title: Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis.
abstract: Gastric cardia cancer (GCC) is a highly aggressive disease associated with chronic inflammation. To investigate the relationship between DNA damage response (DDR) and chronic inflammation, we collected 100 non-tumor gastric cardia specimens of Chaoshan littoral, a high-risk region for esophageal and gastric cardia cancer. A significantly higher proportion of severe chronic inflammation was found in dysplastic epithelia (80.9%) in comparison with that in non-dysplastic tissues (40.7%) (P<0.001). Immunohistochemical analysis demonstrated that DNA damage response was parallel with the chronic inflammation degrees from normal to severe inflammation (P<0.05). We found that DNA damage response was progressively increased with the progression of precancerous lesions (P<0.05). These findings provide pathological evidence that persistent chronic inflammation-related DNA damage response may be a driving force of gastric cardia carcinogenesis. Based on these findings, DNA damage response in non-malignant tissues may become a promising biomedical marker for predicting malignant transformation in the gastric cardia.
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Runhua
authors: R
authors: Lin
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|Clinical Laboratory of Ganzhou People's Hospital, Ganzhou, Jiangxi, PR China.
authors: Dejun
authors: D
authors: Xiao
authors: Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Yi
authors: Y
authors: Guo
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Dongping
authors: D
authors: Tian
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Hailong
authors: H
authors: Yun
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Donglin
authors: D
authors: Chen
authors: Institute of Clinical Pathology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, PR China.|The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Min
authors: M
authors: Su
mesh_terms: D000368:Aged; D002299:Cardia / Q000473:pathology; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D002681:China; D002908:Chronic Disease; D004249:DNA Damage; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
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