title: Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate: synthesis of enantioenriched trifluoromethylated compounds.
abstract: Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
authors: Li-Ying
authors: LY
authors: Zhang
authors: Jia-Hui
authors: JH
authors: Zhou
authors: Yun-He
authors: YH
authors: Xu
authors: Teck-Peng
authors: TP
authors: Loh
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003437:Crotonates / Q000737:chemistry*; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003437:Crotonates; D006845:Hydrocarbons, Fluorinated; D004364:Pharmaceutical Preparations; C000602341:methyl 4,4,4-trifluorocrotonate; D003300:Copper
keywords: 1,4-conjugate addition; 4,4,4-trifluorocrotonate; aliphatic Grignard reagents; copper catalysis