title: Dextrin and poly(acrylic acid)-based biodegradable, non-cytotoxic, chemically cross-linked hydrogel for sustained release of ornidazole and ciprofloxacin.
abstract: Herein, novel biodegradable, stimulus-responsive, chemically cross-linked and porous hydrogel has been synthesized to evaluate its applicability as an efficient carrier for sustained release of ornidazole and ciprofloxacin. The cross-linked hydrogel (c-Dxt/pAA) has been developed from dextrin and poly(acrylic acid) using N,N'-methylene bis(acrylamide) cross-linker via Michael-type addition reaction. With the variation of reaction parameters, various c-Dxt/pAA hydrogels have been synthesized to optimize the best one. c-Dxt/pAA hydrogel has been characterized using various physicochemical characterization techniques. The hydrogel demonstrates significant pH and temperature sensitivity. Gel characteristics and gel kinetics have been performed through the measurement of rheological parameters. The hydrogel shows noncytotoxic behavior toward human mesenchymal stem cells. Biodegradation study predicts that c-Dxt/pAA is degradable in nature. The in vitro release of ornidazole and ciprofloxacin suggests that the hydrogel released both the drugs in a controlled manner with extensive stability up to 3 months. The results suggest that c-Dxt/pAA is probably a promising candidate for controlled release of ornidazole and ciprofloxacin.
authors: Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines , Dhanbad 826004, India.
authors: Dipankar
authors: D
authors: Das
authors: Paulomi
authors: P
authors: Ghosh
authors: Santanu
authors: S
authors: Dhara
authors: Asit Baran
authors: AB
authors: Panda
authors: Sagar
authors: S
authors: Pal
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002939:Ciprofloxacin / Q000737:chemistry* / Q000378:metabolism; D003912:Dextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009113:Muramidase / Q000378:metabolism; D009950:Ornidazole / Q000737:chemistry* / Q000378:metabolism; D012212:Rheology; D013607:Tablets / Q000737:chemistry; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D003912:Dextrins; D004337:Drug Carriers; D020100:Hydrogels; D013607:Tablets; C006903:carbopol 940; D002939:Ciprofloxacin; D009950:Ornidazole; D009113:Muramidase
keywords: biodegradable; dextrin; drug delivery; hydrogel; poly(acrylic acid)