title: Chemokine receptors and their therapeutic opportunities in diseased lung: far beyond leukocyte trafficking.
abstract: Chemokine receptors and their chemokine ligands, key mediators of inflammatory and immune cell trafficking, are involved in the regulation of both physiological and pathological processes in the lung. The discovery that chemokine receptors/chemokines, typically expressed by inflammatory and immune cells, are also expressed in structural lung tissue cells suggests their role in mediating the restoration of lung tissue structure and functions. Thus, chemokine receptors/chemokines contribute not only to inflammatory and immune responses in the lung but also play a critical role in the regulation of lung tissue repair, regeneration, and remodeling. This review aims to summarize current state-of-the-art on chemokine receptors and their ligands in lung diseases such as chronic obstructive pulmonary disease, asthma/allergy, pulmonary fibrosis, acute lung injury, and lung infection. Furthermore, the therapeutic opportunities of chemokine receptors in aforementioned lung diseases are discussed. The review also aims to delineate the potential contribution of chemokine receptors to the processes leading to repair/regeneration of the lung tissue.
authors: Faculty of Medicine and Dentistry, Department of Immunology, Palacky University Olomouc, Czech Republic; Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; and.
authors: Tereza
authors: T
authors: Tomankova
authors: Faculty of Medicine and Dentistry, Department of Immunology, Palacky University Olomouc, Czech Republic;
authors: Eva
authors: E
authors: Kriegova
authors: Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; and Faculty of Medicine, Departments of Physiology, Surgery, and Medicine, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada mingyao.liu@utoronto.ca.
authors: Mingyao
authors: M
authors: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D002465:Cell Movement; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D019707:Receptors, Chemokine / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D019707:Receptors, Chemokine
keywords: asthma; chemokines; chronic obstructive pulmonary disease; infection; injury; lung fibrosis; therapeutics; tissue repair