title: Association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a Spanish cohort: the Seguimiento Universidad de Navarra project.
abstract: Polychlorinated biphenyls are persistent organic pollutants that are consumed because of their bioaccumulation through the food chain. Evidence from different sources suggests a positive association between polychlorinated biphenyls exposure and the incidence of hypertension. However, no previous prospective study has investigated this potential relationship in adults. We prospectively assessed the association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a large cohort. The Seguimiento Universidad de Navarra project is a Spanish cohort of university graduates, most of them health professionals. We included 14521 participants, initially free of hypertension, who were followed-up for a median of 8.3 years. Dietary intake of polychlorinated biphenyls was assessed at baseline through a previously validated 136-item semiquantitative food frequency questionnaire. The published concentration levels of polychlorinated biphenyls measured in samples of food consumed in Spain were used to estimate dietary intake. Multivariable Cox regression models were fitted to estimate hazard ratios and 95% confidence interval for incident hypertension. During follow-up, 1497 incident cases of medically diagnosed hypertension were identified. After adjusting for total energy intake and for potential confounders, participants in the fifth quintile of total polychlorinated biphenyls intake were at higher risk of developing hypertension (adjusted hazard ratio, 1.43 [95% confidence interval, 1.09-1.88; P for trend 0.017]) compared with those in the first quintile. In this Mediterranean cohort, dietary intake of polychlorinated biphenyls, estimated using a food frequency questionnaire, was associated with a higher risk of developing hypertension during follow-up. Nevertheless, further longitudinal studies are needed to confirm our results.
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
authors: Carolina
authors: C
authors: Donat-Vargas
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
authors: Alfredo
authors: A
authors: Gea
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
authors: Carmen
authors: C
authors: Sayon-Orea
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
authors: Carmen
authors: C
authors: de la Fuente-Arrillaga
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.).
authors: Miguel Angel
authors: MA
authors: Martinez-Gonzalez
authors: From the Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain (C.D.-V., A.G., C.S.-O., C.d.l.F.-A., M.A.M.-G., M.B.-R.); and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain (A.G., C.d.l.F.-A., M.A.M.-G., M.B.-R.). mbes@unav.es.
authors: Maira
authors: M
authors: Bes-Rastrollo
mesh_terms: D000328:Adult; D038441:Diet, Mediterranean / Q000009:adverse effects*; D019587:Dietary Supplements / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D008297:Male; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
keywords: cohort studies; endocrine disrupting chemicals; hypertension; prospective studies