title: Nitrogen-containing bibenzyls from Pleione bulbocodioides: absolute configurations and biological activities.
abstract: Four new pyrrolidone substituted bibenzyls, dusuanlansins A-D (1-4) were isolated from the pseudo bulbs of Pleione bulbocodioides, along with 19 known compounds (5-23). Compounds 1-4 are two pairs of epimers of pyrrolidone substituted bibenzyls, which were separated successfully by a Chiralcel OD-RH C18 column. Their absolute configurations were elucidated by calculated ECD. Biological investigations showed that compounds 5 and 7 exhibited potent anti-inflammatory activities on LPS-stimulated NO production in BV-2 microglial cells, with IC50 values of 2.46 and 3.14μM, respectively.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Yuan
authors: Y
authors: Li
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Fan
authors: F
authors: Zhang
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Ze-Hong
authors: ZH
authors: Wu
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Ke-Wu
authors: KW
authors: Zeng
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Chen
authors: C
authors: Zhang
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Hong-Wei
authors: HW
authors: Jin
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Ming-Bo
authors: MB
authors: Zhao
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors: Yong
authors: Y
authors: Jiang
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: lijun@bjmu.edu.cn.
authors: Jun
authors: J
authors: Li
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: pengfeitu@vip.163.com.
authors: Peng-Fei
authors: PF
authors: Tu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D051379:Mice; D017628:Microglia / Q000187:drug effects*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D029595:Orchidaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D001632:Bibenzyls; D011760:Pyrrolidinones; D009584:Nitrogen
keywords: Anti-inflammatory activity; Bibenzyl; ECD; Epimer; Pleione bulbocodioides