title: Biofilm as a virulence marker in Candida species in Nosocomial blood stream infection and its correlation with antifungal resistance.
abstract: Nosocomial blood stream infections (BSI) due to fungi especially Candida is increasing steadily. A two year prospective study was conducted in the S.C.B. Medical College with an aim to evaluate the species distribution, antifungal susceptibility and biofilm formation of Candida spp. isolated from nosocomial BSIs. 34 Candida spp. were isolated from 359 blood cultures. Antifungal susceptibility was performed by microbroth dilution technique and both visual and spectrophotometric method were used for biofilm detection. C. tropicalis was the common spp. isolated followed by C. parapsilosis and others. Most (92%) of the isolates were susceptible to Amphoterecin-B and highest resistance was observed against Flucytosine (37%) and Fluconazole(35%). Biofilm production and antifungal resistance was observed more in nonalbicans Candida spp.
authors: Department of Microbiology, Shri Ramachandra Bhanj Medical College and Hospital, Cuttack, India.
authors: M
authors: M
authors: Bhatt
authors: G
authors: G
authors: Sarangi
authors: B P
authors: BP
authors: Paty
authors: D
authors: D
authors: Mohapatra
authors: N
authors: N
authors: Chayani
authors: A
authors: A
authors: Mahapatra
authors: P
authors: P
authors: Das
authors: D
authors: D
authors: Sahoo
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000502:physiology*; D058387:Candidemia; D002177:Candidiasis / Q000175:diagnosis / Q000382:microbiology*; D003428:Cross Infection; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies; D014774:Virulence
chemical_list: D000935:Antifungal Agents