title: Hypertensive epigenetics: from DNA methylation to microRNAs.
abstract: The major epigenetic features of mammalian cells include DNA methylation, posttranslational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (microRNAs (miRNAs)). An important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced by nutritional-environmental factors and through gene-environment interactions. Studies on epigenetic modulations could help us understand the mechanisms involved in essential hypertension and further prevent it's progress. This review is focused on new knowledge on the role of epigenetics, from DNA methylation to miRNAs, in essential hypertension.
authors: State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: J
authors: J
authors: Wang
authors: State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: L
authors: L
authors: Gong
authors: State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Y
authors: Y
authors: Tan
authors: State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: R
authors: R
authors: Hui
authors: State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Y
authors: Y
authors: Wang
mesh_terms: D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
references: Curr Hypertens Rep. 1999 Feb-Mar;1(1):42-50
references: 10981041
references: Indian J Biochem Biophys. 2011 Oct;48(5):301-7
references: 22165287
references: Lancet. 2005 Jan 15-21;365(9455):217-23
references: 15652604
references: Pulm Pharmacol Ther. 2013 Feb;26(1):75-85
references: 22800879
references: Hypertension. 2004 Apr;43(4):854-9
references: 14769811
references: Curr Hypertens Rep. 2011 Feb;13(1):21-8
references: 21125351
references: Eur Heart J. 2013 Jul;34(28):2159-219
references: 23771844
references: Exp Cell Res. 2011 Nov 1;317(18):2555-61
references: 21925168
references: Cell. 2007 Feb 23;128(4):635-8
references: 17320500
references: Expert Opin Ther Targets. 2013 Mar;17(3):217-23
references: 23339529
references: Curr Opin Nephrol Hypertens. 2006 Sep;15(5):517-23
references: 16914965
references: J Cell Biol. 2007 Jan 1;176(1):89-100
references: 17190791
references: Hypertension. 1995 Mar;25(3):320-6
references: 7875756
references: Cell. 2005 Jan 14;120(1):15-20
references: 15652477
references: J Am Soc Nephrol. 2008 Oct;19(10):1845-54
references: 18753254
references: Biochem Biophys Res Commun. 2010 May 28;396(2):252-7
references: 20406621
references: J Mol Cell Cardiol. 2014 Oct;75:25-39
references: 24976017
references: Mol Aspects Med. 2013 Jul-Aug;34(4):883-901
references: 22981780
references: FEBS Lett. 1998 Jun 23;430(1-2):41-4
references: 9678591
references: Prog Biophys Mol Biol. 2000;74(3-5):175-221
references: 11226512
references: J Pineal Res. 2008 Oct;45(3):277-84
references: 18373554
references: Curr Hypertens Rep. 2010 Feb;12(1):17-25
references: 20425154
references: Am J Physiol. 1998 Jun;274(6 Pt 1):C1699-707
references: 9611136
references: Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14879-84
references: 18812516
references: Med Hypotheses. 2006;66(5):1000-7
references: 16434146
references: Ann Clin Lab Sci. 2009 Summer;39(3):241-50
references: 19667408
references: J Cardiovasc Pharmacol. 1996 Dec;28(6):746-54
references: 8961071
references: J Cell Physiol. 2007 Nov;213(2):384-90
references: 17708532
references: Physiol Res. 2009;58 Suppl 2:S33-41
references: 20131935
references: Mol Cell Biol. 1990 Aug;10(8):4294-302
references: 2164636
references: Int J Mol Sci. 2013 May 27;14(6):11190-207
references: 23712358
references: Dev Cell. 2008 Aug;15(2):272-84
references: 18694566
references: Nat Rev Genet. 2010 Apr;11(4):285-96
references: 20300089
references: Nat Rev Cardiol. 2010 Sep;7(9):510-9
references: 20603647
references: Curr Opin Nephrol Hypertens. 2004 Jul;13(4):451-8
references: 15199296
references: Endocrine. 2010 Feb;37(1):106-14
