title: SNP rs4331426 in 18q11.2 is associated with susceptibility to tuberculosis among female Han Taiwanese.
abstract: A single nucleotide polymorphism (SNP) rs4331426 located in a gene-poor region on chromosome 18q11.2 has been associated with tuberculosis (TB) by genome-wide association studies in Ghana and Gambia. In this study, we analyzed the SNP rs4331426 for its association with the risk of TB in the Taiwanese population. The SNP rs4331426 was genotyped in a case-control design that included 377 Han Taiwanese (200 TB patients and 177 controls) and was associated with TB (marginally significant p = 0.078). An increasingly significant association was observed after adjusting for sex in the logistic regression analysis (p = 0.029). Furthermore, the G carrier (AG genotype) conferred the risk of TB in females (p = 0.011), but not in males. These findings indicate that the SNP rs4331426 associated with TB in the Han Taiwanese population, especially in females. Further investigations on its role and that of the genomic region surrounding it are warranted.
authors: Department of Internal Medicine, Tao Yuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
authors: Shih-Wei
authors: SW
authors: Lee
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors: Chia-Yin
authors: CY
authors: Lin
authors: Department of Internal Medicine, Tao Yuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
authors: Tzu-Yi
authors: TY
authors: Chuang
authors: Department of Internal Medicine, Tao Yuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
authors: Hsiu-Han
authors: HH
authors: Huang
authors: Department of Life Sciences, National Central University, Taoyuan, Taiwan. Electronic address: ykao@cc.ncu.edu.tw.
authors: Yung-Hsi
authors: YH
authors: Kao
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: lshwu@hotmail.com.
authors: Lawrence Shih-Hsin
authors: LS
authors: Wu
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000382:microbiology
keywords: rs4331426; single nucleotide polymorphism; tuberculosis