title: From PAWP to "Pop": opening up new pathways to fatherhood.
abstract: Infertility remains a significant problem for many couples. Approximately one in seven couples who attempt to conceive will fail to do so within 1 year. In about 65% of these cases, there is a male component of infertility.1 Despite normal semen parameters, the etiology of infertility remains uncertain in more than 50% of couples.2 Defects in sperm proteins and/ or structures may underlie certain cases of male infertility. Although many men would like to be called "Pop", "Dad", or "Papa", those who are classified with idiopathic male infertility have few options for becoming fathers. Recent studies by Aarabi et al.3 may open the door to new therapies.
authors: Melissa L
authors: ML
authors: Vadnais
authors: Center for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA.
authors: George L
authors: GL
authors: Gerton
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002352:Carrier Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D009865:Oocytes / Q000187:drug effects*; D029589:Seminal Plasma Proteins / Q000494:pharmacology*
chemical_list: D002352:Carrier Proteins; D029589:Seminal Plasma Proteins
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