title: PI3Kβ inhibition: all that glitters is not gold.
abstract: In this issue of Blood, Laurent et al demonstrate that phosphatidylinositol 3-kinase β (PI3Kβ) activity is essential for thrombus stability at a high shear rate, highlighting a potential risk of embolization upon PI3Kβ inhibition.
authors: UNIVERSITY OF PAVIA.
authors: Mauro
authors: M
authors: Torti
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D058534:Class I Phosphatidylinositol 3-Kinases / Q000235:genetics*; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D006801:Humans; D013927:Thrombosis / Q000235:genetics*
chemical_list: C509622:1-phosphatidylinositol 3-kinase p110 subunit, mouse; D058534:Class I Phosphatidylinositol 3-Kinases; D038362:Glycogen Synthase Kinase 3