title: [Influence of genetic polymorphisms (IL-10/CXCL8/CXCR2/NFκB) on the susceptibility of autoimmune rheumatic diseases].
abstract: The autoimmune rheumatologic disorders mostly have a common genetic path to the autoimmunity. Several genes have been associated with rheumatologic disorders; therefore, we are analyzing just the ones in those containing several evidences of the existence of association with the risk or protection from autoimmune disorder. The nuclear factor kappa beta (NF-kappa B), which regulates the autoimmune and anti-inflammatory responses, is associated with systemic sclerosis (SS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), just as the CXCR2 e CXCL8 genes. On the other hand, the interleukin-10 (IL-10), which is an anti-inflammatory cytokine, is associated with almost all rheumatologic disorders. In this article, we are reviewing the potential roles of these genes in the immune system and in several rheumatologic disorders. In relation to IL-10, several studies have been carried out, but most of them are controversial - some detected the absence of association, and others found association in different genetic polymorphisms. Conversely, in relation to NF-kappa B, it was studied just in RA and SLE, and no relevant significant analyses were observed. The genetic polymorphisms of the CXCR2 gene were associated with SS, but not with RA e SLE. On the other side, the genetic polymorphisms of the CXCL8 gene are not associated with SS, but with RA.
authors: Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors: Patricia Hartstein
authors: PH
authors: Salim
authors: Serviço de Reumatologia do Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. Electronic address: rmaxavier@hcpa.ufrgs.br.
authors: Ricardo Machado
authors: RM
authors: Xavier
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics; D011110:Polymorphism, Genetic; D023063:Receptors, Interleukin-8B / Q000235:genetics; D012216:Rheumatic Diseases / Q000235:genetics* / Q000276:immunology
chemical_list: C508606:CXCL8 protein, human; C508609:IL10 protein, human; D016209:Interleukin-8; D016328:NF-kappa B; D023063:Receptors, Interleukin-8B; D016753:Interleukin-10
keywords: Chemokine; Citocinas; Cytokine; Doenças reumatológicas; NF‐kB; Quimiocinas; Rheumatologic diseases