title: A prospective multicentric study of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease and different clinical phenotypes.
abstract: BACKGROUND
  Recently, it has been proposed that different clinical phenotypes can be recognized in patients with chronic obstructive disease (COPD), namely predominant airway disease or parenchymal destructive changes.
  
  
  OBJECTIVE
  The aim of this prospective multicenter study was to evaluate whether these two phenotypes may influence outcomes following a pulmonary rehabilitation program (PRP).
  
  
  METHODS
  We have prospectively evaluated 364 consecutive COPD patients (70 ± 8 years, 76.3% males) admitted to a standard hospital-based PRP in 6 Italian centers. According to their phenotype, the study cohort was divided into two groups: patients with airway obstructive (group 1, n = 208) or parenchymal destructive COPD (group 2, n = 156). Before and after PRP, values of 6-min walking distance, perceived breathlessness (Medical Research Council), health-related quality of life (St. George's Respiratory Questionnaire) and respiratory muscle function (maximal inspiratory and expiratory pressure) were recorded.
  
  
  RESULTS
  PRP resulted in significant improvements in all outcome measures without any significant differences between groups.
  
  
  CONCLUSIONS
  Our study confirms that COPD patients may benefit from pulmonary rehabilitation independent of their clinical phenotype.
authors: Weaning and Rehabilitation Unit, Auxilium Vitae Rehabilitation Center, Volterra, Italy.
authors: Nicolino
authors: N
authors: Ambrosino
authors: Elena
authors: E
authors: Venturelli
authors: Francesco
authors: F
authors: de Blasio
authors: Pierluigi
authors: P
authors: Paggiaro
authors: Franco
authors: F
authors: Pasqua
authors: Michele
authors: M
authors: Vitacca
authors: Guido
authors: G
authors: Vagheggini
authors: Enrico M
authors: EM
authors: Clini
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000534:rehabilitation*