title: Oxidative balance score as predictor of all-cause, cancer, and noncancer mortality in a biracial US cohort.
abstract: OBJECTIVE
  We previously proposed an oxidative balance score (OBS) that combines pro- and anti-oxidant exposures to represent the overall oxidative balance status of an individual. In this study, we investigated associations of the OBS with all-cause and cause-specific mortality, and explored alternative OBS weighting methods in the Reasons for Geographic and Racial Differences in Stroke Study cohort.
  
  
  METHODS
  The OBS was calculated by combining information from 14 a priori selected pro- and anti-oxidant factors and then divided into quartiles with the lowest quartile (predominance of pro-oxidants) as reference. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals for each OBS category compared with the reference.
  
  
  RESULTS
  Over a median 5.8 years of follow-up, 2079 of the 21,031 participants died. The multivariable-adjusted hazard ratios (95% confidence interval) for all-cause, cancer, and noncancer mortality for those in the highest versus the lowest equal-weighting OBS quartile were 0.70 (0.61-0.81), 0.50 (0.37-0.67), and 0.77 (0.66-0.89), respectively (P trend < .01 for all). Similar results were observed with all weighting methods.
  
  
  CONCLUSIONS
  These results suggest that individuals with a greater balance of antioxidant to pro-oxidant lifestyle exposures may have lower mortality.
authors: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA. Electronic address: soyeon.kong@gmail.com.
authors: So Yeon
authors: SY
authors: Kong
authors: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA.
authors: Michael
authors: M
authors: Goodman
authors: Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.
authors: Suzanne
authors: S
authors: Judd
authors: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; Winship Cancer Institute, Emory University, Atlanta, GA.
authors: Roberd M
authors: RM
authors: Bostick
authors: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
authors: W Dana
authors: WD
authors: Flanders
authors: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
authors: William
authors: W
authors: McClellan
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000401:mortality*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D016016:Proportional Hazards Models; D044469:Racial Groups / Q000706:statistics & numerical data; D012737:Sex Factors; D014481:United States / Q000453:epidemiology
keywords: Mortality; Oxidative balance score; Oxidative stress