title: Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody.
abstract: "Formes frustes" of encephalopathy associated with anti-NMDAR antibody have been recently described in cases of chronic epilepsy. We report a young woman with a parietal lesion and anti-NMDAR antibody who acquired bilateral, secondary epileptogenesis in the temporal lobes within a period as short as six years. Removal of the primary epileptogenic lesion of oligoastrocytoma in the right parietal lobe resulted in seizure freedom, disappearance of secondary foci, and substantial decrease of the antibody titre. Chronic exposure to anti-NMDAR antibody, albeit at a low titre, may have resulted in a smoldering chronic course and relatively early acquisition of "reversible" secondary foci without development of a high degree of epileptogenicity and structural changes.
authors: Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto.
authors: Riki
authors: R
authors: Matsumoto
authors: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan.
authors: Nobuhiro
authors: N
authors: Mikuni
authors: Department of Neurology, Kanazawa Medical University, Ishikawa.
authors: Keiko
authors: K
authors: Tanaka
authors: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto.
authors: Kiyohide
authors: K
authors: Usami
authors: Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto.
authors: Kenjiro
authors: K
authors: Fukao
authors: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto.
authors: Takeharu
authors: T
authors: Kunieda
authors: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka.
authors: Yukitoshi
authors: Y
authors: Takahashi
authors: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto.
authors: Susumu
authors: S
authors: Miyamoto
authors: Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto.
authors: Hidenao
authors: H
authors: Fukuyama
authors: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto.
authors: Ryosuke
authors: R
authors: Takahashi
authors: Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto.
authors: Akio
authors: A
authors: Ikeda
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000150:complications*; D001323:Autoantibodies / Q000276:immunology*; D001932:Brain Neoplasms / Q000150:complications*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D012640:Seizures / Q000209:etiology* / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate
keywords: anti-NMDAR antibody; autoimmune epilepsy; oligoastrocytoma; secondary epileptogenesis