title: [Reproductive problems in women with PCOS, the impact of PAI-1 carriers of 4G PAI-1 polymorphism and BMI].
abstract: Approximately 7-12% of women in reproductive age are affected by PCOS[2] and 40 to 70 percent of them are overweight contributing to the clinical picture of PCOS and increased reproductive and metabolic disorder. In order to investigate the role of PAl-1 as a possible risk factor for the development of PCOS a group of 67 women with polycystic ovarian disease and 70 healthy controls were investigated for levels of PAl-1 and carriage of the promoter polymorphism 675 4G/5G in gene of PAI-1. The correlation with BMI was checked. The results of the DNA analysis showed a high carriage of polymorphism 675 4G/4G in promoter of PAl-1 gene in women with PCOS but not significant (OR = 1.655; p = 0.141), as well in the total group of the patient (OR =1.474; p>0.05). Serum levels of PAI-1 were significantly higher in total group of patients compared to controls. The levels of PAI-1 is correlated with carriage of 675 4G/5G polymorphism in the gene for PAI-1 (r=0.534; p=0.03) as well as with BMI, like correlation coefficients were higherin the group with PCOS (0.572; p=0.04). Data from the disease history showed a higher percentage of women with reproductive problems: early pregnancy loss 48.5% and infertility 23.2%, significantly higher in the group with PCOS (58.1% compared to 32.4%). The carriers of polymorphism 4G are at greater risk for early pregnancy loss than those with 5G (61.45% as compared to 36.8%), which confirms that carriage of the polymorphism 4G/5G 675 gene PAl-1 has a specific in multifactorial pathogenesis and expression of PCOS.
authors: R
authors: R
authors: Komsa-Penkova
authors: G
authors: G
authors: Golemanov
authors: G
authors: G
authors: Georgieva
authors: K
authors: K
authors: Popovski
authors: N
authors: N
authors: Slavov
authors: P
authors: P
authors: Ivanov
authors: K
authors: K
authors: Kovacheva
authors: M
authors: M
authors: Atanasova
authors: A
authors: A
authors: Blajev
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000209:etiology* / Q000235:genetics; D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology* / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D055815:Young Adult
chemical_list: D017395:Plasminogen Activator Inhibitor 1