title: Effect of tumor deposits on overall survival in colorectal cancer patients with regional lymph node metastases.
abstract: OBJECTIVE
  The staging system of the International Union Against Cancer considers tumor deposits to be N1c in patients with no regional lymph node metastasis, but the significance of tumor deposits in patients with regional lymph node metastases is unclear. We investigated the effect of tumor deposits on overall survival in colorectal cancer patients with regional lymph node metastases.
  
  
  METHODS
  From 2000 to 2008, 551 patients underwent resections for colorectal cancer at our medical center. We excluded 87 patients who had distant metastases or had received neoadjuvant chemotherapy or radiotherapy from our study and statistically analyzed the remaining 464 patients.
  
  
  RESULTS
  Stepwise multivariate Cox proportional hazards analysis in patients with regional lymph node metastases showed only tumor deposits to be significant for overall survival (hazard ratio: 2.813; P = 0.0002). Recurrence was seen in 49.2% of patients with tumor deposits (30/61) compared with 14.4% of patients without them (58/403; P < 0.0001). Tumor deposits did not show the same effect on overall survival as lymph node metastases.
  
  
  CONCLUSIONS
  Tumor deposits were significantly associated with poorer overall survival in colorectal cancer patients with regional lymph node metastases. The effect of tumor deposits on overall survival was between that of lymph node metastasis and distant metastasis.
authors: Department of Surgery, JA Toride Medical Center, Japan.
authors: Eiichi
authors: E
authors: Yabata
authors: Department of Surgery, JA Toride Medical Center, Japan.
authors: Masaru
authors: M
authors: Udagawa
authors: Department of Surgery, JA Toride Medical Center, Japan.
authors: Hiroyuki
authors: H
authors: Okamoto
keywords: colorectal cancer; lymph node metastasis; overall survival; tumor deposits
references: Mod Pathol. 2009 Mar;22(3):410-5
references: 19136930
references: Dis Colon Rectum. 2011 Aug;54(8):982-8
references: 21730787
references: Ann Surg. 1994 Apr;219(4):365-73
references: 8161262
references: Br J Surg. 1982 Oct;69(10):613-6
references: 6751457
references: Mod Pathol. 2007 Aug;20(8):843-55
references: 17491597
references: Int J Clin Oncol. 2012 Feb;17(1):1-29
references: 22002491
references: J Clin Oncol. 2011 Jun 20;29(18):2550-6
references: 21576644
references: Cancer. 2000 May 15;88(10):2228-38
references: 10820343
references: Surg Today. 1997;27(7):617-22
references: 9306563
references: Histopathology. 2007 Aug;51(2):141-9
references: 17532768
references: J Clin Oncol. 2011 Jun 20;29(18):2487-92
references: 21555695
references: Dis Colon Rectum. 2003 Nov;46(11):1531-7
references: 14605575
references: Dis Colon Rectum. 2002 Jun;45(6):733-42; discussion 742-3
references: 12072622
references: Am J Clin Pathol. 2010 Mar;133(3):388-94
references: 20154277
references: Ann Surg. 2012 Feb;255(2):208-13
references: 21527844
references: Surg Today. 2005;35(5):377-84
references: 15864419
references: Dis Colon Rectum. 2010 May;53(5):771-8
references: 20389211
references: Am J Clin Pathol. 2007 Feb;127(2):287-94
references: 17210518