title: Epidermal nevi with aberrant epidermal structure in keratinocytes and melanocytes.
abstract: Epidermal nevi are congenital cutaneous hamartomas caused by embryonic somatic mutations. Ultrastructural features of adult epidermal nevi have rarely been investigated. Herein, we report a case involving a Japanese adult who had epidermal nevi with right congenital blindness and a right accessory nipple. The histopathologic and ultrastructural studies showed divergent abnormal epidermal structures in both melanocytes and keratinocytes. Our case indicates the need to further investigate histopathologic, ultrastructural, and genetic associations in adult epidermal nevi.
authors: Department of Dermatology, Faculty of Medicine, Kinki University, Osaka-Sayama, Japan.
authors: Naoki
authors: N
authors: Oiso
authors: Koji
authors: K
authors: Sugawara
authors: Ayano
authors: A
authors: Yonamine
authors: Daisuke
authors: D
authors: Tsuruta
authors: Akira
authors: A
authors: Kawada
mesh_terms: D000328:Adult; D005260:Female; D006222:Hamartoma / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D008544:Melanocytes / Q000473:pathology; D009506:Nevus / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
keywords: cutaneous hamartoma; electron microscopy; epidermal nevus; keratinocytes; melanocytes