title: Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.
abstract: The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.
authors: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California.
authors: Anaïs
authors: A
authors: Briot
authors: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. arispe@mcdb.ucla.edu.
authors: M Luisa
authors: ML
authors: Iruela-Arispe
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000008:administration & dosage*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000098:blood supply* / Q000628:therapy*; D051881:Receptor, Notch1 / Q000008:administration & dosage*; D051880:Receptors, Notch / Q000037:antagonists & inhibitors*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage*
chemical_list: D007141:Immunoglobulin Fc Fragments; D036341:Intercellular Signaling Peptides and Proteins; D051881:Receptor, Notch1; D051880:Receptors, Notch; D011993:Recombinant Fusion Proteins
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