title: A new class of non-C2-symmetric ligands for oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketones.
abstract: We report the discovery, synthesis, and application of a new class of non-C2-symmetric phosphoramidite ligands derived from pyroglutamic acid for use in both oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketones. The resulting chiral products are typically obtained in high yield with good to excellent levels of enantioselectivity.
authors: Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
authors: Barry M
authors: BM
authors: Trost
authors: Etienne J
authors: EJ
authors: Donckele
authors: David A
authors: DA
authors: Thaisrivongs
authors: Maksim
authors: M
authors: Osipov
authors: James T
authors: JT
authors: Masters
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009943:Organophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D007659:Ketones; D008024:Ligands; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D010165:Palladium