title: Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: implications for differential susceptibility.
abstract: Genetic moderation of interpersonal psychotherapy (IPT) efficacy for economically disadvantaged women with major depressive disorder was examined. Specifically, we investigated whether genotypic variation in corticotropin releasing hormone receptor 1 (CRHR1) and the linked polymorphic region of the serotonin transporter gene (5-HTTLPR) moderated effects of IPT on depressive symptoms over time. We also tested genotype moderation of IPT mechanisms on social adjustment and perceived stress. Non-treatment-seeking urban women at or below the poverty level with infants were recruited from the community (N = 126; M age = 25.33 years, SD = 4.99; 54.0% African American, 22.2% Caucasian, and 23.8% Hispanic/biracial) and randomized to individual IPT or Enhanced Community Standard groups. The results revealed that changes in depressive symptoms over time depended on both intervention group and genotypes (5-HTTLPR and CRHR1). Moreover, multiple-group path analysis indicated that IPT improved depressive symptoms, increased social adjustment, and decreased perceived stress at posttreatment among women with the 0 copies of the CRHR1 TAT haplotype only. Finally, improved social adjustment at postintervention significantly mediated the effect of IPT on reduced depressive symptoms at 8 months postintervention for women with 0 copies of the TAT haplotype only. Post hoc analyses of 5-HTTLPR were indicative of differential susceptibility, albeit among African American women only.
authors: University of Minnesota Institute of Child Development.
authors: Dante
authors: D
authors: Cicchetti
authors: University of Rochester Mt. Hope Family Center.
authors: Sheree L
authors: SL
authors: Toth
authors: University of Rochester Mt. Hope Family Center.
authors: Elizabeth D
authors: ED
authors: Handley
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology / Q000628:therapy*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007223:Infant; D009034:Mother-Child Relations / Q000523:psychology; D009035:Mothers / Q000523:psychology*; D011110:Polymorphism, Genetic / Q000235:genetics; D011203:Poverty / Q000523:psychology*; D011613:Psychotherapy; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D016896:Treatment Outcome; D055815:Young Adult; D000099052:CRF Receptor, Type 1
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D000099052:CRF Receptor, Type 1
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