title: Micronuclei frequencies and nuclear abnormalities in oral exfoliated cells of nuclear power plant workers.
abstract: OBJECTIVE
  Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers.
  
  
  METHODS
  Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens (Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workers with absence of Leukemia and any malignancy (Group II) and workers diagnosed as leukemic patients and undergoing treatment (Group III).
  
  
  RESULTS
  There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in Leukemic Patients were significantly higher than those in exposed workers &control groups (p < 0.05).
  
  
  CONCLUSIONS
  MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is a need to educate those who work in NPS about the potential hazard of occupational exposure and the importance of using protective measures.
authors: Senior Lecturer, Department of Oral Pathology & Microbiology, Jodhpur Dental College General Hospital , Jodhpur, Rajasthan, India .
authors: Shitalkumar G
authors: SG
authors: Sagari
authors: Senior Lecturer, Department of Conservative Dentistry & Endodontics, Jodhpur Dental College General Hospital , Jodhpur, Rajasthan, India .
authors: Roopa
authors: R
authors: Babannavar
authors: Lecturer, Jodhpur School of Public Health, Jodhpur National University , Jodhpur, India .
authors: Abhishek
authors: A
authors: Lohra
authors: Senior Lecturer, Department of Prosthodontics, MIDSR Dental College and Hospital , Latur, Maharashtra, India .
authors: Ashwin
authors: A
authors: Kodgi
authors: Senior Lecturer, Department of Periodontics, MIDSR Dental College and Hospital , Latur, Maharashtra, India .
authors: Sunil
authors: S
authors: Bapure
authors: Senior Lecturer, Department of Prosthodontics, Maharana Pratap Dental College and Research Centre , Gwalior, India .
authors: Yogesh
authors: Y
authors: Rao
authors: Senior Lecturer, Department of Conservative Dentistry & Endodontics, Bapuji Dental College and Hospital , Davanagere, Karanataka, India .
authors: Arun
authors: A
authors: J
authors: Senior Lecturer, Department of Orthodontics, KLE VK institute of Dental Sciences , Belgaum, Karnataka, India .
authors: Manjunath
authors: M
authors: Malghan
keywords: DNA damage; Exfoliative cytology; Genotoxicity; Micronucleus
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