title: Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect.
abstract: Low functioning MAOA genotypes have been reliably linked to increased reactive aggression, yet the psychological mechanisms of this effect remain largely unknown. The low functioning MAOA genotype's established link to diminished inhibition and greater reactivity to conditions of negative affect suggest that negative urgency, the tendency to act impulsively in the context of negative affect, may fill this mediating role. Such MAOA carriers may have higher negative urgency, which may in turn predict greater aggressive responses to provocation. To test these hypotheses, 277 female and male participants were genotyped for an MAOA SNP yet to be linked to aggression (rs1465108), and then reported their negative urgency and past aggressive behavior. We replicated the effect of the low functioning MAOA genotype on heightened aggression, which was mediated by greater negative urgency. These results suggest that disrupted serotonergic systems predispose individuals towards aggressive behavior by increasing impulsive reactivity to negative affect.
authors: Department of Psychology, University of Kentucky, 0003 Kastle Hall, Lexington, KY 40506, USA. Electronic address: davidchester@uky.edu.
authors: David S
authors: DS
authors: Chester
authors: Department of Psychology, University of Kentucky, 0003 Kastle Hall, Lexington, KY 40506, USA.
authors: C Nathan
authors: CN
authors: DeWall
authors: Department of Psychology, University of Kentucky, 0003 Kastle Hall, Lexington, KY 40506, USA.
authors: Karen J
authors: KJ
authors: Derefinko
authors: Department of Physiology, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
authors: Steven
authors: S
authors: Estus
authors: Department of Psychology, University of Kentucky, 0003 Kastle Hall, Lexington, KY 40506, USA.
authors: Jessica R
authors: JR
authors: Peters
authors: Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA.
authors: Donald R
authors: DR
authors: Lynam
authors: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Department of Behavioral Science, University of Kentucky, Lexington, KY, USA.
authors: Yang
authors: Y
authors: Jiang
mesh_terms: D000293:Adolescent; D000374:Aggression / Q000502:physiology; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D008960:Models, Psychological; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011581:Psychological Tests; D055815:Young Adult
chemical_list: D008995:Monoamine Oxidase
keywords: Aggression; Genetics; Impulsivity; MAOA; Negative urgency; UPPS model
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