title: Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.
abstract: Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.
authors: Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, CO 80206, USA.
authors: Samantha F
authors: SF
authors: Friend
authors: Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Department of Biology, Regis University Denver, CO 80221, USA.
authors: Francina
authors: F
authors: Deason-Towne
authors: Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, CO 80206, USA.
authors: Lisa K
authors: LK
authors: Peterson
authors: Takeda Pharmaceuticals International Co. Cambridge, MA 02139, USA.
authors: Allison J
authors: AJ
authors: Berger
authors: Department of Pediatrics, University of Colorado School of Medicine Aurora, CO 80045, USA ; Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, CO 80206, USA ; Division of Rheumatology, Colorado Children's Hospital Aurora, CO 80045, USA ; Since completing this study, Dr. Dragone has joined Genentech, a member of the Roche group. Genentech South San Francisco, CA 94090, USA.
authors: Leonard L
authors: LL
authors: Dragone
keywords: MLN4924; NEDD8; SLAP; SUMO; T cell; c-Cbl; ubiquitin
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