title: Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies.
abstract: Most patients (70-90%) with the multiple endocrine neoplasia type 1 (MEN1) syndrome possess germline heterozygous mutations inMEN1that predisposes to tumors of multiple endocrine and nonendocrine tissues. Some endocrine tumors of the kinds seen in MEN1 that occur sporadically in the general population also possess somatic mutations inMEN1. Interestingly, the endocrine tumors of MEN1 are recapitulated in mouse models ofMen1loss that serve as a valuable resource to understand the pathophysiology and molecular basis of tumorigenesis. Exploring these endocrine tumors in mouse models usingin vivo,ex vivoandin vitromethods can help to follow the process of tumorigenesis, and can be useful for preclinical testing of therapeutics and understanding their mechanisms of action.
authors: National Institutes of Health, NIDDK, Metabolic Diseases Branch, Bldg 10, Room 8C-101, Bethesda, MD 20892, USA, Tel.: +1 301 402 7834.
authors: Sunita K
authors: SK
authors: Agarwal
keywords: MEN1; cell cycle; epigenetic; menin; mouse models; tumor suppressor; tumorigenesis