title: [Treatment with recombinant thrombomodulin on disseminated intravascular coagulation caused by urinary tract infections; a retrospective comparative study with control cases].
abstract: We examined the efficacy of recombinant thrombomodulin (rTM) for treatment of patients with disseminated intravascular coagulation (DIC) caused by urinary tract infections. Thirteen DIC patients treated with rTM (rTM group) and 11 not receiving rTM (non-rTM group) were enrolled in this study. Blood data including coagulation markers collected before and after the treatment,a hospitalized term,and period of antibiotic treatment were compared. There were no significant differences in baseline characteristics between the two groups. Both groups showed significant improvement in all parameters such as blood biochemical data,coagulation markers,and DIC score 5-7 days after treatment. However, changes in platelet and DIC score from baseline to early phase (day 1-3) were significantly greater in the rTM group than in the non-rTM group (p＜0.05). In addition,changes in FDP value showed slight but not significant improvement in rTM group compared to the non-rTM group in the early treatment phase (p＝ 0.084). The period of antibiotic usage was significantly shorter in the rTM group,whereas the hospitalized term showed no significant difference between the groups. Definite adverse effects were not present in the rTM group. In conclusion,administration of rTM may have a beneficial effect in patients with DIC induced by urinary tract infections,compared with conventional treatment.
authors: The Department of Urology, Ishikawa Prefectural Central Hospital; The Department of Integrative Therapy and Urology, Kanazawa University Graduate School of Medical Science.
authors: Kazuaki
authors: K
authors: Machioka
authors: The Department of Urology, Ishikawa Prefectural Central Hospital.
authors: Kazuyoshi
authors: K
authors: Shigehara
authors: The Department of Urology, Ishikawa Prefectural Central Hospital.
authors: Suguru
authors: S
authors: Kadomoto
authors: The Department of Urology, Ishikawa Prefectural Central Hospital.
authors: Hiroaki
authors: H
authors: Iwamoto
authors: The Department of Urology, Ishikawa Prefectural Central Hospital.
authors: Tohru
authors: T
authors: Miyagi
authors: The Department of Urology, Ishikawa Prefectural Central Hospital.
authors: Takao
authors: T
authors: Nakashima
authors: The Department of Integrative Therapy and Urology, Kanazawa University Graduate School of Medical Science.
authors: Mikio
authors: M
authors: Namiki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage; D001550:Benzamidines; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006146:Guanidines / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D018180:Thrombomodulin / Q000008:administration & dosage*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000150:complications*
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D006146:Guanidines; D011994:Recombinant Proteins; D018180:Thrombomodulin; D006493:Heparin; C032855:nafamostat