title: Bioadhesion in ascidians: a developmental and functional genomics perspective.
abstract: The development of bioadhesives inspired from marine animals is a promising approach to generate new tissue-compatible medical components. A number of marine species, through their adhesive properties, also represent significant foulers that become increasingly problematic to aquaculture, shipping or local biodiversity. In order to develop more sophisticated man-made glues and/or efficient fouling resistant surfaces, it is important to understand the mechanical, structural and molecular properties of adhesive organs in selected species. Ascidians are marine invertebrates with larvae that opportunistically attach to almost any type of submerged surface to undergo metamorphosis into permanently sessile adults. Not only do they represent a globally important fouling organism, but they are becoming increasingly popular as model organisms for developmental biology. The latter is due to their phylogenetic position as the sister group to the vertebrates and their cellular and molecular accessibility for experimentation. In this paper, we review the mechanisms of larval adhesion in ascidians and draw conclusions from comparative analyses of selected species. We further discuss how knowledge from a developmental and functional genomics point of view can advance our understanding of cellular and molecular signatures and their hierarchical usage in animal adhesive organs.
authors: Dipartimento di Biologia , Università degli Studi di Milano , Milan , Italy.
authors: Roberta
authors: R
authors: Pennati
authors: Department of Evolution and Developmental Biology, Zoological Institute , University Innsbruck , Innsbruck , Austria.
authors: Ute
authors: U
authors: Rothbächer
keywords: ascidians; bioadhesion; functional genomics; gene networks; papillae
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