title: Association between epidermal growth factor receptor mutations and the expression of excision repair cross-complementing protein 1 and ribonucleotide reductase subunit M1 mRNA in patients with non-small cell lung cancer.
abstract: The present study aimed to investigate the association between epidermal growth factor receptor (EGFR) gene mutations and excision repair cross-complementing protein 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) mRNA expression in non-small cell lung cancer (NSCLC) tissue. The quantitative polymerase chain reaction was used to detectEGFRmutations, andERCC1andRRM1mRNA expression in 257 cases of NSCLC. In the NSCLC samples theEGFRmutation rate was 49.03% (126/257). The rate was higher in females and non-smoking patients (P<0.05). High expression ofERCC1mRNA was observed in 47.47% of the samples (122/257), while a highRRM1mRNA expression was observed in 61.87% of the samples (159/257). In comparison with patients with NSCLC withoutEGFRmutations, patients withEGFRmutations had significantly lower levels ofERCC1mRNA expression (P<0.05); however,EGFRmutations and expression levels ofRRM1mRNA were not correlated in NSCLC tissues (P>0.05). In addition,ERCC1mRNA expression was not correlated with the expression levels ofRRM1mRNA (P>0.05). In conclusion, patients with NSCLC withEGFRmutations tend to have a low expression ofERCC1mRNA and may potentially benefit from platinum-based chemotherapy.
authors: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors: Chun-Wei
authors: CW
authors: Xu
authors: Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China.
authors: Gang
authors: G
authors: Wang
authors: Graduate School of Dalian University, Dalian, Liaoning 116622, P.R. China ; The Second Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014030, P.R. China.
authors: Wu-Long
authors: WL
authors: Wang
authors: Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China.
authors: Wen-Bin
authors: WB
authors: Gao
authors: Graduate School of Dalian University, Dalian, Liaoning 116622, P.R. China.
authors: Chuan-Jun
authors: CJ
authors: Han
authors: Department of Clinical Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors: Jing-Shan
authors: JS
authors: Gao
authors: Department of Oncology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors: Yang
authors: Y
authors: Li
authors: Department of Pathology, Shanxi Da Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi 030001, P.R. China.
authors: Lin
authors: L
authors: Wang
authors: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors: Li-Ying
authors: LY
authors: Zhang
authors: Department of Pathology, The People's Hospital of Weifang, Weifang, Shandong 261041, P.R. China.
authors: Yu-Ping
authors: YP
authors: Zhang
authors: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors: Yu-Wang
authors: YW
authors: Tian
authors: Department of Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China.
authors: Jin-Nv
authors: JN
authors: Fang
keywords: epidermal growth factor receptor; excision repair cross-complementing protein 1; individualized treatment; molecular detection; non-small cell lung cancer; ribonucleotide reductase subunit M1