title: Analysis of lipid-lowering therapy and factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry.
abstract: OBJECTIVE
  The aim of this study was to analyze the quality of lipid-lowering therapy in a cohort of patients with cardiovascular disease enrolled in a Moscow-based registry, and to analyze the factors affecting the regularity of statin administration in this patient category.
  
  
  METHODS
  The present study included all patients who successively sought medical advice in the Preventive Pharmacotherapy Department of the Ministry of Healthcare of the Russian Federation between May 1 and December 31, 2011 (n=274). Each patient was given a specially designed questionnaire in order to assess compliance with the prescribed treatment that included the following questions: (1) if they knew, according to the results of previous exams, that they had elevated cholesterol levels (yes, no, don't know); (2) what method of hypercholesterolemia correction they used (diet, medication, physical exercise, or other); (3) if they were taking any statins (regularly, no, irregularly); and (4) if yes, what statin preparation and what dose they were taking. Patients' compliance with statin therapy was assessed on the basis of the responses received and the regularity of statin intake.
  
  
  RESULTS
  The influence of various factors on regularity of statin intake in patients with cardiovascular disease was assessed by calculating odds ratios (OR) and 95% confidence intervals (CI) for advanced age (>70 years) (OR 0.49); higher statin dose than standard (OR 0.49); hypertension (OR 1.659); history of acute cerebrovascular event (OR 2.019); diabetes (OR 1.023); coronary heart disease (CHD) (OR 4.357); history of myocardial infarction (MI) (OR 4.838); history of coronary angiography/percutaneous coronary intervention (PCI) (OR 5.167).
  
  
  CONCLUSIONS
  Analysis of factors with impact on regular compliance with statin therapy showed that the following were most significant: CHD, history of MI, and history of PCI. Previous cerebrovascular events and presence of diabetes did not motivate these patients to take statins on a regular basis.
authors: FGBI "National Research Centre of Preventive Medicine" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia; FGBI "Joint Hospital and Polyclinic" Department of Presidential Affairs of the Russian Federation, Moscow, Russia. Electronic address: ogaisenok@gnicpm.ru.
authors: Oleg
authors: O
authors: Gaisenok
authors: FGBI "National Research Centre of Preventive Medicine" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia; IM. Sechenov First Moscow State Medical University, Moscow, Russia.
authors: Sergey
authors: S
authors: Martsevich
authors: FGBI "National Research Centre of Preventive Medicine" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
authors: Svetlana
authors: S
authors: Tripkosh
authors: FGBI "National Research Centre of Preventive Medicine" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia; IM. Sechenov First Moscow State Medical University, Moscow, Russia.
authors: Yulia
authors: Y
authors: Lukina
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009031:Moscow; D012042:Registries; D057566:Self Report; D016903:Drug Monitoring
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents
keywords: Adesão terapêutica; Compliance; Estatinas; Lipid-lowering therapy; Registo; Registry; Statins; Terapêutica de redução de lípidos