title: Oral leukoplakia in patients with Fanconi anaemia without hematopoietic stem cell transplantation.
abstract: BACKGROUND
  Fanconi anaemia is a genetic disease characterized by congenital abnormalities, progressive bone marrow failure, and a higher predisposition of oral squamous cell carcinoma. The purpose of this study was to evaluate the prevalence of oral mucosa lesions in patients with Fanconi anaemia without hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  Patients with Fanconi anaemia who had not undergone HSCT was cross-sectional evaluated for the presence of oral lesions.
  
  
  RESULTS
  The sample was composed of 78 male and 60 female patients, with a median age of 9 years. Of the 138 patients, approximately 45% manifested at least one oral mucosa abnormality: 35 patients (25%) presented with traumatic injuries, and 16 (12%) exhibited leukoplakia. The following lesions were observed in low prevalence: aphthous ulcers, atrophic tongue, petechiae and hematomas, gingival hyperplasia, mucoceles, herpes, hyperpigmentation, haemangioma, non-neoplastic proliferative lesions, neutropenic ulcers, papilloma, and candidiasis.
  
  
  CONCLUSIONS
  There was a high prevalence of oral leukoplakias in patients with Fanconi anaemia who had not undergone HSCT. It highlights the need of regular oral screenings in this cohort of concern for head and neck malignancies and suggests that oral leukoplakias should be further investigated as part of the syndrome phenotype.
authors: Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
authors: Laura
authors: L
authors: Grein Cavalcanti
authors: Karine Fátima
authors: KF
authors: Lyko
authors: Renata Lins Fuentes
authors: RL
authors: Araújo
authors: José Miguel
authors: JM
authors: Amenábar
authors: Carmem
authors: C
authors: Bonfim
authors: Cassius Carvalho
authors: CC
authors: Torres-Pereira
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007972:Leukoplakia, Oral / Q000453:epidemiology*; D008297:Male; D015995:Prevalence
keywords: Fanconi anaemia; diagnostics; oncology; oral cancer; oral manifestations