title: Clickable 5'-γ-ferrocenyl adenosine triphosphate bioconjugates in kinase-catalyzed phosphorylations.
abstract: Clickable co-substrate: A tri-functional 5'-γ-ferrocenyl adenosine triphosphate (Fc-ATP) derivative containing a clickable site was synthesized. This compound is an effective co-substrate in kinase-catalyzed phosphorylation reactions, which can be detected by both electrochemical and immunoassay detection methods. The clickable reaction site makes direct modification possible, which greatly expands its application.
authors: Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4 (Canada); Current address: Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Department of Chemistry, Beijing Institute of Technology, Beijing 100081 (P.R. China).
authors: Nan
authors: N
authors: Wang
authors: Zhe
authors: Z
authors: She
authors: Yen-Chun
authors: YC
authors: Lin
authors: Sanela
authors: S
authors: Martić
authors: David J
authors: DJ
authors: Mann
authors: Heinz-Bernhard
authors: HB
authors: Kraatz
keywords: click chemistry; ferrocenes; peptides; phosphorylation; protein kinases