title: Hyperthermic intraperitoneal chemotherapy for the treatment of recurrent ovarian cancer in elderly women.
abstract: Our aim was to evaluate the morbidity and survival associated with combined cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of recurrent ovarian cancer for patients aged 70 years and older. We conducted a monocentric study in a French university hospital and collected data on 15 women aged ≥ 70 years, treated by cytoreduction and HIPEC for ovarian cancer relapse. The median overall survival was 35 months, with a median disease-free survival of 15.6 months. When a Peritoneal Cancer Index subgroup analysis was performed, a statistically significant difference in the disease-free survival could be observed for a Peritoneal Cancer Index ≤ 13 (p = 0.036). A trend towards improvement of disease-free survival was observed when the Completeness of Cytoreductive Score was equal to 0 (p = 0.0915).
authors: Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, University Hospital Center of Archet II, University of Nice-Sophia Antipolis, Nice, France.
authors: Jérôme
authors: J
authors: Delotte
authors: Tatiana
authors: T
authors: Arias
authors: Olivier
authors: O
authors: Guerin
authors: Rabia
authors: R
authors: Boulahssass
authors: Isabelle
authors: I
authors: Bereder
authors: André
authors: A
authors: Bongain
authors: Daniel
authors: D
authors: Benchimol
authors: Jean Marc
authors: JM
authors: Bereder
mesh_terms: D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin
keywords: Elderly; hyperthermic intraperitoneal chemotherapy; morbidity; oncology; ovarian cancer; survival