title: How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.
abstract: Bacterial type II fatty acid synthesis (FASII) is a target for the development of novel therapeutics. Bacteria incorporate extracellular fatty acids into membrane lipids, raising the question of whether pathogens use host fatty acids to bypass FASII and defeat FASII therapeutics. Some pathogens suppress FASII when exogenous fatty acids are present to bypass FASII therapeutics. FASII inhibition cannot be bypassed in many bacteria because essential fatty acids cannot be obtained from the host. FASII antibiotics may not be effective against all bacteria, but a broad spectrum of Gram-negative and -positive pathogens can be effectively treated with FASII inhibitors.
authors: From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
authors: Jiangwei
authors: J
authors: Yao
authors: From the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105 charles.rock@stjude.org.
authors: Charles O
authors: CO
authors: Rock
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000472:pathogenicity; D054889:Fatty Acid Synthase, Type II / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis / Q000378:metabolism*; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D050155:Lipogenesis / Q000235:genetics; D008563:Membrane Lipids / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D008563:Membrane Lipids; D054889:Fatty Acid Synthase, Type II
keywords: Antibiotics; Bacteria; FASII; Fatty Acid; Fatty Acid Synthase (FAS); Fatty Acid Transport; Phospholipid
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