title: Dasatinib-induced pulmonary hypertension in acute lymphoblastic leukemia: case report.
abstract: Pulmonary hypertension (PHT) is a pathological condition determined as an increase in mean pulmonary arterial pressure ≥25 mmHg. Pulmonary arterial hypertension (PAH) is precapillary PHT and a life-threatening disease group which consists of different etiologies with the same pathological and clinical findings, and which is characterized by elevated pulmonary vascular resistance. Dasatinib is a dual Src/Abl kinase inhibitor associated with higher affinity for BCR/ABL kinase than imatinib, and is used in the treatment of chronic myelocytic leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia (ALL). We describe a case with ALL, in whom dasatinib treatment induced PAH, and who recovered with bosentan treatment.
authors: Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey. gtacoy@yahoo.com.
authors: Gülten
authors: G
authors: Taçoy
authors: Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Atiye
authors: A
authors: Çengel
authors: Department of Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Zübeyde Nur
authors: ZN
authors: Özkurt
authors: Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors: Sedat
authors: S
authors: Türkoğlu
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000069439:Dasatinib; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; D013844:Thiazoles; D000069439:Dasatinib