title: Therapeutic insights from genomic studies of head and neck squamous cell carcinomas.
abstract: Large and comprehensive genomic surveys of head and neck squamous cell carcinomas (HNSCC) are now greatly increasing our understanding of the diversity of this disease and the key genomic changes that drive these tumors. The results from these studies are beginning to inform the introduction of novel therapies for patients with HNSCCs. Here, we review some of the key findings from recent genomic studies of head and neck cancers, including the most comprehensive study to date from The Cancer Genome Atlas Network.
authors: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
authors: Peter S
authors: PS
authors: Hammerman
authors: Department of Hematology/Oncology, University of North Carolina Lineberger Cancer Center, Chapel Hill, North Carolina.
authors: D Neil
authors: DN
authors: Hayes
authors: Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. grandisjr@upmc.edu.
authors: Jennifer R
authors: JR
authors: Grandis
mesh_terms: D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D023281:Genomics / Q000379:methods; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D015415:Biomarkers
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