title: Intratumoral lymphatic vessel density as a predictor of progression-free and overall survival in locally advanced laryngeal/hypopharyngeal cancer.
abstract: Lymphatic vessel density (LVD) has been shown to be an important predictor of survival in head and neck cancers. We report the predictive value of LVD for progression-free survival (PFS) and overall survival (OS) in laryngeal/hypopharyngeal cancer.
  
  
  
  Fifty-five untreated patients with T3/T4 laryngeal and T4 hypopharyngeal cancer underwent laryngectomy between 1999 and 2010. Surgical specimens were immunostained with D2-40, a specific lymphatic marker. LVDs were determined in tumor vessel "hot spots." Recursive partitioning analysis identified LVD thresholds for both peritumoral (LVDpt) and intratumoral (LVDit) vessels for association with PFS and OS.
  
  
  
  Patients with mean LVDit of <11 vessels/mm(2) had 2-year PFS and OS rates of 58% and 65%, respectively, compared to 13% and 13% for those with LVDit ≥11 vessels/mm(2) (p = .06 and .04, respectively).
  
  
  
  Intratumoral lymphatic vessel density is predictive of PFS and OS in locally advanced laryngeal/hypopharyngeal cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E417-E420, 2016.
authors: Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Newton J
authors: 0000-0002-8812-8003
authors: NJ
authors: Hurst
authors: Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Michael
authors: M
authors: Dominello
authors: Department of Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Gregory
authors: G
authors: Dyson
authors: Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Hayan
authors: H
authors: Jaratli
authors: Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Meenu
authors: M
authors: Sharma
authors: Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Yasin K
authors: YK
authors: Ahmed
authors: Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Antoine E
authors: AE
authors: Melkane
authors: Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Christopher
authors: C
authors: Rose
authors: Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: John
authors: J
authors: Jacobs
authors: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.
authors: Tamar
authors: T
authors: Giorgadze
authors: Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
authors: Harold
authors: H
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis*; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels; D008297:Male; D008875:Middle Aged; D011379:Prognosis
keywords: D2-40; immunohistochemistry; laryngeal/hypopharyngeal cancer; lymphatic vessel density; prognosis