title: SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population.
abstract: OBJECTIVE
  Synaptosomal-associated protein of 25 kDa (SNAP25) is a member of the soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) protein complex, which plays essential roles in the modulation of different voltage-gated calcium channels and neurotransmitter release. Many previous studies have reported the SNAP25 gene to be significantly associated with attention-deficit/hyperactivity disorder (ADHD). Recently, shared genetic variants have been demonstrated in 5 major psychiatric disorders, including schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorders, and ADHD. However, no compelling, convincing evidence has suggested an association between SNAP25 and schizophrenia or major depressive disorder. Thus, we investigated the association between SNAP25 and both schizophrenia and major depressive disorder in the Han Chinese population.
  
  
  METHODS
  We performed a large-scale case-control study to test the association between SNAP25 and 2 major mental disorders, schizophrenia (DSM-IV criteria) and major depressive disorder (DSM-IV criteria), in the Han Chinese population. Seven single-nucleotide polymorphisms (SNPs) were genotyped in 1,330 schizophrenia patients, 1,045 major depressive disorder patients, and 1,520 healthy controls of Han Chinese origin.
  
  
  RESULTS
  Two SNPs, rs3787283 and rs3746544, were found to be associated with both schizophrenia (rs3746544, adjusted P = .00257) and major depressive disorder (rs3746544, adjusted P = .0485; rs3787283, adjusted P = .00387) in this study. The AG haplotype consisting of rs3787283 and rs3746544 was also significantly associated with both schizophrenia and major depressive disorder (schizophrenia: adjusted P = .0126; major depressive disorder: adjusted P = .000580). Additionally, we carried out a meta-analysis of the current data and published association results and further confirmed the association between rs3746544 and schizophrenia (Pmeta = .002, ORmeta = 1.213 [95% CI, 1.077-1.367]).
  
  
  CONCLUSIONS
  Our results indicated that SNPs in SNAP25 represented a common risk factor of both schizophrenia and major depressive disorder in the Han Chinese population.
authors: Department of Psychiatry, the First Teaching Hospital of Xinjiang Medical University, Urumqi.
authors: Qingzhong
authors: Q
authors: Wang
authors: Yanlin
authors: Y
authors: Wang
authors: Weidong
authors: W
authors: Ji
authors: Guoquan
authors: G
authors: Zhou
authors: Kuanjun
authors: K
authors: He
authors: Zhiqiang
authors: Z
authors: Li
authors: Jianhua
authors: J
authors: Chen
authors: Wenjin
authors: W
authors: Li
authors: Zujia
authors: Z
authors: Wen
authors: Jiawei
authors: J
authors: Shen
authors: Yu
authors: Y
authors: Qiang
authors: Jue
authors: J
authors: Ji
authors: Yujiong
authors: Y
authors: Wang
authors: Yongyong
authors: Y
authors: Shi
authors: Qizhong
authors: Q
authors: Yi
authors: Yonggang
authors: Y
authors: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003865:Major Depressive Disorder / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*
chemical_list: D050825:Synaptosomal-Associated Protein 25