title: Dendritic cells and innate immunity in kidney transplantation.
abstract: This review summarizes emerging concepts related to the roles of dendritic cells (DCs) and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, DCs have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting DCs. Both concepts provide opportunities for preventing rejection by targeting monocytes or DCs.
authors: 1] Thomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA [2] Department of Transplantation, The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors: Quan
authors: Q
authors: Zhuang
authors: Thomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors: Fadi G
authors: FG
authors: Lakkis
mesh_terms: D064591:Allografts / Q000276:immunology*; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D016030:Kidney Transplantation; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
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