title: Near Full-Length Characterization and Population Dynamics of the Human Immunodeficiency Virus Type I Circulating Recombinant Form 42 (CRF42_BF) in Luxembourg.
abstract: A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42_BF was identified in Luxembourg. We confirmed the inedited nature of CRF42_BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42_BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42_BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42_BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.
authors: 1 Laboratory of Retrovirology, Department of Infection and Immunity, Luxembourg Institute of Health , Luxembourg, Luxembourg .
authors: Daniel
authors: D
authors: Struck
authors: François
authors: F
authors: Roman
authors: Sébastien
authors: S
authors: De Landtsheer
authors: Jean-Yves
authors: JY
authors: Servais
authors: Christine
authors: C
authors: Lambert
authors: Cécile
authors: C
authors: Masquelier
authors: Véronique
authors: V
authors: Venard
authors: Jean
authors: J
authors: Ruelle
authors: Monique
authors: M
authors: Nijhuis
authors: Jean-Claude
authors: JC
authors: Schmit
authors: Carole
authors: C
authors: Seguin-Devaux
mesh_terms: D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008189:Luxembourg / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014779:Virus Replication
chemical_list: D012367:RNA, Viral