title: On the role of 4-hydroxynonenal in health and disease.
abstract: Polyunsaturated fatty acids are susceptible to peroxidation and they yield various degradation products, including the main α,β-unsaturated hydroxyalkenal, 4-hydroxy-2,3-trans-nonenal (HNE) in oxidative stress. Due to its high reactivity, HNE interacts with various macromolecules of the cell, and this general toxicity clearly contributes to a wide variety of pathological conditions. In addition, growing evidence suggests a more specific function of HNE in electrophilic signaling as a second messenger of oxidative/electrophilic stress. It can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress. Moreover, HNE-mediated signaling can largely influence the fate of the cell through modulating major cellular processes, such as autophagy, proliferation and apoptosis. This review focuses on the molecular mechanisms underlying the signaling and regulatory functions of HNE. The role of HNE in the pathophysiology of cancer, cardiovascular and neurodegenerative diseases is also discussed.
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary.
authors: Miklós
authors: M
authors: Csala
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary.
authors: Tamás
authors: T
authors: Kardon
authors: Department of Pediatrics, University of California, San Francisco, CA, USA.
authors: Balázs
authors: B
authors: Legeza
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary.
authors: Beáta
authors: B
authors: Lizák
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary.
authors: József
authors: J
authors: Mandl
authors: Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary.
authors: Éva
authors: É
authors: Margittai
authors: Department of Anesthesiology, University of Colorado, Denver, CO, USA.
authors: Ferenc
authors: F
authors: Puskás
authors: Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
authors: Péter
authors: P
authors: Száraz
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary.
authors: Péter
authors: P
authors: Szelényi
authors: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Budapest, Budapest, Hungary. Electronic address: banhegyi.gabor@med.semmelweis-univ.hu.
authors: Gábor
authors: G
authors: Bánhegyi
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D002468:Cell Physiological Phenomena / Q000502:physiology*; D004194:Disease; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000447:Aldehydes; C027576:4-hydroxy-2-nonenal
keywords: 4-Hydroxynonenal; Electrophilic stress; Lipid peroxidation; Nrf2; Proteostasis