title: Delayed onset of benign pleural effusion following concurrent chemoradiotherapy for inoperable non-small-cell lung cancer.
abstract: Chronic benign pleural effusion (BPE) is a rare complication of concurrent chemoradiotherapy (CRT) for inoperable stage IIIA non-small-cell lung cancer (NSCLC). This report presents three cases of BPE, the workup to differentiate this benign condition from recurrence of cancer and recommends a pleural biopsy as part of the diagnostic process. These inflammatory exudates often remain indolent, and may not require drainage or surgical intervention. In the absence of clinical, radiological and pathological evidence of recurrent disease, we recommend clinicians manage these patients expectantly, using regular clinical assessment and imaging.
authors: Department of Medical Oncology, Flinders Medical Centre, Adelaide, South Australia, Australia.
authors: R
authors: R
authors: Kumar
authors: G
authors: G
authors: Patel
authors: G
authors: G
authors: Kichenadasse
authors: S
authors: S
authors: Sukumaran
authors: A
authors: A
authors: Roy
authors: B
authors: B
authors: Koczwara
authors: J J
authors: JJ
authors: Bowden
authors: J
authors: J
authors: Leung
authors: T
authors: T
authors: Woo
authors: C S
authors: CS
authors: Karapetis
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects* / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*; D011859:Radiography; D018570:Risk Assessment; D012494:Sampling Studies; D019452:Terminally Ill; D013997:Time Factors; D016896:Treatment Outcome
keywords: benign pleural effusion; case series; concurrent chemoradiotherapy; non-small-cell lung cancer; stage III inoperable