title: A new look at osteomyelitis development--focus on CCR5delta32. Study in patients from Northeast Brazil.
abstract: BACKGROUND
  CCR5 receptor exerts an important role in the host immune response. Osteomyelitis is an inflammatory process and Staphylococcus aureus is the principal causative agent of this bone injury complication. A deletion of 32bp (CCR5Δ32) in the CCR5 gene seems to protect against HIV-1, S.aureus and other infections. However, the CCR5Δ32 allele has been associated with an increased risk for other diseases.
  
  
  OBJECTIVE
  To investigate the function of CCR5 and to gather data about the relationship of the CCR5Δ32 mutation and the risk of developing osteomyelitis as a complication in patients with bone traumas.
  
  
  METHODS
  In a study of 153 patients with bone traumas the presence of the CCRΔ32 mutation was determined by PCR.
  
  
  RESULTS
  In this study, the CCR5Δ32 allele was present only in the heterozygous form. Osteomyelitis was more frequent in the wild type carriers (94.87%; 37/39) and most of the CCR5Δ32 carriers (87.5%; 14/16) did not present with osteomyelitis.
  
  
  CONCLUSIONS
  The CCR5Δ32 could be associated with protection against osteomyelitis caused by S. aureus, corroborating the data from Alonzo & Torres study, in which CCR5 receptor is required for S. aureus leukotoxin ED (LukED) cytotoxicity.
authors: Universidade Federal do Ceará, Fortaleza, Ceará, Brazil; Instituto Dr. José Frota, Fortaleza, Ceará, Brazil.
authors: Maria do Socorro Queiroz Alves
authors: Mdo S
authors: de Souza
authors: Instituto Dr. José Frota, Fortaleza, Ceará, Brazil.
authors: Clinio Alves
authors: CA
authors: de Souza
authors: Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors: Lia Moreira Pinto
authors: LM
authors: Cunha
authors: Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors: Argos Queiroz Alves
authors: AQ
authors: de Souza
authors: Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors: Maíra Silva
authors: MS
authors: de Morais
authors: Universidade Federal do Ceará, Fortaleza, Ceará, Brazil. Electronic address: srabenhorst@hotmail.com.
authors: Sílvia Helena Barem
authors: SH
authors: Rabenhorst
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001938:Brazil; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D010019:Osteomyelitis / Q000209:etiology* / Q000276:immunology; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5
keywords: CCR5; CCR5Δ32; Osteomyelitis; Staphylococcus aureus