title: ATM, THMS, and RRM1 protein expression in nasopharyngeal carcinomas treated with curative intent.
abstract: In advanced nasopharyngeal carcinoma (NPC), biomarkers may help predict survival.
  
  
  
  Tumoral expression of ataxia-telangiectasia mutated (ATM), thymidylate synthetase (THMS), and ribonucleotide reductase subunit M1 (RRM1), was correlated with survival in patients with nonmetastatic NPC using quantitative fluorescence immunohistochemistry with automated quantitative digital image analysis.
  
  
  
  Of the 146 patients included, 58 patients (40%) received concurrent chemoradiation therapy; the remainder was treated with radiation. Overall survival (OS) at 5 years was 71% (95% confidence interval [CI], 62% to 78%); disease-free survival (DFS) was 48% (95% CI, 39% to 57%). OS worsened for increasing values of ATM (hazard ratio [HR], 2.83; 95% CI, 1.01-7.94; p = .049) for values greater than the 75th percentile compared to less than the 25th percentile, but improved for tumors with higher THMS levels (HR, 0.44; 95% CI, 0.20-0.94; p = .033) for values greater than the 25th percentile compared to less than or equal to the 25th percentile. RRM1 was not associated with OS (p = .748). No biomarkers were associated with DFS.
  
  
  
  In our cohort, relative overexpression of ATM and low THMS levels were associated with worse OS. © 2015 Wiley Periodicals, Inc. Head Neck 38: E384-E391, 2016.
authors: Department of Medical Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors: Jenny Jaeeun
authors: JJ
authors: Ko
authors: Functional Tissue Imaging Unit, Translational Research Laboratory, University of Calgary, Calgary, Alberta, Canada.
authors: Alexander C
authors: AC
authors: Klimowicz
authors: Department of Allergy and Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors: Amanda
authors: A
authors: Jagdis
authors: Department of Radiation Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors: Tien
authors: T
authors: Phan
authors: Department of Medical Oncology, British Columbia Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Janessa
authors: J
authors: Laskin
authors: Department of Radiation Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors: Harold Y
authors: HY
authors: Lau
authors: Department of Biostatistics, Public Health Innovation & Decision Support Population and Public Health, Alberta Health Services, Alberta, Canada.
authors: Jodi E
authors: JE
authors: Siever
authors: Functional Tissue Imaging Unit, Translational Research Laboratory, University of Calgary, Calgary, Alberta, Canada.
authors: Stephanie K
authors: SK
authors: Petrillo
authors: Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors: Thomas A
authors: TA
authors: Thomson
authors: Department of Biostatistics, Research Facilitation, Alberta Health Services, Alberta, Canada.
authors: M Sarah
authors: MS
authors: Rose
authors: Department of Medical Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors: Gwyn
authors: G
authors: Bebb
authors: Department of Anatomic Pathology, Esoteric Laboratory Services, H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Anthony M
authors: AM
authors: Magliocco
authors: Department of Medical Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors: Desirée
authors: D
authors: Hao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D012262:Ribonucleoside Diphosphate Reductase; D015996:Survival Rate; D013940:Thymidylate Synthase / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D025521:Tumor Suppressor Proteins; C475286:RRM1 protein, human; D012262:Ribonucleoside Diphosphate Reductase; D013940:Thymidylate Synthase; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins
keywords: ataxia-telangiectasia mutated (ATM); nasopharyngeal carcinoma; ribonucleotide reductase subunit M1 (RRM1); thymidylate synthetase (THMS)