title: S-ketamine influences strategic allocation of attention but not exogenous capture of attention.
abstract: We investigated whether s-ketamine differentially affects strategic allocation of attention. In Experiment 1, (1) a less visible cue was weakly masked by the onsets of competing placeholders or (2) a better visible cue was not masked because it was presented in isolation. Both types of cue appeared more often opposite of the target (75%) than at target position (25%). With this setup, we tested for strategic attention shifts to the opposite side of the cues and for exogenous attentional capture toward the cue's side in a short cue-target interval, as well as for (reverse) cueing effects in a long cue-target interval after s-ketamine and after placebo treatment in a double-blind within-participant design. We found reduced strategic attention shifts after cues presented without placeholders for the s-ketamine compared to the placebo treatment in the short interval, indicating an early effect on the strategic allocation of attention. No differences between the two treatments were found for exogenous attentional capture by less visible cues, suggesting that s-ketamine does not affect exogenous attentional capture in the presence of competing distractors. Experiment 2 confirmed that the competing onsets of the placeholders prevented the strategic cueing effect. Taken together, the results indicate that s-ketamine affects strategic attentional capture, but not exogenous attentional capture. The findings point to a more prominent role of s-ketamine during top-down controlled forms of attention that require suppression of automatic capture than during automatic capture itself.
authors: Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010 Vienna, Austria. Electronic address: isabella.fuchs@univie.ac.at.
authors: Isabella
authors: I
authors: Fuchs
authors: Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010 Vienna, Austria.
authors: Ulrich
authors: U
authors: Ansorge
authors: Faculty of Psychology, University of Vienna, Liebiggasse 5, 1010 Vienna, Austria.
authors: Christoph
authors: C
authors: Huber-Huber
authors: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Functional Neuroimaging Lab, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Anna
authors: A
authors: Höflich
authors: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Functional Neuroimaging Lab, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors: Rupert
authors: R
authors: Lanzenberger
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects*; D018592:Cross-Over Studies; D003463:Cues; D004311:Double-Blind Method; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D055815:Young Adult
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine
keywords: Attentional capture; Exogenous capture; IOR; Inhibition of return; S-ketamine; Strategic attention shifts