title: Cytotoxicity of benzophenanthridine alkaloids from the roots of Zanthoxylum nitidum (Roxb.) DC. var. fastuosum How ex Huang.
abstract: This work aimed to investigate benzophenanthridine from the roots of Zanthoxylum nitidum (Roxb.) DC. var. fastuosum How ex Huang for the first time. Thirteen benzophenanthridines were isolated, and our results of the cytotoxic activities indicated that compound 6 exhibited the best potency against A549, Hela, SMMC-7721 and EJ, with the IC50 values of 27.50, 37.50, 16.95 and 60.42 μM, respectively. Compounds 7 and 11 also showed strong cytotoxicity when tested against the four human cancer cell lines (A549, Hela, SMMC-7721 and EJ), while only compounds 12 and 13 displayed cytotoxicity in inhibiting BALL-1 proliferation among all the compounds. These results suggested that benzophenanthridines may become a valid alternative of potential basis for new anti-proliferative agents.
authors: a China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention , Xicheng District, Beijing 100088 , P.R. China.
authors: Cheng-Fang
authors: CF
authors: Wang
authors: Li
authors: L
authors: Fan
authors: Mei
authors: M
authors: Tian
authors: Shu-Shan
authors: SS
authors: Du
authors: Zhi-Wei
authors: ZW
authors: Deng
authors: Jiang-Bin
authors: JB
authors: Feng
authors: Yong-Yan
authors: YY
authors: Wang
authors: Xu
authors: X
authors: Su
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D053119:Benzophenanthridines / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines
keywords: Zanthoxylum nitidum (Roxb.) DC. var. fastuosum How ex Huang; benzophenanthridine alkaloids; cytotoxic activity