title: Delayed cardiac dysrhythmias after fingolimod administration.
abstract: A 51-year-old woman with relapsing-remitting multiple sclerosis was initiated on fingolimod. She developed a Mobitz Type I (Wenckebach)second-degree atrioventricular (AV) heart block during the initial 6-hour monitoring. She was transferred to the emergency department for further monitoring, where she went into a junctional tachycardia then went back into a Mobitz Type I AV block. The patient was symptomatic with a heart rate nadir of 38 beats per minute and treated with atropine. Junctional tachycardia has not been previously reported with fingolimod use. Patients may require extended cardiac monitoring after fingolimod administration.
authors: Department of Pharmacy, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, DE, 19718 USA. Electronic address: jrosini@christianacare.org.
authors: Jamie M
authors: JM
authors: Rosini
authors: Department of Pharmacy, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, DE, 19718 USA. Electronic address: suraj726@gmail.com.
authors: Suraj
authors: S
authors: Rajasimhan
authors: Department of Pharmacy, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, DE, 19718 USA. Electronic address: sfellows11@gmail.com.
authors: Shawn E
authors: SE
authors: Fellows
authors: Department of Emergency Medicine, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, DE, 19718 USA. Electronic address: jnomura@christianacare.org.
authors: Jason T
authors: JT
authors: Nomura
mesh_terms: D054537:Atrioventricular Block / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008875:Middle Aged; D011409:Propylene Glycols / Q000009:adverse effects*; D013110:Sphingosine / Q000009:adverse effects / Q000031:analogs & derivatives*; D013613:Tachycardia, Ectopic Junctional / Q000139:chemically induced* / Q000175:diagnosis; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine