title: Metabolism and metabolites of polychlorinated biphenyls.
abstract: Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable metabolites are formed in the processes of biotransformation in biota in general, and in humans in particular. The aim of this document is to provide an overview of PCB metabolism, and to identify the metabolites of concern and their occurrence. Emphasis is given to mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood. Potential intracellular targets and health risks are also discussed.
authors: Department of Pharmaceutical Sciences & Experimental Therapeutics, University of Iowa , Iowa City, IA , USA.
authors: Fabian A
authors: FA
authors: Grimm
authors: Dingfei
authors: D
authors: Hu
authors: Izabela
authors: I
authors: Kania-Korwel
authors: Hans-Joachim
authors: HJ
authors: Lehmler
authors: Gabriele
authors: G
authors: Ludewig
authors: Keri C
authors: KC
authors: Hornbuckle
authors: Michael W
authors: MW
authors: Duffel
authors: Åke
authors: Å
authors: Bergman
authors: Larry W
authors: LW
authors: Robertson
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004785:Environmental Pollutants / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000633:toxicity; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
keywords: PCB methyl sulfones; PCB sulfates; human exposure; hydroxylated PCBs; polychlorobiphenylols; reactive intermediates
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