title: [Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population].
abstract: OBJECTIVE
  To investigate association between the lysyl oxidase-like 1 (LOXL1) gene single nucleotide polymorphism (SNP) and primary open-angle glaucoma (POAG) in Sichuan population.
  
  
  METHODS
  In this study,416 subjects with primary open-angle glaucoma and 997 normal controls were recruited.Three reported LOXL1 tag SNPs (rs1048661,rs3825942 and rs2165241) were genotyped by SNaPshot method.
  
  
  RESULTS
  The study showed that the genotypes of LOXL1 rs1048661,rs3825942 and rs2165241 between POAG and control groups were not statistically significant (OR=1.085, 95%CI 0.92-1.28, P=0.578 for rs1048661; OR=1.059, 95%CI 0.82-1.37, P=0.846 for rs3825942; OR=1.006, 95%CI 0.77-1.32, P=0.966 for rs2165241, respectively). There were no significant difference in allele frequency distribution of LOXL1 rs1048661、rs3825942 and rs2165241 between POAG and normal controls (P=0.322, P=0.660, P=0.965).
  
  
  CONCLUSIONS
  The results from the present study do not indicate the association of LOXL1 SNPs (rs1048661, rs3825942 and rs2165241) with POAG in Sichuan population.
authors: Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610000, P. R. China. Email: zdd25@sina.com.
authors: Bo
authors: B
authors: Gong
authors: Xiulan
authors: X
authors: Li
authors: Ning
authors: N
authors: Li
authors: Fang
authors: F
authors: Hao
authors: Rong
authors: R
authors: Chen
authors: Guangqun
authors: G
authors: Zeng
authors: Dingding
authors: D
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human