title: Nanofibrous hydrogels with spatially patterned biochemical signals to control cell behavior.
abstract: The ability to spatially pattern biochemical signals into nanofibrous materials using thiol-ene reactions of thiolated molecules to presented norbornene groups is demonstrated. This approach is used to pattern three molecules independently within one scaffold, to pattern molecules through the depth of a scaffold, and to spatially control cell adhesion and morphology.
authors: Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors: Ryan J
authors: RJ
authors: Wade
authors: Ethan J
authors: EJ
authors: Bassin
authors: William M
authors: WM
authors: Gramlich
authors: Jason A
authors: JA
authors: Burdick
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006820:Hyaluronic Acid / Q000737:chemistry; D020100:Hydrogels; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D001643:Bridged Bicyclo Compounds; D020100:Hydrogels; C082069:bornylene; D006820:Hyaluronic Acid
keywords: alignment; electrospinning; nanofibers; patterning; tissue engineering
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