title: Two new pyrrolosesquiterpenes produced by a Streptomyces species.
abstract: Two new pyrrolosesquiterpenes, 1 and 2, were isolated from cultures of the soil actinomycete Streptomyces sp. Hd7-21. The structures of these compounds were established as (2Z,4E,9E)-6,7,11-trihydroxy-3,7,11-trimethyl-1-(1H-pyrrol-2-yl)dodeca-2,4,9-trien-1-one (1) and (2Z,4E)-5-{3-[(2E)-4-hydroxy-4-methylpent-2-en-1-yl]-3-methyloxiran-2-yl}-3-methyl-1-(1H-pyrrol-2-yl)penta-2,4-dien-1-one (2) by extensive spectroscopic analyses including MS, and 1D- and 2D-NMR data. Their cytotoxic activities against a panel of human cancer cell lines were evaluated.
authors: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China. liudongze0923@sina.com.
authors: Dong-Ze
authors: DZ
authors: Liu
authors: Bo-Wen
authors: BW
authors: Liang
authors: Xiao-Fei
authors: XF
authors: Li
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes
keywords: Actinomycetes; Cytotoxic activity; Pyrrolo-sesquiterpenes; Sesquiterpenes