title: Meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of Sjögren syndrome.
abstract: OBJECTIVE
  To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS).
  
  
  METHODS
  Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis.
  
  
  RESULTS
  Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92).
  
  
  CONCLUSIONS
  The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Chuiwen
authors: C
authors: Deng
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Chaojun
authors: C
authors: Hu
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Si
authors: S
authors: Chen
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Jing
authors: J
authors: Li
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Xiaoting
authors: X
authors: Wen
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Ziyan
authors: Z
authors: Wu
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Yuan
authors: Y
authors: Li
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Fengchun
authors: F
authors: Zhang
authors: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors: Yongzhe
authors: Y
authors: Li
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D043587:Receptor, Muscarinic M3 / Q000276:immunology*; D012680:Sensitivity and Specificity; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D043587:Receptor, Muscarinic M3
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