title: Antimicrobial and antioxidant activities and chemical characterization of essential oils of Thymusvulgaris, Rosmarinus officinalis, and Origanum majorana from northeastern México.
abstract: There have been no reports of antifungal activity and composition of extracts from Thymus vulgaris, Rosmarinus officinalis or Origanum majorana from northeastern México. Antifungal activity of these oils against Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum was measured by diffusion assay. Additionally, antibacterial and antioxidant activities were evaluated. Antibacterial activity against Staphylococcus aureus and Streptococcus pyogenes was examined by microdilution. Antioxidant activity was assessed by 2,2-difenil-1-picrilhidracil reduction test. The plant oils were characterized by both GC/MS and GC/FID. Oils of T. vulgaris and O. majorana showed growth inhibition activity against dermatophytes, especially T. vulgaris oil, which completely inhibited growth of all tested dermatophytes. The oils also showed bioactivity against bacteria, with minimum inhibitory concentration (MIC) values between 62.5 and 500 μg/mL. The antioxidant activity of the oils was low, with effective concentration (EC50) values <250μg/mL. The major components in the oils were as follows: T. vulgaris, o-cymene, μ-terpinene, thymol and carvacrol; R. officinalis, terpinen-4-ol and 1,8-cineole; O. majorana, terpinen-4-ol and thymol.
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Laura
authors: L
authors: Guerra-Boone
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Rocío
authors: R
authors: Alvarez-Román
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Rocío
authors: R
authors: Alvarez-Román
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Ricardo
authors: R
authors: Salazar-Aranda
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Anabel
authors: A
authors: Torres-Cirio
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Verónica Mayela
authors: VM
authors: Rivas-Galindo
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Noemí Waksman
authors: NW
authors: de-Torres
authors: Departamento de Microbiología. Av. Francisco I. Madero y Dr. Eduardo Aguirre Pequeño s/n, Col. Mitras Centro, Monterrey, Nuevo León, México.
authors: Gloria
authors: G
authors: González
authors: Departamento de Química Analítica, Universidad Autónoma de Nuevo León, Facultad de Medicina, México.
authors: Luis Alejandro
authors: LA
authors: Pérez-López
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D008800:Mexico; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*; D031341:Origanum / Q000737:chemistry*; D027542:Rosmarinus / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D009822:Oils, Volatile