title: Eating disorder psychopathology, brain structure, neuropsychological correlates and risk mechanisms in very preterm young adults.
abstract: This study investigates the prevalence of eating disorder (ED) psychopathology, neuropsychological function, structural brain correlates and risk mechanisms in a prospective cohort of very preterm (VPT) young adults. We assessed ED psychopathology and neuropsychological correlates in 143 cohort individuals born at <33 weeks of gestation. Structural brain correlates and risk factors at birth, in childhood and adolescence, were investigated using prospectively collected data throughout childhood/adolescence. VPT-born individuals had high levels of ED psychopathology at age 21 years. Executive function did not correlate with ED symptomatology. VPT adults presenting with ED psychopathology had smaller grey matter volume at age 14/15 years in the left posterior cerebellum and smaller white matter volume in the fusiform gyrus bilaterally, compared with VPT adults with no ED psychopathology. Caesarean delivery predicted engaging in compensatory behaviours, and severe eating difficulty at age 14 years predicted ED symptomatology in young adulthood. VPT individuals are at risk for ED symptomatology, with evidence of associated structural alterations in posterior brain regions. Further prospective studies are needed to clarify the pathways that lead from perinatal/obstetric complications to ED and relevant neurobiological mechanisms. © 2015 The Authors. European Eating Disorders Review published by John Wiley &Sons, Ltd.
authors: Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London, UK.
authors: Nadia
authors: N
authors: Micali
authors: Radha
authors: R
authors: Kothari
authors: Kie Woo
authors: KW
authors: Nam
authors: Elena
authors: E
authors: Gioroukou
authors: Muriel
authors: M
authors: Walshe
authors: Matthew
authors: M
authors: Allin
authors: Larry
authors: L
authors: Rifkin
authors: Robin M
authors: RM
authors: Murray
authors: Chiara
authors: C
authors: Nosarti
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology / Q000503:physiopathology*; D001931:Brain Mapping; D001068:Feeding and Eating Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D011599:Psychopathology; D012306:Risk; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: brain structure; eating disorders; neuropsychology; perinatal complications; preterm