title: Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa.
abstract: A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.
authors: Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. ma4949@cgmh.org.tw.
authors: Wu-Fu
authors: WF
authors: Chen
authors: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. bear790516@gmail.com.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. bear790516@gmail.com.
authors: Chen-Ting
authors: CT
authors: Yin
authors: Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. ma4200@cgmh.org.tw.
authors: Ching-Hsiao
authors: CH
authors: Cheng
authors: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
authors: Mei-Chin
authors: MC
authors: Lu
authors: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors: Lee-Shing
authors: LS
authors: Fang
authors: Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. whw@mail.nsysu.edu.tw.
authors: Wei-Hsien
authors: WH
authors: Wang
authors: Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
authors: Zhi-Hong
authors: ZH
authors: Wen
authors: Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
authors: Jih-Jung
authors: JJ
authors: Chen
authors: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
authors: Yang-Chang
authors: YC
authors: Wu
authors: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
authors: Ping-Jyun
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004224:Diterpenes
references: Cancer Res. 1988 Sep 1;48(17):4827-33
references: 3409223
references: J Nat Prod. 1989 Sep-Oct;52(5):1143-5
references: 2575139
references: Org Lett. 2005 Aug 18;7(17):3813-6
references: 16092882
references: Chem Pharm Bull (Tokyo). 2007 Apr;55(4):537-40
references: 17409543
references: Cancer Res. 1988 Feb 1;48(3):589-601
references: 3335022
references: Mar Drugs. 2011;9(10):1860-86
references: 22073000
references: Mar Drugs. 2014 Jun;12(6):3371-80
references: 24897385
references: J Nat Prod. 2002 Dec;65(12):1904-8
references: 12502336
references: Bioorg Med Chem. 2009 Mar 15;17(6):2181-4
references: 19036594