title: Absolute configuration of labdane diterpenoids from Physalis nicandroides.
abstract: A mixture of the new epimeric labdenetriols 1 and 2 was isolated from the aerial parts of Physalis nicandroides. The structures of 1 and 2, including their absolute configurations, were established by analyses of their spectroscopic data, together with the X-ray diffraction analysis of acetonide 3 and chemical correlation with (-)-(13E)-labd-13-ene-8α,15-diol (6), whose absolute configuration was also confirmed by X-ray analysis of its dibromo derivative 7. The epimeric labdenediols 8 and 9, the known labdanes 6 and 11, and the acylsucroses 12 and 13 were also isolated. Labdanes 6 and 11 showed moderate anti-inflammatory activities in the induced ear edema model.
authors: Instituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., México.
authors: Emma
authors: E
authors: Maldonado
authors: Ana L
authors: AL
authors: Pérez-Castorena
authors: Yunuen
authors: Y
authors: Romero
authors: Mahinda
authors: M
authors: Martínez
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004195:Disease Models, Animal; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced; D008297:Male; D008800:Mexico; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D032321:Physalis / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes