title: Brucella and Coxiella; if you don't look, you don't find.
abstract: Brucella and Coxiella are similar; both are obligate intracellular, zoonotic pathogens with a broad geographic distribution. Infection in animals is usually asymptomatic, but causes fetal loss and therefore has significant economic impact. Human infection may be asymptomatic or give rise to either organ-specific or multi-system disease. Organism culture is challenging for Coxiella and can lack sensitivity for Brucella. Therefore, infection is most commonly diagnosed by serology, but this may be negative in early infection and serology results may be challenging to interpret. Both Brucella and Coxiella are typically susceptible to a wide range of antimicrobials, but long courses may be needed.
authors: Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, UK jonathan.lambourne@nhs.net.
authors: Jonathan R
authors: JR
authors: Lambourne
authors: Public Health England, Salisbury, UK.
authors: Tim
authors: T
authors: Brooks
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D002002:Brucella / Q000276:immunology / Q000302:isolation & purification*; D002006:Brucellosis / Q000175:diagnosis* / Q000276:immunology; D016997:Coxiella burnetii / Q000276:immunology / Q000302:isolation & purification*; D005188:False Negative Reactions; D006801:Humans; D011778:Q Fever / Q000175:diagnosis* / Q000276:immunology; D012698:Serologic Tests
chemical_list: D000907:Antibodies, Bacterial
keywords: Brucella; Coxiella; diagnosis; fever; zoonosis
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