title: Republished: Non-alcoholic fatty liver disease: a practical approach to treatment.
abstract: Non-alcoholic fatty liver disease (NAFLD) affects up to a third of the population in many developed countries. Between 10% and 30% of patients with NAFLD have non-alcoholic steatohepatitis (NASH) that can progress to cirrhosis. There are metabolic risk factors common to both NAFLD and cardiovascular disease, so patients with NASH have an increased risk of liver-related and cardiovascular death. Management of patients with NAFLD depends largely on the stage of disease, emphasising the importance of careful risk stratification. There are four main areas to focus on when thinking about management strategies in NAFLD: lifestyle modification, targeting the components of the metabolic syndrome, liver-directed pharmacotherapy for high risk patients and managing the complications of cirrhosis.
authors: Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
authors: J K
authors: JK
authors: Dyson
authors: Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
authors: Q M
authors: QM
authors: Anstee
authors: Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
authors: S
authors: S
authors: McPherson
keywords: Chronic Liver Disease; Fatty Liver; Hepatic Fibrosis; Nonalcoholic Steatohepatitis; Obesity
references: Hepatology. 2011 Mar;53(3):1020-2
references: 21374666
references: Hepatology. 2003 Apr;37(4):917-23
references: 12668987
references: Liver Transpl. 2009 Dec;15(12):1843-51
references: 19938117
references: Gastroenterology. 2001 Jul;121(1):91-100
references: 11438497
references: N Engl J Med. 2003 Apr 24;348(17):1625-38
references: 12711737
references: J Ultrasound Med. 2001 Feb;20(2):99-104
references: 11211142
references: Gut. 2012 Apr;61(4):484-500
references: 22234978
references: J Hepatol. 2012 Jan;56(1):255-66
references: 21723839
references: Clin Gastroenterol Hepatol. 2008 Dec;6(12):1396-402
references: 18986848
references: Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E151-6
references: 19383872
references: J Hepatol. 2010 Aug;53(2):372-84
references: 20494470
references: Hepatology. 2007 Sep;46(3):922-38
references: 17879356
references: Hepatology. 2009 Jan;49(1):80-6
references: 19053049
references: Circulation. 1998 Feb 24;97(7):661-5
references: 9495301
references: Gut. 2002 Feb;50 Suppl 1:i1-9
references: 11788576
references: Cardiol J. 2010;17(5):448-56
references: 20865674
references: N Engl J Med. 2004 Dec 23;351(26):2683-93
references: 15616203
references: World J Hepatol. 2012 Dec 27;4(12):327-31
references: 23355909
references: Am J Gastroenterol. 2011 May;106(5):894-8
references: 21157439
references: J Appl Physiol (1985). 2011 Dec;111(6):1554-60
references: 21868679
references: Anesthesiology. 2008 May;108(5):812-21
references: 18431116
references: J Hepatol. 2012 Apr;56(4):944-51
references: 22023985
references: Lancet. 1998 Sep 12;352(9131):854-65
references: 9742977
references: Gut. 2012 Mar;61(3):409-15
references: 21846782
references: Hepatology. 2005 Jul;42(1):44-52
references: 15895401
references: Liver Transpl. 2010 Apr;16(4):431-9
references: 20373454
references: Aliment Pharmacol Ther. 2013 Jan;37(2):234-42
references: 23163663
references: Am J Clin Nutr. 2007 Sep;86(3):s836-42
references: 18265477
references: Hepatology. 2010 Jun;51(6):1972-8
references: 20209604
references: Hepatology. 2008 Dec;48(6):1791-8
references: 18972405
references: BMJ. 2010;341:c5702
references: 21051774
references: Gastroenterology. 2013 Feb;144(2):323-32
references: 23063971
references: N Engl J Med. 2006 Nov 30;355(22):2297-307
references: 17135584
references: Diabetes Care. 2007 Mar;30(3):683-8
references: 17327341
references: Arch Intern Med. 2001 Nov 26;161(21):2564-70
references: 11718587
references: Mol Cells. 2013 Oct;36(4):279-87
references: 23794020
references: Cancer Res. 2004 Sep 15;64(18):6461-8
references: 15374955
references: Gastroenterology. 2008 Oct;135(4):1176-84
references: 18718471
references: BMJ. 2011;343:d3897
references: 21768191
references: Am J Clin Nutr. 2009 Feb;89(2):558-67
