title: Copper-catalyzed ring expansion of 2-aminobenzothiazoles with alkynyl carboxylic acids to 1,4-benzothiazines.
abstract: A new ring expansion of 2-aminobenzothiazoles with alkynyl carboxylic acids was developed, which allows for one-pot synthesis of 1,4-benzothiazines in moderate to excellent yields. The cascade reaction was achieved through decarboxylative coupling, nucleophilic ring-opening reaction and intramolecular hydroamination process.
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China. zxg@wzu.edu.cn.
authors: Jing-Wen
authors: JW
authors: Qiu
authors: Bo-Lun
authors: BL
authors: Hu
authors: Xing-Guo
authors: XG
authors: Zhang
authors: Ri-Yuan
authors: RY
authors: Tang
authors: Ping
authors: P
authors: Zhong
authors: Jin-Heng
authors: JH
authors: Li
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013843:Thiazines / Q000138:chemical synthesis*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: C446962:1,4-benzothiazine; D002264:Carboxylic Acids; D012997:Solvents; D013843:Thiazines; D013844:Thiazoles; D003300:Copper