title: Functional outcome, cognition and quality of life after out-of-hospital cardiac arrest and therapeutic hypothermia: data from a randomized controlled trial.
abstract: BACKGROUND
  To study functional neurologic and cognitive outcome and health-related quality of life (HRQoL) in a cohort of patients included in a randomised controlled trial on glucose control following out-of-hospital cardiac arrest (OHCA) from ventricular fibrillation (VF) treated with therapeutic hypothermia.
  
  
  METHODS
  Patients alive at 6 months after being discharged from the hospital underwent clinical neurological and extensive neuropsychological examinations. Functional outcome was evaluated with the Cerebral Performance Category scale, the modified Rankin scale and the Barthel Index. Cognitive outcome was evaluated by neuropsychological test battery including two measures of each cognitive function: cognitive speed, execution, memory, verbal skills and visuospatial performance. We also assessed quality of life with a HRQoL 15D questionnaire.
  
  
  RESULTS
  Of 90 OHCA-VF patients included in the original trial, 57 were alive at 6 months. Of these, 52 (91%) were functionally independent and 54 (95%) lived at their previous home. Focal neurological deficits were scarce. Intact cognitive performance was observed in 20 (49%), mild to moderate deficits in 14 (34%) and severe cognitive deficits in 7 (17%) of 41 patients assessed by a neuropsychologist. Cognitive impairments were most frequently detected in executive and memory functions. HRQoL of the CA survivors was comparable to that of age- and gender matched population.
  
  
  CONCLUSIONS
  Functional outcome six months after OHCA and therapeutic hypothermia was good in the great majority of the survivors, and half of them were cognitively intact. Of note, the HRQoL of CA survivors did not differ from that of age- and gender matched population.
authors: Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4, Helsinki, 00029, Finland. marjaana.tiainen@hus.fi.
authors: Marjaana
authors: M
authors: Tiainen
authors: Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4, Helsinki, 00029, Finland. erja.poutiainen@helsinki.fi.|Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland. erja.poutiainen@helsinki.fi.
authors: Erja
authors: E
authors: Poutiainen
authors: Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. tuomas.oksanen@hus.fi.
authors: Tuomas
authors: T
authors: Oksanen
authors: Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. maija.kaukonen@hus.fi.
authors: Kirsi-Maija
authors: KM
authors: Kaukonen
authors: Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. ville.pettila@hus.fi.
authors: Ville
authors: V
authors: Pettilä
authors: Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. markus.skrifvars@hus.fi.
authors: Markus
authors: M
authors: Skrifvars
authors: Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. tero.varpula@hus.fi.
authors: Tero
authors: T
authors: Varpula
authors: Karolinska Institutet, Institution of Clinical Science and Education and Stockholm, Stockholm, Sweden. maaret.castren@sodersjukhuset.se.|Helsinki University and HUCH Emergency Care, Helsinki University Hospital, Helsinki, Finland. maaret.castren@sodersjukhuset.se.
authors: Maaret
authors: M
authors: Castrén
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D058687:Out-of-Hospital Cardiac Arrest / Q000209:etiology / Q000628:therapy*; D011788:Quality of Life; D020127:Recovery of Function; D016019:Survival Analysis; D016896:Treatment Outcome
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