title: Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein.
abstract: The 37/67-kDa laminin receptor (LAMR/RPSA) was originally identified as a 67-kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular adhesion to the basement membrane. LAMR has evolutionary origins, however, as a 37-kDa RPS2 family ribosomal component. Expressed in all domains of life, RPS2 proteins have been shown to have remarkably diverse physiological roles that vary across species. Contributing to laminin binding, ribosome biogenesis, cytoskeletal organization, and nuclear functions, this protein governs critical cellular processes including growth, survival, migration, protein synthesis, development, and differentiation. Unsurprisingly given its purview, LAMR has been associated with metastatic cancer, neurodegenerative disease and developmental abnormalities. Functioning in a receptor capacity, this protein also confers susceptibility to bacterial and viral infection. LAMR is clearly a molecule of consequence in human disease, directly mediating pathological events that make it a prime target for therapeutic interventions. Despite decades of research, there are still a large number of open questions regarding the cellular biology of LAMR, the nature of its ability to bind laminin, the function of its intrinsically disordered C-terminal region and its conversion from 37 to 67 kDa. This review attempts to convey an in-depth description of the complexity surrounding this multifaceted protein across functional, structural and pathological aspects.
authors: Department of Pathology, New York University School of Medicine, 180 Varick Street, New York, NY 10014, U.S.A.
authors: Vincent
authors: V
authors: DiGiacomo
authors: Department of Pathology, New York University School of Medicine, 180 Varick Street, New York, NY 10014, U.S.A.|NYU Cancer Institute, 550 First Avenue, New York, NY 10016, U.S.A.|NYU Gene Therapy Center, 550 First Avenue, New York, NY 10016, U.S.A.
authors: Daniel
authors: D
authors: Meruelo
mesh_terms: D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007797:Laminin / Q000235:genetics / Q000378:metabolism*; D017474:Receptors, Laminin / Q000235:genetics / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D007797:Laminin; C510624:RPSA protein, human; D017474:Receptors, Laminin; D012269:Ribosomal Proteins
keywords: 37/67 kDa laminin receptor; 37LBP; 37LRP; 67LR; RPSA; YIGSR; p40
references: Breast Cancer Res Treat. 1998;52(1-3):137-45
references: 10066078
references: Biochem Biophys Res Commun. 1999 Mar 16;256(2):385-90
references: 10079194
references: Transfus Clin Biol. 1999 Feb;6(1):7-16
references: 10188208
references: Jpn J Cancer Res. 1999 Apr;90(4):425-31
references: 10363581
references: Br J Cancer. 1999 Jun;80(8):1115-22
references: 10376960
references: Clin Cancer Res. 1999 Jun;5(6):1465-72
references: 10389934
references: J Cell Biochem. 1999 Dec 1;75(3):505-14
references: 10536372
references: Cytometry. 1999 Jan 1;35(1):37-47
references: 10554179
references: J Mol Biol. 2000 May 5;298(3):431-45
references: 10772861
references: Nature. 2000 Sep 21;407(6802):327-39
references: 11014182
references: Exp Eye Res. 2001 Jul;73(1):81-92
references: 11428865
references: Exp Cell Res. 2001 Oct 15;270(1):13-20
references: 11597123
references: EMBO J. 2001 Nov 1;20(21):5863-75
references: 11689427
references: EMBO J. 2001 Nov 1;20(21):5876-86
references: 11689428
