title: Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
abstract: Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of l-alanine residue at the N terminus and a non-proteinogenic amino acid, l-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme l-amino acid ligase (Lal) are also discussed.
authors: Department of Biological Sciences and Molecular Biology and Genetics, Middle East Technical University, 06800 Ankara, Turkey. Electronic address: ozcengiz@metu.edu.tr.
authors: Gülay
authors: G
authors: Özcengiz
authors: Marmara University, Research and Training Hospital, Division of Pediatric Allergy and Immunology, 34899 Istanbul, Turkey.
authors: İsmail
authors: İ
authors: Öğülür
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000502:physiology*; D004151:Dipeptides / Q000096:biosynthesis / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D008954:Models, Biological
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; C006674:bacilysin