title: SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology.
abstract: Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable of generating a Boolean function play critically important roles in synthetic biology. Basic genetic logic gates have been designed to combine biological science with digital logic. SynBioLGDB (http://bioinformatics.ac.cn/synbiolgdb/) aims to provide the synthetic biology community with a useful resource for efficient browsing and visualization of genetic logic gates. The current version of SynBioLGDB documents more than 189 genetic logic gates with experimental evidence involving 80 AND gates and 16 NOR gates, etc. in three species (Human, Escherichia coli and Bacillus clausii). SynBioLGDB provides a user-friendly interface through which conveniently to query and browse detailed information about these genetic logic gates. SynBioLGDB will enable more comprehensive understanding of the connection of genetic logic gates to execute complex cellular functions in living cells.
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Liqiang
authors: L
authors: Wang
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Kun
authors: K
authors: Qian
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Yan
authors: Y
authors: Huang
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Nana
authors: N
authors: Jin
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Hongyan
authors: H
authors: Lai
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Ting
authors: T
authors: Zhang
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Chunhua
authors: C
authors: Li
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Chunrui
authors: C
authors: Zhang
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Xiaoman
authors: X
authors: Bi
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Deng
authors: D
authors: Wu
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Changliang
authors: C
authors: Wang
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Hao
authors: H
authors: Wu
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Puwen
authors: P
authors: Tan
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Jianping
authors: J
authors: Lu
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Liqun
authors: L
authors: Chen
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Kongning
authors: K
authors: Li
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Xia
authors: X
authors: Li
authors: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors: Dong
authors: D
authors: Wang
mesh_terms: D030541:Databases, Genetic; D023281:Genomics / Q000379:methods*; D006801:Humans; D020407:Internet; D012984:Software; D058615:Synthetic Biology / Q000379:methods*
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