title: Synthesis of (+)-crocacin D and simplified bioactive analogues.
abstract: The total synthesis of (+)-crocacin D has been achieved in 15 steps (9 isolated intermediates) and 14% overall yield from commercially available starting materials and using (+)-crocacin C as a key intermediate. A number of simplified analogues and their biological activities are also reported.
authors: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
authors: Adele E
authors: AE
authors: Pasqua
authors: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
authors: Frank D
authors: FD
authors: Ferrari
authors: Department of Medicinal Chemistry, AstraZeneca R&D, Charnwood, Bakewell Rd., Loughborough LE11 5RH, UK.
authors: James J
authors: JJ
authors: Crawford
authors: Syngenta, Jealott's Hill Research Station, Bracknell, Berkshire RG42 6EY, UK.
authors: William G
authors: WG
authors: Whittingham
authors: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: rudi.marquez@glasgow.ac.uk.
authors: Rodolfo
authors: R
authors: Marquez
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001042:Aphids / Q000187:drug effects; D006540:Herbicides / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology
chemical_list: D000577:Amides; D000935:Antifungal Agents; D006540:Herbicides; D007306:Insecticides; C451481:crocacin D
keywords: Anti-fungal; Bio-active; Crocacins; Enamides; Nematocidal