title: Puupehenol, a potent antioxidant antimicrobial meroterpenoid from a Hawaiian deep-water Dactylospongia sp. sponge.
abstract: From the organic extract of a deep-water Hawaiian sponge Dactylospongia sp., a new potent antioxidant and antimicrobial meroterpenoid, puupehenol (1), was isolated. The structure of 1 was determined using spectroscopic techniques ((1)H and (13)C NMR, MS, IR, UV, [α]D). The known compound puupehenone (2) was also isolated and suggested as a probable artifact of the isolation procedures. Complete unambiguous (1)H and (13)C NMR data are provided for compounds 1 and 2. Bioassays performed with 1 and 2 showed them both to be very effective antioxidants and to have antimicrobial properties.
authors: DKI College of Pharmacy, University of Hawaii at Hilo , Hilo, Hawaii 96720, United States.
authors: Kehau
authors: K
authors: Hagiwara
authors: Jaaziel E
authors: JE
authors: Garcia Hernandez
authors: Mary Kay
authors: MK
authors: Harper
authors: Anthony
authors: A
authors: Carroll
authors: Cherie A
authors: CA
authors: Motti
authors: Jonathan
authors: J
authors: Awaya
authors: Hoang-Yen
authors: HY
authors: Nguyen
authors: Anthony D
authors: AD
authors: Wright
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006254:Hawaii; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D044004:Xanthones
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D012717:Sesquiterpenes; D044004:Xanthones; C000600374:puupehenol; C053594:puupehenone