title: Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.
abstract: Glycosylation is one of the most predominant forms of cell-surface protein modifications, yet its deregulation in cancer and contribution to tumor microenvironment interactions remain poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver.
authors: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors: Anna
authors: A
authors: Arnal-Estapé
authors: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut. don.nguyen@yale.edu.
authors: Don X
authors: DX
authors: Nguyen
mesh_terms: D000818:Animals; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism*; D012799:Sialyltransferases / Q000378:metabolism*
chemical_list: D037502:Galectin 3; D017351:N-Acetylglucosaminyltransferases; D012799:Sialyltransferases
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