title: Transcription termination and the control of the transcriptome: why, where and how to stop.
abstract: Transcription termination occurs when the polymerase is released after a transcription event, thus delimitating transcription units; however, the functional importance of termination extends beyond the mere definition of gene borders. By determining the cellular fate of the generated transcripts, transcription termination pathways shape the transcriptome. Recent reports have underscored the crucial role of these pathways in limiting the extent of pervasive transcription, which has attracted interest in post-initiation events in gene expression control. Transcription termination pathways involved in the production of non-coding RNAs - such as the Nrd1-Nab3-Sen1 (NNS) pathway in yeast and the cap-binding complex (CBC)-ARS2 pathway in humans - are key determinants of transcription quality control. Understanding the mechanisms leading to the timely and efficient dismantling of elongation complexes remains a major unmet challenge, but new insights into the molecular basis of termination at mRNA-coding and non-coding RNA gene targets have been gained in eukaryotes.
authors: Institut Jacques Monod, Centre Nationale pour la Recherche Scientifique (CNRS), UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France.
authors: Odil
authors: O
authors: Porrua
authors: Institut Jacques Monod, Centre Nationale pour la Recherche Scientifique (CNRS), UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France.
authors: Domenico
authors: D
authors: Libri
mesh_terms: D000818:Animals; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D039381:RNA Cap-Binding Proteins / Q000235:genetics / Q000378:metabolism; D020365:RNA Helicases / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D061806:Transcription Termination, Genetic; D059467:Transcriptome
chemical_list: C090564:NAB3 protein, S cerevisiae; C491211:NRD1 protein, S cerevisiae; D009687:Nuclear Proteins; D039381:RNA Cap-Binding Proteins; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D012319:RNA Polymerase II; C542347:SEN1 protein, S cerevisiae; D004265:DNA Helicases; D020365:RNA Helicases
references: Cell. 2013 Aug 29;154(5):996-1009
references: 23993093
references: EMBO J. 1999 Oct 1;18(19):5399-410
references: 10508172
references: Genes Dev. 2005 Jul 1;19(13):1572-80
references: 15998810
references: Nat Struct Mol Biol. 2010 Oct;17(10):1195-201
references: 20818393
references: Mol Cell. 2012 Jul 27;47(2):267-80
references: 22683267
references: PLoS Genet. 2011 Nov;7(11):e1002379
references: 22102831
references: Genes Dev. 2009 Jun 1;23(11):1247-69
references: 19487567
references: Mol Cell. 2008 Mar 14;29(5):577-87
references: 18342605
references: J Biol Chem. 2013 Dec 20;288(51):36676-90
references: 24196955
references: Genes Dev. 2008 Apr 15;22(8):1082-92
references: 18413718
references: Mol Cell Biol. 2008 Jun;28(12):3883-93
references: 18426909
references: Genes Dev. 2006 Apr 15;20(8):954-65
references: 16598041
references: Mol Cell. 2013 Nov 21;52(4):473-84
references: 24267449
references: EMBO J. 2002 Apr 2;21(7):1800-10
references: 11927564
references: Genes Dev. 2011 Jan 1;25(1):29-40
references: 21156811
references: Chromosoma. 2002 Mar;111(1):1-12
references: 12068918
references: Cell Rep. 2014 Nov 6;9(3):821-8
references: 25437538
references: Nat Struct Mol Biol. 2008 Jan;15(1):71-8
references: 18157150
references: Mol Cell. 2012 Jan 13;45(1):87-98
references: 22244333
references: Mol Cell. 1999 Mar;3(3):379-87
references: 10198640
references: Nat Struct Mol Biol. 2008 Dec;15(12):1263-71
references: 19011635
references: PLoS Genet. 2011 Oct;7(10):e1002329
references: 22028667
references: Nature. 2014 Dec 18;516(7531):436-9
