title: Effects of atmospheric pressure plasmas on isolated and cellular DNA-a review.
abstract: Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes.
authors: Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA. karjunan@nd.edu.
authors: Krishna Priya
authors: KP
authors: Arjunan
authors: Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, 1266 TAMU, College Station, TX 77843, USA. vsharma@sph.tamhsc.edu.
authors: Virender K
authors: VK
authors: Sharma
authors: Radiation Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA. sptasins@nd.edu.
authors: Sylwia
authors: S
authors: Ptasinska
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000528:radiation effects; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage / Q000528:radiation effects; D006801:Humans; D009705:Nucleosides / Q000737:chemistry; D058626:Plasma Gases / Q000633:toxicity; D026361:Reactive Nitrogen Species / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D009705:Nucleosides; D058626:Plasma Gases; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D004247:DNA; D064007:Ataxia Telangiectasia Mutated Proteins
references: Phys Chem Chem Phys. 2010 Jul 28;12(28):7779-81
references: 20556293
references: Appl Biochem Biotechnol. 2013 Dec;171(7):1617-29
references: 23982422
references: Free Radic Res Commun. 1987;2(4-6):343-50
references: 2849589
references: EMBO J. 1993 Sep;12(9):3679-84
references: 8253089
references: Physiol Rev. 2002 Jan;82(1):47-95
references: 11773609
references: Oncogene. 2006 Jun 29;25(28):3894-904
references: 16474843
references: Med Gas Res. 2013 Oct 01;3(1):21
references: 24083477
references: Expert Rev Med Devices. 2013 May;10(3):367-77
references: 23668708
references: Cell Res. 2008 Jan;18(1):134-47
references: 18157161
references: Proteomics. 2011 Sep;11(17):3518-30
references: 21751354
references: Environ Res. 2003 Nov;93(3):279-84
references: 14615238
references: Appl Phys Lett. 2010 Jun 14;96(24):243701
references: 20628488
references: Br J Dermatol. 2012 Aug;167(2):404-10
references: 22385038
references: Nucleic Acids Res. 1990 Feb 11;18(3):631-5
references: 2155406
references: Cell Cycle. 2008 Sep 15;7(18):2902-6
references: 18769152
references: Cell Signal. 2010 Jul;22(7):1003-12
references: 20100570
references: Biomolecules. 2014 Jul 17;4(3):678-703
references: 25036887
references: Arch Biochem Biophys. 2014 Mar 1;545:133-40
references: 24486404
references: J R Soc Interface. 2013 Sep 25;10(89):20130591
references: 24068175
references: J Biol Chem. 1993 Oct 25;268(30):22369-76
references: 8226748
references: Arch Biochem Biophys. 2014 Oct 15;560:1-9
references: 25086216
references: Int J Antimicrob Agents. 2014 Feb;43(2):154-60
references: 24139886
references: Mutat Res. 2005 Aug 1;585(1-2):60-70
references: 15923135
references: Infect Control Hosp Epidemiol. 2008 May;29(5):430-6
references: 18419365
references: J Am Chem Soc. 2012 Oct 31;134(43):18053-64
references: 23057664
references: Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10032-7
references: 10944195
references: Neuroscience. 2007 Apr 14;145(4):1187-200
references: 16934943
references: Mutat Res. 1992 Sep;275(3-6):367-75
references: 1383777
references: Antimicrob Agents Chemother. 2011 Mar;55(3):1053-62
references: 21199923
references: Mutat Res. 2003 Oct 29;531(1-2):231-51
references: 14637258
references: Nat Rev Neurosci. 2009 Feb;10(2):100-12
references: 19145234
references: Chem Res Toxicol. 1997 Apr;10(4):386-92
references: 9114974
references: Genome Integr. 2010 Nov 05;1(1):15
references: 21054854
references: Biochem Mol Biol Educ. 2008;37(1):2-10
references: 19225573
references: BMC Cancer. 2012 Oct 15;12:473
references: 23066891
references: Appl Environ Microbiol. 2012 Aug;78(15):5077-82
references: 22582068
references: J Dermatol Sci. 2013 Jun;70(3):173-81
references: 23619096
references: J Biotechnol. 2006 Feb 10;121(3):299-308
references: 16216376
references: Chem Res Toxicol. 1995 Apr-May;8(3):379-88
references: 7578924
references: Biochim Biophys Acta. 1991 Mar 26;1088(3):409-12
references: 2015303
references: J Microbiol. 2006 Aug;44(4):466-71
references: 16953185
references: Free Radic Biol Med. 1991;10(3-4):225-42
references: 1650738
references: Nat Cell Biol. 2006 Jan;8(1):37-45
references: 16327781
references: Free Radic Biol Med. 2000 May 1;28(9):1387-404
references: 10924858
references: Am J Pathol. 1990 Mar;136(3):593-608
references: 2156431
references: Int J Radiat Biol. 1998 Oct;74(4):511-9
references: 9798962
references: J Biol Chem. 2006 Apr 7;281(14):9346-50
references: 16431910
