title: Two-dimensional micro-displacement measurement for laser coagulation using optical coherence tomography.
abstract: To improve the reproducibility of photocoagulation, the ability to quantitatively monitor the thermal change of laser-irradiated retinal tissue is required. Recently, optical coherence tomography has enabled non-invasive and non-contact monitoring of the tissue structural changes during laser irradiation. To further improve the capability of this technique, a method is proposed to measure tissue displacement by simultaneously using Doppler phase shifts and correlation coefficients. The theoretical approach for this method is described, and its performance is experimentally confirmed and evaluated. Finally, lateral and axial displacements in the laser-irradiated retinal tissues of an enucleated porcine eye are observed. The proposed method is found to be useful for further understanding the direct thermal response of laser-irradiated retinal tissue.
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Japan.
authors: Kazuhiro
authors: K
authors: Kurokawa
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Japan.
authors: Shuichi
authors: S
authors: Makita
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Japan.
authors: Young-Joo
authors: YJ
authors: Hong
authors: Computational Optics Group, University of Tsukuba, Tsukuba, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Japan.
authors: Yoshiaki
authors: Y
authors: Yasuno
keywords: (120.6150) Speckle imaging; (170.3340) Laser Doppler velocimetry; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography; (170.5755) Retina scanning
references: J Biomed Opt. 1999 Jan;4(1):95-105
references: 23015175
references: Opt Express. 2011 Mar 28;19(7):6623-34
references: 21451690
references: Biomed Opt Express. 2012 May 1;3(5):1025-46
references: 22567594
references: J Biomed Opt. 2012 Jun;17(6):061223
references: 22734753
references: Invest Ophthalmol Vis Sci. 2012 Jun 14;53(7):3605-14
references: 22562514
references: Opt Express. 2010 Jan 18;18(2):1358-72
references: 20173963
references: Opt Lett. 2006 Jan 15;31(2):190-2
references: 16441026
references: J Biomed Opt. 2013 Dec;18(12):121515
references: 24346855
references: Opt Express. 2006 Nov 27;14(24):11585-97
references: 19529578
references: Opt Express. 2012 Sep 24;20(20):22796-812
references: 23037430
references: Opt Express. 2009 May 11;17(10):8125-36
references: 19434144
references: Arch Ophthalmol. 1986 Jan;104(1):34-41
references: 2417579
references: Science. 1991 Nov 22;254(5035):1178-81
references: 1957169
references: Arch Ophthalmol. 1997 Apr;115(4):486-91
references: 9109757
references: J Biomed Opt. 2004 Jan-Feb;9(1):173-9
references: 14715070
references: Opt Express. 2014 Feb 24;22(4):4830-48
references: 24663800
references: Arch Ophthalmol. 1985 Dec;103(12):1796-806
references: 2866759
references: Opt Express. 1998 Sep 14;3(6):199-211
references: 19384362
references: J Biomed Opt. 2007 Mar-Apr;12(2):020501
references: 17477700
references: Ophthalmology. 1991 May;98(5 Suppl):766-85
references: 2062512