title: Immunity unmasks APOL1 in collapsing glomerulopathy.
abstract: Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
authors: Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
authors: Bairbre A
authors: BA
authors: McNicholas
authors: Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
authors: Peter J
authors: PJ
authors: Nelson
mesh_terms: D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008075:Lipoproteins, HDL / Q000235:genetics*; D008297:Male
chemical_list: D001053:Apolipoproteins; D008075:Lipoproteins, HDL