title: Effect of pretransplant hepatitis C virus on the development of new-onset diabetes mellitus after transplant in Egyptian living-donor renal allotransplant recipients at Mansoura Urology and Nephrology Center.
abstract: OBJECTIVE
  New-onset diabetes mellitus after transplant is a common complication in renal allograft recipients. Recently, a high prevalence of diabetes mellitus has been reported in patients with chronic hepatitis C virus. The association between hepatitis C and diabetes mellitus is well demonstrated in the general population, but some controversy still exists. This work aimed to study the effect of pretransplant hepatitis C virus on the development of new-onset diabetes mellitus after transplant in Egyptian living-donor renal allotransplant recipients.
  
  
  METHODS
  This retrospective single center study included 913 kidney transplant recipients who were transplanted at Mansoura Urology and Nephrology Center between 2000 and 2010. The patients were divided into 4 groups according to their hepatitis C virus serology and diabetic status.
  
  
  RESULTS
  Pretransplant dialysis duration and number of blood transfusion units were statistically significant among both viremic and nonviremic groups. With respect to induction therapy, a highly statistical significance was observed between the 4 groups regarding presence and type of adjuvant therapy (P < .001). With respect to maintenance immunosuppression, high statistically significant results were observed regarding steroid and rapamycin between the 4 groups (P < .001) with lower significance regarding mycophenolate mofetil (P = .04) but no significance regarding azathioprine, cyclosporine, or tacrolimus therapy. Incidence of new-onset diabetes mellitus after transplant was statistically higher in the viremic than nonviremic group (P < .001).
  
  
  CONCLUSIONS
  There was a positive correlation between incidence of new-onset diabetes mellitus after transplant and positive pretransplant hepatitis C virus status.
authors: From the Department of Dialysis and Transplantation, The Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
authors: Mohamed H
authors: MH
authors: Abbas
authors: Mabrouk I
authors: MI
authors: Ismail
authors: Salem A
authors: SA
authors: El Deeb
authors: Ayman M
authors: AM
authors: Nagib
authors: Nabil M
authors: NM
authors: Hassan
authors: Ayman F
authors: AF
authors: Refaie
authors: Hanzada M
authors: HM
authors: El Maghrabi
authors: Ahmed A
authors: AA
authors: Denewar
authors: Mohamed A
authors: MA
authors: Bakr
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D004534:Egypt; D005260:Female; D006085:Graft Survival; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents