title: The intrinsic resting state voice network in Parkinson's disease.
abstract: Over 90 percent of patients with Parkinson's disease experience speech-motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting-state functional connectivity analysis of blood oxygen level-dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting-state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta-analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender-, age-, and movement-matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ-39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within-group analyses of connectivity patterns demonstrated a lack of subcortical-cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease.
authors: University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, Texas.
authors: Anneliese B
authors: AB
authors: New
authors: Donald A
authors: DA
authors: Robin
authors: Amy L
authors: AL
authors: Parkinson
authors: Claudia R
authors: CR
authors: Eickhoff
authors: Kathrin
authors: K
authors: Reetz
authors: Felix
authors: F
authors: Hoffstaedter
authors: Christian
authors: C
authors: Mathys
authors: Martin
authors: M
authors: Sudmeyer
authors: Christian
authors: C
authors: Grefkes
authors: Charles R
authors: CR
authors: Larson
authors: Loraine O
authors: LO
authors: Ramig
authors: Peter T
authors: PT
authors: Fox
authors: Simon B
authors: SB
authors: Eickhoff
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology*; D012146:Rest; D012720:Severity of Illness Index; D014831:Voice / Q000502:physiology
keywords: Parkinson's disease; functional connectivity; neuroimaging; resting-state; voice network
references: Neuroimage. 2013 Dec;83:45-57
references: 23792981
references: Cereb Cortex. 2011 Apr;21(4):932-7
references: 20833698
references: Neuroimage. 2013 Feb 15;67:237-46
references: 23201364
references: Hum Brain Mapp. 2010 Feb;31(2):222-36
references: 19639554
references: Neuroimage. 2013 Dec;83:837-48
references: 23872155
references: Mov Disord. 2011 Oct;26(12):2212-9
references: 21714000
references: Neuroimage. 2012 Sep;62(3):1354-66
references: 22659444
references: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3131-6
references: 22323591
references: J Neural Transm Suppl. 2002;(62):347-76
references: 12456078
references: Cortex. 2010 Jul-Aug;46(7):831-44
references: 20152963
references: Neurology. 2012 Dec 4;79(23):2226-32
references: 23100395
references: Brain Struct Funct. 2014 Mar;219(2):581-94
references: 23423461
references: J Chem Neuroanat. 2001 Jul;22(1-2):3-12
references: 11470551
references: Clin EEG Neurosci. 2011 Apr;42(2):107-21
references: 21675600
references: PLoS One. 2013 Apr 19;8(4):e61786
references: 23620791
references: J Neural Transm (Vienna). 2012 Apr;119(4):443-54
references: 22002597
references: Neurosci Lett. 2012 Aug 22;524(1):55-9
references: 22813979
references: J Neurol. 2013 Nov;260(11):2823-30
references: 23974647
references: Neuroimage. 2013 Apr 15;70:21-32
references: 23277111
references: Brain. 2000 Jan;123 ( Pt 1):155-63
references: 10611129
references: Neuroimage. 2012 May 15;61(1):314-22
references: 22406500
references: PLoS One. 2012;7(9):e43516
references: 22970130
references: Hum Brain Mapp. 2014 Apr;35(4):1681-90
references: 23861334
references: Neuroimage. 2012 Mar;60(1):162-9
references: 22209784
references: Brain Cogn. 2009 Jun;70(1):31-41
references: 19162389
references: Parkinsonism Relat Disord. 2005 Sep;11(6):353-61
references: 16105745
references: Neuroimage. 2006 Aug 1;32(1):376-87
references: 16631384
references: Hum Brain Mapp. 2008 Jul;29(7):737-9
references: 18465798
references: AJNR Am J Neuroradiol. 2012 Oct;33(9):1804-9
references: 22538070
references: J Neurophysiol. 2012 Oct;108(8):2242-63
references: 22832566
references: Brain. 2012 Dec;135(Pt 12):3699-711
references: 23195207
references: J Neurophysiol. 2008 Oct;100(4):1740-8
references: 18701759
references: Brain Lang. 2014 May;132:7-13
references: 24681401
references: Brain Lang. 2006 Mar;96(3):280-301
references: 16040108
references: J Comp Neurol. 1997 Nov 3;387(4):588-630
references: 9373015
references: Neurol Sci. 2014 Aug;35(8):1173-80
references: 24554416
references: PLoS One. 2011 Mar 03;6(3):e14744
references: 21390228
references: J Neurol Sci. 2012 Feb 15;313(1-2):7-12
references: 22078745
references: Neuroimage. 2013 Jan 1;64:240-56
references: 22926292
references: Cereb Cortex. 2001 Oct;11(10):946-53
references: 11549617
references: J Speech Lang Hear Res. 2014 Aug;57(4):1330-43
references: 24686571
references: Neurology. 2003 Feb 11;60(3):432-40
references: 12578924
references: Neuroimage. 2012 Mar;60(1):623-32
references: 22233733
references: Neuroimage. 2012 Jan 2;59(1):431-8
references: 21810475
references: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references: 17704812
references: Neuroimage. 2005 Jul 1;26(3):839-51
references: 15955494
references: Neuroimage. 2012 Feb 1;59(3):2142-54
references: 22019881
references: Front Syst Neurosci. 2014 Apr 03;8:45
references: 24765065
references: Neuroimage. 2012 May 1;60(4):2389-98
references: 22387170
references: Behav Neurol. 2012;25(2):111-8
references: 22530265
references: Brain Connect. 2013;3(3):265-72
references: 23627641
references: Neuroimage. 2006 Aug 15;32(2):821-41
references: 16730195