title: Using exercise to measure and modify cardiac function.
abstract: Exercise is the archetype of physiologic demands placed on the cardiovascular system. Acute responses provide an informative assessment of cardiovascular function and fitness, while repeated exercise promotes cardiovascular health and evokes important molecular, structural, and functional changes contributing to its effects in primary and secondary prevention. Here we examine the use of exercise in murine models, both as a phenotypic assay and as a provocative intervention. We first review the advantages and limitations of exercise testing for assessing cardiac function, then highlight the cardiac structural and cellular changes elicited by chronic exercise and key molecular pathways that mediate these effects.
authors: Cardiovascular Division of the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
authors: Colin
authors: C
authors: Platt
authors: Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115.
authors: Nicholas
authors: N
authors: Houstis
authors: Cardiovascular Division of the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.|Cardiovascular Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115.
authors: Anthony
authors: A
authors: Rosenzweig
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans
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