title: Recurrence rates and clinical outcome for dogs with grade II mast cell tumours with a low AgNOR count and Ki67 index treated with surgery alone.
abstract: Grade II mast cell tumours (MCT) are tumours with variable biologic behaviour. Multiple factors have been associated with outcome, including proliferation markers. The purpose of this study was to determine if extent of surgical excision affects recurrence rate in dogs with grade II MCT with low proliferation activity, determined by Ki67 and argyrophilic nucleolar organising regions (AgNOR). Eighty-six dogs with cutaneous MCT were evaluated. All dogs had surgical excision of their MCT with a low Ki67 index and combined AgNORxKi67 (Ag67) values. Twenty-three (27%) dogs developed local or distant recurrence during the median follow-up time. Of these dogs, six (7%) had local recurrence, one had complete and five had incomplete histologic margins. This difference in recurrence rates between dogs with complete and incomplete histologic margins was not significant. On the basis of this study, ancillary therapy may not be necessary for patients with incompletely excised grade II MCT with low proliferation activity.
authors: Department of Medical Oncology, Chicago Veterinary Cancer Center, Chicago, IL, USA.
authors: J
authors: J
authors: Smith
authors: Diagnostic Center for Population and Animal Health, Michigan State University, East Lansing, MI, USA.
authors: M
authors: M
authors: Kiupel
authors: Department of Medical Oncology, The Veterinary Cancer Center, Norwalk, CT, USA.
authors: J
authors: J
authors: Farrelly
authors: Department of Science Research, Cornell University, Ithaca, NY, USA.
authors: R
authors: R
authors: Cohen
authors: Department of Medical Oncology, The Veterinary Cancer Center, Norwalk, CT, USA.
authors: G
authors: G
authors: Olmsted
authors: Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands.
authors: J
authors: J
authors: Kirpensteijn
authors: Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands.
authors: B
authors: B
authors: Brocks
authors: Department of Medical Oncology, The Veterinary Cancer Center, Norwalk, CT, USA.
authors: G
authors: G
authors: Post
mesh_terms: D000818:Animals; D034961:Antigens, Nuclear / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D004283:Dog Diseases / Q000453:epidemiology / Q000378:metabolism* / Q000601:surgery; D004285:Dogs; D005260:Female; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D034701:Mastocytosis, Cutaneous / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C051963:nucleolar organizer region associated proteins
keywords: Ag67; AgNOR; Ki67; mast cell tumours