title: Viral IAPs, then and now.
abstract: The identification, now more than 20 years ago, of the first iap genes in baculoviruses subsequently led to many important discoveries concerning the regulation of apoptosis and other important biological processes in insects and mammals. Currently there are more than 200 known viral IAP homologs in baculoviruses and other families of invertebrate DNA viruses. This review begins with a personal account of the events leading up to the discovery of the first iap genes, followed by a summary of what is currently known about the different types of viral IAPs and their functions in regulating apoptosis, and possibly other cellular processes.
authors: Division of Biology, Kansas State University, Manhattan, KS, United States. Electronic address: rclem@ksu.edu.
authors: Rollie J
authors: RJ
authors: Clem
mesh_terms: D000818:Animals; D017209:Apoptosis; D049673:History, 20th Century; D051034:Inhibitor of Apoptosis Proteins / Q000737:chemistry / Q000235:genetics / Q000266:history* / Q000378:metabolism*; D010802:Phylogeny; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000266:history* / Q000378:metabolism*
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D014764:Viral Proteins; C086430:inhibitor of apoptosis, Nucleopolyhedrovirus
keywords: Apoptosis; Baculovirus; IAP; Insect virus