title: Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.
abstract: Metadherin (MTDH), also known as astrocyte-elevated gene-1, was first cloned in 2002 and has been confirmed as an oncogene in numerous types of cancer by previous studies. Overexpression of MTDH has been observed in multiple types of cancer, including breast, esophageal, prostate, cervical and non-small-cell lung cancer, as well as neuroblastoma and hepatocellular carcinoma. However, at present, few investigations into MTDH‑associated prostate cancer have been performed. A previous study suggested that MTDH was expressed at higher levels in prostate cancer samples, compared with those of benign prostatic hyperplasia. The present study aimed to elucidate the effects of MTDH as an oncogene associated with the biological behavior of prostate cancer cells and chemotherapy-sensitivity to cisplatin in vitro. It was demonstrated that the inhibition of MTDH expression promoted cell apoptosis, reduced cell viability and weakened the invasive ability of prostate cancer cells. In addition, the suppression of MTDH expression increased cell sensitivity to cisplatin. Furthermore, it was demonstrated that MTDH‑associated phosphoinositide 3-kinase/Akt signaling pathways may be involved in mediating the biological behavior of prostate cancer.
authors: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors: Yong-Bao
authors: YB
authors: Wei
authors: Department of Urology, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China.
authors: Qiong
authors: Q
authors: Guo
authors: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors: Yun-Liang
authors: YL
authors: Gao
authors: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors: Bin
authors: B
authors: Yan
authors: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors: Zhao
authors: Z
authors: Wang
authors: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors: Jin-Rui
authors: JR
authors: Yang
authors: Department of Respiratory Medicine, The Third Hospital of Changsha, Changsha, Hunan 410015, P.R. China.
authors: Wei
authors: W
authors: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules; D002945:Cisplatin; D008565:Membrane Proteins; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D016601:RNA-Binding Proteins; C483039:MTDH protein, human