title: Trifolium-like Platinum Nanoparticle-Mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model.
abstract: Bone metastasis is a frequent and fatal complication of cancer that lacks effective clinical treatment. Photothermal therapy represents a new strategy for the destruction of multiple cancers. In this study, trifolium-like platinum nanoparticles (TPNs) with small size and excellent photothermal conversion property are prepared via a facile and green method. TPNs show minimal cytotoxicity on normal cell lines and kill cancer cells upon exposure to a near-infrared light. These nanoparticles effectively inhibit tumor growth and prevent osteolysis in a bone metastasis model. This study offers a promising strategy in the treatment of bone metastasis.
authors: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200062, P. R. China.
authors: Changping
authors: C
authors: Wang
authors: Xiaopan
authors: X
authors: Cai
authors: Jishen
authors: J
authors: Zhang
authors: Xinyu
authors: X
authors: Wang
authors: Yu
authors: Y
authors: Wang
authors: Huyifeng
authors: H
authors: Ge
authors: Wangjun
authors: W
authors: Yan
authors: Quan
authors: Q
authors: Huang
authors: Jianru
authors: J
authors: Xiao
authors: Qiang
authors: Q
authors: Zhang
authors: Yiyun
authors: Y
authors: Cheng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001835:Body Weight; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D002460:Cell Line; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D021621:Imaging, Three-Dimensional; D007259:Infrared Rays; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D010014:Osteolysis / Q000503:physiopathology*; D010777:Photochemistry; D010789:Phototherapy / Q000379:methods*; D010984:Platinum / Q000737:chemistry*; D017671:Platinum Compounds / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D029921:Trifolium / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D017671:Platinum Compounds; C002999:chloroplatinic acid; D010984:Platinum; D011205:Povidone
keywords: bone metastasis; osteolysis; photothermal cancer therapy; platinum nanoparticles