title: Extracorporeal hepatic resection and autotransplantation for primary gastrointestinal stromal tumor of the liver.
abstract: We report a case of primary gastrointestinal stromal tumor of the liver. A 60-year-old woman with a large mass in the liver was asymptomatic with no hepatic virus infection and negative tumor markers. Because the tumor was unresectable by conventional means, we used extracorporeal hepatic resection and autotransplantation (ECHRA) for operation. The pathology showed a gastrointestinal stromal tumor that was diagnosed based on positive immunostaining for c-kit and CD34. Mutation analysis revealed an acquired mutation in exon 11 of c-kit. As we know, this is the eighth case of a primary hepatic extragastrointestinal stromal tumor reported previously in English, and the first case of which that was treated with ECHRA.
authors: Department of Hepatopancreatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China.
authors: L
authors: L
authors: Mao
authors: Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China.
authors: J
authors: J
authors: Chen
authors: Department of Vascular Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China.
authors: Z
authors: Z
authors: Liu
authors: Department of Vascular Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China.
authors: C-J
authors: CJ
authors: Liu
authors: Department of Medical Imaging, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China.
authors: M
authors: M
authors: Tang
authors: Department of Hepatopancreatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Province, China. Electronic address: yudongqiu510@163.com.
authors: Y-D
authors: YD
authors: Qiu
mesh_terms: D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D014182:Transplantation, Autologous
chemical_list: D019009:Proto-Oncogene Proteins c-kit