title: No association between serum adenosine deaminase activity and disease activity in Crohn's disease.
abstract: BACKGROUND
  Adenosine deaminase activity is proposed as a marker of inflammation in some inflammatory conditions.
  
  
  OBJECTIVE
  To investigate the association of serum adenosine deaminase activity and disease activity in Crohn's disease patients.
  
  
  METHODS
  In a cross-sectional study, 30 consecutive known cases of Crohn's disease (15 with active disease and 15 in remission) referring to a university hospital in Tehran (Iran) and 15 age- and gender-matched healthy controls were studied. Disease activity was assessed using the Crohn's disease activity index (cutoff >150). Total serum adenosine deaminase activity, C-reactive protein, erythrocyte sedimentation rate, and fecal calprotectin were evaluated in patients. Serum adenosine deaminase activity was measured in controls.
  
  
  RESULTS
  Mean age of the patients was 36.8 ± 12.6 years, and 56.7 % were male. Serum adenosine deaminase activity in patients with active disease, patients in remission, and controls was 12.3 ± 5.9, 14.6 ± 6.2, and 11.9 ± 6.4 U/L, respectively (P = 0.458). Compared with patients in remission, those with active disease had higher erythrocyte sedimentation rate (40.4 ± 30.6 vs. 16.9 ± 16.0 mm/h, P = 0.014) and higher frequency of positive C-reactive protein (66.6 vs. 13.3 %, P = 0.004) and positive fecal calprotectin tests (86.6 vs. 33.3 %, P = 0.004). Serum adenosine deaminase activity was not correlated with erythrocyte sedimentation rate (r = 0.05, P = 0.761) and was not different between patients with positive and negative C-reactive protein (12.2 ± 5.4 vs. 14.2 ± 6.5 U/L, P = 0.393) and fecal calprotectin tests (11.7 ± 5.3 vs. 16.0 ± 6.5 U/L, P = 0.063).
  
  
  CONCLUSIONS
  In patients with Crohn's disease, serum adenosine deaminase activity is not associated with clinical disease activity or with other inflammation markers and cannot be suggested as an inflammation marker.
authors: Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran, mahmood.sajadi@gmail.com.
authors: Mahmoud
authors: M
authors: Sajjadi
authors: Ali
authors: A
authors: Gholamrezaei
authors: Nasser Ebrahimi
authors: NE
authors: Daryani
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003424:Crohn Disease / Q000201:enzymology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D008297:Male
chemical_list: D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein; D000243:Adenosine Deaminase
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