title: Abnormal functional connectivity of the amygdala-based network in resting-state FMRI in adolescents with generalized anxiety disorder.
abstract: BACKGROUND
  We aimed to investigate the disruptions of functional connectivity of amygdala-based networks in adolescents with untreated generalized anxiety disorder (GAD).
  
  
  METHODS
  A total of 26 adolescents with first-episode GAD and 20 normal age-matched volunteers underwent resting-state and T1 functional magnetic resonance imaging (fMRI). We analyzed the correlation of fMRI signal fluctuation between the amygdala and other brain regions. The variation of amygdala-based functional connectivity and its correlation with anxiety severity were investigated.
  
  
  RESULTS
  Decreased functional connectivity was found between the left amygdala and left dorsolateral prefrontal cortex. An increased right amygdala functional connectivity with right posterior and anterior lobes of the cerebellum, insula, superior temporal gyrus, putamen, and right amygdala were found in our study. Negative correlations between GAD scores and functional connectivity of the right amygdala with the cerebellum were also observed in the GAD adolescents.
  
  
  CONCLUSIONS
  Adolescents with GAD have abnormalities in brain regions associated with the emotional processing pathways.
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Wen-jing
authors: WJ
authors: Liu
authors: Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China (mainland).
authors: Da-zhi
authors: DZ
authors: Yin
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Wen-hong
authors: WH
authors: Cheng
authors: Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China (mainland).
authors: Ming-xia
authors: MX
authors: Fan
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Mei-na
authors: MN
authors: You
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Wei-wei
authors: WW
authors: Men
authors: Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China (mainland).
authors: Li-li
authors: LL
authors: Zang
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Dian-hong
authors: DH
authors: Shi
authors: Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).
authors: Fang
authors: F
authors: Zhang
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000502:physiology*; D001008:Anxiety Disorders / Q000473:pathology*; D002681:China; D004644:Emotions / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000002:abnormalities*; D017397:Prefrontal Cortex / Q000502:physiology*; D011795:Surveys and Questionnaires