title: Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation.
abstract: Oral platelet aggregation inhibitors are widely used for the treatment and prevention of cardiovascular diseases, including coronary stent thrombosis. Premature discontinuation following percutaneous coronary intervention would pose a grave risk of in-stent thrombosis, acute myocardial infarction and eventual death. Although they share the same mechanism of adenosine diphosphate P2Y12 platelet receptor inhibition, they belong to either the chemical class of thienopyridines (clopidogrel, prasugrel, and ticlopidine) or cyclopentyl-triazolo-pyrimidines (ticagrelor and cangrelor). This case describes the first documented cross-reactive hypersensitivity of clopidogrel towards both its fellow thienopyridine, prasugrel, as well as the structurally dissimilar ticagrelor, and its subsequent successful desensitisation.
authors: Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
authors: Nicholas
authors: N
authors: Chin
authors: Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
authors: Kanishka
authors: K
authors: Rangamuwa
authors: Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
authors: Raymond
authors: R
authors: Mariasoosai
authors: Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia.
authors: Jonathan
authors: J
authors: Carnes
authors: Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria 3128, Australia. ; Professor of Respiratory Medicine, Allergy and Immunology, Monash University, Melbourne, Victoria 3145, Australia.
authors: Francis
authors: F
authors: Thien
keywords: Cross reactions; Desensitization, immunologic; Hypersensitivity; Platelet aggregation inhibitors
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