title: Using event-related potential P300 as an electrophysiological marker for differential diagnosis and to predict the progression of mild cognitive impairment: a meta-analysis.
abstract: P300 event-related potential component may sensitively predict mild cognitive impairment (MCI) progression. Here, pooled effect size estimates of P300 amplitude and latency were computed at midline electrodes among controls, MCI patients, and Alzheimer's disease (AD) patients. Baseline data were compared to one-year follow-up data. MCI patients showed decreased P300 amplitude and prolonged latency compared to controls. Pooled standardized mean differences (SMDs) were -0.67 (95 % CI -1.12 to -0.23, P = 0.003) and 0.90 (95 % CI 0.66-1.14, P < 0.00001), respectively. P300 latency decreased in MCI compared to AD patients where the pooled SMD was -0.52 (95 % CI -0.85 to -0.18, P = 0.003). Amplitude and latency differed between MCI baseline and follow-up. Pooled SMDs were 0.47 (95 % CI 0.29 to -0.65, P < 0.00001) and -0.52 (95 % CI -0.71 to -0.34, P < 0.00001), respectively. Group differences in MCI P300 latency existed compared to control and AD patients. P300 latency may therefore be a sensitive indicator for early cognitive decline or disease progression in MCI patients and identifying elderly patient progression to MCI and/or AD.
authors: Department of Medical Psychology, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, Heilongjiang, China.
authors: Shixiang
authors: S
authors: Jiang
authors: Changda
authors: C
authors: Qu
authors: Fengjun
authors: F
authors: Wang
authors: Yupeng
authors: Y
authors: Liu
authors: Zhengxue
authors: Z
authors: Qiao
authors: Xiaohui
authors: X
authors: Qiu
authors: Xiuxian
authors: X
authors: Yang
authors: Yanjie
authors: Y
authors: Yang
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D003937:Diagnosis, Differential; D018450:Disease Progression; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D006801:Humans; D010812:Physical Stimulation; D011930:Reaction Time / Q000502:physiology