title: Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models.
abstract: Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one of phytoestrogens that have structures similar to the principal mammalian estrogen. It has diverse biological functions including chemopreventive properties against cancers. Anticancer efficacies of genistein have been related with the epidemiological observations indicating that the incidence of some cancers is much lower in Asia, where diets are rich in soyfoods, than Western countries. This review deals with in vivo anticancer activities of genistein identified in animal studies being divided into its effects on carcinogenesis and cancer progression. Because animal studies have advantages in designing the experiments to suit the goals, they imply diverse information on the anticancer activity of genistein. The in vivo animal studies have adopted the specific animal models according to a developmental stage of cancer to prove the anticancer efficacies of genistein against diverse types of cancer. The numerous previous studies insist that genistein effectively inhibits carcinogenesis in the DMBA-induced animal cancer models by reducing the incidence of adenocarcinoma and cancer progression in the transgenic and xenograft animal models by suppressing the tumor growth and metastatic transition. Although the protective effect of genistein against cancer has been controversial, genistein may be a candidate for chemoprevention of carcinogenesis and cancer progression and may deserve to be the central compound supporting the epidemiological evidence.
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: Seung-Hee
authors: SH
authors: Kim
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: Cho-Won
authors: CW
authors: Kim
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: So-Ye
authors: SY
authors: Jeon
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: Ryeo-Eun
authors: RE
authors: Go
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: Kyung-A
authors: KA
authors: Hwang
authors: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors: Kyung-Chul
authors: KC
authors: Choi
keywords: Genistein; cancer progression; carcinogenesis; transgenic mouse; xenograft
references: Nutr Cancer. 2003;47(2):141-7
references: 15087266
references: Oncogene. 1996 Jul 4;13(1):97-104
references: 8700559
references: Eur J Pharmacol. 2013 Jan 5;698(1-3):31-8
references: 23178528
references: Jpn J Cancer Res. 2001 Jul;92(7):726-34
references: 11473722
references: Biochem Pharmacol. 2014 Jan 1;87(1):150-61
references: 23817077
references: J Agric Food Chem. 2001 Jun;49(6):3024-33
references: 11410004
references: Toxicol Appl Pharmacol. 2013 Nov 1;272(3):637-46
references: 23933164
references: Int J Mol Sci. 2012;13(1):56-70
references: 22312238
references: Int J Oncol. 2007 Jun;30(6):1521-8
references: 17487374
references: J Cell Physiol. 2013 Mar;228(3):513-21
references: 22777826
references: Eur J Nutr. 2009 Jun;48(4):213-20
references: 19234664
references: PLoS One. 2014 May 15;9(5):e96155
references: 24830850
references: Anticancer Agents Med Chem. 2012 Mar;12(3):271-81
references: 22043996
references: Prostate. 2013 Nov;73(15):1681-9
references: 23999913
references: Cancer Res. 2006 Feb 1;66(3):1851-8
references: 16452247
references: Int J Clin Exp Pathol. 2014 Mar 15;7(4):1687-94
references: 24817965
references: J Natl Cancer Inst. 2006 Sep 20;98(18):1275-84
references: 16985246
references: Phytochemistry. 2002 Jun;60(3):205-11
references: 12031439
references: J Carcinog. 2007 Mar 16;6:3
references: 17367528
references: Toxicol Pathol. 2015 Apr;43(3):435-48
references: 24713318
references: Inflamm Res. 2003 Aug;52(8):341-6
references: 14504672
references: Cell Physiol Biochem. 2013;31(1):80-91
references: 23363563
references: Carcinogenesis. 1995 Nov;16(11):2833-40
references: 7586206
references: Cell. 2000 Jan 7;100(1):57-70
references: 10647931
references: Nutr Cancer. 2005;53(1):82-90
references: 16351510
references: Eur J Cancer. 2004 Apr;40(6):852-7
references: 15120041
references: Int J Cancer. 2007 Jun 1;120(11):2491-8
references: 17304503
