title: Functions of the influenza A virus NS1 protein in antiviral defense.
abstract: Influenza A viruses counteract host antiviral activities, especially the production of interferons (IFNs) and the activities of IFN-induced proteins that inhibit virus replication. The viral NS1 protein is largely responsible for countering these IFN antiviral responses, but there are functional differences between the NS1 proteins of different virus strains. The NS1 protein inhibits IFN production by two mechanisms: inhibition of the activation of IRF3 and IFN transcription; and inhibition of the processing of IFN pre-mRNAs. The NS1 proteins of several virus strains do not inhibit IRF3 activation, and the NS1 protein of one virus strain does not inhibit the processing of IFN pre-mRNAs. Many issues remain concerning the mechanisms of action of the various NS1 proteins in countering the IFN response.
authors: Department of Molecular Biosciences, Center for Infectious Disease, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA. Electronic address: rkrug@austin.utexas.edu.
authors: Robert M
authors: RM
authors: Krug
mesh_terms: D054884:Host-Pathogen Interactions; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000502:physiology*; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D050838:Interferon Regulatory Factor-3 / Q000378:metabolism; D007372:Interferons / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D014158:Transcription, Genetic; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D014779:Virus Replication
chemical_list: C085820:INS1 protein, influenza virus; C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D012322:RNA Precursors; D017361:Viral Nonstructural Proteins; D007372:Interferons
references: J Virol. 2006 Apr;80(8):3957-65
references: 16571812
references: Nat Immunol. 2004 Jul;5(7):730-7
references: 15208624
references: Nat Struct Biol. 1997 Nov;4(11):891-5
references: 9360601
references: Nat Struct Biol. 1997 Nov;4(11):896-9
references: 9360602
references: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4864-9
references: 9560194
references: Pharmacol Ther. 1998 Apr;78(1):29-46
references: 9593328
references: Mol Cell. 1998 Jun;1(7):991-1000
references: 9651582
references: J Biol Chem. 1999 Feb 5;274(6):3797-803
references: 9920933
references: RNA. 1999 Feb;5(2):195-205
references: 10024172
references: Proc Natl Acad Sci U S A. 2006 May 2;103(18):7100-5
references: 16627618
references: Virology. 2006 May 25;349(1):13-21
references: 16466763
references: J Virol. 2007 Jan;81(2):514-24
references: 17079289
references: J Virol. 2007 Mar;81(5):2221-30
references: 17166899
references: Am J Respir Cell Mol Biol. 2007 Mar;36(3):263-9
references: 17053203
references: Cell Microbiol. 2007 Apr;9(4):930-8
references: 17140406
references: Virology. 2007 Jun 20;363(1):236-43
references: 17320139
references: J Virol. 2007 Jun;81(11):5995-6006
references: 17376915
references: J Virol. 2007 Jul;81(13):7011-21
references: 17442719
references: J Virol. 2007 Dec;81(23):12720-9
references: 17804500
references: Virology. 2008 Aug 15;378(1):1-5
references: 18585749
references: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13093-8
references: 18725644
references: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16743-8
references: 18948594
references: Immunol Rev. 2009 Jan;227(1):75-86
references: 19120477
references: Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):11-7
references: 19153461
references: Cell Res. 2009 Feb;19(2):187-95
references: 18813227
references: Science. 2009 Feb 20;323(5917):1070-4
references: 19119185
references: Cell Host Microbe. 2009 May 8;5(5):439-49
references: 19454348
references: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
references: 20080593
references: Cell. 2010 Apr 16;141(2):315-30
references: 20403326
references: J Virol. 2010 Jul;84(14):6909-22
references: 20444891
references: Virology. 2010 Dec 20;408(2):146-58
references: 20934196
references: Cell Host Microbe. 2010 Dec 16;8(6):496-509
references: 21147464
references: PLoS One. 2011;6(3):e17946
references: 21464929
references: J Virol. 2011 Jul;85(14):7048-58
references: 21593152
references: J Biol Chem. 2011 Jul 22;286(29):26050-60
references: 21622573
references: Cell. 2011 Oct 14;147(2):409-22
references: 22000018
references: Cell. 2011 Oct 14;147(2):423-35
references: 22000019
references: J Virol. 2012 Oct;86(19):10733-8
references: 22837208
references: Nature. 2012 Mar 22;483(7390):428-33
references: 22419161
references: J Virol. 2007 Aug;81(15):8112-21
references: 17522219
references: PLoS Pathog. 2012;8(11):e1003059
references: 23209422
references: J Infect Dis. 2014 Jul 15;210(2):214-23
references: 24493823
references: J Virol. 2014 Oct;88(20):12146-51
references: 25078692
references: J Virol. 2000 Sep;74(17):7989-96
references: 10933707
references: J Virol. 2000 Dec;74(24):11566-73
references: 11090154
references: Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10096-101
references: 12114540
references: Virology. 2003 Mar 15;307(2):386-95
references: 12667806
references: Biochemistry. 2004 Feb 24;43(7):1950-62
references: 14967035
references: J Virol. 1988 Aug;62(8):3020-6
references: 2969057