title: Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.
abstract: Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.
authors: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
authors: Md Ashraful
authors: 0000-0001-7596-5868
authors: MA
authors: Alam
authors: Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217, Bangladesh.
authors: Riaz
authors: 0000-0001-8133-9732
authors: R
authors: Uddin
authors: School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
authors: Nusrat
authors: N
authors: Subhan
authors: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
authors: Md Mahbubur
authors: MM
authors: Rahman
authors: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
authors: Preeti
authors: P
authors: Jain
authors: Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh.
authors: Hasan Mahmud
authors: HM
authors: Reza
references: Curr Opin Lipidol. 2009 Apr;20(2):98-105
references: 19276888
references: Obesity (Silver Spring). 2006 Jul;14(7):1118-23
references: 16899792
references: Molecules. 2012 Aug 10;17(8):9631-40
references: 22885359
references: J Ethnopharmacol. 2007 May 30;112(1):77-84
references: 17363205
references: Mol Cell Biol. 2000 Mar;20(5):1868-76
references: 10669761
references: Physiol Rev. 2010 Jan;90(1):23-46
references: 20086073
references: J Agric Food Chem. 2013 Mar 13;61(10):2461-8
references: 23414136
references: Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E145-61
references: 20371735
references: J Med Food. 2010 Jun;13(3):520-7
references: 20521977
references: J Agric Food Chem. 2010 Feb 10;58(3):1518-22
references: 20070086
references: Biol Pharm Bull. 2006 Jun;29(6):1126-31
references: 16755004
references: Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1545-50
references: 17077551
references: Magn Reson Chem. 2007 Jun;45(6):451-6
references: 17431862
references: Exp Gerontol. 2008 Sep;43(9):813-9
references: 18662766
references: J Clin Endocrinol Metab. 2008 Apr;93(4):1433-41
references: 18211970
references: J Nutr. 2011 Sep;141(9):1664-72
references: 21813810
references: Diabetes Res Clin Pract. 1998 Jun;40(3):145-51
references: 9716917
references: Nat Med. 2005 Feb;11(2):191-8
references: 15685170
references: Indian J Exp Biol. 2007 Dec;45(12):1055-62
references: 18254212
references: Ann N Y Acad Sci. 2010 Mar;1190:15-24
references: 20388133
references: Evid Based Complement Alternat Med. 2011;2011:952031
references: 21799697
references: Cell Metab. 2009 May;9(5):407-16
references: 19416711
references: Food Chem Toxicol. 2010 Jun;48(6):1619-26
references: 20347917
references: Mol Cell Biochem. 2004 Jun;261(1-2):99-104
references: 15362491
references: PLoS One. 2013 Oct 08;8(10):e75334
references: 24116036
references: Biosci Biotechnol Biochem. 2007 Mar;71(3):735-40
references: 17341830
references: Diabetologia. 2005 Nov;48(11):2354-64
references: 16237515
references: Br J Nutr. 2009 Dec;102(12):1703-8
references: 19825210
references: Diabetes Res Clin Pract. 2008 Aug;81(2):134-43
references: 18550200
references: Mol Cell Biol. 2009 Sep;29(17):4714-28
references: 19564408
references: J Biol Chem. 2004 Jun 25;279(26):27177-86
references: 15105415
references: Nutr Res. 2013 Jul;33(7):580-5
references: 23827133
references: Phytother Res. 2004 Nov;18(11):954-6
references: 15597317
references: Atherosclerosis. 2006 Mar;185(1):21-31
references: 16002078
references: Br J Nutr. 2008 May;99(5):931-40
references: 17977473
references: Int J Obes (Lond). 2008 Sep;32 Suppl 4:S7-12
references: 18719601
references: J Cardiovasc Pharmacol. 2011 Jan;57(1):51-64
