title: Relationship between hyperuricemia and lipid profiles in US adults.
abstract: BACKGROUND
  Although the link between hyperuricemia and metabolic syndrome had been recognized, the association of the dyslipidemia among individuals with hyperuricemia remains not comprehensively assessed.
  
  
  METHODS
  Using NHANES III study, we examined the relation between serum lipid profiles and different serum uric acid levels, including serum total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, apolipoprotein-B, lipoprotein (a), apolipoprotein AI, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI.
  
  
  RESULTS
  After adjusting for potential confounders, average differences (95% confidence interval) comparing the top to the bottom (reference) serum uric acid were 0.29 (0.19, 0.39) mmol/L for total cholesterol, 0.33 (0.26, 0.41) mmol/L for triglycerides, 0.14 (0.01, 0.27) mmol/L for LDL cholesterol, -0.08 (-0.11, -0.05) mmol/L for HDL, and 0.09 (0.05, 0.12) g/L for serum apolipoprotein-B. Notably, ratios of triglycerides to HDL cholesterol and apolipoprotein-B to AI were also linearly associated with uric acid levels (P for trend < 0.001).
  
  
  CONCLUSIONS
  This study suggested that serum LDL cholesterol, triglycerides, total cholesterol, apolipoprotein-B levels, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI are strongly associated with serum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated. In the clinical practice, the more comprehensive strategic management to deal with dyslipidemia and hyperuricemia deserves further investigation.
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan.
authors: Tao-Chun
authors: 0000-0003-1336-288X
authors: TC
authors: Peng
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan.
authors: Chung-Ching
authors: CC
authors: Wang
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan ; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District,Taipei City 114, Taiwan.
authors: Tung-Wei
authors: TW
authors: Kao
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan ; Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, Minquan E. Road, Neihu District, Taipei City 114, Taiwan.
authors: James Yi-Hsin
authors: JY
authors: Chan
authors: Department of Occupational Safety and Hygiene, Fooyin University, Kaohsiung, Taiwan.
authors: Ya-Hui
authors: YH
authors: Yang
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan ; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District,Taipei City 114, Taiwan.
authors: Yaw-Wen
authors: YW
authors: Chang
authors: Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan ; Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District,Taipei City 114, Taiwan ; Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, Minquan E. Road, Neihu District, Taipei City 114, Taiwan.
authors: Wei-Liang
authors: WL
authors: Chen
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000453:epidemiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood; D014481:United States / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D014527:Uric Acid
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