title: Effect of Aging in the Perception of Health-Related Quality of Life in End-Stage Renal Disease Patients under Online-Hemodiafiltration.
abstract: This work aimed to evaluate how aging could influence patients' perception of health quality of life (HRQOL), as well as, the effect of aging on dialysis adequacy and in hematological, iron status, inflammatory and nutritional markers. In this transversal study were enrolled 305 ESRD patients under online-hemodiafiltration (OL-HDF) (59.67% males; 64.9 ± 14.3 years old). Data about comorbidities, hematological data, iron status, dialysis adequacy, nutritional and inflammatory markers were collected from patient's records. Moreover, HRQOL score, by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), was assessed. Analyzing the results according to quartiles of age, significant differences were found for some parameters evaluated by the KDQOL-SF instrument, namely for work status, physical functioning and role-physical, which decreased with increasing age. We also found a higher proportion of diabetic patients, a decrease in creatinine, iron, albumin serum levels, transferrin saturation and nPCR, with increasing age. Moreover, significant negative correlations were found between age and mean cell hemoglobin concentration, iron, transferrin saturation, albumin, nPCR, work status, physical functioning and role-physical. In conclusion, our results showed that aging is associated with a decreased work status, physical functioning and role-physical, with a decreased dialysis adequacy, iron availability and nutritional status, and with an increased proportion of diabetic patients and of patients using central venous catheter, as the vascular access. The knowledge of these changes associated with aging, which have impact in the quality of life of the patients, could be useful in their management.
authors: Instituto de Ciências da Saúde, Universidade Católica Portuguesa, Porto, Portugal.
authors: Alexandra
authors: A
authors: Moura
authors: Clínica de Hemodiálise NefroServe, Barcelos, Portugal.
authors: José
authors: J
authors: Madureira
authors: Clínica de Hemodiálise NefroServe, Barcelos, Portugal.
authors: Pablo
authors: P
authors: Alija
authors: Clínica de Hemodiálise NefroServe, Viana do Castelo, Portugal.
authors: João Carlos
authors: JC
authors: Fernandes
authors: Centro Hospitalar do Porto, Porto, Portugal.
authors: José Gerardo
authors: JG
authors: Oliveira
authors: Clínica de Hemodiálise de Felgueira, Felgueiras, Portugal.
authors: Martin
authors: M
authors: Lopez
authors: Clínica de Hemodiálise de Gondomar, Gondomar, Portugal.
authors: Madalena
authors: M
authors: Filgueiras
authors: Clínica de Hemodiálise NephroCare, Maia, Portugal.
authors: Leonilde
authors: L
authors: Amado
authors: Clínica de Hemodiálise NephroCare, Maia, Portugal.
authors: Maria
authors: M
authors: Sameiro-Faria
authors: Clínica de Hemodiálise NephroCare, Maia, Portugal.
authors: Vasco
authors: V
authors: Miranda
authors: Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal ; Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.
authors: Alice
authors: A
authors: Santos-Silva
authors: Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal ; Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.
authors: Elísio
authors: E
authors: Costa
keywords: Health-related quality of life; aging; dialysis adequacy; gender; iron availability; nutritional status; on-line hemodiafiltration
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