title: Transcription factors and cognate signalling cascades in the regulation of autophagy.
abstract: Autophagy is a process that maintains the equilibrium between biosynthesis and the recycling of cellular constituents; it is critical for avoiding the pathophysiology that results from imbalance in cellular homeostasis. Recent reports indicate the need for the design of high-throughput screening assays to identify targets and small molecules for autophagy modulation. For such screening, however, a better understanding of the regulation of autophagy is essential. In addition to regulation by various signalling cascades, regulation of gene expression by transcription factors is also critical. This review focuses on the various transcription factors as well as the corresponding signalling molecules that act together to translate the stimuli to effector molecules that up- or downregulate autophagy. This review rationalizes the importance of these transcription factors functioning in tandem with cognate signalling molecules and their interfaces as possible therapeutic targets for more specific pharmacological interventions.
authors: CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
authors: Vemika
authors: V
authors: Chandra
authors: CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
authors: Ella
authors: E
authors: Bhagyaraj
authors: CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
authors: Raman
authors: R
authors: Parkesh
authors: CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, India.
authors: Pawan
authors: P
authors: Gupta
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors
keywords: autophagy; gene regulation; nuclear receptors; signalling molecules; transcription factors