title: Plasma and tissue homoarginine concentrations in healthy and obese humans.
abstract: Increased cardiovascular risk associated with obesity cannot be fully explained by traditional risk markers. We therefore assessed plasma and interstitial concentrations of the novel cardiovascular risk biomarker homoarginine (hArg) in 18 individuals without signs of cardiovascular disease, including 4 morbidly obese subjects before and after bariatric surgery and subsequent weight reduction of 36 ± 7 kg. hArg concentrations were greater in skeletal muscle compared with adipose tissue. Plasma and tissue hArg concentrations did not correlate with BMI. Adipose tissue interstitial hArg concentrations were not affected by obesity, an oral glucose load, or dramatic weight loss. In conclusion, obesity seems not to have a major effect on hArg homeostasis, and hArg may not explain the added cardiovascular risk associated with obesity. Yet, given the small sample size of the study, the significance of hArg in obesity should be investigated in a larger population.
authors: Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany, may.marcus@mh-hannover.de.
authors: Marcus
authors: M
authors: May
authors: Arslan Arinc
authors: AA
authors: Kayacelebi
authors: Sandor
authors: S
authors: Batkai
authors: Jens
authors: J
authors: Jordan
authors: Dimitrios
authors: D
authors: Tsikas
authors: Stefan
authors: S
authors: Engeli
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D005260:Female; D006709:Homoarginine / Q000097:blood*; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000601:surgery; D012307:Risk Factors
chemical_list: D006709:Homoarginine