title: The genetic landscape of cardiomyopathy and its role in heart failure.
abstract: Heart failure is highly influenced by heritability, and nearly 100 genes link to familial cardiomyopathy. Despite the marked genetic diversity that underlies these complex cardiovascular phenotypes, several key genes and pathways have emerged. Hypertrophic cardiomyopathy is characterized by increased contractility and a greater energetic cost of cardiac output. Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin. The energetic consequences of these mutations offer molecular targets and opportunities for new drug development and gene correction therapies.
authors: Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: elizabeth.mcnally@northwestern.edu.
authors: Elizabeth M
authors: EM
authors: McNally
authors: Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA.
authors: David Y
authors: DY
authors: Barefield
authors: Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA.
authors: Megan J
authors: MJ
authors: Puckelwartz
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006333:Heart Failure / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans
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