title: Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis.
abstract: We describe a new technique of platelet-rich plasma (PRP) infiltration for the treatment of severe knee osteoarthritis. PRP intra-articular infiltration is a promising treatment for knee osteoarthritis, but it still has some limitations in high-degree osteoarthritis. Diagnosis of osteoarthritis is based on clinical and radiographic findings, and patients with grade III or IV knee tibiofemoral osteoarthritis based on the Ahlbäck scale are considered candidates for this technique. The technique consists of performing intraosseous infiltration of PRP into the subchondral bone, which acts on this tissue and consequently on cartilage-bone communication. Although the intraosseous injection hinders the conventional knee intra-articular infiltration, it allows an extension of the range of action of the PRP, which acts directly on the subchondral bone, which is involved in the progression of osteoarthritis. Thus this technique involves a new administration of PRP that can delay knee arthroplasty; moreover, it can be applied for not only severe osteoarthritis but also other pathologies in which the subchondral bone is critical in the etiology, such as necrosis and osteochondral lesions.
authors: Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.
authors: Mikel
authors: M
authors: Sánchez
authors: Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain ; Biotechnology Institute, Vitoria-Gasteiz, Spain.
authors: Nicolás
authors: N
authors: Fiz
authors: Arthroscopic Surgery Unit, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.
authors: Jorge
authors: J
authors: Guadilla
authors: Biotechnology Institute, Vitoria-Gasteiz, Spain ; Foundation Eduardo Anitua, Vitoria-Gasteiz, Spain.
authors: Sabino
authors: S
authors: Padilla
authors: Biotechnology Institute, Vitoria-Gasteiz, Spain ; Foundation Eduardo Anitua, Vitoria-Gasteiz, Spain.
authors: Eduardo
authors: E
authors: Anitua
authors: Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.
authors: Pello
authors: P
authors: Sánchez
authors: Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, Vitoria-Gasteiz, Spain.
authors: Diego
authors: D
authors: Delgado