title: Bilateral recurrent ocular surface squamous cell cancer associated with epidermodysplasia verruciformis.
abstract: A 17-year-old boy, presented with a 2-year history of bilateral, recurrent ocular surface mass. Dermatological evaluation revealed the presence of multiple hypopigmented macules over his body. Skin biopsy showed features typical of epidermodysplasia verruciformis. Topical mitomycin C (0.02%) was administered in both eyes for 6 weeks (three 1-week cycles over 6 weeks). While the mass in the left eye regressed, the mass in the right eye was excised under guidance of intraoperative frozen section. Triple-freeze thaw cryotherapy of the surrounding conjunctiva along with placement of amniotic membrane graft was performed. Postoperative mitomycin C (0.02%) was administered for another 6 weeks (three 1-week cycles over 6 weeks) in both eyes. At 4 years of follow-up, no recurrence has been noted.
authors: Department of Ophthalmology, R P Centre, All India Institute of Medical Sciences, New Delhi, India.
authors: Tarun
authors: T
authors: Arora
authors: Department of Ophthalmology, R P Centre, All India Institute of Medical Sciences, New Delhi, India.
authors: Sourabh
authors: S
authors: Sharma
authors: Department of Ophthalmology, R P Centre, All India Institute of Medical Sciences, New Delhi, India.
authors: Namrata
authors: N
authors: Sharma
authors: Department of Ophthalmology, R P Centre, All India Institute of Medical Sciences, New Delhi, India.
authors: Jeewan S
authors: JS
authors: Titiyal
mesh_terms: D000293:Adolescent; D000650:Amnion / Q000601:surgery; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000628:therapy; D003452:Cryosurgery; D004819:Epidermodysplasia Verruciformis / Q000150:complications*; D005134:Eye Neoplasms / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin
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