references: Bioinformatics. 2002 Feb;18(2):333-4
references: 11847087
references: J Mol Biol. 2002 Feb 22;316(3):725-68
references: 11866529
references: Cancer Res. 2002 Mar 1;62(5):1321-5
references: 11888899
references: J Clin Invest. 2002 Sep;110(5):597-603
references: 12208858
references: Plant Physiol. 1996 Jun;111(2):559-568
references: 12226310
references: Oncogene. 2002 Oct 24;21(49):7478-87
references: 12386810
references: Nat Med. 2002 Dec;8(12):1421-6
references: 12447356
references: J Biol Chem. 2003 May 9;278(19):16857-62
references: 12615923
references: EMBO Rep. 2003 Mar;4(3):290-5
references: 12634848
references: Genes Dev. 2003 Mar 15;17(6):786-99
references: 12651896
references: Biol Chem. 2003 Feb;384(2):243-6
references: 12675517
references: Clin Cancer Res. 2003 Aug 15;9(9):3312-9
references: 12960117
references: Biochem Biophys Res Commun. 1992 Jan 31;182(2):746-52
references: 1310392
references: Proc Natl Acad Sci U S A. 1992 May 15;89(10):4368-72
references: 1374897
references: J Virol. 1992 Aug;66(8):4992-5001
references: 1385835
references: Arch Biochem Biophys. 1992 Aug 15;297(1):132-8
references: 1386213
references: J Biol Chem. 1992 Sep 5;267(25):17743-7
references: 1387642
references: Cancer Res. 1992 Oct 1;52(19):5395-9
references: 1394144
references: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14000-5
references: 14614142
references: Biochem Biophys Res Commun. 2003 Nov 28;311(4):942-7
references: 14623272
references: Nucleic Acids Res. 2003 Dec 1;31(23):6798-805
references: 14627813
references: Nat Genet. 2004 Feb;36(2):123-30
references: 14730304
references: Nat Struct Mol Biol. 2004 Apr;11(4):380-1
references: 15024383
references: Cancer Res. 2004 May 15;64(10):3572-9
references: 15150114
references: Exp Parasitol. 2004 Mar-Apr;106(3-4):95-102
references: 15172216
references: Mol Cell Biol. 2004 Jul;24(13):5797-807
references: 15199136
references: J Biol Chem. 1992 Mar 5;267(7):4974-80
references: 1531660
references: J Biol Chem. 2004 Oct 29;279(44):45662-8
references: 15326169
references: Infect Immun. 1992 Jun;60(6):2337-42
references: 1534073
references: Proteomics. 2004 Nov;4(11):3359-68
references: 15378736
references: J Virol. 2004 Nov;78(22):12647-56
references: 15507651
references: J Biol Chem. 2005 Jan 14;280(2):1360-8
references: 15516338
references: Nat Biotechnol. 2005 Jan;23(1):94-101
references: 15592455
references: Chem Res Toxicol. 2004 Dec;17(12):1706-15
references: 15606148
references: Cell Res. 2005 Mar;15(3):150-9
references: 15780176
references: Biochem Biophys Res Commun. 2005 Jul 15;332(4):1004-11
references: 15922307
references: J Pept Res. 2005 Jul;66(1):9-18
references: 15946191
references: Biochem Biophys Res Commun. 2005 Jul 29;333(2):628-35
references: 15946647
references: Endocr Relat Cancer. 2005 Jun;12(2):393-406
references: 15947111
references: Matrix Biol. 2005 Aug;24(5):326-32
references: 15979864
references: Proteins. 2005 Sep 1;60(4):787-96
references: 16021622
references: Dev Dyn. 2005 Sep;234(1):190-200
references: 16059908
references: Biochem Biophys Res Commun. 2005 Oct 21;336(2):674-81
references: 16140266
references: Biochem Biophys Res Commun. 2005 Dec 2;337(4):1308-18
references: 16236267
references: Biochem Biophys Res Commun. 2005 Dec 23;338(3):1327-34
references: 16263087
references: Science. 2005 Nov 4;310(5749):827-34
references: 16272117
references: Int J Cancer. 2006 May 15;118(10):2421-32
references: 16380995
references: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D158-62
references: 16381836
references: EMBO J. 1983;2(6):861-5
references: 16453457
references: Blood. 2006 Oct 1;108(7):2476-84
references: 16788104
references: J Infect Dis. 2006 Sep 1;194(5):702-9
references: 16897671
references: J Virol. 2006 Oct;80(19):9831-6
references: 16973587
references: Leuk Res. 2007 Sep;31(9):1277-84
references: 17081606
references: J Cell Sci. 1991 Dec;100 ( Pt 4):789-97
references: 1726100
references: Nature. 2007 May 17;447(7142):321-5
references: 17486098
references: Mol Immunol. 2008 Jan;45(1):144-51
references: 17576014
references: J Immunol. 2007 Jul 15;179(2):1381-8
references: 17617631
references: J Mol Recognit. 2008 Jan-Feb;21(1):55-62
references: 18061925
references: J Biol Chem. 2008 Feb 8;283(6):3002-5
references: 18063583
references: J Biol Chem. 2008 Feb 8;283(6):3050-8
references: 18079119
references: Microsc Res Tech. 2008 May;71(5):349-56
references: 18219670
references: Histol Histopathol. 2008 Apr;23(4):487-96
references: 18228206
references: Biochem J. 1991 Mar 1;274 ( Pt 2):535-42
references: 1826081
references: Biosci Rep. 2008 Feb;28(1):33-48
references: 18269348
references: Int J Biochem. 1991;23(1):115-21
references: 1827079
references: Biochem Biophys Res Commun. 1991 May 31;177(1):177-83
references: 1828340
references: Differentiation. 1991 Apr;46(3):173-9
references: 1833253
references: J Biol Chem. 1991 Oct 25;266(30):20440-6
references: 1834645
references: Bioessays. 1991 Sep;13(9):469-73
references: 1839124
references: Biochem Biophys Res Commun. 2008 Jun 20;371(1):172-6
references: 18423375
references: J Immunol. 2008 May 1;180(9):6374-84
references: 18424761
references: Cell Mol Biol Lett. 2008;13(3):452-64
references: 18425431
references: Biochemistry. 1991 Apr 2;30(13):3346-50
references: 1849001
references: Mol Cell Proteomics. 2008 Nov;7(11):2107-22
references: 18565875
references: J Gen Virol. 2008 Aug;89(Pt 8):2055-61
references: 18632978
references: J Neurosci Res. 2009 Feb;87(2):353-9
references: 18798276
references: Genome Biol. 2009;10(1):R2
references: 19123937
references: Am J Physiol Cell Physiol. 2009 Jul;297(1):C121-32
references: 19176763
references: J Neurotrauma. 2009 Feb 11;26(2):195-207
references: 19196078
references: Infect Disord Drug Targets. 2009 Feb;9(1):69-80
references: 19200017
references: PLoS One. 2009;4(2):e4433
references: 19209228
references: J Biol Chem. 2009 Apr 17;284(16):10480-90
references: 19224861
references: Mol Cell Proteomics. 2009 Jun;8(6):1382-90
references: 19240082
references: Biomaterials. 2009 Jun;30(17):3091-9
references: 19268360
references: Am J Physiol. 1991 Oct;261(4 Pt 2):F688-95
references: 1928380
references: J Clin Invest. 2009 Jun;119(6):1638-46
references: 19436113
references: Brain Res Bull. 2009 Aug 14;79(6):402-8
references: 19446013
references: Sci Signal. 2009 May 26;2(72):ra24
references: 19471022
references: Expert Opin Ther Pat. 2009 Jul;19(7):907-17
references: 19514955
references: Exp Mol Med. 2009 Oct 31;41(10):728-36
references: 19561400
references: J Neurosci Res. 1990 Nov;27(3):418-26
references: 1965840
references: Biosci Rep. 2009 Nov 10;30(2):73-9
references: 19691449
references: Mol Ther. 2010 Jan;18(1):63-74
references: 19724263
references: Future Microbiol. 2009 Oct;4(8):959-62
references: 19824788
references: Exp Cell Res. 1991 Apr;193(2):262-73
references: 2004643
references: J Biomed Mater Res A. 2010 Jun 15;93(4):1620-30
references: 20073077
references: Nat Protoc. 2010 Apr;5(4):725-38
references: 20360767
references: Biochem J. 2010 May 13;428(2):133-45
references: 20462400
references: Basic Res Cardiol. 2010 Sep;105(5):621-9
references: 20556404
references: J Cell Biol. 2010 Sep 6;190(5):853-66
references: 20819938
references: Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19754-9
references: 20974910
references: J Mol Biol. 2011 Jan 7;405(1):24-32
references: 21040730
references: Exp Hematol. 2011 Feb;39(2):179-186.e4
references: 21056082
references: Expert Opin Ther Pat. 2011 Jan;21(1):35-53
references: 21110766
references: Biochimie. 2011 Mar;93(3):612-7
references: 21167900
references: Mol Endocrinol. 2011 Feb;25(2):327-38
references: 21193558
references: Science. 2011 Feb 11;331(6018):730-6
references: 21205638
references: Cell Death Dis. 2010;1:e42
references: 21243100
references: PLoS One. 2011 Jan 07;6(1):e15895
references: 21249134
references: J Cell Biol. 1990 Jan;110(1):185-92
references: 2136861
references: Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2):null
references: 21421915
references: Am J Pathol. 1990 Sep;137(3):701-9
references: 2144711
references: Development. 1990 Jul;109(3):521-31
references: 2144817
references: Proc Natl Acad Sci U S A. 1990 Nov;87(21):8570-4
references: 2146686
references: Viruses. 2010 Mar 26;2(4):796-825
references: 21546978
references: Cancer Res. 1990 Jul 1;50(13):4121-30
references: 2162253
references: Prion. 2011 Jul-Sep;5(3):126-37
references: 21862871
references: Prog Biophys Mol Biol. 2011 Sep;106(3):525-36
references: 21867726
references: Nucleic Acids Res. 2012 Jan;40(Database issue):D370-6
references: 21890895
references: J Cell Mol Med. 2012 Jul;16(7):1435-46
references: 21895963
references: Science. 2011 Dec 16;334(6062):1524-9
references: 22096102
references: Structure. 2011 Dec 7;19(12):1784-95
references: 22153501
references: Clin Exp Pharmacol Physiol. 2012 Mar;39(3):265-73
references: 22229384
references: Eur Biophys J. 2012 Mar;41(3):353-8
references: 22290616
references: J Med Virol. 2012 Apr;84(4):615-23
references: 22337301
references: J Mol Biol. 2012 May 25;419(1-2):102-9
references: 22391421
references: Annu Rev Biochem. 2012;81:323-57
references: 22404627
references: Proteins. 2012 Jul;80(7):1715-35
references: 22411565
references: BMC Mol Biol. 2012 Mar 21;13:9
references: 22436005
references: Mol Nutr Food Res. 2012 Apr;56(4):580-92
references: 22495985
references: Biochemistry. 2012 Jun 19;51(24):4807-21
references: 22640394
references: Nat Commun. 2012 Jun 19;3:911
references: 22713753
references: FASEB J. 2012 Oct;26(10):4142-59
references: 22751010
references: Exp Cell Res. 2012 Nov 1;318(18):2365-76
references: 22814251
references: J Proteome Res. 2012 Oct 5;11(10):4863-72
references: 22909348
references: Oncogene. 2013 Aug 15;32(33):3829-39
references: 22964639
references: Infez Med. 2012;20 Suppl 2:8-12
references: 23042000
references: PLoS One. 2012;7(9):e46233
references: 23049988
references: Biosci Rep. 2012 Dec 20;33(1):113-24
references: 23137297
references: Nucleic Acids Res. 2013 Jan;41(2):1284-93
references: 23222135
references: Cell Adh Migr. 2013 Jan-Feb;7(1):48-55
references: 23263632
references: Cell Adh Migr. 2013 Jan-Feb;7(1):150-256
