title: Mathematical modelling of hepatic lipid metabolism.
abstract: The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-h period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin.
authors: Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK; Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Electronic address: stxap@nottingham.ac.uk.
authors: Adrian C
authors: AC
authors: Pratt
authors: Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Electronic address: Jonathan.Wattis@nottingham.ac.uk.
authors: Jonathan A D
authors: JA
authors: Wattis
authors: Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK. Electronic address: Andrew.Salter@nottingham.ac.uk.
authors: Andrew M
authors: AM
authors: Salter
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D055641:Mathematical Concepts; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism
chemical_list: D007328:Insulin; D005947:Glucose
keywords: Carbohydrate metabolism; Fat metabolism; Mathematical models