title: Early-onset pneumonia after out-of-hospital cardiac arrest.
abstract: Early-onset pneumonia (EOP) is a common complication after successful cardiopulmonary resuscitation. Currently, EOP diagnosis is difficult because usual diagnostic tools are blunted by the features of post-cardiac arrest syndrome and therapeutic hypothermia itself. When the diagnosis of EOP is suspected, empiric antimicrobial therapy should be considered following bronchopulmonary sampling. The onset of EOP increases the length of mechanical ventilation duration and intensive care unit stay, but its influence on survival and neurological outcome seems marginal. Therapeutic hypothermia has been recognized as an independent risk factor for this infectious complication. All together, these observations underline the need for future prospective clinical trials to better delineate pathogens and risk factors associated with EOP. In addition, there is a need for diagnostic approaches serving the accurate diagnosis of EOP.
authors: Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Pulmonary Department, Evangelismos, General Hospital of Athens, Greece. Electronic address: sotikaka@yahoo.com.
authors: S
authors: S
authors: Kakavas
authors: Université Paris Est, Faculté de Médecine, Service d'Anesthésie et des Réanimations Chirurgicales, Hôpitaux Universitaires Henri Mondor, Assistance Publique des Hôpitaux de Paris, Créteil, France; Service d'Anesthésie et des Réanimations Chirurgicales, Hôpitaux Universitaires Henri Mondor, Assistance Publique des Hôpitaux de Paris, Université Paris Est, Faculté de Médecine, INSERM U955, Equipe 3, physiopathologie et pharmacologie des insuffisances coronaires et cardiaques, Créteil, France. Electronic address: nicolas.mongardon@hmn.aphp.fr.
authors: N
authors: N
authors: Mongardon
authors: Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Service de Réanimation Médicale, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hôpitaux de Paris, Paris, France; Service de Réanimation Médicale, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, Assistance Publique des Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine; INSERM U970, Paris Cardiovascular Research Centre (PARCC), European Georges Pompidou Hospital, Paris, France. Electronic address: alain.cariou@cch.aphp.fr.
authors: A
authors: A
authors: Cariou
authors: Midwestern University, Downers Grove, IL, USA. Electronic address: dr.anil.gulati@gmail.com.
authors: A
authors: A
authors: Gulati
authors: Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Midwestern University, Downers Grove, IL, USA. Electronic address: theodorosxanthos@yahoo.com.
authors: T
authors: T
authors: Xanthos
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D007362:Intensive Care Units; D007902:Length of Stay; D058687:Out-of-Hospital Cardiac Arrest / Q000150:complications*; D011014:Pneumonia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D012121:Respiration, Artificial; D012307:Risk Factors
keywords: Aspiration; Out-of-hospital cardiac arrest; Pneumonia; Resuscitation; Therapeutic hypothermia