title: Neurogenic cough.
abstract: We review contemporary concepts of the pathophysiology of neurogenic cough, and its evaluation and treatment based on scientific publications addressing neurogenic cough. Neurogenic cough is thought to be the result of sensory neuropathy, most commonly idiopathic. Because it is principally a sensory phenomenon, clinical evaluation is challenging, the diagnosis most often being made by exclusion. Identification of motor paresis, either by laryngoscopy or laryngeal electromyography, may suggest the presence of sensory neuropathy. The utility of amitriptyline and gabapentin has been demonstrated in randomized clinical trials, and retrospective series and case reports have suggested efficacy of pregabalin, baclofen, and botulinum toxin. Sensory neuropathy appears to be an important cause of chronic refractory cough, and appears amenable to treatment with a variety of pharmacologic agents.
authors: Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, Texas.
authors: Kenneth W
authors: KW
authors: Altman
authors: Department of Otolaryngology-Head & Neck Surgery, Boston University Medical Center, Boston, Massachusetts.
authors: J Pieter
authors: JP
authors: Noordzij
authors: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: Clark A
authors: CA
authors: Rosen
authors: Division of Otolaryngology-Head & Neck Surgery, Duke University Medical Center, Durham, North Carolina.
authors: Seth
authors: S
authors: Cohen
authors: Department of Otolaryngology-Head & Neck Surgery, Weill Cornell Medical College, New York, New York.
authors: Lucian
authors: L
authors: Sulica
mesh_terms: D000200:Action Potentials / Q000502:physiology; D003371:Cough / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D004576:Electromyography; D006801:Humans; D007818:Laryngeal Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007830:Larynx / Q000503:physiopathology*
keywords: Cough; laryngeal neuropathy; neurogenic cough; paresis; vagus