title: Dynamic synchronization of ongoing neuronal activity across spinal segments regulates sensory information flow.
abstract: Previous studies on the correlation between spontaneous cord dorsum potentials recorded in the lumbar spinal segments of anaesthetized cats suggested the operation of a population of dorsal horn neurones that modulates, in a differential manner, transmission along pathways mediating Ib non-reciprocal postsynaptic inhibition and pathways mediating primary afferent depolarization and presynaptic inhibition. In order to gain further insight into the possible neuronal mechanisms that underlie this process, we have measured changes in the correlation between the spontaneous activity of individual dorsal horn neurones and the cord dorsum potentials associated with intermittent activation of these inhibitory pathways. We found that high levels of neuronal synchronization within the dorsal horn are associated with states of incremented activity along the pathways mediating presynaptic inhibition relative to pathways mediating Ib postsynaptic inhibition. It is suggested that ongoing changes in the patterns of functional connectivity within a distributed ensemble of dorsal horn neurones play a relevant role in the state-dependent modulation of impulse transmission along inhibitory pathways, among them those involved in the central control of sensory information. This feature would allow the same neuronal network to be involved in different functional tasks.
authors: Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies of the Instituto Politécnico Nacional, México.
authors: E
authors: E
authors: Contreras-Hernández
authors: Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies of the Instituto Politécnico Nacional, México.
authors: D
authors: D
authors: Chávez
authors: Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies of the Instituto Politécnico Nacional, México.|El Colegio Nacional, México.
authors: P
authors: P
authors: Rudomin
mesh_terms: D000818:Animals; D002415:Cats / Q000502:physiology*; D003344:Cortical Synchronization / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D053444:Inhibitory Postsynaptic Potentials; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology; D010812:Physical Stimulation; D020671:Posterior Horn Cells / Q000502:physiology*; D066191:Sensorimotor Cortex / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000502:physiology*; D012867:Skin / Q000294:innervation; D013314:Stress, Mechanical
references: Neural Plast. 2012;2012:797295
references: 23213574
references: Eur J Neurosci. 2012 Dec;36(11):3500-8
references: 22967006
references: Nature. 2014 May 1;509(7498):43-8
references: 24784215
references: J Physiol. 2013 May 15;591(10):2629-45
references: 23478136
references: J Neurosci. 2009 Oct 14;29(41):12807-14
references: 19828793
references: J Physiol. 2001 May 15;533(Pt 1):5-13
references: 11351007
references: Trends Cogn Sci. 2005 Oct;9(10):474-80
references: 16150631
references: Neuroscience. 2006 Sep 29;142(1):203-21
references: 16876327
references: Neuroscience. 1997 Jan;76(1):39-54
references: 8971757
references: Exp Brain Res. 2003 Feb;148(3):401-13
references: 12541150
references: Pain. 2013 Dec;154(12):2606-15
references: 23707280
references: J Physiol. 2010 Jun 15;588(Pt 12):2077-90
references: 20403979
references: J Neurophysiol. 1972 Jan;35(1):44-64
references: 4332853
references: Q J Exp Physiol. 1982 Apr;67(2):193-212
references: 6281848
references: Neurosci Lett. 1996 Dec 6;220(1):25-8
references: 8977140
references: Arch Ital Biol. 2007 Nov;145(3-4):235-50
references: 18075118
references: J Physiol. 2012 Aug 15;590(16):3927-51
references: 22674718
references: J Comp Neurol. 2004 Dec 20;480(4):364-77
references: 15558798
references: J Physiol. 2009 Feb 15;587(Pt 4):713-9
references: 19218620
references: J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):473-7
references: 12397137
references: Phys Rev Lett. 2013 Apr 26;110(17):178101
references: 23679783
references: Dev Neurobiol. 2008 May;68(6):788-803
references: 18383543
references: Prog Neurobiol. 2005 Jul;76(4):213-35
references: 16280194
references: J Neurophysiol. 1975 Jan;38(1):19-25
references: 162943
references: Exp Brain Res. 1999 Oct;128(3):263-77
references: 10501799
references: Nature. 2014 Feb 13;506(7487):150-2
references: 24522584
references: Neural Comput. 1999 Oct 1;11(7):1537-51
references: 10490937
references: Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15085-90
references: 23980180
references: J Physiol. 2009 Jan 15;587(2):379-99
references: 19047211
references: J Neurophysiol. 1981 Sep;46(3):506-16
references: 7299431
references: Exp Brain Res. 2007 Jan;176(1):98-118
references: 16896983
references: Science. 2007 Jun 15;316(5831):1609-12
references: 17569862
references: J Physiol. 2012 Apr 1;590(7):1563-84
references: 22271870
references: Front Comput Neurosci. 2014 Apr 29;8:49
references: 24808854
references: J Neurophysiol. 1984 Sep;52(3):449-58
references: 6090609
references: Network. 1998 Nov;9(4):R53-78
references: 10221571
references: J Neurophysiol. 1990 Jan;63(1):147-60
references: 2299379
references: Acta Physiol Scand. 1961 Jan;51:1-16
references: 13764293
references: J Neurophysiol. 1975 Jan;38(1):1-9
references: 1089136
references: Eur J Neurosci. 1997 May;9(5):1017-25
references: 9182954
references: J Neural Eng. 2012 Oct;9(5):056009
references: 22929924
references: J Physiol. 2000 Dec 1;529 Pt 2:445-60
references: 11101653
references: J Neurosci. 2006 Mar 15;26(11):2871-80
references: 16540564
references: Neuron. 2014 Jan 8;81(1):120-9
references: 24411736
references: Curr Opin Neurobiol. 1995 Apr;5(2):239-47
references: 7620313
references: PLoS One. 2011;6(10):e26449
references: 22046288
references: Nature. 2012 Dec 13;492(7428):180-1
references: 23235861
references: Brain Res Rev. 2008 Jan;57(1):77-85
references: 17920131
references: J Neurophysiol. 1987 May;57(5):1288-313
references: 3585469