title: Addition of all-trans-retinoic acid to omeprazole and sucralfate therapy improves the prognosis of gastric dysplasia.
abstract: OBJECTIVE
  To investigate the efficacy of all-trans retinoic acid (ATRA) in human gastric dysplasia.
  
  
  METHODS
  In this double-blind study, patients with precancerous gastric dysplasia with or without intestinal metaplasia (IM) received either conventional treatment consisting of omeprazole and sucralfate (control group) or conventional treatment plus ATRA. Gastric mucosal biopsies were performed before and after drug treatment and were analysed histologically; expression of retinoblastoma (Rb) protein and HER2 protein in gastric mucosa were measured using immunohistochemistry.
  
  
  RESULTS
  A total of 122 patients were included in the study, 63 in the ATRA group and 59 in the control group. In the ATRA group, dysplasia was attenuated in 43 out of 63 patients (68%) compared with 22 out of 59 patients (37%) in the control group; however, IM was not affected by treatment in either group. ATRA treatment was associated with significantly increased Rb expression and decreased HER2 expression in gastric mucosa.
  
  
  CONCLUSIONS
  The use of conventional therapy plus ATRA for gastric dysplasia was associated with improved efficacy compared with conventional therapy alone. It was also accompanied by increased Rb expression and decreased HER2 expression in gastric mucosa. The addition of ATRA to conventional therapy for gastritis may improve the prognosis of gastric dysplasia.
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Jianjun
authors: J
authors: Jin
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Xiaozhen
authors: X
authors: Li
authors: Department of Pathology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Luqi
authors: L
authors: Xing
authors: Clinical Laboratory, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Yongchao
authors: Y
authors: Chang
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Lijuan
authors: L
authors: Wu
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Zhe
authors: Z
authors: Jin
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Xiuli
authors: X
authors: Su
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Yanli
authors: Y
authors: Bai
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Yufeng
authors: Y
authors: Zheng
authors: Clinical Laboratory, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Yalin
authors: Y
authors: Jiang
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Xiao
authors: X
authors: Zhao
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors: Lan
authors: L
authors: Lu
authors: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China gaoq@mail.haust.edu.cn.
authors: Qiang
authors: Q
authors: Gao
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000378:metabolism; D011379:Prognosis; D016160:Retinoblastoma Protein / Q000378:metabolism; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D013392:Sucralfate / Q000008:administration & dosage*; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D016160:Retinoblastoma Protein; D013392:Sucralfate; D014212:Tretinoin; D009853:Omeprazole
keywords: All-trans-retinoic acid; HER2; gastric dysplasia; intestinal metaplasia; retinoblastoma gene