title: Natural variation in paternal behavior is associated with central estrogen receptor alpha and oxytocin levels.
abstract: In monogamous mammals paternal care plays an important role in the neural and behavioral development of offspring. However, the neuroendocrine mechanisms underlying paternal behavior remain poorly understood. Here, we investigate the association between natural variation in paternal responsiveness and central levels of oxytocin (OT) and estrogen receptor alpha (ERα). We used the frequency of licking and grooming behavior to distinguish low paternal responsiveness and high paternal responsiveness in virgin mandarin voles (Microtus mandarinus). Males that engaged in high paternal behavior had elevated levels of OT immunoreactive neurons in the paraventricular nuclei of the hypothalamus and supraoptic nuclei of the hypothalamus compared with males that displayed low paternal behavior. Likewise, males of high paternal responsiveness had more ERα immunoreactive neurons in the medial preoptic area, bed nucleus of the stria terminalis, arcuate nucleus of the hypothalamus and medial amygdaloid nucleus compared to low responsive males. The level of ERα immunoreactive neurons in the ventromedial hypothalamic nucleus was lower in highly paternal males compared to less paternal males. These results suggest that natural variation in paternal responsiveness may be directly related to variation in central OT and ERα.
authors: Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, 710062, China.
authors: Yani
authors: Y
authors: Li
authors: Zhenmin
authors: Z
authors: Lian
authors: Bo
authors: B
authors: Wang
authors: Fadao
authors: F
authors: Tai
authors: Ruiyong
authors: R
authors: Wu
authors: Ping
authors: P
authors: Hao
authors: Xufeng
authors: X
authors: Qiao
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000378:metabolism*; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006120:Grooming; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010332:Paternal Behavior; D015398:Signal Transduction
chemical_list: D047628:Estrogen Receptor alpha; D010121:Oxytocin
references: Endocrinology. 2003 Nov;144(11):4720-4
references: 12959970
references: Behav Processes. 2009 Nov;82(3):271-8
references: 19635534
references: Horm Behav. 2006 Aug;50(2):338-45
references: 16753164
references: J Med Chem. 1989 Feb;32(2):382-91
references: 2913298
references: Neurosci Biobehav Rev. 2000 Aug;24(6):669-86
references: 10940441
references: Endocrinology. 2007 Oct;148(10):5095-104
references: 17628000
references: Psychoneuroendocrinology. 1994;19(5-7):543-52
references: 7938353
references: Front Behav Neurosci. 2009 Aug 27;3:17
references: 19753327
references: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5335-40
references: 9560276
references: Psychoneuroendocrinology. 2010 Sep;35(8):1133-41
references: 20153585
references: J Comp Physiol Psychol. 1977 Feb;91(1):146-64
references: 402400
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Apr;197(4):329-37
references: 21225271
references: Physiol Behav. 1985 Sep;35(3):417-25
references: 2999841
references: Behav Brain Res. 2012 May 16;231(1):86-91
references: 22409973
references: Physiol Behav. 1989 May;45(5):1033-41
references: 2780864
references: Brain Res. 1980 Aug 4;194(2):471-8
references: 7388622
references: Horm Behav. 1996 Sep;30(3):201-15
references: 8918676
references: Horm Behav. 2006 May;49(5):681-7
references: 16442534
references: Horm Behav. 2006 Dec;50(5):699-707
references: 16934808
references: Horm Behav. 2012 May;61(5):669-77
references: 22421629
references: J Neuroendocrinol. 2000 Jan;12(1):5-12
references: 10692138
