title: Prescribing style and variation in antibiotic prescriptions for sore throat: cross-sectional study across six countries.
abstract: BACKGROUND
  Variation in prescription of antibiotics in primary care can indicate poor clinical practice that contributes to the increase of resistant strains. General Practitioners (GPs), as a professional group, are expected to have a fairly homogeneous prescribing style. In this paper, we describe variation in prescribing style within and across groups of GPs from six countries.
  
  
  METHODS
  Cross-sectional study with the inclusion of 457 GPs and 6394 sore throat patients. We describe variation in prescribing antibiotics for sore throat patients across six countries and assess whether variation in "prescribing style"--understood as a subjective tendency to prescribe--has an important effect on variation in prescription of antibiotics by using the concept of prescribing style as a latent variable in a multivariable model. We report variation as a Median Odds Ratio (MOR) which is the transformation of the random effect variance onto an odds ratio; Thus, MOR = 1 means similar odds or strict homogeneity between GPs' prescribing style, while a MOR higher than 1 denotes heterogeneity in prescribing style.
  
  
  RESULTS
  In all countries some GPs always prescribed antibiotics to all their patients, while other GPs never did. After adjusting for patient and GP characteristics, prescribing style in the group of GPs from Russia was about three times more heterogeneous than the prescribing style in the group of GPs from Denmark--Median Odds Ratio (6.8, 95% CI 3.1;8.8) and (2.6, 95% CI 2.2;4.4) respectively.
  
  
  CONCLUSIONS
  Prescribing style is an important source of variation in prescription of antibiotics within and across countries, even after adjusting for patient and GP characteristics. Interventions aimed at influencing the prescribing style of GPs must encompass context-specific actions at the policy-making level alongside GP-targeted interventions to enable GPs to react more objectively to the external demands that are in place when making the decision of prescribing antibiotics or not.
authors: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, P. O. Box 2099, DK-1440, Copenhagen, Denmark. gloriac@sund.ku.dk.
authors: Gloria
authors: G
authors: Cordoba
authors: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, P. O. Box 2099, DK-1440, Copenhagen, Denmark. siersma@sund.ku.dk.
authors: Volkert
authors: V
authors: Siersma
authors: Universityof Las Palmas de Gran Canaria, Campus Universitario de Tafira, Las Palmas de GC, CanaryIslands, Spain. bvalcarcel@dmc.ulpgc.es.
authors: Beatriz
authors: B
authors: Lopez-Valcarcel
authors: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, P. O. Box 2099, DK-1440, Copenhagen, Denmark. lbjerrum@sund.ku.dk.
authors: Lars
authors: L
authors: Bjerrum
authors: University Rovira i Virgili, Spanish Society of Family Medicine, Primary Healthcare Centre Jaume I, Tarragona, Spain. carles.llor@urv.cat.
authors: Carl
authors: C
authors: Llor
authors: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, P. O. Box 2099, DK-1440, Copenhagen, Denmark. runa@sund.ku.dk.
authors: Rune
authors: R
authors: Aabenhus
authors: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, ØsterFarimagsgade 5, P. O. Box 2099, DK-1440, Copenhagen, Denmark. marjukka.makela@thl.fi.|Finnish Office for Health Technology Assessment, National Institute for Health and Welfare, Helsinki, Finland. marjukka.makela@thl.fi.
authors: Marjukka
authors: M
authors: Makela
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003657:Decision Making; D005260:Female; D058006:General Practice; D006801:Humans; D008297:Male; D010612:Pharyngitis / Q000188:drug therapy*; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011320:Primary Health Care
chemical_list: D000900:Anti-Bacterial Agents
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