title: Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes.
abstract: BACKGROUND
  There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood.
  
  
  OBJECTIVE
  The objective of the present investigation was to explore the clinical and laboratory features of seven patients with AML-M2/M3.
  
  
  METHODS
  We retrospectively assessed cell morphology, cytochemistry, immunophenotype, cytogenetics, and clinical features of seven patients with this rare subtype of AML.
  
  
  RESULTS
  All seven cases had thrombocytopenia, coagulation abnormalities, >20% myeloblasts and abnormal promyelocytes. The PML/RARα fusion gene was present in six patients and two patients presented a mixed PML/RARα and AML1/ETO genotype. Five cases achieved CR and two cases did not achieve remission and one case transform into AML-M2 after CR1.
  
  
  CONCLUSIONS
  The clinical and laboratory features of seven patients with AML-M2/M3 are demonstrated in the present study, providing information on the FAB sub-classification.
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: GanLin
authors: G
authors: He
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: ChunYan
authors: C
authors: Wang
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: QingEn
authors: Q
authors: Li
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: Huo
authors: H
authors: Tan
authors: Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road, Guangzhou, China.
authors: FuXiong
authors: F
authors: Chen
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: ZhenQian
authors: Z
authors: Huang
authors: State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road, Guangzhou, China.
authors: BaoDan
authors: B
authors: Yu
authors: State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road, Guangzhou, China.
authors: LiXia
authors: L
authors: Zheng
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: RunHui
authors: R
authors: Zheng
authors: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, No. 1 Kangda Road, Haizhu District, 510000 Guangzhou, China.
authors: Dan
authors: D
authors: Liu
keywords: AML-M2/M3 subtype; Abnormal promyelocytes; Acute myeloid leukemia (AML); Mixed phenotype; Myeloblasts