title: Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome.
abstract: Hemorrhagic fever with renal syndrome (HFRS) is an acute viral infectious disease characterized by fever, hemorrhage and renal failure. HFRS has become a serious public health problem in China. Unfortunately, the pathogenesis of HFRS has not been completely clarified. The aim of this study is to investigate the changes of decoy receptor 3 (DcR3) and to further explore its potential roles in HFRS. The levels of serum DcR3 were measured by sandwich ELISA. We found serum DcR3 levels increased significantly, which reached peak value during the oliguric phase and in the critical group. Moreover, serum DcR3 levels were closely related to the levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and parameters reflecting kidney injury including BUN, creatinine (Cr) and proteinuria. This study indicates that high levels of serum DcR3 have associations with the disease stages, severity and degree of kidney damage. Meanwhile, our results suggest that DcR3 may play a dual role in HFRS pathogenesis. First, DcR3 is involved in the inflammatory cascade response resulting in capillary permeability and kidney injury in the early stage. Secondly, HTNV infection induced DcR3 expression at the convalescent phase may act as a feed-back mechanism in anti-inflammatory response. Thus, a study of DcR3 is essential for a better understanding of HFRS pathogenesis.
authors: Department of Immunology and Pathogenic Biology, School of Medicine, Xi'an Jiaotong University, 76 West Yanta Street, Xi'an, 710061, China.
authors: Yanying
authors: Y
authors: Dong
authors: Dongsha
authors: D
authors: Shi
authors: Man
authors: M
authors: Li
authors: Pengfei
authors: P
authors: Dai
authors: Xiangling
authors: X
authors: Wang
authors: Ming
authors: M
authors: Xie
mesh_terms: D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000150:complications; D006801:Humans; D011507:Proteinuria / Q000097:blood / Q000150:complications; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000097:blood*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human; D014409:Tumor Necrosis Factor-alpha; D003404:Creatinine
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