references: J Dent Sci. 2016 Mar;11(1):65-71
references: 30894948
references: J Biol Chem. 2004 Jul 30;279(31):32106-15
references: 15152004
references: PLoS One. 2013 Jun 14;8(6):e66231
references: 23799081
references: J Bacteriol. 1995 Dec;177(23):6782-90
references: 7592468
references: Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12871-6
references: 14566050
references: J Biol Chem. 2001 Dec 21;276(51):47759-62
references: 11673449
references: J Nucleic Acids. 2010 Jul 25;2010:
references: 20725631
references: Appl Environ Microbiol. 2012 Jun;78(12):4242-7
references: 22467505
references: J Appl Microbiol. 2013 Sep;115(3):689-702
references: 23758316
references: J Gen Virol. 2005 Aug;86(Pt 8):2393-2399
references: 16033987
references: Mol Biol Cell. 2002 Mar;13(3):978-88
references: 11907276
references: Chem Res Toxicol. 1994 Jul-Aug;7(4):568-74
references: 7981422
references: Methods Mol Biol. 2012;920:613-26
references: 22941631
references: Free Radic Biol Med. 1995 Jun;18(6):1033-77
references: 7628729
references: J Biol Chem. 1987 Apr 5;262(10):4724-7
references: 3031031
references: Arch Biochem Biophys. 2004 Mar 1;423(1):12-22
references: 14989259
references: Br J Exp Pathol. 1989 Dec;70(6):737-57
references: 2557883
references: Photochem Photobiol Sci. 2002 Apr;1(4):225-36
references: 12661961
references: J Exp Med. 2006 Feb 20;203(2):297-303
references: 16461339
references: J Neurochem. 2006 Jun;97(6):1634-58
references: 16805774
references: Chem Res Toxicol. 2008 Feb;21(2):276-81
references: 18189366
references: J Cell Biochem. 2007 Mar 1;100(4):883-96
references: 17031865
references: DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1109-15
references: 15279799
references: PLoS One. 2014 Apr 23;9(4):e91947
references: 24759730
references: Chem Res Toxicol. 2013 Jul 15;26(7):1031-3
references: 23734842
references: EMBO J. 1998 Sep 15;17(18):5497-508
references: 9736627
references: FEBS Lett. 1991 Apr 9;281(1-2):9-19
references: 1849843
references: Arch Dermatol Res. 2013 Mar;305(2):133-40
references: 22773133
references: Environ Mol Mutagen. 2001;38(2-3):180-90
references: 11746753
references: J Appl Microbiol. 2014 Apr;116(4):784-94
references: 24372804
references: Cancer Res. 1993 Sep 1;53(17):3976-85
references: 8358726
references: J Am Chem Soc. 1973 Feb 21;95(4):1029-35
references: 4687681
references: Radiat Res. 1991 May;126(2):251-9
references: 1850853
references: Chem Res Toxicol. 2001 Jul;14(7):927-38
references: 11453741
references: Cytometry A. 2004 Apr;58(2):99-110
references: 15057963
references: Br J Dermatol. 2010 Jul;163(1):78-82
references: 20222930
references: PLoS One. 2011 Jan 21;6(1):e16270
references: 21283714
references: PLoS One. 2013 Oct 11;8(10):e77046
references: 24319517
references: Chem Res Toxicol. 2011 Jul 18;24(7):1144-52
references: 21513308
references: PLoS One. 2012;7(3):e33245
references: 22432007
references: Apoptosis. 2000 Nov;5(5):415-8
references: 11256882
references: J Appl Microbiol. 2009 Nov;107(5):1440-9
references: 19426273
references: Cell Biol Int. 2014 Apr;38(4):412-25
references: 24155089
references: Biochemistry. 2000 Jun 27;39(25):7559-69
references: 10858306
references: EMBO J. 2006 Dec 13;25(24):5775-82
references: 17124492
references: Arch Biochem Biophys. 2014 Sep 1;557:47-54
references: 24820329
references: Radiat Res. 2013 Jun;179(6):669-73
references: 23642044
references: Physiol Rev. 2007 Jan;87(1):315-424
references: 17237348
references: Appl Microbiol Biotechnol. 2012 Mar;93(6):2563-70
references: 22075631
references: J Surg Res. 2013 Jan;179(1):e1-e12
references: 22480830
references: J Appl Microbiol. 2010 Mar;108(3):851-858
references: 19735332
references: Chemphyschem. 2009 Jul 13;10(9-10):1426-30
references: 19308972
references: J R Soc Interface. 2012 Jan 7;9(66):147-57
references: 21653568
references: Photochem Photobiol. 1978 Oct-Nov;28(4-5):661-7
references: 216029
references: Int J Cancer. 2012 May 1;130(9):2185-94
references: 21702038
references: Sci Rep. 2012;2:636
references: 22957140
references: Nucleic Acids Res. 2005 Jan 19;33(2):497-510
references: 15659581
references: J Biol Chem. 1998 Mar 6;273(10):5858-68
references: 9488723
references: J Hosp Infect. 2004 Jan;56(1):37-41
references: 14706269
references: Nucleic Acids Res. 2008 Feb;36(3):742-55
references: 18084033
references: Antimicrob Agents Chemother. 2012 Apr;56(4):2028-36
references: 22232292
references: Radiat Res. 2003 Jun;159(6):759-67
references: 12751958
references: Free Radic Biol Med. 2010 Mar 15;48(6):749-62
references: 20045723