title: Exploring gut microbes in human health and disease: Pushing the envelope.
abstract: Humans have coevolved with their microbes over thousands of years, but this relationship, is now being dramatically affected by shifts in the collective human microbiome resulting from changes in the environment and societal norms. Resulting perturbations of intestinal host-microbe interactions can lead to miscues and altered host responses that increase the risk of pathogenic processes and promote "western" disorders such as inflammatory bowel diseases, cancers, obesity, diabetes, autism, and asthma. Given the current challenges and limitations in gene therapy, approaches that can reshape the gut microbiome represent a reasonable strategy for restoring the balance between host and microbes. In this review and commentary, we highlight recent progress in our understanding of the intestinal microbiome in the context of health and diseases, focusing on mechanistic concepts that underlie the complex relationships between host and microbes. Despite these gains, many challenges lie ahead that make it difficult to close the gap between the basic sciences and clinical application. We will discuss the potential therapeutic strategies that can be used to manipulate the gut microbiota, recognizing that the promise of pharmabiotics ("bugs to drugs") is unlikely to be completely fulfilled without a greater understanding of enteric microbiota and its impact on mammalian physiology. By leveraging the knowledge gained through these studies, we will be prepared to enter the era of personalized medicine where clinical inventions can be custom-tailored to individual patients to achieve better outcomes.
authors: Department of Biochemistry, Rush University Medical Center, Cohn Research Building, 1735 W. Harrison St., Room 506, Chicago, IL 60612, United States.
authors: Jun
authors: J
authors: Sun
authors: Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL 60637, United States.
authors: Eugene B
authors: EB
authors: Chang
keywords: Cancer; Dysbiosis; Gut–brain axis; Inflammation; Obesity; SCFA; Secondary bile acid; Vitamin D receptor
references: Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9768-73
references: 24965364
references: Science. 2013 Feb 1;339(6119):548-54
references: 23363771
references: Am J Gastroenterol. 2012 Oct;107(10):1452-9
references: 23034604
references: Brain Behav Immun. 2011 Mar;25(3):397-407
references: 21040780
references: Gut. 1987 Oct;28(10 ):1221-7
references: 3678950
references: Gut Microbes. 2011 Jul-Aug;2(4):211-6
references: 21983063
references: Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1307-13
references: 24675659
references: PLoS One. 2011;6(10):e25792
references: 22043294
references: Gastroenterology. 2014 May;146(6):1573-82
references: 24412527
references: J Cell Biochem. 2005 Apr 1;94(5):917-43
references: 15578590
references: Gut. 2014 Aug;63(8):1275-83
references: 24021287
references: Nature. 2012 Jun 13;486(7402):207-14
references: 22699609
references: Microbiome. 2013 Mar 04;1(1):9
references: 24451366
references: ISME J. 2011 Jan;5(1):82-91
references: 20613793
references: FEMS Microbiol Ecol. 2014 Feb;87(2):357-67
references: 24117923
references: Nature. 2007 Oct 18;449(7164):804-10
references: 17943116
references: Nat Commun. 2013;4:2163
references: 23860099
references: Infect Agent Cancer. 2013 Nov 04;8(1):42
references: 24180596
references: J Lipid Res. 2010 Apr;51(4):771-84
references: 19783811
references: Science. 2010 Nov 26;330(6008):1168-9
references: 21109643
references: Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4601-8
references: 18216259
references: Gut. 2015 Jul;64(7):1082-94
references: 25080448
references: Science. 2002 May 17;296(5571):1313-6
references: 12016314
references: ISME J. 2013 Apr;7(4):880-4
references: 23235292
references: Annu Rev Nutr. 2011 Aug 21;31:15-31
references: 21568707
references: Nature. 2014 Jan 23;505(7484):559-63
references: 24336217
references: Gut Microbes. 2013 Jan-Feb;4(1):17-27
references: 23202796
references: J Physiol. 2014 Jul 15;592(14):2989-97
references: 24756641
references: J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):37-40
references: 18515093
references: FEMS Microbiol Ecol. 2011 Jul;77(1):107-19
references: 21395623
references: Nat Med. 2013 May;19(5):576-85
references: 23563705
references: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4523-30
references: 20837534
references: Gut. 2013 Dec;62(12):1673
references: 23461897
references: Diabetes. 2007 Jul;56(7):1761-72
references: 17456850