title: Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice.
abstract: Rosmarinic acid (RA), which is a natural polyphenol, was isolated from Rosmarinus. officinalis L. The aim of this study is to evaluate the effects of rosmarinic acid on liver and kidney antioxidant enzymes and the tissue ultrastructure in aging mice. RA was administrated at a dosage of 50, 100 or 200 mg kg(-1) once a day with a normal control group and an aging control group for 30 days. The livers and kidneys of the mice were harvested for antioxidant enzyme activities and histological assessments. RA produced significant (p < 0.05 or p < 0.01) increases in the activity of superoxide dismutase (SOD) catalase (CAT) and glutathione peroxidase (GSH-Px) with a decrease in malondialdehyde (MDA) at 200 mg kg(-1) compared to the aging control. The histopathological study showed RA may induce significant structural changes in liver and kidney tissues at 200 mg kg(-1). The results in this study demonstrate that RA has the potential for promoting in vivo antioxidant enzyme activity.
authors: Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, 150040 Harbin, China. zygorl@aliyun.com.
authors: Ying
authors: Y
authors: Zhang
authors: Xiaoqiang
authors: X
authors: Chen
authors: Lei
authors: L
authors: Yang
authors: Yuangang
authors: Y
authors: Zu
authors: Qi
authors: Q
authors: Lu
mesh_terms: D000375:Aging; D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002681:China; D002934:Cinnamates / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D053630:Depsides / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D019587:Dietary Supplements; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D015227:Lipid Peroxidation; D008099:Liver / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission; D018384:Oxidative Stress; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D027542:Rosmarinus / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D000097123:Rosmarinic Acid
chemical_list: D000975:Antioxidants; D002374:Catalase; D002934:Cinnamates; D053630:Depsides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000097123:Rosmarinic Acid