title: Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients.
abstract: Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P < 0.001), waist circumference (β = 0.572, P < 0.001), body fat mass (β = 0.562, P < 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = -0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high-density lipoprotein cholesterol ratio (β = 0.529, P < 0.001), 1/HOMA-IR (β = -0.386, P = 0.006), and spKt/V (β = -0.311, P = 0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P > 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
authors: Nephrology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Gülay
authors: G
authors: Ulusal Okyay
authors: Cardiology Department, Başkent University Faculty of Medicine, Ankara, Turkey.
authors: Kaan
authors: K
authors: Okyay
authors: Radiology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Evşen
authors: E
authors: Polattaş Solak
authors: Cardiology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Asife
authors: A
authors: Sahinarslan
authors: Biochemistry Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Özge
authors: Ö
authors: Paşaoğlu
authors: Nephrology Division, Yüksek Ihtisas Hospital, Kırıkkale, Turkey.
authors: Fatma
authors: F
authors: Ayerden Ebinç
authors: Biochemistry Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Hatice
authors: H
authors: Paşaoğlu
authors: Nephrology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Ülver
authors: Ü
authors: Boztepe Derici
authors: Nephrology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Şükrü
authors: Ş
authors: Sindel
authors: Nephrology Department, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Turgay
authors: T
authors: Arınsoy
mesh_terms: D000273:Adipose Tissue / Q000002:abnormalities* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000002:abnormalities* / Q000503:physiopathology; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors
keywords: Cardiovascular risk; epicardial adipose tissue; hemodialysis