title: On the relationship between the rate of salivary flow and salivary fluoride clearance.
abstract: The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.
authors: Centre for Oral Health Research, School of Dental Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
authors: Ralph M
authors: RM
authors: Duckworth
authors: S
authors: S
authors: Jones
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000493:pharmacokinetics; D012463:Saliva / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects / Q000502:physiology; D012965:Sodium Chloride / Q000494:pharmacology; D012969:Sodium Fluoride / Q000032:analysis / Q000493:pharmacokinetics*; D013395:Sucrose / Q000494:pharmacology
chemical_list: D002327:Cariostatic Agents; D009067:Mouthwashes; D012965:Sodium Chloride; D013395:Sucrose; D012969:Sodium Fluoride