title: Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma.
authors: Anticancer Antibody Team, INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon, France Hospices Civils de Lyon, France ProfileXpert, Lyon, France lars-petter.jordheim@univ-lyon1.fr.
authors: Lars P
authors: LP
authors: Jordheim
authors: Institut Gustave Roussy, Villejuif, France.
authors: Vincent
authors: V
authors: Ribrag
authors: Hematology, Centre Léon Bérard, UMR 5239 CNRS, Lyon, France.
authors: Hervé
authors: H
authors: Ghesquieres
authors: GELA-RC, Hospices Civils de Lyon, Pierre Bénite, France.
authors: Sophie
authors: S
authors: Pallardy
authors: Hematology, Necker Hospital, Paris, France.
authors: Richard
authors: R
authors: Delarue
authors: Centre Henri Becquerel, Rouen, France.
authors: Hervé
authors: H
authors: Tilly
authors: Hematology, Hôpital Henri Mondor, Créteil, France.
authors: Corinne
authors: C
authors: Haioun
authors: Hematology, INSERM U918, Centre Henri Becquerel, Rouen, France.
authors: Fabrice
authors: F
authors: Jardin
authors: Hospices Civils de Lyon, France ProfileXpert, Lyon, France.
authors: Delphine
authors: D
authors: Demangel
authors: Hospices Civils de Lyon, Centre Hospitalier Universitaire Lyon-Sud, Hématologie, Université Lyon 1, UMR 5239 CNRS, France.
authors: Gilles A
authors: GA
authors: Salles
authors: Anticancer Antibody Team, INSERM U1052, CNRS UMR 5286, Cancer Research Center of Lyon, France Hospices Civils de Lyon, France ProfileXpert, Lyon, France Laboratory of Hematology, Hospices Civils de Lyon, Pierre-Bénite, France.
authors: Charles
authors: C
authors: Dumontet
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011379:Prognosis; D000069283:Rituximab; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D000429:Alcohol Oxidoreductases; C531129:CBR1 protein, human; D011241:Prednisone
keywords: ABCB1; CBR1; R-CHOP; SNP; non-Hodgkin lymphoma; toxicity
references: Drug Metab Dispos. 2009 May;37(5):1107-14
references: 19204081
references: Blood. 2009 Apr 2;113(14):3307-13
references: 18768784
references: Expert Opin Drug Metab Toxicol. 2011 Oct;7(10):1201-10
references: 21919804
references: Haematologica. 2007 Apr;92(4):478-85
references: 17488658
references: Blood. 2003 Dec 15;102(13):4284-9
references: 12920037
references: PLoS One. 2012;7(11):e48622
references: 23133646
references: Pharm Res. 2008 Jul;25(7):1730-4
references: 18449627
references: J Pharmacol Exp Ther. 2013 Nov;347(2):375-87
references: 23995598
references: Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86
references: 22562609
references: Drug Target Insights. 2013 Aug 19;7:27-34
references: 24023511
references: Cancer Sci. 2008 Oct;99(10):2045-54
references: 19016765
references: Pharmacogenomics J. 2014 Jun;14(3):241-7
references: 23999597
references: Pharmacogenomics J. 2007 Jun;7(3):154-79
references: 16969364
references: Nucleic Acids Res. 2007;35(5):e34
references: 17267408
references: Cancer Sci. 2008 Dec;99(12):2496-501
references: 19032367