title: Peripapillary choroidal thickness in young Asians with high myopia.
abstract: OBJECTIVE
  To describe the topography and predictors of peripapillary choroidal thickness (PPCT) in highly myopic eyes of young, healthy, Asian subjects.
  
  
  METHODS
  A total of 870 young male subjects aged 21.63 ± 1.15 years were recruited from the Singapore military. Choroidal imaging was performed using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness was manually measured at eight locations around the optic disc.
  
  
  RESULTS
  We analyzed 448 subjects with high myopia (defined as spherical equivalent [SE] worse than -6.0 diopters [D]) and 116 with emmetropia (SE > -0.5 and < 0.5 D). The mean SE was -8.52 ± 1.20 D for the high-myopic group, and 0.11 ± 0.24 D for the emmetropic group. The mean peripapillary choroid was significantly thinner (142.62 ± 43.84 μm) in high myopes compared with emmetropes (181.90 ± 46.43 μm, P < 0.001). Likewise, PPCT showed further decrease with increase in degree of myopic refractive error. Distribution of PPCT showed a markedly different pattern in high-myopic eyes (thickest superiorly) and emmetropic eyes (thickest temporally). However, peripapillary choroid in both the groups was thinnest at the inferior location. Among the ocular factors studied, axial length, IOP, presence of posterior staphyloma, and chorioretinal atrophy were the factors significantly associated with PPCT.
  
  
  CONCLUSIONS
  Highly myopic eyes have significantly thinner peripapillary choroid and showed different distribution of thickness, compared with emmetropes. Axial length, IOP, and presence of posterior staphyloma and chorioretinal atrophy significantly influence PPCT and should be taken into consideration during clinical interpretation of PPCT measurement.
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
authors: Preeti
authors: P
authors: Gupta
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
authors: Carol Y
authors: CY
authors: Cheung
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
authors: Seang-Mei
authors: SM
authors: Saw
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
authors: Mayuri
authors: M
authors: Bhargava
authors: National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore Fundus Image Reading Center, National Healthcare Group Eye Institute, Singapore.
authors: Colin S
authors: CS
authors: Tan
authors: DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore.
authors: Mellisa
authors: M
authors: Tan
authors: DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore.
authors: Adeline
authors: A
authors: Yang
authors: DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore.
authors: Frederick
authors: F
authors: Tey
authors: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore Vision Performance Centre, Military Medical Institute, Singapore Armed Forces, Singapore.
authors: Gerard
authors: G
authors: Nah
authors: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore Vision Performance Centre, Military Medical Institute, Singapore Armed Forces, Singapore.
authors: Paul
authors: P
authors: Zhao
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
authors: Tien Yin
authors: TY
authors: Wong
authors: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
authors: Ching-Yu
authors: CY
authors: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002829:Choroid / Q000473:pathology*; D003317:Corneal Dystrophies, Hereditary / Q000208:ethnology / Q000473:pathology; D058453:Emmetropia / Q000502:physiology; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D009216:Myopia / Q000208:ethnology* / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D015594:Optic Disk Drusen / Q000208:ethnology / Q000473:pathology; D061848:Optical Imaging; D012016:Reference Values; D012029:Refraction, Ocular / Q000502:physiology; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult
keywords: myopia; peripapillary choroidal thickness; spectral-domain optical coherence tomography