title: Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats.
abstract: New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was 10.06 µm, and the diameter of 89.93% of all microspheres ranged from 7.0 µm to 30.0 µm. Tissue distribution of the microspheres was evaluated along with a conventional enrofloxacin preparation after a single intravenous injection (7.5 mg of enrofloxacin/kg bw). The results showed that the elimination half-life (t1/2β) of enrofloxacin from lung was prolonged from 7.94 h for the conventional enrofloxacin to 13.28 h for the microspheres. Area under the lung concentration versus time curve from 0 h to ∞ (AUC00∞) was increased from 11.66 h·µg/g to 508.00 h·µg/g. The peak concentration (Cmax) in lung was increased from 5.95 µg/g to 93.36 µg/g. Three lung-targeting parameters were further assessed and showed that the microspheres had remarkable lung-targeting capabilities.
authors: Laboratory of Veterinary Pharmacology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
authors: Fan
authors: F
authors: Yang
authors: Jijun
authors: J
authors: Kang
authors: Fang
authors: F
authors: Yang
authors: Zhensheng
authors: Z
authors: Zhao
authors: Tao
authors: T
authors: Kong
authors: Zhenling
authors: Z
authors: Zeng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin
keywords: enrofloxacin; lung-targeting; microsphere; preparation; tissue distribution
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