title: Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension.
abstract: During dynamic exercise, muscle metaboreflex activation (MMA; induced via partial hindlimb ischemia) markedly increases mean arterial pressure (MAP), and MAP is sustained when the ischemia is maintained following the cessation of exercise (postexercise muscle ischemia, PEMI). We previously reported that the sustained pressor response during PEMI in normal individuals is driven by a sustained increase in cardiac output (CO) with no peripheral vasoconstriction. However, we have recently shown that the rise in CO with MMA is significantly blunted in hypertension (HTN). The mechanisms sustaining the pressor response during PEMI in HTN are unknown. In six chronically instrumented canines, hemodynamic responses were observed during rest, mild exercise (3.2 km/h), MMA, and PEMI in the same animals before and after the induction of HTN [Goldblatt two kidney, one clip (2K1C)]. In controls, MAP, CO and HR increased with MMA (+52 ± 6 mmHg, +2.1 ± 0.3 l/min, and +37 ± 7 beats per minute). After induction of HTN, MAP at rest increased from 97 ± 3 to 130 ± 4 mmHg, and the metaboreflex responses were markedly attenuated (+32 ± 5 mmHg, +0.6 ± 0.2 l/min, and +11 ± 3 bpm). During PEMI in HTN, HR and CO were not sustained, and MAP fell to normal recovery levels. We conclude that the attenuated metaboreflex-induced HR, CO, and MAP responses are not sustained during PEMI in HTN.
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Marty D
authors: MD
authors: Spranger
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Jasdeep
authors: J
authors: Kaur
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Javier A
authors: JA
authors: Sala-Mercado
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Tiago M
authors: TM
authors: Machado
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Abhinav C
authors: AC
authors: Krishnan
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
authors: Alberto
authors: A
authors: Alvarez
authors: Department of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan doleary@med.wayne.edu.
authors: Donal S
authors: DS
authors: O'Leary
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D062186:Arterial Pressure; D002302:Cardiac Output; D002628:Chemoreceptor Cells / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D004734:Energy Metabolism; D005260:Female; D006339:Heart Rate; D006614:Hindlimb; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000503:physiopathology*; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000294:innervation* / Q000378:metabolism; D005082:Physical Exertion; D012018:Reflex; D013997:Time Factors; D014661:Vasoconstriction
keywords: exercise pressor reflex; hypertension; peripheral resistance; postexercise circulatory occlusion
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