title: Tyrosine phosphorylation of WW proteins.
abstract: A number of key regulatory proteins contain one or two copies of the WW domain known to mediate protein-protein interaction via proline-rich motifs, such as PPxY. The Hippo pathway components take advantage of this module to transduce tumor suppressor signaling. It is becoming evident that tyrosine phosphorylation is a critical regulator of the WW proteins. Here, we review the current knowledge on the involved tyrosine kinases and their roles in regulating the WW proteins.
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Nina
authors: N
authors: Reuven
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Matan
authors: M
authors: Shanzer
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel yosef.shaul@weizmann.ac.il.
authors: Yosef
authors: Y
authors: Shaul
mesh_terms: D006801:Humans; D010088:Oxidoreductases / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding / Q000502:physiology; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*; D000074584:WW Domain-Containing Oxidoreductase
chemical_list: D025521:Tumor Suppressor Proteins; D014443:Tyrosine; D010088:Oxidoreductases; D000074584:WW Domain-Containing Oxidoreductase; C486071:WWOX protein, human; D011505:Protein-Tyrosine Kinases
keywords: Hippo pathway; cell fate decision-making; non-receptor tyrosine kinases; protein tyrosine phosphorylation; protein–protein interaction
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