title: MiR-210 links hypoxia with cell proliferation regulation in human Laryngocarcinoma cancer.
abstract: The microRNA hsa-miR-210 (miR-210) is associated with hypoxia; however its function has not fully identified. In the present study, we aim to detect its role concerning proliferation in Laryngocarcinoma. We found that miR-210 was highly expressed in hypoxia, which inhibited proliferation by inducing cell cycle arrest in G1/G0 as well as apoptosis. We further identified that miR-210 targeted fibroblast growth factor receptor-like 1 (FGFRL1). Down regulation of FGFRL1 decreased cell proliferation by promoting proportion of cells in G1/G0 phase and decreasing in S and G2/M phases. Moreover, overexpression of FGFRL1 effectively released the miR-210-induced suppression of SCC10A cell proliferation. Expression of miR-210 repressed tumor xenograft growth in vivo as well. Together, our findings reveal a new mechanism of adaptation to hypoxia that miR-210 inhibits the proliferation via inducing cell cycle arrest and apoptosis by the targeting of FGFRL1. J. Cell. Biochem. 116: 1039-1049, 2015. © 2015 Wiley Periodicals, Inc.
authors: State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518060, China; The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, 421001, China; School of Medicine, University of South China, Hengyang, Hunan, 421001, China.
authors: Jianhong
authors: J
authors: Zuo
authors: Meiling
authors: M
authors: Wen
authors: Mingsheng
authors: M
authors: Lei
authors: Xiang
authors: X
authors: Peng
authors: Xuefeng
authors: X
authors: Yang
authors: Zhigang
authors: Z
authors: Liu
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs
keywords: CELL PROLIFERATION; FGFRL1; HYPOXIA; LARYNGOCARCINOMA CANCER; MiR-210