title: Comparison of hormone receptor status in primary and recurrent breast cancer.
abstract: BACKGROUND
  Systematic treatments such as hormone and chemotherapy are selected according to tumor characteristic after major therapeutic approaches such as surgery. This study attempted to analyze and compare the status of Estrogen Receptor (ER) and Progesterone Receptor (PR) in primary and recurrent sites of breast cancer in patients.
  
  
  METHODS
  We reviewed all medical records of breast cancer women who were treated between January 1995 and December 2008. One hundred eighty two out of 2241 patients (8.12%) had a metastatic breast cancer. Amongst them 48 patients had tumor and biopsy-driven samples, however 13 samples were destroyed and only 35 samples were investigated in this study, therefore 35 malignant biopsy specimens of breast cancer patients were examined by immunohistochemistry essay for ER and PR. Binominal proportional test and Chi square test were conducted to determine the significant correlation between positive cases of hormone receptors among primary and metastases sites.
  
  
  RESULTS
  Hormone Receptor in the primary tumor (HR1) of 9 patients (25.7%) was positive (ER1 and/or PR1) and in the recurrent areas (HR2) of 8 patients (22.9%) was positive (either ER2 or PR2 positive). Kappa coefficients of diagnostic agreement in primary and recurrent cases were 0.077 and 0.125 for estrogen and progesterone, respectively which indicated that the amount of coefficient of agreement is not considerable between primary and recurrent sites.
  
  
  CONCLUSIONS
  The current study indicated that receptor status in recurrent tumors did not pose predictable value based on the analysis of hormone receptors in primary stage, so it is not an appropriate basis to set up therapeutic protocol in the metastatic patients. Therefore, tissue sampling and hormone receptor re-analyzing of metastatic sites should be considered in these cases.
authors: Dept. of Radiation Oncology, Cancer Research Center, Gilan University of Medical Sciences, Rasht, Iran.
authors: Hamid
authors: H
authors: Saeedi Saedi
authors: Dept. of Radiation Oncology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohammad-Reza
authors: MR
authors: Ghavam Nasiri
authors: Dept. of Radiation Oncology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Soodabeh
authors: S
authors: ShahidSales
authors: Dept. of Radiation Oncology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Ali
authors: A
authors: Taghizadeh
authors: Dept. of Radiation Oncology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Nama
authors: N
authors: Mohammadian
keywords: Breast neoplasm; Estrogen receptors; Metastasis; Progesterone receptors
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