title: Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus.
abstract: Seven new drimane-type sesquiterpenoids, sulphureuines B-H (1-7), together with four known compounds (8-11), were obtained from cultures of mushroom Laetiporus sulphureus. All of these compounds were tested for their cytotoxicities against five human cancer cell lines (HL-60, SMMC-721, A-549, MCF-7, SW-480), compound 10 showed potent cytotoxic activity against HL-60, SMMC-721, A-549, SW-480, with IC50 values of 37.5, 14.8, 15.6, and 36.1μM, respectively.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; School of Medicine, Kunming University, Kunming 650214, People's Republic of China.
authors: Jiang-Bo
authors: JB
authors: He
authors: School of Medicine, Kunming University, Kunming 650214, People's Republic of China.
authors: Jian
authors: J
authors: Tao
authors: School of Medicine, Kunming University, Kunming 650214, People's Republic of China.
authors: Xi-Song
authors: XS
authors: Miao
authors: Department of Pharmacy, Xijing Hospital, Fouth Military Medical Univrsity, Xi'an 710032, People's Republic of China.
authors: Wei
authors: W
authors: Bu
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors: Shen
authors: S
authors: Zhang
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors: Ze-Jun
authors: ZJ
authors: Dong
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors: Zheng-Hui
authors: ZH
authors: Li
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: fengtao@mail.kib.ac.cn.
authors: Tao
authors: T
authors: Feng
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Instituent of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: jkliu@mail.kib.ac.cn.
authors: Ji-Kai
authors: JK
authors: Liu
mesh_terms: D000363:Agaricales / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D000081223:Polycyclic Sesquiterpenes; D020072:Polyporales / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane
keywords: Drimane-type sesquiterpenoids; Laetiporus sulphureus; Sulphureuines B–H