title: Association between lipid ratios and insulin resistance in a Chinese population.
abstract: OBJECTIVE
  To explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population. We also provide the clinical utility of lipid ratios to identify men and women with IR.
  
  
  METHODS
  This cross-sectional study included 614 men and 1055 women without diabetes. Insulin resistance was defined by homeostatic model assessment of IR > 2.69. Lipid ratios included the TG/ high density lipoprotein cholesterol (HDL-C), the total cholesterol (TC)/HDL-C and the low density lipoprotein cholesterol (LDL-C)/HDL -C. Logistic regression models and accurate estimates of the area under the receiver operating characteristic (AUROC) curves were obtained.
  
  
  RESULTS
  In normal-weight men, none of lipid ratios nor TG was associated with IR. In overweight/obese men, normal-weight women and overweight/obese women, the TG/HDL-C, the TC/HDL-C and TG were significantly associated with IR, and the associations were independent of waist circumference. All of the AUROCs for the TG/HDL-C and TG were > 0.7. The AUROCs for TC/HDL-C ratio were 0.69-0.77. The optimal cut-offs for TG/HDL-C were 1.51 in men and 0.84 in women. The optimal cut-offs for TG were 1.78 mmol/L in men and 1.49 mmol/L in women, respectively. In men, the optimal cut-off for LDL-C/HDL-C is 3.80. In women, the optimal cut-off for LDL-C/HDL-C is 3.82.
  
  
  CONCLUSIONS
  The TG/HDL-C, the TC/HDL-C and TG are associated with IR in overweight/obese men, normal-weight and overweight/obese women. The LDL-C/HDL-C is only associated with IR in normal-weight women. The TG/HDL-C and TG might be used as surrogate markers for assessing IR.
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China; Department of Nephrology, First Affiliated Hospital of Inner Mongolia Medical University, Huhehaote, China.
authors: Liying
authors: L
authors: Zhang
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China; Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
authors: Shanying
authors: S
authors: Chen
authors: Department of Rehabilitation, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Aiwen
authors: A
authors: Deng
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Xinyu
authors: X
authors: Liu
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Yan
authors: Y
authors: Liang
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Xiaofei
authors: X
authors: Shao
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Mingxia
authors: M
authors: Sun
authors: Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
authors: Hequn
authors: H
authors: Zou
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
references: Circulation. 2002 Dec 17;106(25):3143-421
references: 12485966
references: Lipids Health Dis. 2010 Dec 07;9:138
references: 21134293
references: PLoS One. 2012;7(12):e50931
references: 23251403
references: Int J Endocrinol. 2012;2012:173281
references: 22792101
references: Diabetes Care. 2011 Aug;34(8):1869-74
references: 21730284
references: Nat Rev Cardiol. 2011 Apr;8(4):197-206
references: 21283149
references: Clin Chem. 1972 Jun;18(6):499-502
references: 4337382
references: Int J Environ Res Public Health. 2014 Jul 29;11(8):7622-35
references: 25075881
references: Circulation. 2011 May 24;123(20):2292-333
references: 21502576
references: Circulation. 1997 Oct 21;96(8):2520-5
references: 9355888
references: J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10
references: 10902785
references: Arch Intern Med. 2001 Dec 10-24;161(22):2685-92
references: 11732933
references: Cardiovasc Diabetol. 2011 Oct 17;10:93
references: 22004541
references: Cardiovasc Diabetol. 2008 Feb 28;7:4
references: 18307789
references: J Am Soc Nephrol. 2004 Nov;15(11):2775-91
references: 15504931
references: Diabetes Care. 1997 Jul;20(7):1183-97
references: 9203460
references: Endocrine. 2014 Aug;46(3):496-504
references: 24190050
references: PLoS One. 2013 Sep 13;8(9):e74058
references: 24058515
references: Metabolism. 2012 Apr;61(4):583-9
references: 22075272
references: Am J Cardiol. 2005 Aug 1;96(3):399-404
references: 16054467
references: Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S460-4
references: 23565467
references: Int J Endocrinol. 2014;2014:105168
references: 25136362
references: Diabetes Care. 1996 Mar;19(3):278-86
references: 8742583
references: Ann Intern Med. 2003 Nov 18;139(10):802-9
references: 14623617
references: Metabolism. 2010 Feb;59(2):299-304
references: 19796777
references: Diabetes. 1988 Dec;37(12):1595-607
references: 3056758
references: Diabetes. 2003 Feb;52(2):463-9
references: 12540622
references: Am J Clin Nutr. 1981 Aug;34(8):1617-21
references: 7270486
references: Int J Obes Relat Metab Disord. 1999 Feb;23(2):116-25
references: 10078844