title: Mercury and metabolic syndrome: a review of experimental and clinical observations.
abstract: A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism's mercury content modulation on MetS pathogenesis should be undertaken.
authors: Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Sovetskaya st., 14, Yaroslavl, 150000, Russia, tinkov.a.a@gmail.com.
authors: Alexey A
authors: AA
authors: Tinkov
authors: Olga P
authors: OP
authors: Ajsuvakova
authors: Margarita G
authors: MG
authors: Skalnaya
authors: Elizaveta V
authors: EV
authors: Popova
authors: Anton I
authors: AI
authors: Sinitskii
authors: Olga N
authors: ON
authors: Nemereshina
authors: Evgenia R
authors: ER
authors: Gatiatulina
authors: Alexandr A
authors: AA
authors: Nikonorov
authors: Anatoly V
authors: AV
authors: Skalny
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism; D050171:Dyslipidemias / Q000139:chemically induced / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D004785:Environmental Pollutants / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008628:Mercury / Q000633:toxicity*; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism; D018384:Oxidative Stress
chemical_list: D004785:Environmental Pollutants; D008628:Mercury; D005978:Glutathione