title: Controllable self-assembly of mesoporous hydroxyapatite.
abstract: In this paper, mesoporous hydroxyapatite (HAp) of controllable pore size was tailored with the template of a biodegradable mono-alkyl phosphate (MAP) via a simple route by hydrothermal treatment. A serial study of the various experimental parameters on pore size of HAp was investigated. The additive amount of MAP and hydrothermal temperature were important factors for the pore structure and pore size. Powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen adsorption-desorption (BET, BJH) were used to characterize the structure and composition of the HAp samples. Both XRD and BJH results indicated that regular mesoporous HAp nanoparticles (with a mean pore size of 3.5nm) were successfully produced. As shown in transmission electron microscopy (TEM), orderly uniform pore structure appeared in the HAp particles. Because of the special structure of the MAP and the interaction between ionized MAP and other ions in solution, the product presents uniform mesoporous structure with well-defined pore size.
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China. Electronic address: ibptcjd@fzu.edu.cn.
authors: Jingdi
authors: J
authors: Chen
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.
authors: Zihao
authors: Z
authors: Wang
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.
authors: Zhenliang
authors: Z
authors: Wen
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.
authors: Shen
authors: S
authors: Yang
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China.
authors: Jianhua
authors: J
authors: Wang
authors: Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, China; Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China. Electronic address: zhangqiq@126.com.
authors: Qiqing
authors: Q
authors: Zhang
mesh_terms: D017886:Durapatite / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010710:Phosphates / Q000494:pharmacology; D016062:Porosity; D053838:Scattering, Small Angle; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D010710:Phosphates; D017886:Durapatite
keywords: Hydrothermal conditions; Mesoporous hydroxyapatite; Mono-alkyl phosphate (MAP); Template