title: Bone impairment in primary hyperoxaluria: a review.
abstract: Deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria (PH). Since the bone compartment can store massive amounts of oxalate, patients present with recurrent low-trauma fractures, bone deformations, severe bone pains, and specific oxalate osteopathy on X-ray. Bone biopsy from the iliac crest displays specific features such as oxalate crystals surrounded by a granulomatous reaction corresponding to an invasion of bone surface by macrophages. The objective of this manuscript is therefore to provide an overview of bone impairment in PH, by reviewing the current literature on bone and dental symptoms as well as imaging techniques used for assessing bone disease.
authors: Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 69500, Bron, France. j.bacchetta@laposte.net.|INSERM, UMR 1033, 69008, Lyon, France. j.bacchetta@laposte.net.|Université de Lyon, 69008, Lyon, France. j.bacchetta@laposte.net.|Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Boulevard Pinel, 69677, Bron cedex, France. j.bacchetta@laposte.net.
authors: Justine
authors: J
authors: Bacchetta
authors: INSERM, UMR 1033, 69008, Lyon, France.|Université de Lyon, 69008, Lyon, France.
authors: Georges
authors: G
authors: Boivin
authors: Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 69500, Bron, France.|Université de Lyon, 69008, Lyon, France.
authors: Pierre
authors: P
authors: Cochat
mesh_terms: D000818:Animals; D001706:Biopsy; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002129:Calcium Oxalate / Q000378:metabolism*; D003460:Crystallization; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D009057:Stomatognathic Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
chemical_list: D002129:Calcium Oxalate
keywords: Bone biopsy; Bone density; Bone imaging; Pediatrics; Primary hyperoxaluria
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