title: Effect of in vitro transcorneal approach of aceclofenac eye drops through excised goat, sheep, and buffalo corneas.
abstract: The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1-0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different formulations was estimated using an Franz diffusion cell. A linear increase in drug permeation was observed with increase in pH (5.5 to 7.4). The apparent permeability coefficient was found to be maximum 15.01 ± 0.45 on goat cornea and maximum transport of aceclofenac was observed at physiological pH of tears (i.e., 7). The results advocate that aceclofenac 0.5% (w/v) ophthalmic solution (pH 7.0) containing BAK (0.01%) provides maximum in vitro ocular permeability through goat, sheep, and buffalo corneas.
authors: Department of Pharmacy, Banasthali University, Banasthali 304022, India.
authors: Vivek
authors: V
authors: Dave
authors: Department of Pharmacy, Banasthali University, Banasthali 304022, India.
authors: Sarvesh
authors: S
authors: Paliwal
authors: Department of Pharmacy, Banasthali University, Banasthali 304022, India.
authors: Sachdev
authors: S
authors: Yadav
authors: Department of Pharmacy, Banasthali University, Banasthali 304022, India.
authors: Swapnil
authors: S
authors: Sharma
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002020:Buffaloes; D003315:Cornea / Q000378:metabolism*; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006041:Goats; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D012756:Sheep
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac; C056498:aceclofenac
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