title: Can circulating tumor cells predict resistance in metastatic breast cancer?
abstract: Circulating tumor cell (CTC) enumeration provides prognostic but not predictive information for chemotherapy in metastatic breast cancer. Because CTC measurement is reproducible and allows molecular profiling, an assay to assess endocrine resistance was developed. Whether this CTC-based assay can be used to reliably select endocrine therapy must be tested.
authors: Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, Pennsylvania.
authors: Aju
authors: A
authors: Mathew
authors: Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, Pennsylvania.
authors: Adam M
authors: AM
authors: Brufsky
authors: Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, Pennsylvania. davidsonne@upmc.edu.
authors: Nancy E
authors: NE
authors: Davidson
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*
chemical_list: D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen
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