title: Incidence of lymphatic involvement in differentiated-type intramucosal gastric cancers as examined by endoscopic resection.
abstract: BACKGROUND
  Lymphatic involvement may sometimes be detected in differentiated-type intramucosal cancer resected endoscopically during routine examination, but its incidence and clinical significance remain unknown.
  
  
  METHODS
  We examined 300 endoscopically resected lesions obtained from 238 patients diagnosed with differentiated-type intramucosal gastric cancer. All sections were subjected to D2-40 monoclonal-based immunohistochemistry.
  
  
  RESULTS
  The incidence of lymphatic involvement in differentiated-type intramucosal cancer was 2.0% (6/300). An incidence of 1.8% (5/279) was determined in lesions that were ≤ 3 cm in size and 2.2% (6/276) in those without an ulcer or ulcer scar. Of the six lesions presenting lymphatic involvement, three were determined to be histologically mixed with a predominance of differentiated type, while the other three lesions were pure differentiated type.
  
  
  CONCLUSIONS
  We determined that the incidence of lymphatic involvement in differentiated-type intramucosal cancer was 2.0%. To clarify the clinical significance of such lymphatic involvement, it is necessary to detect it with this incidence in mind and to gather and follow up the clinical courses of such cases.
authors: Department of Pathology, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto-shi, Kyoto, 602-8566, Japan. bkm@koto.kpu-m.ac.jp.
authors: Yasuko
authors: Y
authors: Fujita
authors: Department of Pathology, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto-shi, Kyoto, 602-8566, Japan.
authors: Mitsuo
authors: M
authors: Kishimoto
authors: Department of Surgical Pathology, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, Japan.
authors: Ryuta
authors: R
authors: Nakao
authors: Department of Medical Oncology, Fukushima Medical University, Fukushima, Japan.
authors: Reiko
authors: R
authors: Kimura-Tsuchiya
authors: Department of Gastroenterology, Murakami Memorial Hospital, Asahi University, Gifu, Japan.
authors: Nobuaki
authors: N
authors: Yagi
authors: Department of Pathology, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto-shi, Kyoto, 602-8566, Japan.
authors: Akio
authors: A
authors: Yanagisawa
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000453:epidemiology / Q000473:pathology; D002454:Cell Differentiation; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D042601:Lymphatic Vessels / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology*
keywords: Adenocarcinoma; D2-40 monoclonal antibody; Gastrointestinal endoscopy; Stomach neoplasm
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