title: Pixel-by-Pixel Comparison of Volume Transfer Constant and Estimates of Cerebral Blood Volume from Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast-Enhanced MR Imaging in High-Grade Gliomas.
abstract: OBJECTIVE
  Estimates of blood volume and volume transfer constant are parameters commonly used to characterize hemodynamic properties of brain lesions. The purposes of this study were to compare values of volume transfer constant and estimates of blood volume in high-grade gliomas on a pixel-by-pixel basis to comprehend whether they provide different information and to compare estimates of blood volume obtained by dynamic contrast-enhanced MR imaging and dynamic susceptibility contrast-enhanced MR imaging.
  
  
  METHODS
  Thirty-two patients with biopsy-proved grade IV gliomas underwent dynamic contrast-enhanced MR imaging and dynamic susceptibility contrast-enhanced MR imaging, and parametric maps of volume transfer constant, plasma volume, and CBV maps were calculated. The Spearman rank correlation coefficients among matching values of CBV, volume transfer constant, and plasma volume were calculated on a pixel-by-pixel basis. Comparison of median values of normalized CBV and plasma volume was performed.
  
  
  RESULTS
  Weak-but-significant correlation (P < .001) was noted for all comparisons. Spearman rank correlation coefficients were as follows: volume transfer constant versus CBV, ρ = 0.113; volume transfer constant versus plasma volume, ρ = 0.256; CBV versus plasma volume, ρ = 0.382. We found a statistically significant difference (P < .001) for the estimates of blood volume obtained by using dynamic contrast-enhanced MR imaging (mean normalized plasma volume, 13.89 ± 11.25) and dynamic susceptibility contrast-enhanced MR imaging (mean normalized CBV, 4.37 ± 4.04).
  
  
  CONCLUSIONS
  The finding of a very weak correlation between estimates of microvascular density and volume transfer constant suggests that they provide different information. Estimates of blood volume obtained by using dynamic contrast-enhanced MR imaging are significantly higher than those obtained by dynamic susceptibility contrast-enhanced MR imaging in human gliomas, most likely due to the effect of contrast leakage.
authors: From the Department of Radiology, MR Unit (P.A.-L., D.P., C.A., A.R.) paulaalcaideleon@hotmail.com.
authors: P
authors: P
authors: Alcaide-Leon
authors: From the Department of Radiology, MR Unit (P.A.-L., D.P., C.A., A.R.).
authors: D
authors: D
authors: Pareto
authors: Department of Pathology (E.M.-S.), Hospital Vall d'Hebron, Barcelona, Spain.
authors: E
authors: E
authors: Martinez-Saez
authors: From the Department of Radiology, MR Unit (P.A.-L., D.P., C.A., A.R.).
authors: C
authors: C
authors: Auger
authors: Department of Medical Imaging (A.B.), St Michael's Hospital, Toronto, Ontario, Canada.
authors: A
authors: A
authors: Bharatha
authors: From the Department of Radiology, MR Unit (P.A.-L., D.P., C.A., A.R.).
authors: A
authors: A
authors: Rovira
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D005260:Female; D005910:Glioma / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading
chemical_list: D003287:Contrast Media
references: AJNR Am J Neuroradiol. 2004 May;25(5):746-55
references: 15140713
references: AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2455-65
references: 16286385
references: Cancer Res. 2009 Jul 1;69(13):5296-300
references: 19549889
references: AJR Am J Roentgenol. 2013 Jan;200(1):24-34
references: 23255738
references: Neuro Oncol. 2014 Jun;16(6):868-79
references: 24759636
references: Radiology. 2008 Nov;249(2):601-13
references: 18780827
references: Eur J Radiol. 2009 Jun;70(3):465-74
references: 18359598
references: AJNR Am J Neuroradiol. 1996 May;17(5):831-40
references: 8733954
references: Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):876-85
references: 16298499
references: Acta Neuropathol. 2007 Aug;114(2):97-109
references: 17618441
references: Br J Radiol. 2007 Mar;80(951):161-8
references: 17303617
references: Radiology. 2010 Aug;256(2):575-84
references: 20529987
references: Clin Radiol. 2014 Jun;69(6):e264-72
references: 24594379
references: AJNR Am J Neuroradiol. 2006 Apr;27(4):853-8
references: 16611778
references: Radiology. 1994 Apr;191(1):41-51
references: 8134596
references: AJNR Am J Neuroradiol. 2000 May;21(5):901-9
references: 10815666
references: Magn Reson Imaging. 2009 Nov;27(9):1208-15
references: 19559556
references: PLoS One. 2014 Mar 26;9(3):e92910
references: 24670992
references: Semin Oncol. 1986 Mar;13(1):16-26
references: 3006257
references: Med Image Anal. 1996 Mar;1(1):35-51
references: 9873920
references: AJR Am J Roentgenol. 2012 Jan;198(1):19-26
references: 22194475
references: AJNR Am J Neuroradiol. 2006 Apr;27(4):859-67
references: 16611779
references: AJR Am J Roentgenol. 2006 Oct;187(4):1036-42
references: 16985154
references: AJNR Am J Neuroradiol. 2009 Apr;30(4):681-8
references: 19179427
references: AJNR Am J Neuroradiol. 2014 Jun;35(6):1103-10
references: 24384119
references: J Magn Reson Imaging. 1999 Sep;10(3):223-32
references: 10508281