title: Cytoalbuminologic dissociation in Asian patients with Guillain-Barré and Miller Fisher syndromes.
abstract: Cerebrospinal fluid (CSF) protein level, cell count, and its relationship to the timing of lumbar puncture were collected from patients with Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) from various Asian centers. A total of 507 patients with GBS were studied. Overall, 56% had elevated CSF protein level. This was significantly lower than that reported in a recent Dutch study (56% vs 64%). Cytoalbuminologic dissociation was also lower in the Asian cohort (55% vs 64%), with a significantly higher proportion of patients with mild pleocytosis (26% vs 15%). A lower proportion of the 164 patients with MFS had elevated CSF protein level (38% vs 56%), mild pleocytosis (11% vs 26%), and cytoalbuminologic dissociation (41% vs 55%) compared to patients with GBS. In both conditions, cytoalbuminologic dissociation was linked to the timing of lumbar puncture. Cytoalbuminologic dissociation was only observed in half of the Asian patients with GBS and MFS, and it is strongly dependent on the timing of the lumbar puncture.
authors: Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR.
authors: Anna Hiu Yi
authors: AH
authors: Wong
authors: Department of Neurology, National Neuroscience Institute, Singapore.
authors: Thirugnanam
authors: T
authors: Umapathi
authors: Department of Pediatrics, Wakayama National Hospital, Wakayama, Japan.
authors: Yukihiro
authors: Y
authors: Nishimoto
authors: Department of Neurology, Affiliated Hospital of Jining Medical College, Shandong, People's Republic of China.
authors: Yu Zhong
authors: YZ
authors: Wang
authors: Division of Neurology, University Medicine Cluster, National University Hospital, Singapore.
authors: Yee Cheun
authors: YC
authors: Chan
authors: Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors: Nobuhiro
authors: N
authors: Yuki
mesh_terms: D044466:Asian People; D002452:Cell Count; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D011506:Proteins / Q000378:metabolism; D013129:Spinal Puncture; D013997:Time Factors
chemical_list: D011506:Proteins
keywords: Guillain-Barré syndrome; Miller Fisher syndrome; cerebrospinal fluid; lumbar puncture