title: Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.
abstract: DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
authors: Università degli Studi di Milano (UniMI), Dip. Chimica, via Golgi 19, 20133, Milano, Italy. anna.bernardi@unimi.it.
authors: Stefania
authors: S
authors: Ordanini
authors: Norbert
authors: N
authors: Varga
authors: Vanessa
authors: V
authors: Porkolab
authors: Michel
authors: M
authors: Thépaut
authors: Laura
authors: L
authors: Belvisi
authors: Andrea
authors: A
authors: Bertaglia
authors: Alessandro
authors: A
authors: Palmioli
authors: Angela
authors: A
authors: Berzi
authors: Daria
authors: D
authors: Trabattoni
authors: Mario
authors: M
authors: Clerici
authors: Franck
authors: F
authors: Fieschi
authors: Anna
authors: A
authors: Bernardi
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000821:virology; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D002460:Cell Line; D002478:Cells, Cultured; D050091:Dendrimers / Q000737:chemistry* / Q000494:pharmacology*; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D008024:Ligands; D008358:Mannose / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D012709:Serum Albumin / Q000737:chemistry; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D050091:Dendrimers; D037181:Lectins, C-Type; D008024:Ligands; D008358:Mannose; D011956:Receptors, Cell Surface; D012709:Serum Albumin; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C023840:mannose-bovine serum albumin conjugate