title: Incorporation of lutein and docosahexaenoic acid from dietary microalgae into the retina in quail.
abstract: Lutein and docosahexaenoic acid (DHA) are associated with the prevention of age-related macular degeneration (AMD). Since microalgae are potent natural sources of these nutrients, their nutritional value should be evaluated based on the bioavailability of lutein and DHA for the retina via the plasmatic compartment. In this study, quail were fed for 5 months either with a diet supplemented or deprived with microalgae rich in lutein and DHA. In the microalgae-fed group, the retinal concentrations of lutein and zeaxanthin gradually increased whereas in plasma, these compounds started to increase from the first month of supplementation. We also observed a significant increase in retinal and plasmatic levels of DHA in the microalgae-fed group. In conclusion, the plasmatic and retinal contents of lutein and DHA were significantly increased in quail fed with lutein- and DHA-rich microalgae. Food fortification with microalgae may be an innovative way to increase lutein and DHA consumption in humans.
authors: Service de Nutrition, Institut Pasteur de Lille , Lille Cedex , France .
authors: Coralie
authors: C
authors: Schnebelen-Berthier
authors: Niyazi
authors: N
authors: Acar
authors: Philippe
authors: P
authors: Pouillart
authors: Clementine
authors: C
authors: Thabuis
authors: Bertrand
authors: B
authors: Rodriguez
authors: Flore
authors: F
authors: Depeint
authors: Elise
authors: E
authors: Clerc
authors: Adeline
authors: A
authors: Mathiaud
authors: Anne
authors: A
authors: Bourdillon
authors: Blandine
authors: B
authors: Baert
authors: Lionel
authors: L
authors: Bretillon
authors: Jean-Michel
authors: JM
authors: Lecerf
mesh_terms: D000818:Animals; D001682:Biological Availability; D004032:Diet; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D014975:Lutein / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D008268:Macular Degeneration / Q000378:metabolism / Q000517:prevention & control; D058086:Microalgae / Q000737:chemistry*; D023421:Models, Animal; D011784:Quail; D012160:Retina / Q000378:metabolism*; D065146:Zeaxanthins / Q000378:metabolism
chemical_list: D065146:Zeaxanthins; D004281:Docosahexaenoic Acids; D014975:Lutein
keywords: Age-related macular degeneration; DHA; lutein; microalgae; quail; retina