title: MicroRNAs and benign biliary tract diseases.
abstract: Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5%), but they are responsible for the secretion of up to 40% of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.
authors: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors: Sergio A
authors: SA
authors: Gradilone
authors: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors: Steven P
authors: SP
authors: O'Hara
authors: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors: Tetyana V
authors: TV
authors: Masyuk
authors: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors: Maria Jose Lorenzo
authors: MJ
authors: Pisarello
authors: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors: Nicholas F
authors: NF
authors: LaRusso
mesh_terms: D001650:Bile Duct Neoplasms / Q000235:genetics / Q000378:metabolism; D001653:Bile Ducts, Intrahepatic; D001656:Biliary Atresia / Q000235:genetics / Q000378:metabolism; D001659:Biliary Tract / Q000166:cytology; D001660:Biliary Tract Diseases / Q000235:genetics* / Q000378:metabolism; D018281:Cholangiocarcinoma / Q000235:genetics / Q000378:metabolism; D015209:Cholangitis, Sclerosing / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs
references: Gastroenterology. 2011 Jun;140(7):1855-9, 1859.e1
references: 21515270
references: J Hepatol. 2009 Feb;50(2):358-69
references: 19070389
references: Scand J Gastroenterol. 2002 Oct;37(10):1205-11
references: 12408527
references: Aliment Pharmacol Ther. 2011 Oct;34(7):702-13
references: 21790682
references: J Immunol. 2005 Dec 1;175(11):7447-56
references: 16301652
references: Biochim Biophys Acta. 2011 Oct;1812(10):1202-12
references: 21392578
references: J Clin Invest. 2008 Nov;118(11):3714-24
references: 18949056
references: J Pathol. 2010 Nov;222(3):238-48
references: 20814903
references: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
references: 16885212
references: Mayo Clin Proc. 1998 Jan;73(1):80-9
references: 9443684
references: Tumour Biol. 2013 Jun;34(3):1579-88
references: 23417858
references: Br J Cancer. 2013 Dec 10;109(12):3092-104
references: 24169343
references: J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):186-92
references: 22167021
references: Dig Dis Sci. 2011 Jun;56(6):1693-701
references: 21086164
references: J Hepatol. 2002 Mar;36(3):321-7
references: 11867174
references: J Control Release. 2013 Dec 28;172(3):962-74
references: 24075926
references: Curr Opin Gastroenterol. 2009 May;25(3):265-71
references: 19349863
references: Int J Hepatol. 2012;2012:793569
references: 21994888
references: Hepatology. 2009 May;49(5):1595-601
references: 19296468
references: Nucleic Acids Res. 2007;35(9):2885-92
references: 17439965
references: Hepatology. 2014 Sep;60(3):896-907
references: 24497320
references: Am J Med Genet C Semin Med Genet. 2009 Nov 15;151C(4):296-306
references: 19876928
references: Lancet. 2009 Nov 14;374(9702):1704-13
references: 19914515
references: Hepatology. 2007 Aug;46(2):566-81
references: 17661405
references: Asian Pac J Cancer Prev. 2013;14(2):829-34
references: 23621247
references: Gastroenterology. 2012 Jul;143(1):246-56.e8
references: 22484120
references: Hepatology. 1989 Oct;10(4):430-6
references: 2777204
references: PLoS One. 2013;8(7):e69496
references: 23922722
references: FEBS Lett. 2012 Sep 21;586(19):3271-8
references: 22819820
references: Cell Cycle. 2009 May 1;8(9):1324-8
references: 19342876
references: Gastroenterology. 2009 Mar;136(3):1081-90
references: 19185580
references: J Nippon Med Sch. 2009 Aug;76(4):188-97
references: 19755794
references: PLoS One. 2011;6(8):e23584
references: 21858175
references: Am J Physiol Renal Physiol. 2011 Mar;300(3):F602-10
references: 21228106
references: J Pathol. 2009 Nov;219(3):365-72
references: 19718708
references: Oncogene. 2008 Jan 10;27(3):378-86
references: 17621267
references: Semin Immunopathol. 2009 Sep;31(3):383-97
references: 19468733
references: Ann Hepatol. 2012 Nov-Dec;11(6):819-26
references: 23109444
references: Nucleic Acids Res. 2010 Jun;38(10):3222-32
references: 20144951
