title: Transient Sp8+ handlebar-like interneuron structure traversing the corpus callosum during the second postnatal week.
abstract: Although previous studies have implied that interneurons continue to migrate into the corpus callosum (CC) during the postnatal period, little is known about the details of the migration pattern. In this study, we analyzed the entire postnatal CC every other day and showed the presence of a transient handlebar-like structure traversing the CC during the second postnatal week. Using immunostaining and two strains of transgenic mice, we showed that this handlebar-like structure consisted of GABAergic interneurons derived from the caudal ganglionic eminence, which expressed the transcription factor Sp8. Data obtained from in-utero electroporation experiments showed that these high-density interneurons were adjacent to callosal axons. Thus, we provide the first direct evidence that a transient Sp8+ interneuron handlebar-like structure exists in the CC during a brief postnatal critical period.
authors: aDepartment of Molecular and Cell Biology, College of Life Science, Tongji University, Shanghai bDepartment of Neurosurgery cDepartment of Neurology, Affiliated Hospital of Hebei University of Engineering, Handan, China.
authors: Yuqun
authors: Y
authors: Cai
authors: Kun
authors: K
authors: She
authors: Congmin
authors: C
authors: Wang
mesh_terms: D000818:Animals; D002465:Cell Movement; D003337:Corpus Callosum / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007395:Interneurons / Q000166:cytology* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C490035:Sp8 protein, mouse; D014157:Transcription Factors