title: State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications.
abstract: Recently, an increasing number of publications have demonstrated the importance of the small molecule nitric oxide (NO) in several physiological and pathophysiological processes. NO acts as a key modulator in cardiovascular, immunological, neurological, and respiratory systems, and deficiencies in the production of NO or its inactivation has been associated with several pathologic conditions, ranging from hypertension to sexual dysfunction. Although the clinical administration of NO is still a challenge owing to its transient chemical nature, the combination of NO and nanocarriers based on biocompatible polymeric scaffolds has emerged as an efficient approach to overcome the difficulties associated with the biomedical administration of NO. Indeed, significant progress has been achieved by designing NO-releasing polymeric nanomaterials able to promote the spatiotemporal generation of physiologically relevant amounts of NO in diverse pharmacological applications. In this review, we summarize the recent advances in the preparation of versatile NO-releasing nanocarriers based on polymeric nanoparticles, dendrimers and micelles. Despite the significant innovative progress achieved using nanomaterials to tailor NO release, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. In this regard, this review discusses the state of the art regarding the preparation of innovative NO-releasing polymeric nanomaterials, their impact in the biological field and the challenges that need to be overcome. We hope to inspire new research in this exciting area based on NO and nanotechnology.
authors: Exact and Earth Sciences Department, Universidade Federal de São Paulo, São Nicolau 210, 09913-030 Diadema, SP, Brazil. Electronic address: amedea.seabra@unifesp.com.br.
authors: Amedea B
authors: AB
authors: Seabra
authors: Department of Biochemistry, Universidade Federal de São Paulo, 3 de Maio 100, 04044-020 São Paulo, SP, Brazil; Department of Biological Sciences, Universidade Federal de São Paulo, 3 de Maio 100, 04044-020 São Paulo, SP, Brazil.
authors: Giselle Z
authors: GZ
authors: Justo
authors: Exact and Earth Sciences Department, Universidade Federal de São Paulo, São Nicolau 210, 09913-030 Diadema, SP, Brazil.
authors: Paula S
authors: PS
authors: Haddad
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D050091:Dendrimers; D008823:Micelles; D020030:Nitric Oxide Donors; D011108:Polymers; D009569:Nitric Oxide
keywords: Antibacterial; Cancer; Dendrimers; Drug release; Micelles; NONOates; Nitric oxide; Polymeric nanoparticles; S-nitrosothiols