title: Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort.
abstract: DNA variants at the genes that encode components of the IL17-pathway may contribute to the risk of impaired renal function/chronic kidney disease. Our aim was to determine whether common IL17RA single nucleotide polymorphisms (SNPs) were associated with a reduced estimated glomerular filtration rate (eGFR) in a cohort of healthy elderly individuals (n=650). We found a significantly higher frequency of SNP rs4819554 AA homozygotes among individuals with eGFR<60 ml/min/1.73 m(2) (n=90) (p=0.005, OR=2.11; 1.26-3.54), an effect that was independent of the presence of type 2 diabetes. Allele rs4819554 A had been associated to the risk of developing end stage renal disease, and was also linked to an increased expression of the IL17RA protein and higher levels of Th17 cell subsets. A scenario in which the pro-inflammatory role of the IL17-pathway contributes to kidney damage might explain the association between Il17RA polymorphisms and an impaired renal function.
authors: Genética Molecular-Laboratorio Medicina, HUCA, Oviedo, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain; Fundación Renal I. Alvarez de Toledo, Madrid, Spain. Electronic address: eliecer.coto@sespa.es.
authors: Eliecer
authors: E
authors: Coto
authors: Genética Molecular-Laboratorio Medicina, HUCA, Oviedo, Spain.
authors: Juan
authors: J
authors: Gómez
authors: Laboratorio de Biología Celular de la Enfermedad Renal, Instituto de Investigacion Sanitaria F. Jiménez Diaz, Universidad Autónoma Madrid, Madrid, Spain.
authors: Beatriz
authors: B
authors: Suárez
authors: Centro de Salud El Cristo, Oviedo, Spain.
authors: Salvador
authors: S
authors: Tranche
authors: Nefrología, HUCA, Oviedo, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain; Fundación Renal I. Alvarez de Toledo, Madrid, Spain.
authors: Carmen
authors: C
authors: Díaz-Corte
authors: Unidad de diálisis, Instituto de Investigacion Sanitaria F. Jiménez Diaz, Universidad Autónoma Madrid, Madrid, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain.
authors: Alberto
authors: A
authors: Ortiz
authors: Laboratorio de Biología Celular de la Enfermedad Renal, Instituto de Investigacion Sanitaria F. Jiménez Diaz, Universidad Autónoma Madrid, Madrid, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain.
authors: Marta
authors: M
authors: Ruiz-Ortega
authors: Dermatología, HUCA, Oviedo, Spain.
authors: Pablo
authors: P
authors: Coto-Segura
authors: Dermatología, HUCA, Oviedo, Spain.
authors: Ana
authors: A
authors: Batalla
authors: Inmunología, HUCA, Oviedo, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain; Fundación Renal I. Alvarez de Toledo, Madrid, Spain.
authors: Carlos
authors: C
authors: López-Larrea
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005919:Glomerular Filtration Rate / Q000235:genetics; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053722:Receptors, Interleukin-17 / Q000235:genetics*; D013030:Spain; D058504:Th17 Cells / Q000276:immunology*
chemical_list: C109985:IL17RA protein, human; D018836:Inflammation Mediators; D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Gene polymorphism; Glomerular filtration; IL17 pathway genes; Renal function