title: Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients.
abstract: OBJECTIVE
  To investigate the correlation among tumor markers, curative resection, and recurrence in gastric cancer.
  
  
  METHODS
  The patients with preoperative tumor makers [Carcinoembryonic antigen, Carbohydrate antigen (CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, retrospectively.
  
  
  RESULTS
  Among the 679 patients with gastric cancer, curative resection was 93.6% (n=636) and non-curative resection was 6.4% (n=43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level (HR=2.431, P=0.020), in a multivariate analysis.
  
  
  CONCLUSIONS
  Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients.
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Dae Hoon
authors: DH
authors: Kim
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Hyo Yung
authors: HY
authors: Yun
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Dong Hee
authors: DH
authors: Ryu
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Hye-Suk
authors: HS
authors: Han
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Joung-Ho
authors: JH
authors: Han
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Soon Man
authors: SM
authors: Yoon
authors: Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea.
authors: Sei Jin
authors: SJ
authors: Youn
mesh_terms: D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018394:CA-125 Antigen; D018395:CA-19-9 Antigen
keywords: Carbohydrate antigen 125; Carbohydrate antigen 19-9; Carcinoembryonic antigen; Gastric Cancer; Tumor Marker
references: Isr Med Assoc J. 2010 Dec;12(12):726-8
references: 21348398
references: Ann Surg Oncol. 2010 Jan;17(1):54-64
references: 19777193
references: Am J Clin Oncol. 1997 Aug;20(4):348-53
references: 9256887
references: Gastric Cancer. 2011 Jun;14(2):113-23
references: 21573742
references: Tumour Biol. 2001 Sep-Oct;22(5):318-22
references: 11553862
references: Ann Intern Med. 1986 Jan;104(1):66-73
references: 3510056
references: Ann Surg Oncol. 2013 Jul;20(7):2317-27
references: 23677605
references: Cancer. 1998 Dec 15;83(12):2488-92
references: 9874453
references: Acta Oncol. 1994;33(7):747-51
references: 7993641
references: J Clin Oncol. 2007 May 20;25(15):2107-16
references: 17513817
references: Ann Oncol. 1999;10 Suppl 4:145-9
references: 10436809
references: Hepatogastroenterology. 2002 Jul-Aug;49(46):1157-60
references: 12143226
references: BMC Gastroenterol. 2013;13:87
references: 23672279
references: Oncology. 1999 Jul;57(1):55-62
references: 10394126
references: N Engl J Med. 2008 Jul 31;359(5):453-62
references: 18669424
references: Cancer Control. 2011 Jan;18(1):16-21
references: 21273976
references: Chang Gung Med J. 2002 Dec;25(12):792-802
references: 12635835
references: Gastric Cancer. 2012 Sep;15 Suppl 1:S38-47
references: 21667136
references: Curr Opin Oncol. 1997 Jul;9(4):380-7
references: 9251889
references: Eur Radiol. 2000;10(12):1877-85
references: 11305564
references: Adv Ther. 2008 Oct;25(10):1075-84
references: 18821070
references: Anticancer Res. 1997 Jul-Aug;17(4B):2903-6
references: 9329559
references: World J Surg. 2010 May;34(5):1015-21
references: 20145923
references: Cancer Res Treat. 2004 Jun;36(3):178-81
references: 20396541
references: Scand J Gastroenterol. 1989 Aug;24(6):745-50
references: 2814339
references: J Surg Oncol. 2011 Nov 1;104(6):585-91
references: 21695697