title: A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.
abstract: The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and recent studies have revealed that c-Kit marks a subpopulation of highly proliferative pancreatic endocrine cells that may harbour islet precursors. c-Kit governs and maintains pancreatic endocrine cell maturation and function via multiple signalling pathways. In this review we address the importance of c-Kit signalling within the pancreas, including its profound role in islet morphogenesis, islet vascularisation, and beta cell survival and function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit as a potential target for the development of cell-based and novel drug therapies in the treatment of diabetes.
authors: Children's Health Research Institute, Victoria Research Laboratories, Room A5-140, 800 Commissioners Road East, London, ON, Canada, N6C 2V5.
authors: Zhi-Chao
authors: ZC
authors: Feng
authors: Matthew
authors: M
authors: Riopel
authors: Alex
authors: A
authors: Popell
authors: Rennian
authors: R
authors: Wang
mesh_terms: D000818:Animals; D002470:Cell Survival; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000201:enzymology* / Q000637:transplantation; D007515:Islets of Langerhans / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D010641:Phenotype; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D019089:Stem Cell Factor / Q000378:metabolism*
chemical_list: D007004:Hypoglycemic Agents; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit
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