title: Relationships between renal parameters and serum and urine markers of inflammation in those with and without HIV infection.
abstract: We sought to determine the relationships among intrarenal and systemic inflammation and renal disease in HIV. We compared paired serum and urinary levels (normalized to urine creatinine) of monocyte chemotactic protein-1 (MCP-1), regulated on activation normal T cell expressed and secreted (RANTES), interferon-γ-induced protein-10 (IP-10), interleukin-8 (IL-8), and β2-microglobulin (B2M) between two groups of HIV-infected subjects not receiving antiretroviral therapy (ART) [A: not expecting to initiate ART immediately due to having CD4 cell counts ≥350/μl, N=26; B: about to initiate ART, N=19], a group of HIV-infected subjects receiving virologically suppressive antiretroviral therapy [C, N=30], and a group of HIV-uninfected, healthy volunteers [D, N=45]. We then correlated these inflammatory biomarker levels with urine protein/creatinine ratios (uPCR), urine albumin/creatinine ratios (uACR), and estimated glomerular filtration rates (eGFR). Urine inflammatory biomarker levels were highest in Group B. When combining all four study groups, statistically significant positive correlations included uPCR with urine IL-8, urine MCP-1, urine IP-10, and serum IP-10 and uACR with urine IL-8, urine B2M, serum IP-10, and serum B2M. eGFR was statistically significantly negatively correlated with serum MCP-1 and serum B2M. Paired serum and urine levels of IP-10 and B2M (but not IL-8, RANTES, or MCP-1) were significantly correlated with each other in the overall group. The levels of urine inflammatory markers tested differed by HIV status and use of virologically suppressive ART. These urine and serum inflammatory markers were differentially correlated with uPCR, uACR, and eGFR, suggesting that different intrarenal and systemic inflammatory pathways may contribute to different measures of nephropathy.
authors: 1 Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
authors: Takashi
authors: T
authors: Shinha
authors: Deming
authors: D
authors: Mi
authors: Ziyue
authors: Z
authors: Liu
authors: Christie M
authors: CM
authors: Orschell
authors: Michael M
authors: MM
authors: Lederman
authors: Samir K
authors: SK
authors: Gupta
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry*; D014556:Urine / Q000737:chemistry*
chemical_list: D015415:Biomarkers
references: Kidney Int. 2007 Dec;72(11):1380-7
references: 17805235
references: J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):279-83
references: 24278992
references: AIDS. 2009 Mar 27;23(6):689-96
references: 19262355
references: Antivir Ther. 2009;14(4):543-9
references: 19578239
references: J Infect Dis. 2009 Aug 15;200(4):614-8
references: 19591572
references: Clin J Am Soc Nephrol. 2010 Apr;5(4):607-15
references: 20203164
references: AIDS. 2010 Jul 17;24(11):1667-78
references: 20523203
references: J Acquir Immune Defic Syndr. 2010 Sep;55(1):73-7
references: 20098331
references: Am J Kidney Dis. 2010 Nov;56(5):872-82
references: 20709438
references: Antivir Ther. 2011;16(4):591-6
references: 21685547
references: J Am Soc Nephrol. 2011 Nov;22(11):2129-37
references: 21997394
references: J Infect Dis. 2011 Dec 15;204(12):1946-50
references: 22013226
references: J Am Soc Nephrol. 2012 Feb;23(2):343-50
references: 22135313
references: N Engl J Med. 2012 Jul 5;367(1):20-9
references: 22762315
references: BMC Nephrol. 2012;13:85
references: 22883485
references: PLoS One. 2013;8(4):e60852
references: 23593327
references: Nat Rev Nephrol. 2014 Oct;10(10):543
references: 25157835
references: Kidney Int. 2002 Jan;61(1):195-202
references: 11786101
references: Nephrol Dial Transplant. 2003 Feb;18(2):285-92
references: 12543882
references: J Acquir Immune Defic Syndr. 2003 Feb 1;32(2):203-9
references: 12571531
references: Clin Infect Dis. 2004 Oct 15;39(8):1199-206
references: 15486845
references: Am J Kidney Dis. 1996 Jun;27(6):803-8
references: 8651244
references: AIDS. 2007 May 11;21(8):1003-9
references: 17457094
references: Methods Mol Biol. 2013;1061:265-78
references: 23963943
references: Nephrol Dial Transplant. 2008 Oct;23(10):3130-7
references: 18469311