title: Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy.
abstract: We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein Bcl-2 was significantly increased. Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria. This mechanism underlies the observed reduction in Bax expression and upregulation of Bcl-2 expression.
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Shaonian
authors: S
authors: Xu
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Jiachuan
authors: J
authors: Liu
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Yongming
authors: Y
authors: Zhang
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Chunlin
authors: C
authors: Wang
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Jinbiao
authors: J
authors: Wang
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Yanyan
authors: Y
authors: Yang
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Jian
authors: J
authors: Huo
authors: Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
authors: Wenjiang
authors: W
authors: Sun
keywords: Bax; Bcl-2; caspase-3; craniocerebral injury; cytochrome c; hyperbaric oxygen; neural regeneration
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