title: Laser induced injury caused hyperglycemia-like effect in Drosophila larva: a possible insect model for posttraumatic diabetes.
abstract: Diabetic patients need particular care in case of infection, digestive disorder or external injury, because external stress often exasperates the glucose metabolism, which is known as "sick day management". In addition, severe trauma can be a cause of hyperglycemia with insulin resistance. In spite of critical component of the treatment, the precise mechanisms of how trauma develops posttraumatic diabetes remain unknown. Here, we ablated body wall muscles in Drosophila larvae by laser beam and found that the level of trehalose, the principal sugar circulating in the hemolymph or in the tissues of most insects, was increased. The model may provide a helpful tool to understand the relationship between trauma and sugar metabolism.
authors: Department of Life Science, Division of Natural Sciences, International Christian University, Mitaka, Tokyo 181-8585, Japan.
authors: Fumio
authors: F
authors: Okabe
authors: Yoko
authors: Y
authors: Nakagiri
authors: Takahisa
authors: T
authors: Yamada
authors: Hiroyuki
authors: H
authors: Kose
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila / Q000378:metabolism* / Q000528:radiation effects*; D005947:Glucose / Q000378:metabolism*; D007814:Larva / Q000378:metabolism / Q000528:radiation effects; D007834:Lasers
chemical_list: D005947:Glucose
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