title: The impact of focusing a program to prevent heavier drinking on a pre-existing phenotype, the low level of response to alcohol.
abstract: BACKGROUND
  Heavy drinking is common during transitions from high school to college. Optimal programs for diminishing risks for high alcohol consumption often tailor the approach to the specific needs of students. This study describes the results of an Internet-based prevention protocol that tailors the information to the risk associated with a pre-existing phenotype, the Low level of Response (Low LR) to alcohol.
  
  
  METHODS
  Using stratified random assignment, 454 freshmen with Low and High LR values were assigned to 2 education groups (LR-based where all examples were given the context of the Low LR model of heavy drinking or a State Of The Art (SOTA) Group where the same lessons were taught but without an emphasis on LR) or a no-intervention Control Group. Individuals in the 2 education groups viewed 50-minute online videos once per week for 4 weeks. Changes in drinking patterns were assessed at Baseline, 4 weeks, and 8 weeks using a 2 (LR status) by 3 (education group) by 3 (time points) analysis of variance, with additional tests for ethnicity and sex.
  
  
  RESULTS
  Low LR participants tended to decrease their usual (p < 0.06) and maximum (p < 0.05) drinks per occasion most prominently when assigned to the LR-based protocol, while those with High LRs improved more in the SOTA Group. The most robust differences were seen when controlling for ethnicity. The effect sizes were small to medium.
  
  
  CONCLUSIONS
  These results support the advantages of carrying out prevention via the Internet and in tailoring the approach to a pre-existing phenotype.
authors: Department of Psychiatry, University of California, San Diego, La Jolla, California.
authors: Marc A
authors: MA
authors: Schuckit
authors: Tom L
authors: TL
authors: Smith
authors: Jelger
authors: J
authors: Kalmijn
authors: Jessica
authors: J
authors: Skidmore
authors: Peyton
authors: P
authors: Clausen
authors: Alexandra
authors: A
authors: Shafir
authors: Gretchen
authors: G
authors: Saunders
authors: Hannah
authors: H
authors: Bystritsky
authors: Kim
authors: K
authors: Fromme
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000503:physiopathology / Q000517:prevention & control*; D019973:Alcohol-Related Disorders / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D010353:Patient Education as Topic; D010641:Phenotype; D013334:Students; D013813:Therapy, Computer-Assisted; D016896:Treatment Outcome; D014495:Universities
keywords: Alcohol; Internet; Level of Response; Prevention
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