title: [Pathogenesis of alcoholic chronic hepatitis].
abstract: In 1983, Nei et al. reported that alcoholic chronic hepatitis (ACH)(chronic hepatitis induced tal area. Recently, the number of alcoholics patients diagnosed with ACH has been increased In this review, we discussed the characteristics of liver histopathology and blood chemistry of ACH patients. In ACH, pericellular fibrosis, ballooned hepatocytes and/or bridging fibrosis, and infiltration of mononuclear lymphocytes is decreased after 6 to 8 weeks of abstinence from results suggest that ACH could be one type of alcoholic liver disease. The precise mechanism by alcohol) as one type of alcoholic liver disease. Since then, it has been discussed whether alcohol abuse, suggesting that alcohol may play a role in the infiltration of mononuclear lym ACH is one type of alcoholic liver disease, because there could be infection of unknown hepatitis virus in alcoholics and it is not clear why mononuclear lymphocytes infiltrate into the porphocytes in portal region. After abstinence of alcohol, serum levels of AST, ALT, and γ-GTP in patients with ACH returned to normal as in other types of alcoholic liver disease such as alcoholic fatty liver, alcoholic fibrosis, alcoholic hepatitis and alcoholic liver cirrhosis. These results suggest that ACH could be one type of alcoholic liver disease. The precise mechanism of the infiltration of mononuclear lymphocytes into portal areas of ACH patients is not known. We propose that the reason for the infiltration of natural killer (T) cells into portal areas could be due to the influx of endotoxin into portal vein resulting from the increased permeability of gut induced by alcohol.
authors: Nobuhiko
authors: N
authors: Hayashi
authors: Takashi
authors: T
authors: Saito
authors: Masahiro
authors: M
authors: Kakuda
authors: Yasuhiro
authors: Y
authors: Matsue
authors: Takashiro
authors: T
authors: Minato
authors: Atsushi
authors: A
authors: Fukumura
authors: Kazuaki
authors: K
authors: Ozaki
authors: Mutsumi
authors: M
authors: Tsuchisima
authors: Mikihiro
authors: M
authors: Tsutsumi
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004731:Endotoxins / Q000378:metabolism; D006518:Hepatitis Viruses; D006519:Hepatitis, Alcoholic / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D011169:Portal Vein / Q000378:metabolism / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D004731:Endotoxins; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase