title: Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.
abstract: Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious and degenerative nervous system disorders. These, in whole or in part, are a significant societal burden due to growth in numbers of affected people and in disease severity. Lost productivity of the patient and his or her caregiver, and the emotional and financial burden cannot be overstated. The need for improved health care, treatment and diagnostics is immediate. A means to such an end is nanotechnology. Indeed, recent developments of health-care enabling nanotechnologies and nanomedicines range from biomarker discovery including neuroimaging to therapeutic applications for degenerative, inflammatory and infectious disorders of the nervous system. This review focuses on the current and future potential of the field to positively affect clinical outcomes. From the clinical editor: Many nervous system disorders remain unresolved clinical problems. In many cases, drug agents simply cannot cross the blood-brain barrier (BBB) into the nervous system. The advent of nanomedicines can enhance the delivery of biologically active molecules for targeted therapy and imaging. This review focused on the use of nanotechnology for degenerative, inflammatory, and infectious diseases in the nervous system.
authors: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: hegendel@unmc.edu.
authors: Howard E
authors: HE
authors: Gendelman
authors: Department of Biomedical Sciences, Iowa State University, Ames, IA USA.
authors: Vellareddy
authors: V
authors: Anantharam
authors: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Tatiana
authors: T
authors: Bronich
authors: Department of Biomedical Sciences, Iowa State University, Ames, IA USA.
authors: Shivani
authors: S
authors: Ghaisas
authors: Department of Biomedical Sciences, Iowa State University, Ames, IA USA.
authors: Huajun
authors: H
authors: Jin
authors: Department of Biomedical Sciences, Iowa State University, Ames, IA USA.
authors: Anumantha G
authors: AG
authors: Kanthasamy
authors: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Xinming
authors: X
authors: Liu
authors: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
authors: JoEllyn
authors: J
authors: McMillan
authors: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
authors: R Lee
authors: RL
authors: Mosley
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
authors: Balaji
authors: B
authors: Narasimhan
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA. Electronic address: suryakm@iastate.edu.
authors: Surya K
authors: SK
authors: Mallapragada
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000628:therapy*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*
keywords: Diagnostics; Drug development; Nanoneuromedicine; Nanotechnology; Neurodegenerative disorders
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