title: Hematological and iron content evolution in exclusively breastfed late-preterm newborns.
abstract: OBJECTIVE
  To analyze and compare the evolution of hematological parameters and body iron content between exclusively breastfed late-preterm and term newborns during the first two months of life.
  
  
  METHODS
  Cohort study. Weight, length, head circumference, body mass index, hemoglobin, hematocrit, reticulocytes, total iron-binding capacity, transferrin saturation, serum iron and ferritin were measured in 25 late-preterm and 21 term newborns (at birth and at one and two months of age) who were exclusively breastfed.
  
  
  METHODS
  Kolmogorov-Smirnov test, one-way ANOVA or Kruskal-Wallis test; and Student's t-test or Mann-Whitney test.
  
  
  CONCLUSIONS
  p<0.05.
  
  
  RESULTS
  The corrected gestational ages of the late-preterm infants were 39.98 weeks at one month of life and 44.53 weeks at two months. Anthropometric measures and the body mass index increased over time (p<0.001) and hemoglobin, hematocrit, reticulocytes and body iron content decreased (p<0.001). Late-preterm infants at term corrected gestational age had reduced hemoglobin, hematocrit and reticulocyte concentrations, and reduced total iron-binding capacity (p<0.001) and serum iron (p=0.0034) compared with values observed in term newborns at birth. Late-preterm newborns at a corrected gestational age of one month post-term had hemoglobin (p=0.0002), hematocrit (p=0.0008), iron (p<0.0001) and transferrin saturation (p<0.001) levels lower than those of term newborns at one month of age and a higher total iron-binding capacity (p=0.0018). Ferritin did not differ between the groups.
  
  
  CONCLUSIONS
  Exclusively breastfed late-preterm newborns presented greater reductions in hemoglobin/hematocrit and lower iron stores at a corrected gestational age of one month post-term than did term newborns, suggesting specific iron supplementation needs.
authors: Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors: Renato Takeshi
authors: RT
authors: Yamada
authors: Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors: Cléa Rodrigues
authors: CR
authors: Leone
mesh_terms: D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D000886:Anthropometry; D001942:Breast Feeding; D015331:Cohort Studies; D005260:Female; D005293:Ferritins / Q000097:blood; D005865:Gestational Age; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007501:Iron / Q000097:blood*; D008297:Male; D047928:Premature Birth; D012016:Reference Values; D012156:Reticulocytes; D018709:Statistics, Nonparametric; D013997:Time Factors; D061250:Transferrins / Q000378:metabolism; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D061250:Transferrins; D005293:Ferritins; D007501:Iron
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