title: Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease.
abstract: In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
authors: Giulia
authors: G
authors: Nato
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
authors: Alessia
authors: A
authors: Caramello
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
authors: Sara
authors: S
authors: Trova
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
authors: Valeria
authors: V
authors: Avataneo
authors: Departement of Biomedecin, University of Basel, Basel 4050, Switzerland.
authors: Chiara
authors: C
authors: Rolando
authors: Departement of Biomedecin, University of Basel, Basel 4050, Switzerland.
authors: Verdon
authors: V
authors: Taylor
authors: Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin 10126, Italy.
authors: Annalisa
authors: A
authors: Buffo
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy paolo.peretto@unito.it federico.luzzati@unito.it.
authors: Paolo
authors: P
authors: Peretto
authors: Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy paolo.peretto@unito.it federico.luzzati@unito.it.
authors: Federico
authors: F
authors: Luzzati
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism; D000089622:Doublecortin Domain Proteins; D005455:Fluorescent Antibody Technique; D006816:Huntington Disease / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism
chemical_list: D000089622:Doublecortin Domain Proteins; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides
keywords: Huntington's disease; Lesion-induced neurogenesis; Mouse; Neural stem cells; Parenchymal progenitors; Stem cell quiescence