title: False-positive serology following intravenous immunoglobulin and plasma exchange through transfusion of fresh frozen plasma in a patient with pemphigus vulgaris.
abstract: Intravenous immunoglobulin therapy and plasma exchange through transfusion of fresh frozen plasma are therapeutic options for patients with refractory pemphigus vulgaris. Passive acquisition of various clinically important antibodies through these therapies can occur, leading to false serology and negatively affecting patients' clinical care. It is recommended that dermatologists recognize the possibility of these phenomena and interpret them appropriately. Here, we report false-positive serology following intravenous immunoglobulin therapy and plasma exchange through transfusion of fresh frozen plasma in a patient with refractory pemphigus vulgaris. We also discuss the measure for misinterpretation and unnecessary clinical intervention.
authors: Department of Dermatology, Shizuoka Municipal Shimizu Hospital, Shizuoka, Japan.
authors: Hisashi
authors: H
authors: Nomura
authors: Haruki
authors: H
authors: Honda
authors: Shohei
authors: S
authors: Egami
authors: Tomoaki
authors: T
authors: Yokoyama
authors: Atsushi
authors: A
authors: Fujimoto
authors: Makiko
authors: M
authors: Ishikawa
authors: Makoto
authors: M
authors: Sugiura
mesh_terms: D000328:Adult; D005189:False Positive Reactions; D006510:Hepatitis B Antibodies / Q000097:blood; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects; D008297:Male; D010392:Pemphigus / Q000276:immunology* / Q000628:therapy*; D010951:Plasma Exchange / Q000009:adverse effects
chemical_list: D006510:Hepatitis B Antibodies; D016756:Immunoglobulins, Intravenous
keywords: false serology; fresh frozen plasma; intravenous immunoglobulin; pemphigus vulgaris; plasma exchange