title: The evolving cancer stem cell paradigm: implications in veterinary oncology.
abstract: The existence of subpopulations of cells in cancer with increased tumour-initiating ability, self-renewal potential, and intrinsic resistance to conventional therapeutics formed the basis of the cancer stem cell model. Some tumours have since been viewed as aberrant tissues with a unidirectional hierarchical structure consisting of cancer stem cells at the apex, driving tumour growth, metastasis and relapse after therapy. Here, recent developments in cancer stem cell research are reviewed with a focus on tumour heterogeneity, cellular plasticity and cancer stem cell reprogramming. The impact of these findings on the cancer stem cell model is discussed.
authors: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address: lisa.pang@ed.ac.uk.
authors: Lisa Y
authors: LY
authors: Pang
authors: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
authors: David J
authors: DJ
authors: Argyle
mesh_terms: D000818:Animals; D000066670:Cell Plasticity; D002471:Cell Transformation, Neoplastic; D065150:Cellular Reprogramming; D015972:Gene Expression Regulation, Neoplastic; D009369:Neoplasms / Q000662:veterinary*; D014411:Neoplastic Stem Cells / Q000502:physiology*
keywords: Cancer cell plasticity; Cancer stem cells; Cellular reprogramming; Lineage tracing; Stemness; Tumour heterogeneity