title: Radiopharmaceuticals as probes to characterize tumour tissue.
abstract: Tumour cells exhibit several properties that allow them to grow and divide. A number of these properties are detectable by nuclear imaging methods. We discuss crucial tumour properties that can be described by current radioprobe technologies, further discuss areas of emerging radioprobe development, and finally articulate need areas that our field should aspire to develop. The review focuses largely on positron emission tomography and draws upon the seminal 'Hallmarks of Cancer' review article by Hanahan and Weinberg in 2011 placing into context the present and future roles of radiotracer imaging in characterizing tumours.
authors: Comprehensive Cancer Imaging Centre, Imperial College London, London, W12 0NN, UK.
authors: Israt S
authors: IS
authors: Alam
authors: Mubarik A
authors: MA
authors: Arshad
authors: Quang-Dé
authors: QD
authors: Nguyen
authors: Eric O
authors: EO
authors: Aboagye
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals
references: Radiother Oncol. 2012 Oct;105(1):29-35
references: 22677038
references: Br J Radiol. 2003 Aug;76(908):553-60
references: 12893698
references: J Nucl Med. 2007 Mar;48(3):420-8
references: 17332620
references: Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1766-74
references: 18465129
references: Nucl Med Biol. 2011 Jan;38(1):39-51
references: 21220128
references: Ann Nucl Med. 2012 Feb;26(2):138-45
references: 22069194
references: Clin Genitourin Cancer. 2014 Apr;12 (2):106-10
references: 24135632
references: J Nucl Med. 2003 Dec;44(12 ):1927-32
references: 14660718
references: Nucl Med Commun. 2002 Mar;23 (3):229-36
references: 11891480
references: J Comput Assist Tomogr. 2009 May-Jun;33(3):460-5
references: 19478644
references: J Nucl Med. 2013 Aug;54(8):1175-80
references: 23753185
references: Bioorg Med Chem. 2009 Feb 15;17(4):1486-93
references: 19188071
references: Trends Genet. 2013 Sep;29(9):513-20
references: 23876621
references: J Microsc. 2008 Sep;231(3):441-5
references: 18754999
references: Bioconjug Chem. 2010 May 19;21(5):884-91
references: 20402461
references: Cancer Metastasis Rev. 2007 Jun;26(2):225-39
references: 17440684
references: J Nucl Med. 2012 Feb;53(2):182-90
references: 22241912
references: AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1278-83
references: 23275592
references: Acta Radiol. 2014 May;55(4):389-98
references: 23928010
references: Cancer Res. 2001 Jan 1;61(1):110-7
references: 11196147
references: Eur J Nucl Med Mol Imaging. 2010 Aug;37(9):1663-8
references: 20369236
references: Jpn J Cancer Res. 1999 Apr;90(4):419-24
references: 10363580
references: Cell. 2013 Jan 31;152(3):390-3
references: 23374336
references: Eur J Nucl Med Mol Imaging. 2011 Dec;38(12):2186-97
references: 21892622
references: Genome Integr. 2013 Oct 24;4(1):5
references: 24152759
references: J Nucl Med. 2013 Jul;54(7):1106-12
references: 23699667
references: Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16375-80
references: 19805307
references: J Nucl Med. 1995 Jul;36(7):1301-6
references: 7790960
references: J Clin Invest. 2010 Jun;120(6):2005-15
references: 20484820
references: Nat Rev Cancer. 2011 Feb;11(2):85-95
references: 21258394
references: Nat Rev Cancer. 2012 Jan 12;12 (2):133-43
