title: Impact of energy devices during liver parenchymal transection: a multicenter randomized controlled trial.
abstract: OBJECTIVE
  To clarify the benefit of energy devices such as ultrasonically activated device and bipolar vessel sealing device in liver surgeries.
  
  
  BACKGROUND
  Several studies have suggested the benefit of energy devices in liver transection, while a randomized trial has found no association between their use and surgical outcomes.
  
  
  METHODS
  Patients scheduled to undergo open liver resection were eligible for this multicenter non-blinded randomized study. They were randomized to receive an energy device (experimental group) or not (control group) during liver transection. The primary endpoint was the proportion of patients with intraoperative blood loss >1,000 mL. The primary aim was to show non-inferiority of hepatectomy with energy device to that without energy device.
  
  
  RESULTS
  A total of 212 patients were randomized and 211 (105 and 106 in the respective groups) were analyzed. Intraoperative blood loss >1,000 mL occurred in 15.0% patients with energy device and 20.2% patients without energy device. The experimental minus control group difference was -5.2% (95% confidence interval -13.8 to 3.3%; non-inferiority test, p = 0.0248). Hepatectomy with energy device resulted in a shorter median liver transection time (63 vs. 84 min; p < 0.001) and a lower rate of postoperative bile leakage (4 vs. 16%; p = 0.002).
  
  
  CONCLUSIONS
  The hypothesis that hepatectomy with energy device is not inferior to that without energy device in terms of blood loss has been demonstrated. The use of energy devices during liver surgery is clinically meaningful as it shortens the liver transection time and reduces the incidence of postoperative bile leakage.
authors: Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan, ngotohda@east.ncc.go.jp.
authors: Naoto
authors: N
authors: Gotohda
authors: Takeharu
authors: T
authors: Yamanaka
authors: Akio
authors: A
authors: Saiura
authors: Katsuhiko
authors: K
authors: Uesaka
authors: Masaji
authors: M
authors: Hashimoto
authors: Masaru
authors: M
authors: Konishi
authors: Kazuaki
authors: K
authors: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057868:Anastomotic Leak / Q000209:etiology / Q000517:prevention & control; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001810:Blood Volume; D005260:Female; D006488:Hemostasis, Surgical / Q000295:instrumentation* / Q000379:methods; D006498:Hepatectomy / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D016896:Treatment Outcome; D014465:Ultrasonics
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