title: Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007-2012).
abstract: Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007-2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44-9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level.
authors: Red de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, CIBERESP, Madrid, Spain. Electronic address: smonge@isciii.es.
authors: S
authors: S
authors: Monge
authors: Área de Vigilancia Epidemiológica del VIH/sida y Comportamientos de Riesgo, Plan Nacional sobre el Sida, Ministerio de Sanidad, Servicios Sociales e Igualdad/Centro Nacional de Epidemiología, Instituto de Salud Carlos III, CIBERESP, Madrid, Spain.
authors: M
authors: M
authors: Díez
authors: Instituto de Investigación Biosanitaria ibs GRANADA, Hospitales Universitarios de Granada, Spain.
authors: M
authors: M
authors: Alvarez
authors: Instituto de Investigación Biosanitaria ibs GRANADA, Hospitales Universitarios de Granada, Spain.
authors: V
authors: V
authors: Guillot
authors: Hospital Universitario Donostia, San Sebastián, Spain.
authors: J A
authors: JA
authors: Iribarren
authors: Hospital Universitario Virgen de la Victoria, Malaga, Spain.
authors: R
authors: R
authors: Palacios
authors: Hospital Universitario 12 de Octubre, Madrid, Spain.
authors: R
authors: R
authors: Delgado
authors: Hospital Universitario Mutua de Terrassa, Barcelona, Spain.
authors: A
authors: A
authors: Jaén
authors: Hospital San Pedro-CIBIR, Logroño, Spain.
authors: J R
authors: JR
authors: Blanco
authors: Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors: P
authors: P
authors: Domingo
authors: Hospital General Universitario de Alicante, Alicante, Spain.
authors: J
authors: J
authors: Portilla
authors: Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
authors: M J
authors: MJ
authors: Pérez Elías
authors: Instituto de Investigación Biosanitaria ibs GRANADA, Hospitales Universitarios de Granada, Spain.
authors: F
authors: F
authors: Garcia
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Antiretroviral agents; cohort studies; drug resistance; epidemiological monitoring; human immunodeficiency virus