title: Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.
abstract: The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional antibiotics. Attractive possibilities include pro- and anti-quorum sensing therapies that function by modulating bacterial chemical communication circuits. We report the use of Flash NanoPrecipitation to deliver the Vibrio cholerae quorum-sensing signal CAI-1 ((S)-3-hydroxytridecan-4-one) in a water dispersible form as nanoparticles. The particles activate V. cholerae quorum-sensing responses 5 orders of magnitude higher than does the identically administered free CAI-1 and are diffusive across in vivo delivery barriers such as intestinal mucus. This work highlights the promise of combining quorum-sensing strategies with drug delivery approaches for the development of next-generation medicines.
authors: Hoang D
authors: HD
authors: Lu
authors: Alina C
authors: AC
authors: Spiegel
authors: Amanda
authors: A
authors: Hurley
authors: ∥Department of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028, United States.
authors: Lark J
authors: LJ
authors: Perez
authors: Katharina
authors: K
authors: Maisel
authors: Laura M
authors: LM
authors: Ensign
authors: Justin
authors: J
authors: Hanes
authors: ○Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.
authors: Bonnie L
authors: BL
authors: Bassler
authors: Martin F
authors: MF
authors: Semmelhack
authors: Robert K
authors: RK
authors: Prud'homme
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development*; D007659:Ketones / Q000008:administration & dosage* / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D053038:Quorum Sensing / Q000187:drug effects* / Q000502:physiology*
chemical_list: C525620:3-hydroxytridecan-4-one; D007659:Ketones; D053769:Nanocapsules
keywords: CAI-1; Nanoparticle; Vibrio cholerae; autoinducer; drug delivery; quorum sensing
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