title: Surgical treatment for nasal polyposis: predictors of outcome.
abstract: Nasal polyps recur in approximately one-third of patients after surgical treatment. It would be beneficial to be able to predict the patients in whom we might expect recurrence and to predict the clinical outcome after surgery. The study included 30 patients operated for nasal polyps. Removed polyps were analyzed by immunohistochemical analysis for IL-5, IgE, vascular endothelial growth factor and eosinophilic infiltration. These parameters together with preoperative CT score were used as independent variables, and subjective score improvement after 2 years was used as a dependent variable in multiple linear regression analysis. Furthermore, the patients were divided into two groups: low and high polyp tissue immunoreactivity. The Chi-squared test was used to determine whether polyp immunoreactivity influences polyp recurrence and subjective score. Preoperative CT score had a slightly positive correlation with subjective score after 2 years. High eosinophil infiltration significantly predicted a higher risk for polyp recurrence. High IL-5 positivity was related to greater risk for polyp recurrence than low IL-5 reactivity but not significantly. IgE and VEGF reactivity in polyp specimens did not have any effect on polyp recurrence. High eosinophilic infiltration in polyps can predict worse outcome after surgical treatment of chronic rhinosinusitis with nasal polyposis. IgE and VEGF do not have prognostic significance to polyp recurrence after surgery. The preoperative extent of disease measured by CT score had a slightly positive correlation with worse outcome after surgery.
authors: Department of ENT and Head and Neck Surgery, 'Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia. marko_grgic@yahoo.com.
authors: Marko Velimir
authors: MV
authors: Grgić
authors: Department of Pathology, University Hospital 'Sisters of Mercy' University Medical Center, Zagreb University School of Dentistry, Vinogradska 29, Zagreb, Croatia.
authors: Hrvoje
authors: H
authors: Ćupić
authors: Department of ENT and Head and Neck Surgery, 'Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia.
authors: Livije
authors: L
authors: Kalogjera
authors: Department of ENT and Head and Neck Surgery, 'Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia.
authors: Tomislav
authors: T
authors: Baudoin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002452:Cell Count; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007150:Immunohistochemistry; D015848:Interleukin-5 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism / Q000601:surgery*; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult
chemical_list: D015848:Interleukin-5; D042461:Vascular Endothelial Growth Factor A; D007073:Immunoglobulin E
keywords: CT score; Eosinophil infiltration; Immunoglobulin E; Interleukin-5; Nasal polyps; Nasal surgical procedures; Vascular endothelial growth factors
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