title: Regulation of IGF -1 signaling by microRNAs.
abstract: The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological processes including development, homeostasis, and aging. Dysregulation of this pathway has been implicated in a myriad of diseases such as cancers, neurodegenerative diseases, and metabolic disorders, making the IGF-1 signaling pathway a prime target to develop therapeutic and intervention strategies. Recently, small non-coding RNA molecules in ∼22 nucleotide length, microRNAs (miRNAs), have emerged as a new regulator of biological processes in virtually all organ systems and increasing studies are linking altered miRNA function to disease mechanisms. A miRNA binds to 3'UTRs of multiple target genes and coordinately downregulates their expression, thereby exerting a profound influence on gene regulatory networks. Here we review the components of the IGF-1 signaling pathway that are known targets of miRNA regulation, and highlight recent studies that suggest therapeutic potential of these miRNAs against various diseases.
authors: Department of Genetics, Albert Einstein College of Medicine New York, NY, USA.
authors: Hwa Jin
authors: HJ
authors: Jung
authors: Department of Genetics, Albert Einstein College of Medicine New York, NY, USA ; Department of Medicine, Albert Einstein College of Medicine New York, NY, USA ; Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine New York, NY, USA.
authors: Yousin
authors: Y
authors: Suh
keywords: IGF-1 signaling; aging; aging-related disease; microRNAs; therapeutic agents
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