title: Correlation of 2 hour, 4 hour, 8 hour and 12 hour urine protein with 24 hour urinary protein in preeclampsia.
abstract: OBJECTIVE
  To find shortest and reliable time period of urine collection for determination of proteinuria.
  
  
  METHODS
  It is a prospective study carried out on 125 pregnant women with preeclampsia after 20 weeks of gestation having urine albumin >1 using dipstick test. Urine was collected in five different time intervals in colors labeled containers with the assistance of nursing staff; the total collection time was 24 hours. Total urine protein of two-hour, four-hour, eight-hour, 12-hour and 24-hour urine was measured and compared with 24-hour collection. Data was analyzed using the Pearson correlation coefficient.
  
  
  RESULTS
  There was significant correlation (p value < 0.01) in two, four, eight and 12-hour urine protein with 24-urine protein, with correlation coefficient of 0.97, 0.97, 0.96 and 0.97, respectively. When a cut off value of 25 mg, 50 mg. 100 mg, and 150 mg for urine protein were used for 2-hour, 4-hours, 8-hour and 12-hour urine collection, a sensitivity of 92.45%, 95.28%, 91.51%, and 96.23% and a specificity of 68.42%, 94.74%, 84.21% and 84.21% were obtained, respectively.
  
  
  CONCLUSIONS
  Two-hour urine proteins can be used for assessment of proteinuria in preeclampsia instead of gold standard 24-hour urine collection for early diagnosis and better patient compliance.
authors: Department of Obstetrics and Gynecology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Savita
authors: S
authors: Rani Singhal
authors: Department of Biochemistry, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Veena
authors: V
authors: Ghalaut
authors: Department of Obstetrics and Gynecology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Shashi
authors: S
authors: Lata
authors: Department of Biochemistry, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Himanshu
authors: H
authors: Madaan
authors: Department of Obstetrics and Gynecology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Veenu
authors: V
authors: Kadian
authors: Department of Biochemistry, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Ashuma
authors: A
authors: Sachdeva
keywords: Pre Eclampsia; Timed Collection; Urinary Protein
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