title: 1064 nm long-pulsed Nd:YAG laser treatment of basal cell carcinoma.
abstract: OBJECTIVE
  Standard surgical and destructive treatments for basal cell carcinoma (BCC) can result in significant morbidity and scarring, stimulating the investigation of alternative non-surgical options. The objective of this study was to determine the safety, clinical, and histological efficacy of pulsed, high-fluence 1064 nm Nd:YAG laser therapy for the treatment of BCC on the trunk and extremities.
  
  
  METHODS
  This was a prospective, non-randomized, open-label clinical trial. Ten subjects with a biopsy-proven BCC less than 1.5 cm in diameter on the trunk or extremities received one treatment with a 10 milliseconds pulsed 1064 nm Nd:YAG laser. Standard excision was performed 1 month after laser treatment to confirm histologic clearance.
  
  
  RESULTS
  The laser treatment was quick and well tolerated. There was complete histologic clearance after one treatment in 92% of the BCC tumors, overall. At higher fluences, there was 100% histologic clearance after one treatment. No significant adverse events were seen, including scarring.
  
  
  CONCLUSIONS
  The 1064 nm long-pulsed Nd:YAG laser may offer a safe alternative for treating BCC off the face. A larger study is highly warranted to confirm these preliminary results. Lasers Surg. Med. 47:106-110, 2015. © 2015 Wiley Periodicals, Inc.
authors: Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114; Wellman Center for Photomedicine, Boston, Massachusetts, 02114; UC San Diego, San Diego, California, 92122.
authors: Arisa E
authors: AE
authors: Ortiz
authors: R Rox
authors: RR
authors: Anderson
authors: Mathew M
authors: MM
authors: Avram
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: BCC; laser therapy; laser treatment; nonmelanoma skin cancer; skin cancer