title: Protective effect of epimedium combined with oligomeric proanthocyanidins on exercise-induced renal ischemia-reperfusion injury of rats.
abstract: OBJECTIVE
  This paper studied the protective effect and mechanism of epimedium combined with oligomeric proanthocyanidins on exercise-induced renal ischemia-reperfusion injury of rats.
  
  
  METHODS
  In the experiment, the rats were given exhaustive swimming training and then their blood urea nitrogen (BUN) and other biochemical indexes were measured after they were given gastric perfusion with 6.01 g/kg doze of epimedium and 50 mg/kg doze of oligomeric proanthocyanidins for 56 days.
  
  
  RESULTS
  The result indicated that 8 weeks of over training led to ischemia-reperfusion injury of rats. Moreover, their kidney tissues were significantly changed pathologically and renal functions drastically damaged. BUN and serum creatinine increased and EOM group (P < 0.05), OPCOM group (P < 0.05) and EOPCOM group (P < 0.01) were lower than OM group. EOPCOM group was lower than OPCOM group. SOD activity decreased, EOM group (P < 0.05), OPCOM group (P < 0.05), EOPCOM group (P < 0.01) higher than OM group, and EOPCOM group (P < 0.05) higher than OPCOM group. The content of MDA increased, EOM group (P < 0.05), OPCOM group (P < 0.05), EOPCOM group (P < 0.01) lower than OM group, and EOPCOM group (P < 0.05) lower than OPCOM group.
  
  
  CONCLUSIONS
  Both epimedium and oligomeric proanthocyanidins can boost SOD activity, clean oxygen radicals, clean and alleviate peroxidation of lipids, which exert protection on exercise-induced renal ischemia-reperfusion. The two combined yield a much better result.
authors: School of Physical Education, Nanyang Normal University Nanyang 473000, Henan Province, China.
authors: Hua
authors: H
authors: Zhang
authors: School of Rehabilitation, Gannan Medical University Ganzhou 341000, Jiangxi Province, China.
authors: Xiao-Qin
authors: XQ
authors: Sun
authors: Sport Science College, Beijing Sport University Beijing 100084, Beijing City, China.
authors: Jian-Min
authors: JM
authors: Cao
authors: College of Biochemical Engineering, Beijing Union University Beijing 100023, China.
authors: Hai-Tao
authors: HT
authors: Zhou
authors: Sport Science College, Beijing Sport University Beijing 100084, Beijing City, China.
authors: Xian
authors: X
authors: Guo
authors: Sport Science College, Beijing Sport University Beijing 100084, Beijing City, China.
authors: Yi
authors: Y
authors: Wang
keywords: Epimedium; exercise-induced ischemia-reperfusion; oligomeric proanthocyanidins