title: CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.
abstract: Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Suefen
authors: S
authors: Kwa
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Shanmugalakshmi
authors: S
authors: Sadagopal
authors: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
authors: Xiaoying
authors: X
authors: Shen
authors: Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
authors: Jung Joo
authors: JJ
authors: Hong
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Sailaja
authors: S
authors: Gangadhara
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Rahul
authors: R
authors: Basu
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Blandine
authors: B
authors: Victor
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors: Smita S
authors: SS
authors: Iyer
authors: Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
authors: Celia C
authors: CC
authors: LaBranche
authors: Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
authors: David C
authors: DC
authors: Montefiori
authors: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
authors: Georgia D
authors: GD
authors: Tomaras
authors: Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
authors: Francois
authors: F
authors: Villinger
authors: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors: Bernard
authors: B
authors: Moss
authors: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
authors: Pamela A
authors: PA
authors: Kozlowski
authors: Emory Vaccine Center, Department of Microbiology and Immunology, and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA ramara@emory.edu.
authors: Rama Rao
authors: RR
authors: Amara
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D023201:CD40 Ligand / Q000008:administration & dosage / Q000494:pharmacology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018604:Epitope Mapping; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D053208:Kaplan-Meier Estimate; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000235:genetics / Q000276:immunology / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D007074:Immunoglobulin G; D018449:SAIDS Vaccines; D023201:CD40 Ligand
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