title: Urine proteomic studies in preeclampsia.
abstract: Preeclampsia (PE) is a multisystem disorder of pregnancy that develops after 20 wk of gestation in previously normotensive women and complicates 5-8% of pregnancies. This rapidly progressive syndrome is usually diagnosed when the mother develops hypertension and proteinuria. The only effective treatment is delivery of the baby although early low-dose aspirin has been shown to significantly reduce the risk for PE. Recent advances in proteomic methods of protein separation, identification, and quantitation may allow for the identification of proteins and peptides that could facilitate early detection of disease, improve assessment of prognosis, and allow closer monitoring of women at risk for PE. This review summarizes all currently available markers for prediction and diagnosis of PE and presents urine proteomic studies performed for the identification of novel biomarkers.
authors: Department of Medical Genetics, Athens University School of Medicine, Athens, Greece.
authors: Aggeliki
authors: A
authors: Kolialexi
authors: Department of Medical Genetics, Athens University School of Medicine, Athens, Greece.
authors: Danai
authors: D
authors: Mavreli
authors: Department of Medical Genetics, Athens University School of Medicine, Athens, Greece.
authors: Georgia
authors: G
authors: Tounta
authors: Department of Medical Genetics, Athens University School of Medicine, Athens, Greece.
authors: Ariadni
authors: A
authors: Mavrou
authors: 3rd Department of Obstetrics & Gynecology, Athens University School of Medicine, Athens, Greece.
authors: Nikolas
authors: N
authors: Papantoniou
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000652:urine*; D011247:Pregnancy; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis / Q000652:urine*; D020543:Proteome / Q000378:metabolism; D040901:Proteomics; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Biomarkers; Preeclampsia; Urine proteomics