title: ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?
abstract: Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or obstetric complications associated with presence of antiphospholipid antibodies (aPL) but additional factors would also induce thrombosis. ABO (H) blood groups are known to be closely related to thrombosis, especially non-O blood type with venous events. The aim of this study was to investigate possible role of ABO (H) blood types in the thrombotic events in primary APS (PAPS). Seventy PAPS patients were selected for the study and were divided according to ABO blood group in: O PAPS (n = 26) and non-O PAPS (n = 44). ABO blood group phenotyping was performed by indirect technique. aPL anticardiolipin (aCL) and anti-βeta2 glycoprotein-1 (aβ2GPI) and the concentrations and activities of von Willebrand factor (VWF) were measured with ELISA. Lupus anticoagulant (LA) was detected by coagulation assays. A significant higher frequency of venous events was observed in non-O PAPS group (72.7 vs. 46.2 %, p = 0.040). In contrast, the frequency of arterial events was significantly higher in the O PAPS compared to the non-O PAPS group (69.2 vs. 36.4 %, respectively; p = 0.013). Frequencies of aCL, LA, aβ2GPI and triple aPL positivity were similar in both groups (p > 0.05). VWF antigen (75.54 ± 8.68 vs. 79.51 ± 7.07 IU/dl, p = 0.041) and activity (70.23 ± 11.96 vs. 77.92 ± 13.67 %, p = 0.020) were decreased in O PAPS compared to non-O blood group. VWF:CB/VWF:Ag ratio was similar among groups (p > 0.05). This is the first report that confirms the role of ABO blood system in thrombosis of PAPS and suggests that non-O blood group was related with venous events and O blood group with arterial thrombosis.
authors: Laboratory of Genetics and Molecular Hematology (LIM 31), School of Medicine, University of São Paulo (USP), Av. Dr. Enéas de Carvalho Aguiar, 155, 1° andar, sala 43, São Paulo, SP, 05403-000, Brazil.
authors: Natália Mastantuono
authors: NM
authors: Nascimento
authors: Sergio Paulo
authors: SP
authors: Bydlowski
authors: Rosangela Paula Silva
authors: RP
authors: Soares
authors: Danieli Castro Oliveira
authors: DC
authors: de Andrade
authors: Eloísa
authors: E
authors: Bonfá
authors: Luciana Parente Costa
authors: LP
authors: Seguro
authors: Eduardo Ferreira
authors: EF
authors: Borba
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood*
chemical_list: D000017:ABO Blood-Group System; D001323:Autoantibodies
references: Clin Chem. 1972 Jun;18(6):499-502
references: 4337382
references: Nat Rev Rheumatol. 2011 Jun;7(6):330-9
references: 21556027
references: J Thromb Haemost. 2013 May;11(5):845-54
references: 23506463
references: J Thromb Haemost. 2006 Dec;4(12):2556-62
references: 17059421
references: J Thromb Haemost. 2003 Jan;1(1):33-40
references: 12871537
references: Mediterr J Hematol Infect Dis. 2013 Jul 16;5(1):e2013052
references: 23936623
references: Ann Rheum Dis. 2009 Mar;68(3):397-9
references: 18812393
references: Semin Thromb Hemost. 2012 Jul;38(5):535-48
references: 22740183
references: J Thromb Haemost. 2007 Jul;5(7):1455-61
references: 17425663
references: Am J Med. 1998 Jul;105(1):21-6
references: 9688017
references: Crit Rev Clin Lab Sci. 2012 Jul-Aug;49(4):137-49
references: 22856614
references: J Thromb Haemost. 2010 Feb;8(2):237-42
references: 19874470
references: J Thromb Thrombolysis. 2012 May;33(4):416-21
references: 22466813
references: Thromb Res. 2001 Feb 15;101(4):291-7
references: 11248290
references: Blood Coagul Fibrinolysis. 2010 Dec;21(8):736-43
references: 20881480
references: Clin Chem. 1979 Apr;25(4):596-604
references: 223779
references: CMAJ. 2013 Mar 19;185(5):E229-37
references: 23382263
references: J Thromb Haemost. 2009 Oct;7(10):1737-40
references: 19624461
references: Curr Opin Rheumatol. 2009 Sep;21(5):495-500
references: 19593144
references: J Thromb Haemost. 2006 Feb;4(2):295-306
references: 16420554
references: Thromb Haemost. 2005 Jun;93(6):1147-52
references: 15968401
references: Blood. 2008 Apr 1;111(7):3540-5
references: 18245665
references: Semin Thromb Hemost. 2014 Feb;40(1):49-59
references: 24381150
references: Thromb Haemost. 2013 Dec;110(6):1172-9
references: 24067945
references: Circulation. 2008 Mar 18;117(11):1449-59
references: 18347221
references: Clin Chem. 1983 Jun;29(6):1075-80
references: 6851096
references: Blood. 2009 May 21;113(21):5298-303
references: 19278955
references: J Thromb Haemost. 2008 Jan;6(1):62-9
references: 17973651
references: Clin Chem. 1982 Oct;28(10):2077-80
references: 6812986
references: Arthritis Rheum. 1999 Jul;42(7):1309-11
references: 10403256