title: Moving targets: Emerging roles for MMPs in cancer progression and metastasis.
abstract: Matrix metalloproteinases have long been associated with cancer. Clinical trials of small molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a variety of tumor types. Here, we discuss some of the newer roles that have been uncovered for MMPs in cancer that would not have been targeted with those initial inhibitors or in the patient populations analyzed. We also consider novel ways of using cancer-associated MMP activity for clinical benefit.
authors: Dept. of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
authors: Gemma
authors: G
authors: Shay
authors: Dept. of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
authors: Conor C
authors: CC
authors: Lynch
authors: Dept of Cancer Biology, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA. Electronic address: Barbara.fingleton@vanderbilt.edu.
authors: Barbara
authors: B
authors: Fingleton
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D020782:Matrix Metalloproteinases / Q000187:drug effects / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*
chemical_list: D020782:Matrix Metalloproteinases
keywords: Activity-based probe; Efficacy; Imaging; Non-catalytic; Pre-metastatic niche; Theranostic; Therapy
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