title: Influence of living cells (L929) on the biodegradation of magnesium-calcium alloy.
abstract: In this study, the influence of living cells (L929) on the in vitro degradation behaviour of a magnesium-calcium alloy was investigated using an electrochemical technique in the Eagle's minimum essential medium (EMEM) with 10% foetal bovine serum (FBS) under 5% CO2 atmosphere. The degradation of the alloy increased significantly in the medium containing the cells as compared to that without cells. Post-degradation analysis revealed localized degradation in the vicinity of the cells. It is suggested that the cell metabolic activity has induced local pH drop and as a result increased the alloy degradation.
authors: Biomaterials and Engineering Materials (BEM) Laboratory, College of Science, Technology and Engineering, James Cook University, Townsville, Queensland 4811, Australia; Biometals Group, International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan. Electronic address: bobby.mathan@jcu.edu.au.
authors: M Bobby
authors: MB
authors: Kannan
authors: Biometals Group, International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan.
authors: A
authors: A
authors: Yamamoto
authors: Biomaterials and Engineering Materials (BEM) Laboratory, College of Science, Technology and Engineering, James Cook University, Townsville, Queensland 4811, Australia.
authors: Hadis
authors: H
authors: Khakbaz
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival; D055664:Electrochemical Techniques; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000737:chemistry / Q000378:metabolism*; D051379:Mice
chemical_list: D000497:Alloys; D008274:Magnesium; D002118:Calcium
keywords: Biomaterials; Degradation; L929 cells; Magnesium