title: The effects of short-term and long-term learning on the responses of lateral intraparietal neurons to visually presented objects.
abstract: The lateral intraparietal area (LIP) is thought to play an important role in the guidance of where to look and pay attention. LIP can also respond selectively to differently shaped objects. We sought to understand to what extent short-term and long-term experience with visual orienting determines the responses of LIP to objects of different shapes. We taught monkeys to arbitrarily associate centrally presented objects of various shapes with orienting either toward or away from a preferred spatial location of a neuron. The training could last for less than a single day or for several months. We found that neural responses to objects are affected by such experience, but that the length of the learning period determines how this neural plasticity manifests. Short-term learning affects neural responses to objects, but these effects are only seen relatively late after visual onset; at this time, the responses to newly learned objects resemble those of familiar objects that share their meaning or arbitrary association. Long-term learning affects the earliest bottom-up responses to visual objects. These responses tend to be greater for objects that have been associated with looking toward, rather than away from, LIP neurons' preferred spatial locations. Responses to objects can nonetheless be distinct, although they have been similarly acted on in the past and will lead to the same orienting behavior in the future. Our results therefore indicate that a complete experience-driven override of LIP object responses may be difficult or impossible. We relate these results to behavioral work on visual attention.
authors: 1University of Iceland.|2Brown University.
authors: Heida M
authors: HM
authors: Sigurdardottir
authors: 2Brown University.
authors: David L
authors: DL
authors: Sheinberg
mesh_terms: D000200:Action Potentials; D000818:Animals; D007858:Learning / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology; D012438:Saccades / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*
references: J Neurosci. 2008 Jun 25;28(26):6679-90
references: 18579742
references: Cognition. 2008 Aug;108(2):590-9
references: 18514179
references: J Cogn Neurosci. 2008 Aug;20(8):1423-33
references: 18303979
references: J Neurosci. 2009 Apr 29;29(17):5671-80
references: 19403833
references: Vision Res. 2009 Jun;49(10):1216-26
references: 18502468
references: Cereb Cortex. 2010 Jan;20(1):214-28
references: 19465740
references: Atten Percept Psychophys. 2010 Apr;72(3):597-601
references: 20348565
references: Annu Rev Neurosci. 2010;33:1-21
references: 20192813
references: Annu Rev Neurosci. 2010;33:269-98
references: 20345247
references: Annu Rev Neurosci. 2010;33:203-19
references: 20572771
references: Trends Neurosci. 2000 Jun;23(6):271-6
references: 10838597
references: Nat Neurosci. 2000 Jul;3(7):729-36
references: 10862707
references: J Neurophysiol. 2000 Jul;84(1):451-9
references: 10899218
references: Exp Brain Res. 2000 Jul;133(1):103-13
references: 10933215
references: Exp Brain Res. 2000 Jul;133(1):114-29
references: 10933216
references: Neuron. 2000 Jul;27(1):179-89
references: 10939341
references: Vision Res. 2000;40(20):2797-811
references: 10960652
references: J Comp Neurol. 2000 Dec 4;428(1):112-37
references: 11058227
references: Cereb Cortex. 2001 May;11(5):384-99
references: 11313291
references: Nature. 2002 Jan 10;415(6868):165-8
references: 11805833
references: J Neurophysiol. 2002 Feb;87(2):845-58
references: 11826051
references: Neuron. 2002 Feb 14;33(4):635-52
references: 11856536
references: Annu Rev Neurosci. 2002;25:189-220
references: 12052908
references: Psychon Bull Rev. 2002 Jun;9(2):314-8
references: 12120794
references: J Neurosci. 1984 Aug;4(8):2051-62
references: 6470767
references: J Neurosci. 1987 Feb;7(2):330-42
references: 3819816
references: J Neurophysiol. 1987 Mar;57(3):835-68
references: 3559704
references: J Exp Psychol Hum Percept Perform. 1989 May;15(2):315-30
references: 2525601
references: Vision Res. 1989;29(11):1631-47
references: 2635486
references: J Comp Neurol. 1990 Sep 22;299(4):421-45
