title: Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension.
abstract: OBJECTIVE
  To investigate the impact of age on arterial stiffness and blood pressure (BP) variables in newly diagnosed untreated hypertension (HT).
  
  
  METHODS
  A total of 144 patients with newly diagnosed untreated HT were divided into two groups: young group (age ≤50 years, n=71), and old group (age >50 years, n=73). BP variables were measured on office or 24 hours ambulatory BP monitoring (ABPM). Parameters of arterial stiffness were measured on pulse wave velocity (PWV). Pulse wave analysis (PWA) was compared.
  
  
  RESULTS
  Although office BP and pulse pressure (PP) were significantly (p<0.05) higher in the young group than in the old group, BP and PP on ABPM were not significantly different. Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group. Age showed significant positive correlation with both PWV and PWA variables in the young group with HT. However, age only showed significant positive correlation with PWV in the old group with HT. In the young group with HT, PWA variable showed better correlation with age than PWV.
  
  
  CONCLUSIONS
  Considering BP levels on ABPM, office BP is prone to be overestimated in young patients with HT. Parameters of arterial stiffness measured by PWV and PWA were more affected by age rather than by BP level in patients with HT. Therefore, PWA variable might be a more sensitive marker of arterial stiffness in young patients with HT. However, PWV might be a better marker for old patients with HT.
authors: Department of Internal Medicine, Christian Hospital, Gwangju, Korea.
authors: Soo Kyung
authors: SK
authors: Cho
authors: Department of Internal Medicine, Christian Hospital, Gwangju, Korea.
authors: Sang Ki
authors: SK
authors: Cho
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Kye Hun
authors: KH
authors: Kim
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Jae Yeong
authors: JY
authors: Cho
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Hyun Ju
authors: HJ
authors: Yoon
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Nam Sik
authors: NS
authors: Yoon
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Young Joon
authors: YJ
authors: Hong
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Hyung Wook
authors: HW
authors: Park
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Ju Han
authors: JH
authors: Kim
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Youngkeun
authors: Y
authors: Ahn
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Myung Ho
authors: MH
authors: Jeong
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Jeong Gwan
authors: JG
authors: Cho
authors: Department of Cardiology, Translational Research Center on Aging, Chonnam National University Hospital, Gwangju, Korea.
authors: Jong Chun
authors: JC
authors: Park
keywords: Aging; Hypertension; Vascular stiffness
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