title: Aging and DNA methylation.
abstract: In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.
authors: Beckman Research Institute, Duarte 91010, CA, USA. marcjungphd@gmail.com.
authors: Marc
authors: M
authors: Jung
authors: Gerd P
authors: GP
authors: Pfeifer
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D016922:Cellular Senescence; D019175:DNA Methylation / Q000235:genetics*; D004194:Disease / Q000235:genetics; D006801:Humans; D009928:Organ Specificity / Q000235:genetics; D013234:Stem Cells / Q000378:metabolism
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