title: Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
abstract: Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Frank J
authors: FJ
authors: Meye
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Kristina
authors: K
authors: Valentinova
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Salvatore
authors: S
authors: Lecca
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Lucile
authors: L
authors: Marion-Poll
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Matthieu J
authors: MJ
authors: Maroteaux
authors: DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
authors: Stefano
authors: S
authors: Musardo
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Imane
authors: I
authors: Moutkine
authors: DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
authors: Fabrizio
authors: F
authors: Gardoni
authors: Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors: Richard L
authors: RL
authors: Huganir
authors: 1] Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] Université de Bordeaux, Bordeaux, France.
authors: François
authors: F
authors: Georges
authors: 1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
authors: Manuel
authors: M
authors: Mameli
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D019262:Habenula / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D019417:Hindlimb Suspension; D066298:In Vitro Techniques; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects; D009154:Mutation / Q000235:genetics; D018408:Patch-Clamp Techniques; D021381:Protein Transport / Q000187:drug effects*; D018091:Receptors, AMPA / Q000235:genetics / Q000378:metabolism*; D013550:Swimming / Q000523:psychology; D000097573:Red Fluorescent Protein
chemical_list: D003042:Cocaine; D018765:Dopamine Uptake Inhibitors; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins; D018091:Receptors, AMPA; D000097573:Red Fluorescent Protein
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