references: 23263633
references: PLoS One. 2013;8(3):e57409
references: 23472084
references: Science. 2013 May 24;340(6135):976-8
references: 23579497
references: Nature. 2013 May 2;497(7447):80-5
references: 23636399
references: FEBS Lett. 2013 Jun 27;587(13):1891-901
references: 23665034
references: Cancer Res. 1990 Aug 1;50(15):4485-96
references: 2369727
references: Dev Biol. 1990 Aug;140(2):318-27
references: 2373256
references: Nat Struct Mol Biol. 2013 Aug;20(8):1015-7
references: 23851459
references: PLoS One. 2013 Aug 22;8(8):e74337
references: 23991217
references: Sci Rep. 2013;3:2702
references: 24048171
references: Sci Rep. 2013;3:2699
references: 24048412
references: J Cell Biol. 1990 Mar;110(3):789-801
references: 2407741
references: Nat Chem Biol. 2014 Jan;10(1):29-34
references: 24212136
references: Proc Natl Acad Sci U S A. 1986 Oct;83(19):7137-41
references: 2429301
references: PLoS One. 2014 Jan 08;9(1):e86013
references: 24416454
references: PLoS One. 2014 Jun 27;9(6):e100373
references: 24972054
references: J Natl Cancer Inst. 1989 May 10;81(10):781-8
references: 2523976
references: J Cell Biol. 1989 Sep;109(3):1351-62
references: 2527859
references: J Cell Biol. 1989 Nov;109(5):2455-62
references: 2530239
references: Biochemistry. 1989 Sep 5;28(18):7476-86
references: 2531008
references: J Biol Chem. 1989 Oct 5;264(28):16652-7
references: 2550450
references: Exp Cell Res. 1985 Jan;156(1):117-26
references: 2578109
references: Cancer Res. 1986 Feb;46(2):807-11
references: 2934129
references: Am J Pathol. 1986 May;123(2):365-70
references: 2939726
references: Cell. 1987 Mar 27;48(6):989-96
references: 2951015
references: Nature. 1987 Sep 17-23;329(6136):261-3
references: 2957596
references: Cancer Res. 1987 Nov 1;47(21):5691-8
references: 2959357
references: Science. 1987 Nov 20;238(4830):1132-4
references: 2961059
references: Biochemistry. 1987 Nov 3;26(22):6896-900
references: 2962631
references: Proc Natl Acad Sci U S A. 1988 Feb;85(4):1282-6
references: 2963341
references: Proteomics. 2009 Jun;9(12):3409-3412
references: 29658196
references: J Cell Biol. 1988 May;106(5):1773-86
references: 2967300
references: Proc Natl Acad Sci U S A. 1988 Sep;85(17):6394-8
references: 2970639
references: J Biol Chem. 1988 Oct 15;263(29):14964-9
references: 2971661
references: J Cell Biol. 1988 Nov;107(5):1873-80
references: 2972733
references: J Biol Chem. 1986 Feb 5;261(4):1883-9
references: 3003087
references: Methods Enzymol. 1987;144:490-507
references: 3041179
references: Nucleic Acids Res. 1988 Mar 25;16(5):2349
references: 3357791
references: J Periodontol. 1986 May;57(5):311-7
references: 3457945
references: Biochem Biophys Res Commun. 1983 Mar 29;111(3):804-8
references: 6301485
references: J Cell Biol. 1983 May;96(5):1475-9
references: 6302102
references: Proc Natl Acad Sci U S A. 1983 Oct;80(19):5927-30
references: 6310604
references: Arch Biochem Biophys. 1982 Nov;219(1):65-70
references: 6758704
references: Hoppe Seylers Z Physiol Chem. 1980 Nov;361(11):1651-60
references: 6778807
references: J Cell Physiol. 1994 May;159(2):263-73
references: 7512975
references: Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7440-4
references: 7519777
references: Clin Exp Metastasis. 1995 Sep;13(5):357-72
references: 7641420
references: Biochemistry. 1995 Sep 5;34(35):11276-87
references: 7669786
references: J Biol Regul Homeost Agents. 1993 Jan-Mar;7(1):22-30
