title: F-18 fluorodeoxyglucose positron emission tomography study of impaired emotion processing in first episode schizophrenia.
abstract: BACKGROUND
  Schizophrenia cases have been consistently shown to have behavioural and neurofunctional abnormalities but studies during early course are scarce. The present work assesses the performance of acute first episode schizophrenia cases on correlation of a facial emotion perception task with brain function using fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET).
  
  
  METHODS
  Twenty First episode schizophrenia cases and 20 matched healthy controls living in the community were enrolled. For cases, longest duration of illness was one year and treatment with neuroleptic did not exceed two weeks on the day of scan. To measure facial emotion perception (FEP) both groups were administered the Emotion battery from the Penn Computerized Battery followed by PET acquisition. SPM 8 analysis for group differences at p<0.001 was performed.
  
  
  RESULTS
  Schizophrenia subjects showed hypoactivation of bilateral prefrontal cortices and fusiform gyrii, with significant hyperactivation of bilateral basal ganglia and left precuneus. Positive correlation of metabolism in prefrontal cortex and performance indices on emotions domain was seen. No correlation of chlorpromazine equivalent days with metabolism in basal ganglia was observed.
  
  
  CONCLUSIONS
  The performance of schizophrenia cases on FEP task was significantly impaired in comparison to the control group. Brain regions implicated in emotion processing showed hypometabolism in cases as compared to controls. Failure of schizophrenia cases to optimally recruit brain circuitry may be contributing to deficits on FEP task. These findings suggest inherent deficits in neural circuitry of emotion processing in schizophrenia; devoid of confounding effects of neuroleptics and duration of illness.
authors: Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India.
authors: Mona
authors: M
authors: Choudhary
authors: Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India.
authors: Arvind
authors: A
authors: Kumar
authors: Institute of Nuclear Medicine and Allied Sciences, Timarpur, New Delhi, India.
authors: Madhavi
authors: M
authors: Tripathi
authors: Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India.
authors: Triptish
authors: T
authors: Bhatia
authors: Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Center, National Institute of Mental Health and Neuro Science, Bangaluru, India.
authors: Venkataram
authors: V
authors: Shivakumar
authors: Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India.
authors: Ram Pratap
authors: RP
authors: Beniwal
authors: Schizophrenia Research Centre, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.
authors: Ruben C
authors: RC
authors: Gur
authors: Schizophrenia Research Centre, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.
authors: Raquel E
authors: RE
authors: Gur
authors: Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA; Department of Human Genetics, University of Pittsburgh, Pittsburgh, USA.
authors: Vishwajit L
authors: VL
authors: Nimgaonkar
authors: Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India. Electronic address: indusszgenes@gmail.com.
authors: Smita N
authors: SN
authors: Deshpande
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D004644:Emotions; D005149:Facial Expression; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG; Facial emotion perception; First episode schizophrenia; Neuroleptic; PET; SPM
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