title: [Study of polymorphism G54D of MBL2 gene in gestational diabetes mellitus].
abstract: OBJECTIVE
  To assess the association of the G54D (rs1800450) polymorphism of the gene MBL2 in the gestational diabetes mellitus with the need for additional treatment and the occurrence of large newborns for the gestational age.
  
  
  METHODS
  One hundred and five patients recruited in Joinville--Brazil were evaluated between November 2010 and October 2012. Pregnant women were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism G54D were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes.
  
  
  RESULTS
  Thirty-five point two percent of the evaluated patients carried at least one mutated allele of G54D polymorphism. There were no significant differences in weight gain, parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of patients with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%).
  
  
  CONCLUSIONS
  Our data showed that the polymorphism G54D of the gene MBL2 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population.
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Rejane
authors: R
authors: Baggenstoss
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Silvia Vanderléia
authors: SV
authors: Petzhold
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Izabela K Michels
authors: IK
authors: Willemann
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Francisco Simões
authors: FS
authors: Pabis
authors: Laboratório Gimenes, Joinville, SC, Brazil.
authors: Paulo
authors: P
authors: Gimenes
authors: Instituto Catarinense de Endocrinologia e Diabetes, Joinville, SC, Brazil.
authors: Barbara Vicente de
authors: BV
authors: Souza
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Paulo Henrique Condeixa de
authors: PH
authors: França
authors: Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brazil.
authors: Jean Carl
authors: JC
authors: Silva
mesh_terms: D000328:Adult; D000483:Alleles; D001724:Birth Weight / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D005320:Fetal Macrosomia / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D037601:Mannose-Binding Lectin / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D015430:Weight Gain; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin