title: [Cross allergy between penicillins and other beta lactam antibiotics--the risk is much less than previously thought].
abstract: Severe IgE-mediated allergic reactions to penicillins are rare but might be fatal. Because some studies demonstrated a high risk of cross-sensitivity to cephalosporins and carbapenems it has been recommended to avoid these antibiotics in patients with suspected hypersensitivity to penicillins. However, recent studies and analyses conclude that the risk of cross-reactivity was overestimated in the earlier studies and that it is in fact very low for parenteral cephalosporins and perhaps even negligible for carbapenems. The new knowledge has implications for the choice of therapy for bacterial infections in patients with a history of penicillin hypersensitivity, because alternative antibiotic regimens are often inferior to beta-lactam antibiotics. The aim of the present review is to present existing knowledge on cross-sensitivity between beta-lactams, as well as to discuss the management of patients with suspected allergic reactions to these antibiotics.
authors: Akademiska sjukhuset Uppsala - Infektionskliniken Uppsala, Sweden Akademiska sjukhuset Uppsala - Infektionskliniken Uppsala, Sweden.
authors: Thomas
authors: T
authors: Tängden
authors: Akademiska sjuhuset - Infektionskliniken Uppsala, Sweden Akademiska sjuhuset - Infektionskliniken Uppsala, Sweden.
authors: Mia
authors: M
authors: Furebring
authors: Akademiska sjuhuset - Infektionskliniken Uppsala, Sweden Akademiska sjuhuset - Infektionskliniken Uppsala, Sweden.
authors: Elisabeth
authors: E
authors: Löwdin
authors: Skånes universitetssjukhus - Lung- och allergiklniken Lund, Sweden Skånes universitetssjukhus - Lung- och allergiklniken Lund, Sweden.
authors: Sonja
authors: S
authors: Werner
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D010406:Penicillins / Q000009:adverse effects* / Q000276:immunology; D012307:Risk Factors; D047090:beta-Lactams / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams