title: Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe.
abstract: Retrieving the names of friends, loved ones, and famous people is a fundamental human ability. This ability depends on the left anterior temporal lobe (ATL), where lesions can be associated with impaired naming of people regardless of modality (e.g., picture or voice). This finding has led to the idea that the left ATL is a modality-independent convergence region for proper naming. Hypotheses for how proper-name dispositions are organized within the left ATL include both a single modality-independent (heteromodal) convergence region and spatially discrete modality-dependent (unimodal) regions. Here we show direct electrophysiologic evidence that the left ATL is heteromodal for proper-name retrieval. Using intracranial recordings placed directly on the surface of the left ATL in human subjects, we demonstrate nearly identical responses to picture and voice stimuli of famous U.S. politicians during a naming task. Our results demonstrate convergent and robust large-scale neurophysiologic responses to picture and voice naming in the human left ATL. This finding supports the idea of heteromodal (i.e., transmodal) dispositions for proper naming in the left ATL.
authors: Department of Neurosurgery and taylor-abel@uiowa.edu.
authors: Taylor J
authors: TJ
authors: Abel
authors: Department of Neurosurgery and.
authors: Ariane E
authors: http://orcid.org/0000-0002-5699-8733
authors: AE
authors: Rhone
authors: Department of Neurosurgery and.
authors: Kirill V
authors: KV
authors: Nourski
authors: Department of Neurosurgery and.
authors: Hiroto
authors: H
authors: Kawasaki
authors: Department of Neurosurgery and.
authors: Hiroyuki
authors: H
authors: Oya
authors: Newcastle Auditory Group, Medical School, Newcastle University, Newcastle-upon-Tyne NE1 7RU, United Kingdom.
authors: Timothy D
authors: TD
authors: Griffiths
authors: Department of Neurosurgery and.
authors: Matthew A
authors: MA
authors: Howard
authors: Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, and.
authors: Daniel
authors: D
authors: Tranel
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012660:Semantics; D013057:Spectrum Analysis; D013702:Temporal Lobe / Q000502:physiology*
keywords: electrocorticography; language; naming; temporal pole
references: Hum Brain Mapp. 2001 Aug;13(4):199-212
references: 11410949
references: Neuropsychologia. 2010 Apr;48(5):1336-42
references: 20038436
references: J Cogn Neurosci. 2005 Aug;17(8):1293-305
references: 16197684
references: J Comp Neurol. 1987 Feb 1;256(1):88-103
references: 3819040
references: Neuroimage. 1997 Oct;6(3):156-67
references: 9344820
references: Electroencephalogr Clin Neurophysiol. 1997 Apr;102(4):316-25
references: 9146493
references: Nature. 1996 Apr 11;380(6574):499-505
references: 8606767
references: Trends Cogn Sci. 2010 Nov;14(11):506-15
references: 20932795
references: Brain. 1998 Nov;121 (Pt 11):2103-18
references: 9827770
references: J Neurosci. 2007 Feb 28;27(9):2424-32
references: 17329441
references: Hum Brain Mapp. 2007 Dec;28(12):1368-75
references: 17274021
references: J Neurosurg Pediatr. 2011 May;7(5):482-90
references: 21529188
references: Cereb Cortex. 2011 Oct;21(10):2332-47
references: 21368087
references: J Cogn Neurosci. 2001 Apr 1;13(3):341-56
references: 11371312
references: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20137-41
references: 18056637
references: Cognition. 2004 May-Jun;92(1-2):179-229
references: 15037130
references: Neuroimage. 2014 Jan 15;85 Pt 2:738-48
references: 23891904
references: Front Biosci (Schol Ed). 2014;6:50-7
references: 24389260
references: Trends Cogn Sci. 2003 Feb;7(2):84-91
references: 12584027
references: Brain. 1998 Dec;121 ( Pt 12):2301-15
references: 9874481
references: Cereb Cortex. 2012 Sep;22(9):2005-15
references: 22021913
references: Neuropsychologia. 2010 May;48(6):1689-96
references: 20176043
references: J Neurosci. 2001 Oct 15;21(20):RC177
references: 11588207
references: Neuroimage. 2013 Apr 1;69:267-76
references: 23274183
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: Physiol Meas. 2014 Mar;35(3):323-37
references: 24480831
references: Neuropsychology. 2014 May;28(3):429-35
references: 24364392
references: J Cogn Neurosci. 2010 Jun;22(6):1083-94
references: 19583477
references: PLoS One. 2008;3(12):e3892
references: 19065268
references: Neuroimage. 2000 Jun;11(6 Pt 1):589-600
references: 10860788
references: J Neurosci. 2011 Dec 7;31(49):18119-29
references: 22159123
references: Brain Res. 2011 Aug 17;1407:13-26
references: 21420393
references: J Neurosurg. 2007 Jun;106(6):1117-33
references: 17564192
references: J Cogn Neurosci. 2012 Oct;24(10):1998-2014
references: 22721379
references: Cortex. 2013 Jun;49(6):1648-67
references: 23040175
references: Philos Trans R Soc Lond B Biol Sci. 2014;369(1634):20120392
references: 24324236
references: Curr Biol. 2010 May 25;20(10):964-8
references: 20451381
references: J Comp Neurol. 2003 Oct 27;465(4):499-523
references: 12975812
references: Neuropsychologia. 2011 Oct;49(12):3419-29
references: 21889520
references: J Neurosci. 2011 Sep 7;31(36):12855-65
references: 21900564
references: Neuropsychologia. 1997 Oct;35(10):1319-27
references: 9347478
references: Brain. 2008 Aug;131(Pt 8):2013-27
references: 18669510