title: The genetics of alopecia areata: new approaches, new findings, new treatments.
abstract: Alopecia areata (AA) is a common immune-mediated hair loss disorder. Despite its high prevalence, its etiology is still largely unknown, but it is hypothesized to have a strong genetic basis. In the last decade, there has been a major progress in the field of genetic research, leading to novel findings regarding the genetic component of AA. The aim of this review is to summarize the information collected so far in this field, the basic principles of the genetic methods used in previous studies, and new therapeutic strategies that might become available in light of the new findings.
authors: Department of Dermatology, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem 9112001, Israel.
authors: Roni
authors: R
authors: Biran
authors: Department of Dermatology, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem 9112001, Israel.
authors: Abraham
authors: A
authors: Zlotogorski
authors: Department of Dermatology, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem 9112001, Israel. Electronic address: yramot@gmail.com.
authors: Yuval
authors: Y
authors: Ramot
mesh_terms: D000506:Alopecia Areata / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D000818:Animals; D015551:Autoimmunity / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D010641:Phenotype; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics
chemical_list: D005819:Genetic Markers
keywords: Alopecia; Alopecia areata; GWAS; Genetics; Hair; Immunology