title: Patterns of cortical thinning in different subgroups of schizophrenia.
abstract: BACKGROUND
  Alterations of cortical thickness have been shown in imaging studies of schizophrenia but it is unclear to what extent they are related to disease phenotype (including symptom profile) or other aspects such as genetic liability, disease onset and disease progression.
  
  
  OBJECTIVE
  To test the hypothesis that cortical thinning would vary across different subgroups of patients with chronic schizophrenia, delineated according to their symptom profiles.
  
  
  METHODS
  We compared high-resolution magnetic resonance imaging data of 87 patients with DSM-IV schizophrenia with 108 controls to detect changes in cortical thickness across the entire brain (P<0.05, false discovery rate-adjusted). The patient group was divided into three subgroups, consisting of patients with predominantly negative, disorganised or paranoid symptoms.
  
  
  RESULTS
  The negative symptoms subgroup showed the most extensive cortical thinning, whereas thinning in the other subgroups was focused in prefrontal and temporal cortical subregions.
  
  
  CONCLUSIONS
  Our findings support growing evidence of potential subtypes of schizophrenia that have different brain structural deficit profiles.
authors: Igor Nenadic, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Rachel A. Yotter, PhD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, and Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, USA; Heinrich Sauer, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Christian Gaser, PhD, Department of Psychiatry and Psychotherapy and Department of Neurology, Jena University Hospital, Jena, Germany.
authors: Igor
authors: I
authors: Nenadic
authors: Igor Nenadic, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Rachel A. Yotter, PhD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, and Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, USA; Heinrich Sauer, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Christian Gaser, PhD, Department of Psychiatry and Psychotherapy and Department of Neurology, Jena University Hospital, Jena, Germany.
authors: Rachel A
authors: RA
authors: Yotter
authors: Igor Nenadic, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Rachel A. Yotter, PhD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, and Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, USA; Heinrich Sauer, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Christian Gaser, PhD, Department of Psychiatry and Psychotherapy and Department of Neurology, Jena University Hospital, Jena, Germany.
authors: Heinrich
authors: H
authors: Sauer
authors: Igor Nenadic, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Rachel A. Yotter, PhD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, and Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, USA; Heinrich Sauer, MD, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Christian Gaser, PhD, Department of Psychiatry and Psychotherapy and Department of Neurology, Jena University Hospital, Jena, Germany.
authors: Christian
authors: C
authors: Gaser
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000473:pathology; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology