title: Polymer brushes interfacing blood as a route toward high performance blood contacting devices.
abstract: In the current study, well-defined polymer brushes are shown as an effective surface modification to resist the adhesion of whole blood and its components. Poly[oligo(ethylene glycol)methylether methacrylate] (poly(MeOEGMA)), poly(hydroxyethyl methacrylate) (poly(HEMA)), poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)), and poly(carboxybetaine acrylamide) (poly(CBAA)) brushes were grown by surface initiated atom transfer radical polymerization (SI-ATRP) and subsequently characterized by Fourier-transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), dynamic contact angle measurements, atomic force microscopy (AFM), and surface plasmon resonance (SPR) spectroscopy. All brushes decreased the fouling from blood plasma over 95% and prevented the adhesion of platelets, erythrocytes, and leukocytes as evidenced by SPR and SEM measurements.
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 162 06, Czech Republic.
authors: František
authors: F
authors: Surman
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 162 06, Czech Republic.
authors: Tomáš
authors: T
authors: Riedel
authors: Institute for Applied Materials (IAM), Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
authors: Michael
authors: M
authors: Bruns
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 162 06, Czech Republic.
authors: Nina Yu
authors: NY
authors: Kostina
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 162 06, Czech Republic.
authors: Zdeňka
authors: Z
authors: Sedláková
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Prague, 162 06, Czech Republic. rodriguez@imc.cas.cz.
authors: Cesar
authors: C
authors: Rodriguez-Emmenegger
mesh_terms: D057219:Biofouling; D001769:Blood / Q000378:metabolism*; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D006801:Humans; D008422:Materials Testing / Q000295:instrumentation*; D018625:Microscopy, Atomic Force; D056951:Photoelectron Spectroscopy; D053657:Platelet-Rich Plasma; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014867:Water
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D014867:Water
keywords: blood compatibility; blood plasma; non-fouling; proteins; surfaces