title: Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation.
abstract: OBJECTIVE
  To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma.
  
  
  METHODS
  A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells.
  
  
  RESULTS
  The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migration of TE-1 cells were decreased by the overexpression of CBP.
  
  
  CONCLUSIONS
  This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Dong
authors: D
authors: Zhou
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Peng
authors: P
authors: Dong
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Yu-Min
authors: YM
authors: Li
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Fa-Cai
authors: FC
authors: Guo
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: An-Ping
authors: AP
authors: Zhang
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Run-Ze
authors: RZ
authors: Song
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Ya-Min
authors: YM
authors: Zhang
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Zhi-Yong
authors: ZY
authors: Li
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Dong
authors: D
authors: Yuan
authors: Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors: Chuan
authors: C
authors: Yang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000201:enzymology* / Q000235:genetics / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004789:Enzyme Activation; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection; D015854:Up-Regulation; D019061:src-Family Kinases / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008565:Membrane Proteins; C498710:PAG1 protein, human; D019061:src-Family Kinases
keywords: Cell growth; Csk-binding protein; Esophageal carcinoma; Invasion; Migration