title: Incidence of renal replacement therapy for diabetic nephropathy in the Netherlands: Dutch diabetes estimates (DUDE)-3.
abstract: OBJECTIVE
  Describe the incidence, prevalence and survival of patients needing renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetes mellitus (DM)-related glomerulosclerosis or nephropathy (diabetic nephropathy, DN) in the Netherlands.
  
  
  METHODS
  Using the national registry for RRT (RENINE-registry), data of all Dutch individuals initiating RRT for ESRD and having DN as primary diagnosis in the period 2000-2012 were obtained.
  
  
  METHODS
  Observational study in the Netherlands.
  
  
  METHODS
  Patients with ESRD needing RRT for DN.
  
  
  METHODS
  Age and gender adjusted incidence and prevalence of RRT for DN in the period 2000-2012. In addition, trends in time and patient's survival were examined.
  
  
  RESULTS
  The prevalence of DM in the general population increased from approximately 466 000 in 2000 to 815 000 in 2011. The number of individuals who started RRT with DN as primary diagnosis was 17.4 per million population (pmp) in 2000 and 19.1 pmp in 2012, with an annual percentage change (APC) of 0.8% (95% CI -0.4 to 2.0). For RRT due to type 1 DN, the incidence decreased from 7.3 to 3.5 pmp (APC -4.8%, 95% CI -6.5 to -3.1) while it increased for type 2 DN from 10.1 to 15.6 pmp (APC 3.1%, 95% CI 1.3 to 4.8). After 2009, the prevalence of RRT for DN remained stable (APC 1.0%, 95% CI -0.4 to 2.5). Compared to the period 2000-2004, patients initiating RRT and dialysis in 2005-2009 had better survival, HRs 0.8 (95% CI 0.7 to 0.8) and 0.8 (95% CI 0.7 to 0.9), respectively, while survival after kidney transplantation remained stable, HR 0.8, 95% CI 0.5 to 1.1).
  
  
  CONCLUSIONS
  Over the last decade, the incidence of RRT for DN was stable, with a decrease in RRT due to type 1 DN and an increase due to type 2 DN, while survival increased.
authors: Diabetes Centre, Isala, Zwolle, The Netherlands.
authors: Peter R
authors: PR
authors: van Dijk
authors: Department of Medical Informatics, Academic Medical Center, University of Amsterdam, ERA-EDTA Registry, Amsterdam, The Netherlands.
authors: Anneke
authors: A
authors: Kramer
authors: Diabetes Centre, Isala, Zwolle, The Netherlands Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
authors: Susan J J
authors: SJ
authors: Logtenberg
authors: Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands RENINE Registry, Leiden, The Netherlands.
authors: Andries J
authors: AJ
authors: Hoitsma
authors: Diabetes Centre, Isala, Zwolle, The Netherlands Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
authors: Nanne
authors: N
authors: Kleefstra
authors: Department of Medical Informatics, Academic Medical Center, University of Amsterdam, ERA-EDTA Registry, Amsterdam, The Netherlands.
authors: Kitty J
authors: KJ
authors: Jager
authors: Diabetes Centre, Isala, Zwolle, The Netherlands Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands Department of Internal Medicine, Isala, Zwolle, The Netherlands.
authors: Henk J G
authors: HJ
authors: Bilo
mesh_terms: D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012042:Registries; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data*; D016019:Survival Analysis
keywords: DIABETES & ENDOCRINOLOGY; SOCIAL MEDICINE
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