title: Postprocedural Skin Perfusion Pressure Correlates With Clinical Outcomes 1 Year After Endovascular Therapy for Patients With Critical Limb Ischemia.
abstract: BACKGROUND
  Although skin perfusion pressure (SPP) is widely used clinically to predict probability of wound healing, correlation between clinical outcomes and SPP has not been systematically studied.
  
  
  METHODS
  This subanalysis of the prospective multicenter OLIVE registry of patients who received infrainguinal endovascular therapy (EVT) for critical limb ischemia (CLI) assessed the association between clinical outcomes and postoperative SPP in 211 consecutive patients. Logistic regression analysis was performed, with amputation-free survival (AFS), modified major adverse limb events (MALEs), and complete wound healing as dependent variables and postprocedural SPP as independent variable.
  
  
  RESULTS
  Pre- and postprocedural SPP was 28 ± 11 and 46 ± 18 mm Hg, respectively. In logistic regression analysis, postprocedural SPP correlated with 1-year AFS (P = .018), modified MALEs (P < .001), and wound healing (P = .022).
  
  
  CONCLUSIONS
  Postprocedural SPP correlates with clinical outcomes after EVT for patients with CLI.
authors: Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan shiinn.okmt@gmail.com.
authors: Shin
authors: S
authors: Okamoto
authors: Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan.
authors: Osamu
authors: O
authors: Iida
authors: Division of Cardiovascular Medicine, Toho University, Ohashi Medical Center, Tokyo, Japan.
authors: Masato
authors: M
authors: Nakamura
authors: Cardiovascular Center, Kikuna Memorial Hospital, Kanagawa, Japan.
authors: Yasutaka
authors: Y
authors: Yamauchi
authors: Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
authors: Masashi
authors: M
authors: Fukunaga
authors: Department of Cardiology, Kishiwada Tokushukai Hospital, Osaka, Japan.
authors: Yoshiaki
authors: Y
authors: Yokoi
authors: Department of Cardiology, Kokura Memorial Hospital, Fukuoka, Japan.
authors: Yoshimitsu
authors: Y
authors: Soga
authors: Department of Cardiovascular Medicine, Omihachiman Community Medical Center, Shiga, Japan.
authors: Kan
authors: K
authors: Zen
authors: Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Kanagawa, Japan.
authors: Keisuke
authors: K
authors: Hirano
authors: Department of Cardiology, Fukuoka Red Cross Hospital, Fukuoka, Japan.
authors: Nobuhiro
authors: N
authors: Suematsu
authors: Department of Cardiology, Sendai Kousei Hospital, Miyagi, Japan.
authors: Kenji
authors: K
authors: Suzuki
authors: Department of Cardiology, Shin-Koga Hospital, Fukuoka, Japan.
authors: Yoshiaki
authors: Y
authors: Shintani
authors: Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Nagano, Japan.
authors: Yusuke
authors: Y
authors: Miyashita
authors: Cardiovascular Center, Tokeidai Memorial Hospital, Hokkaido, Japan.
authors: Kazushi
authors: K
authors: Urasawa
authors: Wound Treatment Center, Shin-suma General Hospital, Hyogo, Japan.
authors: Ikuro
authors: I
authors: Kitano
authors: Department of Vascular Surgery, Matsuyama Red Cross Hospital, Ehime, Japan.
authors: Terutoshi
authors: T
authors: Yamaoka
authors: Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Tokyo, Japan.
authors: Norihiko
authors: N
authors: Ohura
authors: Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Toshimitsu
authors: T
authors: Hamasaki
authors: Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan.
authors: Masaaki
authors: M
authors: Uematsu
authors: Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Shinsuke
authors: S
authors: Nanto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation; D001794:Blood Pressure; D016638:Critical Illness; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D007564:Japan; D023821:Limb Salvage; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow; D012042:Registries; D012307:Risk Factors; D012867:Skin / Q000098:blood supply*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
keywords: critical limb ischemia; skin perfusion pressure; the endovascular treatment for infrainguinal vessel (OLIVE) Registry