title: Dissociable attentional and inhibitory networks of dorsal and ventral areas of the right inferior frontal cortex: a combined task-specific and coordinate-based meta-analytic fMRI study.
abstract: The right inferior frontal cortex (rIFC) is frequently activated during executive control tasks. Whereas the function of the dorsal portion of rIFC, more precisely the inferior frontal junction (rIFJ), is convergingly assigned to the attention system, the functional key role of the ventral portion, i.e., the inferior frontal gyrus (rIFG), is hitherto controversially debated. Here, we used a two-step methodical approach to clarify the differential function of rIFJ and rIFG. First, we used event-related functional magnetic resonance imaging (fMRI) during a modified stop signal task with an attentional capture condition (acSST) to delineate attentional from inhibitory motor processes (step 1). Then, we applied coordinate-based meta-analytic connectivity modeling (MACM) to assess functional connectivity profiles of rIFJ and rIFG across various paradigm classes (step 2). As hypothesized, rIFJ activity was associated with the detection of salient stimuli, and was functionally connected to areas of the ventral and dorsal attention network. RIFG was activated during successful response inhibition even when controlling for attentional capture and revealed the highest functional connectivity with core motor areas. Thereby, rIFJ and rIFG delineated largely independent brain networks for attention and motor control. MACM results attributed a more specific attentional function to rIFJ, suggesting an integrative role between stimulus-driven ventral and goal-directed dorsal attention processes. In contrast, rIFG was disclosed as a region of the motor control but not attention system, being essential for response inhibition. The current study provides decisive evidence regarding a more precise functional characterization of rIFC subregions in attention and inhibition.
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
authors: Alexandra
authors: A
authors: Sebastian
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany. patrjung@uni-mainz.de.
authors: Patrick
authors: P
authors: Jung
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
authors: Jonathan
authors: J
authors: Neuhoff
authors: Brain Imaging Center, MEG Unit, Goethe University Frankfurt/Main, Frankfurt/Main, Germany.
authors: Michael
authors: M
authors: Wibral
authors: Research Imaging Institute, University of Texas Health Science Center, San Antonio, USA.|South Texas Veterans Health Care System, San Antonio, USA.
authors: Peter T
authors: PT
authors: Fox
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
authors: Klaus
authors: K
authors: Lieb
authors: Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt/Main, Germany.
authors: Pascal
authors: P
authors: Fries
authors: Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.|Institute for Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.
authors: Simon B
authors: SB
authors: Eickhoff
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.|Departments of Neurology and Psychiatry, Albert-Ludwigs-University Medical Center Freiburg, Freiburg, Germany.
authors: Oliver
authors: O
authors: Tüscher
authors: Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
authors: Arian
authors: A
authors: Mobascher
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D011930:Reaction Time; D055815:Young Adult
keywords: Attentional capture; Functional magnetic resonance imaging; Meta-analytic connectivity modeling; Right inferior frontal cortex; Right inferior frontal junction; Stop signal task
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