title: Alkynylation of heterocyclic compounds using hypervalent iodine reagent.
abstract: The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.
authors: Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 43, Praha 2, Czech Republic. jxvesely@natur.cuni.cz.
authors: M
authors: M
authors: Kamlar
authors: I
authors: I
authors: Císařová
authors: J
authors: J
authors: Veselý
mesh_terms: D000114:Acetylene / Q000737:chemistry; D000477:Alkylating Agents / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D007211:Indoles / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D000078183:Oxindoles; D012236:Rhodanine / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013696:Temperature
chemical_list: D000477:Alkylating Agents; D001688:Biological Products; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007211:Indoles; D007454:Iodides; D007783:Lactones; D009930:Organic Chemicals; D000078183:Oxindoles; D012997:Solvents; C022960:2-oxindole; D002244:Carbon; D012236:Rhodanine; D007455:Iodine; D000114:Acetylene