title: Deep brain light stimulation effects on glutamate and dopamine concentration.
abstract: Compared to deep brain electrical stimulation, which has been applied to treating pathological brain diseases, little work has been done on the effect of deep brain light stimulation. A fiber-coupled laser stimulator at 840 nm wavelength and 130 Hz pulse repetition rate is developed in this work for deep brain light stimulation in a rat model. Concentration changes in glutamate and dopamine in the striatum are observed using a microdialysis probe when the subthalamic nucleus (STN) is stimulated at various optical power levels. Experimental results show that light stimulation causes the concentration of glutamate to decrease while that of dopamine is increased. This suggests that deep brain light stimulation of the STN is a promising therapeutic strategy for dopamine-related diseases such as Parkinson's disease. The stimulator developed for this work is useful for deep brain light stimulation in biomedical research.
authors: Departments of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan ; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
authors: Jinn-Rung
authors: JR
authors: Kuo
authors: Neurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan.
authors: Shih-Shian
authors: SS
authors: Lin
authors: Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Janelle
authors: J
authors: Liu
authors: Neurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan.
authors: Shih-How
authors: SH
authors: Chen
authors: Departments of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors: Chung-Chin
authors: CC
authors: Chio
authors: Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.
authors: Jhi-Joung
authors: JJ
authors: Wang
authors: Neurophotonics Laboratory, College of Photonics, National Chiao Tung University, Tainan, Taiwan ; Department of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
authors: Jia-Ming
authors: JM
authors: Liu
keywords: (170.0170) Medical optics and biotechnology; (170.1420) Biology; (170.1610) Clinical applications; (170.3660) Light propagation in tissues; (170.3890) Medical optics instrumentation; (170.5180) Photodynamic therapy
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