title: Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series.
abstract: Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Methods. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included. Results. This review covers a total of 450 cases in 76 articles. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. Symptoms of liver damage occur mostly a month or so after taking the medicine, mainly including jaundice, fatigue, anorexia, and yellow or tawny urine. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Conclusion. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. People should be alert to liver damage when taking HSW preparations.
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China.
authors: Xiang
authors: X
authors: Lei
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China.
authors: Jing
authors: J
authors: Chen
authors: Center for Drug Reevaluation, State Food and Drug Administration, Xicheng, Beijing 100045, China.
authors: Jingtian
authors: J
authors: Ren
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China.
authors: Yan
authors: Y
authors: Li
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China.
authors: Jingbo
authors: J
authors: Zhai
authors: Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China.
authors: Wei
authors: W
authors: Mu
authors: Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China.
authors: Li
authors: L
authors: Zhang
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China.
authors: Wenke
authors: W
authors: Zheng
authors: Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng, Beijing 100007, China.
authors: Guihua
authors: G
authors: Tian
authors: Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China ; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
authors: Hongcai
authors: H
authors: Shang
references: J Clin Gastroenterol. 2008 Aug;42(7):861-2
references: 18580499
references: J Ethnopharmacol. 2013 Oct 28;150(1):108-15
references: 23973786
references: Chin J Nat Med. 2012 Jan;10(1):63-7
references: 23302534
references: J Clin Gastroenterol. 2006 Aug;40(7):629-32
references: 16917407
references: Ann Intern Med. 2004 Apr 6;140(7):W30
references: 15069011
references: Intern Med. 2010;49(15):1537-40
references: 20686286
references: Complement Ther Med. 2014 Feb;22(1):70-4
references: 24559819
references: Vnitr Lek. 2012 Dec;58(12):958-62
references: 23691566
references: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Dec;35(12):1442-7
references: 26882605
references: Gut Liver. 2009 Mar;3(1):52-6
references: 20479902
references: Zhongguo Zhong Yao Za Zhi. 2007 Feb;32(4):323-6
references: 17455469
references: J Gastroenterol Hepatol. 2001 Jan;16(1):115-7
references: 11206309
references: Altern Ther Health Med. 2003 Jan-Feb;9(1):72-83
references: 12564354
references: J Pediatr Gastroenterol Nutr. 2005 Aug;41(2):256-8
references: 16056110
references: Vet Hum Toxicol. 1996 Aug;38(4):280-2
references: 8829347
references: Gut Liver. 2011 Dec;5(4):493-9
references: 22195249
references: Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(18):2414-8
references: 20030101