title: Peak weight and height velocity to age 36 months and asthma development: the Norwegian Mother and Child Cohort Study.
abstract: BACKGROUND
  The immediate postnatal period is the period of the fastest growth in the entire life span and a critical period for lung development. Therefore, it is interesting to examine the association between growth during this period and childhood respiratory disorders.
  
  
  METHODS
  We examined the association of peak weight and height velocity to age 36 months with maternal report of current asthma at 36 months (n = 50,311), recurrent lower respiratory tract infections (LRTIs) by 36 months (n = 47,905) and current asthma at 7 years (n = 24,827) in the Norwegian Mother and Child Cohort Study. Peak weight and height velocity was calculated using the Reed1 model through multilevel mixed-effects linear regression. Multivariable log-binomial regression was used to calculate adjusted relative risks (adj.RR) and 95% confidence intervals (CI). We also conducted a sibling pair analysis using conditional logistic regression.
  
  
  RESULTS
  Peak weight velocity was positively associated with current asthma at 36 months [adj.RR 1.22 (95%CI: 1.18, 1.26) per standard deviation (SD) increase], recurrent LRTIs by 36 months [adj.RR 1.14 (1.10, 1.19) per SD increase] and current asthma at 7 years [adj.RR 1.13 (95%CI: 1.07, 1.19) per SD increase]. Peak height velocity was not associated with any of the respiratory disorders. The positive association of peak weight velocity and asthma at 36 months remained in the sibling pair analysis.
  
  
  CONCLUSIONS
  Higher peak weight velocity, achieved during the immediate postnatal period, increased the risk of respiratory disorders. This might be explained by an influence on neonatal lung development, shared genetic/epigenetic mechanisms and/or environmental factors.
authors: Department of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
authors: Maria C
authors: MC
authors: Magnus
authors: Department of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway; Department of Community Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
authors: Hein
authors: H
authors: Stigum
authors: Institute Management and Staff, Norwegian Institute of Public Health, Oslo, Norway.
authors: Siri E
authors: SE
authors: Håberg
authors: Department of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway; Department of Community Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
authors: Per
authors: P
authors: Nafstad
authors: Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America.
authors: Stephanie J
authors: SJ
authors: London
authors: Department of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
authors: Wenche
authors: W
authors: Nystad
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009035:Mothers; D009664:Norway; D018401:Sample Size; D035781:Siblings
references: Am J Respir Crit Care Med. 2012 Jun 1;185(11):1183-9
references: 22461370
references: Eur J Endocrinol. 2011 Oct;165(4):623-30
references: 21775498
references: Thorax. 2010 Dec;65(12):1099-106
references: 20956394
references: Thorax. 2005 Jul;60(7):549-54
references: 15994261
references: Int J Epidemiol. 2006 Oct;35(5):1146-50
references: 16926217
references: Epidemiology. 2013 Sep;24(5):660-70
references: 23867813
references: Am J Respir Crit Care Med. 2010 Feb 15;181(4):328-36
references: 19926868
references: Am J Epidemiol. 2008 Jul 15;168(2):170-8
references: 18511427
references: Clin Respir J. 2011 Oct;5(4):211-8
references: 21801323
references: Am J Respir Crit Care Med. 2011 Aug 15;184(4):407-13
references: 21642247
references: Am J Hum Biol. 1992;4(3):327-335
references: 28524294
references: Pediatr Allergy Immunol. 2005 Aug;16(5):380-5
references: 16101929
references: World Rev Nutr Diet. 2013;106:33-8
references: 23428678
references: Pediatr Allergy Immunol. 2013 Mar;24(2):122-30
references: 23374010
references: Hum Biol. 1987 Dec;59(6):973-87
references: 3443447
references: Allergy. 2012 May;67(5):670-5
references: 22381045
references: Paediatr Perinat Epidemiol. 2011 Nov;25(6):507-18
references: 21980940
references: J Allergy Clin Immunol. 2014 May;133(5):1317-29
references: 24529685
references: Clin Exp Allergy. 2012 Oct;42(10):1430-47
references: 22994341
references: Eur J Clin Nutr. 2013 Oct;67(10 ):1029-35
references: 24002042
references: Allergy. 2012 Jun;67(6):767-74
references: 22469062
references: J Allergy Clin Immunol. 2013 Jun;131(6):1528-36
references: 23403049
references: J Clin Epidemiol. 2011 Aug;64(8):878-84
references: 21232920
references: Pathology. 2008 Feb;40(2):124-40
references: 18203035
references: Curr Opin Allergy Clin Immunol. 2013 Apr;13(2):193-202
references: 23407123
references: Int J Obes (Lond). 2006 Jan;30(1):6-13
references: 16344843
references: J Allergy Clin Immunol. 2009 Jun;123(6):1312-8.e2
references: 19409606
references: Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 1):82-9
references: 19725894
references: J Allergy Clin Immunol. 2011 Jan;127(1):262-4, 264.e1
references: 21094522
references: J Allergy Clin Immunol. 2008 May;121(5):1161-1166.e3
references: 18466784
references: Chest. 2006 Jul;130(1 Suppl):4S-12S
references: 16840363
references: J Allergy Clin Immunol. 2009 Mar;123(3):651-7, 657.e1-4
references: 19152964
references: Environ Health Perspect. 2012 Feb;120(2):162-70
references: 21997443
references: Pediatr Pulmonol. 2001 Sep;32(3):201-10
references: 11536449
references: N Engl J Med. 2008 Jul 3;359(1):61-73
references: 18596274
references: Allergy. 2012 Feb;67(2):257-64
references: 22092112
references: Dev Cell. 2010 Jan 19;18(1):8-23
references: 20152174
references: Arch Dis Child. 2009 Mar;94(3):180-4
references: 19052032
references: Environ Health Perspect. 2012 Oct;120(10 ):1425-31
references: 22851337
references: Am J Epidemiol. 2014 Apr 1;179(7):834-42
references: 24561991
references: Am J Respir Crit Care Med. 2012 Apr 1;185(7):731-7
references: 22268138
references: Epidemiology. 2012 Sep;23(5):713-20
references: 22781362
references: Environ Health Perspect. 2014 Jan;122(1):93-9
references: 24162035
references: Arch Dis Child. 2009 May;94(5):333-6
references: 19147620
references: Ann Hum Biol. 2014 Mar-Apr;41(2):168-79
references: 24111514
references: Eur Respir J. 2012 Feb;39(2):403-10
references: 21852338
references: Paediatr Perinat Epidemiol. 2009 Nov;23(6):597-608
references: 19840297