title: RUNX3 Promoter Methylation Is Associated with Hepatocellular Carcinoma Risk: A Meta-Analysis.
abstract: Runt-related transcription factor 3 (RUNX3) has been reported to be a tumor-suppressing gene in hepatocellular carcinoma. Association between hepatocellular carcinoma and RUNX3 promoter methylation has been investigated in studies with specific ethnic backgrounds and small sample sizes. In this study, a meta-analysis was adopted to combine the data from 11 studies of association between RUNX3 promoter methylation and hepatocellular carcinoma. Pooled odds ratio for RUNX3 promoter methylation status in hepatocellular carcinoma versus control liver tissue was 24.37 (95%CI: 12.14, 48.92), p < .00001, indicates a strong association between methylation of the RUNX3 promoter and hepatocellular carcinoma.
authors: Medical and Nursing School, Chengdu University , Chengdu , China.
authors: Xueyan
authors: X
authors: Zhang
authors: Hairong
authors: H
authors: He
authors: Xu
authors: X
authors: Zhang
authors: Wenjie
authors: W
authors: Guo
authors: Yueqi
authors: Y
authors: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics*; D019175:DNA Methylation; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C493729:Runx3 protein, human
keywords: Confidence intervals; RUNX3; Hepatocellular carcinoma; Meta-Analysis; Methylation; OR; Odds ratio; CI; Promoter; RUNX3; Runt-related transcription factor 3