title: Diagnosis and treatment of diffuse large B-cell lymphoma in an orangutan (Pongo pygmaeus).
abstract: Lymphoma is a common malignancy observed in companion animals. This type of naturally occurring neoplasia has been uncommonly reported in great apes. Diffuse large B-cell lymphoma was diagnosed in an 8-yr-old captive orangutan (Pongo pygmaeus) with gastrointestinal disease by histologic and immunohistochemical methodologies. The orangutan was treated with three cycles of combination chemotherapy (intravenous Rituxan, cyclophosphamide, doxorubicin, and vincristine). The primate has been in good health and exhibiting normal behaviors for more than 15 mo following treatment.
authors: Offiong F
authors: OF
authors: Ikpatt
authors: Drury
authors: D
authors: Reavill
authors: Jason
authors: J
authors: Chatfield
authors: Susan
authors: S
authors: Clubb
authors: Joseph D
authors: JD
authors: Rosenblatt
authors: Glenn
authors: G
authors: Fonte
authors: Yao-Shan
authors: YS
authors: Fan
authors: Carolyn
authors: C
authors: Cray
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018420:Ape Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D057079:Pongo; D011241:Prednisone / Q000627:therapeutic use; D000069283:Rituximab; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone