title: [Two cases of allergies due to Anisakis simplex, positive to specific IgE for Ani s 12 allergen].
abstract: We report 2 cases of immediate allergies to Anisakis after ingestion of seafood. In case 1, after ingestion of flatfish, sea bream and mackerel, wheals and dyspnea occurred. Result of ImmunoCAP was class 5 for Anisakis. ELISA for specific IgE showed that the patient serum strongly reacted to Ani s 12. In case 2, after ingestion of flatfish and yellowtail, pruritus and dyspnea occurred. Result of ImmunoCAP was class 6 for Anisakis. ELISA for specific IgE showed that the patient serum reacted to Ani s 1, 4, 6 and 12. In both cases, skin prick tests were negative for suspected seafoods. These data suggests the possibility Ani s 12 is a major allergen of Anisakis allergy besides Ani s 1, 2 and 7. Ani s 12 is an allergen that was first reported in 2011. The reactivity of Ani s 12 specific IgE with ELISA may become useful for the diagnosis of Anisakis allergy.
authors: Department of Dermatology, Nippon Medical School.
authors: Yuri
authors: Y
authors: Kinoshita
authors: Department of Dermatology, Nippon Medical School.
authors: Kazuhisa
authors: K
authors: Fujimoto
authors: Department of Dermatology, Nippon Medical School.
authors: Min
authors: M
authors: Lee
authors: Department of Dermatology, Nippon Medical School.
authors: Rie
authors: R
authors: Shinohara
authors: Department of Food Science and Technology, Tokyo University of Marine Science and Technology.
authors: Yukihiro
authors: Y
authors: Kobayashi
authors: Department of Dermatology, Nippon Medical School.
authors: Seiji
authors: S
authors: Kawana
authors: Department of Dermatology, Nippon Medical School.
authors: Hidehisa
authors: H
authors: Saeki
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D000818:Animals; D017129:Anisakiasis / Q000276:immunology*; D017163:Anisakis / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D005399:Fishes / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000485:Allergens; D000947:Antigens, Helminth; D007073:Immunoglobulin E