title: Matrix metalloproteinases in destructive lung disease.
abstract: Matrix metalloproteinases (MMPs) play essential physiologic roles in numerous processes ranging from development to wound repair. Unfortunately, given the broad substrate specificity of the MMP family as a whole, aberrant degradation of extracellular matrix proteins can result in destructive disease. Emphysema, the result of destroyed lung elastin and collagen matrix, is the prototypical example of such a destructive process. More recent data has highlighted that MMPs play much more elaborate physiologic and pathophysiologic roles than simple matrix protein cleavage. Key pathophysiological roles for MMPs in emphysema will be discussed herein.
authors: Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center and Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, United States. Electronic address: Houghton@fredhutch.org.
authors: A McGarry
authors: AM
authors: Houghton
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D011656:Pulmonary Emphysema / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D012907:Smoking / Q000009:adverse effects
chemical_list: D003094:Collagen; D004549:Elastin; D020782:Matrix Metalloproteinases
keywords: elastin; emphysema; matrix metalloproteinases