title: Design, Properties, and In Vivo Behavior of Super-paramagnetic Persistent Luminescence Nanohybrids.
abstract: With the fast development of noninvasive diagnosis, the design of multimodal imaging probes has become a promising challenge. If many monofunctional nanocarriers have already proven their efficiency, only few multifunctional nanoprobes have been able to combine the advantages of diverse imaging modalities. An innovative nanoprobe called mesoporous persistent luminescence magnetic nanohybrids (MPNHs) is described that shows both optical and magnetic resonance imaging (MRI) properties intended for in vivo multimodal imaging in small animals. MPNHs are based on the assembly of chromium-doped zinc gallate oxide and ultrasmall superparamagnetic iron oxide nanoparticles embedded in a mesoporous silica shell. MPNHs combine the optical advantages of persistent luminescence, such as real time imaging with highly sensitive and photostable detection, and MRI negative contrast properties that ensure in vivo imaging with rather high spatial resolution. In addition to their imaging capabilities, these MPNHs can be motioned in vitro with a magnet, which opens multiple perspectives in magnetic vectorization and cell therapy research.
authors: Unité des Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, F-75270, cedex, France.|Chimie Paristech, Paris, F-75231, cedex, France.
authors: Eliott
authors: E
authors: Teston
authors: Laboratoire de Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), UMR 7244 CNRS, Université Paris, Bobigny, 93017, France.
authors: Yoann
authors: Y
authors: Lalatonne
authors: Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS, Université Paris Diderot, Paris, 75205, cedex, France.
authors: Dan
authors: D
authors: Elgrabli
authors: Laboratoire de Recherche en Imagerie, EA 4062, Inserm U 970 ou 494, Equipe 2, PARCC, Université Paris Descartes, Hôpital Européen George Pompidou, Paris, 75015, France.
authors: Gwennhael
authors: G
authors: Autret
authors: Laboratoire de Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), UMR 7244 CNRS, Université Paris, Bobigny, 93017, France.
authors: Laurence
authors: L
authors: Motte
authors: Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS, Université Paris Diderot, Paris, 75205, cedex, France.
authors: Florence
authors: F
authors: Gazeau
authors: Unité des Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, F-75270, cedex, France.|Chimie Paristech, Paris, F-75231, cedex, France.
authors: Daniel
authors: D
authors: Scherman
authors: Laboratoire de Recherche en Imagerie, EA 4062, Inserm U 970 ou 494, Equipe 2, PARCC, Université Paris Descartes, Hôpital Européen George Pompidou, Paris, 75015, France.
authors: Olivier
authors: O
authors: Clément
authors: Unité des Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, F-75270, cedex, France.|Chimie Paristech, Paris, F-75231, cedex, France.
authors: Cyrille
authors: C
authors: Richard
authors: Unité des Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, F-75270, cedex, France.|Chimie Paristech, Paris, F-75231, cedex, France.
authors: Thomas
authors: T
authors: Maldiney
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D015195:Drug Design; D008163:Luminescent Measurements / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods*; D009928:Organ Specificity; D010316:Particle Size; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles
keywords: hybrid materials; multimodality; nanoparticles; optical and magnetic resonance imaging; persistent luminescence