title: Faldaprevir for the treatment of genotype-1 hepatitis C virus.
abstract: Historically, pegylated interferon in combination with ribavirin was the standard of care in hepatitis C virus; however, this combination is often poorly tolerated, has a significant side-effect profile and is of limited efficacy in hepatitis C virus genotype-1. More recently, pegylated interferon/ribavirin has been combined with direct acting antiviral agents such as the first generation NS3/4A protease inhibitors. Faldaprevir, a first generation, second-wave protease inhibitor, when used with a pegylated interferon/ribavirin regimen, has also been shown to increase treatmentsuccess while shortening treatment duration; however, second generation direct acting antiviral agents offer even betterefficacy and tolerability. Various direct acting antiviral agent combinations in interferon-free regimens have been effective in over 95% of patients and are now in licensed use. While faldaprevir was a pioneering drug, by the time it reached late phase development it was superseded by newer agents.
authors: Kings College Hospital, Institute for liver studies, London, UK.
authors: Kosh
authors: K
authors: Agarwal
authors: Ashley
authors: A
authors: Barnabas
mesh_terms: D000621:Aminoisobutyric Acids; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007930:Leucine / Q000031:analogs & derivatives; D009842:Oligopeptides / Q000009:adverse effects / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives; D011480:Protease Inhibitors / Q000627:therapeutic use; D011804:Quinolines; D012254:Ribavirin / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000621:Aminoisobutyric Acids; D000998:Antiviral Agents; D009842:Oligopeptides; D011480:Protease Inhibitors; D011804:Quinolines; D013844:Thiazoles; D011092:Polyethylene Glycols; D012254:Ribavirin; D007372:Interferons; C552340:faldaprevir; D011392:Proline; D007930:Leucine
keywords: boceprevir; faldaprevir; hepatitis C; liver transplantation; pegylated interferon; ribavirin; simeprevir; telaprevir