title: Developmental biology. Regional identity of gut stem cells--one gene to rule them all.
abstract: The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.
authors: Division of Developmental Biology and Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
authors: James M
authors: JM
authors: Wells
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming / Q000235:genetics*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D018874:Spheroids, Cellular / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors
references: J Mol Cell Biol. 2012 Dec;4(6):377-85
references: 22679103
references: Dev Cell. 2009 Apr;16(4):588-99
references: 19386267
references: Nature. 1998 Apr 30;392(6679):920-2
references: 9582071
references: Nature. 1997 Mar 6;386(6620):84-7
references: 9052785
references: Development. 2012 Feb;139(3):465-74
references: 22190642
references: Biochim Biophys Acta. 2014 Sep;1839(9):785-92
references: 24953186
references: Nat Commun. 2014 Dec 11;5:5728
references: 25500896
references: Trends Mol Med. 2012 Sep;18(9):555-63
references: 22871898
references: Stem Cells. 2014 May;32(5):1083-91
references: 24496776
references: Cell Stem Cell. 2011 Oct 4;9(4):317-29
references: 21982232