title: Molecular and immunological biomarkers to predict IVIg response.
abstract: Some patients with autoimmune and inflammatory diseases treated with intravenous immunoglobulin G (IVIg) as a first line therapy are refractory. Identification of predictive biomarker(s) to segregate responders and non-responders to IVIg therapy remains critical. A number of biomarkers, particularly in Kawasaki disease, have shown potential for predicting response to IVIg.
authors: Institut National de la Santé et de la Recherche Médicale, Unité 1138, Paris, F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and therapeutic immunointervention, Paris, F-75006, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France; Department of Pediatric Rheumatology, National Referral Centre of Auto-inflammatory Diseases, CHU de Bicêtre, le Kremlin Bicêtre, F-94270, France.
authors: Caroline
authors: C
authors: Galeotti
authors: Institut National de la Santé et de la Recherche Médicale, Unité 1138, Paris, F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and therapeutic immunointervention, Paris, F-75006, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France; Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, F-75006, France; International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohematology, Mumbai, 400012, India.
authors: Srini V
authors: SV
authors: Kaveri
authors: Institut National de la Santé et de la Recherche Médicale, Unité 1138, Paris, F-75006, France; Centre de Recherche des Cordeliers, Equipe - Immunopathology and therapeutic immunointervention, Paris, F-75006, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, F-75006, France; Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, F-75006, France; International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohematology, Mumbai, 400012, India. Electronic address: jagadeesh.bayry@crc.jussieu.fr.
authors: Jagadeesh
authors: J
authors: Bayry
mesh_terms: D019175:DNA Methylation; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: D016756:Immunoglobulins, Intravenous; D017452:Receptors, IgG
keywords: Fcγ receptor; Guillain-Barré syndrome; Kawasaki disease; cytokines; immune thrombocytopenia; intravenous immunoglobulin