title: Tonic pupil in leprosy.
abstract: Pupil abnormalities in leprosy usually result from chronic iritis with loss of stroma, iris miosis, a sluggish reaction to light, and poor dilation in response to anticholinergic mydriatics. We report two patients with long-standing lepromatous leprosy who developed tonic pupils characterized by mydriasis, absence of reaction to light and hypersensitivity to weak cholinergic solution. Examination revealed iritis and iris atrophy. In both cases, instillation of dilute 0.1% pilocarpine caused miosis in the affected eyes. Tonic pupil occurs in many conditions, but its association with leprosy had not been previously reported.
authors: Department of Ophthalmology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors: Marco Aurélio
authors: MA
authors: Lana-Peixoto
authors: Department of Ophthalmology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors: Wesley Ribeiro
authors: WR
authors: Campos
authors: Department of Ophthalmology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors: Pedro Augusto Costa
authors: PA
authors: Reis
authors: Department of Ophthalmology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors: Christian Marcellus Camargo
authors: CM
authors: Campos
authors: aff02.
authors: Carlos Alberto
authors: CA
authors: Rodrigues
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015440:Leprosy, Lepromatous / Q000150:complications*; D015877:Miosis / Q000139:chemically induced; D008916:Miotics / Q000627:therapeutic use; D010862:Pilocarpine / Q000627:therapeutic use; D015845:Tonic Pupil / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D008916:Miotics; D010862:Pilocarpine