title: Clotting activity of polyphosphate-functionalized silica nanoparticles.
abstract: We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.
authors: Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106 (USA). dkudela@chem.ucsb.edu.
authors: Damien
authors: D
authors: Kudela
authors: Stephanie A
authors: SA
authors: Smith
authors: Anna
authors: A
authors: May-Masnou
authors: Gary B
authors: GB
authors: Braun
authors: Alessia
authors: A
authors: Pallaoro
authors: Chi K
authors: CK
authors: Nguyen
authors: Tracy T
authors: TT
authors: Chuong
authors: Sara
authors: S
authors: Nownes
authors: Riley
authors: R
authors: Allen
authors: Nicholas R
authors: NR
authors: Parker
authors: Hooman H
authors: HH
authors: Rashidi
authors: James H
authors: JH
authors: Morrissey
authors: Galen D
authors: GD
authors: Stucky
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D005337:Fibrin / Q000737:chemistry; D006470:Hemorrhage / Q000188:drug therapy; D006487:Hemostasis; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles; D010316:Particle Size; D011122:Polyphosphates / Q000737:chemistry*; D012822:Silicon Dioxide / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic; D013696:Temperature; D013917:Thrombin / Q000737:chemistry; D014914:Whole Blood Coagulation Time; D015040:Zirconium / Q000737:chemistry
chemical_list: D011122:Polyphosphates; D012822:Silicon Dioxide; D005337:Fibrin; D015040:Zirconium; D013917:Thrombin; C028541:zirconium oxide
keywords: hemorrhage; nanoparticles; polyphosphates; silicates; trauma
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