title: Orally delivered sour cherry seed extract (SCSE) affects cardiovascular and hematological parameters in humans.
abstract: In the present study, we investigated the effects of sour cherry seed extract (SCSE) on a variety of systemic processes that contribute to general health and viability of human subjects. The experiments were conducted according to a double-blind protocol in which six healthy individuals were administered 250-mg/day SCSE for 14 days, while four were treated with placebo. Peripheral blood was collected before and after the treatment period. Samples were analyzed for levels of selected cells, enzymes, or metabolites. Subjects that received SCSE showed increases in the values of mean cell volume, serum transferrin, mean peroxidase index, and representation of peripheral blood lymphocytes. On the other hand, decreases were observed in circulating neutrophils and ferritin levels. Changes observed in the present study do not fit into a clear pattern that might yield additional in-depth understanding of SCSE-mediated alterations in physiologic responses. The most encouraging result of the present study is the absence of any indication of toxicity by subjects consuming the extract.
authors: Division of Clinical Immunology, Institute of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors: Zoltan
authors: Z
authors: Csiki
authors: Agnes
authors: A
authors: Papp-Bata
authors: Attila
authors: A
authors: Czompa
authors: Aniko
authors: A
authors: Nagy
authors: Istvan
authors: I
authors: Bak
authors: Istvan
authors: I
authors: Lekli
authors: Andras
authors: A
authors: Javor
authors: David D
authors: DD
authors: Haines
authors: Gyorgy
authors: G
authors: Balla
authors: Arpad
authors: A
authors: Tosaki
mesh_terms: D000328:Adult; D048429:Cell Size; D004311:Double-Blind Method; D005260:Female; D005293:Ferritins / Q000097:blood; D064368:Healthy Volunteers; D006403:Hematologic Tests; D051547:Heme Oxygenase-1 / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects; D009195:Peroxidase / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D014168:Transferrin / Q000737:chemistry
chemical_list: D010936:Plant Extracts; D014168:Transferrin; D005293:Ferritins; D009195:Peroxidase; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
keywords: heme oxygenase-1; human subjects; sour cherry seed extract