title: [Association of T190C polymorphism of β3 adrenergic receptor gene with response to carvedilol in patients with chronic heart failure].
abstract: OBJECTIVE
  To assess the association of T190C polymorphism of β3 adrenergic receptor gene (β3-AR) with chronic heart failure (CHF), and to evaluate the effect of this polymorphism on clinical response to β-AR blockade among patients with CHF.
  
  
  METHODS
  Three hundred and thirty patients with stable CHF receiving basic therapy for heart failure were included. Before initiation and 5 months after the maximal tolerated dose of carvedilol was reached, all indices including heart rate (HR), blood pressure (BP), left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP) level, 6 min walk distance were measured and compared with the indices of those with a T190C genotype. Distribution of the T190C polymorphisms in the control group and CHF group was compared.
  
  
  RESULTS
  The frequencies of T190C genotypes of the β3-AR gene have fit with the Hardy-Weinberg equilibrium. No significant difference was found between the frequencies of T190C alleles and genotypes between the two groups (P > 0.05). Compared with CC-homozygotes, TT-homozygous patients showed substantially greater improvement in LVEF and BNP (all P < 0.01).
  
  
  CONCLUSIONS
  No difference has been detected in the prevalence of the three genotypes between healthy and CHF subjects. The T190C variation of the β3-AR gene was not associated with increased risk for CHF. CHF patients with a T allele have greater response to carvedilol than those carrying a C allele in ethnic Han Chinese.
authors: Department of Cardiology, Huzhou Central Hospital, Huzhou, Zhejiang 313000, P. R. China. Email: czf918@qq.com.
authors: Haifeng
authors: H
authors: Yu
authors: Fanping
authors: F
authors: Wei
authors: Guoquan
authors: G
authors: Qian
authors: Lifang
authors: L
authors: Li
authors: Chuan
authors: C
authors: Zhang
authors: Zhenfeng
authors: Z
authors: Cheng
mesh_terms: D000328:Adult; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011412:Propanolamines / Q000627:therapeutic use*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D016277:Ventricular Function, Left
chemical_list: D002227:Carbazoles; D011412:Propanolamines; D022702:Receptors, Adrenergic, beta-3; D000077261:Carvedilol