title: Biological effects of low level laser therapy.
abstract: The use of low level laser to reduce pain, inflammation and edema, to promote wound, deeper tissues and nerves healing, and to prevent tissue damage has been known for almost forty years since the invention of lasers. This review will cover some of the proposed cellular mechanisms responsible for the effect of visible light on mammalian cells, including cytochrome c oxidase (with absorption peaks in the Near Infrared (NIR)). Mitochondria are thought to be a likely site for the initial effects of light, leading to increased ATP production, modulation of reactive oxygen species, and induction of transcription factors. These effects in turn lead to increased cell proliferation and migration (particularly by fibroblasts).
authors: Department of Genetics, Faculty of Biological Science, Shahid Beheshti University (GC), Tehran, Iran.
authors: Shirin
authors: S
authors: Farivar
authors: Department of Genetics, Faculty of Biological Science, Shahid Beheshti University (GC), Tehran, Iran.
authors: Talieh
authors: T
authors: Malekshahabi
authors: Departmentof Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Shiari
keywords: cell migration; cell proliferation; cytochrome c oxidase; low level laser therapy; reactive oxygen species
references: Natl J Maxillofac Surg. 2012 Jul;3(2):124-32
references: 23833485
references: J Biol Chem. 2003 Oct 17;278(42):40917-22
references: 12851407
references: Photochem Photobiol. 2002 Aug;76(2):164-70
references: 12194212
references: Free Radic Biol Med. 2012 Sep 15;53(6):1252-63
references: 22841758
references: Biochim Biophys Acta. 2000 Aug 15;1459(2-3):405-12
references: 11004457
references: Photochem Photobiol Sci. 2002 Aug;1(8):547-52
references: 12659495
references: J Transl Med. 2010 Feb 16;8:16
references: 20158898
references: Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14602-7
references: 11121062
references: Photochem Photobiol. 1997 Dec;66(6):866-71
references: 9421973
references: Mol Cell Biol. 2002 Jul;22(13):4587-97
references: 12052868
references: J Invest Dermatol. 2003 May;120(5):849-57
references: 12713592
references: Lasers Surg Med. 1998;22(4):212-8
references: 9603282
references: J Photochem Photobiol B. 1989 Aug;3(4):642-3
references: 2507765
references: Dose Response. 2009 Sep 01;7(4):358-83
references: 20011653
references: Circ Res. 2005 Nov 11;97(10 ):967-74
references: 16284189
references: J Cell Physiol. 2008 Nov;217(2):518-28
references: 18615581
references: FASEB J. 1995 Jun;9(9):718-25
references: 7601336
references: Biochim Biophys Acta. 2001 Mar 1;1504(1):46-57
references: 11239484
references: Cell. 1996 Jun 14;85(6):829-39
references: 8681378
references: J Photochem Photobiol B. 1999 Mar;49(1):1-17
references: 10365442
references: Oncogene. 2002 Mar 27;21(13):1978-88
references: 11960370
references: FEBS Lett. 1994 Jun 6;346(1):39-43
references: 8206156
references: Evid Based Complement Alternat Med. 2013;2013:175629
references: 23737818
references: Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16774-9
references: 15546991
references: Med Oral Patol Oral Cir Bucal. 2013 Jul 01;18(4):e603-12
references: 23722130
references: Dokl Akad Nauk. 1995 Jun;342(5):693-5
references: 7670387
references: J Biol Chem. 2001 Jul 20;276(29):27406-14
references: 11297552
references: Eur J Biochem. 1991 May 8;197(3):563-76
references: 2029890
references: Mol Cell Biol. 2001 Apr;21(8):2933-43
references: 11283270
references: Nature. 2006 Oct 26;443(7114):901-3
references: 17066004
references: Photomed Laser Surg. 2005 Aug;23(4):355-61
references: 16144476
references: Dermatol Surg. 2005 Mar;31(3):334-40
references: 15841638
references: Lasers Surg Med. 2005 Apr;36(4):307-14
references: 15739174
references: PLoS One. 2011;6(7):e22453
references: 21814580
references: Lasers Surg Med. 2005 Aug;37(2):161-71
references: 16037971