title: Studies with emulsion containing trans-resveratrol: in vitro release profile and ex vivo human skin permeation.
abstract: Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The trans-resveratrol release kinetic followed the Higushi's model (R(2) = 0.9926) with steady-state diffusion flux and lag time of 138.5 µg cm(-2) h(-1) and 0.49 h, respectively. It showed a percentage at 64.96 % for permeation. Thus, the results suggest that the emulsion studied is a potential vehicle for transresveratrol administration by transdermal route.
authors: Priscila Aparecida
authors: PA
authors: de Almeida
authors: Michele Campos
authors: MC
authors: Alves
authors: Hudson Caetano
authors: HC
authors: Polonini
authors: Stephane Lima
authors: SL
authors: Calixto
authors: Tiago Brum
authors: TB
authors: Braga Gomes
authors: Alexandre Augusto
authors: AA
authors: Barros Lataliza
authors: Cristiano Dias
authors: CD
authors: da Silveira Ramos
authors: Nádia Rezende
authors: NR
authors: Barbosa Raposo
authors: Anderson
authors: A
authors: de Oliveira Ferreira
authors: Universidade Federal de Juiz de Fora, Rua Jose Lourenco Kelmer, s/n, Campus Universitario, 36036-900 Juiz de Fora, MG, Brazil. marcosbrand2012@gmail.com.
authors: Antônio
authors: A
authors: Fernandes Brandão
mesh_terms: D000279:Administration, Cutaneous; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010539:Permeability; D000077185:Resveratrol; D012869:Skin Absorption; D013267:Stilbenes / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004655:Emulsions; D013267:Stilbenes; D000077185:Resveratrol