title: Trends in mortality of adult patients diagnosed with myeloid leukemia from 1994 to 2011 in southeastern Brazil.
abstract: OBJECTIVE
  To evaluate trends in mortality among adults with myeloid leukemia in the Vale do Paraíba, State of São Paulo.
  
  
  METHODS
  Data from the Brazilian National Health Service database DATASUS provided the number of deaths caused by myeloid leukemia and the number of inhabitants per year in the Regional Health Division XVII from 1994 to 2011. Registries were categorized according to gender into four age ranges (over 20 years, 20-49, 50-69 and over 70 years) for an estimation of the annual percent change for age-adjusted mortality rates. The percent changes were calculated using the Joinpoint regression analysis model.
  
  
  RESULTS
  Overall, a significant decline per year was demonstrated for the entire sample (over 20 years) across the 18-year period studied (annual percent change: -5.59%; 95% CI: -8.5 to -2.5% for males; p-value<0.05 and -7.02%; 95% CI -11.2 to -2.8% for females; p-value<0.05) with no significant difference between genders. In an analysis using two Joinpoints, significant drops were observed from 1994 to 2001 (annual percent change: -21.22%; 95% confidence interval: -27.9 to -13.9%; p-value<0.05) and from 1994 to 2003 (annual percent change: -12.86%; 95% confidence interval -22.2 to -2.5%; p-value<0.05) for men and women, respectively. The declining trends were greatest for patients aged over 70 years with the age-adjusted mortality rates in younger groups declining non-significantly except for males aged 50-69 years old.
  
  
  CONCLUSIONS
  Our data suggest a significant decline per year in age-adjusted mortality rates of adult patients diagnosed with myeloid leukemia from 1994 to 2011 in the Vale do Paraíba, State of São Paulo.
authors: Centro de Hematologia do Vale, São José dos Campos, SP, Brazil. Electronic address: fcallera@centrodehematologiadovale.com.br.
authors: Fernando
authors: F
authors: Callera
authors: Centro de Hematologia do Vale, São José dos Campos, SP, Brazil.
authors: Alexandra Fernandes
authors: AF
authors: Callera
authors: Centro de Hematologia do Vale, São José dos Campos, SP, Brazil.
authors: Evandro Secchi
authors: ES
authors: Rosa
keywords: Acute myeloid leukemia; BCR-ABL positive; Chronic myelogenous leukemia; Mortality rate; Myeloid leukemia
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