title: Progression-seeking bias and rational optimism in research and development.
authors: Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.
authors: Dennis W
authors: DW
authors: Lendrem
authors: Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.
authors: B Clare
authors: BC
authors: Lendrem
authors: Roche Innovation Centre, Welwyn, AL7 1TW, UK.
authors: Richard W
authors: RW
authors: Peck
authors: CRP-Santé, Strassen L-1445, Luxembourg.
authors: Stephen C
authors: SC
authors: Senn
authors: Clinical Trials Consulting &Training Ltd, North Marston, MK18 3PL, UK.
authors: Simon
authors: S
authors: Day
authors: Institute of Cellular Medicine, Newcastle University, Newcastle, NE2 4HH, UK.
authors: John D
authors: JD
authors: Isaacs
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000191:economics / Q000706:statistics & numerical data / Q000639:trends*; D015195:Drug Design; D004345:Drug Industry / Q000191:economics / Q000706:statistics & numerical data / Q000639:trends; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D010600:Pharmacology / Q000191:economics / Q000706:statistics & numerical data / Q000639:trends*
references: Mol Cell Biol. 2011 Jul;31(14):3029-37
references: 21576370
references: Nat Rev Drug Discov. 2014 Sep;13(9):673-91
references: 25131830