title: Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet-induced obesity.
abstract: Mice with diet-induced obesity were fed with Lactobacillus rhamnosus GG (LGG) suspended in saline or saline alone (control mice). Pulmonary mRNA expression of IFN-γ; IFN-α receptor 1; CD247 antigen; killer cell lectin-like receptor subfamily K, member 1; TNF-α; IL-12 receptor β1 and IL-2 receptor β, and the proportion of Lactobacillales in feces were significantly greater in the LGG group than in the control mice (P < 0.05 and P < 0.01, respectively). These results suggest that LGG alters the respiratory immunity of obese subjects through having a potent impact on intestinal immunity.
authors: Technical Research Laboratory, Takanashi Milk Products, Yokohama, Kanagawa, 241-0023, Japan.
authors: Kenji
authors: K
authors: Miyazawa
authors: Kazutoyo
authors: K
authors: Yoda
authors: Manabu
authors: M
authors: Kawase
authors: Gaku
authors: G
authors: Harata
authors: Fang
authors: F
authors: He
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004032:Diet / Q000379:methods*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000276:immunology*; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000276:immunology*; D011971:Receptors, Immunologic / Q000096:biosynthesis; D012137:Respiratory System / Q000276:immunology*
chemical_list: D016207:Cytokines; D011971:Receptors, Immunologic
keywords: Lactobacillus GG; intestinal microbiota; obesity; respiratory immunity