title: Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival.
abstract: OBJECTIVE
  To investigate the clinicopathological signiﬁcance and prognostic value of caveolin-1 (CAV-1) in both tumor and stromal cells in colorectal cancer (CRC).
  
  
  METHODS
  A total of 178 patients with CRC were included in this study. The correlation between CAV-1 expression and clinicopathologic features and survival was studied.
  
  
  RESULTS
  CAV-1 expression was detected in tumor and stromal cells. The expression of stromal CAV-1 was closely associated with histological type (P=0.022), pathologic tumor-node-metastasis stage (P=0.047), pathologic N stage (P=0.035) and recurrence (P=0.000). However, tumor cell CAV-1 did not show any correlation with clinical parameters. Additionally, the loss of stromal CAV-1 expression was associated with shorter disease-free survival (P=0.000) and overall survival (P=0.000). Multivariate analysis revealed that the loss of stromal CAV-1 expression was an independent prognostic factor for both overall survival (P=0.014) and disease-free survival (P=0.006).
  
  
  CONCLUSIONS
  The loss of stromal CAV-1 expression in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Zhi
authors: Z
authors: Zhao
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Fang-Hai
authors: FH
authors: Han
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Shi-Bin
authors: SB
authors: Yang
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Li-Xin
authors: LX
authors: Hua
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Jian-Hai
authors: JH
authors: Wu
authors: Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
authors: Wen-Hua
authors: WH
authors: Zhan
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D051242:Caveolin 1 / Q000032:analysis*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D017154:Stromal Cells / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1
keywords: CAV-1; Colorectal cancer; Prognosis; Stroma
references: Biochemistry. 2000 Nov 14;39(45):13916-24
references: 11076533
references: J Cell Sci. 2006 Mar 1;119(Pt 5):787-96
references: 16495479
references: J Cell Physiol. 2013 Aug;228(8):1651-7
references: 23460038
references: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1381-5
references: 7877987
references: Am J Pathol. 2009 Mar;174(3):746-61
references: 19234134
references: Ann Surg Oncol. 2014 Jan;21(1):329-36
references: 23982252
references: Antioxid Redox Signal. 2012 Jun 1;16(11):1264-84
references: 21883043
references: Cell Cycle. 2009 Aug;8(15):2420-4
references: 19556867
references: Carcinogenesis. 2013 Sep;34(9):2109-18
references: 23640045
references: Cell Cycle. 2010 May 15;9(10):1960-71
references: 20495363
references: Lab Invest. 2009 Jun;89(6):614-23
references: 19333235
references: J Biol Chem. 2004 Dec 3;279(49):51630-46
references: 15355971
references: Semin Cell Dev Biol. 2010 Feb;21(1):19-25
references: 19857592
references: Cancers (Basel). 2013 Jan 31;5(1):149-69
references: 24216702
references: J Biol Chem. 1997 Mar 7;272(10):6525-33
references: 9045678
references: CA Cancer J Clin. 2013 Jan;63(1):11-30
references: 23335087
references: Annu Rev Pathol. 2012;7:423-67
references: 22077552
references: Am J Pathol. 2009 Jun;174(6):2023-34
references: 19411448
references: BMC Urol. 2011;11:25
references: 22152020
references: Biochemistry. 2001 Mar 20;40(11):3354-62
references: 11258956
references: Pathol Oncol Res. 2012 Apr;18(2):459-69
references: 22057638
references: Cancer Sci. 2011 Aug;102(8):1590-6
references: 21585620
references: Oncogene. 2000 Jul 6;19(29):3256-65
references: 10918582
references: Mol Biol Rep. 2013 Dec;40(12):6561-8
references: 24197691
references: Cell Cycle. 2010 Jun 15;9(12):2423-33
references: 20562526
references: PLoS One. 2013;8(3):e59102
references: 23527097
references: Science. 2001 Sep 28;293(5539):2404-5
references: 11577223
references: Gastrointest Endosc. 2012 May;75(5):1072-9
references: 22520880
references: Semin Cancer Biol. 2014 Apr;25:47-60
references: 24486645
references: Cell Cycle. 2009 Dec;8(23):3984-4001
references: 19923890
references: Cancer Biol Ther. 2010 Jul 15;10(2):135-43
references: 20431349
references: J Pathol. 2013 Sep;231(1):77-87
references: 23729330