title: 3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides.
abstract: A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesized as a fundamental model for more complex cyclic peptides.
authors: Department of Medicinal Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. yhayashi@toyaku.ac.jp.
authors: Akihiro
authors: A
authors: Taguchi
authors: Kentarou
authors: K
authors: Fukumoto
authors: Yuya
authors: Y
authors: Asahina
authors: Akihiro
authors: A
authors: Kajiyama
authors: Shunsuke
authors: S
authors: Shimura
authors: Keisuke
authors: K
authors: Hamada
authors: Kentaro
authors: K
authors: Takayama
authors: Fumika
authors: F
authors: Yakushiji
authors: Hironobu
authors: H
authors: Hojo
authors: Yoshio
authors: Y
authors: Hayashi
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010456:Peptides, Cyclic; D011725:Pyridines; C065586:3-nitro-2-pyridinesulfenyl