title: Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats.
abstract: Activity of matrix metalloproteinase-9 increases following cerebral ischemia/reperfusion, and is associated with cerebral microvascular permeability, blood-brain barrier destruction, inflammatory cell infiltration and brain edema. Matrix metalloproteinase-9 also likely participates in thrombolysis. A rat model of middle cerebral artery infarction was established by injecting autologous blood clots into the internal carotid artery. At 3 hours following model induction, urokinase was injected into the caudal vein. Decreased neurological severity score, reduced infarct volume, and increased expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were observed in the cerebral cortex 24 hours after urokinase thrombolysis. These results suggest that urokinase can suppress damage in the acute-early stage of cerebral infarction.
authors: Department of Neurology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China.
authors: Yuqiang
authors: Y
authors: Song
authors: Qingdao Central Hospital, Qingdao 266042, Shandong Province, China.
authors: Hongli
authors: H
authors: Zou
authors: Qingdao No. 9 People's Hospital, Qingdao 266003, Shandong Province, China.
authors: Guofeng
authors: G
authors: Wang
authors: The Second Hospital of Shandong University, Jinan 255000, Shandong Province, China.
authors: Hongxia
authors: H
authors: Yang
authors: The Second Hospital of Shandong University, Jinan 255000, Shandong Province, China.
authors: Zhaohong
authors: Z
authors: Xie
authors: The Second Hospital of Shandong University, Jinan 255000, Shandong Province, China.
authors: Jianzhong
authors: J
authors: Bi
keywords: cerebral infarction; matrix metalloproteinase-9; neural regeneration; thrombolysis; tissue inhibitor of metalloproteinase-1; urokinase
references: Ann Indian Acad Neurol. 2008 Oct;11(4):221-4
references: 19893677
references: Curr Top Med Chem. 2009;9(14):1240-60
references: 19849665
references: J Neurosci Res. 2010 Apr;88(5):1017-25
references: 19885863
references: AJNR Am J Neuroradiol. 2010 Sep;31(8):1536-40
references: 20395391
references: J Neurosci. 2005 Jul 6;25(27):6401-8
references: 16000631
references: J Neurosci. 2004 Jan 21;24(3):671-8
references: 14736853
references: Stroke. 2003 Apr;34(4):925-31
references: 12649522
references: Neurol Res. 2009 Mar;31(2):204-8
references: 19298763
references: Stroke. 2003 Aug;34(8):2025-30
references: 12855824
references: Neurosci Lett. 2011 Feb 1;489(1):16-9
references: 21129442
references: J Neurochem. 2009 Feb;108(3):811-20
references: 19187098
references: Brain Res. 2008 Aug 11;1224:12-9
references: 18573239
references: Transl Stroke Res. 2010 Sep 1;1(3):220-9
references: 21666857
references: Neurol Res. 2009 May;31(4):367-70
references: 19508820
references: J Neurotrauma. 2009 Nov;26(11):1935-41
references: 19469687
references: Neuroscience. 2008 Jan 24;151(2):340-51
references: 18160227
references: Open Neurol J. 2008 Oct 31;2:55-65
references: 19452012
references: Neurol Sci. 2010 Apr;31(2):223-5
references: 19816656
references: Matrix Biol. 2009 Apr;28(3):148-59
references: 19264129
references: BMC Neurosci. 2008 Dec 10;9:117
references: 19077183
references: Behav Brain Res. 2011 Sep 30;223(1):17-23
references: 21419805
references: J Cereb Blood Flow Metab. 2000 Dec;20(12):1681-9
references: 11129784
references: Neurochem Res. 2011 Nov;36(11):2022-8
references: 21678122
references: Brain Res. 1997 Dec 5;778(1):16-24
references: 9462873
references: Curr Cardiol Rev. 2010 Aug;6(3):218-26
references: 21804781
references: Stroke. 2001 Aug;32(8):1759-66
references: 11486102
references: J Pineal Res. 2010 Nov;49(4):332-41
references: 20663046