title: Effects of Electroacupuncture Stimulation at "Zusanli" Acupoint on Hepatic NO Release and Blood Perfusion in Mice.
abstract: The study is to observe the influence of electroacupuncture (EA) stimulation at "Zusanli" (ST36) on the release of nitric oxide (NO) and blood perfusion (BP) in the liver and further explore whether the hepatic blood perfusion (HBP) changes were regulated by EA ST36 induced NO in nitric oxide synthase inhibited mice. The HBP change of the mice was detected by laser speckle perfusion imaging (LSPI) before and after being given interventions, and the NO in liver tissue was detected by nitric acid reductase in each group. The NO levels and HBP in the L-NAME group were significantly lower than those in the control group (P < 0.01). The NO level and HBP increase in EA group were significantly higher than those in control group (P < 0.05). The NO level in the L-NAME EA group was slightly higher than that in the L-NAME group. The HBP increase in the L-NAME EA group was not statistically significant. These results showed that EA could accelerate the synthesis of NO and thereby increase HBP via vasodilation in liver tissue.
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Shu-You
authors: SY
authors: Wang
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Dong
authors: D
authors: Zhang
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Li-Mei
authors: LM
authors: Tang
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Shun-Yue
authors: SY
authors: Li
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Mei
authors: M
authors: Wen
authors: Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Xiao-Jing
authors: XJ
authors: Song
references: Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G435-41
references: 22421619
references: Evid Based Complement Alternat Med. 2013;2013:670858
references: 24371465
references: World J Gastroenterol. 2010 Dec 28;16(48):6046-57
references: 21182219
references: Pharmacol Ther. 2013 Dec;140(3):239-57
references: 23859953
references: J Anat. 1966 Jul;100(Pt 3):651-63
references: 5965447
references: J Altern Complement Med. 2003 Apr;9(2):207-15
references: 12804074
references: PLoS One. 2014 May 22;9(5):e98486
references: 24853093
references: Abdom Imaging. 2011 Jun;36(3):273-81
references: 21267563
references: Trends Biochem Sci. 1997 Dec;22(12):477-81
references: 9433128
references: N Engl J Med. 1993 Dec 30;329(27):2002-12
references: 7504210
references: J Altern Complement Med. 2014 Jul;20(7):535-44
references: 24915606
references: Zhen Ci Yan Jiu. 2011 Dec;36(6):419-22
references: 22379787
references: Arch Biochem Biophys. 1997 May 1;341(1):186-92
references: 9143368
references: Free Radic Biol Med. 1998 Sep;25(4-5):434-56
references: 9741580
references: Circ J. 2014;78(8):1980-8
references: 24859498
references: Curr Hypertens Rep. 2014 Aug;16(8):463
references: 24924994
references: World J Gastroenterol. 2009 Jul 28;15(28):3532-7
references: 19630110
references: Mol Pharmacol. 2000 Nov;58(5):1026-34
references: 11040050
references: Biomed Res Int. 2013;2013:813174
references: 23865067
references: Menopause. 2010 Sep-Oct;17(5):978-82
references: 20505548
references: J Tradit Chin Med. 2013 Oct;33(5):592-6
references: 24660580
references: Evid Based Complement Alternat Med. 2011;2011:969231
references: 19531626
references: J Tradit Chin Med. 2012 Jun;32(2):238-42
references: 22876450
references: Microcirculation. 2006 Oct-Nov;13(7):577-85
references: 16990216
references: J Altern Complement Med. 2012 Oct;18(10):965-70
references: 22873117
references: Trials. 2014 Jun 12;15:224
references: 24925094
references: Nephrology (Carlton). 2014 Sep;19(9):562-7
references: 24839907
references: Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
references: 21890489
references: Bull Exp Biol Med. 2014 May;157(1):22-4
references: 24906962
references: Chest. 2004 Jun;125(6):2260-7
references: 15189950
references: J Altern Complement Med. 2012 Aug;18(8):777-83
references: 22888768
references: J Hepatol. 2014 Oct;61(4):912-24
references: 24911462
references: Evid Based Complement Alternat Med. 2012;2012:604590
references: 23258991
references: Circ Res. 2014 Aug 15;115(5):525-32
references: 24920698
references: J Infus Nurs. 2014 Mar-Apr;37(2):82-6
references: 24583937
references: Circulation. 1995 Aug 1;92(3):320-6
references: 7634444