title: Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study.
abstract: OBJECTIVE
  Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, limited data exist on the influence of egg consumption on subclinical disease. Thus, we sought to examine whether egg consumption is associated with calcified atherosclerotic plaques in the coronary arteries.
  
  
  METHODS
  In a cross-sectional design, we studied 1848 participants of the NHLBI Family Heart Study without known CHD. Egg consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC.
  
  
  RESULTS
  Mean age was 56.5 years and 41% were male. Median consumption of eggs was 1/week. There was no association between frequency of egg consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.95 (0.66-1.38), 0.94 (0.63-1.40), and 0.90 (0.57-1.42) for egg consumption of almost never, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.66), adjusting for age, sex, BMI, smoking, alcohol, physical activity, income, field center, total calories, and bacon. Additional control for hypertension and diabetes mellitus, or restricting the analysis to subjects with diabetes mellitus or fasting glucose >126 mg/dL did not alter the findings.
  
  
  CONCLUSIONS
  These data do not provide evidence for an association between egg consumption and prevalent CAC in adult men and women.
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Jeremy M
authors: JM
authors: Robbins
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Andrew B
authors: AB
authors: Petrone
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: R Curtis
authors: RC
authors: Ellison
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Steven C
authors: SC
authors: Hunt
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: J Jeffrey
authors: JJ
authors: Carr
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Gerardo
authors: G
authors: Heiss
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Donna K
authors: DK
authors: Arnett
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: J Michael
authors: JM
authors: Gaziano
authors: Division of Internal Medicine (JMR) and Aging (LD, ABP, JMG), Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center (LD, JMG), Boston Veterans Affairs Healthcare System, Boston, MA; Section of Preventive Medicine & Epidemiology (RCE), Boston University, Boston, MA; Department of Cardiovascular Genetics, University of Utah, Salt Lake City (SCH); Department of Radiology (JJC), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Epidemiology (GH), School of Public Health, the University of North Carolina at Chapel Hill, NC; Division of Epidemiology (DKA), University of Minnesota, Minneapolis.
authors: Luc
authors: L
authors: Djoussé
keywords: atherosclerosis; coronary calcium; diet; egg; epidemiology; subclinical disease
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