title: Respiratory Syncytial Virus Outbreak in the Basic Military Training Camp of the Republic of Korea Air Force
abstract: An outbreak of acute febrile illness occurred in the Republic of Korea Air Force boot camp from May to July 2011. An epidemiological investigation of the causative agent, which was of a highly infective nature, was conducted.
  
  
  
  Throat swabs were carried out and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) assay was performed to identify possible causative factors.
  
  
  
  The mean age of patients who had febrile illness during the study period was 20.24 years. The multiplex RT-PCR assay identified respiratory syncytial virus (RSV) as the causative agent. The main symptoms were sore throat (76.0%), sputum (72.8%), cough (72.1%), tonsillar hypertrophy (67.9%), and rhinorrhea (55.9%). The mean temperature was 38.75°C and the attack rate among the recruits was 15.7% (588 out of 3750 recruits), while the mean duration of fever was 2.3 days. The prognosis was generally favorable with supportive care but recurrent fever occurred in 10.1% of the patients within a month.
  
  
  
  This is the first epidemiological study of an RSV outbreak that developed in a healthy young adult group. In the event of an outbreak of an acute febrile illness of a highly infective nature in facilities used by a young adult group, RSV should be considered among the possible causative agents.
authors: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea|Aerospace Medical Research Center, Republic of Korea Air Force, Cheongwon, Korea
authors: Won-Ju
authors: WJ
authors: Park
authors: Aerospace Medical Research Center, Republic of Korea Air Force, Cheongwon, Korea|Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju, Korea
authors: Seok-Ju
authors: SJ
authors: Yoo
authors: Aerospace Medical Research Center, Republic of Korea Air Force, Cheongwon, Korea
authors: Suk-Ho
authors: SH
authors: Lee
authors: Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Goyang, Korea
authors: Jae-Woo
authors: JW
authors: Chung
authors: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea
authors: Keun-Ho
authors: KH
authors: Jang
authors: Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea
authors: Jai-Dong
authors: JD
authors: Moon
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001831:Body Temperature; D004196:Disease Outbreaks; D006801:Humans; D008297:Male; D008889:Military Personnel; D060885:Multiplex Polymerase Chain Reaction; D053139:Oseltamivir / Q000627:therapeutic use; D010614:Pharynx / Q000821:virology; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D056910:Republic of Korea / Q000453:epidemiology; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics* / Q000302:isolation & purification; D013183:Sputum / Q000821:virology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D053139:Oseltamivir
keywords: Disease outbreaks; Fever; Military facilities; Military personnel; Respiratory syncytial virus infections
references: Clin Infect Dis. 2001 Sep 15;33(6):792-6
references: 11512084
references: Expert Rev Anti Infect Ther. 2011 Jan;9(1):27-32
references: 21171875
references: JAMA. 2003 Jan 8;289(2):179-86
references: 12517228
references: J Med Virol. 1990 Feb;30(2):117-27
references: 2179469
references: J Infect Dis. 1996 Sep;174(3):456-62
references: 8769600
references: Emerg Infect Dis. 1999 May-Jun;5(3):379-85
references: 10341174
references: Clin Infect Dis. 2005 Aug 1;41(3):311-7
references: 16007526
references: Am J Respir Crit Care Med. 2006 Mar 15;173(6):639-43
references: 16387798
references: J Med Virol. 2006 May;78(5):659-65
references: 16555275
references: N Engl J Med. 2009 Feb 5;360(6):588-98
references: 19196675
references: Influenza Other Respir Viruses. 2007 Sep-Nov;1(5-6):193-7
references: 18846262
references: Epidemiol Infect. 2009 Dec;137(12):1684-6
references: 19366492
references: J Korean Med Sci. 2010 Mar;25(3):342-7
references: 20191030
references: Emerg Infect Dis. 2010 May;16(5):769-75
references: 20409365
references: J Korean Med Sci. 2014 Sep;29(9):1325-7
references: 25246755
references: J Med Virol. 2013 Feb;85(2):348-53
references: 23192884
references: BMC Infect Dis. 2012;12:95
references: 22520624
references: Ann Pharmacother. 2012 Apr;46(4):558-66
references: 22395247
references: Infect Disord Drug Targets. 2012 Apr;12(2):98-102
references: 22335500
references: Expert Rev Vaccines. 2011 Oct;10(10):1415-33
references: 21988307
references: Pediatr Pulmonol. 2011 Apr;46(4):324-47
references: 21438168
references: Lancet. 2010 May 1;375(9725):1545-55
references: 20399493
references: N Engl J Med. 2001 Jun 21;344(25):1917-28
references: 11419430