title: Association of CCL13 levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis.
abstract: OBJECTIVE
  CCL13, a recently identified CC chemokine, plays an important role in the process of joint destruction, which is considered a common cause for osteoarthritis (OA). This study aims to examine the relation of CCL13 levels in serum and synovial fluid (SF) with the radiographic severity of OA.
  
  
  METHODS
  CCL13 levels in serum and SF were evaluated using enzyme-linked immunosorbent assay method in 240 patients with knee OA and 134 control subjects. The progression of OA was classified using the Kellgren-Lawrence (KL) system by evaluating x-ray changes observed in anteroposterior knee radiography.
  
  
  RESULTS
  Knee OA patients had higher levels of serum CCL13 compared with control subjects. Knee OA patients with KL grade 4 showed significantly elevated CCL13 levels in serum and SF compared with those with KL grades 2 and 3. Knee OA patients with KL grade 3 had significantly higher SF levels of CCL13 compared with those with KL grade 2. CCL13 levels in serum and SF of knee OA patients were significantly correlated with disease severity evaluated by KL grading criteria.
  
  
  CONCLUSIONS
  CCL13 levels in serum and SF were correlated with the radiographic severity of OA. CCL13 levels in serum and SF may serve as a biomarker for the progression of OA.
authors: From the *Department of Orthopaedic Surgery of Emergency and †The Fourth Department of Orthopaedic Surgery, The Second Affiliated Hospital of Harbin Medical University; ‡Department of Orthopaedic Surgery, No.1 Hospital of Harbin; and §The Third Department of Orthopaedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors: Feng
authors: F
authors: Gao
authors: Jun
authors: J
authors: Tian
authors: Haile
authors: H
authors: Pan
authors: Jun
authors: J
authors: Gao
authors: Meng
authors: M
authors: Yao
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018945:Monocyte Chemoattractant Proteins / Q000097:blood*; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000000981:diagnostic imaging*
chemical_list: C099677:CCL13 protein, human; D018945:Monocyte Chemoattractant Proteins