title: Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism.
abstract: Nuclear receptor coactivators (NCOAs) are multifunctional transcriptional coregulators for a growing number of signal-activated transcription factors. The members of the p160 family (NCOA1/2/3) are increasingly recognized as essential and nonredundant players in a number of physiological processes. In particular, accumulating evidence points to the pivotal roles that these coregulators play in inflammatory and metabolic pathways, both under homeostasis and in disease. Given that chronic inflammation of metabolic tissues ("metainflammation") is a driving force for the widespread epidemic of obesity, insulin resistance, cardiovascular disease, and associated comorbidities, deciphering the role of NCOAs in "normal" vs "pathological" inflammation and in metabolic processes is indeed a subject of extreme biomedical importance. Here, we review the evolving and, at times, contradictory, literature on the pleiotropic functions of NCOA1/2/3 in inflammation and metabolism as related to nuclear receptor actions and beyond. We then briefly discuss the potential utility of NCOAs as predictive markers for disease and/or possible therapeutic targets once a better understanding of their molecular and physiological actions is achieved.
authors: Hospital for Special Surgery (D.A.R., M.C., I.R.), The David Rosensweig Genomics Center, New York, New York 10021; and Graduate Program in Immunology and Microbial Pathogenesis (D.A.R., I.R.), Weill Cornell Graduate School of Medical Sciences, New York, New York 10021.
authors: David A
authors: DA
authors: Rollins
authors: Maddalena
authors: M
authors: Coppo
authors: Inez
authors: I
authors: Rogatsky
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D056918:Nuclear Receptor Coactivators / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000235:genetics / Q000378:metabolism
chemical_list: D056918:Nuclear Receptor Coactivators
references: Cell. 2002 Dec 27;111(7):931-41
references: 12507421
references: Glia. 2010 Jun;58(8):932-42
references: 20155818
references: Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11776-81
references: 22753499
references: Mol Cell. 2006 Feb 17;21(4):555-64
references: 16483936
references: Trends Immunol. 2014 Mar;35(3):97-104
references: 24239225
references: Science. 1999 Nov 12;286(5443):1368-71
references: 10558993
references: Nat Rev Drug Discov. 2004 Nov;3(11):950-64
references: 15520817
references: Science. 2008 Nov 28;322(5906):1395-9
references: 19039140
references: Nat Rev Immunol. 2014 Jan;14(1):36-49
references: 24362405
references: EMBO J. 1998 Jan 15;17(2):507-19
references: 9430642
references: Mol Cell Biol. 2005 Jul;25(14):5965-72
references: 15988012
references: J Immunol. 2010 Nov 1;185(9):5444-52
references: 20881187
references: J Biol Chem. 2014 Jun 20;289(25):17721-31
references: 24811170
references: Cell Metab. 2014 Jul 1;20(1):26-40
references: 24794975
references: Nature. 2005 Mar 3;434(7029):113-8
references: 15744310
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12
references: 11149950
references: Nature. 1997 Jun 12;387(6634):733-6
references: 9192902
references: Science. 1994 Jun 3;264(5164):1415-21
references: 8197455
references: J Obstet Gynaecol Res. 2011 Oct;37(10):1269-76
references: 21518137
references: Mol Cell. 2010 Feb 12;37(3):321-32
references: 20159552
references: Nat Rev Drug Discov. 2006 Dec;5(12):993-6
references: 17139284
references: J Leukoc Biol. 2002 Mar;71(3):388-400
references: 11867676
references: Nat Rev Cancer. 2009 Sep;9(9):615-30
references: 19701241
references: Trends Immunol. 2007 Dec;28(12):551-8
references: 17981503
references: Nat Rev Immunol. 2005 May;5(5):375-86
references: 15864272
