title: Macrophage activation syndrome in a newborn infant born to a mother with autoimmune disease.
abstract: Macrophage activation syndrome (MAS) is a complication of rheumatic disorders characterized by cytopenia, multiple organ dysfunction and coagulopathy associated with an inappropriate activation of macrophage. In neonatal lupus erythematosus, MAS is rare but fatal, requiring early diagnosis and treatment for optimal outcome. We report a case of MAS in a neonate born to a mother with autoimmune disease, improved by treatment with steroid, intravenous immunoglobulin and cyclosporine.
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: J H
authors: JH
authors: Park
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: S H
authors: SH
authors: Kim
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: H J
authors: HJ
authors: Kim
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: S J
authors: SJ
authors: Lee
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: D C
authors: DC
authors: Jeong
authors: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
authors: S Y
authors: SY
authors: Kim
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage*; D042241:Early Diagnosis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D055501:Macrophage Activation Syndrome / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D016572:Cyclosporine
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