title: [Effect of Zhibai Dihuang Pill on uPA of Uu-infection infertility patients].
abstract: OBJECTIVE
  To study the effect of Zhibai Dihuang Pill (ZBDHP) on urokinase-type plasminogen activator (uPA) and sperm quality in ureaplasma urealyticum (Uu) infection infertile patients.
  
  
  METHODS
  Recruited were 80 infertility patients with Uu infection at Andriatrics Clinics and Department of Reproduction, including 130 cases of positive Uu semen and 50 cases of negative Uu semen. Patients with positive Uu semen were randomly assigned to the observation group (72 cases) and the control group (58 cases) according to the visit sequence. All patients took antibiotics for 2 weeks. Patients in the observation group additionally took ZBDHP, 6 g each time, twice daily. Those in the control group additionally took Vit E (100 mg each time, twice per day) and ATP (40 mg each time, twice per day). The therapeutic course for all was 90 days. Semen parameters and uPA contents of the sperm membrane were detected and comparatively analyzed.
  
  
  RESULTS
  The sperm membrane uPA content, the sperm motility, the sperm viability, and the percentage of normal morphology sperm in Uu positive infected patients were lower than those in Uu negative infected patients with statistical difference (P < 0.05), but with no significant difference in the sperm density between the two groups (P > 0.05). There was no statistical difference in pre-treatment sperm membrane uPA contents and sperm parameters between the two groups (P > 0.05). Compared with before treatment in the same group, the sperm membrane uPA content, the sperm motility, the sperm viability, and the percentage of normal morphology sperm obviously increased in the two groups with statistical difference (P < 0.05). After treatment, the sperm membrane uPA content increased more obviously in the observation group, with statistical difference when compared with the control group (P < 0.05).
  
  
  CONCLUSIONS
  Infection with Uu leads to decreased uPA content of sperm membrance and the sperm motility. ZBDHP could effectively treat Uu infected infertility possibly through fighting against Uu damaged sperm membrane and make the sperm membrane uPA content return to normal, and elevate the fertilizability of sperms.
authors: Xuan
authors: X
authors: Li
authors: Qing-Hu
authors: QH
authors: He
authors: Yi-Jun
authors: YJ
authors: Wang
authors: Yong
authors: Y
authors: Bai
authors: Ning-Zi
authors: NZ
authors: Kuang
authors: Chao-Sheng
authors: CS
authors: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003141:Communicable Diseases; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007246:Infertility; D007248:Infertility, Male; D008297:Male; D012661:Semen; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa; D016869:Ureaplasma Infections / Q000188:drug therapy*; D016990:Ureaplasma urealyticum / Q000187:drug effects; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; C540472:zhibai dihuang; D014568:Urokinase-Type Plasminogen Activator