references: 19882252
references: Nat Rev Genet. 2011 Nov 18;12(12):861-74
references: 22094949
references: Mol Cell Pharmacol. 2011;3(3):83-92
references: 22468167
references: Kidney Int. 2009 Feb;75(3):260-7
references: 18818687
references: Atherosclerosis. 2008 Aug;199(2):323-7
references: 18178212
references: Am J Hypertens. 2005 Aug;18(8):1091-8
references: 16109323
references: J Am Soc Nephrol. 2010 Nov;21(11):1942-51
references: 20947633
references: Genome Res. 2004 Oct;14(10A):1902-10
references: 15364901
references: Biochim Biophys Acta. 2010 Dec;1802(12):1178-87
references: 19909806
references: Nature. 2009 Jan 22;457(7228):405-12
references: 19158786
references: Cell Mol Life Sci. 2000 Jun;57(6):884-95
references: 10950304
references: J Am Soc Hypertens. 2014 Jun;8(6):368-75
references: 24794206
references: PLoS One. 2013 May 15;8(5):e63455
references: 23691048
references: Can J Cardiol. 2013 Jan;29(1):46-57
references: 23261320
references: Circulation. 2000 Feb 15;101(6):682-8
references: 10673262
references: Int J Biochem Cell Biol. 2009 Apr;41(4):872-8
references: 18793746
references: Curr Opin Nephrol Hypertens. 2010 Mar;19(2):163-8
references: 20061948
references: Mol Biol Rep. 2013 Jun;40(6):4047-53
references: 23271137
references: Cell. 2004 Jan 23;116(2):281-97
references: 14744438
references: J Biol Chem. 2010 Apr 16;285(16):11903-12
references: 20177053
references: JAMA. 2002 Oct 16;288(15):1882-8
references: 12377087
references: Hypertension. 2011 Dec;58(6):1093-8
references: 22042811
references: Pflugers Arch. 2004 Oct;449(1):42-55
references: 15293051
references: Curr Hypertens Rep. 2012 Feb;14 (1):79-87
references: 22052337
references: J Clin Invest. 2007 Mar;117(3):773-83
references: 17332896
references: Endocrinology. 2009 May;150(5):2202-10
references: 19106216
references: Mol Biol Rep. 2013 Jun;40(6):4055-63
references: 23588958
references: Nat Med. 2011 May;17(5):573-80
references: 21499270
references: J Cell Sci. 2008 Oct 15;121(Pt 20):3293-304
references: 18843116
references: Am J Physiol Renal Physiol. 2009 Sep;297(3):F553-8
references: 19339633
references: Physiol Genomics. 2013 Oct 1;45(19):901-6
references: 23943853
references: Heart Lung Circ. 2014 Jun;23(6):503-10
references: 24726001
references: JAMA. 2014 Feb 5;311(5):507-20
references: 24352797
references: Physiol Rev. 2005 Apr;85(2):423-93
references: 15788703
references: Nat Genet. 2003 Dec;35(4):372-6
references: 14608358
references: Epigenetics. 2011 Apr;6(4):478-89
references: 21364323
references: PLoS One. 2014 Aug 29;9(8):e106138
references: 25170764
references: J Clin Invest. 1996 Jun 15;97(12):2815-22
references: 8675693
references: J Hypertens. 1999 Nov;17(11):1577-82
references: 10608471
references: Hypertension. 2011 Sep;58(3):439-45
references: 21768522
references: Biochem J. 2006 Jul 1;397(1):223-31
references: 16669787
references: Curr Opin Nephrol Hypertens. 2004 Sep;13(5):541-8
references: 15300161
references: Ann Intern Med. 2003 Nov 4;139(9):761-76
references: 14597461
references: Przegl Lek. 2003;60(10):657-62
references: 15052729
references: J Biol Chem. 2006 Jun 30;281(26):18059-68
references: 16636056
references: J Cell Biochem. 2009 Sep 1;108(1):43-51
references: 19565567
references: J Hypertens. 1998 Dec;16(12 Pt 2):2063-74
references: 9886898
references: J Clin Invest. 2004 Oct;114(8):1146-57
references: 15489962
references: Int J Biochem Cell Biol. 2010 Sep;42(9):1536-43
references: 20561597
references: Am J Physiol Renal Physiol. 2013 Oct 1;305(7):F1006-13
references: 23926181
references: Chem Biol. 2008 Nov 24;15(11):1166-74
references: 19022177
references: Am J Hypertens. 2011 Dec;24(12):1286-93
references: 21814290
references: J Biol Chem. 2009 Dec 18;284(51):35659-69
references: 19864429
references: J Biol Chem. 2005 Dec 30;280(52):42685-93
references: 16263722