title: Cardiovascular, metabolic, and coronary dysfunction in high-fat-fed obesity-resistant/prone rats.
abstract: OBJECTIVE
  Obesity is a global epidemic leading to several comorbidities including diabetes and cardiovascular disease. The hypothesis that the genetic background of the obesity-prone rat (OP) predisposes to physiologic, metabolic, and microvascular dysfunction which is exacerbated by a diet high in saturated fats was tested.
  
  
  METHODS
  Male OP and obesity-resistant (OR) rats were fed either a diet containing 10% (chow) or 45% kcal fat (HF) for 42 weeks.
  
  
  RESULTS
  Weight of OP rats was greater than OR rats by 8 weeks on both diets. Blood pressure was increased in OP rats on chow and further augmented by HF diet compared to OR rats on similar diets. In contrast to weight and blood pressure, glucose clearance was similar in OR and OP rats on chow and impaired in both models on HF diet. Relaxation to acetylcholine was attenuated in OP rats compared to OR rats by 8 weeks and remained reduced throughout the study. A longer period of time was required to observe vascular dysfunction in HF-fed OR rats.
  
  
  CONCLUSIONS
  When compared to OR rats, OP rats are prone to develop not only greater obesity but also hypertension and vascular dysfunction on a normal diet which is further augmented with HF diet.
authors: Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa and the Iowa City Veterans Affairs Health Care System, Iowa City, Iowa, USA.
authors: Brian L
authors: BL
authors: Dake
authors: Christine L
authors: CL
authors: Oltman
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology*; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000494:pharmacology; D004198:Disease Susceptibility; D002149:Energy Intake; D018149:Glucose Intolerance / Q000209:etiology / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats