title: Dendrimer-entrapped metal colloids as imaging agents.
abstract: This review reports the recent advances in dendrimer-entrapped metal colloids as contrast agents for biomedical imaging applications. The versatile dendrimer scaffolds with 3-dimensional spherical shape, highly branched internal cavity, tunable surface conjugation chemistry, and excellent biocompatibility and nonimmunogenicity afford their uses as templates to create multifunctional dendrimer-entrapped metal colloids for mono- or multi- mode molecular imaging applications. In particular, multifunctional dendrimer-entrapped gold nanoparticles with different surface modifications have been used for fluorescence imaging, targeted tumor computed tomography (CT) imaging, enhanced blood pool CT imaging, dual mode CT/MR imaging, and tumor theranostics (combined CT imaging and chemotherapy) will be introduced and discussed in detail.
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, People's Republic of China.
authors: Du
authors: D
authors: Li
authors: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China.
authors: Shihui
authors: S
authors: Wen
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, People's Republic of China.|College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China.
authors: Xiangyang
authors: X
authors: Shi
mesh_terms: D000818:Animals; D003102:Colloids / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D003952:Diagnostic Imaging; D006801:Humans; D008670:Metals / Q000737:chemistry*; D000068936:Theranostic Nanomedicine; D014057:Tomography, X-Ray Computed
chemical_list: D003102:Colloids; D050091:Dendrimers; D008670:Metals