title: Role of multifunctional Chemerin in obesity and preclinical diabetes.
abstract: BACKGROUND
  "Chemerin" is a multifuntional peptide involved in lipid and glucose metabolism. Elevated levels of this peptide have been associated with insulin resistance and systemic inflammation. This study aims to identify whether Chemerin along with other inflammatory markers (TNFα and hsCRP) can discriminate subjects with subclinical diabetes.
  
  
  RESULTS
  Fifty-two asymptomatic healthy volunteers and 22 chronic diabetics (T2DM) were enrolled in a cross sectional study design. They were subjected to a 75 g oral glucose tolerance test [OGTT (2-h glucose>200 mg/dL)] and were then classified as either newly diagnosed diabetics (NDM) (n=23) or healthy controls (n=29). Our results showed a higher Chemerin level in NDM (p<0.01; MWU) compared to controls and previously diagnosed DM. Using ROC analysis, Chemerin level in NDM and T2DM had AUC of 0.963 and 0.764 respectively, compared to healthy controls. We suggest that the cut off of 13.7 ng/ml of Chemerin can discriminate 73% of NDM subjects with impaired glucose level with 91% and 96% of sensitivity and specificity respectively. Elevated serum Chemerin in NDM group is a surrogate of impairment in glucose metabolism in obese individual.
  
  
  CONCLUSIONS
  Chemerin along with other inflammatory biomarkers suggest an ongoing inflammatory process in a high risk obese group that indicates a pre-diabetic state.
authors: Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
authors: Syeda Sadia
authors: SS
authors: Fatima
authors: Aga Khan University Medical College, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
authors: Zoya
authors: Z
authors: Butt
authors: Aga Khan University Medical College, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
authors: Nimrah
authors: N
authors: Bader
authors: Aga Khan University Medical College, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
authors: Aly Zaheer
authors: AZ
authors: Pathan
authors: Aga Khan University Medical College, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
authors: Sheraz
authors: S
authors: Hussain
authors: Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan; Department of Paediatrics & Child Health, Aga Khan University, Stadium Road, Karachi 74800, Pakistan. Electronic address: najeeha.iqbal@aku.edu.
authors: Najeeha Talat
authors: NT
authors: Iqbal
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D018925:Chemokines / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D011236:Prediabetic State / Q000097:blood* / Q000150:complications; D012372:ROC Curve; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human
keywords: Chemerin; Cytokines; Diabetes; Inflammation; hsCRP