title: An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats.
abstract: Diabetes is a metabolic disorder which affects whole body systems including reproductive system. Diabetes is also a contributing factor to infertility. Metformin is one of the most common drugs to control hyperglycemia. In this study, 36 adult Sprague-Dawley female rats (170-210 g) were divided into 3 groups (control, diabetic and diabetic-treated by metformin). In second and third groups, diabetes was induced by streptozotocin injection (45 mg kg(-1), IP) and the third group was treated by metformin hydrochloride (100 mg kg(-1) day(-1), PO) for 8 weeks. Body weights were compared and blood glucose, gonadotropins and sexual hormones were measured. In diabetic group the blood glucose level significantly (P < 0.05) increased in comparison with that of control and metformin-treated diabetic rats. The results also revealed that, in the untreated diabetic rats, the mean body weights and pituitary-gonadal axis hormones were significantly (P < 0.05) reduced in comparison with the control. Although there were significant (P < 0.05) reduction in mean body weights in metformin-treated diabetic rats, reduction in pituitary-gonadal axis hormones was not as sharp as in untreated diabetic rats and only level of progesterone was significantly (P < 0.05) reduced in comparison with the control. The results of this investigation revealed that there was a clear relationship between experimental diabetes with body weight and pituitary-gonadal axis hormones, and treatment with metformin relatively restored diabetic complications.
authors: Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;
authors: Pouya
authors: P
authors: Pournaghi
authors: Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;
authors: Rajab-Ali
authors: RA
authors: Sadrkhanlou
authors: Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;
authors: Shapour
authors: S
authors: Hasanzadeh
authors: Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors: Azadeh
authors: A
authors: Foroughi
keywords: Body weight; Diabetes; Hormone; Metformin; Rat
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