title: A central neural pathway controlling odor tracking in Drosophila.
abstract: Chemotaxis is important for the survival of most animals. How the brain translates sensory input into motor output beyond higher olfactory processing centers is largely unknown. We describe a group of excitatory neurons, termed Odd neurons, which are important for Drosophila larval chemotaxis. Odd neurons receive synaptic input from projection neurons in the calyx of the mushroom body and project axons to the central brain. Functional imaging shows that some of the Odd neurons respond to odor. Larvae in which Odd neurons are silenced are less efficient at odor tracking than controls and sample the odor space more frequently. Larvae in which the excitability of Odd neurons is increased are better at odor intensity discrimination and odor tracking. Thus, the Odd neurons represent a distinct pathway that regulates the sensitivity of the olfactory system to odor concentrations, demonstrating that efficient chemotaxis depends on processing of odor strength downstream of higher olfactory centers.
authors: Medical Research Council Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, United Kingdom, and.
authors: Gemma
authors: G
authors: Slater
authors: Medical Research Council Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, United Kingdom, and.
authors: Peter
authors: P
authors: Levy
authors: Institute of Pharmaceutical Science, King's College, London SE1 9NH, United Kingdom.
authors: K L Andrew
authors: KL
authors: Chan
authors: Medical Research Council Centre for Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, United Kingdom, and camilla.larsen@kcl.ac.uk.
authors: Camilla
authors: http://orcid.org/0000-0003-1138-3476
authors: C
authors: Larsen
mesh_terms: D000818:Animals; D002633:Chemotaxis; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D007814:Larva / Q000502:physiology; D024521:Mushroom Bodies / Q000502:physiology; D009812:Odorants; D009833:Olfactory Pathways / Q000166:cytology / Q000502:physiology*; D018034:Olfactory Receptor Neurons / Q000502:physiology; D012903:Smell; D013569:Synapses / Q000502:physiology
keywords: Drosophila; behavior; chemotaxis; mushroom body; olfaction
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