title: Transplantation of human amniotic epithelial cells repairs brachial plexus injury: pathological and biomechanical analyses.
abstract: A brachial plexus injury model was established in rabbits by stretching the C6 nerve root. Immediately after the stretching, a suspension of human amniotic epithelial cells was injected into the injured brachial plexus. The results of tensile mechanical testing of the brachial plexus showed that the tensile elastic limit strain, elastic limit stress, maximum stress, and maximum strain of the injured brachial plexuses were significantly increased at 24 weeks after the injection. The treatment clearly improved the pathological morphology of the injured brachial plexus nerve, as seen by hematoxylin eosin staining, and the functions of the rabbit forepaw were restored. These data indicate that the injection of human amniotic epithelial cells contributed to the repair of brachial plexus injury, and that this technique may transform into current clinical treatment strategies.
authors: China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors: Qi
authors: Q
authors: Yang
authors: China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors: Min
authors: M
authors: Luo
authors: Department of Mechanics, School of Mechanical Science and Engineering, Jilin University, Changchun, Jilin Province, China.
authors: Peng
authors: P
authors: Li
authors: China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors: Hai
authors: H
authors: Jin
keywords: animal model; brachial plexus injury; forepaw function; human amniotic epithelial cells; morphology; nerve regeneration; neural regeneration; peripheral nerve injury; tensile mechanics
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