title: Functional correlates of t-Tau, p-Tau and Aβ₁₋₄₂ amyloid cerebrospinal fluid levels in Alzheimer's disease: a ¹⁸F-FDG PET/CT study.
abstract: OBJECTIVE
  The aim of the study was to investigate the relationships between cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and amyloid-β (Aβ₁₋₄₂) amyloid peptide and fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) brain distribution in a group of patients with Alzheimer's disease.
  
  
  METHODS
  The study included 81 newly diagnosed Alzheimer's disease patients according to the NINCDS-ADRDA criteria. The mean (±SD) age of the patients was 70 (±6) years; 44 were male and 37 were female. All patients underwent a CSF assay and MRI before ¹⁸F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8).
  
  
  RESULTS
  Increased t-Tau CSF levels were related to reduced glucose consumption in a wide portion of the right frontal lobe [Brodmann area (BA 47)] and limbic lobe bilaterally (BA 31,32), whereas no areas of increased ¹⁸F-FDG uptake related to t-Tau levels were detected. Elevated p-Tau concentrations in CSF were related to increased glucose consumption in both the right and the left limbic lobe and in the left frontal lobe (BA 32 and 8). We did not find any specific cortical area of reduced glucose consumption being related to low levels of Aβ₁₋₄₂ in CSF, whereas a spawn of ¹⁸F-FDG uptake was detectable in BA 18,19 and in the right cerebellum.
  
  
  CONCLUSIONS
  The results of our study suggest that reduced Aβ₁₋₄₂ concentrations in CSF are related to a wide cortical dysfunction, whereas t-Tau and p-Tau are related to more selective cortical metabolic patterns that mainly involve the cingulate cortex.
authors: Departments of aBiomedicine and Prevention bNeurosciences, University Tor Vergata, Rome cIRCCS Neuromed, Pozzilli, Italy.
authors: Agostino
authors: A
authors: Chiaravalloti
authors: Alessandro
authors: A
authors: Martorana
authors: Giacomo
authors: G
authors: Koch
authors: Sofia
authors: S
authors: Toniolo
authors: Daniele
authors: D
authors: di Biagio
authors: Barbara
authors: B
authors: di Pietro
authors: Orazio
authors: O
authors: Schillaci
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016875:tau Proteins / Q000134:cerebrospinal fluid* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D019788:Fluorodeoxyglucose F18