title: Diffusion and Monod kinetics model to determine in vivo human corneal oxygen-consumption rate during soft contact lens wear.
abstract: OBJECTIVE
  We present an analysis of the corneal oxygen consumption Qc from non-linear models, using data of oxygen partial pressure or tension (P(O2) ) obtained from in vivo estimation previously reported by other authors. (1) METHODS: Assuming that the cornea is a single homogeneous layer, the oxygen permeability through the cornea will be the same regardless of the type of lens that is available on it. The obtention of the real value of the maximum oxygen consumption rate Qc,max is very important because this parameter is directly related with the gradient pressure profile into the cornea and moreover, the real corneal oxygen consumption is influenced by both anterior and posterior oxygen fluxes.
  
  
  RESULTS
  Our calculations give different values for the maximum oxygen consumption rate Qc,max, when different oxygen pressure values (high and low P(O2)) are considered at the interface cornea-tears film.
  
  
  CONCLUSIONS
  Present results are relevant for the calculation on the partial pressure of oxygen, available at different depths into the corneal tissue behind contact lenses of different oxygen transmissibility.
authors: Departamento de Polímeros, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Apartado Postal 70-360, Coyoacán, México, DF 04510, Mexico.
authors: Luis F
authors: LF
authors: Del Castillo
authors: Clinical & Experimental Optometry Research Lab, Center of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal.
authors: Ana R Ferreira
authors: AR
authors: da Silva
authors: Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, Apdo. Postal 55-534, 09340 México, DF, Mexico.
authors: Saul I
authors: SI
authors: Hernández
authors: Departamento de Física Aplicada, Universitat Jaume I, 12080 Castellón, Spain.
authors: M
authors: M
authors: Aguilella
authors: Departamento de Física Aplicada, Universitat Jaume I, 12080 Castellón, Spain.
authors: Andreu
authors: A
authors: Andrio
authors: Departamento de Termodinámica Aplicada, Escuela Técnica Superior de Ingenieros Industriales (ETSII), Universidad Politécnica de Valencia, Campus de Vera s/n, 46020 Valencia, Spain.
authors: Sergio
authors: S
authors: Mollá
authors: Departamento de Termodinámica Aplicada, Escuela Técnica Superior de Ingenieros Industriales (ETSII), Universidad Politécnica de Valencia, Campus de Vera s/n, 46020 Valencia, Spain. Electronic address: vicommo@ter.upv.es.
authors: Vicente
authors: V
authors: Compañ
mesh_terms: D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010101:Oxygen Consumption
keywords: Consumo de oxígeno de la córnea; Corneal oxygen consumption; Corneal oxygen permeability; Corneal oxygen pressure; Monod kinetics model; modelo cinético de Monod; permeabilidad al oxígeno de la córnea; presión del oxígeno en la córnea
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