title: Dissolution enhancement of curcumin via curcumin-prebiotic inulin nanoparticles.
abstract: Dissolution enhancement of curcumin via prebiotic inulin designed to orally deliver poorly water-soluble curcumin at duodenum low acidity (pH 5.5) was investigated. Different prebiotic inulin-curcumin nanoparticles were synthesized in ethanol-water binary system at different pre-adjusted pH values. Characterization via FTIR, XRD and TGA revealed the formation of curcumin-inulin conjugates, whereas surface morphology via SEM and TEM techniques implied the formation of nanoparticle beads and nanoclusters. Prebiotic inulin-curcumin nanoparticles prepared at pH 7.0 demonstrated a maximum curcumin dissolution enhancement of ≈90% with respect to 30% for curcumin alone at pH 5.5. Power law constant values were in accordance with dissolution enhancement investigations. All samples show Fickian diffusion mechanism. XRD investigations confirm that inulin maintain its crystalline structure in curcumin-inulin conjugate structure, which confirms that it can exert successfully its prebiotic role in the gastrointestinal (GI) tract. Therefore, the use of curcumin-inulin nanoparticles can perform dual-mission in the GI tract at the duodenum environment; release of 90% of curcumin followed by prebiotic activity of inulin, which will probably play a significant role in cancer therapeutics for the coming generations.
authors: a Department of Chemical Science, Faculty of Science & Arts , Jordan University of Science and Technology , Irbid , Jordan and.
authors: Mohammad M
authors: MM
authors: Fares
authors: b Faculty of Pharmacy , The Royal University for Medical Sciences , Amman , Jordan.
authors: Mu'taz Sheikh
authors: MS
authors: Salem
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems; D065546:Drug Liberation; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007444:Inulin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D056692:Prebiotics; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D056692:Prebiotics; D014867:Water; D007444:Inulin; D003474:Curcumin
keywords: Curcumin; curcumin–inulin nanoparticles; dissolution enhancement; prebiotic inulin