title: FUT 2 polymorphism and outcome in very-low-birth-weight infants.
abstract: BACKGROUND
  To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.
  
  
  METHODS
  We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.
  
  
  RESULTS
  Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs.
  14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.
  
  
  CONCLUSIONS
  This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Martin
authors: M
authors: Demmert
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Anne
authors: A
authors: Schaper
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Julia
authors: J
authors: Pagel
authors: Department of Pediatrics, University of Leipzig, Leipzig, Germany.
authors: Corinna
authors: C
authors: Gebauer
authors: Department of Neonatology, Vivantes-Klinikum Berlin-Neukölln, Berlin, Germany.
authors: Michael
authors: M
authors: Emeis
authors: Department of Neonatology, Klinikum Dortmund, Dortmund, Germany.
authors: Friedhelm
authors: F
authors: Heitmann
authors: Department of Pediatrics, University of Cologne, Köln, Germany.
authors: Angela
authors: A
authors: Kribs
authors: Department of Neonatology, Children´s Hospital Auf der Bult, Hanover, Germany.
authors: Jens
authors: J
authors: Siegel
authors: Department of Neonatology, Klinikum Kassel, Kassel, Germany.
authors: Dirk
authors: D
authors: Müller
authors: Department of Neonatology, Krankenhaus Barmherzige Brüder St. Hedwig, Regensburg, Germany.
authors: Annette
authors: A
authors: Keller-Wackerbauer
authors: Department of Neonatology, Klinikum Coesfeld, Coesfeld, Germany.
authors: Hubert
authors: H
authors: Gerleve
authors: Department of Neonatology, Klinikum Aschaffenburg, Aschaffenburg, Germany.
authors: Christian
authors: C
authors: Wieg
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Egbert
authors: E
authors: Herting
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Wolfgang
authors: W
authors: Göpel
authors: Department of Pediatrics, University at Lübeck, Lübeck, Germany.
authors: Christoph
authors: C
authors: Härtel
mesh_terms: D002543:Cerebral Hemorrhage / Q000235:genetics; D020345:Enterocolitis, Necrotizing / Q000235:genetics; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics*; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D019102:Infant, Very Low Birth Weight; D007416:Intestinal Perforation / Q000235:genetics*; D007422:Intestines / Q000002:abnormalities; D008297:Male; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D018805:Sepsis / Q000235:genetics; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase