title: New approaches to managing nonvalvular atrial fibrillation: what are the thromboembolic implications?
abstract: This review addresses current treatment strategies for nonvalvular atrial fibrillation (AF) and their potential impact on thromboembolic risk and complications. It updates current classification schemes for the arrhythmia and discusses specific treatment alternatives including rate control, pharmacologic rhythm suppression, catheter ablation, and left atrial appendage obliteration, each in context of thromboembolic risks and stroke prevention.
authors: Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, 98195-6422, USA, kudenchu@u.washington.edu.
authors: Peter J
authors: PJ
authors: Kudenchuk
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000628:therapy*; D006801:Humans; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*
references: Thromb Haemost. 2011 Oct;106(4):739-49
references: 21789337
references: J Am Coll Cardiol. 2010 Feb 23;55(8):735-43
references: 20170810
references: J Am Coll Cardiol. 2014 Jul 8;64(1):1-12
references: 24998121
references: J Cardiovasc Electrophysiol. 2008 Jun;19(6):575-82
references: 18462324
references: Neuroepidemiology. 2003 Mar-Apr;22(2):118-23
references: 12629277
references: Open Heart. 2014 Jun 06;1(1):e000020
references: 25332785
references: Ann Intern Med. 2007 Jun 19;146(12):857-67
references: 17577005
references: J Cardiovasc Electrophysiol. 2010 Jun 1;21(6):597-605
references: 20384650
references: Circulation. 2012 Aug 14;126(7):806-14
references: 22824434
references: Heart Rhythm. 2014 Sep;11(9):1503-11
references: 24813379
references: Circulation. 2004 Jun 29;109(25):3089-95
references: 15226225
references: Heart Rhythm. 2007 Jun;4(6):816-61
references: 17556213
references: Circulation. 2014 Dec 2;130(23):e199-267
references: 24682347
references: JAMA. 2010 Jan 27;303(4):333-40
references: 20103757
references: Circ Arrhythm Electrophysiol. 2015 Feb;8(1):49-58
references: 25414270
references: Ann Intern Med. 2013 Mar 5;158(5 Pt 1):338-46
references: 23460057
references: Eur Heart J. 2008 Apr;29(8):1037-42
references: 18263865
references: Nat Rev Cardiol. 2014 Nov;11(11):639-54
references: 25113750
references: J Am Coll Cardiol. 2003 Jul 2;42(1):20-9
references: 12849654
references: Vasc Health Risk Manag. 2014;10:1-12
references: 24379678
references: Stroke. 1996 Oct;27(10):1760-4
references: 8841325
references: Circulation. 2014 May 27;129(21):2094-9
references: 24633881
references: J Am Coll Cardiol. 2011 Jan 11;57(2):160-6
references: 21211687
references: Pacing Clin Electrophysiol. 2004 Jul;27(7):983-92
references: 15271020
references: Neurology. 1993 Jan;43(1):32-6
references: 8423907
references: J Am Coll Cardiol. 2004 Jan 7;43(1):47-52
references: 14715182
references: Pacing Clin Electrophysiol. 2013 Feb;36(2):257-65
references: 23078186
references: J Am Coll Cardiol. 2011 Nov 15;58(21):2225-32
references: 22078429
references: Am Heart J. 2005 Aug;150(2):288-93
references: 16086933
references: N Engl J Med. 2008 Jun 19;358(25):2667-77
references: 18565859
references: Int J Clin Pract. 2014 Apr;68(4):444-52
references: 24499075
references: N Engl J Med. 2012 Jan 12;366(2):120-9
references: 22236222
references: Circ Arrhythm Electrophysiol. 2009 Aug;2(4):349-61
references: 19808490
references: Circulation. 2010 Dec 7;122(23):2368-77
references: 21098450
references: J Cardiovasc Electrophysiol. 2010 Oct;21(10):1071-8
references: 20500237
references: Lancet. 1996 Sep 7;348(9028):633-8
references: 8782752
references: Circulation. 2013 Feb 12;127(6):720-9
references: 23325525
references: Eur Heart J. 2010 Oct;31(19):2369-429
references: 20802247
references: N Engl J Med. 2002 Dec 5;347(23):1825-33
references: 12466506
references: N Engl J Med. 2014 Jun 26;370(26):2478-86
references: 24963567
references: JACC Cardiovasc Interv. 2014 Dec;7(12):1333-51
references: 25523529
references: N Engl J Med. 2011 Sep 15;365(11):981-92
references: 21870978
references: J Am Coll Cardiol. 2012 Jan 10;59(2):143-9
references: 22222078
references: Ann Intern Med. 2014 Nov 4;161(9):650-8
references: 25364886
references: Heart Rhythm. 2011 Sep;8(9):1416-23
references: 21699833
references: Heart Rhythm. 2013 Sep;10(9):1272-7
references: 23835257
references: JAMA. 2014 Nov 19;312(19):1988-98
references: 25399274
references: J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2840-8
references: 24814497
references: Am J Cardiol. 2003 Mar 20;91(6A):15D-26D
references: 12670638
references: Ann Thorac Surg. 1996 Feb;61(2):755-9
references: 8572814
references: Lancet. 2006 Jun 10;367 (9526):1903-12
references: 16765759