title: Preventing bacterial growth on implanted device with an interfacial metallic film and penetrating X-rays.
abstract: Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as a radio-sensitizing film for bacterial inhibition. At a given dose of X-ray, the bacterial viability decreases as the thickness of metal film (bismuth) increases. The bacterial viability decreases with X-ray dose increases. At X-ray dose of 2.5 Gy, 98% of bacteria on 10 nm thick bismuth film are killed; while it is only 25% of bacteria are killed on the bare petri dish. The same dose of X-ray kills 8% fibroblast cells that are within a short distance from bismuth film (4 mm). These results suggest that penetrating X-rays can kill bacteria on bismuth thin film deposited on surface of implant device efficiently.
authors: Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, 01609, USA.
authors: Jincui
authors: J
authors: An
authors: An
authors: A
authors: Sun
authors: Yong
authors: Y
authors: Qiao
authors: Peipei
authors: P
authors: Zhang
authors: Ming
authors: M
authors: Su
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D001729:Bismuth / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D049109:Cell Proliferation / Q000502:physiology / Q000528:radiation effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000528:radiation effects; D019736:Prostheses and Implants / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development* / Q000528:radiation effects; D013242:Sterilization / Q000379:methods*; D014965:X-Rays
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D001729:Bismuth
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