title: A Predictive Study of the Dynamic Development of the P-Wave Terminal Force in Lead V1 in the Electrocardiogram in Relation to Long-Term Prognosis in Non-ST-Segment Elevation Acute Coronary Syndrome Patients during Hospitalization.
abstract: BACKGROUND
  Changes in the ECG indicator PtfV1 reflect left atrial pressure and left ventricular diastolic function in NSTE-ACS patients during hospitalization. The value of PtfV1 in the evaluation of long-term prognosis in NSTE-ACS is still not clear. The purpose of this study was to investigate the relationship between the dynamic changes in P-wave terminal force in lead V1(PtfV1) in the ECG of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients during hospitalization and the long-term major adverse cardiovascular events (MACEs) of patients.
  
  
  METHODS
  A total of 595 patients who received coronary angiography and were confirmed as NSTE-ACS in the coronary heart disease database of Department of Cardiology of West China Hospital were continuously included. The PtfV1 and other clinical data at admission and discharge were collected and dynamically observed. The end events of follow-up observation were MACEs.
  
  
  RESULTS
  Follow-up was performed on 595 patients for 24.71 ± 1.95 months. There were 127 PtfV1(+) and 468 PtfV1(-) at admission, and the incidences of MACEs were 14.2% and 11.1%, respectively (P = 0.731). Compared with patients with persistent PtfV1(-) ECG at admission and discharge, 53 patients with persistent PtfV1(+) ECG at admission and discharge had increased risk for MACEs (HR: 2.221, 95% CI: 1.072-4.601, P = 0.032); 94 patients with new PtfV1(+) ECG at discharge also had significantly increased risk for MACEs (HR: 2.993, 95% CI: 1.660-5.397, P = 0.000).
  
  
  CONCLUSIONS
  NSTE-ACS patients with persistent PtfV1(+) ECG indicators at admission and discharge and new PtfV1(+) at discharge had significantly increased risk of MACEs.
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Qiao
authors: Q
authors: Li
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Li-Dan
authors: LD
authors: Gu
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Chen
authors: C
authors: Zhang
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Wei
authors: W
authors: Liu
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Yong
authors: Y
authors: Peng
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Hua
authors: H
authors: Chai
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Yuan-Ning
authors: YN
authors: Xu
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Jia-Fu
authors: JF
authors: Wei
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: Mao
authors: M
authors: Chen
authors: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors: De-Jia
authors: DJ
authors: Huang
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies
keywords: P-wave terminal force in lead V1; electrocardiogram; major adverse cardiac events; non-ST-segment elevation acute coronary syndrome