title: Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis.
abstract: Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1α (MIP-α), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.
authors: Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea.
authors: Jong Seong
authors: 0000-0002-1672-0171
authors: JS
authors: Lee
authors: Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea.
authors: Jae Hoon
authors: JH
authors: Shin
authors: Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea.
authors: Byung-Soon
authors: BS
authors: Choi
mesh_terms: D000368:Aged; D055008:Anthracosis / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D054405:Chemokine CCL3 / Q000097:blood*; D003032:Coal Mining; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; C508606:CXCL8 protein, human; D054405:Chemokine CCL3; C573420:ICAM1 protein, human; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1
keywords: Coal Workers' Pneumoconiosis; Intercellular Adhesion Molecule-1; Interleukin-8; Macrophage Inflammatory Protein-1 Alpha; Progressive Massive Fibrosis
references: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Nov;31(11):801-5
references: 24370286
references: Am J Respir Cell Mol Biol. 1995 Sep;13(3):323-9
references: 7654388
references: Science. 1989 Mar 3;243(4895):1160-5
references: 2466335
references: Cell. 1990 Jul 13;62(1):3-6
references: 2194672
references: Cytometry B Clin Cytom. 2007 Sep;72(5):408-15
references: 17266151
references: Br J Ind Med. 1984 Aug;41(3):334-9
references: 6743580
references: Eur Respir J. 1994 Apr;7(4):736-9
references: 7911765
references: Environ Res. 1990 Jun;52(1):62-76
references: 2161755
references: Am J Respir Cell Mol Biol. 1990 Apr;2(4):321-6
references: 2182081
references: J Immunol. 1999 Jun 15;162(12):7441-5
references: 10358198
references: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Nov;29(11):837-40
references: 22468294
references: Clin Exp Immunol. 1996 Dec;106(3):541-8
references: 8973625
references: Toxicol Lett. 1999 Sep 5;108(2-3):297-302
references: 10511274
references: J Exp Med. 1988 Feb 1;167(2):570-81
references: 3279154
references: J Toxicol Environ Health. 1996 Dec 27;49(6):599-617
references: 8977627
references: J Neurovirol. 2002 Dec;8(6):625-38
references: 12476355
references: Ann Occup Hyg. 1999 Jan;43(1):7-33
references: 10028891
references: Saf Health Work. 2010 Sep;1(1):69-79
references: 22953165
references: Eur Respir J. 2005 Aug;26(2):319-38
references: 16055882
references: Ann Ital Med Int. 1995 Jan-Mar;10(1):14-8
references: 7727201
references: Am Rev Respir Dis. 1990 Mar;141(3):765-88
references: 2155556
references: Am Rev Respir Dis. 1971 Jan;103(1):57-67
references: 5540840
references: J Toxicol Environ Health B Crit Rev. 2006 Sep-Oct;9(5):357-95
references: 16990219
references: Am J Respir Cell Mol Biol. 1993 Mar;8(3):311-8
references: 8383510
references: Am J Respir Cell Mol Biol. 1991 Aug;5(2):155-62
references: 1892646