title: Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction.
abstract: The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion, and monitored the effect of 25 μg/kg leukemia inhibitory factor and (or) basic fibroblast growth factor administration 2 hours after model establishment. Results showed that following administration, the number of endogenous neural stem cells in the infarct area significantly increased, malondialdehyde content in brain tissue homogenates significantly decreased, nitric oxide content, glutathione peroxidase and superoxide dismutase activity significantly elevated, and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests. In particular, the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant. Results indicate that leukemia inhibitory factor and basic fibroblast growth factor can improve the microenvironment after cerebral infarction by altering free radical levels, improving the quantity of endogenous neural stem cells, and promoting neurological function of mice with cerebral infarction.
authors: Department of Neurology, Tianjin First Center Hospital, Tianjin Medical University, Tianjin 300192, China.
authors: Weihui
authors: W
authors: Huang
authors: Department of Neurology, Tianjin First Center Hospital, Tianjin Medical University, Tianjin 300192, China.
authors: Yadan
authors: Y
authors: Li
authors: Department of Neurology, Tianjin First Center Hospital, Tianjin Medical University, Tianjin 300192, China.
authors: Yufeng
authors: Y
authors: Lin
authors: Department of Neurology, Tianjin First Center Hospital, Tianjin Medical University, Tianjin 300192, China.
authors: Xue
authors: X
authors: Ye
authors: Department of Neurology, Tianjin First Center Hospital, Tianjin Medical University, Tianjin 300192, China.
authors: Dawei
authors: D
authors: Zang
keywords: basic fibroblast growth factor; endogenous neural stem cells; free radical; glutathione peroxidase; leukemia inhibitory factor; malondialdehyde; neuroprotection; nitric oxide; superoxide dismutase
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