title: Pd(II)-catalyzed allylic C-H amination for the preparation of 1,2- and 1,3-cyclic ureas.
abstract: A general synthesis of 1,2- and 1,3-cyclic ureas is accomplished by intramolecular allylic C-H amination employing Pd(TFA)2/bis-sulfoxide as a catalyst. By careful modification of substrates and catalyst, a variety of 1,2-cyclic ureas are accessible from not previously employed terminal olefins substituted in allylic or vinylic positions. Furthermore, MS4A is found to be an effective additive for the synthesis of 1,3-cyclic ureas in good yields and excellent diastereoselectivities.
authors: Faculty of Pharmacy, Meijo University , 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors: Yasuhiro
authors: Y
authors: Nishikawa
authors: Seikou
authors: S
authors: Kimura
authors: Yuri
authors: Y
authors: Kato
authors: Natsuka
authors: N
authors: Yamazaki
authors: Osamu
authors: O
authors: Hara
mesh_terms: D000586:Amination; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010165:Palladium; D014508:Urea