title: Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients.
abstract: OBJECTIVE
  Cardiovascular diseases are more common in patients with nondipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The aim of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients.
  
  
  METHODS
  The study population included newly diagnosed hypertensive patients who were not under antihypertensive treatment. A total of 77 patients were evaluated with ambulatory blood pressure monitoring and divided into two groups: NDHT (n=42) and DHT (n=35). Plasma neurokinin B levels were measured using the ELISA method.
  
  
  RESULTS
  Serum neurokinin B levels were significantly higher in the NDHT group compared with the DHT group [254 (180-888) and 207 (116-752) pg/ml, respectively; P=0.024]. There is a positive correlation between the mean night-time systolic blood pressure and plasma neurokinin levels (r=0.590; P<0.001). On regression analysis, neurokinin B level was only found to be related to the mean night-time systolic blood pressure (unstandardized β=-22.02±9.59; P<0.001).
  
  
  CONCLUSIONS
  Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. There is a need for further studies that search for the relation between serum neurokinin B levels and NDHT.
authors: Departments of aCardiology bBiochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors: Dursun C
authors: DC
authors: Akkoyun
authors: Aydin
authors: A
authors: Akyuz
authors: Seref
authors: S
authors: Alpsoy
authors: Murat
authors: M
authors: Aydin
authors: Kubilay
authors: K
authors: Erselcan
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D006973:Hypertension / Q000097:blood / Q000175:diagnosis; D015287:Neurokinin B / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D015287:Neurokinin B