title: [Clinical features and survival analysis of patients with CD20 positive adult B-lineage acute lymphoblastic leukemia].
abstract: OBJECTIVE
  To explore the clinical and survival significance of CD20 positive adult patients with B-lineage acute lymphoblastic leukemia (B-ALL).
  
  
  METHODS
  The clinical features and survival of 168 adult patients with B-ALL diagnosed and treated in our department from May 2007 to July 2011 were analyzed retrospectively, 58 expressed CD20 and 110 not.
  
  
  RESULTS
  The sex, distribution of age, anemia, thrombocytopenia, infiltration of liver, spleen and lymph nodes, the expression of myeloid lineage marker, incidence of Ph chromosome, complete remission within 4 weeks showed no significant differences in CD20 positive and negative groups (P>0.05); median white blood cell count at diagnosis and the rate of patients with high white blood cell count in CD20 positive group were 19.2×10⁹/L and 37.9% respectively, which were significantly higher than those of 6.93 × 10⁹/L and 20.9% in CD20 negative group (P<0.05); cumulative incidence of relapse between two groups showed significant difference (P<0.05); multivariable analysis for overall survival and progress-free survival identified CD20 positivity as independent predictor.
  
  
  CONCLUSIONS
  The expression of CD20 in adult patients with B-ALL appeared to be associated with high white blood cell count and poor prognosis.
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Hao
authors: H
authors: Xu
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Xudong
authors: X
authors: Wei
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Qingsong
authors: Q
authors: Yin
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Ping
authors: P
authors: Wang
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Ruihua
authors: R
authors: Mi
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Hao
authors: H
authors: Ai
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Xiaojiao
authors: X
authors: Wang
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Yufu
authors: Y
authors: Li
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Xinghu
authors: X
authors: Zhu
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Yanli
authors: Y
authors: Zhang
authors: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital, Zhengzhou 450008, China.
authors: Yongping
authors: Y
authors: Song
mesh_terms: D000328:Adult; D018951:Antigens, CD20; D019070:Cell Lineage; D018572:Disease-Free Survival; D006801:Humans; D007958:Leukocyte Count; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D018951:Antigens, CD20
references: Haematologica. 2010 Jun;95(6):1040-2; author reply 1042
references: 20107157
references: Zhonghua Xue Ye Xue Za Zhi. 2011 Apr;32(4):275-7
references: 21569715
references: Blood. 2006 Nov 15;108(10):3302-4
references: 16896151
references: Clin Cancer Res. 2008 Mar 1;14(5):1561-70
references: 18316581
references: J Clin Oncol. 2010 Aug 20;28(24):3880-9
references: 20660823
references: Cancer Res. 2007 Feb 1;67(3):1270-81
references: 17283164
references: Blood. 2009 Jun 18;113(25):6330-7
references: 18703706
references: Haematologica. 2010 Feb;95(2):324-8
references: 19773266