title: Kindlin-2 inhibited the growth and migration of colorectal cancer cells.
abstract: Activation of Wingless (Wnt)/beta-catenin signaling is a hallmark of colorectal carcinoma (CRC). It is very important to find out the molecular mechanism for the hyperactivation of Wnt/beta-catenin signaling and identify novel therapeutic targets. Kindlin-2, a regulator of integrins, recently has been found to be involved in the tumorigenesis. However, its expression profile and functions in the progression of CRC remain poorly understood. Here, we found that the expression of Kindlin-2 was downregulated in the CRC tissues. Moreover, overexpression of Kindlin-2 in CRC cells and normal colon epithelial cells inhibited cell proliferation and migration, while downregulation of Kindlin-2 promoted the tumorigenecity of CRC cells in vitro and in vivo. Mechanistically, Kindlin-2 decreased the phosphorylation of Ser9 in glycogen synthase kinase (GSK) 3beta and promoted the ubiquitination of beta-catenin. Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of CRC.
authors: Department of Oncology, The People's Hospital of Taizhou, Taizhou, Jiangsu Province, China.
authors: Yuanyuan
authors: Y
authors: Ren
authors: Hongsong
authors: H
authors: Jin
authors: Zhidong
authors: Z
authors: Xue
authors: Qianlang
authors: Q
authors: Xu
authors: Songhua
authors: S
authors: Wang
authors: Guojun
authors: G
authors: Zhao
authors: Junxing
authors: J
authors: Huang
authors: He
authors: H
authors: Huang
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D045325:HCT116 Cells; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000235:genetics
chemical_list: C477322:FERMT3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D038362:Glycogen Synthase Kinase 3
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