title: Application of Low-Level Laser Therapy Following Coronary Artery Bypass Grafting (CABG) Surgery.
abstract: BACKGROUND
  An attack of acute myocardial infarction (MI) poses the threat of great damage to cardiac tissue. Operative therapeutic modalities such as coronary artery bypass grafting (CABG) may enhance myocardial perfusion in high-grade coronary vasculature occlusions. It has been shown previously that Low-Level Laser Therapy (LLLT) significantly reduces infarct size following induction of myocardial infarction in rats and dogs. The aim of this study was to investigate the effects of LLLT on cardiac tissue healing markers following grafting operations for coronary vessel occlusion.
  
  
  METHODS
  Thirty-two cases having each two or three coronary vessel occlusions (2VD/3VD) underwent low-level laser therapy post-CABG, and 28 patients who did not undergo laser therapy were studied as a control group. Diode laser (810 nm, 500 mW) was used as LLLT protocol for 3 successive days post-CABG. Repeated measurements of blood cell count (CBC) and cardiac damage markers (CPK, CPK-MB, LDH) attained before CABG and during the 5 days of LLLT post-operatively, taken at one and 12 hours after daily laser irradiation.
  
  
  RESULTS
  In a comparison of the mean levels of the control and laser group, the variables were statistically different on 5(th) day after intervention for WBC, Neutrophil and Lymphocyte counts and WBC and lymphocyte changes. A statistically significant difference was seen in changes of CPK, CPK-mb and LDH over time P<0.001.
  
  
  CONCLUSIONS
  It is concluded that low-level laser irradiation after CABG surgery could decrease cardiac cellular damage and help accelerate the repair of cardiac tissue post-operatively. This may lower post-operative disability as well as bed rest period in these patients.
authors: Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.
authors: Nooshafarin
authors: N
authors: Kazemi Khoo
authors: Department of Surgery, Milad General Hospital, Tehran, Iran.
authors: Kamran
authors: K
authors: Babazadeh
authors: Department of Laser, Milad Hospital, Tehran, Iran.
authors: Marjan
authors: M
authors: Lajevardi
authors: Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors: Fataneh Hashem
authors: FH
authors: Dabaghian
authors: Department of Epidemiology, Pasteur Institute of Iran, Tehran, Iran.
authors: Ehsan
authors: E
authors: Mostafavi
keywords: coronary artery bypass; heart disease; low level laser therapy
references: Lasers Surg Med. 2001;28(4):355-64
references: 11344517
references: Lasers Surg Med. 2001;28(3):212-5
references: 11295754
references: J Appl Physiol (1985). 2001 Jun;90(6):2411-9
references: 11356808
references: Circ Res. 1988 Sep;63(3):543-9
references: 3409486
references: Circ Res. 1998 Feb 9;82(2):166-74
references: 9468187
references: Lasers Surg Med. 1998;22(5):294-301
references: 9671996
references: Circulation. 2001 Jan 16;103(2):296-301
references: 11208692
references: Plast Reconstr Surg. 1996 Mar;97(3):555-8; discussion 559
references: 8596786
references: Tex Heart Inst J. 1989;16(3):141-9
references: 15227198
references: Kardiol Pol. 2007 Jan;65(1):13-21; discussion 22-3
references: 17295156
references: Anat Rec. 1993 Mar;235(3):374-80
references: 8430907
references: Photochem Photobiol. 1997 Dec;66(6):866-71
references: 9421973
references: Biochim Biophys Acta. 2003 Feb 17;1593(2-3):131-9
references: 12581857
references: Lasers Surg Med. 1998;22(4):212-8
references: 9603282
references: Surgery. 1953 Jan;33(1):52-9
references: 13015312
references: Ann N Y Acad Sci. 2005 Nov;1056:486-93
references: 16387711
references: Lasers Surg Med. 2000;27(1):29-38
references: 10918290
references: Kardiologiia. 1990 Apr;30(4):44-7
references: 2395262
references: Acta Orthop Scand. 1991 Aug;62(4):386-7
references: 1882683
references: Ann Surg. 1910 Jul;52(1):83-95
references: 17862563
references: Lasers Surg Med. 1998;22(5):281-7
references: 9671994
references: Lasers Surg Med. 1997;20(3):332-9
references: 9138262
references: Lasers Surg Med. 2002;31(4):283-8
references: 12355575
references: Przegl Lek. 2004;61(1):35-8
references: 15230104
references: Antioxid Redox Signal. 2002 Oct;4(5):783-4
references: 12470505
references: Lasers Surg Med. 1999;24(2):133-41
references: 10100651
references: Stroke. 2004 Aug;35(8):1985-8
references: 15155955
references: Angiology. 1990 Sep;41(9 Pt 2):801-8
references: 2221480
references: Vopr Kurortol Fizioter Lech Fiz Kult. 2003 Jul-Aug;(4):10-3
references: 12945135
references: Anat Embryol (Berl). 1994 Dec;190(6):597-602
references: 7534455
references: Int J Cardiol. 2001 Sep-Oct;80(2-3):109-16
references: 11578700