title: Marine and soil derived natural products: a new source of novel cardiovascular protective agents targeting the endothelin system.
abstract: Inhibition of the endothelin system is a recognized therapeutic approach for treating complex cardiovascular diseases. The search for natural inhibitors of the endothelin system has focused mainly on land, with recent, emerging data suggesting the underestimated potential of marine microorganisms for producing leads with cardioprotective potential. The present work reviews natural products identified as inhibitors of the endothelin system, their origin, their mechanism of action, and their ecological significance.
authors: Institute for Scientific Research and High Technology Services, City of Knowledge, Clayton, Panama, Republic of Panama.
authors: Nadir
authors: N
authors: Planes
authors: Institute for Scientific Research and High Technology Services, City of Knowledge, Clayton, Panama, Republic of Panama.
authors: Catherina
authors: C
authors: Caballero-George
mesh_terms: D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000302:isolation & purification / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D016232:Endothelins / Q000037:antagonists & inhibitors*; D006801:Humans; D020011:Protective Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D012988:Soil Microbiology
chemical_list: D001688:Biological Products; D016232:Endothelins; D020011:Protective Agents