title: WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1.
abstract: WIPI proteins, phosphatidylinositol 3-phosphate (PtdIns3P) binding proteins with β-propeller folds, are recruited to the omegasome following PtdIns3P production. The functions of the WIPI proteins in autophagosome formation are poorly understood. In a recent study, we reported that WIPI2B directly binds ATG16L1 and functions by recruiting the ATG12-ATG5-ATG16L1 complex to forming autophagosomes during starvation- or pathogen-induced autophagy. Our model of WIPI2 function provides an explanation for the PtdIns3P-dependent recruitment of the ATG12-ATG5-ATG16L1 complex during initiation of autophagy.
authors: a London Research Institute; Cancer Research UK ; London , UK.
authors: Hannah C
authors: HC
authors: Dooley
authors: Michael I
authors: MI
authors: Wilson
authors: Sharon A
authors: SA
authors: Tooze
mesh_terms: D000818:Animals; D001343:Autophagy; D002352:Carrier Proteins / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008954:Models, Biological; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D002352:Carrier Proteins; D008055:Lipids; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D018129:Phosphatidylinositol Phosphates; C055525:phosphatidylinositol 3-phosphate
keywords: ATG12–ATG5-ATG16L1; PtdIns3P; PtdIns3P, phosphatidylinositol 3-phosphate; WIPI; autophagosome; autophagy; omegasome