title: Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension.
abstract: OBJECTIVE
  Recent hypertension guidelines recommend initiation of treatment with a fixed dose combination of two drugs for more effective and quicker blood pressure control. Few of these have been assessed for efficacy and acceptability. This study examines the short term blood pressure control and acceptability of perindopril, with or without its fixed dose combinations (FDC) with amlodipine and Indapamide in younger patients.
  
  
  METHODS
  In a multicentre prospective observational study, patients with stage 1 hypertension were prescribed perindopril 4 mg per day. Those with stage 2 or 3 hypertension were prescribed a single tablet per day of 4 mg perindopril and 5 mg amlodipine (COVERSYL AM), or 4 mg perindopril and 1.25 mg indapamide (COVERSYL PLUS)for 45 days. The primary outcomes were the frequency of patients achieving blood pressure control and the adverse effect of pedal edema.
  
  
  RESULTS
  Of 426 patients, with a mean age of 45 years, distributed throughout India, and an average (SD) baseline systolic/diastolic blood pressure of 157.2 (13.5)/98.6 (7.4), 303 (71.1%) achieved blood pressure control. Mean (SD) SBP/DBP decreased from baseline by 26.9 (12.6), and DBP by 15.4 (7.2) mm Hg. Few patients discontinued treatment, and the frequency of cough that interfered with sleep and ankle edema was low.
  
  
  CONCLUSIONS
  In patients requiring combination antihypertensive treatment, the regimen of perindopril alone or its FDC with Indapamide or amlodipine reduces blood pressure effectively, resulting in high rates of blood pressure control over the short term, with a low frequency of side effects including cough and pedal edema.
authors: Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India. Electronic address: drsbansal2000@yahoo.com.
authors: Sandeep
authors: S
authors: Bansal
authors: 4718/21, Dayanand Road Ansari Road, Daryaganj, New Delhi 110002, India.
authors: D K
authors: DK
authors: Chauhan
authors: Sri Jayadeva Institute of Cardiology, 9th Block, Jayanagar, Bengaluru 5600069, India.
authors: D
authors: D
authors: Ramesh
authors: New Noor Hospital, Kurla Depot (west), Mumbai 400070, India.
authors: Shahid
authors: S
authors: Barmare
authors: GD Diabetes Hospital and Research Centre, 97, Park Street, Kolkata 700016, India.
authors: Shaibal
authors: S
authors: Chakraborty
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000008:administration & dosage*; D007194:India; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000008:administration & dosage*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D017311:Amlodipine; D007190:Indapamide; D020913:Perindopril
keywords: Amlodipine; FDC; Hypertension; Indapamide
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