title: Bifunctionalized mesoporous silica-supported gold nanoparticles: intrinsic oxidase and peroxidase catalytic activities for antibacterial applications.
abstract: Bifunctionalized mesoporous silica-supported gold nanoparticles as oxidase and peroxidase mimics for antibacterial applications are demonstrated. For the first time, these mesoporous silica-supported gold nanoparticles are applied as oxidase and peroxidase mimics. Taking advantage of their prominent enzyme activities, the MSN-AuNPs show excellent antibacterial properties against both Gram-negative and Gram-positive bacteria. Furthermore, MSN-AuNPs also exhibit outstanding performance in biofilm elimination .
authors: State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, 130022, China; Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, 130022, China.
authors: Yu
authors: Y
authors: Tao
authors: Enguo
authors: E
authors: Ju
authors: Jinsong
authors: J
authors: Ren
authors: Xiaogang
authors: X
authors: Qu
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D040761:Biomimetic Materials / Q000138:chemical synthesis; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D004789:Enzyme Activation; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D010088:Oxidoreductases / Q000737:chemistry*; D009195:Peroxidase / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D006046:Gold; D012822:Silicon Dioxide; D010088:Oxidoreductases; D009195:Peroxidase
keywords: antibacterial agents; bifunctionalization; gold nanoparticles; mesoporous silica; oxidase and peroxidase catalytic activities