title: Onion (Allium cepa L.) peel extract has anti-platelet effects in rat platelets.
abstract: The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation via inhibition of aggregation-inducing molecules, intracellular Ca(2+) and thromboxane A2 (TXA2) by blocking cyclooxygenase-1 (COX-1) and TXA2 synthase (TXAS) activities in a dose-dependent manner. In addition, OPE elevated the formation of cyclic adenosine monophosphate (cAMP), aggregation-inhibiting molecule, but not cyclic guanosine monophosphate (cGMP). High performance liquid chromatography (HPLC) analysis of OPE revealed that OPE contains quercetin, one of the major flavonoids, which has anti-platelet effect. In conclusion, we suggest that OPE is an effective inhibitor of collagen-stimulated platelet aggregation in vitro. Therefore, it can be a promising and safe strategy for anti-cardiovascular diseases.
authors: Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, 685, Gasuwon-dong, Seo-gu, Daejeon 302-718 Korea.
authors: Ju-Ye
authors: JY
authors: Ro
authors: Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, 685, Gasuwon-dong, Seo-gu, Daejeon 302-718 Korea.|Present address: Department of Microbiology and Immunology, Institute of Medical Science, Tokyo University, Minato-ku, Tokyo, 108-8639 Japan.
authors: Jin-Hyeob
authors: JH
authors: Ryu
authors: Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering and Regional Research Center, Inje University, 607, Obang-dong, Gimhae, Gyungnam 621-749 Korea.
authors: Hwa-Jin
authors: HJ
authors: Park
authors: Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, 685, Gasuwon-dong, Seo-gu, Daejeon 302-718 Korea.
authors: Hyun-Jeong
authors: HJ
authors: Cho
keywords: Cyclic adenosine monophosphate; Intracellular Ca2+; Onion peel extract; Platelet aggregation; Quercetin; Thromboxane A2
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