title: Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection.
abstract: We report a case of recurrent disseminated Mycobacterium avium complex (DMAC) disease with anti-gamma interferon autoantibodies. To our knowledge, this is the first reported case caused by reinfection with a separate isolate of M. avium. DMAC disease activity was monitored using serum IgG antibody titers against lipid antigens extracted from a MAC strain.
authors: Health Center, Keio University, Shinjuku, Tokyo, Japan.
authors: Tomoyasu
authors: T
authors: Nishimura
authors: Japan BCG Central Laboratory, Kiyose, Tokyo, Japan.
authors: Yukiko
authors: Y
authors: Fujita-Suzuki
authors: Isehara Kyodo Hospital, Isehara, Kanagawa, Japan.
authors: Makoto
authors: M
authors: Yonemaru
authors: Department of Microbiology, Tokyo Medical University, Shinjuku, Tokyo, Japan.
authors: Kiyofumi
authors: K
authors: Ohkusu
authors: Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
authors: Takuro
authors: T
authors: Sakagami
authors: Department of Microbiology and Physiologic Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
authors: Stephen M
authors: SM
authors: Carpenter
authors: Kameda Medical Center, Kamogawa, Chiba, Japan.
authors: Yoshihito
authors: Y
authors: Otsuka
authors: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
authors: Ho
authors: H
authors: Namkoong
authors: Japan BCG Central Laboratory, Kiyose, Tokyo, Japan.
authors: Ikuya
authors: I
authors: Yano
authors: Center of Infectious Diseases and Infection Control, Keio University School of Medicine, Shinjuku, Tokyo, Japan n-hasegawa@z8.keio.jp.
authors: Naoki
authors: N
authors: Hasegawa
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology* / Q000382:microbiology*
chemical_list: D001323:Autoantibodies; D007371:Interferon-gamma
references: Mol Microbiol. 2000 May;36(3):762-71
references: 10844663
references: J Infect Dis. 2004 Oct 1;190(7):1347-54
references: 15346348
references: Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
references: 17277290
references: J Infect Chemother. 2009 Apr;15(2):118-22
references: 19396523
references: J Clin Microbiol. 2009 Jul;47(7):2156-64
references: 19403768
references: Clin Infect Dis. 2009 Aug 15;49(4):529-35
references: 19591595
references: N Engl J Med. 2012 Aug 23;367(8):725-34
references: 22913682
references: J Infect Chemother. 2013 Dec;19(6):1152-7
references: 23456204
references: Ann Am Thorac Soc. 2014 Jan;11(1):45-53
references: 24251904
references: Chest. 2014 Aug;146(2):276-82
references: 24457542