title: Neural Aspects of Inhibition Following Emotional Primes in Depressed Adolescents.
abstract: Adults diagnosed with major depressive disorder (MDD) have been found to be characterized by selective attention to negative material and by impairments in their ability to disengage from, or inhibit the processing of, negative stimuli. Altered functioning in the frontal executive control network has been posited to underlie these deficits in cognitive functioning. We know little, however, about the neural underpinnings of inhibitory difficulties in depressed adolescents. We used functional magnetic resonance imaging in 18 adolescents diagnosed with MDD and 15 age- and gender-matched healthy controls (CTLs) while they performed a modified affective Go/No-Go task that was designed to measure inhibitory control in the presence of an emotional distractor. Participants were presented with either a happy or a sad face, followed by a go or a no-go target to which they either made or inhibited a motor response. A group (MDD, CTL) by valence (happy, sad) by condition (go, no-go) analysis of variance indicated that MDD adolescents showed attenuated BOLD response in the right dorsolateral prefrontal cortex (DLPFC) and in the occipital cortex bilaterally, to no-go targets that followed a sad, but not a happy, face. Adolescents diagnosed with MDD showed anomalous recruitment of prefrontal control regions during inhibition trials, suggesting depression-associated disruption in neural underpinnings of the inhibition of emotional distractors. Given that the DLPFC is associated with the maintenance of goal-relevant information, it is likely that sad faces differentially capture attention in adolescents with MDD and interfere with task demands requiring inhibition.
authors: a Department of Psychology , Stanford University.
authors: Natalie L
authors: NL
authors: Colich
authors: a Department of Psychology , Stanford University.
authors: Lara C
authors: LC
authors: Foland-Ross
authors: a Department of Psychology , Stanford University.
authors: Caitlin
authors: C
authors: Eggleston
authors: b Department of Psychiatry and Behavioral Sciences , Stanford University.
authors: Manpreet K
authors: MK
authors: Singh
authors: a Department of Psychology , Stanford University.
authors: Ian H
authors: IH
authors: Gotlib
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology*; D004644:Emotions / Q000502:physiology; D056344:Executive Function; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation / Q000379:methods*; D017397:Prefrontal Cortex / Q000503:physiopathology*
references: Child Dev. 2004 Sep-Oct;75(5):1357-72
references: 15369519
references: Am J Psychiatry. 2008 Jan;165(1):90-8
references: 17986682
references: Neuroimage. 2002 Oct;17(2):825-41
references: 12377157
references: Annu Rev Clin Psychol. 2010;6:285-312
references: 20192795
references: Front Psychol. 2011 Mar 16;2:39
references: 21716604
references: Biol Psychiatry. 2007 Jan 15;61(2):198-209
references: 17027931
references: Am J Psychiatry. 2005 Nov;162(11):2171-3
references: 16263859
references: J Child Psychol Psychiatry. 2005 Sep;46(9):995-1005
references: 16109002
references: Schizophr Res. 2006 Jul;85(1-3):58-72
references: 16632333
references: J Abnorm Psychol. 2004 Feb;113(1):121-35
references: 14992665
references: J Cogn Neurosci. 1997 Nov;9(6):835-47
references: 23964603
references: J Child Psychol Psychiatry. 2009 Mar;50(3):307-16
references: 19175815
references: Neuroimage. 2008 Jun;41(2):286-301
references: 18407525
references: Neuroimage. 2004 Oct;23(2):483-99
references: 15488398
references: Nat Neurosci. 2005 Jun;8(6):720-2
references: 15880106
references: J Child Psychol Psychiatry. 2006 Nov;47(11):1107-15
references: 17076749
references: J Pers Soc Psychol. 1984 Aug;47(2):427-39
references: 6481620
references: Arch Dis Child. 1969 Jun;44(235):291-303
references: 5785179
references: Behav Brain Res. 2013 Nov 1;256:529-36
references: 23756137
references: Biol Psychiatry. 2008 May 15;63(10):927-34
references: 18452757
references: J Cogn Neurosci. 2002 Nov 15;14(8):1215-29
references: 12495527
references: Psychiatry Res. 2008 Jul 15;163(2):143-55
references: 18455373
references: J Adolesc. 2012 Feb;35(1):11-20
references: 21782233
references: Psychopharmacol Bull. 1985;21(4):995-8
references: 4089116
references: Med Image Anal. 2001 Jun;5(2):143-56
references: 11516708
references: Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1663-8
references: 9990081
references: Annu Rev Neurosci. 2001;24:167-202
references: 11283309
references: Child Dev. 2013 Nov-Dec;84(6):1954-66
references: 23506340
references: J Am Acad Child Adolesc Psychiatry. 2011 Jun;50(6):602-611.e3
references: 21621144
references: Am J Psychiatry. 2006 Jun;163(6):1044-51
references: 16741205
references: J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
references: 9204677
references: Biol Psychiatry. 2006 May 15;59(10):958-65
references: 16458263
references: J Affect Disord. 2006 Jul;93(1-3):149-57
references: 16647141
references: Arch Dis Child. 1970 Feb;45(239):13-23
references: 5440182
references: Arch Gen Psychiatry. 2002 Jul;59(7):597-604
references: 12090812
references: Emotion. 2013 Feb;13(1):92-103
references: 22906084
references: Psychol Sci. 2006 Jun;17(6):478-84
references: 16771797
references: Psychiatry Res. 2010 Jan 30;181(1):30-5
references: 19962859
references: Neuroimage. 2003 Oct;20(2):1052-63
references: 14568475
references: Neuroreport. 2000 Jan 17;11(1):43-8
references: 10683827
references: Psychol Med. 1999 Nov;29(6):1307-21
references: 10616937
references: Biol Psychiatry. 2001 Jun 15;49(12):1002-14
references: 11430842
references: J Neuropsychiatry Clin Neurosci. 1997 Summer;9(3):471-81
references: 9276848
references: J Cogn Neurosci. 2011 Sep;23(9):2123-34
references: 20809855
references: Am J Psychiatry. 2005 Jun;162(6):1067-75
references: 15930054
references: Trends Cogn Sci. 2000 Jun;4(6):223-233
references: 10827445
references: Neuroimage. 2004 Apr;21(4):1732-47
references: 15050594
references: Cogn Emot. 2010 Feb 1;24(2):281-98
references: 20300538
references: Neuroimage. 2001 Dec;14(6):1370-86
references: 11707093
references: J Abnorm Psychol. 2007 Feb;116(1):135-43
references: 17324024
references: Trends Cogn Sci. 2011 Oct;15(10):453-9
references: 21889391
references: Behav Brain Res. 2009 Aug 12;201(2):239-43
references: 19428640