title: Orchestrating high-throughput genomic analysis with Bioconductor.
abstract: Bioconductor is an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology. The project aims to enable interdisciplinary research, collaboration and rapid development of scientific software. Based on the statistical programming language R, Bioconductor comprises 934 interoperable packages contributed by a large, diverse community of scientists. Packages cover a range of bioinformatic and statistical applications. They undergo formal initial review and continuous automated testing. We present an overview for prospective users and contributors.
authors: European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Wolfgang
authors: 0000000204742218
authors: W
authors: Huber
authors: 1] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Vincent J
authors: VJ
authors: Carey
authors: Genentech, South San Francisco, California, USA.
authors: Robert
authors: R
authors: Gentleman
authors: European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Simon
authors: 0000000348681805
authors: S
authors: Anders
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Marc
authors: M
authors: Carlson
authors: Department of Medical Genetics, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors: Benilton S
authors: 0000000151225646
authors: BS
authors: Carvalho
authors: Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.
authors: Hector Corrada
authors: HC
authors: Bravo
authors: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors: Sean
authors: 0000000289916458
authors: S
authors: Davis
authors: Department of Biochemistry, University of Cambridge, Cambridge, UK.
authors: Laurent
authors: 0000000215202268
authors: L
authors: Gatto
authors: Institute for Integrative Genome Biology, University of California, Riverside, Riverside, California, USA.
authors: Thomas
authors: T
authors: Girke
authors: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Raphael
authors: R
authors: Gottardo
authors: Novartis Institutes for Biomedical Research, Basel, Switzerland.
authors: Florian
authors: F
authors: Hahne
authors: 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA.
authors: Kasper D
authors: KD
authors: Hansen
authors: 1] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors: Rafael A
authors: RA
authors: Irizarry
authors: Genentech, South San Francisco, California, USA.
authors: Michael
authors: M
authors: Lawrence
authors: 1] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors: Michael I
authors: 0000000184010545
authors: MI
authors: Love
authors: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
authors: James
authors: J
authors: MacDonald
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Valerie
authors: V
authors: Obenchain
authors: European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Andrzej K
authors: AK
authors: Oleś
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Hervé
authors: H
authors: Pagès
authors: European Molecular Biology Laboratory, Heidelberg, Germany.
authors: Alejandro
authors: A
authors: Reyes
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Paul
authors: P
authors: Shannon
authors: 1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. [2] Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia.
authors: Gordon K
authors: GK
authors: Smyth
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Dan
authors: D
authors: Tenenbaum
authors: School of Urban Public Health at Hunter College, City University of New York, New York, New York, USA.
authors: Levi
authors: L
authors: Waldron
authors: Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors: Martin
authors: 0000000258748148
authors: M
authors: Morgan
mesh_terms: D019295:Computational Biology; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods*; D011381:Programming Languages; D012984:Software; D014584:User-Computer Interface
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