title: Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis.
abstract: BACKGROUND
  The aim of this study was to identify factors predicting histologic chorioamnionitis (HCA) in women with preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  We retrospectively enrolled 371 women diagnosed with PPROM at less than 34 weeks of gestation at the Second Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2012. HCA was diagnosed by placental histopathology in 70% of participants. Binary logistic regression was used to identify factors associated with HCA and neonatal outcomes.
  
  
  RESULTS
  Patient age, rate of parity, tocolysis, cesarean section, serum C reactive protein (CRP) level at admission, white blood cell count, and latency duration did not significantly differ between the 2 groups. Binary logistic regression revealed that oligohydramnios at admission, gestational age at PPROM, and serum CRP >8 mg/L before delivery were significantly associated with HCA. Gestational age at delivery and birth weight were significantly lower in HCA patients than control patients. The rate of 1-min Apgar score <7, abnormal neonatal intracranial ultrasound findings, neonatal pneumonia, bronchopulmonary dysplasia, early-onset neonatal sepsis, and mortality were higher in HCA patients, but no significant difference was observed in the incidence of neonatal respiratory distress syndrome, necrotizing enterocolitis, hyperbilirubinemia, or hypoglycemia.
  
  
  CONCLUSIONS
  Younger gestational age at time of PPROM, higher CRP level before delivery, and oligohydramnios at admission in women with PPROM are associated with HCA, and HCA is associated with some adverse neonatal outcomes.
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Ailan
authors: A
authors: Xie
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Wenwen
authors: W
authors: Zhang
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Miaomiao
authors: M
authors: Chen
authors: Department of Gynecology, econd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Yuhuan
authors: Y
authors: Wang
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Ying
authors: Y
authors: Wang
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Qingfeng
authors: Q
authors: Zhou
authors: Department of Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Xueqiong
authors: X
authors: Zhu
mesh_terms: D001034:Apgar Score; D002097:C-Reactive Protein / Q000378:metabolism; D002821:Chorioamnionitis / Q000503:physiopathology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000473:pathology*; D016015:Logistic Models; D016104:Oligohydramnios / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein
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