title: N-heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals.
abstract: An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
authors: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University , Singapore 637371, Singapore.
authors: Yuexia
authors: Y
authors: Zhang
authors: Yu
authors: Y
authors: Du
authors: Zhijian
authors: Z
authors: Huang
authors: Jianfeng
authors: J
authors: Xu
authors: Xingxing
authors: X
authors: Wu
authors: Yuhuang
authors: Y
authors: Wang
authors: Ming
authors: M
authors: Wang
authors: Song
authors: S
authors: Yang
authors: Richard D
authors: RD
authors: Webster
authors: Yonggui Robin
authors: YR
authors: Chi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D005609:Free Radicals / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006900:Hydroxylation; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D005609:Free Radicals; D006571:Heterocyclic Compounds; C030011:carbene; D008697:Methane