title: Growth factors and platelet-rich plasma: promising biological strategies for early intervertebral disc degeneration.
abstract: Intervertebral disc degeneration (IDD) is a complex process with the mechanism not fully elucidated. The current clinical treatments for IDD are mainly focused on providing symptomatic relief without addressing the underlying cause of the IDD. Biological therapeutic strategies to repair and regenerate the degenerated discs are drawing more attention. Growth factor therapy is one of the biological strategies and holds promising prospects. As a promising bioactive substance, platelet-rich plasma (PRP) is considered to be an ideal growth factor "cocktail" for intervertebral disc (IVD) restoration. Results from many in vitro and in vivo studies have confirmed the efficacy of growth factors and PRP in IVD repair and regeneration. It is essential to advance the research on growth factor therapy and associated mechanism for IDD. This article reviews the background of IDD, current concepts in growth factor and PRP-related therapy for IDD. Future research perspectives and clinical directions are also discussed.
authors: Department of Orthopaedics, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu, 210009, People's Republic of China.
authors: Shan-zheng
authors: SZ
authors: Wang
authors: Qing
authors: Q
authors: Chang
authors: Jun
authors: J
authors: Lu
authors: Chen
authors: C
authors: Wang
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000627:therapeutic use*; D007403:Intervertebral Disc / Q000473:pathology*; D055959:Intervertebral Disc Degeneration / Q000209:etiology / Q000628:therapy*; D053657:Platelet-Rich Plasma / Q000187:drug effects* / Q000378:metabolism; D012038:Regeneration; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
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