title: ID4 gene polymorphism and osteoporosis in Thai menopausal women.
abstract: BACKGROUND
  The inhibitor of DNA binding 4 (ID4) protein regulates osteogenic and adipogenic cell fate and lack of lD4 gene expression decreased osteoblast differentiation. Variant in the ID4 gene polymorphism has not been reported with osteoporosis.
  
  
  OBJECTIVE
  To identify whether ID4 can be a marker gene for osteoporosis in Thai menopausal women.
  
  
  METHODS
  The 3 'UTR of lD4 (rs3798339) single nucleotide polymorphism was examined bypolymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), together with lumbar spine bone mineral density (BAMD) in 160 Thai menopausal women.
  
  
  RESULTS
  Lumbar spine 3 (L3) had a significantly lower BMD score in women with the TT genotype, compared with the CT+CC genotypes (p = 0.037). This disappeared after the adjustment of various factors.
  
  
  CONCLUSIONS
  The polymorphism at 3'UTR of lD4 gene can alter ID4 mRNA stability, and may be linked to the function of proteins. However, this needs confirmation in larger populations. The present study is useful as an initial investigation into ID4 gene polymorphism in osteoporosis.
authors: Chaowanee
authors: C
authors: Chupeerach
authors: Sirikul
authors: S
authors: Kulanuwat
authors: Wanida
authors: W
authors: Chuenta
authors: Sivaporn
authors: S
authors: Wannaiampikul
authors: Vanessa Anne
authors: VA
authors: Schuh
authors: Sangchai
authors: S
authors: Preutthipan
authors: Rungsunn
authors: R
authors: Tungtrongchitr
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People; D015519:Bone Density / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics*; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D013785:Thailand
chemical_list: D020413:3' Untranslated Regions; C490128:ID4 protein, human; D051796:Inhibitor of Differentiation Proteins