title: Spontaneous Intestinal Perforation and Necrotizing Enterocolitis: A 16-Year Retrospective Study from a Single Center.
abstract: BACKGROUND
  Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are serious abdominal conditions that affect preterm infants but are poorly understood. This single-center retrospective study was performed to identify the factors associated with NEC and SIP.
  
  
  METHODS
  This study involved 3,464 preterm infants recruited over 16 years. A total of 136 NEC and 24 SIP were analyzed and adjusted odds ratios (aOR) were determined by logistic regression.
  
  
  RESULTS
  Compared with the controls, NEC was associated with a Z-score for birth weight lower than -1 (aOR = 2.1 [1.1-3.9], p = 0.02) and lower than -2 (aOR = 4.4 [1.8-10.4], p < 0.01). NEC was associated with gestational ages of less than 31 weeks and with breech presentations (aOR = 1.5 [1.0-2.3], p = 0.03). In contrast, compared with the controls, SIP was associated with gestational ages of less than 26 weeks (aOR = 17.4 [3.1-96.2], p < 0.001) and multiple pregnancy (aOR = 2.9 [1.2-6.9], p = 0.02). Rates of mortality and cerebral lesions were higher in patients with NEC (25.0 and 13.2%, respectively) than with the controls (10.1 and 6.9%, respectively) and similar between patients with SIP (12.5 and 8.3%, respectively) and the controls. CONCLUSIon: NEC and SIP differed in risk factors and prognosis. Early distinction of SIP from NEC could impact on surgical decision.
authors: Department of Chirurgie Pédiatrique, CHU Nantes, Nantes, France.
authors: Etienne
authors: E
authors: Suply
authors: Department of Chirurgie Pédiatrique, CHU Nantes, Nantes, France.
authors: Marc-David
authors: MD
authors: Leclair
authors: Institut des Maladies de l'Appareil Digestif DHU 2020, INSERM U913, Nantes, France.
authors: Michel
authors: M
authors: Neunlist
authors: Department of Neonatology, CHU Nantes, Nantes, France.
authors: Jean-Christophe
authors: JC
authors: Roze
authors: Department of Neonatology, CHU Nantes, Nantes, France.
authors: Cyril
authors: C
authors: Flamant
mesh_terms: D020345:Enterocolitis, Necrotizing / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D007416:Intestinal Perforation / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors