title: Label-free detection of zinc oxide nanowire using a graphene wrapping method.
abstract: Zinc oxide nanowires (ZnO NWs) have been attempted to various applications, such as piezoelectric devices, energy harvesting devices, self-powered nanosensors, and biomedical devices. However, recent reports have shown the toxic effect of ZnO NWs. In this report, we described the detection of ZnO NWs, for the first time using reduced graphene oxide (RGO) wrapping method. By wrapping RGO to ZnO NW (RGO-ZnO NW), we are able to aggregate ZnO NWs and increase the sensing performance. The detection measurement is based on the resonance frequency shift derived from mass variation of RGO-ZnO NW adsorption on the DNA immobilized resonator. The resonator is able to detect ZnO NWs with detection limit of 100 ng mL(-1) which is 2 order below the fatal toxic concentration of ZnO NWs in Human Monocyte Macrophages (HMMs). Furthermore, the resonator is able to detect ZnO NWs in real tap water, showing the potential as ZnO NWs screening platform in real environmental aqua system.
authors: Department of Mechanical Engineering, Korea University, Seoul 136-701, Republic of Korea.
authors: Juneseok
authors: J
authors: You
authors: Department of Mechanical Engineering, Korea University, Seoul 136-701, Republic of Korea.
authors: Kuewhan
authors: K
authors: Jang
authors: Department of Mechanical Engineering, Korea University, Seoul 136-701, Republic of Korea.
authors: Sangmyung
authors: S
authors: Lee
authors: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
authors: Doyeon
authors: D
authors: Bang
authors: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
authors: Seungjoo
authors: S
authors: Haam
authors: Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
authors: Chang-Hwan
authors: CH
authors: Choi
authors: Department of Control and Instrumentation Engineering, Korea University, Jochiwon 339-700, Republic of Korea. Electronic address: shinedew@korea.ac.kr.
authors: Jinsung
authors: J
authors: Park
authors: Department of Mechanical Engineering, Korea University, Seoul 136-701, Republic of Korea. Electronic address: nass@korea.ac.kr.
authors: Sungsoo
authors: S
authors: Na
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D061925:Immobilized Nucleic Acids / Q000737:chemistry; D057230:Limit of Detection; D053770:Nanowires / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D061925:Immobilized Nucleic Acids; D006108:Graphite; D015034:Zinc Oxide
keywords: Bioelectronics; Microelectromechanical systems; Nanowires; Sensors/biosensors; Zinc oxide