title: Forever Young(er): potential age-defying effects of long-term meditation on gray matter atrophy.
abstract: While overall life expectancy has been increasing, the human brain still begins deteriorating after the first two decades of life and continues degrading further with increasing age. Thus, techniques that diminish the negative impact of aging on the brain are desirable. Existing research, although scarce, suggests meditation to be an attractive candidate in the quest for an accessible and inexpensive, efficacious remedy. Here, we examined the link between age and cerebral gray matter re-analyzing a large sample (n = 100) of long-term meditators and control subjects aged between 24 and 77 years. When correlating global and local gray matter with age, we detected negative correlations within both controls and meditators, suggesting a decline over time. However, the slopes of the regression lines were steeper and the correlation coefficients were stronger in controls than in meditators. Moreover, the age-affected brain regions were much more extended in controls than in meditators, with significant group-by-age interactions in numerous clusters throughout the brain. Altogether, these findings seem to suggest less age-related gray matter atrophy in long-term meditation practitioners.
authors: Department of Neurology, School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
authors: Eileen
authors: E
authors: Luders
authors: Centre for Research on Ageing Health and Wellbeing, Australian National University Canberra, ACT, Australia.
authors: Nicolas
authors: N
authors: Cherbuin
authors: Department of Neurology, School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
authors: Florian
authors: F
authors: Kurth
keywords: MRI; VBM; aging; brain; gray matter; meditation; mindfulness
references: Neuroimage. 2004 Sep;23(1):84-97
references: 15325355
references: Neurology. 2005 Mar 22;64(6):1032-9
references: 15781822
references: Soc Cogn Affect Neurosci. 2008 Mar;3(1):55-61
references: 19015095
references: J Neuroimaging. 2014 Mar-Apr;24(2):187-90
references: 23773541
references: Birth Defects Res C Embryo Today. 2010 Dec;90(4):284-96
references: 21181889
references: Front Psychol. 2014 Sep 23;5:1083
references: 25295025
references: Hum Brain Mapp. 2013 Dec;34(12):3369-75
references: 22815233
references: Front Hum Neurosci. 2012 Feb 29;6:34
references: 22393318
references: Ageing Res Rev. 2005 May;4(2):141-94
references: 15996533
references: Cereb Cortex. 2014 Jun;24(6):1609-18
references: 23389995
references: Emotion. 2010 Feb;10(1):43-53
references: 20141301
references: Front Psychol. 2013 Jul 09;4:398
references: 23847572
references: Neurobiol Aging. 2007 Oct;28(10):1623-7
references: 17655980
references: Ann N Y Acad Sci. 2014 Jan;1307:112-23
references: 23924172
references: Psychiatry Res. 2011 Jan 30;191(1):36-43
references: 21071182
references: Neuroimage. 2007 Oct 15;38(1):95-113
references: 17761438
references: Neuroimage. 2011 Aug 15;57(4):1308-16
references: 21664467
references: Neuroreport. 2005 Nov 28;16(17):1893-7
references: 16272874
references: Ann N Y Acad Sci. 2014 Jan;1307:82-8
references: 23924195
references: Soc Cogn Affect Neurosci. 2013 Jan;8(1):27-33
references: 22569185
references: Ann N Y Acad Sci. 2014 Jan;1307:89-103
references: 24571182
references: Neuroimage. 2009 Apr 15;45(3):672-8
references: 19280691
references: PLoS Biol. 2007 Jun;5(6):e138
references: 17488185
references: Neurobiol Aging. 2011 May;32(5):916-32
references: 19570593
references: Soc Cogn Affect Neurosci. 2013 Jan;8(1):34-9
references: 22814662
references: Biol Psychol. 2013 Feb;92(2):275-81
references: 23046904
references: Front Hum Neurosci. 2011 Feb 10;5:17
references: 21347275
references: Front Psychol. 2012 Apr 18;3:116
references: 22529832
references: Neuroreport. 2009 Jan 28;20(2):170-4
references: 19104459
references: Neurobiol Aging. 2014 Jan;35(1):35-41
references: 23932882
references: Hippocampus. 2013 Jun;23(6):437-50
references: 23460346
references: J Neurosci. 2009 Oct 21;29(42):13418-27
references: 19846729
references: Nat Rev Immunol. 2011 Aug 05;11(9):625-32
references: 21818124
references: Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85
references: 18282566
references: Front Aging Neurosci. 2010 Nov 29;2:150
references: 21151819
references: Trends Cogn Sci. 2008 Apr;12(4):163-9
references: 18329323
references: Front Behav Neurosci. 2014 Jan 27;8:17
references: 24478663