title: Tendon functional extracellular matrix.
abstract: This article is one of a series, summarizing views expressed at the Orthopaedic Research Society New Frontiers in Tendon Research Conference. This particular article reviews the three workshops held under the "Functional Extracellular Matrix" stream. The workshops focused on the roles of the tendon extracellular matrix, such as performing the mechanical functions of tendon, creating the local cell environment, and providing cellular cues. Tendon is a complex network of matrix and cells, and its biological functions are influenced by widely varying extrinsic and intrinsic factors such as age, nutrition, exercise levels, and biomechanics. Consequently, tendon adapts dynamically during development, aging, and injury. The workshop discussions identified research directions associated with understanding cell-matrix interactions to be of prime importance for developing novel strategies to target tendon healing or repair.
authors: Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom.
authors: Hazel R C
authors: HR
authors: Screen
authors: David E
authors: DE
authors: Berk
authors: Karl E
authors: KE
authors: Kadler
authors: Francesco
authors: F
authors: Ramirez
authors: Marian F
authors: MF
authors: Young
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D013710:Tendons / Q000737:chemistry / Q000502:physiology*
keywords: cell; collagen; hierarchy; mechanics; proteoglycans; structure; tendinopathy; tenocyte
references: Philos Trans R Soc Lond B Biol Sci. 2002 Feb 28;357(1418):121-32
references: 11911769
references: Eur Cell Mater. 2010;20:84-97
references: 20661865
references: Ann Rheum Dis. 1994 Jun;53(6):359-66
references: 8037494
references: J Anat. 1998 Nov;193 ( Pt 4):481-94
references: 10029181
references: Cell Tissue Res. 2010 Jan;339(1):71-82
references: 19513754
references: Nat Protoc. 2013;8(7):1433-48
references: 23807286
references: PLoS One. 2013;8(12):e83836
references: 24349551
references: Int J Exp Pathol. 2013 Aug;94(4):248-59
references: 23718692
references: Acta Biomater. 2013 Aug;9(8):7948-56
references: 23669621
references: Matrix Biol. 2013 Jan;32(1):3-13
references: 23178232
references: Bone Joint Res. 2014 Aug;3(8):252-61
references: 25106417
references: Nat Med. 2007 Oct;13(10):1219-27
references: 17828274
references: J Physiol. 2003 Dec 1;553(Pt 2):335-43
references: 12923209
references: Nat Clin Pract Rheumatol. 2008 Feb;4(2):82-9
references: 18235537
references: Equine Vet J. 2013 Jul;45(4):398-400
references: 23738877
references: Nat Rev Rheumatol. 2010 May;6(5):262-8
references: 20308995
references: Acta Biomater. 2014 Jul;10(7):3217-24
references: 24747261
references: Equine Vet J. 2003 May;35(3):314-8
references: 12755437
references: Ann Biomed Eng. 2014 Mar;42(3):619-30
references: 24072490
references: Odontology. 2016 Jan;104(1):35-43
references: 25316032
references: Scand J Med Sci Sports. 2002 Apr;12(2):90-8
references: 12121426
references: Biochemistry. 1996 Jul 9;35(27):8795-9
references: 8688414
references: ILAR J. 2014;55(1):86-99
references: 24936032
references: Stem Cells Dev. 2015 Mar 1;24(5):597-609
references: 25351164
references: J Biomech Eng. 2004 Apr;126(2):252-7
references: 15179856
references: J Orthop Res. 2009 Feb;27(2):257-63
references: 18683890
references: J Bone Joint Surg Am. 2013 Sep 4;95(17):1620-8
references: 24005204
references: J Biol Chem. 1999 Apr 2;274(14):9636-47
references: 10092650
