title: Quantitative analysis of plasma proteins in whole blood-derived fresh frozen plasma prepared with three pathogen reduction technologies.
abstract: Several plasma pathogen reduction technologies (PRT) are currently available. We evaluated three plasma PRT processes: Cerus Amotosalen (AM), Terumo BCT riboflavin (RB) and Macopharma methylene blue (MB). RB treatment resulted in the shortest overall processing time and in the smallest volume loss (1%) and MB treatment in the largest volume loss (8%). MB treatment retained the highest concentrations of factors II, VII, X, IX, Protein C, and Antithrombin and the AM products of factor V and XI. Each PRT process evaluated offered distinct advantages such as procedural simplicity and volume retention (RB) and overall plasma protein retention (MB).
authors: Servicio de Fraccionamiento, Centro de Transfusión de la Comunidad Valenciana, Avenida del Cid 65, 46014 Valencia, Spain. Electronic address: larrea_lui@gva.es.
authors: Luis
authors: L
authors: Larrea
authors: Servicio de Fraccionamiento, Centro de Transfusión de la Comunidad Valenciana, Avenida del Cid 65, 46014 Valencia, Spain.
authors: María-Isabel
authors: MI
authors: Ortiz-de-Salazar
authors: Servicio de Fraccionamiento, Centro de Transfusión de la Comunidad Valenciana, Avenida del Cid 65, 46014 Valencia, Spain.
authors: Patricia
authors: P
authors: Martínez
authors: Servicio de Fraccionamiento, Centro de Transfusión de la Comunidad Valenciana, Avenida del Cid 65, 46014 Valencia, Spain.
authors: Roberto
authors: R
authors: Roig
mesh_terms: D000017:ABO Blood-Group System; D001771:Blood Banks; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D001793:Blood Preservation / Q000295:instrumentation* / Q000379:methods*; D001798:Blood Proteins / Q000737:chemistry*; D005169:Factor VIII / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D008027:Light; D008751:Methylene Blue / Q000737:chemistry; D010949:Plasma / Q000737:chemistry*; D011486:Protein C / Q000737:chemistry; D015203:Reproducibility of Results; D012256:Riboflavin / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000017:ABO Blood-Group System; D001798:Blood Proteins; D011486:Protein C; D005169:Factor VIII; D005340:Fibrinogen; D008751:Methylene Blue; D012256:Riboflavin
keywords: Coagulation factors; Pathogen reduction technology; Plasma