title: Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient.
abstract: Cytomegalovirus (CMV) is a significant cause of morbidity, mortality and graft loss in solid organ transplantation (SOT). Treatment options for ganciclovir-resistant CMV are limited. We describe a case of ganciclovir-resistant CMV disease in a renal transplant recipient manifested by thrombotic microangiopathy-associated glomerulopathy. Adoptive T cell immunotherapy using CMV-specific T cells from a donor bank was used as salvage therapy. This report is a proof-of-concept of the clinical and logistical feasibility of this therapy in SOT recipients.
authors: Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia.
authors: N
authors: N
authors: Macesic
authors: D
authors: D
authors: Langsford
authors: K
authors: K
authors: Nicholls
authors: P
authors: P
authors: Hughes
authors: D J
authors: DJ
authors: Gottlieb
authors: L
authors: L
authors: Clancy
authors: E
authors: E
authors: Blyth
authors: K
authors: K
authors: Micklethwaite
authors: B
authors: B
authors: Withers
authors: S
authors: S
authors: Majumdar
authors: S
authors: S
authors: Fleming
authors: J
authors: J
authors: Sasadeusz
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000628:therapy*; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D016219:Immunotherapy, Adoptive; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir
keywords: antibiotic drug resistance; antibiotic: antiviral-ganciclovir/valganciclovir; clinical research/practice; infection and infectious agents; infectious disease; kidney transplantation/nephrology; viral: Cytomegalovirus (CMV)