title: Effect of propranolol on capsular reaction around silicone implants in guinea pigs.
abstract: OBJECTIVE
  To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.
  
  
  METHODS
  Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).
  
  
  RESULTS
  Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.
  
  
  CONCLUSIONS
  Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
authors: Christus Universitary Center, Fortaleza, CE, Brazil.
authors: Charles Jean Gomes de
authors: CJ
authors: Mesquita
authors: Department of Surgery, UFC, Fortaleza, CE, Brazil.
authors: Sérgio Botelho
authors: SB
authors: Guimarães
authors: UFC, Fortaleza, CE, Brazil.
authors: José Alberto Dias
authors: JA
authors: Leite Filho
authors: UNICHRISTUS, Fortaleza, CE, Brazil.
authors: Felipe Silva
authors: FS
authors: Maciel
authors: UFC, Fortaleza, CE, Brazil.
authors: José Lima de Carvalho
authors: JL
authors: Rocha
authors: UFC, Fortaleza, CE, Brazil.
authors: José Alberto Dias
authors: JA
authors: Leite
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D018427:Breast Implants / Q000009:adverse effects; D024042:Collagen Type I / Q000032:analysis / Q000187:drug effects; D024061:Collagen Type III / Q000032:analysis / Q000187:drug effects; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D057910:Implant Capsular Contracture / Q000473:pathology / Q000517:prevention & control*; D020007:Implants, Experimental / Q000009:adverse effects; D008297:Male; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D015203:Reproducibility of Results; D020034:Silicone Gels / Q000009:adverse effects*; D040521:Subcutaneous Tissue / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D024042:Collagen Type I; D024061:Collagen Type III; D020034:Silicone Gels; D011433:Propranolol