title: Quantitative analysis linking inner hair cell voltage changes and postsynaptic conductance change: a modelling study.
abstract: This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to estimate the inner hair cell potential change in response to airborne sound. A generic and tunable topology of the mammalian synaptic ribbon is generated and the voltage dependence of its substructures is used to calculate discrete and probabilistic neurotransmitter vesicle release. Results suggest an almost linear relationship between increasing sound level (in dB SPL) and the postsynaptic conductance for frequencies considered too high for neurons to phase lock with (i.e., a few kHz). Furthermore coordinated vesicle release is shown for up to 300-400 Hz and a mechanism of phase shifting the subharmonic content of a stimulating signal is suggested. Model outputs suggest that strong onset response and highly synchronised multivesicular release rely on compound fusion of ribbon tethered vesicles.
authors: Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors: Andreas N
authors: 0000-0002-0586-5324
authors: AN
authors: Prokopiou
authors: Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors: Emm M
authors: EM
authors: Drakakis
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D055724:Electrophysiological Phenomena; D006199:Hair Cells, Auditory, Inner / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating; D008322:Mammals / Q000502:physiology; D008954:Models, Biological; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D002118:Calcium
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