title: The Impact of Marijuana Use on the Successful Aging of HIV-Infected Adults.
abstract: OBJECTIVE
  To determine the impact of self-reported marijuana use on the components of successful aging of HIV-infected persons.
  
  
  METHODS
  Cross-sectional study of 45- to 65-year-old HIV-infected subjects on antiretroviral therapy >6 months with undetectable HIV-1 viral load. Successful aging was defined as absence of disease, adequate physical function, high quality of life (QOL), and social engagement. Clinical characteristics, physical function assessments, and QOL from short form 36 were compared between groups defined by self-reported recent marijuana use (RMU), adjusted for tobacco use, CD4 T-cell count, and time since HIV diagnosis, using logistic or linear regression for binary or continuous measures.
  
  
  RESULTS
  93 of 359 total subjects (26%) reported RMU. Demographically, patients reporting RMU had been diagnosed with HIV less recently [14 (13-16) vs 11 (10-12) years], reported smoking (48% vs 25%) and lower income (92% vs 80%) with greater prevalence than non-RMU patients; other demographics and clinical characteristics (age, CD4 T-cell count) were similar. Gender, race/ethnicity, physical outcomes, physical function, and disease burden were not significantly different. Patients reporting RMU demonstrated lower mental QOL and increased odds of low social engagement and un- or under-employment compared with nonusers.
  
  
  CONCLUSIONS
  The negative association between RMU and mental or social QOL should be considered when assessing the success with which HIV patients reporting RMU are aging.
authors: *Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, CO; †Division of Geriatric Medicine, Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO; ‡Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO; and §College of Nursing, Univeristy of Colorado Denver, Aurora, CO.
authors: Amanda A
authors: AA
authors: Allshouse
authors: Sam
authors: S
authors: MaWhinney
authors: Catherine M
authors: CM
authors: Jankowski
authors: Wendy M
authors: WM
authors: Kohrt
authors: Thomas B
authors: TB
authors: Campbell
authors: Kristine M
authors: KM
authors: Erlandson
mesh_terms: D000368:Aged; D000375:Aging; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006802:Human Activities; D006801:Humans; D008297:Male; D008385:Marijuana Smoking; D008603:Mental Health; D008875:Middle Aged; D011788:Quality of Life; D016019:Survival Analysis
chemical_list: D044966:Anti-Retroviral Agents
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