title: Video-game based therapy performed by children with cerebral palsy: a cross-over randomized controlled trial and a cross-sectional quantitative measure of physical activity.
abstract: BACKGROUND
  Previous studies reported controversial results about the efficacy of video-game based therapy (VGT) in improving neurorehabilitation outcomes in children with cerebral palsy (CP).
  
  
  OBJECTIVE
  Primary aim was to investigate the effectiveness of VGT with respect to conventional therapy (CT) in improving upper limb motor outcomes in a group of children with CP. Secondary aim was to quantify if VGT leads children to perform a higher number of movements.
  
  
  METHODS
  A cross-over randomized controlled trial (RCT) for investigating the primary aim and a cross-sectional study for investigating the secondary aim of this study.
  
  
  METHODS
  Outpatients.
  
  
  METHODS
  
  
  
  METHODS
  clinical diagnosis of CP, age between 4 and 14 years, level of GMFC between I and IV.
  
  
  METHODS
  QI<35, severe comorbidities, incapacity to stand even with an external support.
  
  
  METHODS
  Twenty-two children with CP (6.89±1.91-year old) were enrolled in a cross-over RCT with 16 sessions of VGT (using Xbox with Kinect device) and then 16 of CT or vice versa. Upper limb functioning was assessed using the Quality of Upper Extremities Skills Test (QUEST) and hand abilities using Abilhand-kids score. According to the secondary aim of this study a secondary cross-sectional study has been performed. Eight children with CP (6.50±1.60-year old) were enrolled into a trial in which five wireless triaxial accelerometers were positioned on their forearms, legs and trunk for quantifying the physical activity during VGT vs. CT.
  
  
  RESULTS
  QUEST scores significantly improved only after VGT (P=0.003), and not after CT (P=0.056). The reverse occurred for Abilhand-kids scores (P=0.165 vs. P=0.013, respectively). Quantity of performed movements was three times higher in VGT than in CT (+198%, P=0.027).
  
  
  CONCLUSIONS
  VGT resulted effective in improving the motor functions of upper limb extremities in children with CP, conceivably for the increased quantity of limb movements, but failed in improving the manual abilities for performing activities of daily living which benefited more from CT.
  
  
  CONCLUSIONS
  VGT performed using the X-Box with Kinect device could enhance the number of upper limb movements in children with CP during rehabilitation and in turn improving upper limb motor skills, but CT remained superior for improving performances in manual activities of daily living.
authors: Department of Child Neurorehabilitation, I.R.C.C.S. Fondazione Santa Lucia, Rome, Italy - m.iosa@hsantalucia.it.
authors: L
authors: L
authors: Zoccolillo
authors: D
authors: D
authors: Morelli
authors: F
authors: F
authors: Cincotti
authors: L
authors: L
authors: Muzzioli
authors: T
authors: T
authors: Gobbetti
authors: S
authors: S
authors: Paolucci
authors: M
authors: M
authors: Iosa
mesh_terms: D000293:Adolescent; D002547:Cerebral Palsy / Q000503:physiopathology* / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D034941:Upper Extremity / Q000503:physiopathology*; D018910:Video Games