title: Near-normal values of extravascular lung water in children.
abstract: OBJECTIVE
  To define near-normal values of extravascular lung water indexed to body weight in children.
  
  
  METHODS
  Prospective multicenter observational study.
  
  
  METHODS
  Medical/surgical PICUs of 5 multinational hospitals.
  
  
  METHODS
  Fifty-eight children with a median age of 4 years (range 1 month to 17 year) with heterogeneous PICU admission diagnoses were included. Extravascular lung water measurements from these children were collected after resolution of their illness. Obtained values were indexed to actual body weight and height and subsequently related to age.
  
  
  METHODS
  None.
  
  
  RESULTS
  Extravascular lung water indexed to body weight correlated with age (r2 = 0.7) and could be categorized in three-age groups consisting of significantly different median extravascular lung water indexed to body weight values (5th-95th percentile): less than 1 year, 9-29 mL/kg; 1-5 years, 7-25 mL/kg; and 5-17 years, 5-13 mL/kg. Extravascular lung water indexed to height did not correlate to age and resulted in an age-independent near-normal value of less than 315 mL/m.
  
  
  CONCLUSIONS
  Younger children have higher values of extravascular lung water indexed to actual body weight. Age categorized near-normal values of extravascular lung water indexed to body weight are presented for possible clinical use. Furthermore, we suggest to index extravascular lung water to height, which seems to be age independent.
authors: 1Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. 2Emergency Department and Pediatric Intensive Care Unit, Pediatric Hospital "Bambino Gesù", IRCCS, Rome, Italy. 3Sektion Neonatologie/Pädiatrische Intensivmedizin, Universitätskinderklinik Hamburg-Eppendorfs, Hamburg, Germany. 4Pediatric Critical Care Medicine, University of California, Santa Barbara, CA.
authors: Anneliese
authors: A
authors: Nusmeier
authors: Corrado
authors: C
authors: Cecchetti
authors: Martin
authors: M
authors: Blohm
authors: Rick
authors: R
authors: Lehman
authors: Johannes
authors: J
authors: van der Hoeven
authors: Joris
authors: J
authors: Lemson
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015633:Extravascular Lung Water; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012016:Reference Values