title: Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.
abstract: In this study, we focused on the anti-inflammatory effect of cordycepin, 3'-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin.
authors: a Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , Japan.
authors: Kenta
authors: K
authors: Imamura
authors: Momoko
authors: M
authors: Asai
authors: Kazuhiro
authors: K
authors: Sugamoto
authors: Tomoko
authors: T
authors: Matsumoto
authors: Yumi
authors: Y
authors: Yamasaki
authors: Ichiro
authors: I
authors: Kamei
authors: Takahiro
authors: T
authors: Hattori
authors: Masaoki
authors: M
authors: Kishimoto
authors: Seiji
authors: S
authors: Niisaka
authors: Masaomi
authors: M
authors: Kubo
authors: Kazuo
authors: K
authors: Nishiyama
authors: Masao
authors: M
authors: Yamasaki
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology*; D003839:Deoxyadenosines / Q000378:metabolism / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D000067996:RAW 264.7 Cells
chemical_list: D000893:Anti-Inflammatory Agents; D003839:Deoxyadenosines; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C058120:cordycepin
keywords: RAW 264.7 cells; adenosine kinase; adenosine receptor; cordycepin; nitric oxide