title: Unilateral cryptorchidism induces morphological changes of testes and hyperplasia of Sertoli cells in a dog.
abstract: Cryptorchidism is one of the most common genital defects in dogs. This study investigated the effects of abdominal cryptorchidism on morphology, cell proliferation, and Sertoli cell condition in a dog with spontaneous unilateral cryptorchidism. Elective orchidectomy was performed on the abdominal right testis and the scrotal left testis. Significant reductions in numbers of spermatogonia, spermatocytes, and spermatids were observed in hematoxylin and eosin stained sections of the cryptorchid testis. The size of the epididymal duct was smaller than that of the control testis. Based on Ki67 immunohistochemistry, the proliferative activity of spermatogonia and spermatocytes was significantly decreased in the cryptorchid testis. However, proliferative activity was increased in the epididymal duct. Based on GATA-4 immunohistochemistry, Sertoli cells were relatively resistant to cryptorchidism, and the proliferative activity of Sertoli cells was markedly increased in the cryptorchid testis than in the control testis. These results suggest that spontaneous unilateral cryptorchidism causes morphological defects in spermatogonia and spermatocytes in the testis and changes the size of the efferent ductule of the epididymis. In addition, spontaneous unilateral cryptorchidism increases proliferative activity of Sertoli cells, which may be a predisposing factor for Sertoli cell cancer in cryptorchid testes.
authors: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: Joon Ho
authors: JH
authors: Moon
authors: Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: Dae Young
authors: DY
authors: Yoo
authors: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: Young Kwang
authors: YK
authors: Jo
authors: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: Geon A
authors: GA
authors: Kim
authors: Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: Hyo Young
authors: HY
authors: Jung
authors: Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea.
authors: Jung Hoon
authors: JH
authors: Choi
authors: Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
authors: In Koo
authors: IK
authors: Hwang
authors: Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, Korea. ; BK21 PLUS Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea. ; Institute of Green Bio Science & Technology, Seoul National University, Pyeong Chang, Kangwon-do, Korea. ; Emergence Center for Food-Medicine Personalized Therapy System, Advanced Institutes of Convergence Technology, Seoul National University, Gyeonggi-do, Korea.
authors: Goo
authors: G
authors: Jang
keywords: Dog; efferent ductule; seminiferous tubule; sertoli cells; unilateral cryptorchidism
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