title: One-month comparative efficacy of three topical ectoparasiticides against adult brown dog ticks (Rhipicephalus sanguineus sensu lato) on mixed-bred dogs in controlled environment.
abstract: This study was designed to compare the therapeutic and residual efficacy for 1 month of three topical ectoparasiticides on mixed-bred dogs against the brown dog tick, Rhipicephalus sanguineus. Adult dogs (n = 32, 10.8-18.4 kg BW) were allocated to 4 groups (n = 8) and infested with 50 adult ticks on days -8, -2, 7, 14, 21, and 28. Within each group, dogs were treated topically on day 0 with a control solution (CS), Vectra 3D (DPP), Frontline Plus (FM), or K9 Advantix (IP). Ticks were enumerated on dogs 24 h after treatment and each subsequent tick infestation by in situ thumb count assessment without removal and at 48 h by combing and removal. Acaricidal efficacy was calculated using arithmetic means for all 24 and 48 h tick count assessments. From 42 to 56% of the total, infested ticks were found on dogs 48 h post-challenge in the CS group. Therapeutic efficacy for all treatments ranged from 45.5 to 64.6% after 48 h of infestation. Residual efficacy after FM treatment was consistently lower compared to DPP or IP treatments at the 24 h assessments on days 8, 22, 23, and 29. Residual efficacy measured at this last time point was 94.8% for DPP, 83.1% for IP, and 46.9% for FM. This study demonstrates that permethrin-based formulations (DPP and IP) provided a quicker onset of residual protection against brown dog ticks compared to FM. Although DPP and IP are both permethrin-based formulations, DPP exhibited consistently higher residual acaricidal efficacies and was the only treatment that provided >90% protection for 1 month at 24 h post challenge.
authors: Ceva Santé Animale S. A, 10 Avenue de la Ballastière, 33500, Libourne, France, marie.varloud@ceva.com.
authors: Marie
authors: M
authors: Varloud
authors: Josephus J
authors: JJ
authors: Fourie
mesh_terms: D056810:Acaricides / Q000008:administration & dosage*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D004285:Dogs; D005260:Female; D006197:Hair / Q000469:parasitology; D008297:Male; D008726:Methoprene / Q000008:administration & dosage; D026023:Permethrin / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage; D011897:Random Allocation; D048508:Rhipicephalus sanguineus / Q000502:physiology*; D013984:Tick Infestations / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D056810:Acaricides; D011720:Pyrazoles; D026023:Permethrin; D008726:Methoprene; C082360:fipronil
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