title: Effect of preventive use of nonsteroidal anti-inflammatory drugs on sensitivity after dental bleaching: a systematic review and meta-analysis.
abstract: BACKGROUND
  Tooth sensitivity associated with bleaching remains a challenge for clinicians. Inflammatory mediators released by the penetration of bleaching agents into dental tissues can sensitize nociceptors, leading to tooth sensitivity.
  
  
  METHODS
  In this systematic review, the authors included randomized clinical trials in which the investigators compared the preventive use of nonsteroidal anti-inflammatory drugs (NSAIDs) with a placebo for sensitivity after dental bleaching. The authors included only studies in which the investigators evaluated in-office tooth bleaching with high-concentration hydrogen peroxide and reported the risk or the level of tooth sensitivity after bleaching.
  
  
  RESULTS
  The authors included 3 studies and evaluated the levels of sensitivity reported at up to 1 hour after the procedure and from 1 to 24 hours after bleaching. The authors also calculated the pooled relative risk for the effect of preventive use of NSAIDs on sensitivity after dental bleaching. Preventive analgesia with NSAIDs did not have a significant effect on the risk of sensitivity after dental bleaching or on the levels of sensitivity reported by patients.
  
  
  CONCLUSIONS
  There is insufficient evidence about the use of NSAIDs to prevent tooth sensitivity caused by in-office bleaching procedures.
authors: André Luis
authors: AL
authors: Faria-E-Silva
authors: Flávia Pardo Salata
authors: FP
authors: Nahsan
authors: Micaelle Tenório Guedes
authors: MT
authors: Fernandes
authors: Paulo Ricardo Saquete
authors: PR
authors: Martins-Filho
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D014073:Tooth Bleaching / Q000009:adverse effects*; D058205:Tooth Bleaching Agents / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D058205:Tooth Bleaching Agents
keywords: Nonsteroidal anti-inflammatory drugs; drug; prescriptions; sensitivity; tooth; tooth bleaching