title: Regulation of signal transduction by reactive oxygen species in the cardiovascular system.
abstract: Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species (ROS) in normal physiological signaling has been elucidated. Signaling pathways modulated by ROS are complex and compartmentalized, and we are only beginning to identify the molecular modifications of specific targets. Here, we review the current literature on ROS signaling in the cardiovascular system, focusing on the role of ROS in normal physiology and how dysregulation of signaling circuits contributes to cardiovascular diseases, including atherosclerosis, ischemia-reperfusion injury, cardiomyopathy, and heart failure. In particular, we consider how ROS modulate signaling pathways related to phenotypic modulation, migration and adhesion, contractility, proliferation and hypertrophy, angiogenesis, endoplasmic reticulum stress, apoptosis, and senescence. Understanding the specific targets of ROS may guide the development of the next generation of ROS-modifying therapies to reduce morbidity and mortality associated with oxidative stress.
authors: From the Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA.
authors: David I
authors: DI
authors: Brown
authors: From the Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA. kgriend@emory.edu.
authors: Kathy K
authors: KK
authors: Griendling
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species
keywords: cardiovascular diseases; oxidative stress; reactive oxygen species; signal transduction
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