title: On-label and off-label drug use in the treatment of endometriosis.
abstract: Endometriosis, characterized by the presence of endometrial glands and stroma in extrauterine locations, is a significant cause of pelvic pain and infertility, as well as a major health care burden. Although Food and Drug Administration (FDA)-approved treatments are available, the use of "off-label" medications for endometriosis is widespread. In this review, we provide an overview of the current FDA-approved treatments, followed by a detailed review of the major "off-label" treatments being used in the United States and worldwide, including efficacy, side effects, drug interactions, contraindications, and anomaly risks.
authors: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: alexander-quaas@ouhsc.edu.
authors: Alexander M
authors: AM
authors: Quaas
authors: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors: Elizabeth A
authors: EA
authors: Weedin
authors: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors: Karl R
authors: KR
authors: Hansen
mesh_terms: D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D004348:Drug Labeling; D011307:Drug Prescriptions; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000627:therapeutic use; D006801:Humans; D056687:Off-Label Use; D034445:Ovulation Inhibition / Q000187:drug effects; D011372:Progestins / Q000627:therapeutic use; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D003278:Contraceptives, Oral, Hormonal; D011372:Progestins; D007987:Gonadotropin-Releasing Hormone
keywords: Endometriosis; off-label treatment