title: Glycosphingolipids and cell death: one aim, many ways.
abstract: Glycosphingolipids (GSLs) are a family of bioactive lipids that in addition to their role in the regulation of structural properties of membrane bilayers have emerged as crucial players in many biological processes and signal transduction pathways. Rather than being uniformly distributed within membrane bilayers, GSLs are localized in selective domains called lipid rafts where many signaling platforms operate. One of the most important functions of GSLs, particularly ceramide, is their ability to regulate cell death pathways and hence cell fate. This complex role is accomplished by the ability of GSLs to act in distinct subcellular strategic centers, such as mitochondria, endoplasmic reticulum (ER) or lysosomes to mediate apoptosis, ER stress, autophagy, lysosomal membrane permeabilization and necroptosis. Hence better understanding the role of GSLs in cell death may be of relevance for a number of pathological processes and diseases, including neurodegeneration, metabolic liver diseases and cancer.
authors: Department of Cell Death and Proliferation, Instituto Investigaciones Biomedicas de Barcelona, CSIC, Barcelona, Spain.
authors: Carmen
authors: C
authors: Garcia-Ruiz
authors: Albert
authors: A
authors: Morales
authors: José C
authors: JC
authors: Fernández-Checa
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D059865:Endoplasmic Reticulum Stress; D006028:Glycosphingolipids / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism
chemical_list: D006028:Glycosphingolipids; D013108:Sphingomyelin Phosphodiesterase
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