title: Diagnostic Value of Serum d-Dimer Level for Tubo-Ovarian Abscess: A Cross-Sectional Pilot Study.
abstract: Aim of this study is to investigate the diagnostic role of serum D-dimer levels for tubo-ovarian abscess (TOA). Patients diagnosed with TOA (n = 36) and matched controls with ovarian cysts (n = 39) were collected prospectively. Patients in the 2 groups were compared on the basis of size of TOA or cyst, demographic characteristics, and serum d-dimer levels. Baseline characteristics of both groups were comparable. Mean D-dimer levels were significantly higher (P < .0001) in patients with TOA (1870.6 ± 2401.7 ng/mL) when compared to adnexal cyst group (164.4 ± 81.1 ng/mL). D-Dimer had a diagnostic value of 99.9%, specificity of 100.0%, and sensitivity of 97.4% based on a cutoff value 314 ng/mL for predicting TOA. In conclusion, serum d-dimer level was significantly elevated in women with TOA compared with benign adnexal cysts. Thus, this inexpensive, feasible, and reproducible marker can be used for differential diagnosis of TOA.
authors: Department of Obstetrics and Gynaecology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey drbulentyilmaz@yahoo.com.
authors: Bulent
authors: B
authors: Yilmaz
authors: Department of Obstetrics and Gynaecology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors: Burcu
authors: B
authors: Kasap
authors: Department of Obstetrics and Gynaecology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
authors: Mustafa
authors: M
authors: Demir
authors: Department of Obstetrics and Gynaecology, Tepecik Education and Research Hospital, Izmir, Turkey.
authors: Kemal
authors: K
authors: Gungorduk
authors: Department of Obstetrics and Gynaecology, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
authors: Sefa
authors: S
authors: Kelekci
authors: Department of Medical Biochemistry, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
authors: Recep
authors: R
authors: Sutcu
mesh_terms: D000038:Abscess / Q000097:blood* / Q000175:diagnosis; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005184:Fallopian Tube Diseases / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D010048:Ovarian Cysts / Q000097:blood / Q000175:diagnosis; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: d-dimer; ovarian cyst; pelvic inflammatory disease; tubo-ovarian abscess