title: Peyronie's disease and autoimmunity—a real-life clinical study and comprehensive review.
abstract: BACKGROUND
  Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear.
  
  
  OBJECTIVE
  We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting.
  
  
  METHODS
  Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification.
  
  
  METHODS
  Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD.
  
  
  RESULTS
  PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ(2) = 24.7; P < 0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P < 0.01 and OR: 4.90; P < 0.01, respectively).
  
  
  CONCLUSIONS
  Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.
authors: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
authors: Eugenio
authors: E
authors: Ventimiglia
authors: Paolo
authors: P
authors: Capogrosso
authors: Michele
authors: M
authors: Colicchia
authors: Luca
authors: L
authors: Boeri
authors: Alessandro
authors: A
authors: Serino
authors: Giovanni
authors: G
authors: La Croce
authors: Andrea
authors: A
authors: Russo
authors: Umberto
authors: U
authors: Capitanio
authors: Alberto
authors: A
authors: Briganti
authors: Francesco
authors: F
authors: Cantiello
authors: Vincenzo
authors: V
authors: Mirone
authors: Rocco
authors: R
authors: Damiano
authors: Francesco
authors: F
authors: Montorsi
authors: Andrea
authors: A
authors: Salonia
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000453:epidemiology*; D035843:Biomedical Research; D015992:Body Mass Index; D015897:Comorbidity; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000453:epidemiology*; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: Autoimmune Disease; Peyronie's Disease; Psoriasis; Sexual Dysfunction