title: The Intricate Interplay between Mechanisms Underlying Aging and Cancer.
abstract: Age is the major risk factor in the incidence of cancer, a hyperplastic disease associated with aging. Here, we discuss the complex interplay between mechanisms underlying aging and cancer as a reciprocal relationship. This relationship progresses with organismal age, follows the history of cell proliferation and senescence, is driven by common or antagonistic causes underlying aging and cancer in an age-dependent fashion, and is maintained via age-related convergent and divergent mechanisms. We summarize our knowledge of these mechanisms, outline the most important unanswered questions and suggest directions for future research.
authors: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors: Amanda
authors: A
authors: Piano
authors: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors: Vladimir I
authors: VI
authors: Titorenko
keywords: aging; cancer; cell cycle; cell death; cellular senescence; cellular signaling
references: Cell Death Differ. 2007 May;14(5):1020-8
references: 17290286
references: Science. 2009 Jul 10;325(5937):201-4
references: 19590001
references: Mol Cell Biol. 1996 Sep;16(9):5210-8
references: 8756678
references: Aging (Albany NY). 2011 Nov;3(11):1063-77
references: 22170748
references: Mol Pharmacol. 2006 Aug;70(2):510-7
references: 16682503
references: Antioxid Redox Signal. 2012 Jun 1;16(11):1264-84
references: 21883043
references: Oncogene. 2008 Oct 9;27(46):5975-87
references: 18711403
references: Aging (Albany NY). 2011 Oct;3(10):913-9
references: 21990145
references: Cell Metab. 2013 Dec 3;18(6):792-801
references: 24055102
references: J Cell Sci. 2005 Feb 1;118(Pt 3):485-96
references: 15657080
references: Cell Cycle. 2012 Jan 15;11(2):253-63
references: 22234241
references: Mol Cell. 2004 May 21;14(4):501-13
references: 15149599
references: Nat Cell Biol. 2003 Aug;5(8):741-7
references: 12855956
references: J Cell Biol. 2011 Apr 18;193(2):409-24
references: 21502362
references: Mech Ageing Dev. 2005 Jun-Jul;126(6-7):813-21
references: 15888336
references: Histochem Cell Biol. 2001 Oct;116(4):321-7
references: 11702190
references: Aging (Albany NY). 2010 Jun;2(6):333-43
references: 20606251
references: Genes Dev. 1994 Nov 1;8(21):2540-51
references: 7958916
references: Nat Biotechnol. 2012 Jul 10;30(7):671-8
references: 22781696
references: Annu Rev Pathol. 2010;5:99-118
references: 20078217
references: Aging (Albany NY). 2011 Oct;3(10):943-54
references: 22067432
references: Curr Opin Genet Dev. 2013 Feb;23(1):53-62
references: 23317514
references: Clin Cancer Res. 2002 Apr;8(4):1223-7
references: 11948136
references: Nat Rev Cancer. 2008 Jul;8(7):512-22
references: 18574463
references: FEBS Lett. 2006 Nov 13;580(26):6093-9
references: 17056041
references: J Cell Mol Med. 2010 Nov;14(11):2633-40
references: 21114763
references: Cold Spring Harb Symp Quant Biol. 2008;73:513-22
references: 19150958
references: Cell Cycle. 2011 Aug 1;10(15):2440-9
references: 21734470
references: Cancer Res. 2004 May 1;64(9):3215-22
references: 15126362
references: Aging (Albany NY). 2012 Dec;4(12):861-77
references: 23425777
references: J Cell Biol. 2011 Feb 21;192(4):547-56
references: 21321098
references: Cell. 2012 Apr 13;149(2):274-93
references: 22500797
references: Curr Opin Genet Dev. 2011 Feb;21(1):107-12
references: 21093253
references: Nature. 2006 Nov 30;444(7119):638-42
references: 17136094
references: Oncogene. 2001 Oct 29;20(49):7250-6
references: 11704853
references: Nat Rev Drug Discov. 2013 Dec;12(12):931-47
references: 24287781
references: Aging (Albany NY). 2011 Jun;3(6):643-56
references: 21765201
references: Nature. 2007 Aug 16;448(7155):767-74
