title: Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes.
abstract: Spontaneous glucose uptake by brown adipose tissue (BAT) is lower in overweight or obese individuals and in diabetes. However, BAT metabolism has not been previously investigated in patients with type 2 diabetes during controlled cold exposure. Using positron emission tomography with (11)C-acetate, (18)F-fluoro-deoxyglucose ((18)FDG), and (18)F-fluoro-thiaheptadecanoic acid ((18)FTHA), a fatty acid tracer, BAT oxidative metabolism and perfusion and glucose and nonesterified fatty acid (NEFA) turnover were determined in men with well-controlled type 2 diabetes and age-matched control subjects under experimental cold exposure designed to minimize shivering. Despite smaller volumes of (18)FDG-positive BAT and lower glucose uptake per volume of BAT compared with young healthy control subjects, cold-induced oxidative metabolism and NEFA uptake per BAT volume and an increase in total body energy expenditure did not differ in patients with type 2 diabetes or their age-matched control subjects. The reduction in (18)FDG-positive BAT volume and BAT glucose clearance were associated with a reduction in BAT radiodensity and perfusion. (18)FDG-positive BAT volume and the cold-induced increase in BAT radiodensity were associated with an increase in systemic NEFA turnover. These results show that cold-induced NEFA uptake and oxidative metabolism are not defective in type 2 diabetes despite reduced glucose uptake per BAT volume and BAT "whitening."
authors: Department of Medicine, Centre de Recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Quebec, Canada.
authors: Denis P
authors: DP
authors: Blondin
authors: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.
authors: Sébastien M
authors: SM
authors: Labbé
authors: Department of Medicine, Centre de Recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Quebec, Canada.
authors: Christophe
authors: C
authors: Noll
authors: Department of Medicine, Centre de Recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Quebec, Canada.
authors: Margaret
authors: M
authors: Kunach
authors: Department of Medicine, Centre de Recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Quebec, Canada Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Serge
authors: S
authors: Phoenix
authors: Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Brigitte
authors: B
authors: Guérin
authors: Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors: Éric E
authors: ÉE
authors: Turcotte
authors: Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
authors: François
authors: F
authors: Haman
authors: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.
authors: Denis
authors: D
authors: Richard
authors: Department of Medicine, Centre de Recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Quebec, Canada denis.richard@criucpq.ulaval.ca.
authors: André C
authors: AC
authors: Carpentier
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000328:Adult; D003080:Cold Temperature; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
chemical_list: D005230:Fatty Acids, Nonesterified; D019788:Fluorodeoxyglucose F18; D005947:Glucose