title: An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model.
abstract: The use of MEMS implantable drug delivery pump device enables one to program the desired drug delivery profile in the device for individualized medicine treatment to patients. In this study, a MEMS drug delivery device is prepared and employed for in vivo applications. 12 devices are implanted subcutaneously into Kunming mice for evaluating their long term biocompatibility and drug-delivery efficiency in vivo. All the mice survived after device implantation surgery procedures. Histological analysis result reveals a normal wound healing progression within the tissues-to-device contact areas. Serum analysis shows that all measured factors are within normal ranges and do not indicate any adverse responses associated with the implanted device. Phenylephrine formulation is chosen and delivered to the abdominal cavity of the mice by using either the implanted MEMS device (experimental group) or the syringe injection method (control group). Both groups show that they are able to precisely control and manipulate the increment rate of blood pressure in the small animals. Our result strongly suggests that the developed refillable implantable MEMS devices will serve as a viable option for future individualized medicine applications such as glaucoma, HIV-dementia and diabetes therapy.
authors: Laboratory Animal Center of the Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.
authors: Yaqian
authors: Y
authors: Liu
authors: Peiyi
authors: P
authors: Song
authors: Jianwei
authors: J
authors: Liu
authors: Danny Jian Hang
authors: DJ
authors: Tng
authors: Rui
authors: R
authors: Hu
authors: Hongyan
authors: H
authors: Chen
authors: Yazhuo
authors: Y
authors: Hu
authors: Cher Heng
authors: CH
authors: Tan
authors: Jianhua
authors: J
authors: Wang
authors: Jing
authors: J
authors: Liu
authors: Ling
authors: L
authors: Ye
authors: Ken-Tye
authors: KT
authors: Yong
mesh_terms: D015526:AIDS Dementia Complex / Q000188:drug therapy; D058646:Adrenergic alpha-1 Receptor Agonists / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D004343:Drug Implants / Q000493:pharmacokinetics / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D010656:Phenylephrine / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D004343:Drug Implants; D010656:Phenylephrine