title: Assessing cognition, depression and anxiety in hospitalized patients during pre and post-Bone Marrow Transplantation.
abstract: OBJECTIVE
  Bone Marrow Transplantation is considered one of the main procedures used in the treatment of both malignant and non-malignant diseases. Psychological factors after Bone Marrow Transplantation have an important role in the survival of the patients undergoing this procedure.
  
  
  METHODS
  In the present study, some parameters including depression, anxiety and cognition were assessed during both pre and post-transplantation in patients undergoing Bone Marrow Transplantation. The evaluations were performed by utilizing several questionnaires including Hospital Anxiety and Depression Scale and Wechsler Memory Scale within 72 hours after hospitalization (pre-transplantation) and one month after transplantation (post-transplantation). All patients received intensive chemotherapy during the first 72 hours after hospitalization. Paired t test was used to compare pre and post values. SPSS (version 18) was used to analysis the data. The significance level was defined as p < 0.05.
  
  
  RESULTS
  Twenty one patients who were not receiving any antianxiety agents at least for two weeks prior to and during this study were included. It was noted that anxiety was significantly less at post-transplantation compared to its pre-transplantation level (P = 0.008). However, no significant difference was found between pre and post-transplantation depression. Memory function was significantly improved at post-transplantation compared to pre-transplantation (P = 0.001).
  
  
  CONCLUSIONS
  The authors suggest that the improvement of anxiety and memory status of the patients one month after the bone marrow transplantation is expected even in the absence of consumption of any antianxiety agents. However, antidepressants may be needed to help those patients who undergo bone marrow transplantation.
authors: Faculty of Pharmacy, Tehran University of Medical Science (TUMS), Tehran, Iran.
authors: Mina
authors: M
authors: Shirinbakhsh Masule
authors: Psychiatry and Psychology Research Center,Roozbeh Hospital, Faculty of Medicine, Tehran University of Medical Science (TUMS), Tehran, Iran.
authors: Mohammad
authors: M
authors: Arbabi
authors: Pharmaceutical Care Department, Shariati hospital and, Tehran University of Medical Science (TUMS), Tehran, Iran.
authors: Padideh
authors: P
authors: Ghaeli
authors: Research Center for Rational Use of Drugs, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science (TUMS), Tehran, Iran.
authors: Molouk
authors: M
authors: Hadjibabaie
authors: Pharmaceutical Care Department, Shariati hospital and, Tehran University of Medical Science (TUMS), Tehran, Iran.
authors: Hasan
authors: H
authors: Torkamandi
keywords: Anxiety; Wechsler memory scale; bone marrow transplantation; cognition; depression; hospital anxiety and depression scale
references: J Clin Oncol. 2000 Apr;18(7):1539-49
references: 10735903
references: Bone Marrow Transplant. 2002 Jun;29(11):917-25
references: 12080358
references: Blood. 1992 Aug 1;80(3):825-30
references: 1638031
references: Psychooncology. 2008 May;17(5):480-7
references: 17879971
references: J Coll Physicians Surg Pak. 2007 Feb;17(2):98-100
references: 17288856
references: JAMA. 2004 May 19;291(19):2335-43
references: 15150205
references: Blood. 2004 Nov 15;104(10):3386-92
references: 15251983
references: Cancer. 2002 Jul 1;95(1):183-92
references: 12115332
references: Cancer Pract. 1999 Jul-Aug;7(4):190-7
references: 10687584
references: Br J Haematol. 2000 Sep;110(3):614-9
references: 10997973
references: J Clin Oncol. 1994 Apr;12(4):820-6
references: 8151324
references: Bone Marrow Transplant. 2005 Oct;36(8):695-702
references: 16086044
references: Psychiatry Clin Neurosci. 2003 Feb;57(1):91-6
references: 12519460
references: Psychooncology. 2009 Feb;18(2):113-27
references: 18677717
references: J Clin Oncol. 2000 Mar;18(5):1004-11
references: 10694550