title: Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injury.
abstract: Thermomineral water from the Atomic Spa Gornja Trepča has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neural regeneration-promoting effects after central nervous system injury. In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gornja Trepča on nerve regeneration in a 3-month-old mouse model of spinal cord injury. The mice receiving oral intake of thermomineral water showed better locomotor recovery than those without administration of thermomineral water at 8 and 12 weeks after lower thoracic spinal cord compression. At 12 weeks after injury, sprouting of catecholaminergic axons was better in mice that drank thermomineral water than in those without administration of thermomineral water, but there was no difference in glial reaction to injury between mice with and without administration of thermomineral water. These findings suggest that thermomineral water can promote the nerve regeneration but cannot reduce glial scar formation in a mouse model of spinal cord injury.
authors: Institute of Anatomy "Niko Miljanić", Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Dubravka
authors: D
authors: Aleksić
authors: Institute of Anatomy "Niko Miljanić", Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Milan
authors: M
authors: Aksić
authors: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Nevena
authors: N
authors: Divac
authors: Institute of Anatomy "Niko Miljanić", Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Vidosava
authors: V
authors: Radonjić
authors: Institute of Anatomy "Niko Miljanić", Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Branislav
authors: B
authors: Filipović
authors: Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Igor
authors: I
authors: Jakovčevski
keywords: astrocyte scar; catecholaminergic innervations; lithium; locomotor recovery; magnesium; microglia; nerve regeneration; neuroprotection; spinal cord injury; thermomineral water
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