title: Physico-chemical properties and hypoglycaemic activity of fermented milks prepared with Anemarrhena asphodeloides water extracts.
abstract: BACKGROUND
  In this research, water extract solutions of Anemarrhena asphodeloides (AA) rhizomes were added to reconstituted milk at 5%, 10% and 15% (v/v) to prepare AA fermented milk (AAFM5, AAFM10 and AAFM15). The AAFM10 was selected for investigation of hypoglycaemic activity.
  
  
  RESULTS
  Compared with the control fermented milk, titratable acidity values and water-holding capacities of AA fermented milk were increased to different extents, but syneresis values were reduced. The viable counts of Streptococcus thermophilus, Lactobacillus bulgaricus and Bifidobacterium adolescentis were significantly increased, respectively. The blood sugar level of streptozotocin diabetic mice taking AAFM10 was reduced by 14.4%, and the food intake was decreased. The contents of malondialdehyde, blood urea nitrogen, serum creatinine, triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced by different degrees, and insulin and total superoxide dismutase were significantly increased.
  
  
  CONCLUSIONS
  AAFM10 had a significant hypoglycaemic effect and improvement in the complications (such as kidney disease and hyperlipemia) in the mouse model of diabetes.
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Rong
authors: R
authors: Zhang
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Liu
authors: L
authors: Yang
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Jing
authors: J
authors: Ji
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Bei-bei
authors: BB
authors: Li
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Lan
authors: L
authors: Li
authors: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, 230009, Anhui, China.
authors: Ming
authors: M
authors: Ye
mesh_terms: D031403:Anemarrhena / Q000737:chemistry*; D000818:Animals; D001644:Bifidobacterium; D001786:Blood Glucose / Q000187:drug effects*; D043302:Cultured Milk Products / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007328:Insulin / Q000378:metabolism; D007778:Lactobacillus; D008315:Malondialdehyde; D051379:Mice; D053147:Plant Exudates / Q000737:chemistry*; D048249:Streptococcus thermophilus; D013482:Superoxide Dismutase; D014867:Water
chemical_list: D001786:Blood Glucose; D007328:Insulin; D053147:Plant Exudates; D014867:Water; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Anemarrhena asphodeloides fermented milk; diabetic complications; hypoglycaemic activity; lactic acid bacteria; physico-chemical properties