title: Complications of injected vitamin E as a filler for lip augmentation: case series and therapeutic approach.
abstract: The strive for proficient cosmetic facial appearance is growing in the past decades. Fillers for tissue augmentation are gaining wide popularity. Uncertified products based on oleic solutions are applied by untrained staff, thus growing the risk for certain complications such as infections, allergic and irritant contact dermatitis, and lipogranuloma formation. We present a series of three cases lipogranuloma after liquid vitamin E injection for lip augmentation. In all cases, painful edema at the injected area followed the procedure. The patients were presented with erythema, firm indurations of the lips and the perioral skin, and tenderness. Histological examination of skin biopsies showed round-ovoid cavities of varying sizes, resulting in a Swiss cheese-like appearance, consistent with a lipogranuloma. In this paper, we propose a protocol for treatment of this specific complication with systemic corticosteroids and a broad spectrum antibiotics.
authors: Department of Dermatology and Venereology, Medical Faculty-Sofia, Sofia, Bulgaria.
authors: Ban
authors: B
authors: Kamouna
authors: Razvigor
authors: R
authors: Darlenski
authors: Jana
authors: J
authors: Kazandjieva
authors: Maria
authors: M
authors: Balabanova
authors: Lubomir
authors: L
authors: Dourmishev
authors: Zorka
authors: Z
authors: Negentsova
authors: Doncho
authors: D
authors: Etugov
authors: Biljana
authors: B
authors: Mirchevska
authors: Nikolai
authors: N
authors: Tsankov
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D003357:Cosmetic Techniques / Q000009:adverse effects*; D000067548:Dermal Fillers / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007279:Injections, Subcutaneous; D008047:Lip Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D012060:Rejuvenation; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000067548:Dermal Fillers; D014810:Vitamin E
keywords: adverse effect; aesthetic; filler; injection; lip augmentation; lipogranuloma; vitamin E