title: Vitamin-E diffused highly cross-linked polyethylene liner compared to standard liners in total hip arthroplasty. A randomized, controlled trial.
abstract: OBJECTIVE
  We hypothesized that a vitamin E-treated polyethylene articulating liner had lower femoral head penetration than a conventional liner.
  
  
  METHODS
  Fifty-one patients with primary hip osteoarthritis were randomized to an uncemented cup with either vitamin E-treated highly cross-linked polyethylene (HXLPE) (vitamin-e group, n = 25) or a standard HXLPE liner (control group, n = 26) and followed for two years after surgery. The outcome variable was polyethylene (PE) linear head penetration, measured with radiostereometry (RSA).
  
  
  RESULTS
  The head penetration in x- (medial/lateral) and y- (vertical) axes was significantly lower for the vitamin E-treated liner up to two years with a mean difference between the groups of 0.10 mm (95 % CI 0.04-0.18) and 0.08 mm (95 % CI 0.01-0.15), respectively. The initial total penetration was lower for the vitamin-E group but did not reach statistical significance at two years with a mean difference between the groups of 0.07 mm (95 % CI -0.001 to 0.15, p = 0.09). We found no differences in clinical outcome between the groups.
  
  
  CONCLUSIONS
  In this prospective, randomized, controlled trial on a new vitamin-E diffused HXLPE liner we found, compared to a conventional HXLPE liner, lower initial head penetration and lower superior and medial wear. A longer follow-up than two years is necessary to demonstrate lower overall head penetration in vitamin-E liners compared to contemporary highly cross-linked PE.
authors: Division of Orthopaedics, Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
authors: Mats
authors: M
authors: Salemyr
authors: Olle
authors: O
authors: Muren
authors: Torbjörn
authors: T
authors: Ahl
authors: Henrik
authors: H
authors: Bodén
authors: Ghazi
authors: G
authors: Chammout
authors: André
authors: A
authors: Stark
authors: Olof
authors: O
authors: Sköldenberg
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005270:Femur Head / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery; D020959:Polyethylene / Q000737:chemistry; D011446:Prospective Studies; D011475:Prosthesis Failure; D059869:Radiostereometric Analysis; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D020959:Polyethylene
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