title: New Lignans and Iridoid Glycosides from Dipsacus asper Wall.
abstract: Six new compounds, including four new lignans, dipsalignan A (1), B-D (3-5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities.
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. sxgzhwu07@163.com.
authors: Xinguang
authors: X
authors: Sun
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. mgxfl8785@163.com.
authors: Guoxu
authors: G
authors: Ma
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. zhangdw517@gmail.com.
authors: Dawei
authors: D
authors: Zhang
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. whhuang@implad.ac.cn.
authors: Wenhua
authors: W
authors: Huang
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. dgfyhchina@163.com.
authors: Gang
authors: G
authors: Ding
authors: State Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine, MINZU University of China, Beijing 10081, China. tangang_666@163.com.
authors: Huagang
authors: H
authors: Hu
authors: Beijing Institute of Microchemistry, Beijing 100091, China. tgz2008@microchem.org.cn.
authors: Guangzhong
authors: G
authors: Tu
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. guobaolin010@163.com.
authors: Baolin
authors: B
authors: Guo
mesh_terms: D002473:Cell Wall / Q000737:chemistry; D049917:Dipsacaceae / Q000737:chemistry* / Q000166:cytology; D019427:HIV Integrase / Q000737:chemistry; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015497:HIV-1 / Q000201:enzymology; D057889:Iridoid Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry* / Q000166:cytology
chemical_list: D019428:HIV Integrase Inhibitors; D057889:Iridoid Glycosides; D017705:Lignans; D019427:HIV Integrase
references: Planta Med. 2012 Mar;78(5):480-4
references: 22281716
references: Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1677-81
references: 18057739
references: J Nat Prod. 2002 Oct;65(10):1479-85
references: 12398547
references: J Ethnopharmacol. 2009 May 4;123(1):74-81
references: 19429343
references: J Ethnopharmacol. 2012 Jan 6;139(1):98-103
references: 22041103
references: Fitoterapia. 2001 Jan;72(1):80-2
references: 11163950
references: J Nat Prod. 2014 Mar 28;77(3):663-7
references: 24404757
references: Planta Med. 2004 Jun;70(6):509-14
references: 15229801
references: J Ethnopharmacol. 2006 Nov 24;108(2):188-92
references: 16809011
references: Chem Pharm Bull (Tokyo). 1966 Jun;14(6):641-7
references: 5964630
references: J Asian Nat Prod Res. 2011 Sep;13(9):851-60
references: 21830891
references: Planta Med. 2013 Oct;79(15):1470-3
references: 24046216
references: Planta Med. 1997 Oct;63(5):393-9
references: 9342940
references: Acta Pharmacol Sin. 2008 Mar;29(3):397-404
references: 18298906
references: Phytochemistry. 2010 Jan;71(1):90-4
references: 19863977