title: Cinnarizine versus Topiramate in Prophylaxis of Migraines among Children and Adolescents: A Randomized, Double-Blind Clinical Trial.
abstract: OBJECTIVE
  Migraines, a common health problem in children and adolescents, still do not have an FDA approved preventive treatment for patients under the age of 18 years. This study compares and contrasts the efficacy and safety of cinnarizine and topiramate in preventing pediatric migraines.
  
  
  METHODS
  In this randomized, double-blind clinical trial 44 migrainous (from 4-15 years of age) were equally allocated to receive cinnarizine or topiramate. The primary efficacy measure was monthly migraine frequency. Secondary efficacy measures were monthly migraine intensity and ≥ 50% responder rate. Efficacy measures were recorded at the baseline and at 4, 8, and 12 weeks of treatment.
  
  
  RESULTS
  During the double-blind phase of the study, monthly migraine frequency and intensity were significantly decreased in both the cinnarizine and topiramate groups when compared to the baseline. However, at the end of the study, the cinnarizine group exhibits a significant decrease from the baseline in the mean monthly migraine intensity when compared to the topiramate group (4.7 vs. 3, respectively; 95% CI = -0.8 to -3.2).
  
  
  CONCLUSIONS
  No significant difference between cinnarizine and topiramate was found for the prevention of pediatric migraines. Both treatments were well tolerated.
authors: Pediatrics Centre of Excellence, Department of Pediatric Neurology, Children's Medical Centre, Tehran University of Medical Sciences, Tehran, Iran ; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Ira.
authors: Mahmoud Reza
authors: MR
authors: Ashrafi
authors: Pediatrics Centre of Excellence, Department of Pediatric Neurology, Children's Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.
authors: Zeinab
authors: Z
authors: Najafi
authors: Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Masih
authors: M
authors: Shafiei
authors: Department of epidemiology and biostatistics, School of Public Health, Tehran University of medical sciences, Tehran, Iran.
authors: Kazem
authors: K
authors: Heidari
authors: Iranian Centre of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran ; Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mansoureh
authors: M
authors: Togha
keywords: Cinnarizine; Migraine; Pediatrics; Topiramate
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