title: Contemporary evidence on the physiological role of reactive oxygen species in human sperm function.
abstract: Reactive oxygen species (ROS) play an important role in male fertility. Overproduction of reactive oxygen species (ROS) has been associated with a variety of male fertility complications, including leukocytospermia, varicocele and idiopathic infertility. The subsequent oxidative insult to spermatozoa can manifest as insufficient energy metabolism, lipid peroxidation and DNA damage, leading to loss of motility and viability. However, various studies have demonstrated that physiological amounts of ROS play important roles in the processes of spermatozoa maturation, capacitation, hyperactivation and acrosome reaction. It is therefore crucial to define and understand the delicate oxidative balance in male reproductive cells and tissues for a better understanding of both positive as well as negative impact of ROS production on the fertilizing ability. This review will discuss the specific physiological roles, mechanisms of action and effects that ROS have on the acquisition of structural integrity and physiological activity of spermatozoa.
authors: Center for Reproductive Medicine, Cleveland Clinic, 10681 Carnegie Avenue, Mail Code X-11, Cleveland, OH, 44195, USA, ssdp@sun.ac.za.
authors: Stefan S
authors: SS
authors: Du Plessis
authors: Ashok
authors: A
authors: Agarwal
authors: Jacques
authors: J
authors: Halabi
authors: Eva
authors: E
authors: Tvrda
mesh_terms: D006801:Humans; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013094:Spermatozoa / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species
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