title: Characterization of the cation-binding capacity of a potassium-adsorption filter used in red blood cell transfusion.
abstract: A K(+) -adsorption filter was developed to exchange K(+) in the supernatant of stored irradiated red blood cells with Na(+) . To date, however, the filter's adsorption capacity for K(+) has not been fully evaluated. Therefore, we characterized the cation-binding capacity of this filter. Artificial solutions containing various cations were continuously passed through the filter in 30 mL of sodium polystyrene sulfonate at 10 mL/min using an infusion pump at room temperature. The cation concentrations were measured before and during filtration. When a single solution containing K(+) , Li(+) , H(+) , Mg(2+) , Ca(2+) , or Al(3+) was continuously passed through the filter, the filter adsorbed K(+) and the other cations in exchange for Na(+) in direct proportion to the valence number. The order of affinity for cation adsorption to the filter was Ca(2+) >Mg(2+) >K(+) >H(+) >Li(+) . In K(+) -saturated conditions, the filter also adsorbed Na(+) . After complete adsorption of these cations on the filter, their concentration in the effluent increased in a sigmoidal manner over time. Cations that were bound to the filter were released if a second cation was passed through the filter, despite the different affinities of the two cations. The ability of the filter to bind cations, especially K(+) , should be helpful when it is used for red blood cell transfusion at the bedside. The filter may also be useful to gain a better understanding of the pharmacological properties of sodium polystyrene sulfonate.
authors: Department of Clinical Engineering, Shimotsuke, Tochigi, Japan.
authors: Takao
authors: T
authors: Suzuki
authors: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Shigeaki
authors: S
authors: Muto
authors: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Yukio
authors: Y
authors: Miyata
authors: Department of Clinical Engineering, Shimotsuke, Tochigi, Japan.
authors: Takao
authors: T
authors: Maeda
authors: Department of Clinical Engineering, Shimotsuke, Tochigi, Japan.
authors: Takayuki
authors: T
authors: Odate
authors: Department of Clinical Engineering, Shimotsuke, Tochigi, Japan.
authors: Kimio
authors: K
authors: Shimanaka
authors: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
authors: Eiji
authors: E
authors: Kusano
mesh_terms: D000327:Adsorption; D002411:Cation Exchange Resins / Q000737:chemistry*; D002412:Cations / Q000378:metabolism; D017707:Erythrocyte Transfusion / Q000295:instrumentation / Q000379:methods*; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D011137:Polystyrenes / Q000737:chemistry*; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
chemical_list: D002411:Cation Exchange Resins; D002412:Cations; D011137:Polystyrenes; C003321:polystyrene sulfonic acid; D012964:Sodium; D011188:Potassium
keywords: Extracellular potassium; Resin filter; Sodium polystyrene sulfonate resin; Stored irradiated red blood cells