title: Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population.
abstract: BACKGROUND
  Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis.
  
  
  RESULTS
  The study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering GNPTAB, GNPTG and NAGPA were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB and rs882294 in NAGPA with developmental dyslexia was identified after FDR correction for multiple comparisons.
  
  
  CONCLUSIONS
  Our results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population.
authors: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, 102206, China. chenhuansym@163.com.
authors: Huan
authors: H
authors: Chen
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. jqxu@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. jqxu@capitalbio.com.
authors: Junquan
authors: J
authors: Xu
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. yuxizhou@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. yuxizhou@capitalbio.com.
authors: Yuxi
authors: Y
authors: Zhou
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. yonggao@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. yonggao@capitalbio.com.
authors: Yong
authors: Y
authors: Gao
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. gqwang@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. gqwang@capitalbio.com.
authors: Guoqing
authors: G
authors: Wang
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. jiguangxia@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. jiguangxia@capitalbio.com.
authors: Jiguang
authors: J
authors: Xia
authors: Department of Anatomy, The University of Hong Kong, Hong Kong, China. msyhuen@hku.hk.
authors: Michael S Y
authors: MS
authors: Huen
authors: State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China. siok@hku.hk.|School of Humanities, The University of Hong Kong, Hong Kong, China. siok@hku.hk.
authors: Wai Ting
authors: WT
authors: Siok
authors: The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. jiangyy@sz.tsinghua.edu.cn.
authors: Yuyang
authors: Y
authors: Jiang
authors: Neuroimaging Laboratory, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, China. lihaitan@gmail.com.|Guangdong Key Laboratory of Biomedical Information Detection and Ultrasound Imaging, Shenzhen, 518060, China. lihaitan@gmail.com.
authors: Li Hai
authors: LH
authors: Tan
authors: National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China. ymsun@capitalbio.com.|CapitalBio Corporation, Beijing, 102206, China. ymsun@capitalbio.com.|The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. ymsun@capitalbio.com.|Medical Systems Biology Research Center, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China. ymsun@capitalbio.com.
authors: Yimin
authors: Y
authors: Sun
mesh_terms: D044466:Asian People / Q000235:genetics*; D015331:Cohort Studies; D004410:Dyslexia / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D013342:Stuttering / Q000235:genetics*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics*
chemical_list: D017855:Transferases (Other Substituted Phosphate Groups); C511050:GNPTAB protein, human; C504791:GNPTG protein, human; D010727:Phosphoric Diester Hydrolases; C026645:N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
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