title: Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience.
abstract: BACKGROUND
  The aim of our multicenter study was to assess the clinical outcome and safety of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA).
  
  
  METHODS
  From May 2011 to February 2013, 42 women with 51 FA in one or both breasts were selected for treatment with US-guided HIFU. Eight of 51 FA were treated twice. Patients' age ranged from 16 to 52 years (mean 32 years). All patients with FA underwent core needle biopsy with histological confirmation. HIFU treatment was performed as an outpatient procedure under conscious sedation. Exclusion criteria were pregnant or lactating women, microcalcifications within the lesion at mammogram, history of breast cancer, previous laser or radiation therapy, and breast implant in the same breast. All patients signed written informed consent. After the treatment, follow-up US with volume evaluation was performed at 2, 6, and 12 months.
  
  
  RESULTS
  The FA mean baseline volume was 3.89 ml (0.34-19.66 ml). At 2-month follow-up, the mean volume reduction was 33.2% ± 19.1% and achieved significance at 6-month (59.2% ± 18.2%, p < 0.001) and 12-month (72.5% ± 16.7%, p < 0.001) follow-up. Related side effects as superficial skin burn with blister-like aspect in three patients and hyperpigmentation over the treated area in one patient were transient and resolved spontaneously. In one patient, asymptomatic subcutaneous induration persisted at the end of the study.
  
  
  CONCLUSIONS
  US-guided HIFU treatment is an effective noninvasive method for the treatment of breast FA and well tolerated by the patients. Preliminary results are encouraging and show that HIFU could be an alternative to surgery for breast FA.
authors: Department of Thyroid and Metabolic Bone Disorders, University Hospital of Endocrinology, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria.
authors: Roussanka
authors: R
authors: Kovatcheva
authors: Department of Gynecological Surgery, American Hospital of Paris, 63 Bld Victor Hugo, 92200 Neuilly-sur-Seine, France.
authors: Jean-Noël
authors: JN
authors: Guglielmina
authors: Department of Medical Imaging, American Hospital of Paris, 63 Bld Victor Hugo, 92200 Neuilly-sur-Seine, France.
authors: Marc
authors: M
authors: Abehsera
authors: Department of Gynecological and Breast Surgery, University Hospital of Lille, Ave Eugène Avinée, 59037 Lille, France.
authors: Loïc
authors: L
authors: Boulanger
authors: Department of Imaging, Regional Hospital of Valenciennes, Ave Désandrouin - BP 479, 59322 Valenciennes, France.
authors: Nicolas
authors: N
authors: Laurent
authors: Department of Imaging, Regional Hospital of Valenciennes, Ave Désandrouin - BP 479, 59322 Valenciennes, France.
authors: Edouard
authors: E
authors: Poncelet
keywords: Breast fibroadenoma; Minimally invasive treatment; Ultrasound (US)-guided high-intensity focused ultrasound (HIFU)
references: Ugeskr Laeger. 2003 May 5;165(19):1979-83
references: 12795072
references: World J Clin Oncol. 2011 Jan 10;2(1):8-27
references: 21603311
references: World J Surg. 1989 Nov-Dec;13(6):706-10
references: 2696223
references: Br J Surg. 1996 Feb;83(2):264-5
references: 8689184
references: Am J Surg. 2006 Oct;192(4):545-7
references: 16978972
references: World J Surg Oncol. 2014 Nov 10;12:335
references: 25382741
references: Breast. 2004 Dec;13(6):483-7
references: 15563855
references: J Magn Reson Imaging. 2008 Feb;27(2):391-9
references: 18219674
references: Top Magn Reson Imaging. 2006 Jun;17(3):181-8
references: 17414075
references: Eur Radiol. 2014 Sep;24(9):2052-8
references: 24895038
references: Clin Radiol. 2009 Apr;64(4):381-5
references: 19264182
references: Am J Surg. 2004 Sep;188(3):221-4
references: 15450823
references: Thyroid. 2009 Oct;19(10):1085-91
references: 19803790
references: Gland Surg. 2014 May;3(2):142-8
references: 25083508
references: Med J Aust. 2001 Feb 19;174(4):185-8
references: 11270760
references: Nephrol Dial Transplant. 2012 Jan;27(1):76-80
references: 22015443
references: Gynecol Obstet Fertil. 2008 Jul-Aug;36(7-8):788-99
references: 18650113
references: AJR Am J Roentgenol. 2010 Oct;195(4):830-5
references: 20858805
references: Am J Surg. 2005 Oct;190(4):647-51; discussion 651-2
references: 16164941
references: Thyroid. 2004 Dec;14 (12 ):1072-6
references: 15650361
references: Breast J. 2005 Sep-Oct;11(5):344-50
references: 16174156
references: Breast J. 2008 May-Jun;14 (3):275-8
references: 18397185
references: J Gen Intern Med. 1998 Sep;13(9):640-5
references: 9754521
references: Radiology. 2001 Apr;219(1):176-85
references: 11274554
references: Thyroid. 2011 Sep;21(9):965-73
references: 21834683