title: Ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases.
abstract: Multiple factors have been shown to alter intestinal microbial diversity. It remains to be seen, however, how multiple collective pressures impact the activity in the gut environment and which, if any, is positioned as a dominant driving factor determining the final metabolic outcomes. Here, we describe the results of a metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus (SLE) and 17 healthy control subjects and demonstrate a statistically significant difference (p < 0.05) between the two groups. Healthy controls could be categorized (p < 0.05) based on their body mass index (BMI), whereas individuals with SLE could not. We discuss the prevalence of SLE compared with BMI as the dominant factor that regulates gastrointestinal microbial metabolism and provide plausible explanatory causes. Our results uncover novel perspectives with clinical relevance for human biology. In particular, we rank the importance of various pathophysiologies for gut homeostasis.
authors: Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid.
authors: David
authors: D
authors: Rojo
authors: Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute (IPLA), Consejo Superior de Investigaciones Científicas (CSIC), Villaviciosa, Asturias, Spain.
authors: Arancha
authors: A
authors: Hevia
authors: Institute of Catalysis, CSIC, Madrid, Spain.
authors: Rafael
authors: R
authors: Bargiela
authors: Immunology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain.
authors: Patricia
authors: P
authors: López
authors: Physiology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain.
authors: Adriana
authors: A
authors: Cuervo
authors: Physiology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain.
authors: Sonia
authors: S
authors: González
authors: Immunology Area, Department of Functional Biology, University of Oviedo, Asturias, Spain.
authors: Ana
authors: A
authors: Suárez
authors: Institute of Catalysis, CSIC, Madrid, Spain.
authors: Borja
authors: B
authors: Sánchez
authors: Institute of Catalysis, CSIC, Madrid, Spain.
authors: Mónica
authors: M
authors: Martínez-Martínez
authors: Department of Life Sciences, Laboratory of Probiogenomics, University of Parma, Parma, Italy.
authors: Christian
authors: C
authors: Milani
authors: Department of Life Sciences, Laboratory of Probiogenomics, University of Parma, Parma, Italy.
authors: Marco
authors: M
authors: Ventura
authors: Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid.
authors: Coral
authors: C
authors: Barbas
authors: 1] Unidad Mixta de Investigación en Genómica y Salud de la Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) and Instituto Cavanilles de Biodiversidad y Biología Evolutiva de la Universitat de València, València, Spain [2] CIBER en Epidemiología y Salud Pública (CIBEResp), Madrid, Spain.
authors: Andrés
authors: A
authors: Moya
authors: Department of Biochemistry and Molecular Biology, Biomedical Research Centre, University of Granada, Granada, Spain.
authors: Antonio
authors: A
authors: Suárez
authors: Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute (IPLA), Consejo Superior de Investigaciones Científicas (CSIC), Villaviciosa, Asturias, Spain.
authors: Abelardo
authors: A
authors: Margolles
authors: Institute of Catalysis, CSIC, Madrid, Spain.
authors: Manuel
authors: M
authors: Ferrer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000382:microbiology; D006706:Homeostasis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D055432:Metabolomics; D064307:Microbiota; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*
chemical_list: D019158:N-Acetylneuraminic Acid
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