title: Risk assessment of second primary cancer according to histological subtype of non-Hodgkin lymphoma.
abstract: Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of diseases that are known to carry a considerable risk of second primary cancer (SPC). However, little attention has been paid to SPC risk assessment according to NHL subtypes. Data from 10 French population-based cancer registries were used to establish a cohort of 7546 patients with a first diagnosis of NHL (eight subtypes) between 1989 and 2004. Standardized incidence ratios (SIRs) of metachronous SPC were estimated. Among the 7546 patients diagnosed with a NHL, the overall SPC risk was 25% higher than that in the reference population (SIR = 1.25, 95% confidence interval 1.15-1.36). In univariate analysis, the SPC risk differed by lymphoma subtype. Interestingly, multivariate analysis showed that SPC risk did not differ significantly across NHL subtypes after adjustment for the other covariates (p = 0.786). Patients with NHL have an increased risk of SPC that is not influenced by the histological NHL subtype.
authors: a Hématologie Clinique , CHU Le Bocage, Dijon , France.|b Hematology Laboratory, University Hospital of Dijon , Dijon , France.
authors: Cédric
authors: C
authors: Rossi
authors: c Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg , Strasbourg , France.|d Service de santé publique, Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|e Service d'épidémiologie et de biostatistiques, Centre Paul Strauss , Strasbourg , France.|f Francim: Réseau français des registres des cancers , France.
authors: Jérémie
authors: J
authors: Jégu
authors: g Registre des hémopathies malignes de Côte d'Or, EA4184, Université de Bourgogne , Dijon , France.
authors: Morgane
authors: M
authors: Mounier
authors: g Registre des hémopathies malignes de Côte d'Or, EA4184, Université de Bourgogne , Dijon , France.
authors: Mylène
authors: M
authors: Dandoit
authors: f Francim: Réseau français des registres des cancers , France.|h Registre des cancers de l'Isère, CHU de Grenoble , Grenoble , France.
authors: Marc
authors: M
authors: Colonna
authors: f Francim: Réseau français des registres des cancers , France.|i Registre des cancers du Tarn , Albi , France.|j Institut Claudius Regaud , Toulouse , France.
authors: Laetitia
authors: L
authors: Daubisse-Marliac
authors: f Francim: Réseau français des registres des cancers , France.|k Registre des tumeurs de l'Hérault, Centre de Recherche , Montpellier , France.
authors: Brigitte
authors: B
authors: Trétarre
authors: f Francim: Réseau français des registres des cancers , France.|l Registre des cancers de la Somme, Service Épidémiologie Hygiène et Santé Publique , CHU Nord, Amiens , France.
authors: Olivier
authors: O
authors: Ganry
authors: f Francim: Réseau français des registres des cancers , France.|m Registre général des tumeurs du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse , Caen , France.
authors: Anne-Valérie
authors: AV
authors: Guizard
authors: f Francim: Réseau français des registres des cancers , France.|n Registre des cancers de la Manche, Centre Hospitalier Public du Cotentin , Cherbourg-Octeville , France.
authors: Simona
authors: S
authors: Bara
authors: f Francim: Réseau français des registres des cancers , France.|o Registre des tumeurs digestives du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse , Caen , France.
authors: Véronique
authors: V
authors: Bouvier
authors: f Francim: Réseau français des registres des cancers , France.|p Registre des tumeurs du Doubs et du Territoire de Belfort, EA3181, Centre Hospitalier Régional Universitaire Saint-Jacques , Besançon , France.
authors: Anne-Sophie
authors: AS
authors: Woronoff
authors: f Francim: Réseau français des registres des cancers , France.|q Registre des hémopathies malignes de la Gironde , France.
authors: Alain
authors: A
authors: Monnereau
authors: a Hématologie Clinique , CHU Le Bocage, Dijon , France.
authors: Olivier
authors: O
authors: Casasnovas
authors: c Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg , Strasbourg , France.|d Service de santé publique, Hôpitaux Universitaires de Strasbourg , Strasbourg , France.|e Service d'épidémiologie et de biostatistiques, Centre Paul Strauss , Strasbourg , France.|f Francim: Réseau français des registres des cancers , France.
authors: Michel
authors: M
authors: Velten
authors: f Francim: Réseau français des registres des cancers , France.|r Registre des hémopathies malignes de Basse-Normandie, Unité Fonctionnelle Hospitalo-Universitaire n° 0350, Centre Hospitalier Universitaire , Caen , France.
authors: Xavier
authors: X
authors: Troussard
authors: b Hematology Laboratory, University Hospital of Dijon , Dijon , France.|f Francim: Réseau français des registres des cancers , France.|g Registre des hémopathies malignes de Côte d'Or, EA4184, Université de Bourgogne , Dijon , France.
authors: Marc
authors: M
authors: Maynadié
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D011159:Population Surveillance; D012042:Registries; D018570:Risk Assessment; D055815:Young Adult
keywords: Non-Hodgkin lymphoma; epidemiology; risk assessment; second cancer