title: Transmitted drug resistance to rilpivirine in newly diagnosed antiretroviral naive adults.
abstract: We characterized transmitted drug resistance to rilpivirine and the predicted efficacy of first-line rilpivirine-containing regimens in antiretroviral-naive Spanish patients. International Antiviral Society-USA mutations were detected in 138 of 2781 patients (4.9%), E138A (3.4%) being the most prevalent. Using the Stanford Algorithm, 121 patients (4.4%) showed low-level or intermediate resistance. No differences in the predicted efficacy of first-line non-nucleoside reverse transcriptase inhibitor-based regimens were observed. As rilpivirine becomes more widely used in clinical practice, the evolution of its transmitted drug resistance will need to be monitored. In addition, the exact role of E138A singletons on rilpivirine activity as part of first-line regimens merits further evaluation.
authors: San Cecilio University Hospital, Granada, Spain.
authors: M
authors: M
authors: Alvarez
authors: National Centre of Epidemiology, Madrid, Spain.
authors: S
authors: S
authors: Monge
authors: San Cecilio University Hospital, Granada, Spain.
authors: N
authors: N
authors: Chueca
authors: San Cecilio University Hospital, Granada, Spain.
authors: V
authors: V
authors: Guillot
authors: Hospital Universitario Virgen del Rocio, Sevilla, Spain.
authors: P
authors: P
authors: Viciana
authors: Hospital Carlos III, Madrid, Spain.
authors: L
authors: L
authors: Anta
authors: Centro Sandoval, Madrid, Spain.
authors: C
authors: C
authors: Rodriguez
authors: Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors: J L
authors: JL
authors: Gomez-Sirvent
authors: Hospital Parc Taulí, Sabadell, Barcelona, Spain.
authors: G
authors: G
authors: Navarro
authors: Hospital de la Princesa, Madrid, Spain.
authors: I
authors: I
authors: de los Santos
authors: Hospital Ramón y Cajal, Madrid, Spain.
authors: S
authors: S
authors: Moreno
authors: San Cecilio University Hospital, Granada, Spain. Electronic address: fegarcia@ugr.es.
authors: F
authors: F
authors: García
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D009570:Nitriles / Q000494:pharmacology*; D015995:Prevalence; D011743:Pyrimidines / Q000494:pharmacology*; D000068696:Rilpivirine
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D011743:Pyrimidines; D000068696:Rilpivirine
keywords: Naive adults; resistance mutations; rilpivirine; therapeutic barrier