title: [Capsaicin in treatment of neuropathic pain].
abstract: Treatment of neuropathic pain (NP) is a serious medical problem. Antiepileptic drugs and antidepressants, used to relief pain, act on the central pain mechanisms and cause several side-effects, thus substantially restricting possibilities of their clinical application.At the same time, NP often has a peripheral component. Ligand-associated channels, including vanilloid receptors TRPV1, play a key role in the development of regional NP syndromes. Capsaicin, a component of chili pepper and several other plants, is a highly selective ligand of TRPV1 receptors and has long been used in treatment of pain syndromes. However, its using is limited by short-term action and relatively low efficacy. Recently it has been shown that the local use of single high doses of capsaicin during 30-60 min causes a marked stable(> 12 weeks) effect. The decrease in NP (>50%) is seen in about half of patients. Current studies will allow to single out groups of patients with the maximal treatment effect of capsaicin.
authors: P R
authors: PR
authors: Kamchatnov
authors: M A
authors: MA
authors: Evzelman
authors: B A
authors: BA
authors: Abusueva
authors: A I
authors: AI
authors: Volkov
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000627:therapeutic use*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D018689:Sensory System Agents / Q000627:therapeutic use*
chemical_list: D018689:Sensory System Agents; D002211:Capsaicin