title: Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience.
abstract: BACKGROUND
  Eales' disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. tuberculosis) infection. This study is aimed at the detection of association of M. tuberculosis in patients with Eales' disease.
  
  
  METHODS
  A prospective case-control study was undertaken in 65 clinically diagnosed cases of Eales' disease. Patients with proliferative diabetic retinopathy, neo-vascular proliferation, macular oedema, premacular fibrosis and tractional retinal detachment were taken as controls. M. tuberculosis DNA was detected (MPT64 gene by polymerase chain reaction, PCR) in patients with Eales' disease. Clinical symptoms along with tuberculin skin test (TST) and erythrocyte sedimentation rate (ESR) were used as gold standard for comparing results of PCR.
  
  
  RESULTS
  PCR positivity was found in 12 (38.7%) patients with Eales' disease. The PCR positivity was significantly associated with the patients with high TST reading and high ESR values.
  
  
  CONCLUSIONS
  Patients with a high TST reading and ESR value and a positive PCR in vitreous samples have a high likelihood of having M. tuberculosis as an etiology.
authors: Department of Microbiology, ? All India Institute of Medical Sciences, New Delhi, India.
authors: U B
authors: UB
authors: Singh
authors: S
authors: S
authors: Mohapatra
authors: V K
authors: VK
authors: Wagh
authors: C
authors: C
authors: Porwal
authors: A
authors: A
authors: Kaushik
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D016022:Case-Control Studies; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D031300:Retinal Vasculitis / Q000175:diagnosis* / Q000382:microbiology*; D012307:Risk Factors; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology*; D055815:Young Adult