title: Mitochondrial donation--how many women could benefit?
abstract: Mitochondrial disease is maternally inherited and refractory to treatment, but assisted reproduction methods can result in unaffected pregnancies. The authors provide estimates of the number of affected pregnancies per year in the United Kingdom and the United States.
authors: Newcastle University Newcastle upon Tyne, United Kingdom doug.turnbull@newcastle.ac.uk.
authors: Gráinne S
authors: GS
authors: Gorman
authors: Newcastle University Newcastle upon Tyne, United Kingdom doug.turnbull@newcastle.ac.uk.
authors: John P
authors: JP
authors: Grady
authors: Newcastle University Newcastle upon Tyne, United Kingdom doug.turnbull@newcastle.ac.uk.
authors: Doug M
authors: DM
authors: Turnbull
mesh_terms: D000293:Adolescent; D000328:Adult; D001723:Birth Rate; D004272:DNA, Mitochondrial; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000331:legislation & jurisprudence*; D033161:Government Regulation; D006801:Humans; D008928:Mitochondria / Q000637:transplantation*; D028361:Mitochondrial Diseases / Q000235:genetics*; D009154:Mutation; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial
references: Nature. 2010 May 6;465(7294):82-5
references: 20393463
references: Nature. 2009 Sep 17;461(7262):367-72
references: 19710649