title: Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up.
abstract: Psychiatric manifestations of systemic lupus erythematosus (SLE) that are commonly preceded by organic syndromes include confusional states, anxiety disorder, cognitive dysfunction, mood disorder and psychosis. A 35-year-old woman was admitted to hospital with a relapse of SLE. Laboratory data were exacerbated, with some physical symptoms, and her primary psychiatric symptom was mania. The symptoms were reduced by treatment with prednisolone, methylprednisolone and aripiprazole. Magnetic resonance imaging and single-photon emission computed tomography (SPECT) using (123)I-IMP was then performed and analyzed with three-dimensional stereotactic surface projection. This case emphasizes that SLE can commence with organic syndromes and relapse with predominantly psychiatric symptoms, and that the treatment efficacy may be confirmed using a follow-up of SPECT.
authors: Department of Psychiatry, Saga University, Japan si5059@cc.saga-u.ac.jp amonji@hf.rim.or.jp.
authors: T
authors: T
authors: Hirachi
authors: Department of Psychiatry, Saga University, Japan.
authors: H
authors: H
authors: Ishii
authors: Department of Rheumatology, Saga University, Japan.
authors: Y
authors: Y
authors: Tada
authors: Department of Radiology, Saga University, Japan.
authors: T
authors: T
authors: Noguchi
authors: Department of Psychiatry, Saga University, Japan.
authors: Y
authors: Y
authors: Haraguchi
authors: Department of Psychiatry, Saga University, Japan.
authors: H
authors: H
authors: Tateishi
authors: Department of Psychiatry, Saga University, Japan.
authors: Y
authors: Y
authors: Mizoguchi
authors: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan.
authors: T A
authors: TA
authors: Kato
authors: Department of Psychiatry, Saga University, Japan.
authors: T
authors: T
authors: Kawashima
authors: Department of Psychiatry, Saga University, Japan.
authors: A
authors: A
authors: Monji
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000523:psychology*; D020945:Lupus Vasculitis, Central Nervous System / Q000139:chemically induced; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging / Q000379:methods; D012008:Recurrence; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
keywords: Systemic lupus erythematosus (SLE); magnetic resonance imaging (MRI); mania; relapse; single-photon emission computed tomography (SPECT)