title: Curcumin/cellulose micro crystals/chitosan films: water absorption behavior and in vitro cytotoxicity.
abstract: A new technique, called vapor induced phase inversion (VIPI), has been employed to fabricate cellulose micro crystals (CMC)-loaded chitosan (Ch) films. The method involves immediate exposure of CMC-dispersed chitosan solution to NH3 gas. The films were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) analysis. The swelling ratio (SR) of films showed negative dependence on the cellulose content in the films. The dynamic water uptake data were interpreted by various kinetic models. Finally, the release of curcumin from the films was investigated. The CMC-loaded chitosan film showed slower release as compared to the plain chitosan film, suggesting that cellulose micro crystals acted as diffusion barrier. The films were non-cytotoxic, non-thrombogenic and non-hemolytic.
authors: Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur, MP 482001, India. Electronic address: sunil.mnlbpi@gmail.com.
authors: S K
authors: SK
authors: Bajpai
authors: Advanced Materials Processes and Research Institute, Polymer Composite Group, Bhopal, MP, India.
authors: Navin
authors: N
authors: Chand
authors: Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur, MP 482001, India.
authors: Sonam
authors: S
authors: Ahuja
authors: IIITDM, Jabalpur India.
authors: M K
authors: MK
authors: Roy
mesh_terms: D065966:Absorption, Physicochemical; D000327:Adsorption / Q000187:drug effects; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D002482:Cellulose / Q000737:chemistry* / Q000633:toxicity; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity; D003460:Crystallization; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D006813:Humidity; D007700:Kinetics; D051379:Mice; D018625:Microscopy, Atomic Force; D008962:Models, Theoretical; D010539:Permeability / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D013927:Thrombosis / Q000473:pathology; D018675:Toxicity Tests; D014835:Volatilization; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D002482:Cellulose; D048271:Chitosan; D003474:Curcumin
keywords: Cellulose; Chitosan; Moisture permeation; Phase inversion; Wound dressings