title: Protective Effects of Arachidonic Acid Against Paraquat-Induced Pulmonary Injury.
abstract: In this study, we aimed to study the effects of arachidonic acid (AA) on acute lung injury (ALI) caused by paraquat (PQ) in mice. Male Kunming mice were randomly divided into three groups: control group, PQ group, and PQ + AA group (n = 24). The mice in the PQ and PQ + AA groups received a single oral dose of 20 mg/kg bodyweight PQ, and the mice of the PQ + AA group were challenged by 500 mg/kg bodyweight AA posttreatment 2 h after PQ administration. The results indicated that the administration of AA significantly increased the activity of superoxide dismutase (SOD), decreased the activity of myeloperoxidase (MPO), the content of malondialdehyde (MDA), and the level of lactate dehydrogenase (LDH). Pathological examination also revealed that AA effectively alleviated PQ-induced histological damage. Furthermore, AA significantly reduced PQ-induced upregulations of inflammatory mediators such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8. These results demonstrated that AA had effective protection against PQ-induced ALI.
authors: Pulmonary Department, Affiliated Hospital of QingDao University, Qingdao, 266003, People's Republic China.
authors: Jianxin
authors: J
authors: Du
authors: Xia
authors: X
authors: Li
authors: CunZhi
authors: C
authors: Lin
authors: Xigang
authors: X
authors: He
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010269:Paraquat / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D020011:Protective Agents; D016718:Arachidonic Acid; D010269:Paraquat
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