title: The analysis of clinico-pathologic characteristics in patients who underwent surgery due to stricturing and non-perineal fistulizing forms of Crohn's disease: a retrospective cohort study.
abstract: BACKGROUND
  The diagnosis of Crohn's disease is based mainly on the patient's history and clinical examination and supported by serologic, radiologic, endoscopic, and histologic findings.
  
  
  OBJECTIVE
  The main purpose of the present study was to evaluate in a retrospective manner the clinico-pathological characteristics of patients who underwent surgery due to stricturing or non perineal fistulizing Crohn's disease.
  
  
  METHODS
  Between January 2007 and June 2012, 75 patients who were operated on for stricturing and non-perineal fistulizing forms of Crohn's disease were analyzed according to their clinico-pathological characteristics.
  
  
  RESULTS
  The L3 localization (Montreal Classification) was detected significantly more often in the non-perineal fistulizing group than in the stricturing group (P < 0.03). Wound infection (18 patient, 24%) was the most commonly observed postoperative complication, followed by postoperative ileus (5 patients, 6.7%) and intraabdominal abscess (4 patients, 5.2%). The distribution of postoperative complications according to the two groups was not significantly different (P = 0.772). Submucosal fibrosis, ulcers and transmural inflammation were the three most common histopathological signs in resected specimens from both groups. Pseudopolyps, microabscess, granuloma, mononuclear inflammation and deep fissures were significantly far more frequent in the non perineal fistulizing group when compared to the stricturing group (P < 0.05). On the other hand, superficial ulcers were significantly more frequent in the stricturing group (P = 0.007).
  
  
  CONCLUSIONS
  No specific clinical feature was found to differentiate patients with the stricturing form of Crohn's disease from the fistulizing form. However, histopathological analysis of the resected specimens revealed significant differences in some parameters between the two disease forms.
authors: Sevket Yilmaz Teaching and Research Hospital, Department of Gastroenterological Surgery, Bursa, Turkey. Electronic address: hmurat.cayci@gmail.com.
authors: Murat
authors: M
authors: Cayci
authors: Sakarya University, Faculty of Medicine, Department of General Surgery, Sakarya, Turkey.
authors: Erdal Birol
authors: EB
authors: Bostanci
authors: Turkiye Yuksek Ihtisas Teaching and Research Hospital, Department of Pathology, Ankara, Turkey.
authors: Nesrin
authors: N
authors: Turhan
authors: Sakarya University, Faculty of Medicine, Department of General Surgery, Sakarya, Turkey.
authors: Kerem
authors: K
authors: Karaman
authors: Turkiye Yuksek Ihtisas Teaching and Research Hospital, Department of Gastroenterological Surgery, Ankara, Turkey.
authors: Tahsin
authors: T
authors: Dalgic
authors: Turkiye Yuksek Ihtisas Teaching and Research Hospital, Department of Gastroenterological Surgery, Ankara, Turkey.
authors: Ilter
authors: I
authors: Ozer
authors: Sakarya University, Faculty of Medicine, Department of General Surgery, Sakarya, Turkey.
authors: Metin
authors: M
authors: Ercan
authors: Turkiye Yuksek Ihtisas Teaching and Research Hospital, Department of Gastroenterological Surgery, Ankara, Turkey.
authors: Murat
authors: M
authors: Ulas
authors: Sakarya University, Faculty of Medicine, Department of General Surgery, Sakarya, Turkey.
authors: Musa
authors: M
authors: Akoglu
mesh_terms: D000328:Adult; D003251:Constriction, Pathologic / Q000209:etiology / Q000473:pathology / Q000601:surgery; D003424:Crohn Disease / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: Crohn's disease; Fistula; Ilececal resection; Perianal; Stricture