title: Accuracy of Monte Carlo simulations compared to in-vivo MDCT dosimetry.
abstract: OBJECTIVE
  The purpose of this study was to assess the accuracy of a Monte Carlo simulation-based method for estimating radiation dose from multidetector computed tomography (MDCT) by comparing simulated doses in ten patients to in-vivo dose measurements.
  
  
  METHODS
  MD Anderson Cancer Center Institutional Review Board approved the acquisition of in-vivo rectal dose measurements in a pilot study of ten patients undergoing virtual colonoscopy. The dose measurements were obtained by affixing TLD capsules to the inner lumen of rectal catheters. Voxelized patient models were generated from the MDCT images of the ten patients, and the dose to the TLD for all exposures was estimated using Monte Carlo based simulations. The Monte Carlo simulation results were compared to the in-vivo dose measurements to determine accuracy.
  
  
  RESULTS
  The calculated mean percent difference between TLD measurements and Monte Carlo simulations was -4.9% with standard deviation of 8.7% and a range of -22.7% to 5.7%.
  
  
  CONCLUSIONS
  The results of this study demonstrate very good agreement between simulated and measured doses in-vivo. Taken together with previous validation efforts, this work demonstrates that the Monte Carlo simulation methods can provide accurate estimates of radiation dose in patients undergoing CT examinations.
authors: Departments of Biomedical Physics and Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024.
authors: Maryam
authors: M
authors: Bostani
authors: United States Air Force, Keesler Air Force Base, Biloxi, Mississippi 39534.
authors: Jonathon W
authors: JW
authors: Mueller
authors: Departments of Biomedical Physics and Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024.
authors: Kyle
authors: K
authors: McMillan
authors: University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.
authors: Dianna D
authors: DD
authors: Cody
authors: Departments of Biomedical Physics and Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024.
authors: Chris H
authors: CH
authors: Cagnon
authors: Departments of Biomedical Physics and Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024.
authors: John J
authors: JJ
authors: DeMarco
authors: Departments of Biomedical Physics and Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024.
authors: Michael F
authors: MF
authors: McNitt-Gray
mesh_terms: D006801:Humans; D009010:Monte Carlo Method; D061330:Multidetector Computed Tomography; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011874:Radiometry; D015203:Reproducibility of Results
references: Ann ICRP. 2007;37(2-4):1-332
references: 18082557
references: Med Phys. 2009 Mar;36(3):1025-38
references: 19378763
references: Med Phys. 1998 Jan;25(1):1-11
references: 9472820
references: Phys Med Biol. 1999 Sep;44(9):2213-25
references: 10495116
references: Health Phys. 2008 Nov;95(5):502-7
references: 18849682
references: Med Phys. 2011 Jan;38(1):397-407
references: 21361208
references: Radiology. 2011 May;259(2):311-6
references: 21502387
references: Eur Radiol. 2008 Apr;18(4):759-72
references: 18066555
references: Med Phys. 2014 Nov;41(11):112101
references: 25370652
references: Med Phys. 2010 Apr;37(4):1816-25
references: 20443504
references: Med Phys. 2009 Jun;36(6):2154-64
references: 19610304
references: Phys Med Biol. 2003 Aug 21;48(16):2645-63
references: 12974580
references: J Appl Clin Med Phys. 2011 Jan 31;12(2):3326
references: 21587174
references: N Engl J Med. 2007 Nov 29;357(22):2277-84
references: 18046031
references: J Appl Clin Med Phys. 2011 Nov 15;12(4):3589
references: 22089016
references: Med Phys. 2012 Jun;39(6):2985-96
references: 22755683
references: Br J Radiol. 2008 May;81(965):362-78
references: 18440940
references: Radiat Prot Dosimetry. 2011 Sep;147(1-2):314-6
references: 21778155
references: Br J Radiol. 2002 Oct;75(898):819-30
references: 12381691
references: Radiographics. 2010 Jul-Aug;30(4):1057-67
references: 20631368
references: Med Phys. 2007 May;34(5):1858-73
references: 17555267
references: Ann ICRP. 1991;21(1-3):1-201
references: 2053748
references: Phys Med Biol. 2005 Sep 7;50(17):3989-4004
references: 16177525
references: Phys Med Biol. 2009 Feb 7;54(3):497-512
references: 19124953
references: AJR Am J Roentgenol. 2014 Apr;202(4):703-10
references: 24660695
references: Med Phys. 2012 Aug;39(8):5212-28
references: 22894446
references: Med Phys. 2011 Feb;38(2):820-9
references: 21452719
references: J Am Coll Radiol. 2010;7(2):87-9
references: 20142079
references: Radiology. 2008 Oct;249(1):220-7
references: 18796678
references: Med Phys. 2013 Jan;40(1):013901
references: 23298124
references: Phys Med Biol. 2007 May 7;52(9):2583-97
references: 17440254
references: Cancer Inform. 2007;4:25-31
references: 19390662