title: Abdominal Fat Accumulation, as Measured by Computed Tomography, Increases the Risk of Ischemic Colitis: A Retrospective Case-Control Study.
abstract: OBJECTIVE
  Visceral fat contributes to insulin resistance and atherosclerosis. We retrospectively investigated whether abdominal fat accumulation, as measured by computed tomography, is a risk of ischemic colitis and related clinical outcomes.
  
  
  METHODS
  Outpatient-onset ischemic colitis patients (n = 58) and age- and sex-matched controls (n = 58) underwent colonoscopy and computed tomography. Associations between body mass index, visceral adipose tissue area, subcutaneous adipose tissue area, and ischemic colitis were estimated using odds ratios adjusted for hypertension, diabetes mellitus, and dyslipidemia.
  
  
  RESULTS
  In multivariate analysis, ischemic colitis was significantly associated with subcutaneous adipose tissue area (P for trend 0.030) and marginally associated with visceral adipose tissue area (P for trend 0.094), but was not associated with body mass index (P for trend 0.460). The adjusted odds ratios for the highest quartile of subcutaneous and visceral adipose tissue in ischemic colitis were 3.48 (1.06-11.4) and 2.43 (0.74-8.00), respectively, compared with the lowest quartile. When body mass index was considered simultaneously, ischemic colitis remained associated with subcutaneous adipose tissue (P for trend 0.016) and visceral adipose tissue (P for trend 0.077). No significant differences were noted between any of the obesity indices and the distribution type of colitis, blood transfusion requirement, or length of hospital stay.
  
  
  CONCLUSIONS
  Abdominal fat accumulation measured by computed tomography, but not body mass index, was associated with outpatient-onset ischemic colitis. Ischemic colitis remained associated with abdominal fat, even when body mass index was simultaneously considered. However, clinical outcomes of ischemic colitis were not associated with abdominal fat accumulation.
authors: Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan, iitomo_1020@yahoo.co.jp.
authors: Tomonori
authors: T
authors: Aoki
authors: Naoyoshi
authors: N
authors: Nagata
authors: Kayo
authors: K
authors: Sakamoto
authors: Tomohiro
authors: T
authors: Arai
authors: Ryota
authors: R
authors: Niikura
authors: Takuro
authors: T
authors: Shimbo
authors: Masafumi
authors: M
authors: Shinozaki
authors: Katsunori
authors: K
authors: Sekine
authors: Hidetaka
authors: H
authors: Okubo
authors: Kazuhiro
authors: K
authors: Watanabe
authors: Toshiyuki
authors: T
authors: Sakurai
authors: Chizu
authors: C
authors: Yokoi
authors: Junichi
authors: J
authors: Akiyama
authors: Mikio
authors: M
authors: Yanase
authors: Masashi
authors: M
authors: Mizokami
authors: Mitsuhiko
authors: M
authors: Noda
authors: Naomi
authors: N
authors: Uemura
mesh_terms: D050153:Abdominal Fat / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D000368:Aged; D016022:Case-Control Studies; D017091:Colitis, Ischemic / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
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