title: Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT.
abstract: Neuronal variability in sensory cortex predicts perceptual decisions. This relationship, termed choice probability (CP), can arise from sensory variability biasing behaviour and from top-down signals reflecting behaviour. To investigate the interaction of these mechanisms during the decision-making process, we use a hierarchical network model composed of reciprocally connected sensory and integration circuits. Consistent with monkey behaviour in a fixed-duration motion discrimination task, the model integrates sensory evidence transiently, giving rise to a decaying bottom-up CP component. However, the dynamics of the hierarchical loop recruits a concurrently rising top-down component, resulting in sustained CP. We compute the CP time-course of neurons in the medial temporal area (MT) and find an early transient component and a separate late contribution reflecting decision build-up. The stability of individual CPs and the dynamics of noise correlations further support this decomposition. Our model provides a unified understanding of the circuit dynamics linking neural and behavioural variability.
authors: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló 149, 08036 Barcelona, Spain.
authors: Klaus
authors: K
authors: Wimmer
authors: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló 149, 08036 Barcelona, Spain.
authors: Albert
authors: A
authors: Compte
authors: 1] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló 149, 08036 Barcelona, Spain [2] Centre de Recerca Matemàtica (CRM), Campus de Bellaterra, Edifici C, 08193 Barcelona, Spain.
authors: Alex
authors: A
authors: Roxin
authors: 1] Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal [2] Department of Neurobiology, Stanford University, 299 Campus Drive West , Stanford, California 94305-5125, USA.
authors: Diogo
authors: D
authors: Peixoto
authors: Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.
authors: Alfonso
authors: A
authors: Renart
authors: Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló 149, 08036 Barcelona, Spain.
authors: Jaime
authors: J
authors: de la Rocha
mesh_terms: D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D003657:Decision Making / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D008960:Models, Psychological; D009039:Motion Perception / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D010775:Photic Stimulation; D011336:Probability; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology
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