title: Genetic basis of type 2 diabetes--recommendations based on meta-analysis.
abstract: OBJECTIVE
  Despite intensive effort to understand the genetic basis of type 2 diabetes, only a few genes responsible for relatively rare monogenic and syndromic subsets of diabetes are known; however, gene(s) responsible for genetic predispositions to common type 2 diabetes are unknown. The current study was obtained a better understanding of the genetic architecture of type 2 diabetes.
  
  
  METHODS
  Comprehensive literature search was performed and the extracted data was analyzed. The proportion of variance explained by validated genetic factors for a range of metabolic quantitative traits was analyzed.
  
  
  RESULTS
  A fully elucidated landscape of type 2 diabetes genetics may well depict perhaps a hundred or more common variants individually with low impact on disease.
  
  
  CONCLUSIONS
  Every individual harbors a combination of different risk alleles and only special compilations of these variants in combination with other genetic and non-genetic components will likely lead to disease.
authors: Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China. shaoyh021206@163.com.
authors: J
authors: J
authors: Li
authors: Y-P
authors: YP
authors: Gong
authors: C-L
authors: CL
authors: Li
authors: Y-H
authors: YH
authors: Lu
authors: Y
authors: Y
authors: Liu
authors: Y-H
authors: YH
authors: Shao
mesh_terms: D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide