title: Genetics of coronary artery disease - a clinician's perspective.
abstract: Coronary artery disease (CAD) is the major cause of fatality and disability among all cardiovascular diseases (CVD). Intricate interactions of genes and environment dictate the outcomes of CAD. Technological advances in the different fields of genetics including linkage studies (LS), candidate gene studies (CGS) and genome-wide association studies (GWA studies) have augmented the knowledge of pathogenesis of CAD. LS were more successful in identifying genetic variants among monogenic disease. GWA studies were relatively popular in identification of variation in polygenic disease. Until now, GWA studies recognized about 50 loci determining around 6% of the heritability in CAD. Clinical utility of the above knowledge would result in better CAD management, but validation of the variants in native population is warranted for active adoption into the clinic. The major aim of this review is to provide an adequate perspective of our current understanding and advances of genetics in CAD.
authors: Senior Scientist, Apollo Hospitals Educational and Research Foundation (AHERF), Hyderabad, India.
authors: Manda V
authors: MV
authors: Sasidhar
authors: MD Candidate, Alpert Medical School of Brown University, Providence, USA.
authors: Satyajit
authors: S
authors: Reddy
authors: Honorary Assistant Professor, Srinidhi Institute of Science, and Technology, Hyderabad, India.
authors: Ashutosh
authors: A
authors: Naik
authors: Senior Consultant, Cardiology Department, Apollo Hospitals, Hyderabad, India; Adjunct Professor, AHERF, Hyderabad, India. Electronic address: sudhir.r.naik@gmail.com.
authors: Sudhir
authors: S
authors: Naik
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012306:Risk
keywords: Cardiovascular diseases; Genetic variants; Genetics; Pathogenesis
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