title: Renal denervation for resistant hypertension.
abstract: There is a marked contrast between the high prevalence of hypertension and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases.
authors: Serviço de Cardiologia, Hospital de Santa Cruz - CHLO, Carnaxide, Portugal.
authors: Manuel de Sousa
authors: Mde S
authors: Almeida
authors: Serviço de Cardiologia, Hospital de Santa Cruz - CHLO, Carnaxide, Portugal; Departamento de Fisiopatologia, Faculdade de Ciências Médicas, UNL, Lisboa, Portugal. Electronic address: paraujogoncalves@yahoo.co.uk.
authors: Pedro de Araújo
authors: Pde A
authors: Gonçalves
authors: Serviço de Cardiologia, Hospital de Santa Maria, CHLN, Lisboa, Portugal; Instituto de Fisiologia, Faculdade de Medicina de Lisboa, UL, Lisboa, Portugal.
authors: Eduardo Infante de
authors: EI
authors: Oliveira
authors: Serviço de Cardiologia, Hospital de Santo Antonio, CHP, Portugal; Unidade Curricular de Medicina I, Instituto de Ciências Biomédicas Abel Salazar, UP, Porto, Portugal.
authors: Henrique Cyrne de
authors: HC
authors: Carvalho
mesh_terms: D002986:Clinical Trials as Topic; D003329:Coronary Vasospasm / Q000150:complications / Q000601:surgery*; D005544:Forecasting; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery*; D013562:Sympathectomy
keywords: Desnervação renal; Hipertensão arterial; Hypertension; Renal denervation; Sistema nervoso simpático; Sympathetic nervous system