title: In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells.
abstract: In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 μg/ml was evaluated against eight human cancer cell lines--A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.
authors: Vikas
authors: V
authors: Sharma
authors: Shabir
authors: S
authors: Hussain
authors: Moni
authors: M
authors: Gupta
authors: Ajit Kumar
authors: AK
authors: Saxena
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D027541:Mentha / Q000737:chemistry* / Q000145:classification*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts