title: Gold nanorod-photosensitizer complex obtained by layer-by-layer method for photodynamic/photothermal therapy in vitro.
abstract: Gold nanorod (GNR)-photosensitizer (PS) complex was prepared using anionic PS (sodium salt of purpurin-18) and cationic poly(allylamine hydrochloride) by layer-by-layer method, and was characterized by transmission electron microscopy, UV-vis spectroscopy, and zeta potential. The GNR-PS complex is a promising agent for synergistic (photothermal and photodynamic) therapy (PTT/PDT), in which PTT generates heat as well as operates the PS release which maximize the following PDT activity. The combined dual therapy, PTT followed by PDT, exhibits a significantly higher photocytotoxicity result based on synergistic effect of hyperthermia from PTT as well as singlet oxygen photogeneration from PDT.
authors: Photodynamic Therapy Institute and School of Nano System Engineering, Inje University, 197 Injero, Gimhae, Gyeongnam 621-749 (Republic of Korea).
authors: Seung Beom
authors: SB
authors: Kim
authors: Tae Heon
authors: TH
authors: Lee
authors: Il
authors: I
authors: Yoon
authors: Young Key
authors: YK
authors: Shim
authors: Woo Kyoung
authors: WK
authors: Lee
mesh_terms: D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D053768:Metal Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D006046:Gold
keywords: drug delivery; drug release; gold nanorods; photodynamic therapy; photothermal therapy; synergistic therapy