title: We know very little about the subjective effects of drugs in females.
abstract: Pharmaceutical companies assessing the nervous system effects of candidate therapeutics often use a behavioral assay in rodents that assesses the drug's subjective (internal stimulus) effects. Variants of this so-called "drug discrimination task" have also been widely used by basic scientist for more than 50 years to study the receptor actions of a host of ligands related to disease states and neuropathologies. Notably, most published research with this task has used male rats or mice. This situation is unfortunate and severely limits the utility of the research, given the well-documented differences between women and men on drug efficacy and safety, as well as known sex differences in the neural and behavioral effects of drugs. In this Viewpoint, we highlight the need for basic researchers, as well as pharmaceutical scientists, to include females in drug discrimination studies in a manner that allows detection and interpretation of potential sex differences.
authors: Behavioral Neuropharmacology Lab, Department of Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0308, United States.
authors: Rick A
authors: RA
authors: Bevins
authors: Behavioral Neuropharmacology Lab, Department of Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0308, United States.
authors: Sergios
authors: S
authors: Charntikov
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D012727:Sex Characteristics
chemical_list: D002491:Central Nervous System Agents
keywords: Drug discrimination; gender differences; interoceptive stimuli; sex differences
references: Genome Res. 2006 Aug;16(8):995-1004
references: 16825664
references: Neurosci Biobehav Rev. 2011 Jan;35(3):565-72
references: 20620164
references: Biol Sex Differ. 2013 Jul 31;4(1):14
references: 23902594
references: Nature. 2014 May 15;509(7500):282-3
references: 24834516