title: Enantiomerically pure 3-aryl- and 3-hetaryl-2-hydroxypropanoic acids by chemoenzymatic reduction of 2-oxo acids.
abstract: Phenyllactic acids are found in numerous natural products as well as in active substances used in medicine or plant protection. Enantiomerically pure phenyllactic acids are available by transition-metal-catalyzed hydrogenations or chemoenzymatic reductions of the corresponding 3-aryl-2-oxopropanoic acids. We show here that d-lactate dehydrogenase from Staphylococcus epidermidis reduces a broad spectrum of 2-oxo acids, which are difficult substrates for transition-metal-catalyzed reactions, with excellent enantioselectivities in a simple experimental setup.
authors: Faculty of Mathematics and Natural Sciences, Bergische Universität Wuppertal , Gaußstraße 20, D-42119 Wuppertal, Germany.
authors: Sivatharushan
authors: S
authors: Sivanathan
authors: Florian
authors: F
authors: Körber
authors: Jannis Aron
authors: JA
authors: Tent
authors: Svenja
authors: S
authors: Werner
authors: Jürgen
authors: J
authors: Scherkenbeck
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D045022:Lactate Dehydrogenases / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*; D013210:Staphylococcus / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D011422:Propionates; D028561:Transition Elements; D045022:Lactate Dehydrogenases; C071195:D-lactate dehydrogenase