title: Is time of the essence? Delayed diagnosis of Ewing's sarcoma.
abstract: Rarely in modern medicine are we able to observe the natural history of a patient with a sarcoma. This unusual case provides that opportunity. A CT scan was performed on the leg of a 15-year-old boy with a tender soft tissue mass on the lateral aspect of his left calf. Despite showing a lesion consistent with a sarcoma, neither the patient nor his family was informed. Almost a year and a half later, the patient returned and was diagnosed with Ewing's sarcoma. A staging work up showed no metastatic disease. After undergoing chemotherapy and a complete surgical resection of the tumour, the patient remains disease-free 10 years later, indicating that the biology of Ewing's sarcoma may be more important than time to diagnosis in determining outcome.
authors: Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
authors: Madeline
authors: M
authors: Edwards
authors: Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
authors: Jacqueline
authors: J
authors: Halton
authors: Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
authors: Raveena
authors: R
authors: Ramphal
authors: Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
authors: Donna
authors: D
authors: Johnston
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D003131:Combined Modality Therapy; D057210:Delayed Diagnosis; D006801:Humans; D008297:Male; D011859:Radiography; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging* / Q000628:therapy*
references: Virchows Arch. 2010 Feb;456(2):219-34
references: 19936782
references: J Bone Joint Surg Br. 2007 Sep;89(9):1229-33
references: 17905963
references: Br J Cancer. 2001 Nov 30;85(11):1646-54
references: 11742482
references: Pediatr Hematol Oncol. 2004 Jan-Feb;21(1):37-48
references: 14660305
references: J Pediatr. 1991 Nov;119(5):725-32
references: 1941378
references: J Clin Oncol. 2010 Jul 10;28(20):3284-91
references: 20547982
references: Eur J Cancer. 2004 Oct;40(15):2280-6
references: 15454254
references: J Clin Oncol. 2014 Jun 20;32(18):1935-40
references: 24841977
references: Cancer. 2007 Aug 15;110(4):703-13
references: 17620277
references: Cancer Treat Rev. 2010 Jun;36(4):277-85
references: 20231056
references: Arch Dis Child. 2014 Mar;99(3):244-50
references: 24265414