title: A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.
abstract: BACKGROUND
  Individuals infected with chikungunya virus (CHIKV) normally exhibit a variety of clinical manifestations during the acute phase of infection. However, studies in different patient cohorts have revealed that disease manifestations vary in frequency.
  
  
  METHODS
  Disease profiles between patients with acute CHIKV-infection and febrile patients without CHIKV were compared and examined to determine whether any clinical presentations were associated with the clinical outcome of CHIKV infection. Circulatory immune mediators profiles were then characterized and compared with data from 14 independent patient cohort studies. The particular immune mediator signature that defines acute CHIKV infection was determined.
  
  
  RESULTS
  Our findings revealed a specific pattern of clinical presentations of joint-specific arthralgia from this CHIKV cohort. More importantly, we identified an immune mediator signature dominated by proinflammatory cytokines, which include interferon α and γ and interleukin 2, 2R, 6, 7, 12, 15, 17, and 18, across different patient cohorts of CHIKV load associated with arthralgia.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study that associated levels of CHIKV load with arthralgia as an indicator of acute CHIKV infection. Importantly, our findings also revealed specific immune mediator signatures that can be used to better define CHIKV infection.
authors: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.
authors: Terk-Shin
authors: TS
authors: Teng
authors: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.
authors: Yiu-Wing
authors: YW
authors: Kam
authors: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis.
authors: Bernett
authors: B
authors: Lee
authors: Environmental Health Institute, National Environment Agency, Singapore.
authors: Hapuarachchige Chanditha
authors: HC
authors: Hapuarachchi
authors: Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
authors: Abeyewickreme
authors: A
authors: Wimal
authors: Environmental Health Institute, National Environment Agency, Singapore.
authors: Lee-Ching
authors: LC
authors: Ng
authors: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis Institute of Infection and Global Health, University of Liverpool, United Kingdom.
authors: Lisa F P
authors: LF
authors: Ng
mesh_terms: D018771:Arthralgia / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis*; D065632:Chikungunya Fever / Q000276:immunology*; D002646:Chikungunya virus / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D019562:Viral Load
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: acute infection; chemokines; chikungunya virus; cytokines; meta-analysis
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