title: Honokiol decreases intra-abdominal adhesion formation in a rat model.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model.
  
  
  METHODS
  This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way.
  
  
  RESULTS
  Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008).
  
  
  CONCLUSIONS
  Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.
authors: Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors: Elif
authors: E
authors: Agacayak
authors: Senem Yaman
authors: SY
authors: Tunc
authors: Mehmet Sait
authors: MS
authors: Icen
authors: Ulaş
authors: U
authors: Alabalik
authors: Fatih Mehmet
authors: FM
authors: Findik
authors: Hatice
authors: H
authors: Yuksel
authors: Talip
authors: T
authors: Gul
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D017705:Lignans / Q000494:pharmacology*; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols