title: Altered salience network connectivity predicts macronutrient intake after sleep deprivation.
abstract: Although insufficient sleep is a well-recognized risk factor for overeating and weight gain, the neural mechanisms underlying increased caloric (particularly fat) intake after sleep deprivation remain unclear. Here we used resting-state functional magnetic resonance imaging and examined brain connectivity changes associated with macronutrient intake after one night of total sleep deprivation (TSD). Compared to the day following baseline sleep, healthy adults consumed a greater percentage of calories from fat and a lower percentage of calories from carbohydrates during the day following TSD. Subjects also exhibited increased brain connectivity in the salience network from the dorsal anterior cingulate cortex (dACC) to bilateral putamen and bilateral anterior insula (aINS) after TSD. Moreover, dACC-putamen and dACC-aINS connectivity correlated with increased fat and decreased carbohydrate intake during the day following TSD, but not during the day following baseline sleep. These findings provide a potential neural mechanism by which sleep loss leads to increased fat intake.
authors: Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Zhuo
authors: Z
authors: Fang
authors: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Andrea M
authors: AM
authors: Spaeth
authors: Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Ning
authors: N
authors: Ma
authors: Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Senhua
authors: S
authors: Zhu
authors: Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Siyuan
authors: S
authors: Hu
authors: Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Namni
authors: N
authors: Goel
authors: Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: John A
authors: JA
authors: Detre
authors: Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: David F
authors: DF
authors: Dinges
authors: 1] Center for Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA [2] Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors: Hengyi
authors: H
authors: Rao
mesh_terms: D000328:Adult; D015992:Body Mass Index; D050260:Carbohydrate Metabolism / Q000502:physiology; D004032:Diet; D002149:Energy Intake; D005223:Fats / Q000378:metabolism; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012892:Sleep Deprivation / Q000378:metabolism / Q000473:pathology*
chemical_list: D005223:Fats
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