title: A general method for the one-pot reductive functionalization of secondary amides.
abstract: A one-pot reaction for the transformation of common secondary amides into amines with C-C bond formation is described. This method consists of in situ amide activation with Tf2O-partial reduction-addition of C-nucleophiles. The method is general in scope, which allows employing both hard nucleophiles (RMgX, RLi) and soft nucleophiles, as well as enolates. With the use of soft nucleophiles, the reaction proceeded with high chemoselectivity at a secondary amide in the presence of ester, cyano, nitro, and tertiary amide groups.
authors: Department of Chemistry and Fujian Provincial Key Laboratory of Chemical Biology, Collaborative Innovation Centre of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, Fujian 361005, P. R. China.
authors: Pei-Qiang
authors: PQ
authors: Huang
authors: Ying-Hong
authors: YH
authors: Huang
authors: Kai-Jiong
authors: KJ
authors: Xiao
authors: Yu
authors: Y
authors: Wang
authors: Xiao-Er
authors: XE
authors: Xia