title: Multicenter cooperative case survey of hepatitis B virus reactivation by chemotherapeutic agents.
abstract: OBJECTIVE
  The purpose of this multicenter cooperative study was to elucidate the clinical features of hepatitis B virus (HBV) reactivation by chemotherapeutic agents and the patient outcomes after HBV reactivation by a retrospective review of accumulated patients' medical records.
  
  
  METHODS
  Records of a total of 27 patients (hematological malignancy, 14 patients; solid tumor, 13 patients) from 11 institutions who were diagnosed between June 2005 and October 2010 as having HBV reactivation following chemotherapy were reviewed.
  
  
  RESULTS
  Of the 27 patients with reactivation, 16 patients were hepatitis B surface antigen (HBsAg) positive and 11 were HBsAg negative prior to the commencement of chemotherapy. Of the 11 patients who were HBsAg negative prior to the chemotherapy, 10 had hematological malignancies and one had a solid tumor. Of the 14 patients with hematological malignancies with HBV reactivation enrolled in the study, the reactivation occurred more than 12 months after the completion of chemotherapy in five patients (36%); on the other hand, none of the patients (0%) with solid tumors developed HBV reactivation more than 12 months after the completion of chemotherapy. Of the 24 patients who had acute liver dysfunction at the diagnosis of HBV reactivation, nine (38%) had severe hepatitis and seven (29%) died of liver failure.
  
  
  CONCLUSIONS
  Most of the patients with HBV reactivation who were HBsAg negative prior to the chemotherapy had underlying hematological malignancies. Furthermore, patients with hematological malignancies often developed late-onset HBV reactivation. The prognosis of patients who develop acute liver dysfunction as a complication of HBV reactivation is extremely dismal.
authors: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa.
authors: Hideaki
authors: H
authors: Takahashi
authors: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa.
authors: Masafumi
authors: M
authors: Ikeda
authors: Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki.
authors: Takashi
authors: T
authors: Kumada
authors: Departments of Gastroenterology and Hepatology, Osaka Red Cross Hospital.
authors: Yukio
authors: Y
authors: Osaki
authors: Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors: Shunsuke
authors: S
authors: Kondo
authors: Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka.
authors: Shigeru
authors: S
authors: Kusumoto
authors: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital.
authors: Kazuyoshi
authors: K
authors: Ohkawa
authors: Department of Internal Medicine, Medical Oncology, Kyorin University School of Medicine.
authors: Seijin
authors: S
authors: Nadano
authors: Division of Medical Oncology and Hematology, Cancer Institute Hospital.
authors: Junji
authors: J
authors: Furuse
authors: Multi-institutional Clinical Trial Support Center, National Cancer Center, Tokyo.
authors: Masatoshi
authors: M
authors: Kudo
authors: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya.|Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama.
authors: Kiyoaki
authors: K
authors: Ito
authors: The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa.
authors: Masahiro
authors: M
authors: Yokoyama
authors: Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors: Takuji
authors: T
authors: Okusaka
authors: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors: Masanori
authors: M
authors: Shimoyama
authors: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya.
authors: Masashi
authors: M
authors: Mizokami
keywords: case survey; chemotherapy; hepatitis B virus; hepatitis B virus DNA; reactivation