title: Investigating the influence of Na+ and Sr2+ on the structure and solubility of SiO2-TiO2-CaO-Na2O/SrO bioactive glass.
abstract: This study was conducted to determine the influence that network modifiers, sodium (Na+) and strontium (Sr2+), have on the solubility of a SiO2-TiO2-CaO-Na2O/SrO bioactive glass. Glass characterization determined each composition had a similar structure, i.e. bridging to non-bridging oxygen ratio determined by X-ray photoelectron spectroscopy. Magic angle spinning nuclear magnetic resonance (MAS-NMR) confirmed structural similarities as each glass presented spectral shifts between -84 and -85 ppm. Differential thermal analysis and hardness testing revealed higher glass transition temperatures (Tg 591-760 °C) and hardness values (2.4-6.1 GPa) for the Sr2+ containing glasses. Additionally the Sr2+ (~250 mg/L) containing glasses displayed much lower ion release rates than the Na+ (~1,200 mg/L) containing glass analogues. With the reduction in ion release there was an associated reduction in solution pH. Cytotoxicity and cell adhesion studies were conducted using MC3T3 Osteoblasts. Each glass did not significantly reduce cell numbers and osteoblasts were found to adhere to each glass surface.
authors: Inamori School of Engineering, Alfred University, Alfred, NY, 14802, USA.
authors: Y
authors: Y
authors: Li
authors: L M
authors: LM
authors: Placek
authors: A
authors: A
authors: Coughlan
authors: F R
authors: FR
authors: Laffir
authors: D
authors: D
authors: Pradhan
authors: N P
authors: NP
authors: Mellott
authors: A W
authors: AW
authors: Wren
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D017610:Calcium Compounds / Q000737:chemistry; D002448:Cell Adhesion; D002470:Cell Survival / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010087:Oxides / Q000737:chemistry; D056951:Photoelectron Spectroscopy; D012964:Sodium / Q000737:chemistry; D017670:Sodium Compounds / Q000737:chemistry; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013324:Strontium / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D010087:Oxides; D017670:Sodium Compounds; C558454:bioactive SrO-SiO2 glass; C009495:titanium dioxide; C096707:sodium oxide; D012964:Sodium; C016538:lime; D014025:Titanium; D013324:Strontium
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