title: Epithelial ovarian cancers and endometriosis.
abstract: OBJECTIVE
  To determine the prevalence of endometriosis in epithelial ovarian cancers (EOC) and the association among their histological subtypes and with endometrial carcinoma.
  
  
  METHODS
  An observational cohort study performed in 192 patients operated on for EOC, 30 women with atypical endometriosis and 17 with p53 positive endometriosis. Data on associated endometriosis and endometrial carcinomas, histological subtypes, tumor stage, clinical and pathological characteristics and survival were analyzed.
  
  
  RESULTS
  Twenty cases of EOC (10.4%) had also endometriosis (12.7 in borderline and 9.3% in invasive cases), being a synchronous finding in most cases. Endometriosis associated with serous or mucinous EOC was observed in 2.2 and 2.7% of cases, respectively. However, this association was observed in 50 of endometrioid and 23% of clear cell EOC. Age, parity and tumor stage were lower in endometriosis-associated EOC patients; and all associated cases were type I (Kurman and Shih's classification) and showed better results in survival rate. Endometrial carcinoma was more frequently associated with endometrioid EOC (25%).
  
  
  CONCLUSIONS
  There is a significant association between endometriosis, including atypical forms, and endometrioid and clear cell carcinomas, but not with other EOC histotypes. The presence of endometriosis in EOC suggests a better prognosis and an intermediate stage within the progression endometriosis-carcinoma.
authors: Department of Obstetrics and Gynecology, San Juan University Hospital, Alicante, Spain.
authors: Pedro
authors: P
authors: Acién
authors: Irene
authors: I
authors: Velasco
authors: Maribel
authors: M
authors: Acién
authors: Cecilia
authors: C
authors: Capello
authors: Pilar
authors: P
authors: Vela
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000453:epidemiology*; D000077216:Carcinoma, Ovarian Epithelial; D015331:Cohort Studies; D015897:Comorbidity; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology*; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D055815:Young Adult