title: Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.
abstract: Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics.
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Francisco
authors: F
authors: Westermeier
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Mario
authors: M
authors: Navarro-Marquez
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Camila
authors: C
authors: López-Crisosto
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Roberto
authors: R
authors: Bravo-Sagua
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Clara
authors: C
authors: Quiroga
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile.
authors: Mario
authors: M
authors: Bustamante
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
authors: Hugo E
authors: HE
authors: Verdejo
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
authors: Ricardo
authors: R
authors: Zalaquett
authors: Anesthesiology Division, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
authors: Mauricio
authors: M
authors: Ibacache
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile; Internal Medicine Division of Cardiology, Dallas, TX, USA; Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Valentina
authors: V
authors: Parra
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
authors: Pablo F
authors: PF
authors: Castro
authors: Internal Medicine Division of Cardiology, Dallas, TX, USA; Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Beverly A
authors: BA
authors: Rothermel
authors: Internal Medicine Division of Cardiology, Dallas, TX, USA; Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Joseph A
authors: JA
authors: Hill
authors: Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile; Internal Medicine Division of Cardiology, Dallas, TX, USA; Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: slavander@uchile.cl.
authors: Sergio
authors: S
authors: Lavandero
mesh_terms: D000818:Animals; D058065:Diabetic Cardiomyopathies / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D007328:Insulin
keywords: Diabetic cardiomyopathy; Insulin signaling; Mitochondrial dynamics