title: Insulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome.
abstract: OBJECTIVE
  To assess whether birth weight influences the metabolic and hormonal profile of adolescents with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University outpatient clinic.
  
  
  METHODS
  One hundred seventy consecutive adolescents 12 to 19 years of age with PCOS, 15 of whom were small for gestational age (SGA), and 75 healthy female aged-matched adolescents as controls.
  
  
  METHODS
  Physical evaluations, fasting blood samples for measuring endocrine and metabolic parameters, and an oral glucose tolerance test.
  
  
  METHODS
  Physical, endocrine, and metabolic features.
  
  
  RESULTS
  The birth weights of adolescents with PCOS as well as those with hyperinsulinemic or insulin resistance were similar to those of the control group. The PCOS SGA adolescents had basal insulin (15.93 ± 7.16 μU/mL vs. 10.97 ± 5.79 μU/mL) and homeostasis model assessment of insulin resistance values (3.2 ± 1.54 vs. 2.19 ± 1.28) that were statistically significantly higher than in the control group. The mean levels of total testosterone in the SGA adolescents with PCOS were above the upper limit of the normal range (0.80 ng/mL).
  
  
  CONCLUSIONS
  Low birth weight may influence the appearance of hyperandrogenism and insulin resistance in a portion of adolescents with PCOS, but only 9% of the adolescents with PCOS in this study were SGA. In the majority of adolescents with PCOS, hyperinsulinemia and hyperandrogenism are related to factors other than birth weight alone.
authors: Department of Obstetrics and Gynaecology, Università degli studi Cagliari, Italy.
authors: Anna Maria
authors: AM
authors: Fulghesu
authors: Department of Obstetrics and Gynaecology, University of Pisa, Pisa, Italy.
authors: Roberta
authors: R
authors: Manca
authors: Department of Obstetrics and Gynaecology, Università degli studi Cagliari, Italy.
authors: Sara
authors: S
authors: Loi
authors: Department of Obstetrics and Gynaecology, University of Pisa, Pisa, Italy. Electronic address: ffruzzi@tin.it.
authors: Franca
authors: F
authors: Fruzzetti
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D008055:Lipids
keywords: Birth weight; PCOS; SGA