references: 17700693
references: Biochem J. 2000 Apr 15;347(Pt 2):543-51
references: 10749685
references: Blood. 2000 Dec 15;96(13):4039-45
references: 11110671
references: Cell. 2013 Jun 6;153(6):1194-217
references: 23746838
references: Aging (Albany NY). 2010 Sep;2(9):535-7
references: 20876940
references: Exp Cell Res. 1984 Sep;154(1):191-202
references: 6540707
references: Cell. 2011 Mar 4;144(5):646-74
references: 21376230
references: Mol Cell. 2010 Oct 22;40(2):280-93
references: 20965422
references: Oncogene. 2002 Sep 12;21(41):6328-39
references: 12214273
references: Cell Mol Life Sci. 2009 Aug;66(15):2503-24
references: 19421842
references: Trends Biochem Sci. 2012 Jan;37(1):15-22
references: 22079189
references: Curr Opin Genet Dev. 2010 Jun;20(3):324-9
references: 20304625
references: Cell. 1997 Mar 7;88(5):593-602
references: 9054499
references: Cancer Res. 2001 Mar 1;61(5):2207-11
references: 11280788
references: Nature. 2012 Nov 15;491(7424):364-73
references: 23151579
references: Cancer Res. 2006 Jan 15;66(2):794-802
references: 16424011
references: Mech Ageing Dev. 1976 May-Jun;5(3):193-207
references: 940361
references: Cancer Metastasis Rev. 2006 Sep;25(3):387-408
references: 17043764
references: Cell Death Dis. 2012 Jan 12;3:e248
references: 22237205
references: Aging (Albany NY). 2009 May 07;1(5):490-502
references: 20157532
references: Nature. 2005 Aug 4;436(7051):720-4
references: 16079850
references: Aging (Albany NY). 2010 Nov;2(11):760-74
references: 21084729
references: Nature. 2011 Nov 02;479(7372):232-6
references: 22048312
references: Aging (Albany NY). 2009 May 06;1(5):438-41
references: 20157527
references: Cell. 2008 Jan 11;132(1):27-42
references: 18191218
references: Mol Cell Biol. 2007 Mar;27(6):2343-58
references: 17242207
references: Exp Gerontol. 2004 Nov-Dec;39(11-12):1713-21
references: 15582287
references: J Cell Physiol. 2006 Dec;209(3):617-24
references: 17001697
references: Semin Cancer Biol. 2011 Dec;21(6):397-404
references: 21945348
references: Curr Pharm Des. 2010;16(6):734-40
references: 20388083
references: Mol Cell Biol. 2009 Aug;29(16):4495-507
references: 19528227
references: Biochim Biophys Acta. 2012 Mar;1819(3-4):322-31
references: 21839870
references: Aging (Albany NY). 2011 Feb;3(2):94-101
references: 21297220
references: Cancer Biol Ther. 2011 Jan 15;11(2):157-68
references: 21228626
references: Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1590-3
references: 10359342
references: Cell Cycle. 2008 Nov 1;7(21):3355-61
references: 18948731
references: Oncogene. 2002 Apr 4;21(15):2309-19
references: 11948414
references: Kidney Int. 2003 Jun;63(6):2134-43
references: 12753300
references: Cell Cycle. 2009 Dec 15;8(24):4055-9
references: 19923900
references: Cancer Cell. 2012 Mar 20;21(3):297-308
references: 22439925
references: Mol Cell. 2007 Jul 20;27(2):183-196
references: 17643369
references: Rejuvenation Res. 2008 Jun;11(3):681-3
references: 18593286
references: Cell Cycle. 2012 Jul 1;11(13):2545-56
references: 22722266
references: Cell Metab. 2008 Jan;7(1):11-20
references: 18177721
references: Trends Genet. 2012 Mar;28(3):128-36
references: 22265392
references: Aging (Albany NY). 2010 Jul;2(7):380-2
references: 20657036
references: BMC Biol. 2013 Apr 15;11:36
references: 23587167
references: Cell. 2005 Feb 25;120(4):513-22
references: 15734683
references: Semin Cancer Biol. 2011 Dec;21(6):354-9
references: 21925603
references: Cell Cycle. 2003 Nov-Dec;2(6):517-20
references: 14504464
references: PLoS Biol. 2007 May;5(5):e110
references: 17472436
references: Trends Biochem Sci. 2012 Aug;37(8):317-24
references: 22626470
references: Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):
references: 21917992
