title: MicroRNA-204 targets signal transducer and activator of transcription 5 expression and inhibits proliferation of B-cell lymphoma cells.
abstract: The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR‑204 in B‑cell lymphoma. The present study demonstrated that miR‑204 is downregulated in B‑cell lymphoma. Using in vitro studies, overexpression of miR‑204 was shown to inhibit growth in Daudi and Raji B‑cell lymphoma cell lines. Furthermore, miR‑204 could bind the 3'‑untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes B‑cell lymphoma oncogenesis. Re‑introduction of STAT5 reversed the antiproliferative roles of miR‑204, confirming the specific importance of STAT5 for miR‑204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of B‑cell lymphoma.
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Li
authors: L
authors: Wu
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Yong
authors: Y
authors: Li
authors: Department of Hematology, Guiyang College of Medicine, Guiyang, Guizhou 550004, P.R. China.
authors: Jian-Min
authors: JM
authors: Fan
authors: Department of Hematology, Guiyang College of Medicine, Guiyang, Guizhou 550004, P.R. China.
authors: Zhi-Min
authors: ZM
authors: Zhang
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Jin-Ling
authors: JL
authors: Ouyang
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Ting-Ting
authors: TT
authors: Ni
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Hai-Xia
authors: HX
authors: Wu
authors: Department of Oncology, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P.R. China.
authors: Hang
authors: H
authors: Li
mesh_terms: D020413:3' Untranslated Regions; D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D015536:Down-Regulation; D059585:G1 Phase Cell Cycle Checkpoints; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000378:metabolism; D050799:STAT5 Transcription Factor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D020413:3' Untranslated Regions; C549404:MIRN204 microRNA, human; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense; D050799:STAT5 Transcription Factor