title: Review: Beta-thalassemia and molecular chaperones.
abstract: Thalassemia is known as a diverse single gene disorder, which is prevalent worldwide. The molecular chaperones are set of proteins that help in two important processes while protein synthesis and degradation include folding or unfolding and assembly or disassembly, thereby helping in cell homeostasis. This review recaps current knowledge regarding the role of molecular chaperones in thalassemia, with a focus on beta thalassemia.
authors: Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia. Electronic address: afshansumera@imu.edu.my.
authors: Afshan
authors: A
authors: Sumera
authors: Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
authors: Ammu
authors: A
authors: Radhakrishnan
authors: Department of Pathology, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
authors: Abdul Aziz
authors: AA
authors: Baba
authors: Department of Pathology, University Putra Malaysia, Kuala Lumpur, Malaysia.
authors: Elizabeth
authors: E
authors: George
mesh_terms: D001798:Blood Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004920:Erythropoiesis / Q000235:genetics; D005786:Gene Expression Regulation; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D017510:Protein Folding; D015398:Signal Transduction; D055542:alpha-Globins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017086:beta-Thalassemia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: C468768:AHSP protein, human; D001798:Blood Proteins; D018840:HSP70 Heat-Shock Proteins; D018832:Molecular Chaperones; D055542:alpha-Globins
keywords: AHSP; HSP-70; Molecular chaperones; Thalassemia