title: The therapeutic potential of carbon monoxide for inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, are chronic, relapsing and remitting inflammatory disorders of the intestinal tract. Because the precise pathogenesis of IBD remains unclear, it is important to investigate the pathogenesis of IBD and to evaluate new anti-inflammatory strategies. Recent accumulating evidence has suggested that carbon monoxide (CO) may act as an endogenous defensive gaseous molecule to reduce inflammation and tissue injury in various organ injury models, including intestinal inflammation. Furthermore, exogenous CO administration at low concentrations is protective against intestinal inflammation. These data suggest that CO may be a novel therapeutic molecule in patients with IBD. In this review, we present what is currently known regarding the therapeutic potential of CO in intestinal inflammation.
authors: Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Tomohisa
authors: T
authors: Takagi
authors: Kazuhiko
authors: K
authors: Uchiyama
authors: Yuji
authors: Y
authors: Naito
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002248:Carbon Monoxide / Q000276:immunology / Q000627:therapeutic use*; D064426:Gasotransmitters / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D064426:Gasotransmitters; D002248:Carbon Monoxide