title: Mouse models of breast cancer.
abstract: Breast cancer is the most common cause of cancer death in women worldwide. This malignancy is a complex disease, which is defined by an intrinsic heterogeneity on the histopathological and molecular level as well as response to therapy and outcome. In addition to classical histopathological features, breast cancer can be categorized into at least five major subtypes based on comprehensive gene expression profiling: luminal A, luminal B, basal-like, ERBB2-positive, and normal-like breast cancer. Genetically engineered mouse models can serve as tools to study the molecular underpinnings for this disease. Given the genetic complexity that drives the initiation and progression of individual breast cancer subtypes, it is evident that certain models can reflect only particular aspects of this malignancy. In this book chapter, we will primarily focus on advances in modeling breast cancer at defined stages of carcinogenesis using genetically engineered mice. We will discuss the ability as well as shortcomings of these models to faithfully recapitulate the spectrum of human breast cancer subtypes.
authors: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE, 68198-5950, USA, ksakamoto@unmc.edu.
authors: Kazuhito
authors: K
authors: Sakamoto
authors: Jeffrey W
authors: JW
authors: Schmidt
authors: Kay-Uwe
authors: KU
authors: Wagner
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D055786:Gene Knockout Techniques; D005818:Genetic Engineering; D006801:Humans; D008024:Ligands; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis; D009857:Oncogenes / Q000235:genetics; D009928:Organ Specificity
chemical_list: D008024:Ligands
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