title: Allogeneic cardiac stem cell administration for acute myocardial infarction.
abstract: Myocardial infarction, even after reperfusion, leads to significant loss of cardiomyocytes and to a maladaptive remodeling process. A possibility gaining attention as an ancillary therapy is the use of cardiac-derived cell products, with early stage clinical trials reporting highly promising results with autologous cells. However, an autologous therapy presents limitations, such as timeframe of therapy, cell processing and culture costs, risks posed to the patient by the tissue harvesting, etc. Allogeneic cells may represent an answer, providing an off-the-shelf product that could be used in the acute stage, before the myocardial damage is irrevocable. To date, allogeneic cardiac-derived cell products are being tested extensively, but the questions of their immunogenicity (and therefore safety), efficacy, cost-effectiveness, etc. are only partially elucidated. Small Phase I/II clinical trials (ALLSTAR, CAREMI) have started and their results will shed the much needed light on the feasibility and safety of a much needed therapy.
authors: Jesús Usón Minimally Invasive Surgery Centre, Carretera N-521, km 41.8, 10071 - Cáceres, Spain.
authors: Veronica
authors: V
authors: Crisostomo
authors: Javier G
authors: JG
authors: Casado
authors: Claudia
authors: C
authors: Baez-Diaz
authors: Rebeca
authors: R
authors: Blazquez
authors: Francisco M
authors: FM
authors: Sanchez-Margallo
mesh_terms: D000818:Animals; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000473:pathology; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors; D014184:Transplantation, Homologous
keywords: allogeneic; animal models; cardiac stem cells; experimental therapy; myocardial infarction; myocardial regeneration