title: Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.
abstract: OBJECTIVE
  To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates.
  
  
  METHODS
  Descriptive research to develop normative data.
  
  
  METHODS
  Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-held spectral-domain optical coherence tomography. A custom script segmented the RNFL; the fovea and optic nerve center were manually selected. A second script measured the average RNFL thickness along the papillomacular bundle, defined as the arc from -15 degrees to +15 degrees on the axis from the optic nerve to fovea, with radii of 1.1, 1.3, 1.5, and 1.7 mm from the center of the optic disc. Shapiro-Wilk W tests assessed these measurements for normality to determine the age-appropriate radial distance for subsequent analyses. Average RNFL thicknesses for four temporal 45-degree sectors (superior temporal, temporal superior, temporal inferior, and inferior temporal) and the temporal quadrant were calculated and compared to demographic parameters for all infants.
  
  
  RESULTS
  Fifty full-term infants were adequately imaged for RNFL analysis. RNFL thicknesses at 1.5 mm radial distance from the optic nerve were the most normally distributed. While there was a trend toward greater mean superior temporal RNFL thickness for both black and Hispanic vs white infants (128 ± 27 μm, 124 ± 30 μm, and 100 ± 19 μm, respectively, P = .04 for both comparisons), there were no other significant differences noted in RNFL thicknesses by race, sex, gestational age, or birth weight.
  
  
  CONCLUSIONS
  We present RNFL thickness measurements for healthy, full-term infants that may serve as normative data for future analyses.
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Adam L
authors: AL
authors: Rothman
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Monica B
authors: MB
authors: Sevilla
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.
authors: Sharon F
authors: SF
authors: Freedman
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Amy Y
authors: AY
authors: Tong
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Vincent
authors: V
authors: Tai
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Du
authors: D
authors: Tran-Viet
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina; Department of Biomedical Engineering, Duke University, Durham, North Carolina.
authors: Sina
authors: S
authors: Farsiu
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina.
authors: Cynthia A
authors: CA
authors: Toth
authors: Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina; Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina. Electronic address: mays.el-dairi@dm.duke.edu.
authors: Mays A
authors: MA
authors: El-Dairi
mesh_terms: D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D009929:Organ Size; D011446:Prospective Studies; D012016:Reference Values; D012160:Retina / Q000033:anatomy & histology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D047929:Term Birth; D041623:Tomography, Optical Coherence
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