title: Self-assembling polymer micelle/clay nanodisk/doxorubicin hybrid injectable gels for safe and efficient focal treatment of cancer.
abstract: The purpose of this study was to fabricate a safe and effective doxorubicin (DOX)-delivery system for focal cancer chemotherapy. A novel biodegradable injectable gel was developed through self-assembly of poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer micelles, clay nanodisks (CNDs), and DOX. We discovered that DOX loaded in the hybrid gels acts as an anticancer drug and as a building block to organize new gel networks. Accordingly, long-term sustained release of DOX from hybrid injectable gels without initial burst release was achieved. Moreover, it was revealed that the DOX incorporated into gel networks controls its own release profile. This hybrid injectable gel is a self-controlled drug release system, which is a novel concept in controlled drug release. Importantly, a single injection of PLGA-PEG-PLGA/CND/DOX hybrid gel provides long-term sustained antitumor activity in vivo against human xenograft tumors in mice, suggesting the potential of hybrid gels as a valuable local DOX-delivery platform for cancer focal therapy.
authors: Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology, Konan University , 7-1-20 minatojima-minamimachi, Kobe 650-0047, Japan.
authors: Koji
authors: K
authors: Nagahama
authors: Daichi
authors: D
authors: Kawano
authors: Naho
authors: N
authors: Oyama
authors: Ayaka
authors: A
authors: Takemoto
authors: Takayuki
authors: T
authors: Kumano
authors: Junji
authors: J
authors: Kawakami
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D000077215:Clay; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers / Q000008:administration & dosage*; D005782:Gels; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008807:Mice, Inbred BALB C; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D058105:Polymerization; D011108:Polymers / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000538:Aluminum Silicates; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D005782:Gels; D008823:Micelles; D011108:Polymers; D004317:Doxorubicin; D000077215:Clay