title: Atmospheric pressure plasma CVD as a tool to functionalise wound dressings.
abstract: The main goal of this investigation was the preparation of an antibacterial layer system for additional modification of wound dressings with atmospheric plasma. Furthermore, the modified wound dressings were checked on there bactericidal and cytotoxic activity. The layer system was applied by using a novel atmospheric pressure plasma chemical vapour deposition technique on a variety of textile substrates which are suitable as wound dressing materials. The layer system composed of silicon dioxide with in situ generated embedded silver nanoparticles. The bactericidal activity of the produced wound dressings was investigated against different bacteria like Staphylococcus aureus and Klebsiella pneumoniae while the cytotoxic potential of the coated wound dressings was verified using human keratinocytes. Even at low concentrations of silver precursor a strong antibacterial effect was observed in direct contact with S. aureus and K. pneumoniae. Furthermore, extractions produced from the coated textiles showed a good antibacterial effect. By means of optimised coating parameters a therapeutic window for those wound dressings could be identified. Consequently, the atmospheric pressure plasma chemical vapour deposition technique promise an effective and low cost modification of wound dressing materials.
authors: Innovent e.V., Pruessingstraße 27B, 07745, Jena, Germany, ss2@innovent-jena.de.
authors: Sebastian
authors: S
authors: Spange
authors: Andreas
authors: A
authors: Pfuch
authors: Cornelia
authors: C
authors: Wiegand
authors: Oliver
authors: O
authors: Beier
authors: Uta C
authors: UC
authors: Hipler
authors: Bernd
authors: B
authors: Grünler
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001274:Atmospheric Pressure; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001458:Bandages / Q000382:microbiology*; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000494:pharmacology*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000494:pharmacology; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D058626:Plasma Gases / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D058626:Plasma Gases; D012834:Silver
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