title: Fss1 is involved in the regulation of an ENA5 homologue for sodium and lithium tolerance in Fusarium graminearum.
abstract: Sodium is an abundant cation required for protein function and maintenance of cellular osmotic homeostasis. High concentrations of sodium are toxic, and fungi have evolved efficient sodium efflux systems. In this study, we characterized a novel sodium tolerance mechanism in the plant pathogen Fusarium graminearum. Fusarium graminearum sodium sensitive 1 (Fss1) is a nuclear transcription factor with a Zn(II)2 Cys6 fungal-type DNA-binding domain required for sodium tolerance. RNA-seq and genetic studies revealed that a P-type ATPase pump, exitus natru (Latin: exit sodium) 1 (FgEna5), mediates the phenotypic defects of FSS1 mutants. A homologue of PACC (PAC1) was required for FgEna5-dependent sodium and lithium tolerance independent of Fss1. The results of this study revealed that F. graminearum has a distinct and novel pathway for sodium tolerance not present in other model fungi.
authors: Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921, Korea.|Center for Fungal Pathogenesis, Seoul National University, Seoul, 151-921, Korea.
authors: Hokyoung
authors: H
authors: Son
authors: Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921, Korea.|Center for Fungal Pathogenesis, Seoul National University, Seoul, 151-921, Korea.
authors: Ae Ran
authors: AR
authors: Park
authors: Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921, Korea.|Center for Fungal Pathogenesis, Seoul National University, Seoul, 151-921, Korea.
authors: Jae Yun
authors: JY
authors: Lim
authors: Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921, Korea.|Center for Fungal Pathogenesis, Seoul National University, Seoul, 151-921, Korea.
authors: Yin-Won
authors: YW
authors: Lee
mesh_terms: D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D005670:Fusarium / Q000235:genetics / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D014157:Transcription Factors; D008094:Lithium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase