title: An observational study to monitor the efficacy and tolerability of levofloxacin 500 mg once daily for treatment of chronic bacterial prostatitis in Saudi Arabia.
abstract: BACKGROUND
  Chronic prostatitis is a common urological problem in men <50-year-old. Untypical uropathogens and an intact blood prostate barrier cause difficulty in using antibiotics to treat the infection.
  
  
  METHODS
  In this open-label, observational study, levofloxacin 500 mg was given once daily for 28 days for treatment of chronic prostatitis. The primary efficacy measurement was the disappearance of all pre-treatment symptoms. Efficacy analysis is based on the per protocol population (PPP), all other analyses use the intent to treat (ITT) population.
  
  
  RESULTS
  The ITT included 154 men and the PPP included 151 (results are for the ITT unless otherwise indicated). Mean age was 42 ± 9 years, common concomitant conditions were diabetes mellitus (7%) and hypertension (5%). All symptoms decreased at day 28. Notably, the rate of dysuria decreased from 86.1% to 10.6%, painful ejaculation from 71% to 2.6% and perineal discomfort from 60.3% to 7.3%. A cure of condition was identified in 58.9%. No treatment failures were reported. Physician-reported adherence to study medication was 96.8%.
  
  
  CONCLUSIONS
  Levofloxacin appears to be an effective antibiotic for treating symptoms of chronic bacterial prostatitis. Levofloxacin was well-tolerated in this population.
authors: Department of Andrology, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia.
authors: Amr Ismail
authors: AI
authors: El Meliegy
authors: Department of Urology, Erfan Hospital, Jeddah, Kingdom of Saudi Arabia.
authors: Mohammed
authors: M
authors: Torky
keywords: Chronic bacterial prostatitis; genito urinary infections; levofloxacin
references: JAMA. 1999 Jul 21;282(3):236-7
references: 10422990
references: Int J Antimicrob Agents. 2008 Aug;32(2):145-53
references: 18571904