title: Celiac disease prevalence in the patients with irritable bowel syndrome in the ilam province; a cross sectional study from Western iran.
abstract: BACKGROUND
  Many studies have shown that the prevalence of celiac disease (CD) is increasing in the patients with irritable bowel syndrome (IBS), but the present evidences are controversy and all of the researches don't suggest evaluation of the patients with IBS for the CD.
  
  
  METHODS
  In the cross-sectional study, 1000 patients that affected by IBS with the predominant feature of diarrhea who referred to the gastroenterology clinic were evaluated during 2009-2012 years. Blood samples were taken from the patients for ELISA of IgA tissue transglutaminase (TTG) Ab. Then biopsy was taken from the second part of duodenum of all of patients by endoscopy and the sample was referred to pathologist for histopathology evaluation in order to confirm diagnosis.
  
  
  RESULTS
  About half of the patients with IBS were women (50.3%) and the mean age ± Standard deviation of the men and women was 29.59±11.41 and 28.42±11.73, respectively. The mean titer of TTG IgA Ab in the women and men affected by IBS was 5.25±17.77 and 7.22±25.4, respectively. Seventy six cases (7.6%) that affected by IBS had high serum level of Ab titer (TTG IgA.Ab≥10) that including 41 women and 35 men. In the patients with high serum level of Ab titer, 57 cases (75%) were affected by celiac disease (based on histopathology report). Therefore, the prevalence of CD was 5.7% among patients with IBS.
  
  
  CONCLUSIONS
  In the current study the incidence of CD was evaluated 5.7 cases per each 100 people with IBS. It's suggested that all of the patients with diarrhea predominant IBS and high serum level of TTG IgA Ab must be examined for evaluation of CD.
authors: Student Research Committee, Ilam University of Medical Sciences , Ilam, Iran .
authors: Alireza
authors: A
authors: Mahmoodi
authors: Assistant Professor of Gastroenterology, Dept of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences , Ilam, Iran .
authors: Ali
authors: A
authors: Jafarihaydarlo
authors: Student Research Committee, Ilam University of Medical Sciences , Ilam, Iran .
authors: Masood
authors: M
authors: Yasemi
authors: Assistant Professor of Anesthesia, Department of Anesthesiology, Faculty of Medicine, Ilam University of Medical Sciences , Ilam, Iran .
authors: Karim
authors: K
authors: Hemati
authors: Student Research Committee, Ilam University of Medical Sciences , Ilam, Iran .
authors: Hadi
authors: H
authors: Peyman
keywords: Celiac disease (CD); Diarrhea; Ilam; Irritable bowel syndrome (IBS)
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