title: Self-reported sleep duration is associated with reduced glomerular filtration rate among adults with hypertension: a population-based study from rural northeast China.
abstract: Short sleep duration has been found recently to be a predictor of proteinuria. However, population-based investigations addressing the association between self-reported sleep duration and glomerular filtration rate (GFR) among hypertensive patients are lacking. We therefore sought to investigate the extent to which self-reported sleep duration might be associated with reduced GFR in a large hypertensive population in rural northeast China. A total of 5555 hypertensive participants, aged ≥35 years, in rural areas of Liaoning Province, China, were screened between January 2012 and August 2013, using a stratified, cluster multi-stage sampling scheme. Anthropometric measurements, self-reported sleep duration, blood biochemical indexes and other health-related variables were collected by medically trained personnel. Reduced GFR was defined as the estimated GFR (eGFR) < 60 mL min(-1) 1.73 m(2). On average, participants slept for 6.9 ± 1.6 h per night. Mean self-reported sleep duration decreased with eGFR (P < 0.001). For both genders, a lower prevalence of reduced GFR was observed among participants who slept ≤6 h per night in total. In the multivariable regression model, after adjustments for age, gender, ethnicity, lifestyle factors, clinical correlates, depressive symptoms and general quality of life, participants who slept for 6 h or less per night were associated with a higher risk of reduced GFR [odds ratio (OR: 1.70, 95% confidence interval (CI): 1.05-2.73] compared with the reference group (self-reported sleep duration >7 and ≤8 h day(-1) ). We concluded that short self-reported sleep duration (≤6 h per night) was related significantly to an increased risk of reduced GFR in a hypertensive population. This novel risk factor should be taken into consideration during daily management of hypertension to prevent chronic kidney disease.
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Xiaofan
authors: X
authors: Guo
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Shasha
authors: S
authors: Yu
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Zhao
authors: Z
authors: Li
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Liang
authors: L
authors: Guo
authors: Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Liqiang
authors: L
authors: Zheng
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Hongmei
authors: H
authors: Yang
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Lu
authors: L
authors: Zou
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Wenyu
authors: W
authors: Hu
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Ying
authors: Y
authors: Zhou
authors: Department of Cardiology, Dongfang Hospital Affiliated to Tongji University, Shanghai, China.
authors: Luoning
authors: L
authors: Zhu
authors: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors: Yonghong
authors: Y
authors: Zhang
authors: Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Yingxian
authors: Y
authors: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011788:Quality of Life; D012307:Risk Factors; D057566:Self Report; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D013997:Time Factors
keywords: chronic kidney disease; general population; glomerular filtration rate; hypertensive; risk factor; sleep duration