references: 20966763
references: Adv Nutr. 2012 Jul 01;3(4):491-8
references: 22797984
references: Phytother Res. 2014 Mar;28(3):363-71
references: 23610006
references: Cell Res. 2008 Nov;18(11):1087-95
references: 18825165
references: Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1017-21
references: 16819222
references: Gastroenterology. 2007 May;132(6):2169-80
references: 17498510
references: J Nutr. 2003 Apr;133(4):1088-93
references: 12672924
references: J Ethnopharmacol. 2005 Dec 1;102(3):326-35
references: 16095853
references: Br J Nutr. 2008 Feb;99(2):230-9
references: 17651527
references: J Med Food. 2012 Feb;15(2):101-7
references: 22191631
references: J Ethnopharmacol. 2009 Dec 10;126(3):533-7
references: 19744549
references: Chem Pharm Bull (Tokyo). 2001 Jan;49(1):54-63
references: 11201226
references: Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):150-9
references: 19229235
references: J Biol Chem. 2002 Jan 4;277(1):793-803
references: 11598116
references: J Biol Chem. 1996 Mar 22;271(12):7128-33
references: 8636148
references: Phytomedicine. 2011 Dec 15;19(1):32-7
references: 22133295
references: BMC Public Health. 2009 Mar 25;9:88
references: 19320986
references: Mol Cell Biochem. 2009 Jul;327(1-2):247-56
references: 19238523
references: Nutr Rev. 2006 Jul;64(7 Pt 1):331-7
references: 16910221
references: Phytomedicine. 1996 Mar;2(4):349-62
references: 23194773
references: Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1039-44
references: 11052958
references: Cochrane Database Syst Rev. 2012 Aug 15;(8):CD007845
references: 22895968
references: Free Radic Biol Med. 2008 Apr 1;44(7):1259-72
references: 18242193
references: J Med Food. 2011 Jan-Feb;14(1-2):86-93
references: 21128828
references: Biol Pharm Bull. 2004 Feb;27(2):216-8
references: 14758036
references: J Cardiovasc Pharmacol. 2011 May;57(5):611-24
references: 21572266
references: Curr Opin Pharmacol. 2005 Apr;5(2):177-83
references: 15780828
references: Food Chem. 2008 Oct 15;110(4):881-90
references: 26047274
references: Gene. 1995 Aug 19;161(2):151-6
references: 7665070
references: Evid Based Complement Alternat Med. 2011;2011:612023
references: 20047891
references: Molecules. 2009 Nov 25;14(12):4804-13
references: 20032860
references: Diabetes. 1994 Nov;43(11):1271-8
references: 7926300
references: J Clin Invest. 2006 Mar;116(3):615-22
references: 16511594
references: Biochem Biophys Res Commun. 2007 Aug 3;359(3):419-25
references: 17548058
references: Mol Cell Biol. 2009 Jul;29(13):3544-55
references: 19414603
references: J Nutr. 2012 Jul;142(7):1197-204
references: 22623391
references: Indian J Physiol Pharmacol. 2004 Apr;48(2):241-4
references: 15521566
references: J Physiol. 2003 Feb 1;546(Pt 3):851-8
references: 12563009
references: Nature. 2008 Jul 24;454(7203):470-7
references: 18650918
references: Maturitas. 2011 May;69(1):41-9
references: 21466928
references: J Nutr. 2005 Nov;135(11):2517-23
references: 16251604
references: J Nat Prod. 2008 Aug;71(8):1327-30
references: 18637688
references: J Clin Invest. 2003 Dec;112(12):1796-808
references: 14679176
references: Endocr Rev. 2003 Feb;24(1):78-90
references: 12588810
references: Obes Rev. 2010 Jan;11(1):11-8
references: 19656312
references: Planta Med. 1993 Oct;59(5):408-12
references: 8255932
references: J Ethnopharmacol. 2009 May 4;123(1):82-90
references: 19429344
references: Planta Med. 2008 Aug;74(10):1291-4
references: 18622906
references: J Ethnopharmacol. 2004 Jul;93(1):123-32
references: 15182917
references: Am J Clin Nutr. 2005 Jan;81(1):122-9
references: 15640470
references: J Hepatol. 2010 Nov;53(5):934-40
references: 20675007
references: Nat Prod Res. 2011 Feb;25(4):353-67
references: 21328131
references: Br J Nutr. 2005 May;93(5):747-54
references: 15975176
references: Immunol Cell Biol. 2007 Aug-Sep;85(6):399-400
references: 17646847
references: Diabetes. 2001 Jan;50(1):123-30
references: 11147777
references: Nutr J. 2012 Jan 13;11:4
references: 22243626
references: Int J Obes (Lond). 2008 Sep;32(9):1431-7
references: 18607383
references: Br J Nutr. 2008 Apr;99(4):806-12
references: 17942003
references: Mol Cell Biochem. 2004 Jun;261(1-2):63-70
references: 15362486
references: Diabetologia. 2010 Dec;53(12):2496-503
references: 20830466
references: J Nat Prod. 2007 Aug;70(8):1233-9
references: 17685651
references: BMC Complement Altern Med. 2010 Jun 29;10 :34
references: 20587058
references: J Hepatol. 2010 Nov;53(5):795-6
references: 20800308
references: Ann N Y Acad Sci. 2004 Nov;1033:1-16
references: 15590999
references: J Gerontol A Biol Sci Med Sci. 2005 Dec;60(12):1494-509
references: 16424281
references: Nat Med. 2005 Feb;11(2):183-90
references: 15685173
references: Magn Reson Chem. 2010 May;48(5):392-6
references: 20225243
references: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15983-7
references: 12444247
references: Endocrinology. 2008 Apr;149(4):2019-26
references: 18162524
references: Phytochemistry. 2009 Jan;70(1):133-40
references: 19041990
references: Endocrinol Metab Clin North Am. 2006 Sep;35(3):491-510, vii-viii
references: 16959582
references: J Biol Chem. 2008 Dec 19;283(51):35724-34
references: 18838377
references: Cell. 1998 May 29;93(5):693-704
references: 9630215
references: Bangladesh Med Res Counc Bull. 1999 Apr;25(1):11-3
references: 10758656
references: Diabetes Res Clin Pract. 2001 Mar;51(3):155-61
references: 11269887
references: J Am Diet Assoc. 2011 Aug;111(8):1137-40
references: 21802558
references: J Ethnopharmacol. 2011 Mar 24;134(2):422-8
references: 21211558
references: Planta Med. 2010 Oct;76(15):1758-61
references: 20379957
references: J Exp Biol. 2002 Aug;205(Pt 15):2275-85
references: 12110661
references: Lancet. 2011 Feb 12;377(9765):557-67
references: 21295846
references: J Ethnopharmacol. 2000 Sep;72(1-2):331-6
references: 10967491
references: J Ethnopharmacol. 2003 Sep;88(1):107-11
references: 12902059
references: J Clin Epidemiol. 2007 Jun;60(6):554-9
references: 17493509
references: Cell. 2006 Dec 15;127(6):1109-22
references: 17112576
references: Annu Rev Physiol. 2009;71:177-203
references: 19575678
references: J Med Food. 2011 Dec;14(12):1496-504
references: 21861717
references: Biol Pharm Bull. 2005 Jun;28(6):978-83
references: 15930730
references: Planta Med. 1990 Oct;56(5):426-9
references: 2077547
references: J Agric Food Chem. 2010 Apr 14;58(7):4428-33
references: 20225855
references: J Nutr Sci Vitaminol (Tokyo). 2001 Oct;47(5):340-4
references: 11814149
references: J Nat Prod. 2005 May;68(5):807-9
references: 15921438
references: Br J Nutr. 2008 Oct;100(4):751-9
references: 18321395
references: J Nat Prod. 2006 Aug;69(8):1168-71
references: 16933869
references: Pharmacol Res. 1996 Jan;33(1):1-4
references: 8817639
references: Diabetes. 2009 Mar;58(3):550-8
references: 19073774
references: Trends Endocrinol Metab. 2011 Aug;22(8):333-43
references: 21646028
references: Cardiovasc J S Afr. 2006 Sep-Oct;17(5):227-32
references: 17117226
references: IUBMB Life. 2009 Nov;61(11):1051-62
references: 19859975
references: Sci Rep. 2013 Nov 05;3:3142
references: 24189525