title: Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles.
abstract: Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9-1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications.
authors: Department of Chemistry, Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Malaysia.
authors: Ae
authors: A
authors: Mftah
authors: Catalysis Science and Technology Research Centre, Universiti Putra Malaysia, Selangor, Malaysia ; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Fatah H
authors: FH
authors: Alhassan
authors: Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
authors: Mothanna Sadiq
authors: MS
authors: Al-Qubaisi
authors: Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia.
authors: Mohamed Ezzat
authors: ME
authors: El Zowalaty
authors: Department of Chemical Engineering, Northeastern University, Boston, MA, USA ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors: Thomas J
authors: TJ
authors: Webster
authors: Solar Energy Research Institute, University Kebangsaan Malaysia, Selangor, Malaysia.
authors: Mohammed
authors: M
authors: Sh-Eldin
authors: Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Abdullah
authors: A
authors: Rasedee
authors: Catalysis Science and Technology Research Centre, Universiti Putra Malaysia, Selangor, Malaysia ; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia.
authors: Yun Hin
authors: YH
authors: Taufiq-Yap
authors: Department of Chemistry, Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Malaysia.
authors: Shah Samiur
authors: SS
authors: Rashid
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D015040:Zirconium; C028541:zirconium oxide
keywords: anticancer; antimicrobial; nanoparticles; sulphated zirconia
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