title: The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between the rs7903146 (C/T) polymorphism in the TCF7L2 gene and type 2 diabetes mellitus, in a Southern-Brazilian population.
  
  
  METHODS
  The TCF7L2 rs7903146 polymorphism was genotyped in 953 type 2 diabetic patients and 535 non-diabetic subjects. All subjects were white. The polymorphism was genotyped by Real-Time PCR using TaqMan MGB probes (Life Technologies). Odds ratios (OR) and 95% confidence intervals (CI) were calculated for additive, recessive and dominant inheritance models.
  
  
  RESULTS
  Genotype and allele frequencies of the rs7903146 polymorphism differed significantly between type 2 diabetic patients and non-diabetic subjects (P = 0.001 and P = 0.0001, respectively). The frequency of the minor allele was 38% in type 2 diabetes group and 31% in non-diabetic subjects, and this allele was significantly associated with type 2 diabetes risk (OR = 1.42, 95% CI 1.15 - 1.76 for the dominant model of inheritance). Moreover, the T/T genotype was associated with a higher risk for type 2 diabetes (OR = 1.83, 95% CI 1.3-2.5) than the presence of only one copy of the T allele (OR = 1.31, 95% CI 1.1-1.6). Both results were adjusted for age and gender.
  
  
  CONCLUSIONS
  Our results confirm the association between the TCF7L2 rs7903146 polymorphism and increase risk for type 2 diabetes in Southern-Brazil.
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Taís S
authors: TS
authors: Assmann
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Guilherme C K
authors: GC
authors: Duarte
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Jakeline
authors: J
authors: Rheinheimer
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Lavínia A
authors: LA
authors: Cruz
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Luís H
authors: LH
authors: Canani
authors: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Daisy
authors: D
authors: Crispim
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D001786:Blood Glucose; D015992:Body Mass Index; D001938:Brazil / Q000208:ethnology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D012737:Sex Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D058118:Transcription Factor 7-Like 2 Protein