title: Small interfering RNA treatment can inhibit Cyprinid herpesvirus 3 associated cell death in vitro.
abstract: A Cyprinid herpesvirus 3 infection of carp induces a disease which causes substantial losses in carp culture. Here we present the use of a possible strategy for the management of the virus infection RNA interference based on small interfering RNAs. As a result of in vitro studies, we found that a mixture of short interfering RNAs specific for viral DNA enzyme synthesis and capsid proteins of the CyHV-3 can be a potential inhibitor of virus replication in fibroblastic cells. This gives the basis for the development of a combinatorial RNA interference strategy to treat CyHV-3 infections.
authors: M
authors: M
authors: Adamek
authors: G
authors: G
authors: Rauch
authors: G
authors: G
authors: Brogden
authors: D
authors: D
authors: Steinhagen
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics / Q000378:metabolism*; D016923:Cell Death; D002460:Cell Line; D005347:Fibroblasts / Q000502:physiology / Q000821:virology*; D005399:Fishes; D015967:Gene Expression Regulation, Viral; D006564:Herpesviridae / Q000235:genetics / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000235:genetics*; D014779:Virus Replication
chemical_list: D036022:Capsid Proteins; D034741:RNA, Small Interfering