title: No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis.
abstract: BACKGROUND
  Phospholipid transfer protein (PLTP) is an emerging cardiometabolic risk factor. Plasma PLTP is elevated in humans with end-stage kidney disease and glomerular proteinuria, but the contribution of systemic PLTP elevation to the development of renal damage is unknown. We tested whether human PLTP expression in ApoE deficient mice (an atherosclerosis-prone model) results in renal insufficiency, albuminuria, or glomerulosclerosis.
  
  
  METHODS
  Serum creatinine, albuminuria, as well as kidney and aortic arch histology were determined in 6 male huPLTPtgApoE-/- mice and 8 similarly aged male wild type mice fed a regular chow diet.
  
  
  RESULTS
  huPLTPtgApoE-/- mice (2- to 3-fold elevated PLTP activity) showed marked aortic atherosclerosis. However, serum creatinine (p = 0.11) and albuminuria (p = 0.87) were not increased, whereas renal arteriolar atherosclerosis and glomerulosclerosis were not evident in this PLTP transgenic model.
  
  
  CONCLUSIONS
  High systemic PLTP expression does not contribute significantly to a renal phenotype despite being implicated in systemic atherosclerosis.
authors: Robin P F
authors: RP
authors: Dullaart
authors: Rien
authors: R
authors: Van Haperen
authors: Jaap
authors: J
authors: Van Den Born
authors: Harry
authors: H
authors: Van Goor
authors: Rini
authors: R
authors: De Crom
authors: Arie
authors: A
authors: Van Tol
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism* / Q000473:pathology; D001018:Aortic Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005838:Genotype; D005921:Glomerulonephritis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010641:Phenotype; D049294:Phospholipid Transfer Proteins / Q000235:genetics / Q000378:metabolism*; D011507:Proteinuria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051437:Renal Insufficiency / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D001057:Apolipoproteins E; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins