title: Longitudinal Relationship Among Physical Fitness, Walking-Related Physical Activity, and Fatigue in Children With Cerebral Palsy.
abstract: BACKGROUND
  A vicious circle of decreased physical fitness, early fatigue, and low physical activity levels (PAL) is thought to affect children with cerebral palsy (CP). However, the relationship of changes in physical fitness to changes in PAL and fatigue is unclear.
  
  
  OBJECTIVE
  The objective of this study was to investigate the associations among changes in physical fitness, walking-related PAL, and fatigue in children with CP.
  
  
  METHODS
  This study was a secondary analysis of a randomized controlled trial with measurements at baseline, 6 months (after the intervention period), and 12 months.
  
  
  METHODS
  Twenty-four children with bilateral spastic CP and 22 with unilateral spastic CP, aged 7 to 13 years, all walking, participated in this study. Physical fitness was measured by aerobic capacity, anaerobic threshold, anaerobic capacity, and isometric and functional muscle strength. Walking-related PAL was measured using an ankle-worn activity monitor for 1 week. Fatigue was determined with the Pediatric Quality of Life (PedsQL) Multidimensional Fatigue Scale. Longitudinal associations were analyzed by random coefficient regression analysis.
  
  
  RESULTS
  In children with bilateral CP, all fitness parameters showed a positive, significant association with walking-related PAL, whereas no associations between physical fitness and walking-related PAL were seen in children with unilateral CP. No clinically relevant association between physical fitness and fatigue was found.
  
  
  CONCLUSIONS
  Although random coefficient regression analysis can be used to investigate longitudinal associations between parameters, a causal relationship cannot be determined. The actual direction of the association between physical fitness and walking-related PAL, therefore, remains inconclusive.
  
  
  CONCLUSIONS
  Children with bilateral spastic CP might benefit from improved physical fitness to increase their PAL or vice versa, although this is not the case in children with unilateral CP. There appears to be no relationship between physical fitness and self-reported fatigue in children with CP. Interventions aimed at improving PAL may be differently targeted in children with either bilateral or unilateral CP.
authors: A.C.J. Balemans, PhD, Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, and EMGO+ Institute for Health and Care Research, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, the Netherlands. a.balemans@vumc.nl.
authors: Astrid C J
authors: AC
authors: Balemans
authors: L. van Wely, PhD, Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, and EMGO+ Institute for Health and Care Research, VU University Medical Centre.
authors: Leontien
authors: L
authors: van Wely
authors: J.G. Becher, MD, PhD, Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, and EMGO+ Institute for Health and Care Research, VU University Medical Centre.
authors: Jules G
authors: JG
authors: Becher
authors: A.J. Dallmeijer, PhD, Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, and EMGO+ Institute for Health and Care Research, VU University Medical Centre.
authors: Annet J
authors: AJ
authors: Dallmeijer
mesh_terms: D000293:Adolescent; D002547:Cerebral Palsy / Q000150:complications / Q000503:physiopathology* / Q000534:rehabilitation; D002648:Child; D005081:Exercise Therapy; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D011788:Quality of Life; D016138:Walking / Q000502:physiology*