title: Does rituximab help in HLA desensitization for kidney transplantation?
abstract: In the study by Jackson et al., 50 subjects were given plasma exchange and low-dose intravenous immunoglobulin to desensitize for live-donor kidney transplantation, and those deemed to have high immunological risk were also given rituximab. Transplant outcomes were similar between the two groups even though the rituximab group had higher immunological risk. These results suggest that rituximab may be helpful when added to 'standard' desensitization protocols, but definitive trials are still lacking in this area.
authors: Central Northern Adelaide Renal and Transplantation Services, Renal Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors: Robert
authors: R
authors: Carroll
authors: Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
authors: P Toby
authors: PT
authors: Coates
mesh_terms: D005260:Female; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D016030:Kidney Transplantation; D008297:Male; D000069283:Rituximab / Q000627:therapeutic use*
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies; D000069283:Rituximab