title: Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats.
abstract: In this paper, the effect and mechanism of Salicornia bigelovii Torr. plant salt (SPS) on blood pressure in Sprague Dawley (SD) rats were investigated. The results showed that the edible salt induced hypertension, but the SPS did not. Organ indices and Hematoxylin-Eosin (HE) staining analysis indicated that SPS had a protective effect on the kidney and liver. In comparison with the edible salt-treated group, nitric oxide (NO) content, angiotensin-II (Ang-II) and endothelin-1 (ET-1) levels in the serum of the SPS-treated group had no obvious changes, but serum creatinine concentration significantly decreased. Moreover, superoxide dismutase (SOD) and Na(+)-K(+)-ATPase activity increased while malondialdehyde (MDA) content decreased in the SPS-treated group. In conclusion, a long-term high salt intake could lead to hypertension. SPS, as a salt substitute, could increase the body's antioxidant ability to protect the kidney and liver from the damage caused by a high salt intake and effectively avoid the occurrence of hypertension.
authors: Department of Biology, Shantou University, Shantou, Guangdong 515063, China. chenmz@stu.edu.cn.
authors: Shumeng
authors: S
authors: Zhang
authors: Mingqian
authors: M
authors: Wei
authors: Chunjie
authors: C
authors: Cao
authors: Yaoyao
authors: Y
authors: Ju
authors: Yanqun
authors: Y
authors: Deng
authors: Tianwen
authors: T
authors: Ye
authors: Zufeng
authors: Z
authors: Xia
authors: Meizhen
authors: M
authors: Chen
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D019663:Chenopodiaceae / Q000737:chemistry*; D002681:China; D004039:Diet, Sodium-Restricted; D006352:Heart Ventricles / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006973:Hypertension / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry*; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000097:blood; D017673:Sodium Chloride, Dietary / Q000009:adverse effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D017365:Spices / Q000032:analysis; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts; D017673:Sodium Chloride, Dietary; D008315:Malondialdehyde; D012964:Sodium; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase