title: Establishment of a cervical cancer bio-bank for the Chinese population: from project-based sample collection to routine management.
abstract: OBJECTIVE
  There is an increasing need for the establishment of a cervical cancer bio-bank that will facilitate both clinical and basic research.
  
  
  METHODS
  The cervical cancer bio-bank was first established in January 1999 and included two stages. First, a GWAS-based sample collection was conducted with special emphasis on the diagnosis and the retrieval of the corresponding bio-specimens, especially blood samples. Second, clinical data and their corresponding bio-specimens were routinely collected and handled. Notably, these bio-specimens also included samples from Wufeng Tujia Autonomous County, which has the highest incidence of cervical cancer in China. The specimens were collected from patients with cervical cancer and those with cervical intraepithelial neoplasia, while the control samples were collected from normal individuals.
  
  
  RESULTS
  With special emphasis on clinical data and blood samples for the GWAS analysis, the collection of other bio-specimens was slow, and the pairing of specimens and clinical data was poor during the first stage. However, in the second stage, the pairing of the clinical data and its corresponding bio-specimens improved. At present, the samples procured and preserved in the bio-bank cover most regions of China and different ethnic groups for both the normal controls and cervical cancer patients of different pathological categories.
  
  
  CONCLUSIONS
  This bio-bank of cervical cancer specimens from the Chinese population will greatly promote the studies of cervical cancer in China.
authors: Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Ru
authors: R
authors: Yang
authors: Xiong
authors: X
authors: Li
authors: Hang
authors: H
authors: Zhou
authors: Yao
authors: Y
authors: Jia
authors: Jin
authors: J
authors: Zhou
authors: Kecheng
authors: K
authors: Huang
authors: Fangxu
authors: F
authors: Tang
authors: Ting
authors: T
authors: Hu
authors: Jian
authors: J
authors: Shen
authors: Zhilan
authors: Z
authors: Chen
authors: Shaoshuai
authors: S
authors: Wang
authors: Haiying
authors: H
authors: Sun
authors: Lili
authors: L
authors: Guo
authors: Lin
authors: L
authors: Wang
authors: Hui
authors: H
authors: Wang
authors: Ding
authors: D
authors: Ma
authors: Shuang
authors: S
authors: Li
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D014015:Tissue Banks; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000208:ethnology* / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000097:blood / Q000208:ethnology* / Q000473:pathology*