title: Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.
abstract: OBJECTIVE
  We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA).
  
  
  METHODS
  We performed a meta-analysis on the association between the four gene polymorphisms and RA.
  
  
  RESULTS
  Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR=1.057, 95% CI=0.782-1.429, p=0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR=1.294, 95% CI=1.063-1.576, p=0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR=1.363, 95% CI=1.126-1.651, p=0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR=1.366, 95% CI=1.093-1.707, p=0.006) and in Asians (OR=1.402, 95% CI=1.059-1.855, p=0.014).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address: lyhcgh@korea.ac.kr.
authors: Young Ho
authors: YH
authors: Lee
authors: Division of Rheumatology, Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, South Korea.
authors: Sang-Cheol
authors: SC
authors: Bae
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
authors: Gwan Gyu
authors: GG
authors: Song
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D060908:CTLA-4 Antigen / Q000235:genetics*; D053222:Fas Ligand Protein / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D019014:fas Receptor / Q000235:genetics*; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; D060908:CTLA-4 Antigen; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: CD226; CTLA-4; FAS; Polymorphism; Rheumatoid arthritis