title: Future water quality monitoring--adapting tools to deal with mixtures of pollutants in water resource management.
abstract: Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.
authors: UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University, Aachen, Germany.
authors: Rolf
authors: R
authors: Altenburger
authors: Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.
authors: Selim
authors: S
authors: Ait-Aissa
authors: Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.
authors: Philipp
authors: P
authors: Antczak
authors: Department of Biological and Environmental Sciences, University of Gothenburg, Carl Skottbergs Gata 22b, 40530 Gothenburg, Sweden.
authors: Thomas
authors: T
authors: Backhaus
authors: Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
authors: Damià
authors: D
authors: Barceló
authors: RWTH Aachen University, Aachen, Germany.
authors: Thomas-Benjamin
authors: TB
authors: Seiler
authors: Institut National de l'Environnement Industriel et des Risques INERIS, BP2, 60550 Verneuil-en-Halatte, France.
authors: Francois
authors: F
authors: Brion
authors: UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors: Wibke
authors: W
authors: Busch
authors: School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.
authors: Kevin
authors: K
authors: Chipman
authors: Water and Soil Quality Research Group, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
authors: Miren López
authors: ML
authors: de Alda
authors: University of Campinas, Limeira, Brazil.
authors: Gisela
authors: G
authors: de Aragão Umbuzeiro
authors: National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors: Beate I
authors: BI
authors: Escher
authors: Centre for Computational Biology and Modelling, University of Liverpool, L69 7ZB, UK.
authors: Francesco
authors: F
authors: Falciani
authors: Faust & Backhaus Environmental Consulting, Fahrenheitstr. 1, 28359 Bremen, Germany.
authors: Michael
authors: M
authors: Faust
authors: Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.
authors: Andreas
authors: A
authors: Focks
authors: Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
authors: Klara
authors: K
authors: Hilscherova
authors: Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.
authors: Juliane
authors: J
authors: Hollender
authors: RWTH Aachen University, Aachen, Germany.
authors: Henner
authors: H
authors: Hollert
authors: Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.
authors: Felix
authors: F
authors: Jäger
authors: UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors: Annika
authors: A
authors: Jahnke
authors: Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.
authors: Andreas
authors: A
authors: Kortenkamp
authors: UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors: Martin
authors: M
authors: Krauss
authors: WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.
authors: Gregory F
authors: GF
authors: Lemkine
authors: IVL Swedish Environmental Research Institute, P.O. Box 53021, 400 14 Göteborg, Sweden.
authors: John
authors: J
authors: Munthe
authors: Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.
authors: Steffen
authors: S
authors: Neumann
authors: Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.
authors: Emma L
authors: EL
authors: Schymanski
authors: Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.
authors: Mark
authors: M
authors: Scrimshaw
authors: University of Bern, Centre for Fish and Wildlife Health, PO Box 8466, CH-3001 Bern, Switzerland.
authors: Helmut
authors: H
authors: Segner
authors: Environmental Institute, Okruzna 784/42, 97241 Kos, Slovak Republic.
authors: Jaroslav
authors: J
authors: Slobodnik
authors: Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
authors: Foppe
authors: F
authors: Smedes
authors: Brunel University, Institute of Environment, Health and Societies, Uxbridge UB8 3PH, United Kingdom.
authors: Subramaniam
authors: S
authors: Kughathas
authors: University of Novi Sad, Faculty of Sciences¸ Trg Dositeja Obradovića, 321000 Novi Sad, Serbia.
authors: Ivana
authors: I
authors: Teodorovic
authors: WatchFrog, Bâtiment Genavenir 3, 1 rue Pierre Fontaine, 91000 Evry, France.
authors: Andrew J
authors: AJ
authors: Tindall
authors: Norwegian Institute for Water Research NIVA, Gaustadalléen 21, N-0349 Oslo, Norway.
authors: Knut Erik
authors: KE
authors: Tollefsen
authors: MAXX Mess- und Probenahmetechnik GmbH, Hechinger Straße 41, D-72414 Rangendingen, Germany.
authors: Karl-Heinz
authors: KH
authors: Walz
authors: School of Biosciences, The University of Birmingham, Birmingham B15 2TT, UK.
authors: Tim D
authors: TD
authors: Williams
authors: Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA Wageningen, The Netherlands.
authors: Paul J
authors: PJ
authors: Van den Brink
authors: Foundation Deltares, Potbus 177, 277 MH Delft, The Netherlands.
authors: Jos
authors: J
authors: van Gils
authors: Masaryk University, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
authors: Branislav
authors: B
authors: Vrana
authors: State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Collaborative Innovation Center for Regional Environmental Quality, Nanjing University, Nanjing 210023, PR China.
authors: Xiaowei
authors: X
authors: Zhang
authors: UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany.
authors: Werner
authors: W
authors: Brack
mesh_terms: D003247:Conservation of Natural Resources / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D060753:Water Quality / Q000592:standards; D062066:Water Resources / Q000706:statistics & numerical data*
chemical_list: D014874:Water Pollutants, Chemical
keywords: Chemical status; Ecological status; Effect-based tools; Mixture toxicity; Priority chemicals; WFD; Water quality