title: The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma.
abstract: Here we tested the hypothesis that SNPs associated with prostate cancer risk, might differentially affect RNA expression in prostate cancer stroma. The most significant 35 SNP loci were selected from Genome Wide Association (GWA) studies of ~40,000 patients. We also selected 4030 transcripts previously associated with prostate cancer diagnosis and prognosis. eQTL analysis was carried out by a modified BAYES method to analyze the associations between the risk variants and expressed transcripts jointly in a single model. We observed 47 significant associations between eight risk variants and the expression patterns of 46 genes. This is the first study to identify associations between multiple SNPs and multiple in trans gene expression differences in cancer stroma. Potentially, a combination of SNPs and associated expression differences in prostate stroma may increase the power of risk assessment for individuals, and for cancer progression.
authors: Genomics Center, Loma Linda University, Loma Linda, California, 92354, United States of America.
authors: Xin
authors: X
authors: Chen
authors: Department of Pathology and Laboratory Medicine, University of California, Irvine, California, 92697, United States of America.|Department of Microbiology and Molecular Genetics, University of California, Irvine, California, 92697, United States of America.
authors: Michael
authors: M
authors: McClelland
authors: Department of Pathology and Laboratory Medicine, University of California, Irvine, California, 92697, United States of America.|Department of Statistics, The University of Akron, Akron, Ohio, 44325, United States of America.|Department of Family & Community Medicine, Northeast Ohio Medical University, Rootstown, Ohio, 44272, United States of America.
authors: Zhenyu
authors: Z
authors: Jia
authors: Department of Pathology and Laboratory Medicine, University of California, Irvine, California, 92697, United States of America.
authors: Farah B
authors: FB
authors: Rahmatpanah
authors: Department of Pathology and Laboratory Medicine, University of California, Irvine, California, 92697, United States of America.
authors: Anne
authors: A
authors: Sawyers
authors: Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, Arizona, 85004, United States of America.
authors: Jeffrey
authors: J
authors: Trent
authors: Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona, 85004, United States of America.
authors: David
authors: D
authors: Duggan
authors: Department of Pathology and Laboratory Medicine, University of California, Irvine, California, 92697, United States of America.
authors: Dan
authors: D
authors: Mercola
mesh_terms: D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis* / Q000235:genetics; D012307:Risk Factors
chemical_list: D012313:RNA
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