title: Preparation and pharmaceutical evaluation of glibenclamide slow release mucoadhesive buccal film.
abstract: Buccal mucoadhesive systems among novel drug delivery systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Buccal mucoadhesive films can improve the drug therapeutic effect by enhancement of drug absorption through oral mucosa increasing the drug bioavailability via reducing the hepatic first pass effect. The aim of the current study was to formulate the drug as buccal bioadhesive film, which releases the drug at sufficient concentration with a sustain manner reducing the frequency of the dosage form administration. One of the advantagees of this formulation is better patient compliances due to the ease of administration with no water to swallow the product. The mucoadhesive films of glibenclamide were prepared using hydroxypropyl methylcellulose (HPMC) K4M, K15M and Eudragit RL100 polymers and propylene glycol as plasticizer and co-solvent. Films were prepared using solvent casting method, and were evaluated with regard to drug content, thickness, weight variations, swelling index, tensile strength, ex vivo adhesion force and percentage of in vitro drug release. Films with high concentrations of HPMC K4M and K15M did not have favorable appearance and uniformity. The formulations prepared from Eudragit were transparent, uniform, flexible, and without bubble. The highest and the lowest percentages of swelling were observed for the films containing HPMC K15M and Eudragit RL100, respectively. Films made of HPMC K15M had adhesion force higher than those containing Eudragit RL100. Formulations with Eudragit RL100 showed the highest mean dissolution time (MDT). Drug release kinetics of all formulations followed Higuchi's model and the mechanism of diffusion was considered non-Fickian type. It was concluded that formulations containing Eudragit RL100 were more favorable than others with regard to uniformity, flexibility, rate and percentage of drug release.
authors: Department of Pharmaceutics and Novel Drug Delivery Systems Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors: R
authors: R
authors: Bahri-Najafi
authors: Department of Pharmaceutics and Novel Drug Delivery Systems Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors: N
authors: N
authors: Tavakoli
authors: Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors: M
authors: M
authors: Senemar
authors: Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
authors: M
authors: M
authors: Peikanpour
keywords: Buccal film; Eudragit polymer; Glibenclamide; Mucoadhesive
references: Int J Pharm Investig. 2012 Jan;2(1):26-33
references: 23071957
references: J Pharm Pharm Sci. 2000 Sep-Dec;3(3):303-11
references: 11177648
references: J Pharm Pharmacol. 1991 Jul;43(7):457-64
references: 1682457
references: Int J Pharm Investig. 2011 Jan;1(1):42-7
references: 23071919
references: Acta Pharm. 2012 Jun;62(2):237-50
references: 22750821
references: Drug Dev Ind Pharm. 2002 Jan;28(1):77-87
references: 11858527
references: Crit Rev Ther Drug Carrier Syst. 2004;21(5):345-86
references: 15717734
references: Drug Deliv. 2009 Oct;16(7):405-15
references: 19624249
references: J Pharm Bioallied Sci. 2011 Jan;3(1):89-100
references: 21430958
references: J Pharm Pharm Sci. 1998 Jan-Apr;1(1):15-30
references: 10942969
references: Acta Pol Pharm. 2010 May-Jun;67(3):217-23
references: 20524422