title: Ameliorating effects of auricular electroacupuncture on rectal distention-induced gastric dysrhythmias in rats.
abstract: Gastric slow waves (GSW) are known to regulate gastric motility and are impaired with rectal distention (RD). Electroacupuncture (EA) at body acupoints, such as ST 36, has been shown to improve gastric dysrhythmias; however, little is known about the possible effects of auricular electroacupuncture (AEA) on GSW. To study effects and possible mechanisms of AEA on RD-induced gastric dysrhythmias in rats, ten male Sprague-Dawley (SD) rats implanted with gastric serosal electrodes were studied in two different experiments in fed state. Four sessions were performed in experiment 1 as follows: control (RD, no stimulation), RD+AEA, RD+EA at body points and RD+sham AEA. Two sessions were included in experiment 2 to study mechanisms of AEA: RD + atropine and RD + atropine + AEA. It was found that 1) RD significantly decreased the percentage of normal GSW from 89.8 ± 3.5% to 76.0 ± 3.3% (P<0.05); 2) AEA increased the percentage of normal GSW during RD to 94.0 ± 2.1% (P<0.05 vs. RD) via a reduction in the percentages of tachygastria and arrhythmia (P<0.05 vs. RD); 3) atropine blocked the ameliorating effect of AEA on RD-induced gastric dysrhythmias. Our results demonstrated that RD induces gastric dysrhythmias in fed state in rats. AEA improves RD-induced gastric dysrhythmias via the vagal pathway. AEA may have a therapeutic potential in treating gastric dysrhythmias.
authors: Department of Acupuncture, the First Affiliated Hospital, Nanjing Medical University, Nanjing, China; Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, United States.
authors: Zhaohui
authors: Z
authors: Zhang
authors: Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, United States.
authors: Jieyun
authors: J
authors: Yin
authors: Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, United States; Ningbo Pace Translational Medical Research Center, Beilun, Ningbo, China.
authors: Jiande D Z
authors: JD
authors: Chen
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D001285:Atropine / Q000009:adverse effects; D015671:Electroacupuncture; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum; D013272:Stomach Diseases / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D001285:Atropine
references: Dig Dis Sci. 2002 Feb;47(2):365-72
references: 11858233
references: Auton Neurosci. 2006 Jun 30;126-127:2-8
references: 16580267
references: Complement Ther Med. 2014 Feb;22(1):21-5
references: 24559812
references: FASEB J. 2004 Mar;18(3):439-56
references: 15003990
references: Brain Res. 2011 Jun 23;1397:19-27
references: 21596372
references: J Pharmacol Sci. 2004 Sep;96(1):1-10
references: 15351789
references: J Comp Physiol B. 2012 Jan;182(1):101-8
references: 21761139
references: Aliment Pharmacol Ther. 2000 Aug;14(8):1041-7
references: 10930898
references: Dig Dis Sci. 1998 Jan;43(1):80-9
references: 9508540
references: Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15;303(2):R209-17
references: 22592556
references: Card Electrophysiol Rev. 2002 Sep;6(3):256-61
references: 12114848
references: Neurogastroenterol Motil. 2008 Nov;20(11):1204-11
references: 18694444
references: Dig Dis Sci. 2002 Aug;47(8):1746-51
references: 12184525
references: Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G563-70
references: 20093561
references: Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R298-305
references: 20427716
references: Dig Dis Sci. 1996 Aug;41(8):1538-45
references: 8769276
references: Pharmacol Res. 2011 Oct;64(4):420-5
references: 21718784
references: Neurosci Lett. 2001 Jul 13;307(2):113-6
references: 11427313
references: Neuromodulation. 2011 Jan;14(1):8-12; discussion 12
references: 21992155
references: J Gastroenterol Hepatol. 2005 Apr;20(4):502-16
references: 15836697
references: Evid Based Complement Alternat Med. 2013;2013:894096
references: 24324522
references: Gastroenterology. 2003 Feb;124(2):401-9
references: 12557146
references: Aliment Pharmacol Ther. 2002 Jan;16(1):17-26
references: 11856074
references: Brain Res Bull. 1995;36(2):141-8
references: 7895091
references: J Altern Complement Med. 2010 Apr;16(4):435-47
references: 20423213
references: J Gastroenterol Hepatol. 2008 Jan;23(1):141-9
references: 18171353
references: Zhongguo Zhen Jiu. 2007 Apr;27(4):245-8
references: 17585664
references: J Altern Complement Med. 1998 Winter;4(4):399-403
references: 9884177
references: Dig Dis Sci. 2002 Nov;47(11):2473-9
references: 12452382
references: Dig Dis Sci. 2003 Mar;48(3):508-15
references: 12757162
references: Neurogastroenterol Motil. 2010 Nov;22(11):1217-23, e318
references: 20723072
references: Med Hypotheses. 2011 Aug;77(2):244-5
references: 21601370
references: Zhongguo Zhen Jiu. 2009 Jan;29(1):3-6
references: 19186712
references: Dig Dis Sci. 2000 Sep;45(9):1731-6
references: 11052312
references: J Clin Gastroenterol. 2010 May-Jun;44(5):335-9
references: 20195164
references: Auton Neurosci. 2007 Dec 30;137(1-2):67-76
references: 17884736
references: Auton Neurosci. 2011 Nov 16;165(1):80-101
references: 20724224
references: Auton Neurosci. 2008 Feb 29;138(1-2):50-6
references: 18068545
references: Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G614-20
references: 18653722
references: J Neural Transm (Vienna). 2007;114(11):1485-93
references: 17564758
references: Dig Dis Sci. 2006 Dec;51(12):2154-9
references: 17082991
references: Vopr Kurortol Fizioter Lech Fiz Kult. 1999 Sep-Oct;(5):12-4
references: 10598521
references: J Gastroenterol. 2006 May;41(5):408-17
references: 16799881
references: Acupunct Med. 2013 Mar;31(1):57-64
references: 23211189
references: Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R465-72
references: 21593428
references: Evid Based Complement Alternat Med. 2007 Sep;4(Suppl 1):13-6
references: 18227925