title: Anterior segment optical coherence tomography evaluation of corneal epithelium healing time after 2 different surface ablation methods.
abstract: OBJECTIVE
  To compare epithelial healing time following laser epithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) with anterior segment optic coherence tomography (AS-OCT).
  
  
  METHODS
  This prospective interventional case series study comprised 56 eyes of 28 patients that underwent laser refractive surgery in the Department of Ophthalmology, Medipol University Medical Faculty, Istanbul, Turkey, between March 2014 and May 2014. Each patient was randomized to have one eye operated on with PRK, and the other with LASEK. Patients were examined daily for 5 days, and epithelial healing time was assessed by using AS-OCT without removing therapeutic contact lens (TCL). Average discomfort scores were calculated from ratings obtained from questions regarding pain, photophobia, and lacrimation according to a scale of 0 (none) to 5.
  
  
  RESULTS
  The mean re-epithelialization time assessed with AS-OCT was 3.07±0.64 days in the PRK group, 3.55±0.54 days in the LASEK group, and the difference was statistically significant (p=0.03). Mean subjective discomfort score was 4.42±0.50 in the PRK eyes, and 2.85±0.44 in the LASEK eyes on the first exam day (p=0.001). The score obtained on the second (p=0.024), and third day (p=0.03) were also statistically significant. The fourth (p=0.069), and fifth days scores (p=0.1) showed no statistically significant difference between groups.
  
  
  CONCLUSIONS
  The PRK showed a statistically significant shorter epithelial healing time, but had a statistically significant higher discomfort score until the postoperative fourth day compared with LASEK.
authors: Department of Ophthalmology, Medipol Kosuyolu Hospital, Lambaci Sok Koşuyolu Kadiköy 34718, Istanbul, Turkey. Tel. +902 (16) 5446634. E-mail. drmustafaeliacik@gmail.com.
authors: Mustafa
authors: M
authors: Eliaçik
authors: Huseyin
authors: H
authors: Bayramlar
authors: Sevil K
authors: SK
authors: Erdur
authors: Yunus
authors: Y
authors: Karabela
authors: Goktug
authors: G
authors: Demirci
authors: Ibrahim G
authors: IG
authors: Gulkilik
authors: Mustafa
authors: M
authors: Ozsutcu
mesh_terms: D000293:Adolescent; D000328:Adult; D019573:Epithelium, Corneal / Q000502:physiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects; D008297:Male; D010149:Postoperative Pain; D018903:Photorefractive Keratectomy / Q000009:adverse effects; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014945:Wound Healing; D055815:Young Adult
references: J Refract Surg. 2014 Apr;30(4):256-64
references: 24702577
references: Ophthalmology. 2010 Oct;117(10):1912-22
references: 20709406
references: Nepal J Ophthalmol. 2010 Jul-Dec;2(2):97-104
references: 21505525
references: J Ophthalmol. 2014;2014:784185
references: 25120924
references: Br J Ophthalmol. 2008 Dec;92(12):1575-6
references: 19029159
references: Chin Med J (Engl). 2008 Nov 20;121(22):2331-5
references: 19080342
references: Cont Lens Anterior Eye. 2014 Dec;37(6):420-6
references: 25081522
references: J Refract Surg. 2011 Dec;27(12):887-93
references: 21877678
references: Korean J Ophthalmol. 2011 Apr;25(2):77-83
references: 21461218
references: J Cataract Refract Surg. 2011 Feb;37(2):335-40
references: 21241918
references: Open Ophthalmol J. 2011;5:51-4
references: 21686324
references: J Glaucoma. 2008 Sep;17(6):455-9
references: 18794679
references: J Refract Surg. 2008 Sep;24(7):671-84
references: 18811109
references: Biomed Opt Express. 2014 Mar 05;5(4):1089-98
references: 24761291
references: Curr Opin Ophthalmol. 2008 Mar;19(2):115-21
references: 18301284
references: Mol Med Rep. 2012 Jul;6(1):33-8
references: 22576735
references: Clin Exp Optom. 2014 Jan;97(1):12-7
references: 23656608
references: J Refract Surg. 2008 Jun;24(6):591-9
references: 18581784
references: J Ophthalmic Vis Res. 2010 Oct;5(4):223-7
references: 22737365