title: Splenectomy-related red cell lysis resistance causing analytical difficulty in a patient with a hematological malignancy.
abstract: A patient with a history of chronic lymphocytic leukaemia and a previous splenectomy underwent full blood count analysis in a general hospital. Her medical care had previously taken place in a different institution. A CELL- DYN Sapphire analyser measured her lymphocyte count at ten-fold higher than her known baseline. The sample was sent to her previous hospital, where the laboratory utilises an ADVIA-2120i analyser. The results of this analysis were in keeping with her baseline. The spurious result appears to be related to red cell lysis resistance following splenectomy; however, this resistance appeared to be specific to the analytical method used.
authors: Barry
authors: B
authors: Kevane
authors: Anna
authors: A
authors: Dowd
authors: Aine
authors: A
authors: Lennon
authors: Christopher L
authors: CL
authors: Bacon
authors: Anne
authors: A
authors: Fortune
mesh_terms: D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D005260:Female; D006461:Hemolysis; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D018655:Lymphocyte Count; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013156:Splenectomy / Q000009:adverse effects*