title: Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.
abstract: Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders. From the clinical editor: Nanoneuromedicine is a branch of nanomedicine that specifically looks at the nervous system. In the clinical setting, a fundamental hurdle in nervous system disorders is due to an inherent inability of nerve cells to regenerate after damage. Nanotechnology can offer new approaches to overcome these challenges. This review describes recent developments in nanomedicine delivery systems that would affect stem cell repair and regeneration in the nervous system.
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA. Electronic address: suryakm@iastate.edu.
authors: Surya K
authors: SK
authors: Mallapragada
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
authors: Timothy M
authors: TM
authors: Brenza
authors: Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE, USA.
authors: JoEllyn M
authors: JM
authors: McMillan
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
authors: Balaji
authors: B
authors: Narasimhan
authors: Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA USA.
authors: Donald S
authors: DS
authors: Sakaguchi
authors: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
authors: Anup D
authors: AD
authors: Sharma
authors: Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA USA.
authors: Svitlana
authors: S
authors: Zbarska
authors: Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: hegendel@unmc.edu.
authors: Howard E
authors: HE
authors: Gendelman
mesh_terms: D000375:Aging; D016503:Drug Delivery Systems / Q000379:methods*; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000378:metabolism / Q000628:therapy*; D058953:Neural Stem Cells
keywords: Drug development; Nanoformulation; Nanoneuromedicine; Nanotechnology; Targeting
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