references: 7688491
references: Hum Pathol. 1995 May;26(5):541-6
references: 7750938
references: J Biol Chem. 1995 Jun 2;270(22):13422-8
references: 7768944
references: Cell Adhes Commun. 1994 Jul;2(3):201-9
references: 7827956
references: Arch Virol Suppl. 1994;9:473-84
references: 7913360
references: Genetics. 1993 Oct;135(2):553-64
references: 7916731
references: Cancer Lett. 1994 Sep 30;85(1):133-8
references: 7923097
references: Adv Exp Med Biol. 1994;353:149-54
references: 7985533
references: Gastroenterology. 1994 Sep;107(3):764-72
references: 8076763
references: FEBS Lett. 1994 Feb 28;340(1-2):133-8
references: 8119397
references: Int J Cancer Suppl. 1994;8:116-20
references: 8194888
references: J Biochem. 1994 Feb;115(2):182-9
references: 8206865
references: Biochem Mol Biol Int. 1993 Oct;31(2):201-9
references: 8275010
references: Infect Immun. 1994 Feb;62(2):742-6
references: 8300236
references: Semin Cancer Biol. 1993 Aug;4(4):259-65
references: 8400148
references: Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):635-8
references: 8421699
references: J Natl Cancer Inst. 1993 Feb 3;85(3):235-40
references: 8423629
references: J Natl Cancer Inst. 1993 Mar 3;85(5):398-402
references: 8433393
references: Kidney Int. 1993 Jan;43(1):30-7
references: 8433567
references: Biol Reprod. 1993 Mar;48(3):674-82
references: 8452943
references: Clin Exp Metastasis. 1993 May;11(3):251-61
references: 8472397
references: Biochim Biophys Acta. 1996 Feb 7;1305(1-2):98-104
references: 8605257
references: J Biol Chem. 1996 May 10;271(19):11383-91
references: 8626693
references: J Cell Biochem. 1996 Feb;60(2):226-34
references: 8655633
references: Oncogene. 1996 Aug 1;13(3):495-503
references: 8760291
references: J Virol. 1996 Aug;70(8):5592-9
references: 8764073
references: J Natl Cancer Inst. 1996 Sep 4;88(17):1241-2
references: 8780637
references: J Cell Biochem. 1996 Jun 15;61(4):493-501
references: 8806072
references: Curr Top Microbiol Immunol. 1996;213 ( Pt 1):205-14
references: 8814988
references: J Pathol. 1996 Aug;179(4):376-80
references: 8869283
references: J Med Vet Mycol. 1996 Sep-Oct;34(5):315-22
references: 8912164
references: Tohoku J Exp Med. 1996 Sep;180(1):33-44
references: 8933670
references: Biochem Biophys Res Commun. 1996 Dec 24;229(3):896-901
references: 8954992
references: DNA Cell Biol. 1996 Dec;15(12):1009-23
references: 8985115
references: J Biol Chem. 1997 Jan 24;272(4):2342-5
references: 8999943
references: Matrix Biol. 1996 Dec;15(6):369-81
references: 9049976
references: Int J Biol Markers. 1997 Jan-Mar;12(1):1-5
references: 9176710
references: J Pathol. 1997 May;182(1):36-44
references: 9227340
references: Mol Biochem Parasitol. 1997 Aug;87(2):183-92
references: 9247929
references: J Cell Biochem. 1997 Nov 1;67(2):155-65
references: 9328821
references: Nat Med. 1997 Dec;3(12):1383-8
references: 9396609
references: Zoolog Sci. 1997 Dec;14(6):969-78
references: 9520640
references: J Cell Biochem. 1998 Jun 1;69(3):244-51
references: 9581863
references: Am J Pathol. 1998 May;152(5):1359-65
references: 9588904
references: Mol Biol Evol. 1998 Aug;15(8):1017-25
references: 9718729
references: Biochem Biophys Res Commun. 1998 Oct 20;251(2):564-9
references: 9792813
references: Biochem Biophys Res Commun. 1998 Dec 18;253(2):277-82
references: 9878528
references: Cancer Res. 1999 Feb 1;59(3):704-10
references: 9973221