title: Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.
  
  
  METHODS
  Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.
  
  
  RESULTS
  Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28-1.82, P < 0.01, I (2) = 0%; CC versus TT: OR = 2.58, 95% CI = 1.74-3.82, P < 0.01, I (2) = 0%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14-1.84, P < 0.01, I (2) = 0%; CC versus TT + TC: OR=2.46, 95% CI = 1.46-4.14, P < 0.01, I(2) = 47.0%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50-0.96, P = 0.03, I(2) = 68.5%; TC versus TT: OR = 0.52, 95% CI = 0.40-0.68, P < 0.01, I(2) = 0%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35-0.78, P < 0.010, I(2) = 54.4%).
  
  
  CONCLUSIONS
  This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.
authors: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China ; Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China.
authors: Yuan-Yuan
authors: YY
authors: Hu
authors: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China.
authors: Chuan-Qi
authors: CQ
authors: Qin
authors: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China.
authors: Mo-Hong
authors: MH
authors: Deng
authors: Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China.
authors: Yu-Ming
authors: YM
authors: Niu
authors: Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China.
authors: Xing
authors: X
authors: Long
mesh_terms: D055415:Bone Morphogenetic Protein 4 / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D002681:China; D002971:Cleft Lip / Q000208:ethnology / Q000235:genetics*; D002972:Cleft Palate / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C525809:BMP4 protein, human; D055415:Bone Morphogenetic Protein 4
references: Eur J Oral Sci. 2014 Apr;122(2):109-13
references: 24460828
references: Development. 2005 Mar;132(6):1453-61
references: 15716346
references: Genomics. 1995 Jun 10;27(3):559-60
references: 7558046
references: Differentiation. 2003 Apr;71(3):228-36
references: 12694205
references: DNA Cell Biol. 2008 Nov;27(11):601-5
references: 18771417
references: Adv Otorhinolaryngol. 2011;70:107-13
references: 21358192
references: Birth Defects Res A Clin Mol Teratol. 2010 Jan;88(1):41-7
references: 19691087
references: Mol Med Rep. 2013 Oct;8(4):1228-34
references: 23921572
references: J Dent Res. 2012 May;91(5):473-8
references: 22370446
references: Am J Epidemiol. 2014 Feb 1;179(3):267-81
references: 24243742
references: Cleft Palate Craniofac J. 2013 Nov;50(6):633-8
references: 23237431
references: Arch Oral Biol. 2000 Feb;45(2):133-40
references: 10716617
references: Int J Oral Maxillofac Surg. 2010 Jan;39(1):50-6
references: 19914800
references: J Hum Genet. 1999;44(1):76-7
references: 9929985
references: Plast Surg Int. 2012;2012:247104
references: 23227324
references: J Anat. 2005 Nov;207(5):461-77
references: 16313388