title: Tobacco smoke in infants with bronchopulmonary dysplasia.
abstract: Exposure to tobacco smoke has been not evaluated in children with bronchopulmonary dysplasia (BPD). We evaluate the association of in utero smoking (IUS) and environmental tobacco smoke (ETS) with the respiratory events of BPD and non-BPD children. Two hundred sixty-two children born before 35 weeks of gestational age (GA) and regularly followed up in our regional network for preterms were enrolled. They were paired according to their BPD status, their gestational age and birth weight (131 children with BPD and 131 without BPD, 28 mean weeks GA; mean weight 1000 g). Respiratory data were obtained prospectively during their first 2 years of life. A complementary questionnaire was completed by the parents about their child's respiratory health at the age of 2, their home environment, and tobacco status. IUS concerned 12.6 %; ETS, 48.8 % (67 % in BPD children treated with oxygen at home). No further influence on respiratory outcome could be found by exposure to intrauterine smoke or extrauterine tobacco smoke in this patient sample.
  
  
  CONCLUSIONS
  IUS and ETS exposures are as high in preterm children as in a general pediatric population. The highest exposure occurs among BPD infants treated with oxygen at home.
  
  
  BACKGROUND
  • Environmental tobacco smoke (ETS) and in utero smoking (IUS) are responsible for many morphological, functional, and clinical changes in children. • Children with bronchopulmonary dysplasia (BPD) have more respiratory events in their first years of life than preterm children without BPB, maybe triggered by ETS and IUS. What is New: • The exposition to ETS and IUS is high in preterm children with and without BDP, as high as in a general. • Pedaitric population, particularly in children with BPD and treated with oxygen at home. • No further influence on respiratory outcome could be found by exposure to ETS or IUS in our studied population.
authors: Unité de pneumologie infantile, CHU Timone-Enfants, 264 rue Saint Pierre, 13385, Marseille CEDEX 5, France, stephanie.martinez2@ap-hm.fr.
authors: Stéphanie
authors: S
authors: Martinez
authors: Patricia
authors: P
authors: Garcia-Meric
authors: Véronique
authors: V
authors: Millet
authors: Mellie
authors: M
authors: Aymeric-Ponsonnet
authors: Khuder
authors: K
authors: Alagha
authors: Jean-Christophe
authors: JC
authors: Dubus
mesh_terms: D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000628:therapy; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology*; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data*
chemical_list: D014028:Tobacco Smoke Pollution
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