title: Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence.
abstract: A synthesis of the complete tetracyclic framework of the structurally unique Lycopodium alkaloid lycopladine H has been accomplished using a strategy involving a double alkene hydroformylation/intramolecular reductive amination to form the azocane and spiro-piperidine moieties of the natural product.
authors: Department of Chemistry, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors: Pradeep S
authors: PS
authors: Chauhan
authors: Joshua R
authors: JR
authors: Sacher
authors: Steven M
authors: SM
authors: Weinreb
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D053961:Azabicyclo Compounds / Q000138:chemical synthesis*; D032502:Lycopodium / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000475:Alkenes; D053961:Azabicyclo Compounds; D011083:Polycyclic Compounds; C572830:lycopladine H