title: Reactivation of hepatitis B virus without core antibody.
abstract: We present the case of a male patient not vaccinated against hepatitis B virus (HBV) and with reactivity to a surface antibody who, after immunosuppression for a multiple myeloma, had HBV reactivation. Pharmacological HBV suppression was tried, but viremia could not be suppressed. Production-detection core mutations or immunity issues can explain this clinical phenomenon.
authors: Infectious Diseases Department, Hospital São João, Porto, Portugal Faculty of Medicine of University of Porto, Porto, Portugal pintoandre@gmail.com.
authors: André
authors: A
authors: Silva-Pinto
authors: Haematology Department, Hospital São João, Porto, Portugal.
authors: Joaquim
authors: J
authors: Andrade
authors: Faculty of Medicine of University of Porto, Porto, Portugal Blood Bank and Transfusion Medicine Department, Hospital São João, Porto, Portugal.
authors: Fernando
authors: F
authors: Araújo
authors: Infectious Diseases Department, Hospital São João, Porto, Portugal Faculty of Medicine of University of Porto, Porto, Portugal.
authors: Lurdes
authors: L
authors: Santos
authors: Infectious Diseases Department, Hospital São João, Porto, Portugal Faculty of Medicine of University of Porto, Porto, Portugal.
authors: António
authors: A
authors: Sarmento
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006509:Hepatitis B / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy
chemical_list: D000998:Antiviral Agents; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; C413685:entecavir; D006147:Guanine
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