title: Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.
abstract: Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults-a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.
authors: Division of Endocrinology, Oregon Health and Science University, Portland, OR, USA; Bone and Mineral Unit, Oregon Health and Science University, Portland, OR, USA.
authors: Christine M
authors: CM
authors: Swanson
authors: Steven A
authors: SA
authors: Shea
authors: Katie L
authors: KL
authors: Stone
authors: Jane A
authors: JA
authors: Cauley
authors: Clifford J
authors: CJ
authors: Rosen
authors: Susan
authors: S
authors: Redline
authors: Gerard
authors: G
authors: Karsenty
authors: Eric S
authors: ES
authors: Orwoll
mesh_terms: D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000503:physiopathology*; D016723:Bone Remodeling; D001842:Bone and Bones / Q000503:physiopathology*; D002940:Circadian Rhythm; D006801:Humans; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology*
keywords: BONE MINERAL DENSITY (BMD); BONE REMODELING; CIRCADIAN RHYTHM; FRACTURE; NOCTURNAL HYPOXIA; OBSTRUCTIVE SLEEP APNEA (OSA); REVIEW; SLEEP; SLEEP LOSS
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