title: Medical and surgical interventions to improve outcomes in obese women planning for pregnancy.
abstract: Obesity is a known risk factor for infertility in women. The exact mechanism through which obesity is linked to infertility is still not fully understood. Hyperleptinaemia, hyperinsulinaemia and resultant hyperandrogenism are all thought to play a role. Various medical and surgical interventions have been attempted to improve fertility rates in obese women. Encouraging evidence for pharmacotherapy, bariatric surgery and assisted reproduction are yet to be seen. In this chapter, we review the hormonal changes in obesity and the evidence behind medical and surgical interventions to improve fertility in obese women.
authors: Department of Internal Medicine, Yale-New Haven Hospital, St. Raphael Campus, New Haven, CT, USA. Electronic address: anu.sharma25@gmail.com.
authors: Anu
authors: A
authors: Sharma
authors: Faculty of Medical Sciences, University of The West Indies, St Augustine, Trinidad, W.I., Trinidad and Tobago.
authors: Sarasvati
authors: S
authors: Bahadursingh
authors: Faculty of Medical Sciences, University of The West Indies, St Augustine, Trinidad, W.I., Trinidad and Tobago.
authors: Samuel
authors: S
authors: Ramsewak
authors: Faculty of Medical Sciences, University of The West Indies, St Augustine, Trinidad, W.I., Trinidad and Tobago.
authors: Surujpal
authors: S
authors: Teelucksingh
mesh_terms: D050110:Bariatric Surgery; D015444:Exercise; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007247:Infertility, Female / Q000150:complications / Q000628:therapy*; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity / Q000150:complications / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D061217:Weight Reduction Programs
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin
keywords: assisted reproduction; bariatric surgery; female; fertility; obesity; weight loss