title: The association of ADORA2A and ADORA2B polymorphisms with the risk and severity of chronic heart failure: a case-control study of a northern Chinese population.
abstract: The causes of chronic heart failure (CHF) and its progression are likely to be due to complex genetic factors. Adenosine receptors A2A and A2B (ADORA2A and ADORA2B, respectively) play an important role in cardio-protection. Therefore, polymorphisms in the genes encoding those receptors may affect the risk and severity of CHF. This study was a case-control comparative investigation of 300 northern Chinese Han CHF patients and 400 ethnicity-matched healthy controls. Four common single-nucleotide polymorphisms (SNPs) of ADORA2A (rs2236625, rs2236624, rs4822489, and rs5751876) and one SNP of ADORA2B (rs7208480) were genotyped and an association between SNPs and clinical outcomes was evaluated. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. The rs4822489 was significantly associated with the severity of CHF after adjustment for traditional cardiovascular risk factors (p = 0.040, OR = 1.912, 95% CI = 1.029-3.550). However, the five SNPs as well as the haplotypes were not found to be associated with CHF susceptibility. The findings of this study suggest that rs4822489 may contribute to the severity of CHF in the northern Chinese. However, further studies performed in larger populations and aimed at better defining the role of this gene are required.
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. zhaiyajing1991@163.com.
authors: Ya-Jing
authors: YJ
authors: Zhai
authors: Department of Cardiovascular Medicine, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. pingdoctor@163.com.
authors: Ping
authors: P
authors: Liu
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. hehairong19891989@126.com.
authors: Hai-Rong
authors: HR
authors: He
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. zhengxiaowei_1990@163.com.
authors: Xiao-Wei
authors: XW
authors: Zheng
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. wangyan910819@gmail.com.
authors: Yan
authors: Y
authors: Wang
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. yangqiangting12@126.com.
authors: Qian-Ting
authors: QT
authors: Yang
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. dongyalin@mail.xjtu.edu.cn.
authors: Ya-Lin
authors: YL
authors: Dong
authors: Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China. lujun2006@mail.xjtu.edu.cn.
authors: Jun
authors: J
authors: Lu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D002908:Chronic Disease; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006333:Heart Failure / Q000235:genetics* / Q000473:pathology; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D043704:Receptor, Adenosine A2B / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D043705:Receptor, Adenosine A2A; D043704:Receptor, Adenosine A2B
references: Circulation. 1995 Sep 1;92(5):1094-100
references: 7648652
references: Am J Cardiol. 1997 Jun 19;79(12A):2-10
references: 9223356
references: Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12467-72
references: 9356473
references: Mol Cell. 2006 Jul 7;23(1):61-70
references: 16797197
references: J Heart Lung Transplant. 2006 Oct;25(10):1241-6
references: 17045937
references: Nat Genet. 2007 Mar;39(3):347-51
references: 17293865
references: Am J Cardiol. 2007 Apr 15;99(8):1146-50
references: 17437745
references: Circulation. 2007 May 22;115(20):2621-7
references: 17485580
references: Circ Res. 2007 Jun 8;100(11):1643-9
references: 17478726
references: Cell Death Differ. 2007 Jul;14(7):1315-23
references: 17396131
references: Rheumatology (Oxford). 2008 Aug;47(8):1156-9
references: 18539621
references: Neuropsychopharmacology. 2008 Nov;33(12):2791-800
references: 18305461
references: J Allergy Clin Immunol. 2008 Dec;122(6):1119-1126.e7
references: 18962861
references: Curr Protoc Hum Genet. 2009 Jan;Chapter 2:Unit 2.12
references: 19170031
references: Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1141-9
references: 19218506
references: Neurobiol Dis. 2009 Sep;35(3):474-6
references: 19591938
references: Eur Child Adolesc Psychiatry. 2010 Jan;19(1):67-74
references: 19565319
references: Anesthesiology. 2009 Oct;111(4):904-15
references: 19741501
references: Neuropsychopharmacology. 2010 Aug;35(9):1973-83
references: 20520601
references: Eur Heart J. 2010 Sep;31(18):2280-90
references: 20693169
references: Biol Psychiatry. 2010 Oct 1;68(7):657-66
references: 20691427
references: Neurogenetics. 2010 Oct;11(4):435-9
references: 20512606
references: J Psychiatr Res. 2010 Oct;44(14):930-7
references: 20334879
references: Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2082-9
references: 20935155
references: Biochim Biophys Acta. 2011 May;1808(5):1329-39
references: 20546702
references: Adv Pharmacol. 2011;61:145-86
references: 21586359
references: Ophthalmic Res. 2011;46(1):1-8
references: 21088442
references: DNA Cell Biol. 2011 Nov;30(11):907-11
references: 21675873
references: Circulation. 2012 Jan 3;125(1):e2-e220
references: 22179539
references: J Am Coll Cardiol. 2012 Jan 17;59(3):222-31
references: 22240126
references: Curr Opin Crit Care. 2012 Apr;18(2):178-85
references: 22322265
references: Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):851-5
references: 22423036
references: Cancer Epidemiol. 2012 Jun;36(3):283-7
references: 22369735
references: Mol Vis. 2011;17:486-91
references: 22740769
references: Eur Heart J. 2012 Jul;33(14):1787-847
references: 22611136
references: Am J Respir Crit Care Med. 2012 Aug 15;186(4):359-68
references: 22679008
references: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:115-21
references: 22940476
references: J Mol Med (Berl). 2013 Feb;91(2):183-93
references: 23263788
references: J Mol Med (Berl). 2013 Feb;91(2):141-6
references: 23338058
references: Gene. 2013 May 1;519(2):260-5
references: 23481304
references: Anesthesiology. 2013 May;118(5):1001-4
references: 23360900
references: Biosystems. 2013 Oct;114(1):31-8
references: 23850531
references: JACC Heart Fail. 2013 Dec;1(6):540-7
references: 24622007
references: JACC Cardiovasc Interv. 2014 Jun;7(6):581-91
references: 24835328
references: Nucleic Acids Res. 2001 Jan 1;29(1):308-11
references: 11125122
references: Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1035-40
references: 11834501
references: Circulation. 1986 Oct;74(4):843-51
references: 3093117
references: J Cardiovasc Pharmacol. 1993 Jul;22(1):89-96
references: 7690102
references: Circulation. 1995 Jun 15;91(12):2891-7
references: 7796497