title: Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience.
abstract: In multiple myeloma, cytogenetic changes are important predictors of patient outcome. In this setting, the most important changes are deletion 17p, del(17p), and translocation of chromosomes 4 and 14, t(4;14), conferring a poor outcome. However, a certain degree of heterogeneity is observed in the survival of these high-risk patients. We hypothesized that other chromosomal changes may impact the outcome. We retrospectively analyzed a large series of 242 patients displaying either t(4;14) (157 patients) or del(17p) (110 patients), 25 patients presenting both abnormalities, using single nucleotide polymorphism array. In patients with t(4;14), del(1p32), del22q, and >30 chromosomal structural changes negatively impacted progression-free survival (PFS). For overall survival (OS), del(13q14), del(1p32), and the number of chromosomal structural changes worsened the prognosis of patients. For patients with del(17p), del6q worsened the prognosis of patients, whereas trisomy 15 and monosomy 14 were found to have a protective effect on PFS. For OS, del(1p32) worsened the prognosis of patients, whereas having >8 numerical changes was found to have a protective effect on survival. This study, which is the largest series of high-risk patients analyzed with the most modern genomic technique, identified 1 main factor negatively impacting survival: del(1p32).
authors: Laboratory for Genomics in Myeloma, Institut Universitaire du Cancer and University Hospital, Toulouse, France; Centre de Recherche en Cancérologie de Toulouse INSERM U1037, Toulouse, France;
authors: Benjamin
authors: B
authors: Hebraud
authors: Unité Mixte de Génomique du Cancer, University Hospital, Nantes, France; INSERM U892, Nantes, France;
authors: Florence
authors: F
authors: Magrangeas
authors: Laboratory for Genomics in Myeloma, Institut Universitaire du Cancer and University Hospital, Toulouse, France; Centre de Recherche en Cancérologie de Toulouse INSERM U1037, Toulouse, France;
authors: Alice
authors: A
authors: Cleynen
authors: Service d'Epidémiologie, University Hospital, Toulouse, France;
authors: Valerie
authors: V
authors: Lauwers-Cances
authors: Hematology Department, University Hospital, Dijon, France;
authors: Marie-Lorraine
authors: ML
authors: Chretien
authors: Hematology Department, University Hospital, Nancy, France;
authors: Cyrille
authors: C
authors: Hulin
authors: Hematology Department, University Hospital, Lille, France;
authors: Xavier
authors: X
authors: Leleu
authors: Service d'Epidémiologie, University Hospital, Toulouse, France;
authors: Edwige
authors: E
authors: Yon
authors: Hematology Department, University Hospital, Bordeaux, France;
authors: Gerald
authors: G
authors: Marit
authors: Hematology Department, University Hospital, Lyon, France;
authors: Lionel
authors: L
authors: Karlin
authors: Hematology Department, University Hospital, Toulouse, France;
authors: Murielle
authors: M
authors: Roussel
authors: Hematology Department, Institut Paoli-Calmettes, Marseille, France;
authors: Anne-Marie
authors: AM
authors: Stoppa
authors: Hematology Department, Henri Mondor University Hospital, Créteil, France;
authors: Karim
authors: K
authors: Belhadj
authors: Hematology Department, General Hospital, Chalon sur Saone, France;
authors: Laurent
authors: L
authors: Voillat
authors: Hematology Department, Saint-Antoine University Hospital, Paris, France;
authors: Laurent
authors: L
authors: Garderet
authors: Hematology Department, University Hospital, Caen, France;
authors: Margaret
authors: M
authors: Macro
authors: Hematology Department, University Hospital, Dijon, France;
authors: Denis
authors: D
authors: Caillot
authors: Hematology Department, Saint-Antoine University Hospital, Paris, France;
authors: Mohamad
authors: M
authors: Mohty
authors: Hematology Department, University Hospital, Lille, France;
authors: Thierry
authors: T
authors: Facon
authors: Hematology Department, University Hospital, Nantes, France; and.
authors: Philippe
authors: P
authors: Moreau
authors: Hematology Department, University Hospital, Toulouse, France;
authors: Michel
authors: M
authors: Attal
authors: LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
authors: Nikhil
authors: N
authors: Munshi
authors: Laboratory for Genomics in Myeloma, Institut Universitaire du Cancer and University Hospital, Toulouse, France; Centre de Recherche en Cancérologie de Toulouse INSERM U1037, Toulouse, France;
authors: Jill
authors: J
authors: Corre
authors: Unité Mixte de Génomique du Cancer, University Hospital, Nantes, France; INSERM U892, Nantes, France;
authors: Stephane
authors: S
authors: Minvielle
authors: Laboratory for Genomics in Myeloma, Institut Universitaire du Cancer and University Hospital, Toulouse, France; Centre de Recherche en Cancérologie de Toulouse INSERM U1037, Toulouse, France;
authors: Herve
authors: H
authors: Avet-Loiseau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014178:Translocation, Genetic
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