title: Systematic confirmation study of GWAS-identified genetic variants for Kawasaki disease in a Chinese population.
abstract: Genome-wide association studies (GWASs) have identified multiple single nucleotide polymorphisms (SNPs) associated with Kawasaki disease (KD). In this study, we replicated the associations of 10 GWAS-identified SNPs with KD in a Han Chinese population. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression, and cumulative effect of non-risk genotypes were also performed. Although none of the SNPs reached the corrected significance level, 4 SNPs showed nominal associations with KD risk. Compared with their respective wild type counterparts, rs1801274 AG+GG genotypes and rs3818298 TC+CC genotypes were nominally associated with the reduced risk of KD (OR = 0.77, 95% CI = 0.59-0.99, P = 0.045; OR = 0.74, 95% CI = 0.56-0.98, P = 0.038). Meanwhile, rs1801274 GG genotype, rs2736340 CC genotype or rs4813003 TT genotype showed a reduced risk trend (OR = 0.57, 95% CI = 0.35-0.93, P = 0.024; OR = 0.46, 95% CI = 0.26-0.83, P = 0.010; OR = 0.64, 95% CI = 0.43-0.94, P = 0.022), compared with rs1801274 AG+AA genotypes, rs2736340 CT+TT genotypes or rs4813003 TC+CC genotypes, respectively. Furthermore, a cumulative effect was observed with the ORs being gradually decreased with the increasing accumulative number of non-risk genotypes (Ptrend<0.001). In conclusion, our study suggests that 4 GWAS-identified SNPs, rs2736340, rs4813003, rs3818298 and rs1801274, were nominally associated with KD risk in a Han Chinese population individually and jointly.
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Jiao
authors: J
authors: Lou
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Rong
authors: R
authors: Zhong
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Na
authors: N
authors: Shen
authors: Guangdong Women and Children Hospital, Guangzhou, PR China.
authors: Xu-zai
authors: XZ
authors: Lu
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Jun-tao
authors: JT
authors: Ke
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Jia-yu
authors: JY
authors: Duan
authors: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
authors: Yan-qi
authors: YQ
authors: Qi
authors: Centre Hospitalier de l'Université de Montréal, CRCHUM-Hôpital Notre-Dame, Pavillion DeSève, Montreal, Canada.
authors: Yu-jia
authors: YJ
authors: Wang
authors: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
authors: Qing
authors: Q
authors: Zhang
authors: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
authors: Wei
authors: W
authors: Wang
authors: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
authors: Fang-qi
authors: FQ
authors: Gong
authors: Department of Epidemiology and Biostatistics and Key Laboratory of Environment and Health, Ministry of Education &Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Xiao-ping
authors: XP
authors: Miao
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D019013:CD40 Antigens / Q000235:genetics; D016022:Case-Control Studies; D056404:Chaperonin Containing TCP-1 / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics; D012306:Risk; D019061:src-Family Kinases / Q000235:genetics
chemical_list: D019013:CD40 Antigens; C445323:FCGR2A protein, human; D017452:Receptors, IgG; C533304:TCP1 protein, human; C584409:BLK protein, human; D019061:src-Family Kinases; D056404:Chaperonin Containing TCP-1
references: Bioinformatics. 2005 Jan 15;21(2):263-5
references: 15297300
references: PLoS One. 2014;9(8):e103329
references: 25093412
references: Pediatr Int. 2005 Apr;47(2):232-4
references: 15771703
references: Endocrinology. 2005 Jun;146(6):2684-91
references: 15731360
references: Thyroid. 2005 Oct;15(10):1119-24
references: 16279844
references: Thyroid. 2006 May;16(5):443-6
references: 16756465
references: J Neural Transm (Vienna). 2006 Oct;113(10):1537-43
references: 16465465
references: Nat Genet. 2008 Jan;40(1):35-42
references: 18084290
references: N Engl J Med. 2008 Feb 28;358(9):900-9
references: 18204098
references: Nat Genet. 2008 Oct;40(10):1216-23
references: 18794853
references: PLoS Genet. 2009 Jan;5(1):e1000319
references: 19132087
references: Genes Immun. 2009 Apr;10(3):219-26
references: 19225526
references: Nat Genet. 2009 Jul;41(7):820-3
references: 19503088
references: Arthritis Rheum. 2010 Mar;62(3):890-5
references: 20131239
references: Clin Exp Med. 2010 Dec;10(4):253-8
references: 20127135
references: Annu Rev Med. 2011;62:69-77
references: 20690826
references: PLoS One. 2011;6(2):e16853
references: 21326860
references: Pediatr Int. 2011 Feb;53(1):36-9
references: 20534021
references: Hum Genet. 2011 May;129(5):487-95
references: 21221998
references: Nat Genet. 2011 Dec;43(12):1241-6
references: 22081228
references: J Epidemiol. 2012;22(2):79-85
references: 22307434
references: Nat Genet. 2012 May;44(5):522-5
references: 22446961
references: Nat Genet. 2012 May;44(5):517-21
references: 22446962
references: J Epidemiol. 2012;22(3):216-21
references: 22447211
references: Mol Biol Rep. 2012 Dec;39(12):11137-44
references: 23065250
references: Hum Genet. 2013 Jun;132(6):669-80
references: 23456091
references: PLoS One. 2013;8(8):e72037
references: 24023612
references: Pediatr Neonatol. 2014 Apr;55(2):92-6
references: 24120536
references: J Exp Med. 2000 Jun 5;191(11):1813-7
references: 10839798
references: Electrophoresis. 2001 Apr;22(6):1233-41
references: 11358150
references: Life Sci. 2001 Jun 8;69(3):263-70
references: 11441917
references: J Neural Transm Suppl. 2001;(61):321-34
references: 11771755
references: Pediatrics. 2003 Feb;111(2):E140-7
references: 12563087
references: Thyroid. 2002 Dec;12(12):1129-35
references: 12593727
references: Thyroid. 2003 Oct;13(10):919-25
references: 14611700
references: J Med Genet. 2004 May;41(5):e63
references: 15121791
references: Lancet. 2004 Aug 7-13;364(9433):533-44
references: 15302199
references: Circulation. 2004 Oct 26;110(17):2747-71
references: 15505111
references: Pediatrics. 1974 Sep;54(3):271-6
references: 4153258
references: J Pediatr. 1975 Jun;86(6):892-8
references: 236368
references: Jpn Circ J. 1979 Jul;43(7):633-43
references: 41111
references: Am J Epidemiol. 1990 Mar;131(3):552-66
references: 2301364
references: J Biol Chem. 1992 Mar 5;267(7):4815-23
references: 1537861
references: Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9422-6
references: 8105476
references: Immunol Today. 1994 Sep;15(9):406-11
references: 7524518
references: Circulation. 1996 Sep 15;94(6):1379-85
references: 8822996
references: Am J Epidemiol. 1999 Apr 15;149(8):689-92
references: 10206617
references: Nat Rev Genet. 2005 Feb;6(2):95-108
references: 15716906