title: Overnight corneal swelling with high and low powered silicone hydrogel lenses.
abstract: OBJECTIVE
  To compare central corneal swelling after eight hours of sleep in eyes wearing four different silicone hydrogel lenses with three different powers.
  
  
  METHODS
  Twenty-nine neophyte subjects wore lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) and senofilcon A (Dk, 103) lenses in powers -3.00, -10.00 and +6.00 D on separate nights, in random order, and on one eye only. The contra-lateral eye (no lens) served as the control. Central corneal thickness was measured using a digital optical pachometer before lens insertion and immediately after lens removal on waking.
  
  
  RESULTS
  For the +6.00 D and -10.00 D, lotrafilcon A induced the least swelling and galyfilcon A the most. The +6.00 D power, averaged across lens materials, induced significantly greater central swelling than the -10.00 and -3.00 D (Re-ANOVA, p<0.001), (7.7±2.9% vs. 6.8±2.8% and 6.5±2.5% respectively) but there was no difference between -10.00 and -3.00 D. Averaged for power, lotrafilcon A induced the least (6.2±2.8%) and galyfilcon A the most (7.6±3.0%) swelling at the center (Re-ANOVA, p<0.001). Central corneal swelling with +6.00 D was significantly greater than -10.00 D lens power despite similar levels of average lens transmissibility of these two lens powers.
  
  
  CONCLUSIONS
  The differences in corneal swelling of the lens wearing eyes are consistent with the differences in oxygen transmission of the silicone hydrogel lenses. In silicone hydrogel lenses central corneal swelling is mainly driven by central lens oxygen transmissibility.
authors: Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada. Electronic address: ammoezzi@uwaterloo.ca.
authors: Amir M
authors: AM
authors: Moezzi
authors: Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
authors: Desmond
authors: D
authors: Fonn
authors: Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
authors: Jalaiah
authors: J
authors: Varikooty
authors: Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
authors: Trefford L
authors: TL
authors: Simpson
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D015715:Corneal Edema / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012826:Silicone Elastomers / Q000009:adverse effects; D055815:Young Adult
chemical_list: D020100:Hydrogels; D012826:Silicone Elastomers
keywords: Corneal swelling; Corneal thickness; Edema corneal; Optical pachometry; Oxygen transmissibility; Silicone hydrogel lenses; espesor de la córnea; lentes de hidrogel de silicona; paquimetría óptica; transmisibilidad del oxígeno
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