title: TPH, SLC6A2, SLC6A3, DRD2 and DRD4 Polymorphisms and Neuroendocrine Factors Predict SSRIs Treatment Outcome in the Chinese Population with Major Depression.
abstract: OBJECTIVE
  This study was intended to determine whether antidepressant outcome to SSRIs was associated with catecholamine gene polymorphisms and neuroendocrine factors in patients of Chinese Han ethnicity with MDD.
  
  
  METHODS
  A total of 290 MDD patients were recruited and received a 6-week randomized double-blinded treatment. Cortisol, adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), 3'-triiodothyronine (T3), thyroxine (T4), free triiodothyronine (fT3), and free thyroxine (fT4) levels were measured at the baseline. Allele, genotype, and haplotype frequencies of catecholamine genes were compared between responders and non-responders, remission and non-remission groups respectively.
  
  
  RESULTS
  We found that genotype frequency of the rs1800544 polymorphism in the DRD4 gene was significantly different between responders and non-responders (P<0.05). Also the frequency of the rs1800544 CG genotype was significantly higher (P<0.05) in responders (51.4%) than that in non-responders (35.8%). No significant difference was found between responders and non-responders, remission and non-remission groups in the SNPs polymorphisms in the TPH, SLC6A2, SLC6A3, or DRD2 genes. The combination of all neuroendocrine factors, clinical characteristics and gene polymorphisms predicted 74.8% of the variation in SSRI response and 65.5% in SSRI remission.
  
  
  CONCLUSIONS
  Polymorphisms of the DRD4 gene were associated with SSRI response in Chinese Han MDD patients. A combination of clinical characteristics, neuroendocrine factors, and gene polymorphisms might be able to predict the outcome to SSRIs.
authors: Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors: L
authors: L
authors: Yin
authors: Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors: Y Y
authors: YY
authors: Zhang
authors: Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors: X
authors: X
authors: Zhang
authors: Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors: T
authors: T
authors: Yu
authors: Bio-X Institute, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors: G
authors: G
authors: He
authors: Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
authors: X L
authors: XL
authors: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D002681:China; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D004311:Double-Blind Method; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000187:drug effects*; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014365:Tryptophan Hydroxylase / Q000235:genetics; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D017367:Selective Serotonin Reuptake Inhibitors; D014365:Tryptophan Hydroxylase; C581293:DRD2 protein, human; C493599:DRD4 protein, human; C493227:SLC6A2 protein, human; C493214:SLC6A3 protein, human