title: Systems biology approach to understanding post-traumatic stress disorder.
abstract: Post-traumatic stress disorder (PTSD) is a psychological disorder affecting individuals that have experienced life-changing traumatic events. The symptoms of PTSD experienced by these subjects-including acute anxiety, flashbacks, and hyper-arousal-disrupt their normal functioning. Although PTSD is still categorized as a psychological disorder, recent years have witnessed a multi-directional research effort attempting to understand the biomolecular origins of the disorder. This review begins by providing a brief overview of the known biological underpinnings of the disorder resulting from studies using structural and functional neuroimaging, endocrinology, and genetic and epigenetic assays. Next, we discuss the systems biology approach, which is often used to gain mechanistic insights from the wealth of available high-throughput experimental data. Finally, we provide an overview of the current computational tools used to decipher the heterogeneous types of molecular data collected in the study of PTSD.
authors: Institute of Collaborative Biotechnologies, University of California Santa Barbara, Santa Barbara, California, USA.
authors: Gunjan S
authors: GS
authors: Thakur
authors: Bernie J
authors: BJ
authors: Daigle
authors: Kelsey R
authors: KR
authors: Dean
authors: Yuanyang
authors: Y
authors: Zhang
authors: Maria
authors: M
authors: Rodriguez-Fernandez
authors: Rasha
authors: R
authors: Hammamieh
authors: Ruoting
authors: R
authors: Yang
authors: Marti
authors: M
authors: Jett
authors: Joseph
authors: J
authors: Palma
authors: Linda R
authors: LR
authors: Petzold
authors: Francis J
authors: FJ
authors: Doyle
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D051379:Mice; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D049490:Systems Biology; D014481:United States