title: SOCE in neurons: Signaling or just refilling?
abstract: In this review we describe the present knowledge about store operated Ca²⁺ entry (SOCE) in neurons and the proteins involved in this process: STIM, as well as Orai and TRP channels. We address the issue of whether SOCE is used only to refill Ca²⁺ in the ER or whether Ca²⁺ that enters the neuronal cell during SOCE also performs signaling functions. We collected the data indicating that SOCE and its components participate in the important processes in neurons. This has implications for identifying new drug targets for the treatment of brain diseases. Evidence indicates that in neurodegenerative diseases Ca²⁺ homeostasis and SOCE components become dysregulated. Thus, different targets and strategies might be identified for the potential treatment of these diseases. This article is part of a Special Issue entitled: 13th European symposium on calcium.
authors: International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109 Warsaw, Poland.
authors: Lukasz
authors: L
authors: Majewski
authors: International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109 Warsaw, Poland. Electronic address: jacek.kuznicki@iimcb.gov.pl.
authors: Jacek
authors: J
authors: Kuznicki
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Neuron; Orai; STIM; Store operated calcium entry (SOCE); TRPC; Voltage-operated calcium channel