title: Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.
abstract: To investigate whether exercise training can reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles, young (4 mo) and old (22 mo) male Fischer 344 rats were randomly assigned to either sedentary or exercise-trained groups. The roles of the endothelium and Kv1 channels in age- and exercise training-induced adaptations of myogenic responses were assessed through evaluation of pressure-induced constriction in endothelium-intact and denuded soleus muscle arterioles in the presence and absence of the Kv1 channel blocker, correolide. Exercise training enhanced myogenic constriction in arterioles from both old and young rats. In arterioles from old rats, exercise training restored myogenic constriction to a level similar to that of arterioles from young sedentary rats. Removal of the endothelium did not alter myogenic constriction of arterioles from young sedentary rats, but reduced myogenic constriction in arterioles from young exercise-trained rats. In contrast, endothelial removal had no effect on myogenic constriction of arterioles from old exercise-trained rats, but increased myogenic vasoconstriction in old sedentary rats. The effect of Kv1 channel blockade was also dependent on age and training status. In arterioles from young sedentary rats, Kv1 blockade had little effect on myogenic constriction, whereas in old sedentary rats Kv1 blockade increased myogenic constriction. After exercise training, Kv1 channel blockade increased myogenic constriction in arterioles from both young and old rats. Thus exercise training restores myogenic constriction of arterioles from old rats and enhances myogenic constriction from young rats through adaptations of the endothelium and smooth muscle Kv1 channels.
authors: Departments of Applied Physiology and Kinesiology and.
authors: Payal
authors: P
authors: Ghosh
authors: Departments of Applied Physiology and Kinesiology and.
authors: Fredy R
authors: FR
authors: Mora Solis
authors: Pharmacology and Therapeutics, University of Florida, Gainesville, Florida;
authors: James M
authors: JM
authors: Dominguez
authors: Department of Health and Kinesiology, University of Texas at Tyler, Texas;
authors: Scott A
authors: SA
authors: Spier
authors: Department of Internal Medicine and Veteran's Affairs Medical Center, Geriatrics Research Education and Clinical Center, University of Utah, Salt Lake City, Utah;
authors: Anthony J
authors: AJ
authors: Donato
authors: Department of Nutrition, Food and Exercise Sciences, and the Center for Advancing Exercise and Nutrition Research on Aging, Florida State University, Tallahassee, Florida; and.
authors: Michael D
authors: MD
authors: Delp
authors: Department of Biomedical Sciences, Florida State University College of Medicine, Florida State University, Tallahassee, Florida judy.delp@med.fsu.edu.
authors: Judy M
authors: JM
authors: Muller-Delp
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001160:Arterioles / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D014661:Vasoconstriction / Q000502:physiology*
keywords: correolide; endothelium; myogenic
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