title: Cytokine profiles in Mycoplasma pneumoniae infection-associated hemophagocytic lymphohistiocytosis.
abstract: A 3-year-old boy with Mycoplasma pneumoniae infection associated with hemophagocytic lymphohistiocytosis (MP-HLH) presented with an elevated level of serum interleukin-12 (IL-12) and lower levels of interferon-γ and IL-10 compared to patients with Epstein-Barr virus infection associated with HLH (EBV-HLH). Unlike the patients with EBV-HLH, CD8+CD5lowHLA-DR++T cells were not detected in our pediatric patient. Thus, the pathophysiology of MP-HLH may differ from that of EBV-HLH.
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: yasutomi@u-fukui.ac.jp.
authors: Motoko
authors: M
authors: Yasutomi
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors: Shintaro
authors: S
authors: Okazaki
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors: Ikue
authors: I
authors: Hata
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors: Akihiko
authors: A
authors: Tanizawa
authors: Department of Pediatrics, Fukui Social Insurance Hospital, Fukui, Japan.
authors: Soichi
authors: S
authors: Tamamura
authors: Kawakita Pediatrics Clinic, Katsuyama, Fukui, Japan.
authors: Mikiko
authors: M
authors: Kawakita
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors: Yusei
authors: Y
authors: Ohshima
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D053765:Interleukin-12 Subunit p35 / Q000097:blood*; D007694:Killer Cells, Natural / Q000276:immunology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D009175:Mycoplasma Infections / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D009177:Mycoplasma pneumoniae / Q000276:immunology*
chemical_list: C508609:IL10 protein, human; C508858:IL12A protein, human; D053765:Interleukin-12 Subunit p35; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: CD8; Mycoplasma pneumoniae; cytokine; hemophagocytic lymphohistiocytosis