title: Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation.
abstract: Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.
authors: Translational Tissue Engineering Center, Institute for Nanobiotechnology, Department of Biomedical Engineering, Johns Hopkins School of Medicine, 400 N Broadway, Baltimore, MD, 21231, USA.
authors: Randall A
authors: RA
authors: Meyer
authors: Joel C
authors: JC
authors: Sunshine
authors: Karlo
authors: K
authors: Perica
authors: Alyssa K
authors: AK
authors: Kosmides
authors: Kent
authors: K
authors: Aje
authors: Jonathan P
authors: JP
authors: Schneck
authors: Jordan J
authors: JJ
authors: Green
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens
keywords: CD8+ T-Cell activation; biomimetic; immunoengineering; nanoparticles; particle shape
references: Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13002-6
references: 24174264
references: Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10753-8
references: 23754411
references: Pharm Res. 2013 Oct;30(10):2512-22
references: 23314933
references: Biomaterials. 2014 Jan;35(1):269-277
references: 24099710
references: Nat Nanotechnol. 2007 Apr;2(4):249-55
references: 18654271
references: J Immunol. 1992 Oct 1;149(7):2402-5
references: 1527386
references: Mol Ther. 2008 Aug;16(8):1450-8
references: 18560419
references: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3270-5
references: 23401509
references: J Immunol. 2005 Mar 15;174(6):3204-11
references: 15749850
references: Biomaterials. 2014 Apr;35(12):3885-94
references: 24495486
references: ACS Nano. 2014 Mar 25;8(3):2252-60
references: 24564881
references: Drug Dev Ind Pharm. 2014 Feb;40(2):278-87
references: 23369094
references: Nanomedicine. 2014 Jan;10(1):119-29
references: 23891987
references: Biochem Biophys Res Commun. 2011 Aug 5;411(3):530-5
references: 21756876
references: J Control Release. 2010 Nov 1;147(3):408-12
references: 20691741
references: Nat Nanotechnol. 2010 Jan;5(1):42-7
references: 19893516
references: Nat Med. 2003 May;9(5):619-24
references: 12704385
references: Clin Immunol. 2003 Jan;106(1):16-22
references: 12584046
references: J Immunol. 1997 Dec 15;159(12):5921-30
references: 9550389
references: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11901-4
references: 17620615
references: Langmuir. 2010 Aug 17;26(16):13086-96
references: 20000620
references: Proc Natl Acad Sci U S A. 1978 Nov;75(11):5688-91
references: 310125
references: Small. 2012 Jul 23;8(14):2222-30
references: 22528663
references: Biomaterials. 2012 Aug;33(22):5504-13
references: 22579236
references: J Biol Chem. 2011 Oct 7;286(40):34883-92
references: 21849500
references: Nat Mater. 2007 Aug;6(8):557-62
references: 17667968
references: Bioorg Med Chem. 2013 Nov 1;21(21):6608-15
references: 24045007
references: Nat Biotechnol. 2004 Aug;22(8):969-76
references: 15258594
references: Nat Nanotechnol. 2014 Feb;9(2):148-55
references: 24463361
references: Mol Ther. 2008 Apr;16(4):765-72
references: 18334990
references: Cancer Res. 2009 Dec 15;69(24):9376-84
references: 19934317