title: Overexpression of EGFR protein in Bruneian lung cancer patients.
abstract: BACKGROUND
  Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20% of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis.
  
  
  METHODS
  Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach.
  
  
  RESULTS
  The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression.
  
  
  CONCLUSIONS
  EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.
authors: PAPRSP Institute of Health Sciences, University of Brunei Darussalam, Gadong, Brunei Darussalam E-mail : mohamed.mabruk@.ubd.edu.bn ; mohamed.mabruk@gmail.com.
authors: Yu Hao
authors: YH
authors: Han
authors: Mas R W
authors: MR
authors: Abdul Hamid
authors: Pemasiri Upali
authors: PU
authors: Telisinghe
authors: Juniadah Binti
authors: JB
authors: Haji Hussin
authors: Mohamed
authors: M
authors: Mabruk
mesh_terms: D044466:Asian People; D002010:Brunei; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors