title: Motivation and affective judgments differentially recruit neurons in the primate dorsolateral prefrontal and anterior cingulate cortex.
abstract: The judgment of whether to accept or to reject an offer is determined by positive and negative affect related to the offer, but affect also induces motivational responses. Rewarding and aversive cues influence the firing rates of many neurons in primate prefrontal and cingulate neocortical regions, but it still is unclear whether neurons in these regions are related to affective judgment or to motivation. To address this issue, we recorded simultaneously the neuronal spike activities of single units in the dorsolateral prefrontal cortex (dlPFC) and the anterior cingulate cortex (ACC) of macaque monkeys as they performed approach-avoidance (Ap-Av) and approach-approach (Ap-Ap) decision-making tasks that can behaviorally dissociate affective judgment and motivation. Notably, neurons having activity correlated with motivational condition could be distinguished from neurons having activity related to affective judgment, especially in the Ap-Av task. Although many neurons in both regions exhibited similar, selective patterns of task-related activity, we found a larger proportion of neurons activated in low motivational conditions in the dlPFC than in the ACC, and the onset of this activity was significantly earlier in the dlPFC than in the ACC. Furthermore, the temporal onsets of affective judgment represented by neuronal activities were significantly slower in the low motivational conditions than in the other conditions. These findings suggest that motivation and affective judgment both recruit dlPFC and ACC neurons but with differential degrees of involvement and timing.
authors: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors: Ken-ichi
authors: http://orcid.org/0000-0001-8500-6820
authors: K
authors: Amemori
authors: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors: Satoko
authors: S
authors: Amemori
authors: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 graybiel@mit.edu.
authors: Ann M
authors: AM
authors: Graybiel
mesh_terms: D000818:Animals; D003657:Decision Making; D005260:Female; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D008253:Macaca mulatta; D009042:Motivation; D009474:Neurons / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*
keywords: anterior cingulate cortex; decision making; macaque; prefrontal cortex; primate
references: Nature. 2006 May 11;441(7090):223-6
references: 16633341
references: Cereb Cortex. 2015 Aug;25(8):2213-28
references: 24591526
references: J Neurosci. 2006 Jun 14;26(24):6469-72
references: 16775134
references: Nat Neurosci. 2006 Jul;9(7):940-7
references: 16783368
references: Neuron. 2006 Sep 21;51(6):861-70
references: 16982429
references: Nat Rev Neurosci. 2007 Apr;8(4):300-11
references: 17375042
references: J Neurosci. 2007 Aug 1;27(31):8170-3
references: 17670961
references: J Neurosci. 2007 Aug 1;27(31):8366-77
references: 17670983
references: Annu Rev Neurosci. 2001;24:167-202
references: 11283309
references: J Neurophysiol. 2001 Jun;85(6):2477-89
references: 11387394
references: Exp Brain Res. 2001 Oct;140(4):511-8
references: 11685405
references: J Neurophysiol. 2002 Mar;87(3):1488-98
references: 11877521
references: Science. 2002 May 31;296(5573):1709-11
references: 12040201
references: Psychon Bull Rev. 2003 Mar;10(1):167-76
references: 12747504
references: Science. 2003 Jul 11;301(5630):229-32
references: 12855813
references: Emotion. 2001 Sep;1(3):276-98
references: 12934687
references: Science. 2003 Nov 14;302(5648):1181-5
references: 14615530
references: Nat Neurosci. 2004 Apr;7(4):404-10
references: 15004564
references: Science. 2004 Apr 9;304(5668):307-10
references: 15073380
references: Neuron. 2004 Aug 5;43(3):415-25
references: 15294148
references: Science. 2004 Oct 15;306(5695):503-7
references: 15486304
references: Exp Brain Res. 1970 Nov 26;11(4):376-86
references: 4993199
references: Psychopharmacologia. 1971;21(1):1-7
references: 5105868
references: Brain Res. 1989 Aug 21;495(1):100-7
references: 2776028
references: Psychol Rev. 1990 Jul;97(3):377-95
references: 2200076
references: Nature. 1996 Mar 7;380(6569):69-72
references: 8598908
references: Nature. 1996 Aug 15;382(6592):629-32
references: 8757133
references: J Neurosci. 1997 Dec 1;17(23):9285-97
references: 9364074
references: Neuroreport. 1998 Aug 3;9(11):2663-7
references: 9721952
references: Biol Psychiatry. 1998 Dec 15;44(12):1248-63
references: 9861468
references: Rev Neurosci. 1998;9(4):225-41
references: 9886139
references: J Neurophysiol. 2005 Jun;93(6):3687-92
references: 15634707
references: Neurosci Res. 2007 Dec;59(4):431-45
references: 17905458
references: Psychophysiology. 2008 Jul;45(4):602-7
references: 18282202
references: Psychophysiology. 2008 Jul;45(4):516-23
references: 18513365
references: J Neurophysiol. 2008 Sep;100(3):1332-42
references: 18596188
references: J Neurosci. 2009 Mar 11;29(10):3259-70
references: 19279263
references: Psychophysiology. 2009 Jul;46(4):731-8
references: 19386053
references: J Neurosci. 2009 Nov 18;29(46):14617-26
references: 19923294
references: Psychol Sci. 2009 Dec;20(12):1500-6
references: 19906125
references: Nat Neurosci. 2010 May;13(5):538-9
references: 20348919
references: Biol Psychol. 2010 Jul;84(3):437-50
references: 19879918
references: Neuron. 2011 Jun 23;70(6):1054-69
references: 21689594
references: Annu Rev Neurosci. 2011;34:333-59
references: 21456961
references: J Neurosci. 2011 Aug 3;31(31):11110-7
references: 21813672
references: Nat Neurosci. 2011 Dec;14(12):1581-9
references: 22037498
references: PLoS Biol. 2011 Dec;9(12):e1001224
references: 22215982
references: J Neurosci. 2012 Mar 14;32(11):3791-808
references: 22423100
references: J Neurophysiol. 2012 Apr;107(7):1979-95
references: 22170970
references: Nat Neurosci. 2012 May;15(5):776-85
references: 22484571
references: J Neurosci. 2013 Oct 30;33(44):17385-97
references: 24174671
references: Cereb Cortex. 2006 Jul;16(7):1002-15
references: 16221932