references: Int J Biochem Cell Biol. 2011 Feb;43(2):245-56
references: 19735739
references: Lancet. 2014 Jun 21;383(9935):2168-79
references: 24581682
references: Hepatology. 2012 Feb;55(2):465-75
references: 21953056
references: Gastroenterology. 2014 Jun;146(7):1795-808.e12
references: 24583060
references: Hepatology. 2011 Dec;54(6):2089-98
references: 21809359
references: J Autoimmun. 2009 May-Jun;32(3-4):246-53
references: 19345069
references: BMC Syst Biol. 2013;7:104
references: 24138927
references: Gastroenterology. 1995 Dec;109(6):1969-76
references: 7498663
references: Exp Ther Med. 2013 Nov;6(5):1265-1270
references: 24223656
references: J Biol Chem. 2010 Jan 1;285(1):216-25
references: 19903813
references: Hepatology. 2010 Mar;51(3):881-90
references: 20146264
references: J Cell Biochem. 2010 Aug 1;110(5):1155-64
references: 20564213
references: World J Gastroenterol. 2012 Nov 21;18(43):6189-96
references: 23180938
references: Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):101-8
references: 23296249
references: J Biol Chem. 2007 Mar 16;282(11):8256-64
references: 17220301
references: Clin Exp Immunol. 2009 Aug;157(2):261-70
references: 19604266
references: Hepatology. 2012 Aug;56(2):687-97
references: 22383162
references: Oncogene. 2007 Sep 13;26(42):6133-40
references: 17404574
references: Pediatr Transplant. 2005 Oct;9(5):646-51
references: 16176425
references: Nephrol Dial Transplant. 2014 Apr;29(4):755-63
references: 23787546
references: EMBO J. 2004 Apr 7;23(7):1657-68
references: 15029248
references: Gastroenterology. 2009 Jun;136(7):2304-2315.e1-4
references: 19272382
references: J Pediatr Surg. 2009 Mar;44(3):500-7
references: 19302848
references: Hepatology. 1997 Jan;25(1):12-7
references: 8985258
references: Nature. 2005 Dec 1;438(7068):685-9
references: 16258535
references: Gene. 2012 Feb 1;493(1):44-51
references: 22146319
references: Gastroenterology. 2006 Jun;130(7):2113-29
references: 16762633
references: Hepatology. 2006 Feb;43(2):266-75
references: 16440368
references: Oncol Rep. 2013 May;29(5):2046-52
references: 23446431
references: PLoS One. 2012;7(2):e30250
references: 22363424
references: Gastroenterology. 2004 Nov;127(5):1565-77
references: 15521023
references: Immunol Cell Biol. 2008 Aug-Sep;86(6):497-505
references: 18504452
references: BMC Genomics. 2008;9:624
references: 19102782
references: HPB (Oxford). 2013 Apr;15(4):260-4
references: 23458262
references: J Biol Chem. 2007 Sep 28;282(39):28929-38
references: 17660297
references: Gastroenterology. 2007 Apr;132(4):1504-14
references: 17408653
references: Trends Mol Med. 2014 May;20(5):261-70
references: 24506938
references: Gene Expr. 2014;16(2):93-9
references: 24801170
references: World J Gastroenterol. 2009 Sep 14;15(34):4240-62
references: 19750567
references: J Infect Dis. 2010 Jul 1;202(1):125-35
references: 20486857
references: Gastroenterology. 2011 Jul;141(1):378-88, 388.e1-4
references: 21440549
references: J Immunol. 2009 Aug 1;183(3):1617-24
references: 19592657
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: PLoS One. 2013;8(10):e77623
references: 24147037
references: Cell Physiol Biochem. 2013;32(5):1331-41
references: 24280681
references: FEBS J. 2012 Jul;279(13):2393-8
references: 22540680
references: Hepatology. 2009 Feb;49(2):618-26
references: 19127519
references: Hepatology. 2011 Jan;53(1):209-18
references: 20890893
references: J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):366-9
references: 22732895
references: World J Gastroenterol. 2006 Jun 14;12(22):3496-511
references: 16773707
references: Mol Cancer Res. 2014 Jun;12(6):890-900
references: 24699315
references: J Hepatol. 1998 Sep;29(3):409-16
references: 9764987
references: Nat Rev Drug Discov. 2010 Oct;9(10):775-89
references: 20885409
references: PLoS One. 2009;4(10):e7511
references: 19841744
references: Hepatology. 2002 Jun;35(6):1513-21
references: 12029638
references: Mol Carcinog. 2013 Apr;52(4):297-303
references: 22213236
references: Mol Carcinog. 2013 Apr;52(4):286-96
references: 22213145
references: Gut. 2002 Nov;51 Suppl 6:VI1-9
references: 12376491