title: Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.
abstract: Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-κB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. d11107022@mail.dlut.edu.cn.
authors: Jingxiao
authors: J
authors: Zhang
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. yanli@dlut.edu.cn.
authors: Yan
authors: Y
authors: Li
authors: System Biology Lab, University of Florida, Gainesville, FL 32608, USA. suchen@cise.ufl.edu.
authors: Su-Shing
authors: SS
authors: Chen
authors: School of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, China. zhanglilei@outlook.com.
authors: Lilei
authors: L
authors: Zhang
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. jhwang_dlut@163.com.
authors: Jinghui
authors: J
authors: Wang
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. yinfengyang@yeah.net.
authors: Yinfeng
authors: Y
authors: Yang
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. zswei@dlut.edu.cn.
authors: Shuwei
authors: S
authors: Zhang
authors: Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China. yqpan@dlut.edu.cn.
authors: Yanqiu
authors: Y
authors: Pan
authors: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling 712100, China. yh_wang@nwsuaf.edu.cn.
authors: Yonghua
authors: Y
authors: Wang
authors: Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. yling@dicp.ac.cn.
authors: Ling
authors: L
authors: Yang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D018938:Caco-2 Cells; D002460:Cell Line; D016208:Databases, Factual; D031983:Eriobotrya / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D010539:Permeability / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D020928:Mitogen-Activated Protein Kinases
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