title: Pharmacokinetics of pergolide after intravenous administration to horses.
abstract: OBJECTIVE
  To determine the pharmacokinetics of pergolide after IV administration to horses.
  
  
  METHODS
  8 healthy adult horses.
  
  
  METHODS
  Pergolide mesylate was administered IV at a dose of 20 μg/kg (equivalent to 15.2 μg of pergolide/kg) to each horse, and blood samples were collected over 48 hours. Pergolide concentrations in plasma were determined by means of high-performance liquid chromatography-tandem mass spectrometry, and pharmacokinetic parameters were determined on the basis of noncompartmental methods.
  
  
  RESULTS
  After IV administration of pergolide, mean ± SD clearance, elimination half-life, and initial volume of distribution were 959 ± 492 mL/h/kg, 5.64 ± 2.36 hours, and 0.79 ± 0.32 L/kg, respectively.
  
  
  CONCLUSIONS
  With an elimination half-life of approximately 6 hours, twice-daily dosing may be more appropriate than once-daily dosing to reduce peak-trough fluctuation in pergolide concentrations. Further pharmacodynamic and pharmacokinetic studies of pergolide and its metabolites will be necessary to determine plasma concentrations that correlate with clinical effectiveness to determine the therapeutic range for the treatment of pituitary pars intermedia dysfunction.
authors: School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia.
authors: David I
authors: DI
authors: Rendle
authors: Kris J
authors: KJ
authors: Hughes
authors: Gregory S
authors: GS
authors: Doran
authors: Scott H
authors: SH
authors: Edwards
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D002853:Chromatography, Liquid / Q000662:veterinary; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006736:Horses / Q000378:metabolism*; D008297:Male; D010479:Pergolide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D053719:Tandem Mass Spectrometry / Q000662:veterinary
chemical_list: D018491:Dopamine Agonists; D010479:Pergolide