title: Rotifers as experimental tools for investigating aging.
abstract: Comparative biogerontology has much to contribute to the study of aging. A broad range of aging rates has evolved to meet environmental challenges, and understanding these adaptations can produce valuable insights into aging. The supra Phylum Lophotrochozoa is particularly understudied and has several groups that have intriguing patterns of aging. Members of the lophotrochozoan phylum Rotifera are particularly useful for aging studies because cohort life tables can be conducted with them easily, and biochemical and genomic tools are available for examining aging mechanisms. This paper reviews a variety of caloric restriction regimens, small molecule inhibitors, and dietary supplements that extend rotifer lifespan, as well as important interactions between caloric restriction and genotype, antioxidant supplements, and TOR and JNK pathways, and the use of RNAi to identify key genes involved in modulating the aging response. Examples of how rapamycin and JNK inhibitor exposure keeps mortality rates low during the reproductive phase of the life cycle are presented, and the ease of conducting life table experiments to screen natural products from red algae for life extending effects is illustrated. Finally, experimental evolution to produce longer-lived rotifer individuals is demonstrated, and future directions to determine the genetic basis of aging are discussed.
authors: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, 30332-0230, USA.
authors: Terry W
authors: TW
authors: Snell
authors: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, 30332-0230, USA.
authors: Rachel K
authors: RK
authors: Johnston
authors: Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA.
authors: Kristin E
authors: KE
authors: Gribble
authors: Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA.
authors: David B
authors: DB
authors: Mark Welch
keywords: JNK; TOR; aging; antioxidants; caloric restriction; comparative biogerontology; evolution
references: Nature. 2012 Dec 6;492(7427):S10-1
references: 23222666
references: Exp Gerontol. 2014 Apr;52:55-69
references: 24486130
references: Pharmacol Rev. 2012 Jan;64(1):88-101
references: 22090473
references: Exp Gerontol. 2013 Dec;48(12):1420-7
references: 24120568
references: Exp Gerontol. 2014 Mar;51:28-37
references: 24384399
references: Aging Cell. 2007 Feb;6(1):1-13
references: 17156084
references: . 2014 Mar;99(1-2):117-124
references: 24795527
references: J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):349-58
references: 22904096
references: . 2014 Mar;99(1-2):84-95
references: 24791148
references: J Exp Biol. 2011 Jun 1;214(Pt 11):1902-10
references: 21562178
references: J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):192-4
references: 19181713
references: Aging Cell. 2014 Aug;13(4):623-30
references: 24661622
references: J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):295-7
references: 21059837
references: Nat Chem Biol. 2008 Nov;4(11):682-90
references: 18936753
references: J Comp Pathol. 2010 Jan;142 Suppl 1:S10-21
references: 19962715
references: Biogerontology. 2012 Jun;13(3):261-75
references: 22270335