title: Microinflammation factors in the common diseases of the heart and kidneys.
abstract: OBJECTIVE
  To determine levels of interleukin-8 (IL-8) and plasminogen activator inhibitor-1 (PAI-1) in different cardiorenal syndrome (CRS) modalities and to compare findings to some already investigated direct and indirect parameters of inflammation and atherosclerosis.
  
  
  METHODS
  Testing involved 114 examinees, divided into control and clinical groups suffering from different modalities and were formed according to the basis of a valid classification for CRS.
  
  
  RESULTS
  C-reactive protein (CRP) was significantly higher in all CRSs in comparison to the control group (P < 0.05). PAI-1 in CRSs was statistically higher than in the control group. IL-8 was increased in all CRSs, and especially in CRS-5, where no significance was found. PAI-1 correlated with IL-8 in all CRSs, with significant value in CRS-2 and CRS-5. Correlation for PAI-1 and high-density lipoproteins (HDL) was found in CRS-4, while IL-8 was found to be related to CRP level in all CRSs, with significance only in CRS-1 (P < 0.001).
  
  
  CONCLUSIONS
  C-reactive protein, IL-8, and PAI-1 could be useful for clinical differentiation of chronic modalities of CRSs. Inflammation was the most pronounced in CRS-4. Lipid status parameters could be useful for differentiation of CRSs. Furthermore, HDL in chronic primary kidney diseases and triglycerides and total cholesterol in CRS-5 could be valuable.
authors: Clinical Centre of Nis, The Clinic of Nephrology, Dr. Zoran Djindjic Boulevard 48, 18000 Nis, Serbia.
authors: Danijela
authors: D
authors: Tasic
authors: Clinical Centre of Nis, The Clinic of Nephrology, Dr. Zoran Djindjic Boulevard 48, 18000 Nis, Serbia ; The University of Nis, Faculty of Medicine, Dr. Zoran Djindjic Boulevard 81, 18000 Nis, Serbia.
authors: Sonja
authors: S
authors: Radenkovic
authors: The University of Nis, Faculty of Medicine, Dr. Zoran Djindjic Boulevard 81, 18000 Nis, Serbia.
authors: Gordana
authors: G
authors: Kocic
authors: The University of Nis, Faculty of Medicine, Dr. Zoran Djindjic Boulevard 81, 18000 Nis, Serbia.
authors: Marina Deljanin
authors: MD
authors: Ilic
authors: The University of Nis, Faculty of Medicine, Dr. Zoran Djindjic Boulevard 81, 18000 Nis, Serbia.
authors: Aleksandra
authors: A
authors: Ignjatovic
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D059347:Cardio-Renal Syndrome / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*
chemical_list: D016209:Interleukin-8; D008075:Lipoproteins, HDL; D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein
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