title: The metabolic milieu of metastases.
abstract: To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
authors: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors: William J
authors: WJ
authors: Sullivan
authors: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hchristofk@mednet.ucla.edu.
authors: Heather R
authors: HR
authors: Christofk
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D009362:Neoplasm Metastasis / Q000235:genetics*
chemical_list: C000595937:MIRN-551 microRNA, human; C548912:MIRN483 microRNA, human; D035683:MicroRNAs