title: Is mitochondrial DNA copy number associated with clinical characteristics and prognosis in gastric cancer?
abstract: Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical value of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present study, we investigated whether alterations in mtCNs might be associated with clinicopathological parameters in GC cases. mtCN was measured in 109 patients with GC by quantitative real-time PCR. Then, correlations with clinicopathological characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared with paired, adjacent, non-cancerous tissue. However, the observed alterations in mtCN were not associated with any clinicopathological characteristics, including age, gender, TN stage, Lauren classification, lymph node metastasis, and depth of invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not significantly associated with the survival of GC patients. In this study, we demonstrated that mtCN was not a significant marker for predicting clinical characteristics or prognosis in GC.
authors: Department of Anatomy, School of Medicine, Keimyung University, Daegu, Republic of Korea E-mail : god98005@dsmc.or.kr.
authors: Hyunsu
authors: H
authors: Lee
authors: Jae-Ho
authors: JH
authors: Lee
authors: Dong-Choon
authors: DC
authors: Kim
authors: IlSeon
authors: I
authors: Hwang
authors: Yu-Na
authors: YN
authors: Kang
authors: Gi-Jeong
authors: GJ
authors: Gwon
authors: In-Jang
authors: IJ
authors: Choi
authors: Shin
authors: S
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D056915:DNA Copy Number Variations / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004272:DNA, Mitochondrial