title: Growing old with Myc.
abstract: The Myc proto-oncogene has been intensively studied in tumorigenesis and development. A new paper in Cell reports the role of Myc as a determinant of mammalian longevity. Myc heterozygous mice exhibit extended lifespans resulting from alterations in multiple cellular processes distinct from those observed in other longevity models.
authors: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors: Patrick A
authors: PA
authors: Carroll
authors: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: eisenman@fhcrc.org.
authors: Robert N
authors: RN
authors: Eisenman
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism*
chemical_list: C489428:Myc protein, mouse; D016271:Proto-Oncogene Proteins c-myc
references: Cell Rep. 2014 Nov 20;9(4):1349-60
references: 25453755
references: Cell Stem Cell. 2008 Dec 4;3(6):611-24
references: 19041778
references: Cell Metab. 2011 Nov 2;14(5):623-34
references: 22055505
references: Nature. 2013 Jan 17;493(7432):338-45
references: 23325216
references: Annu Rev Physiol. 2013;75:621-44
references: 23190075
references: Cell. 2015 Jan 29;160(3):477-88
references: 25619689
references: Mol Cell Biol. 2005 Aug;25(16):7078-91
references: 16055719
references: Oncogene. 2011 Jul 28;30(30):3305-16
references: 21516129
references: PLoS One. 2013 Sep 06;8(9):e74641
references: 24040302