title: Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance
abstract: The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.
authors: L I
authors: LI
authors: Shuaizhang
authors: Wen
authors: W
authors: Zhang
authors: Xuejiao
authors: X
authors: Yin
authors: Shilai
authors: S
authors: Xing
authors: Qunhui
authors: Q
authors: Xie
authors: State Key Laboratory of Natural Medicines and Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, P.R. China, 211198. zycao1999@hotmail.com.
authors: Zhengyu
authors: Z
authors: Cao
authors: Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. binzhao@rcees.ac.cn.
authors: Bin
authors: B
authors: Zhao