title: Systems biology of polycystic kidney disease: a critical review.
abstract: The proliferation and diminishing costs of 'omics' approaches have finally opened the doors for small and medium laboratories to enter the 'systems biology era'. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the 'cyst-ems biology' of polycystic kidney disease.
authors: Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
authors: Luis Fernando
authors: LF
authors: Menezes
authors: Gregory G
authors: GG
authors: Germino
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008954:Models, Biological; D016891:Polycystic Kidney, Autosomal Dominant / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D049490:Systems Biology / Q000379:methods; D050396:TRPP Cation Channels / Q000378:metabolism*
chemical_list: D020543:Proteome; D050396:TRPP Cation Channels
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