title: Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats.
abstract: Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for spontaneous mutant mouse with non-obstructive hydrocephalus and subcortical heterotopia. Detailed functions of Ccdc85C protein have not been clarified. To reveal roles of Ccdc85C, we examined the distribution and expression pattern of Ccdc85C in the systemic developing organs in rats. Ccdc85C was expressed in various simple epithelia but not stratified epithelia. In the various epithelia, Ccdc85C was localized at cell-cell junctions and its expression was strong at apical junctions. Furthermore, intense expression was seen at developing period and gradually decreased with advancing development. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia.
authors: Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, Japan.
authors: Natsuki
authors: N
authors: Tanaka
authors: Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, Japan.
authors: Takeshi
authors: T
authors: Izawa
authors: Laboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan.
authors: Shigeo
authors: S
authors: Takenaka
authors: Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, Japan.
authors: Jyoji
authors: J
authors: Yamate
authors: Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka, Japan. kuwamura@vet.osakafu-u.ac.jp.
authors: Mitsuru
authors: M
authors: Kuwamura
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D054221:Classical Lissencephalies and Subcortical Band Heterotopias / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006849:Hydrocephalus / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D007365:Intercellular Junctions / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: C000607066:Ccdc85C protein, rat; D050505:Mutant Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger