title: Recurrent HLA-B56 mediated neonatal alloimmune thrombocytopenia with fatal outcomes.
abstract: Neonatal alloimmune thrombocytopenia is caused by maternal antibodies against paternally-inherited alloantigens present on foetal platelets and is a significant cause of morbidity and mortality in neonates. While generally thought of as a human platelet antibody mediated phenomenon, cases of HLA mediated NAIT have been reported. We document the investigation of a patient with two pregnancies affected by HLA-B56 mediated NAIT and a proposal for management of future pregnancies.
authors: Australian Red Cross Blood Service, Sydney, Australia. Electronic address: anna.ostberg@gmail.com.
authors: Anna L
authors: AL
authors: Hutchinson
authors: Australian Red Cross Blood Service, Sydney, Australia.
authors: Peta M
authors: PM
authors: Dennington
authors: Australian Red Cross Blood Service, Sydney, Australia.
authors: Rhonda
authors: R
authors: Holdsworth
authors: Nepean Hospital, Sydney, Australia.
authors: Lyn
authors: L
authors: Downe
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D005313:Fetal Death; D015235:HLA-B Antigens / Q000737:chemistry*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D010375:Pedigree; D012008:Recurrence; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood* / Q000276:immunology
chemical_list: D016824:Antigens, Human Platelet; D015235:HLA-B Antigens; C056079:HLA-B56 antigen; D007518:Isoantibodies
keywords: Alloimmune; Fetomaternal; HLA; Neonatal; Thrombocytopenia