title: Fibroblast growth factor 23 and bone mineralisation.
abstract: Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models. Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease (CKD) and may play a critical role in mineral ion disorders and bone metabolism in these patients. Our recent publications have also shown that FGF23 and its cofactor, Klotho, may play an independent role in directly regulating bone mineralisation instead of producing a systematic effect. In this review, we will discuss the new role of FGF23 in bone mineralisation and the pathophysiology of CKD-related bone disorders.
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors: Yu-Chen
authors: YC
authors: Guo
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors: Quan
authors: Q
authors: Yuan
mesh_terms: D002113:Calcification, Physiologic; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D000090265:Klotho Proteins
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
references: Gene. 2001 Jun 27;271(2):171-82
references: 11418238
references: J Clin Endocrinol Metab. 2005 Apr;90(4):2424-7
references: 15687325
references: Kidney Int. 2005 Mar;67(3):1171-8
references: 15698459
references: J Clin Endocrinol Metab. 2005 Mar;90(3):1519-24
references: 15613425
references: J Bone Miner Res. 2003 Jul;18(7):1227-34
references: 12854832
references: South Med J. 2011 May;104(5):348-50
references: 21606715
references: Endocr Relat Cancer. 2011 Jun;18(3):R53-77
references: 21490240
references: Nephrol Dial Transplant. 2012 Feb;27(2):784-90
references: 21730210
references: Biochem Biophys Res Commun. 2001 Feb 2;280(4):1015-20
references: 11162628
references: J Clin Endocrinol Metab. 2009 Feb;94(2):511-7
references: 19050056
references: Clin Orthop Relat Res. 1977;(127):236-47
references: 912987
references: J Bone Miner Res. 2011 Nov;26(11):2634-46
references: 21735478
references: J Clin Endocrinol Metab. 2004 Aug;89(8):3979-82
references: 15292336
references: Kidney Int. 2009 Nov;76(9):977-83
references: 19657329
references: Bone. 2004 Nov;35(5):1192-9
references: 15542045
references: J Clin Invest. 2012 Jul;122(7):2543-53
references: 22728934
references: Bone. 2007 May;40(5):1190-5
references: 17276744
references: Dev Biol. 2007 Mar 1;303(1):191-201
references: 17196192
references: Bone. 2011 Oct;49(4):636-43
references: 21726676
references: Clin J Am Soc Nephrol. 2010 Jan;5(1):110-6
references: 19965548
references: Nat Genet. 2000 Nov;26(3):345-8
references: 11062477
references: J Clin Endocrinol Metab. 2006 Oct;91(10):4037-42
references: 16868048
references: Nephrol Dial Transplant. 2009 Sep;24(9):2792-6
references: 19395730
references: Am J Kidney Dis. 2004 Aug;44(2):250-6
references: 15264182
references: Ther Apher Dial. 2005 Aug;9(4):336-9
references: 16076378
references: J Bone Miner Res. 2006 Aug;21(8):1187-96
references: 16869716
references: Kidney Int. 2006 Dec;70(12):2141-7
references: 17063170
references: Science. 2007 Aug 10;317(5839):803-6
references: 17690294
references: J Am Soc Nephrol. 2006 May;17(5):1305-15
references: 16597685
references: Clin Biochem. 2011 Oct;44(14-15):1264-6
references: 21843522
references: Kidney Int. 2008 Jan;73(1):102-7
references: 17943081
references: Nature. 1997 Nov 6;390(6655):45-51
references: 9363890
references: Matrix Biol. 2004 Nov;23(7):421-32
references: 15579309
references: FASEB J. 2006 Apr;20(6):720-2
references: 16436465
references: FASEB J. 2011 Aug;25(8):2551-62
references: 21507898
references: Am J Kidney Dis. 2004 Sep;44(3):481-7
references: 15332221
references: J Bone Miner Res. 2011 Sep;26(9):2026-35
references: 21590742
references: Immunol Cell Biol. 1995 Dec;73(6):584-9
references: 8713482
references: Bone. 2001 Apr;28(4):430-9
references: 11336925
references: Kidney Int. 2008 Jun;73(12):1355-63
references: 18288097
references: J Bone Miner Metab. 2007;25(6):419-22
references: 17968495
references: Endocrinology. 2011 Nov;152(11):4053-61
references: 21896668
references: J Bone Miner Res. 2014 Mar;29(3):693-704
references: 24038141
references: Cold Spring Harb Perspect Biol. 2013 Jun;5(6). pii: a015958. doi: 10.1101/cshperspect.a015958
references: 23732477
references: Nephrol Dial Transplant. 2004 Jun;19(6):1507-19
references: 15069177
references: J Ren Nutr. 2013 May;23(3):250-4
references: 23611556
references: Am J Physiol Renal Physiol. 2010 Oct;299(4):F882-9
references: 20685823
