title: Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds.
abstract: Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers' Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers' Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and reference values for 11 phthalate metabolites, 8 environmental phenols and parabens, and 24 volatile organic compound (VOC) metabolites. Reference values are also available for creatinine and the free forms of caffeine, theobromine, ibuprofen, nicotine, cotinine, and 3-hydroxycotinine. These are the first urine Certified Reference Materials characterized for metabolites of organic environmental contaminants. Noteworthy, the mass fractions of the environmental organic contaminants in the two SRMs are within the ranges reported in population survey studies such as the National Health and Nutrition Examination Survey (NHANES) and the Canadian Health Measures Survey (CHMS). These SRMs will be useful as quality control samples for ensuring compatibility of results among population survey studies and will fill a void to assess the accuracy of analytical methods used in studies monitoring human exposure to these organic environmental contaminants.
authors: Chemical Sciences Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA, michele.schantz@nist.gov.
authors: Michele M
authors: MM
authors: Schantz
authors: Bruce A
authors: BA
authors: Benner
authors: N Alan
authors: NA
authors: Heckert
authors: Lane C
authors: LC
authors: Sander
authors: Katherine E
authors: KE
authors: Sharpless
authors: Stacy S
authors: SS
authors: Vander Pol
authors: Y
authors: Y
authors: Vasquez
authors: M
authors: M
authors: Villegas
authors: Stephen A
authors: SA
authors: Wise
authors: K Udeni
authors: KU
authors: Alwis
authors: Benjamin C
authors: BC
authors: Blount
authors: Antonia M
authors: AM
authors: Calafat
authors: Zheng
authors: Z
authors: Li
authors: Manori J
authors: MJ
authors: Silva
authors: Xiaoyun
authors: X
authors: Ye
authors: Éric
authors: É
authors: Gaudreau
authors: Donald G
authors: DG
authors: Patterson
authors: Andreas
authors: A
authors: Sjödin
mesh_terms: D004785:Environmental Pollutants / Q000652:urine; D006801:Humans; D010226:Parabens / Q000032:analysis / Q000378:metabolism; D010636:Phenols / Q000378:metabolism / Q000652:urine*; D010795:Phthalic Acids / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism / Q000652:urine*; D012015:Reference Standards; D016482:Urinalysis / Q000379:methods / Q000592:standards*; D055549:Volatile Organic Compounds / Q000378:metabolism / Q000652:urine*
chemical_list: D004785:Environmental Pollutants; D010226:Parabens; D010636:Phenols; D010795:Phthalic Acids; D011084:Polycyclic Aromatic Hydrocarbons; D055549:Volatile Organic Compounds; C032279:phthalic acid
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