title: Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease.
abstract: A male with sickle SC disease presented at age 8 years with proliferative sickle cell retinopathy (PSCR) and bilateral vitreous hemorrhage which spontaneously resolved, then recurred at 13 years of age. Despite conventional therapy with repeated pan-retinal photocoagulation and pars plana vitrectomy, he developed progressive PSCR and recurrent vitreous hemorrhage over the next 30 months. We describe the successful use of chronic red cell exchange transfusion (RCE) to preserve his vision and stabilize the retinopathy.
authors: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado Denver, Aurora, Colorado.
authors: Christopher M
authors: CM
authors: McKinney
authors: Frank
authors: F
authors: Siringo
authors: Jeffrey L
authors: JL
authors: Olson
authors: Kelly E
authors: KE
authors: Capocelli
authors: Daniel R
authors: DR
authors: Ambruso
authors: Rachelle
authors: R
authors: Nuss
mesh_terms: D000293:Adolescent; D002648:Child; D017707:Erythrocyte Transfusion; D006450:Hemoglobin SC Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D012164:Retinal Diseases / Q000209:etiology / Q000628:therapy*; D014823:Vitreous Hemorrhage / Q000209:etiology / Q000628:therapy*
keywords: hemoglobin SC disease; red cell exchange; retinopathy; sickle cell