title: Intratumoral hemorrhage in a patient with cerebellar hemangioblastoma: a case report and review.
abstract: Spontaneous hemorrhage is rarely associated with hemangioblastomas. Intratumoral hemorrhage occurring in cerebellar hemangioblastomas is more rare. A 25-year-old man was admitted to our hospital with headache. We found a round cystic lesion with solid part in the right cerebellum. The lesion was resected. The final pathological diagnosis was hemangioblastomas. The radiological features of this case were similar to normal hemangioblastomas, whereas our histological examination showed the occurrence of the intratumoral hemorrhage. If the hemangioblastoma ruptures in our case, the outcome of the patient will be worse. It is difficult to identify the intratumoral hemorrhage of hemangioblastomas and quite dangerous if it is diagnosed late. Diagnosing an intratumoral hemorrhage of hemangioblastomas still needs a further discussion. Genetic screening may help us make an early diagnosis. Furthermore, the mechanism about intratumoral hemorrhage of hemangioblastomas remains unknown. The mutation of D6Mit135 gene on chromosome 6 may be responsible for the vascular dilation and hemorrhage induction in the hemangioblastomas. Tumor size, upregulation of vascular endothelial growth factor, spinalradicular location, and solid type are also factors relating to the hemorrhage of hemangioblastomas. The purpose of reporting our case is 2-fold: to remind clinicians to consider the possibility of internal hemorrhaging while diagnosing this disease, and provide a starting point to discuss mechanisms regarding the intratumoral hemorrhage of hemangioblastomas.
authors: From the Department of Neurosurgery (ZW, JH, LX, SC), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; and Department of Physiology and Pharmacology (JM), Loma Linda University, Loma Linda, CA, USA.
authors: Zhen
authors: Z
authors: Wang
authors: Jun
authors: J
authors: Hu
authors: Liang
authors: L
authors: Xu
authors: Jay
authors: J
authors: Malaguit
authors: Sheng
authors: S
authors: Chen
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000601:surgery; D006261:Headache / Q000209:etiology; D018325:Hemangioblastoma / Q000473:pathology* / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
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