title: Bioethical conflicts of gene therapy: a brief critical review.
abstract: Methods and techniques employed in gene therapy are reviewed in parallel with pertinent ethical conflicts. Clinical interventions based on gene therapy techniques preferentially use vectors for the transportation of therapeutic genes, however little is known about the potential risks and damages to the patient. Thus, attending carefully to the clinical complications arising as well as to security is essential. Despite the scientific and technological advances, there are still many uncertainties about the side effects of gene therapy. Moreover, there is a need, above all, to understand the principles of bioethics as both science and ethics, in accordance with its socioecological responsibility, in order to prioritize the health and welfare of man and nature, using properly natural resources and technology. Therefore, it is hard to determine objective results and to which extent the insertion of genes can affect the organism, as well as the ethical implication.
authors: Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: José Ednésio da Cruz
authors: JE
authors: Freire
authors: Department of Clinical and Toxicology Analysis, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Suelen Carneiro de
authors: SC
authors: Medeiros
authors: Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Antônio Viana
authors: AV
authors: Lopes Neto
authors: Biology Department, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: José Edvar
authors: JE
authors: Monteiro Júnior
authors: Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Antônio Juscelino Sudário
authors: AJ
authors: Sousa
authors: Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Antônio José
authors: AJ
authors: Rocha
authors: Faculty of Pharmacy, Odontology and Nursing, Federal University of Ceará, Fortaleza, CE, Brazil.
authors: Léa Maria Bezerra de
authors: LM
authors: Menezes
mesh_terms: D001291:Attitude of Health Personnel; D026688:Bioethical Issues; D018014:Gene Transfer Techniques / Q000941:ethics*; D015316:Genetic Therapy / Q000941:ethics*; D006801:Humans; D061214:Patient Safety; D018570:Risk Assessment / Q000592:standards; D012941:Social Responsibility