references: 25296254
references: Biochem Soc Trans. 2008 Aug;36(Pt 4):590-4
references: 18631122
references: Mol Cell. 2009 Oct 9;36(1):88-98
references: 19818712
references: EMBO J. 2000 Nov 15;19(22):6218-29
references: 11080167
references: Mol Cell Biol. 2006 May;26(10):3986-96
references: 16648491
references: Genet Res Int. 2011;2011:653494
references: 22567365
references: Nature. 2009 Feb 19;457(7232):1033-7
references: 19169243
references: Annu Rev Biophys. 2008;37:337-52
references: 18573085
references: Nucleic Acids Res. 2014 Apr;42(7):4348-62
references: 24497191
references: Science. 2012 Jun 29;336(6089):1723-5
references: 22745433
references: Genes Dev. 2012 Sep 1;26(17):1891-6
references: 22892239
references: Mol Cell. 2006 Sep 15;23(6):853-64
references: 16973437
references: Mol Cell Biol. 2014 Jun;34(11):1894-910
references: 24591651
references: Mol Cell. 2011 Jun 24;42(6):794-805
references: 21700224
references: Nat Rev Mol Cell Biol. 2011 May;12(5):283-94
references: 21487437
references: Biochim Biophys Acta. 2013 Jan;1829(1):151-7
references: 22960598
references: Nature. 2003 Oct 16;425(6959):737-41
references: 14562106
references: Mol Cell. 2006 Jan 20;21(2):239-48
references: 16427013
references: Nat Struct Mol Biol. 2013 Aug;20(8):923-8
references: 23851456
references: Mol Cell. 2009 Nov 25;36(4):541-6
references: 19941815
references: Nature. 2009 Feb 19;457(7232):1038-42
references: 19169244
references: Science. 2008 Dec 19;322(5909):1845-8
references: 19056941
references: PLoS One. 2009 Jul 09;4(7):e6193
references: 19587781
references: Biochim Biophys Acta. 2013 Jan;1829(1):84-97
references: 22982198
references: Nature. 2004 Nov 25;432(7016):522-5
references: 15565158
references: Cell. 2012 Sep 14;150(6):1147-57
references: 22980978
references: Genes Dev. 2005 Jan 1;19(1):90-103
references: 15630021
references: Nat Struct Mol Biol. 2010 Oct;17(10):1279-86
references: 20835241
references: Nat Struct Mol Biol. 2014 Feb;21(2):175-179
references: 24413056
references: Mol Cell. 2012 Jan 27;45(2):158-70
references: 22284676
references: Mol Cell. 2006 Sep 15;23(6):841-51
references: 16973436
references: Mol Cell. 2008 Jul 25;31(2):201-11
references: 18657503
references: J Bacteriol. 1986 Jun;166(3):945-58
references: 2423505
references: Science. 2011 Nov 4;334(6056):683-6
references: 22053051
references: Nature. 2001 Sep 20;413(6853):327-31
references: 11565036
references: J Biol Chem. 2009 Aug 7;284(32):21270-9
references: 19535338
references: Mol Cell. 2014 Aug 7;55(3):467-81
references: 25066235
references: Mol Cell. 2012 May 11;46(3):311-24
references: 22483619
references: Cell. 2012 Sep 14;150(6):1170-81
references: 22959267
references: RNA. 2013 Dec;19(12):1659-68
references: 24106327
references: Cell Rep. 2013 Apr 25;3(4):1080-92
references: 23562152
references: Mol Cell. 2012 Feb 24;45(4):470-82
references: 22264825
references: Genes Dev. 2005 Nov 15;19(22):2695-704
references: 16291644
references: Nat Struct Mol Biol. 2013 Jul;20(7):851-8
references: 23770821
references: RNA. 2007 Mar;13(3):361-73
references: 17237360
references: Mol Cell. 2014 Sep 4;55(5):745-57
references: 25192364
references: Science. 2012 Nov 2;338(6107):671-5
references: 23019609
references: Nat Struct Mol Biol. 2013 Dec;20(12):1358-66
references: 24270878
references: Cell. 2005 Oct 7;123(1):37-48
references: 16213211
references: Mol Cell. 2004 Jan 16;13(1):67-76
references: 14731395
references: Mol Cell. 2014 Dec 4;56(5):667-80
references: 25479637
references: EMBO J. 2004 Jun 16;23(12):2392-401
references: 15167896
references: Nat Struct Mol Biol. 2010 Oct;17(10):1272-8
references: 20818391
references: Mol Cell. 2006 Dec 8;24(5):735-746
references: 17157256
