title: Synthesis and determination of some biological activities of novel 2,4-dinitrophenyl derivatives.
abstract: The antioxidant and radical scavenging activities of the synthesized compounds 3, 5, and 6 were determined by various in vitro assays such as 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radical (ABTS(·+) ) scavenging, ferric ion (Fe(3+) ) reducing power and ferrous ion (Fe(2+) ) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds (3, 5, and 6) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1-6 showed Ki values in the range of 4.88-193.4 µM and 5.295-54.75 µM for hCA I and hCA II, respectively.
authors: Engineering and Natural Sciences Faculty, Food Engineering Department, Gumushane University, Gumushane, Turkey.
authors: Sevim B
authors: SB
authors: Öztürk Sarikaya
authors: Afşin A
authors: AA
authors: Kaya
authors: Elif Çelenk
authors: EÇ
authors: Kaya
authors: Murat
authors: M
authors: Şentürk
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004136:Dinitrobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D002257:Carbonic Anhydrase Inhibitors; D004136:Dinitrobenzenes; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: Antioxidant activity; Carbonic anhydrase; Enzyme inhibitor; Nitrobenzene