title: High serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients.
abstract: Previous studies have shown that some microRNAs (miRs) are intensively involved in the development of hepatocellular carcinoma. We analyzed the prognostic role of serum microRNA (miR-122) levels in hepatocellular carcinoma patients using a retrospective design. MiR-122 levels in 122 hepatocellular carcinoma patients were measured, and Cox regression analysis was performed to analyze the prognostic role of miR-122 in hepatocellular carcinoma, and the hazard ratio (HR) with 95 % confidence interval (95 %CI) was used to evaluate its prognostic role. Patients with large tumor size had lower levels of serum miR-122 (P = 0.04). However, there was no significant association of serum miR-122 levels with other clinical characteristics. Kaplan-Meier method showed that there was higher overall survival rate in hepatocellular carcinoma patients with high serum miR-122 levels compared with those with low miR-122 level (P < 0.01). When using Cox regression analysis, high serum miR-122 level was independently associated with better overall survival in hepatocellular carcinoma patients (HR = 0.26; 95 %CI 0.14-0.47, P < 0.01). Subgroup analysis by gender showed that high serum miR-122 level was independently associated with better overall survival in male patients (HR = 0.08; 95 %CI 0.03-0.22, P < 0.01), but not in female patients (HR = 0.48; 95 %CI 0.18-1.32, P = 0.16). Thus, the outcomes in the analysis suggest that high serum miR-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients, and it is a good biomarker of better prognosis in patients with hepatocellular carcinoma.
authors: Department of Hepatobiliary and Spleen Surgery, Shengjing Hospital of China Medical University, Shenyang, 100004, China.
authors: Yongqing
authors: Y
authors: Xu
authors: Xianmin
authors: X
authors: Bu
authors: Chaoliu
authors: C
authors: Dai
authors: Chao
authors: C
authors: Shang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000235:genetics* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C531907:MIRN122 microRNA, human; D035683:MicroRNAs
references: Lancet Diabetes Endocrinol. 2014 Nov;2(11):911-22
references: 24731666
references: J Natl Cancer Inst. 2014 Sep 12;106(10):null
references: 25217579
references: Virol J. 2014 Apr 01;11:64
references: 24690114
references: Liver Int. 2012 May;32(5):752-60
references: 22276989
references: J Virol. 2013 Feb;87(4):2193-205
references: 23221562
references: Lancet Diabetes Endocrinol. 2014 Apr;2(4):307-20
references: 24703049
references: Nat Rev Mol Cell Biol. 2014 Sep;15(9):565-76
references: 25118717
references: Trends Mol Med. 2014 Aug;20(8):460-9
references: 25027972
references: Virology. 2013 Feb 5;436(1):179-90
references: 23245472
references: Nat Rev Mol Cell Biol. 2014 Aug;15(8):509-24
references: 25027649
references: PLoS One. 2011;6(12):e28486
references: 22174818
references: J Clin Invest. 2012 Aug;122(8):2884-97
references: 22820290
references: Hepat Mon. 2014 Aug 01;14(8):e18672
references: 25337143
references: Surg Oncol Clin N Am. 2015 Jan;24(1):1-17
references: 25444466
references: PLoS One. 2012;7(9):e45652
references: 23029162
references: Science. 2010 Jan 8;327(5962):198-201
references: 19965718
references: Lancet Diabetes Endocrinol. 2014 Nov;2(11):901-10
references: 24731669
references: RNA Biol. 2012 Feb;9(2):137-42
references: 22258222
references: Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):843-53
references: 25260312
references: Eur J Cancer. 2013 Nov;49(16):3442-9
references: 23810247
references: Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):753-70
references: 25260306
references: J Hepatol. 2014 Nov;61(1 Suppl):S79-90
references: 25443348
references: Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):937-47
references: 25260319
references: Hepatology. 2014 Nov;60(5):1767-75
references: 24839253
references: Lancet Diabetes Endocrinol. 2013 Oct;1(2):132-9
references: 24622319