title: Update on linezolid in vitro activity through the Zyvox Annual Appraisal of Potency and Spectrum Program, 2013.
abstract: Linezolid showed MIC50s and MIC90s of 1 μg/ml (for both) against Staphylococcus aureus. Two S. aureus strains exhibited higher MICs (4 to 8 μg/ml) caused by cfr and/or target site mutations, including the first detection of cfr in Poland. Linezolid (MIC50 and MIC90, 0.5 and 1 μg/ml) had potent MICs against coagulase-negative staphylococci (CoNS). Four CoNS had MICs of 16 to 128 μg/ml due to alterations in 23S rRNA and/or L3/L4. Linezolid inhibited all enterococci and streptococci at ≤2 μg/ml, except for one Enterococcus faecium strain (MIC, 8 μg/ml; G2576T [Escherichia coli numbering] mutation).
authors: JMI Laboratories, North Liberty, Iowa, USA rodrigo-mendes@jmilabs.com.
authors: Rodrigo E
authors: RE
authors: Mendes
authors: Pfizer Inc., Collegeville, Pennsylvania, USA.
authors: Patricia A
authors: PA
authors: Hogan
authors: JMI Laboratories, North Liberty, Iowa, USA.
authors: Jennifer M
authors: JM
authors: Streit
authors: JMI Laboratories, North Liberty, Iowa, USA.
authors: Ronald N
authors: RN
authors: Jones
authors: JMI Laboratories, North Liberty, Iowa, USA.
authors: Robert K
authors: RK
authors: Flamm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology; D016984:Enterococcus faecium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D000069349:Linezolid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011358:Product Surveillance, Postmarketing; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid
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