title: Xenografts Supplemented with Pamindronate placed in postextraction sockets to avoid crestal bone resorption. Experimental study in Fox hound dogs.
abstract: OBJECTIVE
  The aim of the study was to compare the effects of porcine xenografts (MP3(®)) with or without pamindronate for the healing of small and large defects of postextraction sockets.
  
  
  METHODS
  Six beagle dogs were used in the study; second premolars and first molars of the mandible were extracted, small defects (SD) and large defects (LD) were identified. Each defect was measured and randomly filled as follows: SC (small control defects filled with MP3(®) alone), ST (small test defects filled with MP3(®) modified with pamindronate), LC (large control defects filled with MP3(®) alone), LT (large test defects filled with MP3(®) modified with pamindronate). After 4 and 8 weeks, the animals were euthanized and the percentages of new bone formation (NB), residual graft (RG) and connective tissue (CT) were analysed by histology and histomorphometry of undecalcified samples.
  
  
  RESULTS
  After 4 weeks, NB formation was higher for ST compared to all groups and for LT compared to LC (P < 0.05); RG was significantly higher in both control groups compared to tests (P < 0.05); and CT was higher in large defects (LC and LT) compared to small defects. After 8 weeks, NB formation was higher for test groups (ST and LT) compared to controls (P < 0.05); RG was significantly higher in both control groups compared to tests (P < 0.05); and CT was higher in large defects (LC and LT) compared to small defects (P < 0.05).
  
  
  CONCLUSIONS
  Within the limitations of this experimental study, the findings suggest that porcine xenografts modified with pamindronate favours the new bone formation and increased the porcine xenograft substitution/replacement after 4 and 8 weeks of healing.
authors: General Dentistry, International University of Catalonia, Barcelona, Spain.
authors: Naroa
authors: N
authors: Lozano-Carrascal
authors: Department of Prosthodontics and Digital Technology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors: Rafael Arcesio
authors: http://orcid.org/0000-0003-1721-0509
authors: RA
authors: Delgado-Ruiz
authors: Implant Dentistry, International University of Catalonia, Barcelona, Spain.
authors: Jordi
authors: J
authors: Gargallo-Albiol
authors: Restorative Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors: José Eduardo
authors: JE
authors: Maté-Sánchez
authors: Implant Dentistry, International University of Catalonia, Barcelona, Spain.
authors: Federico
authors: F
authors: Hernandez Alfaro
authors: General & Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors: José Luis
authors: http://orcid.org/0000-0002-9860-5416
authors: JL
authors: Calvo-Guirado
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D001641:Bicuspid / Q000601:surgery; D018786:Bone Substitutes / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D004285:Dogs; D064593:Heterografts; D008297:Male; D008334:Mandible / Q000601:surgery; D008963:Molar / Q000601:surgery; D000077268:Pamidronate; D011897:Random Allocation; D013524:Surgical Flaps; D013552:Swine; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000601:surgery
chemical_list: D018786:Bone Substitutes; D004164:Diphosphonates; C586522:osteobiol; D000077268:Pamidronate
keywords: biomaterials; bisphosphonates; bone grafting; bone substitutes; pamindronate; socket