title: [Cognitive Function and Calcium. The relationship between inositol phosphates and brain function].
abstract: Inositol phosphates are produced depending on the numbers of the phosphate group which is added to the inositol ring which is 6 membered ring derived from a component of a biological membrane. Inositol 1, 4, 5 trisphosphate (IP3) operates on IP3 receptor on the endoplasmic reticulum, and is related to a release of calcium in the cell. IP3 is associated with various brain functions and neurodegenerative disorders. Moreover, there are IP4, IP5, IP6 and IP7 such as inositol polyphosphates in mammals. Notably, inositol hexakisphoshate kinase (IP6) which phosphorylates IP6 to IP7 plays important roles in the pathophysiology of various neurodegenerative disorders.
authors: Department of Neurology, Tokai University School of Medicine, Japan.
authors: Eiichiro
authors: E
authors: Nagata
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*
chemical_list: D002136:Calcium, Dietary; D007295:Inositol Phosphates; D002118:Calcium