title: Circadian clock genes: effects on dopamine, reward and addiction.
abstract: Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.
authors: University of Pittsburgh School of Medicine, Department of Psychiatry, 450 Technology Drive, Suite 223, Pittsburgh, PA 15219, USA.
authors: Puja K
authors: PK
authors: Parekh
authors: University of Pittsburgh School of Medicine, Department of Psychiatry, 450 Technology Drive, Suite 223, Pittsburgh, PA 15219, USA; Portland Veterans Affairs Medical Center, Research and Development Service, Portland, OR 97239, USA; Oregon Health and Science University, Department of Behavioral Neuroscience, Portland, OR 97239, USA.
authors: Angela R
authors: AR
authors: Ozburn
authors: University of Pittsburgh School of Medicine, Department of Psychiatry, 450 Technology Drive, Suite 223, Pittsburgh, PA 15219, USA. Electronic address: mcclungca@upmc.edu.
authors: Colleen A
authors: CA
authors: McClung
mesh_terms: D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000494:pharmacology; D057906:Circadian Clocks / Q000187:drug effects / Q000235:genetics*; D002940:Circadian Rhythm / Q000187:drug effects / Q000235:genetics*; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000187:drug effects / Q000235:genetics*; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism*; D012201:Reward; D019966:Substance-Related Disorders / Q000235:genetics / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D056925:Circadian Rhythm Signaling Peptides and Proteins; D000431:Ethanol; D004298:Dopamine
keywords: Addiction; Alcohol; Circadian; Dopamine
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