title: Melatonin lowers edema after spinal cord injury.
abstract: Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Cheng
authors: C
authors: Li
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Xiao
authors: X
authors: Chen
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Suchi
authors: S
authors: Qiao
authors: Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning Province, China.
authors: Xinwei
authors: X
authors: Liu
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Chang
authors: C
authors: Liu
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Degang
authors: D
authors: Zhu
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Jiacan
authors: J
authors: Su
authors: Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
authors: Zhiwei
authors: Z
authors: Wang
keywords: aquaporin; edema; glial fibrillary acidic protein; immunohistochemistry; melatonin; nerve regeneration; neural regeneration; spinal cord injury; western blot assay
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