title: Association between miR-125a rs12976445 and survival in breast cancer patients.
abstract: MicroRNAs (miRNAs) act as an oncogene or a tumor suppressor by negatively regulating target genes. Genetic variants in miRNA genes confer susceptibility to cancer and risk of death in cancer patients. The aim of this study was to investigate whether miRNA polymorphisms were associated with survival in breast cancer patients. Five miRNA polymorphisms (miR-26a1 rs7372209, miR-125a rs12976445, miR-218 rs11134527, miR-423 rs6505162, and miR-608 rs4919510) were genotyped in 196 breast cancer patients. We found that miR-125a rs12976445 was significantly associated with survival in codominant, recessive, and dominant models. However, only association under the codominant model remained significant after adjustment for lymph node metastasis, TNM stage, estrogen receptor, and progesterone receptor. Furthermore, this effect remained in stratification analysis. In conclusion, our results provide evidence that miR-125a rs12976445 may serve as a prognostic biomarker for breast cancer. Further large-scale studies are required to confirm these findings.
authors: Department of Breast Surgery, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors: Lianghe
authors: L
authors: Jiao
authors: Department of Thyroid and Breast Surgery, Subei People's Hospital, Clinical Medical College of Yangzhou University Yangzhou, Jiangsu, China.
authors: Jiaxin
authors: J
authors: Zhang
authors: Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, Jilin Agricultural University Changchun, Jilin, China.
authors: Yuanyuan
authors: Y
authors: Dong
authors: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China.
authors: Bensong
authors: B
authors: Duan
authors: Department of Pathology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors: Hong
authors: H
authors: Yu
authors: CMC Biobank and Translational Medicine Institute Taizhou, Jiangsu, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors: Haihui
authors: H
authors: Sheng
authors: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors: Junxing
authors: J
authors: Huang
authors: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai Shanghai, China.
authors: Hengjun
authors: H
authors: Gao
keywords: MicroRNA; breast cancer; miR-125a; polymorphism; prognosis
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