title: Patients with atrial fibrillation complicated by coronary artery disease. Is a single value of sensitive cardiac troponin I on admission enough?
abstract: BACKGROUND
  Atrial fibrillation (AF) is the most common arrhythmia in the general population. Cardiac troponin I (cTnI) can be elevated in patients with AF without coexisting coronary artery disease (CAD). The aim of this study was to characterize the diagnostic accuracy and clinical usefulness of a cTnI assay for the diagnosis of CAD in patients with AF.
  
  
  METHODS
  Patients with AF undergoing coronary angiography were included in the study. The workflow chart encompassed measuring of cTnI in all patients at admission and after 6 h.
  
  
  RESULTS
  Patients with CAD were older (73.8 ± 7.6 vs. 65.3 ± 12.9 years) than patients without CAD; for all other characteristics, no significant differences were observed. Of the patients, 39 had CAD [12 patients one-vessel disease (VD), 14 patients 2-VD, 13 patients 3-VD] and 16 patients had acute myocardial infarction and were undergoing percutaneous coronary intervention. There was no significant difference in cTnI concentrations between patients without and with CAD at admission (0.02 vs. 0.03 ng/ml, respectively); however, a difference was noted after 6 h (0.03 vs. 0.06 ng/ml, respectively).
  
  
  CONCLUSIONS
  AF patients both without and with CAD showed similar cTnI concentrations at admission. A second validation of cTnI is mandatory for all patients.
authors: Medizinische Klinik 2, Universtität Giessen, Klinikstr. 33, 35392, Giessen, Germany, dirk.bandorski@hkw.med.uni-giessen.de.
authors: Dirk
authors: D
authors: Bandorski
authors: Harilaos
authors: H
authors: Bogossian
authors: Olaf
authors: O
authors: Braun
authors: Gerrit
authors: G
authors: Frommeyer
authors: Markus
authors: M
authors: Zarse
authors: Reinhard
authors: R
authors: Höltgen
authors: Christoph
authors: C
authors: Liebetrau
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I
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