title: Positive reactions to nickel on a patch test do not predict clinical outcome of nickel alloy-based atrial septal defect occluder implantation.
abstract: BACKGROUND
  Patch testing is thought to be necessary prior to metal device implantation to rule out metal allergy-related complications; however, there are controversies over the effects of nickel allergy on the outcome of nickel alloy-based device implantation.
  
  
  OBJECTIVE
  This study aimed to evaluate the adverse events in a Korean population of nickel allergy patients who underwent atrial septal defect (ASD) closure with a nickel-titanium alloy-based device.
  
  
  METHODS
  We retrospectively reviewed the medical records of patients who underwent ASD closure with a nitinol device.
  
  
  RESULTS
  Among 38 patients who had ASD closure, 4 of 5 nickel-allergic patients and 10 of the 33 non-nickel-allergic patients had post-closure complications. All patients fared well, without device failure culminating in device removal.
  
  
  CONCLUSIONS
  In this study, positive reactions to nickel in a patch test were not associated with adverse early or late outcomes following ASD closure with a nickel alloy-based device.
authors: Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Hee Joo
authors: HJ
authors: Kim
authors: Jung U
authors: JU
authors: Shin
authors: Jungsoo
authors: J
authors: Lee
authors: Hemin
authors: H
authors: Lee
authors: Shan
authors: S
authors: Jin
authors: Seo Hyeong
authors: SH
authors: Kim
authors: Ji Yeon
authors: JY
authors: Noh
authors: Kwang Hoon
authors: KH
authors: Lee
mesh_terms: D000328:Adult; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000628:therapy; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology; D009532:Nickel / Q000009:adverse effects*; D010328:Patch Tests; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D055989:Septal Occluder Device / Q000009:adverse effects*; D014025:Titanium / Q000009:adverse effects*; D055815:Young Adult
chemical_list: C040654:titanium nickelide; D009532:Nickel; D014025:Titanium