title: Bone regeneration with biomaterials and active molecules delivery.
abstract: The combination of biomaterials and drug delivery strategies is a promising avenue towards improved synthetic bone substitutes. With the delivery of active species biomaterials can be provided with the bioactivity they still lack for improved bone regeneration. Recently, a lot of research efforts have been put towards this direction. Biomaterials for bone regeneration have been supplemented with small or biological molecules for improved osteoprogenitor cell recruitment, osteoinductivity, anabolic or angiogenic response, regulation of bone metabolism and others. The scope of this review is to summarize the most recent results in this field.
authors: AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland. matteo.deste@aofoundation.org.
authors: Matteo
authors: M
authors: D' Este
authors: David
authors: D
authors: Eglin
authors: Mauro
authors: M
authors: Alini
authors: Laura
authors: L
authors: Kyllonen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000378:metabolism; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000008:administration & dosage* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D036341:Intercellular Signaling Peptides and Proteins