title: Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep.
abstract: The aim of this study was to analyse the osseointegrative potential of phosphoserine-tethered dendrons when applied as surface functionalisation molecules on titanium implants in a sheep model after 2 and 8 weeks of implantation. Uncoated and dendron-coated implants were implanted in six sheep. Sandblasted and etched (SE) or porous additive manufactured (AM) implants with and without additional dendron functionalisation (SE-PSD; AM-PSD) were placed in the pelvic bone. Three implants per group were examined histologically and six implants were tested biomechanically. After 2 and 8 weeks the bone-to-implant contact (BIC) total values of SE implants (43.7±12.2; 53.3±9.0%) and SE-PSD (46.7±4.5; 61.7±4.9%) as well as AM implants (20.49±5.1; 43.9±9.7%) and AM-PSD implants (19.7±3.5; 48.3±15.6%) showed no statistically significant differences. For SE-PSD and AM-PSD a separate analysis of only the cancellous BIC demonstrated a statistically significant difference after 2 and 8 weeks. Biomechanical findings proved the overall increased stability of the porous implants after 8 weeks. Overall, the great effect of implant macro design on osseointegration was further supported by additional phosphoserine-tethered dendrons for SE and AM implants.
authors: Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty ZH, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland, stefan.stubinger@gmail.com.
authors: Stefan
authors: S
authors: Stübinger
authors: Katja
authors: K
authors: Nuss
authors: Alexander
authors: A
authors: Bürki
authors: Isabel
authors: I
authors: Mosch
authors: Miché
authors: M
authors: le Sidler
authors: Steve T
authors: ST
authors: Meikle
authors: Brigitte
authors: B
authors: von Rechenberg
authors: Matteo
authors: M
authors: Santin
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D050091:Dendrimers; D005260:Female; D005456:Fluorescent Dyes; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D016348:Osseointegration; D010768:Phosphoserine; D011107:Polylysine; D019736:Prostheses and Implants; D034561:Sheep, Domestic; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium; D019415:Torque
chemical_list: D020099:Coated Materials, Biocompatible; D050091:Dendrimers; D005456:Fluorescent Dyes; D010768:Phosphoserine; D011107:Polylysine; D014025:Titanium
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