title: Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users.
abstract: The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.
authors: Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.
authors: Wenfu
authors: W
authors: Hu
authors: Department of Neurosurgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China ; Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
authors: Xiangming
authors: X
authors: Fu
authors: Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
authors: Ruobing
authors: R
authors: Qian
authors: Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
authors: Xiangpin
authors: X
authors: Wei
authors: Department of MRI, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui Province, China.
authors: Xuebing
authors: X
authors: Ji
authors: Department of Neurosurgery, Anhui Provincial Institute of Stereotactic Neurosurgery, Hefei 230001, Anhui Province, China.
authors: Chaoshi
authors: C
authors: Niu
keywords: default mode network; functional MRI; heroin user; independent component analysis; neural regeneration; resting state
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