title: Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction.
abstract: Epigenetic silencing of tumor suppressor genes by promoter methylation plays vital roles in the process of carcinogenesis. The purpose of this meta-analysis was to determine whether the aberrant methylation of cyclin A1 (CCNA1) may be of great significance to human malignant tumors. By searching both English and Chinese language-based electronic databases carefully, we tabulated and analyzed parameters from each study. All human-associated case-control studies were included providing available data for CCNA1 methylation and reporting the adjusted odds ratios (ORs) and 95% confidence intervals (CI) conducted with the use of Version 12.0 STATA software. A total of 10 case-control studies (619 patients with cancers and 292 healthy controls) were included for the following statistical analysis. Pooled OR values from all articles revealed that the frequency of CCNA1 methylation in cancer tissues was significantly higher than those of normal tissues (P < 0.001). Further ethnicity indicated that the frequency of CCNA1 methylation was correlated with the development of malignant tumors among all those included experimental subgroups (all P < 0.05). These data from results indicated a significant connection of CCNA1 methylation with poor progression in human malignant tumors among both Caucasian and Asian populations.
authors: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Bin
authors: B
authors: Yang
authors: Department of Geriatrics, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Shuai
authors: S
authors: Miao
authors: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Le-Ning
authors: LN
authors: Zhang
authors: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Hong-Bin
authors: HB
authors: Sun
authors: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Zhe-Nan
authors: ZN
authors: Xu
authors: Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Chun-Shan
authors: CS
authors: Han
mesh_terms: D056750:Cyclin A1 / Q000235:genetics*; D019175:DNA Methylation; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D011401:Promoter Regions, Genetic; D017594:Publication Bias
chemical_list: C503745:CCNA1 protein, human; D056750:Cyclin A1
references: Cancer Res. 1997 Mar 1;57(5):913-20
references: 9041194
references: Head Neck. 2014 May;36(5):631-7
references: 23595968
references: World J Gastroenterol. 2004 Dec 1;10(23):3441-54
references: 15526363
references: Bioinformatics. 2005 Sep 15;21(18):3672-3
references: 15955784
references: JAMA. 2006 Feb 8;295(6):676-80
references: 16467236
references: BMC Cancer. 2006;6:55
references: 16524460
references: J Clin Endocrinol Metab. 2006 Dec;91(12):4798-804
references: 17018661
references: Am J Epidemiol. 2007 Mar 15;165(6):667-76
references: 17204515
references: Clin Cancer Res. 2007 Dec 15;13(24):7296-304
references: 18094410
references: Oral Oncol. 2008 Apr;44(4):400-6
references: 17689134
references: Langenbecks Arch Surg. 2008 Jul;393(4):535-45
references: 18193270
references: Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-94
references: 18843024
references: Nat Rev Drug Discov. 2009 Jul;8(7):547-66
references: 19568282
references: Cell Oncol. 2010;32(1-2):131-43
references: 20208141
references: Eur J Epidemiol. 2010 Sep;25(9):603-5
references: 20652370
references: Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2272-7
references: 20660602
references: J Clin Oncol. 2010 Sep 10;28(26):4074-80
references: 20644095
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Expert Rev Vaccines. 2011 Mar;10(3):389-95
references: 21434806
references: Lung Cancer. 2011 Jul;73(1):32-7
references: 21145615
references: Mol Carcinog. 2011 Sep;50(9):680-8
references: 21563216
references: Cell Cycle. 2012 Mar 15;11(6):1123-30
references: 22370483
references: PLoS Med. 2012;9(5):e1001216
references: 22675273
references: Stat Med. 2012 Dec 20;31(29):3805-20
references: 22763950
references: CA Cancer J Clin. 2013 Jan;63(1):11-30
references: 23335087
references: Development. 2013 Aug;140(15):3079-93
references: 23861057
references: PLoS One. 2013;8(8):e72210
references: 23991063
references: Cell Mol Life Sci. 2002 Aug;59(8):1317-26
references: 12363035
references: Cell Res. 2003 Oct;13(5):319-33
references: 14672555
references: Cancer Res. 2003 Dec 1;63(23):8323-9
references: 14678992
references: Clin Cancer Res. 2004 Aug 1;10(15):4944-58
references: 15297395
references: Cancer Res. 2004 Sep 1;64(17):5982-7
references: 15342377
references: Mol Cell Biol. 2004 Oct;24(20):8917-28
references: 15456866
references: J Transl Med. 2013;11:316
references: 24359512
references: J Biol Chem. 1999 Apr 16;274(16):11220-8
references: 10196209