title: Relation between birth weight, growth, and subclinical atherosclerosis in adulthood.
abstract: OBJECTIVE
  Adverse conditions in the prenatal environment and in the first years of life are independently associated with increased risk for cardiovascular disease. This paper aims to study the relation between birthweight, growth in the first year of life, and subclinical atherosclerosis in adults.
  
  
  METHODS
  88 adults aged between 20 and 31 were submitted to sociodemographic qualities, anthropometric data, blood pressure measurements, metabolic profile, and evaluation of subclinical atherosclerosis.
  
  
  RESULTS
  Birthweight<2,500 grams (g) was negatively correlated with (a) increased waist-to-hip ratio (WHR), according to regression coefficient (RC) equal to -0.323, 95% CI [-0.571, -0.075] P<0.05; (b) diastolic blood pressure (RC=-4.744, 95% CI [-9.017, -0.470] P<0.05); (c) low HDL-cholesterol (RC=-0.272, 95% CI [-0.516, -0.029] P<0.05); (d) frequency of intima-media thickness (IMT) of left carotid>75th percentile (RC=-0.242, 95% CI [-0.476, -0.008] P<0.05). Birthweight>3,500 g was associated with (a) BMI>25.0 kg/m2, (RC=0.317, 95% CI [0.782, 0.557] P<0.05); (b) increased waist circumference (RC=0.284, 95% CI [0.054, 0.513] P<0.05); (c) elevated WHR (RC=0.280, 95% CI [0.054, 0.505] P<0.05); (d) minimum subcutaneous adipose tissue (SAT) (RC=4.354, 95% CI [0.821, 7.888] P<0.05); (e) maximum SAT (RC=7.095, 95% CI [0.608, 13.583] P<0.05); (f) right lobe of the liver side (RC=6.896, 95% CI [1.946, 11.847] P<0.001); (g) frequency's right lobe of the liver>75th percentile (RC=0.361, 95% CI [0.169, 0.552] P<0.001). Weight gain in the first year of life was inversely correlated with (a) mean IMT of left carotid (RC=-0.046, 95% CI [-0.086, -0.006] P<0.05; (b) frequency IMT of left carotid>75th percentile (RC=-0.253, 95% CI [-0.487, -0.018] P<0.05); (c) mean IMT (RC=-0.038, 95% CI [0.073, -0.002] P<0.05); (d) the frequency of the mean IMT>75th percentile (RC=-0.241, 95% CI [-0.442, -0.041] P<0.05).
  
  
  CONCLUSIONS
  Adults birthweight<2,500 g and >3,500 g and with insufficient weight gain in the first year of life have showed different metabolic phenotypes, but all of them were related to subclinical atherosclerosis.
authors: Department of Pediatrics, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Maria Helena
authors: MH
authors: Valente
authors: Department of Pediatrics, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Filumena Maria
authors: FM
authors: da Silva Gomes
authors: Department of Clinical Medicine, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Isabela Judith Martins
authors: IJ
authors: Benseñor
authors: Department of Pediatrics, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Alexandra Valéria Maria
authors: AV
authors: Brentani
authors: Department of Pediatrics, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Ana Maria
authors: AM
authors: de Ulhôa Escobar
authors: Department of Pediatrics, Medical School, University of São Paulo (USP), 01246-903 São Paulo, SP, Brazil.
authors: Sandra J F E
authors: SJ
authors: Grisi
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology*; D001724:Birth Weight / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D015430:Weight Gain; D055815:Young Adult
references: Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S99-105
references: 23035149
references: PLoS One. 2012;7(10):e47776
references: 23082214
references: BMC Pregnancy Childbirth. 2013;13:38
references: 23409828
references: BMJ. 1998 Jul 25;317(7153):241-5
references: 9677213
references: Lancet. 2011 Jun 4;377(9781):1949-61
references: 21561658
references: Stroke. 2007 Feb;38(2):264-70
references: 17218608
references: JAMA. 2004 Dec 8;292(22):2755-64
references: 15585736
references: Hypertension. 2003 Dec;42(6):1206-52
references: 14656957
references: Obesity (Silver Spring). 2007 Jun;15(6):1600-8
references: 17557998
references: Obes Rev. 2007 Mar;8 Suppl 1:45-9
references: 17316301
references: BMJ. 1993 Dec 11;307(6918):1524-7
references: 8274921
references: Nutr Hosp. 2011 Sep-Oct;26(5):971-6
references: 22072340
references: J Intensive Care Med. 2004 Nov-Dec;19(6):307-19
references: 15523117
references: Int J Obes (Lond). 2007 Oct;31(10):1534-44
references: 17653070
references: BMC Public Health. 2010;10:484
references: 20712860
references: J Hypertens. 2011 Dec;29(12):2324-31
references: 22025237
references: J Dev Orig Health Dis. 2010 Dec;1(6):403-11
references: 22318657
references: Diabetes Care. 2010 Jan;33 Suppl 1:S62-9
references: 20042775
references: Kardiol Pol. 2011;69(7):673-8
references: 21769785
references: Am J Clin Nutr. 2010 Aug;92(2):347-52
references: 20519560
references: Lancet. 2005 Apr 23-29;365(9469):1484-6
references: 15850633
references: Med Pregl. 2012 Nov-Dec;65(11-12):483-8
references: 23297614
references: Eur J Endocrinol. 2006 Oct;155(4):601-7
references: 16990660
references: BMJ. 2001 Apr 21;322(7292):949-53
references: 11312225
references: Am J Clin Nutr. 2001 Jan;73(1):123-6
references: 11124761
references: Lancet. 1986 May 10;1(8489):1077-81
references: 2871345
references: Atherosclerosis. 2002 Jul;163(1):141-7
references: 12048132
references: Rev Endocr Metab Disord. 2012 Jun;13(2):121-7
references: 22415298
references: BMJ. 1993 Dec 11;307(6918):1519-24
references: 8274920
references: JAMA. 1998 Dec 2;280(21):1843-8
references: 9846779
references: Science. 2004 Sep 17;305(5691):1733-6
references: 15375258
references: Hypertension. 2004 Dec;44(6):838-46
references: 15520301
references: Paediatr Perinat Epidemiol. 2008 Jan;22(1):12-21
references: 18173779
references: Circulation. 2005 Oct 25;112(17):2735-52
references: 16157765
references: Int J Obes Relat Metab Disord. 2003 Feb;27(2):173-80
references: 12586996
references: Circulation. 2004 Jul 13;110(2):227-39
references: 15249516
references: Swiss Med Wkly. 2012;142:w13705
references: 23135891
references: N Engl J Med. 2005 Oct 27;353(17):1802-9
references: 16251536
references: Int J Epidemiol. 2003 Oct;32(5):862-76
references: 14559765
references: Obes Rev. 2011 Jul;12(7):525-42
references: 21438992
references: Circulation. 2005 Nov 15;112(20):3184-209
references: 16286609
references: Am J Epidemiol. 2007 Apr 15;165(8):849-57
references: 17215379