title: Evaluation of gynecologic cancer with MR imaging, 18F-FDG PET/CT, and PET/MR imaging.
abstract: MR imaging and (18)F-FDG PET/CT play central and complementary roles in the care of patients with gynecologic cancer. Because treatment often requires combinations of surgery, radiotherapy, and chemotherapy, imaging is central to triage and to determining prognosis. This article reviews the use of the 2 imaging modalities in the initial evaluation of 3 common cancers: uterine cervical, uterine endometrial, and epithelial ovarian. Imaging features that affect management are highlighted, as well as the relative strengths and weaknesses of the 2 modalities. Use of imaging after initial therapy to assess for recurrence and to plan salvage therapy is described. Newer functional and molecular techniques in MR imaging and PET are evaluated. Finally, we describe our initial experience with PET/MR imaging, an emerging technology that may prove to be a mainstay in personalized gynecologic cancer care.
authors: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts slee0@partners.org.
authors: Susanna I
authors: SI
authors: Lee
authors: Department of Radiology, University of Naples Parthenope and SDN Istituto Ricerca Diagnostica Nucleare, Naples, Italy.
authors: Onofrio A
authors: OA
authors: Catalano
authors: Department of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
authors: Farrokh
authors: F
authors: Dehdashti
mesh_terms: D056831:Coordination Complexes; D004958:Estradiol / Q000031:analogs & derivatives; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local; D009942:Organometallic Compounds / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography; D011379:Prognosis; D016879:Salvage Therapy; D013882:Thiosemicarbazones / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D056831:Coordination Complexes; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); D019788:Fluorodeoxyglucose F18; D004958:Estradiol; C043436:16-fluoroestradiol
keywords: 16α-18F-fluoro-17β-estradiol PET; Cu-labeled diacetyl-bis (N4-methylthiosemicarbazone) PET; diffusion weighted imaging; dynamic contrast enhanced MRI; perfusion MRI