title: Computer-aided quantification of interstitial lung disease from high resolution computed tomography images in systemic sclerosis: correlation with visual reader-based score and physiologic tests.
abstract: OBJECTIVE
  To evaluate the performance of a computerized-aided method (CaM) for quantification of interstitial lung disease (ILD) in patients with systemic sclerosis and to determine its correlation with the conventional visual reader-based score (CoVR) and the pulmonary function tests (PFTs).
  
  
  METHODS
  Seventy-nine patients were enrolled. All patients underwent chest high resolution computed tomography (HRCT) scored by two radiologists adopting the CoVR. All HRCT images were then analysed by a CaM using a DICOM software. The relationships among the lung segmentation analysis, the readers, and the PFTs results were calculated using linear regression analysis and Pearson's correlation. Receiver operating curve analysis was performed for determination of CaM extent threshold.
  
  
  RESULTS
  A strong correlation between CaM and CoVR was observed (P < 0.0001). The CaM showed a significant negative correlation with forced vital capacity (FVC) (P < 0.0001) and the single breath carbon monoxide diffusing capacity of the lung (DLco) (P < 0.0001). A CaM optimal extent threshold of 20% represented the best compromise between sensitivity (75.6%) and specificity (97.4%).
  
  
  CONCLUSIONS
  CaM quantification of SSc-ILD can be useful in the assessment of extent of lung disease and may provide reliable tool in daily clinical practice and clinical trials.
authors: Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy.
authors: Fausto
authors: F
authors: Salaffi
authors: Department of Radiology, Polytechnic University of the Marche, Ancona, Italy.
authors: Marina
authors: M
authors: Carotti
authors: Division of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors: Silvia
authors: S
authors: Bosello
authors: Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy.
authors: Alessandro
authors: 0000-0002-3224-1760
authors: A
authors: Ciapetti
authors: Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy.
authors: Marwin
authors: 0000-0002-7995-1110
authors: M
authors: Gutierrez
authors: Department of Radiology, Polytechnic University of the Marche, Ancona, Italy.
authors: Elisabetta
authors: E
authors: Bichisecchi
authors: Department of Radiology, Polytechnic University of the Marche, Ancona, Italy.
authors: Gianmarco
authors: G
authors: Giuseppetti
authors: Division of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors: Gianfranco
authors: G
authors: Ferraccioli
mesh_terms: D005240:Feasibility Studies; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*
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