title: Drug-eluting stent thrombosis in the treatment of chronic total coronary occlusions: incidence, presentation and related factors. Data from the CIBELES trial.
abstract: OBJECTIVE
  The aim of this study was to analyze the incidence of drug-eluting stent thrombosis (sirolimus or everolimus) in patients with chronic total coronary occlusions (CTO) and to determine its clinical implications and related factors.
  
  
  METHODS
  Data from the 12-month follow-up of the 207 patients included in the CIBELES trial with CTO were analyzed.
  
  
  RESULTS
  Stent thrombosis occurred in three patients, two definite and one probable (overall thrombosis rate: 1.4%). However, there were no cases of death or Q-wave myocardial infarction. In univariate analysis, patients with a higher incidence of stent thrombosis were those in whom the target vessel was the left anterior descending, who had single-vessel disease, were assigned to treatment with sirolimus-eluting stents, and those with smaller minimum luminal diameter immediately after the procedure. In multivariate analysis, the only independent predictor of stent thrombosis was minimal luminal diameter immediately after the procedure.
  
  
  CONCLUSIONS
  The rate of drug-eluting stent thrombosis in patients with CTO is relatively low (1.4%). The only independent predictor of stent thrombosis in this context was minimal luminal diameter after the procedure and the clinical presentation was in all cases relatively benign.
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Eduardo
authors: E
authors: Arroyo-Úcar
authors: Hospital Universitario La Paz, Madrid, Spain. Electronic address: raulmorenog@hotmail.com.
authors: Raul
authors: R
authors: Moreno
authors: Hospital Clinico, Madrid, Spain.
authors: Eulogio
authors: E
authors: García
authors: Hospital de Santa Cruz, Lisbon, Portugal.
authors: Rui
authors: R
authors: Teles
authors: Hospital de Galdakao, Bilbao, Spain.
authors: Jose-Ramon
authors: JR
authors: Rumoroso
authors: Hospital de Santo Antonio, Porto, Portugal.
authors: Henrique Cyrne
authors: HC
authors: Carvalho
authors: Hospital Puerta de Hierro, Majadahonda, Spain.
authors: Francisco Javier
authors: FJ
authors: Goicolea
authors: Hospital Virgen de la Salud, Toledo, Spain.
authors: José
authors: J
authors: Moreu
authors: Hospital German Trias I Pujol, Badalona, Spain.
authors: Josefa
authors: J
authors: Mauri
authors: Hospital Santa Creu I Sant Pau, Barcelona, Spain.
authors: Manel
authors: M
authors: Sabaté
authors: Hospital General, Alicante, Spain.
authors: Vicente
authors: V
authors: Mainar
authors: Hospital de Santa Marta, Lisboa, Portugal.
authors: Lino
authors: L
authors: Patricio
authors: Hospital Virgen de la Arrixaca, Murcia, Spain.
authors: Mariano
authors: M
authors: Valdés
authors: Complejo Hospitalario, León, Spain.
authors: Felipe
authors: F
authors: Fernández-Vázquez
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Angel
authors: A
authors: Sánchez-Recalde
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Guillermo
authors: G
authors: Galeote
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Santiago
authors: S
authors: Jimenez-Valero
authors: Hospital de Santa Cruz, Lisbon, Portugal.
authors: Manuel
authors: M
authors: Almeida
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Esteban
authors: E
authors: López de Sa
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Luis
authors: L
authors: Calvo
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Ignacio
authors: I
authors: Plaza
authors: Hospital Universitario La Paz, Madrid, Spain.
authors: Jose-Luis
authors: JL
authors: Lopez-Sendón
authors: Research Manager, School of Biomedical and Health Sciences, Universidad Europea de Madrid, Spain.
authors: Jose-Luis R
authors: JL
authors: Martín
mesh_terms: D000368:Aged; D002908:Chronic Disease; D054059:Coronary Occlusion / Q000188:drug therapy*; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology*; D020123:Sirolimus / Q000008:administration & dosage*; D013927:Thrombosis / Q000175:diagnosis* / Q000453:epidemiology*
chemical_list: D000068338:Everolimus; D020123:Sirolimus
keywords: Chronic total coronary occlusion; Everolimus; Oclusão coronária crónica total; Sirolimus; Stent; Thrombosis; Trombose