title: Altered Brain Activation in Early Drug-Naive Parkinson's Disease during Heat Pain Stimuli: An fMRI Study.
abstract: Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms. To date, many studies of PD have focused on its cardinal motor symptoms. To study the nonmotor signs of early PD, we investigated the reactions solicited by heat pain stimuli in early untreated PD patients without pain using fMRI. The activation patterns of contact heat stimuli (51°C) were assessed in 14 patients and 17 age- and sex-matched healthy controls. Patients with PD showed significant decreases in activation of the superior temporal gyrus (STG) and insula compared with controls. In addition, a significant relationship between activation of the insula and STG and the pain scores was observed in healthy controls but not in PD. This study provided further support that the insula and STG are important parts of the somatosensory circuitry recruited during the period of pain. The hypoactivity of the STG and insula in PD implied that functions including affective, cognitive, and sensory-discriminative processes, which are associated with the insula and STG, were disturbed. This finding supports the view that leaving early PD untreated could be tied directly to central nervous system dysfunction.
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China ; School of Computer Science and Technology, Southwest University for Nationalities, Chengdu 610041, China.
authors: Ying
authors: Y
authors: Tan
authors: Neurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
authors: Juan
authors: J
authors: Tan
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors: Cheng
authors: 0000-0003-0524-5886
authors: C
authors: Luo
authors: Neurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
authors: Wenjuan
authors: W
authors: Cui
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors: Hui
authors: H
authors: He
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors: Yi
authors: Y
authors: Bin
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors: Jiayan
authors: J
authors: Deng
authors: School of Life and Science Engineering, Southwest Jiaotong University, Chengdu 610031, China.
authors: Rui
authors: R
authors: Tan
authors: School of Computer Science and Technology, Southwest University for Nationalities, Chengdu 610041, China.
authors: Wenrong
authors: W
authors: Tan
authors: School of Computer Science and Technology, Southwest University for Nationalities, Chengdu 610041, China.
authors: Tao
authors: T
authors: Liu
authors: Neurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
authors: Nanlin
authors: N
authors: Zeng
authors: Neurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
authors: Ruhui
authors: R
authors: Xiao
authors: The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors: Dezhong
authors: D
authors: Yao
authors: Neurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
authors: Xiaoming
authors: X
authors: Wang
references: Int J Geriatr Psychiatry. 2013 Aug;28(8):858-67
references: 23124844
references: Pain. 2012 May;153(5):1107-13
references: 22456108
references: Neurobiol Aging. 2014 Jan;35(1):223-31
references: 23932879
references: Mol Pain. 2010 Nov 16;6:80
references: 21080967
references: Pain. 2013 Mar;154(3):459-67
references: 23352757
references: J Pain. 2013 Jul;14(7):663-75
references: 23685185
references: Neuroimage. 2011 Mar 1;55(1):204-15
references: 21126588
references: Mov Disord. 2005 Dec;20(12):1557-63
references: 16078219
references: Hum Brain Mapp. 2013 Jan;34(1):109-49
references: 22131304
references: Lancet Neurol. 2014 Mar;13(3):287-305
references: 24556007
references: Neuroimage. 2011 Mar 15;55(2):462-7
references: 21184830
references: Neural Plast. 2014;2014:180138
references: 25478236
references: Neurosci Lett. 2009 Aug 21;460(1):6-10
references: 19463891
references: Magn Reson Med. 1999 May;41(5):1044-57
references: 10332889
references: Pain. 2011 Apr;152(4):860-5
references: 21316148
references: Arch Neurol. 1999 Jan;56(1):33-9
references: 9923759
references: Ther Adv Neurol Disord. 2014 Jul;7(4):206-20
references: 25002908
references: J Neurol Sci. 2014 Apr 15;339(1-2):189-95
references: 24642509
references: Nat Neurosci. 2000 Feb;3(2):184-90
references: 10649575
references: Parkinsonism Relat Disord. 2013 Mar;19(3):285-94; discussion 285
references: 23246139
references: J Pain Res. 2011;4:365-71
references: 22090805
references: Neuroimage. 2011 Jan 15;54(2):1324-35
references: 20851770
references: Pain. 2014 Aug;155(8):1632-48
references: 24845572
references: PLoS One. 2013;8(1):e54980
references: 23359616
references: Hum Brain Mapp. 2012 Jun;33(6):1279-94
references: 21520351
references: Arthritis Rheum. 2013 Dec;65(12):3293-303
references: 23982850
references: Anesthesiology. 2006 Jul;105(1):120-7
references: 16810003
references: Parkinsonism Relat Disord. 2013 May;19(5):548-52
references: 23462484
references: Neurol Med Chir (Tokyo). 2009 Nov;49(11):507-13
references: 19940398
references: Neurobiol Aging. 2014 Feb;35(2):431-41
references: 24074808
references: Epilepsy Res. 2010 Oct;91(2-3):133-42
references: 20674274
references: Mov Disord. 2010 Jul 15;25(9):1195-202
references: 20629160
references: Brain. 2014 Aug;137(Pt 8):2143-54
references: 24736308