title: Activation-induced cytidine deaminase and active DNA demethylation.
abstract: The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome-wide active demethylation processes. Conversely, we present evidence that favors AID involvement in gene-specific demethylation events underlying cell differentiation.
authors: B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle de Melchor Fernandez Almagro 3, 28029 Madrid, Spain.
authors: Almudena R
authors: AR
authors: Ramiro
authors: Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, Oeiras, Portugal. Electronic address: vbarreto@igc.gulbenkian.pt.
authors: Vasco M
authors: VM
authors: Barreto
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003562:Cytidine / Q000235:genetics / Q000378:metabolism*; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D003562:Cytidine; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase