title: Evaluation of neo-adjuvant, concurrent and adjuvant chemotherapy in the treatment of head and neck squamous cell carcinoma: a meta-analysis.
abstract: OBJECTIVE
  Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity. This study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.
  
  
  METHODS
  The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011. Data of the evaluated treatment procedures (chemotherapy or radiotherapy), number of patients, publishing date and the authors' names have all been extracted from the articles and have been categorized in a table.
  
  
  RESULTS
  Forty-six researches are included in this study. All three ways show that using chemotherapy after or with radiotherapy improves the vitality rate significantly (p-value< 0.01).
  
  
  CONCLUSIONS
  It is concluded that after deciding not to perform a surgery for treating SCC, the recommended treatment plan is chemotherapy and radiotherapy simultaneously.
authors: Associate Professor,, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Fahimeh
authors: F
authors: Akhlaghi
authors: Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Esmaeelinejad
authors: Dental Researcher, Dental Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors: Amin
authors: A
authors: Shams
authors: Private Practice, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medica Sciences, Tehran, Iran.
authors: Arsalan
authors: A
authors: Augend
keywords: Carcinoma; Chemotherapy; Meta-Analysis; Radiotherapy; Squamous Cell
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