title: [Metabonomic analysis of the serum from rat model with abnormal balgam syndrome of Uyghur medicine].
abstract: OBJECTIVE
  To investigate correlation between the change in metabolic components of serum and the abnormal balgam syndrome by using a rat model of abnormal balgam syndrome.
  
  
  METHODS
  Male Wistar rats were randomly divided into a control group and a test group. According to Uyghur medicine theory, the test group of rats were given wet cold diet (seeds of spinach and parsley, 24 hours) in a cold (6 °C) and humid (85%-95%, 10 hours) environment for 40 days to establish the rat model of abnormal balgam syndrome. 1H MR based metabonomic analysis of serum was performed. Data was analyzed using Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) software.
  
  
  RESULTS
  Compared with the control group, the serum components including glutamate, phenylalanine, tyrosine, citric acid, β-hydrocxy butyrate, acetoacetate, pyruvic acid and creatine were decreased, while the glucose, lactic acid, low density lipoprotein and very low density lipoprotein were increased in the test group (P<0.05).
  
  
  CONCLUSIONS
  The low energy production and consumption in the rat model of abnormal balgam syndrome suggests that the dysfunctional metabolisms of three major nutrients might be the molecular basis for the abnormal balgam syndrome.
authors: Basic Medical School, Xinjiang Medical University, Urumqi 830011, China.
authors: Gulinisha
authors: G
authors: Mosha
authors: Ajiguli
authors: A
authors: Nurmaimaiti
authors: Jingping
authors: J
authors: Zhang
authors: Mairipaiti
authors: M
authors: Abudula
authors: Jingjing
authors: J
authors: Huang
authors: Kurexi
authors: K
authors: Yunusi
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002264:Carboxylic Acids / Q000097:blood*; D003401:Creatine / Q000097:blood; D004195:Disease Models, Animal; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008516:Medicine, Chinese Traditional; D055432:Metabolomics; D051381:Rats; D017208:Rats, Wistar; D013577:Syndrome
chemical_list: D001786:Blood Glucose; D002264:Carboxylic Acids; D008077:Lipoproteins, LDL; D003401:Creatine