title: Calbindin D28k and S100B have a similar interaction site with the lithium-inhibitable enzyme inositol monophosphatase-1: a new drug target site.
abstract: Lithium salts (Li) are used to treat bipolar disorder patients. Li inhibits inositol-monophosphatase (IMPase)-1. Calbindin D28k (calbindin) and S100B enhance IMPase-1 activity. We compared our in silico model of the IMPase-1/calbindin complex with the crystal structure of S100B. Although calbindin and S100B have a low sequence homology, they seem to activate IMPase-1 in a similar mode. It is reasonable that molecules interfering with the interaction of IMPase-1 with either of its activators will have Li-like effects.
authors: Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, and ‡Mental Health Center, Ben-Gurion University of the Negev , Beer-Sheva 84105, Israel.
authors: Galila
authors: G
authors: Agam
authors: Orna
authors: O
authors: Almog
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D064092:Calbindin 1 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008094:Lithium / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D058990:Molecular Targeted Therapy; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D064568:S100 Calcium Binding Protein beta Subunit / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D064092:Calbindin 1; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D008094:Lithium; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase