title: I2- or NBS-catalyzed highly efficient α-hydroxylation of ketones with dimethyl sulfoxide.
abstract: An efficient method for the direct preparation of high synthetic valuable α-hydroxycarbonyls is described. The simple and readily available I2 or NBS was used as catalyst. DMSO acts as the oxidant, oxygen source, and solvent. A diverse range of tertiary Csp(3)-H bonds as well as more challenging secondary Csp(3)-H bonds could be hydroxylated in this transformation. The reaction is mild, less toxic and easy to perform.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Xue Yuan Road 38, Beijing 100191, China.
authors: Yu-Feng
authors: YF
authors: Liang
authors: Kai
authors: K
authors: Wu
authors: Song
authors: S
authors: Song
authors: Xinyao
authors: X
authors: Li
authors: Xiaoqiang
authors: X
authors: Huang
authors: Ning
authors: N
authors: Jiao