title: Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis.
abstract: BACKGROUND
  Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD).
  
  
  OBJECTIVE
  To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass index (BMI) in Korean AD patients, and to explore whether these associations differ between adults and children.
  
  
  METHODS
  Serum 25-hydroxyvitamin D levels, serum LL-37, and clinical features were analyzed in a total of 72 Korean patients with AD (39 adults and 33 children) and 140 healthy control subjects (70 adults and 70 children).
  
  
  RESULTS
  Serum 25-hydroxyvitamin D levels were significantly reduced in children with AD (15.06±4.64 ng/ml) compared with normal children in the control group (16.25±6.60 ng/ml) (p=0.036). Significant inverse correlations were found between BMI and 25-hydroxyvitamin D level (r=-0.315, p=0.007) and between the SCORAD score and serum LL-37 level (r=-0.3, p=0.011) in the total AD patients.
  
  
  CONCLUSIONS
  The results showed that serum vitamin D levels were lower in children with AD than in healthy children; however, the same relation was not observed between adults with AD and healthy adults. Serum 25-hydroxyvitamin D concentration was not significantly correlated with AD severity or serum LL-37 levels in our study population.
authors: Department of Dermatology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
authors: Tae Young
authors: TY
authors: Han
authors: Department of Dermatology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
authors: Tae Seok
authors: TS
authors: Kong
authors: Eulji Medi-Bio Research Institute, Eulji University, Seoul, Korea. ; Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul, Korea.
authors: Min Ho
authors: MH
authors: Kim
authors: Department of Laboratory Medicine, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
authors: Jeong Don
authors: JD
authors: Chae
authors: Department of Dermatology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
authors: June Hyun Kyung
authors: JH
authors: Lee
authors: Department of Dermatology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
authors: Sook-Ja
authors: SJ
authors: Son
keywords: 25-Hydroxyvitamin D; Atopic dermatitis; LL-37; SCORAD