title: Formulation of Aluminum Chloride Phthalocyanine in Pluronic(™) P-123 and F-127 Block Copolymer Micelles: Photophysical properties and Photodynamic Inactivation of Microorganisms.
abstract: Aluminum Chloride Phthalocyanine (AlPcCl) can be used as a photosensitizer (PS) for Photodynamic Inactivation of Microorganisms (PDI). The AlPcCl showed favorable characteristics for PDI due to high quantum yield of singlet oxygen (ΦΔ ) and photostability. Physicochemical properties and photodynamic inactivation of AlPcCl incorporated in polymeric micelles of tri-block copolymer (P-123 and F-127) against microorganisms Staphylococcus aureus, Escherichia coli and Candida albicans were investigated in this work. Previously, it was observed that the AlPcCl undergoes self-aggregation in F-127, while in P-123 the PS is in a monomeric form suitable for PDI. Due to the self-aggregation of AlPcCl in F-127, this formulation did not show any effect on these microorganisms. On the other hand, AlPcCl formulated in P-123 was effective against S. aureus and C. albicans and the death of microorganisms was dependent on the PS concentration and illumination time. Additionally, it was found that the values of PS concentration and illumination time to eradicate 90% of the initial population of microorganisms (IC90 and D90 , respectively) were small for the AlPcCl in P-123, showing the effectiveness of this formulation for PDI.
authors: Chemistry Department, State University of Maringá, Maringá, Paraná, Brazil.
authors: Bruno Henrique
authors: BH
authors: Vilsinski
authors: Adriana Passarella
authors: AP
authors: Gerola
authors: Junior Adalberto
authors: JA
authors: Enumo
authors: Katieli da Silva Souza
authors: Kda S
authors: Campanholi
authors: Paulo Cesar de Souza
authors: PC
authors: Pereira
authors: Gustavo
authors: G
authors: Braga
authors: Noboru
authors: N
authors: Hioka
authors: Elza
authors: E
authors: Kimura
authors: André Luiz
authors: AL
authors: Tessaro
authors: Wilker
authors: W
authors: Caetano
mesh_terms: D000077410:Aluminum Chloride; D002176:Candida albicans / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry*; D008027:Light; D008823:Micelles; D050296:Microbial Viability / Q000187:drug effects*; D009942:Organometallic Compounds / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000528:radiation effects; D020442:Poloxamer / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000528:radiation effects
chemical_list: C000608703:F-127 compound; D007211:Indoles; D008823:Micelles; D009942:Organometallic Compounds; C000608702:P-123 compound; D017319:Photosensitizing Agents; C000608700:aluminum chloride phthalocyanine; D020442:Poloxamer; D000077410:Aluminum Chloride