references: Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3611-6
references: 15731352
references: Science. 2005 Sep 16;309(5742):1857-61
references: 16166517
references: Biochim Biophys Acta. 2007 Aug;1771(8):926-35
references: 17433773
references: Mol Cell Biol. 2003 Mar;23(6):1863-73
references: 12612062
references: Mol Cell. 2007 Mar 9;25(5):765-78
references: 17349961
references: Biol Sex Differ. 2011 Jan 04;2(1):1
references: 21208397
references: Cell. 2010 Mar 19;140(6):805-20
references: 20303872
references: Nat Genet. 2007 Dec;39(12):1507-11
references: 17994021
references: Cell Metab. 2010 Dec 1;12(6):606-18
references: 21109193
references: J Infect Dis. 2014 Jul 15;209 Suppl 3:S107-13
references: 24966190
references: Nat Med. 2012 Jul;18(7):1102-11
references: 22660634
references: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16701-6
references: 12481024
references: Mol Cell. 2013 Jan 10;49(1):158-71
references: 23159735
references: Nutr Metab (Lond). 2005 Feb 02;2(1):3
references: 15689240
references: Science. 1995 Nov 24;270(5240):1354-7
references: 7481822
references: Mol Cell Biol. 2002 Aug;22(16):5923-37
references: 12138202
references: Clin Immunol. 2014 Mar;151(1):66-77
references: 24525049
references: Br J Pharmacol. 2006 Jun;148(3):245-54
references: 16604091
references: Mol Cell Biol. 2012 Feb;32(4):730-9
references: 22158970
references: EMBO J. 1998 Jan 2;17(1):232-43
references: 9427757
references: EMBO J. 2002 Aug 1;21(15):4094-103
references: 12145209
references: Nat Rev Immunol. 2006 Jan;6(1):44-55
references: 16493426
references: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17187-92
references: 18957541
references: Lancet. 2009 May 30;373(9678):1905-17
references: 19482216
references: PLoS One. 2012;7(7):e36961
references: 22859932
references: Elife. 2014;3:e02057
references: 24771768
references: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15161-6
references: 10611355
references: Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6379-84
references: 10823921
references: Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
references: 8643509
references: Hum Reprod Update. 2014 Jul-Aug;20(4):467-84
references: 24634322
references: Nat Rev Immunol. 2010 May;10(5):365-76
references: 20414208
references: Crit Care Med. 1997 Jan;25(1):106-10
references: 8989185
references: Nature. 2005 Sep 29;437(7059):759-63
references: 16127449
references: BMC Cancer. 2009;9:330
references: 19758455
references: Endocr Rev. 2006 Dec;27(7):728-35
references: 17018837
references: Endocrinology. 2013 Jan;154(1):150-8
references: 23211707
references: EMBO J. 2006 Jan 11;25(1):108-17
references: 16362036
references: Mol Endocrinol. 2013 Feb;27(2):366-80
references: 23315938
references: J Biol Chem. 2014 Jun 13;289(24):17078-86
references: 24811171
references: Free Radic Biol Med. 2010 Dec 1;49(11):1603-16
references: 20840865
references: Cell Rep. 2014 Feb 27;6(4):633-45
references: 24529706
references: Nat Cell Biol. 2015 Jan;17(1):44-56
references: 25503565
references: Cell Metab. 2010 Nov 3;12(5):496-508
references: 21035760
references: Cell. 1996 May 3;85(3):403-14
references: 8616895
references: Mol Immunol. 2011 Dec;49(3):549-57
references: 22047959
references: Mol Endocrinol. 2006 May;20(5):1138-52
references: 16423883
references: Nature. 2014 Apr 3;508(7494):123-7
references: 24670648
references: Mol Cell Biol. 2008 Apr;28(7):2460-9
references: 18212051
references: Mol Cell Biol. 2010 Oct;30(19):4564-74
references: 20679482
references: Genes Dev. 1994 May 15;8(10):1224-34
references: 7926726
references: Mol Hum Reprod. 1999 Aug;5(8):742-7
references: 10421802
references: J Clin Invest. 1996 Aug 15;98(4):1004-9
references: 8770873
references: Mol Cell. 2006 Aug 4;23(3):297-305
references: 16885020
