title: [Amyotrophic lateral sclerosis].
abstract: Amyotrophic lateral sclerosis (ALS) is an aggressive degeneration of upper and lower motor neurons and thus affects both the central and the peripheral nervous system. Clinically, the disease is characterized by rapidly progressing atrophy and paresis of all muscle groups with a letal outcome after three to six years due to paresis of the respiratory muscles. So far, no causal treatment is known.
authors: Annemarie
authors: A
authors: Hübers
authors: Jochen H
authors: JH
authors: Weishaupt
authors: Albert C
authors: AC
authors: Ludolph
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009046:Motor Neurons / Q000473:pathology