title: Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.
abstract: Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. Because these alterations can contribute to age-related memory and mood impairments, strategies efficacious for mitigating these changes may preserve cognitive and mood function in old age. Resveratrol, a phytoalexin found in the skin of red grapes having angiogenic and antiinflammatory properties, appears ideal for easing these age-related changes. Hence, we examined the efficacy of resveratrol for counteracting age-related memory and mood impairments and the associated detrimental changes in the hippocampus. Two groups of male F344 rats in late middle-age having similar learning and memory abilities were chosen and treated with resveratrol or vehicle for four weeks. Analyses at ~25 months of age uncovered improved learning, memory and mood function in resveratrol-treated animals but impairments in vehicle-treated animals. Resveratrol-treated animals also displayed increased net neurogenesis and microvasculature, and diminished astrocyte hypertrophy and microglial activation in the hippocampus. These results provide novel evidence that resveratrol treatment in late middle age is efficacious for improving memory and mood function in old age. Modulation of the hippocampus plasticity and suppression of chronic low-level inflammation appear to underlie the functional benefits mediated by resveratrol.
authors: 1] Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott &amp;White, Temple, Texas, USA [2] Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA [3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA.
authors: Maheedhar
authors: M
authors: Kodali
authors: Department of Surgery (Neurosurgery) and Research Service, Duke University and Veterans' Affairs Medical Centers, Durham, North Carolina, USA.
authors: Vipan K
authors: VK
authors: Parihar
authors: 1] Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott &amp;White, Temple, Texas, USA [2] Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA [3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA [4] Department of Surgery (Neurosurgery) and Research Service, Duke University and Veterans' Affairs Medical Centers, Durham, North Carolina, USA.
authors: Bharathi
authors: B
authors: Hattiangady
authors: 1] Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott &amp;White, Temple, Texas, USA [2] Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA [3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA.
authors: Vikas
authors: V
authors: Mishra
authors: 1] Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott &amp;White, Temple, Texas, USA [2] Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA [3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA [4] Department of Surgery (Neurosurgery) and Research Service, Duke University and Veterans' Affairs Medical Centers, Durham, North Carolina, USA.
authors: Bing
authors: B
authors: Shuai
authors: 1] Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine at Scott &amp;White, Temple, Texas, USA [2] Research Service, Olin E. Teague Veterans Affairs Medical Center, Central Texas Veterans Health Care System, Temple, Texas, USA [3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, Texas, USA [4] Department of Surgery (Neurosurgery) and Research Service, Duke University and Veterans' Affairs Medical Centers, Durham, North Carolina, USA.
authors: Ashok K
authors: AK
authors: Shetty
mesh_terms: D000375:Aging; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D002478:Cells, Cultured; D000089622:Doublecortin Domain Proteins; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000473:pathology / Q000517:prevention & control; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055806:Microvessels / Q000187:drug effects* / Q000378:metabolism; D019964:Mood Disorders / Q000473:pathology / Q000517:prevention & control; D055495:Neurogenesis / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D039481:CD11b Antigen; D000089622:Doublecortin Domain Proteins; D005904:Glial Fibrillary Acidic Protein; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D013267:Stilbenes; D000077185:Resveratrol
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