title: Variability of single trial brain activation predicts fluctuations in reaction time.
abstract: Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power). We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors. Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype. We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability.
authors: Department of Child and Adolescent Psychiatry, Goethe University Frankfurt, Deutschordenstraße 50, D-60528 Frankfurt/Main, Germany; Child and Adolescent Psychiatry, University of Cologne, Germany. Electronic address: Stephan.Bender@kgu.de.
authors: Stephan
authors: S
authors: Bender
authors: Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim/Heidelberg University, J5, D-68159 Mannheim, Germany; University of Freiburg, Department of Child and Adolescent Psychiatry, Freiburg, Germany.
authors: Tobias
authors: T
authors: Banaschewski
authors: Section for Clinical Neurophysiology and Multimodal Neuroimaging, Child and Adolescent Psychiatric Department, University of Technology, Fetscherstraße 74, D-01307 Dresden, Germany; University of Freiburg, Department of Child and Adolescent Psychiatry, Freiburg, Germany.
authors: Veit
authors: V
authors: Roessner
authors: University of Bangor, School of Psychology, Bangor, Wales, UK; University of Freiburg, Department of Child and Adolescent Psychiatry, Freiburg, Germany.
authors: Christoph
authors: C
authors: Klein
authors: Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, D-68159 Mannheim, Germany.
authors: Marcella
authors: M
authors: Rietschel
authors: Neurology Department, University Hospital Freiburg, Germany; University of Freiburg, Department of Child and Adolescent Psychiatry, Freiburg, Germany.
authors: Bernd
authors: B
authors: Feige
authors: Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim/Heidelberg University, J5, D-68159 Mannheim, Germany; Department of Child and Adolescent Psychiatry, University of Zürich, Switzerland; University of Freiburg, Department of Child and Adolescent Psychiatry, Freiburg, Germany.
authors: Daniel
authors: D
authors: Brandeis
authors: Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim/Heidelberg University, J5, D-68159 Mannheim, Germany; Department of Psychology, University of Potsdam, Germany.
authors: Manfred
authors: M
authors: Laucht
mesh_terms: D000293:Adolescent; D001921:Brain / Q000502:physiology*; D015331:Cohort Studies; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011930:Reaction Time / Q000502:physiology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012931:Social Environment; D012959:Socioeconomic Factors
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins
keywords: Event-related potential; Haplotype; Intertrial coherence; Low frequency amplitude variability; Psychosocial stress; Topographic consistency