title: Synthesis and Structure of a Ternary Copper(II) Complex with Mixed Ligands of Diethylenetriamine and Picrate: DNA/Protein-Binding Property and In Vitro Anticancer Activity Studies.
abstract: Based on the importance of the design and synthesis of transition metal complexes with noncovalent DNA/protein-binding abilities in the field of metallo pharmaceuticals, a new mononuclear ternary copper(II) complex with mixed ligands of diethylenetriamine (dien) and picrate anion (pic), identified as [Cu(dien)(pic)](pic), was synthesized and characterized by elemental analysis, molar conductivity measurement, infrared spectrum, electronic spectral studies, and single-crystal X-ray diffractometry. The structure analysis reveals that the copper(II) complex crystallizes in the monoclinic space group P21 /c, and the copper(II) ion has a distorted square pyramidal coordination geometry. A two-dimensional supramolecular structure is formed through hydrogen bonds. The DNA/bovine serum albumin (BSA)-binding properties of the complex are explored, indicating that the complex can interact with herring sperm DNA via intercalation mode and bind to BSA responsible for quenching of tryptophan fluorescence by static quenching mechanism. The in vitro anticancer activity shows that the copper(II) complex is active against the selected tumor cell lines.
authors: Marine Drug & Food Institute, Ocean University of China, Qingdao, 266003, People's Republic of China. yantuanli@ouc.edu.cn.
authors: Ya-Ning
authors: YN
authors: Shi
authors: Kang
authors: K
authors: Zheng
authors: Ling
authors: L
authors: Zhu
authors: Yan-Tuan
authors: YT
authors: Li
authors: Zhi-Yong
authors: ZY
authors: Wu
authors: Cui-Wei
authors: CW
authors: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D010851:Picrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010851:Picrates; D011073:Polyamines; D012709:Serum Albumin; C005391:diethylenetriamine; D003300:Copper; D004247:DNA; C005858:picric acid
keywords: Anticancer Activity; BSA Interaction; Crystal Structure; DNA Binding; Ternary Copper(II) Complex