title: A rare case report of clear cell variant of oral squamous cell carcinoma.
abstract: Clear cell squamous cell carcinoma (SCC) is an extremely rare heterogenous group of malignant tumour with incompletely understood aetiology. We, hereby present a case of clear cell variant of squamous carcinoma on buccal mucosa in 52-year-old male patient. Histopathology showed sheets of squamous cells with clear cell differentiation and malignant features. Histochemical findings showed negative staining for Periodic Acid-Schiff (PAS), mucicarmine and Oil Red O. Immunohistochemical investigations revealed positive staining for CK 8-18 and negative for S-100. We conclude by emphasizing on the need of careful analysis of all the histopathological and IHC investigations. To predict the exact prognosis of this rare variant more number of case reports are expected to be published in future.
authors: Professor and Head, Department of Oral Pathology, RKDF Dental College , Bhopal, M.P, India .
authors: Purshotam
authors: P
authors: Nainani
authors: Senior Lecturer, Department of Oral Pathology, Dasmesh Institute of Research and Dental Sciences , Faridkot, Punjab, India .
authors: Harkanwal Preet
authors: HP
authors: Singh
authors: Reader, Department of Oral Pathology, RKDF Dental College , Bhopal, M.P, India .
authors: Aparna
authors: A
authors: Paliwal
authors: Senior Lecturer, Department of Oral Pathology, RKDF Dental College , Bhopal, M.P, India .
authors: Neelu
authors: N
authors: Nagpal
keywords: Clear cell carcinoma; Dermatopathology; Hydropic degeneration; Skin; Ulcers
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