title: 25-Hydroxyvitamin D Supplementation and BMI Change: A Meta-Analysis of Randomized Controlled Trials.
abstract: The impact of 25-hydroxyvitamin D (25[OH]D) supplementation on weight change remains controversial. The objective of this study was to summarize the effects of 25[OH]D supplementation (cholecalciferol or ergocalciferol) on BMI change through a meta-analysis of published clinical trials. We completed a systematic review of English articles, using MEDLINE (Ovid, Pubmed) from January 1, 1998 through January 1, 2013. The articles selected focused on 25[OH]D supplementation and body mass index (BMI) in randomized controlled trials (RCT's). The association between 25[OH]D and mean BMI change was estimated utilizing a random effects model. A total of 30 studies were reviewed and 9 were included in the meta-analysis. Total participants included 1651 adults (82.6% women and mean age 47.9 years) and mean follow-up ranged between 6 to 196 weeks and mean daily 25[OH]D dose ranged from 200 IU to 1,110 IU. Five of the 9 studies included calcium supplementation in both groups. Average baseline BMI was 30.7 and 30.4 kg/m2in the intervention and control groups, respectively. Five studies suggested a beneficial effect for 25[OH]D supplementation for BMI change whereas 3 studies showed no effect of 25[OH]D supplementation on BMI change, and one showed a non-perceptible change. Meta-analysis of BMI values at end of trial showed no statistically significant difference in BMI change by use of 25[OH]D supplementation. Based on existing published trials, oral 25[OH]D supplementation does not significantly impact BMI change.
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: N
authors: N
authors: Mora
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: K
authors: K
authors: Rieke
authors: Departments of Surgery, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: J
authors: J
authors: Plitcha
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: Aj
authors: A
authors: Segura
authors: Medicine, Division of Nephrology and Hypertension, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: D
authors: D
authors: Leehey
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: K
authors: K
authors: DeShong
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA ; Medicine, Division of Nephrology and Hypertension, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA ; Department of Preventive Medicine and Epidemiology, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: H
authors: H
authors: Kramer
authors: Public Health Program, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA ; Department of Preventive Medicine and Epidemiology, Loyola University Chicago Health Sciences Center, Chicago, Illinois, USA.
authors: Ramon A
authors: RA
authors: Durazo-Arvizu
keywords: 25-hydroxyvitamin D (25[OH]D); Body Mass Index (BMI); Meta-analysis; Obesity; Vitamin D
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