title: Synthesis of novel triazoles, tetrazine, thiadiazoles and their biological activities.
abstract: An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved. The synthesized compounds were characterized by spectroscopic and elemental analyses, and screened for their antibacterial activities against four different strains, namely E. coli, P. aeruginosa, S. aureus and B. megaterium. In particular, the compounds 5, 24 and 26h exhibited excellent antibacterial activities compared to the reference antibiotic. To get further insight about their behavior, these compounds were tested for their antioxidant activities via SOD-like activity, DPPH free radical scavenging activity, ABST and NO, which showed promising results. Furthermore, these compounds effectively promoted the cleavage of genomic DNA as well, in the absence of any external additives.
authors: Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia. alomair@kfu.edu.sa.
authors: Mohammed A
authors: MA
authors: Al-Omair
authors: Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia. arsayed@kfu.edu.sa.|Department of Chemistry, Faculty of Science, University of Beni Suef, Beni Suef 62511, Egypt. arsayed@kfu.edu.sa.
authors: Abdelwahed R
authors: AR
authors: Sayed
authors: Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia. mmm_youssef@yahoo.com.|Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. mmm_youssef@yahoo.com.
authors: Magdy M
authors: MM
authors: Youssef
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects; D053837:DNA Cleavage; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009569:Nitric Oxide / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D006573:Heterocyclic Compounds, 1-Ring; D013830:Thiadiazoles; D014230:Triazoles; D009569:Nitric Oxide
references: Molecules. 2012 Apr 13;17(4):4460-73
references: 22504831
references: Eur J Med Chem. 2014 Sep 12;84:491-504
references: 25050881
references: Free Radic Biol Med. 1999 May;26(9-10):1231-7
references: 10381194
references: Molecules. 2013 May 29;18(6):6366-82
references: 23760033
references: Molecules. 2013 Mar 19;18(3):3562-76
references: 23519199
references: J Org Chem. 2012 Dec 21;77(24):11119-31
references: 23205621
references: Am J Clin Pathol. 1966 Apr;45(4):493-6
references: 5325707
references: Eur J Med Chem. 2002 Mar;37(3):197-206
references: 11900864
references: Pharmazie. 1989 Dec;44(12):820-2
references: 2635319
references: Farmaco. 2002 Feb;57(2):171-4
references: 11902660
references: J Fluoresc. 2013 May;23(3):503-8
references: 23408090
references: Anal Biochem. 1982 Oct;126(1):131-8
references: 7181105
references: J Clin Oncol. 1995 Apr;13(4):910-3
references: 7707118
references: Chem Biol Drug Des. 2011 Oct;78(4):689-94
references: 21816005
references: Molecules. 2010 Apr 09;15(4):2526-50
references: 20428062
references: J Org Chem. 2002 Feb 22;67(4):1084-92
references: 11846648
references: Molecules. 2012 Sep 12;17(9):11010-25
references: 22971585
references: J Pharm Pharmacol. 1997 Jan;49(1):105-7
references: 9120760
references: Eur J Med Chem. 2010 May;45(5):1919-26
references: 20149495
references: Eur J Med Chem. 2012 Oct;56:254-62
references: 23022735