references: Cancer Biol Ther. 2013 Dec;14(12):1092-7
references: 24345884
references: Nat Rev Mol Cell Biol. 2012 Jan 23;13(2):103-14
references: 22266760
references: Histochem Cell Biol. 2005 Mar;123(3):263-73
references: 15742196
references: Aging (Albany NY). 2010 Jul;2(7):445-52
references: 20622265
references: Nat Cell Biol. 2006 Nov;8(11):1291-7
references: 17028578
references: J Immunol. 2001 Jun 15;166(12):7571-8
references: 11390513
references: Nature. 2011 Jan 6;469(7328):102-6
references: 21113150
references: Nat Cell Biol. 2010 Jul;12(7):676-85
references: 20526329
references: Int J Mol Sci. 2009 Apr 15;10(4):1609-1627
references: 19468329
references: Cell. 2005 Feb 25;120(4):497-512
references: 15734682
references: Aging (Albany NY). 2010 Jul;2(7):377-9
references: 20657035
references: Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1248-53
references: 17227869
references: Nat Rev Cancer. 2009 Feb;9(2):81-94
references: 19132009
references: Nat Rev Drug Discov. 2013 Nov;12(11):829-46
references: 24113830
references: Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1119-29
references: 18203850
references: Aging (Albany NY). 2010 Sep;2(9):627-31
references: 20930261
references: Cell. 2006 Aug 11;126(3):503-14
references: 16901784
references: Oncogene. 2008 Sep 18;27(42):5643-7
references: 18504431
references: Gene. 2007 Aug 1;397(1-2):84-93
references: 17544228
references: Aging (Albany NY). 2011 Feb;3(2):77-8
references: 21304181
references: Cancer Res. 2007 Apr 1;67(7):3117-26
references: 17409418
references: J Gerontol A Biol Sci Med Sci. 2006 Aug;61(8):763-72
references: 16912092
references: Ageing Res Rev. 2011 Jan;10(1):146-52
references: 20946972
references: Nat Cell Biol. 2004 Mar;6(3):215-26
references: 15039780
references: Dev Cell. 2005 Jan;8(1):19-30
references: 15621527
references: Apoptosis. 2009 Apr;14(4):392-408
references: 19169823
references: J Cell Physiol. 2006 Dec;209(3):592-7
references: 17001692
references: Carcinogenesis. 2010 Jan;31(1):83-9
references: 19969554
references: PLoS Biol. 2008 Dec 2;6(12):2853-68
references: 19053174
references: Biochim Biophys Acta. 2009 Apr;1792(4):341-52
references: 19419692
references: Aging (Albany NY). 2011 Jul;3(7):665-71
references: 21765199
references: Aging (Albany NY). 2011 Mar;3(3):192-222
references: 21422497
references: Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40
references: 17667954
references: Mech Ageing Dev. 2004 Oct-Nov;125(10-11):777-83
references: 15541772
references: Science. 2009 May 22;324(5930):1029-33
references: 19460998
references: Curr Opin Genet Dev. 2011 Feb;21(1):100-6
references: 21087854
references: Aging (Albany NY). 2009 Apr;1(4):402-11
references: 20148189
references: Cell. 1996 Apr 5;85(1):27-37
references: 8620534
references: Ann N Y Acad Sci. 2007 Oct;1114:69-78
references: 17934054
references: Cancer Res. 1995 Jun 1;55(11):2284-92
references: 7757977
references: Aging Cell. 2006 Apr;5(2):187-95
references: 16626397
references: Oncotarget. 2011 Mar;2(3):135-64
references: 21411864
references: EMBO J. 2009 Apr 8;28(7):889-901
references: 19229298
references: Semin Cancer Biol. 2000 Jun;10(3):161-71
references: 10936066
references: Exp Cell Res. 2012 Jan 15;318(2):95-102
references: 22036649
references: Aging (Albany NY). 2010 Dec;2(12):924-35
references: 21212465
references: Exp Cell Res. 1992 Aug;201(2):373-9
references: 1322316
references: Cell Cycle. 2006 Sep;5(18):2087-102
references: 17012837
references: Mech Ageing Dev. 2007 Jan;128(1):36-44
references: 17116315
references: Nat Rev Cancer. 2004 Jul;4(7):540-50
references: 15229479
references: Genes Dev. 2009 Apr 1;23(7):798-803
references: 19279323
references: Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210
