title: Effects of ukrain in rats with intestinal ischemia and reperfusion.
abstract: BACKGROUND
  The purpose of this study is to investigate the potential protective effect of the ukrain on ischemia-reperfusion (IR) injury in rat intestine, which has not previously been studied.
  
  
  METHODS
  Thirty-one male Sprague-Dawley rats were randomly assigned to four groups, each consisting of eight rats as follows: (1) a sham group (S) (laparotomy, but no IR injury); (2) ukrain group (U) (no IR, and ukrain was administered intraperitoneally 1 h before laparotomy); (3) intestinal ischemia-reperfusion (II/R) group (30-min occlusion of the superior mesenteric artery then 2-h reperfusion); and (4) ukrain + II/R group (U + II/R) (30-min occlusion of the superior mesenteric artery then 2-h reperfusion; ukrain was administered intraperitoneally 1 h before IR).
  
  
  RESULTS
  Serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using Erel method. Oxidative stress index was calculated using the TOS/TAS ratio. TAS levels increased and TOS serum levels were also significantly decreased in the ukrain + IR group compared with the IR group (P = 0.000 and P = 0.015).
  
  
  CONCLUSIONS
  In this study, we demonstrated for the first time in literature that ukrain helps to prevent intestinal tissue breakdown against II/R injury and that this effect can be achieved by antioxidant activities.
authors: Department of Physiology, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey. Electronic address: raziyeakcilar@gmail.com.
authors: Raziye
authors: R
authors: Akcilar
authors: Faculty of Medicine, Experimental Animal Research Center, University of Dumlupinar, Kütahya, Turkey.
authors: Aydın
authors: A
authors: Akcilar
authors: Department of Pediatric Surgery, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey.
authors: Bircan
authors: B
authors: Savran
authors: Department of Physiology, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey.
authors: Ceylan
authors: C
authors: Ayada
authors: Department of Pathology, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey.
authors: Cengiz
authors: C
authors: Koçak
authors: Department of Biochemistry, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey.
authors: F Emel
authors: FE
authors: Koçak
authors: Department of Physiology, Faculty of Medicine, University of Dumlupinar, Kütahya, Turkey.
authors: Osman
authors: O
authors: Genç
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D001600:Berberine Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D028281:Chelidonium; D004353:Drug Evaluation, Preclinical; D007410:Intestinal Diseases / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D007422:Intestines / Q000098:blood supply / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010617:Phenanthridines / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001600:Berberine Alkaloids; D010617:Phenanthridines; D010936:Plant Extracts; C060921:ukrain
keywords: Intestine ischemia–reperfusion; OSI; TAS; TOS; Ukrain