title: Spontaneous regression of infantile dural-based non-Langerhans cell histiocytosis after surgery: case report.
abstract: The authors report the case of a large left occipital mass lesion in an 8-month-old boy who presented with seizure. Neuroimaging demonstrated an approximately 5-cm extraaxial tumor, and the patient underwent partial resection. The tumor was strongly attached to the tentorium and falx. In the postoperative course the residual lesion regressed spontaneously, and after 5 years only a slight residual tumor remained along the tentorium. Histopathological examination of the tumor revealed non-Langerhans cell histiocytosis (non-LCH). However, the tumor was not diagnosed as juvenile xanthogranuloma (JXG) because it lacked Touton giant cells. Hence, the authors described this lesion as a fibroxanthogranuloma. Most intracraniospinal non-LCHs have been reported as JXG; however, several cases of xanthomatous tumors with histopathological features resembling those of JXG have been described as fibrous xanthoma, xanthoma, fibroxanthoma, and xanthogranuloma. Among JXG and the xanthomatous tumors, a review of the literature revealed several cases of dural-based tumors; these dural-based tumors have had favorable courses, including the case described in this report. In addition, the patient in the present case experienced spontaneous regression of the residual tumor. The authors report this unique case and review the literature on isolated intracraniospinal non-LCHs, especially in cases of dural-based lesion.
authors: Departments of 1 Neurosurgery and.
authors: Yohei
authors: Y
authors: Miyake
authors: Susumu
authors: S
authors: Ito
authors: Mio
authors: M
authors: Tanaka
authors: Yukichi
authors: Y
authors: Tanaka
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1 / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000473:pathology; D015620:Histiocytic Disorders, Malignant / Q000150:complications / Q000175:diagnosis* / Q000469:parasitology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D037181:Lectins, C-Type / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D037241:Mannose-Binding Lectins / Q000032:analysis; D009365:Neoplasm Regression, Spontaneous; D018365:Neoplasm, Residual / Q000175:diagnosis* / Q000473:pathology; D059906:Neuroimaging; D011956:Receptors, Cell Surface / Q000032:analysis; D012640:Seizures / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000098902:CD163 Antigen; D000097382:CD68 Molecule
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D000098902:CD163 Antigen; C419393:CD1a antigen; C121916:CD207 protein, human; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C096893:HAM-56 antibody
keywords: EMA = epithelial membrane antigen; GFAP = glial fibrillary acidic protein; JXG = juvenile xanthogranuloma; LCA = leukocyte common antigen; LCH = Langerhans cell histiocytosis; NFP = neurofilament protein; XG = xanthogranuloma; dural-based lesion; infant; non-Langerhans cell histiocytosis; oncology; spontaneous regression; α-SMA = α–smooth muscle actin