title: Multifunctional self-assembled polymeric nanoprobes for FRET-based ratiometric detection of mitochondrial H2O2 in living cells.
abstract: A ratiometric, multifunctional nanoprobe was prepared consisting of a self-assembled polymeric micelle as the carrier, tetraphenylethene (TPE) as the donor, fluorescent boronate as the H2O2-responsive acceptor, and triphenylphosphonium as a mitochondria-targeted moiety. The assembled nanoparticles could detect both exogenous and endogenous mitochondrial H2O2 changes in living cells.
authors: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. niu@mail.ipc.ac.cn.
authors: Jing
authors: J
authors: Qiao
authors: Zhi
authors: Z
authors: Liu
authors: Ye
authors: Y
authors: Tian
authors: Man
authors: M
authors: Wu
authors: Zhongwei
authors: Z
authors: Niu
mesh_terms: D000818:Animals; D001897:Boronic Acids / Q000737:chemistry; D002460:Cell Line; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D051379:Mice; D008928:Mitochondria / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D011108:Polymers; D006861:Hydrogen Peroxide