title: De novo hepatitis B virus infection after pediatric liver transplantations with hepatitis B core antibody-positive donors: a single-center 20-yr experience.
abstract: DNHB is common in countries with high prevalence of hepatitis B, and therefore, contracting hepatitis B after LT with HBcAb(+) grafts is a major concern. We studied DNHB in 247 children (aged <18 yr) who underwent LT from 1994 to 2013. Sixty-six of 247 recipients received HBcAb(+) donor grafts. The incidence of DNHB was 5.7% (14 of 247 children) and that in HBcAb(+) donor grafts was 19.7% (13 of 66 children). The incidence of DNHB without LAM prophylaxis was 31.3% (nine of 29 children), while that with prophylaxis was 10.8% (four of 37 children). LAM prophylaxis negatively correlated with DNHB by Cox regression analysis (p = 0.028, odds ratio = 0.258). Among 13 DNHB patients with HBcAb(+) donor grafts, eight recovered from DNHB and four showed the emergence of LAM resistance. There was no DNHB-related graft failure. This study showed that HBcAb(+) donor graft was associated with development of DNHB, and use of LAM prophylaxis decreased the incidence of DNHB with HBcAb(+) graft.
authors: Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
authors: Yeoun Joo
authors: YJ
authors: Lee
authors: Seak Hee
authors: SH
authors: Oh
authors: Kyung Mo
authors: KM
authors: Kim
authors: Seung Min
authors: SM
authors: Song
authors: Jung-Man
authors: JM
authors: Namgoong
authors: Dae Yeon
authors: DY
authors: Kim
authors: Sung-Gyu
authors: SG
authors: Lee
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006509:Hepatitis B / Q000150:complications / Q000209:etiology*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006515:Hepatitis B virus; D006801:Humans; D015994:Incidence; D019259:Lamivudine / Q000627:therapeutic use; D017093:Liver Failure / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D016016:Proportional Hazards Models; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D006510:Hepatitis B Antibodies; D019259:Lamivudine
keywords: Korea; child; hepatitis B core antigen; liver transplantation