title: Cytochromes P450 for terpene functionalisation and metabolic engineering.
abstract: Plants have evolved the capacity to produce a striking array of specialised metabolites. Terpenoids are the oldest and most diverse class of such compounds and have attracted interest for industrial and pharmaceutical applications. The development of biotechnological alternatives for their production is the focus of intense research. Photosynthetic systems provide new strategies for autotrophic metabolic engineering. Focusing on cytochromes P450, involved in the functionalisation of the core terpene molecules, this review highlights the latest approaches in this field and looks towards recent discoveries that have the potential to shape the future of terpenoid bioengineering.
authors: Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871, Copenhagen, Denmark.
authors: Irini
authors: I
authors: Pateraki
authors: Allison Maree
authors: AM
authors: Heskes
authors: Björn
authors: B
authors: Hamberger
mesh_terms: D001419:Bacteria / Q000378:metabolism; D001709:Biotechnology / Q000379:methods; D044002:Bryophyta / Q000378:metabolism; D002244:Carbon / Q000737:chemistry; D002736:Chloroplasts / Q000737:chemistry; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D014644:Genetic Variation; D060847:Metabolic Engineering / Q000379:methods*; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry; D010944:Plants / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry*; D015003:Yeasts / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D011994:Recombinant Proteins; D013729:Terpenes; D002244:Carbon; D003577:Cytochrome P-450 Enzyme System