title: Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents.
abstract: A new hybrid template designed by linking three pharmacophoric groups, for example, quinoline, triazole and dihydroquinoline moieties have been used for the generation of a library of molecules as potential cytotoxic agents. Synthesis of these polyazaheterocycles were carried out by using a strategy that involved one-pot sequential azidation and CuAAC in water under mild conditions. A number of 1,4-disubstituted 1,2,3-triazoles possessing quinolinylmethylene at N-1 and 1,2-dihydroquinolinyl methylene at C-4 as different substituents were synthesized and evaluated for their cytotoxic effects against various cancer cells. Some of them showed encouraging activities against lung cancer cells and one of them showed inhibition of PDE4 indicating the potential medicinal value of these novel polyazaheterocycles.
authors: MNR Degree & PG College, Kukatpally, Hyderabad 500085, India.
authors: Koduru Sri Shanthi
authors: KS
authors: Praveena
authors: MNR Degree & PG College, Kukatpally, Hyderabad 500085, India.
authors: Edupuganti Veera Venkat
authors: EV
authors: Shivaji Ramarao
authors: Department of Chemistry, School of Engineering, Anurag Group of Institutions, Ranga Reddy District 501301, T.S., India.
authors: Nandula Yadagiri Sreenivasa
authors: NY
authors: Murthy
authors: Chemical Biology Laboratory, Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors: Surekha
authors: S
authors: Akkenapally
authors: Chemical Biology Laboratory, Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
authors: C Ganesh
authors: CG
authors: Kumar
authors: Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
authors: Ravikumar
authors: R
authors: Kapavarapu
authors: MNR Degree & PG College, Kukatpally, Hyderabad 500085, India. Electronic address: sarbani277@yahoo.com.
authors: Sarbani
authors: S
authors: Pal
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry; D045744:Cell Line, Tumor; D015195:Drug Design; D055772:Green Chemistry Technology; D006801:Humans; D062105:Molecular Docking Simulation; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C544515:1,4-dihydroquinoline; D000970:Antineoplastic Agents; D001372:Aza Compounds; D001386:Azides; D058988:Phosphodiesterase 4 Inhibitors; D011804:Quinolines; D014230:Triazoles; C037219:quinoline
keywords: 1,2,3-Triazole; Alkyne; Azide; Cancer; PDE4; Quinoline