title: A selective colorimetric and fluorescent sensor for Al3+ ion and its application to cellular imaging.
abstract: A new rhodamine-based fluorescent turn-on chemosensor (L) for selective detection of Al3+ ion has been developed and characterized. The fluorescent chemosensor L was synthesized by the reaction of intermediate (4) with 2,5-bis (4-phenylacyl chloride)-1,3,4-oxadiazole (3). The chemosensor L displays an excellent selective and sensitive response to Al3+ ion over other metal ions, in which the spirocyclic (non-fluorescent) to ring opened amide (fluorescent) process was utilized and a 1:2 stoichiometry for L-Al3+ complex was formed with an association constant of 2.03×10(3) M(-1). Furthermore, chemosensor L can be applied as a fluorescent probe for monitoring Al3+ in living cells by performing cell imaging studies.
authors: Department of Chemistry, Anna University, Chennai 600 025, India.
authors: Rangasamy
authors: R
authors: Manjunath
authors: Department of Chemistry, Anna University, Chennai 600 025, India.
authors: Elango
authors: E
authors: Hrishikesan
authors: Department of Chemistry, Anna University, Chennai 600 025, India. Electronic address: pakannan@annauniv.edu.
authors: Palaninathan
authors: P
authors: Kannan
mesh_terms: D000535:Aluminum / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology; D002412:Cations / Q000032:analysis; D045744:Cell Line, Tumor; D003124:Colorimetry / Q000379:methods; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D061848:Optical Imaging / Q000379:methods*; D012235:Rhodamines / Q000737:chemistry*
chemical_list: D002412:Cations; D005456:Fluorescent Dyes; D012235:Rhodamines; D000535:Aluminum
keywords: Aluminum(III) ion; Chemosensor; Naked eye; Rhodamine B