title: Ent-Kaurane diterpenes from Annona glabra and their cytotoxic activities.
abstract: A new ent-kaurane glycoside, annoglabasin H (1), and three known ent-kauranes, annoglabasin E (2), annoglabasin B (3), and 19-nor-ent-kaurent-4-ol-17-oic acid (4) were isolated from the fruits of Annona glabra. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D- and 2D-NMR spectroscopy, as well as by comparison with the NMR data reported in the literature. The cytotoxic activities of these compounds were evaluated on four human cancer cell lines, LU-1, MCF-7, SK-Mel2, and KB. Compound 1 exhibited significant cytotoxic activity on all tested human cancer cell lines with IC50 values ranging from 3.7 to 4.6 μM.
authors: Hoang Le Tuan
authors: Hle T
authors: Anh
authors: Nguyen Thi Thu
authors: NT
authors: Hien
authors: Dan Thi Thuy
authors: DT
authors: Hang
authors: Tran Minh
authors: TM
authors: Ha
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Truong Thi Thu
authors: TT
authors: Hien
authors: Vu Kim
authors: VK
authors: Thu
authors: Do Thi
authors: do T
authors: Thao
authors: Chau
authors: C
authors: Van Minh
authors: Phan Van
authors: PV
authors: Kiem
mesh_terms: D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane