title: Prevalence and treatment pattern of Parkinson's disease dementia in Korea.
abstract: OBJECTIVE
  The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD).
  
  
  METHODS
  A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed.
  
  
  RESULTS
  Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used.
  
  
  CONCLUSIONS
  The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Yoon-Sang
authors: YS
authors: Oh
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Joong-Seok
authors: JS
authors: Kim
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: In-Seok
authors: IS
authors: Park
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Yong-Soo
authors: YS
authors: Shim
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: In-Uk
authors: IU
authors: Song
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Jeong-Wook
authors: JW
authors: Park
authors: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors: Phil-Hyu
authors: PH
authors: Lee
authors: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors: Chul-Hyung
authors: CH
authors: Lyoo
authors: Department of Neurology, School of Medicine, Kyung Hee University, Seoul, Korea.
authors: Tae-Beom
authors: TB
authors: Ahn
authors: Department of Neurology, Hallym University College of Medicine, Anyang, Korea.
authors: Hyo-Il
authors: HI
authors: Ma
authors: Department of Neurology, Konyang University Hospital, College of Medicine, Konyang University, Daejeon, Korea.
authors: Yong-Duk
authors: YD
authors: Kim
authors: Department of Neurology, Korea University College of Medicine, Seoul, Korea.
authors: Seong-Beom
authors: SB
authors: Koh
authors: Department of Neurology, Sejong General Hospital, Bucheon, Korea.
authors: Seung-Jae
authors: SJ
authors: Lee
authors: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Kwang-Soo
authors: KS
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology
keywords: Parkinson's disease; cognitive impairment; dementia; prevalence; treatment