title: Effect of propofol on brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus of aged rats with chronic cerebral ischemia.
abstract: We intraperitoneally injected 10 and 50 mg/kg of propofol for 7 consecutive days to treat a rat model of chronic cerebral ischemia. A low-dose of propofol promoted the expression of brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element binding protein, and cAMP in the hippocampus of aged rats with chronic cerebral ischemia, but a high-dose of propofol inhibited their expression. Results indicated that the protective effect of propofol against cerebral ischemia in aged rats is related to changes in the expression of brain-derived neurotrophic factor and tyrosine kinase receptor B in the hippocampus, and that the cAMP-cAMP responsive element binding protein pathway is involved in the regulatory effect of propofol on brain-derived neurotrophic factor expression.
authors: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.
authors: Gang
authors: G
authors: Chen
authors: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.
authors: Qiang
authors: Q
authors: Fu
authors: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.
authors: Jiangbei
authors: J
authors: Cao
authors: Anesthesia and Operation Center, PLA General Hospital, Beijing 100853, China.
authors: Weidong
authors: W
authors: Mi
keywords: aged; brain-derived neurotrophic factor; cAMP-cAMP responsive element binding protein; chronic cerebral ischemia; neural regeneration; propofol; tyrosine kinase receptor B
references: Jpn J Cancer Res. 2001 Feb;92(2):152-60
references: 11223544
references: Neuron. 2002 Aug 15;35(4):605-23
references: 12194863
references: Acta Neurobiol Exp (Wars). 2010;70(4):370-81
references: 21196945
references: Brain Res. 1992 Jun 12;582(2):186-95
references: 1327402
references: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):81-6
references: 17764798
references: Life Sci. 1999;65(21):2205-13
references: 10576592
references: Neuroscience. 1998 Apr;83(4):1155-60
references: 9502254
references: J Neurochem. 1996 Sep;67(3):1124-31
references: 8752119
references: Rejuvenation Res. 2012 Feb;15(1):98-101
references: 22352436
references: Neuroscience. 1999 Mar;89(2):437-52
references: 10077326
references: Dev Neurosci. 1999;21(1):68-75
references: 10077704
references: Trends Neurosci. 2000 Feb;23(2):48-53
references: 10652539
references: Brain Res. 1999 Feb 13;818(2):520-6
references: 10082840
references: Neurosci Lett. 1996 Jun 14;211(1):57-60
references: 8809847
references: Zhonghua Yi Xue Za Zhi. 2007 Mar 20;87(11):763-7
references: 17565847
references: Brain Res. 2010 Oct 14;1356:11-23
references: 20707988
references: Neurosci Lett. 2009 Dec 31;467(3):247-51
references: 19853639
references: Eur J Anaesthesiol. 2009 Apr;26(4):279-84
references: 19401659
references: Neuroscience. 1997 May;78(2):431-48
references: 9145800
references: Dev Neurobiol. 2008 Dec;68(14 ):1565-79
references: 18837011
references: Mol Cell Neurosci. 2004 Jul;26(3):470-80
references: 15234351
references: Anesth Analg. 2008 Dec;107(6):2009-16
references: 19020152
references: Masui. 2000 Feb;49(2):130-8
references: 10707515
references: Neurobiol Aging. 1993 Mar-Apr;14(2):121-6
references: 8487914