title: The incidence of type 1 diabetes is still increasing in the Netherlands, but has stabilised in children under five (Young DUDEs-1).
abstract: OBJECTIVE
  This study described the incidence and prevalence of type 1 diabetes in children in the Netherlands in 2010-2011 and to compare these results with earlier studies.
  
  
  METHODS
  This was a retrospective nationwide cohort study of Dutch children aged 14 years or younger. Patients were identified using health insurance reimbursement registries for hospital care and invoices for insulin. In the Netherlands, all children with diabetes are treated by hospital-based paediatricians and health care for all Dutch citizens is covered by law.
  
  
  RESULTS
  The incidence of type 1 diabetes almost doubled between 1978-1980 and 2010-2011, from 11.1 to 21.4 per 100 000. In the youngest age group, who were under 5 years, the incidence rate doubled between 1996 and 1999 and remained stable after that. There were no relevant incidence differences between the sexes. The overall prevalence of type 1 diabetes in the Netherlands during 2009-2011 was 143.6 (95% confidence interval 141.1-146.2) per 100 000 children and was similar for boys and girls.
  
  
  CONCLUSIONS
  The incidence of type 1 diabetes in children in the Netherlands almost doubled between 1978-1980 and 2010-2011, but the incidence in children under 5 years appeared to stabilise between 1996 and 1999. There were no statistical differences between the sexes.
authors: Diabetes Centre, Isala, Zwolle, The Netherlands.|Princess Amalia Children's Clinic, Isala, Zwolle, The Netherlands.
authors: Engelina A J M
authors: EA
authors: Spaans
authors: Vektis, Zeist, The Netherlands.
authors: Lisette M A
authors: LM
authors: Gusdorf
authors: Diabetes Centre, Isala, Zwolle, The Netherlands.|Department of general practice, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors: Klaas H
authors: KH
authors: Groenier
authors: Princess Amalia Children's Clinic, Isala, Zwolle, The Netherlands.|UMCG Postgraduate School of Medicine, University Medical Center and University of Groningen, Groningen, The Netherlands.
authors: Paul L P
authors: PL
authors: Brand
authors: Diabeter, Center for Pediatric and Adolescent Diabetes Care and research, Rotterdam, The Netherlands.
authors: Henk J
authors: HJ
authors: Veeze
authors: Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands.
authors: Hans M
authors: HM
authors: Reeser
authors: Diabetes Centre, Isala, Zwolle, The Netherlands.|Department of internal medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
authors: Henk J G
authors: HJ
authors: Bilo
authors: Diabetes Centre, Isala, Zwolle, The Netherlands.|Department of internal medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.|Langerhans Medical Research Group, Zwolle, The Netherlands.
authors: Nanne
authors: N
authors: Kleefstra
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies
keywords: Children; Diabetes mellitus; Incidence; Prevalence; Type 1 diabetes