title: HAM/TSP and major depression: the role of age.
abstract: OBJECTIVE
  To investigate the role of demographic variables in the relationship between the presence of HAM/TSP and current major depression.
  
  
  METHODS
  It is a cross-sectional study of 108 HTLV-1 infected patients (47 with TSP/HAM) resident of Salvador, Brazil. The Mini International Neuropsychiatric Interview, Brazilian Version 5 was used to evaluate the presence of depression. Prevalence ratios were used to describe relationship between HAM/TSP and depression. The HAM/TSP classification was carried out according to the criteria proposed by Castro-Costa et al.
  
  
  RESULTS
  Prevalence of depression was 37.96%. No association was observed between presence of HAM/TSP and diagnosis of current major depression in the global analysis of patients (PR: 0.94; CI 95%: 0.57-1.55). In the stratified analysis, however, greater prevalence of depression was observed amongst individuals with HAM/TSP in the 18-39 age group (PR: 2.59; CI 95%: 1.36-4.95).
  
  
  CONCLUSIONS
  Our findings suggest that age is an effect modifier in the relationship between HAM/TSP and depression, and this aspect should be considered in future studies on the topic.
authors: Reference Center for HTLV, Bahiana School of Medicine and Public Health Salvador, Salvador, BA, Brazil. Electronic address: neyboasorte@bahiana.edu.br.
authors: Ney
authors: N
authors: Boa-Sorte
authors: Reference Center for HTLV, Bahiana School of Medicine and Public Health Salvador, Salvador, BA, Brazil.
authors: Ana Verena
authors: AV
authors: Galvão-Castro
authors: Foundation for Science Development, Salvador, BA, Brazil.
authors: Danilo
authors: D
authors: Borba
authors: Reference Center for HTLV, Bahiana School of Medicine and Public Health Salvador, Salvador, BA, Brazil.
authors: Renan Barbalho Nunes de Castro
authors: RB
authors: Lima
authors: Reference Center for HTLV, Bahiana School of Medicine and Public Health Salvador, Salvador, BA, Brazil.
authors: Bernardo
authors: B
authors: Galvão-Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000523:psychology*; D015995:Prevalence; D012959:Socioeconomic Factors; D019562:Viral Load; D055815:Young Adult
keywords: Age factors; Depression; HTLV-1 associated myelopathies; Human T-lymphotropic virus 1
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