title: Two new triterpenoids from fruiting bodies of fungus Ganoderma lucidum.
abstract: Two new triterpenoids, (24E)-9α,11α-epoxy-3β-hydroxylanosta-7,24-dien-26-al (1) and (22Z,24Z)-13-hydroxy-3-oxo-14(13 → 12)abeo-lanosta-8,22,24-trien-26,23-olide (2) were isolated from dried fruiting bodies of fungus Ganoderma lucidum. The structures of these two new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 1 possessed a lanostane skeleton, while compound 2 was based on a rare 14 (13 → 12)abeo-lanostane skeleton with a 26,23-olide moiety. Both of them were evaluated for their antifungal and cytotoxic activities. Neither of them displayed obvious inhibition on Candida albicans and five human cancer cell lines.
authors: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors: Zhen-Zhu
authors: ZZ
authors: Zhao
authors: Rong-Hua
authors: RH
authors: Yin
authors: He-Ping
authors: HP
authors: Chen
authors: Tao
authors: T
authors: Feng
authors: Zheng-Hui
authors: ZH
authors: Li
authors: Ze-Jun
authors: ZJ
authors: Dong
authors: Bao-Kai
authors: BK
authors: Cui
authors: Ji-Kai
authors: JK
authors: Liu
mesh_terms: D002176:Candida albicans / Q000187:drug effects; D002681:China; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000602403:(22Z,24Z)-13-hydroxy-3-oxo-14(13-12)abeo-lanosta-8,22,24-trien-26,23-olide; C000602401:(24E)-9alpha,11alpha-epoxy-3beta-hydroxylanosta-7,24-dien-26-al; D014315:Triterpenes
keywords: 14 (13 → 12)abeo-lanostane; Ganoderma lucidum; triterpenoid