title: The effects of low-level laser therapy on orthodontically induced root resorption.
abstract: The aim of this study was to evaluate the preventive and/or reparative effects of low-level laser therapy (LLLT) on orthodontically induced inflammatory root resorption (OIIRR) in rats. Thirty rats were divided into four groups (short-term control (SC), short-term laser (SL), long-term control (LC), long-term laser (LL)). In all groups, the left first molar was moved mesially for 11 days. At the end of this period, the rats in groups SC and SL were killed in order to observe the resorption lacunas and to evaluate whether LLLT had any positive effect on root resorption. The groups LC and LL were remained for a healing period of 14 days in order to observe spontaneous repair of the resorption areas and investigate whether LLLT had reparative effects on root resorption. A Ga-Al-As diode laser (Doris, CTL-1106MX, Warsaw, Poland) with a wavelength of 820 nm was used. In SL group, the first molars were irradiated with the dose of 4.8 J/cm2 (50 mW, 12 s, 0.6 J) on every other day during force application. In LL group, the irradiation period was started on the day of appliance removal and the first molars were irradiated with the dose of 4.8 J/cm2 on every other day for the next 14 days. LLLT significantly increased the number of osteoblasts and fibroblasts, and inflammatory response in SL group in comparison with SC group (P = .001). The amount of resorption did not represent any difference between the two groups (P = .16). In LL group, LLLT significantly increased the number of fibroblasts and decreased the amount of resorption in comparison with LC group (P = .001; P = .02). Both parameters indicating the reparative and the resorptive processes were found to be increased by LLLT applied during orthodontic force load. LLLT applied after termination of the orthodontic force significantly alleyed resorption and enhanced/accelerated the healing of OIIRR. LLLT has significant reparative effects on OIIRR while it is not possible to say that it definitely has a preventive effect.
authors: Department of Orthodontics, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey. burcuk12@yahoo.com.
authors: A Burcu
authors: AB
authors: Altan
authors: Department of Orthodontics, Faculty of Dentistry, Gaziosmanpaşa University, Tokat, Turkey.
authors: A Altug
authors: AA
authors: Bicakci
authors: Department of Orthodontics, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey.
authors: H Ilhan
authors: HI
authors: Mutaf
authors: Department of Histology & Embryology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors: Mahmut
authors: M
authors: Ozkut
authors: Department of Histology & Embryology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors: V Sevinc
authors: VS
authors: Inan
mesh_terms: D000818:Animals; D002452:Cell Count; D007150:Immunohistochemistry; D028022:Low-Level Light Therapy; D008297:Male; D009970:Orthodontics; D010010:Osteoclasts / Q000473:pathology; D053244:Osteoprotegerin / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D017208:Rats, Wistar; D012391:Root Resorption / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand
keywords: Low-level laser therapy; OIIRR; Orthodontic force
references: Angle Orthod. 2008 May;78(3):502-9
references: 18416627
references: Am J Orthod Dentofacial Orthop. 1991 Jan;99(1):35-43
references: 1986524
references: Am J Orthod Dentofacial Orthop. 1997 May;111(5):525-32
references: 9155812
references: J Cell Physiol. 2009 Jun;219(3):553-62
references: 19142866
references: Lasers Med Sci. 2013 Jan;28(1):41-7
references: 22350425
references: Eur J Orthod. 1988 Feb;10 (1):30-8
references: 3162877
references: Am J Orthod Dentofacial Orthop. 2010 Apr;137(4):477-85
references: 20362906
references: Lasers Med Sci. 2003;18(2):89-94
references: 12928818
references: Am J Orthod Dentofacial Orthop. 2006 Apr;129(4):469.e1-32
references: 16627171
references: Acta Odontol Scand Suppl. 1951;6:1-240
references: 14829253
references: Cell. 1997 Apr 18;89(2):309-19
references: 9108485
references: Exp Physiol. 1993 Nov;78(6):721-39
references: 8311941
references: Eur J Orthod. 2006 Jun;28(3):221-40
references: 16687469
references: Eur J Orthod. 1996 Feb;18(1):11-8
references: 8746173
references: Am J Orthod Dentofacial Orthop. 2005 Oct;128(4):497-503
references: 16214633
references: Lasers Med Sci. 2015 Jan;30(1):255-62
references: 25228094
references: Eur J Orthod. 1995 Jun;17(3):189-98
references: 7621920
references: J Dent Res. 2006 Aug;85(8):751-6
references: 16861294
references: Angle Orthod. 2000 Apr;70(2):118-25
references: 10832999
references: Eur J Orthod. 2003 Apr;25(2):199-204
references: 12737218
references: J Dent Res. 2004 Dec;83(12 ):920-5
references: 15557398
references: J Photochem Photobiol B. 1999 Mar;49(1):1-17
references: 10365442
references: Bone Miner. 1994 Jun;25(3):183-98
references: 8086857
references: Eur J Orthod. 2004 Oct;26(5):483-90
references: 15536836
references: J Cell Biochem. 2010 Dec 15;111(6):1445-52
references: 20830741
references: Baillieres Clin Rheumatol. 1993 Oct;7(3):421-43
references: 8293482
references: Am J Orthod Dentofacial Orthop. 2007 Jan;131(1):34-43
references: 17208104
references: Eur J Orthod. 2008 Aug;30(4):336-45
references: 18632841
references: Photomed Laser Surg. 2012 Aug;30(8):460-5
references: 22775467
references: Am J Orthod Dentofacial Orthop. 1996 Sep;110(3):303-10
references: 8814032
references: Am J Orthod Dentofacial Orthop. 2009 Sep;136(3):320.e1-10; discussion 320-1
references: 19732664
references: Eur J Orthod. 2011 Aug;33(4):335-43
references: 20833686
references: Orthod Craniofac Res. 2008 Aug;11(3):143-55
references: 18713151
references: Angle Orthod. 1977 Jan;47(1):1-16
references: 65136
references: J Dent Res. 1987 Aug;66(8):1310-4
references: 3040832
references: Eur J Orthod. 2010 Oct;32(5):496-504
references: 20100785
references: Eur J Orthod. 1995 Jun;17(3):177-88
references: 7542608
references: Eur J Orthod. 2005 Jun;27(3):215-25
references: 15947219
references: Am J Orthod Dentofacial Orthop. 1993 Feb;103(2):120-30
references: 8427216
references: Eur J Oral Sci. 2006 Aug;114(4):318-27
references: 16911103
references: Lasers Med Sci. 2014 Mar;29(2):559-64
references: 23334785
references: Angle Orthod. 1995;65(6):403-8; discussion 409-10
references: 8702065
references: Angle Orthod. 2002 Apr;72(2):175-9
references: 11999941