title: Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release.
abstract: Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO2) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO2 nanoparticles can act as a transparent inorganic sunscreen.
authors: Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil.
authors: Eloísa Berbel
authors: EB
authors: Manaia
authors: Physical-Chemistry Department, Chemistry Institute, São Paulo State University - UNESP, Araraquara, Brazil.
authors: Renata Cristina Kiatkoski
authors: RC
authors: Kaminski
authors: Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil.
authors: Anselmo Gomes
authors: AG
authors: de Oliveira
authors: Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil.
authors: Marcos Antonio
authors: MA
authors: Corrêa
authors: Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil.
authors: Leila Aparecida
authors: LA
authors: Chiavacci
mesh_terms: D003692:Delayed-Action Preparations; D050866:Liquid Crystals / Q000737:chemistry*; D008857:Microscopy, Interference; D053758:Nanoparticles / Q000737:chemistry; D013473:Sunscreening Agents / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D013473:Sunscreening Agents; D013729:Terpenes; C009495:titanium dioxide; C034019:terpinenol-4; D014025:Titanium
keywords: drug delivery; sol-gel; sunscreen; titanium dioxide
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