title: Non-tuberculous mycobacterial infections after solid organ transplantation: a survival analysis.
abstract: The relationship of non-tuberculous mycobacterial (NTM) infections and survival among solid organ transplant recipients is unknown. We conducted a retrospective cohort study to measure the impact of NTM infection on survival in this patient population, comparing the effect of Mycobacterium abscessus infection with that of infections due to other pathogenic NTM species. We identified 33 patients with NTM infection post-transplantation, 18 with infection that was diagnosed within the first year. Although drug resistance was common among M. abscessus isolates, patients with M. abscessus infection did not have increased mortality compared with patients with other types of NTM infections (p 0.64). In contrast, we observed a significant association overall between early NTM infection and 3-year mortality post-transplantation (hazard ratio 8.76, 95% CI 2.69-28.57). The mortality burden of NTM infection following transplantation may be due to factors other than the virulence of the organisms. Multicentre studies are needed to identify the optimal approach for diagnosing and treating these uncommon but serious infections.
authors: Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
authors: S A
authors: SA
authors: Longworth
authors: Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
authors: E A
authors: EA
authors: Blumberg
authors: Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
authors: T D
authors: TD
authors: Barton
authors: Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: christopher.vinnard@drexelmed.edu.
authors: C
authors: C
authors: Vinnard
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000401:mortality*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D016377:Organ Transplantation / Q000009:adverse effects* / Q000401:mortality*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000995:Antitubercular Agents
keywords: Drug resistance; Mycobacterium abscessus; epidemiology; non-tuberculous mycobacteria; transplantation
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