title: Towards understanding of nanoparticle-protein corona.
abstract: With the rapid developments of nanotechnology, chances of exposing nanoscale particles to humans (e.g., workers and consumers) also increase correspondingly, which raises serious concerns on their biosafety. Entrance of nanoparticles into diverse biological environment endows them with new and dynamic biological identities as the so-called nanoparticle-protein corona. Therefore, understanding the role of these nanoparticle-protein coronas and resulting biological responses is crucial, as it helps to clarify the biological mechanism and prevent the potential adverse effects of nanoparticles. In this review, we summarize the latest developments relating to the nanoparticle-protein interaction and corresponding biological responses, with an emphasis on the characterization methods, induced biological effects and possible molecular mechanisms. In addition, we overview both the challenges and opportunities (particularly in nanomedicine) raised by this entrance of nanoparticles into the living creatures, especially human beings, with some future perspectives based on our understanding.
authors: School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.
authors: Cuicui
authors: C
authors: Ge
authors: Jian
authors: J
authors: Tian
authors: Yuliang
authors: Y
authors: Zhao
authors: Chunying
authors: C
authors: Chen
authors: Ruhong
authors: R
authors: Zhou
authors: Zhifang
authors: Z
authors: Chai
mesh_terms: D000327:Adsorption; D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000737:chemistry*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002463:Cell Membrane Permeability; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity*; D010316:Particle Size; D011485:Protein Binding; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001798:Blood Proteins; D011956:Receptors, Cell Surface; D012822:Silicon Dioxide