title: Evaluation of the boson chemiluminescence immunoassay as a first-line screening test in the ECDC algorithm for syphilis serodiagnosis in a population with a high prevalence of syphilis.
abstract: We developed a new Boson chemiluminescence immunoassay (CIA) and evaluated its application with cross-sectional analyses. Our results indicated that the Boson CIA demonstrated strong discriminatory power in diagnosing syphilis and that it can be used as a first-line screening test for syphilis serodiagnosis using the European Centre for Disease Prevention and Control algorithm or as a confirmatory test when combined with a patient's clinical history.
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Xin-Hui
authors: XH
authors: Qiu
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Ya-Feng
authors: YF
authors: Zhang
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Yu-Yan
authors: YY
authors: Chen
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Qiao
authors: Q
authors: Zhang
authors: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
authors: Fu-Yi
authors: FY
authors: Chen
authors: Department of Chemistry and Biology, College of Science, National University of Defense and Technology, Changsha, China.
authors: Long
authors: L
authors: Liu
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Jin-Yi
authors: JY
authors: Fan
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Kun
authors: K
authors: Gao
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Xiao-Zhen
authors: XZ
authors: Zhu
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Wei-Hong
authors: WH
authors: Zheng
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Hui-Lin
authors: HL
authors: Zhang
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Li-Rong
authors: LR
authors: Lin
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Li-Li
authors: LL
authors: Liu
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China.
authors: Man-Li
authors: ML
authors: Tong
authors: Boson Biotechnology Co., Ltd., Xiamen, Xiamen, China.
authors: Chang-Gong
authors: CG
authors: Zhang
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China niujianjun211@xmu.edu.cn yangtianci@xmu.edu.cn.
authors: Jian-Jun
authors: JJ
authors: Niu
authors: Zhongshan Hospital, Medical College of Xiamen University, Xiamen, China ShenZhen Research Institute of Xiamen University, ShenZhen, China niujianjun211@xmu.edu.cn yangtianci@xmu.edu.cn.
authors: Tian-Ci
authors: TC
authors: Yang
mesh_terms: D000465:Algorithms; D002681:China / Q000453:epidemiology; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D012680:Sensitivity and Specificity; D013587:Syphilis / Q000175:diagnosis* / Q000453:epidemiology
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