title: Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals: a pilot study.
abstract: OBJECTIVE
  The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals.
  
  
  METHODS
  Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables.
  
  
  RESULTS
  A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7 kg/m (4.8 kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4 kg/m (5.6 kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009).
  
  
  CONCLUSIONS
  Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results.
authors: Departments of aInfectious Diseases, Ultrasound Unit bDiagnostic Imaging, Fondazione IRCCS Policlinico San Matteo, University of Pavia cClinical Epidemiology and Biometric Unit dDepartment of Internal Medicine, Fondazione IRCCS Policlinico San Matteo eDepartment of Applied Health Sciences, 'Santa Margherita' Rehabilitation Institute, University of Pavia, Pavia, Italy.
authors: Giovanna
authors: G
authors: Ferraioli
authors: Carmine
authors: C
authors: Tinelli
authors: Raffaella
authors: R
authors: Lissandrin
authors: Mabel
authors: M
authors: Zicchetti
authors: Milena
authors: M
authors: Faliva
authors: Simone
authors: S
authors: Perna
authors: Guido
authors: G
authors: Perani
authors: Francesco
authors: F
authors: Alessandrino
authors: Fabrizio
authors: F
authors: Calliada
authors: Mariangela
authors: M
authors: Rondanelli
authors: Carlo
authors: C
authors: Filice
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D054459:Elasticity Imaging Techniques / Q000379:methods; D005234:Fatty Liver / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000503:physiopathology; D010865:Pilot Projects; D011446:Prospective Studies; D055105:Waist Circumference