title: Signaling in muscle contraction.
abstract: Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth muscle. Although these are similar, there are striking differences in the pathways that can be attributed to the distinct functional roles of the different muscle types. Muscles contract in response to depolarization, activation of G-protein-coupled receptors and other stimuli. The actomyosin fibers responsible for contraction require an increase in the cytosolic levels of calcium, which signaling pathways induce by promoting influx from extracellular sources or release from intracellular stores. Rises in cytosolic calcium stimulate numerous downstream calcium-dependent signaling pathways, which can also regulate contraction. Alterations to the signaling pathways that initiate and sustain contraction and relaxation occur as a consequence of exercise and pathophysiological conditions.
authors: Department of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06520.
authors: Ivana Y
authors: IY
authors: Kuo
authors: Department of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06520 Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut 06520.
authors: Barbara E
authors: BE
authors: Ehrlich
mesh_terms: D020013:Calcium Signaling; D006332:Cardiomegaly / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism; D008305:Malignant Hyperthermia / Q000378:metabolism; D008954:Models, Biological; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D015398:Signal Transduction
references: Circ Res. 2002 Oct 18;91(8):e21-6
references: 12386154
references: Biochem J. 2002 Jul 1;365(Pt 1):79-87
references: 11931630
references: J Physiol. 2011 Feb 15;589(Pt 4):783-95
references: 21173074
references: Cell Cycle. 2003 May-Jun;2(3):220-3
references: 12734428
references: Cardiovasc Res. 2007 Jan 1;73(1):10-8
references: 17045979
references: Physiol Rev. 2011 Oct;91(4):1447-531
references: 22013216
references: Am J Physiol Cell Physiol. 2008 Sep;295(3):C779-90
references: 18596214
references: Biol Cell. 2004 Feb;96(1):55-68
references: 15093128
references: Cold Spring Harb Perspect Biol. 2012 Jul 01;4(7):a011171
references: 22751152
references: J Cardiovasc Pharmacol. 2010 Dec;56(6):598-603
references: 20531218
references: J Cardiol. 2011 Mar;57(2):131-40
references: 21296556
references: Circ Res. 1994 Sep;75(3):434-42
references: 8062417
references: Physiol Rev. 2008 Oct;88(4):1341-78
references: 18923184
references: Hum Mutat. 2006 Oct;27(10):977-89
references: 16917943
references: Cell Calcium. 2009 May;45(5):474-84
references: 19376574
references: J Biol Chem. 2010 Feb 19;285(8):5522-31
references: 20018858
references: Pflugers Arch. 2010 Jun;460(1):153-62
references: 20401754
references: Circ Res. 2003 Mar 7;92 (4):411-8
references: 12600888
references: Circulation. 1995 Aug 15;92(4):778-84
references: 7641356
references: Science. 2010 Mar 26;327(5973):1653-7
references: 20185685
references: Arch Biochem Biophys. 2011 Jun 15;510(2):160-73
references: 21392499
references: Science. 1991 Apr 19;252(5004):443-6
references: 2017683
references: J Physiol. 2009 Jul 1;587(Pt 13):3125-33
references: 19403607
references: Nature. 2002 Aug 15;418(6899):797-801
references: 12181572
references: Cell. 1999 Sep 3;98(5):555-8
references: 10490095
references: Pharmacol Res. 2010 Nov;62(5):365-83
references: 20643208
references: Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H246-59
references: 17337597
references: Circ Res. 2007 Jan 5;100(1):10-2
references: 17204659
references: J Physiol. 2009 Aug 1;587(Pt 15):3899-910
references: 19505981
references: Endocr Rev. 2006 Dec;27(7):728-35
references: 17018837
references: Drug Discov Today Dis Mech. 2010 Summer;7(2):e151-e157
references: 21113427
references: Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8121-6
references: 9223325
references: Cold Spring Harb Perspect Biol. 2012 Nov 01;4(11):null
references: 23125017
references: Cold Spring Harb Perspect Biol. 2012 May 01;4(5):null
references: 22550228
references: Circ Res. 2000 Mar 3;86(4):386-90
references: 10700442
references: Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a011189
references: 22952397
references: Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996
references: 20961976
references: Annu Rev Physiol. 2010;72:81-94
references: 20148668
references: Nature. 1997 Oct 30;389(6654):990-4
references: 9353125
references: FEBS Lett. 2001 Mar 30;493(2-3):91-4
references: 11287002
references: Nature. 1996 Feb 1;379(6564):455-8
references: 8559251
references: FEBS J. 2005 Nov;272(22):5771-85
references: 16279942
references: Science. 1993 Oct 29;262(5134):740-4
references: 8235594
references: J Biol Chem. 1983 Jan 25;258(2):1197-204
references: 6337133
references: Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20405-10
references: 19918075
references: Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G830-7
references: 16763289
references: J Muscle Res Cell Motil. 2005;26(1):13-21
references: 16096682
references: Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
references: 21890489
references: J Clin Invest. 2006 Jun;116(6):1668-74
references: 16691292
references: Channels (Austin). 2010 Jan-Feb;4(1):67-71
references: 19934645
references: FASEB J. 2009 Jun;23(6):1710-20
references: 19237502
references: Nat Med. 2001 Nov;7(11):1236-40
references: 11689889
references: Proc Biol Sci. 2011 Sep 22;278(1719):2714-23
references: 21697171
references: Nature. 1991 Jun 27;351(6329):751-4
references: 1648178
references: Am J Physiol Cell Physiol. 2009 Nov;297(5):C1103-12
references: 19675303
references: Gastroenterology. 2008 Aug;135(2):610-20
references: 18586037
references: Hypertens Res. 2004 Apr;27(4):263-70
references: 15127884
references: Basic Clin Pharmacol Toxicol. 2012 Jan;110(1):42-8
references: 21999706
references: J Biol Chem. 1999 Dec 24;274(52):37385-90
references: 10601309
references: J Biol Chem. 1999 Jul 23;274(30):21085-94
references: 10409661