title: Regenerative medicine: targeted genome editing in vivo.
abstract: The CRISPR/Cas system has proven to be a powerful gene editing tool both in vitro and in vivo. A recent flurry of studies of in vivo gene editing using the CRISPR/Cas system bring bright prospects in creating animal models and targeted gene therapy of human genetic diseases.
authors: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors: Lixia
authors: L
authors: Wang
authors: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Jun
authors: J
authors: Wu
authors: Beijing Hospital of the Ministry of Health, Beijing 100730, China.
authors: Weiwei
authors: W
authors: Fang
authors: 1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Beijing Institute for Brain Disorders, Beijing 100069, China [3] Center for Molecular and Translational Medicine, Beijing 100101, China.
authors: Guang-Hui
authors: GH
authors: Liu
authors: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors: Juan Carlos
authors: JC
authors: Izpisua Belmonte
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism* / Q000637:transplantation*; D000818:Animals; D064113:CRISPR-Cas Systems; D005260:Female; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy*; D008297:Male; D016296:Mutagenesis
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