title: Biasing neural network dynamics using non-invasive brain stimulation.
abstract: Recently, non-invasive brain stimulation (NBS) has been discovered as a tool to improve human performance on a wide variety of tasks. Although these observations are highly intriguing, the underlying mechanisms of such enhancements are still poorly understood. Here, we argue that in order to advance our understanding of these mechanisms it is necessary to focus on intrinsic network dynamics in the brain. Taking into account well-known network dynamics, increased excitation in one particular network or brain region may necessarily lead to inhibition of an opposing network (and vice versa). As a consequence, observed behavioral improvements due to NBS may emerge from a shift in the balance between (competing) neural networks in the brain, implicating that behavioral enhancement due to stimulation most likely comes with a cost or side effect. We conclude that more elaborate experimental designs are essential for a better understanding of the relationship between network interactions and the behavioral effects of NBS.
authors: Amsterdam Brain and Cognition, University of Amsterdam Amsterdam, Netherlands ; Consciousness, Cognition and Computation Group, Department of Psychology, Université Libre de Bruxelles Brussels, Belgium.
authors: Martijn E
authors: ME
authors: Wokke
authors: Amsterdam Brain and Cognition, University of Amsterdam Amsterdam, Netherlands ; Department of Psychology, University of Amsterdam Amsterdam, Netherlands.
authors: Lotte J
authors: LJ
authors: Talsma
authors: Amsterdam Brain and Cognition, University of Amsterdam Amsterdam, Netherlands ; Department of Psychology, University of Amsterdam Amsterdam, Netherlands.
authors: Marlies E
authors: ME
authors: Vissers
keywords: TMS; neural networks; neuromodulation; performance enhancement; tDCS
references: BMC Neurosci. 2012 Sep 10;13:108
references: 22963503
references: Curr Opin Neurobiol. 2013 Apr;23(2):162-71
references: 23294553
references: J Cogn Neurosci. 2013 Jan;25(1):74-86
references: 22905821
references: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8275-80
references: 16702548
references: Cortex. 2009 Oct;45(9):1025-34
references: 19027896
references: J Neurosci. 2013 Mar 6;33(10):4482-6
references: 23467363
references: J Neurosci. 2013 Mar 20;33(12):5411-21
references: 23516306
references: Front Hum Neurosci. 2012 Jan 03;5:183
references: 22287947
references: Neuroimage. 2014 Jan 15;85 Pt 3:934-47
references: 23727025
references: Neuroimage. 2014 Jan 15;85 Pt 3:961-70
references: 23770409
references: Brain Stimul. 2011 Apr;4(2):84-9
references: 21511208
references: J Cogn Neurosci. 2014 Feb;26(2):365-79
references: 24116840
references: Clin Neurophysiol. 2009 Dec;120(12):2008-39
references: 19833552
references: Nat Neurosci. 2006 Jul;9(7):971-8
references: 16767087
references: Neurosci Lett. 2012 May 2;515(2):121-4
references: 22440856
references: Neuroreport. 1998 Jul 13;9(10):2257-60
references: 9694210
references: Exp Brain Res. 2005 Sep;166(1):23-30
references: 15999258
references: Trends Cogn Sci. 2008 Dec;12(12):447-54
references: 18951833
references: J Physiol. 2000 Sep 15;527 Pt 3:633-9
references: 10990547
references: J Cogn Neurosci. 2003 Apr 1;15(3):394-408
references: 12729491
references: Brain. 2002 Oct;125(Pt 10):2238-47
references: 12244081
references: Nat Neurosci. 2001 Sep;4(9):953-7
references: 11528429
references: Eur J Neurosci. 2007 Mar;25(6):1874-81
references: 17408427
references: Neuroimage. 2014 Jan 15;85 Pt 3:895-908
references: 23933040
references: Neuroimage. 2008 Jan 1;39(1):527-37
references: 17919929
references: Neuron. 1999 Aug;23(4):747-64
references: 10482241
references: Neuroimage. 2014 Jan 15;85 Pt 3:1058-68
references: 23880500
references: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references: 15976020
references: J Neurosci. 2011 Oct 26;31(43):15284-93
references: 22031874
references: Curr Biol. 2010 Nov 23;20(22):2016-20
references: 21055945
references: Proc Biol Sci. 1998 Mar 22;265(1395):537-43
references: 9569672
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2):676-82
references: 11209064
references: Front Syst Neurosci. 2014 Feb 24;8:25
references: 24605090
references: Lancet. 1985 May 11;1(8437):1106-7
references: 2860322
references: Magn Reson Imaging. 2010 Oct;28(8):1051-7
references: 20409665
references: Stroke. 2003 Jun;34(6):1553-66
references: 12738893
references: Front Hum Neurosci. 2013 Sep 24;7:602
references: 24068995
references: Brain. 2011 Dec;134(Pt 12):3742-54
references: 22006979
references: Brain Stimul. 2012 Jul;5(3):252-63
references: 21962981