title: Evaluation of lipoprotein-associated phosholipase A2 and plaque burden/composition in young adults.
abstract: OBJECTIVE
  The total burden of subclinical coronary atherosclerosis is significant in young adults. Serum lipoprotein-associated phospholipase A2 (Lp-PLA2) is an established predictor of morbidity and mortality because of cardiovascular disease. The aim of the present investigation was to evaluate the relationship between subclinical coronary atherosclerosis and serum Lp-PLA2 concentrations in a population of young adults.
  
  
  METHODS
  A total of 261 individuals younger than 45 years of age who had undergone coronary computed tomography angiography were evaluated. The study group included 101 patients in whom coronary computed tomography angiography detected subclinical coronary atherosclerosis; the control group included 160 sex-matched and age-matched healthy control patients.
  
  
  RESULTS
  Serum Lp-PLA2 levels were increased significantly in the study group patients compared with the control patients (15.42±11.88 vs. 8.06±4.32 ng/ml, P<0.001). Furthermore, a positive correlation was identified between the Lp-PLA2 levels and the total number of plaques and diseased arteries (r=0.495, P<0.001, and r=0.621, P<0.001, respectively). The presence of mixed plaque composition was also correlated with the Lp-PLA2 levels (r=0.657, P<0.001). Multivariate regression analysis identified four independently significant predictors of subclinical coronary atherosclerosis: high-sensitivity C-reactive protein levels, tobacco use, uric acid levels, and serum Lp-PLA2 levels.
  
  
  CONCLUSIONS
  The presence of subclinical coronary atherosclerosis is associated independently with Lp-PLA2, and it has potential utility as a novel indicator of cardiovascular disease risk in the young adult population.
authors: aDepartment of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Researh Hospital bDepartment of Cardiology, Medical Faculty, Acıbadem University, Istanbul cDepartment of Cardiology, Medical Faculty, Erciyes University, Kayseri dDepartment of Cardiology, Medical Faculty, Muğla Sıtkı Kocman University, Muğla, Turkey.
authors: Omer
authors: O
authors: Celik
authors: Derya
authors: D
authors: Ozturk
authors: Fatih
authors: F
authors: Akin
authors: Seckin
authors: S
authors: Satilmis
authors: A Arif
authors: AA
authors: Yalcin
authors: Mehmet
authors: M
authors: Erturk
authors: Burak
authors: B
authors: Ayca
authors: Faruk
authors: F
authors: Akturk
authors: Ali
authors: A
authors: Birand
authors: Hamdi
authors: H
authors: Pusuroglu
authors: M Gungor
authors: MG
authors: Kaya
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D014421:Turkey; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human