title: Surround suppression and temporal processing of visual signals.
abstract: Extraclassical surround suppression strongly modulates responses of neurons in the retina, lateral geniculate nucleus (LGN), and primary visual cortex. Although a great deal is known about the spatial properties of extraclassical suppression and the role it serves in stimulus size tuning, relatively little is known about how extraclassical suppression shapes visual processing in the temporal domain. We recorded the spiking activity of retinal ganglion cells and LGN neurons in the cat to test the hypothesis that extraclassical suppression influences temporal features of visual responses in the early visual system. Our results demonstrate that extraclassical suppression not only shifts the distribution of interspike intervals in a manner that decreases the efficacy of neuronal communication, it also decreases the reliability of neuronal responses to visual stimuli and it decreases the duration of visual responses, an effect that underlies a rightward shift in the temporal frequency tuning of LGN neurons. Taken together, these results reveal a dynamic relationship between extraclassical suppression and the temporal features of neuronal responses.
authors: Center for Neuroscience, University of California-Davis, Davis, California; Department of Neurobiology, Physiology, and Behavior, University of California-Davis, Davis, California; and.
authors: Henry J
authors: HJ
authors: Alitto
authors: Center for Neuroscience, University of California-Davis, Davis, California; Department of Neurobiology, Physiology, and Behavior, University of California-Davis, Davis, California; and Department of Neurology, University of California-Davis, Sacramento, California wmusrey@ucdavis.edu.
authors: W Martin
authors: WM
authors: Usrey
mesh_terms: D000200:Action Potentials; D000818:Animals; D002415:Cats; D015350:Contrast Sensitivity / Q000502:physiology; D005260:Female; D005829:Geniculate Bodies / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D012165:Retinal Ganglion Cells / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*
keywords: cat; extraclassical suppression; lateral geniculate nucleus; nonlinear receptive field
references: Exp Brain Res. 1981;41(3-4):414-9
references: 7215502
references: Nature. 1998 Sep 24;395(6700):384-7
references: 9759728
references: J Neurophysiol. 1999 Dec;82(6):3527-40
references: 10601479
references: Neuron. 1999 Aug;23(4):765-73
references: 10482242
references: Exp Brain Res. 1986;63(1):1-20
references: 3015651
references: Vision Res. 1987;27(5):765-80
references: 3660638
references: Neuron. 2008 Jan 10;57(1):135-46
references: 18184570
references: Nat Neurosci. 1999 Aug;2(8):733-9
references: 10412063
references: J Neurosci. 2009 Apr 15;29(15):5009-21
references: 19369570
references: J Neurosci. 2000 Jul 15;20(14):5461-7
references: 10884329
references: Nature. 2008 Nov 20;456(7220):391-4
references: 18849967
references: Vis Neurosci. 2003 May-Jun;20(3):221-30
references: 14570244
references: Nature. 2012 Mar 1;483(7387):47-52
references: 22367547
references: Vis Neurosci. 1999 Sep-Oct;16(5):943-56
references: 10580730
references: J Neurophysiol. 1995 Dec;74(6):2548-57
references: 8747213
references: J Comp Neurol. 2006 Sep 20;498(3):330-51
references: 16871526
references: Vis Neurosci. 1999 Mar-Apr;16(2):355-68
references: 10367969
references: Vision Res. 1983;23(8):775-85
references: 6623937
references: Prog Brain Res. 2004;145:179-96
references: 14650916
references: J Physiol. 1978 Dec;285:275-98
references: 745079
references: J Neurophysiol. 2005 Sep;94(3):1789-97
references: 15888523
references: Neuron. 2008 May 22;58(4):625-38
references: 18498742
references: J Neurophysiol. 2004 Jun;91(6):2797-808
references: 14762157
references: J Neurophysiol. 1981 Jan;45(1):107-20
references: 6259298
references: Vision Res. 1979;19(4):431-4
references: 473613
references: J Neurophysiol. 2010 Oct;104(4):1884-98
references: 20685925
references: J Comp Neurol. 1987 May 1;259(1):92-121
references: 2884241
references: J Neurophysiol. 2002 Nov;88(5):2530-46
references: 12424292
references: Neuron. 2008 Feb 28;57(4):482-97
references: 18304479
references: J Neurophysiol. 2007 Aug;98(2):769-85
references: 17553944
references: J Neurosci. 2003 Aug 20;23(20):7690-701
references: 12930809
references: J Neurosci. 2006 Aug 23;26(34):8715-26
references: 16928860
references: J Neurophysiol. 2001 May;85(5):1873-87
references: 11353004
references: Nat New Biol. 1971 Jun 9;231(23):191-2
references: 4325715
references: Neuroscience. 2007 Nov 23;149(4):962-75
references: 17945429
references: J Neurosci. 2013 May 8;33(19):8504-17
references: 23658187
references: Vision Res. 1994 Dec;34(23):3081-96
references: 7975341
references: Nat Neurosci. 2010 Mar;13(3):369-78
references: 20173745
references: J Neurosci. 2001 Mar 15;21(6):2104-12
references: 11245694
references: J Neurosci. 2004 Feb 11;24(6):1428-38
references: 14960615
references: J Neurophysiol. 2006 Dec;96(6):3474-84
references: 16928793
references: Front Integr Neurosci. 2012 Dec 24;6:118
references: 23269915
references: Vis Neurosci. 2007 Sep-Oct;24(5):679-90
references: 17686200
references: J Neurophysiol. 2013 Feb;109(3):889-99
references: 23100142
references: J Neurosci. 2012 Jul 18;32(29):9824-30
references: 22815497
references: Vision Res. 2003 Feb;43(3):285-98
references: 12535987
references: J Neurophysiol. 2007 Sep;98(3):1167-80
references: 17596414
references: J Neurophysiol. 1987 Feb;57(2):357-80
references: 3559684
references: Brain Res. 2001 Jun 1;902(2):244-54
references: 11384618
references: J Neurosci. 1998 May 15;18(10):3870-96
references: 9570816
references: Eur J Neurosci. 2010 Jun;31(11):2086-100
references: 20604803
references: J Neurosci. 2005 Nov 23;25(47):10844-56
references: 16306397
references: Exp Brain Res. 1984;53(2):444-50
references: 6705873
references: Exp Brain Res. 1987;66(3):589-96
references: 3609203
references: Eur J Neurosci. 2002 Dec;16(11):2149-56
references: 12473082
references: J Neurosci. 2003 Nov 5;23(31):10040-51
references: 14602818
references: J Physiol. 1961 Feb;155:385-98
references: 13716436
references: Neuron. 2009 May 28;62(4):578-92
references: 19477158
references: Nature. 2003 Jul 17;424(6946):312-5
references: 12867982
references: J Neurosci. 2010 Oct 13;30(41):13558-66
references: 20943897
references: Prog Brain Res. 2006;154:93-120
references: 17010705
references: J Neurophysiol. 2009 Feb;101(2):958-68
references: 19073814
references: J Physiol. 1980 May;302:49-72
references: 7411466
references: Vis Neurosci. 2002 Sep-Oct;19(5):583-92
references: 12507325
references: J Neurosci. 2007 May 16;27(20):5431-6
references: 17507565
references: J Neurosci. 2001 Aug 1;21(15):5794-803
references: 11466451
references: Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1729-37
references: 12626007
references: J Neurosci. 2002 Jan 1;22(1):338-49
references: 11756517
references: J Neurosci. 2012 Nov 7;32(45):15946-51
references: 23136432
references: J Neurosci. 2006 Mar 8;26(10):2614-22
references: 16525040
references: Neuron. 2002 Dec 5;36(5):909-19
references: 12467594
references: J Physiol. 1979 May;290(2):141-61
references: 469742
references: J Neurosci. 2005 Jan 12;25(2):514-23
references: 15647497
references: J Physiol. 1966 Dec;187(3):517-52
references: 16783910
references: Nature. 2012 Oct 11;490(7419):226-31
references: 23060193
references: Proc Natl Acad Sci U S A. 1986 Apr;83(8):2755-7
references: 3458235
references: J Neurosci. 2007 Mar 7;27(10):2683-92
references: 17344406
references: J Neurophysiol. 1994 Jan;71(1):347-74
references: 8158236
references: J Physiol. 2000 Mar 15;523 Pt 3:755-69
references: 10718753
references: Exp Brain Res. 2000 Nov;135(2):279-84
references: 11131514
references: Vision Res. 1965 Dec;5(11):583-601
references: 5862581
references: Nature. 1987 Oct 22-28;329(6141):727-9
references: 3670375
references: J Neurosci. 2013 Jul 3;33(27):11145-54
references: 23825418
references: J Physiol. 1978 Mar;276:299-310
references: 650452
references: Nat Rev Neurosci. 2012 Jan;13(1):51-62
references: 22108672
references: J Physiol. 2011 Jan 1;589(Pt 1):87-99
references: 20603332
references: Neuron. 2000 Sep;27(3):635-46
references: 11055444