title: [What criteria for an ideal antipsychotic treatment?].
abstract: Antipsychotics are, by definition, drugs to treat all symptomatic dimensions of schizophrenia, even if, following the discovery of chlorpromazine, the effect assessment has been focused on the ability to reduce positive symptoms. Nevertheless, expectations of treatment are no longer limited to only support this one dimension, but integrate the need to treat negative, cognitive and affective symptoms, through long-term modulation of dopamine transmission but also non-dopaminergic pathways. Beyond symptomatic treatment, it is also necessary to have a treatment modifying the evolution course of the disease (disease modifier), acting by a long-term effect on neuropathological and neurochemical abnormalities. The limitation of long-term effect remains the issue of therapeutic observance. Moreover, this concern for efficiency should be at the cost of reduced induction of adverse effects to maximize the benefit/risk ratio. All these dimensions should the components to profile an ideal antipsychotic treatment in 2015.
authors: EA1046, département de pharmacologie médicale, faculté de médecine, université Lille 2, 1, place de Verdun, 59045, Lille cedex, France; CHU de Lille, 2, avenue Oscar-Lambret, 59000, Lille, France. Electronic address: regis.bordet@univ-lille2.fr.
authors: R
authors: R
authors: Bordet
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008134:Long-Term Care; D018377:Neurotransmitter Agents / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine
keywords: Antipsychotic drugs; Antipsychotiques; Effet à long terme; Effets indésirables; Long-term effect; Side-effect; Symptoms; Symptômes