title: Dosimetry of a (90)Y-hydroxide liquid brachytherapy treatment approach to canine osteosarcoma using PET/CT.
abstract: A new treatment strategy based on direct injections of (90)Y-hydroxide into the tumor bed in dogs with osteosarcoma was studied. Direct injections of the radiopharmaceutical into the tumor bed were made according to a pretreatment plan established using (18)F-FDG images. Using a special drill, cannulas were inserted going through tissue, tumor and bone. Using these cannulas, direct injections of the radiopharmaceutical were made. The in vivo biodistribution of (90)Y-hydroxide and the anatomical tumor bed were imaged using a time-of-flight (TOF) PET/CT scanner. The material properties of the tissues were estimated from corresponding CT numbers using an electron-density calibration. Radiation absorbed dose estimates were calculated using Monte Carlo methods where the biodistribution of the pharmaceutical from PET images was sampled using a collapsing 3-D rejection technique. Dose distributions in the tumor bed and surrounding tissues were calculated, showing significant heterogeneity with multiple hot spots at injection sites. Dose volume histograms showed that approximately 33.9% of bone and tumor and 70.2% of bone marrow and trabecular bone received an absorbed dose over 200Gy; approximately 3.2% of bone and tumor and 31.0% of bone marrow and trabecular bone received a total dose of over 1000Gy.
authors: Department of Nuclear Engineering, Texas A&M University, College Station, TX 77843-3133, USA.
authors: Jien Jie
authors: JJ
authors: Zhou
authors: Department of Nuclear Engineering, Texas A&M University, College Station, TX 77843-3133, USA.
authors: Arnulfo
authors: A
authors: Gonzalez
authors: Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, TX, USA.
authors: Mark W
authors: MW
authors: Lenox
authors: Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, TX, USA.
authors: Theresa W
authors: TW
authors: Fossum
authors: IsoTherapeutics Group, LLC, Angleton, TX, USA.
authors: R Keith
authors: RK
authors: Frank
authors: IsoTherapeutics Group, LLC, Angleton, TX, USA.
authors: Jaime
authors: J
authors: Simon
authors: The Gabriel Institute, Houston, TX, USA.
authors: Stan
authors: S
authors: Stearns
authors: Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, TX, USA.
authors: Catherine M
authors: CM
authors: Ruoff
authors: Department of Imaging Physics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
authors: Richard E
authors: RE
authors: Wendt
authors: Department of Nuclear Engineering, Texas A&M University, College Station, TX 77843-3133, USA; Texas A&M Institute for Preclinical Studies, Texas A&M University, College Station, TX, USA. Electronic address: akabani@tamu.edu.
authors: Gamal
authors: G
authors: Akabani
keywords: (90)Y; Bone hydroxide; Brachytherapy; Canine; Dog; Osteosarcoma; PET–CT; Radionuclide therapy; Sarcoma Tumor