title: Processing speed and working memory training in multiple sclerosis: a double-blind randomized controlled pilot study.
abstract: Between 40-65% of multiple sclerosis patients experience cognitive deficits, with processing speed and working memory most commonly affected. This pilot study investigated the effect of computerized cognitive training focused on improving processing speed and working memory. Participants were randomized into either an active or a sham training group and engaged in six weeks of training. The active training group improved on a measure of processing speed and attention following cognitive training, and data trended toward significance on measures of other domains. Results provide preliminary evidence that cognitive training with multiple sclerosis patients may produce moderate improvement in select areas of cognitive functioning.
authors: a Department of Psychiatry and Human Behavior , Alpert Medical School of Brown University, Rhode Island Hospital, Providence , RI , USA.
authors: Laura M
authors: LM
authors: Hancock
authors: Jared M
authors: JM
authors: Bruce
authors: Amanda S
authors: AS
authors: Bruce
authors: Sharon G
authors: SG
authors: Lynch
mesh_terms: D000328:Adult; D001245:Association Learning; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology / Q000534:rehabilitation*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004311:Double-Blind Method; D056344:Executive Function; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications; D009483:Neuropsychological Tests; D010865:Pilot Projects; D015203:Reproducibility of Results
keywords: Cognitive training; Computer-based training; Multiple sclerosis; Processing speed; Working memory