references: 22237392
references: Cell. 1996 Aug 9;86(3):353-64
references: 8756718
references: Science. 2005 Jan 7;307(5706):58-62
references: 15637262
references: Clin Cancer Res. 2012 Feb 15;18(4):1063-72
references: 22235095
references: J Nucl Med. 2013 Jul;54(7):1014-8
references: 23651946
references: Biomed Res Int. 2014;2014:103718
references: 24877053
references: J Nucl Med. 2013 Feb;54(2):192-200
references: 23321459
references: Eur J Nucl Med Mol Imaging. 2003 Jan;30(1):101-8
references: 12483416
references: Eur J Nucl Med Mol Imaging. 2009 Oct;36(10 ):1674-86
references: 19565239
references: Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1603-8
references: 21220318
references: J Nucl Med. 2010 Nov;51(11):1676-83
references: 20956477
references: J Clin Oncol. 2013 Jan 10;31(2):187-94
references: 23213092
references: Lancet Oncol. 2007 Oct;8(10):889-97
references: 17851129
references: J Nucl Med. 2007 Apr;48(4):508-18
references: 17401086
references: Eur J Nucl Med Mol Imaging. 2002 Sep;29(9):1174-81
references: 12192562
references: Eur J Nucl Med Mol Imaging. 2008 Mar;35(3):509-18
references: 17994297
references: Am J Nucl Med Mol Imaging. 2012;2(1):33-47
references: 23133801
references: J Urol. 2013 Apr;189(4):1308-13
references: 23123372
references: Pract Radiat Oncol. 2013 Apr-Jun;3(2 Suppl 1):S23
references: 24674522
references: Mol Imaging Biol. 2006 Jan-Feb;8(1):36-42
references: 16362149
references: J Gastroenterol. 1999 Aug;34(4):474-80
references: 10452680
references: Clin Cancer Res. 2008 Jan 1;14 (1):123-9
references: 18172261
references: Clin Cancer Res. 2014 Mar 15;20(6):1632-43
references: 24493830
references: J Clin Oncol. 2006 Jun 20;24(18):2793-9
references: 16682724
references: J Nucl Med. 2011 Jul;52(7):1048-55
references: 21680694
references: Nat Med. 2012 Oct;18(10 ):1586-91
references: 23001181
references: J Nucl Med. 2011 Apr;52(4):592-9
references: 21421722
references: Cell. 2000 Jan 7;100(1):57-70
references: 10647931
references: J Nucl Med. 2014 Mar;55(3):515-21
references: 24491409
references: Clin Nucl Med. 2012 Apr;37(4):e67-72
references: 22391726
references: Q J Nucl Med Mol Imaging. 2013 Jun;57(2):187-200
references: 23389693
references: Cancer Res. 2014 Mar 1;74(5):1319-28
references: 24590807
references: J Nucl Med. 2014 Jan;55(1):128-34
references: 24337603
references: J Nucl Med. 2011 Oct;52(10 ):1573-9
references: 21903741
references: Nature. 2013 Sep 19;501(7467):421-5
references: 23945590
references: Eur J Nucl Med Mol Imaging. 2011 Jan;38(1):37-45
references: 20717823
references: Clin Cancer Res. 2013 Jul 15;19(14 ):3914-24
references: 23729364
references: Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1400-8
references: 22699524
references: Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):731-5
references: 9845086
references: Nucl Med Biol. 2006 May;33(4):489-94
references: 16720240
references: J Nucl Med. 2008 Jan;49(1):22-9
references: 18077538
references: Nucl Med Commun. 2009 Dec;30(12 ):908-17
references: 19794320
references: J Nucl Med. 2003 Sep;44(9):1426-31
references: 12960187
references: J Nucl Med. 2013 Apr;54(4):499-506
references: 23471314
references: J Nucl Med. 2013 Dec;54(12):2087-92
references: 24136934
references: BMC Cancer. 2006 Mar 04;6:51
references: 16515707
