title: Deep Brain Stimulation for Obsessive Compulsive Disorder Reduces Symptoms of Irritable Bowel Syndrome in a Single Patient.
abstract: Irritable bowel syndrome (IBS) is a frequent gastrointestinal disorder that is difficult to treat. We describe findings from evaluation of a woman (55 years old) with obsessive compulsive disorder, which was treated with bilateral deep brain stimulation in the anterior limb of the internal capsule, and IBS. After the brain stimulation treatment she reported substantial relief of her IBS symptoms. This reduction depended on specific stimulation parameters, was reproducible over time, and was not directly associated with improvements in obsessive compulsive disorder symptoms. These observations indicate a specific effect of deep brain stimulation on IBS. This observation confirms involvement of specific brain structures in the pathophysiology of IBS and shows that symptoms can be reduced through modulation of neuronal activity in the central nervous system. Further studies of the effects of brain stimulation on IBS are required.
authors: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany. Electronic address: Berthold.Langguth@medbo.de.
authors: Berthold
authors: B
authors: Langguth
authors: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors: Kornelia
authors: K
authors: Sturm
authors: Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
authors: Thomas C
authors: TC
authors: Wetter
authors: Department of Neurosurgery, University of Regensburg, Regensburg, Germany.
authors: Max
authors: M
authors: Lange
authors: University Psychiatric Center, UPC KULeuven, Leuven, Belgium.
authors: Loes
authors: L
authors: Gabriels
authors: Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California.
authors: Emeran A
authors: EA
authors: Mayer
authors: Department of Neurosurgery, University of Regensburg, Regensburg, Germany.
authors: Juergen
authors: J
authors: Schlaier
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000473:pathology*; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*
keywords: Brain Gut Axis; Deep Brain Stimulation; Irritable Bowel Syndrome; Neuroplasticity
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