title: Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China.
abstract: We characterized two novel highly pathogenic H5N6 influenza viruses isolated from Chinese poultry in 2013. Genomic analysis showed that both isolates were reassortants, and derived their genes from H5 and H6 subtype viruses found in poultry in China. The virulence of the two isolates was examined in chickens and mice, and both isolates were found to be highly pathogenic in chickens and only moderately virulent for mice. Our results show that continued circulation of these viruses could endanger both avian species and humans.
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Haibo
authors: H
authors: Wu
authors: Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
authors: Rufeng
authors: R
authors: Lu
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Xiaorong
authors: X
authors: Peng
authors: Animal Husbandry and Veterinary Institute, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China.
authors: Lihua
authors: L
authors: Xu
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Linfang
authors: L
authors: Cheng
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Xiangyun
authors: X
authors: Lu
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Changzhong
authors: C
authors: Jin
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Tiansheng
authors: T
authors: Xie
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
authors: Hangping
authors: H
authors: Yao
authors: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: flwnp2013@163.com.
authors: Nanping
authors: N
authors: Wu
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D002681:China / Q000453:epidemiology; D005814:Genes, Viral; D009980:Influenza A virus / Q000145:classification* / Q000235:genetics*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D051379:Mice; D058885:Multilocus Sequence Typing; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000821:virology; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D016865:Reassortant Viruses; D014774:Virulence
keywords: Avian influenza virus; China; H5N6; Poultry; Virus reassortment