title: Detection of miRNA as non-invasive biomarkers of colorectal cancer.
abstract: Colorectal Cancer (CRC) is one of the deadliest cancers-ranking as the fourth most common cause of cancer-related deaths in the world. It is such a deadly disease because it is largely asymptomatic until the latter stages-oftentimes when the cancer has metastasized. Thus, a huge emphasis of cancer treatment is placed on early detection. Currently, there is a lack of a noninvasive, reliable, and cost-effective screening method for CRC. In recent years, microRNA (miRNA) diagnostic markers have been suggested as a viable new screening method for CRC. miRNAs play an important role in carcinogenesis, and has been observed to be dysregulated in many cancers including CRC. This review examines the diagnostic potential of circulatory and fecal miRNA markers in relation to CRC, as well as current techniques to detect them.
authors: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. albertren@u.northwestern.edu.
authors: Albert
authors: A
authors: Ren
authors: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. yujuan_dong@yahoo.com.
authors: Yujuan
authors: Y
authors: Dong
authors: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. frankie_tsoiho@yahoo.com.hk.
authors: Ho
authors: H
authors: Tsoi
authors: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. junyu@cuhk.edu.hk.
authors: Jun
authors: J
authors: Yu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005243:Feces / Q000737:chemistry; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D035683:MicroRNAs
references: Methods. 2010 Apr;50(4):298-301
references: 20146939
references: Int J Cancer. 2015 Mar 1;136(5):E359-86
references: 25220842
references: Cancer Genomics Proteomics. 2012 Jul-Aug;9(4):179-92
references: 22798503
references: Clin Cancer Res. 2014 Jun 1;20(11):2994-3002
references: 24691020
references: Ann Surg. 2013 Sep;258(3):400-8
references: 24022433
references: BMC Genomics. 2014;15:395
references: 24885883
references: Nat Cell Biol. 2007 Jun;9(6):654-9
references: 17486113
references: Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
references: 12184808
references: Dig Dis Sci. 2012 Apr;57(4):897-904
references: 22198701
references: Br J Cancer. 2009 Aug 18;101(4):707-14
references: 19672269
references: Nat Methods. 2013 Oct;10(10):1003-5
references: 23995387
references: Clin Chem. 2011 Jun;57(6):833-40
references: 21487102
references: Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8
references: 21383194
references: PLoS One. 2014;9(4):e87451
references: 24709885
references: Methods. 2013 Jan;59(1):101-7
references: 22926236
references: Cancer Genomics Proteomics. 2013 May-Jun;10(3):93-113
references: 23741026
references: Anal Biochem. 2012 Dec 1;431(1):69-75
references: 22982505
references: Br J Cancer. 2011 Mar 15;104(6):893-8
references: 21364594
references: PLoS One. 2013;8(6):e64795
references: 23762257
references: PLoS One. 2012;7(7):e41561
references: 22859996
references: Int J Cancer. 2010 Jul 1;127(1):118-26
references: 19876917
references: Cancer Prev Res (Phila). 2012 Mar;5(3):492-7
references: 22158052
references: Clin Chem. 2004 Sep;50(9):1678-80
references: 15331507
references: Cancer Sci. 2011 Dec;102(12):2264-71
references: 21883694
references: Wiley Interdiscip Rev RNA. 2012 Sep-Oct;3(5):601-16
references: 22566380
references: Cancer Prev Res (Phila). 2010 Nov;3(11):1435-42
references: 20959518
references: Nucleic Acids Res. 2011 Sep 1;39(16):7223-33
references: 21609964
references: Cleve Clin J Med. 2011 Aug;78(8):515-20
references: 21807923
references: Gut. 2009 Oct;58(10):1375-81
references: 19201770
references: Cancer Genomics Proteomics. 2009 Sep-Oct;6(5):281-95
references: 19996134
references: Cell. 1990 Jun 1;61(5):759-67
references: 2188735
references: PLoS One. 2013;8(5):e62880
references: 23690963
references: J Cancer Res Clin Oncol. 2013 Feb;139(2):223-9
references: 23052693
references: Br J Haematol. 2008 May;141(5):672-5
references: 18318758
references: Cell. 2004 Jan 23;116(2):281-97
references: 14744438
references: BMC Cancer. 2012;12:505
references: 23121918
references: Gastroenterology. 2005 Aug;129(2):422-8
references: 16083699
references: Sci Rep. 2014;4:5026
references: 24848278
references: Mol Cancer. 2009;8:102
references: 19912656
references: Ann Surg. 2012 Sep;256(3):544-51
references: 22868372
references: Methods. 2010 Apr;50(4):244-9
references: 20109550
references: Oncogene. 2008 Apr 3;27(15):2128-36
references: 17968323
references: Gastroenterology. 2010 Jun;138(6):2127-39
references: 20420950
references: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3
references: 23267864
references: PLoS One. 2013;8(9):e75184
references: 24073250
references: Pathol Int. 2010 May;60(5):351-7
references: 20518884
references: J Clin Oncol. 2006 Nov 20;24(33):5313-27
references: 17060676
references: Br J Cancer. 2014 Oct 28;111(9):1765-71
references: 25233396
references: Gut. 2008 Aug;57(8):1166-76
references: 18628378
references: Br Med Bull. 2013;105:29-42
references: 23299409
references: Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
references: 18663219
references: Front Genet. 2012 Oct 19;3:180
references: 23091478
references: Curr Opin Lipidol. 2012 Apr;23(2):91-7
references: 22418571
references: Gut. 2012 May;61(5):739-45
references: 21930727
references: Nat Methods. 2010 Sep;7(9):687-92
references: 20805796