title: Diversity in GABAergic signaling.
abstract: GABA(A) receptor-mediated synaptic transmission is responsible for inhibitory control of neural function in the brain. Recent progress has shown that GABA(A) receptors also provide a wide range of additional functions beyond simple inhibition. This diversity of functions is mediated by a large variety of different interneuron classes acting on a diverse population of receptor subtypes. Here, I will focus on an additional source of GABAergic signaling diversity, caused by the highly variable ion signaling mechanism of GABA(A) receptors. In concert with the other two sources of GABAergic heterogeneity, this variability in signaling allows for a wide array of GABAergic effects that are crucial for the development of the brain and its function.
authors: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: vogt.kaspar.fu@u.tsukuba.ac.jp.
authors: Kaspar
authors: K
authors: Vogt
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid
keywords: Chloride; Circadian; Depolarization; Development; GABA; GABA(A) receptor; Hyperpolarization; Imaging; Inhibition; KCC2; NKCC1; Neuron; Patch-clamp; Perforated patch; Subcellular