title: Influence of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement on lipid profile in normal and diet-induced hypercholesterolemic rats.
abstract: BACKGROUND
  Zincovit tablet is combination of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement.
  
  
  OBJECTIVE
  To investigate the influence of single combined formulation of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement tablets (Zincovit) on lipid profile in normal and diet-induced hypercholesterolemic rats.
  
  
  METHODS
  Anti-hyperlipidemic activity of combined formulation of grape seed extract and Zincovit tablets doses ranged from 40 to 160 mg/kg, p.o. was evaluated in normal and diet-induced hypercholesterolemic rats.
  
  
  RESULTS
  Hypercholesterolemic animals treated with combined formulation of grape seed extract and Zincovit tablets (nutritional food supplement) at 40, 80 and 160 mg/kg exhibited drastic decrease in serum triglycerides, total cholesterol, LDL-C, VLDL-C and rise of HDL-C in comparison to hypercholesterolemic control group animals. The anti-hyperlipidemic effect of single combined formulation of grape seed extract and Zincovit tablet was comparable with the standard drug atorvastatin treated animals and the variations were statistically non-significant. There was no significant impact of combined formulation of grape seed extract and Zincovit tablets on lipid profile among normal animals in comparison with normal control group.
  
  
  CONCLUSIONS
  The present study demonstrated that the single combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against diet-induced hypercholesterolemia in Wistar rats.
authors: Lecturer, Department of Pharmacology, Melaka Manipal Medical College, Manipal University , Manipal, Karnataka, India .
authors: Shakta Mani
authors: SM
authors: Satyam
authors: Professor and Head, Department of Pharmacology, Kasturba Medical College, Manipal University , Manipal, Karnataka, India .
authors: Laxminarayana Kurady
authors: LK
authors: Bairy
authors: Lecturer, Department of Pharmacology, Nepalgunj Medical College , Nepalgunj, Chispani (Nepal) .
authors: Rajadurai
authors: R
authors: Pirasanthan
keywords: Antioxidant; Atherosclerosis; Atorvastatin; Cardiovascular disease; Grape seed extract; Reactive oxygen species; Zincovit tablets
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