title: Association between Glucose Levels and Intraocular Pressure: Pre- and Postprandial Analysis in Diabetic and Nondiabetic Patients.
abstract: The aim of this study was to evaluate the relationship between glucose levels and intraocular pressure (IOP) fluctuation in diabetic and nondiabetic patients. Seventeen nondiabetic and 20 diabetic subjects underwent a complete ophthalmic examination, capillary glucose testing, and applanation tonometry in two distinct situations: first, fasting for at least 8 hours and, second, postprandial measurements. Baseline glucose levels were higher in diabetic patients (P < 0.001). Postprandial IOP was significantly higher than baseline IOP in diabetic (P < 0.001) and nondiabetic patients (P = 0.006). Postprandial glucose levels were significantly higher than baseline measurements in both diabetic (P = 0.005) and nondiabetic patients (P = 0.015). There was a significant association between glucose levels variation and IOP change in both diabetic patients (R (2) = 0.540; P < 0.001) and nondiabetic individuals (R (2) = 0.291; P = 0.025). There is also a significant association between the baseline glucose levels and IOP change in diabetic group (R (2) = 0.445; P = 0.001). In a multivariable model, the magnitude of glucose level change remained significantly associated with IOP variation even including age, baseline IOP, ancestry, and gender as a confounding factor (P < 0.001). We concluded that there is a significant association between blood glucose levels and IOP variation, especially in diabetic patients.
authors: Department of Ophthalmology, Federal University of São Paulo, 04021-001 Vila Mariana, SP, Brazil.
authors: Luis Guilherme Milesi
authors: LG
authors: Pimentel
authors: Department of Ophthalmology, Federal University of São Paulo, 04021-001 Vila Mariana, SP, Brazil.
authors: Carolina P B
authors: CP
authors: Gracitelli
authors: Department of Ophthalmology, Federal University of São Paulo, 04021-001 Vila Mariana, SP, Brazil.
authors: Leticia Sant'Ana Cardoso
authors: LS
authors: da Silva
authors: Department of Ophthalmology, Federal University of São Paulo, 04021-001 Vila Mariana, SP, Brazil.
authors: Aline Katia Siqueira
authors: AK
authors: Souza
authors: Department of Ophthalmology, Federal University of São Paulo, 04021-001 Vila Mariana, SP, Brazil ; Glaucoma Unit, Hospital Medicina dos Olhos, 06018-180 Osasco, SP, Brazil.
authors: Tiago Santos
authors: TS
authors: Prata
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