title: Resolution of diols via catalytic asymmetric acetalization.
abstract: A highly enantioselective kinetic resolution of diols via asymmetric acetalization has been achieved using a chiral confined imidodiphosphoric acid catalyst. The reaction is highly efficient for the resolution of tertiary alcohols, giving selectivity factors of up to >300. Remarkably, even in cases where the selectivity factors are only moderate, highly enantioenriched diols are obtained via a stereodivergent resolution to diastereomeric acetals.
authors: Max-Planck-Institut für Kohlenforschung , Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors: Ji Hye
authors: JH
authors: Kim
authors: Ilija
authors: I
authors: Čorić
authors: Chiara
authors: C
authors: Palumbo
authors: Benjamin
authors: B
authors: List
mesh_terms: D000080:Acetals / Q000737:chemistry*; D002384:Catalysis; D006018:Glycols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D006018:Glycols