title: A review of the relationship between leg power and selected chronic disease in older adults.
abstract: OBJECTIVE
  This review investigates the relationship between leg muscle power and the chronic conditions of osteoarthritis, diabetes mellitus, and cardiovascular disease among older adults. Current literature assessing the impact of chronic disease on leg power has not yet been comprehensively characterized. Importantly, individuals with these conditions have shown improved leg power with training.
  
  
  METHODS
  A search was performed using PubMed to identify original studies published in English from January 1998 to August 2013. Leg power studies, among older adults ≥ 50 years of age, which assessed associations with osteoarthritis, diabetes mellitus, and/or cardiovascular disease were selected. Studies concerning post-surgery rehabilitation, case studies, and articles that did not measure primary results were excluded.
  
  
  RESULTS
  Sixteen studies met inclusion criteria, addressing osteoarthritis (n=5), diabetes mellitus (n=5), and cardiovascular disease (n=6). Studies generally supported associations of lower leg power among older adults with chronic disease, although small sample sizes, cross-sectional data, homogenous populations, varied disease definitions, and inconsistent leg power methods limited conclusions.
  
  
  CONCLUSIONS
  Studies suggest that osteoarthritis, diabetes mellitus, and cardiovascular disease are associated with lower leg power compared to older adults without these conditions. These studies are limited, however, by the heterogeneity in study populations and a lack of standardized measurements of leg power. Future larger studies of more diverse older adults with well-defined chronic disease using standard measures of leg power and interventions to improve leg power in these older adults with chronic disease are needed.
authors: Elsa S. Strotmeyer, PhD, MPH, Department of Epidemiology, University of Pittsburgh, 130 North Bellefield Avenue, Room 515, Pittsburgh, PA 15213, USA. Telephone: 412-383-1293 Fax: 412-383-1308 strotmeyere@edc.pitt.edu.
authors: S E
authors: SE
authors: Strollo
authors: P
authors: P
authors: Caserotti
authors: R E
authors: RE
authors: Ward
authors: N W
authors: NW
authors: Glynn
authors: B H
authors: BH
authors: Goodpaster
authors: E S
authors: ES
authors: Strotmeyer
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D007866:Leg / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D010003:Osteoarthritis / Q000503:physiopathology*; D018401:Sample Size
references: Can J Appl Physiol. 2001 Apr;26(2):217-37
references: 11312417
references: Eur J Appl Physiol. 2001 Mar;84(3):206-12
references: 11320637
references: J Am Geriatr Soc. 2001 Jun;49(6):808-23
references: 11480416
references: Diabetes Care. 2002 Jan;25(1):61-7
references: 11772902
references: J Appl Physiol (1985). 2002 Feb;92(2):672-8
references: 11796680
references: J Am Geriatr Soc. 2001 Nov;49(11):1418-27
references: 11890578
references: Age Ageing. 2002 Mar;31(2):119-25
references: 11937474
references: J Am Geriatr Soc. 2002 Mar;50(3):461-7
references: 11943041
references: J Am Geriatr Soc. 2002 Apr;50(4):655-62
references: 11982665
references: J Am Geriatr Soc. 2002 Apr;50(4):663-70
references: 11982666
references: J Appl Physiol (1985). 2002 Aug;93(2):457-62
references: 12133850
references: JAMA. 2003 Mar 19;289(11):1371-3
references: 12636453
references: Eur J Appl Physiol Occup Physiol. 1990;60(5):385-90
references: 2369911
references: BMJ. 2003 Jun 28;326(7404):1419
references: 12829553
references: Postgrad Med J. 2003 Jul;79(933):377-83
references: 12897215
references: JAMA. 2003 Oct 8;290(14):1884-90
references: 14532317
references: Diabetes Care. 2003 Dec;26(12):3257-63
references: 14633811
references: Eur J Appl Physiol. 2003 Nov;90(5-6):458-63
references: 12883896
references: J Am Geriatr Soc. 2004 Mar;52(3):405-10
references: 14962156
references: J Cardiol. 2004 Feb;43(2):59-68
references: 15017785
references: J Am Geriatr Soc. 2004 May;52(5):799-804
references: 15086665
references: Diabetes. 2004 Jun;53(6):1543-8
