title: Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats.
abstract: BACKGROUND
  Natural antioxidants can reduce oxidative damage caused by high-intensity resistance training (RT). We investigated the in vitro antioxidant potential of hydroethanolic extract (HEE) from Bowdichia virgilioides on muscular damage and oxidative stress in rats subjected to high-intensity RT.
  
  
  METHODS
  Thirty-two male Wistar rats were divided into four experimental groups: 1) control group (CG), oral administration (P.O.) of vehicle; 2) trained group (TG), vehicle-treated with RT; 3) B. virgilioides untrained group (BVG), treated with B. virgilioides HEE (200 mg/kg P.O.); and 4) trained B. virgilioides group (TBVG), treated with B. virgiliodes HEE (200 mg/kg P.O.). All animals were habituated to the training apparatus for 1 week. CT and TBVG animals were subjected to the training protocol, which consisted of three sets of 10 repetitions with 75% of the load established using the one-repetition maximum, for four weeks. CG and BVG animals were manipulated and fixed to the apparatus three times a week with no load. Treatment with B. virgilioides HEE or vehicle treatment was initiated after 25 days of RT (5 days; one dose per day). At the end of the experiments, plasmatic and gastrocnemius samples from all groups were obtained for the assessment of lipid peroxidation and creatine kinase activity.
  
  
  RESULTS
  Compared to TG rats, TBVG rats showed decreases in plasma and gastrocnemius tissue lipid peroxidation by 55.68% (p <0.0001) and 66.61% (p <0.0012), respectively. Further, compared to TG rats TBVG rats showed decreases in plasma and gastrocnemius tissue oxidative stress by 62.83% (p <0.0005) and 54.97% (p <0.0197), respectively.
  
