title: Effect of submucosal fibrosis on endoscopic submucosal dissection of colorectal tumors: pathologic review of 173 cases.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) is now commonly performed as a treatment for colorectal tumors. However, little is known about the relationship between submucosal fibrosis and the outcome of the colonic ESD procedure. The aims of this study were to investigate the relationship between the degree of submucosal fibrosis in colorectal tumors and the outcomes of ESD for these tumors and to evaluate the risk factors for submucosal fibrosis.
  
  
  METHODS
  We retrospectively reviewed the records of patients with colorectal adenoma or carcinoma who had undergone an ESD, during a four-year period from January 2010 to December 2013. The resected specimens were histologically examined after Masson's trichrome staining, and the severity of the submucosal fibrosis was classified as no fibrosis (F0), mild fibrosis (F1), or severe fibrosis (F2).
  
  
  RESULTS
  Among a total of 173 cases (106 male, mean age 65.0 ± 10.2 years; F0 33, F1 78, F2 62) enrolled, 46 incidences of complications (perforation 19, post-coagulation syndrome 21, bleeding 6) had developed. Multivariate analysis revealed that F2 fibrosis was significantly associated with the development of complications. Submucosal invasion and large tumor size (≥ 30 mm) were identified as independent predictors of F2 fibrosis.
  
  
  CONCLUSIONS
  Severe fibrosis is the most powerful risk factor for complications and can interfere with en bloc resections. The possibility of submucosal fibrosis should be considered, and the procedure should be cautiously performed in cases where the tumor diameter is greater than 30 mm and when submucosal cancer is suspected.
authors: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors: Sang Pyo
authors: SP
authors: Lee
authors: Jeong Hwan
authors: JH
authors: Kim
authors: In-Kyung
authors: IK
authors: Sung
authors: Sun-Young
authors: SY
authors: Lee
authors: Hyung Seok
authors: HS
authors: Park
authors: Chan Sup
authors: CS
authors: Shim
authors: Hye Seung
authors: HS
authors: Han
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: colorectal tumor; endoscopic submucosal dissection; submucosal fibrosis