title: Anticancer agents derived from natural cinnamic acids.
abstract: Cancer is the most dangerous disease that causes deaths all over the world. Natural products have afforded a rich source of drugs in a number of therapeutic fields including anticancer agents. Many significant drugs have been derived from natural sources by structural optimization of natural products. Cinnamic acid has gained great interest due to its antiproliferative, antioxidant, antiangiogenic and antitumorigenic potency. Currently it has been observed that cinnamic acid and its analogs such as caffeic acid, sinapic acid, ferulic acid, and isoferulic acid display various pharmacological activities, such as immunomodulation, anti-inflammation, anticancer and antioxidant. They have served to be the major sources of potential leading anticancer compounds. In this review, we focus on the anticancer potency of cinnamic acid derivatives and novel strategies to design these derivatives. We hope this review will be useful for researchers who are interested in developing anticancer agents.
authors: Ping
authors: P
authors: Su
authors: Yaling
authors: Y
authors: Shi
authors: Jinfeng
authors: J
authors: Wang
authors: Xiuxiu
authors: X
authors: Shen
authors: School of Pharmacy, Xi'an Jiaotong University, No. 76, Yanta West Road, 710061, Xi'an, ShaanXi Province, P.R.China. zhj8623@mail.xjtu.edu.cn.
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; C029010:cinnamic acid; C073734:sinapinic acid; C004999:ferulic acid; C040048:caffeic acid; C008180:isoferulic acid