title: The potential mechanism of bursal-derived BP8 on B cell developments.
abstract: The bursa of Fabricius, the key humoral immune organ unique to birds, is critical for B cell differentiation and antibody production. BP8 (AGHTKKAP) is a novel immunomodulatory peptide that regulates B-cell development. Gene microarray was used to investigate the mechanism of BP8 on B cell development. BP8 regulated expressions of 1,570 genes that were involved in retinol metabolism, the Wnt signaling pathway, MAPK pathway, Jak-Stat pathway, Notch signaling pathway, cytokine-cytokine receptor interaction, and Ca(2+) signals. Finally, BP8 triggered ADH7 and RDH10 expression, interacted with retinol binding protein, and regulated retinol uptake in vitro and vivo. These data reveal a bursal-derived multifunctional factor, BP8, as a novel biomaterial which is essential for the development of the immune system and represents an important linker between the B cell development and retinol metabolism. This study elucidates the mechanisms involved in humoral immune system and has implications in treating human diseases.
authors: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China.
authors: Xiao-Dong
authors: XD
authors: Liu
authors: Fu-Bo
authors: FB
authors: Zhang
authors: Hu
authors: H
authors: Shan
authors: Pu-Yan
authors: PY
authors: Chen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000502:physiology*; D001717:Birds; D002061:Bursa, Synovial; D002454:Cell Differentiation / Q000187:drug effects*; D020869:Gene Expression Profiling; D007155:Immunologic Factors / Q000302:isolation & purification / Q000378:metabolism*; D046228:Microarray Analysis; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D014801:Vitamin A / Q000378:metabolism
chemical_list: D007155:Immunologic Factors; D010455:Peptides; D014801:Vitamin A