title: Metabolomics in the developmental origins of obesity and its cardiometabolic consequences.
abstract: In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.
authors: 1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
authors: M F
authors: MF
authors: Hivert
authors: 1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
authors: W
authors: W
authors: Perng
authors: 3Metabolon Inc.,West Sacramento,CA,USA.
authors: S M
authors: SM
authors: Watkins
authors: 4Nutrition and Metabolism Center,Duke University of Medicine,Durham,NC,USA.
authors: C S
authors: CS
authors: Newgard
authors: 5The Irish Center for Fetal and Neonatal Translational Research,University College Cork,Co. Cork,USA.
authors: L C
authors: LC
authors: Kenny
authors: 6Departments of Neurosurgery,Brigham & Women's Hospital and Harvard Medical School,Boston,MA,USA.
authors: B S
authors: BS
authors: Kristal
authors: 7Research Division,Joslin Diabetes Center,Boston,MA,USA.
authors: M E
authors: ME
authors: Patti
authors: 7Research Division,Joslin Diabetes Center,Boston,MA,USA.
authors: E
authors: E
authors: Isganaitis
authors: 8Department of Medicine,Channing Division of Network Medicine and Division of Pulmonary and Critical Care,Brigham and Women's Hospital,Boston,MA,USA.
authors: D L
authors: DL
authors: DeMeo
authors: 1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
authors: E
authors: E
authors: Oken
authors: 1Obesity Prevention Program,Department of Population Medicine,Harvard Medical School and Harvard Pilgrim Health Care Institute,Boston,MA,USA.
authors: M W
authors: MW
authors: Gillman
mesh_terms: D000818:Animals; D006801:Humans; D055432:Metabolomics; D009765:Obesity / Q000209:etiology* / Q000378:metabolism
keywords: obesity
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