title: Effects of low-dose G-CSF formulation on hematology in healthy horses after long-distance transportation.
abstract: The present study evaluated the effects of single-dose filgrastim on hematology in 16 healthy horses after long-distance transportation. Horses were assigned to receive filgrastim (0.23 µg/kg, SC, once; G-CSF group; n=8) or saline (0.9% NaCl) solution (0.3 ml, SC, once; control group; n=8) ≤ 1 hr before transportation. Horses were transported 2,530 km using commercial vans over the course of approximately 44 hr. Clinical examinations and hematologic analyses were performed on all horses before and after transportation. Because the post-transportation white blood cell counts and bacillary neutrophil to segmented neutrophil ratio were significantly higher in the G-CSF group, filgrastim may have promoted the mobilization of neutrophils from marrow. Filgrastim deserves a further study for efficacy in preventing horse shipping fever.
authors: Miyazaki Yearling Training Farm, Japan Racing Association, 2347, Oharu, Hanagashima-cho, Miyazaki-shi, Miyazaki 880-0036, Japan.
authors: Yoshiro
authors: Y
authors: Endo
authors: Seiji
authors: S
authors: Hobo
authors: Kenji
authors: K
authors: Korosue
authors: Kenji
authors: K
authors: Ootsuka
authors: Akira
authors: A
authors: Kitauchi
authors: Risa
authors: R
authors: Kikkawa
authors: Yuichi
authors: Y
authors: Hidaka
authors: Mitsuyoshi
authors: M
authors: Hagio
authors: Nao
authors: N
authors: Tsuzuki
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D000069585:Filgrastim / Q000494:pharmacology*; D006736:Horses / Q000097:blood*; D008297:Male; D013997:Time Factors; D014186:Transportation
chemical_list: D000069585:Filgrastim
references: J Vet Diagn Invest. 2012 Jan;24(1):219-26
references: 22362958
references: J Comp Pathol. 1995 Jul;113(1):29-43
references: 7490335
references: Eur J Cancer. 2006 Oct;42(15):2433-53
references: 16750358
references: J Equine Sci. 2014;25(4):79-81
references: 25558181
references: J Vet Med Sci. 2001 Dec;63(12):1263-9
references: 11789602
references: Medicina (Kaunas). 2014;50(3):144-9
references: 25323541
references: J Vet Med Sci. 2015 Jan;77(1):75-9
references: 25720808
references: Am J Vet Res. 2012 Jul;73(7):968-72
references: 22738047
references: J Vet Med Sci. 2003 Jul;65(7):787-92
references: 12939505
references: J Vet Med Sci. 1996 Jun;58(6):537-41
references: 8811622