title: Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells.
abstract: High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavin, as a therapeutic agent for endometrial cancer. Our results revealed that Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis.
authors: Department of Gynecologic Oncology, ShanDong Cancer Hospital & Cancer Institute, Jinan, 250117, P.R China. xiaoyun_han@med.unc.edu.|Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. xiaoyun_han@med.unc.edu.
authors: Xiaoyun
authors: X
authors: Han
authors: Department of Gynecologic Oncology, ShanDong Cancer Hospital & Cancer Institute, Jinan, 250117, P.R China. shengxiugui@163.com.
authors: Xiugui
authors: X
authors: Sheng
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. hannah_jones@med.unc.edu.
authors: Hannah M
authors: HM
authors: Jones
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. amaja@email.unc.edu.
authors: Amanda L
authors: AL
authors: Jackson
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. jekilgor@email.unc.edu.
authors: Joshua
authors: J
authors: Kilgore
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. Jessica.Stine@unchealth.unc.edu.
authors: Jessica E
authors: JE
authors: Stine
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. monica_schointuch@med.unc.edu.
authors: Monica N
authors: MN
authors: Schointuch
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. Chunxiao_zhou@med.unc.edu.|Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Chunxiao_zhou@med.unc.edu.
authors: Chunxiao
authors: C
authors: Zhou
authors: Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB# 7572, Physicians Office Building Rm# B105, Chapel Hill, NC, 27599, USA. victoria_baejump@med.unc.edu.|Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. victoria_baejump@med.unc.edu.
authors: Victoria L
authors: VL
authors: Bae-Jump
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D049934:Isocoumarins / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D049934:Isocoumarins; C572336:galloflavin; D007770:L-Lactate Dehydrogenase
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