title: Evaluation of the effects of quercetin on damaged salivary secretion.
abstract: With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Ayako
authors: A
authors: Takahashi
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan; Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan.
authors: Hiroko
authors: H
authors: Inoue
authors: Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, Japan.
authors: Kenji
authors: K
authors: Mishima
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Fumio
authors: F
authors: Ide
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Ryoko
authors: R
authors: Nakayama
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Ayaka
authors: A
authors: Hasaka
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Koufuchi
authors: K
authors: Ryo
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Yumi
authors: Y
authors: Ito
authors: Department of Radiopraxis Science, Graduate School of Dentistry, Kanagawa Dental University, Yokosuka, Japan.
authors: Takashi
authors: T
authors: Sakurai
authors: Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan.
authors: Yoshinori
authors: Y
authors: Hasegawa
authors: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors: Ichiro
authors: I
authors: Saito
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D053263:Gene Regulatory Networks; D018836:Inflammation Mediators / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D008297:Male; D051379:Mice; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental; D012463:Saliva; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D012472:Salivation / Q000187:drug effects* / Q000235:genetics
chemical_list: D000975:Antioxidants; D016207:Cytokines; D018836:Inflammation Mediators; D011794:Quercetin; D052250:Nitric Oxide Synthase Type III; D002118:Calcium
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