title: Psychophysiological Correlates of Developmental Changes in Healthy and Autistic Boys.
abstract: This study investigated neurodevelopmental changes in sound processing by recording mismatch negativity (MMN) in response to various degrees of sound complexity in 18 mildly to moderately autistic versus 15 healthy boys aged between 6 and 15 years. Autistic boys presented with lower IQ and poor performance on a range of executive and social function measures when compared to their healthy counterparts. We found that MMN in response to duration deviants was less lateralized in the clinical group whereas larger amplitudes correlated with advanced age, thus capturing neurodevelopmental changes. Larger MMN in response to speech-like sound deviants was associated with better verbal fluency and executive function performance, respectively, but did not reliably discriminate the two groups.
authors: Priority Centre for Translational Neuroscience and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.
authors: Benjamin
authors: B
authors: Weismüller
authors: Renate
authors: R
authors: Thienel
authors: Anne-Marie
authors: AM
authors: Youlden
authors: Ross
authors: R
authors: Fulham
authors: Michael
authors: M
authors: Koch
authors: Ulrich
authors: U
authors: Schall
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D001321:Autistic Disorder / Q000503:physiopathology* / Q000523:psychology*; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D056344:Executive Function; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests