title: Catalytic asymmetric Henry reaction of nitroalkanes and aldehydes catalyzed by a chiral N,N'-dioxide/Cu(I) complex.
abstract: An easily available N,N'-dioxide/Cu(I) complex has been developed for the catalytic asymmetric nitroaldol (Henry) reaction of aldehydes with nitroethane. Under mild reaction conditions, a series of substituted aromatic, heteroaromatic and α,β-unsaturated aldehydes are transformed to the corresponding anti-β-nitroalcohols in good to excellent yields (up to 99%) with moderate to good dr (up to 16.7:1 anti/syn) and high ee values (up to 97%). Besides nitroethane, nitromethane and 1-nitropropane were also employed as nucleophiles, and good enantioselectivities were obtained.
authors: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, People's Republic of China.
authors: Hongjiang
authors: H
authors: Mei
authors: Xiao
authors: X
authors: Xiao
authors: Xiaohu
authors: X
authors: Zhao
authors: Bing
authors: B
authors: Fang
authors: Xiaohua
authors: X
authors: Liu
authors: Lili
authors: L
authors: Lin
authors: Xiaoming
authors: X
authors: Feng