title: Hemodynamic, ventilatory and gasometric evaluation of an experimental bronchopleural fistula.
abstract: OBJECTIVE
  To investigate the hemodynamic and ventilatory changes associated with the creation of an experimental bronchopleural fistula (BPF) treated by mechanical ventilation and thoracic drainage with or without a water seal.
  
  
  METHODS
  Six large white pigs weighing 25 kg each which, after general anesthesia, underwent endotracheal intubation (6mm), and mechanically ventilation. Through a left thoracotomy, a resection of the lingula was performed in order to create a BPF with an output exceeding 50% of the inspired volume. The chest cavity was closed and drained into the water sealed system for initial observation of the high output BPF.
  
  
  RESULTS
  Significant reduction in BPF output and PaCO2 was related after insertion of a water-sealed thoracic drain, p< 0.05.
  
  
  CONCLUSIONS
  Insertion of a water-sealed thoracic drain resulted in reduction in bronchopleural fistula output and better CO2 clearance without any drop in cardiac output or significant changes in mean arterial pressure.
authors: Faculty of Medical Sciences, State University of Campinas, Brazil.
authors: Douglas Guimaraes de
authors: DG
authors: Oliveira
authors: Department of Physical Therapy, University of Jaguariuna, Brazil.
authors: Maria Gabriela Cavicchia
authors: MG
authors: Toneloto
authors: Department of Surgery, Medical School, UNICAMP, Campinas, SP, Brazil.
authors: Marcos Mello
authors: MM
authors: Moreira
authors: Department of Surgery, Medical School, UNICAMP, Campinas, SP, Brazil.
authors: Joaquim Murray
authors: JM
authors: Bustorff-Silva
authors: Department of Statistics, UNICAMP, Campinas, SP, Brazil.
authors: Gabriel Franco de
authors: GF
authors: Souza
authors: Department of Surgery, Medical School, UNICAMP, Campinas, SP, Brazil.
authors: Luiz Claudio
authors: LC
authors: Martins
authors: Department of Nursing, Federal University of Alfenas, Campinas, SP, Brazil.
authors: Carolina
authors: C
authors: Kosour
authors: Department of Surgery, Medical School, UNICAMP, Campinas, SP, Brazil.
authors: Desanka
authors: D
authors: Dragosavac
authors: Department of Surgery, Medical School, UNICAMP, Campinas, SP, Brazil.
authors: Antonio Luis Eiras
authors: AL
authors: Falcão
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001983:Bronchial Fistula / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D002302:Cardiac Output / Q000502:physiology; D004195:Disease Models, Animal; D004322:Drainage / Q000379:methods; D006439:Hemodynamics / Q000502:physiology*; D010995:Pleural Diseases / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D012123:Pulmonary Ventilation / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D012121:Respiration, Artificial / Q000379:methods; D012129:Respiratory Function Tests; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome