title: Characteristics of Sweet Syndrome in patients with acute myeloid leukemia.
abstract: BACKGROUND
  Sweet syndrome (SS) is associated with hematologic malignancies including acute myeloid leukemia (AML).
  
  
  METHODS
  Records of patients with AML treated at our institution were reviewed to identify those with SS. Patient characteristics, laboratory values, and cytogenetic and molecular abnormalities were retrospectively reviewed.
  
  
  RESULTS
  We identified 21 of 2178 (1%) AML patients who demonstrated clinical signs and symptoms, and histological features consistent with SS. Eleven patients (52%) were classified as AML with myelodysplasia-related features and 3 patients had therapy-related AML. Three patients had received treatment with granulocyte colony stimulation factor, 1 patient liposomal all-trans-retinoic acid, and 2 patients received hypomethylating agents before development of SS. Cytogenetic analysis revealed diploid karyotype in 7 patients (33%); -5/del(5q) in 8 patients (38%): 3 patients had -5/del(5q) as the sole abnormality and 5 patients had -5/del(5q) as part of complex cytogenetics; and complex cytogenetics in 5 patients (24%). Gene mutations in FMS-related tyrosine kinase-3 (FLT3) gene were identified in 7 of 18 evaluable patients (39%), including FLT3-internal tandem duplication in 4 patients and FLT3-D835 tyrosine kinase domain mutation in 3 patients.
  
  
  CONCLUSIONS
  SS occurs in 1% of AML patients; -5/del(5q) karyotype, FLT3 mutations, and AML with myelodysplasia-related features were more frequent among patients with SS.
authors: Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Syed M
authors: SM
authors: Kazmi
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Naveen
authors: N
authors: Pemmaraju
authors: Department of Hematopathology, University of Texas MD Anderson Cancer Center, TX, USA.
authors: Keyur P
authors: KP
authors: Patel
authors: Division of Dermatology, University of California San Diego, San Diego, CA, USA.
authors: Philip R
authors: PR
authors: Cohen
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Naval
authors: N
authors: Daver
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Kathy M
authors: KM
authors: Tran
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Farhad
authors: F
authors: Ravandi
authors: Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Madeleine
authors: M
authors: Duvic
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Guillermo
authors: G
authors: Garcia-Manero
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Sherry
authors: S
authors: Pierce
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Aziz
authors: A
authors: Nazha
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Gautam
authors: G
authors: Borthakur
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Hagop
authors: H
authors: Kantarjian
authors: Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Jorge
authors: J
authors: Cortes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001483:Base Sequence; D001853:Bone Marrow / Q000737:chemistry; D002895:Chromosomes, Human, Pair 5; D020732:Cytogenetic Analysis; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017384:Sequence Deletion; D012867:Skin / Q000737:chemistry; D016463:Sweet Syndrome / Q000235:genetics* / Q000473:pathology; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: Acute febrile neutrophilic dermatosis; FMS-related tyrosine kinase-3; Myelodysplastic syndrome; Neutrophilic dermatosis; −5/del(5q)
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