title: MicroRNA regulation and therapeutic targeting of survivin in cancer.
abstract: Survivin, the smallest member of IAP (inhibitor of apoptosis) family, is a dual functional protein acting as a critical apoptosis inhibitor and key cell cycle regulator. Survivin is usually expressed in embryonic tissues during development and undetectable in most terminally differentiated tissues. Numerous studies demonstrate that survivin is selectively upregulated in almost all types of human malignancies and its overexpression positively correlates with poor prognosis, tumor recurrence, and therapeutic resistance. This differential expression of survivin in tumors and normal tissues draws a great interest to develop survivin-targeted therapy for cancer treatment. Nonetheless, the molecular mechanisms controlling survivin expression in malignant tumor cells have not been fully understood. While aberrant activation of receptor tyrosine kinases (RTKs) and the downstream signaling, such as PI-3K/Akt, MEK/MAPK, mTOR, and STAT pathways, have frequently been shown to upregulate survivin, recent data suggest that a class of noncoding RNAs, microRNAs (miRNAs) also play an important role in survivin dysregulation in human cancers. Here, we focus on survivin expression-regulated by specific miRNAs binding to the 3'-UTR of survivin mRNA, and summarize the latest advances on survivin-targeted therapy in clinical trials and the therapeutic potential of survivin-targeting miRNAs in cancer.
authors: Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA ; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin, China.
authors: Jingcao
authors: J
authors: Huang
authors: Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA.
authors: Hui
authors: H
authors: Lyu
authors: State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin, China.
authors: Jianxiang
authors: J
authors: Wang
authors: Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA.
authors: Bolin
authors: B
authors: Liu
keywords: Survivin; cancer; miRNA; targeted therapy
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