title: Human tissue models for a human disease: what are the barriers?
abstract: Asthma represents an area of significant unmet medical need, with few new drugs making it to the clinic in the past 50 years. Much asthma research is currently carried out in non-human models. However, as asthma is a uniquely human condition, it is difficult to translate findings from these models to efficacious therapies. Based on the results of a survey of the UK asthma research community carried out jointly between the NC3Rs, Asthma UK, the UK Respiratory Research Collaborative and the Human Tissue Authority, we propose that more emphasis be placed on the use of human tissue studies to provide more relevant models that better translate to the clinic and which reduce the reliance of the asthma community on less predictive animal models.
authors: National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, UK.
authors: Joanna
authors: J
authors: Edwards
authors: Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK.
authors: Maria
authors: M
authors: Belvisi
authors: Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
authors: Sven-Erik
authors: SE
authors: Dahlen
authors: Faculty of Medicine, University of Southampton, Southampton, UK.
authors: Stephen
authors: S
authors: Holgate
authors: National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, UK.
authors: Anthony
authors: A
authors: Holmes
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001291:Attitude of Health Personnel; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D011364:Professional Practice / Q000706:statistics & numerical data; D012108:Research Personnel / Q000523:psychology
chemical_list: D018927:Anti-Asthmatic Agents
keywords: Asthma; Asthma Mechanisms; Asthma Pharmacology
references: Drug Discov Today. 2011 Aug;16(15-16):659-70
references: 21723955
references: Allergy. 2007 Feb;62(2):126-33
references: 17298420
references: J Asthma. 2009 Apr;46(3):234-7
references: 19373629
references: Prim Care Respir J. 2006 Dec;15(6):326-31
references: 17092772
references: Nat Med. 2012 May;18(5):716-25
references: 22561835