title: [Efficacy of combination therapy with mirabegron for anticholinergic-resistant neurogenic bladder: videourodynamic evaluation].
abstract: Using a videourodynamic study, we examined the efficacy of combination therapy with mirabegron for anticholinergic-resistant neurogenic bladder. We retrospectively studied 7 patients with neurogenic bladder (5 males and 2 females) who had detrusor overactivity (DO) or low compliance bladder (＜10 ml/cmH2O) despite taking anticholinergic medication. Bladder deformity was categorized from G0 to G3 by Ogawa's classification. Mean age of study patients was 51 years (25-76). Underlying diseases were spinal cord injury in 3 patients, spina bifida in 2, spinal cord infarction in 1, and post-radical hysterectomy in 1. Preceding anticholinergic medication was solifenacin 5 mg in 1 patient, solifenacin 10 mg in 5, and tolterodine 4 mg in 1. Before mirabegron, bladder deformity was G1 in 4 patients, G2 in 1 and G3 in 2, and vesicoureteral reflux (VUR) was detected in 3 patients. Five and 4 patients had detrusor overactivity and low compliance bladder, respectively. Videourodynamic study was reevaluated at a mean of 7 months (2- 12 months) after mirabegron. After mirabegron, urinary incontinence was improved in all patients. G3 bladder deformity was improved to G2 and G1 in one patient each, and VUR disappeared in all 3 patients. DO disappeared in 2 of the 5 patients, and bladder compliance was improved in all 4 patients with low compliance bladder. In conclusion, combination therapy of mirabegron is effective and beneficial for anticholinergic-resistant neurogenic bladder.
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Naoki
authors: N
authors: Wada
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Satoshi
authors: S
authors: Okazaki
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Shin
authors: S
authors: Kobayashi
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Kazumi
authors: K
authors: Hashizume
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Masafumi
authors: M
authors: Kita
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Seiji
authors: S
authors: Matsumoto
authors: The Department of Renal and Urologic Surgery, Asahikawa Medical University.
authors: Hidehiro
authors: H
authors: Kakizaki
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D003952:Diagnostic Imaging; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013118:Spinal Cord Diseases / Q000150:complications; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D014563:Urodynamics
chemical_list: D000083:Acetanilides; D018680:Cholinergic Antagonists; D013844:Thiazoles; C520025:mirabegron