title: Ascorbic Acid may Exacerbate Aspirin-Induced Increase in Intestinal Permeability.
abstract: Ascorbic acid in combination with aspirin has been used to prevent aspirin-induced oxidative GI damage. We aimed to determine whether ascorbic acid reduces or prevents aspirin-induced changes in intestinal permeability over a 6-hr period using saccharidic probes mannitol and lactulose. The effects of administration of 600 mg aspirin alone, 500 mg ascorbic acid alone and simultaneous dosage of both agents were compared in a cross-over study in 28 healthy female volunteers. These effects were also compared with that of a placebo. The ability of ascorbic acid to mitigate the effects of aspirin when administered either half an hour before or after dosage with aspirin was also assessed in 19 healthy female volunteers. The excretion of lactulose over the 6-hr period was augmented after consumption of either aspirin or ascorbic acid compared with that after consumption of placebo. Dosage with ascorbic acid alone augmented the excretion of lactulose more than did aspirin alone. Simultaneous dosage with both agents augmented the excretion of lactulose in an additive manner. The timing of dosage with ascorbic acid in relation to that with aspirin had no significant effect on the excretion of the two sugars. These findings indicate that ascorbic acid does not prevent aspirin-induced increase in gut permeability rather that both agents augment it to a similar extent. The additive effect on simultaneous dosage with both agents in augmenting the absorption of lactulose suggests that each influences paracellular permeability by different pathways.
authors: Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
authors: Ivana R
authors: IR
authors: Sequeira
authors: Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
authors: Marlena C
authors: MC
authors: Kruger
authors: The New Zealand Institute for Plant and Food Research Limited, Palmerston North, New Zealand.
authors: Roger D
authors: RD
authors: Hurst
authors: Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
authors: Roger G
authors: RG
authors: Lentle
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects; D007792:Lactulose / Q000652:urine; D008353:Mannitol / Q000652:urine; D010539:Permeability / Q000187:drug effects; D019108:Tight Junctions / Q000187:drug effects; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008353:Mannitol; D007792:Lactulose; D001205:Ascorbic Acid; D001241:Aspirin