title: Antimicrobial peptides of the genus Bacillus: a new era for antibiotics.
abstract: The rapid onset of resistance reduces the efficacy of most conventional antimicrobial drugs and is a general cause of concern for human well-being. Thus, there is great demand for a continuous supply of novel antibiotics to combat this problem. Bacteria-derived antimicrobial peptides (AMPs) have long been used as food preservatives; moreover, prior to the development of conventional antibiotics, these AMPs served as an efficient source of antibiotics. Recently, peptides produced by members of the genus Bacillus were shown to have a broad spectrum of antimicrobial activity against pathogenic microbes. Bacillus-derived AMPs can be synthesized both ribosomally and nonribosomally and can be classified according to peptide biosynthesis, structure, and molecular weight. The precise mechanism of action of these AMPs is not yet clear; however, one proposed mechanism is that these AMPs kill bacteria by forming channels in and (or) disrupting the bacterial cell wall. Bacillus-derived AMPs have potential in the pharmaceutical industry, as well as the food and agricultural sectors. Here, we focus on Bacillus-derived AMPs as a novel alternative approach to antibacterial drug development. We also provide an overview of the biosynthesis, mechanisms of action, applications, and effectiveness of different AMPs produced by members of the Bacillus genus, including several recently identified novel AMPs.
authors: a Department of Systems Biotechnology, Chung-Ang University, 72-1 Nae-Ri, Daeduk-Myun, Anseong-Si, Gyeonggi-Do 456-756, South Korea.
authors: Chandra Datta
authors: CD
authors: Sumi
authors: Byung Wook
authors: BW
authors: Yang
authors: In-Cheol
authors: IC
authors: Yeo
authors: Young Tae
authors: YT
authors: Hahm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D012270:Ribosomes / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D055666:Lipopeptides; D010455:Peptides
keywords: Bacillus species; antibiorésistance; antibiotic resistance; antibiotics; antibiotiques; antimicrobial peptides; espèces de Bacillus; peptides antimicrobiens