title: Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles.
abstract: Enzyme and voltage stimuli are more biologically compatible in the field of stimuli-responsive systems and release systems based on β-cyclodextrin (CD) and ferrocene (Fc) have attracted much attention. Herein, mesoporous silica nanoparticles (MSNs) have been functionalized with the ferrocenyl moiety (Fc) which interacts with β-cyclodextrin (β-CD) to form an inclusion complex on the opening of the pores. The size of the inclusion complex results in a barrier to the opening of the pores. Based on these characteristics, MSNs with nanovalves have been developed as a release system. The release system shows a clear response to heme protein (horseradish peroxidase or hemoglobin) and H2O2, glucose oxidase (GOD) with horseradish peroxidase (HRP) and glucose, or +1.5 V based on an oxidation stimulus mechanism. Modulating the amount of enzyme or the discretion of the voltage makes the release system a controlled one.
authors: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, China. huoqisheng@jlu.edu.cn.
authors: Yu
authors: Y
authors: Xiao
authors: Tao
authors: T
authors: Wang
authors: Yu
authors: Y
authors: Cao
authors: Xue
authors: X
authors: Wang
authors: Ye
authors: Y
authors: Zhang
authors: Yunling
authors: Y
authors: Liu
authors: Qisheng
authors: Q
authors: Huo
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004558:Electric Stimulation; D005296:Ferrous Compounds / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D005949:Glucose Oxidase / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D000075163:Metallocenes; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D006454:Hemoglobins; D000075163:Metallocenes; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase; D006735:Horseradish Peroxidase; D005947:Glucose; C031215:betadex; C004998:ferrocene