title: [Intravenous vinorelbine as first line chemotherapy in patients with castration-resistant prostate cancer].
abstract: BACKGROUND
  Docetaxel-based chemotherapy remains the treatment of choice in castration-resistant prostate cancer (CRPC). Generally, elderly patients poorly tolerate these drugs. Vinorelbine has a favolable toxicity profile and may be useful in elderly or unfit patients with castration-resistant prostate cancer.
  
  
  OBJECTIVE
  The aim of this retrospective analysis was to evaluate the efficacy and safety of vinorelbine in patients with CRPC.
  
  
  METHODS
  We analyzed the medical records of patients with CRPC treated in our institution with intravenous vinorelbine as first line chemotherapy.
  
  
  RESULTS
  A total of 25 patients were assessable for efficacy. The median age was 73 years (range, 51-87 years); 9 out of 25 patients (36%) had a > 50% reduction in PSA levels from baseline. Mean progression-free survival was 7.2 months. Mean overall survival was 20.7 months. Mean overall survival for 11 patients treated with second-line taxane-based chemotherapy was 27.5 months compared to 16.8 months for patients who did not receive second-line chemotherapy. Treatment was generally well tolerated.
  
  
  CONCLUSIONS
  On the basis of this small retrospective survey, we conclude that intravenous vinorelbine seems to be a therapeutic option in elderly or unfit patients with CRPC.
authors: Tal
authors: T
authors: Grenader
authors: Yevgeni
authors: Y
authors: Plotkin
authors: Ora
authors: O
authors: Rosengarten
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000369:Aged, 80 and over; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D064129:Prostatic Neoplasms, Castration-Resistant / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D017430:Prostate-Specific Antigen; D000077235:Vinorelbine