title: A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis.
abstract: A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%. Graphical AbstractStarting from 3-nitropropanyl chloride, Fingolimod was obtained in 4 steps with an overall yield of 31%.
authors: School of Pharmacy, Yantai University, Yantai, Shandong 264005 China.
authors: Ning
authors: N
authors: Yan
authors: School of Pharmacy, Yantai University, Yantai, Shandong 264005 China.
authors: Kai
authors: K
authors: Chen
authors: School of Pharmacy, Yantai University, Yantai, Shandong 264005 China.
authors: Xinfa
authors: X
authors: Bai
authors: School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, Anhui 243002 China.
authors: Lei
authors: L
authors: Bi
authors: School of Pharmacy, Yantai University, Yantai, Shandong 264005 China.
authors: Lei
authors: L
authors: Yao
keywords: 3-nitropropionic acid; Fingolimod; Immunosuppressant
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