title: Calcium signalling in developing cardiomyocytes: implications for model systems and disease.
abstract: Adult cardiomyocytes exhibit complex Ca(2+) homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca(2+) sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca(2+) homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as cultured neonatal cells and stem cells.
authors: Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0424, Oslo, Norway; K. G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, 0316, Oslo, Norway.
authors: William E
authors: WE
authors: Louch
authors: Jussi T
authors: JT
authors: Koivumäki
authors: Pasi
authors: P
authors: Tavi
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002454:Cell Differentiation; D006321:Heart / Q000196:embryology* / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*
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