title: Impact of hyperuricaemia on the chronic kidney disease-associated risk factors in a community-based population.
abstract: OBJECTIVE
  Hyperuricaemia is a common finding in subjects with lifestyle related diseases. This study was performed to examine its association with chronic kidney disease (CKD) in relation to other risk factors in a community-based population.
  
  
  METHODS
  Data from 187 914 participants, excepting CKD stage 5, of the health check-up were included in this analysis. The association between CKD and its risk factors were examined by a logistic analysis. The association of hyperuricaemia and CKD was also compared in the population without any lifestyle related diseases and the whole population.
  
  
  RESULTS
  The prevalence of hyperuricaemia was significantly higher in the advanced stage of CKD. The odds ratio of hyperuricaemia was higher than that of other factors for the association with CKD. The odds ratio of many CKD-associated variables was increased in the advanced stage. Among them, the odds ratio of hyperuricaemia was markedly increased. The prevalence of hyperuricaemia was lower in the population without any lifestyle related diseases than in the whole population in the early stages, the difference of prevalence between the two populations becoming smaller in the advanced stage.
  
  
  CONCLUSIONS
  The association of incident CKD with hyperuricaemia was stronger than with other chronic kidney disease-risk factors, this association becoming more significant in the advanced stage of chronic kidney disease. Although this result does not indicate the cause and result relationship, the data suggest that hyperuricaemia might not be appropriately treated in this population.
authors: School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
authors: Yoshiko
authors: Y
authors: Tsumuraya
authors: Tomo
authors: T
authors: Hirayama
authors: Emiko
authors: E
authors: Tozuka
authors: Wakana
authors: W
authors: Furuta
authors: Shinobu
authors: S
authors: Utsugi
authors: Atsuko
authors: A
authors: Tsuchiya
authors: Akira
authors: A
authors: Hishida
authors: Hiromichi
authors: H
authors: Kumagai
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006306:Health Surveys; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: chronic kidney disease; health check-up; hyperuricaemia; risk factor; uric acid