title: The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture.
abstract: BACKGROUND
  Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture.
  
  
  METHODS
  In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay.
  
  
  RESULTS
  The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug.
  
  
  CONCLUSIONS
  The results of this study revealed ACV-N have a higher antiviral activity compared with free drug; it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections.
authors: 1. PhD, Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. hrmonavari@yahoo.com.
authors: Seyed Hamidreza
authors: SH
authors: Monavari
authors: 2. MS, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran. mparsa1389@gmail.com.
authors: Mohammad Javad
authors: MJ
authors: Mirzaei Parsa
authors: 3. PhD, School of Advanced Medical Technologies, Iran University of Medical Sciences, Tehran, Iran. tankbolouri@yahoo.com.
authors: Bahram
authors: B
authors: Bolouri
authors: 4. PhD, Department of Pharmacology, School of Medicine, Iran University of Medical Scinces, Tehran, Iran. ebrahimi@iums.ac.ir.
authors: Soltan Ahmed
authors: SA
authors: Ebrahimi
authors: 5. PhD, Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. gila@inbox.com.
authors: Angila
authors: A
authors: Ataei-Pirkooh
keywords: Cytotoxicity; Herpes simplex virus; Nano-niosomes