title: Preparation of spherical macroporous poly(lactic-co-glycolic acid) for bone tissue regeneration.
abstract: Spherical macroporous poly(lactic-co-glycolic acid) (PLGA) has been synthesised using an emulsion method. Polyvinyl alcohol and Pluronic F127 have been used as dispersing and porogen agent, respectively. The diameter of the spherical PLGA is about 20 μm and the pore size of the PLGA macroporous is about 2-2.5 μm observed by scanning electron microscopy. After immersing in simulated body fluid, the PLGA materials can induce the formation of hydroxyapatite (HAP) on their surface. The HAP-PLGA has been obtained and used as the host for drug release. Furthermore, the drug-loaded samples possess the various drug release performance by adjusting the thickness of the HAP layer. This highly satisfied composite material is expected to be promising in the applications in tissue regeneration engineering.
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
authors: Chunhui
authors: C
authors: Bian
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
authors: Huiming
authors: H
authors: Lin
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
authors: Xiaofeng
authors: X
authors: Li
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
authors: Jie
authors: J
authors: Ma
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China.
authors: Pingping
authors: P
authors: Jiang
authors: Department of Photoelectric Band Gap Materials Key Laboratory of Ministry of Education, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, People's Republic of China. qufengyu2013@gmail.com.
authors: Fengyu
authors: F
authors: Qu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D008954:Models, Biological; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite