title: Nano-liposomes of entrapment lidocaine hydrochloride on in vitro permeability of narcotic.
abstract: In order to explore two kinds of nano-liposomes in lidocaine hydrochloride nano-liposomes on in vitro permeability of drug, and conduct comparison and analysis, this paper investigates cumulative infiltration situation of lidocaine hydrochloride flexible nano-liposomes and ordinary nano-liposomes by using modified Franz diffusion pool on mice vitro skin. Cumulative osmotic quantity of lidocaine hydrochloride flexible nano-liposomes for 9h was higher than ordinary nano-liposomes. (t)max(Maximum osmotic quantity time) of lidocaine hydrochloride flexible nano-liposomes and ordinary nano-liposomes in mice skin was 5 and 60min, the former (C)max (maximum dosage time) was 1.2 times of the latter. Drug was not found in mice plasma of ordinary nano-liposomes group, traces of drugs was detected in 0.5 and 1h in flexible nano-liposomes group, but the concentration was lower than the effective concentration. Compared with the classic skin transparent promoter and ordinary liposome, flexible nano-liposomes have more advantages, but its stability is less than ordinary nano-liposomes because of the addition of surface active substance. Flexible nano-liposomes have great development potential as a carrier of transdermal drug delivery field.
authors: Department of anesthesiology, Weifang People's Hospital, Weifang, China.
authors: Nenghong
authors: N
authors: Sun
authors: Department of spine surgery, Weifang People's Hospital, Weifang, China.
authors: Yanyan
authors: Y
authors: Zhu
authors: Operating theatre, Weifang Seventh People's Hospital, Weifang, China.
authors: Lei
authors: L
authors: Yuan
authors: Department of anesthesiology, Weifang People's Hospital, Weifang, China.
authors: Bao
authors: B
authors: Lang
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D066298:In Vitro Techniques; D008012:Lidocaine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008081:Liposomes; D051379:Mice; D053758:Nanoparticles; D010539:Permeability; D012867:Skin / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D008081:Liposomes; D008012:Lidocaine