title: The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis.
abstract: Molecules that link innate and adaptive immunity and regulate immune response in health and disease are now the focus of many studies. This review discusses CD74 and its ligand macrophage migration inhibitory factor (MIF), and their central position in linking these two components of the immune response by controlling survival of macrophages and B cells.
authors: Richard
authors: R
authors: Bucala
authors: Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. Idit.shachar@weizmann.ac.il.
authors: Idit
authors: I
authors: Shachar
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D015703:Antigens, CD / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002470:Cell Survival / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology / Q000378:metabolism*; D012799:Sialyltransferases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
chemical_list: D015703:Antigens, CD; D008263:Macrophage Migration-Inhibitory Factors; D012799:Sialyltransferases; C093493:ST6GAL1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase