title: Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan.
abstract: We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.
authors: Department of Intensive Care Medicine, Chi Mei Medical Centre, Tainan City, Taiwan; Department of Medicine, Taipei Medical University, Taipei City, Taiwan.
authors: W-L
authors: WL
authors: Yu
authors: Department of Medical Research, Chi Mei Medical Centre, Tainan City, Taiwan.
authors: M-F
authors: MF
authors: Lee
authors: Department of Internal Medicine, Chi Mei Medical Centre, Tainan City, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan City, Taiwan.
authors: H-J
authors: HJ
authors: Tang
authors: College of Medicine and Nursing, HungKuang University, Taichung City, Taiwan.
authors: M-C
authors: MC
authors: Chang
authors: Department of Clinical Microbiology, National University Hospital, Copenhagen, Denmark.
authors: J
authors: J
authors: Walther-Rasmussen
authors: Department of Medical Research, Chi Mei Medical Centre, Tainan City, Taiwan; Department of Internal Medicine, Chi Mei Medical Centre-Liou Ying, Tainan City, Taiwan. Electronic address: chuangkenneth@hotmail.com.
authors: Y-C
authors: YC
authors: Chuang
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D058889:Molecular Typing; D013624:Taiwan / Q000453:epidemiology; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D001618:beta-Lactamases; D008911:Minocycline; D003091:Colistin
keywords: Carbapenemase; KPC-16; KPC-17; KPC-2; Klebsiella pneumoniae