title: Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  After PCOS model was formed by subcutaneous dihydrotestosterone pellets, rats were randomly divided into 2 groups. The first group (n = 7) was treated with 1 mL/kg/d isotonic saline and the second group (n = 7) was treated with 10 mg/kg/d resveratrol. Seven rats were taken as controls without any medication.
  
  
  RESULTS
  Our results showed (1) significant reduction in the number of antral follicle counts (P < .01); (2) significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (P < .01 and P < .05, respectively); (3) significantly lower superoxide dismutase activity (P < .05); and (4) significantly increased glutathione peroxidase content (P < .01) following resveratrol treatment.
  
  
  CONCLUSIONS
  Resveratrol appears to be effective in the treatment of PCOS due to its antioxidant properties. Future clinical studies with different dosages might provide useful implementations to our practice.
authors: Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
authors: Mete
authors: M
authors: Ergenoglu
authors: Department of Obstetrics and Gynecology, Dokuz Eylul University, Izmir, Turkey Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey nuri-yildirim@hotmail.com nuri.yildirim@deu.edu.tr.
authors: Nuri
authors: N
authors: Yildirim
authors: Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
authors: Alkim Gulsah Sahingoz
authors: AG
authors: Yildirim
authors: Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
authors: Ozgur
authors: O
authors: Yeniel
authors: Department of Physiology, Ege University, Izmir, Turkey.
authors: Oytun
authors: O
authors: Erbas
authors: Department of Histology and Embryology, Ege University, Izmir, Turkey.
authors: Altug
authors: A
authors: Yavasoglu
authors: Department of Physiology, Ege University, Izmir, Turkey.
authors: Dilek
authors: D
authors: Taskiran
authors: Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
authors: Nedim
authors: N
authors: Karadadas
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone / Q000097:blood*; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D013196:Dihydrotestosterone; D004195:Disease Models, Animal; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013267:Stilbenes; C548904:insulin-like growth factor-1, rat; D013196:Dihydrotestosterone; D007334:Insulin-Like Growth Factor I; D054304:Anti-Mullerian Hormone; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077185:Resveratrol
keywords: anti-Mullerian hormone; oxidative stress; polycystic ovary syndrome; rat model; resveratrol