title: Plasmablastic lymphoma of the stomach with C-MYC rearrangement in an immunocompetent young adult: a case report.
abstract: Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm mostly described in human immunodeficiency virus-infected patients. Herein, we described a case of PBL presenting as gastric mass in a 21-year-old young adult without known immunodeficiency. The histological examination of the specimen showed a diffuse proliferation of round- to oval-shaped large cells with scant cytoplasm, and prominent nucleoli. The neoplasm stained positively for CD45, CD38, MUM1, and Vs38C, but typical B-cell and T-cell markers (PAX5, CD20, CD79a, and CD3) were absent. The proliferative index (Ki-67) was about 95%. And the neoplastic cells diffusely expressed the c-myc protein. Epstein-Barr virus-encoded RNA in situ hybridization was negative. Molecular genetic study via interphase fluorescence in situ hybridization disclosed the rearrangement involving c-myc gene. Awareness of this distinctive lymphoma can prevent misdiagnosis by the clinicians and/or the pathologists.
authors: From the Department of Pathology, School of medical science, Peking University Health Science Center, Beijing, China (XH, YZ, ZG).
authors: Xin
authors: X
authors: Huang
authors: Yanping
authors: Y
authors: Zhang
authors: Zifen
authors: Z
authors: Gao
mesh_terms: D017809:Fatal Outcome; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D007121:Immunocompetence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology*; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
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