title: Intense pruritus in Epstein-Barr virus (EBV) hepatitis treated with naloxone drip.
abstract: Pruritus is a manifestation of chronic liver disease. Epstein-Barr virus (EBV) infection often presents as infectious mononucleosis and mild hepatitis. Severe pruritus in the setting of infectious mononucleosis and persistent marked hyperbilirubinaemia is exceedingly uncommon. To the best of our knowledge, we present the first case of a patient with EBV hepatitis and severe pruritus that was successfully treated with an ultra-low dose of intravenous naltraxone.
authors: Division of Gastroenterology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
authors: Satyanisth
authors: S
authors: Agrawal
authors: Division of Gastroenterology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
authors: Ryan
authors: R
authors: O'Connor
authors: Division of Gastroenterology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
authors: Elie
authors: E
authors: Aoun
authors: Division of Gastroenterology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
authors: Michael
authors: M
authors: Babich
mesh_terms: D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D007262:Infusions, Intravenous; D007565:Jaundice / Q000821:virology; D008297:Male; D009270:Naloxone / Q000008:administration & dosage*; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D011537:Pruritus / Q000188:drug therapy* / Q000821:virology
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone
references: Baillieres Clin Gastroenterol. 1987 Apr;1(2):211-30
references: 2822180
references: Gastroenterology. 2000 Feb;118(2):431-2
references: 10648471
references: J Biol Chem. 1995 Mar 24;270(12):6702-9
references: 7896813
references: Semin Liver Dis. 1997 Feb;17(1):23-33
references: 9089908
references: Br J Clin Pract. 1995 Jul-Aug;49(4):212-3
references: 7547164
references: Gastroenterology. 1992 Feb;102(2):544-9
references: 1732125
references: Addict Biol. 1996;1(1):19-30
references: 12893484
references: Ann Intern Med. 1995 Aug 1;123(3):161-7
references: 7598296
references: BMJ. 1988 Dec 10;297(6662):1501-4
references: 3147046
references: Arch Intern Med. 1987 May;147(5):850-3
references: 3034177
references: Dig Dis Sci. 1998 Oct;43(10):2177-83
references: 9790451