title: Strategies to improve the outcome in locally advanced pancreatic cancer.
abstract: Pancreatic cancer is associated with the worst prognosis of all gastrointestinal malignancies. The major reasons for the dismal outcome are late diagnosis due to unspecific symptoms and aggressive tumor biology. Although highly effective chemotherapeutic options have emerged within the last decade, radical resection offers the only chance of cure. Only 10-20% of patients are resectable at presentation, and 30-40% present with borderline resectable or locally advanced/unresectable tumors. Even if resectable, the 5-year-survival rate after complete resections remains unsatisfactory, with less than 25%. This article gives an overview on current therapy standards as well as on new approaches especially for locally advanced tumors and outlines the importance of ongoing research to improve prognosis.
authors: Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany - christoph.spaeth@tum.de.
authors: C
authors: C
authors: Späth
authors: U
authors: U
authors: Nitsche
authors: T
authors: T
authors: Müller
authors: C
authors: C
authors: Michalski
authors: M
authors: M
authors: Erkan
authors: B
authors: B
authors: Kong
authors: J
authors: J
authors: Kleeff
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D017115:Catheter Ablation / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D019317:Evidence-Based Medicine; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008197:Lymph Node Excision; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010180:Pancreatectomy / Q000379:methods / Q000401:mortality; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology