title: [Experimental study of dicholine succinate pharmacokinetics].
abstract: We have conducted for the first time an experimental study of pharmacokinetics of dicholine succinate (DCS) for different ways of its administration in rats The quantitative evaluation of DCS and its metabolites was performed by the radioactive isotope technique. Various parameters of DCS pharmacokinetics were estimated, including the dose dependence of drug content in the blood plasma, total bioavailability, distribution kinetics, and the main ways of DCS excretion.
authors: G I
authors: GI
authors: Kovalev
authors: V M
authors: VM
authors: Rychikhin
authors: V C
authors: VC
authors: Kudrin
authors: E V
authors: EV
authors: Vasil'eva
authors: E A
authors: EA
authors: Kondrakhin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002794:Choline / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D005243:Feces / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D018697:Nootropic Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D010875:Pipecolic Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D013386:Succinates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D007004:Hypoglycemic Agents; D018697:Nootropic Agents; D010875:Pipecolic Acids; D013386:Succinates; D014316:Tritium; C016374:dicolin; D002794:Choline