title: Bisphenol A Exposure in Children With Autism Spectrum Disorders.
abstract: The etiology of autism spectrum disorders (ASD) is believed to involve genetic and environmental components. This study focused on the plasticizer, Bisphenol-A (BPA). The major pathway for BPA metabolism and excretion is via glucuronidation. To determine whether there was a relationship between BPA exposure and ASD, urine specimens were collected from 46 children with ASD and 52 controls. Free and total BPA concentrations were determined by mass spectrometry. The fraction glucuronidated was calculated from the difference. A metabolomics study was done to investigate metabolite distribution in the urine. (i) Most of the BPA excreted in the urine was as the glucuronide; (ii) about 20% of the ASD children had BPA levels beyond the 90th percentile (>50 ng/mL) of the frequency distribution for the total sample of 98 children; (iii) Mann-Whitney U tests and multiple regression analyses found significant differences (P < 0.05) between the groups in total and % bound BPA; and (iv) the metabolomics analyses showed the number of absolute partial correlations >|0.30| between metabolite concentrations and total BPA was ∼3 times greater with the ASD group than the controls (P < 0.001), and the number of absolute partial correlations > |0.30| for % bound BPA was ∼15 times higher with ASD (P < 0.001). The results suggest there is an association between BPA and ASD.
authors: Department of Surgery, Rowan University-SOM, 2 Medical Center Drive, Stratford, New Jersey, 08084.
authors: T Peter
authors: TP
authors: Stein
authors: Department of Surgery, Rowan University-SOM, 2 Medical Center Drive, Stratford, New Jersey, 08084.
authors: Margaret D
authors: MD
authors: Schluter
authors: Department of Psychiatry, Rowan University-SOM, 2 Medical Center Drive, Stratford, New Jersey, 08084.
authors: Robert A
authors: RA
authors: Steer
authors: Metabolon Inc., 617 Davis Drive, Suite 400, Durham, North Carolina, 27713.|Department of Neurosciences and Neurology, Rutgers University -New Jersey Medical School, 90 Bergen Street, Newark, New Jersey, 07103.
authors: Lining
authors: L
authors: Guo
authors: Sleep Medicine Center, JFK Hospital, Seton Hall University, Edison, New Jersey, 08820.
authors: Xue
authors: X
authors: Ming
mesh_terms: D000067877:Autism Spectrum Disorder / Q000652:urine*; D001559:Benzhydryl Compounds / Q000652:urine*; D002648:Child; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D010636:Phenols / Q000652:urine*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: autism spectrum disorders; bisphenol A (BPA); glucuronidation; phthalates; plasticizers
references: Environ Res. 2009 Aug;109(6):734-7
references: 19463991
references: J Autism Dev Disord. 2013 Nov;43(11):2677-85
references: 23575644
references: Environ Sci Technol. 2013 Apr 2;47(7):3333-43
references: 23448553
references: Environ Health. 2013 Sep 13;12(1):80
references: 24034517
references: Pediatrics. 2011 Nov;128(5):873-82
references: 22025598
references: Sci Total Environ. 2008 Oct 1;404(1):26-35
references: 18632138
references: Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13056-61
references: 17670942
references: Neurotoxicology. 2011 Mar;32(2):261-7
references: 21182865
references: Reprod Toxicol. 2007 Aug-Sep;24(2):199-224
references: 17683900
references: Epidemiology. 2010 Sep;21(5):631-41
references: 20562626
references: Curr Opin Neurol. 2010 Apr;23(2):103-10
references: 20087183
references: Environ Health Perspect. 2011 Jul;119(7):914-20
references: 21450549
references: Environ Health Perspect. 2011 Jul;119(7):983-8
references: 21406337
references: Environ Health Perspect. 2008 Feb;116(2):173-8
references: 18288314
references: J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):27-34
references: 21605673
references: Crit Rev Toxicol. 2011 Apr;41(4):263-91
references: 21438738
references: Environ Health Perspect. 2013 May;121(5):586-93
references: 23425943
references: Environ Health Perspect. 2012 Jul;120(7):978-83
references: 22484414
references: Curr Opin Pediatr. 2011 Apr;23(2):233-9
references: 21293273
references: Environ Health Insights. 2008 Aug 20;2:55-9
references: 21572830
references: Environ Sci Technol. 2012 May 1;46(9):5003-9
references: 22489688
references: Endocrinology. 2012 Aug;153(8):3828-38
references: 22707478
references: J Autism Dev Disord. 2014 Dec;44(12):3063-71
references: 24958436
references: Pediatrics. 2004 May;113(5):e472-86
references: 15121991
references: Curr Opin Pediatr. 2010 Apr;22(2):219-25
references: 20087185
references: Environ Health Perspect. 2012 Jun;120(6):779-89
references: 22296744
references: Environ Health Perspect. 2011 Jan;119(1):131-7
references: 21205581
references: Neurotoxicology. 2009 Sep;30(5):822-31
references: 19822263
references: Mol Cell Endocrinol. 2012 May 6;354(1-2):74-84
references: 22249005
references: Birth Defects Res B Dev Reprod Toxicol. 2007 Aug;80(4):259-366
references: 17712860
references: J Proteome Res. 2012 Dec 7;11(12):5856-62
references: 23106572
references: Neurotoxicology. 2008 May;29(3):532-45
references: 18394707
references: Psychol Bull. 1992 Jul;112(1):155-9
references: 19565683
references: J Expo Sci Environ Epidemiol. 2013 Mar;23(2):120-7
references: 23188481