title: Effect of low-level laser on healing of temporomandibular joint osteoarthritis in rats.
abstract: OBJECTIVE
  Temporomandibular disorders (TMD) are clinical conditions characterized by pain and sounds of the temporomandibular joint (TMJ). This study was designed to assess the effect of low-level laser therapy (LLLT) on healing of osteoarthritis in rats with TMD.
  
  
  METHODS
  Thirty-two male Wistar rats (250-200 g) were housed in standard plastic cages. After injection of Complete Freund's adjuvant into the TMJ, rats were randomly divided into two groups of 16 (case and control) and anesthetized; then osteoarthritis was induced via intraarticular injection of 50 µl of Complete Freund's adjuvant; into the bilateral TMJs. In the case group, LLLT was done transcutaneously for 10 minutes daily, starting the day after the confirmation of osteoarthritis. Exposure was performed for 10 minutes at the right side of the TMJ with 880 nm low-level laser with 100 mW power and a probe diameter of 0.8 mm. Control rats were not treated with laser.
  
  
  RESULTS
  After three days of treatment the grade of cartilage defects, number of inflammatory cells, angiogenesis, number of cell layers and arthritis in rats in the case group were not significantly different compared with controls (P>0.05). After seven days, the grade of cartilage defects, number of inflammatory cells, number of cell layers, and arthritis in the case group improved compared to controls (P<0.05); angiogenesis in both groups was similar.
  
  
  CONCLUSIONS
  Treatment of TMD with LLLT after 7 days of irradiation with a wavelength of 880 nm was associated with a greater improvement compared to the control group.
authors: Assistant Professor, Department of Oral Surgery, Dental School of Rafsanjan University, Rafsanjan, Iran.
authors: Ali
authors: A
authors: Peimani
authors: Assistant Professor, Department of Oral Medicine, Dental School of Rafsanjan University, Rafsanjan, Iran.
authors: Farimah
authors: F
authors: Sardary
keywords: TMJ disorders; laser therapy; osteoarthritis
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