title: The assessment of the relationship between personality, the presence of the 5HTT and MAO-A polymorphisms, and the severity of climacteric and depressive symptoms in postmenopausal women.
abstract: The purpose of this study is to determine the relationship between personality, the serotonin transporter (5HTT) and monoamine oxidase A (MAO-A) polymorphisms and the severity of climacteric and depressive symptoms in postmenopausal women. The study involved 272 healthy postmenopausal women from Poland. This survey-based study was performed using the following: the Beck Depression Inventory for depressive symptoms, the Blatt-Kupperman Menopausal Index and the Neuroticism-Extroversion-Openness-Five Factor Inventory for personality. A polymerase chain reaction was employed to identify the DNA polymorphisms. The women were aged 55.4 ± 5.5 years on average. Significant correlations were proved between the allele frequency of the 30-bp variable-number tandem repeat (VNTR) polymorphism in the MAO-A promoter region and the incidence of depressive symptoms in the women analysed (p ≤ 0.05), as well as between the severity of climacteric symptoms in the postmenopausal women and the allele frequency of the polymorphism in the 5HTT gene (the 5HTT 's' variant) (p ≤ 0.05). There was a significant correlation between the severity of climacteric and depressive symptoms (p < 0.001). (1) The severity of climacteric and depressive symptoms depends on personality traits. (2) Personality traits are biologically determined, and the level of their expression is associated with the 5HTT polymorphism. (3) Identification of homogeneous groups of women having predispositions to depressive and severe climacteric symptoms may help to implement early prevention programmes for this group of recipients.
authors: Department of Nursing, Pomeranian Medical University of Szczecin, 48 Żołnierska St., 71-210, Szczecin, Poland.
authors: Anna
authors: A
authors: Jurczak
authors: Małgorzata
authors: M
authors: Szkup
authors: Sylwia
authors: S
authors: Wieder-Huszla
authors: Anna
authors: A
authors: Grzywacz
authors: Agnieszka
authors: A
authors: Samochowiec
authors: Beata
authors: B
authors: Karakiewicz
authors: Jerzy
authors: J
authors: Samochowiec
authors: Elżbieta
authors: E
authors: Grochans
mesh_terms: D000368:Aged; D002979:Climacteric / Q000235:genetics* / Q000523:psychology; D003863:Depression / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010551:Personality / Q000235:genetics; D010555:Personality Inventory; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D017698:Postmenopause / Q000235:genetics* / Q000523:psychology; D011401:Promoter Regions, Genetic; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012720:Severity of Illness Index; D012959:Socioeconomic Factors
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
references: Compr Psychiatry. 2004 Jul-Aug;45(4):246-53
references: 15224266
references: Brain Behav. 2012 Nov;2(6):806-13
references: 23170243
references: Science. 2003 Jul 18;301(5631):386-9
references: 12869766
references: J Med Assoc Thai. 2002 Jun;85 Suppl 1:S1-15
references: 12188398
references: J Gerontol. 1976 Sep;31(5):564-70
references: 950450
references: J Affect Disord. 1995 Dec 13;35(3):139-43
references: 8749842
references: JAMA. 1999 Nov 10;282(18):1737-44
references: 10568646
references: Endocr Rev. 2009 Aug;30(5):465-93
references: 19589949
references: PLoS One. 2013;8(9):e75926
references: 24098745
references: Psychiatr Pol. 2000 Jan-Feb;34(1):99-109
references: 10853361
references: Psychophysiology. 2009 Mar;46(2):285-92
references: 19170952
references: Hum Reprod Update. 2007 Nov-Dec;13(6):559-65
references: 17630397
references: Am J Med Genet. 1998 May 8;81(3):257-67
references: 9603615
references: Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):90-6
references: 12815746
references: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):1062-73
references: 15951088
references: Psychopharmacology (Berl). 2002 Dec;164(4):385-91
references: 12457268
references: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):713-7
references: 15908092
references: Menopause. 2007 May-Jun;14(3 Pt 2):572-9
references: 17476147
references: Am J Psychiatry. 2006 May;163(5):857-64
references: 16648327
references: Psychiatry Res. 2000 Jul 24;95(1):9-23
references: 10904119
references: Am J Med Genet. 1997 Feb 21;74(1):65-72
references: 9034010
references: Depress Anxiety. 2006;23(5):281-9
references: 16688731
references: World Health Organ Tech Rep Ser. 1996;866:1-107
references: 8942292
references: Nucleic Acids Res. 1988 Feb 11;16(3):1215
references: 3344216
references: Psychiatry Res. 2005 Feb 28;133(2-3):229-37
references: 15740998
references: Psychopharmacology (Berl). 2002 Aug;163(1):42-53
references: 12185399
references: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1263-8
references: 18495314
references: Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):900-6
references: 19152387
references: Mol Cell Endocrinol. 2002 May 31;191(1):27-33
references: 12044916
references: Biol Psychiatry. 2005 Jun 15;57(12):1485-92
references: 15953484
references: J Pers Soc Psychol. 1987 Jan;52(1):81-90
references: 3820081
references: Depress Anxiety. 2004;20(2):92-7
references: 15390211
references: Mol Psychiatry. 1999 Jul;4(4):385-8
references: 10483057
references: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:125-30
references: 23707423
references: Arch Gen Psychiatry. 1961 Jun;4:561-71
references: 13688369
references: Psychopharmacology (Berl). 2007 Nov;194(4):545-54
references: 17628790
references: Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):85-9
references: 15108187
references: Arch Gen Psychiatry. 2006 Oct;63(10):1113-20
references: 17015813
references: Arch Gen Psychiatry. 1993 Nov;50(11):853-62
references: 8215811
references: Nucleic Acids Res. 1991 Feb 11;19(3):689
references: 2011543
references: Brain Behav. 2011 Nov;1(2):109-18
references: 22399090
references: Psychol Bull. 2004 Nov;130(6):887-919
references: 15535742
references: Mol Psychiatry. 2004 Feb;9(2):197-202
references: 14966478
references: Menopause. 2008 Sep-Oct;15(5):841-7
references: 18521049
references: Psychopharmacology (Berl). 1999 Oct;146(4):473-81
references: 10550498
references: Maturitas. 1998 Oct 12;30(2):113-8
references: 9871905
references: J Clin Endocrinol Metab. 1953 Jun;13(6):688-703
references: 13061588
references: Neuropsychobiology. 2001;43(4):248-53
references: 11340364
references: Arch Womens Ment Health. 2014 Aug;17(4):279-89
references: 24957780
references: Hum Genet. 1998 Sep;103(3):273-9
references: 9799080
references: Br J Psychiatry. 2002 Aug;181:118-22
references: 12151281
references: Hum Genet. 1999 Dec;105(6):542-51
references: 10647887
references: J Pers Soc Psychol. 1985 Sep;49(3):710-21
references: 4045699
references: Science. 1996 Nov 29;274(5292):1527-31
references: 8929413