title: Familial Mediterranean Fever.
abstract: Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on short arm of Chromosome 16. The disease is diagnosed based on clinical evaluation. Amyloidosis is the most important complication. The only agent that decreases the development of amyloidosis and the frequency and severity of the episodes is colchicine, which has been used for about 40 years. In this review, we aimed to discuss especially the most recent advances about Familial Mediterranean Fever which is commonly seen in our population.
authors: Necmettin Erbakan Üniversitesi Romatoloji Bilim Dalı Konya,Turkey.
authors: Adem
authors: A
authors: Kucuk
authors: Eğitim ve Araştırma Hastanesi Fiziksel Tıp ve Rehabilitasyon Bölümü Konya, Turkey.
authors: Ilknur Albayrak
authors: IA
authors: Gezer
authors: Konya Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği, Konya, Turkey.
authors: Ramazan
authors: R
authors: Ucar
authors: Devlet Hastanesi Fiziksel Tıp ve Rehabilitasyon Bölümü Konya, Turkey.
authors: Ali Yavuz
authors: AY
authors: Karahan
mesh_terms: D000686:Amyloidosis / Q000209:etiology*; D003078:Colchicine / Q000627:therapeutic use*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D011379:Prognosis; D000071198:Pyrin; D050257:Tubulin Modulators / Q000627:therapeutic use
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D050257:Tubulin Modulators; D003078:Colchicine