title: Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis.
abstract: Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6″-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data. Among these compounds, lonicerosides A and L had potent melanogenesis stimulatory activity in murine B16F0 melanoma cells. The structural relationship of active compounds was discussed.
authors: Biomolecular Science, University of Science and Technology, UST, Daejeon, 305-806, Korea.
authors: Yu-Mi
authors: YM
authors: Won
authors: Zuh-Kyung
authors: ZK
authors: Seong
authors: Jae-Lim
authors: JL
authors: Kim
authors: Hui-Seong
authors: HS
authors: Kim
authors: Hyuk-Hwan
authors: HH
authors: Song
authors: Doo-Young
authors: DY
authors: Kim
authors: Jung-Hee
authors: JH
authors: Kim
authors: Sei-Ryang
authors: SR
authors: Oh
authors: Hyun-Woo
authors: HW
authors: Cho
authors: Jung-Hee
authors: JH
authors: Cho
authors: Hyeong-Kyu
authors: HK
authors: Lee
mesh_terms: D000818:Animals; D027922:Caprifoliaceae; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D008543:Melanins / Q000378:metabolism*; D008546:Melanoma, Experimental; D051379:Mice; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D008543:Melanins; D010936:Plant Extracts; D014315:Triterpenes