title: Invasive pulmonary aspergillosis - case report and review of literature.
abstract: Invasive pulmonary aspergillosis (IPA) is a severe fungal infection with a high mortality rate. The incidence of IPA is on the rise due to an increase in the number of patients undergoing transplants and receiving chemotherapy and immunosuppressive therapy. Diagnosis is challenging due to the non-specific nature of symptoms. Voriconazole is the mainstay of therapy. We present a case of an elderly woman presenting with acute bronchitis and asthma exacerbation, who succumbed to overwhelming IPA. It is uncommon for IPA to develop in patients on short-term steroid therapy for asthma exacerbation. The possibility of aspergillosis in immunocompetent patients should be considered in those on systemic steroids and deteriorating pulmonary functions.
authors: Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, New Rochelle, NY, USA; anaaraay@montefiore.org.
authors: Ashutossh
authors: A
authors: Naaraayan
authors: Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, New Rochelle, NY, USA.
authors: Ronak
authors: R
authors: Kavian
authors: Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, New Rochelle, NY, USA.
authors: Jeffrey
authors: J
authors: Lederman
authors: Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, New Rochelle, NY, USA.
authors: Prasanta
authors: P
authors: Basak
authors: Department of Internal Medicine, Montefiore New Rochelle Hospital, Albert Einstein College of Medicine, New Rochelle, NY, USA.
authors: Stephen
authors: S
authors: Jesmajian
keywords: aspergillus; asthma exacerbation; ground glass opacities; steroids; vascular invasion
references: Leuk Lymphoma. 2009 May;50(5):703-15
references: 19337880
references: Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S620-9
references: 3317755
references: Clin Infect Dis. 2008 Jun 15;46(12):1813-21
references: 18462102
references: Am J Med. 1996 Feb;100(2):171-8
references: 8629651
references: J Infect. 2012 Nov;65(5):453-64
references: 22898389
references: Thorax. 2015 Mar;70(3):270-7
references: 25354514
references: Eur Respir J. 2007 Oct;30(4):782-800
references: 17906086
references: Blood. 2003 Aug 1;102(3):827-33
references: 12689933
references: QJM. 2007 Jun;100(6):317-34
references: 17525130
references: Clin Infect Dis. 2000 Oct;31(4):859-68
references: 11049762
references: J Clin Microbiol. 2014 Jun;52(6):2039-45
references: 24671798
references: Medicine (Baltimore). 2000 Jul;79(4):250-60
references: 10941354
references: Clin Infect Dis. 2009 Nov 15;49(10):1486-91
references: 19827955
references: Microbiology. 1994 Sep;140 ( Pt 9):2475-9
references: 7952197
references: Chest. 1983 Jan;83(1):138-9
references: 6848318
references: Eur J Clin Microbiol Infect Dis. 2004 Jun;23(6):491-4
references: 15141337
references: Ann Intern Med. 1996 Mar 15;124(6):585-99
references: 8597323
references: Blood. 2004 Mar 15;103(6):2143-9
references: 14630829
references: N Engl J Med. 2002 Aug 8;347(6):408-15
references: 12167683
references: Mycoses. 2008 Mar;51(2):117-22
references: 18254747
references: Am J Med. 1986 Aug;81(2):249-54
references: 3090879
references: Tuberc Respir Dis (Seoul). 2012 May;72(5):448-51
references: 23101010
references: Clin Microbiol Infect. 2003 Dec;9(12):1224-7
references: 14686988