title: Effects of synbiotics on treatment of children with failure to thrive: A triple blind placebo-controlled trial.
abstract: BACKGROUND
  Failure to thrive (FTT) is a common problem of children especially in underdeveloped countries. In addition to its short-term adverse health effects, it is associated with long-term behavioral and cognitive defects. One of the recommended treatment modalities for FTT is using synbiotics. Due to high prevalence of FTT with undefined organic causes and failure of most medications on treatment of this type of FTT, we decided to search the effect of synbiotics on these patients.
  
  
  METHODS
  A randomized, triple-blinded, placebo-controlled trial study was done from 2011 to 2012. A number of 84 patients were randomly assigned to intervention and control groups. The synbiotics sachets were administered to study group for 6 months. The growth indices were measured at the beginning of the trial after 3 and 6 months, and compared with control.
  
  
  RESULTS
  Variance analysis of observations showed improvement of growth indices in both groups. The increase in weight was significantly higher in synbiotics group than in controls (P < 0.05). The corresponding figure was not significant for height and head circumference (P > 0.05). At the beginning of the trial, the mean weights were 10.25 ± 0.20 kg and 10.750 ± 0.160 kg in intervention and control groups, respectively, Meanwhile, after 6 months, the mean weights of two groups became 12.280 ± 0.190 and 11.760 ± 0.17 kg in intervention and control groups, respectively. This result has confirmed that the effect of synbiotics is significant on weight gain of our patients.
  
  
  CONCLUSIONS
  Our findings support beneficial effects of synbiotics in weight gain of children with FTT.
authors: Department of Pediatrics, Shahrekord University of Medical Science, Shahrekord, Iran ; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan, Iran.
authors: Fatemeh
authors: F
authors: Famouri
authors: Department of Pediatrics, Shahrekord University of Medical Science, Shahrekord, Iran.
authors: Abolfazl
authors: A
authors: Khoshdel
authors: Department of Pediatrics, Shahrekord University of Medical Science, Shahrekord, Iran.
authors: Arghavan
authors: A
authors: Golshani
authors: Department of Statistical Sciences, Shahrekord University of Medical Science, Shahrekord, Iran.
authors: Soleiman
authors: S
authors: Kheiri
authors: Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan, Iran ; Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Hossein
authors: H
authors: Saneian
authors: Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan, Iran ; Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Roya
authors: R
authors: Kelishadi
keywords: Children; failure to thrive; growth; synbiotics
references: Asia Pac J Clin Nutr. 2011;20(1):69-76
references: 21393113
references: Nutrition. 2002 May;18(5):393-6
references: 11985943
references: Biomed Environ Sci. 2005 Jun;18(3):192-7
references: 16131023
references: Indian J Med Microbiol. 2009 Jul-Sep;27(3):202-9
references: 19584499
references: Pediatrics. 2007 Jul;120(1):59-69
references: 17606562
references: J Appl Microbiol. 2006 Jun;100(6):1171-85
references: 16696665
references: Clin Pediatr (Phila). 2006 Jan-Feb;45(1):1-6
references: 16429209
references: Arch Dis Child. 2007 Feb;92(2):109-14
references: 16531456
references: Int J Food Sci Nutr. 2013 Sep;64(6):687-93
references: 23477506
references: IDrugs. 2003 Jun;6(6):573-80
references: 12811680
references: Br J Nutr. 2009 Sep;102(6):869-75
references: 19331702
references: J Am Coll Nutr. 2006 Oct;25(5):415-9
references: 17031011
references: Pediatrics. 2004 Jun;113(6):e617-27
references: 15173545
references: Am J Clin Nutr. 2008 May;87(5):1365-73
references: 18469260
references: Pediatr Rev. 2006 Jan;27(1):e1-11
references: 16403734
references: Crit Care. 2012 Jun 25;16(3):R109
references: 22731894
references: Br J Nutr. 2009 Jun;101(11):1722-6
references: 18986600
references: Lancet. 2009 Jul 11;374(9684):136-44
references: 19595348
references: J Res Med Sci. 2013 Feb;18(2):85-8
references: 23914206
references: J Hum Nutr Diet. 2006 Feb;19(1):51-8
references: 16448475
references: Vaccine. 2009 Feb 11;27(7):1073-9
references: 19114073