title: Metformin action: concentrations matter.
abstract: Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.
authors: Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors: Ling
authors: L
authors: He
authors: Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: fwondis1@jhmi.edu.
authors: Fredric E
authors: FE
authors: Wondisford
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008687:Metformin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D008687:Metformin