title: Intratumor molecular and phenotypic diversity in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma is a highly heterogeneous disease both at the molecular and clinical levels. Intratumor morphologic and genetic heterogeneity adds a new level of complexity in our understanding of liver carcinogenesis, and it is likely an important determinant of primary and secondary resistance to targeted therapies. Clin Cancer Res; 21(8); 1786-8. ©2015 AACR. See related article by Friemel et al., p. 1951.
authors: Inserm, UMR-1162, Génomique fonctionnelle des Tumeurs solides, IUH, Paris, France. Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Service d'Hépatologie, Hôpital Jean Verdier, AP-HP, Bondy, and Université Paris 13, Bobigny, France.
authors: Jean-Charles
authors: JC
authors: Nault
authors: Liver Cancer Research Program, Division of Liver Diseases, Division of Hematology and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York. augusto.villanueva@mssm.edu.
authors: Augusto
authors: A
authors: Villanueva
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male