title: Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia--the PreOS study protocol.
abstract: OBJECTIVE
  To assess how routine clinical use of the Roche fully automated Elecsys® sFlt-1/PlGF test changes decision-making of physicians to hospitalize pregnant women with suspected preeclampsia.
  
  
  METHODS
  The Preeclampsia Open Study (PreOS) study is a multicenter, prospective, open-label, non-interventional study in 150 women showing signs and symptoms of preeclampsia (suspected preeclampsia). Physicians record their intended procedures before and after knowledge of participants' sFlt-1/PlGF ratio. The study is conducted at five investigational sites in Germany and Austria.
  
  
  CONCLUSIONS
  The PreOS study will provide evidence on how sFlt-1/PlGF ratio testing influences clinical decision-making in women with suspected preeclampsia in real-world clinical practice.
authors: Roche Diagnostics International Ltd , Rotkreuz , Switzerland .
authors: Martin
authors: M
authors: Hund
authors: Wilma
authors: W
authors: Verhagen-Kamerbeek
authors: Manfred
authors: M
authors: Reim
authors: Diethelm
authors: D
authors: Messinger
authors: Reinhard
authors: R
authors: van der Does
authors: Holger
authors: H
authors: Stepan
mesh_terms: D000066491:Clinical Decision-Making; D002985:Clinical Protocols; D005260:Female; D006760:Hospitalization; D006801:Humans; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011446:Prospective Studies; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Decision-making; PlGF; hospitalization; preeclampsia; sFlt-1