title: [Application of 18F-FDG PET/CT images in the newly diagnosed extranodal NK/T cell lymphoma].
abstract: OBJECTIVE
  This study was to explore the use value of (18)F-FDG PET/CT in patients with extranodal NK/T cell lymphoma (ENKTL).
  
  
  METHODS
  Both PET/CT and CT images were retrospectively analyzed in 43 newly diagnosed patients with ENKTL, and the anatomical position, extent of foci, subtypes, staging and therapeutic regimen determined by both these 2 imaging methods were compared, and relationship between the maximum standard uptake value (SUV(max)) and subtypes, different staging and constitutional symptoms were evaluated.
  
  
  RESULTS
  The top four anatomical positions involved were nose (76.74%), pharynx nasalis (41.86%), Waldeyer's ring (30.23%) and paranasal sinus (27.91%), respectively according to the results of the PET/CT examination, and (18)F-FDG uptake was not found in four patients in the region of upper aerodigestive tract. The PET/CT staging was significantly correlated with constitutional symptoms (P < 0.01). The mean SUV(max) of 43 patients was 13.65 ± 6.35, and the SUV(max) of advanced stages (III/IV) was higher than that of early stage (I/II). Different staging results were found in 21 patients between PET/CT and CT images, 14 patients out of them had direct influence on the treatment plan. Staging of 8 cases was changed from early stage judged by CT image into advaneed stage judged by PET/CT, and radiotherapy regimen of 6 cases at early stage were altered because of the application of PET/CT.
  
  
  CONCLUSIONS
  The location and scope of foci in ENKTL patients can be displayed more accurately by PET/CT, the PET/CT is more accurate and reliable than traditional CT image, and has considerable value in determining the treatment plan, and it should be applied in clinical practice widely.
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China; Department of Hematology, Huaian Cancer Hospital, Huaian 223200, Jiangsu Province, China.
authors: Yong-Jun
authors: YJ
authors: Hu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Jin-Hua
authors: JH
authors: Liang
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Lei
authors: L
authors: Fan
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Li
authors: L
authors: Wang
authors: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Chong-Yang
authors: CY
authors: Ding
authors: Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Tian-Nyu
authors: TN
authors: Li
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China.
authors: Wei
authors: W
authors: Xu
authors: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China. E-mail: lijianyonglm@medmail.com.cn.
authors: Jian-Yong
authors: JY
authors: Li
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18