title: Long term therapeutic efficacy of a soft monobloc mandibular advancement device in adults with obstructive sleep apnea.
abstract: OBJECTIVE
  To evaluate the long term (48 months) therapeutic efficacy of a soft monobloc mandibular advancement device in adult patients with mild or moderate obstructive sleep apnea.
  
  
  METHODS
  The study population comprised 28 patients (6 female and 22 male, mean age 52.2 ± 6.8 years) affected by obstructive sleep apnea. After a baseline medical and somnographic examination, a functional examination of the stomatognathic system, and a questionnaire focused on sleep-related qualities and a daytime somnolence, each patient received an individual device. Two follow-ups were made 6 months (T1) and 48 months (T2) after soft monobloc mandibular advancement device treatment had been initiated, and all initial examinations were repeated.
  
  
  RESULTS
  The statistical analysis showed a significant decrease in body mass index value between T1 and T2 (ρ = 0,012), an increase of Epworth sleepiness scale value between T1 and T2 (ρ = 0,012), and a significant improvement and decrease of apnea/hypopnea index between T0 and T1 (ρ = 0,010) and between T0 and T2 (ρ = 0,013).
  
  
  CONCLUSIONS
  Treatment with the soft monobloc mandibular advancement device is a therapeutic solution with long term and stable effects (48 months) for patients suffering from mild or moderate obstructive sleep apnea.
authors: Department of Clinical Science and Translational Medicine, Orthodontics, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
authors: Fabiana
authors: F
authors: Ballanti
authors: Department of Clinical Science and Translational Medicine, Orthodontics, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
authors: Salvatore
authors: S
authors: Ranieri
authors: Department of Clinical Science and Translational Medicine, Orthodontics, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
authors: Alberto
authors: 0000-0002-7564-4885
authors: A
authors: Baldini
authors: Department of Clinical Science and Translational Medicine, Orthodontics, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
authors: Paola
authors: P
authors: Cozza
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D019186:Mandibular Advancement / Q000295:instrumentation* / Q000379:methods; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000628:therapy*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
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