title: Transition-metal-free C-H oxidative activation: persulfate-promoted selective benzylic mono- and difluorination.
abstract: An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor™ as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.
authors: Nanjing University of Science and Technology, Nanjing, China. yiwenbin@mail.njust.edu.cn.
authors: Jing-jing
authors: JJ
authors: Ma
authors: Wen-bin
authors: WB
authors: Yi
authors: Guo-ping
authors: GP
authors: Lu
authors: Chun
authors: C
authors: Cai
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005459:Fluorides / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006859:Hydrogen / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D013431:Sulfates / Q000737:chemistry; D013696:Temperature; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D008670:Metals; D013431:Sulfates; D028561:Transition Elements; D005461:Fluorine; D002244:Carbon; D006859:Hydrogen; D005459:Fluorides; D010100:Oxygen