title: Diabetes to cardiovascular disease: is depression the potential missing link?
abstract: The etiopathological consequences of diabetes and its imperative sequels have been explored extensively in the scientific arena of cardiovascular diabetology. Innumerable risk covariates and confounders have been delineated for the primary and secondary prevention of diabetes and cardiovascular diseases (CVD). However, an intricate interaction of depression on them has been largely overlooked. Depression influences and participates in each and every step that worsens the diabetic state for developing cardiovascular complications. The dilemma is that it coexists, remains silent and generally not considered as relevant clinical parameter amenable to intervention. In this review, it is highlighted that depression has strong association and linkages with both diabetes and CVD and it should be considered and diagnosed at every stage of the diabetes to CVD continuum. Careful attention to the diagnosis and management of these disease states would contribute in lessening the CVD burden of the society.
authors: Department of Human Genetics, Punjabi University, Patiala, India.
authors: Puneetpal
authors: P
authors: Singh
authors: Department of Human Genetics, Punjabi University, Patiala, India.
authors: Shallu
authors: S
authors: Khullar
authors: Department of Human Genetics, Punjabi University, Patiala, India.
authors: Monica
authors: M
authors: Singh
authors: Department of Human Genetics, Punjabi University, Patiala, India.
authors: Gurpreet
authors: G
authors: Kaur
authors: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. Electronic address: S.S.Mastana@lboro.ac.uk.
authors: Sarabjit
authors: S
authors: Mastana
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology*; D003863:Depression / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D048909:Diabetes Complications / Q000150:complications*; D004727:Endothelium / Q000503:physiopathology; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D008954:Models, Biological
chemical_list: D001779:Blood Coagulation Factors