title: Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
abstract: A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.
authors: Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
authors: Linh H
authors: LH
authors: Mai
authors: Laboratoire de Pharmacologie Chimique, Génétique et Imagerie U1022 Inserm-UMR8151 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
authors: Guy G
authors: GG
authors: Chabot
authors: Muséum National d'Histoire Naturelle, UMR 7245 CNRS, Molécules de Communication et Adaptation des Micro-organismes, 61 rue Buffon, F-75231 Paris Cedex 05, France.
authors: Philippe
authors: P
authors: Grellier
authors: Laboratoire de Pharmacologie Chimique, Génétique et Imagerie U1022 Inserm-UMR8151 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
authors: Lionel
authors: L
authors: Quentin
authors: Centre de recherche de Gif, Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Avenue de la Terrasse, Gif-sur-Yvette Cedex, France.
authors: Vincent
authors: V
authors: Dumontet
authors: Centre de recherche de Gif, Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Avenue de la Terrasse, Gif-sur-Yvette Cedex, France.
authors: Cyril
authors: C
authors: Poulain
authors: Laboratorio de Farmacognosia, Universidade de Brasilia, Campus Universitario Darcy Ribeiro, Asa Norte, 70910-900 Brasilia, DF, Brazil.
authors: Laila S
authors: LS
authors: Espindola
authors: Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
authors: Sylvie
authors: S
authors: Michel
authors: Faculty of Pharmacy, Ho Chi Minh University of Medicine and Pharmacy, 41 Dinh Tien Hoang St., District 1, Ho Chi Minh City, Viet Nam.
authors: Hue T B
authors: HT
authors: Vo
authors: Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
authors: Brigitte
authors: B
authors: Deguin
authors: Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France. Electronic address: raphael.grougnet@parisdescartes.fr.
authors: Raphaël
authors: R
authors: Grougnet
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D032062:Gardenia / Q000737:chemistry*; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D009510:New Caledonia; D010936:Plant Extracts / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship; D014347:Trypanosoma brucei gambiense / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D000977:Antiparasitic Agents; D005419:Flavonoids; D010936:Plant Extracts
keywords: Antileishmanial; Antiplasmodial; Antivascular agents; Endothelial cells; Flavonoids; Trypanocidal