title: [Molecular regulations of phosphatidylserine eversion in plasma membrane].
abstract: Phosphatidylserine (PS), one important phospholipid of cell membranes, has crucial biological functions. Under special pathological circumstances such as cell apoptosis, cells cannot generate enough ATP for energy and the concentration of cytoplasmic Ca²⁺ increases, resulting in PS eversion. PS eversion has different biological functions in different cell types. In addition, the degree of eversion is closely associated with the progress of diseases. Therefore, it can be therapeutic targets of cancer and many other diseases. In this review, we summarize the fundamental biological functions of PS, molecular mechanisms of PS eversion, as well as its potential in translational medicine.
authors: 1.College of Life Science, Liaoning Normal University, Dalian 116029, China.|2.Lamprey Research Center, Liaoning Normal University, Dalian 116029, China.
authors: Dan
authors: D
authors: Bi
authors: 1.College of Life Science, Liaoning Normal University, Dalian 116029, China.|2.Lamprey Research Center, Liaoning Normal University, Dalian 116029, China.
authors: Yang
authors: Y
authors: Xu
authors: 1.College of Life Science, Liaoning Normal University, Dalian 116029, China.|2.Lamprey Research Center, Liaoning Normal University, Dalian 116029, China.
authors: Yue
authors: Y
authors: Pang
authors: 1.College of Life Science, Liaoning Normal University, Dalian 116029, China.|2.Lamprey Research Center, Liaoning Normal University, Dalian 116029, China.
authors: Qing-Wei
authors: QW
authors: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D010718:Phosphatidylserines / Q000032:analysis / Q000378:metabolism*
chemical_list: D010718:Phosphatidylserines; D002118:Calcium