title: Analysis of WNT4 polymorphism in Chinese Han women with endometriosis.
abstract: Endometriosis is a complex disease that is influenced by genetic and environmental factors. In endometriosis, WNT4 plays a likely role owing to its biological functions. In this study, the TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single nucleotide polymorphisms in WNT4 (rs7521902 [A/C], rs16826658 [G/T], rs7515106 [C/T] and rs2235529 [A/G]) in Chinese Han women. A total of 646 patients with endometriosis and 766 normal controls were recurited. Regression analyses revealed that rs2235529 was a risk locus for endometriosis (P = 1.80E-03, OR, 95% CI = 1.311, 1.129 to 1.522), particularly in patients with stage III and IV disease. No significant association was found between endometriosis and rs7521902 (A/C), rs16826658 (G/T), or rs7515106 (C/T). For each of the four single nucleotide polymorphisms, no association was found between patients with endometriosis-related infertility or primary infertility and the controls. The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Zhangying
authors: Z
authors: Wu
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Ming
authors: M
authors: Yuan
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Yan
authors: Y
authors: Li
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Fangfang
authors: F
authors: Fu
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Wenqinq
authors: W
authors: Ma
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China.
authors: Haixia
authors: H
authors: Li
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China. Electronic address: wangwenwen1@gmail.com.
authors: Wenwen
authors: W
authors: Wang
authors: Cancer Biology Research Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street 1095#, Wuhan, Hubei 430030, PR China. Electronic address: sxwang2012@hotmail.com.
authors: Shixuan
authors: S
authors: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D060528:Wnt4 Protein / Q000235:genetics*
chemical_list: D060528:Wnt4 Protein
keywords: WNT4; endometriosis; infertility; polymorphism