title: MicroRNAs as potential therapeutics for treating spinal cord injury.
abstract: MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.
authors: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China ; West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Hualin
authors: H
authors: Yan
authors: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Peiwei
authors: P
authors: Hong
authors: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Mei
authors: M
authors: Jiang
authors: West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors: Hedong
authors: H
authors: Li
keywords: antagomir; anti-miR; axonal regeneration; microRNAs; neural regeneration; reactive astrogliosis; reviews; spinal cord injury
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