title: Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.
abstract: OBJECTIVE
  The effect of the KIF6 polymorphism Trp719Arg on the risk of T2DM and T2DM with CHD remains unclear.
  
  
  METHODS
  946 unrelated subjects of Han Chinese origin were recruited, comprising 346 controls, 312 T2DM, and 288 T2DM + CHD patients. Genotyping was performed by high-resolution melting curve analysis using real-time qPCR. The impact of the variant on T2DM/T2DM + CHD and gene-sex interaction were evaluated by stepwise multiple regression analysis.
  
  
  RESULTS
  The frequencies of the Trp719 allele in T2DM and T2DM + CHD patients were similar to the control group, whereas significantly increased 719Arg allele frequencies were observed in male T2DM and T2DM + CHD patients compared with the corresponding control group. Further sex partition analysis revealed that only male 719Arg allele carriers had approximately 3-fold and 5-fold higher risk of T2DM and T2DM + CHD, respectively, than noncarriers. There was also a significant association between carriers and higher TG and lower HDL-C levels.
  
  
  CONCLUSIONS
  The KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism, especially with regard to TG and HDL.
authors: Department of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, China.
authors: Ge
authors: G
authors: Wu
authors: Department of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, China.
authors: Gui-Bin
authors: GB
authors: Li
authors: Department of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, China.
authors: Bin
authors: B
authors: Dai
authors: Department of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, China.
authors: Dong-Qing
authors: DQ
authors: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; C509805:KIF2A protein, human; D014280:Triglycerides; D016547:Kinesins
references: Hum Mol Genet. 2001 Nov 15;10(24):2751-65
references: 11734540
references: PLoS One. 2011;6(12):e28834
references: 22216121
references: Endocr Rev. 2012 Aug;33(4):526-46
references: 22577090
references: Molecules. 2012;17(9):11269-80
references: 23001387
references: Nurs Res Pract. 2014;2014:328954
references: 24587901
references: J Am Coll Cardiol. 2008 Jun 3;51(22):2195; author reply 2195-6
references: 18510970
references: J Am Coll Cardiol. 2008 Jan 29;51(4):435-43
references: 18222353
references: Am J Cardiol. 2010 May 1;105(9):1300-5
references: 20403483
references: Pathobiol Aging Age Relat Dis. 2014 Feb 12;4:null
references: 24563731
references: J Am Coll Cardiol. 2008 Jan 29;51(4):444-8
references: 18222354
references: J Lipid Res. 2006 Sep;47(9):1908-14
references: 16741292
references: J Am Coll Cardiol. 2009 Apr 21;53(16):1471-2
references: 19371834
references: Nature. 2010 Aug 5;466(7307):707-13
references: 20686565
references: Diabetes Metab. 2001 Apr;27(2 Pt 2):261-70
references: 11452220
references: Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):150-9
references: 19229235
references: Eur J Cardiovasc Prev Rehabil. 2010 Aug;17(4):455-61
references: 20215968
references: J Alzheimers Dis. 2013;33(1):111-6
references: 22914592
references: Mol Genet Metab. 2007 Apr;90(4):422-8
references: 17123852
references: J Genet Genomics. 2007 Oct;34(10):877-84
references: 17945166
references: Atherosclerosis. 2012 Feb;220(2):456-62
references: 22192511
references: Nat Rev Drug Discov. 2006 Apr;5(4):295-309
references: 16582875
references: PLoS One. 2010;5(9). pii: e13081. doi: 10.1371/journal.pone.0013081
references: 20927332
references: J Cell Biol. 2014 Feb 3;204(3):395-408
references: 24469637
references: Ter Arkh. 2012;84(9):35-40
references: 23091851
references: Am J Cardiol. 2010 Oct 1;106(7):994-8
references: 20854963
references: Cell. 1985 Aug;42(1):39-50
references: 3926325
references: Genet Med. 2007 Oct;9(10):682-9
references: 18073581
references: Am J Epidemiol. 2007 Jul 1;166(1):28-35
references: 17443022
references: Eur Rev Med Pharmacol Sci. 2013 Oct;17(19):2654-9
references: 24142614
references: Trends Cell Biol. 2005 Sep;15(9):467-76
references: 16084724
references: Mol Cell Biochem. 2009 Oct;330(1-2):31-8
references: 19381781
references: Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):173-9
references: 17975119
references: J Am Coll Cardiol. 2008 Jan 29;51(4):449-55
references: 18222355
references: Kardiol Pol. 2008 Oct;66(10):1042-8; discussion 1049
references: 19006025
references: J Cell Sci. 2002 Nov 15;115(Pt 22):4327-39
references: 12376564
references: Gene. 2013 Jul 1;523(1):20-6
references: 23583468
references: Lancet. 2008 May 24;371(9626):1800-9
references: 18502305