title: The scientific foundation, rationale and argument for a nonfrequentist Bayesian analysis in clinical trials in coronary artery disease.
abstract: Randomised control trials (RCT) are considered the gold standard for the strength of evidence used in formulation of guidelines in the contemporary clinical practice. The analysis is based on the design of an experiment that analyses data collected in a future event space with no regard to past observations. It bases its conclusions on arbitrary values of significance that might not be clinically relevant or plausible. A Bayesian analysis looks at all the past evidence and observations to reach a conclusion and does not have the shortcomings of a RCT.
authors: Cardiac Surgery, Massachusetts General Hospital, Boston. Electronic address: suviteshluthra@yahoo.com.
authors: Suvitesh
authors: S
authors: Luthra
mesh_terms: D001499:Bayes Theorem; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*
keywords: Bayesian analysis; Coronary artery disease; Frequentist analysis; Prior; Randomized control trials