title: Modification of 1,2,4,5-tetrazine with cationic rhenium(I) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics.
abstract: New phosphorogenic bioorthogonal probes derived from mononuclear and binuclear rhenium(I) polypyridine complexes containing a 1,2,4,5-tetrazine moiety were designed; these complexes displayed substantial dienophile-induced emission enhancement, and accelerated reaction kinetics and could target a protein conjugate in living cells.
authors: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk.
authors: Alex Wing-Tat
authors: AW
authors: Choi
authors: Karson Ka-Shun
authors: KK
authors: Tso
authors: Vicki Man-Wai
authors: VM
authors: Yim
authors: Hua-Wei
authors: HW
authors: Liu
authors: Kenneth Kam-Wing
authors: KK
authors: Lo
mesh_terms: D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D049408:Luminescent Agents / Q000737:chemistry*; D015335:Molecular Probes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D049408:Luminescent Agents; D015335:Molecular Probes; D009942:Organometallic Compounds; D011725:Pyridines; D013777:Tetrazoles; D012211:Rhenium