title: Radiobiological treatment planning evaluation of inverse planning simulated annealing for cervical cancer high-dose-rate brachytherapy.
abstract: OBJECTIVE
  To compare five inverse treatment plans with one conventional manually-optimized plan for cervical cancer brachytherapy (BT) using radiobiological parameters combined with dosimetric and volumetric parameters.
  
  
  METHODS
  Five inverse treatment plans were calculated using an inverse planning simulated annealing (IPSA) algorithm for each of four fractions for 12 cervical cancer patients treated with high-dose-rate (HDR) brachytherapy. The inverse treatment plans were compared to a manually-optimized plan used for the actual treatment of the patients. The comparison of the plans was performed with respect to the probability of cure without complication (P+).
  
  
  RESULTS
  Overall, the manually optimized plan scored the best results; however, the probability of cure without complication is within an acceptable clinical range for all the plans.
  
  
  CONCLUSIONS
  Although there are still considerable uncertainties in the radiobiological parameters, the radiobiological plan evaluation method presents itself as a potential complement to physical dosimetric methods.
authors: Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
authors: Tomas
authors: T
authors: Palmqvist
authors: Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden Department of Physics, Eduardo Mondlane University, Maputo, Mozambique Lucilio.Matias@ki.se.
authors: Lucílio
authors: L
authors: Dos S Matias
authors: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
authors: Anne B L
authors: AB
authors: Marthinsen
authors: Women's Clinic, St. Olav's Hospital, Trondheim, Norway.
authors: Marit
authors: M
authors: Sundset
authors: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
authors: Anne D
authors: AD
authors: Wanderås
authors: Clinic of Oncology, St. Olav's Hospital, Trondheim, Norway.
authors: Signe
authors: S
authors: Danielsen
authors: Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden.
authors: Iuliana
authors: I
authors: Toma-Dasu
mesh_terms: D000465:Algorithms; D001918:Brachytherapy; D005260:Female; D006801:Humans; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
keywords: Brachytherapy; IPSA; radiobiological evaluation