title: The association of central venous catheter placement timing with infection rates in patients with acute leukemia.
abstract: BACKGROUND
  Timing of central venous catheter (CVC) insertion among patients with acute leukemia is debatable. Early insertion increases convenience, but might increase infection rates.
  
  
  METHODS
  We assessed retrospectively the rate of central line-associated bloodstream infections (CLABSI) according to CVC time of insertion in patients with acute leukemia admitted for induction or salvage therapy. The study was conducted in the Hematology Department of a Tertiary hospital in Israel between 2007 and 2011. Early CVC placement was defined as CVC inserted during the first week of induction therapy. CLABSI rate was documented between the seventh day of induction therapy to 30 days after its completion.
  
  
  RESULTS
  A total of 127 patients were included. Acute myeloid leukemia was the most common diagnosis (103 patients, 80.5%). Late CVC placement was associated with CLABSI after adjustment to the Charlson comorbidity index (OR 3.4, 95% CI 1.1-10.45), p=0.03.
  
  
  CONCLUSIONS
  Delaying CVC placement in adult patients with acute leukemia may be associated with higher rate of CLABSI in the early period after induction therapy.
authors: Department of Medicine F-Recanati, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel. Electronic address: et.kugler@gmail.com.
authors: Eitan
authors: E
authors: Kugler
authors: Department of Medicine F-Recanati, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
authors: Amos
authors: A
authors: Levi
authors: Department of Medicine F-Recanati, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Elad
authors: E
authors: Goldberg
authors: Department of Medicine F-Recanati, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
authors: Eli
authors: E
authors: Zaig
authors: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel.
authors: Pia
authors: P
authors: Raanani
authors: Division of Infectious Diseases, Rambam Health Care Campus and The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors: Mical
authors: M
authors: Paul
mesh_terms: D000328:Adult; D000368:Aged; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction; D012189:Retrospective Studies; D016879:Salvage Therapy; D013997:Time Factors
keywords: CLABSI; Induction therapy; Infection rate