title: Diabetes in pregnancy outcomes: a systematic review and proposed codification of definitions.
abstract: Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which could then be used universally. A systematic review of the literature was performed on published and ongoing randomized controlled trials in the area of diabetes in pregnancy between 01 Jan 2000 and 01 Jun 2012. Other sources included the World Health Organization and Academic Society Statements. The advice of experts was sought when appropriate definitions were lacking. Among the published randomized controlled trials on diabetes and pregnancy, 171 abstracts were retrieved, 64 full texts were reviewed and 53 were included. Among the ongoing randomized controlled trials published in ClinicalTrials.gov, 90 protocols were retrieved and 25 were finally included. The definitions from these were assembled and the final maternal definitions and foetal definitions were agreed upon by consensus. It is our hope that the definitions we have provided (i) will be widely used in the reporting of future studies in the area of diabetes in pregnancy, that they will (ii) facilitate future systematic reviews and formal meta analyses and (iii) ultimately improve outcomes for mothers and babies.
authors: Department of Medicine, University of Toronto, Toronto, Canada.|Division of Endocrinology and Metabolism, Mount Sinai Hospital, Toronto, Canada.
authors: Denice S
authors: DS
authors: Feig
authors: Servei d'Endocrinologia i Nutrició, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.|Departament de Medicina, Universitat Autònoma de Barcelona, Spain; CIBER-BBN, Madrid, Spain.
authors: Rosa
authors: R
authors: Corcoy
authors: Department of Endocrinology, Odense University Hospital, Odense, Denmark.
authors: Dorte Moller
authors: DM
authors: Jensen
authors: Internal Medicine III, Endocrinology & Metabolism, Gender Medicine Unit, Medical University of Vienna, Vienna, Austria.
authors: Alexandra
authors: A
authors: Kautzky-Willer
authors: Department of Diabetes and Endocrinology, The Canberra Hospital and the Australian National University Medical School, Canberra, ACT, Australia.
authors: Christopher J
authors: CJ
authors: Nolan
authors: Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.
authors: Jeremy J N
authors: JJ
authors: Oats
authors: Department of Research and Evaluation, Kaiser Permanente Southern California, CA, USA.
authors: David A
authors: DA
authors: Sacks
authors: Servei d'Endocrinologia i Nutrició, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors: Francisca
authors: F
authors: Caimari
authors: Mater Research Institute and School of Medicine, The University of Queensland, (HDM), Brisbane, Australia.
authors: H David
authors: HD
authors: McIntyre
mesh_terms: D048909:Diabetes Complications; D016640:Diabetes, Gestational; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics; D009626:Terminology as Topic
keywords: diabetes mellitus; gestational diabetes; pregnancy; pregnancy in diabetic patients; pregnancy outcome