title: Nylon-3 polymers active against drug-resistant Candida albicans biofilms.
abstract: Candida albicans is the most common fungal pathogen in humans, and most diseases produced by C. albicans are associated with biofilms. We previously developed nylon-3 polymers with potent activity against planktonic C. albicans and excellent C. albicans versus mammalian cell selectivity. Here we show that these nylon-3 polymers have strong and selective activity against drug-resistant C. albicans in biofilms, as manifested by inhibition of biofilm formation and by killing of C. albicans in mature biofilms. The best nylon-3 polymer (poly-βNM) is superior to the antifungal drug fluconazole for all three strains examined. This polymer is slightly less effective than amphotericin B (AmpB) for two strains, but the polymer is superior against an AmpB-resistant strain.
authors: Department of Chemistry, ‡Department of Medicine, and §Department of Biomedical Engineering, University of Wisconsin , Madison, Wisconsin 53706, United States.
authors: Runhui
authors: R
authors: Liu
authors: Xinyu
authors: X
authors: Chen
authors: Shaun P
authors: SP
authors: Falk
authors: Kristyn S
authors: KS
authors: Masters
authors: Bernard
authors: B
authors: Weisblum
authors: Samuel H
authors: SH
authors: Gellman
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D011108:Polymers
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