title: Multi-platform Genome-wide Analysis of Melanoma Progression to Brain Metastasis.
abstract: Melanoma has a high tendency to metastasize to brain tissue. The understanding about the molecular alterations of early-stage melanoma progression to brain metastasis (MBM) is very limited. Identifying MBM-specific genomic and epigenomic alterations is a key initial step in understanding its aggressive nature and identifying specific novel druggable targets. Here we describe a multi-platform dataset generated with different stages of melanoma progression to MBM. This data includes genome-wide DNA methylation (Illumina HM450K BeadChip), gene expression (Affymetrix HuEx 1.0 ST array), single nucleotide polymorphisms (SNPs) and copy number variation (CNV; Affymetrix SNP 6.0 array) analyses of melanocyte cells (MNCs), primary melanoma tumors (PRMs), lymph node metastases (LNMs) and MBMs. The analysis of this data has been reported in our recently published study (Marzese et al., 2014).
authors: Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
authors: Diego M
authors: DM
authors: Marzese
authors: Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
authors: Jamie L
authors: JL
authors: Huynh
authors: Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
authors: Neal P
authors: NP
authors: Kawas
authors: Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.
authors: Dave S B
authors: DS
authors: Hoon
keywords: Brain Metastasis; Cancer Progression; Expression Array; HM450K; Melanoma; SNP array
references: Hum Mol Genet. 2014 Jan 1;23(1):226-38
references: 24014427