title: Prevention of retinoic acid-induced osteoporosis in mice by isoflavone-enriched soy protein.
abstract: BACKGROUND
  A novel soy protein aggregate enriched with isoflavones (SPA-IS), a mixture of soy protein and isoflavones (Mix), isoflavones (IS), and the soy protein were obtained to investigate the preventive effects on osteoporosis induced by retinoic acid in Kunming mice.
  
  
  RESULTS
  The serum osteocalcin levels in the Mix and SPA-IS groups decreased compared with the model group (mice showing retinoic acid-induced osteoporosis) (P < 0.05). The trabecular analysis results showed an increased preventive effect of the SPA-IS group over the Mix group, the IS group, and the soy protein group. The results of both left tibial maximum load and the 4th lumbar structural strength differ between the IS and the SPA-IS groups.
  
  
  CONCLUSIONS
  The SPA-IS exhibited obvious oestrogenic activities on retinoic acid-induced osteoporosis in Kunming mice compared to Mix, IS, and soy protein. The results suggest that there is a potential use for SPA-IS in the treatment of osteoporosis induced by intake of retinoic acid. The improvement of bone indicators might be attributed to the formation of aggregate particles and the improvement of IS solubility.
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Juan
authors: J
authors: Yang
authors: Academy of State Administration of Grain, Beijing 100037, P.R. China.
authors: Nana
authors: N
authors: Wu
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Jie
authors: J
authors: Peng
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Xiaoquan
authors: X
authors: Yang
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Jian
authors: J
authors: Guo
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Shouwei
authors: S
authors: Yin
authors: Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
authors: Jinmei
authors: J
authors: Wang
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005260:Female; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D048789:Phytoestrogens / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012995:Solubility; D030262:Soybean Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*; D014212:Tretinoin
chemical_list: D007529:Isoflavones; D048789:Phytoestrogens; D010936:Plant Extracts; D030262:Soybean Proteins; D015675:Osteocalcin; D014212:Tretinoin
keywords: aggregate; isoflavones; mice; osteoporosis; retinoic acid; soy protein