title: Clinical features of catheter-related candidemia at disease onset.
abstract: BACKGROUND
  Early detection of catheter-related candidemia is necessary to ensure that patients receive prompt and appropriate treatment. The aim of the present case-control study is to investigate the clinical features of catheter-related candidemia at disease onset, so as to determine the clinical indications for empiric antifungal therapy.
  
  
  METHODS
  All 41 cases of catheter-related candidemia from September 2009 to August 2011 at a teaching hospital were included in the present study. To determine the characteristics that were risk factors for developing catheter-related candidemia, we compared all cases of catheter-related candidemia with all 107 cases of catheter-related blood stream infection (CRBSI) caused by non-Candida spp.
  
  
  RESULTS
  In comparison with CRBSI due to non-Candida spp., the duration of catheter use was significantly longer in cases of catheter-related candidemia (13.9 ± 9.0 days vs. 23.2 ± 25.2 days). There was also a significant difference in the frequency of pre-antibiotic treatment between catheter-related candidemia and CRBSI due to non-Candida spp. (97.6% [40/41 cases] vs. 44.9% [48/107 cases]). Patients with catheter-related candidemia also had significantly more severe clinical statuses (measured using the Sepsis-related Organ Failure Assessment score) than patients with CRBSI due to non-Candida spp. (7.63 ± 3.65 vs. 5.92 ± 2.81).
  
  
  CONCLUSIONS
  When compared to patients with CRBSI caused by non-Candida spp., patients with catheter-related candidemia had significantly more severe clinical backgrounds, longer duration of catheter use and more frequent prior administration of antibiotic agents.
authors: Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan. yoshinosuke0618@gmail.com.
authors: Yusuke
authors: Y
authors: Yoshino
authors: Yoshitaka
authors: Y
authors: Wakabayashi
authors: Satoshi
authors: S
authors: Suzuki
authors: Kazunori
authors: K
authors: Seo
authors: Ichiro
authors: I
authors: Koga
authors: Takatoshi
authors: T
authors: Kitazawa
authors: Shu
authors: S
authors: Okugawa
authors: Yasuo
authors: Y
authors: Ota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000472:pathogenicity*; D058387:Candidemia / Q000175:diagnosis*; D016022:Case-Control Studies; D055499:Catheter-Related Infections / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
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