title: Visual-functional mismatch and results of fractional flow reserve guided percutaneous coronary revascularization.
abstract: OBJECTIVE
  To identify mismatches in the significance ofcoronary artery stenosis determined by physician 's visual estimation (VE) vs. quantitative coronary angiography (QCA), by VE vs. fractional flow reserve (FFR), and independent predictors for mismatch between VE and FFR. Second objective was to evaluate the clinical outcomes ofpatients receiving FFR-guided percutaneous coronary intervention (PCI).
  
  
  METHODS
  Two hundreds eighty consecutive patients (338 coronary lesions including non-left main (non-LM) 316 lesions and left main (LM) 22 lesions) underwent coronary angiography, offline edge detection QCA, and FFR measurement between August 2011 and December 2013 were included in the present study. Baseline patient data, lesion characteristics, and clinical outcomes were recorded and analyzed. Coronary lesions were then divided into four groups according to FFR results and treatment (FFR <0.75 and PCI, FFR 0.75-0.80 and PCI, FFR 0.75-0.80 and defer PCI, FFR >0.80 and defer PCI). Mismatches in the significance of coronary artery stenosis determined by VE vs. QCA, VE vs. FFR, independent predictors of VE-FFR mismatch, and clinical outcomes after FFR-guided treatment were reported.
  
  
  RESULTS
  Lesions with VE-QCA mismatch were seen in 64% of non-LM lesions and in 87% of the LM lesions. Conversely, lesions with VE-QCA reverse mismatch were seen in 13% of non-LM lesions and in 0% of the LM lesions. Lesions with VE-FFR mismatch were seen in 42% of non-LM lesions and in 53% of the LM lesions. Lesions with VE-FFR reverse mismatch were seen in 15% of non-LM lesions and in 14% of the LM lesions. The independent predictors for VE-FFR mismatch in non-LM lesions were shorter lesion and greater minimal lumen diameter. After FFR guided-treatment and dividing coronary lesions into four groups, all patients were followed-up for a median period of 11.6 (IQR; 7.3, 17.6) months. Major adverse cardiovascular events (excluded one death) of 338 lesions were not significantly different in the four groups (1.7% vs. 5.1% vs. 5.3% vs. 2.7%, p = 0.717). The median cost ofprocedure of lesions undergone FFR plus additional PCI was significantly higher than lesions undergone FFR only (140,000 vs. 137,000 vs. 45,000 vs. 45,000 Baht, p<0.001).
  
  
  CONCLUSIONS
  Mismatches between visually-estimated significance of angiographic coronary stenosis and QCA or FFR are frequently encountered. Visual estimation of coronary angiography alone cannot entirely predict functional significance of coronary stenosis. FFR measurement provides a helpful strategy for decision making before further revascularization.
authors: Thamarath
authors: T
authors: Chantadansuwan
authors: Wirash
authors: W
authors: Kehasukcharoen
authors: Anek
authors: A
authors: Kanoksilp
authors: Boonjong
authors: B
authors: Saejueng
authors: Vathanyoo
authors: V
authors: Plainetr
authors: Narin
authors: N
authors: Sukhavasharin
authors: Sudaratana
authors: S
authors: Tansuphaswadikul
authors: Kriengkrai
authors: K
authors: Hengrussamee
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D017063:Outcome Assessment, Health Care; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012720:Severity of Illness Index; D013785:Thailand; D016896:Treatment Outcome