title: Quantitative measurement of oxygen extraction fraction by MRI in patients with cerebrovascular disease: pre- and post-surgery.
abstract: OBJECTIVE
  We aimed to evaluate cerebral hemodynamic status of preoperative and postoperative revascularization treatment by oxygen extraction fraction (OEF)-magnetic resonance imaging (MRI) in patients with severe cerebrovascular stenosis or occlusive disease.
  
  
  METHODS
  This study enrolled 9 symptomatic patients with severe cerebrovascular disease and 9 age-matched normal volunteers. Cerebral blood flow (CBF) and OEF were determined in all subjects by functional MRI. Brain regions with elevated OEF above normal range were defined in the patients preoperatively. The values of pre- and postoperative OEF in these regions were compared.
  
  
  RESULTS
  A total of 16 regions of interest (ROIs) had elevated OEF before the vascular surgery, with relative CBF (rCBF) values ranging from 0.2 to 1.0. OEF decreased to normal range in 15 ROIs postoperatively, which indicated hemodynamic improvement in these regions. The OEF value of the high-OEF group (preoperative OEF value ranged from 0.365 to 0.400) had a significant decrease compared with those of the low-OEF group (preoperative OEF value ranged from 0.350 to 0.365), which showed an a statistical difference (p = 0.001).
  
  
  CONCLUSIONS
  OEF was elevated in patients with severe ischemic cerebrovascular disease, and decreased after successful revascularization. OEFMRI can provide quantitative information for evaluating the hemodynamic status and selecting the candidates suitable for revascularization.
authors: China-Japan Friendship Hospital, Department of Radiology, Beijing, China.
authors: Sheng
authors: S
authors: Xie
authors: Jiangxi
authors: J
authors: Xiao
authors: Hongzhou
authors: H
authors: Duan
authors: Lei
authors: L
authors: Fu
authors: Dapeng
authors: D
authors: Mo
authors: Xiaodong
authors: X
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D057234:Preoperative Period; D011877:Radionuclide Imaging; D012720:Severity of Illness Index
chemical_list: D010100:Oxygen