title: Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels.
abstract: The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.
authors: Research Center for Children's Health, 119991 Moscow, Russia; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
authors: Dimitry A
authors: DA
authors: Chistiakov
authors: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, Sydney, NSW 2052, Australia; School of Medicine, University of Western Sydney, Campbelltown, NSW 2560, Australia. Electronic address: y.bobryshev@unsw.edu.au.
authors: Yuri V
authors: YV
authors: Bobryshev
authors: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia; Institute for Atherosclerosis, Skolkovo Innovative Center, Moscow 143025, Russia.
authors: Alexander N
authors: AN
authors: Orekhov
mesh_terms: D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology*; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D018664:Interleukin-12
keywords: Arteries; Atherosclerosis; Immune reactions; Inflammation; Interleukin 12