title: Sawtehtetronenin from Goniothalamus sawtehii and its cytotoxicity.
abstract: A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3 ± 11.9 μM and 108.1 ± 1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug.
authors: Chiarpha
authors: C
authors: Thiplueang
authors: Sittiporn
authors: S
authors: Punyanitya
authors: Ratana
authors: R
authors: Banjerdpongchai
authors: Benjawan
authors: B
authors: Wudtiwai
authors: Phansuang
authors: P
authors: Udomputtimekakul
authors: Mongkol
authors: M
authors: Buayairaksa
authors: Narong
authors: N
authors: Nuntasaen
authors: Wilart
authors: W
authors: Pompimon
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D054335:Goniothalamus / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C000595974:Sawtehtetronenin