title: Statistical context shapes stimulus-specific adaptation in human auditory cortex.
abstract: Stimulus-specific adaptation is the phenomenon whereby neural response magnitude decreases with repeated stimulation. Inconsistencies between recent nonhuman animal recordings and computational modeling suggest dynamic influences on stimulus-specific adaptation. The present human electroencephalography (EEG) study investigates the potential role of statistical context in dynamically modulating stimulus-specific adaptation by examining the auditory cortex-generated N1 and P2 components. As in previous studies of stimulus-specific adaptation, listeners were presented with oddball sequences in which the presentation of a repeated tone was infrequently interrupted by rare spectral changes taking on three different magnitudes. Critically, the statistical context varied with respect to the probability of small versus large spectral changes within oddball sequences (half of the time a small change was most probable; in the other half a large change was most probable). We observed larger N1 and P2 amplitudes (i.e., release from adaptation) for all spectral changes in the small-change compared with the large-change statistical context. The increase in response magnitude also held for responses to tones presented with high probability, indicating that statistical adaptation can overrule stimulus probability per se in its influence on neural responses. Computational modeling showed that the degree of coadaptation in auditory cortex changed depending on the statistical context, which in turn affected stimulus-specific adaptation. Thus the present data demonstrate that stimulus-specific adaptation in human auditory cortex critically depends on statistical context. Finally, the present results challenge the implicit assumption of stationarity of neural response magnitudes that governs the practice of isolating established deviant-detection responses such as the mismatch negativity.
authors: Max Planck Research Group "Auditory Cognition," Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; and bjoern.herrmann@outlook.com.
authors: Björn
authors: B
authors: Herrmann
authors: Max Planck Research Group "Auditory Cognition," Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; and.
authors: Molly J
authors: MJ
authors: Henry
authors: Department of Psychology, Michigan State University, East Lansing, Michigan.
authors: Elisa Kim
authors: EK
authors: Fromboluti
authors: Department of Psychology, Michigan State University, East Lansing, Michigan.
authors: J Devin
authors: JD
authors: McAuley
authors: Max Planck Research Group "Auditory Cognition," Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; and.
authors: Jonas
authors: http://orcid.org/0000-0002-7619-0459
authors: J
authors: Obleser
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008959:Models, Neurological; D011336:Probability; D055815:Young Adult
keywords: auditory processing; event-related potentials; stimulus statistics; stimulus-specific adaptation
references: Front Psychol. 2013 Oct 21;4:717
references: 24155730
references: J Physiol. 2014 Aug 15;592(16):3371-81
references: 24907308
references: Nat Neurosci. 2013 Jun;16(6):724-9
references: 23603708
references: Biol Psychol. 2006 Jun;72(3):333-43
references: 16446023
references: J Neurophysiol. 2013 Apr;109(8):2086-96
references: 23343904
references: Neural Comput. 1995 Nov;7(6):1129-59
references: 7584893
references: Trends Neurosci. 2007 Dec;30(12):653-61
references: 17981345
references: Neurosci Lett. 2007 Jan 22;412(1):1-5
references: 17197084
references: Neuron. 2009 Mar 12;61(5):774-85
references: 19285473
references: J Neurophysiol. 2013 Aug;110(4):973-83
references: 23719212
references: Comput Intell Neurosci. 2011;2011:156869
references: 21253357
references: Curr Opin Neurobiol. 2007 Aug;17(4):423-9
references: 17714934
references: Neuron. 2012 Nov 8;76(3):603-15
references: 23141071
references: Neurosci Lett. 1998 Feb 6;242(1):49-52
references: 9510002
references: Brain Res Cogn Brain Res. 2002 May;13(3):393-405
references: 11919003
references: PLoS One. 2011;6(8):e23369
references: 21853120
references: J Neurosci. 2009 Apr 29;29(17):5483-93
references: 19403816
references: Electroencephalogr Clin Neurophysiol. 1978 Aug;45(2):198-210
references: 78830
references: Front Neural Circuits. 2013 Jan 17;6:89
references: 23335883
references: Neuroimage. 1999 Mar;9(3):330-6
references: 10075902
references: Psychophysiology. 1998 Mar;35(2):211-24
references: 9529947
references: J Neurosci. 2009 Nov 4;29(44):13797-808
references: 19889991
references: Neuron. 2006 Sep 21;51(6):845-59
references: 16982428
