title: Synthesis and characterization of cerium- and gallium-containing borate bioactive glass scaffolds for bone tissue engineering.
abstract: Bioactive glasses are widely used in biomedical applications due to their ability to bond to bone and even to soft tissues. In this study, borate based (13-93B3) bioactive glass powders containing up to 5 wt% Ce2O3 and Ga2O3 were prepared by the melt quench technique. Cerium (Ce+3) and gallium (Ga+3) were chosen because of their low toxicity associated with bacteriostatic properties. Bioactive glass scaffolds were fabricated using the polymer foam replication method. In vitro degradation and bioactivity of the scaffolds were evaluated in SBF under static conditions. Results revealed that the cerium- and gallium-containing borate glasses have much lower degradation rates compared to the bare borate glass 13-93B3. In spite of the increased chemical durability, substituted glasses exhibited a good in vitro bioactive response except when the Ce2O3 content was 5 wt%. Taking into account the high in vitro hydroxyapatite forming ability, borate glass scaffolds containing Ce+3 and Ga+3 therapeutic ions are promising candidates for bone tissue engineering applications.
authors: Department of Materials Science and Engineering, and Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Rolla, MO, USA, aylin.deliormanli@cbu.edu.tr.
authors: Aylin M
authors: AM
authors: Deliormanlı
mesh_terms: D001826:Body Fluids / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis*; D001881:Borates / Q000737:chemistry; D002563:Cerium / Q000737:chemistry*; D017886:Durapatite / Q000138:chemical synthesis; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005708:Gallium / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D006244:Hardness; D008422:Materials Testing; D023822:Tissue Engineering / Q000295:instrumentation; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D001881:Borates; D002563:Cerium; C038863:gallium oxide; C030583:ceric oxide; D017886:Durapatite; D005708:Gallium
references: J R Soc Interface. 2010 Aug 6;7 Suppl 4:S379-91
references: 20484227
references: J Mater Sci Mater Med. 2006 Jul;17(7):583-96
references: 16770542
references: J Biomed Mater Res. 1997 Oct;37(1):114-21
references: 9335356
references: Biomaterials. 2012 Nov;33(31):7746-55
references: 22858004
references: Crit Rev Oncol Hematol. 2002 Jun;42(3):283-96
references: 12050020
references: J Biomed Mater Res A. 2010 Oct;95(1):164-71
references: 20544804
references: Br J Pharmacol. 2010 Apr;159(8):1681-92
references: 20397300
references: J Biomed Mater Res A. 2009 Feb;88(2):392-400
references: 18306284
references: J Biomed Mater Res. 1990 Jun;24(6):721-34
references: 2361964
references: J Chem Phys. 2009 Feb 14;130(6):064708
references: 19222291
references: J Biomed Mater Res. 2001;58(6):720-6
references: 11745526
references: Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1401-6
references: 24364938
references: Biomaterials. 2010 Aug;31(22):5865-74
references: 20434766
references: Acta Biomater. 2013 Jan;9(1):4457-86
references: 22922331
references: J Biomed Mater Res. 1998 Sep 15;41(4):511-8
references: 9697022
references: J Biomed Mater Res. 2001 Mar 5;54(3):454-61
references: 11189054
references: Acta Biomater. 2011 Jun;7(6):2355-73
references: 21421084
references: Acta Biomater. 2013 Nov;9(11):9126-36
references: 23827095
references: J Clin Invest. 1984 May;73(5):1487-90
references: 6715548
references: J Mater Sci Mater Med. 2006 Nov;17(11):989-96
references: 17122909
references: Biochem Biophys Res Commun. 2006 Mar 31;342(1):86-91
references: 16480682
references: Materials (Basel). 2010 Jul 06;3(7):3867-3910
references: 28883315
references: Biomed Res Int. 2014;2014:308306
references: 24719853
references: J Biomed Mater Res A. 2010 Oct;95(1):172-9
references: 20540099
references: J Mater Sci Mater Med. 2013 Mar;24(3):583-95
references: 23233025
references: J R Soc Interface. 2004 Nov 22;1(1):17-22
references: 16849149
references: J R Soc Interface. 2012 Mar 7;9(68):401-19
references: 22158843
references: J Biomater Appl. 2014 Jan;28(5):643-53
references: 23241965
references: Acta Biomater. 2013 Jan;9(1):4836-44
references: 23026489
references: Acta Biomater. 2009 May;5(4):1198-210
references: 18974026