title: Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis.
abstract: Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drug-sensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 μg/ml) as well as drug-resistant strains (MIC, 6.25 to 12.5 μg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
authors: Regional Innovation Center, Soonchunhyang University, Asan 336-745, Republic of Korea.
authors: Woong Sik
authors: WS
authors: Jang
authors: Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.
authors: Sukyung
authors: S
authors: Kim
authors: Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.
authors: Biswajit
authors: B
authors: Podder
authors: Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.
authors: Md Anirban
authors: MA
authors: Jyoti
authors: Departments of Life Science and Biotechnology Soonchunhyang University, Asan 336-745, Republic of Korea.
authors: Kung-Woo
authors: KW
authors: Nam
authors: Department of Chemistry, Soonchunhyang University, Asan 336-745, Republic of Korea.
authors: Byung-Eui
authors: BE
authors: Lee
authors: Regional Innovation Center, Soonchunhyang University, Asan 336-745, Republic of Korea.|Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Republic of Korea.
authors: Ho-Yeon
authors: HY
authors: Song
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D002460:Cell Line; D024881:Drug Resistance, Bacterial; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D013629:Tamoxifen