title: Nav1.7 protein and mRNA expression in the dorsal root ganglia of rats with chronic neuropathic pain.
abstract: Neuropathic pain was produced by chronic constriction injury of the sciatic nerve in rats. Behavioral tests showed that the thresholds for thermal and mechanical hyperalgesia were significantly reduced in neuropathic pain rats 3-28 days following model induction. The results of immunohistochemistry, western blot assays and reverse transcription-PCR showed that Nav1.7 protein and mRNA expression was significantly increased in the injured dorsal root ganglia. These findings indicated that Nav1.7 might play an important role in the model of chronic neuropathic pain.
authors: Laboratory of Anatomy, Department of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
authors: Chao
authors: C
authors: Liu
authors: Laboratory of Anatomy, Department of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
authors: Jing
authors: J
authors: Cao
authors: Laboratory of Anatomy, Department of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
authors: Xiuhua
authors: X
authors: Ren
authors: Laboratory of Anatomy, Department of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
authors: Weidong
authors: W
authors: Zang
keywords: Nav1.7; dorsal root ganglia; hyperalgesia; neural regeneration; neuropathic pain; regeneration; sensitization; sodium channel
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