title: Celiac disease causing severe osteomalacia: an association still present in Morocco!
abstract: Celiac disease (CD), a malabsorption syndrome caused by hypersensitivity to gliadin fraction of gluten. CD can manifest with classic symptoms; however, significant myopathy and multiple fractures are rarely the predominant presentation of untreated celiac disease. Osteomalacia complicating celiac disease had become more and more rare. We describe here a case of osteomalacia secondary to a longstanding untreated celiac disease. This patient complained about progressive bone and muscular pain, weakness, fractures and skeletal deformities. Radiological and laboratory findings were all in favor of severe osteomalacia. Improvement of patient's weakness and laboratory abnormalities was obvious after treatment with gluten free diet, vitamin D, calcium and iron. This case affirms that chronic untreated celiac disease, can lead to an important bone loss and irreversible complications like skeletal deformities.
authors: Department of Rheumatology, CHU Hassan II, Fès, Morocco.
authors: Latifa
authors: L
authors: Tahiri
authors: Department of Rheumatology, CHU Hassan II, Fès, Morocco.
authors: Hamida
authors: H
authors: Azzouzi
authors: Department of Rheumatology, CHU Hassan II, Fès, Morocco.
authors: Ghita
authors: G
authors: Squalli
authors: Department of Rheumatology, CHU Hassan II, Fès, Morocco.
authors: Fatimazahra
authors: F
authors: Abourazzak
authors: Department of Rheumatology, CHU Hassan II, Fès, Morocco.
authors: Taoufik
authors: T
authors: Harzy
mesh_terms: D000328:Adult; D002118:Calcium / Q000008:administration & dosage; D002446:Celiac Disease / Q000150:complications* / Q000628:therapy; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D009018:Morocco; D010018:Osteomalacia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012720:Severity of Illness Index; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: D014807:Vitamin D; D007501:Iron; D002118:Calcium
keywords: Morocco; Osteomalacia; bone loss; celiac disease; vitamin D