references: J Biol Chem. 2003 Jan 17;278(3):1998-2007
references: 12421822
references: PLoS One. 2012;7(9):e44161
references: 22970174
references: J Clin Endocrinol Metab. 2007 Jun;92(6):2374-7
references: 17374707
references: J Am Soc Nephrol. 2011 May;22(5):956-66
references: 21436289
references: Kidney Int. 2005 Mar;67(3):1120-5
references: 15698453
references: Hum Mol Genet. 1997 Feb;6(2):165-71
references: 9063736
references: J Bone Miner Metab. 2004;22(3):176-84
references: 15108058
references: Hum Mol Genet. 1997 Apr;6(4):539-49
references: 9097956
references: J Bone Miner Res. 2002 Feb;17(2):311-20
references: 11811562
references: J Clin Invest. 2011 Nov;121(11):4393-408
references: 21985788
references: PLoS Genet. 2008;4(8):e1000154
references: 18688277
references: Nephrol Dial Transplant. 2005 Jul;20(7):1295-8
references: 15840677
references: J Bone Miner Res. 2012 Jan;27(1):38-46
references: 22031097
references: Am J Transplant. 2007 May;7(5):1193-200
references: 17359508
references: Annu Rev Med. 2010;61:91-104
references: 20059333
references: J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):309
references: 18094487
references: Nephrol Dial Transplant. 2012 Jun;27(6):2263-9
references: 22140123
references: J Bone Miner Res. 2010 Oct;25(10):2091-7
references: 20593414
references: Bone Res. 2013 Jun 28;1(2):120-32
references: 26273497
references: Kidney Int. 2003 Dec;64(6):2272-9
references: 14633152
references: J Bone Miner Res. 2004 Mar;19(3):429-35
references: 15040831
references: J Biol Chem. 2006 Mar 10;281(10):6120-3
references: 16436388
references: Crit Rev Oral Biol Med. 2000;11(3):279-303
references: 11021631
references: Nat Genet. 2006 Nov;38(11):1310-5
references: 17033621
references: Endocrinology. 2010 Feb;151(2):492-501
references: 19952276
references: Bone. 2009 Dec;45(6):1161-8
references: 19679205
references: Kidney Int. 2007 Oct;72(8):1004-13
references: 17687259
references: Kidney Int. 2007 Jan;71(1):31-8
references: 17091124
references: J Clin Invest. 2004 Feb;113(4):561-8
references: 14966565
references: J Am Soc Nephrol. 2005 Jul;16(7):2205-15
references: 15917335
references: Trends Mol Med. 2006 Jul;12(7):298-305
references: 16731043
references: Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E254-61
references: 18559986
references: Am J Nephrol. 2011;33(5):421-6
references: 21502756
references: Kidney Int. 2011 Jan;79(1):112-9
references: 20861820
references: J Cell Biochem. 2012 Jul;113(7):2432-41
references: 22573557
references: Exp Cell Res. 2012 May 15;318(9):1040-8
references: 22421513
references: J Bone Miner Metab. 2012 Jan;30(1):1-9
references: 22167381
references: Kidney Int. 2011 Sep;80(5):475-82
references: 21525854
references: J Bone Miner Res. 2008 Jun;23(6):939-48
references: 18282132
references: J Biol Chem. 1996 Jun 21;271(25):15292-7
references: 8663044
references: Calcif Tissue Int. 2011 Aug;89(2):140-50
references: 21633782
references: Nat Genet. 1995 Oct;11(2):130-6
references: 7550339
references: J Endocrinol. 2007 Jan;192(1):261-7
references: 17210763
references: Kidney Int. 2006 Oct;70(8):1486-94
references: 16941023
references: Nephrol Dial Transplant. 2012 Mar;27(3):1050-4
references: 21771755
references: Arch Intern Med. 2008 Aug 11;168(15):1629-37
references: 18695076
references: Nephrol Dial Transplant. 2000 Oct;15(10):1624-30
references: 11007832
references: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1666-71
references: 20080590
references: N Engl J Med. 2008 Aug 7;359(6):584-92
references: 18687639
references: Biochem Biophys Res Commun. 2004 Feb 6;314(2):409-14
references: 14733920
references: PLoS Genet. 2012;8(5):e1002726
references: 22615584
references: J Clin Invest. 2003 Sep;112(5):683-92
references: 12952917
references: Bone. 2007 Jun;40(6):1565-73
references: 17350357
references: Nature. 2006 Dec 7;444(7120):770-4
references: 17086194
references: Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E38-49
references: 16449303
references: FASEB J. 2009 Feb;23(2):433-41
references: 18835926
references: Am J Pathol. 2006 Dec;169(6):2161-70
references: 17148678
references: Nephrol Dial Transplant. 2010 Sep;25(9):3033-8
references: 20368304
references: Kidney Int. 2010 Feb;77(4):292-8
references: 20010546
references: Proc Natl Acad Sci U S A. 2001 May 22;98(11):6500-5
references: 11344269
references: Nephron Clin Pract. 2005;101(2):c94-9
references: 15956805