title: Anti-diabetic molecules from Cycas pectinata Griff. traditionally used by the Maiba-Maibi.
abstract: Bioactivity guided chemical investigation on active anti-diabetic constituents of the fruits of Cycas pectinata Griff. (FCP) characterized EAFr-5 as the most potent sub fraction which significantly reduced the blood glucose level to normal in STZ induced diabetic rats. It was shown to contain the biflavonoids amentoflavone (1) and 2,3-dihydroamentoflavone (2) which exhibited significantly high inhibitory potency against α-glucosidase (IC50 8.09 ± 0.023 and 9.77 ± 0.032 μM, respectively) and α-amylase (IC50 73.6 ± 0.48 and 39.69 ± 0.39 μM, respectively). This is the first report of bioactivity guided isolation of anti-diabetic constituents from the traditionally used fruits of Cycas pectinata Griff.
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: S
authors: S
authors: Laishram
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: Y
authors: Y
authors: Sheikh
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: D S
authors: DS
authors: Moirangthem
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: L
authors: L
authors: Deb
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: B C
authors: BC
authors: Pal
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors: N C
authors: NC
authors: Talukdar
authors: Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India. Electronic address: jcborah03@yahoo.com.
authors: J C
authors: JC
authors: Borah
mesh_terms: D000818:Animals; D044946:Biflavonoids / Q000378:metabolism / Q000494:pharmacology*; D029784:Cycas / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005638:Fruit / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017208:Rats, Wistar; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: C553351:2,3-dihydroamentoflavone; D044946:Biflavonoids; D007004:Hypoglycemic Agents; C011164:amentoflavone; D000516:alpha-Amylases; D000520:alpha-Glucosidases
keywords: Cycas pectinata; Diabetes; Maiba-Maibi; α-Amylase; α-Glucosidase