title: Diagnosis, management, and investigational therapies for food allergies.
abstract: Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods-2 major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.
authors: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: mike.kulis@unc.edu.
authors: Mike
authors: M
authors: Kulis
authors: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
authors: Benjamin L
authors: BL
authors: Wright
authors: Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas.
authors: Stacie M
authors: SM
authors: Jones
authors: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors: A Wesley
authors: AW
authors: Burks
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004032:Diet / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D011237:Predictive Value of Tests; D012307:Risk Factors; D063729:Sublingual Immunotherapy; D035703:Therapies, Investigational; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E
keywords: Food Allergy; Oral Immunotherapy; Prevalence; Sublingual Immunotherapy
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