title: DUBA-UBR5 axis: other than transactivation.
abstract: The genomic and transcriptomic analysis has led to the identification of transcriptional networks that affect the differentiation of Th17 cells, while the protein-protein networks and the posttranslational modifications that control the development of Th17 cells have not been established yet. A recent publication by Rutz et al. in Nature describes a novel deubiquitylating enzyme DUBA as a negative regulator for IL-17 by regulating stability of RORγt, the master transcription factor that induces Th17 cells.
authors: Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors: Chuan
authors: C
authors: Wu
authors: Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors: Zuojia
authors: Z
authors: Chen
authors: Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors: Vijay K
authors: VK
authors: Kuchroo
mesh_terms: D000818:Animals; D005260:Female; D020381:Interleukin-17 / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D058504:Th17 Cells / Q000378:metabolism*; D064570:Ubiquitin-Specific Proteases / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D064570:Ubiquitin-Specific Proteases
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