title: Selective ion exchange governed by the Irving-Williams series in K2Zn3[Fe(CN)6]2 nanoparticles: toward a designer prodrug for Wilson's disease.
abstract: The principle of the Irving-Williams series is applied to the design of a novel prodrug based on K2Zn3[Fe(CN)6]2 nanoparticles (ZnPB NPs) for Wilson's disease (WD), a rare but fatal genetic disorder characterized by the accumulation of excess copper in the liver and other vital organs. The predetermined ion-exchange reaction rather than chelation between ZnPB NPs and copper ions leads to high selectivity of such NPs for copper in the presence of the other endogenous metal ions. Furthermore, ZnPB NPs are highly water-dispersible and noncytotoxic and can be readily internalized by cells to target intracellular copper ions for selective copper detoxification, suggesting their potential application as a new-generation treatment for WD.
authors: Department of Chemistry and Biochemistry, Kent State University , Kent, Ohio 44240, United States.
authors: Murthi S
authors: MS
authors: Kandanapitiye
authors: Fan Jennifer
authors: FJ
authors: Wang
authors: Benjamin
authors: B
authors: Valley
authors: Chamila
authors: C
authors: Gunathilake
authors: Mietek
authors: M
authors: Jaroniec
authors: Songping D
authors: SD
authors: Huang
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003300:Copper / Q000378:metabolism; D005295:Ferrocyanides / Q000737:chemistry; D006367:HeLa Cells; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007477:Ions / Q000737:chemistry; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011188:Potassium / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D013499:Surface Properties; D015032:Zinc / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D005295:Ferrocyanides; D007477:Ions; D011355:Prodrugs; D003300:Copper; D015032:Zinc; D011188:Potassium