title: Economic burden of functional and organic mitral valve regurgitation.
abstract: BACKGROUND
  Very little is known about the costs of mitral regurgitation (MR) in Europe.
  
  
  OBJECTIVE
  To evaluate the cost of MR from a French National Payer perspective, based on annual costs of surgical and non-surgical patients.
  
  
  METHODS
  A 12-month retrospective population-based analysis of patient demographics, outcomes and acute hospital and post-discharge resource utilizations, extracted from the 2009 French Medical Information System.
  
  
  RESULTS
  A total of 19,868 patients with MR were identified. Surgical group (n=4099): index hospitalization length of stay (LOS), 17±14.7 days; patients discharged to rehabilitation, 72% (LOS 23±16 days); 12-month rehospitalization rate, 25%; total cost per surgical patient, €24,871±13,940 (ranging from €21,970±11,787 for mitral valve repair [n=2567, 62.6%] to €29,732±15,796 for mitral valve replacement). Non-surgical group (n=15,769): number of hospitalizations over 12 months, 3.1±1.5 (LOS 23.5±20.4 days); admitted to rehabilitation, 24% (LOS 38.8±37.6 days); total cost per patient, €12,177±10,913 (varying between €9957±9080 and €13,538±11,692 for those without and with heart failure [HF], respectively). The total observed cost for 19,868 MR patients over 12 months was €292.8 million: surgical group, €100.8 million; medical group €192.0 million. Patients with MR and HF who were managed medically consumed 45% (€132.3 million) of the overall annual cost of MR.
  
  
  CONCLUSIONS
  The costs of care associated with MR are highly heterogeneous. There are significant differences in costs and resources used between the surgical and medical MR subgroups, with further differences depending on type of surgery and presence of HF.
authors: Inserm, UMR 1087, institut du thorax, CHU de Nantes, Nantes, France. Electronic address: jeannoel.trochu@chu-nantes.fr.
authors: Jean-Noël
authors: JN
authors: Trochu
authors: Inserm, UMR 1087, institut du thorax, CHU de Nantes, Nantes, France.
authors: Thierry
authors: T
authors: Le Tourneau
authors: Cardiothoracic Surgery Department, Louis Pradel Hospital, HCL, Lyon-Bron, France.
authors: Jean-François
authors: JF
authors: Obadia
authors: Hox-Com analytiques, Vincennes, France.
authors: Gilbert
authors: G
authors: Caranhac
authors: Data Mining International, Geneva, Switzerland; LIRAES, Paris-Descartes University, Paris, France.
authors: Ariel
authors: A
authors: Beresniak
mesh_terms: D000368:Aged; D015897:Comorbidity; D017281:Cost of Illness; D005260:Female; D005602:France; D006333:Heart Failure / Q000453:epidemiology; D017721:Hospital Costs; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000191:economics* / Q000453:epidemiology; D012189:Retrospective Studies
keywords: Coût médico-économique; Health economic costs; Heart failure; Insuffisance cardiaque; Insuffisance mitrale; Mitral regurgitation; Mitral valve; Pharmacology; Valve mitrale