title: Design of a homogeneous multifunctional supported lipid membrane on layer-by-layer coated microcarriers.
abstract: Key challenges in the development of drug delivery systems are the prevention of serum compartment interaction and the targeted delivery of the cargo. Layer-by-Layer microcarriers offer many advantages due to various options in drug assembly and multifunctional design. Surface modification with a supported lipid membrane enhances biocompatibility, drug protection ability, and specific functionality. However, the integration of functionalized lipids strongly influences the membrane formation and is often accompanied by submicrometer irregularities: The accessibility of underlying polymers to serum components may change the carrier's properties and enhances the susceptibility to opsonization. Therefore, the formation of a tightly assembled multifunctional lipid membrane has been emphasized. A phosphatidylserine/phosphatidylcholine (POPS/POPC) bilayer equipped with phosphatidylethanolamine-polyethylene glycol-biotin (PE-PEG-Biotin) was used to facilitate a biotin/streptavidin binding site for a variable attachment of an additional function, such as antibodies for specific targeting. Thus, a prefunctionalized carrier where only the outer functionality needs to be replaced without disturbing the underlying structure could be created.
authors: Institute for Medical Physics and Biophysics, Faculty of Medicine, University of Leipzig , 04107 Leipzig, Germany.
authors: Martin
authors: M
authors: Göse
authors: Paula
authors: P
authors: Pescador
authors: Uta
authors: U
authors: Reibetanz
mesh_terms: D001710:Biotin / Q000737:chemistry; D004337:Drug Carriers; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D010718:Phosphatidylserines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D011092:Polyethylene Glycols; C050294:1-palmitoyl-2-oleoylglycero-3-phosphoserine; D001710:Biotin; D012822:Silicon Dioxide; D019809:Streptavidin; C028694:1-palmitoyl-2-oleoylphosphatidylcholine