title: Endocrine tumours: familial nonmedullary thyroid carcinoma is a more aggressive disease: a systematic review and meta-analysis.
abstract: OBJECTIVE
  There is controversy as to whether familial nonmedullary thyroid carcinoma (FNMTC) is more aggressive than sporadic NMTC (SNMTC). The aim of the study was to evaluate the biological characteristics of patients with FNMTC by a meta-analysis.
  
  
  METHODS
  Four databases (PubMed, EMBASE, the Cochrane library databases, and the Web of Science) were searched to identify studies published before September, 2014. All original studies that compared clinical characteristics and prognosis of patients with FNMTC and SNMTC were included. The pooled effect sizes of interesting parameters were calculated by odds ratio (OR), standard mean difference (SMD), or hazard ratio (HR).
  
  
  RESULTS
  Twelve studies with a total of 12 741 participants were included in this analysis. FNMTC patients had an increased rate of recurrence (OR=1.72, 95% CI: 1.34 to 2.20) and decreased disease-free survival (DFS) (HR=1.83, 95% CI: 1.34 to 2.52) in comparison with SNMTC patients. FNMTC possessed more aggressive biological behaviors, characterized by younger age at diagnosis (SMD=-0.91, 95% CI: -1.59 to -0.22), higher risk of multifocal (OR=1.50, 95% CI: 1.32 to 1.71), bilateral (OR=1.29, 95% CI: 1.00 to 1.66), extrathyroidal invasion (OR=1.20, 95% CI: 1.02 to 1.41), and lymph node metastasis (OR=1.18, 95% CI: 1.01 to 1.38).
  
  
  CONCLUSIONS
  FNMTC is a more aggressive disease and possesses higher recurrence rate and lower DFS. More attention and careful consideration should be paid regarding the decision about treatment for patients with FNMTC.
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Xiaofei
authors: X
authors: Wang
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Wenli
authors: W
authors: Cheng
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Jingdong
authors: J
authors: Li
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Anping
authors: A
authors: Su
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Tao
authors: T
authors: Wei
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors: Feng
authors: F
authors: Liu
authors: Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China westchinaz@sohu.com.
authors: Jingqiang
authors: J
authors: Zhu
mesh_terms: D002277:Carcinoma / Q000401:mortality / Q000473:pathology*; D002291:Carcinoma, Papillary; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology*