title: Angioplasty and stenting for severe vertebral artery orifice stenosis: effects on cerebellar function remodeling verified by blood oxygen level-dependent functional magnetic resonance imaging.
abstract: Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic resonance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treatment only. The intervention group received vertebral artery orifice angioplasty and stenting + identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.
authors: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China ; Institute of Neuroscience, Chongqing Medical University, Chongqing, China ; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, China.
authors: Bo
authors: B
authors: Liu
authors: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
authors: Zhiwei
authors: Z
authors: Li
authors: Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China ; Institute of Neuroscience, Chongqing Medical University, Chongqing, China ; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, China ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Peng
authors: P
authors: Xie
keywords: Dizziness Handicap Inventory; angioplasty and stenting; atheromatous plaque; cerebellar function remodeling; cerebral vessels; dizziness; endovascular treatment; functional magnetic resonance imaging; nerve regeneration; neural regeneration; posterior circulation ischemia; vertebral artery stenosis; vertebrobasilar insufficiency
references: J Formos Med Assoc. 2014 Sep;113(9):620-8
references: 24787662
references: J Vasc Interv Neurol. 2014 Jun;7(2):29-33
references: 25132909
references: J Comput Assist Tomogr. 2014 Sep-Oct;38(5):627-33
references: 24879456
references: PLoS One. 2012;7(9):e44556
references: 23028560
references: Exp Neurol. 2014 Nov;261:417-23
references: 25058045
references: J Stroke Cerebrovasc Dis. 2013 Oct;22(7):e234-7
references: 22974704
references: Neuroimaging Clin N Am. 1996 Aug;6(3):541-60
references: 8873092
references: Heart Dis Stroke. 1993 Nov-Dec;2(6):497-502
references: 8137057
references: Acta Neurochir (Wien). 2013 Feb;155(2):277-80
references: 23263481
references: Phytother Res. 2014 Sep;28(9):1265-74
references: 24919707
references: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jan;39(1):30-5
references: 24473383
references: Neurosci Lett. 2014 Aug 8;577:1-5
references: 24909618
references: Neuroimage. 2013 Sep;78:176-85
references: 23571420
references: Neuroradiol J. 2013 Aug;26(4):454-63
references: 24007733
references: Acta Radiol. 2012 Sep 1;53(7):802-11
references: 22850572
references: J Clin Neurosci. 2014 Feb;21(2):274-7
references: 24128770
references: J Stroke Cerebrovasc Dis. 2012 Nov;21(8):908.e7-9
references: 22365284
references: J Med Invest. 1998 Aug;45(1-4):57-70
references: 9864965
references: Zhen Ci Yan Jiu. 2013 Jun;38(3):173-80
references: 24006660
references: Curr Alzheimer Res. 2014;11(5):484-93
references: 24801219
references: Z Arztl Fortbild Qualitatssich. 1999 May;93(3):164-8
references: 10412194
references: Neurol Med Chir (Tokyo). 2010;50(2):135-8
references: 20185879
references: J Neurol. 1986 Nov;233(6):336-9
references: 2949063
references: Neural Regen Res. 2014 May 1;9(9):912-8
references: 25206911
references: J Interv Cardiol. 2004 Aug;17(4):219-32
references: 15318894
references: PLoS One. 2014 May 13;9(5):e97305
references: 24825464
references: J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23 (10 ):2598-606
references: 25280822
references: J Clin Neurophysiol. 2014 Oct;31(5):462-8
references: 25084002
references: Brain. 2009 Apr;132(Pt 4):982-8
references: 19293244
references: J Cereb Blood Flow Metab. 2014 Dec;34(12):1928-35
references: 25294127
references: J Comput Assist Tomogr. 1999 Nov-Dec;23(6):850-6
references: 10589558
references: Stroke. 2011 Oct;42(10):2795-800
references: 21852605
references: J Neuroimaging. 2013 Apr;23 (2):170-4
references: 22211776
references: Int J Mol Med. 2014 Dec;34(6):1622-8
references: 25270619
references: J Magn Reson Imaging. 2014 Oct;40(4):937-48
references: 24924449
references: Brain Topogr. 2014 Jan;27(1):123-37
references: 23990340
references: J Neurosurg. 1993 Feb;78(2):192-8
references: 8421202
references: J Vasc Surg. 2012 Apr;55(4):1167-77
references: 22206680
references: Neurosciences (Riyadh). 2012 Apr;17(2):139-44
references: 22465888
references: J Neurointerv Surg. 2012 Jul;4(4):e11
references: 21990503
references: J Spinal Cord Med. 2011;34(1):118-21
references: 21528635
references: J Vestib Res. 2013;23(6):271-7
references: 24447966
references: Neurol Med Chir (Tokyo). 1998 Jan;38(1):1-11
references: 9540326
references: BMC Neurol. 2013 Nov 11;13:171
references: 24215371
references: World J Radiol. 2012 Sep 28;4(9):391-400
references: 23024840
references: Qual Life Res. 2014 Sep;23(7):2103-7
references: 24585128
references: J Stroke Cerebrovasc Dis. 2015 Jan;24(1):163-70
references: 25294058