references: J R Soc Interface. 2012 Nov 7;9(76):3108-17
references: 22764132
references: Scand J Med Sci Sports. 2009 Aug;19(4):536-46
references: 19422643
references: Med Eng Phys. 2013 Jan;35(1):96-102
references: 22652381
references: Disabil Rehabil. 2008;30(20-22):1523-9
references: 18665569
references: J Biomech. 2012 Jan 3;45(1):59-65
references: 22055428
references: Int J Exp Pathol. 2007 Aug;88(4):217-26
references: 17696902
references: J Orthop Res. 2014 Sep;32(9):1097-103
references: 24838769
references: Bone Joint Res. 2012 Jul 01;1(7):158-66
references: 23610686
references: Matrix Biol. 2004 May;23(2):127-40
references: 15246111
references: Connect Tissue Res. 1978;6(1):11-23
references: 149646
references: Arthritis Rheum. 2013 Sep;65(9):2334-45
references: 23896777
references: Connect Tissue Res. 1989;19(1):51-62
references: 2477190
references: Dev Dyn. 1995 Mar;202(3):229-43
references: 7780173
references: Nucleic Acids Res. 2012 Apr;40(8):3419-30
references: 22210883
references: Dev Dyn. 1997 Mar;208(3):291-8
references: 9056634
references: FASEB J. 2013 May;27(5):2074-9
references: 23401563
references: Acta Biomater. 2006 Sep;2(5):505-13
references: 16839828
references: Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4743-52
references: 24248360
references: J Musculoskelet Neuronal Interact. 2005 Mar;5(1):22-34
references: 15788868
references: J Anat. 1996 Dec;189 ( Pt 3):593-600
references: 8982835
references: J Orthop Res. 2012 Apr;30(4):620-6
references: 21928430
references: Prog Brain Res. 2006;153:177-88
references: 16876575
references: J Anat. 2006 Apr;208(4):445-50
references: 16637870
references: J Musculoskelet Neuronal Interact. 2004 Jun;4(2):202-3
references: 15615127
references: J Bone Joint Surg Am. 2008 Apr;90(4):803-14
references: 18381319
references: J Orthop Res. 2011 Mar;29(3):384-9
references: 20886657
references: Anat Rec. 2002 Dec 1;268(4):430-40
references: 12420291
references: J Mech Behav Biomed Mater. 2014 Oct;38:163-72
references: 25001495
references: Biochem J. 2014 Oct 1;463(1):1-8
references: 25195734
references: Dev Biol. 1979 Aug;71(2):228-42
references: 499658
references: J Biomech. 2010 Jan 19;43(2):274-9
references: 19939387
references: Equine Vet J Suppl. 2002 Sep;(34):241-4
references: 12405694
references: Tissue Eng. 2006 Dec;12(12):3307-39
references: 17518671
references: J Appl Physiol (1985). 2008 Oct;105(4):1026-7
references: 18687974
references: J Cell Biol. 1986 Jul;103(1):231-40
references: 3722266
references: Biopolymers. 1977 May;16(5):1015-31
references: 861363
references: J Biol Chem. 2010 May 21;285(21):15674-81
references: 20308077
references: Scand J Med Sci Sports. 2013 Feb;23(1):31-7
references: 22092479
references: Bone Joint Res. 2014 Jun;3(6):193-202
references: 24958818
references: Scand J Med Sci Sports. 2015 Aug;25(4):e381-91
references: 25639911
references: J Biol Chem. 2012 Oct 5;287(41):33926-33
references: 22879588
references: J Cell Biol. 2000 Nov 13;151(4):779-88
references: 11076963
references: J Cell Biol. 2004 May 24;165(4):553-63
references: 15159420
references: Proc Inst Mech Eng H. 2004;218(2):109-19
references: 15116898
references: Biorheology. 2003;40(1-3):361-8
references: 12454427
references: Int J Exp Pathol. 2007 Aug;88(4):241-8
references: 17696905
references: Sci Rep. 2014;4:5183
references: 24897937
references: PLoS One. 2014;9(3):e92474
references: 24651449
references: Eur Cell Mater. 2013;25:48-60
references: 23300032