references: Br J Cancer. 1998 Aug;78(4):521-7
references: 9716038
references: Nat Rev Cancer. 2013 Apr;13(4):227-32
references: 23446547
references: J Nucl Med. 2011 Jun;52(6):934-41
references: 21571803
references: Br J Cancer. 2004 Jun 1;90(11):2232-42
references: 15150578
references: Cell. 2011 Mar 4;144(5):646-74
references: 21376230
references: Leuk Lymphoma. 2000 Nov;39(5-6):543-53
references: 11342337
references: Nucl Med Commun. 2012 Oct;33(10 ):1096-102
references: 22836736
references: Eur J Nucl Med Mol Imaging. 2007 Sep;34(9):1339-47
references: 17333178
references: Cancer Res. 2009 May 15;69(10 ):4510-6
references: 19417132
references: Cell. 2009 Aug 21;138(4):645-659
references: 19682730
references: Eur Urol. 2007 Aug;52(2):423-9
references: 17397992
references: J Nucl Med. 2009 May;50 Suppl 1:97S-105S
references: 19403880
references: J Nucl Med. 2013 Mar;54(3):350-7
references: 23359657
references: Radiother Oncol. 2004 Sep;72 (3):333-9
references: 15450733
references: Radiology. 2001 Aug;220(2):373-80
references: 11477239
references: Clin Cancer Res. 2008 Jul 15;14 (14 ):4463-8
references: 18628460
references: Clin Nucl Med. 2013 Jan;38(1):1-6
references: 23242037
references: J Clin Endocrinol Metab. 2006 Apr;91(4):1410-4
references: 16403816
references: Eur Urol. 2013 Jul;64(1):106-17
references: 23628493
references: EJNMMI Res. 2012 Jun 09;2(1):31
references: 22682364
references: Eur J Nucl Med Mol Imaging. 2009 Sep;36(9):1453-9
references: 19387639
references: J Nucl Med. 2013 Nov;54(11):1869-75
references: 24029656
references: BJU Int. 2014 Dec;114(6):818-23
references: 24314065
references: J Nucl Med. 2014 Jul;55(7):1144-9
references: 24777291
references: J Nucl Med. 2005 Mar;46(3):400-4
references: 15750150
references: Proc Natl Acad Sci U S A. 2014 May 20;111(20):7254-9
references: 24785505
references: J Nucl Med. 2010 Jul;51(7):1092-8
references: 20554721
references: J Nucl Med. 2008 Feb;49(2):255-9
references: 18199623
references: Cancer Res. 2011 Aug 1;71(15):5164-74
references: 21646475
references: Cancer Res. 1999 Jan 1;59(1):80-4
references: 9892190
references: Clin Cancer Res. 2006 Jul 1;12(13):3942-9
references: 16818691
references: Radiology. 1994 May;191(2):371-7
references: 8153308
references: J Nucl Med. 2005 Apr;46(4):658-66
references: 15809489
references: BJU Int. 2012 Dec;110(11):1666-71
references: 22520686
references: EJNMMI Res. 2011 Nov 17;1(1):26
references: 22214377
references: Hell J Nucl Med. 2013 May-Aug;16(2):146-7
references: 24032176
references: J Biol Chem. 2011 Nov 25;286(47):41046-56
references: 21937449
references: Immunol Rev. 2008 Apr;222:101-16
references: 18363996
references: Cell. 2006 Jul 14;126(1):107-20
references: 16839880
references: Oral Oncol. 2012 Nov;48(11):1114-9
references: 22704061
references: Eur J Nucl Med Mol Imaging. 2003 Oct;30(10 ):1407-12
references: 12898201
references: J Nucl Med. 2011 Jun;52(6):986-93
references: 21622896
references: Clin Cancer Res. 2009 Sep 1;15(17):5308-16
references: 19706824
references: Nucl Med Commun. 2007 Jun;28(6):473-7
references: 17460538
references: J Nucl Med. 2011 May;52(5):720-5
references: 21498526
references: Clin Pharmacol Ther. 2010 May;87(5):586-92
references: 20357763
references: J Nucl Med. 2008 Jun;49(6):879-86
references: 18483090
