title: [Hepatitis E virus].
abstract: HEV is a small non-enveloped RNA virus that is associated to lipids in the blood of infected individuals. The genera Orthohepevirus recently proposed includes the zoonotic mammals strains. The other strains of the family Hepeviridae are not transmissible to humans. The diagnosis of HEV infection should be considered in any patient with serum ALT elevation. The diagnosis of HEV infection in immunocompetent patients relies on detecting IgM antibodies in the blood. The diagnosis of HEV infection in immunosuppressed patients relies on detecting IgM antibodies and HEV RNA in the blood. Ribavirin inhibits HEV replication via a mechanism of action that is still unknown.
authors: Hôpital de Purpan, CHU de Toulouse, institut fédératif de biologie, laboratoire de virologie, CNR hépatite E, 330, avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse cedex 9, France; Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, centre de physiopathologie de Toulouse-Purpan, 31024 Toulouse cedex 03, France. Electronic address: izopet.j@chu-toulouse.fr.
authors: Jacques
authors: J
authors: Izopet
authors: Hôpital de Purpan, CHU de Toulouse, institut fédératif de biologie, laboratoire de virologie, CNR hépatite E, 330, avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse cedex 9, France; Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, centre de physiopathologie de Toulouse-Purpan, 31024 Toulouse cedex 03, France.
authors: Sébastien
authors: S
authors: Lhomme
authors: Hôpital de Purpan, CHU de Toulouse, institut fédératif de biologie, laboratoire de virologie, CNR hépatite E, 330, avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse cedex 9, France; Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, centre de physiopathologie de Toulouse-Purpan, 31024 Toulouse cedex 03, France.
authors: Florence
authors: F
authors: Abravanel
authors: AP-HP, hôpital Brousse, centre hépato-biliaire, CNR hépatite A, 94800 Villejuif, France; Université Paris-Sud, unité mixte de recherche scientifique 785, 92296 Chatenay-Malabry, France; Inserm unité 785, 94800 Villejuif, France.
authors: Anne-Marie
authors: AM
authors: Roque
authors: Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, centre de physiopathologie de Toulouse-Purpan, 31024 Toulouse cedex 03, France; CHU de Toulouse, département de néphrologie et transplantation d'organes, 31059 Toulouse cedex 9, France.
authors: Nassim
authors: N
authors: Kamar
mesh_terms: D000465:Algorithms; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D016751:Hepatitis E / Q000175:diagnosis / Q000821:virology; D016752:Hepatitis E virus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D012254:Ribavirin / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin