title: Tracking discourse complexity preceding Alzheimer's disease diagnosis: a case study comparing the press conferences of Presidents Ronald Reagan and George Herbert Walker Bush.
abstract: Changes in some lexical features of language have been associated with the onset and progression of Alzheimer's disease. Here we describe a method to extract key features from discourse transcripts, which we evaluated on non-scripted news conferences from President Ronald Reagan, who was diagnosed with Alzheimer's disease in 1994, and President George Herbert Walker Bush, who has no known diagnosis of Alzheimer's disease. Key word counts previously associated with cognitive decline in Alzheimer's disease were extracted and regression analyses were conducted. President Reagan showed a significant reduction in the number of unique words over time and a significant increase in conversational fillers and non-specific nouns over time. There was no significant trend in these features for President Bush.
authors: Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
authors: Visar
authors: V
authors: Berisha
authors: Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
authors: Shuai
authors: S
authors: Wang
authors: Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
authors: Amy
authors: A
authors: LaCross
authors: Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
authors: Julie
authors: J
authors: Liss
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000266:history; D003072:Cognition Disorders / Q000209:etiology*; D018450:Disease Progression; D049673:History, 20th Century; D006801:Humans; D007857:Leadership; D008297:Male; D009483:Neuropsychological Tests
keywords: Early diagnosis; language; medical informatics; natural language processing
references: Psychol Aging. 2001 Dec;16(4):600-14
references: 11766915
references: Brain. 2005 May;128(Pt 5):1093-101
references: 15774508
references: JAMA. 1996 Feb 21;275(7):528-32
references: 8606473
references: J Exp Psychol. 1968 Jan;76(1):Suppl:1-25
references: 5672258
references: J Speech Hear Res. 1985 Sep;28(3):405-10
references: 4046581
references: Brain Lang. 2000 Jun 1;73(1):17-49
references: 10872636
references: Neurobiol Aging. 2005 Mar;26(3):341-7
references: 15639312
references: J Am Geriatr Soc. 1997 May;45(5):584-9
references: 9158579
references: Brain Lang. 1989 May;36(4):533-42
references: 2720369
references: Psychol Aging. 2003 Jun;18(2):332-9
references: 12825780