title: Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities.
abstract: The present review describes research on novel natural isoquinoline alkaloids and their N-oxides isolated from different plant species. More than 200 biological active compounds have shown confirmed antimicrobial, antibacterial, antitumor, and other activities. The structures, origins, and reported biological activities of a selection of isoquinoline N-oxides alkaloids are reviewed. With the computer program PASS some additional SAR (structure-activity relationship) activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery.
authors: Institute of Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel. Electronic address: iddrdo@gmx.com.
authors: Valery M
authors: VM
authors: Dembitsky
authors: Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia.
authors: Tatyana A
authors: TA
authors: Gloriozova
authors: Institute of Biomedical Chemistry, Russian Academy of the Medical Sciences, Moscow 119121, Russia.
authors: Vladimir V
authors: VV
authors: Poroikov
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines; C039109:isoquinoline
keywords: Activities; Alkaloids; Antibacterial; Anticancer; Isoquinoline; SAR