title: Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation.
abstract: Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis. We report a case highlighting the potential role of ¹⁸F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for therapy monitoring. A 62-year-old man with myelofibrosis underwent FDG-PET/CT for evaluation of the extent of disease before and after allogeneic stem cell transplantation (SCT). PET after SCT demonstrated complete normalization of initially increased bone marrow tracer uptake, consistent with bone marrow biopsy showing complete remission. ¹⁸F-FDG-PET/CT may become a valuable diagnostic tool in myelofibrosis, enabling both sensitive initial staging and therapy monitoring.
authors: Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. t.derlin@uke.de.
authors: Thorsten
authors: T
authors: Derlin
authors: Guntram
authors: G
authors: Büsche
authors: Nicolaus
authors: N
authors: Kröger
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D055728:Primary Myelofibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D011877:Radionuclide Imaging; D033581:Stem Cell Transplantation; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
chemical_list: D019788:Fluorodeoxyglucose F18