title: Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.
abstract: Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.
authors: Huvet Co., Ltd., Iksan, Korea.
authors: Hak-Yong
authors: HY
authors: Lee
authors: Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea.
authors: Kwang-Hyun
authors: KH
authors: Park
authors: Huvet Co., Ltd., Iksan, Korea.
authors: Young-Mi
authors: YM
authors: Park
authors: Huvet Co., Ltd., Iksan, Korea.
authors: Dae-In
authors: DI
authors: Moon
authors: Huvet Co., Ltd., Iksan, Korea.
authors: Hong-Geun
authors: HG
authors: Oh
authors: Korea Food Research Institute, Seungnam, Korea.
authors: Dae-Young
authors: DY
authors: Kwon
authors: Korea Food Research Institute, Seungnam, Korea.
authors: Hye-Jeong
authors: HJ
authors: Yang
authors: Center for Animal Resources Development, Wonkwang University, Iksan, Korea.
authors: Okjin
authors: O
authors: Kim
authors: Center for Animal Resources Development, Wonkwang University, Iksan, Korea.
authors: Dong-Woo
authors: DW
authors: Kim
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Ji-Hyun
authors: JH
authors: Yoo
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Se-Chul
authors: SC
authors: Hong
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Kun-Hee
authors: KH
authors: Lee
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Su-Yeon
authors: SY
authors: Seol
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Yong-Sik
authors: YS
authors: Park
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Jong-Dae
authors: JD
authors: Park
authors: International Ginseng and Herb Research Institute, Geumsan, Korea.
authors: Mi-Kyung
authors: MK
authors: Pyo
keywords: High fat diet; dyslipidemia; hyperglycemia; red ginseng extract
references: J Ethnopharmacol. 2012 Jan 31;139(2):664-7
references: 22178175
references: J Ginseng Res. 2011 Sep;35(3):308-14
references: 23717074
references: J Ginseng Res. 2013 Mar;37(1):100-7
references: 23717163
references: J Korean Med Sci. 2001 Dec;16 Suppl:S28-37
references: 11748374
references: Biotechnol Lett. 2013 Jul;35(7):1017-22
references: 23515895
references: Planta Med. 2009 May;75(6):596-601
references: 19204893
references: Curr Vasc Pharmacol. 2009 Jul;7(3):293-302
references: 19601854
references: Lab Anim Res. 2012 Mar;28(1):23-9
references: 22474471
references: Neurosci Lett. 2008 Mar 21;434(1):1-5
references: 18313848
references: Arch Pharm Res. 2004 Nov;27(11):1136-40
references: 15595417
references: Food Sci Technol Int. 2013 Aug;19(4):323-33
references: 23729415
references: J Am Diet Assoc. 1999 Mar;99(3):294-9
references: 10076580
references: World J Microbiol Biotechnol. 2014 Mar;30(3):1019-1025
references: 24122127
references: Int J Obes Relat Metab Disord. 1997 Sep;21(9):715-37
references: 9376884
references: Fortschr Chem Org Naturst. 1984;46:1-76
references: 6396179
references: J Med Food. 2012 Nov;15(11):1015-23
references: 23126662
references: FASEB J. 2006 Jun;20(8):1269-71
references: 16636099
references: Diabetes Care. 2011 May;34(5):1071-6
references: 21411505
references: J Med Food. 2013 May;16(5):383-95
references: 23675990
references: Pulm Pharmacol. 1996 Aug;9(4):205-9
references: 9160407
references: J Nutr Biochem. 2010 Nov;21(11):1015-32
references: 20537520
references: Nutr Neurosci. 2014 Jan;17(1):7-15
references: 24088416
references: Diabetes. 2002 Jun;51(6):1851-8
references: 12031973
references: Ann N Y Acad Sci. 1999 Nov 18;892:146-54
references: 10842660
references: Food Sci Technol Int. 2013 Oct;19(5):399-406
references: 23729426
references: Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112
references: 16447287
references: Biosci Biotechnol Biochem. 2011;75(8):1490-5
references: 21821946
references: J Ginseng Res. 2013 Oct;37(4):425-34
references: 24233239
references: Nutrients. 2013 Oct 30;5(11):4316-32
references: 24177708
references: Phytomedicine. 2012 Jul 15;19(10):896-903
references: 22608480
references: J Pharm Pharmacol. 2005 Jul;57(7):911-8
references: 15969952
references: Diabetes Res Clin Pract. 2004 Sep;65 Suppl 1:S3-8
references: 15315864
references: Circulation. 2005 Nov 15;112(20):3184-209
references: 16286609
references: Cell. 2010 Jan 22;140(2):197-208
references: 20141834
references: J Agric Food Chem. 2012 Apr 11;60(14 ):3776-81
references: 22428991
references: J Ginseng Res. 2013 Mar;37(1):108-16
references: 23717164
references: Phytother Res. 2014 Apr;28(4):617-22
references: 23873605
references: Evid Based Complement Alternat Med. 2013;2013:502568
references: 24174975
references: J Clin Psychiatry. 2003 Dec;64(12):1426-35
references: 14728103