title: Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.
abstract: OBJECTIVE
  To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS).
  
  
  METHODS
  A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 ± 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 ± 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound.
  
  
  RESULTS
  H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS-mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05).
  
  
  CONCLUSIONS
  Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Jinyan
authors: J
authors: Yang
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Hongxia
authors: H
authors: Li
authors: Feinberg School of Medicine, The Ann and Robert Lurie, Children's Hospital, Chicago, IL.
authors: Todd
authors: T
authors: Ochs
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Juan
authors: J
authors: Zhao
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Qingyou
authors: Q
authors: Zhang
authors: Department of Pediatrics, Shijitan Hospital, The Capital Medical University, Beijing, P. R. China.
authors: Shuxu
authors: S
authors: Du
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Yonghong
authors: Y
authors: Chen
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Ping
authors: P
authors: Liu
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Yuli
authors: Y
authors: Wang
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Xueli
authors: X
authors: Feng
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China.
authors: Chunyu
authors: C
authors: Zhang
authors: Department of Physiology and Pathophysiology, Peking University Health Sciences Center, Beijing, P. R. China.
authors: Chaoshu
authors: C
authors: Tang
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China; Key Laboratory of Cardiovascular Sciences, Ministry of Education, Beijing, P. R. China.
authors: Junbao
authors: J
authors: Du
authors: Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China. Electronic address: jinhongfang51@126.com.
authors: Hongfang
authors: H
authors: Jin
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004562:Electrocardiography; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D008297:Male; D012372:ROC Curve; D019462:Syncope, Vasovagal / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D018667:Tilt-Table Test
chemical_list: D015415:Biomarkers; D006862:Hydrogen Sulfide