title: Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation.
abstract: Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation.
authors: Xing-Xing
authors: XX
authors: Mei
authors: Jian
authors: J
authors: Wang
authors: Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200240; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China.
authors: Ji
authors: J
authors: Wu
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D000066673:Cell Self Renewal / Q000502:physiology*; D005298:Fertility / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D015398:Signal Transduction / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology
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