title: Oxidative stress and plasma lipoproteins in cancer patients.
abstract: OBJECTIVE
  To evaluate the relation between oxidative stress and lipid profile in patients with different types of cancer.
  
  
  METHODS
  This was an observational cross-sectional. A total of 58 subjects were evaluated, 33 males, divided into two groups of 29 patients each: Group 1, patients with cancer of the digestive tract and accessory organs; Group 2 patients with other types of cancers, all admitted to a public hospital. The plasma levels (lipoproteins and total cholesterol, HDL, and triglycerides, for example) were analyzed by enzymatic kits, and oxidative stress based on thiobarbituric acid-reactive substances, by assessing the formation of malondialdehyde.
  
  
  RESULTS
  In general the levels of malondialdehyde of patients were high (5.00μM) as compared to 3.31μM for healthy individuals. The median values of lipids exhibited normal triacylglycerol (138.78±89.88mg/dL), desirable total cholesterol values (163.04±172.38mg/dL), borderline high LDL (151.30±178.25mg/dL) and low HDL (31.70±22.74mg/dL). Median HDL levels in Group 1 were lower (31.32mg/dL) than the cancer patients in Group 2 (43.67mg/dL) (p=0.038). Group 1 also showed higher levels of oxidative stress (p=0.027).
  
  
  CONCLUSIONS
  The lipid profile of patients with cancer was not favorable, which seems to have contributed to higher lipid peroxidation rate, generating a significant oxidative stress.
authors: Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
authors: Fernanda Maria Machado
authors: FM
authors: Maia
authors: Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
authors: Emanuelly Barbosa
authors: EB
authors: Santos
authors: Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
authors: Germana Elias
authors: GE
authors: Reis
mesh_terms: D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D009369:Neoplasms / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D012016:Reference Values; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol
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