title: Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers.
abstract: Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors.
authors: Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia.
authors: Valery P
authors: VP
authors: Zakharov
authors: Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia.
authors: Ivan A
authors: IA
authors: Bratchenko
authors: Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia.
authors: Dmitry N
authors: DN
authors: Artemyev
authors: Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia.
authors: Oleg O
authors: OO
authors: Myakinin
authors: Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia.
authors: Dmitry V
authors: DV
authors: Kornilin
authors: Samara State Medical University, Department of Oncology, 80 Polevaya Street, Samara 443099, Russia.
authors: Sergey V
authors: SV
authors: Kozlov
authors: Samara State Medical University, Department of Oncology, 80 Polevaya Street, Samara 443099, Russia.
authors: Alexander A
authors: AA
authors: Moryatov
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*