title: Genetic heterogeneity of platelet glycoproteins Ia and IIIa is associated with in vitro fertilisation implantation failure.
abstract: Thrombophilic genetic factors have been shown to play an important role in implantation outcome after in vitro fertilisation (IVF). In this pilot study we investigated the frequencies of glycoprotein Ia (GpIa)-C807T and GpIIIa-PlA1/PlA2 polymorphisms in 60 nulligravidae women with a history of unexplained IVF implantation failures and compared them with 60 healthy fertile women. We found statistically significant associations between the GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and IVF implantation failure (odds ratio [OR] = 3.45, 95% confidence interval [CI]: 1.63-7.30, p = 0.001; and OR = 2.86, 95% CI: 1.27-6.45, p = 0.010, respectively) with the risk being higher for combined carriers of GpIa-807T and GpIIIa-PlA2 alleles (OR = 10.13, 95% CI: 2.85-35.99, p < 0.001), suggesting a synergistic effect of the two polymorphisms. The above associations were strongest for the youngest age group. Our results indicate that GpIa-807T and GpIIIa-PlA2 may be susceptibility alleles for IVF implantation failure.
authors: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynaecology , National and Kapodistrian University of Athens, Aretaieio Hospital , Athens , Greece.
authors: N
authors: N
authors: Vlachadis
authors: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynaecology , National and Kapodistrian University of Athens, Aretaieio Hospital , Athens , Greece.
authors: V
authors: V
authors: Tsamadias
authors: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynaecology , National and Kapodistrian University of Athens, Aretaieio Hospital , Athens , Greece.
authors: E
authors: E
authors: Kouskouni
authors: b Second Department of Obstetrics and Gynaecology , National and Kapodistrian University of Athens, Aretaieio Hospital , Athens , Greece.
authors: N
authors: N
authors: Vitoratos
authors: c Obstetrician Gynaecologist, Private Practice , Kalamata , Greece.
authors: K
authors: K
authors: Hatziveis
authors: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynaecology , National and Kapodistrian University of Athens, Aretaieio Hospital , Athens , Greece.
authors: E
authors: E
authors: Economou
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D039661:Integrin beta3 / Q000235:genetics*; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D017211:Treatment Failure
chemical_list: D039421:Integrin alpha2; D039661:Integrin beta3
keywords: GpIIIa; GpIa; IVF; implantation; polymorphisms