title: Relationship between theta-phase gamma-amplitude coupling and attention-deficit/hyperactivity behavior in children.
abstract: The Continuous Performance Test (CPT) is a valuable tool for assessing behavior in attention-deficit/hyperactivity disorder (ADHD). Quantitative electroencephalography (QEEG) is a promising tool for the diagnosis of ADHD. Recently, theta-phase gamma-amplitude coupling (TGC) measurement has received attention because it is a feasible method of assessing brain function. We investigated the relationship between CPT performance and EEG measures such as TGC and theta and gamma activity. EEGs were recorded from 68 volunteers from a camp for hyperactive children using a 19-electrode system. Their TGC, theta and 40 Hz gamma activity were estimated and compared with results obtained on the Korean ADHD Rating Scale (KARS) and the Intermediate Visual and Auditory (IVA) CPT. The results demonstrated significant negative partial correlations between TGC and the IVA CPT, such as the Response Control Quotient (RCQ) and Attention Quotient (AQ). TGC successfully identified the level of dysfunctional interaction of the attention/arousal system at a multi-scale large network level. It is thought that as the TGC increases, the efficacy of the system is very low or dysfunctional. Compensatory hyper-arousal patterns of the dysfunctional attention/arousal system may account for this effect. TGC is a promising neurophysiological marker for ADHD behavior in children.
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Psychiatry, Graduate School, Chung-Ang University, Seoul, South Korea.
authors: Jun Won
authors: JW
authors: Kim
authors: Addiction Brain Center, Eulji Addiction Institute, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea. Electronic address: sonton21@gmail.com.
authors: Jaewon
authors: J
authors: Lee
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors: Hyun-Jin
authors: HJ
authors: Kim
authors: Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea.
authors: Young Sik
authors: YS
authors: Lee
authors: Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea.
authors: Kyung Joon
authors: KJ
authors: Min
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D065818:Gamma Rhythm; D006801:Humans; D008297:Male; D013826:Theta Rhythm
keywords: Attention-deficit/hyperactivity disorder (ADHD); Continuous performance test (CPT); Neurophysiological marker; Quantitative electroencephalography (QEEG); Theta-phase gamma-amplitude coupling (TGC)