title: A new polymorph of 1-hydroxy-2-naphthoic acid obtained during failed co-crystallization experiments.
abstract: Pharmaceutical salt-forming acid 1-hydroxy-2-naphthoic acid (HNA) is widely used in pharmaceutical co-crystal preparation. In this work, we report a new polymorph of HNA obtained during attempted co-crystallization experiments. The reported form and the new form were fully characterized and their thermodynamic relationship was also established to be monotropic with the new form being the more stable form.
authors: Pharmaceutical Analytical and Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang High-Tech Park, Shanghai 201203, People's Republic of China.
authors: Qi
authors: Q
authors: Zhang
authors: Pharmaceutical Analytical and Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang High-Tech Park, Shanghai 201203, People's Republic of China.
authors: Meiqi
authors: M
authors: Li
authors: Pharmaceutical Analytical and Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang High-Tech Park, Shanghai 201203, People's Republic of China.
authors: Xuefeng
authors: X
authors: Mei
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009284:Naphthols / Q000737:chemistry*; D033362:Powder Diffraction; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D009284:Naphthols; C050175:1-hydroxy-2-naphthoic acid
keywords: phase transition; polymorphism; stability