title: Clinical vaccine development.
abstract: Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge and the investment of massive funding have enabled the development of vaccines against many infectious diseases as well as other diseases including malignant tumors. The paradigm of clinical vaccine evaluation and licensure has also been modernized based on scientific improvements and historical experience. However, there remain a number of hurdles to overcome. Continuous efforts are focused on increasing the efficacy and reducing the risks related to vaccine use. Cutting-edge knowledge about immunology and microbiology is being rapidly translated to vaccine development. Thus, physicians and others involved in the clinical development of vaccines should have sufficient understanding of the recent developmental trends in vaccination and the diseases of interest.
authors: Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors: Seunghoon
authors: 0000-0002-9976-5120
authors: S
authors: Han
keywords: Clinical trial; History; Vaccination; Vaccines
references: Ann N Y Acad Sci. 2013 May;1285:115-32
references: 23527566
references: Nat Rev Immunol. 2011 Nov 04;11(12 ):865-72
references: 22051890
references: Nat Biotechnol. 2010 Sep;28(9):910-6
references: 20829825
references: Vaccine. 2008 Jun 2;26(23):2890-8
references: 18448211
references: J Public Health Policy. 2006;27(1):38-57; discussion 58-60
references: 16681187
references: J Hum Virol. 2000 Mar-Apr;3(2):63-76
references: 10850891
references: Am J Public Health. 2013 Mar;103(3):e16-29
references: 23327242
references: BioDrugs. 1998 Aug;10(2):137-58
references: 18020591
references: Med Humanit. 2012 Dec;38(2):78-82
references: 22543225
references: Virology. 1991 Nov;185(1):251-7
references: 1656586
references: Emerg Infect Dis. 2006 Jan;12(1):9-14
references: 16494710
references: Pediatr Infect Dis J. 2012 May;31(5):501-8
references: 22327872
references: Vaccine. 2014 Aug 20;32(37):4705-7
references: 24975815
references: Science. 2000 Jan 21;287(5452):443-9
references: 10642539
references: J Exp Med. 1931 Jul 31;54(3):437-47
references: 19869930
references: AAPS J. 2011 Sep;13(3):438-44
references: 21671143
references: Nat Rev Microbiol. 2011 Oct 03;9(12 ):889-93
references: 21963800
references: N Engl J Med. 2010 Apr 22;362(16):1511-20
references: 20410516
references: Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2756-8
references: 21893537
references: JAMA. 2014 Sep 17;312(11):1095-6
references: 25111044