title: Regulation of cellular innate antiviral signaling by ubiquitin modification.
abstract: Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). Posttranslational modification of proteins by ubiquitin plays an essential role in mediating or regulating the virus-triggered PRRs-mediated signaling. Deubiquitination is the reversible process of ubiquitination and its role in regulating PRRs-mediated signaling has recently been explored. In this review, we first summarize the ubiquitination events in PRRs-mediated signaling that is triggered by viral nucleic acid and then focus on host and viral deubiquitinating enzymes-mediated regulation of virus-triggered signaling that modulates the activation of IRF3 and NF-κB and subsequent induction of type I IFNs.
authors: Department of Oncology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors: Dandan
authors: D
authors: Lin
authors: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China zhongbo@whu.edu.cn.
authors: Bo
authors: B
authors: Zhong
mesh_terms: D054884:Host-Pathogen Interactions / Q000276:immunology / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology*; D050838:Interferon Regulatory Factor-3 / Q000276:immunology / Q000378:metabolism; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000276:immunology / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism; D064570:Ubiquitin-Specific Proteases / Q000276:immunology / Q000378:metabolism; D054875:Ubiquitination / Q000276:immunology*; D014780:Viruses / Q000276:immunology / Q000472:pathogenicity
chemical_list: C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D016328:NF-kappa B; D000069452:Pathogen-Associated Molecular Pattern Molecules; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D064570:Ubiquitin-Specific Proteases
keywords: cellular innate antiviral signaling; pattern-recognition receptor; ubiquitin modification
references: Nat Rev Immunol. 2008 Jul;8(7):559-68
references: 18575461
references: Nature. 2007 Apr 19;446(7138):916-920
references: 17392790
references: PLoS Pathog. 2009 Nov;5(11):e1000650
references: 19893624
references: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51
references: 24706898
references: Science. 2003 Aug 1;301(5633):640-3
references: 12855817
references: Immunity. 2008 Oct 17;29(4):538-50
references: 18818105
references: Nat Immunol. 2010 Nov;11(11):997-1004
references: 20890285
references: PLoS One. 2011 Feb 18;6(2):e17192
references: 21364999
references: Cell Res. 2014 Apr;24(4):400-16
references: 24366338
references: Curr Biol. 2000 Sep 21;10(18):1139-42
references: 10996797
references: Cell Res. 2010 Jul;20(7):802-11
references: 20368735
references: Nat Immunol. 2013 Feb;14(2):172-8
references: 23222971
references: J Biol Chem. 2010 Mar 26;285(13):9470-6
references: 20097753
references: J Exp Med. 2012 Sep 24;209(10):1703-11
references: 22945920
references: Mol Cell. 2005 Sep 16;19(6):727-40
references: 16153868
references: J Biol Chem. 2008 Jul 4;283(27):18621-6
references: 18467330
references: J Exp Med. 2008 Jul 7;205(7):1601-10
references: 18591409
references: Immunity. 2009 Jul 17;31(1):25-34
references: 19576794
references: Nature. 2000 Dec 7;408(6813):740-5
references: 11130078
references: Cell. 2010 Mar 19;140(6):805-20
references: 20303872
references: J Immunol. 2014 May 15;192(10):4758-64
references: 24729608
references: J Virol. 2013 Apr;87(8):4507-15
references: 23388719
references: Nat Immunol. 2009 Dec;10(12):1300-8
references: 19881509
references: Nature. 2006 Jan 12;439(7073):208-11
references: 16306936
references: Immunol Rev. 2012 Mar;246(1):95-106
references: 22435549
references: Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5115-20
references: 23479606
references: Cell. 2005 Sep 9;122(5):669-82
references: 16125763
references: J Immunol. 2009 Oct 1;183(7):4241-8
references: 19734229
references: J Virol. 2014 Nov;88(21):12765-76
references: 25142606
references: J Virol. 2014 Mar;88(6):3103-13
references: 24371060
references: Nature. 2007 Jul 26;448(7152):501-5
references: 17618271
references: Science. 2007 Nov 30;318(5855):1455-8
references: 18048689
references: Mol Immunol. 2011 Jan;48(4):415-22
references: 21156324
references: Nat Immunol. 2012 Mar 04;13(4):387-95
references: 22388039
references: J Virol. 2013 Apr;87(7):4060-70
references: 23365429
references: Nat Rev Mol Cell Biol. 2009 Aug;10(8):550-63
references: 19626045
references: Mol Immunol. 2008 Feb;45(4):1078-84
references: 17719635
references: J Mol Cell Biol. 2011 Oct;3(5):283-92
