title: Early infantile growth and cardiovascular risks in adolescent Japanese women.
abstract: OBJECTIVE
  Early life events connected with the risk of later disease can occur not only in utero, but also in infancy. In study of the developmental origins of health and disease, the relationship between infantile growth patterns and adolescent body mass index and blood pressure is one of the most important issues to verify.
  
  
  METHODS
  We analyzed the correlation of current body mass index and systolic blood pressure of 168 female college students with their growth patterns in utero and in infancy.
  
  
  RESULTS
  Body mass index and systolic blood pressure in adolescence showed positive correlations with changes in weight-for-age z scores between 1 and 18 months but not with those between 18 and 36 months. Stepwise multiple regression analysis showed that both change in weight-for-age z scores from 1 to 18 months and body mass index at 1 month were significantly and independently associated with systolic blood pressure in adolescence. Body mass index at 36 months was positively correlated with body mass index in adolescence, while body mass index at birth was negatively correlated with body mass index in adolescence.
  
  
  CONCLUSIONS
  Our findings shows that restricted growth in utero and accelerated weight gain in early infancy are associated with the cardiovascular risk factors of high systolic blood pressure and high body mass index in adolescence. In Japan, an increasing proportion of low birth weight infants and accelerated catch-up growth after birth have been observed in recent decades. This might be an alarming harbinger of an increase in diseases related to the developmental origins of health and disease in Japan.
authors: Department of Nutritional Sciences, Faculty of Health and Welfare Science, Nayoro City University, Japan.
authors: Hiroki
authors: H
authors: Ohmi
authors: Department of Nursing, Faculty of Health and Welfare Science, Nayoro City University, Japan.
authors: Chieko
authors: C
authors: Kato
authors: Department of Liberal Arts Education, Faculty of Health and Welfare Science, Nayoro City University, Japan.
authors: Martin
authors: M
authors: Meadows
authors: Department of Liberal Arts Education, Faculty of Health and Welfare Science, Nayoro City University, Japan.
authors: Kazuyuki
authors: K
authors: Terayama
authors: Department of Early Childhood Education, Nayoro City University Junior College, Japan.
authors: Fumiaki
authors: F
authors: Suzuki
authors: Department of Maternal and Child Nursing, School of Nursing and Social Services, Health Sciences University of Hokkaido, Japan.
authors: Michiko
authors: M
authors: Ito
authors: School of Nursing Science, Asahikawa Medical University, Japan.
authors: Yoshikatsu
authors: Y
authors: Mochizuki
authors: Department of Public Health, Graduate School of Medicine, Chiba University, Japan.
authors: Akira
authors: A
authors: Hata
keywords: body mass index; developmental origins of health and disease; early infantile growth; systolic brood pressure
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