title: Factors contributing to the duration of untreated prodromal positive symptoms in individuals at ultra-high risk for psychosis.
abstract: Individuals at ultra-high risk (UHR) for psychosis experience a considerable delay before appropriate clinical attention is provided. Therefore, we investigated the correlates of this delay by examining clinical, socio-demographic and neuropsychological contributors to the duration of untreated prodromal positive symptoms (DUPP) in them (n=73). The slowly progressive mode of functional decline, defined as a small percentage drop in the Global Assessment of Functioning (GAF) score within the past year, and male gender, explained a considerable portion of the DUPP in the multivariate regression model (F=9.269, p<0.001). Slower functional decline may be correlated with delayed care during the UHR period.
authors: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Myong-Wuk
authors: MW
authors: Chon
authors: Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
authors: Tae Young
authors: TY
authors: Lee
authors: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Sung Nyun
authors: SN
authors: Kim
authors: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Min Jung
authors: MJ
authors: Huh
authors: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Hye Youn
authors: HY
authors: Park
authors: Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
authors: Cho Rong
authors: CR
authors: Lee
authors: Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
authors: Na Young
authors: NY
authors: Shin
authors: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea; Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. Electronic address: kwonjs@snu.ac.kr.
authors: Jun Soo
authors: JS
authors: Kwon
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008960:Models, Psychological; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D012044:Regression Analysis; D012306:Risk; D061665:Time-to-Treatment; D055815:Young Adult
keywords: Delayed care; Duration of untreated prodromal positive symptoms; Functional decline; Psychosis; Ultra-high risk for psychosis