title: miRNAs in urine: a mirror image of kidney disease?
abstract: miRNAs are short non-coding RNAs that control post-transcriptional regulation of gene expression. They are found ubiquitously in tissue and body fluids and participate in the pathogenesis of many diseases. Due to these characteristics and their stability, miRNAs could serve as biomarkers of different pathologies of the kidney. Urine is a non-invasive reservoir of molecules, especially indicative of the urinary system. In this review, we focus on urinary miRNAs and their potential to serve as biomarkers in kidney disease. Past studies show that urinary miRNAs correlate with renal dysfunctions and with processes involved in the pathophysiology. However, these studies also stress the need for future research focusing on large-scale studies to confirm the usability of urinary miRNAs as diagnostic and/or prognostic markers of different kidney diseases in clinical practice.
authors: Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, 1 avenue Jean Poulhès, B.P. 84225, 31432 Toulouse Cedex 4, France.
authors: Theofilos
authors: T
authors: Papadopoulos
authors: Julie
authors: J
authors: Belliere
authors: Jean-Loup
authors: JL
authors: Bascands
authors: Eric
authors: E
authors: Neau
authors: Julie
authors: J
authors: Klein
authors: Joost P
authors: JP
authors: Schanstra
mesh_terms: D015415:Biomarkers; D015870:Gene Expression; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000652:urine*; D035683:MicroRNAs / Q000235:genetics* / Q000652:urine*; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D012333:RNA, Messenger
keywords: biomarker; canonical pathways; computational analysis; kidney; kidney disease; miRNA; urine