title: The price they paid.
abstract: BACKGROUND
  Several individuals integral to the development of evidence-based medicine endured hardship for their efforts and beliefs.
  
  
  METHODS
  We present the history of three individuals who were integral to the formation of evidence-based medicine. All three individuals suffered as a result of resistance to change from colleagues as well as from within the profession.
  
  
  CONCLUSIONS
  Individual and professional collegiality in the face of change should be maintained. The efforts of our predecessors are honored and provide us with inspiration.
authors: Department of Medicine, Reading Hospital, Reading, PA, USA; eugene.york@readinghealth.org.
authors: Eugene P
authors: EP
authors: York
authors: Department of Medicine, Reading Hospital, Reading, PA, USA.
authors: Tara
authors: T
authors: Brown
keywords: evidence-based medicine; medical history
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