title: Association between some inflammatory markers and primary ovarian insufficiency.
abstract: OBJECTIVE
  This study investigated the discriminative values of neutrophil-to-lymphocyte ratio (NLR), serum amyloid A protein (SAA), and C-reactive protein (CRP) in cases of primary ovarian insufficiency (POI).
  
  
  METHODS
  A total of 84 women were included in this comparative cross-sectional study. The study group consisted of 43 women diagnosed as having POI, and the control group consisted of 41 women with normal fertility. After obtaining a written informed consent form from all participants, we retrieved clinical and demographic data and laboratory findings from the participants and the hospital database. The following variables were analyzed: age, body mass index, smoking, family history, comorbidities, sonographic findings, complete blood count, baseline hormone levels, CRP, and SAA.
  
  
  RESULTS
  NLR was significantly lower in the study group than in the control group (mean [SD], 1.3 [0.7] vs 2.0 [0.7]; P < 0.001). The mean SAA level was 151.6 ng/mL (range, 48.5-12,554.7 ng/mL) in the study group and 147.8 ng/mL (range, 29.8-3,760.4 ng/mL) in the control group (P > 0.05). There was no significant difference in serum CRP levels between two groups (P > 0.05). Receiver operating characteristic analysis revealed that NLR, but not SAA and CRP, was a significantly discriminative parameter for POI (area under the curve, 0.829; P < 0.001). Multivariate logistic regression analysis showed that a family history of POI, smoking, and NLR of 1.5 or less were independent risk factors for POI.
  
  
  CONCLUSIONS
  SAA and CRP do not seem to be valuable discriminative markers for POI, whereas NLR may be a significant promising marker before presentation or in the early stages of POI and may be useful for developing appropriate fertility treatment options.
authors: 1Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey 2Department of Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors: Gülçin
authors: G
authors: Yldrm
authors: Aytekin
authors: A
authors: Tokmak
authors: Mahmut Kuntay
authors: MK
authors: Kokanal
authors: Esma
authors: E
authors: Sarkaya
authors: Cevdet
authors: C
authors: Züngün
authors: Hasan Ali
authors: HA
authors: İnal
authors: Fatma Meriç
authors: FM
authors: Ylmaz
authors: Nafiye
authors: N
authors: Ylmaz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female; D007249:Inflammation; D008214:Lymphocytes; D009504:Neutrophils; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000276:immunology*; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein