title: Pre-emptive peritonsillar infiltration of magnesium sulphate and ropivacaine vs. ropivacaine or magnesium alone for relief of post-adenotonsillectomy pain in children.
abstract: OBJECTIVE
  The randomized, double-blinded, placebo-controlled study evaluated the administration of local infiltration of magnesium combined with ropivacaine to reduce pain scores after pediatric adenotonsillectomy.
  
  
  METHODS
  Sixty one subjects received 5ml solution contained 0.25% ropivacaine plus 5mg/kg magnesium sulphate (Group M+R), 5ml 0.25% ropivacaine (Group R) or 5ml solution contained 5mg/kg magnesium sulphate (Group M). Pain scores in the ward and at home, analgesics received after operation and the adverse effects were recorded.
  
  
  RESULTS
  Compared with group M, patients in group M+R and group R had lower pain scores, less emergence agitation and increased time for first analgesic request. Group M+R had no benefit in reducing pain scores after adenotonsillectomy compared with group R.
  
  
  CONCLUSIONS
  Pre-emptive peritonsillar infiltration of magnesium sulphate 5mg/kg combined with 0.25% ropivacaine couldn't improve analgesia for pediatric adenotonsillectomy compared with 0.25% ropivacaine alone. However, Group M+R had less incidence of emergence agitation. Compared with group M, both of group M+R and group R had better postoperative analgesia.
authors: Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors: Jiehao
authors: J
authors: Sun
authors: Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, China.
authors: Xiuying
authors: X
authors: Wu
authors: Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors: Xiyue
authors: X
authors: Zhao
authors: Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
authors: Feifei
authors: F
authors: Chen
authors: Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address: 16387706@qq.com.
authors: Weijian
authors: W
authors: Wang
mesh_terms: D000233:Adenoidectomy; D000293:Adolescent; D000577:Amides / Q000008:administration & dosage / Q000627:therapeutic use*; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000453:epidemiology; D011595:Psychomotor Agitation / Q000209:etiology; D000077212:Ropivacaine; D014068:Tonsillectomy
chemical_list: D000577:Amides; D000700:Analgesics; D000779:Anesthetics, Local; D008278:Magnesium Sulfate; D000077212:Ropivacaine
keywords: Adenotonsillectomy; Agitation; Magnesium sulphate; Ropivacaine