of enterolactone levels was inversely associated with TAG levels, fasting glucose levels, fasting insulin levels and the metabolic syndrome in males aged 20-60 years, but positively associated with HDL-cholesterol levels. The present results provide epidemiological evidence that urinary enterolactone is inversely associated with obesity in adult males.
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University,Nanjing211166,People's Republic of China.
authors: Cheng
authors: C
authors: Xu
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University,Nanjing211166,People's Republic of China.
authors: Qian
authors: Q
authors: Liu
authors: Department of Environmental and Occupational Health Sciences,School of Public Health and Information Health Sciences, University of Louisville,Louisville,KY40292,USA.
authors: Qunwei
authors: Q
authors: Zhang
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University,Nanjing211166,People's Republic of China.
authors: Aihua
authors: A
authors: Gu
authors: Department of Surgery,Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine,No. 197 Ruijin Er Road,Shanghai200025,People's Republic of China.
authors: Zhao-Yan
authors: ZY
authors: Jiang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000652:urine; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D017705:Lignans / Q000652:urine*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000652:urine*; D008875:Middle Aged; D009749:Nutrition Surveys; D009765:Obesity / Q000652:urine*; D048789:Phytoestrogens / Q000652:urine*; D012727:Sex Characteristics; D014481:United States; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D017705:Lignans; D048789:Phytoestrogens; D015107:4-Butyrolactone; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone
keywords: National Health and Nutrition Examination Survey