title: Grey matter volume differences in non-affective psychosis and the effects of age of onset on grey matter volumes: A voxelwise study.
abstract: Previous evidence indicates that structural brain alterations are already present in the early phases of psychosis. In this study we aim to investigate the relationships among the different diagnoses in the spectrum of non-affective psychosis. A hundred-and-one first-episode psychosis patients (FEP) and 69 healthy volunteers, matched for age, gender, handedness and educational level were analyzed by structural MRI and high-dimensional voxel-based morphometry as implemented in SPM8 software. We obtained three main results: (1) FEP patients showed reduction of grey matter volume (GMV) in the frontal, temporal and occipital lobes, left insula and cerebellum. (2) Age of disease onset was an important factor revealing a gradual decrease of GMV (healthy controls>late onset>intermediate onset>early onset) in the frontal, temporal and occipital lobes, insula and cerebellum. (3) A gradual reduction of GMV related to diagnosis spectrum in the frontal, temporal, parietal and occipital lobes of schizophrenia patients being the most affected. These results suggest that an earlier onset of psychosis is linked to an earlier disease-related disruption of structural brain development, which may be most pronounced in schizophrenia compared to other psychoses.
authors: Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, Spain; CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain. Electronic address: diana.tordesillas@humv.es.
authors: Diana
authors: D
authors: Tordesillas-Gutierrez
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Bavaria, Germany.
authors: Nikolaos
authors: N
authors: Koutsouleris
authors: CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
authors: Roberto
authors: R
authors: Roiz-Santiañez
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Bavaria, Germany.
authors: Eva
authors: E
authors: Meisenzahl
authors: CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
authors: Rosa
authors: R
authors: Ayesa-Arriola
authors: Department of Radiology, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors: Enrique
authors: E
authors: Marco de Lucas
authors: CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain; Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Spain.
authors: Carles
authors: C
authors: Soriano-Mas
authors: CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
authors: Paula
authors: P
authors: Suarez-Pinilla
authors: CIBERSAM, Centro Investigación Biomédica en Red de Salud Mental, Spain; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
authors: Benedicto
authors: B
authors: Crespo-Facorro
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: Age of onset; First-episode; Psychosis; Schizophrenia; Voxel-based morphometry