title: Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity.
abstract: Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer. QA-PDEAEM NPs of 50-70 nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C8 and N-C18 alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria.
authors: Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience & Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
authors: Shady
authors: S
authors: Farah
authors: Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience & Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Oren
authors: O
authors: Aviv
authors: Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Natalia
authors: N
authors: Laout
authors: Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Stanislav
authors: S
authors: Ratner
authors: Department of Prosthodontics, Faculty of Dentistry, The Hebrew University-Hadassah, Jerusalem 91120, Israel.
authors: Nurit
authors: N
authors: Beyth
authors: Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience & Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address: avid@ekmd.huji.ac.il.
authors: Abraham J
authors: AJ
authors: Domb
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D052836:Heterotrophic Processes / Q000187:drug effects; D008689:Methacrylates / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D058105:Polymerization; D011145:Polyvinyls / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D011145:Polyvinyls; D000644:Quaternary Ammonium Compounds; C016438:ethylenevinylacetate copolymer; C519537:diethylaminoethyl methacrylate
keywords: Antimicrobial nanoparticles; Antimicrobial surfaces; Diethylaminoethyl methacrylate; Quaternary ammonium (QA) polymers