title: The association between leukocyte telomere lengths and sleep instability based on cardiopulmonary coupling analysis.
abstract: OBJECTIVE
  The purpose of the study is to examine the objective association between sleep stability and leukocyte telomere lengths (LTL) using cardiopulmonary coupling (CPC) analysis, which is an electrocardiogram (ECG)-based technique to quantify physiologic sleep stability.
  
  
  METHODS
  Three hundred eighty-one healthy subjects were recruited from a community-based cohort study from the Korean Genome and Epidemiology Study (KoGES), and the associations between LTL and total quantities of different frequency coupling bands were examined using generalized linear model (GLM) with adjustment of significant covariates.
  
  
  RESULTS
  LTL showed a significant association with elevated narrow-band low frequency coupling (e-LFCNB, a CPC marker of periodic breathing or sleep fragmentation due to pathological respiratory chemoreflex activation) by interacting with obstructive sleep apnea (OSA) severity (p value of <0.0001). Especially, sleep stability significantly reduced with shortened LTL in OSA patients (Apnea-Hypopnea Index (AHI) ≥15) based on increased e-LFCNB which had a negative correlation with high-frequency coupling band (HFC), a marker of stable sleep.
  
  
  CONCLUSIONS
  The present study suggested that shorter LTL might contribute to reduced sleep stability by interacting with OSA severity due to the stress of chronic sleep fragmentation or invariant sympathetic activity by respiratory chemoreflex activation.
authors: Institute of Human Genomic Study, Korea Unversity Ansan Medical Center, Korea University, Seoul, Korea.
authors: Amy M
authors: AM
authors: Kwon
authors: Inkyung
authors: I
authors: Baik
authors: Robert J
authors: RJ
authors: Thomas
authors: Chol
authors: C
authors: Shin
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003700:Delta Rhythm / Q000502:physiology; D004562:Electrocardiography; D004569:Electroencephalography; D005583:Fourier Analysis; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D056910:Republic of Korea; D012815:Signal Processing, Computer-Assisted; D020181:Sleep Apnea, Obstructive / Q000235:genetics* / Q000503:physiopathology*; D012892:Sleep Deprivation / Q000235:genetics* / Q000503:physiopathology*; D013223:Statistics as Topic; D059506:Telomere Shortening / Q000502:physiology*
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