title: Taxane resistance in prostate cancer mediated by AR-independent GATA2 regulation of IGF2.
abstract: GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling.
authors: Department of Medicine, University of Washington and GRECC-VAPSHCS, Seattle, WA 98104, USA.
authors: Stephen R
authors: SR
authors: Plymate
authors: Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors: Rupal S
authors: RS
authors: Bhatt
authors: Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: sbalk@bidmc.harvard.edu.
authors: Steven P
authors: SP
authors: Balk
mesh_terms: D000818:Animals; D050989:GATA2 Transcription Factor / Q000235:genetics*; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D050989:GATA2 Transcription Factor; C494711:GATA2 protein, human