title: Cognitive profile of LRRK2-related Parkinson's disease.
abstract: BACKGROUND
  Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized.
  
  
  METHODS
  A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models.
  
  
  RESULTS
  LRRK2 mutation carriers (n = 29) demonstrated better performance on the Mini Mental State Examination (P = 0.03) and the Letter-Number Sequencing Test (P = 0.005). A smaller proportion of LRRK2 carriers were demented (P = 0.03).
  
  
  CONCLUSIONS
  Our cross-sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in LRRK2-related PD. Future longitudinal studies are needed to determine whether LRRK2 mutation carriers exhibit slower cognitive decline. © 2015 International Parkinson and Movement Disorder Society.
authors: Virginia Mason Neuroscience Institute, Seattle, Washington, USA.
authors: Sindhu
authors: S
authors: Srivatsal
authors: Brenna
authors: B
authors: Cholerton
authors: James B
authors: JB
authors: Leverenz
authors: Zbigniew K
authors: ZK
authors: Wszolek
authors: Ryan J
authors: RJ
authors: Uitti
authors: Dennis W
authors: DW
authors: Dickson
authors: Daniel
authors: D
authors: Weintraub
authors: John Q
authors: JQ
authors: Trojanowski
authors: Vivianna M
authors: VM
authors: Van Deerlin
authors: Joseph F
authors: JF
authors: Quinn
authors: Kathryn A
authors: KA
authors: Chung
authors: Amie L
authors: AL
authors: Peterson
authors: Stewart A
authors: SA
authors: Factor
authors: Cathy
authors: C
authors: Wood-Siverio
authors: Jennifer G
authors: JG
authors: Goldman
authors: Glenn T
authors: GT
authors: Stebbins
authors: Bryan
authors: B
authors: Bernard
authors: Beate
authors: B
authors: Ritz
authors: Rebecca
authors: R
authors: Rausch
authors: Alberto J
authors: AJ
authors: Espay
authors: Fredy J
authors: FJ
authors: Revilla
authors: Johnna
authors: J
authors: Devoto
authors: Liana S
authors: LS
authors: Rosenthal
authors: Ted M
authors: TM
authors: Dawson
authors: Marilyn S
authors: MS
authors: Albert
authors: Ignacio F
authors: IF
authors: Mata
authors: Shu-Ching
authors: SC
authors: Hu
authors: Kathleen S
authors: KS
authors: Montine
authors: Catherine
authors: C
authors: Johnson
authors: Thomas J
authors: TJ
authors: Montine
authors: Karen L
authors: KL
authors: Edwards
authors: Jing
authors: J
authors: Zhang
authors: Cyrus P
authors: CP
authors: Zabetian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000209:etiology* / Q000235:genetics; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases
keywords: LRRK2; Parkinson's disease; cognition; neuropsychological tests; working memory
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