title: Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials.
abstract: Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties in vitro and in vivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to in vivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.
authors: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
authors: Livnat
authors: L
authors: Atar-Froyman
authors: Department of Maxillofacial Prosthetics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
authors: Anat
authors: A
authors: Sharon
authors: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
authors: Ervin I
authors: EI
authors: Weiss
authors: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
authors: Yael
authors: Y
authors: Houri-Haddad
authors: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
authors: Dana
authors: D
authors: Kesler-Shvero
authors: Department of Medicinal Chemistry and Natural Products, Hebrew University-Hadassah, School of Pharmacy-Faculty of Medicine, P.O. Box 12065, Jerusalem 91120, Israel.
authors: Abraham J
authors: AJ
authors: Domb
authors: Department of Prosthetic Dentistry, Goldschleger School of Dental Medicine, Tel-Aviv University, Israel.
authors: Raphael
authors: R
authors: Pilo
authors: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel. Electronic address: nuritb@ekmd.huji.ac.il.
authors: Nurit
authors: N
authors: Beyth
mesh_terms: D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001458:Bandages; D001672:Biocompatible Materials / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002412:Cations; D002460:Cell Line; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry; D011094:Polyethyleneimine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D002412:Cations; D000644:Quaternary Ammonium Compounds; D011094:Polyethyleneimine
keywords: Antibacterial; Maxillectomy; Nanoparticles; Polyethylenimine; Post-surgery