title: Detecting tissue optical and mechanical properties with an ultrasound modulated optical imaging system in reflection detection geometry.
abstract: Tissue optical and mechanical properties are correlated to tissue pathologic changes. This manuscript describes a dual-mode ultrasound modulated optical imaging system capable of sensing local optical and mechanical properties in reflection geometry. The optical characterisation was achieved by the acoustic radiation force assisted ultrasound modulated optical tomography (ARF-UOT) with laser speckle contrast detection. Shear waves generated by the ARF were also tracked optically by the same system and the shear wave speed was used for the elasticity measurement. Tissue mimicking phantoms with multiple inclusions buried at 11 mm depth were experimentally scanned with the dual-mode system. The inclusions, with higher optical absorption and/or higher stiffness than background, were identified based on the dual results and their stiffnesses were quantified. The system characterises both optical and mechanical properties of the inclusions compared with the ARF-UOT or the elasticity measurement alone. Moreover, by detecting the backward scattered light in reflection detection geometry, the system is more suitable for clinical applications compared with transmission geometry.
authors: Imperial College London, Department of Bioengineering, London, SW7 2AZ, UK.
authors: Yi
authors: Y
authors: Cheng
authors: Imperial College London, Department of Bioengineering, London, SW7 2AZ, UK.
authors: Sinan
authors: S
authors: Li
authors: King's College London, Department of Biomedical Engineering, London, SE1 7EH, UK.
authors: Robert J
authors: RJ
authors: Eckersley
authors: Imperial College London, Hamlyn Centre for Robotic Surgery, Department of Surgery and Cancer, London, SW7 2AZ, UK.
authors: Daniel S
authors: DS
authors: Elson
authors: Imperial College London, Department of Bioengineering, London, SW7 2AZ, UK.
authors: Meng-Xing
authors: MX
authors: Tang
keywords: (110.0113) Imaging through turbid media; (170.1065) Acousto-optics
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