title: The proposed role of plasma NT pro-brain natriuretic peptide in assessing cardiac remodelling in hypertensive African subjects.
abstract: OBJECTIVE
  Although plasma NT-proBNP differentiates hypertension (HT) with or without left ventricular hypertrophy (LVH) from hypertensive heart failure (HHF), most of the published data are based on studies in Western populations. Also, most previous studies did not consider left ventricular (LV) diastolic function and right ventricular (RV) function. We therefore examined the relation between NT-proBNP on LV and RV remodelling in an African hypertensive cohort.
  
  
  METHODS
  Subjects were subdivided into three groups after echocardiography: hypertensives without LVH (HT) (n = 83); hypertensives with LVH (HT + LVH) (n = 50); and those with hypertensive heart failure (HHF) (n = 77).
  
  
  RESULTS
  Subjects with HHF had significantly higher NT-proBNP levels compared to the HT + LVH group (p < 0.0002). NT-proBNP correlated positively with right atrial area, an indirect measure of RV function.
  
  
  CONCLUSIONS
  NT-proBNP is proposed as a useful biomarker in differentiating hypertension with or without LVH from hypertensive heart failure in black hypertensive subjects.
authors: Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja; Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors: Dike B
authors: DB
authors: Ojji
authors: Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors: Lionel H
authors: LH
authors: Opie
authors: Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors: Sandrine
authors: S
authors: Lecour
authors: Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors: Lydia
authors: L
authors: Lacerda
authors: Department of Medical Laboratory Sciences, University of Abuja Teaching Hospital, Gwagwalada, Abuja.
authors: Olusoji M
authors: OM
authors: Adeyemi
authors: Hatter Institute for Cardiovascular Research in Africa, MRC Inter-Cape Heart Unit, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa ; Soweto Cardiovascular Research Unit, Faculty of Health Sciences, University of the Witwatersrand.
authors: Karen
authors: K
authors: Sliwa
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D044383:Black People; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009549:Nigeria; D010446:Peptide Fragments / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
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