title: A novel microwave sensor to detect specific biomarkers in human cerebrospinal fluid and their relationship to cellular ischemia during thoracoabdominal aortic aneurysm repair.
abstract: Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R(2) = 0.991) and 4 GHz (R(2) = 0.975).
authors: Thoracic Aortic Aneurysm Service, Liverpool Heart & Chest Hospital, Thomas Drive, L14 3PE, Liverpool, Merseyside, UK.
authors: M
authors: M
authors: Fok
authors: M
authors: M
authors: Bashir
authors: H
authors: H
authors: Fraser
authors: N
authors: N
authors: Strouther
authors: A
authors: A
authors: Mason
mesh_terms: D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D015415:Biomarkers; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D004867:Equipment Design; D006801:Humans; D008872:Microwaves; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D012709:Serum Albumin / Q000032:analysis; D020760:Spinal Cord Ischemia / Q000134:cerebrospinal fluid / Q000517:prevention & control*; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin