title: Automatic Detection of White Matter Hyperintensities in Healthy Aging and Pathology Using Magnetic Resonance Imaging: A Review.
abstract: White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular disorders. A truly reliable and fully automated method for quantitative assessment of WMH on magnetic resonance imaging (MRI) has not yet been identified. In this paper, we review and compare the large number of automated approaches proposed for segmentation of WMH in the elderly and in patients with vascular risk factors. We conclude that, in order to avoid artifacts and exclude the several sources of bias that may influence the analysis, an optimal method should comprise a careful preprocessing of the images, be based on multimodal, complementary data, take into account spatial information about the lesions and correct for false positives. All these features should not exclude computational leanness and adaptability to available data.
authors: Neuroimaging Unit, Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Germaneto, CZ, Italy.
authors: Maria Eugenia
authors: ME
authors: Caligiuri
authors: Paolo
authors: P
authors: Perrotta
authors: Antonio
authors: A
authors: Augimeri
authors: Federico
authors: F
authors: Rocca
authors: Aldo
authors: A
authors: Quattrone
authors: Andrea
authors: A
authors: Cherubini
mesh_terms: D000375:Aging / Q000473:pathology*; D000465:Algorithms; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D066127:White Matter / Q000473:pathology*
references: AJNR Am J Neuroradiol. 1997 Apr;18(4):699-704
references: 9127033
references: Neuroimage. 2008 Jul 15;41(4):1253-66
references: 18482850
references: J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):197-203
references: 9489530
references: Eur Neurol. 1998;39(2):80-9
references: 9520068
references: IEEE Trans Med Imaging. 1997 Dec;16(6):878-86
references: 9533587
references: Biol Psychiatry. 2008 Aug 15;64(4):273-80
references: 18471801
references: Psychol Bull. 1979 Mar;86(2):420-8
references: 18839484
references: Adv Med Sci. 2008;53(2):182-90
references: 18842559
references: Magn Reson Imaging. 1998 Apr;16(3):311-8
references: 9621972
references: AJNR Am J Neuroradiol. 1999 Jan;20(1):133-7
references: 9974068
references: Neuroimage. 2009 May 1;45(4):1151-61
references: 19344687
references: Neuroimage. 2009 Aug 1;47(1):199-203
references: 19344777
references: Inf Process Med Imaging. 2009;21:239-51
references: 19694267
references: Comput Med Imaging Graph. 2009 Dec;33(8):644-50
references: 19674872
references: Comput Med Imaging Graph. 2010 Jul;34(5):370-6
references: 20116974
references: J Magn Reson Imaging. 2010 Jun;31(6):1311-22
references: 20512882
references: Eur Radiol. 2010 Jul;20(7):1684-91
references: 20157814
references: BMJ. 2010;341:c3666
references: 20660506
references: Neuroimage. 2011 Jan 15;54(2):963-73
references: 20849961
references: Neuroimage. 2011 Jul 15;57(2):416-22
references: 21569857
references: Psychiatry Res. 2011 Aug 30;193(2):101-6
references: 21680159
references: J Alzheimers Dis. 2011;26 Suppl 3:379-88
references: 21971477
references: Magn Reson Imaging. 2012 Feb;30(2):222-9
references: 22071410
references: IEEE Trans Biomed Eng. 2012 Mar;59(3):860-71
references: 22203699
references: Neuroimage. 2012 Feb 15;59(4):3774-83
references: 22119648
references: Neuroimage. 2012 May 1;60(4):2379-88
references: 22387175
references: Magn Reson Imaging. 2012 Jul;30(6):807-23
references: 22578927
references: PLoS One. 2012;7(11):e48953
references: 23152828
references: Med Image Anal. 2013 Jan;17(1):1-18
references: 23084503
references: J Magn Reson Imaging. 2013 Feb;37(2):343-50
references: 23023955
references: J Neurosci Methods. 2013 Feb 15;213(1):138-46
references: 23261771
references: Lancet Neurol. 2013 Aug;12(8):822-38
references: 23867200
references: Magn Reson Imaging. 2013 Sep;31(7):1182-9
references: 23684961
references: J Magn Reson Imaging. 2013 Oct;38(4):774-85
references: 23441036
references: Acta Neuropathol Commun. 2013;1:14
references: 24252608
references: AJNR Am J Neuroradiol. 2013 Dec;34(12):2265-70
references: 23868156
references: Neuroradiology. 2014 Apr;56(4):265-81
references: 24493377
references: IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
references: 11293691
references: J Neuroimaging. 2001 Oct;11(4):412-7
references: 11677882
references: J Magn Reson Imaging. 2001 Dec;14(6):668-76
references: 11747022
references: Neuron. 2002 Jan 31;33(3):341-55
references: 11832223
references: Psychiatry Res. 2002 Aug 20;115(1-2):63-77
references: 12165368
references: Neuroimage. 2002 Nov;17(3):1087-100
references: 12414252
references: Stroke. 2004 Feb;35(2):415-9
references: 14726554
references: Neuroimage. 2004 Mar;21(3):1037-44
references: 15006671
references: Neurology. 2004 May 11;62(9):1533-9
references: 15136677
references: Neuroimage. 2004 Aug;22(4):1492-502
references: 15275906
references: Neurology. 1995 Nov;45(11):2077-84
references: 7501162
references: Brain. 1996 Aug;119 ( Pt 4):1349-55
references: 8813296
references: Acta Neurol Scand. 1996 Jan;93(1):30-4
references: 8825269
references: Magn Reson Imaging. 1996;14(5):495-505
references: 8843362
references: AJNR Am J Neuroradiol. 1999 May;20(5):813-20
references: 10369351
references: Neuroimage. 2005 Nov 15;28(3):607-17
references: 16129626
references: Neurology. 2006 Jan 10;66(1):23-9
references: 16401840
references: Stroke. 2006 Mar;37(3):836-40
references: 16439704
references: AJNR Am J Neuroradiol. 2006 Apr;27(4):875-8
references: 16611781
references: Psychiatry Res. 2006 Dec 1;148(2-3):133-42
references: 17097277
references: Neuroradiology. 2008 Jan;50(1):31-42
references: 17938898
references: Neuroimage. 2008 Feb 1;39(3):987-96
references: 18006334
references: Acad Radiol. 2008 Mar;15(3):300-13
references: 18280928
references: Am J Psychiatry. 2008 Apr;165(4):524-32
references: 18281408
references: Neuroimage. 2008 Jun;41(2):335-45
references: 18394928
references: Stroke. 1997 Aug;28(8):1614-23
references: 9259759