references: 23847781
references: J Cell Biol. 1985 May;100(5):1466-73
references: 4039326
references: Int J Biochem Cell Biol. 2005 May;37(5):961-76
references: 15743671
references: Science. 2010 Apr 16;328(5976):321-6
references: 20395504
references: Curr Opin Cell Biol. 2010 Apr;22(2):234-40
references: 20045302
references: Mol Biol Cell. 1998 Aug;9(8):2185-200
references: 9693375
references: Biochem Biophys Res Commun. 2003 Apr 11;303(3):800-7
references: 12670482
references: Trends Genet. 2011 Jun;27(6):233-41
references: 21592610
references: Nat Cell Biol. 2011 May;13(5):506-12
references: 21540846
references: Mol Cell Biol. 2004 Aug;24(16):7298-311
references: 15282327
references: Nat Rev Mol Cell Biol. 2007 Sep;8(9):715-22
references: 17717516
references: Trends Mol Med. 2013 Jul;19(7):428-46
references: 23714574
references: Cell Cycle. 2007 Sep 1;6(17):2171-7
references: 17882791
references: Aging Cell. 2008 Dec;7(6):894-907
references: 18782348
references: Cell. 2008 Jun 13;133(6):1019-31
references: 18555778
references: Nat Rev Immunol. 2002 Mar;2(3):175-84
references: 11913068
references: Nat Cell Biol. 2006 Aug;8(8):877-84
references: 16862142
references: Aging (Albany NY). 2010 Mar 31;2(3):160-5
references: 20378935
references: Cancer Res. 2006 Sep 1;66(17):8356-60
references: 16951143
references: Exp Gerontol. 2004 Nov-Dec;39(11-12):1751-9
references: 15582292
references: J Cell Sci. 2000 Nov;113 ( Pt 22):4087-97
references: 11058095
references: Oncogene. 2003 May 8;22(18):2805-11
references: 12743603
references: Nat Rev Neurosci. 2007 May;8(5):368-78
references: 17453017
references: Aging (Albany NY). 2009 Apr 20;1(4):357-62
references: 20157523
references: J Exp Med. 1970 Jun 1;131(6):1211-22
references: 5419270
references: J Biol Chem. 2004 Oct 1;279(40):42270-8
references: 15263006
references: Nat Rev Cancer. 2010 Jan;10(1):51-7
references: 20029423
references: Science. 2006 May 19;312(5776):1059-63
references: 16645051
references: PLoS One. 2011;6(5):e20509
references: 21637828
references: Nat Cell Biol. 2004 Jul;6(7):609-17
references: 15220930
references: Cell. 2008 Jun 13;133(6):1006-18
references: 18555777
references: Cancer Sci. 2009 May;100(5):792-7
references: 19302284
references: Cell. 2007 Jul 27;130(2):223-33
references: 17662938
references: Mol Cell Biol. 2001 Mar;21(5):1552-64
references: 11238892
references: Nat Rev Mol Cell Biol. 2012 May 16;13(6):397-404
references: 22588366
references: J Cell Biol. 1993 Sep;122(6):1285-94
references: 8376463
references: Hum Pathol. 2010 Jun;41(6):886-94
references: 20233623
references: Nat Rev Cancer. 2002 Jun;2(6):442-54
references: 12189386
references: J Dent Res. 2011 Jul;90(7):830-40
references: 21447699
references: Exp Cell Res. 2008 Jun 10;314(9):1918-22
references: 18282568
references: Mech Ageing Dev. 2007 Jan;128(1):92-105
references: 17116321
references: Science. 2007 Aug 10;317(5839):803-6
references: 17690294
references: Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):839-48
references: 21093163
references: Genes Dev. 2000 Aug 15;14(16):2015-27
references: 10950866
references: Acta Physiol (Oxf). 2009 May;196(1):65-80
references: 19245654
references: J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1232-45
references: 17234816
references: Aging (Albany NY). 2011 Dec;3(12):1178-91
references: 22184282
references: In Vitro Cell Dev Biol Anim. 2006 Jul-Aug;42(7):216-24
references: 16948503
references: Cell Cycle. 2011 Jul 1;10(13):2059-63
references: 21654190
references: Nature. 2000 Jul 13;406(6792):207-10
references: 10910364
references: Aging (Albany NY). 2010 Jun;2(6):344-52
references: 20606252
references: Am J Pathol. 2010 May;176(5):2092-7
references: 20363920
