title: Antibacterial effect of butyryl alkannin from Arnebia euchroma against vancomycin-resistant pathogens of Enterococcus faecalis causing urinary tract infections.
abstract: This study was carried out to investigate the biomedicinal potential of a bioactive marker component, butyryl alkannin, isolated from n-hexane root extract of Arnebia euchroma against various vancomycin-resistant Enterococcus (VRE) isolates of Enterococcus faecalis causing urinary tract infections. As a result, butyryl alkannin showed significant antibacterial activity against multidrug-resistant E. faecalis pathogens of VRE as minimum inhibitory concentration values which were found in the range of 3.13 to 6.26 μg ml(-1). The findings of this study justify biological and biomedicinal potential of butyryl alkannin compound as confirmed by its higher and significant antibacterial efficacy against VRE isolates of E. faecalis as compared to standard antibiotic vancomycin.
authors: a Department of Botany and Microbiology , Gurukul Kangri University , Haridwar 249-404 , Uttrakhand , India.
authors: Lokesh Kumar
authors: LK
authors: Singh
authors: a Department of Botany and Microbiology , Gurukul Kangri University , Haridwar 249-404 , Uttrakhand , India.
authors: Dinesh Kumar
authors: DK
authors: Maheshwari
authors: b Department of Food Science and Technology , Yeungnam University , Gyeongsan, Gyeongbuk 712-749 , Republic of Korea.
authors: Shruti
authors: S
authors: Shukla
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014552:Urinary Tract Infections / Q000382:microbiology; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D010936:Plant Extracts; C018204:alkannin
keywords: Arnebia euchroma; butyryl alkannin; urinary tract infection; vancomycin-resistant Enterococcus (VRE)