title: Population structure of the Chagas disease vector Triatoma infestans in an urban environment.
abstract: Chagas disease is a vector-borne disease endemic in Latin America. Triatoma infestans, a common vector of this disease, has recently expanded its range into rapidly developing cities of Latin America. We aim to identify the environmental features that affect the colonization and dispersal of T. infestans in an urban environment. We amplified 13 commonly used microsatellites from 180 T. infestans samples collected from a sampled transect in the city of Arequipa, Peru, in 2007 and 2011. We assessed the clustering of subpopulations and the effect of distance, sampling year, and city block location on genetic distance among pairs of insects. Despite evidence of genetic similarity, the majority of city blocks are characterized by one dominant insect genotype, suggesting the existence of barriers to dispersal. Our analyses show that streets represent an important barrier to the colonization and dispersion of T. infestans in Arequipa. The genetic data describe a T. infestans infestation history characterized by persistent local dispersal and occasional long-distance migration events that partially parallels the history of urban development.
authors: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors: Camilo E
authors: CE
authors: Khatchikian
authors: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors: Erica A
authors: EA
authors: Foley
authors: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors: Corentin M
authors: CM
authors: Barbu
authors: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors: Josephine
authors: J
authors: Hwang
authors: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors: Jenny
authors: J
authors: Ancca-Juárez
authors: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors: Katty
authors: K
authors: Borrini-Mayori
authors: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors: Victor R
authors: VR
authors: Quıspe-Machaca
authors: Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
authors: Cesar
authors: C
authors: Naquira
authors: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors: Dustin
authors: D
authors: Brisson
authors: Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors: Michael Z
authors: MZ
authors: Levy
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000453:epidemiology / Q000469:parasitology*; D006801:Humans; D007303:Insect Vectors / Q000145:classification* / Q000235:genetics / Q000469:parasitology; D018895:Microsatellite Repeats / Q000235:genetics; D058069:Neglected Diseases / Q000453:epidemiology / Q000469:parasitology*; D010568:Peru / Q000453:epidemiology; D014224:Triatoma / Q000145:classification* / Q000235:genetics / Q000469:parasitology; D014345:Trypanosoma
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