title: Classification of histologically scored human knee osteochondral plugs by quantitative analysis of magnetic resonance images at 3T.
abstract: This work evaluates the ability of quantitative MRI to discriminate between normal and pathological human osteochondral plugs characterized by the Osteoarthritis Research Society International (OARSI) histological system. Normal and osteoarthritic human osteochondral plugs were scored using the OARSI histological system and imaged at 3 T using MRI sequences producing T1 and T2 contrast and measuring T1, T2, and T2* relaxation times, magnetization transfer, and diffusion. The classification accuracies of quantitative MRI parameters and corresponding weighted image intensities were evaluated. Classification models based on the Mahalanobis distance metric for each MRI measurement were trained and validated using leave-one-out cross-validation with plugs grouped according to OARSI histological grade and score. MRI measurements used for classification were performed using a region-of-interest analysis which included superficial, deep, and full-thickness cartilage. The best classifiers based on OARSI grade and score were T1- and T2-weighted image intensities, which yielded accuracies of 0.68 and 0.75, respectively. Classification accuracies using OARSI score-based group membership were generally higher when compared with grade-based group membership. MRI-based classification--either using quantitative MRI parameters or weighted image intensities--is able to detect early osteoarthritic tissue changes as classified by the OARSI histological system. These findings suggest the benefit of incorporating quantitative MRI acquisitions in a comprehensive clinical evaluation of OA.
authors: Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, 3001 S. Hanover Street, Baltimore, Maryland.
authors: Vanessa A
authors: VA
authors: Lukas
authors: Kenneth W
authors: KW
authors: Fishbein
authors: Ping-Chang
authors: PC
authors: Lin
authors: Michael
authors: M
authors: Schär
authors: Erika
authors: E
authors: Schneider
authors: Corey P
authors: CP
authors: Neu
authors: Richard G
authors: RG
authors: Spencer
authors: David A
authors: DA
authors: Reiter
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*
keywords: cartilage matrix; classification; imaging; osteoarthritis; quantitative MRI
references: Osteoarthritis Cartilage. 2005 May;13(5):368-78
references: 15882560
references: Ann Rheum Dis. 1957 Dec;16(4):494-502
references: 13498604
references: Semin Musculoskelet Radiol. 2004 Dec;8(4):355-68
references: 15643574
references: Osteoarthritis Cartilage. 2011 May;19(5):478-82
references: 21396464
references: AJR Am J Roentgenol. 2006 Sep;187(3):794-9
references: 16928947
references: Skeletal Radiol. 2012 Mar;41(3):287-92
references: 21499976
references: Osteoarthritis Cartilage. 2006 Jan;14(1):13-29
references: 16242352
references: Childs Nerv Syst. 2001 Apr;17(4-5):195-201
references: 11398937
references: Magn Reson Imaging. 2001 Dec;19(10):1279-86
references: 11804755
references: Am J Sports Med. 1989 Jul-Aug;17(4):505-13
references: 2675649
references: J Orthop Res. 1993 Jul;11(4):465-78
references: 8340820
references: J Magn Reson Imaging. 2015 Jul;42(1):136-44
references: 25327944
references: Osteoarthritis Cartilage. 2013 Apr;21(4):535-43
references: 23274104
references: J Magn Reson Imaging. 1999 Oct;10(4):497-502
references: 10508315
references: Osteoarthritis Cartilage. 2007 Nov;15(11):1241-8
references: 17576080
references: Osteoarthritis Cartilage. 2012 Jul;20(7):686-93
references: 22430052
references: Radiology. 2006 Jun;239(3):818-24
references: 16641340
references: Osteoarthritis Cartilage. 2006 Dec;14(12):1265-71
references: 16843689
references: Magn Reson Med. 2002 Sep;48(3):460-9
references: 12210910
references: J Magn Reson Imaging. 2003 Apr;17(4):440-4
references: 12655583
references: J Orthop Res. 2004 May;22(3):557-64
references: 15099635
references: Magn Reson Med. 1996 Nov;36(5):665-73
references: 8916016
references: Arthritis Rheum. 2010 Sep;62(9):2680-7
references: 20499384
references: Osteoarthritis Cartilage. 2008 Dec;16(12):1433-41
references: 18786841
references: Magn Reson Med. 2009 Nov;62(5):1311-8
references: 19705467
references: Osteoarthritis Cartilage. 2013 Feb;21(2):394-400
references: 23186942
references: Eur J Radiol. 2013 Apr;82(4):647-50
references: 23333531
references: J Bone Joint Surg Am. 1971 Apr;53(3):523-37
references: 5580011
references: J Magn Reson Imaging. 2003 Mar;17(3):358-64
references: 12594727
references: Ann Rheum Dis. 2008 Feb;67(2):206-11
references: 17472995
references: Ann Rheum Dis. 2006 Apr;65(4):433-41
references: 16126797
references: AJR Am J Roentgenol. 2007 Dec;189(6):1510-5
references: 18029893
references: Osteoarthritis Cartilage. 1995 Sep;3(3):169-80
references: 8581746
references: AJR Am J Roentgenol. 2000 Feb;174(2):405-9
references: 10658715
references: Rheumatol Int. 2010 Feb;30(4):435-42
references: 19816688
references: Magn Reson Med. 2004 Mar;51(3):503-9
references: 15004791
references: Radiology. 2012 Aug;264(2):484-93
references: 22653187
references: Invest Radiol. 2000 Oct;35(10):622-38
references: 11041156
references: Magn Reson Med. 2014 Feb;71(2):807-14
references: 23553981
references: J Bone Joint Surg Am. 1998 Sep;80(9):1276-84
references: 9759811
references: Osteoarthritis Cartilage. 2013 May;21(5):710-20
references: 23376528
references: Radiology. 1996 Nov;201(2):525-30
references: 8888253
references: J Magn Reson Imaging. 2005 Apr;21(4):476-81
references: 15779031
references: Eur J Radiol. 2009 Jun;70(3):561-9
references: 18434064
references: Bone Joint J. 2013 Jun;95-B(6):738-46
references: 23723266
references: J Am Acad Orthop Surg. 2013 Jul;21(7):438-9
references: 23818031
references: Arthritis Rheum. 2007 Nov;56(11):3706-14
references: 17968924
references: Instr Course Lect. 1998;47:477-86
references: 9571449
references: J Magn Reson. 2009 Nov;201(1):61-71
references: 19762258