title: Liquid-phase synthesis of bridged peptides using olefin metathesis of a protected peptide with a long aliphatic chain anchor.
abstract: Bridged peptides including stapled peptides are attractive tools for regulating protein-protein interactions (PPIs). An effective synthetic methodology in a heterogeneous system for the preparation of these peptides using olefin metathesis and hydrogenation of protected peptides with a long aliphatic chain anchor is reported.
authors: Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima , 1-78-1 Shomachi, Tokushima 770-8505, Japan.
authors: Keisuke
authors: K
authors: Aihara
authors: Chiaki
authors: C
authors: Komiya
authors: Akira
authors: A
authors: Shigenaga
authors: Tsubasa
authors: T
authors: Inokuma
authors: Daisuke
authors: D
authors: Takahashi
authors: Akira
authors: A
authors: Otaka
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D010455:Peptides