title: Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy.
abstract: OBJECTIVE
  Coagulation abnormalities, endothelial dysfunction and arteriosclerosis play a key role in cardiovascular disease state observed in transplanted patients. Plasma adiponectin levels are lower following kidney transplantation. However, there is still a debate about this topic in the literature. This study evaluated, adiponectin levels associated with markers of endothelial dysfunction and platelet function in renal transplant patients.
  
  
  METHODS
  Sixty-six renal transplant patients were studied. Patients were grouped according to immunosuppression regimen. Group 1 (n = 36) were treated with cyclosporine A based regimes and group 2 (n = 30) were treated with tacrolimus based regimes. Plasma adiponectin, asymmetric dimethyl arginine (ADMA), sP-selectin levels and platelet aggregation tests were studied and were compared with those in control group (n = 15, group 3).
  
  
  RESULTS
  Adiponectin, sP-selectin and ADMA levels were higher in group 1 and statistically significant differences were observed compared with those of group 2 and group 3, respectively (P < 0.001, P < 0.05, P < 0.05). Platelet aggregation values induced by agonists were lower in group 1 than group 2 and group 3, but the difference did not reach statistical significance (P > 0.05).
  
  
  CONCLUSIONS
  Adiponectin levels are elevated in line with ADMA and sP-selectin levels. Since CsA induces higher adiponectin levels, platelet activation and endothelial dysfunction. These changes may be responsible for the increased risk of post-transplant cardiovascular events in renal transplant patients.
authors: Nephrology Department, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors: Garip
authors: G
authors: Sahin
authors: Olga Meltem
authors: OM
authors: Akay
authors: Sema
authors: S
authors: Uslu
authors: Cengiz
authors: C
authors: Bal
authors: Ahmet Ugur
authors: AU
authors: Yalcin
authors: Zafer
authors: Z
authors: Gulbas
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D016022:Case-Control Studies; D016572:Cyclosporine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D012307:Risk Factors; D016559:Tacrolimus / Q000008:administration & dosage*; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D007166:Immunosuppressive Agents; D019007:P-Selectin; C546937:SELP protein, human; C018524:N,N-dimethylarginine; D016572:Cyclosporine; D001120:Arginine; D016559:Tacrolimus
keywords: Adiponectin; asymmetric dimethyl arginine; cyclosporine; platelet aggregation; renal transplantation; soluble P selectin; tacrolimus