title: Multiphase arterial spin labeling assessment of cerebral perfusion changes associated with middle cerebral artery stenosis.
abstract: OBJECTIVE
  To assess the sensitivity and utility of multiphase pulsed arterial spin labeling (PASL) in detecting dynamic changes of cerebral perfusion in the presence of a middle cerebral artery (MCA) severe stenosis.
  
  
  METHODS
  Seventeen patients with severe stenoses in unilateral M1 segment of MCA were involved in this study. All patients underwent multiphase PASL imaging. Bilateral basal ganglia were drawn by hand as regions of interest (ROIs) on eight-phase images of each patient. The signal intensities of ROIs were measured and the time-intensity curves (TICs) were acquired through postprocessing on a magnetic resonance workstation. Whether there was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides was determined by the paired samples t test.
  
  
  RESULTS
  Three types of TICs were observed: eight cases with platform type, five cases with two-peak type, and four cases with single-peak type. There was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides.
  
  
  CONCLUSIONS
  Different types of TICs represent different cerebral hemodynamic changes. Multiphase PASL can sensitively detect the dynamic characteristics of cerebral perfusion and provide important dynamic perfusion information for clinical treatment of arterial stenosis.
authors: Shandong Medical Imaging Research Institute, Shandong University, Jingwu Rd No. 324, Jinan, Shandong Province 250021, China; Department of Radiology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China.
authors: Jun
authors: J
authors: Chen
authors: Shandong Medical Imaging Research Institute, Shandong University, Jingwu Rd No. 324, Jinan, Shandong Province 250021, China. Electronic address: sdmuyxs@sina.com.
authors: Bin
authors: B
authors: Zhao
authors: Department of Radiology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China.
authors: Min
authors: M
authors: Bai
authors: Department of Radiology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China.
authors: Chunqing
authors: C
authors: Bu
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D002533:Cerebral Angiography / Q000379:methods*; D003251:Constriction, Pathologic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Multiphase PASL; cerebral perfusion changes; middle cerebral artery stenosis