title: Peptide vaccines for cancer therapy.
abstract: For around four decades, vaccines of different kinds have been developed to treat different types of cancer. However, promising results encountered in the early phase contrasted with the results recorded in clinical studies. Recent discoveries in the vaccine field, adjuvants and delivery systems, and antigen presentation have lead to new patented approaches. The current review is focused on general description of peptide vaccines involving cancer antigen presentation, specific immune response, cell death dependent pathways, and target therapy for modified or mutated oncogenes. A rapid evolving research in the area may evolve in fruitful outcomes in the near future.
authors: Daniela
authors: D
authors: Cerezo
authors: María J
authors: MJ
authors: Peña
authors: Michael
authors: M
authors: Mijares
authors: Gricelis
authors: G
authors: Martínez
authors: Isaac
authors: I
authors: Blanca
authors: Inmunologia, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela. sanctisj@gmail.com.
authors: Juan B
authors: JB
authors: De Sanctis
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010330:Patents as Topic; D022223:Vaccines, Subunit / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D022223:Vaccines, Subunit