title: High prevalence of human herpesvirus type 8 infection in patients with pulmonary tuberculosis in Taiwan.
abstract: Blood samples were collected from 101 untreated pulmonary tuberculosis (TB) patients and 101 age- and sex-matched healthy control subjects. TB patients had lower lymphocyte and a higher monocyte counts than control subjects (p <0.0001 for both). The seropositive rate of human herpesvirus (HHV) type 8 antibody was higher in patients (30/101) than in control subjects (15/101) (p = 0.01). Antibody titres in patients also exceeded those in control subjects (p 0.006). Lymphocyte and monocyte counts between seronegative and seropositive subjects were not different. Four patients were positive for HHV-8 DNA. The study revealed a significantly higher HHV-8 seroprevalence in untreated pulmonary TB patients than in general population.
authors: Institute of Medical Sciences, Tzu Chi University, Taiwan; Departments of Laboratory Medicine and Pathology, Taiwan; Departments of Clinical Pathology and Anatomic Pathology, Taiwan. Electronic address: sucpo@yahoo.com.tw.
authors: C-C
authors: CC
authors: Su
authors: School of Medicine, Tzu Chi University, Taiwan; Division of Pulmonary and Critical Care, Department of Internal Medicine, Taiwan.
authors: C-L
authors: CL
authors: Lai
authors: Institute of Microbiology and Immunology, and Sections of Infectious Diseases and Chest Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: S-M
authors: SM
authors: Tsao
authors: Department of Family Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan.
authors: M-N
authors: MN
authors: Lin
authors: Institute of Medical Sciences, Tzu Chi University, Taiwan.
authors: T-C
authors: TC
authors: Hsieh
authors: Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
authors: J-J
authors: JJ
authors: Lu
authors: Institute of Medical Sciences, Tzu Chi University, Taiwan; Department of Obstetrics and Gynecology, Buddhist Tzu Chi Medical Center, Hualien, Taiwan. Electronic address: hidrchu@gmail.com.
authors: T-Y
authors: TY
authors: Chu
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D060085:Coinfection; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000145:classification / Q000235:genetics / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000276:immunology; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral
keywords: HHV-8; HIV; Kaposi sarcoma; immunofluorescence assay; tuberculosis