title: The importance of GLP-1 and PYY in resistant starch's effect on body fat in mice.
abstract: Resistant starch (RS) is a dietary fermentable fiber that decreases body fat accumulation, and stimulates the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in rodents. GLP-1 and PYY are gut-secreted hormones with antiobesity effect. Thus, blocking the signals of increased GLP-1 and PYY may also block the effect of dietary RS on body fat. In a 10-week study, C57BL/6J and GLP-1 receptor null (GLP-1R KO) mice were fed control or 30% RS diet, and received daily intraperitoneal injection of either saline or PYY receptor antagonist (BIIE0246, 20 μg/kg body weight). Dietary RS significantly decreased body fat accumulation only in wild-type mice that has saline injection, but not in GLP-1R KO mice. PYY receptor antagonist diminished RS action on body fat in wild-type mice, but did not interfere with GLP-1R KO mice response to RS. Regardless of genotype and injection received, all RS-fed mice had increased cumulative food intake, cecal fermentation, and mRNA expression of proglucagon and PYY. Thus, our results suggest that increased GLP-1 and PYY is important in RS effects on body fat accumulation.
authors: Pennington Biomedical Research Center, Baton Rouge, LA, USA; Veterans Affairs Medical Center, Washington, DC, USA.
authors: June
authors: J
authors: Zhou
authors: Roy J
authors: RJ
authors: Martin
authors: Anne M
authors: AM
authors: Raggio
authors: Li
authors: L
authors: Shen
authors: Kathleen
authors: K
authors: McCutcheon
authors: Michael J
authors: MJ
authors: Keenan
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004043:Dietary Fiber / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1 / Q000097:blood / Q000502:physiology*; D051379:Mice; D019894:Peptide YY / Q000097:blood / Q000502:physiology*; D013213:Starch / Q000494:pharmacology*
chemical_list: D004043:Dietary Fiber; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1; D013213:Starch
keywords: Antagonist; Dietary Fiber; GLP-1 receptor; Obesity; PYY receptor
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