title: Highly sensitive glucose sensors based on enzyme-modified whole-graphene solution-gated transistors.
abstract: Noninvasive glucose detections are convenient techniques for the diagnosis of diabetes mellitus, which require high performance glucose sensors. However, conventional electrochemical glucose sensors are not sensitive enough for these applications. Here, highly sensitive glucose sensors are successfully realized based on whole-graphene solution-gated transistors with the graphene gate electrodes modified with an enzyme glucose oxidase. The sensitivity of the devices is dramatically improved by co-modifying the graphene gates with Pt nanoparticles due to the enhanced electrocatalytic activity of the electrodes. The sensing mechanism is attributed to the reaction of H2O2 generated by the oxidation of glucose near the gate. The optimized glucose sensors show the detection limits down to 0.5 μM and good selectivity, which are sensitive enough for non-invasive glucose detections in body fluids. The devices show the transconductances two orders of magnitude higher than that of a conventional silicon field effect transistor, which is the main reason for their high sensitivity. Moreover, the devices can be conveniently fabricated with low cost. Therefore, the whole-graphene solution-gated transistors are a high-performance sensing platform for not only glucose detections but also many other types of biosensors that may find practical applications in the near future.
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Meng
authors: M
authors: Zhang
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Caizhi
authors: C
authors: Liao
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Chun Hin
authors: CH
authors: Mak
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Peng
authors: P
authors: You
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Chee Leung
authors: CL
authors: Mak
authors: Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong.
authors: Feng
authors: F
authors: Yan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D005947:Glucose / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism*; D006108:Graphite; D006861:Hydrogen Peroxide / Q000378:metabolism; D014173:Transistors, Electronic
chemical_list: D006108:Graphite; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase; D005947:Glucose
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