title: Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study.
abstract: Dopamine and serotonin have been indirectly found to be associated with generalized anxiety disorder (GAD). The aims of this study were to examine the availabilities of the striatal dopamine transporter (DAT) and the midbrain serotonin transporter (SERT) in patients with GAD. 12 patients with GAD and 12 sex-matched, age-matched, and smoking status-matched healthy controls were recruited. The availabilities of DAT and SERT were approximated using single-photon emission computed tomography, with [Tc]TRODAT-1 and [I]ADAM as the ligands. There were several missing data for six participants with GAD in the ADAM study because of a lack of the radioligand at the time of the experiment. The DAT availability in the striatum was significantly lower in the patients with GAD than in the healthy controls. However, the SERT availability did not differ between the two groups. The results with respect to the striatal DAT level suggested a potential role in the pathophysiology of GAD.
authors: aDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine bAddiction Research Center cDepartment of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan dDepartment of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.
authors: Lan-Ting
authors: LT
authors: Lee
authors: Hsin Chun
authors: HC
authors: Tsai
authors: Mei Hung
authors: MH
authors: Chi
authors: Wei Hung
authors: WH
authors: Chang
authors: Kao Chin
authors: KC
authors: Chen
authors: I Hui
authors: IH
authors: Lee
authors: Po See
authors: PS
authors: Chen
authors: Wei Jen
authors: WJ
authors: Yao
authors: Nan Tsing
authors: NT
authors: Chiu
authors: Yen Kuang
authors: YK
authors: Yang
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000523:psychology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands