title: Combination Approach: the Future of the War Against Cancer.
abstract: Cancer remains one of the major health problems worldwide and is responsible for one in eight deaths. The worldwide research against cancer as well as genome wide association studies was successful in indentifying the loci associated with cancer but still a substantial amount of casualty remains unexplained. The reason being the cancer cell rapidly develops resistance against the chemotherapeutic or chemopreventive agent in use. Over the last decade, the thorough understanding of molecular and biochemical mechanisms of the carcinogenesis process lead to the rationale of combining anti-cancer agents (therapeutic as well as chemopreventive) to target multiple pathways. Scientists, the world over trying various combinations of chemotherapy, radiation therapy, chemopreventive agents, nanoparticles, etc., in order to specifically as well as efficiently target cancer cells. The present review article summarizes the recent advances in the combination approach against cancer in order to enhance efficacy of treatment with minimal side effects.
authors: The First Affiliated Hospital of Yangtze University, No. 8, Hangkong Road, Jingzhou, Hubei, People's Republic of China.
authors: Lan
authors: L
authors: Chen
authors: Department of Biophysics, Post Graduate Institute of Medical Education and Research, Room No. 525, Research Block B, Chandigarh, 160012, India. anshoo.malhotra@gmail.com.
authors: Anshoo
authors: A
authors: Malhotra
mesh_terms: D000818:Animals; D018890:Chemoprevention / Q000379:methods*; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D050997:Nanomedicine / Q000379:methods; D009369:Neoplasms / Q000517:prevention & control / Q000628:therapy*
keywords: Cancer; Combination approach; Nanoparticles; Phytochemicals