title: ATM protein kinase signaling, type 2 diabetes and cardiovascular disease.
abstract: The ataxia-telangiectasia mutated (ATM) protein kinase is well known to play a significant role in the response to double stranded DNA breaks in the nucleus. Recently, it has become apparent that ATM is also involved in a large number of cytoplasmic processes and responses, some of which may contribute to metabolic and cardiovascular complications when disrupted. Due to its involvement in these processes, therapeutic activation of ATM could potentially be a novel approach for the prevention or treatment of cardiovascular disease. However, relatively little is currently known about the cardiovascular role of ATM. In this review, we highlight studies that have shed some light on the role of ATM in the cardiovascular context, namely in oxidative stress, atherosclerosis and metabolism, insulin resistance and cardiac remodeling.
authors: Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa, yespach1@gmail.com.
authors: Yolandi
authors: Y
authors: Espach
authors: Amanda
authors: A
authors: Lochner
authors: Hans
authors: H
authors: Strijdom
authors: Barbara
authors: B
authors: Huisamen
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D064007:Ataxia Telangiectasia Mutated Proteins