title: Synergistic induction of cell death in haematological malignancies by combined phosphoinositide-3-kinase and BET bromodomain inhibition.
authors: Department of Haematology, University College London Cancer Institute, London, UK.
authors: Steven
authors: S
authors: Tinsley
authors: Department of Haematology, University College London Cancer Institute, London, UK.
authors: Koremu
authors: K
authors: Meja
authors: Department of Haematology, University College London Cancer Institute, London, UK.
authors: Clare
authors: C
authors: Shepherd
authors: Department of Haematology, University College London Cancer Institute, London, UK. a.khwaja@ucl.ac.uk.
authors: Asim
authors: A
authors: Khwaja
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018797:Cell Cycle Proteins; D016923:Cell Death / Q000187:drug effects; D004357:Drug Synergism; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage; D014157:Transcription Factors / Q000037:antagonists & inhibitors*; D000092468:Bromodomain Containing Proteins
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D014157:Transcription Factors; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins
keywords: JQ1; MYC; PI3K; apoptosis; bromodomain containing 4