title: Treating cancer in older and oldest old patients.
abstract: The so-called "silver tsunami" is a metaphor that the individuals 65 and older represent the most rapidly growing segment of the Western world population. Aging is an ongoing process that leads to the loss of functional reserve of multiple organ systems, increased susceptibility to stress, it is associated with increased prevalence of chronic disease, and functional dependence. Determined by a combination of genetic and environmental factors, this process is highly individualized and poorly reflected in chronologic age. The heterogeneity and the complexity of the older old population represent the main challenge to the treatment of cancer in those patients. We should discern "fit" elderly in whom standard cancer treatment appears to be comparable to a younger population and "unfit" or "frail" elderly, in which the risks of the treatment may overwhelm potential benefits. There are many aspects that have to be assessed before treating an elderly patient, or before to choose the treatment itself. In our review we will try to explain and describe the meaning and the most important aspects related to the oldest old complex patients, and how to manage those patients.
authors: G
authors: G
authors: Colloca
authors: A
authors: A
authors: Corsonello
authors: E
authors: E
authors: Marzetti
authors: L
authors: L
authors: Balducci
authors: F
authors: F
authors: Landi
authors: M
authors: M
authors: Extermann
authors: G
authors: G
authors: Scambia
authors: M
authors: M
authors: Cesari
authors: I
authors: I
authors: Carreca
authors: S
authors: S
authors: Monfardini
authors: Centro Medicina dell'Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, 00168 Rome, Italy, L.go F. Vito 1. giuseppe.colloca@rm.unicatt.it.
authors: R
authors: R
authors: Bernabei
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*