title: Post-irradiation otitis media, rhinosinusitis, and their interrelationship in nasopharyngeal carcinoma patients treated by IMRT.
abstract: This study aimed to investigate the occurrences of post-irradiation chronic suppurative otitis media (CSOM), otitis media with effusion (OME), chronic rhinosinusitis (CRS), and their interrelationship in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT). A retrospective review of medical records and magnetic resonance imaging for NPC patients across a 5-year follow-up was conducted. Rhinosinusitis was diagnosed and staged by Lund-Mackay system. A total of 102 patients were enrolled in the study. On the 5th year following IMRT, 8 patients (7.8 %), 30 patients (29.4 %), and 17 patients (16.7 %) suffered from IMRT-induced CSOM, post-irradiation OME, and CRS, respectively. Analysis by logistic regression showed a lack of association between the occurrence of post-irradiation OME and CRS (P = 0.06). These observations indicated that the modern radiotherapy technique exhibits capability in decreasing the incidences of CSOM and CRS comparing to the data of traditional radiotherapy. But post-irradiation OME was still encountered in more than one-quarter of long-term survivors of NPC. Of note, rhinosinusitis in NPC survivors does not predispose to the development of post-irradiation OME, suggesting nasal irrigation might be unnecessary for the management of OME following radiotherapy.
authors: Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Chung-Han
authors: CH
authors: Hsin
authors: School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Hsien-Chun
authors: HC
authors: Tseng
authors: Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Huang-Pin
authors: HP
authors: Lin
authors: School of Medicine, Chung Shan Medical University, Taichung, Taiwan. cth.ntu@gmail.com.|Department of Anesthesiology, Cheng Ching General Hospital, No. 966, Sec. 4, Taiwan Boulevard, Taichung, 40764, Taiwan. cth.ntu@gmail.com.
authors: Tsai-Hsin
authors: TH
authors: Chen
mesh_terms: D000369:Aged, 80 and over; D002277:Carcinoma; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D010033:Otitis Media / Q000175:diagnosis / Q000209:etiology*; D011832:Radiation Injuries / Q000150:complications* / Q000175:diagnosis; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D012189:Retrospective Studies; D012852:Sinusitis / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D055815:Young Adult
keywords: Complication; Intensity-modulated radiotherapy; Nasopharyngeal carcinoma; Otitis media; Rhinosinusitis
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