title: Comparison of voice outcomes after trial and long-term vocal fold augmentation in vocal fold atrophy.
abstract: OBJECTIVE
  To compare voice outcomes after vocal fold augmentation using a trial (temporary) vocal fold injection (VFI) versus long-term augmentation in patients diagnosed with vocal fold atrophy.
  
  
  METHODS
  Retrospective, single-blinded study.
  
  
  METHODS
  Nineteen patients diagnosed with vocal fold atrophy underwent trial VFI and subsequent long-term augmentation. Voice Handicap Index-10, acoustic, and aerodynamic measures were analyzed following trial and long-term augmentation procedures.
  
  
  RESULTS
  Forty-two percent (8/19) of patients had a good response to trial VFI (P < .0001); 58% (11/19) had a poor response to trial VFI (P = .95). Of the patients with good response to trial VFI, 75% (6/8) also had good response to long-term augmentation (P = .006), but 25% (2/8) reported a poor response to long-term treatment. Of the patients who had a poor response to trial VFI, 55% (6/11) also had a poor response to long-term treatment, but 45% (5/11) of patients reported good response after long-term augmentation.
  
  
  CONCLUSIONS
  This is the first study to provide comparative voice outcomes using both trial VFI and long-term augmentation for vocal fold atrophy. Additional critical evaluation of the value of trial VFI for vocal fold atrophy patients is suggested.
authors: Department of Otolaryngology, University of Pittsburgh Voice Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
authors: VyVy N
authors: VN
authors: Young
authors: Jackie
authors: J
authors: Gartner-Schmidt
authors: Clark A
authors: CA
authors: Rosen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D015552:Injections, Intralesional; D007818:Laryngeal Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016037:Single-Blind Method; D013997:Time Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D014832:Voice Disorders / Q000209:etiology / Q000628:therapy; D014833:Voice Quality
chemical_list: D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium
keywords: Trial vocal fold injection; vocal fold atrophy; voice outcome