title: Differential effects of leptin and adiponectin in endothelial angiogenesis.
abstract: Obesity is a major health burden with an increased risk of cardiovascular morbidity and mortality. Endothelial dysfunction is pivotal to the development of cardiovascular disease (CVD). In relation to this, adipose tissue secreted factors termed "adipokines" have been reported to modulate endothelial dysfunction. In this review, we focus on two of the most abundant circulating adipokines, that is, leptin and adiponectin, in the development of endothelial dysfunction. Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis). Adiponectin, circulating at a much higher concentration, exists in different molecular weight forms, essentially made up of the collagenous fraction and a globular domain, the latter being investigated minimally for its involvement in proinflammatory processes including activation of NF-κβ and endothelial adhesion molecules. The opposing actions of the two forms of adiponectin in endothelial cells have been recently demonstrated. Additionally, a local and systemic change to multimeric forms of adiponectin has gained importance. Thus detailed investigations on the potential interplay between these adipokines would likely result in better understanding of the missing links connecting CVD, adipokines, and obesity.
authors: Division of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
authors: Raghu
authors: R
authors: Adya
authors: Division of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK ; Department of Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
authors: Bee K
authors: BK
authors: Tan
authors: Division of Translational and Systems Medicine-Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
authors: Harpal S
authors: HS
authors: Randeva
mesh_terms: D054392:Adipokines / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D007511:Ischemia; D020738:Leptin / Q000097:blood*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D009569:Nitric Oxide / Q000737:chemistry; D009765:Obesity / Q000503:physiopathology
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D016328:NF-kappa B; D009569:Nitric Oxide
references: Diabetes. 2005 Jul;54(7):2227-34
references: 15983226
references: Cardiovasc Res. 2012 Jan 1;93(1):170-80
references: 22065732
references: Endocrinology. 2002 Sep;143(9):3555-60
references: 12193570
references: Biochem Biophys Res Commun. 2011 Jan 28;404(4):1060-4
references: 21195057
references: Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2476-81
references: 14983034
references: Curr Diab Rep. 2003 Aug;3(4):293-8
references: 12866991
references: J Biol Chem. 2001 Jul 6;276(27):25096-100
references: 11342529
references: Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2156-63
references: 20814014
references: J Vasc Res. 2012;49(6):534-43
references: 22964477
references: FASEB J. 1999 Jul;13(10):1231-8
references: 10385613
references: J Mol Cell Cardiol. 2011 Jul;51(1):109-19
references: 21439968
references: Mol Aspects Med. 2005 Feb-Apr;26(1-2):33-65
references: 15722114
references: Clin Cancer Res. 2010 Feb 1;16(3):967-77
references: 20103676
references: Diabetologia. 2004 May;47(5):816-20
references: 15105989
references: J Clin Invest. 2007 Jun;117(6):1718-26
references: 17549259
references: Exp Mol Med. 2001 Jun 30;33(2):95-102
references: 11460888
references: J Cardiovasc Pharmacol. 2008 Feb;51(2):178-87
references: 18287886
references: Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):200-6
references: 19910644
references: Nature. 1994 Dec 1;372(6505):425-32
references: 7984236
references: Diabetologia. 2005 Jan;48(1):123-31
references: 15624093
references: Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10308-13
