title: Development of functional in vivo imaging of cerebral lenticulostriate artery using novel synchrotron radiation angiography.
abstract: The lenticulostriate artery plays a vital role in the onset and development of cerebral ischemia. However, current imaging techniques cannot assess the in vivo functioning of small arteries such as the lenticulostriate artery in the brain of rats. Here, we report a novel method to achieve a high resolution multi-functional imaging of the cerebrovascular system using synchrotron radiation angiography, which is based on spatio-temporal analysis of contrast density in the arterial cross section. This method provides a unique tool for studying the sub-cortical vascular elasticity after cerebral ischemia in rats. Using this technique, we demonstrated that the vascular elasticity of the lenticulostriate artery decreased from day 1 to day 7 after transient middle cerebral artery occlusion in rats and recovered from day 7 to day 28 compared to the controls (p < 0.001), which paralleled with brain edema formation and inversely correlated with blood flow velocity (p < 0.05). Our results demonstrated that the change of vascular elasticity was related to the levels of brain edema and the velocity of focal blood flow, suggesting that reducing brain edema is important for the improvement of the function of the lenticulostriate artery in the ischemic brain.
authors: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.
authors: Xiaojie
authors: X
authors: Lin
authors: Peng
authors: P
authors: Miao
authors: Zhihao
authors: Z
authors: Mu
authors: Zhen
authors: Z
authors: Jiang
authors: Yifan
authors: Y
authors: Lu
authors: Yongjing
authors: Y
authors: Guan
authors: Xiaoyan
authors: X
authors: Chen
authors: Tiqiao
authors: T
authors: Xiao
authors: Yongting
authors: Y
authors: Wang
authors: Guo-Yuan
authors: GY
authors: Yang
mesh_terms: D000818:Animals; D002533:Cerebral Angiography / Q000295:instrumentation / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017356:Synchrotrons