title: BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.
abstract: Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer's disease. Alzheimer's disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer's disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer's disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer's disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.
authors: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. GAH00635@nifty.com.
authors: Atsuko
authors: A
authors: Nakanishi
authors: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. laa_minami@cc.nara-wu.ac.jp.
authors: Akari
authors: A
authors: Minami
authors: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. y_kitagishi@live.jp.
authors: Yasuko
authors: Y
authors: Kitagishi
authors: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. pl0okm9ijn@live.jp.
authors: Yasunori
authors: Y
authors: Ogura
authors: Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. smatsuda@cc.nara-wu.ac.jp.
authors: Satoru
authors: S
authors: Matsuda
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D019313:BRCA1 Protein / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D019313:BRCA1 Protein; D016159:Tumor Suppressor Protein p53
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