  
  CONCLUSIONS
  B. virgilioides HEE treatment reduced markers of oxidative stress caused by high-intensity RT. Further, HEE treatment during training significantly reduced the markers of tissue damage.
authors: Postgraduate program in Physical Education, Department of Physical Education, Federal University of Sergipe, São Cristóvão, SE 49100-000 Brazil ; Federal University of Sergipe, Cidade Universitária Prof. José Aloísio de Campos, Department of Morphology, Av. Marechal Rondon s/n, Jardim Rosa Elze, São Cristóvão, Sergipe 49100-000 Brazil.
authors: Jymmys Lopes
authors: JL
authors: Dos Santos
authors: Federal University of Sergipe, Cidade Universitária Prof. José Aloísio de Campos, Department of Morphology, Av. Marechal Rondon s/n, Jardim Rosa Elze, São Cristóvão, Sergipe 49100-000 Brazil.
authors: Rafaela Eugênia Arce
authors: RE
authors: Dantas
authors: Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000 Brazil.
authors: Clésio Andrade
authors: CA
authors: Lima
authors: Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000 Brazil.
authors: Silvan Silva
authors: SS
authors: de Araújo
authors: Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000 Brazil.
authors: Elis Cristiane Valença
authors: EC
authors: de Almeida
authors: Federal University of Sergipe, Cidade Universitária Prof. José Aloísio de Campos, Department of Morphology, Av. Marechal Rondon s/n, Jardim Rosa Elze, São Cristóvão, Sergipe 49100-000 Brazil.
authors: Anderson Carlos
authors: AC
authors: Marçal
authors: Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000 Brazil.
authors: Charles Dos Santos
authors: Cdos S
authors: Estevam
keywords: Hydroethanolic extract; Oxidative stress; Physical exercise
references: Int J Sport Nutr Exerc Metab. 2012 Dec;22(6):486-96
references: 22805286
references: Med Sci Sports Exerc. 2005 Sep;37(9):1622-6
references: 16177617
references: Oxid Med Cell Longev. 2008 Oct-Dec;1(1):15-24
references: 19794904
references: Methods Enzymol. 1994;233:357-63
references: 8015470
references: Vet Clin Pathol. 2001;30(4):214-218
references: 12024305
references: Am J Phys Med. 1979 Jun;58(3):115-30
references: 453338
references: J Agric Food Chem. 2008 May 14;56(9):3341-9
references: 18386928
references: Clin Nutr. 2006 Jun;25(3):444-53
references: 16426710
references: Nat Prod Res. 2013;27(16):1479-83
references: 22963455
references: Exerc Sport Sci Rev. 2005 Apr;33(2):63-8
references: 15821426
references: Med Sci Sports Exerc. 2009 Jul;41(7):1510-30
references: 19516148
references: Public Health Rep. 1985 Mar-Apr;100(2):126-31
references: 3920711
references: Amino Acids. 2010 Jun;39(1):219-32
references: 19967420
references: Med Sci Sports Exerc. 2005 Jan;37(1):63-71
references: 15632670
references: Proc Soc Exp Biol Med. 1999 Dec;222(3):283-92
references: 10601887
references: Redox Biol. 2014;2:65-72
references: 25460722
references: Sports Med. 2007;37(10):827-36
references: 17887809
references: Free Radic Biol Med. 2001 Aug 1;31(3):331-5
references: 11461770
references: Cell Biol Int. 2000;24(5):263-72
references: 10805959
references: Clin Exp Pharmacol Physiol. 2005 Apr;32(4):249-54
references: 15810987
references: Free Radic Biol Med. 1996;20(7):933-56
references: 8743980
references: Parkinsonism Relat Disord. 2009 Dec;15(10):752-7
references: 19497777
references: Fitoterapia. 2011 Jun;82(4):513-23
references: 21277359
references: Free Radic Biol Med. 2011 Jul 15;51(2):257-81
references: 21554949
references: J Appl Physiol (1985). 2000 Dec;89(6):2325-32
references: 11090586
references: Am J Phys Med Rehabil. 2002 Nov;81(11 Suppl):S52-69
references: 12409811
references: Nutrition. 2008 May;24(5):433-42
references: 18337059
references: Free Radic Biol Med. 2007 Sep 15;43(6):901-10
references: 17697935
references: Nutrition. 2013 Sep;29(9):1127-32
references: 23800565
references: Phytother Res. 2013 May;27(5):672-7
references: 22745005
references: Free Radic Biol Med. 1996;20(3):331-42
references: 8720903
references: Eur J Appl Physiol. 2005 Oct;95(4):290-7
references: 16096840
references: Phys Ther. 2001 Feb;81(2):819-27
references: 11175679
references: Lipids Health Dis. 2004 Jun 22;3:14
references: 15212697
references: Clin Sci (Lond). 2003 Jan;104(1):69-77
references: 12519089
references: Pharmacogn Rev. 2010 Jul;4(8):118-26
references: 22228951
references: Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1037-42
references: 24119988
references: Arch Phys Med Rehabil. 2013 Aug;94(8):1458-72
references: 23473702
references: J Sci Med Sport. 2005 Sep;8(3):264-73
references: 16248467
references: Molecules. 2010 Nov 24;15(12):8534-42
references: 21107308
references: J Invest Dermatol. 1999 Sep;113(3):335-9
references: 10469330
references: J Int Soc Sports Nutr. 2013 Dec 10;10(1):54
references: 24325803
references: Physiol Behav. 2005 Jan 31;84(1):1-7
references: 15642600
references: Food Chem Toxicol. 2011 Sep;49(9):2222-8
references: 21712063
references: Free Radic Biol Med. 2004 Apr 15;36(8):966-75
references: 15059637
references: Molecules. 2013 Jun 10;18(6):6852-65
references: 23752469
references: Med Sci Sports Exerc. 1992 Aug;24(8):881-6
references: 1406173
references: Nutr Res. 2013 Oct;33(10 ):868-75
references: 24074745
references: Molecules. 2010 Oct 21;15(10):7313-52
references: 20966876
references: Res Commun Mol Pathol Pharmacol. 1997 Feb;95(2):179-89
references: 9090754
references: Int J Biochem Cell Biol. 2007;39(1):44-84
references: 16978905
references: Med Sci Sports Exerc. 2003 Nov;35(11):1859-65
references: 14600551