title: Clinical relevance of multiple respiratory virus detection in adult patients with acute respiratory illness.
abstract: Because increasing numbers of nasopharyngeal swab specimens from adult patients with acute respiratory illness (ARI) are being tested by respiratory virus (RV) multiplex reverse transcriptase PCR (RVM-RT-PCR), multiple RV detection (MRVD) is being encountered more frequently. However, the clinical relevance of MRVD in adult patients has rarely been evaluated. The clinical characteristics of hospitalized adult patients with ARI and MRVD by RVM-RT-PCR tests were compared to those of patients with single RV detection (SRVD) during a single year at a tertiary care center. MRVD was observed in 26 of the 190 adult patients (13.7%). The patients with MRVD had a higher incidence of chronic lung disease than the patients with SRVD (34.6% versus 15.9%, crude odds ratio [OR]=2.81, 95% confidence interval [CI]=1.13 to 6.98, P=0.03). Although the former were more likely than the latter to receive mechanical ventilation (19.2% versus 6.7%, crude OR=3.31, 95% CI=1.05 to 10.47, P=0.049), the length of hospital stay (median, 7 versus 6.5 days; P=0.66), and the in-hospital mortality rate (7.7% versus 4.3%, crude OR=1.87, 95% CI=0.37 to 9.53, P=0.35) were not different between the two groups. In multivariate analysis, chronic lung disease was associated with MRVD (adjusted OR=3.08, 95% CI=1.12 to 8.46, P=0.03). In summary, it was not uncommon to encounter adult patients with ARI and MRVD by RVM-RT-PCR tests of nasopharyngeal swab specimens. MRVD was associated with chronic lung disease rather than the severity of the ARI.
authors: Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors: Seong-Ho
authors: SH
authors: Choi
authors: Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea drjwchung@cau.ac.kr.
authors: Jin-Won
authors: JW
authors: Chung
authors: Department of Laboratory Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors: Hye Ryoun
authors: HR
authors: Kim
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060085:Coinfection / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D056910:Republic of Korea / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology*; D014773:Virology / Q000379:methods; D014780:Viruses / Q000145:classification / Q000235:genetics*; D055815:Young Adult
references: Clin Infect Dis. 1997 Dec;25(6):1421-9
references: 9431390
references: J Clin Microbiol. 2010 Nov;48(11):3836-42
references: 20739481
references: Pediatr Infect Dis J. 2006 Apr;25(4):354-9
references: 16567989
references: Eur Respir J. 2011 Sep;38(3):739-42
references: 21885422
references: J Infect. 2011 Oct;63(4):260-6
references: 21546090
references: Crit Rev Clin Lab Sci. 2011 Sep-Dec;48(5-6):217-49
references: 22185616
references: PLoS One. 2012;7(2):e32174
references: 22389685
references: Braz J Infect Dis. 2012 Mar-Apr;16(2):180-3
references: 22552462
references: BMC Med. 2012;10:27
references: 22420941
references: Am J Respir Crit Care Med. 2012 Aug 15;186(4):325-32
references: 22700859
references: Curr Opin Pulm Med. 2013 Mar;19(2):125-32
references: 23361194
references: PLoS One. 2013;8(4):e60845
references: 23585856
references: Influenza Other Respir Viruses. 2013 Jul;7(4):559-66
references: 22883216
references: Diagn Microbiol Infect Dis. 2013 Jul;76(3):255-61
references: 23601453
references: Clin Microbiol Infect. 2013 Aug;19(8):772-7
references: 23020634
references: Influenza Other Respir Viruses. 2013 Nov;7(6):1079-87
references: 23078095
references: PLoS One. 2014;9(6):e99392
references: 24932493
references: Paediatr Respir Rev. 2014 Dec;15(4):363-70
references: 24361079
references: Korean J Intern Med. 2015 Jan;30(1):96-103
references: 25589841
references: Int J Tuberc Lung Dis. 2001 Oct;5(10):963-7
references: 11605892
references: J Med Virol. 2006 Nov;78(11):1498-504
references: 16998894
references: Arch Intern Med. 2007 Jul 9;167(13):1393-9
references: 17620533
references: J Clin Virol. 2010 Aug;48(4):239-45
references: 20646956
references: Pediatr Infect Dis J. 2005 Jul;24(7):605-10
references: 15999001