title: Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1.
abstract: Heme oxygenase-1 (HO-1) is an inducible rate-controlling enzyme of heme catabolism. The cytoprotective function of HO-1 activity has been verified in multiple studies, and together with its by-products is considered a key component of the cellular stress response. The transcriptional induction of HO-1 has been largely studied in response to multiple forms of stressful stimuli but our understanding of HO-1 post-transcriptional control mechanisms in neuronal cells is currently lacking. In the present report we show the involvement of the RNA-binding proteins (RBPs) embryonic lethal abnormal vision (ELAV) in the regulation of HO-1 gene expression. Our study demonstrates a specific binding between HO-1 messenger RNA (mRNA) and ELAV proteins, accompanied by an increased expression of HO-1 at protein level, in a human neuroblastoma cell line treated with hemin. Clarifying the induction of HO-1 expression at post-transcriptional level may open therapeutic perspectives for treatments associated with the modulation of HO-1 expression.
authors: Department of Drug Sciences, Section of Pharmacology, University of Pavia Pavia, Italy.
authors: Marialaura
authors: M
authors: Amadio
authors: Department of Medicine and Health Sciences, University of Molise Campobasso, Italy ; Inter-University Consortium "SannioTech" Benevento, Italy.
authors: Giovanni
authors: G
authors: Scapagnini
authors: Department of Medicine and Health Sciences, University of Molise Campobasso, Italy.
authors: Sergio
authors: S
authors: Davinelli
authors: Inter-University Consortium "SannioTech" Benevento, Italy ; Department of Biomedical Sciences, University of Catania Catania, Italy.
authors: Vittorio
authors: V
authors: Calabrese
authors: Department of Drug Sciences, Section of Pharmacology, University of Pavia Pavia, Italy.
authors: Stefano
authors: S
authors: Govoni
authors: Department of Drug Sciences, Section of Pharmacology, University of Pavia Pavia, Italy.
authors: Alessia
authors: A
authors: Pascale
keywords: ELAV; heme oxygenase-1; hemin; post-transcriptional regulation
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