title: A new highly oxygenated daphnane diterpene esters from the flower buds of Daphne genkwa.
abstract: The phytochemical investigation of the flower buds of Daphne genkwa yielded eight highly oxygenated daphnane-type diterpene esters, including a new one, genkwanine N 20-palmitate (1) and seven known ones (2-8). The molecular structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, compound 1 showed potential cytotoxic activity in vitro, against A549 and Hep G2 tumour cell lines.
authors: a Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000 , P.R. China.
authors: Hai-Long
authors: HL
authors: Jiang
authors: Rui
authors: R
authors: Wang
authors: Jian-Yong
authors: JY
authors: Li
authors: Yan-Ping
authors: YP
authors: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D032364:Daphne / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification; D035264:Flowers / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010168:Palmitates / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004952:Esters; D010168:Palmitates; C000603289:genkwanine N 20-palmitate
keywords: Daphne genkwa; cytotoxicity; daphnane; diterpenoid