title: MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9.
abstract: Aberrant expression of miR-204 had been frequently reported in cancer studies; however, the mechanism of its function in retinoblastoma remained unknown. Here, we reported that miR-204 was frequently downregulated in retinoblastoma tissues and cell lines. Enforced expression of miR-204 inhibited retinoblastoma cells' proliferation and invasion. In vivo study indicated that restoration of miR-204 inhibited tumor growth. CyclinD2 and MMP-9 were identified as potential targets of miR-204. In addition, a reverse correlation between miR-204 and CyclinD2 or MMP-9 expression was noted in retinoblastoma tissues. Taken together, our results identified a crucial tumor suppressive role of miR-204 in the progression of retinoblastoma.
authors: Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors: XianJin
authors: X
authors: Wu
authors: Orthopedic Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors: Yong
authors: Y
authors: Zeng
authors: Orthopedic Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors: ShaoKe
authors: S
authors: Wu
authors: Oncology Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors: JiXin
authors: J
authors: Zhong
authors: Oncology Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China.
authors: YuZhou
authors: Y
authors: Wang
authors: Institute of Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical College, Dongguan, Guangdong, People's Republic of China. Electronic address: junfaxu001@126.com.
authors: JunFa
authors: J
authors: Xu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology*; D056742:Cyclin D2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology*; D060888:Real-Time Polymerase Chain Reaction; D012175:Retinoblastoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy
chemical_list: D056742:Cyclin D2; C549404:MIRN204 microRNA, human; D035683:MicroRNAs; D020780:Matrix Metalloproteinase 9
keywords: CyclinD2; MMP-9; Retinoblastoma; miR-204