title: Evidence that the genetic polymorphism rs1412115 on chromosome 10 is associated with risk for oral squamous cell carcinoma.
abstract: A genome-wide association study on schizophrenia in Jewish population discovered a novel single nucleotide polymorphism (SNP), rs1412115, on chromosome 10. It has been proved that neuropilin-1 (NRP-1) gene located on chromosome 10, tightly close to rs1412115, is associated with increased risk for oral squamous cell carcinoma (OSCC). In the present study, we hypothesized that SNP rs1412115:A>G is associated with increased risk for OSCC. We therefore genotyped this polymorphism in 295 patients with OSCC and 594 cancer-free controls in the Chinese Han population, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectroscopy. The pooled odds ratio was 1.42 (95% confidence interval [CI]=1.01-1.99, p=0.042) for carriers with the A version of the allele (AA and AG) compared with GG, and 1.46 (95% CI=1.02-2.09, p=0.036) for AG compared with GG. Our data provide evidence that the rs1412115: A>G polymorphism increases the risk of OSCC in Chinese Han populations. Larger population-based studies are needed to confirm these results.
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: malu_0206@aliyun.com.
authors: Lu
authors: L
authors: Ma
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: puredust1025@hotmail.com.
authors: Jie
authors: J
authors: Chen
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: xiaomengsongdoc@126.com.
authors: Xiaomeng
authors: X
authors: Song
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: yuanhua1973@126.com.
authors: Hua
authors: H
authors: Yuan
authors: Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: yuqunwang@yeah.com.
authors: Yuqun
authors: Y
authors: Wang
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: wynoms@gmail.com.
authors: Yunong
authors: Y
authors: Wu
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: wzl710@163.com.
authors: Zilu
authors: Z
authors: Wang
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
keywords: Genome-wide association study; Oral squamous cell carcinoma; Single nucleotide polymorphism