references: Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11122-7
references: 20534466
references: Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1542-9
references: 20631355
references: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9
references: 12032330
references: Cell Metab. 2006 Feb;3(2):111-22
references: 16459312
references: Trends Biochem Sci. 2015 Jan;40(1):16-24
references: 25435400
references: Cancer Res. 2006 Nov 15;66(22):11039-46
references: 17108143
references: Oncogene. 2013 Jul 25;32(30):3483-90
references: 23208510
references: Mol Cell Biol. 2010 May;30(9):2078-89
references: 20176806
references: J Biol Chem. 2014 Mar 28;289(13):8931-46
references: 24488492
references: J Biol Chem. 2001 Aug 3;276(31):28857-65
references: 11387316
references: Cell Metab. 2012 May 2;15(5):752-63
references: 22560224
references: EMBO J. 1996 Jul 15;15(14):3667-75
references: 8670870
references: Immunity. 2008 Jan;28(1):29-39
references: 18164222
references: Science. 1999 Jun 25;284(5423):2174-7
references: 10381882
references: Mol Cell Biol. 2007 Feb;27(4):1296-308
references: 17158932
references: J Clin Invest. 2011 Jun;121(6):2111-7
references: 21633179
references: Mol Cell Biol. 2007 Jan;27(1):120-34
references: 17043108
references: Mol Cell Biol. 2002 Jun;22(11):3621-32
references: 11997499
references: Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17868-73
references: 17098861
references: Trends Biochem Sci. 2001 Jun;26(6):384-90
references: 11406412
references: Horm Metab Res. 2001 Mar;33(3):121-6
references: 11355743
references: Cell. 1997 Aug 8;90(3):569-80
references: 9267036
references: Cell Metab. 2011 Jan 5;13(1):35-43
references: 21195347
references: Cell. 2010 Mar 19;140(6):871-82
references: 20303877
references: J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):180-5
references: 21414406
references: FASEB J. 2007 Jan;21(1):231-8
references: 17135362
references: Mol Cell. 2008 Sep 26;31(6):835-49
references: 18922467
references: Nature. 1997 Jun 12;387(6634):677-84
references: 9192892
references: Mol Cell. 2014 Apr 24;54(2):245-54
references: 24766888
references: Trends Endocrinol Metab. 2014 Jul;25(7):337-47
references: 24953190
references: Mol Cell Biol. 2000 Jul;20(13):4699-707
references: 10848596
references: Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14616-21
references: 23950223
references: Neuroreport. 2005 May 31;16(8):829-33
references: 15891579
references: J Hepatol. 2011 Aug;55(2):445-52
references: 21184786
references: J Immunol. 2009 Apr 1;182(7):4479-87
references: 19299749
references: EMBO J. 2001 Nov 1;20(21):6071-83
references: 11689447
references: Am J Respir Cell Mol Biol. 2010 Jan;42(1):9-15
references: 19805480
references: Genes Dev. 2000 Jan 15;14(2):121-41
references: 10652267
references: Nat Genet. 2007 Dec;39(12):1512-6
references: 17994019
references: Mol Cell Endocrinol. 2011 Mar 15;335(1):2-13
references: 20398732
references: Nat Rev Endocrinol. 2014 May;10(5):261-75
references: 24366116
references: Nat Rev Immunol. 2011 Nov;11(11):738-49
references: 21984069
references: Science. 1986 Oct 24;234(4775):470-4
references: 3764421
references: Science. 1998 Mar 20;279(5358):1922-5
references: 9506940
references: J Steroid Biochem Mol Biol. 2007 May;104(3-5):237-40
references: 17532621
references: Mol Cell Biol. 2006 Nov;26(21):7846-57
references: 16923966
references: Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18207-12
references: 19820169
references: Trends Endocrinol Metab. 2011 Aug;22(8):333-43
references: 21646028
references: J Biol Chem. 2007 Jul 13;282(28):20059-63
references: 17502367
references: Endocr Rev. 2003 Aug;24(4):488-522
references: 12920152
references: J Biol Chem. 2001 Oct 26;276(43):39736-41
references: 11502741