title: Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
abstract: BACKGROUND
  Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases.
  
  
  OBJECTIVE
  The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD) and lichen planus (LP) patients in order to evaluate its role in the pathogenesis of both diseases.
  
  
  METHODS
  This study included 15 patients with AD (Group I), 15 patients with LP (Group II), in addition to 10 healthy skin specimens served as controls (Group III). Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression.
  
  
  RESULTS
  Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001].
  
  
  CONCLUSIONS
  Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.
authors: Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
authors: Zeinab A
authors: ZA
authors: Ibrahim
authors: Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
authors: Amal A
authors: AA
authors: El Ashmawy
authors: Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
authors: Naeim M
authors: NM
authors: Abd El-Naby
authors: Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
authors: Hussein M
authors: HM
authors: Ghoraba
keywords: Atopic dermatitis; cathepsin L; lichen planus and proteases
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