title: Bone marrow magnetic resonance imaging of the clivus in pediatric leukemia patients and normal controls.
abstract: OBJECTIVE
  An MRI-based pre-test to determine the probability of pediatric leukemia prior to bone marrow aspiration would be useful to prevent unnecessary exposure to this invasive test. We aimed to evaluate the clivus-to-pons signal intensity ratio (CPR) and visual scoring (VS) on T1-weighted images (T1WI) and diffusion-weighted images (DWI) to distinguish pediatric leukemia patients from normal controls.
  
  
  METHODS
  We retrospectively reviewed 1.5-T brain MR images of 13 consecutive leukemia patients (3 girls, 10 boys; mean age, 8.23 years; range, 1-17 years) and 40 age- and gender-matched normal controls. We evaluated differences between leukemia patients and normal controls using Wilcoxon rank-sum and Mann-Whitney U tests with respect to the following parameters: (1) CPR on T1WI (CPRT1WI); (2) CPR on DWI (CPRDWI); (3) VS on T1WI (VST1WI); and (4) VS on DWI (VSDWI).
  
  
  RESULTS
  The CPRT1WI values for leukemia patients and normal controls were 0.77 ± 0.12 and 1.39 ± 0.47, respectively (P < 0.001). The corresponding CPRDWI values were 1.03 ± 0.38 and 0.50 ± 0.17, respectively (P < 0.001). VST1WI and VSDWI were significantly different between the groups (P < 0.001 for both).
  
  
  CONCLUSIONS
  MRI-based quantitative and qualitative analyses of clival bone marrow on T1WI and DWI can distinguish pediatric leukemia patients from normal subjects.
authors: Department of Radiology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Hyogo, Japan, ttsynishii@gmail.com.
authors: Tatsuya
authors: T
authors: Nishii
authors: Atsushi K
authors: AK
authors: Kono
authors: Yoshinobu
authors: Y
authors: Akasaka
authors: Takeshi
authors: T
authors: Mori
authors: Akira
authors: A
authors: Hayakawa
authors: Kazumoto
authors: K
authors: Iijima
authors: Kazuro
authors: K
authors: Sugimura
mesh_terms: D000293:Adolescent; D001853:Bone Marrow; D002648:Child; D002675:Child, Preschool; D003388:Cranial Fossa, Posterior; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia; D008279:Magnetic Resonance Imaging; D008297:Male; D011149:Pons; D012189:Retrospective Studies
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