title: [Drug-food interactions in internal medicine: What physicians should know?].
abstract: Orally administered medications may interact with various fruits, vegetables, herbal medicines, functional foods or dietary supplements. Drug-food interactions, which are mostly unknown from prescribers, including internists, may be responsible for changes in drug plasma concentrations, which may decrease efficacy or led to sometimes life-threatening toxicity. Aging, concomitant medications, transplant recipients, patients with cancer, malnutrition, HIV infection and those receiving enteral or parenteral feeding are at increased risk of drug-food interactions. This review focused on the most clinically relevant drug-food interactions, including those with grapefruit juice, Saint-John's Wort, enteral or parenteral nutrition, their respective consequences in the clinical setting in order to provide thoughtful information for internists in their routine clinical practice. Specific clinical settings are also detailed, such as the Ramadan or multiple medications especially in elderly patients. Drug-food interactions are also presented with respect to the main therapeutic families, including the non-steroidal anti-inflammatory drugs, analgesics, cardiovascular medications, warfarin as well as new oral anticoagulants, anticancer drugs and immunosuppressant medications. Considerable effort has been achieved to a better understanding of food-drug interactions and increase clinicians' ability to anticipate their occurrence and consequences in clinical practice. Describing the frequency of relevant food-drug interactions in internal medicine is paramount in order to optimize patient care and drug dosing on an individual basis as well as to increase patients and doctors information.
authors: Faculté de médecine Paris-Diderot, UMR-S1144, 10, avenue de Verdun, 75010 Paris, France; Service de médecine interne A, clinique thérapeutique, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address: stephane.mouly@lrb.aphp.fr.
authors: S
authors: S
authors: Mouly
authors: Service de médecine interne A, clinique thérapeutique, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
authors: M
authors: M
authors: Morgand
authors: Service de médecine interne A, clinique thérapeutique, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
authors: A
authors: A
authors: Lopes
authors: Faculté de médecine Paris-Diderot, UMR-S1144, 10, avenue de Verdun, 75010 Paris, France; Service de médecine interne A, clinique thérapeutique, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
authors: C
authors: C
authors: Lloret-Linares
authors: Faculté de médecine Paris-Diderot, UMR-S1144, 10, avenue de Verdun, 75010 Paris, France; Service de médecine interne A, clinique thérapeutique, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
authors: J-F
authors: JF
authors: Bergmann
mesh_terms: D001628:Beverages; D019587:Dietary Supplements; D018565:Food-Drug Interactions; D005638:Fruit; D006801:Humans; D007388:Internal Medicine; D007413:Intestinal Mucosa / Q000378:metabolism; D014675:Vegetables; D014815:Vitamins
chemical_list: D014815:Vitamins
keywords: Cytochrome P450 3A4; Drug–food interactions; Grapefruit juice; Herbal medicines; Interactions médicament–aliment; Jus de pamplemousse; P-glycoprotein; P-glycoprotéine; Plantes médicinales