title: Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization.
abstract: A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.
authors: Department of Analytical Chemistry, Institute of Chemical Technology in Prague, Technicka 5, 166 28 Prague 6 (Czech Republic); First Faculty of Medicine, Charles University in Prague, Kateřinská 32, 121 08 Prague 2 (Czech Republic).
authors: T
authors: T
authors: Bříza
authors: J
authors: J
authors: Králová
authors: B
authors: B
authors: Dolenský
authors: S
authors: S
authors: Rimpelová
authors: Z
authors: Z
authors: Kejík
authors: T
authors: T
authors: Ruml
authors: M
authors: M
authors: Hajdúch
authors: P
authors: P
authors: Džubák
authors: I
authors: I
authors: Mikula
authors: P
authors: P
authors: Martásek
authors: P
authors: P
authors: Poučková
authors: V
authors: V
authors: Král
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003500:Cyclization; D018738:Hexamethonium / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011810:Quinoxalines / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D011810:Quinoxalines; D018738:Hexamethonium
keywords: cancer; fluorescent probes; methinium salt; mitochondrial localization; quinoxaline; tumor growth suppression