title: mTOR Links Environmental Signals to T Cell Fate Decisions.
abstract: T cell fate decisions play an integral role in maintaining the health of organisms under homeostatic and inflammatory conditions. The localized microenvironment in which developing and mature T cells reside provides signals that serve essential functions in shaping these fate decisions. These signals are derived from the immune compartment, including antigens, co-stimulation, and cytokines, and other factors, including growth factors and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within the immune microenvironment, is a central regulator of T cell biology. In this review, we discuss how various environmental cues tune mTOR activity in T cells, and summarize how mTOR integrates these signals to influence multiple aspects of T cell biology.
authors: Department of Immunology, St. Jude Children's Research Hospital , Memphis, TN , USA.
authors: Nicole M
authors: NM
authors: Chapman
authors: Department of Immunology, St. Jude Children's Research Hospital , Memphis, TN , USA.
authors: Hongbo
authors: H
authors: Chi
keywords: T cells; Treg cells; iNKT cell; mTOR
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