title: CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.
abstract: Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E - 07, odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.06-1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E - 08, OR = 1.13, 95% CI 1.08-1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95% CI 0.96-1.10).
authors: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Shuyan
authors: S
authors: Zhang
authors: Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors: Xuling
authors: X
authors: Li
authors: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.
authors: Guoda
authors: G
authors: Ma
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Yongshuai
authors: Y
authors: Jiang
authors: College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
authors: Mingzhi
authors: M
authors: Liao
authors: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors: Rennan
authors: R
authors: Feng
authors: Department of Statistics, Rice University, Houston, TX, USA.
authors: Liangcai
authors: L
authors: Zhang
authors: Department of Neurology, The First Hospital of Harbin, Harbin, China.
authors: Jiafeng
authors: J
authors: Liu
authors: Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
authors: Guangyu
authors: G
authors: Wang
authors: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.
authors: Bin
authors: B
authors: Zhao
authors: School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. qhjiang@hit.edu.cn.
authors: Qinghua
authors: Q
authors: Jiang
authors: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China. keshenli2012@163.com.
authors: Keshen
authors: K
authors: Li
authors: Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China. liuguiyou1981@163.com.
authors: Guiyou
authors: G
authors: Liu
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D051152:Clusterin / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: C495242:CLU protein, human; D051152:Clusterin
keywords: Alzheimer’s disease; Genome-wide association studies (GWAS); Single nucleotide polymorphisms
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