references: Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R53-8
references: 16832906
references: Horm Behav. 2004 Jun;46(1):30-8
references: 15215039
references: Physiol Behav. 2003 Aug;79(3):359-71
references: 12954431
references: J Comp Physiol Psychol. 1974 Oct;87(4):746-59
references: 4426995
references: Horm Behav. 1998 Feb;33(1):23-30
references: 9571010
references: Dev Psychobiol. 2007 Jan;49(1):12-21
references: 17186513
references: Dev Psychobiol. 2001 Jan;38(1):11-32
references: 11150058
references: Behav Brain Res. 2010 Dec 25;214(2):290-300
references: 20678985
references: Horm Behav. 2004 May;45(5):354-61
references: 15109910
references: Nat Genet. 1995 Jan;9(1):12-3
references: 7704015
references: Physiol Behav. 2003 Nov;80(2-3):233-41
references: 14637221
references: Brain Res. 1993 Dec 17;631(1):156-60
references: 8298988
references: Exp Brain Res. 1989;76(3):593-602
references: 2792248
references: Behav Neurosci. 1987 Jun;101(3):439-41
references: 3606816
references: PLoS One. 2010 Jan 27;5(1):e8931
references: 20111713
references: Brain Res. 2006 Oct 20;1116(1):58-63
references: 16945352
references: Ann N Y Acad Sci. 1997 Jan 15;807:287-301
references: 9071358
references: J Neurosci. 2008 Oct 8;28(41):10399-403
references: 18842899
references: Neuroendocrinology. 1993 Dec;58(6):637-45
references: 8127393
references: Ann N Y Acad Sci. 1992 Jun 12;652:357-73
references: 1320831
references: Neuroscience. 1993 Mar;53(1):65-75
references: 8469313
references: Behav Processes. 2004 May 31;66(2):107-17
references: 15110913
references: Behav Neurosci. 2001 Dec;115(6):1341-8
references: 11770064
references: Physiol Behav. 1990 May;47(5):993-1011
references: 2388953
references: Physiol Behav. 2013 Mar 15;112-113:14-22
references: 23438372
references: Proc Biol Sci. 2002 Apr 22;269(1493):823-9
references: 11958714
references: Horm Behav. 2012 Mar;61(3):293-303
references: 22100184
references: Pharmacol Biochem Behav. 1990 Sep;37(1):63-9
references: 2263668
references: J Neuroendocrinol. 2010 May;22(5):420-9
references: 20163514
references: Neuroscience. 2006 Aug 25;141(2):559-68
references: 16725274
references: Front Neuroendocrinol. 2007 Aug-Sep;28(2-3):115-41
references: 17604088
references: J Endocrinol. 1987 Feb;112(2):275-82
references: 3819639
references: Prog Brain Res. 2008;170:155-66
references: 18655880
references: Brain Res. 1994 Sep 26;658(1-2):112-8
references: 7834331
references: Ann N Y Acad Sci. 1997 Jan 15;807:273-86
references: 9071357
references: Neuroscience. 2006 Sep 29;142(1):165-73
references: 16876954
references: Behav Neurosci. 1995 Feb;109(1):135-49
references: 7734069
references: Behav Neurosci. 1984 Aug;98(4):703-11
references: 6540591
references: J Neuroendocrinol. 1989 Aug 1;1(4):273-8
references: 19210440
references: Behav Neurosci. 1988 Jun;102(3):381-96
references: 3395448
references: Behav Neurosci. 1999 Oct;113(5):1071-9
references: 10571489
references: Front Neuroendocrinol. 2009 Jan;30(1):46-64
references: 19022278
references: J Neuroendocrinol. 2012 Jun;24(6):874-86
references: 22356098
references: J Neuroendocrinol. 2002 May;14(5):349-53
references: 12000539
references: Behav Brain Res. 2011 Oct 31;224(2):279-89
references: 21684307
references: Physiol Behav. 2006 Feb 28;87(2):424-9
references: 16360186
references: Pharmacol Biochem Behav. 1992 Nov;43(3):855-61
references: 1448480
references: Science. 1997 Sep 12;277(5332):1659-62
references: 9287218
references: Anim Behav. 1998 May;55(5):1131-40
references: 9632499
references: Endocrinology. 1998 Dec;139(12):5058-69
references: 9832445
references: J Neurosci. 2005 Jul 20;25(29):6807-15
references: 16033890