title: Stimuli-responsive and hemocompatible pseudozwitterionic interfaces.
abstract: We report a novel biomacromolecular formula for the design of hemocompatible gel interfaces of N-isopropylacrylamide (NIPAAm) and mixed-charge pairs of [2-(methacryloyloxy)ethyl]trimethylammonium (TMA) and 3-sulfopropyl methacrylate (SA) with overall electrical neutrality. The study stresses on how well-defined compositions of nonionic NIPAAm and pseudozwitterionic TMA/SA in the poly(NIPAAm-co-TMA/SA) hydrogels along with environmental conditions (temperature, ionic strength, and solution pH) affect swelling and adhesion of biofoulants on their surfaces. When challenged with plasma proteins, bacteria, recalcified platelets, or whole blood, stimuli-responsive hydrogels better resisted their adhesion as the content of mixed charges in the copolymer increased, to reach nonbiofouling for the gels made of 100% TMA/SA. The low hemolytic activity (0.5%) associated with a long plasma clotting time (10 min) suggests excellent hemocompatibility excellent hemocompatibility. Finally, hydrogels containing both NIPAAm and TMA/SA tend to exhibit preferential adhesion of leukocytes.
authors: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University , Jhong-Li, Taoyuan 320, Taiwan.
authors: Antoine
authors: A
authors: Venault
authors: Yong-Sheng
authors: YS
authors: Zheng
authors: Arunachalam
authors: A
authors: Chinnathambi
authors: Sulaiman Ali
authors: SA
authors: Alharbi
authors: Hsin-Tsung
authors: HT
authors: Ho
authors: Yu
authors: Y
authors: Chang
authors: Yung
authors: Y
authors: Chang
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D001422:Bacterial Adhesion / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D057219:Biofouling / Q000517:prevention & control; D001777:Blood Coagulation / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D008689:Methacrylates / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009994:Osmolar Concentration; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D013696:Temperature
chemical_list: C120889:2-(trimethylammonio)ethyl methacrylate; C529206:3-sulfopropyl methacrylate; D000178:Acrylamides; D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; C067295:N-isopropylacrylamide