title: [Effect of "Xinjingjie mouthrinse" on prevention and treatment of radiation-induced oral mucositis].
abstract: OBJECTIVE
  To investigate the effect of "Xinjingjie compound lysostaphin antibacterial collutorium" on prevention and treatment of radiation-induced oral mucositis in a prospective, randomized and double-blind clinical trial.
  
  
  METHODS
  Sixty patients with oral cancer to be treated with radiotherapy were randomized into the experimental and control group. The experimental group (30 patients) was treated with "Xinjingjie mouthrinse" during the full course of radiotherapy, 4 times daily with 5 mL and 5 min each time. The control group (30 patients) rinsed the mouth in the same way with normal saline. Oral mucositis was assessed according to the RTOG criteria. The severity of mucositis and the degree of pain were recorded and photographed. Patients shouldn't be treated with other drugs until the level of oral mucositis reached above grade III. The results were statistically analyzed using Stata 12.0 software packages.
  
  
  RESULTS
  Age, gender, radiotherapy techniques and dose showed no significant difference between the 2 groups (P>0.05). The first onset of oral mucositis in the experimental group was later than that in the control group (11.0 times:9.1 times,P<0.05), and the incidence of pain at the early time of radiotherapy was lower (36.7%: 70.0%, P<0.05). Also, the onset time of grade III oral mucositis in the emperimental group was later than that in the control group (18.9 times:15.9 times,P<0.05), and the incidence of grade III oral mucositis in the experimental group was lower (63.3% vs. 90.0%, P<0.05).
  
  
  CONCLUSIONS
  "Xinjingjie mouthrinse" is worthwhile to be used in clinic because it can delay the occurrence time of radiation-induced oral mucositis, alleviate pain and reduce the indication of grade III oral mucositis.
authors: Department of Oromaxillofacial Head and Neck Oncology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China.E-mail:xuxuanli08@gmail.com.
authors: Xuan-li
authors: XL
authors: Xu
authors: Chen
authors: C
authors: Ye
authors: Lin
authors: L
authors: Zhang
authors: Rong-rong
authors: RR
authors: Li
authors: Zi-yang
authors: ZY
authors: Shao
authors: Wen-yong
authors: WY
authors: Tu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms; D009067:Mouthwashes; D011446:Prospective Studies; D011832:Radiation Injuries; D013280:Stomatitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D009067:Mouthwashes