title: Mesoionic compounds with antifungal activity against Fusarium verticillioides.
abstract: BACKGROUND
  Fungi contaminate the food of humans and animals, are a risk to health, and can cause financial losses. In this work, the antifungal activities of 16 mesoionic compounds (MI 1-16) were evaluated against mycotoxigenic fungi, including Aspergillus spp., Fusarium verticillioides and Penicillium citrinum. Furthermore, the decreased ergosterol in the total lipid content of Fusarium verticillioides was investigated.
  
  
  RESULTS
  F. verticillioides was the most sensitive fungus to the mesoionic compounds. Among the evaluated compounds, MI-11 and MI-16 presented higher antifungal effects against F. verticillioides, with MIC values of 7.8 μg/ml, and MI-2 and MI-3 followed, with MICs of 15.6 μg/ml. The most active compounds were those with heterocyclic ring phenyl groups substituted by electron donor moieties (MI-11 and MI-16). Among some compounds with higher activity (MI-2, MI-11 and MI-16), decreased ergosterol content in the total lipid fraction of F. verticillioides was demonstrated. MI-2 reduced the ergosterol content approximately 40% and 80% at concentrations of 7.8 μg/ml and 15.6 μg/ml, respectively, and MI-11 and MI-16 decreased the content by 30% and 50%, respectively, when at a concentration of 7.8 μg/ml.
  
  
  CONCLUSIONS
  These findings indicate that mesoionic compounds have significant antifungal activity against F. verticillioides.
authors: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23890-000, Seropédica, RJ, Brazil. rojanedeoliveirapaiva@gmail.com.|Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, 21040-900, RJ, Brazil. rojanedeoliveirapaiva@gmail.com.
authors: Rojane de Oliveira
authors: Rde O
authors: Paiva
authors: Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, 21040-900, RJ, Brazil. lucimar@ioc.fiocruz.br.
authors: Lucimar Ferreira
authors: LF
authors: Kneipp
authors: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23890-000, Seropédica, RJ, Brazil. quimicamilla@gmail.com.
authors: Camilla Moretto
authors: CM
authors: dos Reis
authors: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23890-000, Seropédica, RJ, Brazil. echevarr@ufrrj.br.
authors: Aurea
authors: A
authors: Echevarria
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D004875:Ergosterol / Q000032:analysis; D005670:Fusarium / Q000737:chemistry / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000187:drug effects; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D011083:Polycyclic Compounds; D004875:Ergosterol
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