title: A multiple gadolinium complex decorated fullerene as a highly sensitive T(1) contrast agent.
abstract: We report a simple strategy to construct a multiple gadolinium complex decorated fullerene (CGDn) as an enhanced T1 contrast agent. The CGDn exhibits much higher T1 relaxivity (∼49.7 mM(-1) s(-1)) than individual Gd-DOTA, and shows excellent T1 contrast enhancement ability both in vitro and in vivo.
authors: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn.
authors: Lirong
authors: L
authors: Wang
authors: Xianglong
authors: X
authors: Zhu
authors: Xingyan
authors: X
authors: Tang
authors: Changqiang
authors: C
authors: Wu
authors: Zijian
authors: Z
authors: Zhou
authors: Chengjie
authors: C
authors: Sun
authors: Shun-Liu
authors: SL
authors: Deng
authors: Hua
authors: H
authors: Ai
authors: Jinhao
authors: J
authors: Gao
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006321:Heart / Q000000981:diagnostic imaging; D006571:Heterocyclic Compounds / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000737:chemistry; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D037741:Fullerenes; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium