title: Joint space narrowing, body mass index, and knee pain: the ROAD study (OAC1839R1).
abstract: OBJECTIVE
  The objective of the present study was to clarify the association of joint space narrowing with knee pain in Japanese men and women using a large-scale population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study.
  
  
  METHODS
  This study examined the association between minimum joint space width (mJSW) in the medial compartment and pain at the knee. mJSW was measured in the medial and lateral compartments of the knee using a knee osteoarthritis (OA) computer-aided diagnosis system.
  
  
  RESULTS
  From the 3040 participants in the ROAD study, the present study analyzed 2733 participants who completed the radiographic examinations and questionnaires regarding knee pain (975 men and 1758 women; mean age, 69.9 ± 11.2 years). Subjects with lateral knee OA were excluded. After adjustment for age and Body mass index (BMI), medial mJSW, as well as medial mJSW/lateral mJSW, was significantly associated with knee pain. Sex and BMI affected the association of medial mJSW with knee pain. The threshold of medial mJSW was approximately 3 mm in men and 2 mm in women, while that of medial mJSW/lateral mJSW was approximately 60% in both men and women. BMI was found to have a distinct effect on the association of mJSW with pain.
  
  
  CONCLUSIONS
  The present cross-sectional study using a large-scale population from the ROAD study showed that joint space narrowing had a significant association with knee pain. The thresholds of joint space narrowing for knee pain were also established.
authors: Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan. Electronic address: murakis-ort@h.u-tokyo.ac.jp.
authors: S
authors: S
authors: Muraki
authors: Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
authors: T
authors: T
authors: Akune
authors: Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors: Y
authors: Y
authors: En-Yo
authors: Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors: M
authors: M
authors: Yoshida
authors: National Center for Geriatrics and Gerontology, Aichi, Japan.
authors: T
authors: T
authors: Suzuki
authors: Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors: H
authors: H
authors: Yoshida
authors: Department of Orthopaedic Surgery, Ina Hospital, Saitama, Japan.
authors: H
authors: H
authors: Ishibashi
authors: Department of Orthopaedic Surgery, Tokyo Geriatric Medical Center, Tokyo, Japan.
authors: F
authors: F
authors: Tokimura
authors: Department of Orthopaedic Surgery, Toranomon Hospital, Tokyo, Japan.
authors: S
authors: S
authors: Yamamoto
authors: Department of Orthopaedic Surgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
authors: S
authors: S
authors: Tanaka
authors: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors: K
authors: K
authors: Nakamura
authors: Department of Orthopaedic Surgery, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Tokyo, Japan.
authors: H
authors: H
authors: Kawaguchi
authors: Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: H
authors: H
authors: Oka
authors: Department of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors: N
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D010146:Pain / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D010147:Pain Measurement / Q000379:methods; D011446:Prospective Studies; D011859:Radiography; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
keywords: Cohort study; Epidemiology; Osteoarthritis; Pain