title: The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.
abstract: The KCNQ1 channel (also called Kv7.1 or KvLQT1) belongs to the superfamily of voltage-gated K(+) (Kv) channels. KCNQ1 shares several general features with other Kv channels but also displays a fascinating flexibility in terms of the mechanism of channel gating, which allows KCNQ1 to play different physiological roles in different tissues. This flexibility allows KCNQ1 channels to function as voltage-independent channels in epithelial tissues, whereas KCNQ1 function as voltage-activated channels with very slow kinetics in cardiac tissues. This flexibility is in part provided by the association of KCNQ1 with different accessory KCNE β-subunits and different modulators, but also seems like an integral part of KCNQ1 itself. The aim of this review is to describe the main mechanisms underlying KCNQ1 flexibility.
authors: Department of Physiology and Biophysics, University of Miami, Miami, FL 33136, USA.
authors: Sara I
authors: SI
authors: Liin
authors: Department of Physiology and Biophysics, University of Miami, Miami, FL 33136, USA.
authors: Rene
authors: R
authors: Barro-Soria
authors: Department of Physiology and Biophysics, University of Miami, Miami, FL 33136, USA.
authors: H Peter
authors: HP
authors: Larsson
mesh_terms: D006801:Humans; D015640:Ion Channel Gating; D051657:KCNQ1 Potassium Channel / Q000737:chemistry / Q000502:physiology*
chemical_list: D051657:KCNQ1 Potassium Channel
references: Physiology (Bethesda). 2007 Oct;22:335-41
references: 17928547
references: Nature. 1996 Nov 7;384(6604):80-3
references: 8900283
references: Genomics. 1998 Jul 1;51(1):86-97
references: 9693036
references: Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22710-5
references: 21149716
references: PLoS One. 2008;3(4):e1943
references: 18398469
references: Nature. 1998 Feb 5;391(6667):605-8
references: 9468141
references: Neuron. 1996 Mar;16(3):571-7
references: 8785054
references: Nature. 2000 Jan 20;403(6767):321-5
references: 10659852
references: J Physiol. 2002 Jul 1;542(Pt 1):119-30
references: 12096056
references: J Gen Physiol. 2007 Feb;129(2):121-33
references: 17227916
references: J Gen Physiol. 2008 Jun;131(6):589-603
references: 18504315
references: J Gen Physiol. 2004 Dec;124(6):759-71
references: 15572349
references: Science. 1996 Jan 12;271(5246):213-6
references: 8539623
references: J Mol Cell Cardiol. 2011 Oct;51(4):518-28
references: 21118696
references: Nature. 2007 Nov 15;450(7168):376-82
references: 18004376
references: Proc Natl Acad Sci U S A. 2011 May 31;108(22):9095-100
references: 21576493
references: J Biol Chem. 2012 Oct 5;287(41):34212-24
references: 22908235
references: Neuron. 2010 Sep 23;67(6):915-28
references: 20869590
references: Cell Biochem Biophys. 2008;52(3):149-74
references: 18989792
references: Nat Commun. 2014;5:3750
references: 24769622
references: J Biol Chem. 2011 Feb 11;286(6):4141-9
references: 21118809
references: Nature. 2008 Dec 18;456(7224):891-7
references: 19092925
references: Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17864-9
references: 16314573
references: EMBO J. 2003 Oct 15;22(20):5412-21
references: 14532114
references: J Biol Chem. 2001 Oct 12;276(41):38249-54
references: 11479291
references: J Gen Physiol. 2005 Jan;125(1):71-80
references: 15623896
references: Proc Natl Acad Sci U S A. 2012 May 29;109(22):8552-7
references: 22538811
references: Biophys J. 2002 Oct;83(4):1997-2006
references: 12324418
references: J Biol Chem. 2001 Nov 9;276(45):42268-75
references: 11527966
references: J Biol Chem. 1998 Dec 18;273(51):34069-74
references: 9852064
references: Physiol Rev. 2005 Oct;85(4):1205-53
references: 16183911
references: Channels (Austin). 2013 Nov-Dec;7(6):432-41
references: 23962792
references: Nature. 1996 Nov 7;384(6604):78-80
references: 8900282
references: J Pharmacol Exp Ther. 2003 Dec;307(3):831-8
references: 14561846
references: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):E559-66
references: 23359697
references: Nat Genet. 1997 Feb;15(2):186-9
references: 9020846
references: Front Pharmacol. 2012 Sep 12;3:166
references: 22988442
references: J Gen Physiol. 2007 Sep;130(3):269-81
references: 17698596
references: J Gen Physiol. 1998 Dec;112(6):651-63
references: 9834138
references: Nature. 2000 Jan 13;403(6766):196-9
references: 10646604
references: Annu Rev Physiol. 2000;62:535-72
references: 10845102
references: Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13180-5
references: 23861489
references: Biophys J. 1998 Aug;75(2):785-92
references: 9675180
references: Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):743-8
references: 19131515
references: Front Pharmacol. 2012 Aug 02;3:142
references: 22876232
references: Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R639-48
references: 11832382
references: Nat Genet. 1997 Feb;15(2):181-5
references: 9020845
references: EMBO J. 2000 Dec 1;19(23):6326-30
references: 11101505
references: Nat Genet. 1996 Jan;12(1):17-23
references: 8528244
references: Physiology (Bethesda). 2005 Dec;20:408-16
references: 16287990
references: Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7
references: 20962273
references: J Biol Chem. 2006 Aug 18;281(33):23740-7
references: 16754665
references: J Gen Physiol. 2008 Jan;131(1):59-68
references: 18079560
references: Science. 2002 Jan 18;295(5554):496-9
references: 11799244
references: Front Physiol. 2014 May 27;5:195
references: 24904429
references: Pflugers Arch. 2010 Mar;459(4):521-33
references: 20012478
references: Sci Transl Med. 2012 Apr 25;4(131):131ra50
references: 22539774
references: J Biol Chem. 2010 Mar 5;285(10):7165-75
references: 20051516
references: J Gen Physiol. 1999 Nov;114(5):723-42
references: 10539976
references: Circ Res. 2005 Mar 18;96(5):e25-34
references: 15731462
references: Front Pharmacol. 2012 Jul 27;3:145
references: 22866036
references: J Gen Physiol. 1998 Dec;112(6):665-78
references: 9834139
references: J Gen Physiol. 2002 Jun;119(6):521-32
references: 12034760
references: Neuron. 2004 Jun 24;42(6):927-37
references: 15207237
references: Elife. 2014;3:e03606
references: 25535795
references: Circ Res. 2005 Apr 15;96(7):730-9
references: 15746441
references: Proc Natl Acad Sci U S A. 2012 May 1;109(18):7103-8
references: 22509038
references: EMBO J. 2000 Feb 1;19(3):332-40
references: 10654932
references: Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1438-46
references: 24591645
references: Sci Transl Med. 2009 Oct 14;1(2):2ra6
references: 20368164
references: J Physiol. 2006 Feb 1;570(Pt 3):455-67
references: 16308347
references: Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18922-7
references: 24190995