title: Comparative endoscopic evaluation of normal and ulcerated gastric mucosae in Thoroughbred foals.
abstract: To contribute to early diagnosis and treatment of gastric ulcer of foals, we examined the gastric mucosa of healthy and affected foals using an endoscope. In healthy foals, the characteristic changes in the development of the squamous mucosa were seen mainly in the squamous mucosa, and maturation of the squamous mucosa in the greater curvature (GC-S) occurred more slowly than that of the squamous mucosa in the lesser curvature (LC-S). Epithelial desquamation in the LC-S and GC-S was observed between 6 and 90 days but was not observed in the LC-S at about 60 days, whereas it was observed in the GC-S until 90 days old. These findings suggest that there is a difference in the development of the gastric mucosa by region and that desquamation continues over a term longer than studies have reported in the past. In the affected foals, the minimum age at which gastric ulcer was observed was 4 days old. Gastric ulcers formed predominantly in the squamous mucosa (LC-S and GC-S) of foals with an immature mucosa before the weaning period, and the peak incidence occurred between 61 and 90 days old. The differences in the ulceration sites were considered to depend on the difference in the development (maturation) stage of the squamous mucosa. The grading score of the gastric ulcer increased with the growth of the affected foals. The gastric ulcer might be enhanced greatly by stress in the weaning period.
authors: Okai. Vet. Service, 7-54 Hokuseicho, Niikappu; Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
authors: Kazuhiko
authors: K
authors: Okai
authors: Sadao
authors: S
authors: Taharaguchi
authors: Yasuhiro
authors: Y
authors: Orita
authors: Hiroshi
authors: H
authors: Yokota
authors: Hiroyuki
authors: H
authors: Taniyama
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D016022:Case-Control Studies; D016099:Endoscopy, Gastrointestinal / Q000662:veterinary*; D005753:Gastric Mucosa / Q000473:pathology*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D013276:Stomach Ulcer / Q000473:pathology / Q000662:veterinary*
references: Equine Vet J Suppl. 1999 Apr;(29):14-8
references: 10696287
references: Equine Vet J Suppl. 1999 Apr;(29):30-3
references: 10696290
references: J Am Vet Med Assoc. 1989 Oct 15;195(8):1135-41
references: 2808108
references: Equine Vet J. 1990 Jan;22(1):6-8
references: 2298194
references: J Vet Med Sci. 1991 Dec;53(6):1079-80
references: 1790219
references: Am J Vet Res. 1992 Oct;53(10):1729-31
references: 1456509
references: Equine Vet J. 1993 Nov;25(6):514-7
references: 8275998