title: Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain.
abstract: We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype.
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Rae-Hyung
authors: 0000-0003-3768-0399
authors: RH
authors: Kim
authors: Clinical Research Center of the Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
authors: Jia-Qi
authors: 0000-0002-5480-355X
authors: JQ
authors: Chu
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Jeong-Nam
authors: 0000-0002-7070-1131
authors: JN
authors: Park
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Seo-Yong
authors: 0000-0001-9596-6075
authors: SY
authors: Lee
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Yeo-Joo
authors: 0000-0002-7037-7300
authors: YJ
authors: Lee
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Mi-Kyeong
authors: 0000-0002-9714-4232
authors: MK
authors: Ko
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Ji-Hyeon
authors: 0000-0002-2662-9064
authors: JH
authors: Hwang
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Kwang-Nyeong
authors: 0000-0002-8267-3983
authors: KN
authors: Lee
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Su-Mi
authors: 0000-0002-9242-2731
authors: SM
authors: Kim
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Dongseob
authors: 0000-0001-7499-4253
authors: D
authors: Tark
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Young-Joon
authors: 0000-0002-3436-8175
authors: YJ
authors: Ko
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Hyang-Sim
authors: 0000-0002-3393-8295
authors: HS
authors: Lee
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Min-Goo
authors: 0000-0003-1752-5105
authors: MG
authors: Seo
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Min-Eun
authors: 0000-0003-0559-0997
authors: ME
authors: Park
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Byounghan
authors: 0000-0002-7252-7763
authors: B
authors: Kim
authors: Animal and Plant Quarantine Agency, Anyang, Korea.
authors: Jong-Hyeon
authors: 0000-0003-0824-8121
authors: JH
authors: Park
keywords: Foot-and-mouth disease; Molecular cloning; Vaccine
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