title: If you lose your nerves, at least you will not get kidney fibrosis!
abstract: Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fibers are involved via norepinephrine and α2-adrenergic receptors as well as calcitonin gene-related peptide (CGRP) and its receptors.
authors: 1] Institute of Pathology and Department of Nephrology, RWTH University of Aachen, Aachen, Germany [2] Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.
authors: Peter
authors: P
authors: Boor
authors: 1] Institute of Pathology and Department of Nephrology, RWTH University of Aachen, Aachen, Germany [2] Department of Nephrology, University of Patras, Patras, Greece.
authors: Marios E
authors: ME
authors: Papasotiriou
mesh_terms: D000818:Animals; D003714:Denervation; D007668:Kidney / Q000098:blood supply* / Q000294:innervation*; D008297:Male; D015427:Reperfusion Injury / Q000517:prevention & control*