references: 15210937
references: Kidney Int. 1999 Sep;56(3):860-72
references: 10469355
references: Eur J Cardiovasc Prev Rehabil. 2004 Feb;11(1):33-40
references: 15167204
references: J Neurochem. 2010 Dec;115(5):1288-98
references: 20977476
references: Genes Nutr. 2008 Dec;3(3-4):177-80
references: 19034555
references: J Biochem. 1996 Oct;120(4):803-12
references: 8947845
references: Proc Natl Acad Sci U S A. 2001 May 22;98(11):6390-5
references: 11344271
references: Biochem Biophys Res Commun. 2004 Jan 30;314(1):151-8
references: 14715259
references: Hypertens Res. 2003 Feb;26(2):147-52
references: 12627874
references: Chin J Physiol. 2008 Feb 29;51(1):1-6
references: 18551989
references: Biochem J. 2006 Jan 1;393(Pt 1):7-20
references: 16336196
references: Endocr J. 2011;58(9):807-15
references: 21821964
references: Circ Res. 1998 Nov 16;83(10):1059-66
references: 9815153
references: Clin Chim Acta. 2005 Oct;360(1-2):9-26
references: 15982646
references: Ann Clin Biochem. 2011 Jul;48(Pt 4):327-31
references: 21502199
references: Front Immunol. 2012 Aug 07;3:240
references: 22891067
references: Biochem J. 2008 Feb 1;409(3):623-33
references: 18177270
references: J Biol Chem. 2003 Nov 7;278(45):45021-6
references: 12944390
references: Nephron. 2002;92(3):721-4
references: 12372966
references: Obesity (Silver Spring). 2012 Mar;20(3):498-504
references: 21996662
references: Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H605-12
references: 20581092
references: Atherosclerosis. 2003 Sep;170(1):21-9
references: 12957679
references: J Biol Chem. 2003 Dec 12;278(50):50810-7
references: 14522956
references: Cardiovasc Toxicol. 2002;2(3):165-80
references: 12665663
references: Science. 1998 Sep 11;281(5383):1683-6
references: 9733517
references: Mol Cell. 2005 Jan 21;17(2):171-80
references: 15664187
references: Circulation. 2006 Apr 18;113(15):1888-904
references: 16618833
references: Biochem Biophys Res Commun. 2004 Mar 5;315(2):264-71
references: 14766203
references: Gene Ther. 2013 Jan;20(1):93-101
references: 22357512
references: Cardiovasc Res. 2008 May 1;78(2):376-84
references: 18267956
references: J Endocrinol. 2004 Apr;181(1):1-10
references: 15072562
references: Diab Vasc Dis Res. 2008 Jun;5(2):123-7
references: 18537100
references: Eur Heart J. 2006 Oct;27(19):2294-9
references: 16543250
references: Circulation. 1997 Jun 3;95(11):2588-90
references: 9184592
references: J Am Coll Cardiol. 2004 Nov 2;44(9):1819-24
references: 15519013
references: Arterioscler Thromb Vasc Biol. 2008 May;28(5):899-905
references: 18292388
references: BMC Cancer. 2011;11:303
references: 21771332
references: Circulation. 2001 Dec 18;104(25):3052-6
references: 11748099
references: Metab Syndr Relat Disord. 2005 Summer;3(2):85-94
references: 18370715
references: Diabetologia. 2001 Apr;44(4):471-9
references: 11357478
references: Recent Prog Horm Res. 2004;59:225-44
references: 14749504
references: Biochem Biophys Res Commun. 2010 Jan 29;392(1):47-52
references: 20051227
references: J Intern Med. 1999 Oct;246(4):409-18
references: 10583712
references: J Clin Endocrinol Metab. 2001 May;86(5):1930-5
references: 11344187
references: Hypertension. 1997 Oct;30(4):934-41
references: 9336396
references: Diabetologia. 2005 Dec;48(12):2684-6
references: 16261311
references: Biochem Biophys Res Commun. 1996 Apr 16;221(2):286-9
references: 8619847
references: Circulation. 1999 Dec 21-28;100(25):2473-6
references: 10604883
references: Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1143-54
references: 21900123
references: J Intern Med. 2005 Feb;257(2):167-75
references: 15656875
references: Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):7-9
