title: Potential effector and immunoregulatory functions of mast cells in mucosal immunity.
abstract: Mast cells (MCs) are cells of hematopoietic origin that normally reside in mucosal tissues, often near epithelial cells, glands, smooth muscle cells, and nerves. Best known for their contributions to pathology during IgE-associated disorders such as food allergy, asthma, and anaphylaxis, MCs are also thought to mediate IgE-associated effector functions during certain parasite infections. However, various MC populations also can be activated to express functional programs--such as secreting preformed and/or newly synthesized biologically active products--in response to encounters with products derived from diverse pathogens, other host cells (including leukocytes and structural cells), damaged tissue, or the activation of the complement or coagulation systems, as well as by signals derived from the external environment (including animal toxins, plant products, and physical agents). In this review, we will discuss evidence suggesting that MCs can perform diverse effector and immunoregulatory roles that contribute to homeostasis or pathology in mucosal tissues.
authors: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
authors: L L
authors: LL
authors: Reber
authors: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
authors: R
authors: R
authors: Sibilano
authors: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
authors: K
authors: K
authors: Mukai
authors: 1] Department of Pathology, Stanford University School of Medicine, Stanford, California, USA [2] Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.
authors: S J
authors: SJ
authors: Galli
mesh_terms: D000707:Anaphylaxis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D005512:Food Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D018928:Immunity, Mucosal; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D013045:Species Specificity
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E