title: Acyclic L-threoninol nucleic acid (L-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA.
abstract: We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.
authors: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. kashida@nubio.nagoya-u.ac.jp asanuma@nubio.nagoya-u.ac.jp.
authors: Keiji
authors: K
authors: Murayama
authors: Hiromu
authors: H
authors: Kashida
authors: Hiroyuki
authors: H
authors: Asanuma
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001483:Base Sequence; D002072:Butylene Glycols / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000737:chemistry* / Q000235:genetics
chemical_list: D000605:Amino Alcohols; D002072:Butylene Glycols; C532652:threoninol; D012313:RNA; D004247:DNA