title: There's no such fool like an immunosenescent fool.
abstract: In this issue of Blood, Stepensky et al provide an astute description of immunosenescence arising from deficiency in tripeptidyl peptidase II (TPPII). Senescence of T and B lymphocytes is a striking finding, which has recently come into the limelight because it can be linked to primary immunodeficiency syndromes with autoimmunity.
authors: MEDICAL UNIVERSITY OF GRAZ.
authors: Markus G
authors: http://orcid.org/0000-0003-0981-8661
authors: MG
authors: Seidel
mesh_terms: D000375:Aging / Q000276:immunology*; D000626:Aminopeptidases / Q000276:immunology*; D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics*; D000818:Animals; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000276:immunology*; D005260:Female; D016368:Frameshift Mutation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D008297:Male; D012697:Serine Endopeptidases / Q000276:immunology*; D013921:Thrombocytopenia / Q000235:genetics*
chemical_list: D000626:Aminopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C048001:tripeptidyl-peptidase 2; D012697:Serine Endopeptidases