title: Laparoscopic portoenterostomy versus open portoenterostomy for the treatment of biliary atresia: a systematic review and meta-analysis of comparative studies.
abstract: BACKGROUND
  Open portoenterostomy (OPE) remains the mainstay in treatment of biliary atresia, while during the past several years, the laparoscopic portoenterostomy (LPE) has been widely introduced. However, safety of LPE remains a major concern. Thus, we conducted a systematic review and meta-analysis to review the currently available data comparing LPE and OPE.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  Medline, Ovid, Elsevier, Google Scholar Embase, Cohrane library.
  
  
  METHODS
  Comparative cohort studies.
  
  
  METHODS
  Two investigators independently assessed selected studies and extracted the following information: study characteristics, quality, outcomes data, etc.
  
  
  RESULTS
  Eleven studies about the effectiveness of LPE compared with OPE were performed by meta-analysis. Meta-analysis found no significant difference between the two groups in operative time, hospital stay, intraoperative blood loss, early clearance of jaundice, cholangitis and variceal bleeding. In addition, the rate of 2-year survival with native liver was significantly high in OPE group than in LPE group.
  
  
  CONCLUSIONS
  Laparoscopic portoenterostomy could not replace open portoenterostomy and open Kasai portoenterostomy remains the gold standard in the treatment of biliary atresia.
authors: Department of Pediatric Surgery, Capital Institute of Pediatrics, Teaching hospital of Peking University, Yabao Road2#, Chaoyang, Beijing, 100021, People's Republic of China.
authors: Ma
authors: M
authors: Lishuang
authors: Chen
authors: C
authors: Zhen
authors: Qiao
authors: Q
authors: Guoliang
authors: Zhang
authors: Z
authors: Zhen
authors: Wang
authors: W
authors: Chen
authors: Li
authors: L
authors: Long
authors: Liu
authors: L
authors: Shuli
mesh_terms: D001652:Bile Ducts / Q000601:surgery; D001656:Biliary Atresia / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D011171:Portoenterostomy, Hepatic / Q000379:methods*; D016896:Treatment Outcome
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