title: Enzyme-driven i-motif DNA folding for logic operations and fluorescent biosensing.
abstract: DNA nanodevices capable of "NOR" and "NAND" logic operations were developed using enzymatic reactions to generate an acidic pH gradient and drive the conformation change of cytosine-rich DNA. Due to the high selectivity and sensitivity of the enzymatic reactions in driving DNA logic gates, novel fluorescent biosensors were further designed for enzyme activity assay and glucose sensing.
authors: Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. dqzhang@iccas.ac.cn.
authors: Ming
authors: M
authors: Wang
authors: Guanxin
authors: G
authors: Zhang
authors: Deqing
authors: D
authors: Zhang
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D015374:Biosensing Techniques; D003596:Cytosine / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D005949:Glucose Oxidase / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008128:Logic; D049329:Nanostructures / Q000737:chemistry*; D059372:Nucleotide Motifs; D012235:Rhodamines / Q000737:chemistry; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; C063127:4-(4-dimethylaminophenylazo)benzoic acid; D003596:Cytosine; D004247:DNA; D004124:p-Dimethylaminoazobenzene; D005949:Glucose Oxidase; D000110:Acetylcholinesterase; D005947:Glucose