title: Lesion localization of global aphasia without hemiparesis by overlapping of the brain magnetic resonance images.
abstract: Global aphasia without hemiparesis is a striking stroke syndrome involving language impairment without the typically manifested contralateral hemiparesis, which is usually seen in patients with global aphasia following large left perisylvian lesions. The objective of this study is to elucidate the specific areas for lesion localization of global aphasia without hemiparesis by retrospectively studying the brain magnetic resonance images of six patients with global aphasia without hemiparesis to define global aphasia without hemiparesis-related stroke lesions before overlapping the images to visualize the most overlapped area. Talairach coordinates for the most overlapped areas were converted to corresponding anatomical regions. Lesions where the images of more than three patients overlapped were considered significant. The overlapped global aphasia without hemiparesis related stroke lesions of six patients revealed that the significantly involved anatomical lesions were as follows: frontal lobe, sub-gyral, sub-lobar, extra-nuclear, corpus callosum, and inferior frontal gyrus, while caudate, claustrum, middle frontal gyrus, limbic lobe, temporal lobe, superior temporal gyrus, uncus, anterior cingulate, parahippocampal, amygdala, and subcallosal gyrus were seen less significantly involved. This study is the first to demonstrate the heterogeneous anatomical involvement in global aphasia without hemiparesis by overlapping of the brain magnetic resonance images.
authors: Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea ; Department of Physical Medicine and Rehabilitation, Haeundae Paik Hospital, Inje University of Medicine, Busan, South Korea.
authors: Woo Jin
authors: WJ
authors: Kim
authors: Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea ; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea.
authors: Nam-Jong
authors: NJ
authors: Paik
keywords: brain; global aphasia; global aphasia without hemiparesis; hemiparesis; magnetic resonance imaging; nerve regeneration; neural regeneration; stroke
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