title: Colloidally stabilized magnetic carbon nanotubes providing MRI contrast in mouse liver tumors.
abstract: The use of medical imaging contrast agents may lead to improved patient prognosis by potentially enabling an earlier detection of diseases and therefore an earlier initiation of treatments. In this study, we fabricated superparamagnetic iron oxide (SPIO) nanoparticles within the inner cavity of multiwalled carbon nanotubes (MWCNTs) for the first time; thereby ensuring high mechanical stability of the nanoparticles. A simple, but effective, self-assembled coating with RAFT diblock copolymers ensured the SPIO-MWCNTs have a high dispersion stability under physiological conditions. In vivo acute tolerance testing in mice showed a high tolerance dose up to 100 mg kg(-1). Most importantly, after administration of the material a 55% increase in tumor to liver contrast ratio was observed with in vivo MRI measurements compared to the preinjection image enhancing the detection of the tumor.
authors: Carbon Research Laboratory, Liaoning Key Lab for Energy Materials and Chemical Engineering, State Key Lab of Fine Chemicals, Dalian University of Technology , Dalian 116000, China.
authors: Yue
authors: Y
authors: Liu
authors: Benjamin W
authors: BW
authors: Muir
authors: Lynne J
authors: LJ
authors: Waddington
authors: Tracey M
authors: TM
authors: Hinton
authors: Bradford A
authors: BA
authors: Moffat
authors: Xiaojuan
authors: X
authors: Hao
authors: Jieshan
authors: J
authors: Qiu
authors: Timothy C
authors: TC
authors: Hughes
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003102:Colloids; D003287:Contrast Media; D005260:Female; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008807:Mice, Inbred BALB C; D053761:Nanocomposites; D037742:Nanotubes, Carbon
chemical_list: D003102:Colloids; D003287:Contrast Media; D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon