title: Bladder cancer: molecular determinants of personalized therapy.
abstract: Several molecular and genetic studies have provided new perspectives on the histologic classification of bladder tumors. Recent developments in the field of molecular mutational pathway analyses based on next generation sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated taxonomy of bladder cancer. All these changes are behind the use of non-traditional approach to therapy of bladder cancer patients and are ready to change our daily practice of uro-oncology. The observed correlation of some molecular alterations with tumor behavior and the identification of their targets at cellular level might support the use of molecular changes together with morphological data to develop new clinical and biological strategies to manage patients with urothelial cancer. The current review provides comprehensive data to support personalized therapy for bladder cancer based on an integrated approach including pathologic and clinical features and molecular biology.
authors: Antonio
authors: A
authors: Lopez-Beltran
authors: Matteo
authors: M
authors: Santoni
authors: Francesco
authors: F
authors: Massari
authors: Chiara
authors: C
authors: Ciccarese
authors: Giampaolo
authors: G
authors: Tortora
authors: Liang
authors: L
authors: Cheng
authors: Holger
authors: H
authors: Moch
authors: Marina
authors: M
authors: Scarpelli
authors: Carlos
authors: C
authors: Reymundo
authors: Department of Surgery and Pathology, Cordoba University Medical School, Cordoba, Spain and Champalimaud Clinical Center, Lisbon, Portugal. em1lobea@gmail.com.
authors: Rodolfo
authors: R
authors: Montironi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009154:Mutation; D057285:Precision Medicine; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019459:Urothelium / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents