title: [RUCAM scale-based diagnosis, clinical features and prognosis of 140 cases of drug-induced liver injury].
abstract: OBJECTIVE
  To analyze the etiology, clinical features and prognosis of liver injuries caused by different drugs.
  
  
  METHODS
  The types of suspected drugs related to liver injury, clinical manifestations, liver biochemical parameters, clinical outcomes and other associated data were retrospectively assessed for 140 patients with drug-induced liver injury (DILI). The Roussel Uclaf Causality Assessment Method (RUCAM) was used to assess the causality between drugs and liver injury.
  
  
  RESULTS
  The most prevalent agents inducing DILI were Chinese traditional drugs (62.1%), followed by antipyretic analgesic drugs (10%) and antibiotics (5%). The ratio of male to female patients in the study cohort was 1:1.69, with 71 of the total patients (50.7%) being between the ages of 40 and 60 years-old. The RUCAM scale was not less than 3 points for any of the patients.In general, the clinical manifestations and biochemical results were not specific. The percentages of hepatocellular injury type, cholestatic injury type and mixed injury type were 51.4%, 30.7% and 17.9% respectively. The median age of patients with cholestatic liver injury was 55.6 years, which was older than that of patients with hepatocellular injury (47.1 years) or mixed injury (49.9 years).
  
  
  CONCLUSIONS
  Although antipyretic analgesics and antibiotics are considered as common drugs that can induce DILI, Chinese traditional drugs have emerged as another important group of liver injurious agents. Cholestatic DILI was found to occur more often in elderly patients than in younger patients.
authors: Liver Diseases Center of PLA, the 81th Hospital, Nanjing 210002, China.
authors: Kunyan
authors: K
authors: Hao
authors: Yuecheng
authors: Y
authors: Yu
authors: Changlun
authors: C
authors: He
authors: Maorong
authors: M
authors: Wang
authors: Shouming
authors: S
authors: Wang
authors: Xin
authors: X
authors: Li
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents