title: Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging.
abstract: The aim of the present study was to investigate the potential roles of the androgen receptor (AR) and matrix metalloproteinase (MMP)-2 and MMP-9 in hepatocellular carcinoma (HCC) tissues and whether their expression could be used as a predictor of the invasion and stage of cancer. The expression levels of AR, MMP-2 and MMP-9 in HCC tissues and tissues adjacent to the tumor were measured by immunohistochemical staining assay. The expression rates of AR, MMP-2 and MMP-9 in the HCC tissue were 76.67, 73.33 and 76.67%, respectively, all of which were significantly higher than those in the tissues adjacent to the tumor. The expression of these proteins represents the local invasion and stage. AR, MMP-2 and MMP-9 expression levels in HCC tissues have the potential to be employed as predictors of the progression of local cancer invasion and the tumor stage.
authors: Department of Oncology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China.
authors: Yan
authors: Y
authors: Zhang
authors: Department of Oncology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China.
authors: Yucheng
authors: Y
authors: Shen
authors: Department of Pathology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China.
authors: Bin
authors: B
authors: Cao
authors: Department of Oncology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China.
authors: Aiting
authors: A
authors: Yan
authors: Department of Oncology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China.
authors: Haoming
authors: H
authors: Ji
keywords: androgen receptor; hepatocellular carcinoma; matrix metalloproteinase-2; matrix metalloproteinase-9