references: 22028379
references: Cell Res. 2008 Nov;18(11):1096-104
references: 18711448
references: Nature. 2001 Oct 18;413(6857):732-8
references: 11607032
references: Immunity. 2009 Mar 20;30(3):397-407
references: 19285439
references: Cell. 2010 Apr 16;141(2):315-30
references: 20403326
references: J Exp Med. 2004 Jun 21;199(12):1651-8
references: 15210743
references: J Virol. 2011 Apr;85(8):3758-66
references: 21307201
references: Science. 2007 Dec 7;318(5856):1628-32
references: 17991829
references: Mol Cell. 2011 Feb 4;41(3):354-65
references: 21292167
references: J Exp Med. 2000 Aug 21;192(4):595-600
references: 10952730
references: Nature. 2006 Jan 12;439(7073):204-7
references: 16306937
references: Immunity. 2010 Dec 14;33(6):863-77
references: 21167755
references: J Immunol. 2010 Jun 1;184(11):6249-55
references: 20483786
references: Mol Cell. 2014 Apr 24;54(2):289-96
references: 24766893
references: Cell. 2005 Dec 2;123(5):773-86
references: 16325574
references: Mol Cell Biol. 2009 Jun;29(12):3401-12
references: 19380491
references: J Biol Chem. 2013 May 3;288(18):12596-604
references: 23532851
references: Biochem Biophys Res Commun. 2013 Feb 22;431(4):686-92
references: 23357418
references: J Biol Chem. 2012 Aug 17;287(34):28646-55
references: 22745133
references: Sci Signal. 2014 Jan 07;7(307):ra3
references: 24399297
references: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9
references: 15563593
references: J Immunol. 2012 Dec 1;189(11):5304-13
references: 23087404
references: Nat Immunol. 2009 Oct;10(10):1089-95
references: 19734906
references: Nat Immunol. 2005 Oct;6(10):981-8
references: 16127453
references: Science. 2006 Nov 10;314(5801):997-1001
references: 17038589
references: Science. 2013 Feb 15;339(6121):786-91
references: 23258413
references: Nat Immunol. 2004 Jul;5(7):730-7
references: 15208624
references: Cell Res. 2008 Nov;18(11):1105-13
references: 18957937
references: J Virol. 2011 Oct;85(20):10899-904
references: 21835791
references: J Virol. 2012 Jan;86(2):773-85
references: 22072774
references: Science. 2009 Feb 20;323(5917):1070-4
references: 19119185
references: PLoS One. 2012;7(10):e46825
references: 23056470
references: Proc Natl Acad Sci U S A. 2007 May 1;104(18):7500-5
references: 17460044
references: Science. 2013 Feb 15;339(6121):826-30
references: 23258412
references: Immunity. 2014 Apr 17;40(4):515-29
references: 24726876
references: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
references: 20080593
references: Elife. 2013 Aug 14;2:e00785
references: 23951545
references: Nat Immunol. 2002 Feb;3(2):196-200
references: 11812998
references: PLoS Pathog. 2012;8(11):e1003059
references: 23209422
references: Biochem Biophys Res Commun. 2011 Sep 30;413(3):487-93
references: 21910972
references: PLoS One. 2013;8(1):e53717
references: 23308279
references: J Mol Cell Biol. 2014 Apr;6(2):154-63
references: 24755855
references: Nat Immunol. 2009 Oct;10(10):1065-72
references: 19609254
references: PLoS Pathog. 2014 Sep 25;10(9):e1004358
references: 25254379
references: PLoS One. 2009 Jun 01;4(6):e5760
references: 19484123
references: Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11770-5
references: 22745163
references: Nat Immunol. 2009 Jul;10(7):744-52
references: 19483718
references: Nature. 2008 Oct 2;455(7213):674-8
references: 18724357
references: Science. 2006 Nov 10;314(5801):994-7
references: 17038590
references: BMC Biol. 2012 May 24;10:44
references: 22626058
references: Cell. 2013 Jan 31;152(3):467-78
references: 23374343
references: Protein Cell. 2010 Mar;1(3):275-83
references: 21203974
references: J Exp Med. 2014 Feb 10;211(2):313-28
references: 24493797
references: Nat Immunol. 2004 May;5(5):495-502
references: 15107846
references: Cell Host Microbe. 2012 Aug 16;12(2):211-22
references: 22901541
references: Nat Immunol. 2012 Dec;13(12):1155-61
references: 23142775
references: J Virol. 2014 Oct;88(20):11924-32
references: 25100852
references: Cell Host Microbe. 2010 Dec 16;8(6):496-509
references: 21147464
references: Immunity. 2010 Nov 24;33(5):765-76
references: 21074459
references: Cell. 2009 Aug 7;138(3):576-91
references: 19631370
references: J Exp Med. 2004 Jun 21;199(12):1641-50
references: 15210742
references: J Biol Chem. 2010 Feb 12;285(7):4291-7
references: 19996094
references: J Immunol. 2013 Jul 15;191(2):660-9
references: 23772026
references: Nature. 2005 Oct 20;437(7062):1167-72
references: 16177806
references: Cell. 2011 Aug 5;146(3):448-61
references: 21782231