title: Determination of pesticide residues in milk using a QuEChERS-based method developed by response surface methodology.
abstract: Response surface methodology (RSM) was employed to optimise a rapid and easy sample preparation method for the determination of 14 different pesticide residues in milk. The recovery of each pesticide was investigated by a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe)-based method with respect to 3 variables, the amounts of sodium acetate (Na Acetate), primary secondary amine (PSA), and octadecylsilane (C18). After optimisation, the maximum predicted recovery was the 99.73% rate for myclobutanil under the optimised conditions of 1.70 g Na Acetate, 600.00 mg PSA, and 489.96 mg C18. The recovery rates of the other 9 hydrophilic pesticides were ranged from 82.01% to 98.84%. However, the recovery rates for the 4 lipophilic pesticides (2,4'-DDE, 4,4'-DDE, 2,4'-DDT, and 4,4'-DDT) were <80% because they were removed by C18 along with the other fatty compounds. This method could be implemented in many laboratories to reduce inspection time and cost.
authors: Food Safety Center, Research and Development Institute, Namyang Dairy Co., Ltd., Bongan-Ri 160, Janggi-Myeon, Gongju 314-914, Republic of Korea.
authors: In-Seek
authors: IS
authors: Jeong
authors: Food Safety Center, Research and Development Institute, Namyang Dairy Co., Ltd., Bongan-Ri 160, Janggi-Myeon, Gongju 314-914, Republic of Korea.
authors: Byung-Man
authors: BM
authors: Kwak
authors: Food Safety Center, Research and Development Institute, Namyang Dairy Co., Ltd., Bongan-Ri 160, Janggi-Myeon, Gongju 314-914, Republic of Korea. Electronic address: ppori5470@hotmail.com.
authors: Jang-Hyuk
authors: JH
authors: Ahn
authors: Food Safety Center, Research and Development Institute, Namyang Dairy Co., Ltd., Bongan-Ri 160, Janggi-Myeon, Gongju 314-914, Republic of Korea.
authors: Seung-Hwan
authors: SH
authors: Jeong
mesh_terms: D000818:Animals; D002417:Cattle; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination; D008892:Milk / Q000737:chemistry*; D010573:Pesticide Residues / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*; D013499:Surface Properties
chemical_list: D010573:Pesticide Residues; D010575:Pesticides
keywords: Milk; Pesticide residues; QuEChERS method; Response surface methodology