title: Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study was to determine the effect of obesity, gestational diabetes mellitus (GDM) on circulating chemerin concentrations and chemerin gene expression of adipotissue in pregnancy women.
  
  
  METHODS
  Totally 42 normal glucose tolerant (NGT) women and 48 women with GDM were included in this study. Their clinical features and biochemical parameters were analyzed. The NGT and GDM women were subgrouped by prepregnancy BMI as normal-weight group, overweight group, and obese group, respectively. Serum chemerin and tumor necrosis factor α (TNF-α) of these individuals were determined by ELISA methods, and subcutaneous adipose tissues' mRNA expressions of chemerin and CMKLR1 (encoding the receptor of chemerin) were analyzed by real-time PCR.
  
  
  RESULTS
  Serum chemerin in obese-NGT group and normal-weight-GDM group was significantly higher than that of normal-weight-NGT group. Chemerin and CMKLR1 mRNA expression of subcutaneous adipose tissue was lower in the obese-NGT group than normal-weight-NGT group. There was no significant difference of CMKLR1 mRNA expression between normal-weight-NGT and normal-weight-GDM group. Serum chemerin significantly and positively correlated with triglycerides (TG) and homeostasis model assessment of insulin resistance (HOMA-IR) assessed both by uni- and multivariate.
  
  
  CONCLUSIONS
  Gestational obesity, GDM may contribute to the elevating serum chemerin. Serum chemerin in pregnancy was associated with insulin resistance and triglycerides. Chemerin gene may play a role both in obese and GDM patients. CMKLR1 might exert its action only in obese individuals, not in GDM patients before delivery.
authors: The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
authors: Xue-Mei
authors: XM
authors: Li
authors: Department of obstetrics, Tianjin Central gynaecology and obstetrics Hospital, Tianjin, China.
authors: Hui
authors: H
authors: Ji
authors: The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
authors: Chun-Jun
authors: CJ
authors: Li
authors: The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
authors: Peng-Hua
authors: PH
authors: Wang
authors: The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. Electronic address: yupei@tijmu.edu.cn.
authors: Pei
authors: P
authors: Yu
authors: The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. Electronic address: yudemintij@126.com.
authors: De-Min
authors: DM
authors: Yu
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism; D015992:Body Mass Index; D018925:Chemokines / Q000097:blood / Q000235:genetics*; D016640:Diabetes, Gestational / Q000097:blood / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D012333:RNA, Messenger; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha
keywords: Chemerin; Gestational diabetes mellitus; Obesity