title: Elderberries: a source of ribosome-inactivating proteins with lectin activity.
abstract: Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.
authors: Nutrición y Bromatología, Facultad de Medicina and Centro de Investigación en Nutrición, Alimentación y Dietética (CINAD), Universidad de Valladolid, Valladolid 47005, Spain. jesus.tejero@uva.es.
authors: Jesús
authors: J
authors: Tejero
authors: Nutrición y Bromatología, Facultad de Medicina and Centro de Investigación en Nutrición, Alimentación y Dietética (CINAD), Universidad de Valladolid, Valladolid 47005, Spain. pilarj@bio.uva.es.
authors: Pilar
authors: P
authors: Jiménez
authors: Nutrición y Bromatología, Facultad de Medicina and Centro de Investigación en Nutrición, Alimentación y Dietética (CINAD), Universidad de Valladolid, Valladolid 47005, Spain. equinto@ped.uva.es.
authors: Emiliano J
authors: EJ
authors: Quinto
authors: Farmacia y Tecnología Farmacéutica, Facultad de Farmacia and Instituto Universitario de Farmacia Industrial (IUFI), Universidad Complutense de Madrid, Madrid 28040, Spain. damianco@farm.ucm.es.
authors: Damián
authors: D
authors: Cordoba-Diaz
authors: Biología Celular, Histología y Farmacología, Facultad de Medicina and Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Valladolid, Valladolid 47005, Spain. gayoso@med.uva.es.
authors: Manuel
authors: M
authors: Garrosa
authors: Farmacia y Tecnología Farmacéutica, Facultad de Farmacia and Instituto Universitario de Farmacia Industrial (IUFI), Universidad Complutense de Madrid, Madrid 28040, Spain. mcordoba@farm.ucm.es.
authors: Manuel
authors: M
authors: Cordoba-Diaz
authors: Biología Celular, Histología y Farmacología, Facultad de Medicina and Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Valladolid, Valladolid 47005, Spain. gayoso@med.uva.es.
authors: Manuel J
authors: MJ
authors: Gayoso
authors: Nutrición y Bromatología, Facultad de Medicina and Centro de Investigación en Nutrición, Alimentación y Dietética (CINAD), Universidad de Valladolid, Valladolid 47005, Spain. girbes@bio.uva.es.
authors: Tomás
authors: T
authors: Girbés
mesh_terms: D000818:Animals; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D058990:Molecular Targeted Therapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D054788:Ribosome Inactivating Proteins / Q000302:isolation & purification / Q000494:pharmacology* / Q000502:physiology; D027923:Sambucus / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D054788:Ribosome Inactivating Proteins
references: Annu Rev Med. 2007;58:221-37
references: 17059365
references: Curr Drug Targets. 2006 Oct;7(10):1301-11
references: 17073592
references: Arch Insect Biochem Physiol. 2010 Nov;75(3):207-20
references: 20853435
references: Tumour Biol. 2000 May-Jun;21(3):153-64
references: 10754466
references: Toxicol Appl Pharmacol. 2005 Sep 1;207(2):138-46
references: 16102565
references: Int J Biochem Cell Biol. 2003 Jul;35(7):1061-5
references: 12672476
references: Carbohydr Res. 1991 Jun 25;213:7-17
references: 1933955
references: Clin Exp Allergy. 2003 Dec;33(12):1703-10
references: 14656358
references: Semin Oncol. 2005 Dec;32(6):591-5
references: 16338425
references: FEBS Lett. 2004 Apr 9;563(1-3):219-22
references: 15063752
references: Biochem Biophys Res Commun. 1998 Aug 28;249(3):637-42
references: 9731188
references: Cancer Lett. 2007 Oct 18;256(1):73-80
references: 17637501
references: Br J Cancer. 2009 May 19;100(10):1617-26
references: 19352388
references: Mini Rev Med Chem. 2004 Jun;4(5):545-62
references: 15180510
references: Arch Insect Biochem Physiol. 2011 Apr;76(4):211-22
references: 21254203
references: Arch Biochem Biophys. 1990 Mar;277(2):255-62
references: 2310193
references: Planta. 1998 Mar;204(3):310-9
references: 9530875
references: Eur J Cancer. 2000 Mar;36(5):675-81
references: 10738134
references: Food Chem. 2013 Jan 15;136(2):794-802
references: 23122129
references: Cancer Immunol Immunother. 2013 Mar;62(3):541-51
references: 23076642
references: Biosens Bioelectron. 2014 Jul 15;57:254-61
references: 24594592
references: FEBS Lett. 1995 Mar 6;360(3):299-302
references: 7883051
references: Cell Mol Biol (Noisy-le-grand). 1996 Jun;42(4):473-6
references: 8828902
references: Cancer Lett. 2010 Dec 18;299(1):1-10
references: 20889254
references: J Ethnopharmacol. 2014 Apr 28;153(2):478-83
references: 24632015
references: Eur J Biochem. 1996 Apr 15;237(2):505-13
references: 8647092
references: Toxins (Basel). 2013 Oct 14;5(10):1767-79
references: 24129061
references: PLoS One. 2010 Sep 22;5(9):e12858
references: 20877567
references: Toxicon. 2013 Jan;61:26-9
references: 23142777
references: FEBS Lett. 1993 Jul 5;325(3):291-4
references: 8319810
references: J Agric Food Chem. 2013 Nov 20;61(46):11033-40
references: 24156563
references: J Biol Chem. 1996 Jan 19;271(3):1480-5
references: 8576142
references: Cancer Chemother Pharmacol. 2009 Nov;64(6):1261-8
references: 19363608
references: Cancer Lett. 2002 Oct 8;184(1):29-35
references: 12104045
references: Cell Mol Life Sci. 2004 Aug;61(15):1975-84
references: 15289938
references: Phytother Res. 2010 Jun;24 Suppl 2:S129-32
references: 20222152
references: AAPS J. 2006 Aug 18;8(3):E532-51
references: 17025272
references: Planta. 1986 May;168(1):113-8
references: 24233743
references: J Agric Food Chem. 2014 Jun 18;62(24):5573-80
references: 24830391
references: Anticancer Res. 1998 Jul-Aug;18(4A):2701-10
references: 9703932
references: Eur J Biochem. 2004 Apr;271(8):1508-15
references: 15066176
references: J Ethnopharmacol. 2011 Jan 27;133(2):704-9
references: 21040770
references: Plant Mol Biol. 1993 Sep;22(6):1181-6
references: 8400135
references: FASEB J. 1994 Feb;8(2):201-8
references: 8119491
references: Cell Mol Biol (Noisy-le-grand). 1997 Jun;43(4):485-99
references: 9220142
references: Phytochemistry. 2008 Dec;69(17):2972-8
references: 18951590
references: Med Chem. 2012 Nov;8(6):996-1002
references: 22779758
references: Curr Protein Pept Sci. 2010 Feb;11(1):37-53
references: 20201806
references: Eur J Biochem. 1996 Jan 15;235(1-2):128-37
references: 8631319
references: Toxins (Basel). 2011 Nov;3(11):1373-92
references: 22174975
references: Toxicon. 2004 Sep 15;44(4):371-83
references: 15302521
references: Phytopathology. 2005 Feb;95(2):206-15
references: 18943992
references: J Biochem. 2004 Apr;135(4):509-16
references: 15115776
references: Glycoconj J. 2014 Jul;31(5):345-54
references: 24853865
references: J Biol Chem. 1993 Aug 25;268(24):18195-9
references: 8349695
references: Cancer Lett. 2001 Jun 26;167(2):163-9
references: 11369137
references: Mini Rev Med Chem. 2004 Jun;4(5):563-83
references: 15180511
references: Mini Rev Med Chem. 2004 Jun;4(5):461-76
references: 15180503
references: J Biol Chem. 1987 Feb 5;262(4):1596-601
references: 3805045
references: Toxicol Rev. 2003;22(1):65-70
references: 14579548
references: Methods Mol Biol. 2014;1200:3-13
references: 25117220
references: Phytochemistry. 2008 Feb;69(4):857-64
references: 18068741
references: Biochim Biophys Acta. 1993 Dec 21;1154(3-4):237-82
references: 8280743
references: Phytother Res. 2006 Nov;20(11):961-5
references: 16906640
references: Biochim Biophys Acta. 2014 Sep;1840(9):2752-64
references: 24949982
references: Biochimie. 2010 Jan;92(1):71-80
references: 19799962
references: Med Chem. 2005 Jan;1(1):65-70
references: 16789887
references: Arch Biochem Biophys. 1997 Apr 15;340(2):185-94
references: 9143320
references: Plant Foods Hum Nutr. 2014 Jun;69(2):168-74
references: 24793353
references: FEBS Lett. 1997 Aug 11;413(1):85-91
references: 9287122
references: Proteins. 2001 May 15;43(3):319-26
references: 11288182
references: World J Gastroenterol. 2011 Jan 14;17(2):219-25
references: 21245995
references: Histol Histopathol. 2014 Aug;29(8):1057-63
references: 24563426
references: J Bacteriol. 1993 Oct;175(20):6721-4
references: 8407849
references: Toxicol Rev. 2003;22(1):53-64
references: 14579547
references: Front Biosci (Landmark Ed). 2012 Jan 01;17:670-99
references: 22201768
references: J Insect Physiol. 2014 Nov;70:94-101
references: 25240534
references: Eur J Biochem. 1997 May 1;245(3):648-55
references: 9183001
references: Nat Prod Res. 2013;27(21):2012-5
references: 23879302
references: Clin Cancer Res. 2000 May;6(5):2037-43
references: 10815930
references: J Biol Chem. 1997 Mar 28;272(13):8353-60
references: 9079659
references: J Biol Chem. 2006 Jun 23;281(25):17359-68
references: 16618699
references: Biochem J. 1991 Sep 15;278 ( Pt 3):667-71
references: 1910334
references: Adv Pharmacol. 2004;51:209-28
references: 15464911
references: Arch Toxicol. 1997;71(6):360-4
references: 9195017
references: Oncogene. 2003 Sep 29;22(42):6557-63
references: 14528280
references: Cancer Res. 1991 Dec 1;51(23 Pt 1):6236-42
references: 1718599
references: FEBS Lett. 1998 May 22;428(1-2):75-9
references: 9645479
references: Toxins (Basel). 2011 May;3(5):420-41
references: 22069717
references: J Insect Physiol. 2010 Sep;56(9):1101-7
references: 20230823