title: [Lynch syndrome and risk of prostate cancer; review of the literature].
abstract: BACKGROUND
  The association between Lynch syndrome and prostate cancer has been studied. Recent studies report an association between these two diseases.
  
  
  METHODS
  Literature review based on PubMed search was performed using the following keywords: Lynch syndrome and prostate cancer.
  
  
  RESULTS
  Eight articles analyzing cohorts of subjects carrying Lynch syndrome were analysed including 6786 patients with 175 cancers. Prostate cancers were more frequent with a standardized incidence ratio (SIR) from 0.93 (95% CI: 0.19-2.7) and 5.9 (95% CI 4.1-17.1) and occurs at a younger age than in the general population mainly for mutations in the MSH2 gene.
  
  
  CONCLUSIONS
  Prostate cancer seem more frequent and occur earlier in individuals harboring a mutation in the MSH2 gene while it does not appear to be any difference compared to the general population for other mutations in Lynch syndrome.
authors: Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: fmaillard59@gmail.com.
authors: F
authors: F
authors: Maillard
authors: Service de génétique clinique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinee, 59037 Lille, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France. Electronic address: sylvie.manouvrier@chru-lille.fr.
authors: S
authors: S
authors: Manouvrier
authors: Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: biardeau.xavier@gmail.com.
authors: X
authors: X
authors: Biardeau
authors: Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: adil-ouzzane@orange.fr.
authors: A
authors: A
authors: Ouzzane
authors: Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France; Faculté de médecine H.-Warembourg, université de Lille II, avenue Eugène-Avinée, 59045 Lille cedex, France. Electronic address: arnauldvillers@icloud.com.
authors: A
authors: A
authors: Villers
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D019317:Evidence-Based Medicine; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D009154:Mutation; D017410:Practice Guidelines as Topic; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D012307:Risk Factors
chemical_list: C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein
keywords: Cancer de prostate; Déficience du système mismatch repair; Instabilité des microsatellites; Lynch syndrome; Microsatellite instability; Mismatch repair deficiency; Prostate cancer; Syndrome de Lynch