title: Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.
abstract: Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.
authors: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy. bifulco@unisa.it brunoin@unisa.it.
authors: Maria
authors: M
authors: Strocchia
authors: Stefania
authors: S
authors: Terracciano
authors: Maria G
authors: MG
authors: Chini
authors: Antonio
authors: A
authors: Vassallo
authors: Maria C
authors: MC
authors: Vaccaro
authors: Fabrizio
authors: F
authors: Dal Piaz
authors: Antonietta
authors: A
authors: Leone
authors: Raffaele
authors: R
authors: Riccio
authors: Ines
authors: I
authors: Bruno
authors: Giuseppe
authors: G
authors: Bifulco
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008024:Ligands; D017434:Protein Structure, Tertiary; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D018841:HSP90 Heat-Shock Proteins; D008024:Ligands; D011744:Pyrimidinones