title: Fighting against kidney diseases with small interfering RNA: opportunities and challenges.
abstract: The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled silence, as well as selecting therapeutic targets, were addressed as well.
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. esuperyc@163.com.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, China. esuperyc@163.com.
authors: Cheng
authors: C
authors: Yang
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. zhangchaomed@126.com.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, China. zhangchaomed@126.com.
authors: Chao
authors: C
authors: Zhang
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. zzt_queen@126.com.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, China. zzt_queen@126.com.
authors: Zitong
authors: Z
authors: Zhao
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. tyzhu_dr@163.com.|Shanghai Key Laboratory of Organ Transplantation, Shanghai, China. tyzhu_dr@163.com.
authors: Tongyu
authors: T
authors: Zhu
authors: Transplant Group, Department of Infection, Immunity and Inflammation, University Hospitals of Leicester, University of Leicester, Leicester, UK. by5@le.ac.uk.|Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China. by5@le.ac.uk.|Basic Medical Research Centre, Medical School of Nantong University, Nantong, China. by5@le.ac.uk.
authors: Bin
authors: B
authors: Yang
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques; D006801:Humans; D007674:Kidney Diseases / Q000628:therapy*; D034741:RNA, Small Interfering / Q000378:metabolism*; D057170:Translational Research, Biomedical
chemical_list: D034741:RNA, Small Interfering
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