title: An efficient synthesis method targeted to marine alkaloids marinacarbolines A-D and their antitumor activities.
abstract: Marinacarbolines A-D are a series of marine β-carboline alkaloids isolated from actinomycete Marinactinospora thermotolerans of the deep South China Sea with antiplasmodial activities. In inhibition assays of in vitro growth of Plasmodium falciparum, marinacarbolines exhibited antiplasmodial activity against drug-sensitive line 3D7 and drug-resistant line Dd2 of P. falciparum. However, approaches for the synthesis of such useful compounds are very limited. In this work, we reported a simple, efficient, and versatile process to synthesize marinacarbolines A-D (1-4). On the basis of that, the antitumor activities of marinacarbolines in a structure-dependent manner were allowed to be unveiled.
authors: a Key Laboratory of Marine Drugs , Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003 , China.
authors: Jun
authors: J
authors: Li
authors: Yang
authors: Y
authors: Tang
authors: Hui-Juan
authors: HJ
authors: Jin
authors: Yi-Di
authors: YD
authors: Cui
authors: Li-Juan
authors: LJ
authors: Zhang
authors: Tao
authors: T
authors: Jiang
mesh_terms: D000190:Actinomyces / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D008386:Marine Biology; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000970:Antineoplastic Agents; D010936:Plant Extracts
keywords: antitumor activities; marinacarbolines; marine β-carboline alkaloid; synthesis