title: Turn up the heat: circulating serotonin tunes our internal heating system.
abstract: Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
authors: Luxembourg Centre for Systems Biomedicine (LCSB), Campus Belval, 7 Avenue des Hauts Fourneaux, L-4362 Esch, Luxembourg, Luxembourg; Department of Internal Medicine II, Saarland University Medical Center at Homburg/Saar, Kirrberger Straße 100, D-66424 Homburg, Germany. Electronic address: jg.schneider@outlook.com.
authors: Jochen G
authors: JG
authors: Schneider
authors: Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA. Electronic address: jnadeau@pnri.org.
authors: Joseph H
authors: JH
authors: Nadeau
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D007333:Insulin Resistance / Q000235:genetics*; D007473:Ion Channels / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D012701:Serotonin / Q000096:biosynthesis*; D022722:Thermogenesis / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D012701:Serotonin; D014365:Tryptophan Hydroxylase