title: Olfactory function and quality of life following microscopic endonasal transsphenoidal pituitary surgery.
abstract: Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as a prospective cohort study set in a single tertiary hospital. A total of 53 patients with pituitary adenomas were included. All patients underwent pituitary surgery with the right-sided endonasal transsphenoidal approach. Outcomes were assessed with the Chinese version of the Medical Outcomes Study Short Form-36 (SF-36) to survey patient health, the Chinese version of the 22-item Sinonasal Outcome Test (SNOT-22), and a Toyota and Takagi (T&T) olfactometer. Assessments were carried out before surgery and at 1 week, and 1 and 4 months after surgery. The overall SF-36 scores were significantly lower, but the SNOT-22 scores were higher at 1 week and 1 month postoperatively compared with baseline (all P < 0.001). The results of T&T olfactometer testing showed that there was a significant decline in the ability to detect odors postoperatively, even at 4 months. Multivariate linear regression analysis showed that lower education level, partial tumor removal, and longer duration of surgery were independent risk factors for a higher SNOT-22 score at 1 week after surgery. The findings show that microscopic endonasal transsphenoidal pituitary surgery impairs olfactory function in most patients for at least 4 months after surgery.
authors: From the Department of Neurosurgery (SW, YC, LW, RW); Department of Otolaryngology (JL), Fuzhou General Hospital, Fujian Medical University, Fuzhou, P.R. China.
authors: Shousen
authors: S
authors: Wang
authors: Yehuang
authors: Y
authors: Chen
authors: Jianzhong
authors: J
authors: Li
authors: Liangfeng
authors: L
authors: Wei
authors: Rumi
authors: R
authors: Wang
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000328:Adult; D004522:Educational Status; D004724:Endoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D019635:Neurosurgical Procedures / Q000379:methods; D000857:Olfaction Disorders / Q000209:etiology*; D064367:Olfactometry; D061646:Operative Time; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors
references: Surg Neurol. 2006 Apr;65(4):332-41, discussion 341-2
references: 16531188
references: Int Forum Allergy Rhinol. 2011 May-Jun;1(3):161-6
references: 22287366
references: Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1355-9
references: 23081674
references: Br J Neurosurg. 2008 Oct;22(5):630-5
references: 18686060
references: Laryngoscope. 2011 Aug;121(8):1611-3
references: 21647916
references: Neurosurgery. 1993 Oct;33(4):610-7; discussion 617-8
references: 8232800
references: Laryngoscope. 2013 Jul;123(7):1602-6
references: 23798331
references: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jan;43(1):18-21
references: 18357706
references: Laryngoscope. 2013 Sep;123(9):2112-9
references: 23835915
references: Otolaryngol Head Neck Surg. 2010 Jan;142(1):95-7
references: 20096230
references: Laryngoscope. 2010 Jul;120(7):1292-7
references: 20578228
references: J Neurosurg. 2004 Feb;100(2):278-86
references: 15086236
references: J Otolaryngol Head Neck Surg. 2010 Jun;39(3):309-14
references: 20470678
references: Acta Neurochir (Wien). 2012 Oct;154(10):1895-902
references: 22922980
references: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb;48(2):92-4
references: 23710847
references: Pituitary. 2012 Sep;15(3):288-300
references: 22161543
references: Auris Nasus Larynx. 2007 Mar;34(1):57-63
references: 17141441
references: Laryngoscope. 2000 Jul;110(7):1071-7
references: 10892672
references: BMC Ear Nose Throat Disord. 2008 Oct 03;8:6
references: 18831771
references: Am J Rhinol Allergy. 2010 Jul-Aug;24(4):281-5
references: 20819467
references: Braz J Otorhinolaryngol. 2009 May-Jun;75(3):345-9
references: 19649482
references: Clin Otolaryngol. 2011 Jun;36(3):212-20
references: 21752205
references: Acta Otolaryngol. 2005 Feb;125(2):116-21
references: 15880938
references: Ann Otol Rhinol Laryngol. 2000 Aug;109(8 Pt 1):720-5
references: 10961803
references: ORL J Otorhinolaryngol Relat Spec. 1995 Sep-Oct;57(5):264-8
references: 8587779
references: Clin Otolaryngol. 2006 Apr;31(2):103-9
references: 16620328