title: VEGF111: new insights in tissue invasion.
abstract: Vascular endothelial growth factor is a secreted glycoprotein that acts on endothelial cells to induce developmental and physiological angiogenesis. It has also been implicated in angiogenesis occurring in several pathologies, most notably, cancer. Alternative splicing of VEGF mRNA transcripts results in several isoforms with distinct properties depending on their exon composition. Recently, a new isoform has been identified, VEGF111 with a unique exon composition responsible for its high angiogenic potential. In humans, the only known inducer of VEGF111 is DNA damage but its natural presence in the uterus of the viviparous lizard, Saiphos equalis, suggests other mechanisms of regulation. Most interestingly, the possible relationship between the evolution of viviparity and the associated increased risk in developing cancer may be important in understanding the mechanisms underlying tumor development.
authors: Discipline of Anatomy and Histology, School of Medical Sciences, Bosch Institute, The University of Sydney Sydney, NSW, Australia.
authors: Kevin
authors: K
authors: Danastas
authors: Discipline of Pathology, School of Medical Sciences, Bosch Institute, The University of Sydney Sydney, NSW, Australia.
authors: Valery
authors: V
authors: Combes
authors: Discipline of Anatomy and Histology, School of Medical Sciences, Bosch Institute, The University of Sydney Sydney, NSW, Australia.
authors: Laura A
authors: LA
authors: Lindsay
authors: Discipline of Pathology, School of Medical Sciences, Bosch Institute, The University of Sydney Sydney, NSW, Australia.
authors: Georges E R
authors: GE
authors: Grau
authors: School of Biological Sciences, The University of Sydney Sydney, NSW, Australia.
authors: Michael B
authors: MB
authors: Thompson
authors: Discipline of Anatomy and Histology, School of Medical Sciences, Bosch Institute, The University of Sydney Sydney, NSW, Australia.
authors: Christopher R
authors: CR
authors: Murphy
keywords: angiogenesis; cancer; metastasis; placentation; tumorigenesis; vascular endothelial growth factor
references: Nat Clin Pract Oncol. 2006 Jan;3(1):24-40
references: 16407877
references: J Exp Zool B Mol Dev Evol. 2010 Mar 15;314(2):148-56
references: 19676116
references: Cell. 2009 Mar 6;136(5):839-51
references: 19217150
references: Biochem Biophys Res Commun. 1989 Jun 15;161(2):851-8
references: 2735925
references: Nature. 1995 Jul 6;376(6535):62-6
references: 7596435
references: Curr Pharm Des. 2010;16(35):3864-76
references: 21158727
references: Endocr Rev. 2004 Aug;25(4):581-611
references: 15294883
references: Angiogenesis. 2013 Apr;16(2):353-71
references: 23254820
references: J Cell Sci. 1995 Jun;108 ( Pt 6):2369-79
references: 7673356
references: Med Hypotheses. 2006;66(5):888-97
references: 16455204
references: Cancer Cell. 2009 Mar 3;15(3):220-31
references: 19249680
references: J Biol Chem. 1992 Dec 25;267(36):26031-7
references: 1464614
references: Mol Endocrinol. 1991 Dec;5(12):1806-14
references: 1791831
references: Science. 1983 Feb 25;219(4587):983-5
references: 6823562
references: Science. 1992 Feb 21;255(5047):989-91
references: 1312256
references: Nat Rev Mol Cell Biol. 2006 May;7(5):359-71
references: 16633338
references: Cancer Res. 2000 Jan 15;60(2):203-12
references: 10667560
references: J Invest Dermatol. 2000 Jul;115(1):12-8
references: 10886501
references: J Exp Med. 1972 Aug 1;136(2):261-76
references: 5043412
references: Science. 1989 Dec 8;246(4935):1309-12
references: 2479987
references: J Biol Chem. 2003 May 9;278(19):17164-9
references: 12598527
references: J Cell Sci. 2001 Mar;114(Pt 5):853-65
references: 11181169
references: J Natl Cancer Inst. 1971 Dec;47(6):1333-44
references: 5120412
references: J Biol Chem. 1997 Mar 14;272(11):7151-8
references: 9054410
references: Nature. 2000 Sep 14;407(6801):249-57
references: 11001068
references: J Cell Biol. 2007 Dec 17;179(6):1261-73
references: 18086921
references: Science. 1989 Dec 8;246(4935):1306-9
references: 2479986
references: J Clin Endocrinol Metab. 1994 Jul;79(1):316-22
references: 8027247
references: Semin Reprod Endocrinol. 1999;17(3):275-90
references: 10797946
references: J Morphol. 2010 Nov;271(11):1342-51
references: 20715148
references: Biochem Biophys Res Commun. 1991 Dec 16;181(2):902-6
references: 1755866
references: Anat Rec (Hoboken). 2010 May;293(5):829-38
references: 20432373
references: J Cell Physiol. 1992 Dec;153(3):557-62
references: 1447317
references: Muscles Ligaments Tendons J. 2014 May 08;4(1):24-8
references: 24932443
references: Biochem Biophys Res Commun. 1992 Sep 30;187(3):1579-86
references: 1417831
references: Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8
references: 1946433
references: Evol Med Public Health. 2014 Oct 15;2014(1):136-45
references: 25324490
references: J Biol Chem. 1996 Mar 29;271(13):7788-95
references: 8631822
references: Cell Tissue Res. 2009 Jan;335(1):205-22
references: 18677515
references: PLoS One. 2013 Jul 23;8(7):e69687
references: 23936078
references: N Engl J Med. 1991 Jan 3;324(1):1-8
references: 1701519
references: Mol Cell Biol. 1995 Oct;15(10):5363-8
references: 7565686
references: Transplantation. 2013 Feb 15;95(3):426-33
references: 23380862