title: Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord.
abstract: Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600 μm(2)) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small (<600 μm(2)) sympathetic neurons (TRPV1, 22.0%; TRPV2, 13.6%). The present study also demonstrated that 10.0% of sympathetic neurons in the stellate ganglion had pericellular TRPV2-IR nerve fibers. Fourteen percent of large neurons and 7.8% of small neurons were surrounded by TRPV2-IR nerve fibers. TRPV2-immunoreactivity was also detected in about 40% of neuronal cell bodies with pericellular TRPV2-IR nerve fibers. In the lateral horn of the human thoracic spinal cord, TRPV2-immunoreactivity was expressed by some neurons and many varicose fibers surrounding TRPV2-immunonegative neurons. TRPV2-IR pericellular fibers in the stellate ganglion may originate from the lateral horn of the spinal cord. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Souichi
authors: S
authors: Kokubun
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Tadasu
authors: T
authors: Sato
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Chikara
authors: C
authors: Ogawa
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Kai
authors: K
authors: Kudo
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Koju
authors: K
authors: Goto
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Yuki
authors: Y
authors: Fujii
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors: Yoshinaka
authors: Y
authors: Shimizu
authors: Divisions of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan. Electronic address: hiroichi@anat.dent.tohoku.ac.jp.
authors: Hiroyuki
authors: H
authors: Ichikawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009928:Organ Specificity; D013116:Spinal Cord / Q000378:metabolism*; D013233:Stellate Ganglion / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; C400769:TRPV2 protein, human
keywords: Human; Immunohistochemistry; Spinal cord; Stellate ganglion; TRPV1; TRPV2