title: Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades.
abstract: BACKGROUND
  Primary mucinous carcinoma of the skin (PMCS) is a rare adnexal eccrine sweat gland neoplasm, often mistaken for metastasis from extracutaneous sites or misdiagnosed. Primary mucinous carcinoma of the skin is a slow-growing tumor with a high recurrence rate after conventional excision.
  
  
  OBJECTIVE
  To describe clinicopathologic features, rate of recurrence, and metastasis and to review relevant literature.
  
  
  METHODS
  The authors identified patients with PMCS treated from January 1992 through December 2012 at Mayo Clinic. The authors retrospectively reviewed medical records and histology slides. Relevant publications were identified through Ovid MEDLINE and PubMed.
  
  
  RESULTS
  Six patients with PMCS were identified (1 male). The average age at diagnosis was 63 years. Tumor size ranged from 0.5 to 2.0 cm, and all were confined within the dermis. No evidence of metastatic mucinous adenocarcinoma was documented at the time of diagnosis. Five patients underwent Mohs micrographic surgery, and 1 was treated with wide local excision. There were no episodes of recurrence or metastases after a median follow-up of 20 months (range, 0.5-207 months).
  
  
  CONCLUSIONS
  Mohs micrographic surgery may offer reduced recurrence rates and better outcomes in PMCS. Further studies with longer follow-up and bigger cohorts of patients with PMCS are warranted.
authors: *Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota; †Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors: Jessica A
authors: JA
authors: Adefusika
authors: Jason D
authors: JD
authors: Pimentel
authors: Rahul N
authors: RN
authors: Chavan
authors: Jerry D
authors: JD
authors: Brewer
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D012189:Retrospective Studies; D012535:Scalp / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D035441:Thoracic Wall / Q000473:pathology / Q000601:surgery