title: Impact of enteral nutrition on energy metabolism in patients with Crohn's disease.
abstract: OBJECTIVE
  To investigate the impact of enteral nutrition (EN) on the body composition and metabolism in patients with Crohn's disease (CD).
  
  
  METHODS
  Sixty-one patients diagnosed with CD were enrolled in this study. They were given only EN (enteral nutritional suspension, TPF, non-elemental diet) support for 4 wk, without any treatment with corticosteroids, immunosuppressive drugs, infliximab or by surgical operation. Body composition statistics such as weight, body mass index, skeletal muscle mass (SMM), fat mass, protein mass and inflammation indexes such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and CD activity index (CDAI) were recorded before and after EN support.
  
  
  RESULTS
  The 61 patients were divided into three groups according to CDAI before and after EN support: A (active phase into remission via EN, n=21), B (remained in active phase before and after EN, n=19) and C (in remission before and after EN, n=21). Patients in group A had a significant increase in SMM (22.11±4.77 kg vs 23.23±4.49 kg, P=0.044), protein mass (8.01±1.57 kg vs 8.44±1.45 kg, P=0.019) and decrease in resting energy expenditure (REE) per kilogram (27.42±5.01 kcal/kg per day vs 22.62±5.45 kcal/kg per day, P<0.05). There was no significant difference between predicted and measured REE in active CD patients according to the Harris-Benedict equation. There was no linear correlation between the measured REE and CRP, ESR or CDAI in active CD patients.
  
  
  CONCLUSIONS
  EN could decrease the hypermetabolism in active CD patients by reducing the inflammatory response.
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Jie
authors: J
authors: Zhao
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Jian-Ning
authors: JN
authors: Dong
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Jian-Feng
authors: JF
authors: Gong
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Hong-Gang
authors: HG
authors: Wang
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Yi
authors: Y
authors: Li
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Liang
authors: L
authors: Zhang
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Lu-Gen
authors: LG
authors: Zuo
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Yun
authors: Y
authors: Feng
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Li-Li
authors: LL
authors: Gu
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Ning
authors: N
authors: Li
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Jie-Shou
authors: JS
authors: Li
authors: Jie Zhao, Jian-Ning Dong, Jian-Feng Gong, Hong-Gang Wang, Yi Li, Liang Zhang, Lu-Gen Zuo, Yun Feng, Li-Li Gu, Ning Li, Jie-Shou Li, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Wei-Ming
authors: WM
authors: Zhu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002681:China; D003424:Crohn Disease / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: Body composition; Crohn’s disease; Enteral nutrition; Metabolism
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