title: Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome.
abstract: OBJECTIVE
  The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS.
  
  
  METHODS
  A National Register-based study.
  
  
  METHODS
  Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH, n=1217). PCOS Denmark (n=19 199) included women with PCOS in the Danish National Patient Register. Three age-matched controls were included per patient (n=57 483).
  
  
  METHODS
  Diagnosis codes and filled prescriptions.
  
  
  RESULTS
  The mean (range) age of the PCOS Denmark group and controls was 30.6 (12-60) years. Patients in PCOS Denmark had higher Charlson index, higher prevalence of diabetes, dyslipidemia, and hypertension than controls. PCOS was associated with a two times increased risk of stroke and thrombosis, whereas the risk of other cardiovascular diseases was not increased. Thyroid disease, asthma, migraine, and depression were more prevalent in PCOS Denmark vs controls, whereas fractures were rarer. Infertility was increased in patients compared with controls, but the mean number of births was higher in PCOS. Medicine prescriptions within all diagnosis areas were significantly higher in PCOS patients than in controls.In PCOS OUH, polycystic ovaries (PCO) and irregular menses were associated with a more adverse metabolic risk profile, but individual Rotterdam criteria were not associated with cardiometabolic diagnoses.
  
  
  CONCLUSIONS
  Cardiometabolic and psychiatric morbidity were significantly increased in a Danish population with PCOS. Medical diseases are frequent also in young patients with PCOS.
authors: Department of EndocrinologyOdense University Hospital, Kløvervænget 6, 3rd floor, 5000 Odense C, DenmarkOPEN - Odense Patient data Explorative NetworkInstitute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark dorte.glintborg@rsyd.dk.
authors: Dorte
authors: D
authors: Glintborg
authors: Department of EndocrinologyOdense University Hospital, Kløvervænget 6, 3rd floor, 5000 Odense C, DenmarkOPEN - Odense Patient data Explorative NetworkInstitute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.
authors: Katrine
authors: K
authors: Hass Rubin
authors: Department of EndocrinologyOdense University Hospital, Kløvervænget 6, 3rd floor, 5000 Odense C, DenmarkOPEN - Odense Patient data Explorative NetworkInstitute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.
authors: Mads
authors: M
authors: Nybo
authors: Department of EndocrinologyOdense University Hospital, Kløvervænget 6, 3rd floor, 5000 Odense C, DenmarkOPEN - Odense Patient data Explorative NetworkInstitute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.
authors: Bo
authors: B
authors: Abrahamsen
authors: Department of EndocrinologyOdense University Hospital, Kløvervænget 6, 3rd floor, 5000 Odense C, DenmarkOPEN - Odense Patient data Explorative NetworkInstitute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.
authors: Marianne
authors: M
authors: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D003718:Denmark / Q000453:epidemiology; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008597:Menstrual Cycle; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology*; D017697:Premenopause; D015995:Prevalence; D012042:Registries; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D007328:Insulin; D013739:Testosterone