title: Pharmaceutical process chemistry: evolution of a contemporary data-rich laboratory environment.
abstract: Over the past 20 years, the industrial laboratory environment has gone through a major transformation in the industrial process chemistry setting. In order to discover and develop robust and efficient syntheses and processes for a pharmaceutical portfolio with growing synthetic complexity and increased regulatory expectations, the round-bottom flask and other conventional equipment familiar to a traditional organic chemistry laboratory are being replaced. The new process chemistry laboratory fosters multidisciplinary collaborations by providing a suite of tools capable of delivering deeper process understanding through mechanistic insights and detailed kinetics translating to greater predictability at scale. This transformation is essential to the field of organic synthesis in order to promote excellence in quality, safety, speed, and cost efficiency in synthesis.
authors: Stéphane
authors: S
authors: Caron
authors: Nicholas M
authors: NM
authors: Thomson
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation*; D004345:Drug Industry / Q000295:instrumentation; D007753:Laboratories; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009930:Organic Chemicals