title: Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP.
abstract: Successful clearance of hepatitis B virus (HBV) is a promising event in which host's immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this review the impact of host immune response in declining HBsAg during the natural history of the infection has been discussed.
authors: 1. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Ashraf
authors: A
authors: Mohamadkhani
authors: 1. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Aezam
authors: A
authors: Katoonizadeh
authors: 1. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Hossein
authors: H
authors: Poustchi
keywords: Chronic hepatitis B; Human leukocyte antigens DP (HLA-DP ); Immune response; Polymorphism
references: Hepat Mon. 2012 Sep;12(9):e6618
references: 23087764
references: Arab J Gastroenterol. 2012 Dec;13(4):170-3
references: 23432984
references: J Gen Virol. 2000 Jan;81(Pt 1):67-74
references: 10640543
references: Virology. 1988 Jul;165(1):172-81
references: 3388768
references: J Gen Virol. 2002 Aug;83(Pt 8):2059-73
references: 12124470
references: Hepatology. 2004 Jun;39(6):1694-701
references: 15185311
references: N Engl J Med. 1995 Apr 20;332(16):1065-9
references: 7898524
references: J Biomed Biotechnol. 2011;2011:298348
references: 21629750
references: Hepatology. 2012 May;55(5):1426-31
references: 22105689
references: Gastroenterology. 2011 Aug;141(2):517-25, 525.e1-2
references: 21672542
references: Rev Immunogenet. 1999;1(1):105-23
references: 11256568
references: World J Gastroenterol. 2007 Mar 28;13(12):1770-87
references: 17465466
references: IEEE/ACM Trans Comput Biol Bioinform. 2013 May-Jun;10(3):811-5
references: 24091413
references: J Virol. 2000 Feb;74(3):1495-505
references: 10627561
references: Biol Cell. 2009 May;101(5):251-62
references: 19275763
references: J Med Virol. 2012 Dec;84(12):1889-96
references: 23080492
references: J Viral Hepat. 2007 Dec;14(12):841-8
references: 18070287
references: J Exp Med. 2000 Apr 17;191(8):1269-80
references: 10770795
references: Virol J. 2009 Nov 26;6:209
references: 19939285
references: Medscape J Med. 2008 Apr 16;10(4):91
references: 18504503
references: Zhonghua Gan Zang Bing Za Zhi. 2011 Jan;19(1):38-43
references: 21272457
references: Hepatology. 2000 Feb;31(2):480-7
references: 10655274
references: Gastroenterology. 2010 Aug;139(2):483-90
references: 20451520
references: J Gen Virol. 1988 Oct;69 ( Pt 10):2575-83
references: 3171552
references: Nat Struct Mol Biol. 2010 Feb;17(2):222-9
references: 20062055
references: J Viral Hepat. 2005 Sep;12(5):488-93
references: 16108763
references: Gastroenterology. 2012 Dec;143(6):1586-1596.e8
references: 22960656
references: Virus Res. 2012 Jan;163(1):328-33
references: 22056847
references: Immunology. 2003 Aug;109(4):487-95
references: 12871214
references: J Virol. 2008 Jul;82(13):6585-90
references: 18434399
references: Nat Med. 2012 Jul;18(7):1060-8
references: 22706385
references: World J Gastroenterol. 2012 Jun 28;18(24):3119-28
references: 22791948
references: Infect Genet Evol. 2012 Aug;12(6):1222-8
references: 22543033
references: Adv Virol. 2013;2013:780319
references: 24187552
references: J Virol. 2012 Jun;86(12):6979-85
references: 22496224
references: Semin Liver Dis. 2003 Nov;23(4):385-96
references: 14722815
references: J Hepatol. 1991 Mar;12(2):203-6
references: 2050998
references: J Med Virol. 2006 May;78(5):561-8
references: 16555293
references: PLoS One. 2012;7(6):e39175
references: 22737229
references: Hepatology. 1995 Jul;22(1):61-8
references: 7601434
references: Tissue Antigens. 2012 Mar;79(3):165-73
references: 22224408
references: Semin Liver Dis. 2003 Feb;23(1):5-20
references: 12616447
references: Virology. 1994 Feb;198(2):489-503
references: 8291231
references: J Exp Med. 2000 Oct 2;192(7):921-30
references: 11015434
references: Middle East J Dig Dis. 2010 Jan;2(1):31-41
references: 25197510
references: J Gen Virol. 2006 Jun;87(Pt 6):1439-49
references: 16690908
references: J Virol. 2000 Jun;74(12):5502-8
references: 10823855
references: J Viral Hepat. 2008 Oct;15(10):753-60
references: 18507754
references: Genes Immun. 2011 Sep;12(6):428-33
references: 21346778
references: Gastroenterology. 2002 Dec;123(6):1848-56
references: 12454842
references: Hepatology. 2009 Apr;49(4):1141-50
references: 19338056
references: J Exp Med. 2011 Nov 21;208(12):2367-74
references: 22084408
references: J Gen Virol. 1999 Jul;80 ( Pt 7):1769-76
references: 10423146