title: Preparation of magnetite-chitosan/methylcellulose nanospheres by entrapment and adsorption techniques for targeting the anti-cancer drug 5-fluorouracil.
abstract: In this work, we have formulated novel nanospheres that could be used in the controlled release of the anticancer drug, 5-fluorouracil (5-FU). The nanospheres are composed of magnetite, containing chitosan (CS) and methylcellulose (MC). The drug entrapment was achieved through the encapsulation and adsorption processes. The effects of the preparation conditions, such as magnetite content, CS/MC ratio, crosslinking concentration, exposure time to glutaraldehyde (GA), and the drug/polymer ratio were investigated for both processes. The 5-FU release was found to follow the Fickian mechanism, and the Langmuir isotherm for the nanospheres was achieved through encapsulation and adsorption processes, respectively.
authors: a Department of Chemistry , Faculty of Science, Gazi University , Teknikokullar, Ankara , Turkey.
authors: Oya
authors: O
authors: Şanlı
authors: a Department of Chemistry , Faculty of Science, Gazi University , Teknikokullar, Ankara , Turkey.
authors: Aslı
authors: A
authors: Kahraman
authors: b Department of Chemistry and Chemical Processing Technology , Technical Sciences Vocational High School, Gazi University , Akyurt, Ankara , Turkey.
authors: Ebru
authors: E
authors: Kondolot Solak
authors: a Department of Chemistry , Faculty of Science, Gazi University , Teknikokullar, Ankara , Turkey.
authors: Merve
authors: M
authors: Olukman
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008747:Methylcellulose / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D009844:Oligosaccharides; C012238:chitotetrose; D008747:Methylcellulose; D005472:Fluorouracil; D052203:Ferrosoferric Oxide
keywords: 5-Fluorouracil; controlled release; drug adsorption; iron oxide; nanoparticles