title: Spatial resolution in depth for time-resolved diffuse optical tomography using short source-detector separations.
abstract: Diffuse optical tomography for medical applications can require probes with small dimensions involving short source-detector separations. Even though this configuration is seen at first as a constraint due to the challenge of depth sensitivity, we show here that it can potentially be an asset for spatial resolution in depth. By comparing two fiber optic probes on a test object, we first show with simulations that short source-detector separations improve the spatial resolution down to a limit depth. We then confirm these results in an experimental study with a state-of-the-art setup involving a fast-gated single-photon avalanche diode allowing maximum depth sensitivity. We conclude that short source-detector separations are an option to consider for the design of probes so as to improve image quality for diffuse optical tomography in reflectance.
authors: CEA, LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors: Agathe
authors: A
authors: Puszka
authors: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors: Laura
authors: L
authors: Di Sieno
authors: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors: Alberto Dalla
authors: AD
authors: Mora
authors: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors: Antonio
authors: A
authors: Pifferi
authors: Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milano I-20133, Italy.
authors: Davide
authors: D
authors: Contini
authors: CEA, LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors: Anne
authors: A
authors: Planat-Chrétien
authors: CEA, LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors: Anne
authors: A
authors: Koenig
authors: Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo da Vinci 32 - I-20133 Milano, Italy.
authors: Gianluca
authors: G
authors: Boso
authors: Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Piazza Leonardo da Vinci 32 - I-20133 Milano, Italy.
authors: Alberto
authors: A
authors: Tosi
authors: CEA, LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors: Lionel
authors: L
authors: Hervé
authors: CEA, LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors: Jean-Marc
authors: JM
authors: Dinten
keywords: (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.6920) Time-resolved imaging; (170.6960) Tomography; (170.7050) Turbid media; (230.5160) Photodetectors
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