title: Effects of local simvastatin on periosteal distraction osteogenesis in rabbits.
abstract: Our aim was to evaluate the effect of local simvastatin on the formation of new bone using a new design of periosteal distractor. The distractors were placed between the periosteum and bone at the inferior border of the mandible of 20 New Zealand rabbits. In the first group (n=10) simvastatin was applied locally to the distraction zone. The other 10 rabbits served as controls. The formation of new bone was evaluated with digital direct radiography, computed tomography (CT), and histomorphometric analyses. New bone formed in all rabbits, but more formed in the experimental group according to histomorphometric variables. However, other measurements did not differ significantly between the groups. The new design of the periosteal distraction device was successful in causing new bone to form. Local simvastatin made no significant contribution to the procedure.
authors: Private Practice, Adana, Turkey.
authors: O E
authors: OE
authors: Kahraman
authors: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, Adana, Turkey; Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Rangsit University, Pathum Thani, Thailand. Electronic address: ozgerdogan@yahoo.com.
authors: Ö
authors: Ö
authors: Erdogan
authors: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, 01330 Balcali, Adana, Turkey.
authors: H
authors: H
authors: Namli
authors: Department of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors: L
authors: L
authors: Sencar
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D015519:Bone Density / Q000187:drug effects; D001860:Bone Plates; D004867:Equipment Design; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008334:Mandible / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D010521:Periosteum / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D011817:Rabbits; D011856:Radiographic Image Enhancement / Q000379:methods; D019821:Simvastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D013526:Surgical Mesh; D015503:Surgical Sponges; D014025:Titanium / Q000737:chemistry; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D014025:Titanium
keywords: Bone augmentation; Osteogenesis; Periosteal distraction; Simvastatin