title: Incidence of dengue virus infection in school-aged children in Puerto Rico: a prospective seroepidemiologic study.
abstract: Dengue is a potentially fatal acute febrile illness caused by the mosquito-borne dengue viruses (DENV-1 to -4). To estimate DENV seroincidence in school-aged children, a 1-year prospective cohort study was conducted in Patillas, Puerto Rico; 10- to 18-year-olds (N = 345) were randomly selected from 13 public schools. At enrollment, 49.8% of the entire cohort had DENV immunoglobulin G (IgG) anti-DENV antibodies, and there were individuals with neutralizing antibodies specific to each of the four DENV. The mean age of participants with incident DENV infection was 13.4 years. The 1-year seroincidence rate was 5.6%, and 61.1% of infections were inapparent. Having IgG anti-DENV at enrollment was associated with seroincidence (risk ratio = 6.8). Acute febrile illnesses during the study period were captured by a fever diary and an enhanced and passive surveillance system in the municipios of Patillas and Guayama. In summary, at enrollment, nearly one-half of the participants had a prior DENV infection, with the highest incidence in the 10- to 11-year-olds, of which most were inapparent infections, and symptomatic infections were considered mild.
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: D Fermín
authors: DF
authors: Argüello
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Kay M
authors: KM
authors: Tomashek
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Luz
authors: L
authors: Quiñones
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Manuela
authors: M
authors: Beltran
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Luz
authors: L
authors: Acosta
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Luis M
authors: LM
authors: Santiago
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Brad J
authors: BJ
authors: Biggerstaff
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Enid J
authors: EJ
authors: Garcia-Rivera
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Wellington
authors: W
authors: Sun
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Laurence
authors: L
authors: Pollissard-Gadroy
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France.
authors: Christine
authors: C
authors: Luxemburger
authors: National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico; Office of the Director, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Food and Drug Administration, Silver Spring, Maryland; Sanofi Aventis, Paris, France; Sanofi Pasteur, Lyon, France enh4@cdc.gov.
authors: Elizabeth
authors: E
authors: Hunsperger
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D003715:Dengue / Q000097:blood / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D011647:Puerto Rico / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
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