title: Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma.
abstract: The timely diagnosis and effective treatment are essential for improving the survival and prognosis of hepatocellular carcinoma (HCC) patients. Alpha-fetoprotein (AFP) is the most widely used biomarker for diagnosis of HCC, but the low sensitivity and specificity limits its clinical application. In this study, we evaluated the diagnostic capability of the combination of AFP with two novel potential biomarkers, dickkopf-1 (DKK1) and osteopontin (OPN), for HCC in 390 participants including 89 patients with HCC, 36 patients with liver cirrhosis, 65 patients with chronic hepatitis B, and 200 health controls. We found the combination of all three markers as a panel showed a better diagnostic performance than that of AFP alone, with increased AUC [0.948 (95% CI 0.921-0.968) vs. 0.831 (95% CI 0.790-0.867)] and sensitivity (88.76 vs. 71.91%). Moreover, this combination showed a great improvement in diagnosing early-stage HCC patients. In conclusion, the combined use of AFP, DKK1, and OPN as a biomarker panel could enhance the diagnostic ability for HCC.
authors: Shanghai Medical College of Fudan University, No. 138 Yi-Xueyuan Road, Shanghai, 200032, China.
authors: Tianxiang
authors: T
authors: Ge
authors: Qiujin
authors: Q
authors: Shen
authors: Ning
authors: N
authors: Wang
authors: Yurong
authors: Y
authors: Zhang
authors: Zhouhong
authors: Z
authors: Ge
authors: Wei
authors: W
authors: Chu
authors: Xiufang
authors: X
authors: Lv
authors: Fengbo
authors: F
authors: Zhao
authors: Weifeng
authors: W
authors: Zhao
authors: Jia
authors: J
authors: Fan
authors: Wenxin
authors: W
authors: Qin
mesh_terms: D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis*; D016022:Case-Control Studies; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000509:alpha-Fetoproteins; D053495:Osteopontin
references: Hepatology. 2011 Mar;53(3):1020-2
references: 21374666
references: Gastroenterology. 2009 Jul;137(1):110-8
references: 19362088
references: Digestion. 2013;87(2):121-31
references: 23406785
references: CA Cancer J Clin. 2012 Nov-Dec;62(6):394-9
references: 23070690
references: Liver Int. 2011 Nov;31(10):1494-504
references: 21955977
references: Gut. 2008 Nov;57(11):1592-6
references: 18669577
references: Nature. 2002 Jun 6;417(6889):664-7
references: 12050670
references: Cancer Res. 2007 Mar 15;67(6):2517-25
references: 17363569
references: Semin Oncol. 2012 Aug;39(4):410-33
references: 22846859
references: Hepatology. 2012 Feb;55(2):483-90
references: 21953299
references: Nature. 1998 Jan 22;391(6665):357-62
references: 9450748
references: Cancer Biomark. 2010;9(1-6):375-83
references: 22112485
references: Hepatology. 2009 Sep;50(3):661-2
references: 19714720
references: Curr Atheroscler Rep. 2009 May;11(3):206-13
references: 19361352
references: J Gastroenterol Hepatol. 2008 Oct;23(10):1541-8
references: 18422961
references: Toxicol Sci. 2008 May;103(1):4-13
references: 17890765
references: J Cell Mol Med. 2010 Aug;14(8):2037-44
references: 20597997
references: Cancer. 1988 Feb 15;61(4):769-74
references: 2448024
references: Hepatology. 1990 Dec;12(6):1420-32
references: 1701754
references: J Cancer Res Clin Oncol. 2004 Sep;130(9):497-513
references: 15205947
references: Br J Cancer. 2010 Sep 7;103(6):861-9
references: 20823889
references: N Engl J Med. 2009 Oct 8;361(15):1437-47
references: 19812400
references: J Hepatol. 2006 Oct;45(4):529-38
references: 16879891
references: N Engl J Med. 1984 May 31;310(22):1427-31
references: 6201741
references: Clin Chem. 2009 Sep;55(9):1656-64
references: 19628661
references: J Natl Compr Canc Netw. 2009 Apr;7(4):350-91
references: 19406039
references: Am J Gastroenterol. 2012 Jan;107(1):64-74
references: 21931376
references: Cancer Treat Rev. 2007 Aug;33(5):437-47
references: 17512669
references: Syst Rev. 2013 Jun 06;2:37
references: 23738605
references: Nat Med. 2003 Apr;9(4):416-23
references: 12640447
references: Lancet Oncol. 2012 Aug;13(8):817-26
references: 22738799
references: Int J Biol Markers. 2013 Sep 27;28(3):286-97
references: 23568769
references: Oncol Rep. 2011 Feb;25(2):433-41
references: 21165579
references: Oncologist. 2010;15 Suppl 4:5-13
references: 21115576
references: J Hepatol. 2009 May;50(5):948-57
references: 19303159
references: Hepatology. 2005 Nov;42(5):1208-36
references: 16250051
references: J Natl Cancer Inst. 2008 May 21;100(10):698-711
references: 18477802
references: Cell. 1979 Apr;16(4):885-93
references: 88265