references: Mol Cell. 2012 Nov 9;48(3):409-21
references: 23000176
references: Mol Cell Biol. 2010 Nov;30(21):5110-22
references: 20805356
references: Mol Cell. 2006 Jan 6;21(1):65-74
references: 16387654
references: Nat Struct Mol Biol. 2013 Jul;20(7):884-91
references: 23748379
references: PLoS One. 2013 Dec 04;8(12):e80495
references: 24324601
references: EMBO J. 2004 Jan 28;23(2):354-64
references: 14739930
references: Nat Struct Mol Biol. 2008 Aug;15(8):786-94
references: 18660821
references: Nature. 2007 Dec 13;450(7172):1031-5
references: 18075583
references: Nat Struct Mol Biol. 2007 Jul;14(7):662-9
references: 17572685
references: Mol Cell. 2009 Oct 23;36(2):255-66
references: 19854134
references: Nature. 2011 Jun 22;475(7354):114-7
references: 21697827
references: Transcription. 2011 May;2(3):145-154
references: 21826286
references: EMBO J. 2012 Oct 3;31(19):3935-48
references: 23032188
references: Nature. 2013 Jul 18;499(7458):360-3
references: 23792564
references: Science. 2008 Dec 19;322(5909):1851-4
references: 19056938
references: Hum Mol Genet. 2009 Sep 15;18(18):3384-96
references: 19515850
references: Nature. 2004 Nov 25;432(7016):517-22
references: 15565157
references: Mol Cell Biol. 2011 Jan;31(2):328-41
references: 21078872
references: Mol Cell Biol. 2013 Dec;33(23):4718-31
references: 24081329
references: EMBO J. 2003 May 1;22(9):2167-77
references: 12727883
references: EMBO J. 2003 Jun 2;22(11):2831-40
references: 12773397
references: Chem Rev. 2013 Nov 13;113(11):8456-90
references: 23952966
references: Mol Cell. 2007 May 11;26(3):349-65
references: 17499042
references: Mol Cell Biol. 2005 Apr;25(8):3276-85
references: 15798211
references: EMBO J. 2011 May 4;30(9):1790-803
references: 21460797
references: Cell. 2014 Jun 19;157(7):1712-23
references: 24949978
references: Cell. 2011 Mar 4;144(5):745-56
references: 21376235
references: Mol Cell Biol. 2006 Apr;26(7):2688-96
references: 16537912
references: Mol Cell Biol. 2013 Jan;33(1):28-37
references: 23071092
references: Cell Rep. 2012 Oct 25;2(4):1025-35
references: 23062713
references: Science. 2008 Dec 19;322(5909):1849-51
references: 19056940
references: PLoS Genet. 2014 Oct 09;10(10):e1004632
references: 25299594
references: Genome Res. 2012 Aug;22(8):1447-56
references: 22684278
references: Nature. 2011 Jan 20;469(7330):368-73
references: 21248844
references: Nat Struct Mol Biol. 2014 Oct;21(10):919-26
references: 25240800
references: Nucleic Acids Res. 2014 Jan;42(1):264-75
references: 24097444
references: Nat Struct Mol Biol. 2010 Sep;17(9):1154-61
references: 20802488
references: Cell. 2005 Oct 21;123(2):265-76
references: 16239144
references: Genes Dev. 2012 Oct 1;26(19):2119-37
references: 23028141
references: Nat Commun. 2014 Jun 27;5:4263
references: 24968874
references: Mol Cell Biol. 2000 Jan;20(2):441-52
references: 10611222
references: Mol Cell. 2013 Jan 10;49(1):55-66
references: 23177741
references: J Biol Chem. 2013 Jul 5;288(27):19750-9
references: 23689372
references: Mol Cell. 2008 Sep 5;31(5):671-82
references: 18775327
references: Nat Struct Mol Biol. 2008 Aug;15(8):795-804
references: 18660819
references: Cell. 2009 May 1;137(3):445-58
references: 19410542
references: Nat Rev Genet. 2009 Dec;10(12):833-44
references: 19920851
references: EMBO J. 2012 May 16;31(10):2427-37
references: 22505027
references: Cell. 2005 Jun 3;121(5):725-37
references: 15935759
references: Mol Cell. 2009 Oct 9;36(1):99-109
references: 19818713
references: Mol Cell. 2006 Dec 8;24(5):723-734
references: 17157255
references: Biochim Biophys Acta. 2013 Jan;1829(1):174-85
references: 23085255
references: Cell Rep. 2013 Nov 27;5(4):1082-94
references: 24210826
references: Cell. 2013 Nov 21;155(5):1075-87
references: 24210918