title: Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations.
abstract: The aim of the study was the comparison of photo-activity of three types of titanium dioxide (TiO2) micro-dispersions intended for use as UV filters for cosmetic sunscreen products. The dispersions were also investigated with regard to their influence on the stability of photo-protective systems in cosmetic emulsions, their skin penetration/absorption and their photo-toxicity for humans and skin bacterial flora. All the tested micro-dispersions of rutile TiO2 type (agglomerates with diameter 120-150 nm), with primary particle size lower than 100 nm, demonstrated no phototoxic effect and insignificant antimicrobial behaviour. On the other hand, TiO2 with insufficient deactivation of photo-activity had significant negative impact on the stability of other organic UV filters and therefore on the stability of declared UV protective factors (SPF, UVA-PF). The study demonstrated that the level of deactivation of TiO2 is one of the highly important factors for evaluation of UV filters used as sunscreens.
authors: Centre for Organic Compounds, 533 54 Rybitví 296, Czech Republic. Electronic address: lubomir.kubac@cocltd.cz.
authors: L
authors: L
authors: Kubáč
authors: Centre for Organic Compounds, 533 54 Rybitví 296, Czech Republic.
authors: J
authors: J
authors: Akrman
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: K
authors: K
authors: Kejlová
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: H
authors: H
authors: Bendová
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: K
authors: K
authors: Klánová
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: Z
authors: Z
authors: Hladíková
authors: Precheza, nábřeží Dr. E. Beneše 1170/24, 751 52 Přerov, Czech Republic.
authors: P
authors: P
authors: Pikal
authors: Precheza, nábřeží Dr. E. Beneše 1170/24, 751 52 Přerov, Czech Republic.
authors: L
authors: L
authors: Kovaříková
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: L
authors: L
authors: Kašparová
authors: National Institute of Public Health, Šrobárova 48, 100 42 Prague, Czech Republic.
authors: D
authors: D
authors: Jírová
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D001205:Ascorbic Acid / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004396:Coloring Agents / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D009226:Myristates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects; D010316:Particle Size; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D013552:Swine; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D001557:Benzenesulfonates; D004396:Coloring Agents; D009226:Myristates; D013473:Sunscreening Agents; D014867:Water; C008205:isopropyl myristate; C009495:titanium dioxide; D014025:Titanium; D001205:Ascorbic Acid; C014722:2-naphthol orange
keywords: Antimicrobial effect; Micro-dispersion; Phototoxicity; Skin penetration; Titanium dioxide; UV filter