title: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.
abstract: The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.
authors: NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, 117456, Singapore.
authors: Xuanyao
authors: X
authors: Liu
authors: Yushimah
authors: Y
authors: Yunus
authors: Dongsheng
authors: D
authors: Lu
authors: Farhang
authors: F
authors: Aghakhanian
authors: Woei-Yuh
authors: WY
authors: Saw
authors: Lian
authors: L
authors: Deng
authors: Mohammad
authors: M
authors: Ali
authors: Xu
authors: X
authors: Wang
authors: Fadzilah Mohd
authors: FM
authors: Nor
authors: Fadzilah
authors: F
authors: Ghazali
authors: Thuhairah Abdul
authors: TA
authors: Rahman
authors: Shahrul Azlin
authors: SA
authors: Shaari
authors: Mohd Zaki
authors: MZ
authors: Salleh
authors: Maude E
authors: ME
authors: Phipps
authors: Rick Twee-Hee
authors: RT
authors: Ong
authors: Shuhua
authors: S
authors: Xu
authors: Yik-Ying
authors: YY
authors: Teo
authors: Boon-Peng
authors: BP
authors: Hoh
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics; D015820:Cadherins / Q000235:genetics; D060467:Disease Resistance / Q000235:genetics*; D055106:Genome-Wide Association Study; D051547:Heme Oxygenase-1 / Q000235:genetics; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics; D008288:Malaria / Q000235:genetics*; D008296:Malaysia / Q000208:ethnology; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics*; D012641:Selection, Genetic; D059467:Transcriptome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D019014:fas Receptor / Q000235:genetics
chemical_list: D015820:Cadherins; C491901:FAS protein, human; C099972:H-cadherin; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
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