title: Survival and graft-versus-host disease in patients receiving peripheral stem cell compared to bone marrow transplantation from HLA-matched related donor: retrospective analysis of 334 consecutive patients.
abstract: OBJECTIVE
  The objective of this study was to compare the major transplant outcomes between patients receiving hematopoietic stem cell transplantation (HSCT) from bone marrow (BM) or peripheral blood stem cells (PBSC).
  
  
  METHODS
  All consecutive HSCT patients using BM or PBSC from an HLA-matched related donors for haematological malignancies after high intensity conditioning at seven Brazilian transplant centres between January 2008 and December 2009 were retrospectively evaluated.
  
  
  RESULTS
  In the study period, 334 patients were treated in the centres and included in the evaluation. The cumulative incidence of grades II-IV and III-IV acute graft-versus-host disease (GVHD) at one year was 36.7% and 9.7% for BM recipients and 34.4% and 15.1% for PBSC recipients, respectively (not statistically different). The cumulative incidence of chronic GVHD at three years was 53.7% and 79.8% (HR 1.93; 95% CI 1.38-2.69, P < 0.001) for BM and PBSC, respectively. Median overall survival was 2.85 and 2.39 years for BM and PBSC recipients, respectively (HR 1.19; 95% CI, 0.84-1.68, P = 0.34).
  
  
  CONCLUSIONS
  Our results confirm previous findings of increased chronic GVHD incidence in patients receiving PBSC when compared to patients receiving BM as the graft source in HSCT. Acute GVHD incidence, progression-free survival and overall survival were not different between the groups.
authors: Clinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Paulo Vidal
authors: PV
authors: Campregher
authors: Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Nelson
authors: N
authors: Hamerschlak
authors: Fundação Dr. Amaral Carvalho, Jaú, Brazil.
authors: Vergilio Antonio Renzi
authors: VA
authors: Colturato
authors: Clínica Segalla, Fundação Dr. Amaral Carvalho, Jaú, Brazil.
authors: Marcos Augusto
authors: MA
authors: Mauad
authors: Hospital Amaral Carvalho, Jaú, Brazil.
authors: Mair Pedro
authors: MP
authors: de Souza
authors: Centro de Transplante de Medula Óssea (CEMO), Rio de Janeiro, Brazil.
authors: Luis Fernando da Silva
authors: LF
authors: Bouzas
authors: Centro de Transplante de Medula Óssea (CEMO), Rio de Janeiro, Brazil.
authors: Rita de Cássia B
authors: Rde C
authors: Tavares
authors: Hematology and Oncology, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FMSCSP), São Paulo, Brazil.
authors: José Carlos
authors: JC
authors: Barros
authors: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FMSCSP), São Paulo, Brazil.
authors: Ricardo
authors: R
authors: Chiattone
authors: Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors: Alessandra
authors: A
authors: Paz
authors: Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors: Lucia
authors: L
authors: Silla
authors: Hematology and Hemotherapy Center, Universidade Estadual de Campinas (UNICAMP), INCT do Sangue, Campinas, Brazil.
authors: Afonso Celso
authors: AC
authors: Vigorito
authors: Hematology and Hemotherapy Center, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
authors: Eliane
authors: E
authors: Miranda
authors: Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
authors: Vaneuza Araújo Moreira
authors: VA
authors: Funke
authors: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors: Mary Evelyn
authors: ME
authors: Flowers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology / Q000401:mortality*; D019337:Hematologic Neoplasms / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors
keywords: haematological neoplasms; hematopoietic stem cell transplantation; multicenter study; peripheral blood stem cell transplantation