title: Genetic studies of schizophrenia: an update.
abstract: Schizophrenia (SCZ) is a complex and heterogeneous mental disorder that affects about 1% of global population. In recent years, considerable progress has been made in genetic studies of SCZ. A number of common variants with small effects and rare variants with relatively larger effects have been identified. These variants include risk loci identified by genome-wide association studies, rare copy-number variants identified by comparative genomic analyses, and de novo mutations identified by high-throughput DNA sequencing. Collectively, they contribute to the heterogeneity of the disease. In this review, we update recent discoveries in the field of SCZ genetics, and outline the perspectives of future directions.
authors: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA, jchen@vcu.edu.
authors: Jingchun
authors: J
authors: Chen
authors: Fei
authors: F
authors: Cao
authors: Lanfen
authors: L
authors: Liu
authors: Lina
authors: L
authors: Wang
authors: Xiangning
authors: X
authors: Chen
mesh_terms: D056915:DNA Copy Number Variations; D055106:Genome-Wide Association Study; D006801:Humans; D009154:Mutation; D012559:Schizophrenia / Q000235:genetics*
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