title: Alkyloxy carbonyl modified hexapeptides as a high affinity compounds for Wnt5A protein in the treatment of psoriasis.
abstract: Psoriasis is one of the most prevalent chronic inflammatory diseases of the skin. The Wnt pathways have been documented to play essential role in stem cell self-renewal and keratinocyte differentiation in the skin. Antagonizing the Wnt5a protein would emerge as a novel therapeutics in psoriasis treatment. In this view, we have developed and characterized series of compounds by attaching varied tertiary alkyloxy carbonyl groups at the N-terminal end of the hexapeptide (Met-Asp-Gly-Cys-Glu-Leu) bestowed to inhibit Wnt/Ca2+ signaling in psoriasis. Hexapeptide compound with 1,1-diphenylethoxy carbonyl group attached to N-terminal end of hexapeptide demonstrated highest binding affinity amongst all the evaluated compounds. The compound identified in the study can be subjected further for in vitro and in vivo studies for ADMET properties.
authors: School of Biochemistry, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore (M.P.) - 452 017, India.
authors: Ankit
authors: A
authors: Kelotra
authors: School of Biochemistry, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore (M.P.) - 452 017, India.
authors: Sadashiv M
authors: SM
authors: Gokhale
authors: M.B Khalsa College, Near Gangwal Bus Stand, Indore (M.P.)-452011, India.
authors: Seema
authors: S
authors: Kelotra
authors: In silico Research Laboratory, Eminent Biosciences, Indore - 452 010, India.
authors: Vaidehi
authors: V
authors: Mukadam
authors: In silico Research Laboratory, Eminent Biosciences, Indore - 452 010, India.
authors: Komal
authors: K
authors: Nagwanshi
authors: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad - 500 016, India.
authors: Srinivas
authors: S
authors: Bandaru
authors: In silico Research Laboratory, Eminent Biosciences, Indore - 452 010, India.
authors: Anuraj
authors: A
authors: Nayarisseri
authors: Index medical College, Indore (M.P)-452010, India.
authors: Anil
authors: A
authors: Bidwai
keywords: Alkyloxy carbonyl modified hexapeptides; Molecular docking; Protein Modeling; Psoriasis; Wnt5A