title: Overcoming multiple drug resistance by spatial-temporal synchronization of epirubicin and pooled siRNAs.
abstract: One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP). The resulting EPI-RNA-CaP nanocomplexes can achieve a spatial-temporal synchronous effect to full-scale overcome sophisticated multiple drug resistance (MDR) by simultaneous inhibitions of drug efflux and intracellular anti-apoptotic defense to maximize the therapeutic efficacy.
authors: Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
authors: Wei
authors: W
authors: Chen
authors: Xueyao
authors: X
authors: Liu
authors: Yun
authors: Y
authors: Xiao
authors: Ruikang
authors: R
authors: Tang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics*; D002130:Calcium Phosphates / Q000737:chemistry; D004338:Drug Combinations; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D015251:Epirubicin / Q000008:administration & dosage*; D020868:Gene Silencing; D056945:Hep G2 Cells; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics*; D062211:Spatio-Temporal Analysis
chemical_list: D000903:Antibiotics, Antineoplastic; C000595707:BCL2 protein, human; D002130:Calcium Phosphates; D004338:Drug Combinations; D053769:Nanocapsules; D019253:Proto-Oncogene Proteins c-bcl-2; D034741:RNA, Small Interfering; D015251:Epirubicin; C020243:calcium phosphate
keywords: RNA interference; epirubicin; gene therapy; multiple drug resistance; synergistic effect