title: Differences in angiotensin (1-7) between men and women.
abstract: In experimental animal models of hypertension, angiotensin (1-7) [ANG-(1-7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. Therefore, this study sought to compare circulating concentrations of ANG-(1-7) in apparently healthy men and women under normal physiological conditions. With the use of a cross-sectional experimental design, blood was collected in EDTA anticoagulant from 42 volunteers (21 men and 21 women; and age range, 19-48 yr) for analysis of plasma concentrations of ANG-(1-7) and ANG II. Blood pressure was measured and vascular endothelial function was determined (n = 25) using the brachial artery flow-mediated dilation (FMD) test. As a result, women exhibited a higher circulating concentration of ANG-(1-7) (P = 0.04) compared with men, whereas values of ANG II were similar between groups. Baseline arterial diameter, peak diameter, and shear rate were significantly greater (P < 0.02) in men compared with women. No significant differences in FMD, FMD normalized for shear, or time to peak dilation were observed between men and women. In addition, a positive correlation between ANG-(1-7) and FMD (P = 0.04) and negative association between ANG-(1-7) with ANG II (P = 0.01) were only identified in men, whereas a positive relationship between ANG-(1-7) and diastolic blood pressure (P = 0.03) was observed in women.
  
  
  CONCLUSIONS
  , women exhibit significantly higher plasma concentrations of ANG-(1-7) compared with men. In addition, this study describes a relationship between ANG-(1-7), vascular function, and diastolic blood pressure that appears to be sex dependent.
authors: Department of Physiology, Georgia Regents University, Augusta, Georgia;
authors: Jennifer C
authors: JC
authors: Sullivan
authors: Division of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, Augusta, Georgia; and.
authors: Paula
authors: P
authors: Rodriguez-Miguelez
authors: Department of Physiology, Georgia Regents University, Augusta, Georgia;
authors: Margaret A
authors: MA
authors: Zimmerman
authors: Division of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, Augusta, Georgia; and Sport and Exercise Science Research Institute, University of Ulster, Jordanstown, Northern Ireland, United Kingdom ryharris@gru.edu.
authors: Ryan A
authors: RA
authors: Harris
mesh_terms: D000328:Adult; D000803:Angiotensin I / Q000097:blood*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001916:Brachial Artery / Q000502:physiology; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D054624:Health Status Disparities; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D012039:Regional Blood Flow; D012737:Sex Factors; D014664:Vasodilation; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: ANG-(1–7), sex; blood pressure; renin-angiotensin system