title: Associations between visceral fat and liver fat with insulin sensitivity and metabolic risk in obese adolescents.
abstract: We examined the joint and independent associations between VAT and LF with insulin sensitivity (IS) and lipids in seventy-one obese adolescents (BMI ≥ 95th, 14.9 ± 1.8 years). VAT was assessed by magnetic resonance imaging, and LF was quantified by proton magnetic resonance spectroscopy. IS was evaluated by a 3 -h hyperinsulinemic (80 mU·m(-2)·min(-1)) euglycemic clamp. Independent associations between VAT and LF on metabolic variables were assessed in mutually adjusted multivariate models. The joint association between VAT and LF on metabolic variables was assessed by categorizing participants into a low VAT + low LF group (n = 35), high VAT + low LF group (n = 26), or high VAT + high LF group (n = 10), based on a VAT median split (1.17 kg) and high (≥5%) and low (<5%) LF. Both VAT and LF were independently associated with fasting insulin, 2 h insulin, insulin AUC, IS, and triglycerides (P < 0.05). Adolescents with high VAT + high LF had higher 2 h glucose, glucose AUC, 2 h insulin, triglycerides, and lower insulin sensitivity compared to adolescents with high VAT only (P < 0.025 for all). In obese adolescents, VAT and LF were independently associated with insulin sensitivity and dyslipidemia, and the concomitant presence of VAT and LF is strongly associated with metabolic risk factors.
authors: a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.
authors: Ruth E
authors: RE
authors: Brown
authors: a School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.
authors: Jennifer L
authors: JL
authors: Kuk
authors: b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.|c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224, USA.
authors: Ingrid
authors: I
authors: Libman
authors: b Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC; Pittsburgh, PA 15224, USA.|c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224, USA.
authors: Michelle
authors: M
authors: Rivera-Vega
authors: c Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Ave., Faculty Pavilion (6102), Pittsburgh, PA 15224, USA.
authors: SoJung
authors: S
authors: Lee
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000378:metabolism*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D007328:Insulin
keywords: Visceral fat; adolescents; graisse hépatique; graisse viscérale; insulin sensitivity; liver fat; sensibilité à l’insuline