title: Volume-dependent hemodynamic effects of blood collection in canine donors - evaluation of 13% and 15% of total blood volume depletion.
abstract: BACKGROUND
  There is no consensus regarding the blood volume that could be safely donated by dogs, ranging from 11 to 25% of its total blood volume (TBV). No previous studies evaluated sedated donors.
  
  
  OBJECTIVE
  To evaluate the hemodynamic effects of blood collection from sedated and non-sedated dogs and to understand if such effects were volume-dependent.
  
  
  METHODS
  Fifty three donations of 13% of TBV and 20 donations of 15% TBV were performed in dogs sedated with diazepam and ketamine. Additionally, a total of 30 collections of 13% TBV and 20 collections of 15% TBV were performed in non-sedated dogs. Non-invasive arterial blood pressures and pulse rates were registered before and 15 min after donation.
  
  
  RESULTS
  Post-donation pulse rates increased significantly in both sedated groups, with higher differences in the 15% TBV collections. Systolic arterial pressures decreased significantly in these groups, while diastolic pressures increased significantly in 13% TBV donations. Non-sedated groups revealed a slight, but significant, SBP decrease. No clinical signs related to donations were registered.
  
  
  CONCLUSIONS
  These results suggest that the collection of 15% TBV in sedated donors induces hemodynamic variations that may compromise the harmlessness of the procedure, while it seems to be a safe procedure in non-sedated dogs.
authors: Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
authors: Rui R F
authors: RR
authors: Ferreira
authors: Departamento de Medicina e Cirurgia, Faculdade de Veterinária, Universidade Autónoma de Barcelona, Barcelona, Spain.
authors: Rafael R
authors: RR
authors: Gopegui
authors: Unidade Multidisciplinar de Investigação em Biomedicina, Porto, Portugal.
authors: Augusto J F
authors: AJ
authors: De Matos
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001782:Blood Donors; D001794:Blood Pressure / Q000502:physiology*; D001800:Blood Specimen Collection / Q000009:adverse effects / Q000662:veterinary*; D001810:Blood Volume / Q000502:physiology*; D004285:Dogs; D006993:Hypnotics and Sedatives
chemical_list: D006993:Hypnotics and Sedatives