title: The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury.
abstract: Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0-4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt and ERK1/2 pathways. Further studies revealed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China.
authors: Leilei
authors: L
authors: Gong
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China.
authors: Yun
authors: Y
authors: Zhu
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China.
authors: Xi
authors: X
authors: Xu
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China.
authors: Huaiqin
authors: H
authors: Li
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China.
authors: Weimin
authors: W
authors: Guo
authors: Key Laboratory of People's Liberation Army, Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China.
authors: Qin
authors: Q
authors: Zhao
authors: Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong, Jiangsu Province, China ; School of Life Sciences, Nantong University, Nantong, Jiangsu Province, China.
authors: Dengbing
authors: D
authors: Yao
keywords: Akt; Claudin 14; ERK1/2; NSFC grant; Schwann cell; Signal pathways; Wallerian degeneration; c-Jun; nerve regeneration; neural regeneration; peripheral nerve injury; rat; sciatic nerve injury
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