title: Synthesis of triphenylphosphonium phospholipid conjugates for the preparation of mitochondriotropic liposomes.
abstract: Surface modification of liposomes with a ligand is facilitated by the conjugation of the ligand to a hydrophobic molecule that serves to anchor the ligand to the liposomal bilayer. We describe here a simple protocol to conjugate a triphenylphosphonium group to several commercially available functionalized phospholipids. The resulting triphenylphosphonium conjugated lipids can be used to prepare liposomes that preferentially associate with mitochondria when exposed to live mammalian cells in culture.
authors: Parul
authors: P
authors: Benien
authors: Department of Pharmaceutical Sciences, School of Pharmacy-Boston, MCPHS University, 179 Longwood Avenue, Boston, MA, 02115, USA.
authors: Parul
authors: P
authors: Benein
authors: Mohammed A
authors: MA
authors: Almuteri
authors: Ahmed S
authors: AS
authors: Mehanna
authors: Gerard G M
authors: GG
authors: D'Souza
mesh_terms: D008081:Liposomes / Q000737:chemistry*; D008928:Mitochondria / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D012997:Solvents
chemical_list: D008081:Liposomes; D009943:Organophosphorus Compounds; D010743:Phospholipids; D012997:Solvents