title: A porphyrin-inspired iron catalyst for asymmetric epoxidation of electron-deficient olefins.
abstract: An in situ formed porphyrin-inspired iron complex that catalyzes asymmetric epoxidation of di- and trisubstituted enones is described. The reaction provides highly enantioenriched α,β-epoxyketones (up to 99% ee). The practical utility of the new catalyst system is demonstrated by the gram-scale synthesis of optically pure epoxide. Hammett analysis suggests that the transition state of the reaction is electron-demanding and the active oxidant is electrophilic.
authors: Dalian Institute of Chemical Physics, the Chinese Academy of Sciences , Dalian, 116023, People's Republic of China.
authors: Wen
authors: W
authors: Dai
authors: Guosong
authors: G
authors: Li
authors: Bo
authors: B
authors: Chen
authors: Lianyue
authors: L
authors: Wang
authors: Shuang
authors: S
authors: Gao