title: Anti-inflammatory activity of leaf essential oil from Cinnamomum longepaniculatum (Gamble) N. Chao.
abstract: The anti-inflammatory activity of the essential oil from C. longepaniculatum was evaluated by three experimental models including the dimethyl benzene-induced ear edema in mice, the carrageenan-induced paw edema in rat and the acetic acid-induced vascular permeability in mice. The influence of the essential oil on histological changes and prostaglandin E2 (PGE2), histamine and 5-hydroxytryptamine (5-HT) production associated with carrageenan-induced rat paw edema was also investigated. The essential oil (0.5, 0.25, 0.13 ml/kg b.w.) showed significantly inhibition of inflammation along with a dose-dependent manner in the three experimental models. The anti-inflammatory activity of essential oil was occurred both in early and late phase and peaked at 4 h after carrageenan injection. The essential oil resulted in a dose dependent reduction of the paw thickness, connective tissue injury and the infiltration of inflammatory cell. The essential oil also significantly reduced the production of PGE2, histamine and 5-HT in the exudates of edema paw induced by carrageenan. Both the essential oil and indomethacin resulted relative lower percentage inhibition of histamine and 5-HT than that of PGE2 at 4 h after carrageenan injection.
authors: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin 644000, Sichuan, China.
authors: Yong-Hua
authors: YH
authors: Du
authors: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin 644000, Sichuan, China.
authors: Rui-Zhang
authors: RZ
authors: Feng
authors: Sichuan Normal University, College of Life Science Chengdu 610101, Sichuan, China.
authors: Qun
authors: Q
authors: Li
authors: Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin 644000, Sichuan, China.
authors: Qin
authors: Q
authors: Wei
authors: College of Veterinary Medicine Sichuan Agricultural University Ya'an 625014, Sichuan, China.
authors: Zhong-Qiong
authors: ZQ
authors: Yin
authors: Yibin Vocational and Technical College Yibin 644003, Sichuan, China.
authors: Li-Jun
authors: LJ
authors: Zhou
authors: College of Veterinary Medicine Sichuan Agricultural University Ya'an 625014, Sichuan, China.
authors: Cui
authors: C
authors: Tao
authors: College of Veterinary Medicine Sichuan Agricultural University Ya'an 625014, Sichuan, China.
authors: Ren-Yong
authors: RY
authors: Jia
keywords: Cinnamomum longepaniculatum; anti-inflammatory activity; essential oil