title: Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury.
abstract: Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
authors: Department of Orthopedics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.
authors: Zhi
authors: Z
authors: Li
authors: Department of Orthopedics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.
authors: Wei
authors: W
authors: Zhao
authors: Department of Obstetrics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.
authors: Wei
authors: W
authors: Liu
authors: Department of Obstetrics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.
authors: Ye
authors: Y
authors: Zhou
authors: Liaoning Province Wellcare Stem Cells Biotechnology Co., Ltd., Benxi, Liaoning Province, China.
authors: Jingqiao
authors: J
authors: Jia
authors: Department of Orthopedics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.
authors: Lifeng
authors: L
authors: Yang
keywords: motor function; nerve regeneration; nerve-like cells; neural regeneration; neural stem cells; placenta-derived mesenchymal stem cells; sensory function; spinal cord injury; stem cells
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