title: Asymmetric left ventricular hypertrophy associated with morbid obesity mimicking familial hypertrophic cardiomyopathy.
abstract: Asymmetric septal hypertrophy with systolic anterior motion of the mitral valve is frequently a phenotypic, but not pathognomonic, expression of genetic hypertrophic cardiomyopathy (HCM) with or without obstruction. It can, however, be associated nonspecifically with other forms of increased left ventricular (LV) afterload. We herein report the case of a young man with obesity cardiomyopathy and heart failure who presented with asymmetric septal hypertrophy and marked LV hypertrophy, and endomyocardial biopsy ruled out genetic HCM.
authors: Department of Cardiology, National University Heart Centre, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228. raymond_cc_wong@nuhs.edu.sg.
authors: Raymond Ching-Chiew
authors: RC
authors: Wong
authors: Kong Bing
authors: KB
authors: Tan
mesh_terms: D000328:Adult; D024741:Cardiomyopathy, Hypertrophic, Familial; D003937:Diagnosis, Differential; D004452:Echocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D009767:Obesity, Morbid / Q000150:complications*
references: N Engl J Med. 2002 Aug 1;347(5):305-13
references: 12151467
references: Am J Med. 1976 May 10;60(5):645-53
references: 1020753
references: Am J Cardiol. 1992 Oct 1;70(9):921-4
references: 1529947
references: Expert Rev Cardiovasc Ther. 2005 Mar;3(2):225-30
references: 15853596
references: J Am Soc Echocardiogr. 2006 Aug;19(8):1063-71
references: 16880104
references: Int J Cardiol. 2013 Sep 20;168(1):144-50
references: 23079086
references: J Card Fail. 2008 Apr;14(3):198-202
references: 18381182
references: J Am Coll Cardiol. 2009 Mar 3;53(9):754-62
references: 19245965
references: Circulation. 2010 Jul 27;122(4):352-60
references: 20625114
references: J Vet Intern Med. 2013 Jan-Feb;27(1):62-8
references: 23194177
references: Heart Fail Rev. 2013 Mar;18(2):207-17
references: 22610359
references: Nat Clin Pract Cardiovasc Med. 2007 Sep;4(9):480-90
references: 17712361