title: Beta-catenin expression in psoriasis.
abstract: BACKGROUND
  Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle morphogenesis has been extensively reported.
  
  
  OBJECTIVE
  is to study β-catenin expression in lesional and non-lesional psoriatic skin to throw light upon its possible role in the pathogenesis of psoriasis.
  
  
  METHODS
  Biopsies were taken from 20 patients with psoriasis vulgaris and from 10 normal controls. The distribution of Beta catenin was investigated using polycolonal rabbits B-catenin antibody-1 by immunohistochemical method.
  
  
  RESULTS
  In this study membranous β-catenin expression was significantly demonstrated in the control group then the non-lesional areas in comparison to the lesional areas (P < 0.001). Nuclear β-catenin staining expression was significantly more demonstrated in lesional and non-lesional areas in comparison to the control cases (P < 0.001).
  
  
  CONCLUSIONS
  The down regulation of membranous β-catenin expression in lesional psoriatic skin might reflect a useful phenotypic marker of hyperprolifration of keratinocytes in psoriasis. Moreover, the mild down regulation of membranous β-catenin expression in non lesional psoriatic skin may provide clues about incipient structural abnormalities in the pathogenesis of psoriasis, providing an early diagnostic indicator for evolution to a generalized form of the disease. Nuclear β-catenin expression was not found in the control group but was demonstrated in lesional and moderately in non-lesional reflecting its role in kerationcyte proliferation.
authors: Department of Dermatology, Andrology and Venoreology, Faculty of Medicine, Menoufia University, Menufia, Egypt.
authors: Mohamed Abd
authors: MA
authors: El-Wahed Gaber
authors: Department of Pathology, Faculty of Medicine, Menoufia University, Menufia, Egypt.
authors: Mona Abd
authors: MA
authors: El-Halim Kandil
authors: Department of Dermatology, Andrology and Venoreology, Faculty of Medicine, Menoufia University, Menufia, Egypt.
authors: Shawki Mahmoud
authors: SM
authors: El-Farargy
authors: Shibin EL-Kom Teaching Hospital, Shibin Al Kawm, Egypt.
authors: Doaa Abd Elmoniem
authors: DA
authors: Galbet
keywords: Beta-catenin; pathogenesis-immunohistochemical; psoriasis
references: J Biol Chem. 2006 Nov 24;281(47):35593-7
references: 17005550
references: Dermatol Online J. 2004 Oct 15;10(2):7
references: 15530297
references: J Invest Dermatol. 2005 Mar;124(3):481-92
references: 15737187
references: Am J Pathol. 2003 Dec;163(6):2277-87
references: 14633602
references: J Dermatol Sci. 2010 Aug;59(2):73-80
references: 20570492
references: Cell Adhes Commun. 1995 Nov;3(4):337-52
references: 8821035
references: Am J Pathol. 2005 Jul;167(1):59-69
references: 15972952
references: Cold Spring Harb Symp Quant Biol. 2008;73:503-12
references: 19022747
references: Cell Res. 2009 Jan;19(1):103-15
references: 19114993
references: Br J Dermatol. 2007 Dec;157(6):1168-77
references: 17916213
references: Mol Cell Biol. 2005 Feb;25(3):969-78
references: 15657425
references: Science. 2004 Mar 5;303(5663):1483-7
references: 15001769
references: J Invest Dermatol. 2002 Jun;118(6):1080-4
references: 12060406
references: Am J Physiol Cell Physiol. 2006 Jul;291(1):C185-8
references: 16436469
references: J Eur Acad Dermatol Venereol. 2004 Nov;18(6):726-7
references: 15482309
references: J R Soc Med. 1996 Jun;89(6):315-9
references: 8758188
references: Nan Fang Yi Ke Da Xue Xue Bao. 2008 Apr;28(4):545-7
references: 18495586
references: J Dermatol. 2004 Apr;31(4):271-6
references: 15187321