title: Quantification of low drug concentration in model formulations with multivariate analysis using surface enhanced Raman chemical imaging.
abstract: This paper reports the application of surface enhanced Raman chemical imaging (SER-CI) as a potentially non-destructive quantitative analytical method for the investigation of model pharmaceutical formulations containing the active pharmaceutical ingredient (API) in low concentrations (0.5-2%). The application of chemometric techniques for processing the spectra enables the determination of API distribution in products of different concentrations. In addition, the applied multivariate curve resolution can be proper method to identify unexpected contaminants in illicit drugs. The drastic Raman signal enhancement in the presence of silver nanoparticles provides significantly improved calibration accuracy and, at the same time, radically decreased image acquisition time compared to conventional Raman chemical imaging.
authors: Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, H-1111 Budapest, Hungary. Electronic address: firkala.tamas@gmail.com.
authors: Tamás
authors: T
authors: Firkala
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8, H-1111 Budapest, Hungary.
authors: Attila
authors: A
authors: Farkas
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8, H-1111 Budapest, Hungary.
authors: Balázs
authors: B
authors: Vajna
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8, H-1111 Budapest, Hungary.
authors: Zsombor Kristóf
authors: ZK
authors: Nagy
authors: Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, H-1111 Budapest, Hungary.
authors: György
authors: G
authors: Pokol
authors: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budafoki út 8, H-1111 Budapest, Hungary.
authors: György
authors: G
authors: Marosi
authors: Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, H-1111 Budapest, Hungary; MTA-BME Technical Analytical Chemistry Research Group, Szt. Gellért tér 4, H-1111 Budapest, Hungary.
authors: Imre Miklós
authors: IM
authors: Szilágyi
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D015999:Multivariate Analysis; D053758:Nanoparticles / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations; D012834:Silver
keywords: Chemometrics; R-CI; Raman chemical imaging; SER-CI; SERS