title: Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?
abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
authors: Department of Pharmacy, The Fifth People's Hospital of Shanghai, Fudan University; 801 He-Qing Rd., Shanghai 200240, China. lsun@tulane.edu.
authors: Lichun
authors: L
authors: Sun
authors: Guangchun
authors: G
authors: Sun
authors: Yan
authors: Y
authors: Yu
authors: David H
authors: DH
authors: Coy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000628:therapy; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D055785:Gene Knockdown Techniques; D015316:Genetic Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000628:therapy; D058990:Molecular Targeted Therapy; D009536:Niacinamide / Q000031:analogs & derivatives / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000077157:Sorafenib; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D051880:Receptors, Notch; D009536:Niacinamide; D014635:Valproic Acid; D004317:Doxorubicin; D000077157:Sorafenib