title: Facile preparation and bifunctional imaging of Eu-doped GdPO4 nanorods with MRI and cellular luminescence.
abstract: The biocompatibility of multifunctional nanomaterials is very important for their clinical applications. Herein, the hexagonal crystal Eu-doped GdPO4 nanorods (NRs) in the template of silk fibroin (SF) peptides are successfully synthesized via a mineralization process. The sizes of the Eu-doped GdPO4 NRs with SF peptides (SF-NRs) are ∼150 nm in length and ∼10 nm in diameter. The Eu-doped SF-NRs have strong pink luminescence and a mass magnetic susceptibility value of 1.27 emu g(-1) in 20,000 G of magnetic field due to Eu ion doping. The cell test indicates that the Eu-doped SF-NRs obviously promote the viability of cells at an NR concentration of 25-200 μg mL(-1). A growth mechanism of Eu-doped GdPO4 SF-NRs is proposed to explain their strong cellular luminescence, magnetic resonance (MR) imaging and good cyto-compatibility. Compared to NRs without SF, the Eu-doped SF-NRs not only exhibit a higher effective positive signal-enhancement ability (the longitudinal relaxivity r1 value is 1.38 (Gd mM s)(-1)) and in vivo T1 weighted MR imaging enhancement under a 7.0 T MRI system, but also show the better luminescence imaging of living cells under the fluorescence microscope. This indicates that the Eu-doped SF-NRs have potential as T1 MRI contrast agents and optical imaging probes.
authors: College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China. zbhuang@scu.edu.cn.
authors: Qijun
authors: Q
authors: Du
authors: Zhongbing
authors: Z
authors: Huang
authors: Zhi
authors: Z
authors: Wu
authors: Xianwei
authors: X
authors: Meng
authors: Guangfu
authors: G
authors: Yin
authors: Fabao
authors: F
authors: Gao
authors: Lei
authors: L
authors: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D005063:Europium / Q000737:chemistry* / Q000494:pharmacology; D005349:Fibroins / Q000737:chemistry* / Q000494:pharmacology; D005682:Gadolinium / Q000737:chemistry* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D010455:Peptides; D010710:Phosphates; D005063:Europium; D005349:Fibroins; D005682:Gadolinium