title: Salivary proteomics and biomarkers in neurology and psychiatry.
abstract: Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective and earlier diagnoses of CNS conditions. Proteomics and other omics MS-based technologies are tools currently being utilized in much recent CNS research. Saliva is an interesting alternative biomaterial for the proteomic study of CNS disorders, with several advantages. Collection is noninvasive and saliva has many proteins. It is easier to collect than blood and can be collected by professionals without formal medical training. For psychiatric and neurological patients, supplying a saliva sample is less anxiety-provoking than providing a blood sample, and is less embarrassing than producing a urine specimen. The use of saliva as a biomaterial has been researched for the diagnosis of and greater understanding of several CNS conditions, including neurodegenerative diseases, autism, and depression. Salivary biomarkers could be used to rule out nonpsychiatric conditions that are often mistaken for psychiatric/neurological conditions, such as fibromyalgia, and potentially to assess cognitive ability in individuals with compromised brain function. As MS and omics technology advances, the sensitivity and utility of assessing CNS conditions using distal human biomaterials such as saliva is becoming increasingly possible.
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Kelly L
authors: KL
authors: Wormwood
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Roshanak
authors: R
authors: Aslebagh
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Devika
authors: D
authors: Channaveerappa
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Emmalyn J
authors: EJ
authors: Dupree
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Megan M
authors: MM
authors: Borland
authors: Department of Psychology, SUNY Plattsburgh, Plattsburgh, NY, USA.
authors: Jeanne P
authors: JP
authors: Ryan
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
authors: Costel C
authors: CC
authors: Darie
authors: Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.|Center for Neurobehavioral Health, SUNY Plattsburgh, Plattsburgh, NY, USA.
authors: Alisa G
authors: AG
authors: Woods
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D009462:Neurology / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D011570:Psychiatry / Q000379:methods*; D012463:Saliva / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Proteomics