title: Efficiency of sepiolite in broilers diet as uranium adsorbent.
abstract: The use of phosphate mineral products in animal nutrition, as a major source of phosphor and calcium, can lead to uranium entering the food chain. The aim of the present study was to determine the protective effect of natural sepiolite and sepiolite treated with acid for broilers after oral intake of uranium. The broilers were contaminated for 7 days with 25 mg/uranyl nitrate per day. Two different adsorbents (natural sepiolite and sepiolite treated with acid) were given via gastric tube immediately after the oral administration of uranium. Natural sepiolite reduced uranium distribution by 57% in kidney, 80% in liver, 42% in brain, and 56% in muscle. A lower protective effect was observed after the administration of sepiolite treated with acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and necrosis, and histopathological lesions on kidney in the form of edema and abruption of epithelial cells in tubules. When broilers received only sepiolite treated with acid (no uranyl nitrate), shortening of intestinal villi occurred. Kidney injuries were evident when uranium concentrations in kidney were 0.88 and 1.25 µg/g dry weight. It is concluded that adding of natural sepiolite to the diets of broilers can reduce uranium distribution in organs by significant amount without adverse side effects.
authors: Department of Radiology and Radiation Hygiene, Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobodjenja 18, 11000, Belgrade, Serbia, slavatab@vet.bg.ac.rs.
authors: Branislava M
authors: BM
authors: Mitrović
authors: Milijan
authors: M
authors: Jovanović
authors: Mirjana
authors: M
authors: Lazarević-Macanović
authors: Djordje
authors: D
authors: Janaćković
authors: Nikola
authors: N
authors: Krstić
authors: Mirjana
authors: M
authors: Stojanović
authors: Milorad
authors: M
authors: Mirilović
mesh_terms: D000327:Adsorption; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002645:Chickens; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000378:metabolism; D017633:Magnesium Silicates / Q000737:chemistry*; D013997:Time Factors; D014501:Uranium / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000633:toxicity; D014502:Uranyl Nitrate / Q000737:chemistry
chemical_list: D017633:Magnesium Silicates; D014502:Uranyl Nitrate; D014501:Uranium; C001671:magnesium trisilicate
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