title: No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.
abstract: The four single nucleotide polymorphisms (SNPs) rs34517613, rs3849943, rs8141797 and rs6703183, each located in a different gene, have recently been associated with risk of developing sporadic amyotrophic lateral sclerosis (SALS) in European and northern Chinese populations, but no data are yet available for other ethnic groups. Here we explored the possible association between these four SNPs and SALS in Han Chinese primarily from southern and south-western China. A total of 298 individuals with SALS from three centres in mainland China and 486 unrelated healthy controls were recruited. All subjects were successfully genotyped using the ligase detection reaction (LDR). We found no evidence that any of these SNPs are associated with risk of disease in either heterozygous or homozygous individuals (p > 0.05). Subgroup analysis based on gender showed a similar lack of association. However, subgroup analysis based on spinal- or bulbar-onset SALS revealed significant differences in the genotype distributions (p = 0.009) and minor allele frequencies of rs6703183 (p = 0.004). In conclusion, it may be premature to conclude associations between these four SNPs and SALS, which should be examined in additional ethnic groups.
authors: Department of Neurology, West China Hospital, Sichuan University , Chengdu, Sichuan Province.
authors: Ran
authors: R
authors: An
authors: Jing
authors: J
authors: Xi
authors: Xinglong
authors: X
authors: Yang
authors: Xiaoli
authors: X
authors: Yao
authors: Yanming
authors: Y
authors: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D000073885:C9orf72 Protein; D054729:Calcium-Calmodulin-Dependent Protein Kinase Type 1 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053538:Keratin-18 / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; C488421:KRT18 protein, human; D053538:Keratin-18; D008562:Membrane Glycoproteins; D011506:Proteins; C582626:SUSD2 protein, human; C517603:CAMK1G protein, human; D054729:Calcium-Calmodulin-Dependent Protein Kinase Type 1
keywords: Amyotrophic lateral sclerosis; rs34517613; rs3849943; rs6703183; rs8141797