title: A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography.
abstract: OBJECTIVE
  Myocardial perfusion imaging (MPI) systems using a multifocal collimator can reduce scan time substantially compared with conventional MPI systems. In this study, we evaluated the diagnostic accuracy of multifocal collimator SPECT/CT in coronary artery disease (CAD) detection by comparing it with coronary artery angiography (CAG).
  
  
  METHODS
  We retrospectively analyzed 50 consecutive patients who had undergone CAG and stress (201)Tl MPI multifocal collimator SPECT/CT within a 3-month period. A summed difference score (SDS) was calculated for each vascular territory from the MPI images. On CAG, a stenotic coronary artery was defined as one with luminal narrowing of ≥75 % with quantitative coronary angiography software.
  
  
  RESULTS
  We analyzed the diagnostic accuracy of coronary artery stenosis detection using the definition that a coronary artery territory was ischemic when the SDS per vessel was ≥2. We generated receiver operating characteristic (ROC) curves to evaluate the usefulness of SDS per vascular territory to find coronary artery stenoses. The area under the ROC curve was 0.86 and cut-off value was 2. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy to detect stenoses were 85, 83, 66, 94 and 84 %, respectively.
  
  
  CONCLUSIONS
  We confirmed the high accuracy of imaging with multifocal collimator SPECT/CT for detection of angiographically significant CAD.
authors: Department of Cardiology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa, 252-0392, Japan, ogino@yokohama-cu.ac.jp.
authors: Yutaka
authors: Y
authors: Ogino
authors: Yoriko
authors: Y
authors: Horiguchi
authors: Tomohiro
authors: T
authors: Ueda
authors: Tomofumi
authors: T
authors: Shiomori
authors: Masahiko
authors: M
authors: Kanna
authors: Tomoko
authors: T
authors: Kawaminami
authors: Naoki
authors: N
authors: Iinuma
authors: Yuta
authors: Y
authors: Sudo
authors: Yukiko
authors: Y
authors: Morita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000295:instrumentation / Q000379:methods*; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation / Q000379:methods*; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*