title: Diagnostic significance of reduced IgA in children.
abstract: BACKGROUND
  The finding of reduced value of immunoglobulin A (IgA) in children is frequent in daily medical practice. It is important to correctly interpret the findings as adequate further diagnostic evaluation of the patient in order to make the determination on the significance of such findings. In children younger than 4 years always consider the transient impairment of immunoglobulins, maturation of child and his immune system can lead to an improvement in the clinical picture. In older children decreased IgA may lead to serious illnesses that need to be recognize and acknowledge through the appropriate diagnostic methods.
  
  
  METHODS
  Research was realized at the University Clinical Center Tuzla. Children with suspected deficient immune response due to reduced values of IgA observed and, goes through further diagnostic evaluation at the Polyclinic for Laboratory Medicine, Department of Immunology and Department of Microbiology, as well as the Clinic of Radiology. In the period of year 2013, there were a total of 91 patients with reduced values of IgA, age up to 13 years, of which 55 boys and 36 girls.
  
  
  RESULTS
  Our study followed 91 patients, for the year 2013, through their medical charts and made evaluation of diagnostic and screening tests. The significance of this paper is to draw attention to the importance of diagnostic approach to IgA deficient pediatric patient and relevance of knowledge of individual diagnostic methods as well as to the proper interpretation of the results thereof.
authors: Polyclinic for laboratory diagnostic. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Jasmina
authors: J
authors: Nurkic
authors: Polyclinic for laboratory diagnostic. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Fatima
authors: F
authors: Numanovic
authors: Clinic for Radiology. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Lejla
authors: L
authors: Arnautalic
authors: Polyclinic for laboratory diagnostic. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Nijaz
authors: N
authors: Tihic
authors: Clinic for Pulmonary Disease. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Dzenan
authors: D
authors: Halilovic
authors: Polyclinic for laboratory diagnostic. University Clinical Centre Tuzla, Bosnia and Herzegovina.
authors: Mahira
authors: M
authors: Jahic
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017098:IgA Deficiency / Q000175:diagnosis* / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index
chemical_list: D007070:Immunoglobulin A
keywords: IgA deficiency; children; diagnostic evaluation
references: Arch Pediatr Adolesc Med. 2000 Feb;154(2):190-4
references: 10665608
references: Infect Immun. 2002 Jan;70(1):11-8
references: 11748158
references: Clin Immunol. 2004 Apr;111(1):93-7
references: 15093556
references: Lancet. 1985 Apr 6;1(8432):778-81
references: 2858666
references: J Exp Med. 1990 Mar 1;171(3):597-613
references: 2137852
references: Biochem J. 1990 Oct 15;271(2):285-96
references: 2241915
references: Clin Exp Immunol. 2012 Apr;168(1):58-9
references: 22385238
references: Ann Allergy Asthma Immunol. 1996 Oct;77(4):333-6
references: 8885812
references: J Pathol. 2006 Jan;208(2):270-82
references: 16362985
references: Immunity. 2008 Jun;28(6):740-50
references: 18549797
references: J Clin Immunol. 2009 Jan;29(1):130-6
references: 18683032
references: Blood. 2009 Nov 5;114(19):4089-98
references: 19738033
references: J Clin Immunol. 2010 Jan;30(1):10-6
references: 20101521
references: Int Arch Allergy Immunol. 1992;99(1):16-27
references: 1483063