title: Facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines.
abstract: Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.
authors: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Road 15, Xi'an 710032, China. xjyypharmacy@126.com.
authors: Yan-Yan
authors: YY
authors: Jia
authors: Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. lixiaoye@fmmu.edu.cn.
authors: Xiao-Ye
authors: XY
authors: Li
authors: Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. ping_an1718@outlook.com.
authors: Ping-An
authors: PA
authors: Wang
authors: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Road 15, Xi'an 710032, China. adwen@fmmu.edu.cn.
authors: Ai-Dong
authors: AD
authors: Wen
mesh_terms: D000272:Adipates / Q000737:chemistry; D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D057786:Peptidomimetics; D010627:Phenethylamines / Q000737:chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000272:Adipates; D000438:Alcohols; D004151:Dipeptides; D057786:Peptidomimetics; D010627:Phenethylamines; D011759:Pyrrolidines; C012481:phenylalaninol; D010649:Phenylalanine; C032519:pyrrolidine