title: BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers.
abstract: Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).
authors: Dept of Respiratory Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France Faculty of Medicine Lyon-Sud Charles Mérieux, Lyon 1 University, Lyon, France Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada sebastien.couraud@chu-lyon.fr.
authors: Sébastien
authors: S
authors: Couraud
authors: Dept of Respiratory Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France Faculty of Medicine Lyon-Sud Charles Mérieux, Lyon 1 University, Lyon, France.
authors: Pierre-Jean
authors: PJ
authors: Souquet
authors: (CP) INGRES, EA7298, Lorraine University, Vandoeuvre Les Nancy, France.
authors: Christophe
authors: C
authors: Paris
authors: Francois Baclesse Cancer Institute, Caen, France.
authors: Pascal
authors: P
authors: Dô
authors: Pulmonology Unit, Foch General Hospital, Paris, France.
authors: Hélène
authors: H
authors: Doubre
authors: Pulmonology Unit, University Hospital of Tours, Tours, France François Rabelais University, Respiratory Diseases Study Centre, U1100/EA6305, Tours, France.
authors: Eric
authors: E
authors: Pichon
authors: Pulmonology Unit, Orleans Regional Hospital, Orléans, France.
authors: Adrien
authors: A
authors: Dixmier
authors: Pulmonology Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
authors: Isabelle
authors: I
authors: Monnet
authors: Dept of Respiratory Medicine, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France Claude Bernard University Lyon 1, Lyon, France.
authors: Bénédicte
authors: B
authors: Etienne-Mastroianni
authors: Pulmonology Dept, Saint Joseph-Saint Luc Hospital, Lyon, France.
authors: Michel
authors: M
authors: Vincent
authors: Pulmonology Dept, Paris - Saint Joseph Hospital, and Sorbonne Paris Cité University, Paris, France.
authors: Jean
authors: J
authors: Trédaniel
authors: Pulmonology Dept, Bourg-en-Bresse General Hospital, Bourg en Bresse, France.
authors: Marielle
authors: M
authors: Perrichon
authors: Thoracic Oncology, Dijon University Hospital, Dijon, France.
authors: Pascal
authors: P
authors: Foucher
authors: Oncology Dept, Georges François Leclerc Cancer Centre, Dijon, France.
authors: Bruno
authors: B
authors: Coudert
authors: Pulmonology and Thoracic Oncology Dept, Grenoble University Hospital, Grenoble, France Medicine Faculty, Joseph Fourrier University, La Tronche, France.
authors: Denis
authors: D
authors: Moro-Sibilot
authors: Oncology Dept, Oscar Lambret Cancer Centre, Lille, France.
authors: Eric
authors: E
authors: Dansin
authors: Dept of Respiratory Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France Faculty of Medicine Lyon-Sud Charles Mérieux, Lyon 1 University, Lyon, France.
authors: Stéphanie
authors: S
authors: Labonne
authors: Intergroupe Francophone de Cancérologie Thoracique, Paris, France.
authors: Pascale
authors: P
authors: Missy
authors: Intergroupe Francophone de Cancérologie Thoracique, Paris, France.
authors: Franck
authors: F
authors: Morin
authors: Fondation Jean Dausset - CEPH, Paris, France.
authors: Hélène
authors: H
authors: Blanché
authors: Pulmonology and Thoracic Oncology Dept, Caen University Hospital, and UMR INSERM 1086, Caen Basse-Normandie University, Caen, France.
authors: Gérard
authors: G
authors: Zalcman
mesh_terms: D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D015415:Biomarkers / Q000378:metabolism; D002273:Carcinogens; D015331:Cohort Studies; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D005602:France; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics; D016273:Occupational Exposure; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000077548:Anaplastic Lymphoma Kinase; D015415:Biomarkers; D002273:Carcinogens; D066246:ErbB Receptors; D009687:Nuclear Proteins; D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras); D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D014028:Tobacco Smoke Pollution; D014157:Transcription Factors; C117307:KRAS protein, human; C503859:PI3KCA protein, human; C000626173:ALK protein, human; C512478:EGFR protein, human; C508053:ERBB2 protein, human; C482119:BRAF protein, human