title: PART is part of Alzheimer disease.
abstract: It has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal Aβ deposition, should be considered as a 'primary age-related tauopathy' (PART) that is not integral to the continuum of sporadic Alzheimer disease (AD). Here, we examine the evidence that PART has a pathogenic mechanism and a prognosis which differ from those of AD. We contend that no specific property of the entorhinal-hippocampal tau pathology makes it possible to predict either a limited progression or the development of AD, and that biochemical differences await an evidence base. On the other hand, entorhinal-hippocampal tau pathology is an invariant feature of AD and is always associated with its development. Rather than creating a separate disease entity, we recommend the continued use of an analytical approach based on NFT stages and Aβ phases with no inference about hypothetical disease processes.
authors: Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75651, Paris Cedex 13, France, charles.duyckaerts@psl.aphp.fr.
authors: Charles
authors: C
authors: Duyckaerts
authors: Heiko
authors: H
authors: Braak
authors: Jean-Pierre
authors: JP
authors: Brion
authors: Luc
authors: L
authors: Buée
authors: Kelly
authors: K
authors: Del Tredici
authors: Michel
authors: M
authors: Goedert
authors: Glenda
authors: G
authors: Halliday
authors: Manuela
authors: M
authors: Neumann
authors: Maria Grazia
authors: MG
authors: Spillantini
authors: Markus
authors: M
authors: Tolnay
authors: Toshiki
authors: T
authors: Uchihara
mesh_terms: D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D003937:Diagnosis, Differential; D018450:Disease Progression; D018728:Entorhinal Cortex / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D024801:Tauopathies / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins
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