title: No relationship of lipid-lowering agents to hematoma growth: pooled analysis of the intensive blood pressure reduction in acute cerebral hemorrhage trials studies.
abstract: OBJECTIVE
  Controversy persists over statins and risk of intracerebral hemorrhage. We determined associations of premorbid lipid-lowering therapy and outcomes among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT).
  
  
  METHODS
  The pooled data of INTERACT 1 and 2 (international, multicenter, prospective, open, blinded end point, randomized controlled trials of patients with intracerebral hemorrhage [<6 hours] and elevated systolic blood pressure) were analyzed with regard to associations of baseline lipid-lowering treatment and clinical outcomes of 3184 participants in a multivariate model. Associations of lipid-lowering therapy and hematoma growth (baseline to 24 hours) in computed tomographic substudies participants (n=1310) were estimated in ANCOVA.
  
  
  RESULTS
  Among 204 patients (6.5%) with baseline lipid-lowering treatment, 90-day clinical outcomes were not significantly different after adjustment for confounding variables including region and age. In the computed tomographic substudy, 24-hour hematoma growth was greater in 124 patients (9%) with, compared with those without, prior lipid-lowering therapy. However, this association was not significant between groups (9.2 versus 6.8 mL; P<0.13), after adjustment for prior antithrombotic therapy.
  
  
  CONCLUSIONS
  No independent associations were found between lipid-lowering medication and adverse outcomes in patients with intracerebral hemorrhage.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.
authors: From the Department of Neurology, Stroke Network, Royal North Shore Hospital, Sydney, Australia (M.P., M.K.); Department of Neurology, George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, Australia (H.A., C.A.); and Sydney Medical School,University of Sydney, Sydney, Australia (M.K., H.A., C.A.). miriam.priglinger@health.nsw.gov.au.
authors: Miriam
authors: M
authors: Priglinger
authors: From the Department of Neurology, Stroke Network, Royal North Shore Hospital, Sydney, Australia (M.P., M.K.); Department of Neurology, George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, Australia (H.A., C.A.); and Sydney Medical School,University of Sydney, Sydney, Australia (M.K., H.A., C.A.).
authors: Hisatomi
authors: H
authors: Arima
authors: From the Department of Neurology, Stroke Network, Royal North Shore Hospital, Sydney, Australia (M.P., M.K.); Department of Neurology, George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, Australia (H.A., C.A.); and Sydney Medical School,University of Sydney, Sydney, Australia (M.K., H.A., C.A.).
authors: Craig
authors: C
authors: Anderson
authors: From the Department of Neurology, Stroke Network, Royal North Shore Hospital, Sydney, Australia (M.P., M.K.); Department of Neurology, George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, Australia (H.A., C.A.); and Sydney Medical School,University of Sydney, Sydney, Australia (M.K., H.A., C.A.).
authors: Martin
authors: M
authors: Krause
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D001921:Brain / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications; D007391:International Cooperation; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D013599:Systole; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids
keywords: cerebral hemorrhage; statins, HMG-CoA