title: Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.
abstract: A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitaminAin them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120 µg/g diet for 4 weeks) failed to improve the plasma concentration of vitaminA. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency.
authors: Department of Agricultural. Food and Nutritional Science.
authors: Prisca
authors: P
authors: Tuitoek
authors: Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2P5.
authors: Jonathan
authors: J
authors: Lakey
authors: Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2P5.
authors: Ray
authors: R
authors: Rajotte
authors: Division of life Sciences, The University of Texas at San Antonio, San Antonio, Texas 78249-0662, U.S.A.
authors: Shahed
authors: S
authors: Ziari
authors: Division of life Sciences, The University of Texas at San Antonio, San Antonio, Texas 78249-0662, U.S.A.
authors: Andrew
authors: A
authors: Tsin
authors: Department of Agricultural. Food and Nutritional Science.
authors: Tapan
authors: T
authors: Basu
keywords: dietary zinc effect; insulin effect; streptozotocin-induced diabetes; vitamin A status
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