title: Chemical composition and anti-Helicobacter pylori effect of Satureja bachtiarica Bunge essential oil.
abstract: Resistance of H. pylori strains to common antibiotics has been developed in different parts of the world and continues to increase. It is important to investigate the novel and efficient anti-H. pylori drugs, among which the plants would be suitable sources. Satureja bachtiarica Bunge is traditionally used as antimicrobial agent. In this study, we evaluated the antibacterial activity of S. bachtiarica Bunge essential oil against 10 clinical isolates of Helicobacter pylori by disc diffusion and agar dilution methods. The chemical composition of essential oil was analyzed by GC and GC-MS. Carvacrol (45.5%) and thymol (27.9%) were the primary constituents of oil, followed by p-cymene (4.4%), and γ-terpinene (4.0%). S. bachtiarica essential oil showed strong antibacterial activity against clinical isolates of H. pylori (17.6 ± 1.1 mm and 0.035 ± 0.13 μl/ml). Carvacrol, as the first main component, had a significant role in this effect, whereas in the presence of thymol, the antibacterial effect of carvacrol was reduced. Therefore, S. bachtiarica essential oil can be applied as an alternative agent for treatment of H. pylori infections. More studies would be required to better clarify its mechanism of action on H. pylori.
authors: Department of Biology, Alzahra University, Tehran, Iran.
authors: Tahereh
authors: T
authors: Falsafi
authors: Department of Biology, Alzahra University, Tehran, Iran.
authors: Parisa
authors: P
authors: Moradi
authors: Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran. Electronic address: mahboubi1357@yahoo.com.
authors: Mohaddese
authors: M
authors: Mahboubi
authors: Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
authors: Ebrahim
authors: E
authors: Rahimi
authors: Department of Microbiology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
authors: Hassan
authors: H
authors: Momtaz
authors: Department of Medicinal Plants, Faculty of Agriculture, Islamic Azad University-Shahrekord Branch, Shahrekord, Iran.
authors: Behzhad
authors: B
authors: Hamedi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D008401:Gas Chromatography-Mass Spectrometry; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology; D009822:Oils, Volatile / Q000494:pharmacology*; D031362:Satureja / Q000737:chemistry*; D013943:Thymol / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; C007210:4-cymene; D013943:Thymol; C018669:gamma-terpinene; C073316:carvacrol
keywords: Carvacrol; Helicobacter pylori; Satureja bachtiarica Bunge; Thymol; p-Cymene; γ-Terpinene