title: [Deceleration of cataract development in rats under the action of N-acetylcarnosine and D-pantethine mixture].
abstract: The effect of a mixture of N-acetylcarnosine and D-pantethine (1 : 1, m/m) on UV-A induced cataract in rats was studied. It is shown that instillation of a 5% mixture into the eyes or intraperitoneal injections (25 or 150 mg/kg) inhibit the formation of cataracts, starting from 82nd day of the experiment (p < 0.03), after which the protective effect of the mixture significantly increases (p = 0.0003). UV-A irradiation significantly (p < 0.01) increased the content of water-insoluble proteins in the lens. The use of the mixture of N-Acetylcarnosine and D-pantethine prevented (p < 0.001) an increase in the content of water-insoluble proteins caused by UV-A irradiation. Gel permeation chromatography data showed that, in the control group, water insoluble proteins consist of 3 fractions (40 kDa, 100 - 200 kDa, and1000 kDa). UV-A irradiation reduced the amount of protein in fraction 1 and increases the amount of protein in the fractions 2 and 3. The use of the mixture of N-acetylcarnosine and D-pantethine reduced the effects of UV-A light. The authors attribute the effect of the N-acetylcarnosine and D-pantethine mixture to their chaperone-like properties.
authors: S É
authors: SÉ
authors: Avetisov
authors: N L
authors: NL
authors: Sheremet
authors: K O
authors: KO
authors: Muranov
authors: N B
authors: NB
authors: Polianskiĭ
authors: G S
authors: GS
authors: Polunin
authors: M A
authors: MA
authors: Ostrovskiĭ
mesh_terms: D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002850:Chromatography, Gel; D004338:Drug Combinations; D005136:Eye Proteins / Q000737:chemistry; D007274:Injections, Intraperitoneal; D007908:Lens, Crystalline / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D009883:Ophthalmic Solutions; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D066329:Protein Aggregates / Q000187:drug effects* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D005136:Eye Proteins; D009883:Ophthalmic Solutions; D020011:Protective Agents; D066329:Protein Aggregates; C033681:N-acetylcarnosine; D010204:Pantetheine; C005425:pantethine; D002336:Carnosine