title: Advancing the development of glycated protein biosensing technology: next-generation sensing molecules.
abstract: Research advances in biochemical molecules have led to the development of convenient and reproducible biosensing molecules for glycated proteins, such as those based on the enzymes fructosyl amino acid oxidase (FAOX) or fructosyl peptide oxidase (FPOX). Recently, more attractive biosensing molecules with potential applications in next-generation biosensing of glycated proteins have been aggressively reported. We review 2 such molecules, fructosamine 6-kinase (FN6K) and fructosyl amino acid-binding protein, as well as their recent applications in the development of glycated protein biosensing systems. Research on FN6K and fructosyl amino acid-binding protein has been opening up new possibilities for the development of highly sensitive and proteolytic-digestion-free biosensing systems for glycated proteins.
authors: Department of Biotechnology & Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Miho
authors: M
authors: Kameya
authors: Department of Medical Technology, School of Health Sciences, Graduate School of Bionics, Computer and Media Sciences, Tokyo University of Technology, Tokyo, Japan.
authors: Akane
authors: A
authors: Sakaguchi-Mikami
authors: Department of Biotechnology & Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Stefano
authors: S
authors: Ferri
authors: Department of Biotechnology & Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Wakako
authors: W
authors: Tsugawa
authors: Department of Biotechnology & Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan Ultizyme International Ltd, Tokyo, Japan sode@cc.tuat.ac.jp.
authors: Koji
authors: K
authors: Sode
mesh_terms: D000594:Amino Acid Oxidoreductases; D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D019270:Fructosamine; D006801:Humans
chemical_list: D015415:Biomarkers; D019270:Fructosamine; D000594:Amino Acid Oxidoreductases; C103012:amadoriase; C520096:fructosyl-peptide oxidase
keywords: biosensing; fructosamine 6-kinase; fructosyl amino acid-binding protein; glycated albumin; glycated protein; hemoglobin A1c
references: Diabetes. 2000 Oct;49(10):1627-34
references: 11016445
references: Diabetes. 2001 Sep;50(9):2139-47
references: 11522682
references: Diabetes Technol Ther. 2001 Winter;3(4):609-16
references: 11911173
references: Anal Bioanal Chem. 2002 Jul;373(4-5):211-4
references: 12110969
references: Protein Sci. 2002 Nov;11(11):2655-75
references: 12381848
references: J Biol Chem. 2002 Nov 8;277(45):42523-9
references: 12147680
references: Clin Chem. 2003 Feb;49(2):269-74
references: 12560350
references: N Engl J Med. 1984 Feb 9;310(6):341-6
references: 6690962
references: Biosens Bioelectron. 2003 Oct 15;18(12):1485-90
references: 12941564
references: Diabetes. 2003 Dec;52(12):2888-95
references: 14633848
references: FEMS Microbiol Lett. 2004 Jun 1;235(1):157-62
references: 15158276
references: J Mol Biol. 2004 Jul 9;340(3):477-89
references: 15210349
references: Proc Biol Sci. 1990 Nov 22;242(1304):87-90
references: 1981619
references: J Bacteriol. 1991 May;173(10):3117-27
references: 1850730
references: Protein Sci. 1993 Jan;2(1):31-40
references: 8382990
references: Microbiol Rev. 1993 Jun;57(2):320-46
references: 8336670
references: J Biol Chem. 1994 Nov 4;269(44):27297-302
references: 7961640
references: J Biol Chem. 1995 Jul 7;270(27):16097-106
references: 7608172
references: J Mol Biol. 1998 Apr 24;278(1):219-29
references: 9571045
references: FEBS Lett. 2004 Nov 19;577(3):469-72
references: 15556630
references: Biochem Biophys Res Commun. 2005 Nov 4;336(4):1074-80
references: 16169524
references: J Biol Chem. 2006 Jul 7;281(27):18378-85
references: 16670083
references: J Am Soc Nephrol. 2007 Mar;18(3):896-903
references: 17267743
references: Biosens Bioelectron. 2007 Apr 15;22(9-10):1933-8
references: 17015009
references: Adv Enzyme Regul. 2007;47:261-9
references: 17337043
references: Clin Biochem. 2008 May;41(7-8):576-83
references: 18261468
references: Mol Diagn Ther. 2010 Feb 1;14(1):49-51
references: 20121290
references: J Diabetes Sci Technol. 2009 May;3(3):585-92
references: 20144298
references: Biotechnol Lett. 2010 Aug;32(8):1123-9
references: 20383736
references: Appl Microbiol Biotechnol. 2011 Apr;90(2):399-406
references: 21347729
references: Appl Environ Microbiol. 2011 May;77(9):2839-46
references: 21398478
references: Biotechnol Lett. 2012 Mar;34(3):491-7
references: 22052257
references: J Diabetes Sci Technol. 2012;6(6):1286-95
references: 23294773
references: Biotechnol Lett. 2013 Feb;35(2):253-8
references: 23076362
references: J Diabetes Sci Technol. 2013;7(1):13-23
references: 23439156
references: J Diabetes Sci Technol. 2013;7(1):62-71
references: 23439161
references: J Appl Microbiol. 2013 May;114(5):1449-56
references: 23360325
references: Appl Biochem Biotechnol. 2013 Jun;170(3):710-7
references: 23609907
references: Diabetes Care. 2014 Jan;37 Suppl 1:S14-80
references: 24357209
references: Clin Chim Acta. 2014 Jun 10;433:96-104
references: 24631132
references: Diabetes Care. 2004 Jul;27(7):1761-73
references: 15220264
references: Biochem J. 2004 Aug 15;382(Pt 1):137-43
references: 15137908
references: J Clin Invest. 1976 Jun;57(6):1652-9
references: 932199