title: Nebulized antibiotics. An adequate option for treating ventilator-associated respiratory infection?
abstract: Ventilator-associated tracheobronchitis (VAT) is a frequent complication in critical patients. The 90% of those who develop it receive broad-spectrum antibiotic (ATB) treatment, without any strong evidence of its favorable impact. The use of nebulized ATB could be a valid treatment option, to reduce the use of systemic ATB and the pressure of selection on the local flora. Several studies suggest that an adequate nebulization technique can ensure high levels of ATB even in areas of lung consolidation, and to obtain clinical and microbiological cure. New studies are needed to properly assess the impact of treatment with nebulized ATB on the emergence of resistance.
authors: Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), España. Electronic address: ahr1161@yahoo.es.
authors: A
authors: A
authors: Rodríguez
authors: Unidad Funcional de Infección Nosocomial, Hospital Universitario Arnau de Vilanova, Lleida, España.
authors: F
authors: F
authors: Barcenilla
mesh_terms: D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006801:Humans; D009330:Nebulizers and Vaporizers; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibioticos nebulizados; Infección respiratoria; Nebulized antibiotics; Respiratory infections; Tracheobronchitis; Traqueobronquitis