title: Chorea due to diabetic hyperglycemia and uremia: distinct clinical and imaging features.
abstract: This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C-NKH) in comparison with patients with chorea associated with uremia (C-URE). We retrospectively analyzed the clinical data of consecutive 10 C-NKH and five C-URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C-NKH (70% vs. 30%) and C-URE (80% vs. 20%) compared with men. The C-NKH patients demonstrated T1-hyperintense and inhomogeneous lesions in the basal ganglia, whereas C-URE patients demonstrated T2-hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C-NKH patients than in C-URE patients (4.4 ± 2.6 d vs. 73.8 ± 14.2 d, respectively; P = 0.005). The clinical and imaging features are remarkably different between C-NKH and C-URE patients, suggesting distinct pathogenic mechanisms.
authors: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors: Young Jin
authors: YJ
authors: Kim
authors: Sang Joon
authors: SJ
authors: Kim
authors: Juyeon
authors: J
authors: Kim
authors: Mi-Jung
authors: MJ
authors: Kim
authors: Ki-Ju
authors: KJ
authors: Kim
authors: Hyukjun
authors: H
authors: Yoon
authors: Sung Reul
authors: SR
authors: Kim
authors: Sun Ju
authors: SJ
authors: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002819:Chorea / Q000175:diagnosis / Q000209:etiology*; D048909:Diabetes Complications / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014511:Uremia / Q000150:complications*
keywords: Chorea; diabetes; hyperglycemia; magnetic resonance imaging; uremia