title: Comparative effects of retinoic acid or glycolic acid vehiculated in different topical formulations.
abstract: Retinoids and hydroxy acids have been widely used due to their effects in the regulation of growth and in the differentiation of epithelial cells. However, besides their similar indication, they have different mechanisms of action and thus they may have different effects on the skin; in addition, since the topical formulation efficiency depends on vehicle characteristics, the ingredients of the formulation could alter their effects. Thus the objective of this study was to compare the effects of retinoic acid (RA) and glycolic acid (GA) treatment on the hairless mouse epidermis thickness and horny layer renewal when added in gel, gel cream, or cream formulations. For this, gel, gel cream, and cream formulations (with or without 6% GA or 0.05% RA) were applied in the dorsum of hairless mice, once a day for seven days. After that, the skin was analyzed by histopathologic, morphometric, and stereologic techniques. It was observed that the effects of RA occurred independently from the vehicle, while GA had better results when added in the gel cream and cream. Retinoic acid was more effective when compared to glycolic acid, mainly in the cell renewal and the exfoliation process because it decreased the horny layer thickness.
authors: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil.
authors: Patrícia Maria Berardo Gonçalves
authors: PM
authors: Maia Campos
authors: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil.
authors: Lorena Rigo
authors: LR
authors: Gaspar
authors: Faculdade de Ciências Farmacêuticas, Pontifícia Universidade Católica de Campinas, 13060-904 Campinas, SP, Brazil.
authors: Gisele Mara Silva
authors: GM
authors: Gonçalves
authors: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, 14040-903 Ribeirão Preto, SP, Brazil.
authors: Lúcia Helena Terenciane Rodrigues
authors: LH
authors: Pereira
authors: Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Marisa
authors: M
authors: Semprini
authors: Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Ruberval Armando
authors: RA
authors: Lopes
mesh_terms: D000287:Administration, Topical; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004848:Epithelium / Q000187:drug effects; D006016:Glycolates / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008812:Mice, Hairless; D012867:Skin / Q000166:cytology / Q000187:drug effects; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D006016:Glycolates; C031149:glycolic acid; D014212:Tretinoin
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