title: Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry.
abstract: A rapid multi-residue screening method that includes 128 veterinary anti-parasitic drugs and metabolites in meat of chicken, porcine and bovine has been developed. The scope of the method focuses on screening the following main families of veterinary anti-parasitic drugs: avermectines, benzimidazoles, the polyether ionophore, anti-tapeworm, anti-trematode, anti-piroplasmosis and chemical classes of coccodiostats. The method described a QuEChERS sample preparation procedure prior to LC-MS/MS analysis. The modified QuEChERS technology minimises sample complexity and ion suppression effects. The method was validated according to European Union guidelines (2002/657/EC) for a quantitative screening method. The validation results demonstrate that the described LC-MS/MS method provides sensitive, repeatable and meets residue screening monitoring requirements.
authors: a MOA Key Laboratory for Detection of Veterinary Drug Residues , Huazhong Agricultural University , Wuhan , Hubei , China.
authors: Huimin
authors: H
authors: Wei
authors: Yanfei
authors: Y
authors: Tao
authors: Dongmei
authors: D
authors: Chen
authors: Shuyu
authors: S
authors: Xie
authors: Yuanhu
authors: Y
authors: Pan
authors: Zhenli
authors: Z
authors: Liu
authors: Lingli
authors: L
authors: Huang
authors: Zonghui
authors: Z
authors: Yuan
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000032:analysis; D002417:Cattle; D002645:Chickens; D002853:Chromatography, Liquid; D004350:Drug Residues / Q000032:analysis; D008460:Meat / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D053719:Tandem Mass Spectrometry; D019155:Veterinary Drugs / Q000032:analysis*
chemical_list: D001562:Benzimidazoles; D010575:Pesticides; D019155:Veterinary Drugs
keywords: HPLC-MS/MS; QuEChERS; multi-residues; screening; veterinary anti-parasite drugs