title: Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project.
abstract: The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10(-7)) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10(-6)) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.
authors: South Texas Diabetes and Obesity Institute, Regional Academic Health Center, University of Texas at San Antonio Harlingen, TX, USA.
authors: Sandra L
authors: SL
authors: Laston
authors: Department of Nutrition, University of North Carolina at Chapel Hill Kannapolis, NC, USA ; University of North Carolina Nutrition Research Institute, University of North Carolina at Chapel Hill Kannapolis, NC, USA.
authors: V Saroja
authors: VS
authors: Voruganti
authors: Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA.
authors: Karin
authors: K
authors: Haack
authors: Department of Biochemistry, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Vallabh O
authors: VO
authors: Shah
authors: Department of Biochemistry, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Arlene
authors: A
authors: Bobelu
authors: Department of Biochemistry, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Jeanette
authors: J
authors: Bobelu
authors: Department of Biochemistry, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Donica
authors: D
authors: Ghahate
authors: Department of Biochemistry, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Antonia M
authors: AM
authors: Harford
authors: Dialysis Clinic, Inc., Albuquerque, NM USA.
authors: Susan S
authors: SS
authors: Paine
authors: Arbor Research Collaborative for Health Ann Arbor, MI, USA.
authors: Francesca
authors: F
authors: Tentori
authors: Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA.
authors: Shelley A
authors: SA
authors: Cole
authors: Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA.
authors: Jean W
authors: JW
authors: MacCluer
authors: Department of Genetics, Texas Biomedical Research Institute San Antonio, TX, USA ; Southwest National Primate Research Center San Antonio, TX, USA.
authors: Anthony G
authors: AG
authors: Comuzzie
authors: Dialysis Clinic, Inc., Albuquerque, NM USA ; Department of Medicine, Division of Nephrology, University of New Mexico School of Medicine Albuquerque, NM, USA.
authors: Philip G
authors: PG
authors: Zager
keywords: association; kidney function; serum uric acid; single nucleotide polymorphisms; triglycerides