title: Association of CD209L tandem repeats polymorphism with susceptibility to human immunodeficiency virus-1 infection, disease progression, and treatment outcomes: a Moroccan cohort study.
abstract: In order to investigate the association between length variation of the CD209L neck region and human immunodeficiency virus (HIV)-1 susceptibility, disease progression, and treatment response outcomes, we genotyped 139 HIV-1-seropositive and 109 seronegative individuals. The heterozygous genotype 6/5 showed a significant increased risk of HIV-1 infection (OR 3.03, 95% CI 0.99-9.33, p 0.046). Moreover, after highly active antiretroviral therapy (HAART), HIV-1-seropositive individuals carrying the 6/5, 7/5 and 7/7 genotypes and alleles 5, 6 and 7 showed good CD4(+) T-cell recovery. In addition, individuals with the 7/5, 6/6 and 7/7 genotypes showed a significant decrease in viral load during the treatment period as compared with baseline (p < 0.05). Interestingly, we found that alleles 4 and 6 were associated with protection against AIDS progression. D209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression.
authors: Virology Unit, Immunovirology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
authors: N
authors: N
authors: Fayssel
authors: Laboratoire de Biochimie, Environnement & Agroalimentaire, Université Hassan II, Facultédes Sciences et Techniques, Mohammedia-Casablanca, Morocco.
authors: R
authors: R
authors: Bensghir
authors: Laboratoire de Biochimie, Environnement & Agroalimentaire, Université Hassan II, Facultédes Sciences et Techniques, Mohammedia-Casablanca, Morocco.
authors: A
authors: A
authors: Ouladlahsen
authors: Service des Maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco.
authors: H
authors: H
authors: Abdelghaffar
authors: Laboratoire de Biochimie, Environnement & Agroalimentaire, Université Hassan II, Facultédes Sciences et Techniques, Mohammedia-Casablanca, Morocco.
authors: M
authors: M
authors: Sodqi
authors: Virology Unit, Immunovirology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
authors: K
authors: K
authors: Lahlou
authors: Virology Unit, Viral Hepatitis Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco.
authors: S
authors: S
authors: Benjelloun
authors: Laboratoire de Biochimie, Environnement & Agroalimentaire, Université Hassan II, Facultédes Sciences et Techniques, Mohammedia-Casablanca, Morocco.
authors: K
authors: K
authors: Marhoum El Filali
authors: Virology Unit, Viral Hepatitis Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco. Electronic address: sayeh.ezzikouri@pasteur.ma.
authors: S
authors: S
authors: Ezzikouri
authors: Virology Unit, Immunovirology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco. Electronic address: lahcen.wakrim@pasteur.ma.
authors: L
authors: L
authors: Wakrim
mesh_terms: D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015815:Cell Adhesion Molecules / Q000235:genetics*; D015331:Cohort Studies; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009018:Morocco; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D020080:Tandem Repeat Sequences; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; C433029:CLEC4M protein, human; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface
keywords: AIDS; CD4(+); L-SIGN; tandem repeats; viral load