title: Interleukin 23 levels are increased in carotid atherosclerosis: possible role for the interleukin 23/interleukin 17 axis.
abstract: OBJECTIVE
  Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with a central role in inflammation. We hypothesize that IL-23 is also important in atherogenesis and investigate this in a population with carotid atherosclerosis.
  
  
  METHODS
  Plasma levels of IL-23 were measured in patients with carotid artery stenosis and in healthy controls. The mRNA levels of IL-23 and its receptor, IL-23R, were measured in atherosclerotic plaques, nonatherosclerotic vessels, peripheral blood mononuclear cells, and plasmacytoid dendritic cells.
  
  
  RESULTS
  Our findings were as follows: (1) patients with carotid atherosclerosis (n=177) had significantly raised plasma levels of IL-23 when compared with healthy controls (n=24) with particularly high levels in those with the most recent symptoms. (2) mRNA levels of IL-23 and IL-23R were markedly increased in carotid plaques (n=68) when compared with nonatherosclerotic vessels (n=8-10). Immunostaining showed colocalization to plaque macrophages. (3) Patients with carotid atherosclerosis had increased mRNA levels of both IL-23 and IL-23R in plasmacytoid dendritic cells, but not in peripheral blood mononuclear cells. (4) IL-23 increased IL-17 release in monocytes and particularly in peripheral blood mononuclear cells from patients with carotid atherosclerosis, but not in cells from healthy controls. (5) IL-23 gave a prominent tumor necrosis factor release in monocytes from patients with carotid atherosclerosis but not in cells from healthy controls. (6) High plasma levels of IL-23 were associated with increased mortality during follow-up.
  
  
  CONCLUSIONS
  We have shown an association between IL-23 and disease progression in patients with carotid atherosclerosis, potentially involving IL-17-related mechanisms.
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Azhar
authors: A
authors: Abbas
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Ida
authors: I
authors: Gregersen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Sverre
authors: S
authors: Holm
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Isabelle
authors: I
authors: Daissormont
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Vigdis
authors: V
authors: Bjerkeli
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Kirsten
authors: K
authors: Krohg-Sørensen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Karolina R
authors: KR
authors: Skagen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Tuva B
authors: TB
authors: Dahl
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: David
authors: D
authors: Russell
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Trine
authors: T
authors: Almås
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Dorte
authors: D
authors: Bundgaard
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Lars Holger
authors: LH
authors: Alteheld
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Azita
authors: A
authors: Rashidi
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Christen P
authors: CP
authors: Dahl
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Annika E
authors: AE
authors: Michelsen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Erik A
authors: EA
authors: Biessen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Pål
authors: P
authors: Aukrust
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.). bente.halvorsen@rr-research.no.
authors: Bente
authors: B
authors: Halvorsen
authors: From the Research Institute of Internal Medicine (A.A., I.G., S.H., V.B., T.B.D., A.R., C.P.D., A.E.M., P.A., B.H.), Department of Neurology (A.A., K.R.S., D.R., M.S.), Department of Thoracic and Cardiovascular Surgery (K.K.-S.), Department of Cardiology (C.P.D.), and Section of Clinical Immunology and Infectious Diseases (P.A.), Oslo University Hospital Rikshospitalet Oslo, Norway; Department of Neurology, Oslo University Hospital, Ullevål, Norway (L.H.A.); Institute of Clinical Medicine (A.A., I.G., V.B., K.K.-S., T.B.D., D.R., A.E.M., P.A., B.H.), K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research (C.P.D.), K.G. Jebsen Inflammation Research Centre (P.A., B.H.), University of Oslo, Oslo, Norway; Department of Neurology (T.A.), Department of Thoracic and Cardiovascular Surgery (D.B.), Østfold Hospital Trust, Fredrikstad, Norway; and Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands (I.D., E.A.B.).
authors: Mona
authors: M
authors: Skjelland
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000097:blood* / Q000378:metabolism; D016893:Carotid Stenosis / Q000097:blood* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018123:Receptors, Interleukin / Q000097:blood; D020521:Stroke / Q000097:blood
chemical_list: C515500:IL23R protein, human; D020381:Interleukin-17; D053759:Interleukin-23; D012333:RNA, Messenger; D018123:Receptors, Interleukin
keywords: atherosclerosis; carotid stenosis; inflammation; interleukins