title: Solid component and tumor size correlate with prognosis of stage IB lung adenocarcinoma.
abstract: BACKGROUND
  Prognostic factors for stage IB lung cancer remain controversial. The International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society proposed a new classification for pulmonary adenocarcinoma. We investigated the prognostic value of this new classification in resected stage IB pulmonary adenocarcinoma.
  
  
  METHODS
  The study included 187 patients with stage IB pulmonary adenocarcinoma. All pathologic slides were reevaluated according to the new classification for pulmonary adenocarcinoma, with each histologic component recorded in 5% increments. Survival analyses were performed to determine the prognostic factors for stage IB pulmonary adenocarcinoma.
  
  
  RESULTS
  Univariable analysis showed tumor size was prognostic for overall survival (hazard ratio [HR], 2.083; p < 0.001) and progression-free survival (HR, 1.991; p < 0.001); gender (HR, 0.558; p = 0.033), presence of the solid component (HR, 1.976; p = 0.016), and presence of a micropapillary component (HR, 2.371; p = 0.018) were prognostic for progression-free survival. Multivariable analysis revealed that tumor size was an independent prognostic factor for overall survival (HR, 2.083; 95% confidence interval, 1.433 to 3.029; p < 0.001) and progression-free survival (HR, 2.036; 95% confidence interval, 1.546 to 2.681; p < 0.001) and that the presence of the solid component (HR, 2.045; 95% confidence interval, 1.172 to 3.568; p = 0.012) was an independent prognostic factor for progression-free survival.
  
  
  CONCLUSIONS
  Solid component and tumor size significantly correlate with prognosis in stage IB pulmonary adenocarcinoma.
authors: Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China.
authors: Songtao
authors: S
authors: Xu
authors: Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China.
authors: Junjie
authors: J
authors: Xi
authors: Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China.
authors: Wei
authors: W
authors: Jiang
authors: Department of Pathology, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China.
authors: Shaohua
authors: S
authors: Lu
authors: Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China. Electronic address: lu.shaohua@zs-hospital.sh.cn.
authors: Qun
authors: Q
authors: Wang
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000401:mortality* / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D047368:Tumor Burden