references: Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8215-20
references: 18378900
references: J Biol Chem. 1999 Mar 19;274(12):7936-40
references: 10075689
references: Trends Pharmacol Sci. 2010 Feb;31(2):89-98
references: 20097433
references: Curr Opin Genet Dev. 2008 Feb;18(1):19-26
references: 18440219
references: Trends Mol Med. 2012 Sep;18(9):524-33
references: 22749019
references: Curr Opin Cell Biol. 2010 Apr;22(2):246-51
references: 20056398
references: Nature. 2005 Aug 11;436(7052):792
references: 16094359
references: Annu Rev Pathol. 2012;7:423-67
references: 22077552
references: Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17031-6
references: 19805069
references: Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7
references: 7568133
references: Nature. 2009 Sep 10;461(7261):282-6
references: 19741708
references: Annu Rev Med. 2003;54:131-52
references: 12525670
references: J Virol. 2007 Mar;81(5):2102-16
references: 17182682
references: Genetics. 2008 Dec;180(4):1787-97
references: 19087970
references: FEBS J. 2012 Aug;279(15):2610-23
references: 22621751
references: Cancer Res. 2006 Mar 15;66(6):2881-4
references: 16540631
references: Exp Gerontol. 2001 Aug;36(8):1327-47
references: 11602208
references: Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35
references: 21157483
references: Nucleic Acids Res. 2007;35(22):7505-13
references: 17986462
references: Aging (Albany NY). 2010 Jun;2(6):369-74
references: 20606249
references: Mech Ageing Dev. 1984 Aug;26(2-3):205-16
references: 6482519
references: Mol Cell. 2003 May;11(5):1163-76
references: 12769842
references: Annu Rev Physiol. 2013;75:685-705
references: 23140366
references: EMBO J. 2003 Aug 15;22(16):4212-22
references: 12912919
references: Nat Rev Drug Discov. 2011 Aug 31;10(9):671-84
references: 21878982
references: Cell Cycle. 2010 May 15;9(10):1859-62
references: 20436272
references: EMBO J. 2005 Sep 21;24(18):3301-12
references: 16107878
references: J Biol Chem. 2006 Dec 15;281(50):38519-28
references: 17032649
references: Mol Cancer Ther. 2011 Sep;10(9):1533-41
references: 21878654
references: Cancer Metastasis Rev. 2010 Jun;29(2):273-83
references: 20390322
references: Cell. 2008 Feb 8;132(3):363-74
references: 18267069
references: J Clin Invest. 2004 Nov;114(9):1299-307
references: 15520862
references: Nat Cell Biol. 2009 Aug;11(8):973-9
references: 19597488
references: Cancer Res. 2006 Mar 1;66(5):2708-15
references: 16510591
references: Cell. 2005 Feb 25;120(4):483-95
references: 15734681
references: Cancer Res. 2004 May 1;64(9):2956-61
references: 15126325
references: Aging (Albany NY). 2011 Jul;3(7):685-91
references: 21743107
references: Ann N Y Acad Sci. 2010 Jul;1201:65-71
references: 20649541
references: Aging (Albany NY). 2011 May;3(5):555-63
references: 21666284
references: J Biol Chem. 2000 Oct 6;275(40):31505-13
references: 10806201
references: Cell Death Dis. 2013 Oct 10;4:e838
references: 24113172
references: Age (Dordr). 2009 Dec;31(4):353-63
references: 19618294
references: Aging (Albany NY). 2010 May;2(5):311-4
references: 20519777
references: J Cell Sci. 2012 May 15;125(Pt 10):2349-58
references: 22641689
references: Aging (Albany NY). 2011 Apr;3(4):407-16
references: 21515933
references: Cancer Res. 2005 Aug 1;65(15):6734-44
references: 16061655
references: J Cell Physiol. 2006 Nov;209(2):468-80
references: 16883569
references: Mech Ageing Dev. 1980 Sep-Oct;14(1-2):59-79
references: 7010011
references: Ageing Res Rev. 2009 Jan;8(1):18-30
references: 18692159
references: Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13
references: 17717515
references: Br J Cancer. 2007 Mar 12;96(5):686-91
references: 17311013
references: Biochem J. 2003 Oct 15;375(Pt 2):263-74
references: 12871207
