title: Hippo signalling directs intestinal fate.
abstract: Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.
authors: Marie
authors: M
authors: Le Bouteiller
authors: Kim B
authors: KB
authors: Jensen
mesh_terms: D000217:Acyltransferases; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000818:Animals; D018797:Cell Cycle Proteins; D020397:Goblet Cells / Q000166:cytology*; D007413:Intestinal Mucosa / Q000254:growth & development*; D008297:Male; D010750:Phosphoproteins / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000235:genetics*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse; D000217:Acyltransferases; C486363:tafazzin protein, mouse