title: NOSH aspirin may have a protective role in Alzheimer's disease.
abstract: Evidence indicates that inflammation, oxidative stress, and the disruption of normal conformation of proteins might be directly linked to Alzheimer's disease (AD). The present study was undertaken using literature data to find a possible drug to address the multiple disorders involved in AD-associated Aβ accumulation and plaque formation. We consider NOSH-aspirin a drug of choice for reducing the inflammatory areas in the brain (aspirin moiety), removing the noxious heavy metals from plaques (hydrogen sulfide), and increasing the oxygen supply to neurons since nitrogen oxide is a potent vasodilator and an anti-inflammatory agent. Several confirmatory data in literature and possible mechanisms for cellular defence as well as novel therapeutical pathways are discussed.
authors: Faculty of Chemistry, Al. I. Cuza University of Iasi, 11 Carol I, Iasi 700506, Romania.
authors: Gabi
authors: G
authors: Drochioiu
authors: Faculty of Chemistry, Al. I. Cuza University of Iasi, 11 Carol I, Iasi 700506, Romania.
authors: Lucia
authors: L
authors: Tudorachi
authors: Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, 41A Grigore Ghica Voda Alee, Iasi 700487, Romania. Electronic address: manuelam@icmpp.ro.
authors: Manuela
authors: M
authors: Murariu
mesh_terms: D000544:Alzheimer Disease / Q000517:prevention & control*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004220:Disulfides / Q000627:therapeutic use*; D004660:Encephalitis / Q000188:drug therapy*; D006801:Humans; D008954:Models, Biological; D009566:Nitrates / Q000627:therapeutic use*
chemical_list: C571898:4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl 2-((4-(nitrooxy)butanoyl)oxy)benzoate; D004220:Disulfides; D009566:Nitrates; D001241:Aspirin