title: The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans.
abstract: The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the "natural" VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the "natural" VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the "normal" vestibular system.
authors: Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Center Maastricht, Netherlands ; Faculty of Physics, Tomsk State University Tomsk, Russia.
authors: Raymond
authors: R
authors: van de Berg
authors: Service of Otorhinolaryngology and Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals Geneva, Switzerland.
authors: Nils
authors: N
authors: Guinand
authors: Translational Neural Engineering Lab, Center for Neuroprosthetics, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne Lausanne, Switzerland.
authors: T A Khoa
authors: TA
authors: Nguyen
authors: Service of Otorhinolaryngology and Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals Geneva, Switzerland.
authors: Maurizio
authors: M
authors: Ranieri
authors: Service of Otorhinolaryngology and Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals Geneva, Switzerland.
authors: Samuel
authors: S
authors: Cavuscens
authors: Service of Otorhinolaryngology and Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals Geneva, Switzerland.
authors: Jean-Philippe
authors: JP
authors: Guyot
authors: Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Center Maastricht, Netherlands.
authors: Robert
authors: R
authors: Stokroos
authors: Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Center Maastricht, Netherlands ; Faculty of Physics, Tomsk State University Tomsk, Russia.
authors: Herman
authors: H
authors: Kingma
authors: Service of Otorhinolaryngology and Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals Geneva, Switzerland.
authors: Angelica
authors: A
authors: Perez-Fornos
keywords: bilateral vestibular areflexia; bilateral vestibulopathy; neural prosthesis; vestibular implant; vestibular prosthesis; vestibulo-ocular reflex
references: IEEE Trans Neural Syst Rehabil Eng. 2011 Feb;19(1):84-94
references: 20813652
references: J Vestib Res. 2012;22(5-6):283-98
references: 23302709
references: Front Neurol. 2011 Dec 27;2:88
references: 22207864
references: Otol Neurotol. 2009 Aug;30(5):586-91
references: 19574943
references: J Neurophysiol. 2010 Feb;103(2):1066-79
references: 20018838
references: IEEE Trans Biomed Eng. 2002 Feb;49(2):175-81
references: 12066886
references: J Vestib Res. 1995 Mar-Apr;5(2):67-107
references: 7743004
references: Exp Brain Res. 2011 May;210(3-4):595-606
references: 21374081
references: Ann Otol Rhinol Laryngol. 1989 Aug;98(8 Pt 1):625-9
references: 2764446
references: Front Neurol. 2014 Apr 29;5:66
references: 24808890
references: Front Neurol. 2011 Aug 11;2:47
references: 21991260
references: J Comput Neurosci. 1999 Jul-Aug;7(1):55-70
references: 10482002
references: Hear Res. 2011 Nov;281(1-2):74-83
references: 21888961
references: IEEE Trans Biomed Eng. 2007 Jun;54(6 Pt 1):1005-15
references: 17554820
references: J Assoc Res Otolaryngol. 2013 Dec;14(6):863-77
references: 24013822
references: Hear Res. 2012 May;287(1-2):51-6
references: 22504025
references: Ann N Y Acad Sci. 1981;374:330-9
references: 6978633
references: Restor Neurol Neurosci. 2010;28(1):69-82
references: 20086284
references: Front Neurol. 2012 Feb 20;3:18
references: 22363317
references: J Neurol Neurosurg Psychiatry. 2008 Mar;79(3):284-8
references: 17635972
references: Exp Brain Res. 2011 May;210(3-4):643-9
references: 21369854
references: JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):803-10
references: 23949355
references: Exp Brain Res. 1981;41(2):108-14
references: 6970677
references: J Neurophysiol. 1984 Jun;51(6):1236-56
references: 6737029
references: Exp Brain Res. 2011 May;210(3-4):489-501
references: 21190017
references: Neuroreport. 1997 Aug 18;8(12):2755-9
references: 9295113
references: Ann Otol Rhinol Laryngol. 2012 Jul;121(7):471-7
references: 22844867
references: Otol Neurotol. 2014 Jan;35(1):136-47
references: 24317220
references: Otol Neurotol. 2012 Jul;33(5):789-96
references: 22699989
references: Aviat Space Environ Med. 1981 Feb;52(2):73-7
references: 6971094
references: Ann N Y Acad Sci. 2009 May;1164:331-3
references: 19645921
references: J Assoc Res Otolaryngol. 2010 Sep;11(3):367-81
references: 20177732
references: Neurology. 2008 Nov 25;71(22):1776-82
references: 19029517
references: Exp Brain Res. 2002 Jan;142(2):259-67
references: 11807579
references: J Assoc Res Otolaryngol. 2013 Apr;14(2):233-48
references: 23355001
references: Ann Otol Rhinol Laryngol. 2011 Mar;120(3):143-9
references: 21510138
references: Exp Brain Res. 2011 May;210(3-4):623-40
references: 21380738
references: IEEE Trans Biomed Eng. 2007 Jun;54(6 Pt 1):1016-30
references: 17554821
references: J Assoc Res Otolaryngol. 2013 Jun;14(3):331-40
references: 23423561
references: Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3126-9
references: 24110390
references: Am J Otol. 1996 May;17(3):401-9
references: 8817017
references: Ann Otol Rhinol Laryngol. 2007 May;116(5):369-74
references: 17561766
references: J Neurophysiol. 2007 Feb;97(2):1503-14
references: 17122313
references: Ann Otol Rhinol Laryngol. 1989 Jul;98(7 Pt 1):548-50
references: 2751213
references: Semin Neurol. 2013 Jul;33(3):195-203
references: 24057822
references: Brain Res. 1974 Jan 4;65(1):170-4
references: 4810171
references: Exp Brain Res. 2012 May;218(3):389-400
references: 22349559
references: Hear Res. 2011 Jul;277(1-2):204-10
references: 21195755
references: J Vestib Res. 2002-2003;12(2-3):87-94
references: 12867667
references: IEEE Trans Biomed Eng. 2006 Nov;53(11):2362-72
references: 17073343
references: J Neurophysiol. 1997 Oct;78(4):2129-44
references: 9325380
references: Prog Neurobiol. 1993 Oct;41(4):435-72
references: 8210413
references: J Vestib Res. 2002-2003;12(2-3):95-113
references: 12867668