title: Gold-catalyzed multiple cascade reaction of 2-alkynylphenylazides with propargyl alcohols.
abstract: An unprecedented gold-catalyzed multiple cascade reaction between 2-alkynyl arylazides and alkynols has been developed, allowing for the step-economical synthesis of pyrroloindolone derivatives with a wide range of structural diversity. In this reaction, the gold complex participates in triple catalysis in tandem fashion. Moreover, the efficient chirality transfer from optically pure alkynol substrates enables facile access to chiral pyrroloindolone derivatives with two stereogenic centers, including a quaternary one, with excellent levels of optical purity.
authors: Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
authors: Nan
authors: N
authors: Li
authors: Tian-Yi
authors: TY
authors: Wang
authors: Liu-Zhu
authors: LZ
authors: Gong
authors: Liming
authors: L
authors: Zhang
keywords: carbenes; cascade reactions; chirality transfer; gold catalysis; sigmatropic rearrangement