title: Methylene blue phosphoramidite for DNA labelling.
abstract: We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochemical and optical properties of the resulting MB modified oligonucleotides were confirmed. This new molecule is an important breakthrough in the design of new probes labelled with MB.
authors: Institut des sciences analytiques, CNRS/Université de Lyon. 5, rue de la Doua, 69100 Villeurbanne, France. carole.chaix@isa-lyon.fr.
authors: Gabriel
authors: G
authors: De Crozals
authors: Carole
authors: C
authors: Farre
authors: Monique
authors: M
authors: Sigaud
authors: Philippe
authors: P
authors: Fortgang
authors: Corinne
authors: C
authors: Sanglar
authors: Carole
authors: C
authors: Chaix
mesh_terms: D055664:Electrochemical Techniques; D008751:Methylene Blue / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D008751:Methylene Blue