title: Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis.
abstract: Cytochrome P450 1A1 (CYP1A1) usually metabolizes carcinogens to their inactive derivatives but occasionally converts the chemicals to more potent carcinogens. To date, many studies have evaluated the association between the CYP1A1 MspI and Ile462Val polymorphisms and renal cell carcinoma (RCC) risk, but the results have been conflicting. To more precisely evaluate the potential association, we carried out a meta-analysis of seven published case-control studies. The meta-analysis indicated that the MspI polymorphism was associated with an increased RCC risk (allele model: OR = 1.49, 95%CI 1.03-2.16; homozygous model: OR = 1.64, 95%CI 1.13-2.40; dominant model: OR = 1.72, 95%CI 1.07-2.76). No significant associations were found for the Ile462Val polymorphism for all genetic models. When stratified by smoking status, smokers carrying the variant Vt and Val allele were more susceptible to RCC (Vt allele: OR = 3.37, 95%CI = 2.24-5.06; Val allele: OR = 2.07, 95%CI = 1.34-3.19). These data indicate that the CYP1A1 MspI polymorphism significantly increased RCC risk, while the Ile462Val polymorphism was not associated with RCC. Among smokers, individuals with the CYP1A1 Vt allele and Val allele showed a significantly increased risk of RCC. More well-designed studies with larger samples are warranted to show the underlying mechanisms of CYP1A1 in the development of RCC.
authors: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang 110001, China.
authors: Fan-dong
authors: FD
authors: Meng
authors: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang 110001, China.
authors: Ping
authors: P
authors: Ma
authors: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang 110001, China.
authors: Cheng-guang
authors: CG
authors: Sui
authors: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang 110001, China.
authors: Xin
authors: X
authors: Tian
authors: Molecular Oncology Department of Cancer Research Institution, The First Hospital of China Medical University, Shenyang 110001, China.
authors: You-hong
authors: YH
authors: Jiang
mesh_terms: D000483:Alleles; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology / Q000235:genetics*; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D019363:Cytochrome P-450 CYP1A1
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