title: Progression of renal damage in glycogen storage disease type I is associated to hyperlipidemia: a multicenter prospective Italian study.
abstract: Angiotensin converting enzyme (ACE)-inhibitors decrease glomerular hyperfiltration but not microalbuminuria and proteinuria in glycogen storage disease type I. In the current study, we demonstrated that severe hyperlipidemia is associated with ACE-inhibitor ineffectiveness. We underline the importance of adequate metabolic control in glycogen storage disease type I. A combination therapy with ACE-inhibitors and lipid lowering drugs might be considered.
authors: Welfare Department of Pediatrics, Azienda Ospedaliera Universitaria Federico II, Naples, Italy. Electronic address: daniela.melis@unina.it.
authors: Daniela
authors: D
authors: Melis
authors: Department of Medical Sciences Translational, Sezione di Pediatria, Università Federico II, Naples, Italy.
authors: Mariarosaria
authors: M
authors: Cozzolino
authors: Department of Medical Sciences Translational, Sezione di Pediatria, Università Federico II, Naples, Italy.
authors: Giorgia
authors: G
authors: Minopoli
authors: Department of Medical Sciences Translational, Sezione di Pediatria, Università Federico II, Naples, Italy.
authors: Francesca
authors: F
authors: Balivo
authors: Department of Pediatrics, Ospedale S. Gerardo, Monza, Italy.
authors: Rossella
authors: R
authors: Parini
authors: Department of Pediatrics, Ospedale S. Gerardo, Monza, Italy.
authors: Miriam
authors: M
authors: Rigoldi
authors: Department of Pediatrics, Ospedale S. Paolo, Milan, Italy.
authors: Sabrina
authors: S
authors: Paci
authors: Division of Medical Pathology, Ospedale Bambino Gesù, Rome, Italy.
authors: Carlo
authors: C
authors: Dionisi-Vici
authors: Division of Medical Pathology, Università degli studi di Padova, Padova, Italy.
authors: Alberto
authors: A
authors: Burlina
authors: Department of Medical Sciences Translational, Sezione di Pediatria, Università Federico II, Naples, Italy.
authors: Generoso
authors: G
authors: Andria
authors: Department of Medical Sciences Translational, Sezione di Pediatria, Università Federico II, Naples, Italy.
authors: Giancarlo
authors: G
authors: Parenti
mesh_terms: D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002648:Child; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005953:Glycogen Storage Disease Type I / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids