title: Aberrant B-cell homeostasis in chronic GVHD.
abstract: Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.
authors: Division of Cell Therapy and Hematologic Malignancies, Department of Medicine, Duke Cancer Institute, Duke University, Durham, NC; and.
authors: Stefanie
authors: http://orcid.org/0000-0003-4551-6687
authors: S
authors: Sarantopoulos
authors: Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
authors: Jerome
authors: http://orcid.org/0000-0001-5526-4669
authors: J
authors: Ritz
mesh_terms: D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D015398:Signal Transduction / Q000276:immunology; D023001:Transplantation Tolerance
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