title: Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.
abstract: OBJECTIVE
  This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.
  
  
  METHODS
  The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.
  
  
  RESULTS
  Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.
  
  
  CONCLUSIONS
  The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Muyesser Sayki
authors: MS
authors: Arslan
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Oya
authors: O
authors: Topaloglu
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Bekir
authors: B
authors: Ucan
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Melia
authors: M
authors: Karakose
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Basak
authors: B
authors: Karbek
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Esra
authors: E
authors: Tutal
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Mustafa
authors: M
authors: Caliskan
authors: Department of Biochemistry, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Zeynep
authors: Z
authors: Ginis
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Erman
authors: E
authors: Cakal
authors: Department of Endocrinology and Metabolism, School of Medicine, Ankara University, 06230 Ankara, Turkey.
authors: Mustafa
authors: M
authors: Sahin
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
authors: Mustafa
authors: M
authors: Ozbek
authors: Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey ; Translational Research Center, Diskapi Teaching and Research Hospital, 06330 Ankara, Turkey ; Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, 06330 Ankara, Turkey.
authors: Tuncay
authors: T
authors: Delibasi
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D005067:Euthyroid Sick Syndromes / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D013577:Syndrome; D013961:Thyroid Gland / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000209:etiology*; D013972:Thyrotropin / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D014807:Vitamin D; D013972:Thyrotropin
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