title: Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment.
abstract: Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo)plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.
authors: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
authors: Przemek A
authors: PA
authors: Gorski
authors: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
authors: Delaine K
authors: DK
authors: Ceholski
authors: Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA. Electronic address: roger.hajjar@mssm.edu.
authors: Roger J
authors: RJ
authors: Hajjar
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*
chemical_list: D000252:Calcium-Transporting ATPases; D002118:Calcium
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