title: Cation exchange-based post-processing of (68)Ga-eluate: a comparison of three solvent systems for labelling of DOTATOC, NO2AP(BP) and DATA(m.).
abstract: Interest in (68)Ga has led to a number of innovations for its provision suitable for clinical application. Several post-processing methods are available to reduce eluate volume and remove metal trace impurities. In this work three cation exchange resin based post-processing methods (acetone, ethanol and NaCl) have been compared, using three model precursors (DOTATOC, NO2AP(BP) and DATA(m)), in terms of labelling yield and reproducibility. The acetone and ethanol based methods provided greater reproducibility and yields that makes subsequent purification unnecessary.
authors: Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
authors: Johanna
authors: J
authors: Seemann
authors: Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
authors: Elisabeth
authors: E
authors: Eppard
authors: Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
authors: Bradley P
authors: BP
authors: Waldron
authors: Department of Nuclear Medicine, Hannover Medical School, 30625 Hannover, Germany.
authors: Tobias L
authors: TL
authors: Ross
authors: Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.. Electronic address: frank.roesch@uni-mainz.de.
authors: Frank
authors: F
authors: Roesch
keywords: Acetone; DOTATOC; Ethanol; Gallium-68; NaCl; Post-processing