title: [Massive granuloma formation after long-term use of dermal fillers].
abstract: BACKGROUND
  Since dermal fillers were introduced in 1981, millions of patients have undergone wrinkle treatment with dermal fillers. Except for autologous fat, all fillers can act as potential foreign bodies, which have the potential ability to induce an immune reaction. Persisting material may induce activation of the immune system and finally granuloma formation. Frequency, histology, and clinical presentation of such foreign body reactions may vary depending on the filler used.
  
  
  METHODS
  This case describes a patient who received innumerable filler injections over the last two decades presenting with massive facial granulomas.
authors: Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, 02129, Charlestown, MA, USA, EROIDER@cbrc2.mgh.harvard.edu.
authors: E M
authors: EM
authors: Roider
authors: G
authors: G
authors: Gauglitz
authors: M J
authors: MJ
authors: Flaig
authors: T
authors: T
authors: Ruzicka
authors: J
authors: J
authors: Schauber
mesh_terms: D000368:Aged; D000067548:Dermal Fillers / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D015745:Granuloma, Foreign-Body / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D008137:Longitudinal Studies
chemical_list: D000067548:Dermal Fillers; D006820:Hyaluronic Acid
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