title: The REDUCED (a RandomisED stUdy Comparing standard systemic anticoagulation thErapy to low Dose intracoronary anticoagulation therapy for elective percutaneous coronary intervention) trial. A novel pharmacologic regime for elective percutaneous coronary intervention.
abstract: OBJECTIVE
  This study tried to determine the efficacy and safety of low-dose intracoronary unfractionated heparin (UFH) in elective percutaneous coronary intervention (PCI).
  
  
  METHODS
  Two-hundred patients who underwent elective PCI of an uncomplicated lesion were included into the study. The patients were assigned to either a control group (70-100 IU/kg intravenous UFH) or a low-dose intracoronary UFH (1,000 IU intracoronary UFH) group.
  
  
  RESULTS
  At 30 days, the primary end point (composite of death, myocardial infarction, or urgent target vessel revascularization) was similar in both groups [intracoronary UFH group, 1.0%; control group, 2.0%; odds ratio; 0.49 (95% CI: 0.04 - 5.54), P = 0.56]. Post-procedural myocardial injury (according to CK-MB, P = 0.91; according to Tn I, P = 0.81) and bleeding events (based on TIMI criteria, P = 0.33; based on STEEPLE criteria, P = 0.20) were similar in the control and intracoronary groups. The primary end point at 6 months was also similar between the two groups (P = 0.33). Moreover, the health care cost at 30 days of follow-up was lower in the intracoronary group than in the control group (1,016 ± 54 $/patient vs 1,110 ± 102 $/patient, P < 0.001).
  
  
  CONCLUSIONS
  This pilot study suggests that elective PCI could be safely performed with low-dose intracoronary UFH in the treatment of uncomplicated lesions and at a lower cost as compared to standard systemic anticoagulation.These results should be confirmed by further studies.
authors: Hasan
authors: H
authors: Ari
authors: Eylem
authors: E
authors: Kivaç
authors: Selma
authors: S
authors: Ari
authors: Nadir
authors: N
authors: Emlek
authors: Seçkin
authors: S
authors: Cetinkaya
authors: Nuran
authors: N
authors: Celiloğlu
authors: O Yasar
authors: OY
authors: Sarigul
authors: Cihan
authors: C
authors: Aydin
authors: Mehmet
authors: M
authors: Akkaya
authors: Vedat
authors: V
authors: Koca
authors: Tahsin
authors: T
authors: Bozat
authors: Muhammet
authors: M
authors: Gurdogan
mesh_terms: D017023:Coronary Angiography; D004311:Double-Blind Method; D023381:Endpoint Determination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin