title: Diabetic foot disease: grading inflammation by apolipoprotein A-I, C-reactive protein and serum amyloid A.
abstract: BACKGROUND
  The different grading systems for diabetic foot disease pose a challenge in clinical decision making because each system fails to accurately reflect the individual course of disease progression. This study attempts to identify laboratory measurements for classifying diabetic foot disease to guide clinical treatment.
  
  
  METHODS
  The sera of 111 clinically graded diabetic foot patients were measured for several laboratory parameters including serum amyloid A (SAA), C-reactive protein (CRP), and apo A-I. By using the molar sum of CRP and SAA and then dividing by the molarity of apo A-I, an acute phase index was introduced to assess the inflammatory status of the patients.
  
  
  RESULTS
  Based on a newly defined acute phase index (API), diabetic foot patients were classified into 3 distinct groups that provide a diagnostic tool complementing the established Texas grading system for clinical decision making.
  
  
  CONCLUSIONS
  The integration of the serum concentrations of SAA, CRP and apo A-I into an acute phase index (API) offers an opportunity to triage diabetic foot patients who may benefit from personalized medicine.
authors: Weiling
authors: W
authors: Wang
authors: Yan
authors: Y
authors: Zhang
authors: Yonggan
authors: Y
authors: Liao
authors: Jun
authors: J
authors: Wu
authors: Lixia
authors: L
authors: Zhou
authors: Yijun
authors: Y
authors: Tang
authors: Yang
authors: Y
authors: Cao
authors: Erwin
authors: E
authors: Metzmann
authors: Rongfang
authors: R
authors: Wang
mesh_terms: D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003661:Decision Support Techniques; D017719:Diabetic Foot / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D000685:Serum Amyloid A Protein / Q000032:analysis*; D012720:Severity of Illness Index
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D015415:Biomarkers; D018836:Inflammation Mediators; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein