title: Anti-inflammatory effect of water-soluble complex of 1'-acetoxychavicol acetate with highly branched β-1,3-glucan on contact dermatitis.
abstract: The anti-inflammatory effect on contact dermatitis of the water solubilized 1'-Acetoxychavicol Acetate (ACA) by complexation with β-1,3-glucan isolated form Aureobasidium pullulans black yeast is reported. It is well-known that ACA possesses a function to inhibit the activation of NF-κB by which genes encoding proinflammatory cytokines, chemokines, and growth factors are regulated. However, because ACA is quite insoluble in water, its usefulness has been extremely limited. On the other hand, a triple-helical polysaccharide β-1,3-glucan can include hydrophobic compounds into intrastrand hydrophobic cavity and solubilize poorly water-soluble compounds. In this study, solubilization of ACA by complexation with highly branched β-1,3-glucan was achieved. The effect of anti-inflammatory response of water-soluble ACA complex with β-1,3-glucan was confirmed in vitro and in vivo.
authors: Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors: Jiawei
authors: J
authors: Li
authors: Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors: Yui
authors: Y
authors: Aizawa
authors: Department of Biochemistry and Molecular Pathology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors: Keiichi
authors: K
authors: Hiramoto
authors: Department of Biochemistry and Molecular Pathology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors: Emiko
authors: E
authors: Kasahara
authors: Department of Dermatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors: Daisuke
authors: D
authors: Tsuruta
authors: Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors: Toshio
authors: T
authors: Suzuki
authors: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan.
authors: Atsushi
authors: A
authors: Ikeda
authors: Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors: Hideki
authors: H
authors: Azuma
authors: Department of Applied Chemistry & Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. Electronic address: nagasaki@bioa.eng.osaka-cu.ac.jp.
authors: Takeshi
authors: T
authors: Nagasaki
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001592:Benzyl Alcohols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D016207:Cytokines / Q000097:blood; D003877:Dermatitis, Contact / Q000097:blood / Q000188:drug therapy*; D004139:Dinitrofluorobenzene; D004355:Drug Stability; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D012995:Solubility; D012996:Solutions; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014867:Water; D047071:beta-Glucans / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D001592:Benzyl Alcohols; D016207:Cytokines; D008070:Lipopolysaccharides; D016328:NF-kappa B; D009566:Nitrates; D009573:Nitrites; D012996:Solutions; D014409:Tumor Necrosis Factor-alpha; D047071:beta-Glucans; D014867:Water; C033363:beta-1,3-glucan; D004139:Dinitrofluorobenzene; C047948:1'-acetoxychavicol acetate
keywords: Anti-inflammatory effect; Contact dermatitis; Dectin-1; Drug delivery; β-1,3-glucan