title: Influence of aspheric intraocular lens on frequency doubling technology and contrast sensitivity: a fellow eye study.
abstract: OBJECTIVE
  To evaluate whether implantation of an aspheric intraocular lens (IOL) results in reduced ocular aberrations and improved contrast sensitivity after cataract surgery and, therefore, changes on frequency-doubling technology (FDT) testing.
  
  
  METHODS
  The present prospective clinical study enrolled 25 patients with bilateral cataract (50 eyes), who randomly received either an aspheric (Akreos AO) or a spherical (Akreos Fit) IOL in one eye and the other IOL in the second eye. Assessment 12 months postoperatively included photopic and mesopic contrast sensitivity testing. Higher-order aberrations (HOAs) were computed. FDT testing was divided into four areas to evaluate the variation of the values at different points. The median values of the local pattern thresholds (median area contrast sensitivity [MACS]) obtained with that division were calculated.
  
  
  RESULTS
  The Akreos AO group obtained statistically significantly lower values of HOAs and spherical aberration compared with the Akreos Fit group. There was a statistically significant between-group difference in contrast sensitivity under mesopic conditions at all spatial frequencies. No statistically significant differences were observed in mean deviation and pattern standard deviation. The aspheric IOL exhibited higher MACS in all areas, although a statistically significant difference was reached only in the 20-degree field area (P=0.043).
  
  
  CONCLUSIONS
  Aspheric IOLs significantly reduced spherical aberration and HOAs, improving mesopic contrast sensitivity. Although there was a trend toward slightly improved FDT in the aspheric IOL group, it was not statistically significant.
authors: Division of Ophthalmology, University of São Paulo, São Paulo, SP, Brazil.
authors: Rodrigo França de
authors: RF
authors: Espíndola
authors: Division of Ophthalmology, University of São Paulo, São Paulo, SP, Brazil.
authors: Marcony R
authors: MR
authors: Santhiago
authors: Division of Ophthalmology, University of São Paulo, São Paulo, SP, Brazil.
authors: Mário Luiz Ribeiro
authors: ML
authors: Monteiro
authors: Division of Ophthalmology, University of São Paulo, São Paulo, SP, Brazil.
authors: Newton
authors: N
authors: Kara-Junior
mesh_terms: D057128:Aberrometry; D000328:Adult; D002386:Cataract / Q000473:pathology / Q000503:physiopathology; D002387:Cataract Extraction / Q000379:methods*; D015350:Contrast Sensitivity; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D011474:Prosthesis Design; D011680:Pupil / Q000502:physiology; D012016:Reference Values; D012030:Refractive Errors / Q000503:physiopathology; D018709:Statistics, Nonparametric; D016896:Treatment Outcome