title: Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways.
abstract: Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.
authors: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
authors: Guangxiu
authors: G
authors: Wang
authors: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
authors: Fang
authors: F
authors: Dai
authors: Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Kai
authors: K
authors: Yu
authors: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
authors: Zhifan
authors: Z
authors: Jia
authors: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
authors: Anling
authors: A
authors: Zhang
authors: Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, P.R. China.
authors: Qiang
authors: Q
authors: Huang
authors: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
authors: Chunsheng
authors: C
authors: Kang
authors: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA.
authors: Hao
authors: H
authors: Jiang
authors: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, P.R. China.
authors: Peiyu
authors: P
authors: Pu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D017209:Apoptosis; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation; D005910:Glioma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D051381:Rats; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D013267:Stilbenes / Q000008:administration & dosage* / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D035683:MicroRNAs; D013267:Stilbenes; D000077185:Resveratrol