title: Pulmonary light-chain deposition disease: CT and pathology findings in nine patients.
abstract: OBJECTIVE
  To review the clinical features of nine patients with pulmonary light-chain deposition disease (LCDD) and record their high-resolution CT (HRCT) and histopathological findings.
  
  
  METHODS
  Patients with a diagnosis of LCDD on lung biopsy specimen were retrospectively identified. The HRCT characteristics of nodules, cysts, and ancillary findings; change at follow-up; and histopathological findings were documented.
  
  
  RESULTS
  Features common to all nine cases were thin-walled cysts. In seven cases, vessels traversing the cysts were identified. The majority of patients (8/9) had at least one pulmonary nodule. There was no zonal predominance of either cysts or nodules. The disease appeared stable in the majority of cases with no serial change in HRCT appearances (5/6 cases with follow-up data, mean duration 29 months).
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the largest series of pulmonary LCDD patients in the literature, and the first systematic assessment of HRCT findings. Pulmonary cysts are a unifying feature, usually with pulmonary nodules, and serial change on HRCT is unusual.
authors: Department of Radiology, St George's Hospital, Blackshaw Road, London, SW17 0QT, UK.
authors: S
authors: S
authors: Sheard
authors: Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, UK.
authors: A G
authors: AG
authors: Nicholson
authors: Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK.
authors: L
authors: L
authors: Edmunds
authors: Department of Histopathology, Royal Marsden Hospital, Fulham Road, SW3 6JJ, UK.
authors: A C
authors: AC
authors: Wotherspoon
authors: Department of Radiology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK. Electronic address: david.hansell@rbht.nhs.uk.
authors: D M
authors: DM
authors: Hansell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D007147:Immunoglobulin Light Chains