references: 2243159
references: J Opt Soc Am A. 1991 Feb;8(2):440-9
references: 2007919
references: Trends Neurosci. 1992 Jan;15(1):20-5
references: 1374953
references: Cereb Cortex. 1991 Jan-Feb;1(1):1-47
references: 1822724
references: J Exp Psychol Hum Percept Perform. 1992 Nov;18(4):1030-44
references: 1431742
references: J Exp Psychol Gen. 1994 Jun;123(2):161-77
references: 8014611
references: Cereb Cortex. 1994 Sep-Oct;4(5):470-83
references: 7530521
references: J Neurophysiol. 1995 Jan;73(1):218-26
references: 7714567
references: J Comp Neurol. 1995 Mar 6;353(2):291-305
references: 7745137
references: Annu Rev Neurosci. 1996;19:109-39
references: 8833438
references: Annu Rev Neurosci. 1996;19:577-621
references: 8833455
references: Nature. 1997 Mar 13;386(6621):167-70
references: 9062187
references: J Neurophysiol. 1997 Aug;78(2):977-91
references: 9307128
references: Exp Brain Res. 1997 Nov;117(2):292-310
references: 9419075
references: Nature. 1998 Jan 29;391(6666):481-4
references: 9461214
references: J Cogn Neurosci. 1998 Mar;10(2):167-77
references: 9555105
references: J Exp Psychol Hum Percept Perform. 1998 Jun;24(3):847-58
references: 9627420
references: J Neurophysiol. 1998 Jun;79(6):3272-8
references: 9636126
references: Cereb Cortex. 1998 Sep;8(6):510-23
references: 9758214
references: Nature. 1998 Oct 1;395(6701):500-3
references: 9774105
references: Annu Rev Neurosci. 1999;22:319-49
references: 10202542
references: Vision Res. 1999 Aug;39(17):2929-46
references: 10492819
references: J Neurophysiol. 2005 Aug;94(2):1587-96
references: 16061496
references: Neuron. 2005 Nov 23;48(4):535-8
references: 16301170
references: Curr Opin Neurobiol. 2005 Dec;15(6):638-44
references: 16271465
references: J Neurosci. 2006 Jan 4;26(1):117-25
references: 16399678
references: J Neurophysiol. 2006 Feb;95(2):1078-98
references: 16221750
references: Atten Percept Psychophys. 2010 Jul;72(5):1244-50
references: 20601705
references: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13485-90
references: 20628011
references: Nat Neurosci. 2011 Aug;14(8):1075-9
references: 21765425
references: Nat Neurosci. 2012 Feb;15(2):315-20
references: 22246435
references: Psychophysiology. 2008 Nov;45(6):1013-24
references: 18801016
references: PLoS One. 2008;3(12):e3928
references: 19079541
references: J Exp Psychol Hum Percept Perform. 2009 Feb;35(1):1-16
references: 19170466
references: Nat Neurosci. 2002 Dec;5(12):1332-8
references: 12426571
references: Science. 2003 Jan 3;299(5603):81-6
references: 12511644
references: Nat Neurosci. 2003 Jun;6(6):555-6
references: 12754517
references: Cognition. 2004 Nov;94(1):B1-10
references: 15302333
references: Q J Exp Psychol. 1980 Feb;32(1):3-25
references: 7367577
references: Vision Res. 2012 Feb 15;55:32-40
references: 22239962
references: Eur J Neurosci. 2012 Apr;35(7):1083-91
references: 22487038
references: J Exp Psychol Gen. 2014 Feb;143(1):434-54
references: 23565670
references: J Neurosci. 2003 Nov 19;23(33):10540-7
references: 14627638
references: Eur J Neurosci. 2004 Feb;19(3):721-40
references: 14984423
references: Nat Rev Neurosci. 2004 Apr;5(4):291-303
references: 15034554
references: Exp Psychol. 2004;51(2):91-7
references: 15114901
references: Neuron. 2004 Jun 24;42(6):1003-12
references: 15207244
references: Neural Comput. 2004 Aug;16(8):1661-87
references: 15228749
references: J Physiol Paris. 2003 Jul-Nov;97(4-6):567-79
references: 15242666
references: Percept Psychophys. 2006 Feb;68(2):310-8
references: 16773902
references: J Neurosci. 2006 Sep 6;26(36):9239-49
references: 16957080
references: Nature. 2006 Sep 7;443(7107):85-8
references: 16936716
references: Q J Exp Psychol (Hove). 2006 Nov;59(11):1921-30
references: 16987781
references: J Neurophysiol. 2007 Jan;97(1):307-19
references: 17021033
references: Neuron. 2007 Aug 2;55(3):493-505
references: 17678860
references: Philos Trans R Soc Lond B Biol Sci. 2007 Sep 29;362(1485):1585-99
references: 17428779
references: Nat Neurosci. 2008 Feb;11(2):224-31
references: 18193041
references: Cereb Cortex. 2008 Mar;18(3):477-99
references: 17548798
references: Science. 2008 May 30;320(5880):1217-20
references: 18511690