title: [Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF].
abstract: BACKGROUND
  Colchicine is the mainstay for the treatment of FMF, which is an auto-inflammatory disease mainly with relapsing polyserositis. Despite daily doses of 2mg or more each day, approximately 5% to 10% of the patients continue to suffer from its attacks. In this study, we aimed to investigate the depression and attack features in patients with FMF who have colchicine resistance (CR).
  CR was defined for FMF patients with 2 or more attacks within the last 6 months period while using 2mg/day colchicine. Eighteen patients (9 Female/9 Male) were enrolled into the CR group and 41 patients were enrolled into the control group (12 Male/29 Female). Demographic, clinical e laboratory findings, treatment adherence, and the Beck Depression Inventory (BDI) scores were evaluated.
  
  
  RESULTS
  The age of onset of FMF was significantly lower in the CR group (12.3 yrs vs. 16.9 yrs, P=0.03). Disease duration was longer in the CR group (P=0.01). Abdominal and leg pain due to exercise were significantly more frequent in the CR group versus controls (83% vs. 51%; P=0.02 e 88% vs. 60%; P=0.04, respectively). Patients with BDI scores over 17 points were more frequent in the CR group compared to controls (50% vs. 34.1%; P<0.001).
  
  
  CONCLUSIONS
  We found that: (1) the age of disease onset was lower and (2) the disease duration was longer in CR group. Pleuritic attacks, hematuria e proteinuria were more frequent in CR patients. We propose that depression is an important factor to consider in the susceptibility to CR.
authors: Universidade Sutcu Imam, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Kahramanmaras, Turquia. Electronic address: gozdeyildirimcetin@gmail.com.
authors: Gozde Yildirim
authors: GY
authors: Cetin
authors: Universidade Pamukkale, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Denizli, Turquia.
authors: Ayse
authors: A
authors: Balkarli
authors: Universidade Sutcu Imam, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Kahramanmaras, Turquia.
authors: Ali Nuri
authors: AN
authors: Öksüz
authors: Universidade Gaziantep, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Gaziantep, Turquia.
authors: Gezmiş
authors: G
authors: Kimyon
authors: Universidade Gaziantep, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Gaziantep, Turquia.
authors: Yavuz
authors: Y
authors: Pehlivan
authors: Universidade Sutcu Imam, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Kahramanmaras, Turquia.
authors: Ozlem
authors: O
authors: Orhan
authors: Universidade Gaziantep, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Gaziantep, Turquia.
authors: Bunyamin
authors: B
authors: Kisacik
authors: Universidade Pamukkale, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Denizli, Turquia.
authors: Veli
authors: V
authors: Cobankara
authors: Universidade Ondokuz Mayis, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Nefrologia, Samsun, Turquia.
authors: Hayriye
authors: H
authors: Sayarlioglu
authors: Universidade Gaziantep, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Reumatologia, Gaziantep, Turquia.
authors: Ahmet Mesut
authors: AM
authors: Onat
authors: Universidade Ondokuz Mayis, Faculdade de Medicina, Departamento de Medicina Interna, Divisão de Nefrologia, Samsun, Turquia.
authors: Mehmet
authors: M
authors: Sayarlioglu
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D003863:Depression / Q000150:complications; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies
chemical_list: D003078:Colchicine
keywords: Colchicine resistance; Depression; Depressão; Familial Mediterranean fever; Febre familiar do Mediterrâneo; Resistência à Colchicina; Tratamento; Treatment