title: Platelet-neutrophil interactions under thromboinflammatory conditions.
abstract: Platelets primarily mediate hemostasis and thrombosis, whereas leukocytes are responsible for immune responses. Since platelets interact with leukocytes at the site of vascular injury, thrombosis and vascular inflammation are closely intertwined and occur consecutively. Recent studies using real-time imaging technology demonstrated that platelet-neutrophil interactions on the activated endothelium are an important determinant of microvascular occlusion during thromboinflammatory disease in which inflammation is coupled to thrombosis. Although the major receptors and counter receptors have been identified, it remains poorly understood how heterotypic platelet-neutrophil interactions are regulated under disease conditions. This review discusses our current understanding of the regulatory mechanisms of platelet-neutrophil interactions in thromboinflammatory disease.
authors: Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, Chicago, IL, 60612, USA.
authors: Jing
authors: J
authors: Li
authors: Kyungho
authors: K
authors: Kim
authors: Andrew
authors: A
authors: Barazia
authors: Alan
authors: A
authors: Tseng
authors: Jaehyung
authors: J
authors: Cho
mesh_terms: D000755:Anemia, Sickle Cell / Q000378:metabolism / Q000473:pathology; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D002450:Cell Communication; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D017382:Reactive Oxygen Species
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