title: [Cognitive Function and Calcium. NMDA receptor activity dependent intracellular Ca increase in neurons].
abstract: Many studies have suggested that NMDAR have critical roles in the mechanisms for learning and memory. They are also thought to be involved in neuronal dysfunctions and mental disorders. Since NMDARs have high permeability to Ca2+, most studies indicate that Ca influx through NMDAR ion channels are important to mediate various neuronal activities and intracellular signaling pathways. Our research have shown that intracellular Ca2+ increase during NMDAR dependent depolarization is a secondary process via voltage gated calcium channels.
authors: Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Japan.
authors: Yoshiaki
authors: Y
authors: Oda
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D044169:Receptors, Calcium-Sensing / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D044169:Receptors, Calcium-Sensing; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium