title: Ex vivo lung perfusion - state of the art in lung donor pool expansion.
abstract: Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusion (EVLP) already demonstrated its value in identification of transplantable grafts from the higher risk donor pool. Moreover, lungs from EVLP did not show significantly different postoperative results compared to standard criteria lungs. This could be explained by the reduction of the ischemia-reperfusion injury through EVLP application. The aim of this article is to review technical characteristics and the growing clinical EVLP experience with special attention to EVLP application for donation after cardiac death (DCD) lungs.
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Aron-Frederik
authors: AF
authors: Popov
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Anton
authors: A
authors: Sabashnikov
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Nikhil P
authors: NP
authors: Patil
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Mohamed
authors: M
authors: Zeriouh
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Prashant N
authors: PN
authors: Mohite
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Bartlomiej
authors: B
authors: Zych
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Diana Garcia
authors: DG
authors: Saez
authors: Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
authors: Bastian
authors: B
authors: Schmack
authors: Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
authors: Arjang
authors: A
authors: Ruhparwar
authors: Department of Cardiovascular Surgery, Charite University Medicine, Berlin, Germany.
authors: Pascal M
authors: PM
authors: Dohmen
authors: Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
authors: Matthias
authors: M
authors: Karck
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Andre R
authors: AR
authors: Simon
authors: Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
authors: Alexander
authors: A
authors: Weymann
mesh_terms: D006801:Humans; D008168:Lung / Q000502:physiology*; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000379:methods*
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