title: Serum NSE level and disability progression in multiple sclerosis.
abstract: BACKGROUND
  Previous studies suggested that serum neuron specific enolase (NSE) may be a biomarker associated with progression in MS.
  
  
  METHODS
  We measured serum NSE levels in 385 patients with multiple sclerosis (MS) (264 with relapsing-remitting (RR) MS, 86 with secondary progressive (SP) MS, and 35 with primary progressive (PP) MS), and compared levels between disease courses, between users and non-users of immunomodulatory treatment, and between patients with worsening or stable disability at one year follow-up (available in 161 patients). We also investigated the correlation between serum NSE and Expanded Disability Status Scale (EDSS) and MS Severity Score (MSSS) scores in the whole cohort and in subgroups, and built a multiple linear regression model to assess the influence of predictor variables on serum NSE.
  
  
  RESULTS
  Age was the only independent predictor of serum NSE levels in the multiple linear regression model. In the subgroup of patients with PPMS, there was a moderate correlation between serum NSE and increasing MSSS (Pearson's r 0.35, p=0.04) and EDSS (Spearman's rho 0.37, p=0.03) scores.
  
  
  CONCLUSIONS
  Our data do not support the use of serum NSE as a prognostic biomarker in RRMS or SPMS. The correlations of serum NSE with EDSS and MSSS in the PPMS subgroup are interesting, but based on a small sample size and require replication in other cohorts.
authors: Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: mwkoch@ucalgary.ca.
authors: Marcus W
authors: MW
authors: Koch
authors: Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors: Suzanne
authors: S
authors: George
authors: Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors: Winona
authors: W
authors: Wall
authors: Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors: V
authors: V
authors: Wee Yong
authors: Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
authors: Luanne M
authors: LM
authors: Metz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004185:Disability Evaluation; D006233:Persons with Disabilities; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis*; D010751:Phosphopyruvate Hydratase / Q000097:blood*
chemical_list: D015415:Biomarkers; D010751:Phosphopyruvate Hydratase
keywords: Biomarker; Disability; Multiple sclerosis; Progression; Progressive MS; Serum biomarker