title: Clinical and pathological implications of miRNA in bladder cancer.
abstract: MicroRNAs (miRNAs) are small, noncoding RNA species with a length of 20-22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide range of biological fluids, either free or trapped in circulating microvesicles. miRNAs were proven to be involved in cell communication, both in pathological and physiological processes. Evaluation of the global expression patterns of miRNAs provides key opportunities with important practical applications, taking into account that they modulate essential biological processes such as epithelial to mesenchymal transition, which is a mechanism relevant in bladder cancer. miRNAs collected from biological specimens can furnish valuable evidence with regard to bladder cancer oncogenesis, as they also have been linked to clinical outcomes in urothelial carcinoma. Therefore, a single miRNA or a signature of multiple miRNAs may improve risk stratification of patients and may supplement the histological diagnosis of urological tumors, particularly for bladder cancer.
authors: Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Cornelia
authors: C
authors: Braicu
authors: Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Faculty of Biology and Geology, Babeş-Bolyai University, Cluj-Napoca, Romania.
authors: Roxana
authors: R
authors: Cojocneanu-Petric
authors: Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Sergiu
authors: S
authors: Chira
authors: Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Department of Medical Genetics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Anamaria
authors: A
authors: Truta
authors: Solutions of Artificial Intelligence Applications, Cluj-Napoca, Romania.
authors: Alexandru
authors: A
authors: Floares
authors: Department of Urology, The Oncology Institute "Prof Dr. Ion Chiricuta", Cluj-Napoca, Romania ; Department of Urology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Bogdan
authors: B
authors: Petrut
authors: Department of Surgery, The Oncology Institute "Prof Dr. Ion Chiricuta", Cluj-Napoca, Romania ; Department of Surgical Oncology and Gynaecological Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Patriciu
authors: P
authors: Achimas-Cadariu
authors: Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Department of Immunology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Department of Functional Genomics and Experimental Pathology, The Oncology Institute "Prof Dr. Ion Chiricuta", Cluj-Napoca, Romania ; Department of Experimental Therapeutics M.D. Anderson Cancer Center Houston, TX, USA.
authors: Ioana
authors: I
authors: Berindan-Neagoe
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D035683:MicroRNAs
keywords: bladder cancer; diagnostic; miRNA; prognostic
references: PLoS One. 2010;5(9). pii: e13067. doi: 10.1371/journal.pone.0013067
references: 20927335
references: Curr Med Chem. 2012;19(22):3653-63
references: 22680923
references: Cancer Res. 2009 Nov 1;69(21):8472-81
references: 19843843
references: Mol Cells. 2013 Jul;36(1):62-8
references: 23820886
references: Am J Pathol. 2012 May;180(5):1808-15
references: 22426337
references: Eur Urol. 2013 Jun;63(6):1091-100
references: 23200812
references: Br J Cancer. 2011 Jan 18;104(2):235-40
references: 21102580
references: Clin Cancer Res. 2014 Apr 1;20(7):1990-2000
references: 24516043
references: Clin Genitourin Cancer. 2012 Jun;10(2):106-13
references: 22386240
references: Cancer Sci. 2011 Mar;102(3):522-9
references: 21166959
references: Biochem Biophys Res Commun. 2013 May 24;435(1):82-7
references: 23618864
references: Urol Oncol. 2010 Nov-Dec;28(6):655-61
references: 19375957
references: J Mol Diagn. 2013 Sep;15(5):695-705
references: 23945108
references: Nat Rev Genet. 2009 Oct;10(10):704-14
references: 19763153
references: Exp Cell Res. 2012 May 1;318(8):944-54
references: 22387901
references: Genes Cancer. 2013 Jan;4(1-2):61-9
references: 23946872
references: Mol Ther. 2013 Mar;21(3):610-9
references: 23295946
references: Korean J Urol. 2013 Nov;54(11):791-6
references: 24255763
references: Urol Oncol. 2014 Jan;32(1):41.e31-40
references: 23911686
references: Br J Cancer. 2014 Jun 10;110(12):2945-54
references: 24823697
references: J Transl Med. 2013;11:276
references: 24180482
references: PLoS One. 2011;6(3):e18286
references: 21464941
references: Int J Cancer. 2011 Mar 15;128(6):1327-34
references: 20473948
references: Int J Biol Sci. 2012;8(10):1363-74
references: 23139634
references: Int J Cancer. 2010 Mar 1;126(5):1166-76
references: 19676045
references: PLoS One. 2012;7(12):e52280
references: 23284967
references: Biochem Biophys Res Commun. 2013 Nov 29;441(4):976-81
references: 24220339
references: Clin Chem. 2010 Nov;56(11):1733-41
references: 20847327
references: Neoplasia. 2008 Jan;10(1):1-7
references: 18231634
references: Diagn Pathol. 2012;7:159
references: 23173870
references: J Clin Pathol. 2012 Nov;65(11):970-5
references: 22685259
references: Virchows Arch. 2014 Feb;464(2):213-20
references: 24306957
references: BJU Int. 2013 Nov;112(7):1027-34
references: 23387295
references: PLoS One. 2014;9(2):e84311
references: 24520312
references: Front Genet. 2013 Nov 15;4:247
references: 24298280
references: PLoS One. 2012;7(10):e46743
references: 23056431
references: Nat Biotechnol. 2008 Apr;26(4):400-1
references: 18392022
references: Clin Cancer Res. 2009 Aug 15;15(16):5060-72
references: 19671845
references: Curr Opin Pharmacol. 2010 Oct;10(5):543-50
references: 20541466
references: Int J Cancer. 2013 Jun 1;132(11):2479-91
references: 23169479
references: PLoS One. 2013;8(7):e67686
references: 23844063
references: Mol Cancer. 2012;11:7
references: 22325146
references: Urol Oncol. 2013 Nov;31(8):1701-8
references: 22863868
references: Oncol Lett. 2013 Aug;6(2):617-623
references: 24137381
references: Oncol Rep. 2013 Oct;30(4):1949-56
references: 23877086