title: Switchable catalytic DNA catenanes.
abstract: Two-ring interlocked DNA catenanes are synthesized and characterized. The supramolecular catenanes show switchable cyclic catalytic properties. In one system, the catenane structure is switched between a hemin/G-quadruplex catalytic structure and a catalytically inactive state. In the second catenane structure the catenane is switched between a catalytically active Mg(2+)-dependent DNAzyme-containing catenane and an inactive catenane state. In the third system, the interlocked catenane structure is switched between two distinct catalytic structures that include the Mg(2+)- and the Zn(2+)-dependent DNAzymes.
authors: Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors: Lianzhe
authors: L
authors: Hu
authors: Chun-Hua
authors: CH
authors: Lu
authors: Itamar
authors: I
authors: Willner
mesh_terms: D002384:Catalysis; D043863:Catenanes / Q000737:chemistry*; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D021881:DNA, Catalytic / Q000737:chemistry*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012815:Signal Processing, Computer-Assisted
chemical_list: D043863:Catenanes; D021881:DNA, Catalytic; D004247:DNA
keywords: DNA switch; DNAzyme; chemiluminescence; hemin/G-quadruplex; machine