references: Trends Mol Med. 2010 May;16(5):238-46
references: 20444648
references: Mol Cell. 2009 Oct 9;36(1):2-14
references: 19818705
references: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16472-7
references: 17060621
references: Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):283-96
references: 22473468
references: Cell Growth Differ. 1997 May;8(5):589-98
references: 9149910
references: Autoimmun Rev. 2006 Feb;5(2):136-9
references: 16431345
references: J Biol Chem. 2006 Oct 6;281(40):29568-74
references: 16880208
references: J Biomed Sci. 2002;9(6 Pt 1):517-26
references: 12372989
references: Aging (Albany NY). 2009 May 16;1(6):542-56
references: 20157537
references: Exp Cell Res. 2003 Jul 15;287(2):272-81
references: 12837283
references: Cancer Res. 2003 Apr 15;63(8):1752-5
references: 12702556
references: Exp Cell Res. 2004 May 1;295(2):525-38
references: 15093749
references: Curr Biol. 2012 Sep 11;22(17):R741-52
references: 22975005
references: Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25
references: 14685170
references: Cell. 2003 Jun 13;113(6):703-16
references: 12809602
references: Genes Dev. 1998 Oct 1;12(19):2997-3007
references: 9765202
references: J Biol Chem. 2003 Oct 3;278(40):38966-9
references: 12871978
references: Nature. 2007 Feb 8;445(7128):656-60
references: 17251933
references: Semin Cancer Biol. 2006 Feb;16(1):38-52
references: 16139507
references: Nat Cell Biol. 2004 Feb;6(2):168-70
references: 14755273
references: Nat Chem Biol. 2011 Jan;7(1):9-17
references: 21164513
references: Genes Dev. 2010 Nov 15;24(22):2463-79
references: 21078816
references: J Cell Sci. 2011 Jan 1;124(Pt 1):68-81
references: 21118958
references: Antioxid Redox Signal. 2009 Jan;11(1):59-98
references: 18976161
references: Curr Mol Med. 2010 Jun;10(4):369-73
references: 20455855
references: FEBS Lett. 2008 Jun 18;582(14):2033-40
references: 18423404
references: J Cell Biol. 2012 Feb 20;196(4):395-406
references: 22351925
references: Nat Rev Mol Cell Biol. 2013 Jun;14(6):329-40
references: 23698583
references: J Cell Biol. 2006 Dec 18;175(6):869-80
references: 17158953
references: Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):76-84
references: 21115533
references: Trends Mol Med. 2013 Aug;19(8):447-53
references: 23769623
references: Exp Cell Res. 1961 Dec;25:585-621
references: 13905658
references: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
references: 16885212
references: Nat Rev Cancer. 2007 Dec;7(12):961-7
references: 17972889
references: Front Biosci (Landmark Ed). 2009 Jan 01;14(2):475-85
references: 19273079
references: Aging (Albany NY). 2010 Dec;2(12):900-7
references: 21191148
references: Mol Syst Biol. 2010;6:347
references: 20160708
references: DNA Cell Biol. 2001 Sep;20(9):509-29
references: 11747604
references: Genes Dev. 1998 Oct 1;12(19):3008-19
references: 9765203
references: J Cell Biol. 2011 Apr 18;193(2):257-66
references: 21502357
references: Aging (Albany NY). 2011 Sep;3(9):889-95
references: 21931180
references: Arch Gerontol Geriatr. 2002 May-Jun;34(3):249-61
references: 14764327
references: Mol Cell Biol. 2004 Apr;24(7):2808-19
references: 15024070
references: Nature. 2003 Nov 13;426(6963):194-8
references: 14608368
references: Physiology (Bethesda). 2008 Oct;23:248-62
references: 18927201
references: Clin Transl Oncol. 2010 Jun;12(6):410-7
references: 20534396
references: Eur J Cancer. 2006 Apr;42(6):768-78
references: 16510280
references: Aging (Albany NY). 2010 Aug;2(8):471-4
references: 20729567
references: Chromosoma. 2007 Oct;116(5):431-40
references: 17579878
references: Mol Cell Biol. 2000 Jan;20(1):273-85
references: 10594030
references: Mol Cell Biol. 2007 Apr;27(7):2452-65
references: 17242198