title: Vaccination approach to anti-angiogenic treatment of cancer.
abstract: Improvement of patient survival by anti-angiogenic therapy has proven limited. A vaccination approach inducing an immune response against the tumor vasculature combines the benefits of immunotherapy and anti-angiogenesis, and may overcome the limitations of current anti-angiogenic drugs. Strategies to use whole endothelial cell vaccines and DNA- or protein vaccines against key players in the VEGF signaling axis, as well as specific markers of tumor endothelial cells, have been tested in preclinical studies. Current clinical trials are now testing the promise of this specific anti-cancer vaccination approach. This review will highlight the state-of-the-art in this exciting field of cancer research.
authors: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands.
authors: Madelon Q
authors: MQ
authors: Wentink
authors: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands.
authors: Elisabeth J M
authors: EJ
authors: Huijbers
authors: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands.
authors: Tanja D
authors: TD
authors: de Gruijl
authors: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands.
authors: Henk M W
authors: HM
authors: Verheul
authors: Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden.
authors: Anna-Karin
authors: AK
authors: Olsson
authors: Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands. Electronic address: aw.griffioen@vumc.nl.
authors: Arjan W
authors: AW
authors: Griffioen
mesh_terms: D020533:Angiogenesis Inhibitors / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014611:Vaccination
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Angiogenesis; Immunology; Tumor vasculature; Vaccination