title: ERCC1 SNPs as Potential Predictive Biomarkers in Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy.
abstract: Polymorphisms in ERCC1, XPD, and XRCC1 were examined for (a) association with the clinical outcome of 107 non-small cell lung cancer patients receiving front-line platinum-based chemotherapy, and (b) correlation with the ERCC1 mRNA levels of 176 chemo-naive primary tumors. The ERCC1-C8092 allele and the number of ERCC1 polymorphic variants (C8092A and Asn118Asn) were associated with progression-free survival. In non-squamous histology, tumoral ERCC1 mRNA levels were lower in patients homozygous for ERCC1-C8092 as compared with the patients carrying the A allele (p = .024). These findings merit investigation in larger cohorts of patients treated with uniform regimens.
authors: Laboratory of Tumor Cell Biology, School of Medicine, University of Crete , Heraklion, Crete , Greece , 1.
authors: Aristea
authors: A
authors: Kalikaki
authors: Alexandra
authors: A
authors: Voutsina
authors: Anastasios
authors: A
authors: Koutsopoulos
authors: Chara
authors: C
authors: Papadaki
authors: Maria
authors: M
authors: Sfakianaki
authors: Emmanouel
authors: E
authors: Yachnakis
authors: Alexandros
authors: A
authors: Xyrafas
authors: Athanasios
authors: A
authors: Kotsakis
authors: Sofia
authors: S
authors: Agelaki
authors: John
authors: J
authors: Souglakos
authors: Dimitrios
authors: D
authors: Mavroudis
authors: Vassilis
authors: V
authors: Georgoulias
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000008:administration & dosage; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D010984:Platinum; C071447:ERCC1 protein, human; D004720:Endonucleases
keywords: ERCC1; Non-small cell lung cancer; Platinum compounds; Polymorphism; Primary tumors; mRNA levels