title: Non-contrast myocardial perfusion using a novel 4D magnetic resonance arterial spin labeling technique: initial experience.
abstract: The aim of this study is to develop a novel non-contrast 4-dimensional MR arterial spin labeling (4D-ASL) technique (3D acquisition and time) and to investigate myocardial perfusion on healthy volunteers without administration of contrast materials. A non-contrast 4D-ASL technique was developed using the time-spatial labeling inversion pulse (Time-SLIP) to obtain myocardium perfusion of eight volunteers at 1.5 T. The tagging slab was placed on the proximal ascending aorta to invert the blood magnetization and mid-ventricle 3D images at diastolic phase were acquired with multiple tagging delays. The time resolved 3D images with various inversion times (TI) were registered and segmented for the visualization of myocardial signal changes along the TI, and perfusion curves were generated to identify the perfusion peaks. Blood flow from basal to apical slices was observed in all volunteers. Peak flow at the mid-ventricle was observed 200-400 ms after the blood was tagged at the aortic root blood. After the perfusion peak, all signals returned to the base line. The 4D Time-SLIP technique permits non-contrast perfusion images with high temporal resolution, which may potentially differentiate normal from diseased myocardium.
authors: MR Research, Toshiba Medical Research Institute, Vernon Hills, IL USA. Electronic address: mmiyazaki@tmriusa.com.
authors: Mitsue
authors: M
authors: Miyazaki
authors: MR Research, Toshiba Medical Research Institute, Vernon Hills, IL USA. Electronic address: xzhou@tmriusa.com.
authors: Xiangzhi
authors: X
authors: Zhou
authors: MR Research, Toshiba Medical Research Institute, Vernon Hills, IL USA. Electronic address: bhoshino@tmriusa.com.
authors: Tsutomu
authors: T
authors: Hoshino
authors: Department of Radiology, Kyorin University, School of Medicine, Tokyo, Japan. Electronic address: yokoyama@ks.kyorin-u.ac.jp.
authors: Kenichi
authors: K
authors: Yokoyama
authors: Department of Radiology, Kyorin University, School of Medicine, Tokyo, Japan. Electronic address: rishimura.circ@gmail.com.
authors: Rieko
authors: R
authors: Ishimura
authors: Department of Radiology, Kyorin University, School of Medicine, Tokyo, Japan. Electronic address: nitatori@ks.kyorin-u.ac.jp.
authors: Toshiaki
authors: T
authors: Nitatori
mesh_terms: D000328:Adult; D001158:Arteries / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D055414:Myocardial Perfusion Imaging; D009206:Myocardium / Q000473:pathology*; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels; C427127:superparamagnetic blood pool agent; D052203:Ferrosoferric Oxide
keywords: Arterial spin labeling; Balanced steady state free precession; Non-contrast magnetic resonance cardiac imaging; Non-contrast myocardial perfusion; Time-resolved non-contrast myocardium perfusion curve; Time-spatial labeling inversion pulse (Time-SLIP)