title: Non-invasive estimation of pulmonary artery pressures in patients with sickle cell anaemia in Ibadan, Nigeria: an echocardiographic study.
abstract: BACKGROUND
  Pulmonary hypertension is emerging as one of the causes of morbidity and mortality in adults with sickle cell disease. The prevalence of pulmonary hypertension in Nigerian adults with sickle cell anaemia is unknown. We decided to estimate the pulmonary artery systolic and diastolic pressures in subjects with sickle cell anaemia seen at the University College Hospital, Ibadan, Nigeria, and to determine the frequency of pulmonary hypertension among them.
  
  
  METHODS
  Ninety patients (38 males and 52 females) with sickle cell anaemia in steady state and comparable age- and sex-matched normal controls had a clinical evaluation and echocardiographic examination.
  
  
  RESULTS
  The mean age of the subjects with sickle cell anaemia was 24.0 (9.00) years while the mean age for the control group was 24.0 (7.00) years. The frequency of pulmonary hypertension as assessed by a tricuspid regurgitant jet velocity of > 2.5 m/s in this study was 12.2%. Larger left ventricular dimensions and volumes, higher stroke volume and increased left ventricular mass indexed by body surface area were found to be associated with pulmonary hypertension. A multivariate analysis of the potential predictors of pulmonary hypertension in this study showed that male sex and lower packed cell volume (PCV) were independent predictors of pulmonary hypertension in patients with sickle cell anaemia.
  
  
  CONCLUSIONS
  We conclude that pulmonary artery systolic and diastolic pressures are higher in subjects with sickle cell disease than normal controls. Male sex and low PCV are independent determinants of pulmonary arterial pressure in subjects with sickle cell anaemia in Nigeria.
authors: Evbu O
authors: EO
authors: Enakpene
authors: Adewole A
authors: AA
authors: Adebiyi
authors: Okechukwu S
authors: OS
authors: Ogah
authors: John A
authors: JA
authors: Olaniyi
authors: Akinyemi
authors: A
authors: Aje
authors: Moshood A
authors: MA
authors: Adeoye
authors: Ayodele O
authors: AO
authors: Falase
mesh_terms: D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging* / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D011669:Pulmonary Wedge Pressure; D012307:Risk Factors; D055815:Young Adult