references: 15161759
references: Arch Phys Med Rehabil. 2004 Jul;85(7 Suppl 3):S31-42; quiz S43-4
references: 15221722
references: Prog Cardiovasc Dis. 1975 Nov-Dec;18(3):181-99
references: 1103232
references: Clin Sci (Lond). 1992 Mar;82(3):321-7
references: 1312417
references: Int J Tissue React. 1993;15(3):93-7
references: 8188450
references: Br Heart J. 1994 Aug;72(2 Suppl):S36-9
references: 7946756
references: Med Sci Sports Exerc. 1996 Oct;28(10):1321-6
references: 8897391
references: Diabetologia. 1997 Sep;40(9):1062-9
references: 9300243
references: J Appl Physiol (1985). 1998 Apr;84(4):1341-9
references: 9516202
references: Clin Rehabil. 1998 Apr;12(2):120-6
references: 9619653
references: Eur J Appl Physiol Occup Physiol. 1998 Jun;78(1):59-64
references: 9660157
references: Clin Rehabil. 2004 Nov;18(7):793-800
references: 15573836
references: J Gerontol A Biol Sci Med Sci. 2004 Nov;59(11):1200-6
references: 15602076
references: Arthritis Rheum. 2006 Jan;54(1):226-9
references: 16385518
references: BMJ. 2006 Mar 18;332(7542):639-42
references: 16543327
references: Clin Neuropathol. 1984 Nov-Dec;3(6):240-52
references: 6097384
references: Circulation. 1986 Oct;74(4):775-9
references: 3757189
references: Arthritis Rheum. 1987 Aug;30(8):914-8
references: 3632732
references: J Rheumatol. 1988 Dec;15(12):1833-40
references: 3068365
references: Eur J Vasc Surg. 1989 Aug;3(4):315-22
references: 2767254
references: Diabetes. 2006 Jun;55(6):1813-8
references: 16731847
references: Am J Phys Med Rehabil. 2006 Aug;85(8):650-8
references: 16865019
references: Diabetes Care. 2006 Sep;29(9):2120-2
references: 16936164
references: JAMA. 2007 Mar 21;297(11):1253-5
references: 17374819
references: Arch Phys Med Rehabil. 2007 May;88(5):604-9
references: 17466729
references: Phys Ther. 2008 Nov;88(11):1336-44
references: 18801853
references: J Sports Sci. 2008 Nov;26(13):1431-6
references: 18923959
references: Scand J Med Sci Sports. 2008 Dec;18(6):773-82
references: 18248533
references: Am J Phys Med Rehabil. 2009 Nov;88(11):934-40
references: 19893385
references: J Am Geriatr Soc. 2009 Nov;57(11):2004-10
references: 19793163
references: Diabetes Care. 2010 May;33(5):1055-60
references: 20185736
references: J Strength Cond Res. 2010 Dec;24(12):3369-80
references: 21068681
references: Circulation. 2011 Feb 1;123(4):e18-e209
references: 21160056
references: Braz J Med Biol Res. 2011 Sep;44(9):827-35
references: 21956529
references: Appl Physiol Nutr Metab. 2011 Oct;36(5):626-33
references: 21980994
references: Exerc Sport Sci Rev. 2012 Jan;40(1):4-12
references: 22016147
references: Arthritis Care Res (Hoboken). 2012 Jan;64(1):46-53
references: 22012877
references: J Am Coll Cardiol. 2012 Mar 27;59(13):1159-67
references: 22440216
references: J Appl Physiol (1985). 2012 Jul;113(2):255-62
references: 22604883
references: Diabetes Care. 2012 Aug;35(8):1672-9
references: 22596176
references: Med Sci Sports Exerc. 2013 Jan;45(1):52-9
references: 22843109
references: J Am Geriatr Soc. 2013 May;61(5):769-75
references: 23617584
references: Diabetes Care. 2007 Jun;30(6):1507-12
references: 17363749
references: J Strength Cond Res. 2007 May;21(2):518-26
references: 17530980
references: J Gerontol A Biol Sci Med Sci. 2007 Aug;62(8):851-8
references: 17702876
references: J Diabetes Complications. 2008 Mar-Apr;22(2):112-8
references: 18280441
references: J Appl Physiol (1985). 2008 Mar;104(3):739-46
references: 18174392
references: Arch Phys Med Rehabil. 2008 Apr;89(4):677-83
references: 18373998
references: J Am Geriatr Soc. 2008 Apr;56(4):724-9
references: 18284536
references: Arch Phys Med Rehabil. 2008 Jun;89(6):1066-73
references: 18503801
references: Diabetes Care. 2008 Sep;31(9):1767-72
references: 18535192
references: J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M192-9
references: 10811148
references: Phys Med Rehabil Clin N Am. 2000 May;11(2):341-68, vii
references: 10810765
references: J Gerontol A Biol Sci Med Sci. 2000 Jun;55(6):M309-10
references: 10843349
references: Diabetes Care. 2000 Sep;23(9):1272-7
references: 10977018