title: Fluorination of 2-substituted benzo[b]furans with Selectfluor™.
abstract: An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor™ as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.
authors: Department of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. sunxunf@shmu.edu.cn.
authors: Mingliang
authors: M
authors: Wang
authors: Xixi
authors: X
authors: Liu
authors: Lu
authors: L
authors: Zhou
authors: Jidong
authors: J
authors: Zhu
authors: Xun
authors: X
authors: Sun
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D003979:Diazonium Compounds / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D003979:Diazonium Compounds; D006845:Hydrocarbons, Fluorinated; C408750:selectfluor; C105430:benzofuran