title: Hemoglobin, alkalic phosphatase, and C-reactive protein predict the outcome in patients with liposarcoma.
abstract: Data on prognostic biomarkers in soft tissue sarcomas are scarce. The aim of the study was to define prognostic markers in patients with a liposarcoma, a subtype of sarcoma derived from adipose tissue. We restrospectively reviewed 85 patients with liposarcoma treated at our department from May 1994 to October 2011. Kaplan-Meier curves, uni-, and multivariable Cox proportional hazard models and competing risk analysis were performed to evaluate the association between putative biomarkers with disease-specific and overall survival. We observed a significant association between both alkalic phosphatase (ALP; subhazard ratio [SHR] per 1 unit increase: 1.35; 95%CI 1.10-1.65; p = 0.005) and C-reactive protein (CRP; SHR per 1 mg/dl increase: 2,57; 95%CI 1.36-4,86; p = 0.004) with disease-specific survival. Hemoglobin (Hb) (HR per 1 g/dl increase: 065; 95%CI 0.48-0.87; p = 0.003) was associated with overall survival. These associations prevailed after multivariable adjustment for AJCC tumor stage. This study identifies CRP and ALP as novel independent predictors of disease-specific survival in patients with liposarcoma.
authors: Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
authors: Joannis
authors: J
authors: Panotopoulos
authors: Florian
authors: F
authors: Posch
authors: Benjamin
authors: B
authors: Alici
authors: Philipp
authors: P
authors: Funovics
authors: Christoph
authors: C
authors: Stihsen
authors: Gabriele
authors: G
authors: Amann
authors: Thomas
authors: T
authors: Brodowicz
authors: Reinhard
authors: R
authors: Windhager
authors: Cihan
authors: C
authors: Ay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D001317:Austria / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008080:Liposarcoma / Q000097:blood* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D002097:C-Reactive Protein; D000469:Alkaline Phosphatase
keywords: CRP; alkalic phospahtase; hemoglobin; liposarcoma; prognosis