title: Barriers to the free diffusion of proteins and lipids in the plasma membrane.
abstract: Biological membranes segregate into specialized functional domains of distinct composition, which can persist for the entire life of the cell. How separation of their lipid and (glyco)protein components is generated and maintained is not well understood, but the existence of diffusional barriers has been proposed. Remarkably, the physical nature of such barriers and the manner whereby they impede the free diffusion of molecules in the plane of the membrane has rarely been studied in depth. Moreover, alternative mechanisms capable of generating membrane inhomogeneity are often disregarded. Here we describe prototypical biological systems where membrane segregation has been amply documented and discuss the role of diffusional barriers and other processes in the generation and maintenance of their structural and functional compartmentalization.
authors: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors: William S
authors: WS
authors: Trimble
authors: Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario M5C 1N8, Canada sergio.grinstein@sickkids.ca.
authors: Sergio
authors: S
authors: Grinstein
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D021961:Cell Membrane Structures / Q000378:metabolism; D048749:Cytokinesis; D004058:Diffusion; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins
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