title: Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis.
abstract: Several amino acid ligands were introduced into the Hoveyda-Grubbs 2nd generation complex by a facile anionic ligand exchange. The chiral pre-catalysts obtained displayed enantioselectivity in asymmetric ring-closing and ring-opening cross-metathesis reactions. Reduction of the lability of the carboxylate ligands was found to be cardinal for improving the observed enantiomeric product enrichment.
authors: Chemistry Department, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. lemcoff@bgu.ac.il.
authors: Elisa
authors: E
authors: Ivry
authors: Amos
authors: A
authors: Ben-Asuly
authors: Israel
authors: I
authors: Goldberg
authors: N Gabriel
authors: NG
authors: Lemcoff
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D007474:Ion Exchange; D008024:Ligands; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000596:Amino Acids; D056831:Coordination Complexes; D008024:Ligands; D012428:Ruthenium