title: Basis of cargo recognition by importin αs: the power of structure.
abstract: In this issue of Structure, Pumroy and colleagues have solved the crystal structure of the influenza virus polymerase PB2 C-terminal domain complexed with different Importin αs. Combining molecular dynamics with structural and biochemical data, the so-far elusive basis for selectivity of binding to distinct different importin αs is beginning to become accessible.
authors: Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.
authors: Gualtiero
authors: G
authors: Alvisi
authors: Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia. Electronic address: david.jans@monash.edu.
authors: David A
authors: DA
authors: Jans
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D019143:Evolution, Molecular; D006801:Humans; D008958:Models, Molecular; D019913:Nuclear Localization Signals / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*; D028901:alpha Karyopherins / Q000737:chemistry*
chemical_list: D019913:Nuclear Localization Signals; D014764:Viral Proteins; D028901:alpha Karyopherins; D012324:RNA-Dependent RNA Polymerase