title: Hyperphosphatemia. The hidden killer in chronic kidney disease.
abstract: Hyperphosphatemia is a major cause of morbidity and mortality in patients with chronic kidney disease. The association between hyperphosphatemia and increased risk of death from cardiovascular disease/vascular calcification has been well established for a long time. This review explores the new aspects of pathogenesis of vascular calcification, as demonstrated by recent advances showing a recognized regulating role of phosphorus in vascular smooth muscle cell calcification. This novel mechanism may help in finding a new pharmacological therapy to reduce, or prevent blood vessel calcification. Furthermore, recent experimental and clinical studies involved in the treatment of hyperphosphatemia are reviewed in this article.
authors: Department of Medicine (38), King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 (11) 4690155. Fax. +966 (11) 4672671. E-mail. askakram@yahoo.com.
authors: Akram M
authors: AM
authors: Askar
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality*; D006801:Humans; D054559:Hyperphosphatemia / Q000150:complications* / Q000628:therapy; D010281:Parathyroid Hormone / Q000097:blood; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D061205:Vascular Calcification / Q000209:etiology*
chemical_list: D010281:Parathyroid Hormone
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