title: One-pot synthesis of multifunctional Au@graphene oxide nanocolloid core@shell nanoparticles for Raman bioimaging, photothermal, and photodynamic therapy.
abstract: The paper reports a facile one-pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions for theranosis such as localized surface plasmon resonance, Raman scattering, amphiphilic surface, and photothermal conversion. Synthesis of Au@GON NPs is achieved by simple one-pot reaction in aqueous phase utilizing GON as a reducing and stabilizing agent without any additional reducing agent. The zinc phthalocyanine, a photosensitizer, loaded Au@GON NPs show excellent multifunctional properties for combinational treatment of photothermal and photodynamic therapy in addition to Raman bioimaging with low cytotoxicity.
authors: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
authors: Young-Kwan
authors: YK
authors: Kim
authors: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
authors: Hee-Kyung
authors: HK
authors: Na
authors: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
authors: Seongchan
authors: S
authors: Kim
authors: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
authors: Hongje
authors: H
authors: Jang
authors: Department of Chemistry, Chung-Ang University, Seoul, 156-756, South Korea.
authors: Sung-Jin
authors: SJ
authors: Chang
authors: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 151-747, South Korea.
authors: Dal-Hee
authors: DH
authors: Min
mesh_terms: D003102:Colloids; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use; D010789:Phototherapy; D013059:Spectrum Analysis, Raman; D000068936:Theranostic Nanomedicine; D017967:Zinc Compounds
chemical_list: D003102:Colloids; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D006046:Gold; D006108:Graphite
keywords: Raman spectroscopy; combination therapy; graphene oxide; nanoparticles; surface plasmon resonances