title: Assessment of drug-related problems in depressive patients.
abstract: BACKGROUND
  Drug-related problems (DRPs) frequently occur in modern medical practice, increasing the morbidity and mortality as well as increasing cost of care.
  
  
  OBJECTIVE
  The study is to evaluate the incidence of DRPs in patients admitted to a psychiatric department.
  
  
  METHODS
  A prospective observational study was conducted for a period of 4 months at Baliga psychiatric hospital. All prescriptions of the study population were screened for DRPs such as adverse drug reactions (ADRs) and potential drug-drug interactions (pDDIs) by using computerized database system.
  
  
  RESULTS
  Out of 120 patients, 19 patients had observed 26 DRPs. Out of 33 patients, 19 patients had observed 26 ADRs and 14 patients had observed 24 pDDIs. The overall incidence of DRPs was 15.83%. Female patients outnumbered the male patients, in which 12 women constitute 10% followed by men 7 (5.83%). The common ADRs observed were hyponatremia and headache. Considering the outcomes, 20 (76.9%) cases recovered from ADRs and 20 (76.9%) of the ADRs were definitely preventable. Majority of ADRs were probable and were found to be mild to moderately severe.
  
  
  CONCLUSIONS
  Age, female gender and polypharmacy were the risk factors for the developing DRPs.
authors: Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences. Manipal University, Manipal, Karnataka, India.
authors: Uday Venkat
authors: UV
authors: Mateti
authors: Department of Clinical Pharmacy, Kalupur Bank Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.
authors: Tarachand
authors: T
authors: Lalwani
authors: Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences. Manipal University, Manipal, Karnataka, India.
authors: Anantha Naik
authors: AN
authors: Nagappa
authors: Department of Psychiatric, Dr. A.V. Baliga Memorial Hospital, Udupi, Karnataka, India.
authors: P V
authors: PV
authors: Bhandary
authors: Department of Psychiatric, Dr. A.V. Baliga Memorial Hospital, Udupi, Karnataka, India.
authors: D
authors: D
authors: Verupaksha
authors: Department of Health Management and Policy, Center for Global Health and College of Pharmacy, University of Michigan, Michigan, USA.
authors: Rajesh
authors: R
authors: Balkrishnan
keywords: Depression; drug-related problems; psychiatric
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