title: Change in estrogen receptor, HER2, and Ki-67 status between primary breast cancer and ipsilateral breast cancer tumor recurrence.
abstract: BACKGROUND
  Changes in the biological marker status between primary and recurrent tumors are observed in breast cancer. However, their clinical significance is still uncertain, especially for patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery.
  
  
  METHODS
  A total of 117 patients with IBTR without distant metastases were enrolled in this study. All patients were examined for estrogen receptor (ER), HER2, and Ki-67 in both the primary tumors and paired IBTR. We evaluated the impact of changes in these biomarkers between primary tumors and IBTR on the prognosis after IBTR.
  
  
  RESULTS
  There were no associations of changes in the ER, HER2 status with distant disease-free survival (DDFS) after surgical resection of IBTR, whereas the change in the Ki-67 status between the primary tumors and IBTR was significantly correlated with DDFS (unadjusted: p = 0.0094; adjusted: p = 0.013). Patients in the "increased or remained high" Ki-67 group had a significantly shorter DDFS than those in the "decreased or remained low" Ki-67 group (5-year DDFS: 55.5 vs. 79.3%, respectively, p = 0.0084 by log-rank test).
  
  
  CONCLUSIONS
  An increased or persistently high Ki-67 status in the IBTR was significantly correlated with a poorer prognosis after IBTR.
authors: Dept. of Breast & Endocrine Surgery, Kumamoto City Hospital, Kumamoto, Japan.
authors: Y
authors: Y
authors: Okumura
authors: Dept. of Breast & Endocrine Surgery, Kumamoto City Hospital, Kumamoto, Japan.
authors: R
authors: R
authors: Nishimura
authors: Dept. of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: K
authors: K
authors: Nakatsukasa
authors: Dept. of Breast Surgery, St. Luke's International Hospital, Tokyo, Japan.
authors: A
authors: A
authors: Yoshida
authors: Dept. of Surgery, Breast Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors: N
authors: N
authors: Masuda
authors: Division of Breast Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
authors: M
authors: M
authors: Tanabe
authors: Dept. of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
authors: T
authors: T
authors: Shien
authors: Section of Breast and Endocrine Surgery, Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan.
authors: S
authors: S
authors: Tanaka
authors: Dept. of Pathology, Kumamoto City Hospital, Kumamoto, Japan.
authors: N
authors: N
authors: Arima
authors: Dept. of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors: Y
authors: Y
authors: Komoike
authors: Dept. of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: T
authors: T
authors: Taguchi
authors: Division of Breast Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
authors: T
authors: T
authors: Iwase
authors: Dept. of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
authors: H
authors: H
authors: Inaji
authors: Dept. of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. Electronic address: isitobi-ma@mc.pref.osaka.jp.
authors: M
authors: M
authors: Ishitobi
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C508053:ERBB2 protein, human
keywords: Breast cancer; Ipsilateral breast tumor recurrence; Ki-67