title: Neurogenic inflammation and colliquative lymphadenitis with persistent orthopox virus DNA detection in a human case of cowpox virus infection transmitted by a domestic cat.
abstract: Cowpox viruses are orthopoxviruses that may survive in the environment for years. Rodents are regarded as the primary hosts, but transmission to other species has been reported. This report describes a cowpox virus infection in a cat with subsequent transmission to its owner leading to protracted, atypical and severe clinical signs. A young cat presented with multiple crusts and plaques on the neck, muzzle and tail base. The owner developed an erythematous lesion with elevated margins, central necrosis and crust formation below the left breast, a neurogenic inflammation, enlarged regional lymph nodes, a colliquative lymphadenitis and concomitant flu-like symptoms. Cultures were taken at the first visit from the cat's lesional skin and the patient's skin, and polymerase chain reaction with sequencing of the haemagglutinin region of both were positive for cowpox virus. The patient was treated with various antibiotics and methylprednisolone and was in clinical remission after 7 months.
authors: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: S
authors: S
authors: Hobi
authors: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: R S
authors: RS
authors: Mueller
authors: Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: M
authors: M
authors: Hill
authors: Robert Koch Institute, Consultant Laboratory for Pox Virus, Centre for Biologic Threats and Special Pathogens 1, Berlin, Germany.
authors: A
authors: A
authors: Nitsche
authors: Department of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: T
authors: T
authors: Löscher
authors: Department of Infectious Diseases and Tropical Medicine, Schwabing Hospital, Munich, Germany.
authors: W
authors: W
authors: Guggemos
authors: Department of Dermatology, University of Münster, Münster, Germany.
authors: S
authors: S
authors: Ständer
authors: Department of Clinical Radiology, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: D
authors: D
authors: Rjosk-Dendorfer
authors: Department of Dermatology and Allergology, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
authors: A
authors: A
authors: Wollenberg
mesh_terms: D000328:Adult; D000818:Animals; D000829:Animals, Domestic; D001365:Axilla; D002415:Cats; D015605:Cowpox / Q000635:transmission*; D015608:Cowpox virus / Q000235:genetics / Q000302:isolation & purification; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008199:Lymphadenitis / Q000821:virology*; D020078:Neurogenic Inflammation / Q000821:virology*
chemical_list: D004279:DNA, Viral