title: Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.
abstract: Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.
authors: Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Republic of Korea.
authors: Ki Moo
authors: KM
authors: Lim
authors: Seung-Bae
authors: SB
authors: Hong
authors: Byong Kwon
authors: BK
authors: Lee
authors: Eun Bo
authors: EB
authors: Shim
authors: Natalia
authors: N
authors: Trayanova
mesh_terms: D000818:Animals; D001022:Aortic Valve Insufficiency / Q000503:physiopathology*; D004285:Dogs; D006333:Heart Failure / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D008954:Models, Biological; D013318:Stroke Volume / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology
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