title: Cardiotoxicity due to chemotherapy: role of cardiac imaging.
abstract: The identification of patients at risk of cardiac toxicity (cardiotoxicity) from cancer therapy is challenging. There is an increasing focus on early detection of cardiotoxicity such that interventions can be instituted to prevent advanced heart failure. Clinical risk prediction tools are limited and clinical symptoms are not specific. Direct assessment of myocardial function before and during cancer treatment using cardiac imaging appears to be an objective method to identify patients at risk. Although, multiple imaging modalities and measures of cardiac function are available, the best modality or the optimal measure of function is unknown. Measurement of left ventricular ejection fraction is most commonly used; however, growing literature suggests that it is inadequate for the detection of early cardiac injury. Other measures include left ventricular diastolic function, myocardial deformation, and myocardial tissue characterization. This review will provide an overview of the clinically available measures for the assessment of cardiotoxicity.
authors: Division of Cardiology, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, Canada, M5G 2C4.
authors: Frédéric
authors: F
authors: Poulin
authors: Paaladinesh
authors: P
authors: Thavendiranathan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D057791:Cardiac Imaging Techniques / Q000379:methods*; D066126:Cardiotoxicity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013318:Stroke Volume / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents
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