title: Effects of curcumin on antioxidation in diabetic rats.
abstract: To investigate the effects of curcumin on antioxidation and its mechanism in diabetic rat model.After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 200,100,50mg•kg-1, administered once a day, continuously 30 days. In 30th day, determine blood glucose (BG) value, after the last injection, determine the serum superoxide dismutase (SOD), malondialdehyde (MDA), glycosylated serum protein (GSP) and free fatty acid (FFA) levels. Compared with the model group rats, In the 10th, 30th administrate, each dose of curcumin group rats' BG, MDA, GSP, FFA levels were significantly reduced, SOD levels was increased significantly.curcumin can significantly improve the antioxidant capacity of diabetic model, improve the metabolic disorder.
authors: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, china.
authors: Mingsan
authors: M
authors: Miao
authors: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, china.
authors: Lin
authors: L
authors: Guo
authors: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, china.
authors: Shuo
authors: S
authors: Tian
authors: Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, china.
authors: Tan
authors: T
authors: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D003474:Curcumin / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006023:Glycoproteins / Q000032:analysis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D000093422:Glycated Serum Proteins
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D006023:Glycoproteins; D013311:Streptozocin; D003474:Curcumin; D000093422:Glycated Serum Proteins