title: Synthesis and DNA binding profile of N-mono- and N,N'-disubstituted indolo[3,2-b]carbazoles.
abstract: A series of N-monosubstituted and N,N'-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It has been found that indolo[3,2-b]carbazoles bearing basic N-alkyl substituents are intercalators that bind DNA with affinities in the micromolar and submicromolar range and a preference for associating with sequences of mixed composition and purine-pyrimidine steps.
authors: Department of Chemistry and Biochemistry, California State University, Northridge, 18111 Nordhoff Street, Northridge, CA 91330, USA. thomas.minehan@csun.edu.
authors: Harmanpreet Kaur
authors: HK
authors: Panesar
authors: Jennifer
authors: J
authors: Solano
authors: Thomas G
authors: TG
authors: Minehan
mesh_terms: D000818:Animals; D002227:Carbazoles / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D009930:Organic Chemicals; D010539:Permeability; D011485:Protein Binding; D011687:Purines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013950:Thymus Gland / Q000378:metabolism
chemical_list: D002227:Carbazoles; D007211:Indoles; D007364:Intercalating Agents; D008024:Ligands; D009930:Organic Chemicals; D011687:Purines; D011725:Pyridines; D004247:DNA
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