title: Hyaluronan in non-surgical and surgical periodontal therapy: a systematic review.
abstract: OBJECTIVE
  To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy.
  
  
  METHODS
  Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) pre-clinical in vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinically.
  
  
  RESULTS
  Two pre-clinical in vivo studies on surgical treatment and 12 clinical trials on non-surgical and/or surgical treatment were included. Most of the studies were highly heterogeneous, regarding with HY product used and application mode, and of high risk of bias, thus not allowing meta-analysis. The majority of clinical studies described a beneficial, occasionally statistically significant, effect of HY on bleeding on probing (BoP) and pocket depth (PD) reduction (2.28-19.5% and 0.2-0.9 mm, respectively), comparing to controls; no adverse effects were reported.
  
  
  CONCLUSIONS
  Hyaluronan application as adjunct to non-surgical and surgical periodontal treatment seems to have a beneficial, generally moderate, effect on surrogate outcome variables of periodontal inflammation, i.e., BoP and residual PD, and appears to be safe. The large heterogeneity of included studies, does not allow recommendations on the mode of application or effect size of HY as adjunct to non-surgical and surgical periodontal treatment.
authors: Department of Periodontology, Faculty of Odontology, University of Malmö, Malmö, Sweden; Division of Oral Surgery, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.
authors: Kristina
authors: K
authors: Bertl
authors: Corinna
authors: C
authors: Bruckmann
authors: Per-Erik
authors: PE
authors: Isberg
authors: Björn
authors: B
authors: Klinge
authors: Klaus
authors: K
authors: Gotfredsen
authors: Andreas
authors: A
authors: Stavropoulos
mesh_terms: D003131:Combined Modality Therapy; D005884:Gingival Hemorrhage / Q000601:surgery / Q000628:therapy; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000601:surgery / Q000628:therapy*; D010514:Periodontal Pocket / Q000601:surgery / Q000628:therapy; D055675:Viscosupplements / Q000627:therapeutic use*
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: clinical trials; hyaluronan; hyaluronate; hyaluronic acid; periodontitis; systematic review