title: The prevalence of pseudoxanthoma elasticum-like connective tissue changes in an oral biopsy service and review of the literature.
abstract: OBJECTIVE
  The objective of this pilot study is to determine the prevalence of pseudoxanthoma elasticum (PXE)-like connective changes in an oral biopsy service and compare it with the estimated prevalence of PXE as well as to the prevalence of the mutated PXE gene ABCC6.
  
  
  METHODS
  This prevalence study utilized 500 oral mucosal biopsy specimens received from the biopsy service of the Oral Pathology Consultants at the Ohio State University. Each specimen was microscopically evaluated using hematoxylin and eosin, Verhoeff-van Gieson and von Kossa stains.
  
  
  RESULTS
  A prevalence of 9.8% was identified for PXE-like changes in the connective tissue of oral biopsy specimens submitted to this service.
  
  
  CONCLUSIONS
  The overall prevalence of PXE-like connective tissue changes found in routine oral mucosal biopsy specimens (9.8%) was much higher than either the suspected prevalence of PXE (0.001%-0.004%) or the estimated prevalence of the mutated gene ABCC6 (0.625%-1.25%).
authors: Clinical Assistant Professor, Ohio State University, College of Dentistry, Columbus, OH, USA. Electronic address: harrington.162@osu.edu.
authors: Christine
authors: C
authors: Harrington
authors: Associate Professor Emeritus, Biological Sciences, Ohio State University, College of Dentistry, Columbus, OH, USA.
authors: F Michael
authors: FM
authors: Beck
authors: Professor Emeritus, Division of Oral and Maxillofacial Pathology and Radiology, Ohio State University, College of Dentistry, Columbus, OH, USA.
authors: Carl M
authors: CM
authors: Allen
authors: Clinical Professor, Division of Oral and Maxillofacial Pathology and Radiology, Ohio State University, College of Dentistry, Columbus, OH, USA.
authors: John R
authors: JR
authors: Kalmar
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D011561:Pseudoxanthoma Elasticum / Q000453:epidemiology* / Q000473:pathology