references: Carcinogenesis. 2007 Aug;28(8):1710-7
references: 17468512
references: Am J Respir Crit Care Med. 2003 Jan 15;167(2):185-92
references: 12406820
references: Cancer Res. 2008 Mar 15;68(6):2024-32
references: 18339885
references: Arh Hig Rada Toksikol. 2010 Dec;61(4):445-53
references: 21183436
references: Stem Cell Res Ther. 2013;4(6):146
references: 24331293
references: Prostate. 2013 Dec;73(16):1747-60
references: 24038102
references: J Clin Endocrinol Metab. 1998 Jul;83(7):2223-35
references: 9661587
references: Oncol Rep. 1998 Nov-Dec;5(6):1541-5
references: 9769402
references: Cancer Res. 2009 Apr 15;69(8):3695-703
references: 19351854
references: Anticancer Agents Med Chem. 2012 Dec;12(10):1306-13
references: 22583409
references: Nat Protoc. 2007;2(2):247-50
references: 17406581
references: Environ Health Perspect. 1995 Oct;103 Suppl 7:103-12
references: 8593855
references: Radiat Res. 2006 Jul;166(1 Pt 1):73-80
references: 16808622
references: Ann Med. 2005;37(6):423-38
references: 16203615
references: Anticancer Res. 2013 Jan;33(1):39-44
references: 23267126
references: Cancer Res. 2005 Apr 15;65(8):3396-403
references: 15833874
references: Nutr Cancer. 2009;61(5):598-606
references: 19838933
references: Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3439-43
references: 7724580
references: AAPS J. 2013 Oct;15(4):991-1000
references: 23824838
references: PLoS One. 2011;6(5):e20034
references: 21603581
references: Food Funct. 2013 Feb;4(2):200-12
references: 23160185
references: J Tradit Complement Med. 2012 Apr;2(2):96-104
references: 24716121
references: Evid Based Complement Alternat Med. 2014;2014:293961
references: 24738003
references: Proc Soc Exp Biol Med. 1995 Jan;208(1):120-3
references: 7892285
references: Prostate. 2003 May 15;55(3):219-37
references: 12692788
references: Curr Med Chem. 2010;17(27):3007-18
references: 20629630
references: Nutr Cancer. 2001;41(1-2):75-81
references: 12094632
references: Jpn J Pharmacol. 2001 Jul;86(3):302-9
references: 11488430
references: Cancer Genomics Proteomics. 2009 Mar-Apr;6(2):85-92
references: 19451092
references: Ecotoxicol Environ Saf. 2002 May;52(1):38-45
references: 12051806
references: Br J Cancer. 1999 Aug;80(11):1682-8
references: 10468283
references: Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(11):901-4
references: 17048629
references: FASEB J. 2005 Oct;19(12):1755-7
references: 16107535
references: Int J Cancer. 1998 Sep 11;77(6):887-94
references: 9714059
references: Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):901-6
references: 8922298
references: Cancer Metastasis Rev. 2010 Sep;29(3):465-82
references: 20730632
references: Carcinogenesis. 2004 May;25(5):741-8
references: 14729590
references: Yale J Biol Med. 2006 Dec;79(3-4):95-103
references: 17940619
references: Annu Rev Pathol. 2011;6:95-119
references: 20936938
references: Breast Cancer. 2010 Apr;17(2):80-5
references: 19806428
references: J Nutr. 2002 Oct;132(10):3186-90
references: 12368416
references: Carcinogenesis. 1996 Jul;17(7):1451-7
references: 8706248
references: Mol Carcinog. 2007 Jul;46(7):534-42
references: 17295235
references: Oncology. 2001;61 Suppl 2:1-13
references: 11694782
references: In Vivo. 2000 Mar-Apr;14(2):357-62
references: 10836210
references: Transgenic Res. 2012 Apr;21(2):327-49
references: 21800101
references: Carcinogenesis. 1998 Dec;19(12):2151-8
references: 9886571
references: Jpn J Cancer Res. 1999 Apr;90(4):393-8
references: 10363576
references: Acta Med Indones. 2010 Jan;42(1):36-42
references: 20305331
references: J Gastrointestin Liver Dis. 2013 Sep;22(3):305-10
references: 24078988
references: Nutr Rev. 2009 Jul;67(7):398-415
references: 19566600
references: Eur J Pharmacol. 2011 Jan 15;650(2-3):694-702
references: 21050844
references: Toxicol Pathol. 1996 Jul-Aug;24(4):502-4
references: 8864193
references: J Nutr. 2005 May;135(5):989-95
references: 15867270
references: Genes Nutr. 2013 Jul;8(4):383-90
references: 23108595
references: N Engl J Med. 2008 Jan 31;358(5):502-11
references: 18234754
references: Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10578-82
references: 1359541