title: Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery.
abstract: Large pore (4.6-7.6 nm) and well-dispersed benzene bridged mesoporous organosilica nanoparticles with uniform particle size of ≈50 nm are prepared via a biphasic approach. They can be directly used as nanocarriers without surface modification for the intracellular delivery of therapeutic proteins.
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Yannan
authors: Y
authors: Yang
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Yuting
authors: Y
authors: Niu
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Jun
authors: J
authors: Zhang
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Anand Kumar
authors: AK
authors: Meka
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Hongwei
authors: H
authors: Zhang
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Chun
authors: C
authors: Xu
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Chun Xiang Cynthia
authors: CX
authors: Lin
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Meihua
authors: M
authors: Yu
authors: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors: Chengzhong
authors: C
authors: Yu
mesh_terms: D001554:Benzene / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D061986:MCF-7 Cells; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D058726:Nanoconjugates / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure*; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition; D016062:Porosity; D012259:Ribonuclease, Pancreatic / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D058726:Nanoconjugates; D017646:Organosilicon Compounds; D012259:Ribonuclease, Pancreatic; D001554:Benzene
keywords: biphasic synthesis; large pores; mesoporous organosilica nanoparticles; protein delivery