title: Synthesis and biological evaluation of febrifugine analogues.
abstract: A series of febrifugine analogues were designed and synthesized. Antimalarial activity evaluation of the synthetic compounds indicated that these derivatives had a strong inhibition against both chloroquine-sensitive and -resistant Plasmodium falciparum parasites. Many of them were found to be more active than febrifugine hydrochloride. The tested analogues had also a significant cytotoxicity against four cancer cell lines (KB, MCF7, LU1 and HepG2). Among the synthetic analogues, two compounds 17b and 17h displayed a moderate cytotoxicity while they exhibited a remarkable antimalarial activity.
authors: Huong Doan Thi
authors: HD
authors: Mai
authors: Giang Vo
authors: GV
authors: Thanh
authors: Van Hieu
authors: VH
authors: Tran
authors: Van Nam
authors: VN
authors: Vu
authors: Van Loi
authors: VL
authors: Vu
authors: Cong Vinh
authors: CV
authors: Le
authors: Thuy Linh
authors: TL
authors: Nguyen
authors: Thi Dao
authors: TD
authors: Phi
authors: Bich Ngan
authors: BN
authors: Truong
authors: Van Minh
authors: VM
authors: Chau
authors: Van Cuong
authors: VC
authors: Pham
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D010880:Piperidines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D011799:Quinazolines / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D010880:Piperidines; D011799:Quinazolines; C001207:febrifugine