references: J Nucl Med. 2013 Mar;54(3):333-40
references: 23401605
references: Mol Imaging Biol. 2014 Oct;16(5):739-46
references: 24696183
references: EJNMMI Res. 2013 Feb 27;3(1):13
references: 23442595
references: Cancer Cell. 2007 Jan;11(1):83-95
references: 17222792
references: J Nucl Med. 2011 Jan;52(1):81-9
references: 21149473
references: Clin Cancer Res. 2012 Mar 1;18(5):1303-12
references: 22170262
references: Cancer. 2008 Jun;112(11):2447-55
references: 18383518
references: J Nucl Med. 2014 Feb;55(2):256-63
references: 24492392
references: Radiother Oncol. 2013 Oct;109 (1):58-64
references: 24044790
references: Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1270-9
references: 24599378
references: Curr Pharm Des. 2008;14 (28):2983-98
references: 18991714
references: Clin Nucl Med. 2009 Dec;34(12 ):952-4
references: 20139848
references: Bioconjug Chem. 2004 Mar-Apr;15(2):373-9
references: 15025534
references: J Med Imaging Radiat Oncol. 2013 Aug;57(4):475-81
references: 23870348
references: J Nucl Med. 2014 Jun;55(6):983-8
references: 24777288
references: J Nucl Med. 2014 Sep;55(9):1424-9
references: 24935990
references: Nucl Med Commun. 2010 Dec;31(12 ):1016-24
references: 20948452
references: J Med Chem. 2013 Sep 12;56(17):6696-708
references: 23947754
references: Ann Nucl Med. 2012 Jul;26(6):478-84
references: 22477262
references: Am J Surg. 1996 Dec;172(6):628-32
references: 8988664
references: Radiology. 2014 Apr;271(1):220-9
references: 24475817
references: Curr Opin Genet Dev. 2005 Feb;15(1):87-96
references: 15661538
references: J Pathol. 2013 Feb;229(3):355-78
references: 22899341
references: Cancer Cell. 2012 Mar 20;21(3):297-308
references: 22439925
references: Nat Med. 2008 Jul;14(7):783-8
references: 18542051
references: Clin Cancer Res. 2008 Nov 15;14 (22):7423-9
references: 19010859
references: Q J Nucl Med Mol Imaging. 2015 Sep;59(3):342-50
references: 24844254
references: J Clin Oncol. 2013 Jun 10;31(17):2205-18
references: 23669226
references: Zhonghua Zhong Liu Za Zhi. 2007 Feb;29(2):127-30
references: 17645850
references: J Nucl Med. 2013 Sep;54(9):1551-6
references: 23949910
references: Ann Neurol. 1985 Jan;17 (1):70-9
references: 3872621
references: Eur J Nucl Med Mol Imaging. 2011 Oct;38(10 ):1816-23
references: 21833840
references: Clin Nucl Med. 2014 Jan;39(1):e59-63
references: 24097008
references: Nat Rev Cancer. 2011 Jun;11(6):393-410
references: 21606941
references: J Urol. 2003 Apr;169(4):1337-40
references: 12629355
references: J Nucl Med. 2005 Jun;46(6):945-52
references: 15937304
references: J Urol. 2002 Jul;168(1):273-80
references: 12050555
references: J Clin Invest. 2008 Dec;118(12):3930-42
references: 19033663
references: J Nucl Med. 2012 May;53(5):787-95
references: 22499613
references: IEEE Eng Med Biol Mag. 2004 Sep-Oct;23(5):57-64
references: 15565800
references: Mol Imaging Biol. 2011 Oct;13(5):853-61
references: 20859697
references: J Nucl Med. 2012 Oct;53(10):1616-24
references: 22935578
references: Eur J Nucl Med Mol Imaging. 2007 Aug;34(8):1316-7; author reply 1318-9
references: 17476505
references: Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):782-7
references: 15183481
references: Eur Radiol. 2009 Jun;19(6):1425-34
references: 19156423
references: J Nucl Med. 2011 Nov;52(11):1803-10
references: 22045709
