title: Total syntheses and biological evaluation of miuraenamides.
abstract: The miuraenamides, relatively simple representatives of a class of cyclodepsipeptides with high antitumor activity, can be easily and flexibly obtained by the concept of peptide modification. A reaction sequence consisting of an aldol reaction, oxidation, and methylation of the glycine subunit of the cyclodepsipeptides allows the incorporation of the unusual α,β-unsaturated dehydroamino acid in one of the last steps of the synthesis.
authors: Institute for Organic Chemistry, Saarland University, P.O. box 151150, 66041 Saarbrücken (Germany) http://www.uni-saarland.de/lehrstuhl/kazmaier.
authors: Lisa
authors: L
authors: Karmann
authors: Katharina
authors: K
authors: Schultz
authors: Jennifer
authors: J
authors: Herrmann
authors: Rolf
authors: R
authors: Müller
authors: Uli
authors: U
authors: Kazmaier
mesh_terms: D000199:Actins / Q000378:metabolism / Q000648:ultrastructure; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D000199:Actins; D000970:Antineoplastic Agents; D047630:Depsipeptides; C514528:miuraenamide A
keywords: actin-binding compounds; antitumor activity; cyclodepsipeptides; miuraenamides; natural products