title: Therapeutic effects of 5-fluorouracil sustained-release particles in 81 malignant pericardial effusion patients.
abstract: This study aimed to investigate the clinical application value of the 5-fluorouracil (5-FU) sustained-release particles implanted along the cardiac tangent direction into malignant pericardial effusion (MPCE). A total of 81 MPCE patients underwent pericardiocentesis, and were implanted with 5-FU sustained-release particles into the pericardial cavity under ultrasound guidance. The puncturing path was along the cardiac tangent direction. Ultrasound examinations were performed every week, and the efficacy was evaluated 4 weeks after treatment. The 45 patients who were treated with pericardial catheter drainage and simultaneous intracavitary chemotherapy were used as the control group. The success rate of pericardiocentesis was 100%. Ultrasound reviews performed 4 weeks after treatment showed that 71 cases achieved complete remission and eight cases achieved partial remission, while treatment was completely ineffective in two cases. The total remission rate was 97.53%, which was significantly higher than that of the control group (77.78%, p < 0.01). The implantation of 5-FU sustained-release particles along the cardiac tangent direction was safe, and demonstrated good efficacy and fewer adverse reactions. Thus, this method could be ideal for the treatment of MPCE.
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Yong-Li
authors: YL
authors: Ji
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Rui-Zhi
authors: RZ
authors: Li
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Li-Fang
authors: LF
authors: Xue
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Ping
authors: P
authors: Li
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Xiao-Hong
authors: XH
authors: Liang
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Liang
authors: L
authors: Dong
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Yang
authors: Y
authors: Gao
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China.
authors: Wen-Chao
authors: WC
authors: Cui
authors: Department of Ultrasonography, Shengli Oil Field Center Hospital, Dongying, Shandong Province, China. Electronic address: minxiapang@126.com.
authors: Min-Xia
authors: MX
authors: Pang
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D005472:Fluorouracil
keywords: 5-Fluorouracil sustained-release particles; Cardiac tangent direction; Malignant pericardial effusion; Pericardiocentesis; Ultrasonic interventional therapy
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