title: Chitosan conjugation: a facile approach to enhance the cell viability of LaF₃:Yb,Er upconverting nanotransducers in human breast cancer cells.
abstract: In this study, chitosan functionalized LaF3:Yb,Er upconverting nanotransducers (UCNTs) with controlled size and shape have been successfully synthesized by a facile one pot precipitation method. The chitosan encapsulated UCNTs show bright upconversion fluorescence upon excitation with 974 nm NIR region. The average crystallite size of UCNTs about 7.6 nm was achieved using chitosan mediated synthesis. The FTIR result confirms the chitosan coating over the LaF3:Yb,Er nanoparticles. Due to the surface modification using natural biopolymer chitosan, the as-prepared nanocrystals show excellent biocompatibility even at high dose at 200 μg/ml. To the best of our knowledge the presented work is the first report on in vitro analysis of chitosan conjugated LaF3:Yb,Er upconverting nanocrystals in human breast (MCF-7) cancer cells. These nanotransducers can be used as luminescent probes for bioimaging and deep tissue cancer therapeutic applications.
authors: Nanophotonics and Nanoelectronics Research Laboratory, Centre for Nanoscience and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, Puducherry 605014, India.
authors: Sethuraman
authors: S
authors: Gayathri
authors: Nanophotonics and Nanoelectronics Research Laboratory, Centre for Nanoscience and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, Puducherry 605014, India.
authors: Oriparambil Sivaraman Nirmal
authors: OS
authors: Ghosh
authors: CSIR-Central Leather Research Institute, Regional Centre for Extension and Development, Leather Complex, Jalandhar 144021, Punjab, India.
authors: P
authors: P
authors: Sudhakara
authors: Nanophotonics and Nanoelectronics Research Laboratory, Centre for Nanoscience and Technology, Madanjeet School of Green Energy Technologies, Pondicherry University, Kalapet, Puducherry 605014, India. Electronic address: v_kasi@hotmail.com.
authors: Annamraju Kasi
authors: AK
authors: Viswanath
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D004871:Erbium / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D006801:Humans; D007811:Lanthanum / Q000737:chemistry*; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; C083668:lanthanum trifluoride; D007811:Lanthanum; D004871:Erbium; D048271:Chitosan; D015018:Ytterbium; D005459:Fluorides
keywords: Cancer therapy; Chitosan; Enhanced cell viability; Natural biopolymer; Surface functionalization; Upconverting nanotransducers