title: Stimulating high impact HIV-related cardiovascular research: recommendations from a multidisciplinary NHLBI Working Group on HIV-related heart, lung, and blood disease.
abstract: The clinical challenges confronting patients with human immunodeficiency virus (HIV) have shifted from acquired immunodeficiency syndrome (AIDS)-related illnesses to chronic diseases, such as coronary artery disease, chronic lung disease, and chronic anemia. With the growing burden of HIV-related heart, lung, and blood (HLB) disease, the National Heart, Lung, and Blood Institute (NHLBI) recognizes it must stimulate and support HIV-related HLB research. Because HIV offers a natural, accelerated model of common pathological processes, such as inflammation, HIV-related HLB research may yield important breakthroughs for all patients with HLB disease. This paper summarizes the cardiovascular recommendations of an NHLBI Working Group, Advancing HIV/AIDS Research in Heart, Lung, and Blood Diseases, charged with identifying scientific priorities in HIV-related HLB disease and developing recommendations to promote multidisciplinary collaboration among HIV and HLB investigators. The working group included multidisciplinary sessions, as well as HLB breakout sessions for discussion of disease-specific issues, with common themes about scientific priorities and strategies to stimulate HLB research emerging in all 3 groups.
authors: National Heart, Lung, and Blood Institute, Bethesda, Maryland. Electronic address: shahmr@nhlbi.nih.gov.
authors: Monica R
authors: MR
authors: Shah
authors: National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Nakela
authors: N
authors: Cook
authors: National Heart, Lung, and Blood Institute, Bethesda, Maryland.
authors: Renee
authors: R
authors: Wong
authors: Division of Cardiology, University of California-San Francisco School of Medicine, San Francisco, California.
authors: Priscilla
authors: P
authors: Hsue
authors: Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard University School of Medicine, Boston, Massachusetts.
authors: Paul
authors: P
authors: Ridker
authors: Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California.
authors: Judith
authors: J
authors: Currier
authors: National Cancer Institute, Bethesda, Maryland.
authors: Susan
authors: S
authors: Shurin
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration*; D002318:Cardiovascular Diseases / Q000150:complications* / Q000628:therapy*; D002985:Clinical Protocols; D015658:HIV Infections / Q000150:complications* / Q000628:therapy*; D006292:Health Priorities; D006801:Humans; D054555:National Heart, Lung, and Blood Institute (U.S.); D014481:United States
keywords: acquired immunodeficiency syndrome; cardiovascular disease; coronary artery disease; disease progression; inflammation; risk factors