title: Usefulness of in vivo photodiagnosis for the identification of tumor margins in recurrent basal cell carcinoma of the face.
abstract: BACKGROUND
  Basal cell carcinoma (BCC) is the most frequent malignant tumor of the skin. The high prevalence of BCC, the risk of local recurrence, and the difficult clinical identification of the excision margins emphasize the importance of studying new approaches, ensuring complete surgical excision that allows preservation of normal tissue, especially for BCCs located on cosmetically important areas such as the mid face. Photodiagnosis (PD) is a pre-operative technique that allows a more accurate distinction of neoplastic lesions from surrounding healthy skin in vivo.
  
  
  OBJECTIVE
  The aim of this study is to assess the usefulness of PD for the evaluation of tumor margins in 10 patients with recurrent BCC of the face.
  
  
  METHODS
  We study the red fluorescence emitted by neoplastic tissue under a Wood's lamp irradiation, after accumulation of methyl amino levulinate (MAL) cream in 10 patients with recurrent BCC.
  
  
  RESULTS
  Our histologic analysis of perilesional skin by PD allowed to delineate more precise tumor margins, thus achieving radical excision in 90% of patients.
  
  
  CONCLUSIONS
  PD represents a diagnostic method that helps to distinguish between tumor tissue and surrounding healthy tissue especially in case of recurrent BCC of the face when the clinical delimitation is not clear.
authors: Laboratori Sperimentali di Ricerca - Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Riccardo G
authors: RG
authors: Borroni
authors: Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Stefania
authors: S
authors: Barruscotti
authors: Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Andrea
authors: A
authors: Carugno
authors: Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Vincenzo
authors: V
authors: Barbaccia
authors: Laboratori Sperimentali di Ricerca - Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Eloisa
authors: E
authors: Arbustini
authors: Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Valeria
authors: V
authors: Brazzelli
mesh_terms: D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology*; D005153:Facial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*
keywords: basal cell carcinoma; fluorescence diagnosis; methylaminolevulinate; photodiagnosis