title: Palladium-catalysed carbonylative α-arylation of nitromethane.
abstract: A simple and mild Pd-catalysed carbonylative α-arylation of nitromethane has been realised providing access to α-nitro aryl ketones from an array of aryl and heteroaryl iodides. The methodology requires only a mild base and uses the convenient solid CO releasing molecule, COgen in a two-chamber system. Changing to the isotopically labelled (13)COgen, [(13)C]-acyl labelling can be effected through the generation of a near stoichiometric amount of (13)CO. Lastly, the significance of the generated products as synthetic intermediates is demonstrated.
authors: Carbon Dioxide Activation Centre (CADIAC), Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark. ts@chem.au.dk.
authors: Zhong
authors: Z
authors: Lian
authors: Stig D
authors: SD
authors: Friis
authors: Troels
authors: T
authors: Skrydstrup
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009595:Nitroparaffins / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D007659:Ketones; D009595:Nitroparaffins; D010165:Palladium; D008697:Methane; C008640:nitromethane