title: Effect of physical activity assessment on prognostication for peripheral artery disease and mortality.
abstract: OBJECTIVE
  To examine whether a simple question about the performance of regular vigorous activity is associated with peripheral artery disease (PAD) and mortality.
  
  
  METHODS
  A total of 1288 individuals undergoing nonemergency coronary angiography were assessed for participation in regular vigorous activity by questionnaire. Data on demographic characteristics, ankle-brachial indexes, and cardiovascular outcomes were prospectively collected.
  
  
  RESULTS
  Compared with those who denied participation in regular vigorous activity, those who reported participation were less likely to have PAD (odds ratio, 0.58; 95% CI, 0.39-0.86), had higher ankle-brachial indexes, had better Walking Impairment Questionnaire scores (P<.001), and experienced reduced all-cause mortality rates (hazard ratio, 0.48; 95% CI, 0.31-0.74). When added to the Framingham Risk Score, the response improved the net reclassification index for all-cause (32.6%) and cardiovascular (32.0%) mortality.
  
  
  CONCLUSIONS
  Among at-risk individuals, regular vigorous activity is associated with decreased PAD and all-cause mortality. Simple and readily available, a single yes/no query about participation in regular vigorous exercise could be used to improve risk stratification.
authors: National University Heart Centre, Singapore.
authors: Peter
authors: P
authors: Chang
authors: Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA.
authors: Kevin T
authors: KT
authors: Nead
authors: The Icahn School of Medicine at Mount Sinai, Mount Sinai School of Medicine, New York, NY.
authors: Jeffrey W
authors: JW
authors: Olin
authors: Cardiology Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.
authors: Jonathan
authors: J
authors: Myers
authors: Methodist Hospital Research Institute, Houston, TX.
authors: John P
authors: JP
authors: Cooke
authors: Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA; Stanford Cardiovascular Institute, Stanford, CA. Electronic address: nleeper@stanford.edu.
authors: Nicholas J
authors: NJ
authors: Leeper
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001157:Arterial Occlusive Diseases / Q000401:mortality* / Q000534:rehabilitation*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D051346:Mobility Limitation; D009043:Motor Activity; D016491:Peripheral Vascular Diseases / Q000401:mortality* / Q000534:rehabilitation*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
references: Circulation. 2011 Feb 8;123(5):551-65
references: 21300963
references: Circulation. 2010 Aug 24;122(8):790-7
references: 20697029
references: Arch Intern Med. 2012 Jul 23;172(14):1096-102
references: 22710902
references: Circ Cardiovasc Genet. 2009 Aug;2(4):347-53
references: 20031606
references: Circulation. 2012 Apr 10;125(14):1748-56, S1-11
references: 22399535
references: J Am Geriatr Soc. 1994 Sep;42(9):923-9
references: 8064098
references: Circulation. 2007 Sep 18;116(12):1396-403
references: 17724262
references: Circulation. 2005 Nov 29;112(22):3501-8
references: 16316971
references: J Vasc Surg. 2013 Mar;57(3):728-33
references: 23044259
references: JAMA. 2009 May 20;301(19):2024-35
references: 19454641
references: Am Heart J. 2006 Apr;151(4):890.e1-7
references: 16569555
references: N Engl J Med. 2000 Sep 21;343(12):826-33
references: 10995861
references: J Vasc Surg. 2011 Aug;54(2):427-32, 432.e1-4
references: 21664093
references: J Am Coll Cardiol. 2011 Feb 22;57(8):962-70
references: 21329843
references: Am J Prev Med. 2005 Oct;29(3):194-203
references: 16168868
references: Circ Cardiovasc Qual Outcomes. 2013 May 1;6(3):255-61
references: 23633217
references: Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):102-14
references: 15785295
references: Circulation. 2006 Feb 14;113(6):791-8
references: 16461820
references: J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2960-84
references: 24239922
references: Am J Cardiol. 1990 Jul 15;66(2):172-8
references: 2371947
references: N Engl J Med. 2002 Mar 14;346(11):793-801
references: 11893790
references: Prog Cardiovasc Dis. 2005 Jan-Feb;47(4):285-305
references: 15991156
references: Circulation. 2006 Jul 18;114(3):242-8
references: 16818814
references: Am J Med. 2004 Dec 15;117(12):912-8
references: 15629729
references: Eur Heart J. 2003 Jun;24(11):987-1003
references: 12788299
references: J Cardiopulm Rehabil. 2002 Nov-Dec;22(6):399-407
references: 12464826
references: J Vasc Surg. 2012 Jun;55(6):1662-73.e2
references: 22608041
references: J Am Coll Cardiol. 2010 Jun 22;55(25):2816-21
references: 20579537
references: J Am Coll Cardiol. 2010 May 11;55(19):2017-23
references: 20447524
references: N Engl J Med. 1986 Mar 6;314(10):605-13
references: 3945246
references: Am J Epidemiol. 1988 Jan;127(1):87-94
references: 3337078
references: J Am Coll Cardiol. 2012 Jan 17;59(3):294-357
references: 22153885
references: Eur J Vasc Endovasc Surg. 2011 Jan;41(1):104-9
references: 21123095
references: Vasc Med. 2010 Dec;15(6):443-50
references: 21183651
references: J Am Coll Cardiol. 2008 Apr 15;51(15):1482-9
references: 18402904
references: Br J Prev Soc Med. 1977 Mar;31(1):42-8
references: 856370
references: JAMA. 2007 Mar 21;297(11):1197-206
references: 17374814
references: Stat Med. 2011 Jan 15;30(1):11-21
references: 21204120