title: Sacroplasty for cancer-associated insufficiency fractures.
abstract: BACKGROUND
  Tumor-associated sacral insufficiency fractures (SIF) present a significant clinical challenge. As survival increases for many malignancies, sacral fractures associated with metastases, sacral or extended pelvic radiation, and paraneoplastic osteoporosis are increasingly common and yet remain difficult to treat in the setting of the potentially significant morbidity of open sacral surgery.
  
  
  OBJECTIVE
  To describe our prospective experience with sacroplasty for tumor-associated lesions, including the largest series to date of radiation-induced SIF.
  
  
  METHODS
  Twenty-five patients with symptomatic SIF underwent 31 percutaneous fluoroscopy-guided sacroplasties with a median 5.8 mL of polymethyl methacrylate or a ceramic-resin composite under fluoroscopic guidance and with concurrent biopsy acquisition. Eighteen patients had fractures related to previous sacral or pelvic radiation; 4 had viable lytic lesions; and 2 had oncology-related osteoporosis. Postoperative pain reduction, procedural morbidity, and functional outcomes were recorded.
  
  
  RESULTS
  Twenty of 25 patients (80%) had reduction in their visual analog pain score at a median follow-up of 6.5 months; no patients worsened. The mean visual analog scale score decreased from 8.8 to 4.7 postprocedurally (P < .001), with significant reductions regardless of the underlying pathology (P < .001 to P < .05). Six of 13 patients with pretreatment ambulatory impairment required fewer ambulatory aids and 3 were newly ambulatory. Extravertebral cement migration was noted in 18 procedures; however, no instance was clinically relevant. Six repeat or contralateral procedures were performed. No morbidity was encountered.
  
  
  CONCLUSIONS
  Sacroplasty is a safe and effective option for the palliation of sacral fractures in the oncologic population.
authors: *Division of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; ‡Department of Neurological Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York; §Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; ¶Division of Orthopedic Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
authors: Nelson
authors: N
authors: Moussazadeh
authors: Ilya
authors: I
authors: Laufer
authors: Timothy
authors: T
authors: Werner
authors: George
authors: G
authors: Krol
authors: Patrick
authors: P
authors: Boland
authors: Mark H
authors: MH
authors: Bilsky
authors: Eric
authors: E
authors: Lis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements / Q000627:therapeutic use*; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D015775:Fractures, Stress / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010147:Pain Measurement; D019904:Polymethyl Methacrylate / Q000627:therapeutic use; D012189:Retrospective Studies; D012447:Sacrum / Q000601:surgery*; D016103:Spinal Fractures / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate
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