title: Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease.
abstract: A sputum eosinophilia is observed in 10-40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.
authors: Institute for Lung Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK; Department of Medicine, Faculty of Medicine, Benghazi University, Benghazi, Libya.
authors: Osama
authors: O
authors: Eltboli
authors: Vijay
authors: V
authors: Mistry
authors: Bethan
authors: B
authors: Barker
authors: Chris E
authors: CE
authors: Brightling
mesh_terms: D000328:Adult; D001485:Basement Membrane / Q000473:pathology*; D015415:Biomarkers / Q000097:blood*; D004802:Eosinophilia; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers
keywords: blood eosinophil; chronic obstructive pulmonary disease; remodelling; reticular basement membrane; submucosal eosinophil
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