title: [Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease].
abstract: OBJECTIVE
  To study polymorphisms of catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B) genes among Chinese patients with Parkinson's disease.
  
  
  METHODS
  Genotypes of the COMT and MAO-B genes of 1408 patients with Parkinson's disease was sequenced using Sanger method. And these patients were recruited by Chinese Parkinson Study Group from 29 research centers throughout the country.
  
  
  RESULTS
  The genotypic frequencies of COMT rs4680 AA, AG, GG were 8.9%, 42.0% and 49.1%. Those of rs4818 CC, CG, GG were 42.5%, 45.6% and 11.9%, respectively. The genotype frequencies of MAO-B rs1799836 A/AA, AG, G/GG were 74.4%, 14.1% and 11.5%, respectively. The haplotype formed by COMT rs4680 (GG) and MAO-B rs1799836 (A/AA) genotype has a frequency of 36.86%.
  
  
  CONCLUSIONS
  Polymorphisms of COMT and MAO-B genes has a unique characteristics among Chinese patients with Parkinson's disease. They may be related with differences in drug response in such patients.
authors: Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao Medical College, Yantai, Shandong 264000, P. R. China. Email: yimshao@gmail.com.
authors: Hongying
authors: H
authors: Hao
authors: Ming
authors: M
authors: Shao
authors: Jing
authors: J
authors: An
authors: Chushuang
authors: C
authors: Chen
authors: Xiuli
authors: X
authors: Feng
authors: Shu
authors: S
authors: Xie
authors: Zhuqin
authors: Z
authors: Gu
authors: Biao
authors: B
authors: Chen
mesh_terms: D044466:Asian People / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D008995:Monoamine Oxidase; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase