title: Evaluation of eight different clinical staging systems associated with overall survival of chinese patients with hepatocellular carcinoma.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is a common cancer in China, an area of high hepatitis B virus (HBV) infection. Although several staging systems are available, there is no consensus on the best classification to use because multiple factors, such as etiology, clinical treatment and populations could affect the survival of HCC patients.
  
  
  METHODS
  This study analyzed 743 HBV-related Chinese HCC patients who received surgery first and evaluated the predictive values of eight different commonly used staging systems in the clinic.
  
  
  RESULTS
  The overall 1-, 3-, 5-year survival rates and a median survival were 91.5%, 70.3%, 55.3% and 72 months respectively. Barcelona Clinic Liver Cancer (BCLC) staging systems had the best stratification ability and showed the lowest Akaike information criterion (AIC) values (2896.577), followed by tumor-node-metastasis 7 th (TNM 7 th ) (AIC = 2899.980), TNM 6 th (AIC = 2902.17), Japan integrated staging score (AIC = 2918.085), Tokyo (AIC = 2938.822), Cancer of the Liver Italian Program score (AIC = 2941.950), Chinese University Prognostic Index grade (AIC = 2962.027), and Okuda (AIC = 2979.389).
  
  
  CONCLUSIONS
  BCLC staging system is a better staging model for HBV infection patients with HCC in Chinese population among the eight currently used staging systems. These identifications afford a large group of Chinese HCC patients with HBV infection and could be helpful to design a new staging system for a certain population.
authors: Jian-Jun
authors: JJ
authors: Zhao
authors: Tao
authors: T
authors: Yan
authors: Hong
authors: H
authors: Zhao
authors: Jian-Guo
authors: JG
authors: Zhou
authors: Zhen
authors: Z
authors: Huang
authors: Ye-Fan
authors: YF
authors: Zhang
authors: Yuan
authors: Y
authors: Li
authors: Zhi-Yu
authors: ZY
authors: Li
authors: Xin-Yu
authors: XY
authors: Bi
authors: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors: Jian-Qiang
authors: JQ
authors: Cai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology*; D002681:China; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate
references: Eur J Gastroenterol Hepatol. 2004 Jul;16(7):675-80
references: 15201581
references: Hepatology. 2004 Dec;40(6):1396-405
references: 15565571
references: Hepatology. 1995 Oct;22(4 Pt 1):1027-33
references: 7557847
references: J Intern Med. 2004 Mar;255(3):399-408
references: 14871465
references: Semin Liver Dis. 1999;19(3):329-38
references: 10518312
references: J Hepatol. 1999 Jul;31(1):133-41
references: 10424293
references: Dig Liver Dis. 2009 Jun;41(6):431-41
references: 19185555
references: Liver Int. 2012 Aug;32(7):1120-7
references: 22524688
references: J Gastroenterol. 2003;38(3):207-15
references: 12673442
references: Ann Oncol. 2008 Jun;19(6):1117-26
references: 18303031
references: Am J Surg. 2009 Jul;198(1):39-45
references: 19178896
references: Ann Intern Med. 2003 Nov 18;139(10):817-23
references: 14623619
references: Eur J Surg Oncol. 2007 May;33(4):480-7
references: 17129701
references: Hepatology. 2000 Sep;32(3):679-80
references: 10991637
references: Cancer. 2010 Jun 15;116(12):3006-14
references: 20564406
references: Lancet Oncol. 2011 Jul;12(7):654-62
references: 21684210
references: Dig Dis. 2009;27(2):131-41
references: 19546551
references: Cancer. 2004 Aug 1;101(3):642-9
references: 15274079
references: Gut. 2005 Mar;54(3):419-25
references: 15710994
references: Hepatology. 2001 Sep;34(3):529-34
references: 11526539
references: J Gastroenterol Hepatol. 2011 Feb;26(2):340-7
references: 21261725
references: Eur J Cancer. 2006 Oct;42(15):2524-9
references: 16920352
references: Eur J Cancer. 2011 Nov;47(17):2568-75
references: 21835608
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: HPB (Oxford). 2009 Aug;11(5):382-90
references: 19768142
references: Hepatology. 1998 Sep;28(3):751-5
references: 9731568
references: HPB Surg. 2011;2011:818217
references: 21760664
references: Oncologist. 2010;15 Suppl 4:23-33
references: 21115578
references: Cancer. 2002 Mar 15;94(6):1760-9
references: 11920539
references: Cancer. 1985 Aug 15;56(4):918-28
references: 2990661
references: Hepatology. 2005 Nov;42(5):1208-36
references: 16250051
references: J Cancer Res Clin Oncol. 2011 May;137(5):739-50
references: 20607551
references: Hepatology. 2005 Apr;41(4):707-16
references: 15795889