title: ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- α and NF- κ B P65.
abstract: ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upregulated in ONFH patients' articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-α and Phospho-NF-κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.
authors: Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China.
authors: Jing-kun
authors: JK
authors: Li
authors: Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China.
authors: Lei
authors: L
authors: Cheng
authors: Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China.
authors: Yun-peng
authors: YP
authors: Zhao
authors: Medical College of Shandong University, Jinan, Shandong 250012, China.
authors: Ying-jun
authors: YJ
authors: Guo
authors: Medical College of Shandong University, Jinan, Shandong 250012, China.
authors: Yi
authors: Y
authors: Liu
authors: Medical College of Shandong University, Jinan, Shandong 250012, China.
authors: Wei
authors: W
authors: Zhang
authors: Medical College of Shandong University, Jinan, Shandong 250012, China.
authors: Shuai-shuai
authors: SS
authors: Wang
authors: Medical College of Shandong University, Jinan, Shandong 250012, China.
authors: Yuan-qiang
authors: YQ
authors: Zhang
authors: Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China.
authors: Xin
authors: X
authors: Pan
authors: Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China.
authors: Lin
authors: L
authors: Nie
mesh_terms: D051722:ADAM Proteins / Q000235:genetics* / Q000378:metabolism*; D000071118:ADAMTS7 Protein; D000368:Aged; D000369:Aged, 80 and over; D002356:Cartilage / Q000378:metabolism*; D005260:Female; D005270:Femur Head / Q000201:enzymology* / Q000503:physiopathology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000503:physiopathology*; D051996:Transcription Factor RelA / Q000378:metabolism*; D048069:Tumor Necrosis Factors / Q000378:metabolism*
chemical_list: D051996:Transcription Factor RelA; D048069:Tumor Necrosis Factors; D051722:ADAM Proteins; D000071118:ADAMTS7 Protein; C121534:ADAMTS7 protein, human
references: J Bone Joint Surg Br. 1972 Nov;54(4):607-14
references: 4639436
references: Clin Orthop Relat Res. 1975 Nov-Dec;(113):178-83
references: 1192666
references: Clin Orthop Relat Res. 1978 Jan-Feb;(130):144-153
references: 639386
references: J Bone Joint Surg Am. 1981 Jan;63(1):131-9
references: 7451514
references: J Bone Joint Surg Br. 1985 Jan;67(1):29-32
references: 3968138
references: J Clin Invest. 2001 Jan;107(1):35-44
references: 11134178
references: J Orthop Res. 2000 Sep;18(5):728-33
references: 11117293
references: Clin Orthop Relat Res. 2001 May;(386):7-10
references: 11347850
references: Nature. 2001 Oct 4;413(6855):488-94
references: 11586351
references: Biochim Biophys Acta. 2003 Apr 15;1626(1-3):83-91
references: 12697333
references: Dev Comp Immunol. 2004 Jun;28(7-8):727-46
references: 15043942
references: Orthop Clin North Am. 2004 Jul;35(3):273-83, vii-viii
references: 15271535
references: J Bone Joint Surg Br. 1985 Jan;67(1):3-9
references: 3155745
references: J Rheumatol. 1987 Feb;14(1):165-70
references: 3106631
references: Clin Orthop Relat Res. 1992 Apr;(277):12-21
references: 1555331
references: J Pediatr Orthop. 1997 Mar-Apr;17(2):266-9
references: 9075107
references: Skeletal Radiol. 1997 Jun;26(6):354-9
references: 9229418
references: J Biol Chem. 1999 Sep 3;274(36):25555-63
references: 10464288
references: J Bone Joint Surg Am. 1966 Jun;48(4):670-701
references: 15580737
references: FASEB J. 2006 May;20(7):988-90
references: 16585064
references: Ocul Immunol Inflamm. 2006 Aug;14(4):215-23
references: 16911983
references: Endothelium. 2006 Jul-Aug;13(4):237-44
references: 16990180
references: Nat Clin Pract Rheumatol. 2008 Mar;4(3):128-35
references: 18253109
references: Nat Clin Pract Rheumatol. 2008 Aug;4(8):420-7
references: 18577998
references: Clin Cancer Res. 2008 Oct 15;14(20):6610-7
references: 18927302
references: Osteoarthritis Cartilage. 2008 Nov;16(11):1413-20
references: 18485748
references: Nat Clin Pract Rheumatol. 2009 Jan;5(1):38-45
references: 19098927
references: Circ Res. 2009 Mar 13;104(5):688-98
references: 19168437
references: Mol Cell Biol. 2009 Aug;29(15):4201-19
references: 19487464
references: J Biol Chem. 2009 Nov 13;284(46):31493-7
references: 19734141
references: Exp Mol Med. 2010 May 31;42(5):376-85
references: 20215856
references: Int J Mol Med. 2010 Jul;26(1):127-33
references: 20514432
references: Clin Exp Rheumatol. 2010 May-Jun;28(3 Suppl 59):S5-12
references: 20576219
references: Arthritis Rheum. 2010 Jul;62(7):2023-36
references: 20506400
references: Nat Rev Rheumatol. 2011 Jan;7(1):33-42
references: 21119608
references: Bone. 2011 Mar 1;48(3):507-13
references: 20950722
references: Science. 2011 Apr 22;332(6028):478-84
references: 21393509
references: J Orthop Res. 2012 Aug;30(8):1238-43
references: 22247065
references: Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2580-8
references: 22995515
references: BMC Musculoskelet Disord. 2014;15:18
references: 24428851
references: J Am Acad Orthop Surg. 2014 Jul;22(7):455-64
references: 24966252
references: Ann Rheum Dis. 2014 Aug;73(8):1575-84
references: 23928557
references: Rheumatology (Oxford). 2014 Dec;53(12):2191-5
references: 24958906