title: Mantle cell lymphoma: observation to transplantation.
abstract: Mantle cell lymphoma as a rare non-Hodgkin B-cell lymphoma can present in different clinical presentations such as an aggressive form or a more indolent picture. Treatment modality is based on multiple factors including age, presence or absence of symptoms, and comorbidities. Watchful waiting is a reasonable approach for asymptomatic patients especially in elderly. In symptomatic patients, treatment is chemo-immunotherapy followed by maintenance immunotherapy or autologous bone marrow transplant. Allogeneic bone marrow transplant has a potential benefit of cure for relapsed/refractory cases, but it has a high mortality rate. Novel treatment with agents such as ibrutinib, a Bruton tyrosine kinase inhibitor, has shown promising results in relapse/refractory cases. We extensively review the most recent data on diagnostic and therapeutic management of mantle cell lymphoma through presenting two extreme clinical scenarios.
authors: University of Nevada School of Medicine, 2040 West Charleston Boulevard, Las Vegas, NV 89102, USA.
authors: Babak
authors: B
authors: Rajabi
authors: Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
authors: John W
authors: JW
authors: Sweetenham
keywords: chemo-immunotherapy; ibrutinib; mantle cell lymphoma; transplantation
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