title: [HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis].
abstract: OBJECTIVE
  To analyze the HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis (PBC).
  
  
  METHODS
  Sequencing based typing-polymerase chain reaction (SBT-PCR) was used to investigate the HLA class I alleles of 146 PBC patients and 500 normal controls in northern China. The frequencies of alleles and haplotypes were calculated and compared for the two groups. The chi-square test and Fisher's exact test were used for statistical analyses.
  
  
  RESULTS
  There were 26, 51 and 21 alleles identified at the HLA-A, B and C loci respectively, and the frequencies of these alleles were not significantly different between the PBC and normal control groups.However, the frequencies of A *11:01-B*40:06 and A*02:01-B*l5:01 haplotypes were significantly higher in the PBC group than in the normal control group (7.53% vs. 1.40%, P<0.01, OR=5.38; 6.85% vs. 2.00%, P=0.003, OR=3.425).
  
  
  CONCLUSIONS
  This study established the role of HLA class I haplotypes in determining PBC susceptibility in a Chinese population.
authors: Clinical Research Center for Autoimmune Liver Disease, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors: Dantong
authors: D
authors: Zhao
authors: Huiyu
authors: H
authors: Liao
authors: Xin
authors: X
authors: Zhang
authors: Yanmin
authors: Y
authors: Liu
authors: Haiping
authors: H
authors: Zhang
authors: Chunyang
authors: C
authors: Huang
authors: Limei
authors: L
authors: Sun
authors: Huiping
authors: H
authors: Yan
mesh_terms: D000483:Alleles; D044466:Asian People; D002681:China; D005787:Gene Frequency; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I; D006801:Humans; D008105:Liver Cirrhosis, Biliary; D016133:Polymerase Chain Reaction
chemical_list: D015395:Histocompatibility Antigens Class I