title: Serum soluble tumour necrosis factor related apoptosis-inducing ligand level and peripheral eosinophil count in patients with nasal polyposis.
abstract: BACKGROUND
  Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. Eosinophilic inflammation plays an important role in the pathogenesis. This study aimed to investigate soluble tumour necrosis factor related apoptosis-inducing ligand levels and eosinophil count in nasal polyposis patients.
  
  
  METHODS
  The study was performed on 24 adult nasal polyposis patients and 24 age-matched healthy individuals. The patients had not received any medical or surgical treatment. Pre-operative computed tomography scans were assessed using the Lund-MacKay grading system, and soluble tumour necrosis factor related apoptosis-inducing ligand levels were measured with a sandwich enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Compared with controls, eosinophil levels in nasal polyposis patients were increased (p = 0.024), but there was no significant difference in soluble tumour necrosis factor related apoptosis-inducing ligand levels (p = 0.529). The Lund-MacKay mean grading was 12.43 ± 6.9. There was no correlation between soluble tumour necrosis factor related apoptosis-inducing ligand level and Lund-MacKay grading and eosinophil count.
  
  
  CONCLUSIONS
  There was no relationship between soluble tumour necrosis factor related apoptosis-inducing ligand level and blood eosinophil or clinical markers; however, soluble tumour necrosis factor related apoptosis-inducing ligand level remains of interest for future studies.
authors: Medical Genetics Department of Balcali Clinics and Hospitals,Faculty of Medicine,Cukurova University,Adana,Turkey.
authors: A
authors: A
authors: Bisgin
authors: Department of Otorhinolaryngology,Antalya Training and Research Hospital,Turkey.
authors: H
authors: H
authors: Eyigor
authors: Department of Otorhinolaryngology,Antalya Training and Research Hospital,Turkey.
authors: U
authors: U
authors: Osma
authors: Department of Otorhinolaryngology,Antalya Training and Research Hospital,Turkey.
authors: M D
authors: MD
authors: Yilmaz
authors: Department of Internal Medicine,Allergy and Clinical Immunology Unit,Antalya Training and Research Hospital,Turkey.
authors: A D
authors: AD
authors: Yalcin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000097:blood* / Q000473:pathology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*
chemical_list: D015415:Biomarkers; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human
keywords: Biological Markers