title: Serum 25-hydroxy vitamin D and survival in advanced colorectal cancer: a retrospective analysis.
abstract: Higher serum 25-hydroxy vitamin D [25(OH)D] levels are associated with decreased colorectal cancer (CRC) incidence. In this retrospective study of Stage IV CRC patients, we evaluate whether 25(OH)D levels at diagnosis correlate with survival. Stored sera from carcinoembryonic antigen (CEA) measurements obtained between February 2005 and March 2006 were screened. The first 250 patients with CEA ± 30 days of Stage IV CRC diagnosis were included. Serum 25(OH)D levels were determined and categorized as adequate ≥ 30 ng/mL, or deficient <30 ng/mL. Multivariable Cox regression models controlling for albumin and Eastern Cooperative Oncology Group performance status were used to investigate whether higher 25(OH)D levels were associated with prolonged survival. A total of 207 patients (83%) were vitamin D-deficient (median = 21 ng/mL), with deficiencies significantly more likely among non-Hispanic black patients (P = 0.009). Higher levels were associated with prolonged survival in categorical variable analysis: adequate vs. deficient, hazard ratio = 0.61, 95% confidence interval = 0.38-0.98, P = 0.041. A majority of newly diagnosed Stage IV CRC patients are vitamin D-deficient. Our data suggest that higher 25(OH)D levels are associated with better overall survival. Clinical trials to determine whether aggressive vitamin D repletion would improve outcomes for vitamin D-deficient CRC patients are warranted.
authors: a Memorial Sloan Kettering Cancer Center, Integrative Medicine Service , New York , New York , USA.
authors: Kathleen M
authors: KM
authors: Wesa
authors: Neil H
authors: NH
authors: Segal
authors: Angel M
authors: AM
authors: Cronin
authors: Daniel D
authors: DD
authors: Sjoberg
authors: Gria N
authors: GN
authors: Jacobs
authors: Marci I
authors: MI
authors: Coleton
authors: Martin
authors: M
authors: Fleisher
authors: Ann M
authors: AM
authors: Dnistrian
authors: Leonard B
authors: LB
authors: Saltz
authors: Barrie R
authors: BR
authors: Cassileth
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality; D006801:Humans; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
references: Cancer Res. 1997 Sep 1;57(17):3759-64
references: 9288784
references: Clin Cancer Res. 1999 Mar;5(3):695-703
references: 10100724
references: Altern Med Rev. 2005 Jun;10(2):94-111
references: 15989379
references: J Nutr. 2005 Oct;135(10):2350-4
references: 16177194
references: Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2370-6
references: 16214919
references: J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):179-94
references: 16236494
references: Anticancer Res. 2006 Jul-Aug;26(4A):2669-81
references: 16886677
references: Anticancer Res. 2006 Jul-Aug;26(4A):2729-33
references: 16886684
references: Nutr Cancer. 2006;55(1):35-43
references: 16965239
references: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2467-72
references: 17132768
references: Am J Prev Med. 2007 Mar;32(3):210-6
references: 17296473
references: J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):763-7
references: 17257827
references: Arch Intern Med. 2007 Jun 11;167(11):1159-65
references: 17563024
references: J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9
references: 17623801
references: Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2752-5
references: 18086783
references: J Bone Miner Res. 2007 Dec;22 Suppl 2:V81-5
references: 18290728
references: J Clin Oncol. 2008 Jun 20;26(18):2984-91
references: 18565885
references: Mol Aspects Med. 2008 Dec;29(6):361-8
references: 18801384
references: J Am Coll Cardiol. 2008 Dec 9;52(24):1949-56
references: 19055985
references: Int J Colorectal Dis. 2009 Feb;24(2):219-24
references: 18830610
references: Ann Epidemiol. 2009 Feb;19(2):84-8
references: 18291673
references: J Clin Oncol. 2009 Aug 10;27(23):3757-63
references: 19451439
references: Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2765-72
references: 19789368
references: J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):349-54
references: 20398758
references: BMC Cancer. 2010;10:347
references: 20594355
references: J Clin Endocrinol Metab. 2011 Jan;96(1):53-8
references: 21118827
references: Annu Rev Pharmacol Toxicol. 2011;51:311-36
references: 20936945
references: J Bone Miner Res. 2011 Mar;26(3):455-7
references: 21337617
references: Cancer. 2011 Mar 1;117(5):1061-9
references: 20945439
references: J Clin Oncol. 2011 Apr 20;29(12):1599-606
references: 21422438
references: Cancer Prev Res (Phila). 2011 May;4(5):735-43
references: 21430073
references: Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):1003-16
references: 21378269
references: Nutr J. 2011;10:51
references: 21575232
references: J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
references: 21646368
references: Ann Surg Oncol. 2012 Aug;19(8):2590-9
references: 22446898
references: Anticancer Agents Med Chem. 2013 Jan;13(1):11-9
references: 23094917
references: Anticancer Res. 2013 Feb;33(2):433-44
references: 23393334
references: Horm Cancer. 2013 Aug;4(4):242-50
references: 23456391
references: Breast Cancer Res Treat. 2013 Oct;141(3):331-9
references: 24104883
references: Nat Rev Cancer. 2014 May;14(5):342-57
references: 24705652
references: Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):113-9
references: 11815408
references: Mol Cancer Ther. 2002 Aug;1(10):821-9
references: 12492115