title: Feasibility of image-guided radiotherapy and concurrent chemotherapy for locally advanced nonsmall cell lung cancer.
abstract: A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.
authors: Department of Radiation Oncology, Howard University , Washington, DC ,1.
authors: Nam P
authors: NP
authors: Nguyen
authors: Sarah
authors: S
authors: Kratz
authors: Alexander
authors: A
authors: Chi
authors: Jacqueline
authors: J
authors: Vock
authors: Paul
authors: P
authors: Vos
authors: Wei
authors: W
authors: Shen
authors: Vinh-Hung
authors: VH
authors: Vincent
authors: Lars
authors: L
authors: Ewell
authors: Siyoung
authors: S
authors: Jang
authors: Gabor
authors: G
authors: Altdorfer
authors: Ulf
authors: U
authors: Karlsson
authors: Juan
authors: J
authors: Godinez
authors: William
authors: W
authors: Woods
authors: Suresh
authors: S
authors: Dutta
authors: Fred
authors: F
authors: Ampil
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D061089:Radiotherapy, Image-Guided / Q000379:methods; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Chemoradiation; IGRT; Locally advanced; NSCLC