title: Evaluation of antidepressant polypharmacy and other interventions for treatment-resistant depression.
abstract: There is on-going controversy about the definition and sub-classification of treatment-resistant depression (TRD) that makes it difficult to assess the effectiveness of different proposed strategies for treating this chronic, often disabling condition. Sub-classification of TRD in terms of symptom severity and in terms of demographic and clinical characteristics may help in the recognition of homogeneous TRD subgroups and in the development of subgroup-specific interventions.
authors: Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Daihui
authors: D
authors: Peng
authors: Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Yiru
authors: Y
authors: Fang
keywords: adjunctive treatment; classification; combined treatment; treatment-resistant depression
references: Lancet. 2013 Jun 8;381(9882):1987-2015
references: 23746901
references: Biol Psychiatry. 2003 Apr 15;53(8):649-59
references: 12706951
references: Expert Rev Neurother. 2008 Sep;8(9):1299-306
references: 18759541
references: J Clin Psychiatry. 1997;58 Suppl 13:23-9
references: 9402916
references: J Clin Psychiatry. 2002 Feb;63(2):95-103
references: 11874227
references: Nat Med. 1998 Nov;4(11):1241-3
references: 9809543
references: J Clin Psychopharmacol. 2005 Aug;25(4):336-41
references: 16012276
references: Aust N Z J Psychiatry. 2002 Jun;36(3):384-91
references: 12060188