title: Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
abstract: BACKGROUND
  Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent influences (e.g., relating to incorporation, metabolism, or intercompetition with other fatty acids) that could alter circulating concentrations and possibly modulate or mediate impacts on health.
  
  
  OBJECTIVE
  The objective was to elucidate novel biologic pathways that may influence circulating TFAs by evaluating associations between common genetic variation and TFA biomarkers.
  
  
  METHODS
  We performed meta-analyses using 7 cohorts of European-ancestry participants (n = 8013) having measured genome-wide variation in single-nucleotide polymorphisms (SNPs) and circulating TFA biomarkers (erythrocyte or plasma phospholipids), including trans-16:1n-7, total trans-18:1, trans/cis-18:2, cis/trans-18:2, and trans/trans-18:2. We further evaluated SNPs with genome-wide significant associations among African Americans (n = 1082), Chinese Americans (n = 669), and Hispanic Americans (n = 657) from 2 of these cohorts.
  
  
  RESULTS
  Among European-ancestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with cis/trans-18:2; a top hit was rs174548 (β = 0.0035, P = 4.90 × 10(-15)), an SNP previously associated with circulating n-3 and n-6 polyunsaturated fatty acid concentrations. No significant association was identified for other TFAs. rs174548 in FADS1/2 was also associated with cis/trans-18:2 in Hispanic Americans (β = 0.0053, P = 1.05 × 10(-6)) and Chinese Americans (β = 0.0028, P = 0.002) but not African Americans (β = 0.0009, P = 0.34); however, in African Americans, fine mapping identified a top hit in FADS2 associated with cis/trans-18:2 (rs174579: β = 0.0118, P = 4.05 × 10(-5)). The association between rs174548 and cis/trans-18:2 remained significant after further adjustment for individual circulating n-3 and n-6 fatty acids, except arachidonic acid. After adjustment for arachidonic acid concentrations, the association between rs174548 and cis/trans-18:2 was nearly eliminated in European-ancestry participants (β-coefficient reduced by 86%), with similar reductions in Hispanic Americans and Chinese Americans.
  
  
  CONCLUSIONS
  Our findings provide novel evidence for genetic regulation of cis/trans-18:2 by the FADS1/2 cluster and suggest that this regulation may be influenced/mediated by concentrations of arachidonic acid, an n-6 polyunsaturated fat.
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Dariush
authors: D
authors: Mozaffarian
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Edmond K
authors: EK
authors: Kabagambe
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Catherine O
authors: CO
authors: Johnson
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Rozenn N
authors: RN
authors: Lemaitre
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Ani
authors: A
authors: Manichaikul
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Qi
authors: Q
authors: Sun
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Millennia
authors: M
authors: Foy
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Lu
authors: L
authors: Wang
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Howard
authors: H
authors: Wiener
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Marguerite R
authors: MR
authors: Irvin
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Stephen S
authors: SS
authors: Rich
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Hongyu
authors: H
authors: Wu
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Majken K
authors: MK
authors: Jensen
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Daniel I
authors: DI
authors: Chasman
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Audrey Y
authors: AY
authors: Chu
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Myriam
authors: M
authors: Fornage
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Lyn
authors: L
authors: Steffen
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Irena B
authors: IB
authors: King
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Barbara
authors: B
authors: McKnight
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Bruce M
authors: BM
authors: Psaty
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Luc
authors: L
authors: Djoussé
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Ida Y-D
authors: IY
authors: Chen
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Jason H Y
authors: JH
authors: Wu
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: David S
authors: DS
authors: Siscovick
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Paul M
authors: PM
authors: Ridker
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Michael Y
authors: MY
authors: Tsai
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Eric B
authors: EB
authors: Rimm
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Frank B
authors: FB
authors: Hu
authors: From the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
authors: Donna K
authors: DK
authors: Arnett
mesh_terms: D001741:Black or African American / Q000235:genetics; D016718:Arachidonic Acid / Q000097:blood; D001213:Asian / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D000090943:Delta-5 Fatty Acid Desaturase; D043371:Fatty Acids, Omega-6 / Q000097:blood; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D056426:Genetic Loci; D060005:Genotyping Techniques; D006801:Humans; D010743:Phospholipids / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D044242:Trans Fatty Acids / Q000097:blood*; D044465:White People / Q000235:genetics
chemical_list: D015415:Biomarkers; D000090943:Delta-5 Fatty Acid Desaturase; D043371:Fatty Acids, Omega-6; D010743:Phospholipids; D044242:Trans Fatty Acids; D016718:Arachidonic Acid; C000716847:FADS1 protein, human
keywords: arachidonic acid; genome-wide association; meta-analysis; phospholipid; trans fatty acids
references: Prog Lipid Res. 2014 Jan;53:108-23
references: 24345640
references: Circulation. 2006 Jul 18;114(3):209-15
references: 16818809
references: J Lipid Res. 2012 Jun;53(6):1183-9
references: 22451038
references: Genet Epidemiol. 2010 Jan;34(1):100-5
references: 19434714
references: Nat Rev Endocrinol. 2009 Jun;5(6):335-44
references: 19399016
references: Am J Clin Nutr. 2010 Jul;92(1):258-65
references: 20484448
references: Am J Clin Nutr. 2004 Dec;80(6):1521-5
references: 15585763
references: Circ Cardiovasc Genet. 2009 Feb;2(1):73-80
references: 20031568
references: Genet Epidemiol. 2011 Apr;35(3):154-8
references: 21254223
references: Curr Top Med Chem. 2011;11(6):629-47
references: 21261595
references: Nat Genet. 2007 Jul;39(7):906-13
references: 17572673
references: Circulation. 2002 Feb 12;105(6):697-701
references: 11839624
references: Nature. 2010 Aug 5;466(7307):707-13
references: 20686565
references: PLoS One. 2012;7(9):e44926
references: 23028684
references: N Engl J Med. 2006 Apr 13;354(15):1601-13
references: 16611951
references: PLoS One. 2012;7(7):e41681
references: 22911844
references: PLoS Genet. 2007 Jul;3(7):e114
references: 17676998
references: Hum Mol Genet. 2010 Oct 1;19(19):3885-94
references: 20639392
references: Circ Cardiovasc Genet. 2014 Jun;7(3):321-31
references: 24823311
references: Nat Genet. 2011 Apr;43(4):333-8
references: 21378990
references: Am J Hum Genet. 2009 Feb;84(2):210-23
references: 19200528
references: Am J Clin Nutr. 2006 Feb;83(2):227-36
references: 16469979
references: PLoS Genet. 2011 Jul;7(7):e1002193
references: 21829377
references: Am J Clin Nutr. 2010 Apr;91(4):883-93
references: 20219966
references: Am J Clin Nutr. 2004 Apr;79(4):606-12
references: 15051604
references: Nat Genet. 2009 Jan;41(1):47-55
references: 19060911
references: Br J Nutr. 2012 Feb;107(4):547-55
references: 21733300
references: N Engl J Med. 2011 Nov 10;365(19):1812-23
references: 22070478
references: Am J Clin Nutr. 2008 Oct;88(4):941-9
references: 18842780
references: Pharmacogenet Genomics. 2012 Mar;22(3):191-7
references: 22228203
references: BMC Genet. 2011;12:50
references: 21599946
references: PLoS One. 2013;8(1):e55869
references: 23383292
references: Nat Genet. 2009 Jan;41(1):56-65
references: 19060906
references: Front Genet. 2012 May 03;3:72
references: 22563332
references: Ann Intern Med. 2010 Dec 21;153(12):790-9
references: 21173413
references: Circ Cardiovasc Genet. 2013 Apr;6(2):171-83
references: 23362303
references: Am J Clin Nutr. 2010 Nov;92(5):1214-22
references: 20861175
references: PLoS Genet. 2009 Jan;5(1):e1000338
references: 19148276
references: Atherosclerosis. 2011 Jan;214(1):94-100
references: 21040914
references: Nat Genet. 2010 Feb;42(2):105-16
references: 20081858