title: Sleep quality change after upper airway surgery in obstructive sleep apnea: Electrocardiogram-based cardiopulmonary coupling analysis.
abstract: OBJECTIVE
  To test the effect of upper airway surgery on sleep quality in adults with obstructive sleep apnea (OSA) and the potential usefulness of electrocardiogram (ECG)-based cardiopulmonary coupling (CPC) analysis as metrics of sleep quality.
  
  
  METHODS
  Retrospective outcome research.
  
  
  METHODS
  A total of 62 consecutive adult patients with OSA, consisting of 36 with successful and 26 with unsuccessful outcomes, were included in the study. Mean age was 37.7 ± 8.9 years, and body mass index (BMI, kg/m(2) ) was 26.9 ± 2.3. We compared clinical characteristics (age, BMI, and Epworth Sleepiness Scale [ESS]), sleep (sleep efficiency, stage non-rapid eye movement [N]1, N2, N3, rapid eye movement, and arousal index [ArI]), respiratory (apnea index [AI], apnea-hypopnea index [AHI], and minimum arterial oxygen saturation [SaO2 ]), and CPC (high-frequency coupling [HFC], low frequency coupling [LFC], very-low-frequency coupling, and elevated low-frequency coupling [e-LFC]) parameters between the success and nonsuccess groups before and after surgery. Surgical success was defined when the postoperative AHI was both <20 per hour and 50% of the preoperative value.
  
  
  RESULTS
  Sleep quality measured by CPC analysis improved significantly (HFC, P = .001; LFC, P = .002; e-LFC, P = .003), along with parallel reduction in ESS, respiratory parameters (AHI, AI, minimum SaO2 ), and sleep fragmentation (ArI) in the group with surgical success after upper airway surgery.
  
  
  CONCLUSIONS
  Successful upper airway surgery can improve objective sleep quality in adult patients with OSA. CPC metrics of sleep quality are potentially useful to monitor therapeutic responses during long-term postoperative follow-up, as the ECG-based analysis is available as a standalone option outside laboratory polysomnography.
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Ji Ho
authors: JH
authors: Choi
authors: Division of Pulmonary, Critical Care and Sleep Medicine , Beth Israel Deaconess Medical Center, Boston, Massachusetts, U.S.A.
authors: Robert J
authors: RJ
authors: Thomas
authors: Department of Psychology , Sungshin Women's University, Seoul, Korea.|Department of Psychiatry , Stanford University, Palo Alto, California, U.S.A.
authors: Soo Yeon
authors: SY
authors: Suh
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Il Ho
authors: IH
authors: Park
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Tae Hoon
authors: TH
authors: Kim
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Sang Hag
authors: SH
authors: Lee
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Heung Man
authors: HM
authors: Lee
authors: Department of Neurology , Bundang Clinical Neuroscience Institute, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Chang-Ho
authors: CH
authors: Yun
authors: Department of Otorhinolaryngology-Head and Neck Surgery , College of Medicine, Korea University, Seoul, Korea.
authors: Seung Hoon
authors: SH
authors: Lee
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004562:Electrocardiography / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D058753:Laryngoplasty / Q000379:methods*; D008991:Monitoring, Physiologic; D017286:Polysomnography; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D012895:Sleep, REM / Q000502:physiology*
keywords: Cardiopulmonary coupling; obstructive sleep apnea; polysomnography; sleep quality; surgery