references: 14707035
references: Physiol Rev. 2004 Oct;84(4):1381-478
references: 15383655
references: Am J Physiol Endocrinol Metab. 2008 May;294(5):E978-86
references: 18349107
references: Horm Metab Res. 2004 Jul;36(7):453-7
references: 15305227
references: Diabetes Care. 2004 Oct;27(10):2488-90
references: 15451921
references: Nat Med. 2001 Aug;7(8):941-6
references: 11479627
references: FASEB J. 1998 Jan;12(1):57-65
references: 9438411
references: Diabetes. 2006 Jun;55(6):1840-6
references: 16731851
references: J Clin Endocrinol Metab. 2006 Jun;91(6):2310-6
references: 16551730
references: Coron Artery Dis. 1999 Jun;10(4):241-56
references: 10376203
references: Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1605-12
references: 22580898
references: Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E159-64
references: 17374693
references: J Biol Chem. 1995 Nov 10;270(45):26746-9
references: 7592907
references: Nature. 2003 Jun 12;423(6941):762-9
references: 12802337
references: Circulation. 2000 Sep 12;102(11):1296-301
references: 10982546
references: Diabetes. 2003 Aug;52(8):2121-8
references: 12882931
references: Atherosclerosis. 2001 Aug;157(2):495-503
references: 11472752
references: Clin Exp Immunol. 2003 Jul;133(1):11-9
references: 12823272
references: Circulation. 2001 Feb 27;103(8):1057-63
references: 11222466
references: Endocrine. 2011 Dec;40(3):386-93
references: 21948177
references: J Biol Chem. 1996 May 3;271(18):10697-703
references: 8631877
references: Nature. 1998 Oct 22;395(6704):763-70
references: 9796811
references: Thromb Haemost. 2010 May;103(5):1065-75
references: 20174754
references: J Biol Chem. 2004 Jan 9;279(2):1304-9
references: 14557259
references: Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2031-41
references: 15653761
references: Diabetes. 2000 Feb;49(2):293-7
references: 10868946
references: PLoS One. 2011;6(6):e21467
references: 21731759
references: J Clin Endocrinol Metab. 2004 Jun;89(6):2563-8
references: 15181024
references: PLoS One. 2011;6(4):e18823
references: 21533119
references: Diabetes Obes Metab. 2006 Nov;8(6):603-10
references: 17026484
references: Atherosclerosis. 2004 Jan;172(1):175-80
references: 14709373
references: Can J Cardiol. 2008 May;24(5):385-90
references: 18464944
references: Int J Cardiol. 2008 May 7;126(1):53-61
references: 17477992
references: J Mol Cell Cardiol. 2008 Feb;44(2):388-94
references: 18054040
references: Int J Obes Relat Metab Disord. 2002 Nov;26(11):1407-33
references: 12439643
references: FEBS Lett. 2008 May 28;582(12):1719-24
references: 18455514
references: Biochem Biophys Res Commun. 2003 Dec 26;312(4):1118-22
references: 14651988
references: Eur J Clin Invest. 2002 Jun;32 Suppl 3:14-23
references: 12028371
references: Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H48-56
references: 15749744
references: Diabetes. 2002 Jan;51(1):168-73
references: 11756337
references: Endocrinology. 2005 Feb;146(2):790-6
references: 15528304
references: Hypertension. 2003 Sep;42(3):231-4
references: 12860835
references: J Physiol. 2012 Sep 1;590(Pt 17):4255-68
references: 22674721
references: Obesity (Silver Spring). 2011 Jul;19(7):1492-6
references: 21183936
references: Nat Med. 2004 Jun;10(6):563-9
references: 15170194
references: Stroke. 2007 Oct;38(10):2844-6
references: 17823381
references: J Clin Endocrinol Metab. 2004 Feb;89(2):765-9
references: 14764794
references: Atherosclerosis. 2008 Jan;196(1):68-75
references: 17362969
references: J Biol Chem. 2004 Jul 2;279(27):28670-4
references: 15123726
references: Diabetes. 2007 Mar;56(3):804-8
references: 17327451
references: J Exp Clin Cancer Res. 2011;30:21
references: 21338489