title: Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.
abstract: The introduction of silicon in biologically-relevant molecules represents an interesting medicinal chemistry tactic. Its use is mainly confined to the fine-tuning of specific molecular properties and organosilicon compounds are underrepresented in typical screening libraries. As part of the European Lead Factory efforts to generate novel, drug discovery-relevant chemical matter, the design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries is described.
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Raquel
authors: R
authors: Ortega
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Jorge
authors: J
authors: Sanchez-Quesada
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Christoph
authors: C
authors: Lorenz
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Grzegorg
authors: G
authors: Dolega
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Anna
authors: A
authors: Karawajczyk
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Miguel
authors: M
authors: Sanz
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany.
authors: Graham
authors: G
authors: Showell
authors: Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Str. 76a, 44227 Dortmund, Germany. Electronic address: fgiordanetto@tarosdiscovery.com.
authors: Fabrizio
authors: F
authors: Giordanetto
mesh_terms: D015195:Drug Design; D055808:Drug Discovery; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D017646:Organosilicon Compounds; D054852:Small Molecule Libraries
keywords: Bioisostere; Silacycloalkane; Silacyclohexane; Silacyclopentane; Silicon