title: Engineering low-fouling and pH-degradable capsules through the assembly of metal-phenolic networks.
abstract: Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability).
authors: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors: Yi
authors: Y
authors: Ju
authors: Jiwei
authors: J
authors: Cui
authors: Markus
authors: M
authors: Müllner
authors: Tomoya
authors: T
authors: Suma
authors: Ming
authors: M
authors: Hu
authors: Frank
authors: F
authors: Caruso
mesh_terms: D000327:Adsorption; D057219:Biofouling; D001798:Blood Proteins / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*
chemical_list: D001798:Blood Proteins; D056831:Coordination Complexes; D004337:Drug Carriers; D059808:Polyphenols; D011092:Polyethylene Glycols; D007501:Iron