title: Using Spatial Disease Patterns and Patient-Level Characteristics to Describe Prevalence Elastic Behavior in Treatment for Latent Tuberculosis Infection (LTBI).
abstract: OBJECTIVE
  Individual adherence to a 9-month regimen of isoniazid (9INH) for treatment of latent tuberculosis infection (LTBI) was hypothesized to reflect a prevalent elastic health behavior pattern, or prevention behavior correlated with relevant disease burden.
  
  
  METHODS
  Log-rank tests were used to compare survival functions among raw prevalence tertiles for diseases including TB, diabetes, and obesity. Own and cross-prevalence elasticities were calculated and spatially characterized behavioral response to diseases that may impact TB re-infection and/or re-activation. Discrete choice models were used to assess the significance of the spatial elasticities among an ethnically diverse clinic population of 552 patients in an urban American county in 2010.
  
  
  RESULTS
  Log-rank results revealed a statistical association between dropout and chronic disease prevalence (p < .01), but not TB prevalence (p = .13). Discrete choice models incorporating spatial elasticities and controlling for patient- and treatment-level characteristics demonstrated significant associations with adherence (p < .01), an effect robust to various alternative treatment definitions.
  
  
  CONCLUSIONS
  Individual LTBI adherence tracks a prevalence elastic pattern that may represent a potential risk for re-infection and re-activation.
authors: Agricultural, Environmental, and Development Economics, College of Food, Agriculture and Environmental Sciences and Division of Epidemiology, College of Public Health, Ohio State University, Columbus, Ohio.|Institute of Health and Environmental Research (IHER), Cleveland, Ohio.|Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106.
authors: Kyle R
authors: KR
authors: Fluegge
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D062206:Spatial Analysis; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid
keywords: adherence; diabetes; isoniazid; latent tuberculosis infection; prevalence elasticity; rifampin