title: MicroRNA -143 and -223 in obesity.
abstract: BACKGROUND
  Obesity alters endocrine and metabolic functions of adipose tissue and has been recognized as a chronic inflammatory disease, which in turn may contribute to the development of insulin resistance, type 2 diabetes, obesity-associated vasculopathy and cardiovascular disease. The pathogenesis of obesity involves many regulatory pathways including transcriptional regulatory networks, including microRNAs.
  
  
  METHODS
  A total of 83 patients were included in the study. Patients were recruited from a cardiology outpatient clinic and were allocated into 3 age- and sex-matched groups according to their body mass index. Group 1 included 23 morbidly obese, group 2 30 obese, and group 3 30 normal or overweight subjects.
  
  
  RESULTS
  In our study, we showed that miR-143 and miR-223 levels were significantly lower in groups 1 and 2 than the control group (normal BMI or overweight).
  
  
  CONCLUSIONS
  Obesity leads to alterations in miRNA expressions and miRNA-143 and -223s can be used as biomarkers for the metabolic changes in obesity.
authors: Pamukkale University, Medical Faculty, Department of Cardiology, Denizli, Turkey.
authors: Ismail Dogu
authors: ID
authors: Kilic
authors: Pamukkale University, Medical Faculty, Department of Medical Biology, Denizli, Turkey.
authors: Yavuz
authors: Y
authors: Dodurga
authors: Pamukkale University, Medical Faculty, Department of Cardiology, Denizli, Turkey.
authors: Burcu
authors: B
authors: Uludag
authors: Pamukkale University, Medical Faculty, Department of Cardiology, Denizli, Turkey.
authors: Yusuf I
authors: YI
authors: Alihanoglu
authors: Pamukkale University, Medical Faculty, Department of Cardiology, Denizli, Turkey.
authors: Bekir Serhat
authors: BS
authors: Yildiz
authors: Pamukkale University, Department of Biochemistry, Denizli, Turkey.
authors: Yasar
authors: Y
authors: Enli
authors: Pamukkale University, Medical Faculty, Department of Medical Biology, Denizli, Turkey.
authors: Mucahit
authors: M
authors: Secme
authors: Pamukkale University, Department of Biochemistry, Denizli, Turkey.
authors: H Eren
authors: HE
authors: Bostancı
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006596:Hexosaminidases / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000235:genetics; D009195:Peroxidase / Q000097:blood
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D006596:Hexosaminidases; D035683:MicroRNAs; D009195:Peroxidase; C542359:MIRN143 microRNA, human; C525067:MIR223, human; C086400:chitotriosidase
keywords: Obesity; microRNA-143; microRNA-223