title: Radical scavenging activity of Caesalpinia spinosa.
abstract: OBJECTIVE
  To assess protective effects of the tara (Caesalpinia spinosa) extract against hyaluronan (HA) degradation evoked by cupric ions and ascorbate.
  
  
  METHODS
  Uninhibited/inhibited HA degradation was assayed by a decrease in dynamic viscosity of the HA solutions, whereas as a method rotational viscometry was used. To determine radical scavenging capacity of the tara extract, the ABTS and DPPH assays were performed.
  
  
  RESULTS
  The results of rotational viscometry showed remarkable protective effects of the tara extract against the degradation of HA. In the ABTS and DPPH assays the IC50 values of the tara extract 1.59 and 30.8 μg/mL indicated quite high radical scavenging properties.
  
  
  CONCLUSIONS
  The tara extract is an efficient antioxidant as demonstrated by the methods used.
authors: Katarína
authors: K
authors: Valachová
authors: Dominika
authors: D
authors: Topol'ská
authors: Milan
authors: M
authors: Nagy
authors: Carmen
authors: C
authors: Gaidau
authors: Mihaela
authors: M
authors: Niculescu
authors: Ján
authors: J
authors: Matyašovský
authors: Peter
authors: P
authors: Jurkovič
authors: Ladislav
authors: L
authors: Soltés
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D029911:Caesalpinia; D006820:Hyaluronic Acid / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D006820:Hyaluronic Acid