title: Diagnosis and treatment of depression and cognitive impairment in late life.
abstract: Cognitive impairment in late-life depression is prevalent, disabling, and heterogeneous. Although mild cognitive impairment in depression does not usually progress to dementia, accurate assessment of cognition is vital to prognosis and treatment planning. For example, executive dysfunction often accompanies late-life depression, influences performance across cognitive domains, and is associated with poor antidepressant treatment outcomes. Here, we review how assessment can capture dysfunction across cognitive domains and discuss cognitive trajectories frequently observed in late-life depression in the context of the neurobiology of this disorder. We also review the efficacy of a sample of interventions tailored to specific cognitive profiles.
authors: Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, New York.
authors: Sarah Shizuko
authors: SS
authors: Morimoto
authors: Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, New York.
authors: Dora
authors: http://orcid.org/0000-0002-2676-2957
authors: D
authors: Kanellopoulos
authors: Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut.
authors: Kevin J
authors: KJ
authors: Manning
authors: Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, New York.
authors: George S
authors: GS
authors: Alexopoulos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology / Q000628:therapy; D000928:Antidepressive Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D003704:Dementia / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D011613:Psychotherapy / Q000379:methods
chemical_list: D000928:Antidepressive Agents
keywords: antidepressants; cognitive control; cognitive impairment; geriatric depression; older adults; psychotherapy
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