title: A new chiral C1-symmetric NHC-catalyzed addition to α-aryl substituted α,β-disubstituted enals: enantioselective synthesis of fully functionalized dihydropyranones.
abstract: The first enantioselective NHC-catalyzed activation of α-aryl substituted α,β-disubstituted unsaturated aldehyde is successfully developed via a highly-active acyl azolium intermediate. The new C1-symmetric biaryl-saturated imidazolium exhibits a superior ability to enable previously unavailable transformation, and the corresponding fully functionalized dihydropyranones are efficiently synthesized in high yields with excellent enantioselectivities.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. xupf@lzu.edu.cn.
authors: Hong
authors: H
authors: Lu
authors: Jin-Yu
authors: JY
authors: Liu
authors: Chen-Guang
authors: CG
authors: Li
authors: Jun-Bing
authors: JB
authors: Lin
authors: Yong-Min
authors: YM
authors: Liang
authors: Peng-Fei
authors: PF
authors: Xu