title: Multimodality treatment by FOLFOX plus HIFU in a case of advanced pancreatic carcinoma. A case report.
abstract: BACKGROUND
  Pancreatic cancer is one of the most aggressive malignant diseases in which the survival rate has not improved in the past 40 years.
  
  
  METHODS
  A fifty-one-year-old male patient with inoperable metastatic pancreatic cancer and low response to chemotherapy with gemcitabine as single therapy underwent palliative high intensity focused ultrasound (HIFU) ablation. Continuing chemotherapy with folinic acid, oxaliplatin and 5-fluorouracil (FOLFOX) was made. Tools, provided by the European Organization for Research and Treatment of Cancer (EORTC) were used to evaluate his quality of life. The Global Health Status improved from 25 to 42 out of 100 and the body mass index (BMI) increased from 14.9 to 18.1 kg/m(2). Measured by the visual analog scale, the pain was reduced from 7 to 2 out of 10. Twelve months after the HIFU ablation, CT revealed decreased size of the tumor and liver lesions.
  
  
  CONCLUSIONS
  FOLFOX plus interventional, physical destruction of the primary tumor by HIFU sufficiently improved the quality of life, reduced pancreatic pain and provided better survival in this case.
authors: Medical University. Pleven, Bulgaria. dobri_dimitrov@abv.bg.
authors: Dobromir
authors: D
authors: Dimitrov
authors: Tihomir
authors: T
authors: Andreev
authors: Hyuliya
authors: H
authors: Feradova
authors: Borislav
authors: B
authors: Ignatov
authors: Kunn
authors: K
authors: Zhou
authors: Colin
authors: C
authors: Johnson
authors: Tashko
authors: T
authors: Delijski
authors: Grigor
authors: G
authors: Gortchev
authors: Slavcho
authors: S
authors: Tomov