references: Clin Neurophysiol. 2012 Mar;123(3):507-12
references: 21839676
references: J Neurosci. 2008 Dec 10;28(50):13629-39
references: 19074036
references: Clin Neurophysiol. 2007 Dec;118(12):2544-90
references: 17931964
references: IEEE Trans Biomed Circuits Syst. 2011 Oct;5(5):413-9
references: 23852174
references: Neuron. 2000 Jul;27(1):15-21
references: 10939327
references: J Neurophysiol. 2004 Feb;91(2):604-12
references: 14762146
references: Neurosci Lett. 2011 Feb 25;490(2):116-20
references: 21185355
references: J Neurosci. 2014 Feb 26;34(9):3303-19
references: 24573289
references: Nature. 2001 Aug 23;412(6849):787-92
references: 11518957
references: Psychophysiology. 2001 Jul;38(4):723-7
references: 11446587
references: Hear Res. 2013 Oct;304:128-36
references: 23876524
references: Psychophysiology. 1987 Jul;24(4):375-425
references: 3615753
references: Nat Neurosci. 2003 Apr;6(4):391-8
references: 12652303
references: Clin Neurophysiol. 2004 Apr;115(4):732-44
references: 15003751
references: Nat Neurosci. 2005 Dec;8(12):1684-9
references: 16286934
references: Electroencephalogr Clin Neurophysiol. 1989 May-Jun;74(3):217-27
references: 2470578
references: Neuron. 2011 Oct 20;72(2):231-43
references: 22017986
references: Nat Rev Neurosci. 2010 Jul;11(7):474-89
references: 20531421
references: J Neurosci. 2011 Oct 5;31(40):14142-50
references: 21976499
references: Neuroimage. 2003 Oct;20(2):1020-5
references: 14568471
references: Psychophysiology. 2008 Jan;45(1):60-9
references: 17868262
references: Int J Psychophysiol. 1998 Dec;31(1):51-68
references: 9934621
references: J Neurosci. 2012 Nov 7;32(45):15747-58
references: 23136414
references: Exp Psychol. 2004;51(4):249-57
references: 15620226
references: PLoS Comput Biol. 2013;9(3):e1002999
references: 23555230
references: J Acoust Soc Am. 1968 Oct;44(4):945-50
references: 5683660
references: Neuroimage. 2007 Aug 15;37(2):561-71
references: 17596966
references: J Neurophysiol. 2013 Dec;110(12):2679-88
references: 24047909
references: Behav Brain Res. 1996 Apr;76(1-2):191-7
references: 8734053
references: J Neurosci. 2009 Jun 3;29(22):7359-63
references: 19494157
references: J Neurosci. 2014 Jan 1;34(1):327-31
references: 24381293
references: Science. 1997 Jan 10;275(5297):220-4
references: 8985017
references: Biol Cybern. 2014 Oct;108(5):655-63
references: 24477619
references: Neuroreport. 1996 Nov 25;7(18):3005-8
references: 9116228
references: Nature. 2008 Apr 24;452(7190):956-60
references: 18344978
references: J Cogn Neurosci. 1993 Summer;5(3):363-70
references: 23972223
references: Psychophysiology. 2010 Jan 1;47(1):66-122
references: 19686538
references: J Vis. 2012;12(6). pii: 32. doi: 10.1167/12.6.32
references: 22728681
references: J Neurosci. 2008 Jun 18;28(25):6430-8
references: 18562614
references: Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14935-40
references: 25267634
references: J Neurosci. 2010 Oct 6;30(40):13362-6
references: 20926662
references: Atten Percept Psychophys. 2013 Oct;75(7):1547-58
references: 23801322
references: J Neurosci. 2011 Jun 29;31(26):9708-22
references: 21715636
references: Front Neurosci. 2007 Oct 15;1(1):197-209
references: 18982129
references: J Comput Neurosci. 1999 Mar-Apr;6(2):99-120
references: 10333158
references: Brain Res. 1992 Feb 14;572(1-2):236-41
references: 1611518
references: Trends Cogn Sci. 2009 Dec;13(12):532-40
references: 19828357
references: Neuron. 2011 Jun 23;70(6):1178-91
references: 21689603
references: Neuron. 2010 Jun 24;66(6):937-48
references: 20620878
references: Neuron. 2000 Jun;26(3):695-702
references: 10896164
references: Psychophysiology. 2014 Feb;51(2):111-23
references: 24423134
references: Neuroimage. 2011 Sep 15;58(2):630-9
references: 21726651
references: PLoS One. 2012;7(3):e34297
references: 22479591
references: Psychophysiology. 1997 May;34(3):308-16
references: 9175445
references: Neuroreport. 1998 Apr 20;9(6):1115-9
references: 9601678
references: Nature. 2012 Aug 16;488(7411):343-8
references: 22878717
references: J Neurosci. 2004 Nov 17;24(46):10440-53
references: 15548659
references: J Neurophysiol. 2012 Jul;108(1):69-82
references: 22457465
references: Neurol Clin Neurophysiol. 2004;2004:20
references: 16012601
references: Electroencephalogr Clin Neurophysiol. 1988 Jun;69(6):523-31
references: 2453329
references: J Physiol. 2014 Feb 15;592(4):729-43
references: 24099802
references: Brain Res Rev. 2010 Sep;64(1):123-36
references: 20298716
references: Acta Psychol (Amst). 1978 Jul;42(4):313-29
references: 685709
references: J Neurosci. 2009 Nov 4;29(44):13837-49
references: 19889995
references: Electroencephalogr Clin Neurophysiol. 1982 Nov;54(5):561-9
references: 6181979