title: Cystatin C as a potential biomarker for dosing of renally excreted drugs.
abstract: The objective of the present study was to review the available pharmacokinetic evidence for the utility of cystatin C (CysC) as a marker of renal function to predict the dose of renally excreted drugs.The bibliographic search used PubMed and EMBASE databases, from its inception through to January 2014, with the following keywords 'pharmacokinetics' and 'cystatin C'.Sixteen pharmacokinetic publications were identified and seven drugs primarily excreted by the kidney were studied. Among them, only one study was performed in children, the others were performed in adults and/or elderly subjects, either healthy volunteers or patients with variable clinical conditions, such as cystic fibrosis and cancer. Most of studies (n = 13/16) demonstrated that CysC was better correlated with clearance/trough concentration of evaluated drugs compared with creatinine.Our review supports that CysC is a good marker of renal function to predict dose of renally excreted drugs. Efforts should be made to evaluate the impact of CysC in special populations in order to define its clinical value in dosing optimization.
authors: Department of Paediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.|Department of Clinical Pharmacy and Therapeutics, School of Pharmaceutical Sciences, Université Félix Houphouët-Boigny, Abidjan, Ivory Coast.
authors: Nguessan Aimé
authors: NA
authors: Brou
authors: Department of Paediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.|Clinical Investigation Center CIC1426, INSERM, Paris, France.|EA7323, Université Paris Diderot-Université Paris Descartes, Paris, France.
authors: Evelyne
authors: E
authors: Jacqz-Aigrain
authors: Department of Pharmacy, Qianfoshan Hospital Affiliated to Shandong University, Jian, China.|Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China.|Department of Paediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, APHP, Paris, France.|Clinical Investigation Center CIC1426, INSERM, Paris, France.|EA7323, Université Paris Diderot-Université Paris Descartes, Paris, France.
authors: Wei
authors: W
authors: Zhao
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D055316:Cystatin C / Q000652:urine*; D004077:Digoxin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine*; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D015415:Biomarkers; D055316:Cystatin C; D004077:Digoxin
keywords: clearance; cystatin C; dose regimen; glomerular filtration rate; pharmacokinetics; renal elimination; renal function
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