title: Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?
abstract: Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28±2.37 years; BMI: 35.65±4.64 kg/m2) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls.
authors: Post-Graduate Program of Interdisciplinary Health Sciences, Universidade Federal de São Paulo, Santos, SP, Brazil. Electronic address: carvalhoferreira.jp@gmail.com.
authors: Joana Pereira
authors: JP
authors: de Carvalho-Ferreira
authors: Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Deborah Cristina Landi
authors: DC
authors: Masquio
authors: Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Raquel Munhoz
authors: RM
authors: da Silveira Campos
authors: Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Bárbara
authors: B
authors: Dal Molin Netto
authors: Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Flavia Campos
authors: FC
authors: Corgosinho
authors: Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Priscila L
authors: PL
authors: Sanches
authors: Weight Science, São Paulo, SP, Brazil.
authors: Lian
authors: L
authors: Tock
authors: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Sergio
authors: S
authors: Tufik
authors: Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Marco Túlio
authors: MT
authors: de Mello
authors: Institute of Psychological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.
authors: Graham
authors: G
authors: Finlayson
authors: Post-Graduate Program of Interdisciplinary Health Sciences, Universidade Federal de São Paulo, Santos, SP, Brazil; Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: ana.damaso@unifesp.br.
authors: Ana R
authors: AR
authors: Dâmaso
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D003863:Depression / Q000097:blood / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D015870:Gene Expression; D006801:Humans; D020738:Leptin / Q000097:blood / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D012737:Sex Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D061217:Weight Reduction Programs / Q000379:methods*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin; D014280:Triglycerides
keywords: Adolescents; Depression; Inflammation; Leptin; Leptin resistance; Obesity