title: Remission of recently diagnosed type 2 diabetes mellitus with weight loss and exercise.
abstract: OBJECTIVE
  To determine the rate of remission of recently diagnosed (<1 year) type 2 diabetes mellitus (T2DM) in overweight/obese individuals, with a 6-month program of weight loss and exercise.
  
  
  METHODS
  Subjects (N = 12) were overweight/obese (body mass index = 35.8 ± 4.3 kg/m), sedentary, and unfit ((Equation is included in full-text article.)O2peak = 20.7 ± 4.7 mL·kg·min) and recently (<1 year) diagnosed with T2DM. They were willing to participate in a lifestyle program of behavioral weight loss counseling and supervised exercise located at a cardiac rehabilitation program prior to consideration of diabetes medications. Glycated hemoglobin (HbA1c) level before and after the study intervention was the primary study outcome, along with secondary metabolic, fitness, and body composition variables.
  
  
  RESULTS
  Subjects had a baseline HbA1c of 6.5% to 8.0% (mean 6.8 ± 0.2). Subjects lost 9.7 ± 0.2 kg body weight (9%) and improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons unrelated to the lifestyle program. Eight of 10 completers (80%) went into partial T2DM remission, with the mean HbA1c decreasing from 6.8 ± 0.2% to 6.2 ± 0.3% (P < .001).
  
  
  CONCLUSIONS
  For individuals with recently diagnosed T2DM willing to undertake a formal lifestyle program, 80% of study completers and 67% of our total population achieved at least a partial T2DM remission at 6 months. Further study of this intervention at the time of diagnosis of T2DM with randomized controls and longer-term followup is warranted.
authors: Divisions of Cardiology (Dr Ades and Mr Savage), Endocrinology (Dr Marney), and Nutrition and Food Sciences (Dr Harvey and Ms Evans), University of Vermont Medical Center, Burlington, Vermont.
authors: Philip A
authors: PA
authors: Ades
authors: Patrick D
authors: PD
authors: Savage
authors: Annis M
authors: AM
authors: Marney
authors: Jean
authors: J
authors: Harvey
authors: Kimberly A
authors: KA
authors: Evans
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000628:therapy*; D004038:Diet, Reducing; D005081:Exercise Therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006293:Health Promotion / Q000379:methods; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000150:complications* / Q000628:therapy*; D015431:Weight Loss
chemical_list: D006442:Glycated Hemoglobin
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