title: Magnetically Targeted Nanocapsules for PAA-Cisplatin-Conjugated Cores in PVA/SPIO Shells via Surfactant-Free Emulsion for Reduced Nephrotoxicity and Enhanced Lung Cancer Therapy.
abstract: Cis-diamminedichloroplatinum (II) (cisplatin, CDDP) is one of the most potent chemotherapy agents, but its side effects toward normal tissues, particularly toxicity in the kidney and nonspecific biodistribution, limit its ability to have significant clinical activity against a variety of solid tumors. A magnetic CDDP-encapsulated nanocapsule (CDDP-PAA-NC) with CDDP-polyacrylic acid (PAA) core in amphiphilic polyvinyl alcohol/superparamagnetic iron oxide nanoparticles shell is synthesized through a double emulsion to provide both high loading efficiency and controlled drug release. The CDDP-PAA-NCs significantly increase the blood circulation time of CDDP in vivo, with nearly 100-fold higher concentration, and drastically reduce side effects, including nephrotoxicity and hepatotoxicity, compared with the delivery of free CDDP. Furthermore, with a magnetic targeting effect, the CDDP-PAA-NCs show ninefold higher level accumulation in tumor tissue than the free CDDP treatment when administered at the equivalent dose, and mice treated with the CDDP-PAA-NCs display approximately 3.5-fold lower tumor volume than those of the control group on day 24. This result demonstrates that the magnetic CDDP-PAA-NCs, which are synthesized using a facile emulsion process, can significantly reduce toxicity and exhibit anticancer activity in A549-tumor bearing mice with negligible side effects.
authors: Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu City, 30010, Taiwan, R.O.C.
authors: Chih-Sheng
authors: CS
authors: Chiang
authors: Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu City, 30010, Taiwan, R.O.C.
authors: Yi-Hsuan
authors: YH
authors: Tseng
authors: BioFirst Corporation, 5F, #248, Sec. 1, Neihu Rd., Neihu District, Taipei City, 114, Taiwan, R.O.C.
authors: Bang-Jie
authors: BJ
authors: Liao
authors: Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu City, 30010, Taiwan, R.O.C.
authors: San Yuan
authors: SY
authors: Chen
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D004655:Emulsions / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008280:Magnetics / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000008:administration & dosage / Q000737:chemistry*; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D053769:Nanocapsules; D013501:Surface-Active Agents; C006903:carbopol 940; D011142:Polyvinyl Alcohol; D002945:Cisplatin
keywords: cisplatin; magnetic targeting; superparamagnetic nanoparticles; tumor selectivity