title: [Reduction of functional mobility and cognitive capacity in type 2 diabetes mellitus].
abstract: OBJECTIVE
  The aim of the present study was to evaluate the functional mobility and its relationship to cognitive ability in patients with type 2 diabetes (T2DM), age between 50 and 65 years and under 10 years of diagnosis.
  
  
  METHODS
  An observational, analytical and cross-sectional study, involving no diabetic and type 2 diabetic individuals with inadequate glycemic control, selected by convenience sampling. In both groups, were administered structured questionnaire and cognitive assessment with Mini-Mental State Examination (MMSE) and the clock drawing test (CDT), besides assessment of functional mobility by the Timed Up & Go (TUG).
  
  
  RESULTS
  In TUG, DM2 patients presented a mean time of 11.27 seconds versus 9.52 seconds (p = 0.013). The association between cognitive decline and decrease of mobility was positive in individuals with T2DM (p = 0.037). In the subgroup that showed decrease of mobility and associated cognitive decline, 18% were patients with DM2 and 1.6% were individuals without T2DM (p < 0.01).
  
  
  CONCLUSIONS
  Patients with T2DM presented worse functional mobility and cognitive performance, supporting the hypothesis that DM2 influence functional mobility and cognitive ability, regardless of neuropathic or vascular complications. These data suggest that hyperglycemia is an aggravating factor in the performance of activities requiring mental functions such as attention, working memory and orientation.
authors: Faculdade de Medicina, Universidade de São Paulo.
authors: Mari Cassol
authors: MC
authors: Ferreira
authors: Universidade Comunitária Regional de Chapecó, Chapecó, SC, Brasil.
authors: Joana
authors: J
authors: Tozatti
authors: Universidade Comunitária Regional de Chapecó, Chapecó, SC, Brasil.
authors: Silvia Maria
authors: SM
authors: Fachin
authors: Instituto Fernandes Figueira, Fundação Oswaldo Cruz.
authors: Patricia Pereira de
authors: PP
authors: Oliveira
authors: LIM-18, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors: Rosa Ferreira dos
authors: RF
authors: Santos
authors: LIM-18, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors: Maria Elisabeth Rossi da
authors: ME
authors: Silva
mesh_terms: D000058:Accidental Falls; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D010809:Physical Fitness / Q000502:physiology*; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose