title: Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery.
abstract: Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.
authors: Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-921, Republic of Korea. jchung@snu.ac.kr.
authors: P
authors: P
authors: Garg
authors: S
authors: S
authors: Pandey
authors: Hoon
authors: H
authors: Seonwoo
authors: Seungmin
authors: S
authors: Yeom
authors: Yun-Hoon
authors: YH
authors: Choung
authors: Chong-Su
authors: CS
authors: Cho
authors: Pill-Hoon
authors: PH
authors: Choung
authors: Jong
authors: J
authors: Hoon Chung
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism*; D021941:Caveolae / Q000378:metabolism; D004705:Endocytosis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015394:Molecular Structure; D009696:Nucleic Acids / Q000378:metabolism*; D009997:Osmotic Pressure / Q000187:drug effects*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D013499:Surface Properties; D014993:Xylitol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D009696:Nucleic Acids; D011108:Polymers; D014993:Xylitol