title: Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.
abstract: BACKGROUND
  Kinesins play a key role in the development and progression of many human cancers. The present study investigated the expression and clinical significance of kinesin family member 26B (KIF26B) in colorectal cancer (CRC).
  
  
  METHODS
  Using quantitative real-time PCR and Western blot analyses as well as immunohistochemical staining of a tissue microarray we examined KIF26B mRNA and protein levels in CRC tumor tissues and paired adjacent normal mucosa. Moreover, the effect of KIF26B knockdown on CRC cell proliferation was investigated using Cell Counting Kit-8 assays.
  
  
  RESULTS
  Expression of KIF26B was found to be elevated in CRC. Suppression of KIF26B inhibited CRC cell proliferation. Furthermore, upregulated expression of KIF26B was significantly correlated with tumor size (P = 0.020), American Joint Committee on Cancer (AJCC) stage (P = 0.018), T stage (P = 0.026), N stage (P = 0.013), and differentiation histology (P = 0.047). KIF26B was also shown to be an independent prognostic indicator of overall survival for CRC patients (HR 5.621; 95% CI 2.302-13.730; P < 0.001).
  
  
  CONCLUSIONS
  Our data indicate that KIF26B plays an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for CRC.
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. 1986wangjingtao@163.com.
authors: Jingtao
authors: J
authors: Wang
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. viviancui@163.com.
authors: Feifei
authors: F
authors: Cui
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. hnwangx@163.com.
authors: Xiao
authors: X
authors: Wang
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. doctoryingming@163.com.
authors: Yingming
authors: Y
authors: Xue
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. yufuchenjian@sina.com.
authors: Jian
authors: J
authors: Chen
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. shmuyuyang@gmail.com.
authors: Yang
authors: Y
authors: Yu
authors: Department of Pathology, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. luhuijun88885@163.com.
authors: Huijun
authors: H
authors: Lu
authors: Department of Pathology, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. 398245314@qq.com.
authors: Meng
authors: M
authors: Zhang
authors: Department of Pathology, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. tanghuamei@gmail.com.
authors: Huamei
authors: H
authors: Tang
authors: Department of General Surgery, First People's Hospital, Shanghai Jiao Tong Univerisity, 85 Wujin Road, Shanghai, 200080, China. pengzhp@hotmail.com.
authors: Zhihai
authors: Z
authors: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D016547:Kinesins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C583839:KIF26B protein, human; D016547:Kinesins
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