title: Wearable devices for blood purification: principles, miniaturization, and technical challenges.
abstract: The prevalences of end-stage renal disease (ESRD) and renal replacement therapy (RRT) continue to increase across the world imposing staggering costs on providers. Therefore, strategies to optimize the treatment and improve survival are of fundamental importance. Despite the benefits of daily dialysis, its implementation is difficult and wearable hemodialysis might represent an alternative by which frequent treatments can be delivered to ESRD patients with much less interference in their routines promoting better quality of life. The development of the wearable artificial kidney (WAK) requires incorporation of basic components of a dialysis system into a wearable device that allows mobility, miniaturization, and above all, patient-oriented management. The technical requirements necessary for WAK can be divided into the following broad categories: dialysis membranes, dialysis regeneration, vascular access, patient monitoring systems, and power sources. Pumping systems for blood and other fluids are the most critical components of the entire device.
authors: International Renal Research Institute, Vicenza, Italy.
authors: Paolo
authors: P
authors: Armignacco
authors: Anna
authors: A
authors: Lorenzin
authors: Mauro
authors: M
authors: Neri
authors: Federico
authors: F
authors: Nalesso
authors: Francesco
authors: F
authors: Garzotto
authors: Claudio
authors: C
authors: Ronco
mesh_terms: D004867:Equipment Design; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D007688:Kidneys, Artificial; D008904:Miniaturization / Q000295:instrumentation*; D018670:Monitoring, Ambulatory; D011788:Quality of Life; D017582:Renal Replacement Therapy / Q000295:instrumentation*