title: Comparison of pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus between wild and domestic pigs.
abstract: The objective of this study was to compare the pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection between wild and domestic pigs based on clinical, immunological, and pathological evaluation. Upon challenge with HP-PRRSV, five wild pigs died compared to none of the domestic. Anti-PRRSV antibody titers were significantly (P < 0.05) higher in wild HP-PRRSV-infected pigs versus the domestic HP-PRRSV-infected pigs at 21 days post inoculation (dpi). Lung lesion scores at 7 dpi were also significantly (P < 0.01) higher in domestic infected pigs than wild infected pigs. The most striking difference was the viral tissue distribution between the wild and domestic HP-PRRSV-infected pigs. HP-PRRSV-positive cells were observed in bronchiolar, gastric, and renal tubular epithelial cells from wild HP-PRRSV-infected pigs only. The results in this study demonstrated a genetic difference exists between wild and domestic pigs, which could results in different clinical signs, immunological responses, and pathological outcomes to HP-PRRSV infection.
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
authors: T D
authors: TD
authors: Do
authors: C
authors: C
authors: Park
authors: K
authors: K
authors: Choi
authors: J
authors: J
authors: Jeong
authors: M K
authors: MK
authors: Vo
authors: T T
authors: TT
authors: Nguyen
authors: C
authors: C
authors: Chae
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000821:virology*; D000835:Animals, Wild / Q000821:virology*; D008168:Lung / Q000473:pathology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000235:genetics / Q000276:immunology / Q000401:mortality / Q000473:pathology* / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000472:pathogenicity*; D013552:Swine
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