title: Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats.
abstract: The present study evaluated the antidiabetic effect of osajin and pomiferin from the osajin orange in normal and streptozotocin-induced diabetic rats. Pomiferin in the streptozotocin-induced diabetic effects showed significant hypoglycemic activity for 14 days significantly decreased the serum glucose, triglyceride while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05; at doses of 100 and 300 mg/kg for 14 days). Pomiferin showed potential in anti-diabetic effects compared to osajin. It also has no effects on C-peptide (ECLIA). Further structure-activity relationships of aromatic position 3 on ring B from osajin and pomiferin will be reported in due course.
authors: Hyung-In
authors: HI
authors: Moon
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007529:Isoflavones / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013311:Streptozocin
chemical_list: D001578:Benzopyrans; D007004:Hypoglycemic Agents; D007529:Isoflavones; D013311:Streptozocin; C474837:pomiferin; C485800:osajin