title: Genetically engineered mucin mouse models for inflammation and cancer.
abstract: Mucins are heavily O-glycosylated proteins primarily produced by glandular and ductal epithelial cells, either in membrane-tethered or secretory forms, for providing lubrication and protection from various exogenous and endogenous insults. However, recent studies have linked their aberrant overexpression with infection, inflammation, and cancer that underscores their importance in tissue homeostasis. In this review, we present current status of the existing mouse models that have been developed to gain insights into the functional role(s) of mucins under physiological and pathological conditions. Knockout mouse models for membrane-associated (Muc1 and Muc16) and secretory mucins (Muc2) have helped us to elucidate the role of mucins in providing effective and protective barrier functions against pathological threats, participation in disease progression, and improved our understanding of mucin interaction with biotic and abiotic environmental components. Emphasis is also given to available transgenic mouse models (MUC1 and MUC7), which has been exploited to understand the context-dependent regulation and therapeutic potential of human mucins during inflammation and cancer.
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Suhasini
authors: S
authors: Joshi
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Sushil
authors: S
authors: Kumar
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Sangeeta
authors: S
authors: Bafna
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Satyanarayana
authors: S
authors: Rachagani
authors: Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.|Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Kay-Uwe
authors: KU
authors: Wagner
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.|Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.|Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.
authors: Maneesh
authors: M
authors: Jain
authors: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA. sbatra@unmc.edu.|Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA. sbatra@unmc.edu.|Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA. sbatra@unmc.edu.|Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA. sbatra@unmc.edu.
authors: Surinder K
authors: SK
authors: Batra
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D004195:Disease Models, Animal; D018450:Disease Progression; D005818:Genetic Engineering; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D009077:Mucins / Q000235:genetics*; D009092:Mucous Membrane / Q000378:metabolism*; D009369:Neoplasms / Q000473:pathology*; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D009077:Mucins
keywords: Cancer; Knockout models; Mucins; Synteny; Transgenic mice models; Vaccines
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