title: Antimicrobial activity of extracts and isoquinoline alkaloids of selected papaveraceae plants.
abstract: Alkaloidal extracts of seven selected plants of the family Papaveraceae were studied with respect to their activity against six strains of pathogenic bacteria and their alkaloidal fingerprint. Twenty-four alkaloids were determined by GC/MS, and twenty of them identified from their mass spectra, retention times and retention indexes. In the antibacterial assay, three Gram-positive (Enterorococcus faecalis, Staphylococcus aureus and S. hyicus), and three Gram-negative (Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa) strains were used. The most promising antimicrobial activity was shown by the alkaloidal extract of Macleaya cordata with MIC values of 16 μg/mL for Staphylococcus aureus, 32 μg/mL for Enterococcus faecalis and 64 μg/mL for Staphylococcus hyicus and Escherichia coli. All the tested pure isoquinoline alkaloids were considered inactive within the tested concentrations.
authors: Lubomír
authors: L
authors: Opletal
authors: Miroslav
authors: M
authors: Ločárek
authors: Adéla
authors: A
authors: Fraňková
authors: Jakub
authors: J
authors: Chlebek
authors: Jakub
authors: J
authors: Smíd
authors: Anna
authors: A
authors: Hošt'álková
authors: Marcela
authors: M
authors: Safratová
authors: Daniela
authors: D
authors: Hulcová
authors: Pavel
authors: P
authors: Klouček
authors: Miroslav
authors: M
authors: Rozkot
authors: Lucie
authors: L
authors: Cahlíková
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D007546:Isoquinolines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D028101:Papaveraceae / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D007546:Isoquinolines; D010936:Plant Extracts