title: Penthrox alone versus Penthrox plus periprostatic infiltration of local analgesia for analgesia in transrectal ultrasound-guided prostate biopsy.
abstract: BACKGROUND
  The objective of this study was to compare pain intensity in patients undergoing transrectal ultrasound (TRUS)-guided biopsy of the prostate with Penthrox alone compared with Penthrox plus periprostatic infiltration of local analgesia (PILA).
  
  
  METHODS
  Seventy-two subjects participated in this study after receiving appropriate education. Forty-two patients self-administered inhaled Penthrox (3 mL methoxyflurane) alone for analgesia (Group A), followed by 30 patients who self-administered Penthrox and received PILA with 5 mL of 2% lignocaine. All subjects had TRUS biopsy performed. Immediately after the procedure, patients were asked to rate their pain intensity using a numerical verbal rating scale from 0 to 10.
  
  
  RESULTS
  Baseline characteristics of the two groups were similar. Patients in Group B reported significantly lower post TRUS biopsy median pain intensity of 2 (1-3) compared with Group A subjects who reported a median post TRUS biopsy pain intensity of 3 (2-5) (P = 0.014). A total of 72 men underwent TRUS-guided biopsy. All patients indicated they would be happy to have another TRUS-guided prostate biopsy in the future.
  
  
  CONCLUSIONS
  Our study shows that Penthrox plus PILA shows promise as an efficacious and easily tolerated analgesic technique for outpatient TRUS biopsy, keeping resource use to a minimum. Planning for a multi-centre, double-blind randomized control trial comparing Penthrox plus PILA with PILA alone is presently underway.
authors: Department of Urology, Bairnsdale Regional Health Service, Bairnsdale, Victoria, Australia.|Department of Urology, Alfred Health, Melbourne, Victoria, Australia.
authors: Sean
authors: S
authors: Huang
authors: Department of Urology, Bairnsdale Regional Health Service, Bairnsdale, Victoria, Australia.
authors: Lana
authors: L
authors: Pepdjonovic
authors: Department of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia.|Department of Anaesthesia and Perioperative Medicine, Alfred Health, Melbourne, Victoria, Australia.
authors: Alex
authors: A
authors: Konstantatos
authors: Department of Urology, Bairnsdale Regional Health Service, Bairnsdale, Victoria, Australia.|Department of Surgery, Monash University, Melbourne, Victoria, Australia.|Department of Urology, Monash Health, Melbourne, Victoria, Australia.
authors: Mark
authors: M
authors: Frydenberg
authors: Department of Urology, Bairnsdale Regional Health Service, Bairnsdale, Victoria, Australia.|Department of Urology, Alfred Health, Melbourne, Victoria, Australia.|Department of Surgery, Monash University, Melbourne, Victoria, Australia.
authors: Jeremy
authors: J
authors: Grummet
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008733:Methoxyflurane / Q000008:administration & dosage*; D008875:Middle Aged; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012646:Self Administration; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D008733:Methoxyflurane; D008012:Lidocaine
keywords: analgesia; biopsy; needle; pain management; prostatic neoplasms