title: Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood.
abstract: Cord blood transplantation, an alternative to traditional stem cell transplants (bone marrow or peripheral blood stem cell transplantation), is an attractive option for patients lacking suitable stem cell transplant donors. Cord blood units have also proven to be a valuable donor source for the development of cellular therapeutics. Virus-specific T cells and regulatory T cells are two cord blood-derived products that have shown promise in early-phase clinical trials to prevent and/or treat viral infections and graft-versus-host disease, respectively. We describe how current strategies that use cord blood-derived regulatory T cells and virus-specific T cells have been developed to improve outcomes for cord blood transplant recipients.
authors: Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center and The George Washington University, Washington, DC, USA; Center for Cancer and Immunology Research, Children's National Medical Center and The George Washington University, Washington, DC, USA; Division of Blood and Marrow Transplantation, Children's National Medical Center and The George Washington University, Washington, DC, USA; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center and The George Washington University, Washington, DC, USA. Electronic address: PHanley@childrensnational.org.
authors: Patrick J
authors: PJ
authors: Hanley
authors: Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center and The George Washington University, Washington, DC, USA; Center for Cancer and Immunology Research, Children's National Medical Center and The George Washington University, Washington, DC, USA; Division of Blood and Marrow Transplantation, Children's National Medical Center and The George Washington University, Washington, DC, USA; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center and The George Washington University, Washington, DC, USA.
authors: Catherine M
authors: CM
authors: Bollard
authors: Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: Bruns072@umn.edu.
authors: Claudio G
authors: CG
authors: Brunstein
mesh_terms: D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D013045:Species Specificity; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014780:Viruses / Q000276:immunology*
keywords: antiviral; cell therapy; cord blood; graft-versus-host disease; immunotherapy; regulatory T cells (Treg); transplant
references: Viruses. 2014 Jun;6(6):2242-58
references: 24872114
references: Blood. 2007 Jan 15;109(2):827-35
references: 17003369
references: Br J Haematol. 2011 Jul;154(1):150-3
references: 21501134
references: J Immunol. 2007 Feb 15;178(4):2221-8
references: 17277127
references: Sci Transl Med. 2011 May 18;3(83):83ra41
references: 21593401
references: Front Immunol. 2012 Jul 31;3:211
references: 23060872
references: J Immunol. 2002 Jan 15;168(2):909-18
references: 11777989
references: Blood. 2009 Aug 27;114(9):1958-67
references: 19443656
references: Blood Cells Mol Dis. 2008 Jan-Feb;40(1):63-7
references: 17869548
references: Biol Blood Marrow Transplant. 2013 Aug;19(8):1271-3
references: 23806771
references: Cytotherapy. 2010 Oct;12(6):713-20
references: 20818913
references: J Exp Med. 2001 Jun 4;193(11):1311-8
references: 11390438
references: Am J Reprod Immunol. 2010 Jun;63(6):445-59
references: 20331584
references: Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11445-50
references: 11016962
references: Cytotherapy. 2006;8(2):149-57
references: 16698688
references: Cytotherapy. 2011 Sep;13(8):976-86
references: 21539497
references: Blood. 2005 Jan 1;105(1):274-81
references: 15353478
references: Blood. 2010 Dec 2;116(23):5045-9
references: 20826724
references: Sci Transl Med. 2014 Jun 25;6(242):242ra83
references: 24964991
references: Cytotherapy. 2014 Nov;16(11):1528-36
references: 25231890
references: Blood. 2011 Jan 20;117(3):1061-70
references: 20952687
references: J Vis Exp. 2012;(63):e3627
references: 22588077
references: Blood. 2006 Sep 1;108(5):1770-3
references: 16675712
references: Blood. 2002 May 15;99(10):3493-9
references: 11986199
references: Biol Blood Marrow Transplant. 2008 Oct;14(10):1190-6
references: 18804050
references: J Exp Med. 2005 Aug 1;202(3):379-86
references: 16061727
references: Blood. 2005 Jan 15;105(2):750-8
references: 15374887
references: Haematologica. 2011 Aug;96(8):1204-12
references: 21546501
references: Science. 1992 Jul 10;257(5067):238-41
references: 1352912
references: J Exp Med. 2002 Aug 5;196(3):389-99
references: 12163567
references: Front Immunol. 2014 Feb 11;5:46
references: 24575095
references: Inflammation. 2012 Dec;35(6):1773-80
references: 22752562
references: Blood. 2013 Oct 24;122(17):2965-73
references: 24030379
references: Methods Mol Biol. 2011;707:3-17
references: 21287325
references: Transfusion. 2014 Feb;54(2):353-63
references: 23772685
references: Clin Exp Immunol. 2002 Apr;128(1):118-23
references: 11982599
references: Cancer Immunol Immunother. 2010 Mar;59(3):473-7
references: 19908041
references: Am J Transplant. 2011 Jun;11(6):1148-57
references: 21564534
references: Blood. 2010 Apr 1;115(13):2695-703
references: 20110422
references: Cell Immunol. 1999 Aug 1;195(2):81-8
references: 10448007
references: Blood. 2008 Nov 15;112(10):3974-81
references: 18768783
references: Clin Infect Dis. 2011 Jan 1;52(1):49-57
references: 21148519
references: Blood. 2004 Dec 1;104(12):3804-12
references: 15292057
references: Biol Blood Marrow Transplant. 2010 Jul;16(7):994-1004
references: 20167279
references: Transpl Int. 2007 Jun;20(6):534-41
references: 17362475
references: Biol Blood Marrow Transplant. 2007 Jun;13(6):707-14
references: 17531781
references: J Immunol. 2011 Sep 1;187(5):2061-6
references: 21856944
references: Cancer Res. 2010 Jul 1;70(13):5249-58
references: 20530666
references: Transplantation. 2000 Nov 27;70(10):1507-15
references: 11118098
references: J Immunother. 2010 Apr;33(3):305-15
references: 20445351
references: Nat Med. 2006 Oct;12(10):1160-6
references: 16998485
references: Blood. 2008 Oct 1;112(7):2847-57
references: 18645038
references: Mol Ther. 2013 Nov;21(11):2113-21
references: 23783429
references: J Immunol. 2001 Feb 1;166(3):2141-6
references: 11160266
references: Blood. 2011 Apr 7;117(14):3921-8
references: 21292771
references: Biol Blood Marrow Transplant. 2008 Nov;14(11):1245-52
references: 18940679
references: J Exp Med. 2002 Aug 5;196(3):401-6
references: 12163568
references: Blood. 2013 Jun 27;121(26):5113-23
references: 23610374
references: Blood. 2015 Feb 26;125(9):1502-6
references: 25428215
references: Mol Ther. 2012 Aug;20(8):1622-32
references: 22801446
references: J Clin Invest. 2003 Dec;112(11):1688-96
references: 14660744
references: Cytotherapy. 2014 Jan;16(1):90-100
references: 24480547
references: Clin Immunol. 2009 Apr;131(1):109-18
references: 19153062