title: The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity.
abstract: The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.
authors: Division of Key Lab of Animal Disease Diagnosis and Immunology of China's Department of Agriculture, College of Veterinary Medicine, Nanjing Agriculture University, Nanjing 210095, China.
authors: Guang Fang
authors: GF
authors: Zhou
authors: Qing Tao
authors: QT
authors: Liu
authors: Bin
authors: B
authors: Zhou
authors: Ya Feng
authors: YF
authors: Qiu
authors: Xiao Dong
authors: XD
authors: Liu
authors: Zhi Yong
authors: ZY
authors: Ma
authors: Xiu Li
authors: XL
authors: Feng
authors: Rui Bing
authors: RB
authors: Cao
authors: Pu Yan
authors: PY
authors: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D030161:Avian Proteins / Q000494:pharmacology*; D002060:Bursa of Fabricius / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002645:Chickens / Q000276:immunology*; D006825:Hybridomas / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology*; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D015398:Signal Transduction / Q000187:drug effects*; D059467:Transcriptome
chemical_list: D000970:Antineoplastic Agents; D030161:Avian Proteins; D007155:Immunologic Factors
keywords: bursal septpeptide II; humoral immune system; pathway analysis; tumor suppressor p53
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