title: Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen.
abstract: The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.
authors: Center for Biostatistics in AIDS Research, Department of Biostatistics, FXB 604B, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA, 02115, USA, alee@sdac.harvard.edu.
authors: Anthony J
authors: AJ
authors: Lee
authors: Ronald J
authors: RJ
authors: Bosch
authors: Scott R
authors: SR
authors: Evans
authors: Kunling
authors: K
authors: Wu
authors: Taylor
authors: T
authors: Harrison
authors: Philip
authors: P
authors: Grant
authors: David B
authors: DB
authors: Clifford
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents