title: Analgesic and anti-inflammatory activities of leaf extract of Mallotus repandus (Willd.) Muell. Arg.
abstract: In folk medicine Mallotus repandus (Willd.) Muell. Arg. is used to treat muscle pain, itching, fever, rheumatic arthritis, snake bite, hepatitis, and liver cirrhosis. This study aimed to evaluate the antinociceptive as well as the anti-inflammatory activities of the methanol extract of leaf. The leaves were extracted with methanol following hot extraction and tested for the presence of phytochemical constituents. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, xylene induced ear edema, cotton pellet induced granuloma, and tail immersion methods at doses of 500, 1000, and 2000 mg/kg body weight. The presence of flavonoids, saponins, and tannins was identified in the extract. The extract exhibited considerable antinociceptive and anti-inflammatory activities against four classical models of pain. In acetic acid induced writhing, xylene induced ear edema, and cotton pellet granuloma models, the extract revealed dose dependent activity. Additionally, it increased latency time in tail immersion model. It can be concluded that M. repandus possesses significant antinociceptive potential. These findings suggest that this plant can be used as a potential source of new antinociceptive and anti-inflammatory candidates. The activity of methanol extract is most likely mediated through central and peripheral inhibitory mechanisms. This study justified the traditional use of leaf part of this plant.
authors: Laboratory of Natural Products Research, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Md Mahadi
authors: MM
authors: Hasan
authors: Laboratory of Natural Products Research, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Nizam
authors: N
authors: Uddin
authors: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Md Rakib
authors: MR
authors: Hasan
authors: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: A F M Mahmudul
authors: AF
authors: Islam
authors: Laboratory of Natural Products Research, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Md Monir
authors: MM
authors: Hossain
authors: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Akib Bin
authors: AB
authors: Rahman
authors: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Md Sazzad
authors: MS
authors: Hossain
authors: Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Ishtiaque Ahmed
authors: IA
authors: Chowdhury
authors: Laboratory of Natural Products Research, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
authors: Md Sohel
authors: MS
authors: Rana
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D036461:Mallotus Plant / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
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