title: Large-sized Fetal Striatal Grafts in Huntington's Disease Do Stop Growing: Long-term Monitoring in the Florence Experience.
abstract: Development of six large nodules of solid tissue after bilateral human fetal striatal transplantation in four Huntington's disease patients has raised concern about the safety of this experimental therapy in our setting. We investigated by serial MRI-based volumetric analysis the growth behaviour of such grafts. After 33-73 months from transplantation the size of five grafts was stable and one graft showed a mild decrease in size. Signs neither of intracranial hypertension nor of adjuctive focal neurological deficit have ever been observed. This supports long-term safety of the grafting procedure at our Institution.
authors: Quantitative and Functional Neuroradiology Research Unit, Meyer Children and Careggi Hospitals, Florence, Italy; Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.
authors: Mario
authors: M
authors: Mascalchi
authors: Department of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
authors: Stefano
authors: S
authors: Diciotti
authors: Neurology Unit, Careggi Hospital, Florence, Italy.
authors: Marco
authors: M
authors: Paganini
authors: Andrea
authors: A
authors: Bianchi
authors: Neuroradiology Unit, Careggi Hospital, Florence, Italy.
authors: Andrea
authors: A
authors: Ginestroni
authors: Hematology Unit, Careggi Hospital, Florence, Italy.
authors: Letizia
authors: L
authors: Lombardini
authors: Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.
authors: Berardino
authors: B
authors: Porfirio
authors: University of Florence.
authors: Renato
authors: R
authors: Conti
authors: Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
authors: Nicola
authors: N
authors: Di Lorenzo
authors: Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
authors: Gabriella Barbara
authors: GB
authors: Vannelli
authors: Department of Surgery and Translational Medicine, University of Florence, Italy.
authors: Pasquale
authors: P
authors: Gallina
references: J Neurosurg. 1998 Oct;89(4):592-8
references: 9761053
references: J Neurol Neurosurg Psychiatry. 2014 Sep;85(9):950
references: 24403286
references: Exp Neurol. 2011 Jan;227(1):1-9
references: 20849848
references: Lancet Neurol. 2006 Apr;5(4):303-9
references: 16545746
references: J Neurol Neurosurg Psychiatry. 2008 Aug;79(8):948-51
references: 18356253
references: Exp Neurol. 2014 Jul;257:130-47
references: 24792640
references: J Neurol Neurosurg Psychiatry. 2014 Sep;85(9):974-81
references: 24347577
references: Stem Cells. 2009 Dec;27(12):2928-40
references: 19725119
references: Neuropathol Appl Neurobiol. 2014 Feb;40(1):71-90
references: 24304236
references: J Neurol Neurosurg Psychiatry. 2013 Jun;84(6):657-65
references: 23345280
references: Exp Neurol. 2010 Mar;222(1):30-41
references: 20026043
references: Neuroscience. 2006 Sep 29;142(1):287-304
references: 17120358
references: Neurology. 1996 May;46(5):1219-25
references: 8628456
references: Stereotact Funct Neurosurg. 2014;92 (4):211-7
references: 25096235
references: Acta Neuropathol. 2009 Mar;117(3):329-38
references: 19057918