title: Association between serum osteocalcin levels and non-alcoholic fatty liver disease in women.
abstract: OBJECTIVE
  Osteocalcin was found to have a significant role in insulin resistance. Insulin resistance is considered a pathophysiological mechanism of nonalcoholic fatty liver disease (NAFLD). However, the relationship between serum osteocalcin level and NAFLD is not well known.
  
  
  METHODS
  A total of 7,067 women undergoing abdominal ultrasonography, bone mineral density, and serum osteocalcin level measurement were analyzed.
  
  
  RESULTS
  Serum osteocalcin level was independently associated with menopausal status, bone mineral density, calcium, phosphate, alkaline phosphatase, fasting blood glucose, triglyceride, low-density lipoprotein cholesterol, alanine aminotransferase, γ-glutamyltransferase, and NAFLD. When women were grouped according to their menopausal status and bone mineral density, the serum osteocalcin level showed an independent inverse association with NAFLD in premenopausal women without osteopenia or osteoporosis (n = 2,941) [odd ratio (OR): 0.94, 95% confidence interval (CI): 0.91-0.96, p < 0.001] and postmenopausal women without osteopenia or osteoporosis (n = 2,155) (OR: 0.96, 95% CI: 0.95-0.98, p < 0.001), however, not in premenopausal (n = 308) or postmenopausal women (n = 1,663) with osteopenia or osteoporosis.
  
  
  CONCLUSIONS
  The serum osteocalcin level was an independent factor associated with NAFLD, especially for women with normal bone mineral density. © 2015 S. Karger AG, Basel.
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Dong Hyun
authors: DH
authors: Sinn
authors: Geum-Youn
authors: GY
authors: Gwak
authors: Sang Youl
authors: SY
authors: Rhee
authors: Juhee
authors: J
authors: Cho
authors: Hee Jung
authors: HJ
authors: Son
authors: Yong-Han
authors: YH
authors: Paik
authors: Moon Seok
authors: MS
authors: Choi
authors: Joon Hyeok
authors: JH
authors: Lee
authors: Kwang Cheol
authors: KC
authors: Koh
authors: Byung Chul
authors: BC
authors: Yoo
authors: Seung Woon
authors: SW
authors: Paik
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015519:Bone Density; D002118:Calcium / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008593:Menopause / Q000097:blood; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000000981:diagnostic imaging; D016017:Odds Ratio; D015675:Osteocalcin / Q000097:blood*; D010744:Phosphoric Monoester Hydrolases / Q000097:blood; D017697:Premenopause / Q000097:blood; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D008077:Lipoproteins, LDL; D014280:Triglycerides; D015675:Osteocalcin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010744:Phosphoric Monoester Hydrolases; D002118:Calcium