title: A case of advanced malignant pleural mesothelioma treatment with chemotherapy and photodynamic therapy.
abstract: Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant, and generally fatal disease. A 68-year-old male who was diagnosed with MPM at another hospital came to our hospital with dyspnea. We advised him to take combination chemotherapy but he refused to take the treatment. That was because he had already received chemotherapy with supportive care at another hospital but his condition worsened. Thus, we recommended photodynamic therapy (PDT) to deal with the dyspnea and MPM. After PDT, the dyspnea improved and the patient then decided to take the combination chemotherapy. Our patient received chemotherapy using pemetrexed/cisplatin. Afterwards, he received a single PDT treatment and then later took chemotherapy using gemcitabine/cisplatin. The patient showed a survival time of 27 months, which is longer than median survival time in advanced MPM patients. Further research and clinical trials are needed to demonstrate any synergistic effect between the combination chemotherapy and PDT.
authors: Department of Thoracic and Cardiovascular Surgery, Dankook University College of Medicine, Cheonan, Korea.
authors: Jae-Wook
authors: JW
authors: Ryu
authors: Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
authors: Youn Seup
authors: YS
authors: Kim
keywords: Chemotherapy; Mesothelioma, Malignant; Photodynamic Therapy; Pleura
references: Ann Thorac Surg. 1994 Oct;58(4):995-8
references: 7944821
references: Ann Thorac Surg. 1998 Oct;66(4):1128-33
references: 9800793
references: Chest. 2004 Oct;126(4):1318-29
references: 15486399
references: Pak J Med Sci. 2013 Nov;29(6):1433-8
references: 24550969
references: Curr Opin Ophthalmol. 2000 Jun;11(3):166-70
references: 10977221
references: CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81
references: 21617154
references: Chest. 2001 Oct;120(4):1167-74
references: 11591556
references: Ann Surg Oncol. 1997 Dec;4(8):628-33
references: 9416409
references: Thorac Surg Clin. 2004 Nov;14(4):557-66
references: 15559063
references: Immunol Res. 2010 Mar;46(1-3):216-26
references: 19763892
references: Ann Cardiothorac Surg. 2012 Nov;1(4):472-80
references: 23977539
references: Semin Thorac Cardiovasc Surg. 2009 Summer;21(2):125-31
references: 19822284
references: World J Surg. 2001 Feb;25(2):210-7
references: 11338024
references: Semin Thorac Cardiovasc Surg. 2009 Summer;21(2):177-87
references: 19822291
references: J Clin Oncol. 2003 Jul 15;21(14):2636-44
references: 12860938