title: The off-target effects of nonspecific NK cells.
abstract: In this issue of Blood, Shah et al describe the onset of severe acute graft-versus-host disease (GVHD) in 5 of 9 patients who received infusions of ex vivo expanded donor natural killer (NK) cells after HLA-matched hematopoietic stem cell transplantation (HSCT).
authors: MD ANDERSON CANCER CENTER.
authors: Dean A
authors: http://orcid.org/0000-0001-6693-5392
authors: DA
authors: Lee
mesh_terms: D053330:4-1BB Ligand / Q000494:pharmacology*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000628:therapy*; D006086:Graft vs Host Disease / Q000473:pathology*; D006801:Humans; D019409:Interleukin-15 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000637:transplantation*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D053330:4-1BB Ligand; C569274:IL15 protein, human; D019409:Interleukin-15