title: Dental anomalies in first-degree relatives of transposed canine probands.
abstract: The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine-first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine-first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that (i) there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives; (ii) first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and (iii) maternal age at birth of the maxillary canine-first premolar transposition probands was significantly higher than that of the palatally displaced canine probands. The results suggest that maxillary canine-first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.
authors: Broadstreet Dental Centre, Hamrun, Malta.
authors: Adriana
authors: A
authors: Bartolo
authors: Department of Public Health, Medical School, University of Malta, Tal-Qroqq, Malta.
authors: Neville
authors: N
authors: Calleja
authors: Dental Institute, Department of Orthodontics, Kings College London, London, UK.
authors: Fraser
authors: F
authors: McDonald
authors: Dental Institute, Department of Orthodontics, Kings College London, London, UK.
authors: Simon
authors: S
authors: Camilleri
mesh_terms: D003481:Cuspid / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005190:Family; D006801:Humans; D011862:Radiography, Panoramic; D014071:Tooth Abnormalities / Q000209:etiology / Q000235:genetics
references: J Dent Res. 2001 May;80(5):1445-50
references: 11437217
references: J Oral Sci. 2012;54(2):197-203
references: 22790413
references: Am J Orthod Dentofacial Orthop. 2002 Dec;122(6):657-60
references: 12490878
references: Birth Defects Res A Clin Mol Teratol. 2004 Sep;70(9):572-9
references: 15368555
references: Br Dent J. 1967 Nov 7;123(9):439-40
references: 5234746
references: Acta Genet Med Gemellol (Roma). 1971 Jan;20(1):23-42
references: 5568109
references: J Am Dent Assoc. 1977 Mar;94(3):544-7
references: 264924
references: J Dent Res. 1977 Dec;56(12):1449-52
references: 277459
references: Arch Oral Biol. 1984;29(5):373-8
references: 6611147
references: Clin Genet. 1988 Dec;34(6):373-81
references: 3233785
references: Eur J Orthod. 1992 Oct;14(5):369-75
references: 1397075
references: Angle Orthod. 1993 Summer;63(2):99-109; discussion 110
references: 8498708
references: Angle Orthod. 1994;64(4):249-56
references: 7978519
references: J Dent Res. 1996 Oct;75(10):1742-6
references: 8955668
references: Angle Orthod. 1998 Jun;68(3):267-74
references: 9622764
references: Br J Orthod. 1998 Aug;25(3):203-8
references: 9800019
references: Obstet Gynecol. 2005 May;105(5 Pt 1):983-90
references: 15863534
references: Eur J Orthod. 2005 Oct;27(5):450-6
references: 16093260
references: Eur J Orthod. 2006 Apr;28(2):145-51
references: 16373452
references: J Dent Res. 2008 Jun;87(6):580-3
references: 18502969
references: Angle Orthod. 2010 Mar;80(2):275-85
references: 19905852
references: Arch Oral Biol. 2009 Dec;54 Suppl 1:S45-51
references: 18715551
references: BMC Med Genet. 2011;12:47
references: 21453505
references: ASDC J Dent Child. 2002 Jan-Apr;69(1):54-8, 12
references: 12119814