references: J Clin Oncol. 2002 Sep 15;20(18):3804-14
references: 12228200
references: J Clin Oncol. 2010 Sep 10;28(26):4045-51
references: 20644090
references: Nucl Med Commun. 2013 Feb;34(2):155-61
references: 23196674
references: Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E692-701
references: 24469819
references: Cancer Res. 2009 Oct 1;69(19):7721-8
references: 19773436
references: Clin Cancer Res. 2011 Dec 15;17 (24):7673-83
references: 22038995
references: J Nucl Med. 2012 Nov;53(11):1709-15
references: 23055534
references: Eur J Cancer. 2012 Mar;48(4):432-40
references: 22226480
references: Chem Commun (Camb). 2014 Aug 28;50(67):9557-60
references: 25012592
references: J Nucl Med. 1997 Mar;38(3):343-8
references: 9074514
references: Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):83-9
references: 21095072
references: Eur J Nucl Med Mol Imaging. 2008 Feb;35(2):236-45
references: 17909790
references: Cancer Res. 2010 May 15;70(10 ):3935-44
references: 20460522
references: PLoS One. 2013;8(3):e58938
references: 23554961
references: Mol Pharmacol. 2008 Nov;74(5):1372-80
references: 18669604
references: Eur J Nucl Med Mol Imaging. 2007 Oct;34(10 ):1610-6
references: 17530250
references: Gastroenterology. 2010 Apr;138(4):1429-40
references: 19909745
references: J Nucl Med. 2012 Jan;53(1):29-36
references: 22159180
references: Nucl Med Commun. 2008 Jan;29(1):39-44
references: 18049096
references: Nucl Med Commun. 2013 Dec;34(12 ):1157-65
references: 24100444
references: Nucl Med Commun. 2011 Mar;32(3):168-76
references: 21076343
references: Mol Imaging Biol. 2003 Mar-Apr;5(2):86-93
references: 14499149
references: J Radiat Res. 2013 Nov 1;54(6):1078-84
references: 23589026
references: J Nucl Med. 2004 Mar;45(3):366-73
references: 15001675
references: J Labelled Comp Radiopharm. 2014 Feb;57(2):97-101
references: 24307558
references: Acta Otorhinolaryngol Ital. 1998 Dec;18(6):387-91
references: 10388152
references: Clin Dev Immunol. 2012;2012:708036
references: 22693526
references: Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6610-6
references: 18006761
references: PLoS One. 2013 May 31;8(5):e64570
references: 23741342
references: J Nucl Med. 2008 Mar;49(3):480-508
references: 18287273
references: J Nucl Med. 2002 Feb;43(2):181-6
references: 11850482
references: Cancer Res. 2006 Aug 1;66(15):7621-9
references: 16885362
references: J Nucl Med. 2005 Oct;46(10):1642-9
references: 16204714
references: Clin Cancer Res. 2002 Sep;8(9):2766-74
references: 12231515
references: Eur Radiol. 2012 Jul;22(7):1465-78
references: 22476502
references: Nucl Med Biol. 2012 Aug;39(6):777-84
references: 22444238
references: BMC Cancer. 2013 Feb 22;13:84
references: 23433435
references: J Nucl Med. 2014 Sep;55(9):1506-12
references: 25012458
references: Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14620-5
references: 21873245
references: J Nucl Med. 2014 May;55(5):730-5
references: 24665085
references: Nat Commun. 2014 Jun 03;5:4006
references: 24892406
references: Eur J Nucl Med Mol Imaging. 2014 Apr;41(4):682-93
references: 24504503
references: Eur J Nucl Med Mol Imaging. 2004 May;31(5):720-4
references: 14991243
references: Cancer Res. 1979 Feb;39(2 Pt 1):531-4
references: 761227
references: Nat Med. 1998 Nov;4(11):1334-6
references: 9809561