title: Risk factors of recurrence among 471 Chinese patients with Budd-Chiari syndrome.
abstract: OBJECTIVE
  Budd-Chiari syndrome (BCS) is a rare form of vascular disease. There is limited literature available regarding the prognosis of this disease. The aim of this study was to characterize the cumulative recurrence rates and to investigate the risk factors of recurrence in Chinese patients with BCS.
  
  
  METHODS
  Four hundred and seventy-one patients were diagnosed as having BCS in the Affiliated Hospital of Xuzhou Medical College (Jiangsu, China) between January 2008 and December 2012. Follow-ups were conducted by phone calls or correspondence. Cumulative recurrence rates were assessed with the Kaplan-Meier curves. Independent risk factors of recurrence were calculated with the Cox's proportional hazards regression model.
  
  
  RESULTS
  Four hundred and twenty-five patients with BCS had complete follow-up data, in which 24 patients died, 98 patients had recurrence, with the median duration of follow-up being 19.3 months (range 3 to 61.4). The cumulative 1-, 2-, 3-, 4- and 5-year recurrence rates were 12%, 22%, 27%, 35% and 42%, respectively. Univariable and multivariable Cox's proportional hazards regression models showed that the risk factors of recurrence include: age ≤ 30 years (HR=2.261, 95% CI: 1.412-3.621), differentiated typology (hepatic vein type: HR=1.885, 95% CI: 1.045-3.402; combined type: HR=2.088, 95% CI: 1.233-3.536), elevated lactate dehydrogenase (LDH) levels (HR=1.125, 95% CI: 1.101-1.212) and the Child-Pugh class B/C (B: HR=1.758, 95% CI: 1.057-2.926; C: HR=2.626, 95% CI: 1.396-4.940).
  
  
  CONCLUSIONS
  Regardless of thrombophilia and haematological causes, exceptionally found in Chinese patients, the 5-year recurrence rate of BCS was as high as 42%. Age ≤ 30 years, hepatic vein type, combined type, increased LDH levels and the Child-Pugh class B/C were independent predictors of BCS recurrence.
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. Electronic address: xzgxy888@163.com.
authors: Xiuyin
authors: X
authors: Gao
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China; Department of Medical Records, Anhui Provincial Cancer Hospital, Hefei, Anhui 230031, China. Electronic address: gui916@sina.cn.
authors: Er
authors: E
authors: Gui
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. Electronic address: L23zj@163.com.
authors: Zhaojun
authors: Z
authors: Lu
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. Electronic address: 18796247958@163.com.
authors: Xin
authors: X
authors: Ning
authors: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China. Electronic address: zmh5011@sina.com.
authors: Maoheng
authors: M
authors: Zu
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. Electronic address: xzmczpj1989@sina.com.
authors: Peijin
authors: P
authors: Zhang
authors: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. Electronic address: gxsunny@hotmail.com.
authors: Guixiang
authors: G
authors: Sun
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006502:Budd-Chiari Syndrome / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000208:ethnology / Q000401:mortality; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014654:Vascular Patency
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase