title: Novel atherosclerotic risk factors and angiographic profile of young Gujarati patients with acute coronary syndrome.
abstract: OBJECTIVE
  In this study we aimed to analyse the frequency of atherosclerotic risk factors with focus to novel risk factors for coronary artery disease and angiographic profile in young (≤ 40 years) acute coronary syndrome (ACS) patient with healthy controls in Gujarat, India.
  
  
  METHODS
  Between January 2008 and December 2012, 109 consecutive young patients aged ≤ 40 years old, diagnosed to have ACS were included in the study. All ACS patients underwent diagnostic coronary angiography. An equivalent age and sex matched population without coronary disease with similar risk factors without tobacco considered a control group. All angiographic patients were evaluated for conventional risk factors for coronary artery disease like diabetes mellitus, hypertension, smoking, obesity as well as novel atherogenic risk factors like high sensitivity C-reactive protein (Hs-CRP), Lipoprotein(a) [LP(a)], homocysteine, apolipoprotein A1 (ApoA1) and B (ApoB).
  
  
  RESULTS
  In a study group, out of 109 young patients, 90 (82.6%) patients were presented to our hospital as ST-segment elevation myocardial infarction (STEMI), 10 (9.2%) presented as known non-ST-elevation myocardial infarction (NSTEMI) and 9 (8.3%) presented as unstable angina (UA). Serum cholesterol, triglycerides, LDL, LP(a) and lipid tetrad index were significantly higher in the study group whereas the HDL levels significantly lower as compared to the control group.
  
  
  CONCLUSIONS
  A quite common risk factors of premature CAD are smoking, high Hs-CRP, high LP(a), hyperhomocysteinaemia and positive family history in the young ACS. Most common presentation of ACS in young was STEMI. On angiography, single vessel involvement was the most common finding.
authors: Jayesh
authors: J
authors: Prajapati
authors: Sharad
authors: S
authors: Jain
authors: Kapil
authors: K
authors: Virpariya
authors: Jayesh
authors: J
authors: Rawal
authors: Hasit
authors: H
authors: Joshi
authors: Kamal
authors: K
authors: Sharma
authors: Bhavesh
authors: B
authors: Roy
authors: Ashok
authors: A
authors: Thakkar
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000208:ethnology*; D000328:Adult; D000367:Age Factors; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology*; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000208:ethnology; D012307:Risk Factors