title: Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities.
abstract: One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 µM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 µM.
authors: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Chau Van
authors: CV
authors: Minh
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Hoang Thi
authors: HT
authors: Yen
authors: Phan Van
authors: PV
authors: Kiem
authors: Bui Huu
authors: BH
authors: Tai
authors: Hoang
authors: H
authors: Le Tuan Anh
authors: Truong Thi Thu
authors: TT
authors: Hien
authors: SeonJu
authors: S
authors: Park
authors: Nanyoung
authors: N
authors: Kim
authors: Seung Hyun
authors: SH
authors: Kim
mesh_terms: D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D006131:Growth Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots; D029778:Trichosanthes / Q000737:chemistry*
chemical_list: D003603:Cytotoxins; D006131:Growth Inhibitors; D010936:Plant Extracts