title: Antibodies against phosphorylcholine are not altered in plasma of patients with Alzheimer's disease.
abstract: BACKGROUND
  Phosphorylcholine is one of the major epitopes of oxidised low density lipoprotein. Low levels of IgM antibodies against phosphorylcholine (anti-PC) are associated with development of myocardial infarction and stroke. It has been shown that patients with Alzheimer's disease and other dementias have significantly lower serum anti-PC levels compared to controls, suggesting that low levels of atheroprotective anti-PC may play a role in AD and dementia.
  
  
  METHODS
  We quantified levels of anti-PC levels using an ELISA in plasma from 176 controls, 125 patients with Alzheimer's disease, 19 patients with vascular dementia and 63 patients with other dementias.
  
  
  RESULTS
  We observed similar plasma anti-PC levels in controls, patients with Alzheimer's disease, and other dementias.
  
  
  CONCLUSIONS
  Our data suggests that anti-PC is not useful as a biomarker for Alzheimer's disease.
authors: Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Edina.Silajdzic@med.lu.se.
authors: Edina
authors: E
authors: Silajdžić
authors: Brain Disease Biomarker Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Maria.Bjorkqvist@med.lu.se.
authors: Maria
authors: M
authors: Björkqvist
authors: Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. Oskar.Hansson@med.lu.se.|Memory Clinic, Skåne University Hospital, Malmö, Sweden. Oskar.Hansson@med.lu.se.
authors: Oskar
authors: O
authors: Hansson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003704:Dementia / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine / Q000276:immunology*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D010767:Phosphorylcholine
references: J Autoimmun. 2010 Mar;34(2):73-9
references: 19726160
references: Nat Rev Neurol. 2010 Mar;6(3):131-44
references: 20157306
references: Stroke. 2010 Apr;41(4):607-12
references: 20150554
references: J Alzheimers Dis. 2010;21(2):577-84
references: 20571218
references: Biofactors. 2012 Mar-Apr;38(2):78-83
references: 22422426
references: J Neurol Sci. 2012 Nov 15;322(1-2):141-7
references: 22884479
references: J Neural Transm Suppl. 2000;59:23-30
references: 10961414
references: BMJ. 2001 Jun 16;322(7300):1447-51
references: 11408299
references: Am J Epidemiol. 2001 Oct 1;154(7):635-41
references: 11581097
references: Arch Neurol. 2001 Nov;58(11):1803-9
references: 11708987
references: Nat Med. 2002 Nov;8(11):1218-26
references: 12411948
references: J Clin Invest. 1995 Nov;96(5):2322-30
references: 7593619
references: Neurology. 1993 Feb;43(2):250-60
references: 8094895
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Lancet. 1996 Apr 27;347(9009):1141-5
references: 8609748
references: Lancet. 1997 Jan 18;349(9046):151-4
references: 9111537
references: Neurology. 1999 Sep 22;53(5):902-5
references: 10496243
references: J Immunol Methods. 2004 Oct;293(1-2):1-11
references: 15541272
references: Neurology. 2005 Aug 23;65(4):545-51
references: 16116114
references: Ann Neurol. 2006 Dec;60(6):677-87
references: 17192928
references: Neurology. 2007 Nov 6;69(19):1850-8
references: 17984453
references: Lancet Neurol. 2008 Feb;7(2):184-90
references: 18207116
references: Neurology. 2009 Jan 27;72(4):368-74
references: 19171835
references: Atherosclerosis. 2009 Apr;203(2):528-32
references: 18809177
references: Eur J Cardiovasc Prev Rehabil. 2009 Jun;16(3):382-6
references: 19369878
references: Clin Immunol. 2010 Jan;134(1):47-54
references: 19748321