references: 19141695
references: Aliment Pharmacol Ther. 2012 Jan;35(1):66-75
references: 22050199
references: Recent Results Cancer Res. 2009;181:51-4
references: 19213556
references: Gastroenterology. 2009 Aug;137(2):532-40
references: 19409898
references: Hepatology. 2010 Jan;51(1):121-9
references: 19827166
references: Cancer. 2010 Apr 15;116(8):1938-46
references: 20166205
references: Frontline Gastroenterol. 2014 Jul;5(3):211-218
references: 25018867
references: J Clin Invest. 2001 Oct;108(8):1167-74
references: 11602624
references: Diabetes Care. 2013 Jul;36(7):2126-32
references: 23645884
references: Lancet. 2007 Sep 29;370(9593):1129-36
references: 17905165
references: Hepatology. 2006 Oct;44(4):865-73
references: 17006923
references: Gastroenterology. 1999 Jun;116(6):1413-9
references: 10348825
references: Nat Rev Cancer. 2005 Dec;5(12):930-42
references: 16341084
references: N Engl J Med. 2010 May 6;362(18):1675-85
references: 20427778
references: Gut. 2000 Jun;46 Suppl 3-4:III1-III15
references: 10862604
references: Gastroenterology. 2003 Jul;125(1):117-25
references: 12851877
references: Nature. 2004 Oct 28;431(7012):1112-7
references: 15475948
references: Obes Rev. 2013 May;14(5):417-31
references: 23387384
references: Liver Transpl. 2008 Jun;14(6):881-5
references: 18508357
references: Hepatology. 2004 Dec;40(6):1387-95
references: 15565570
references: BMJ. 2000 Aug 12;321(7258):405-12
references: 10938048
references: Lancet. 2010 Dec 4;376(9756):1916-22
references: 21109302
references: J Endocrinol Invest. 2012 Feb;35(2):231-5
references: 22490993
references: Clin Gastroenterol Hepatol. 2011 Oct;9(10):897-901
references: 21782772
references: Gastroenterology. 2011 Jan;140(1):124-31
references: 20858492
references: Gastroenterology. 2011 Oct;141(4):1249-53
references: 21726509
references: Diabetes Care. 2011 Jun;34(6):1369-71
references: 21515844
references: Ann Intern Med. 2005 Jan 4;142(1):37-46
references: 15537682
references: J Gastroenterol. 2009;44(12):1190-4
references: 19672551
references: Gut. 2011 Sep;60(9):1278-83
references: 21708823
references: Gut. 2010 Sep;59(9):1265-9
references: 20801772
references: Hepatology. 1990 Nov;12(5):1106-10
references: 2227807
references: World J Gastroenterol. 2009 May 28;15(20):2506-11
references: 19469001
references: Surg Obes Relat Dis. 2013 Jan-Feb;9(1):1-6
references: 23201210
references: Clin Gastroenterol Hepatol. 2006 May;4(5):639-44
references: 16630771
references: JAMA. 2011 Apr 27;305(16):1659-68
references: 21521847
references: J Hepatol. 2003 Dec;39(6):1076-84
references: 14642630
references: Gastroenterology. 2012 Jun;142(7):1592-609
references: 22656328
references: Am J Clin Nutr. 2007 Aug;86(2):285-300
references: 17684197
references: JAMA. 2007 Sep 12;298(10):1180-8
references: 17848652
references: J Hepatol. 2013 Jul;59(1):138-43
references: 23485520
references: N Engl J Med. 2007 Aug 23;357(8):741-52
references: 17715408
references: Lancet. 2005 Oct 8;366(9493):1267-78
references: 16214597
references: Gastroenterology. 2009 May;136(5):1601-8
references: 19208359
references: World J Gastroenterol. 2009 Feb 28;15(8):942-54
references: 19248193
references: Curr Osteoporos Rep. 2010 Dec;8(4):178-84
references: 20809203
references: J Hepatol. 2013 Sep;59(3):536-42
references: 23623998
references: Cancer Res. 2011 Mar 15;71(6):2286-97
references: 21262914
references: JAMA. 2009 Jan 7;301(1):39-51
references: 19066370
references: Med Sci Sports Exerc. 2010 Nov;42(11):1973-80
references: 20351587
references: J Natl Cancer Inst. 2009 Jan 7;101(1):48-60
references: 19116382
references: Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):330-44
references: 23507799
references: Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G825-34
references: 21836057
references: J Hepatol. 2012 Apr;56(4):908-43
references: 22424438
references: Eur J Gastroenterol Hepatol. 2013 Jun;25(6):652-8
references: 23325287
references: Gut. 2013 Apr;62(4):606-15
references: 22773548
references: Cochrane Database Syst Rev. 2010;(1):CD007340
references: 20091629