title: Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.
abstract: The Tokyo Medical University Hospital in Japan and the Lund University hospital in Sweden have recently initiated a research program with the objective to impact on patient treatment by clinical disease stage characterization (phenotyping), utilizing proteomics sequencing platforms. By sharing clinical experiences, patient treatment principles, and biobank strategies, our respective clinical teams in Japan and Sweden will aid in the development of predictive and drug related protein biomarkers. Data from joint lung cancer studies are presented where protein expression from Neuro- Endocrine lung cancer (LCNEC) phenotype patients can be separated from Small cell- (SCLC) and Large Cell lung cancer (LCC) patients by deep sequencing and spectral counting analysis. LCNEC, a subtype of large cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung carcinoma (SCLC) shares. Pre-therapeutic histological distinction between LCNEC and SCLC has so far been problematic, leading to adverse clinical outcome. An establishment of protein targets characteristic of LCNEC is quite helpful for decision of optimal therapeutic strategy by diagnosing individual patients. Proteoform annotation and clinical biobanking is part of the HUPO initiative (http://www.hupo.org) within chromosome 10 and chromosome 19 consortia.
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan.
authors: Toshihide
authors: T
authors: Nishimura
authors: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-Ku, Tokyo, 153-8904 Japan.
authors: Takeshi
authors: T
authors: Kawamura
authors: Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden.
authors: Yutaka
authors: Y
authors: Sugihara
authors: Biosys Technology, Daihyaku Seimei Toritsudai Ekimae Bldg 5 F 13-18, Nakane 2, Meguro-ku, Tokyo, 152-0031 Japan.
authors: Yasuhiko
authors: Y
authors: Bando
authors: ThermoFisher Scientific, 3-9 Moriya-cho, Kanagawa-ku Yokohama, 221-0022 Japan.
authors: Shigeru
authors: S
authors: Sakamoto
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan.
authors: Masaharu
authors: M
authors: Nomura
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan.
authors: Norihiko
authors: N
authors: Ikeda
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan.
authors: Tatsuo
authors: T
authors: Ohira
authors: National Medical Center for Children and Mothers Research Institute, 2-10-1 Okura Setagaya-ku, Tokyo 157-8535 Japan.
authors: Junichiro
authors: J
authors: Fujimoto
authors: Dept. of Biophysics and Biochemistry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871 Japan.
authors: Hiromasa
authors: H
authors: Tojo
authors: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-Ku, Tokyo, 153-8904 Japan.
authors: Takao
authors: T
authors: Hamakubo
authors: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-Ku, Tokyo, 153-8904 Japan.
authors: Tatsuhiko
authors: T
authors: Kodama
authors: Department of Surgery, Clinical Sciences Lund, Lund University, and Skåne University Hospital, Lund, Sweden 221 84, Lund, Sweden.
authors: Roland
authors: R
authors: Andersson
authors: Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.
authors: Thomas E
authors: TE
authors: Fehniger
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan.
authors: Harubumi
authors: H
authors: Kato
authors: First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, 160-0023 Japan ; Clinical Protein Science & Imaging, Biomedical Center, Dept. of Biomedical Engineering, Lund University, BMC D13, 221 84 Lund, Sweden ; Center of Excellence in Biological and Medical mass spectrometry (CEBMMS), 221 84 Lund, Sweden.
authors: György
authors: G
authors: Marko-Varga
keywords: Biobanking; Cancer diseases; HUPO; MRM; Mass spectrometry; Protein quantification; Proteomics
references: Nat Biotechnol. 2012 Nov;30(11):1065-7
references: 23138303
references: J Proteome Res. 2014 Mar 7;13(3):1315-26
references: 24490776
references: Nat Rev Clin Oncol. 2012 Mar 20;9(5):250
references: 22430855
references: Clin Transl Med. 2013 Feb 06;2(1):4
references: 23388084
references: Electrophoresis. 2008 Jun;29(12):2696-705
references: 18512682
references: Rapid Commun Mass Spectrom. 2002;16(2):117-26
references: 11754257
references: J Proteome Res. 2012 Apr 6;11(4):2005-13
references: 22443261
references: J Proteome Res. 2012 Nov 2;11(11):5124-34
references: 22607352
references: J Transl Med. 2014 Apr 05;12:87
references: 24708694
references: J Proteomics. 2011 Jun 10;74(7):982-92
references: 21440690
references: J Proteomics. 2012 Dec 5;76 Spec No.:116-24
references: 22580359
references: Clin Respir J. 2010 May;4 Suppl 1:1-8
references: 20500603
references: PLoS One. 2011;6(7):e22062
references: 21799770
references: J Proteome Res. 2014 Jan 3;13(1):15-20
references: 24364385
references: Clin Transl Med. 2013 Feb 27;2(1):7
references: 23445834
references: J Proteome Res. 2014 Jan 3;13(1):1-4
references: 24328071
references: Mol Cell Proteomics. 2011 Jul;10(7):M111.009993
references: 21742803
references: J Proteomics. 2011 May 16;74(6):759-64
references: 21184850
references: Nat Rev Clin Oncol. 2011 Aug 23;8(11):661-8
references: 21862980
references: Nat Biotechnol. 2012 Mar 07;30(3):221-3
references: 22398612
references: Int J Proteomics. 2012;2012:921901
references: 22685658
references: Anal Chem. 2011 Nov 1;83(21):8329-36
references: 21942412
references: J Chromatogr B Biomed Sci Appl. 2001 Mar 10;752(2):323-34
references: 11270871
references: J Proteome Res. 2007 Aug;6(8):2925-35
references: 17636986
references: J Proteome Res. 2013 Jan 4;12(1):1-5
references: 23256439
references: J Clin Bioinforma. 2011 Sep 03;1(1):23
references: 21888658
references: Mol Cell Proteomics. 2004 May;3(5):466-77
references: 14766930