title: Donor kidney glomerular filtration rate and donor/recipient body surface area ratio influence graft function in living related kidney transplantation.
abstract: OBJECTIVE
  This study seeks to account for the possibility that single kidney glomerular filtration rate (SKGFR) and donor/recipient (D/R) body surface area (BSA) ratio could act as cofactors for evaluating potential living related donors.
  
  
  METHODS
  The study population included 204 cases of LKRs with a functional graft that were regularly followed up for more than 2 years. Based on SKGFR and D/R BSA ratio, the recipients were divided into six groups: group A (SKGFR < 40 mL/min, D/R BSA ratio ≤ 0.8), group B (SKGFR < 40 mL/min, 0.8 < D/R BSA ratio < 1.2), group C (SKGFR < 40 mL/min, D/R BSA ratio ≥ 1.2), group D (SKGFR ≥ 40 mL/min, D/R BSA ratio ≤ 0.8), group E (SKGFR ≥ 40 mL/min, 0.8 < D/R BSA ratio < 1.2), and group F (SKGFR ≥ 40 mL/min, D/R BSA ratio ≥ 1.2). The database included donor, recipient, and transplant variables. Renal function of the recipients was recorded at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months, and 24 months post-transplantation, respectively.
  
  
  RESULTS
  The declining rate of SCr and graft eGFR in stable periods post-transplantation in group A were always worse than the other five groups, and the difference was statistically significant (p < 0.05). The declining rate of SCr and graft eGFR in stable periods post-transplantation in groups C and F were always better than the other four groups, and the difference was statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  Both SKGFR and D/R BSA ratio should be considered for choosing potential living related donors. Donors with SKGFR < 40 mL/min and D/R BSA ratio ≤ 0.8 should be carefully selected. Satisfactory graft function in donors with SKGFR < 40 ml could be achieved if their D/R BSA ratio is >0.8.
authors: Kidney Transplantation Center, the First Affiliated Hospital of Zhengzhou University, Key Disciplines Laboratory Clinical-Medicine Henan , Zhengzhou , People's Republic of China and.
authors: Li
authors: L
authors: Jinfeng
authors: Liu
authors: L
authors: Jia
authors: Guo
authors: G
authors: Tao
authors: Shang
authors: S
authors: Wenjun
authors: Pang
authors: P
authors: Xinlu
authors: Feng
authors: F
authors: Yonghua
authors: Feng
authors: F
authors: Guiwen
mesh_terms: D000328:Adult; D001830:Body Surface Area; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Body surface area; glomerular filtration rate; living related kidney recipients