title: Porcine models of digestive disease: the future of large animal translational research.
abstract: There is increasing interest in nonrodent translational models for the study of human disease. The pig, in particular, serves as a useful animal model for the study of pathophysiological conditions relevant to the human intestine. This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies. The pig has proven its utility for the study of fundamental disease conditions such as ischemia-reperfusion injury, stress-induced intestinal dysfunction, and short bowel syndrome. Pigs have also shown great promise for the study of intestinal barrier function, surgical tissue manipulation and intervention, as well as biomaterial implantation and tissue transplantation. Advantages of pig models highlighted by these studies include the physiological similarity to human intestine and mechanisms of human disease. Emerging future directions for porcine models of human disease include the fields of transgenics and stem cell biology, with exciting implications for regenerative medicine.
authors: Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina. Electronic address: Lmgonza4@ncsu.edu.
authors: Liara M
authors: LM
authors: Gonzalez
authors: Department of Population Health and Pathobiology, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina.
authors: Adam J
authors: AJ
authors: Moeser
authors: Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina.
authors: Anthony T
authors: AT
authors: Blikslager
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004066:Digestive System Diseases / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D041981:Gastrointestinal Tract / Q000033:anatomy & histology / Q000098:blood supply / Q000293:injuries; D006801:Humans; D007422:Intestines / Q000637:transplantation; D015427:Reperfusion Injury / Q000209:etiology; D012778:Short Bowel Syndrome / Q000209:etiology / Q000628:therapy; D013045:Species Specificity; D013315:Stress, Psychological / Q000150:complications; D013552:Swine; D057170:Translational Research, Biomedical; D014945:Wound Healing
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