title: Effect of menopausal status on carotid intima-media thickness and presence of carotid plaque in Chinese women generation population.
abstract: Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability of carotid plaque in Chinese female population is unclear. We conducted a population-based, cross-sectional study by recruiting 2,131 participants aged above 40 years from northeast of China. Carotid intima-media thickness (CIMT), presence of carotid plaque and its stability were evaluated by carotid duplex sonography. Among the participants, 1,133 (53.2%) were identified to be postmenopausal. After adjusting for potential confounding factors, presence of CIMT at 50(th-) 75(th) and ≥75(th) percentiles, carotid plaque and its unstable status were found to be significantly associated with the postmenopausal status (P < 0.001). When matched the participants by age, post-menopausal status was still associated with a higher risk of having unstable plaque. Moreover, our data show that postmenopausal status is a risk factor for intracranial arterial stenosis when compared with premenopausal status in the univariate analysis (OR = 1.314, P = 0.043), and such relationship is lost when the confounding factors are adjusted (OR = 0.828, P = 0.225). In conclusion, the vascular risk factors increase as the menopausal status changes. Compared with premenopausal status, postmenopausal status is associated with higher morbidity of CIMT, carotid plaque and its unstable status.
authors: 1] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2] China National Clinical Research Center for Neurological Diseases, Beijing, China [3] Center of Stroke, Beijing Institute for Brain Disorders [4] Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease.
authors: Yong
authors: Y
authors: Zhou
authors: 1] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2] China National Clinical Research Center for Neurological Diseases, Beijing, China [3] Center of Stroke, Beijing Institute for Brain Disorders [4] Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease.
authors: Dandan
authors: D
authors: Wang
authors: Department of General Practice, School of General Practice and Continuing Education, Capital Medical University, Beijing, China.
authors: Xin
authors: X
authors: Yang
authors: 1] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2] China National Clinical Research Center for Neurological Diseases, Beijing, China [3] Center of Stroke, Beijing Institute for Brain Disorders [4] Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease.
authors: Anxin
authors: A
authors: Wang
authors: 1] Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA [2] Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA.
authors: Xiang
authors: X
authors: Gao
authors: Division of Epidemiology and Biostatistics, School of Population Health, University of Queensland, Brisbane, Australia.
authors: Yuming
authors: Y
authors: Guo
authors: Department of Cardiology, Kailuan Hospital, Tangshan, China.
authors: Shouling
authors: S
authors: Wu
authors: 1] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2] China National Clinical Research Center for Neurological Diseases, Beijing, China [3] Center of Stroke, Beijing Institute for Brain Disorders [4] Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease.
authors: Xingquan
authors: X
authors: Zhao
mesh_terms: D000328:Adult; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000209:etiology; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D058226:Plaque, Atherosclerotic / Q000503:physiopathology*; D017698:Postmenopause; D017697:Premenopause; D012307:Risk Factors
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