title: A novel behavioral paradigm to assess multisensory processing in mice.
abstract: Human psychophysical and animal behavioral studies have illustrated the benefits that can be conferred from having information available from multiple senses. Given the central role of multisensory integration for perceptual and cognitive function, it is important to design behavioral paradigms for animal models to provide mechanistic insights into the neural bases of these multisensory processes. Prior studies have focused on large mammals, yet the mouse offers a host of advantages, most importantly the wealth of available genetic manipulations relevant to human disease. To begin to employ this model species for multisensory research it is necessary to first establish and validate a robust behavioral assay for the mouse. Two common mouse strains (C57BL/6J and 129S6/SvEv) were first trained to respond to unisensory (visual and auditory) stimuli separately. Once trained, performance with paired audiovisual stimuli was then examined with a focus on response accuracy and behavioral gain. Stimulus durations varied from 50 ms to 1 s in order to modulate the effectiveness of the stimuli and to determine if the well-established "principle of inverse effectiveness" held in this model. Response accuracy in the multisensory condition was greater than for either unisensory condition for all stimulus durations, with significant gains observed at the 300 ms and 100 ms durations. Main effects of stimulus duration, stimulus modality and a significant interaction between these factors were observed. The greatest behavioral gain was seen for the 100 ms duration condition, with a trend observed that as the stimuli became less effective, larger behavioral gains were observed upon their pairing (i.e., inverse effectiveness). These results are the first to validate the mouse as a species that shows demonstrable behavioral facilitations under multisensory conditions and provides a platform for future mechanistically directed studies to examine the neural bases of multisensory integration.
authors: Multisensory Research Laboratory, Neuroscience Program, Vanderbilt University Nashville, TN, USA.
authors: Justin K
authors: JK
authors: Siemann
authors: Neuroscience Program, Vanderbilt University Nashville, TN, USA.
authors: Christopher L
authors: CL
authors: Muller
authors: Computer Software Engineering Department, MED Associates Inc. St. Albans, VT, USA.
authors: Gary
authors: G
authors: Bamberger
authors: Murine Neurobehavior Core, Vanderbilt University Nashville, TN, USA.
authors: John D
authors: JD
authors: Allison
authors: Center for Autism and the Developing Brain, and Department of Psychiatry, Sackler Institute for Developmental Psychobiology, Columbia University New York, NY, USA.
authors: Jeremy
authors: J
authors: Veenstra-VanderWeele
authors: Department of Hearing and Speech Sciences, Vanderbilt University Nashville, TN, USA ; Department of Psychology, Vanderbilt University Nashville, TN, USA ; Department of Psychiatry, Vanderbilt University Nashville, TN, USA.
authors: Mark T
authors: MT
authors: Wallace
keywords: auditory processing; mouse behavior; mouse models; multisensory integration; operant conditioning; visual processing
references: Nat Rev Neurosci. 2010 Jul;11(7):490-502
references: 20559336
references: Neuropsychiatr Dis Treat. 2014 Jul 22;10:1369-79
references: 25092982
references: Schizophr Res. 2009 Feb;107(2-3):286-93
references: 18986799
references: Neuropsychologia. 2014 Nov;64:105-23
references: 25128432
references: Methods Mol Biol. 2009;489:213-42
references: 18839094
references: Vision Res. 2000;40(16):2201-9
references: 10878281
references: J Autism Dev Disord. 2014 Dec;44(12):3161-7
references: 25022248
references: Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2167-72
references: 14766982
references: Behav Brain Sci. 2004 Dec;27(6):771-87; discussion 787-830
references: 16035402
references: J Physiol Paris. 2004 Jan-Jun;98(1-3):249-58
references: 15477036
references: Behav Brain Res. 1999 Dec;106(1-2):55-73
references: 10595422
references: J Autism Dev Disord. 2008 Sep;38(8):1485-98
references: 18302014
references: Neuroscience. 2004;124(3):535-47
references: 14980725
references: Neuron. 2013 Aug 7;79(3):579-93
references: 23850594
references: Nat Neurosci. 2011 Jun;14(6):775-82
references: 21552274
references: Front Syst Neurosci. 2014 Sep 18;8:173
references: 25278849
references: Nat Neurosci. 2014 Dec;17(12):1784-92
references: 25383902
references: Neuron. 2005 Nov 3;48(3):497-507
references: 16269366
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Oct;195(10):961-9
references: 19756650
references: Trends Cogn Sci. 2010 Sep;14(9):400-10
references: 20675182
references: Brain Res Cogn Brain Res. 2003 Jul;17(2):447-53
references: 12880914
references: Autism. 2007 Mar;11(2):123-34
references: 17353213
references: Nat Rev Neurosci. 2008 Apr;9(4):255-66
references: 18354398
references: J Cogn Neurosci. 2002 Nov 15;14(8):1240-55
references: 12495529
references: Annu Rev Neurosci. 2011;34:389-412
references: 21692661
references: Neuron. 2014 Sep 3;83(5):1200-12
references: 25155959
references: Neuroscience. 2006;139(4):1507-24
references: 16529873
references: Neuroscientist. 2002 Aug;8(4):306-14
references: 12194499
references: Neuroscience. 2014 Jan 3;256:147-62
references: 24183964
references: Front Behav Neurosci. 2013 Aug 15;7:106
references: 23966917
references: Cereb Cortex. 2015 Feb;25(2):298-312
references: 23985136
references: Dis Markers. 2012;33(5):225-39
references: 22960336
references: J Neurodev Disord. 2010 Jun;2(2):62-9
references: 22127855
references: Science. 1983 Jul 22;221(4608):389-91
references: 6867718
references: Exp Brain Res. 2009 Sep;198(2-3):127-36
references: 19308362
references: J Child Psychol Psychiatry. 2009 Apr;50(4):491-7
references: 19207623
references: Exp Brain Res. 2007 May;179(2):325-38
references: 17146648
references: Pediatr Res. 2011 May;69(5 Pt 2):48R-54R
references: 21289533
references: Brain Topogr. 2014 Nov;27(6):707-30
references: 24722880
references: Schizophr Res. 2003 Feb 1;59(2-3):211-8
references: 12414077
references: Schizophr Res. 2005 Jan 1;72(2-3):195-203
references: 15560964
references: Eur J Neurosci. 2012 Oct;36(7):2949-63
references: 22780435
references: Science. 1985 Feb 8;227(4687):657-9
references: 3969558
references: J Neurosci. 2014 Jan 15;34(3):691-7
references: 24431427
references: J Physiol Paris. 2004 Jan-Jun;98(1-3):191-205
references: 15477032
references: Nat Neurosci. 2013 Jul;16(7):824-31
references: 23799475
references: Cereb Cortex. 2005 Nov;15(11):1690-6
references: 15703251
references: Schizophr Res. 2013 Jul;147(2-3):253-61
references: 23707640
references: J Vis. 2013 May 08;13(6):null
references: 23658374
references: J Neurosci. 2013 Mar 27;33(13):5736-49
references: 23536087
references: Neurosci Biobehav Rev. 2014 Sep;45:271-94
references: 25016072
references: J Autism Dev Disord. 2006 Jan;36(1):77-90
references: 16395537
references: J Neurophysiol. 1986 Sep;56(3):640-62
references: 3537225
references: J Neurosci. 2012 Mar 14;32(11):3726-35
references: 22423093
references: Neuron. 2011 Oct 20;72 (2):357-69
references: 22017993
references: Cereb Cortex. 2008 Dec;18(12):2941-51
references: 18424777
references: Nat Neurosci. 2005 Sep;8(9):1203-9
references: 16116444
references: Neurosci Res. 2014 Oct;87:49-55
references: 25066521
references: Neuron. 2014 Aug 20;83(4):894-905
references: 25088363
references: J Neurophysiol. 1994 Jan;71(1):429-32
references: 8158240
references: J Neurosci. 1987 Oct;7(10):3215-29
references: 3668625
references: PLoS One. 2012;7(9):e45677
references: 23029179
references: Eur J Neurosci. 2011 Jul;34(1):65-78
references: 21676038
references: Neurosci Biobehav Rev. 2012 Feb;36(2):836-54
references: 22155284
references: J Child Psychol Psychiatry. 2007 Aug;48(8):813-21
references: 17683453
references: Schizophr Bull. 2009 Nov;35(6):1059-64
references: 19833806
references: Exp Brain Res. 2004 Dec;159(4):409-17
references: 15249987
references: J Neurosci. 2011 Aug 3;31(31):11351-61
references: 21813694
references: Exp Brain Res. 2012 May;219(1):121-37
references: 22447249
references: Neuroscience. 2008 Jun 2;153(4):1402-17
references: 18440715
references: J Neurophysiol. 2007 Jan;97(1):921-6
references: 16914616
references: Exp Brain Res. 2010 Jun;203(2):381-9
references: 20390256
references: J Pharmacol Sci. 2013;121(3):185-91
references: 23449491
references: Autism Res. 2010 Oct;3(5):253-67
references: 20730775
references: J Comp Neurol. 2003 May 26;460(2):223-37
references: 12687687
references: Mamm Genome. 2000 Jul;11(7):531-6
references: 10886018
references: J Autism Dev Disord. 2014 Jun;44(6):1470-7
references: 24218241
references: Cereb Cortex. 2013 Jun;23(6):1329-41
references: 22628458
references: Exp Brain Res. 1992;91(3):484-8
references: 1483520
references: J Cogn Neurosci. 2010 Dec;22(12):2850-63
references: 20044892
references: Autism. 2012 Jul;16(4):406-19
references: 22399451
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2004 Dec;190(12):1039-46
references: 15480703
references: Front Integr Neurosci. 2011 Jan 05;4:129
references: 21258617
references: PLoS One. 2011;6(9):e25283
references: 21966481
references: Exp Brain Res. 1996 Nov;112(1):1-10
references: 8951401
references: Neuropsychologia. 2013 Jan;51(2):358-71
references: 22813430
references: Brain Res. 1986 Feb 19;365(2):350-4
references: 3947999