title: One Juliet and four Romeos: VeA and its methyltransferases.
abstract: Fungal secondary metabolism has become an important research topic with great biomedical and biotechnological value. In the postgenomic era, understanding the diversity and the molecular control of secondary metabolites (SMs) are two challenging tasks addressed by the research community. Discovery of the LaeA methyltransferase 10 years ago opened up a new horizon on the control of SM research when it was found that expression of many SM gene clusters is controlled by LaeA. While the molecular function of LaeA remains an enigma, discovery of the velvet family proteins as interaction partners further extended the role of the LaeA beyond secondary metabolism. The heterotrimeric VelB-VeA-LaeA complex plays important roles in development, sporulation, secondary metabolism, and pathogenicity. Recently, three other methyltransferases have been found to associate with the velvet complex, the LaeA-like methyltransferase F and the methyltransferase heterodimers VipC-VapB. Interaction of VeA with at least four methyltransferase proteins indicates a molecular hub function for VeA that questions: Is there a VeA supercomplex or is VeA part of a highly dynamic cellular control network with many different partners?
authors: Department of Biology, Maynooth University, National University of Ireland , Maynooth, Ireland.
authors: Özlem
authors: Ö
authors: Sarikaya-Bayram
authors: Center for Forest Mycology Research, Northern Research Station, United States Forest Service , Madison, WI, USA.
authors: Jonathan M
authors: JM
authors: Palmer
authors: Department of Medical Microbiology and Immunology, University of Wisconsin at Madison , Madison, WI, USA.
authors: Nancy
authors: N
authors: Keller
authors: Department of Molecular Microbiology and Genetics, Georg-August Universität Göttingen , Göttingen, Germany.
authors: Gerhard H
authors: GH
authors: Braus
authors: Department of Biology, Maynooth University, National University of Ireland , Maynooth, Ireland.
authors: Özgür
authors: Ö
authors: Bayram
keywords: LaeA; LlmF; VapA–VipC–VapB; VelB–VeA–LaeA; VosA; methyltransferases; secondary metabolism; velvet family
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