title: Evidence for distinct effects of exercise in different cardiac hypertrophic disorders.
abstract: Aerobic exercise training (AET) attenuates or reverses pathological cardiac remodeling after insults such as chronic hypertension and myocardial infarction. The phenotype of the pathologically hypertrophied heart depends on the insult; therefore, it is likely that distinct types of pathological hypertrophy require different exercise regimens. However, the mechanisms by which AET improves the structure and function of the pathologically hypertrophied heart are not well understood, and exercise research uses highly inconsistent exercise regimens in diverse patient populations. There is a clear need for systematic research to identify precise exercise prescriptions for different conditions of pathological hypertrophy. Therefore, this review synthesizes existing evidence for the distinct mechanisms by which AET benefits the heart in different pathological hypertrophy conditions, suggests strategic exercise prescriptions for these conditions, and highlights areas for future research.
authors: Graduate Program in Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA.
authors: Emily J
authors: EJ
authors: Johnson
authors: Graduate Program in Movement Sciences, College of Education, University of Idaho, Moscow, ID, USA; Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA.
authors: Brad P
authors: BP
authors: Dieter
authors: Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA. Electronic address: susan.marsh@wsu.edu.
authors: Susan A
authors: SA
authors: Marsh
mesh_terms: D006332:Cardiomegaly / Q000503:physiopathology / Q000628:therapy*; D058065:Diabetic Cardiomyopathies / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: Aerobic exercise; Cardiac hypertrophy; Diabetic cardiomyopathy; Exercise prescription; Myocardial infarction; Pathological hypertrophy; Physiological hypertrophy
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