title: A diagnostic approach to recurrent myalgia and rhabdomyolysis in children.
abstract: Episodic myalgia is a common complaint in children and young adults. While many cases remain idiopathic even after extensive investigation, myalgia can be the first symptom of an underlying serious neuromuscular condition, and can be associated with an increased risk of such serious complications as rhabdomyolysis and malignant hyperthermia. We review and highlight the metabolic myopathies and other increasingly recognised muscle disorders that may present to paediatricians with episodic myalgia or isolated episodes of rhabdomyolysis, and propose a diagnostic algorithm for investigation of these complaints.
authors: Children's Neurosciences Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia.
authors: Eunice K
authors: EK
authors: Chan
authors: Children's Neurosciences Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
authors: Andrew J
authors: AJ
authors: Kornberg
authors: Children's Neurosciences Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia Murdoch Childrens Research Institute, Melbourne, Victoria, Australia Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
authors: Monique M
authors: MM
authors: Ryan
mesh_terms: D000659:AMP Deaminase / Q000172:deficiency; D000465:Algorithms; D002648:Child; D004734:Energy Metabolism / Q000502:physiology; D006008:Glycogen Storage Disease / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008064:Lipidoses / Q000150:complications / Q000175:diagnosis; D018482:Muscle, Skeletal / Q000378:metabolism; D063806:Myalgia / Q000175:diagnosis* / Q000209:etiology; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000150:complications / Q000175:diagnosis; D012008:Recurrence; D012206:Rhabdomyolysis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000659:AMP Deaminase
keywords: Glycogen Storage Diseases; Lipidoses; Muscular Diseases; Myalgia; Rhabdomyolysis