title: Innate immunity in solid organ transplantation: an update and therapeutic opportunities.
abstract: Innate immunity is increasingly recognized as a major player in transplantation. In addition to its role in inflammation in the early post-transplant period, innate immunity shapes the differentiation of cells of adaptive immunity, with a capacity to promote either rejection or tolerance. Emerging data indicate that innate allorecognition, a characteristic previously limited to lymphocytes, is involved in allograft rejection. This review briefly summarizes the physiology of each component of the innate immune system in the context of transplantation and presents the current or promising therapeutic applications, such as cellular, anticomplement and anticytokine therapies.
authors: Transplantation Unit, Renal Division, Department of Medicine, CHU de Québec Research Center, Faculty of Medicine, Laval University, 11 Côte du Palais, Québec, QC, Canada.
authors: Stéphanie
authors: S
authors: Béland
authors: Olivier
authors: O
authors: Désy
authors: Patrice
authors: P
authors: Vallin
authors: Caroline
authors: C
authors: Basoni
authors: Sacha A
authors: SA
authors: De Serres
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors; D003182:Complement C5 / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007113:Immunity, Innate; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008264:Macrophages / Q000276:immunology*; D016377:Organ Transplantation; D014181:Transplantation Immunology; D064887:Observational Studies as Topic
chemical_list: D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D003182:Complement C5; D016207:Cytokines; D007166:Immunosuppressive Agents
keywords: Toll-like receptors; complement; cytokines; dendritic cells; innate immunity; monocytes; transplantation