title: Antidyslipidemic Effect of Ocimum sanctum Leaf Extract in Streptozotocin Induced Diabetic Rats.
abstract: The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications.
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors: Ishrat
authors: I
authors: Husain
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors: Ramesh
authors: R
authors: Chander
authors: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors: Jitendra Kumar
authors: JK
authors: Saxena
authors: Department of Biochemistry, King George's Medical University, Lucknow, India.
authors: Abbas Ali
authors: AA
authors: Mahdi
authors: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors: Farzana
authors: F
authors: Mahdi
keywords: Anti-dyslipidemic agent; Hypoglycemic agent; Natural antioxidants; Ocimum sanctum; Postheparin lipolytic activity; Streptozotocin induced-diabetes
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