title: Micro- and nano-structure based oligonucleotide sensors.
abstract: This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporated into hand-held devices and their suitability for mass production means that, out of the different approaches to oligonucleotide detection, they are the most suitable for commercialisation. This review discusses the advantages of micro- and nano-structure based sensors and covers the various oligonucleotide detection techniques that have been developed to date. These include: Bulk Acoustic Wave and Surface Acoustic Wave devices, micro- and nano-cantilever sensors, gene Field Effect Transistors, and nanowire and nanopore based sensors. Oligonucleotide immobilisation techniques are also discussed.
authors: School of Engineering, University of Edinburgh, Edinburgh EH9 3JL, UK.
authors: David C
authors: DC
authors: Ferrier
authors: School of Chemistry, David Brewster Road, University of Edinburgh, Edinburgh EH9 3FJ, UK.
authors: Michael P
authors: MP
authors: Shaver
authors: School of Engineering, University of Edinburgh, Edinburgh EH9 3JL, UK. Electronic address: philip.hands@ed.ac.uk.
authors: Philip J W
authors: PJW
authors: Hands
mesh_terms: D015374:Biosensing Techniques; D049329:Nanostructures / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides
keywords: Biosensor; DNA; Detection; MEMS; NEMS; Oligonucleotide