title: Joint modeling of cross-sectional health outcomes and longitudinal predictors via mixtures of means and variances.
abstract: Joint modeling methods have become popular tools to link important features extracted from longitudinal data to a primary event. While most modeling strategies have focused on the association between the longitudinal mean trajectories and risk of an event, we consider joint models that incorporate information from both long-term trends and short-term variability in a longitudinal submodel. We also consider both shared random effect and latent class (LC) approaches in the primary-outcome model to predict a binary outcome of interest. We develop simulation studies to compare and contrast these two modeling strategies; in particular, we study in detail the effects of the primary-outcome model misspecification. Among other findings, we note that when we analyze data from a shared random-effect using a LC model while the information from the longitudinal data is weak, the LC approach is more sensitive to such a model misspecification. Under this setting, the LC model has a superior performance in within-sample prediction that cannot be duplicated when predicting new samples. This is a unique feature of the LC approach that is new as far as we know to the existing literature. Finally, we use the proposed models to study how follicle stimulating hormone (FSH) trajectories are related to the risk of developing severe hot flashes for participating women in the Penn Ovarian Aging Study.
authors: Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors: Bei
authors: B
authors: Jiang
authors: Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, U.S.A.|Survey Methodology Program, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors: Michael R
authors: MR
authors: Elliott
authors: Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
authors: Mary D
authors: MD
authors: Sammel
authors: Department of Statistics, University of Michigan, Ann Arbor, Michigan, U.S.A.
authors: Naisyin
authors: N
authors: Wang
mesh_terms: D019540:Area Under Curve; D001699:Biometry; D003198:Computer Simulation; D003430:Cross-Sectional Studies; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000378:metabolism; D019584:Hot Flashes / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D015233:Models, Statistical; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D043373:Follicle Stimulating Hormone, Human
keywords: Joint model; Latent class; Long-term trend; Model misspecification; Predictive performance; Shared random effects and variances; Short-term variability
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