title: Effects of ginger extract on smooth muscle activity of sheep reticulum and rumen.
abstract: Reticulorumen hypomotility leads to the impaired physiologic functions of the digestive tract. Prokinetic action of ginger has been demonstrated in the laboratory animals and human. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger on contraction and motility of reticulum and rumen of ruminants. Collected samples of reticulum and rumen from eight sheep were investigated in vitro. The extract at the concentration of 0.1 and 1.0 mg L(-1) had no effect on any preparations. Contraction of reticulum and rumen preparations was occurred at 10.0 and 100 mg L(-1) concentrations (p < 0.05). Concentration of 1000 mg L(-1) caused a relaxation in preparations contracted with 10.0 and 100 mg L(-1). Likewise, the concentration of 1000 mg L(-1) significantly (p < 0.05) inhibited ACh-induced contraction in both tissues. Six sheep were involved in electromyographic study. Administration of 40 mg kg(-1) of the extract increased the overall frequency of contractions of the reticulum and rumen at the subsequent three days with the prominent increase at the second day (p < 0.05). Results of in vitro study indicated that hydroalcoholic extract of ginger contained spasmogenic and spasmolytic constituents. The results in vivo study represented evidences that the extract may have stimulant effect on reticulorumen motility in 40 mg kg(-1) concentration.
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors: Amin
authors: A
authors: Mamaghani
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors: Masoud
authors: M
authors: Maham
authors: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors: Bahram
authors: B
authors: Dalir-Naghadeh
keywords: Electromyography; Ginger extract; Prokinetic; Reticulorumen hypomotility
references: Am J Vet Res. 2009 Feb;70(2):270-6
references: 19231961
references: Life Sci. 2004 Apr 23;74(23):2889-96
references: 15050426
references: Comp Biochem Physiol A Physiol. 1995 May;111(1):51-8
references: 7735910
references: Dig Dis Sci. 2005 Oct;50(10):1889-97
references: 16187193
references: Vet Res Commun. 2008 Aug;32(6):473-80
references: 18481191
references: Res Vet Sci. 2003 Feb;74(1):93-100
references: 12507571
references: J Physiol. 1970 Nov;210(4):857-82
references: 5501488
references: Res Vet Sci. 1999 Apr;66(2):119-27
references: 10208889
references: Vet Clin North Am Small Anim Pract. 1999 Mar;29(2):377-95
references: 10202795
references: Chem Pharm Bull (Tokyo). 1990 Feb;38(2):430-1
references: 2337957
references: Surgery. 1999 Nov;126(5):918-24
references: 10568192
references: Phytochemistry. 2008 Jan;69(2):299-322
references: 17919666
references: Zentralbl Veterinarmed A. 1995 Dec;42(10):613-31
references: 8822186
references: Phytomedicine. 2005 Sep;12(9):684-701
references: 16194058
references: Methods Find Exp Clin Pharmacol. 2001 Nov;23(9):501-3
references: 11876024
references: Vet Res Commun. 2009 Jan;33(1):33-48
references: 18537051
references: Am J Vet Res. 1996 Dec;57(12 ):1771-5
references: 8950433
references: Vet Res Commun. 1982 Nov;5(4):363-7
references: 6186070
references: World J Gastroenterol. 2004 Nov 15;10(22):3292-8
references: 15484303
references: Am J Vet Res. 2006 Apr;67(4):707-14
references: 16579766
references: Planta Med. 2002 Oct;68(10):936-9
references: 12391562
references: J Ethnopharmacol. 1998 Aug;62(1):49-55
references: 9720611
references: Int J Food Sci Nutr. 2006 Feb-Mar;57(1-2):65-73
references: 16849115
references: Vet J. 2010 Apr;184(1):88-94
references: 19272820
references: J Endocrinol. 1990 Jan;124(1):109-15
references: 2299269