title: New C₂₀-gibberellin diterpene from the leaves of Schefflera sessiliflora De P. V.
abstract: From the leaves of Schefflera sessiliflora De P. V., one new C20-gibberellin diterpene 2β,12β-dihydroxygibberellin (12β-hydroxy-GA110 or 2β-hydroxy-GA112) (1), together with three known compounds, trans-tiliroside (2), kaempferol 3-O-β-D-glucuronopyranoside (3), 5-p-trans-coumaroylquinic acid (4), was isolated for the first time from the genus Schefflera by various chromatography methods. Their structures were elucidated by IR, UV, HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolates (2, 3) showed better α-glucosidase inhibitory activity (IC50 = 134.60, 147.10 μM, respectively) than the standard drug acarbose (IC50 = 214.50 μM).
authors: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh City , Vietnam.
authors: Tan Phat
authors: TP
authors: Nguyen
authors: Thi Thao Vy
authors: TT
authors: Tran
authors: Dinh Tri
authors: DT
authors: Mai
authors: Tien Dung
authors: TD
authors: Le
authors: Nhat Minh
authors: NM
authors: Phan
authors: Trong Dat
authors: TD
authors: Bui
mesh_terms: D027481:Araliaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D005875:Gibberellins / Q000737:chemistry* / Q000302:isolation & purification; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014744:Vietnam
chemical_list: D004224:Diterpenes; D005875:Gibberellins; D065089:Glycoside Hydrolase Inhibitors
keywords: Araliaceae; Schefflera sessiliflora De P. V.; diterpene; gibberellin; α-glucosidase inhibition