title: Why is factor V Leiden so rare in the Basques?
abstract: Factor V Leiden is the most common inherited trait in Caucasians that predisposes individuals to venous thrombosis. However, it is almost absent amongst the Basque people that live in the south western part of Europe. To explain this finding, we speculate upon the putative contribution of various evolutionary forces through which the Basque genome may have been shaped.
authors: Laboratoire MRGM, EA 4576, Université de Bordeaux, Bordeaux, France; Service d'Hématologie, Centre Hospitalier de la Côte Basque, Bayonne, France.
authors: F
authors: F
authors: Bauduer
mesh_terms: D005060:Europe / Q000208:ethnology; D005165:Factor V / Q000235:genetics*; D006801:Humans; D009154:Mutation
chemical_list: C095381:factor V Leiden; D005165:Factor V
keywords: epidemiology; factor V Leiden; population genetics; risk factors; venous thrombosis