title: Correlation between osteocalcin-positive endothelial progenitor cells and spotty calcification in patients with coronary artery disease.
abstract: Immature endothelial progenitor cells (EPC) carrying osteocalcin (OCN) might mediate vascUlar calcification in coronary artery disease (CAD). Spotty calcification within atherosclerotic plaque is associated with cardiovascular events. The aim of the present study was to assess the correlation between immature EPC levels and spotty calcification in CAD patients. In the 224 CAD patients studied, 76 had acute myocardial infarction (AMI), 102 had unstable angina pectoris (UAP), and 46 had stable angina pectoris (SAP). The levels of OCN-positive (OCN+) EPC were analysed by flow cytometry. The status of spotty calcification was determined by cardiac computed tomography angiography. OCN+ EPC and calcium deposits were significantly increased in acute coronary artery syndrome (ACS) when compared with those in SAP patients. Positive correlation was also revealed between the number of OCN+ EPC and the frequency of spotty calcification and levels of serum high-sensitivity C-reactive protein (hs-CRP) and serum alkaline phosphatase in AMI and UAP patients. In summary, the number of OCN+ EPC is positively related to the frequency of spotty calcification in ACS patients. Serum hs-CRP and serum alkaline levels are thought to contribute to the elevation of OCN+ EPC.
authors: Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: He
authors: H
authors: Zhang
authors: Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: Li-jun
authors: LJ
authors: Wang
authors: Department of CT and MR, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: Dong-lei
authors: DL
authors: Si
authors: Department of Pharmacology, Hebei Medical University, Shijiazhuang, China.
authors: Chuan
authors: C
authors: Wang
authors: Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
authors: Jing-ci
authors: JC
authors: Yang
authors: Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: Ping
authors: P
authors: Jiang
authors: Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: Chao
authors: C
authors: Du
authors: Department of Cardiology, The Third Hospital of Shijiazhuang City, Shijiazhuang, China.
authors: Jian-jun
authors: JJ
authors: Wang
mesh_terms: D000071916:AC133 Antigen; D000469:Alkaline Phosphatase / Q000097:blood; D015703:Antigens, CD / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002114:Calcinosis / Q000150:complications*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D066026:Endothelial Progenitor Cells / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D010455:Peptides; D015675:Osteocalcin; D002097:C-Reactive Protein; D040301:Vascular Endothelial Growth Factor Receptor-2; D000469:Alkaline Phosphatase
keywords: atherosclerosis; calcification; endothelial progenitor cells; osteoblast; osteocalcin