title: Protein 53 expression in a mixed Labrador subcutaneous lymphoma.
abstract: An 11 year - old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positive in the immunohistochemical staining and most of them were accumulated around vessels. Protein 53 (p53) expression was detected by brown nuclei in immunohistochemical staining. Subcutaneous lymphoma was diagnosed according to histopathological results. After 6 months the case was referred with multicentric lymphoma and based on the owner request euthanasia was performed. These findings emphasize on poor prognosis for tumors with p53 mutation.
authors: Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran;
authors: Annahita
authors: A
authors: Rezaie
authors: Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
authors: Abbas
authors: A
authors: Tavassoli
keywords: Dog; Immunohistochemistry; Subcutaneous Lymphoma; T cell; p53
references: Vet Pathol. 2003 May;40(3):237-48
references: 12724563
references: Vet Pathol. 2000 Jan;37(1):40-6
references: 10643979
references: J Comp Pathol. 2004 Aug-Oct;131(2-3):207-13
references: 15276860
references: Oncogene. 1998 Jan 15;16(2):249-55
references: 9464543
references: Br J Cancer. 2003 Oct 20;89(8):1530-7
references: 14562028
references: J Vet Med Sci. 2010 Aug;72(8):1067-9
references: 20234113
references: Vet Pathol. 1997 Sep;34(5):394-404
references: 9381650
references: Can Vet J. 2009 Apr;50(4):411-6
references: 19436451
references: Can Vet J. 2007 Sep;48(9):977-9
references: 17966344
references: Can Vet J. 2008 Mar;49(3):305-6, 308
references: 18390105