title: The effect of intracoronary administration of ergonovine on the contralateral coronary artery in a provocation test for the diagnosis of variant angina.
abstract: BACKGROUND
  Little is known about the effects of selective intracoronary administration of ergonovine into a coronary artery on the artery on the other side. This study aimed to evaluate the effect of intracoronarily administered ergonovine on the contralateral coronary artery.
  
  
  METHODS
  From June 2011 to August 2013, coronary spasm provocation tests were performed in 85 consecutive patients using selective intracoronary administration of methylergometrine maleate (ER).The doses increased in a step-wise manner up to 60 μg for the left coronary artery (LCA) and up to 50 μg for the right coronary artery (RCA).The coronary artery diameters were measured and analysed by repeated-measures ANOVA.
  
  
  RESULTS
  Twenty-four (28%) patients had a spasm-positive result. The mean diameter of the spasm segment in the contralateral artery decreased from 2.83 to 2.68 mm (5.1 ± 0.1% change, P < 0.001) in the negative spasm group and from 2.40 to 2.10 mm (11.1 ± 2.2% change, P = 0.001) in the positive spasm group. There were no serious procedure-related complications.
  
  
  CONCLUSIONS
  Intracoronary administration of ER resulted in a statistically significant decrease of lumen diameter of the contralateral coronary artery. However, from the clinical perspective, the extent of the decrease was relatively small and the test may be conducted safely unless there is a significant coronary artery luminal narrowing.
authors: Jin Hee
authors: JH
authors: Kim
authors: Changhoon
authors: C
authors: Kim
authors: Jeongsu
authors: J
authors: Kim
authors: Jin Sup
authors: JS
authors: Park
authors: Hye Won
authors: HW
authors: Lee
authors: Jung Hyun
authors: JH
authors: Choi
authors: Han Cheol
authors: HC
authors: Lee
authors: Kwang Soo
authors: KS
authors: Cha
authors: Taek Jong
authors: TJ
authors: Hong
authors: Jun-Hyok
authors: JH
authors: Oh
mesh_terms: D000788:Angina Pectoris, Variant / Q000175:diagnosis*; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced*; D003331:Coronary Vessels / Q000187:drug effects*; D004874:Ergonovine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010120:Oxytocics / Q000008:administration & dosage*
chemical_list: D010120:Oxytocics; D004874:Ergonovine