title: Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy.
abstract: There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Dong Hyuk
authors: DH
authors: Park
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Sul A
authors: SA
authors: Lee
authors: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors: Hyeon Joo
authors: HJ
authors: Jeong
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Tae-Hyun
authors: TH
authors: Yoo
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Shin-Wook
authors: SW
authors: Kang
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ohjmd@yuhs.ac.
authors: Hyung Jung
authors: HJ
authors: Oh
mesh_terms: D000368:Aged; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D004487:Edema / Q000209:etiology; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D009325:Nausea / Q000209:etiology; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology; D011507:Proteinuria; D012074:Remission Induction; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014396:Tuberculosis, Pleural / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin
keywords: Minimal change disease; rifampicin; steroid