title: Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma.
abstract: Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has a poor prognosis, limited treatment options, and a worldwide incidence that is expected to increase in the next decade. We evaluated Wnt7A expression in 50 surgically resected tumor specimens using quantitative PCR. The expression values, were assessed by clinicopathological factors and K-M and Cox's regression with OS. The mean level of Wnt7A expression had a significant correlation with International Mesothelioma Interest Group (IMIG) stage (P<0.034), gender, smoking history and ethnicity, respectively (P=0.020, P=0.014, P=0.039). In the univariate analysis, low Wnt7A expression was a significant negative factor for overall survival (P=0.043, HR=2.30). However, multivariate Cox's regression revealed no significant factors for overall survival (low Wnt7A: P=0.051, HR=2.283; non-epithelioid subtype: P=0.050, HR=2.898). In patients with epithelioid tumors, those with low Wnt7A expression had significantly worse prognosis (P=0.019, HR=2.98). In patients with epithelioid tumors, females had significantly better prognosis than males (P=0.035). In patients who did not have neoadjuvant chemotherapy, prognosis was significantly more favorable for patients with high Wnt7A expression than for those with low Wnt7A expression (P=0.031). Among the patients with low Wnt7A-expressing tumors, those who received neoadjuvant chemotherapy had better prognosis than those who did not (P=0.024). The results of our study suggest that Wnt7A expression is a putative prognostic factor and a predictor of chemosensitivity.
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Tomomi
authors: T
authors: Hirata
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Qingfeng
authors: Q
authors: Zheng
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Zhao
authors: Z
authors: Chen
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Hiroyasu
authors: H
authors: Kinoshita
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Junichi
authors: J
authors: Okamoto
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Johannes
authors: J
authors: Kratz
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Hui
authors: H
authors: Li
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Natalie
authors: N
authors: Lui
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Hanh
authors: H
authors: Do
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Tiffany
authors: T
authors: Cheng
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Hsin-Hui Katty
authors: HH
authors: Tseng
authors: Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo 113‑8602, Japan.
authors: Kiyoshi
authors: K
authors: Koizumi
authors: Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo 113‑8602, Japan.
authors: Kazuo
authors: K
authors: Shimizu
authors: School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.
authors: Hai-Meng
authors: HM
authors: Zhou
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: David
authors: D
authors: Jablons
authors: Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA.
authors: Biao
authors: B
authors: He
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000235:genetics*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D011379:Prognosis; D051153:Wnt Proteins / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C092778:WNT7A protein, human; D051153:Wnt Proteins
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