title: The potential of heliox as a therapy for acute respiratory distress syndrome in adults and children: a descriptive review.
abstract: BACKGROUND
  In neonatal respiratory distress syndrome (RDS) and acute RDS (ARDS) mechanical ventilation is often necessary to manage hypoxia, whilst protecting the lungs through lower volume ventilation and permissive hypercapnia. Mechanical ventilation can, however, induce or aggravate the lung injury caused by the respiratory distress. Helium, in a gas mixture with oxygen (heliox), has a low density and can reduce the flow in narrow airways and allow for lower driving pressures.
  
  
  OBJECTIVE
  The aim of this study was to review preclinical and clinical studies of the use of heliox ventilation in acute lung injury associated with respiratory failure.
  
  
  METHODS
  A systematic search was executed in the PubMed and EMBASE databases, with search terms referring to ARDS or an acute lung injury condition associated with respiratory failure and the corresponding intervention.
  
  
  RESULTS
  A total of 576 papers were retrieved. After the majority had been excluded 20 papers remained, of which 6 articles described animal models (3 paediatric; 3 adult animal models) and 14 were clinical studies, of which 12 described paediatric patient populations and 2 adult patient populations. In both paediatric and adult animal models, heliox improved gas exchange while allowing for less invasive ventilation in a wide variety of models using different ventilation modes. Clinical studies show a reduction in the work of breathing during heliox ventilation, with a concomitant increase in pH and decrease in PaCO2 levels compared to oxygen ventilation.
  
  
  CONCLUSIONS
  Although evidence so far is limited, there may be a rationale for heliox ventilation in ARDS as an intervention to improve ventilation and reduce the work of breathing.
authors: Laboratory of Experimental Intensive Care and Anaesthesiology, University of Amsterdam, Amsterdam, The Netherlands.
authors: Charlotte J P
authors: CJ
authors: Beurskens
authors: Roelie M
authors: RM
authors: Wösten-van Asperen
authors: Benedikt
authors: B
authors: Preckel
authors: Nicole P
authors: NP
authors: Juffermans
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006371:Helium; D006801:Humans; D010100:Oxygen; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D015656:Respiratory Mechanics
chemical_list: D006371:Helium; C038949:heliox; D010100:Oxygen