title: Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxel-based Morphometry.
abstract: BACKGROUND
  Mindfulness-based interventions (MBIs) have previously been associated with structural gray matter changes in normal healthy adults. However, it remains unknown if standardized MBIs can induce similar changes in older adults and those with health complaints as well. The objective of this investigation was to examine the effect of a standardized MBI on the gray matter tissue of older adults with sleep disturbances.
  
  
  METHODS
  This exploratory single-group pilot longitudinal study examined local gray matter changes over a six-week MBI period. Participants included six older adult community volunteers (M=66.5 years of age, SD=5.5, range=58-75; 66% female) with sleep disturbances recruited through advertisement in local newspapers/flyers posted at a university medical center and affiliated clinics in Los Angeles, CA. The MBI was delivered as a weekly, two-hour, six-session, group-based course in mindfulness meditation. Gray matter was measured voxel-wise pre- and post-intervention.
  
  
  RESULTS
  A significant gray matter increase was identified within the precuneus, possibly implicating meditation-induced changes of the default mode network. In contrast, observed significant gray matter decreases may have been driven by MBI-related remediation of brain architecture subserving sleep complaints.
  
  
  CONCLUSIONS
  Exploratory findings suggest that mindfulness meditation practice is associated with a detectable alteration of cerebral gray matter in older adults.
authors: Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA.
authors: Florian
authors: F
authors: Kurth
authors: USC School of Medicine, Los Angeles, CA 90032, USA.
authors: Eileen
authors: E
authors: Luders
authors: Department of Preventive Medicine, USC School of Medicine, Los Angeles, CA 90032, USA.
authors: Brian
authors: B
authors: Wu
authors: David S
authors: DS
authors: Black
keywords: Aging; Brain imaging; Meditation; Mindfulness; Voxel-based morphometry
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