title: Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion.
abstract: OBJECTIVE
  Our aim was to compare the 1 year efficacy and safety results of intravitreal bevacizumab (IVB) in two prospective, consecutive groups of patients with macular edema (ME) following branch retinal vein occlusion (BRVO).
  
  
  METHODS
  Twenty-five eyes with ME after BRVO received one IVB injection (single-injection group) and 27 eyes received three monthly IVB injections (three-injection group). Both groups were followed monthly for 12 months. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Patients were eligible to receive an IVB injection if the mean CFT increased 100 μm or more or the BCVA decreased 0.1 logarithm of the minimum angle of resolution (logMAR) unit or more compared with values measured on the last visit.
  
  
  RESULTS
  The mean logMAR BCVA and CFT, respectively, improved from 0.56 to 0.33 and from 598 μm to 348 μm in the single-injection group (P<0.001) and from 0.55 to 0.26 and from 514 μm to 293 μm in the three-injection group (P<0.001). During the study period, the mean total number of injections was significantly smaller in the single-injection group than in the three-injection group (2.1 and 4.3, respectively, P<0.001). No serious complications related to the IVB injections developed in either group.
  
  
  CONCLUSIONS
  The single-injection group achieved similar visual outcomes for ME secondary to BRVO with fewer injections compared with the three-injection group.
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Yuka
authors: Y
authors: Ito
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Yoshitsugu
authors: Y
authors: Saishin
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Osamu
authors: O
authors: Sawada
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Masashi
authors: M
authors: Kakinoki
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Taichiro
authors: T
authors: Miyake
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Tomoko
authors: T
authors: Sawada
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Hajime
authors: H
authors: Kawamura
authors: Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
authors: Masahito
authors: M
authors: Ohji
keywords: bevacizumab; branch retinal vein occlusion; single intravitreal injection; three monthly intravitreal injections
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