title: Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice.
abstract: OBJECTIVE
  To investigate the effects of San-Huang-Xie-Xin-Tang (SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice.
  
  
  METHODS
  The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).
  
  
  RESULTS
  In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT (0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT (0.1-1 g/kg).
  
  
  CONCLUSIONS
  These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Min Woo
authors: MW
authors: Hwang
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Tae Seok
authors: TS
authors: Ahn
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Noo Ri
authors: NR
authors: Hong
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Han-Sol
authors: HS
authors: Jeong
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Myeong Ho
authors: MH
authors: Jung
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Ki-Tae
authors: KT
authors: Ha
authors: Min Woo Hwang, Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
authors: Byung Joo
authors: BJ
authors: Kim
mesh_terms: D019342:Acetic Acid; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D008813:Mice, Inbred ICR; D013311:Streptozocin; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents; C501029:San-Huang-Xie-Xin-Tang; D013311:Streptozocin; D019342:Acetic Acid
keywords: Gastrointestinal disorders; Gastrointestinal tract; Intestinal transit rate; Motility; San-Huang-Xie-Xin-Tang
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