title: Hemodynamic monitoring of large animal chronic studies after median sternotomy: experiences with different telemetric physiological devices.
abstract: Telemetric physiological monitoring systems (TPMS) have enabled accurate continuous measurement of animal blood pressures and flows. However, few studies describe approaches for use of TPMS in the great vessels or inside the heart. We describe our initial experiences using two types of TPMSs. Twelve lambs (20-37 kg) underwent sternotomy. Two lambs were not instrumented and were killed at 14 days to confirm normal sternal wound healing (sham group, n = 2). Ten lambs underwent placement of either standard indwelling pressure-monitoring catheter and perivascular-flow-probe (CFP group, n = 3) or TPMS implantation (TPMS group, n = 7). The TPMS used were EG1-V3S2T-M2 (EG1, n = 5; Transonic Endogear Inc.) and Physio Tel Digital L21 (PTD, n = 2; Data Sciences Inc.). Two deaths because of respiratory problems occurred in TPMS group, attributed to lung compression by the implanted device. In TPMS group, more consistent trends of blood pressures and flows were recorded, and management of animals was easier and less labor-intensive. Comparing the two TPMSs, the initiation and renewal costs for each case was $28 K vs. $20 K and $1,700 vs. $0, (PTD versus EG1, respectively). In conclusion, TPMS implantation was feasible via median sternotomy in lambs. Telemetric physiological monitoring systems significantly improve reliability of hemodynamic monitoring in chronic survival animal study. EG1 was less costly than PTD.
authors: From the *Division of Pediatric Cardiac Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California; †Transonic EndoGear Inc, Davis, California; and ‡Department of Medicine and Epidemiology, University of California, Davis, School of Veterinary Medicine, Davis, California.
authors: Yasuhiro
authors: Y
authors: Fujii
authors: Koullis
authors: K
authors: Pitsillides
authors: Giuseppe
authors: G
authors: Ferro
authors: Hiroshi
authors: H
authors: Kagawa
authors: Luca
authors: L
authors: Centola
authors: Katsushi
authors: K
authors: Kinouchi
authors: Liqun
authors: L
authors: Zhu
authors: William T
authors: WT
authors: Ferrier
authors: Linda
authors: L
authors: Talken
authors: Teimour
authors: T
authors: Nasirov
authors: R Kirk
authors: RK
authors: Riemer
authors: Olaf
authors: O
authors: Reinhartz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology*; D008991:Monitoring, Physiologic / Q000379:methods*; D012756:Sheep; D056346:Sternotomy; D013686:Telemetry / Q000379:methods*