title: HEpD: a database describing epigenetic differences between Thoroughbred and Jeju horses.
abstract: With the advent of next-generation sequencing technology, genome-wide maps of DNA methylation are now available. The Thoroughbred horse is bred for racing, while the Jeju horse is a traditional Korean horse bred for racing or food. The methylation profiles of equine organs may provide genomic clues underlying their athletic traits. We have developed a database to elucidate genome-wide DNA methylation patterns of the cerebrum, lung, heart, and skeletal muscle from Thoroughbred and Jeju horses. Using MeDIP-Seq, our database provides information regarding significantly enriched methylated regions beyond a threshold, methylation density of a specific region, and differentially methylated regions (DMRs) for tissues from two equine breeds. It provided methylation patterns at 784 gene regions in the equine genome. This database can potentially help researchers identify DMRs in the tissues of these horse species and investigate the differences between the Thoroughbred and Jeju horse breeds.
authors: Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea; Genetic Engineering Institute, Pusan National University, Busan 609-735, Republic of Korea.
authors: Jeong-An
authors: JA
authors: Gim
authors: Department of Statistics, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.
authors: Sugi
authors: S
authors: Lee
authors: Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.
authors: Dae-Soo
authors: DS
authors: Kim
authors: Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea; Institute of Environmental Technology & Industry, Pusan National University, Busan 609-735, Republic of Korea.
authors: Kwang-Seuk
authors: KS
authors: Jeong
authors: TBI, Theragen BiO Institute, TheragenEtex, Suwon 443-270, Republic of Korea.
authors: Chang Pyo
authors: CP
authors: Hong
authors: Research Center, Dongnam Institute of Radiological and Medical Sciences (DIRAMS), Busan, Republic of Korea.
authors: Jin-Han
authors: JH
authors: Bae
authors: TBI, Theragen BiO Institute, TheragenEtex, Suwon 443-270, Republic of Korea.
authors: Jae-Woo
authors: JW
authors: Moon
authors: Genetic Engineering Institute, Pusan National University, Busan 609-735, Republic of Korea; Department of Statistics, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.
authors: Yong-Seok
authors: YS
authors: Choi
authors: Department of Animal Science, College of Life Sciences, Pusan National University, Miryang 627-702, Republic of Korea.
authors: Byung-Wook
authors: BW
authors: Cho
authors: School of Computer Science and Engineering, College of Engineering, Pusan National University, Busan 609-735, Republic of Korea.
authors: Hwan-Gue
authors: HG
authors: Cho
authors: TBI, Theragen BiO Institute, TheragenEtex, Suwon 443-270, Republic of Korea; BioMedical Engineering, UNIST, Ulsan, Republic of Korea.
authors: Jong
authors: J
authors: Bhak
authors: Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea; Genetic Engineering Institute, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: khs307@pusan.ac.kr.
authors: Heui-Soo
authors: HS
authors: Kim
mesh_terms: D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping / Q000662:veterinary; D018899:CpG Islands; D019175:DNA Methylation; D030541:Databases, Genetic; D044127:Epigenesis, Genetic; D059014:High-Throughput Nucleotide Sequencing / Q000662:veterinary; D006736:Horses / Q000235:genetics*; D008168:Lung / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism
keywords: DNA methylation; Differentially methylated region; Jeju horse; MeDIP-Seq; Thoroughbred horse