title: Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis.
abstract: Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraventricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of electroacupuncture is associated with the corticotropin release hormone content in the hypothalamus.
authors: Department of Acupuncture and Moxibustion, Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China.
authors: Yunying
authors: Y
authors: Qiao
authors: Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
authors: Fudong
authors: F
authors: Wu
authors: Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
authors: Jian
authors: J
authors: Wang
authors: Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
authors: Xiaolu
authors: X
authors: Cui
authors: Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
authors: Congcong
authors: C
authors: Liu
authors: Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
authors: Xinlong
authors: X
authors: Zhu
keywords: adjuvant arthritis; analgesia; electroacupuncture; endogenous corticotropin release hormone; hypothalamus; neural regeneration; neuron
references: Peptides. 1986 Nov-Dec;7(6):1095-100
references: 2882494
references: Braz J Med Biol Res. 2000 Oct;33(10):1121-31
references: 11004712
references: Ross Fiziol Zh Im I M Sechenova. 2010 Feb;96(2):128-37
references: 20432720
references: J Neuroimmunol. 2003 Aug;141(1-2):30-9
references: 12965251
references: Eur J Pharmacol. 1997 Mar 26;323(1):1-10
references: 9105870
references: Neuroendocrinology. 1987 Jan;45(1):28-36
references: 3492683
references: Acta Physiol Scand. 1989 Sep;137(1):63-71
references: 2477992
references: Fed Proc. 1985 Jan;44(1 Pt 2):237-42
references: 3155696
references: World J Gastroenterol. 2008 Feb 7;14(5):731-6
references: 18205263
references: Sheng Li Xue Bao. 1999 Apr;51(2):140-6
references: 11499007
references: Brain Res. 1996 Jun 17;724(2):149-68
references: 8828564
references: Ross Fiziol Zh Im I M Sechenova. 2007 Nov;93(11):1252-62
references: 18198593
references: Zhen Ci Yan Jiu. 1991;16(1):32-8
references: 1873900
references: Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6096-100
references: 8650225
references: Neurosci Behav Physiol. 2007 May;37(4):363-7
references: 17457531
references: Brain Res. 2011 Apr 6;1383:128-34
references: 21300038
references: Proc Natl Acad Sci U S A. 1985 Nov;82(22):7787-90
references: 2999777
references: Life Sci. 1979 Dec 3;25(23):1957-62
references: 160969
references: Pain. 2000 Jan;84(1):1-12
references: 10601667
references: Neurosci Behav Physiol. 2008 Oct;38(8):759-66
references: 18802775