title: Various levels and forms of dietary α-lipoic acid in broiler chickens: Impact on blood biochemistry, stress response, liver enzymes, and antibody titers.
abstract: The present experiment was conducted to evaluate the impact of various levels and forms of α-lipoic acid (ALA) on blood biochemistry, immune and stress response, and antibody titers in broiler chickens. The four levels (7.5, 15, 75, and 150 ppm) and 2 sources (powder, P-ALA and encapsulated, E-ALA) of ALA along with negative (C-) and positive control (C+; contains antibiotics) diets consisted of 10 dietary treatments, and these treatments were allocated to 1,200 1-d-old chicks and were replicated 12 times with 10 birds per replicate. Among the blood biochemistry parameters, creatinine levels were almost 3 times lower in E-ALA-supplemented diets compared to the C- diet (0.09 vs. 0.25 mg/dL; P<0.0001). Neither level nor source of ALA affected blood urea nitrogen (BUN), total protein (TP), albumin, globulin, or albumin to globulin ratio (AGR). The supplemented diets decreased serum levels of the liver enzymes aspartate-aminotransferase (AST; P<0.006) and alanine-aminotransferase (ALT; P<0.0003). The Newcastle disease virus (NDV) antibody response in supplemented groups was poor at day zero (P<0.0001) but increased by d 14 (P<0.03). Birds did not respond to infectious bronchitis virus (IBV) vaccination at any observed stage (P>0.05). The concentration of cortisol was reduced in chickens fed ALA-supplemented diets as compared to the C- diet (P<0.001). Results suggest that ALA-supplemented diets ameliorated blood biochemistry profiles and immune responses and reduced stress in broiler chickens. The encapsulated form of ALA was more effective than the powder form.
authors: National Institute of Animal Science, RDA, Suwon 441-706, Republic of Korea.
authors: D W
authors: DW
authors: Kim
authors: AgroVisions, 19 D-Ground, Faisalabad 38800, Pakistan Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea haroonuaf@gmail.com.
authors: M M H
authors: MM
authors: Mushtaq
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: R
authors: R
authors: Parvin
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: H K
authors: HK
authors: Kang
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: J H
authors: JH
authors: Kim
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: J C
authors: JC
authors: Na
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: J
authors: J
authors: Hwangbo
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: J D
authors: JD
authors: Kim
authors: National Institute of Animal Science, RDA, Suwon 441-706, Republic of Korea.
authors: C B
authors: CB
authors: Yang
authors: BSC Bio, Daejeon 305-150, Republic of Korea.
authors: B J
authors: BJ
authors: Park
authors: Poultry Science Division, National Institute of Animal Science, RDA, Seonghwan, Cheonan 301-800, Republic of Korea.
authors: H C
authors: HC
authors: Choi
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000906:Antibodies / Q000097:blood*; D002645:Chickens / Q000097:blood* / Q000502:physiology; D004032:Diet / Q000662:veterinary*; D008099:Liver / Q000201:enzymology*; D008297:Male; D013312:Stress, Physiological / Q000187:drug effects*; D008063:Thioctic Acid / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000906:Antibodies; D008063:Thioctic Acid
keywords: blood biochemistry; broiler chicken; immune and stress response; lipoic acid