title: Unmasking Language Lateralization in Human Brain Intrinsic Activity.
abstract: Lateralization of function is a fundamental feature of the human brain as exemplified by the left hemisphere dominance of language. Despite the prominence of lateralization in the lesion, split-brain and task-based fMRI literature, surprisingly little asymmetry has been revealed in the increasingly popular functional imaging studies of spontaneous fluctuations in the fMRI BOLD signal (so-called resting-state fMRI). Here, we show the global signal, an often discarded component of the BOLD signal in resting-state studies, reveals a leftward asymmetry that maps onto regions preferential for semantic processing in left frontal and temporal cortex and the right cerebellum and a rightward asymmetry that maps onto putative attention-related regions in right frontal, temporoparietal, and parietal cortex. Hemispheric asymmetries in the global signal resulted from amplitude modulation of the spontaneous fluctuations. To confirm these findings obtained from normal, healthy, right-handed subjects in the resting-state, we had them perform 2 semantic processing tasks: synonym and numerical magnitude judgment and sentence comprehension. In addition to establishing a new technique for studying lateralization through functional imaging of the resting-state, our findings shed new light on the physiology of the global brain signal.
authors: Department of Radiology, Washington University, Saint Louis, MO 63110, USA.
authors: Mark
authors: M
authors: McAvoy
authors: Department of Radiology, Washington University, Saint Louis, MO 63110, USA.
authors: Anish
authors: A
authors: Mitra
authors: Department of Radiology, Washington University, Saint Louis, MO 63110, USA Department of Neurology, Washington University, Saint Louis, MO 63110, USA.
authors: Rebecca S
authors: RS
authors: Coalson
authors: School of Psychology, Bangor University, Bangor, UK.
authors: Giovanni
authors: G
authors: d'Avossa
authors: School of Psychology, Bangor University, Bangor, UK.
authors: James L
authors: JL
authors: Keidel
authors: Department of Radiology, Washington University, Saint Louis, MO 63110, USA Department of Neurology, Washington University, Saint Louis, MO 63110, USA Department of Anatomy and Neurobiology, Washington University, Saint Louis, MO 63110, USA Department of Neurosurgery, Washington University, Saint Louis, MO 63110, USA Department of Psychology, Washington University, Saint Louis, MO 63110, USA Department of Biomedical Engineering, Washington University, Saint Louis, MO 63110, USA.
authors: Steven E
authors: SE
authors: Petersen
authors: Department of Radiology, Washington University, Saint Louis, MO 63110, USA Department of Neurology, Washington University, Saint Louis, MO 63110, USA Department of Anatomy and Neurobiology, Washington University, Saint Louis, MO 63110, USA Department of Biomedical Engineering, Washington University, Saint Louis, MO 63110, USA.
authors: Marcus E
authors: ME
authors: Raichle
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D032882:Comprehension / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007600:Judgment / Q000502:physiology; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012660:Semantics; D055815:Young Adult
keywords: attention network; global signal; hemispheric asymmetry; resting-state; semantic network
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