title: The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis.
abstract: Plant hormones are transported across cell membranes during various physiological events. Recent identification of abscisic acid and strigolactone transporters suggests that transport of various plant hormones across membranes does not occur by simple diffusion but requires transporter proteins that are strictly regulated during development. Here, we report that a major glucosinolate transporter, GTR1/NPF2.10, is multifunctional and may be involved in hormone transport in Arabidopsis thaliana. When heterologously expressed in oocytes, GTR1 transports jasmonoyl-isoleucine and gibberellin in addition to glucosinolates. gtr1 mutants are severely impaired in filament elongation and anther dehiscence resulting in reduced fertility, but these phenotypes can be rescued by gibberellin treatment. These results suggest that GTR1 may be a multifunctional transporter for the structurally distinct compounds glucosinolates, jasmonoyl-isoleucine and gibberellin, and may positively regulate stamen development by mediating gibberellin supply.
authors: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan.
authors: Hikaru
authors: H
authors: Saito
authors: Graduate School of Science, Tohoku University, 6-3, Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-0845, Japan.
authors: Takaya
authors: T
authors: Oikawa
authors: Graduate School of Engineering, Tohoku University, 6-6-07, Aobayama, Aoba-ku, Sendai 980-8579, Japan.
authors: Shin
authors: S
authors: Hamamoto
authors: Graduate School of Science, Tohoku University, 6-3, Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-0845, Japan.
authors: Yasuhiro
authors: Y
authors: Ishimaru
authors: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan.
authors: Miyu
authors: M
authors: Kanamori-Sato
authors: Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
authors: Yuko
authors: Y
authors: Sasaki-Sekimoto
authors: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan.
authors: Tomoya
authors: T
authors: Utsumi
authors: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan.
authors: Jing
authors: J
authors: Chen
authors: RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama 230-0045, Japan.
authors: Yuri
authors: Y
authors: Kanno
authors: 1] Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan [2] Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan.
authors: Shinji
authors: S
authors: Masuda
authors: RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama 230-0045, Japan.
authors: Yuji
authors: Y
authors: Kamiya
authors: RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama 230-0045, Japan.
authors: Mitsunori
authors: M
authors: Seo
authors: Graduate School of Engineering, Tohoku University, 6-6-07, Aobayama, Aoba-ku, Sendai 980-8579, Japan.
authors: Nobuyuki
authors: N
authors: Uozumi
authors: Graduate School of Science, Tohoku University, 6-3, Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-0845, Japan.
authors: Minoru
authors: M
authors: Ueda
authors: 1] Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B65 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan [2] Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
authors: Hiroyuki
authors: H
authors: Ohta
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D003517:Cyclopentanes / Q000378:metabolism*; D035264:Flowers / Q000254:growth & development / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant / Q000235:genetics / Q000502:physiology; D005875:Gibberellins / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism*; D054883:Oxylipins / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D003517:Cyclopentanes; C575185:GTR1 protein, Arabidopsis; D005875:Gibberellins; D009004:Monosaccharide Transport Proteins; D054883:Oxylipins; C011006:jasmonic acid
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