title: Prostate perfusion mapped by technetium-99m macroaggregated albumin after selective arterial injection.
abstract: OBJECTIVE
  To determine if perfusion of the prostate can be mapped using technetium-99m ((99m)Tc) macroaggregated albumin (MAA) after selective prostate artery catheterization.
  
  
  METHODS
  Selective prostate artery injections of MAA were performed and analyzed in 14 patients; 9 patients received unilateral injection, and 5 patients received bilateral injections (37 MBq/1 mCi per injection). Fused single-photon emission computed tomography/computed tomography (SPECT/CT) images were subsequently acquired using a fiducial marker technique. Perfusion distribution was assessed, and relative intraprostatic versus extraprostatic activity was quantified and compared between groups.
  
  
  RESULTS
  The percentage of the prostate gland containing activity was significantly greater for the bilateral injection group compared with the unilateral injection group (76.6% vs 44.3%, P < .05). The percentage of relative intraprostatic versus extraprostatic activity was significantly lower for the bilateral injection group compared with the unilateral injection group (40.3% vs 75.9%, P < .05). Sites of visualized extraprostatic activity included the seminal vesicles (8 of 14 patients), internal iliac vessels (7 of 14 patients), bladder wall (5 of 14 patients), space of Retzius (3 of 14 patients), rectal wall (3 of 14 patients), and penis (1 of 14 patients).
  
  
  CONCLUSIONS
  Perfusion mapping with (99m)Tc-MAA can be effectively performed with SPECT/CT after selective prostate artery catheterization. The relative percentage of intraprostatic versus extraprostatic activity can be quantified, and the distribution of activity within and outside the prostate gland can be determined.
authors: Department of Radiology and Diagnostic Imaging, Surgery, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7. Electronic address: jabele@ualberta.ca.
authors: Jonathan T
authors: JT
authors: Abele
authors: Division of Urology, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7.
authors: Ronald
authors: R
authors: Moore
authors: Department of Cardiology, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7.
authors: Wayne
authors: W
authors: Tymchak
authors: Department of Radiology and Diagnostic Imaging, Surgery, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7.
authors: Richard J
authors: RJ
authors: Owen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D055420:Perfusion Imaging / Q000379:methods*; D011467:Prostate / Q000000981:diagnostic imaging / Q000503:physiopathology*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin