title: Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia in mice.
abstract: BACKGROUND
  Hyperglycemia associated with insulin resistance is common among critically ill patients. Interleukin (IL)-18 has been linked with hyperglycemia and insulin resistance in chronic disease, but the relation between IL-18 and insulin resistance during critical illness was unexplored. This study investigated whether IL-18 modulates hyperglycemia and insulin resistance during acute inflammation.
  
  
  METHODS
  We injected lipopolysaccharide (LPS) 40 mg/kg into wild-type (WT) and IL-18 knockout (KO) mice to induce endotoxemia and examined insulin resistance and insulin-dependent signaling pathways during the acute phase.
  
  
  RESULTS
  During the first hour after LPS treatment, IL-18 KO mice showed higher blood glucose and insulin and less insulin receptor substrate-1 and less phosphorylated Akt in the liver compared with WT mice. Interleukin-18 KO mice exhibited better survival after LPS treatment.
  
  
  CONCLUSIONS
  The findings suggest that endogenous IL-18 may attenuate hyperglycemia and modulate insulin signaling in liver. Accordingly, IL-18 may modulate glucose tolerance during acute inflammation.
authors: 1 Department of Biophysics, Kobe University Graduate School of Health Sciences , Hyogo, Japan .
authors: Hayato
authors: H
authors: Yamashita
authors: Michiko
authors: M
authors: Aoyama-Ishikawa
authors: Miki
authors: M
authors: Takahara
authors: Chisato
authors: C
authors: Yamauchi
authors: Taketo
authors: T
authors: Inoue
authors: Makoto
authors: M
authors: Miyoshi
authors: Noriaki
authors: N
authors: Maeshige
authors: Makoto
authors: M
authors: Usami
authors: Atsunori
authors: A
authors: Nakao
authors: Joji
authors: J
authors: Kotani
mesh_terms: D000818:Animals; D019446:Endotoxemia / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology*; D006943:Hyperglycemia / Q000150:complications* / Q000503:physiopathology*; D006946:Hyperinsulinism / Q000150:complications* / Q000503:physiopathology*; D007333:Insulin Resistance; D020382:Interleukin-18 / Q000235:genetics / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity; D008099:Liver / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015398:Signal Transduction
chemical_list: D020382:Interleukin-18; D008070:Lipopolysaccharides
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