title: Delaying discharge after the stimulus significantly decreases muscle activation thresholds with small impact on the selectivity: an in vivo study using TIME.
abstract: The number of devices for electrical stimulation of nerve fibres implanted worldwide for medical applications is constantly increasing. Stimulation charge is one of the most important parameters of stimulation. High stimulation charge may cause tissue and electrode damage and also compromise the battery life of the electrical stimulators. Therefore, the objective of minimizing stimulation charge is an important issue. Delaying the second phase of biphasic stimulation waveform may decrease the charge required for fibre activation, but its impact on stimulation selectivity is not known. This information is particularly relevant when transverse intrafascicular multichannel electrode (TIME) is used, since it has been designed to provide for high selectivity. In this in vivo study, the rat sciatic nerve was electrically stimulated using monopolar and bipolar configurations with TIME. The results demonstrated that the inclusion of a 100-μs delay between the cathodic and the anodic phase of the stimulus allows to reduce charge requirements by around 30 %, while only slightly affecting stimulation selectivity. This study shows that adding a delay to the typical stimulation waveform significantly ([Formula: see text]) reduces the charge required for nerve fibres activation. Therefore, waveforms with the delayed discharge phase are more suitable for electrical stimulation of nerve fibres.
authors: DEMAR Team, LIRMM, INRIA, University of Montpellier 2, Montpellier, France, pmaciejasz@axonic.fr.
authors: Paweł
authors: P
authors: Maciejasz
authors: Jordi
authors: J
authors: Badia
authors: Tim
authors: T
authors: Boretius
authors: David
authors: D
authors: Andreu
authors: Thomas
authors: T
authors: Stieglitz
authors: Winnie
authors: W
authors: Jensen
authors: Xavier
authors: X
authors: Navarro
authors: David
authors: D
authors: Guiraud
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods*; D004567:Electrodes, Implanted; D004576:Electromyography; D018482:Muscle, Skeletal / Q000502:physiology; D058117:Neural Prostheses; D011474:Prosthesis Design; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology
references: IEEE Trans Biomed Eng. 1983 Jul;30(7):407-14
references: 6604691
references: IEEE Trans Neural Syst Rehabil Eng. 2012 May;20(3):395-404
references: 22481834
references: IEEE Trans Neural Syst Rehabil Eng. 2014 Mar;22(2):400-10
references: 23799699
references: Muscle Nerve. 2010 Aug;42(2):192-201
references: 20544926
references: J Neurosci Methods. 2005 Feb 15;141(2):171-98
references: 15661300
references: J Neural Eng. 2009 Apr;6(2):026001
references: 19213992
references: IEEE Trans Biomed Eng. 1993 Jul;40(7):640-53
references: 8244425
references: Int Rev Neurobiol. 2013;109:63-83
references: 24093606
references: Hear Res. 2006 May;215(1-2):47-55
references: 16644157
references: J Neural Eng. 2014 Feb;11(1):016007
references: 24654269
references: Hear Res. 1999 Apr;130(1-2):171-88
references: 10320107
references: IEEE Trans Biomed Eng. 2011 Aug;58(8):null
references: 21571604
references: J Neural Eng. 2006 Dec;3(4):276-86
references: 17124331
references: J Neural Eng. 2011 Jun;8(3):036023
references: 21558601
references: PM R. 2011 Jan;3(1):55-67
references: 21257135
references: Biomed Tech (Berl). 2012 Dec;57(6):457-65
references: 23037514
references: Ann Biomed Eng. 1979;7(2):117-25
references: 533020
references: Front Neuroeng. 2011 Sep 28;4:9
references: 22007167
references: IEEE Trans Biomed Eng. 1986 Oct;33(10):974-7
references: 3770787