title: Overview of microRNA biology.
abstract: In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of messenger RNAs that contain stretches of sequence complementary to the microRNA. This function can be likened to the function of endogenous or synthetic short interfering RNA. However, microRNA function is more complicated and nuanced than this "on-off" model would suggest. Further, many microRNA targets are themselves noncoding RNAs. In this review, the authors discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
authors: Ashley M
authors: AM
authors: Mohr
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.
authors: Justin L
authors: JL
authors: Mott
mesh_terms: D017398:Alternative Splicing; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D012323:RNA Processing, Post-Transcriptional; D012261:Ribonucleoproteins
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs; D012261:Ribonucleoproteins
references: Essays Biochem. 2013;54:79-90
references: 23829528
references: Cell. 2013 Apr 25;153(3):654-65
references: 23622248
references: Mol Cell. 2010 Jul 9;39(1):133-44
references: 20603081
references: F1000 Biol Rep. 2011;3:15
references: 21876726
references: PLoS One. 2010;5(6):e11264
references: 20582318
references: Nature. 2010 Aug 12;466(7308):835-40
references: 20703300
references: Cell. 2007 Jun 29;129(7):1401-14
references: 17604727
references: Nucleic Acids Res. 2014 Jan;42(Database issue):D86-91
references: 24163105
references: PLoS One. 2011;6(3):e17666
references: 21436881
references: FEBS Lett. 2013 Oct 25;:null
references: 24512851
references: Mol Cell. 2004 Jul 23;15(2):185-97
references: 15260970
references: EMBO Rep. 2008 Jun;9(6):582-9
references: 18483486
references: Hepatology. 2014 Sep;60(3):896-907
references: 24497320
references: Mol Cell. 2014 Jul 3;55(1):138-47
references: 24910097
references: Nat Cell Biol. 2007 Jun;9(6):654-9
references: 17486113
references: Cell Stem Cell. 2012 Mar 2;10(3):327-36
references: 22385659
references: Curr Biol. 2002 Apr 30;12(9):735-9
references: 12007417
references: Cell. 2005 Jan 14;120(1):15-20
references: 15652477
references: Cell Res. 2008 Oct;18(10):997-1006
references: 18766170
references: Mol Cell. 2007 Jul 6;27(1):91-105
references: 17612493
references: Nucleic Acids Res. 2013 Jan;41(Database issue):D239-45
references: 23193281
references: Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11467-72
references: 25049417
references: Tumour Biol. 2014 Oct;35(10):10075-84
references: 25015192
references: Cell Commun Signal. 2014;12:30
references: 24774301
references: EMBO J. 2007 Feb 7;26(3):775-83
references: 17255951
references: Nat Struct Mol Biol. 2012 Mar;19(3):321-7
references: 22343717
references: Nature. 2000 Feb 24;403(6772):901-6
references: 10706289
references: Cell Rep. 2014 Jun 26;7(6):2066-77
references: 24931604
references: Nat Rev Mol Cell Biol. 2003 Jun;4(6):457-67
references: 12778125
references: EMBO J. 2001 Dec 3;20(23):6877-88
references: 11726523
references: Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13
references: 18227514
references: Nat Genet. 2005 May;37(5):495-500
references: 15806104
references: Science. 2007 Feb 23;315(5815):1137-40
references: 17322061
references: Nature. 2008 Sep 4;455(7209):58-63
references: 18668040
references: Nucleic Acids Res. 2011 Jul;39(13):5692-703
references: 21447562
references: Genes Dev. 2009 Feb 15;23(4):433-8
references: 19240131
references: BMC Genomics. 2012;13:44
references: 22276777
references: Int J Biochem Cell Biol. 2010 Aug;42(8):1348-54
references: 20227518
references: EMBO Rep. 2007 Aug;8(8):763-9
references: 17599088
references: Nature. 2008 Sep 4;455(7209):64-71
references: 18668037
references: Nat Cell Biol. 2009 Sep;11(9):1157-63
references: 19701194
references: Oncogene. 2011 Nov 24;30(47):4750-6
references: 21625215
references: Best Pract Res Clin Haematol. 2007 Sep;20(3):425-37
references: 17707831
references: Cell. 2009 Aug 21;138(4):673-84
references: 19703394
references: Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E423-31
references: 22308344
references: Nat Struct Mol Biol. 2006 Jan;13(1):13-21
references: 16369484
references: Mol Cell. 2014 Mar 20;53(6):1031-43
references: 24631284
references: J Immunol. 2010 Jun 1;184(11):6053-9
references: 20410487
references: Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):666-79
references: 23428348
references: Mol Cell. 2008 Oct 24;32(2):276-84
references: 18951094
references: RNA Biol. 2012 Feb;9(2):137-42
references: 22258222
references: Cancer Res. 2008 Oct 1;68(19):8164-72
references: 18829576
references: Genes Dev. 2004 May 1;18(9):975-80
references: 15105377
references: Cancer Res. 2008 Oct 15;68(20):8535-40
references: 18922928
references: Nucleic Acids Res. 2012 Aug;40(14):6821-33
references: 22505577
references: RNA. 2011 Oct;17(10):1795-803
references: 21849429
references: Nat Struct Mol Biol. 2009 Jun;16(6):616-23
references: 19430462
references: Science. 2007 Dec 21;318(5858):1931-4
references: 18048652
references: Nature. 2006 Jan 19;439(7074):283-9
references: 16421561
references: J Biol Chem. 2011 Aug 26;286(34):29828-37
references: 21757701
references: Mol Cell. 2010 Jun 25;38(6):789-802
references: 20620952
references: PLoS One. 2009;4(10):e7566
references: 19859542
references: Nature. 2012 Jun 28;486(7404):541-4
references: 22722835
references: Mol Cell. 2008 Nov 7;32(3):383-93
references: 18995836
references: Science. 2006 Apr 7;312(5770):75-9
references: 16484454
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: Chin J Cancer. 2011 Jun;30(6):371-80
references: 21627859
references: Cell. 2006 Jun 16;125(6):1111-24
references: 16777601
references: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D135-9
references: 16381831
references: J Physiol. 2010 Oct 15;588(Pt 20):4029-37
references: 20724368
references: Cell. 2008 Mar 7;132(5):875-86
references: 18329372
references: Cell. 2012 Oct 26;151(3):521-32
references: 23063654
references: Genomics. 2006 Feb;87(2):225-35
references: 16309881
references: Mol Cell. 2013 Jun 27;50(6):869-81
references: 23747012