title: Ultrasmall Cu2-x S Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy.
abstract: Monodisperse, ultrasmall (<5 nm) Cu(2-x)S nanodots (u-Cu(2-x)S NDs) with significantly strong near-infrared absorption and conversion are successfully demonstrated for effective deep-tissue photoacoustic imaging-guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u-Cu(2-x)S NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u-Cu(2-x)S NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging-guided photothermal therapy based on u-Cu(2-x)S NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Juan
authors: J
authors: Mou
authors: Tenth People's Hospital of Tongji University, Shanghai, 200072, P.R. China.
authors: Pei
authors: P
authors: Li
authors: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China.
authors: Chengbo
authors: C
authors: Liu
authors: Tenth People's Hospital of Tongji University, Shanghai, 200072, P.R. China.
authors: Huixiong
authors: H
authors: Xu
authors: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P.R. China.
authors: Liang
authors: L
authors: Song
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Jin
authors: J
authors: Wang
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Kun
authors: K
authors: Zhang
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Yu
authors: Y
authors: Chen
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Jianlin
authors: J
authors: Shi
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.
authors: Hangrong
authors: H
authors: Chen
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D003952:Diagnostic Imaging; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D021621:Imaging, Three-Dimensional; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy
chemical_list: D003300:Copper
keywords: CuS; nanodots; photoacoustic imaging; photothermal therapy