title: A rapid Fourier-transform infrared (FTIR) spectroscopic method for direct quantification of paracetamol content in solid pharmaceutical formulations.
abstract: A transmission FTIR spectroscopic method was developed for direct, inexpensive and fast quantification of paracetamol content in solid pharmaceutical formulations. In this method paracetamol content is directly analyzed without solvent extraction. KBr pellets were formulated for the acquisition of FTIR spectra in transmission mode. Two chemometric models: simple Beer's law and partial least squares employed over the spectral region of 1800-1000 cm(-1) for quantification of paracetamol content had a regression coefficient of (R(2)) of 0.999. The limits of detection and quantification using FTIR spectroscopy were 0.005 mg g(-(1) and 0.018 mg g(-1), respectively. Study for interference was also done to check effect of the excipients. There was no significant interference from the sample matrix. The results obviously showed the sensitivity of transmission FTIR spectroscopic method for pharmaceutical analysis. This method is green in the sense that it does not require large volumes of hazardous solvents or long run times and avoids prior sample preparation.
authors: National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Pakistan. Electronic address: chemist_ali2007@yahoo.com.
authors: Muhammad Ali
authors: MA
authors: Mallah
authors: National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Pakistan.
authors: Syed Tufail Hussain
authors: ST
authors: Sherazi
authors: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Pakistan.
authors: Muhammad Iqbal
authors: MI
authors: Bhanger
authors: National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Pakistan.
authors: Sarfaraz Ahmed
authors: SA
authors: Mahesar
authors: National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Pakistan.
authors: Muhammad Ashraf
authors: MA
authors: Bajeer
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000737:chemistry; D002138:Calibration; D002626:Chemistry, Pharmaceutical; D016000:Cluster Analysis; D016018:Least-Squares Analysis; D057230:Limit of Detection; D008962:Models, Theoretical; D012015:Reference Standards; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D013607:Tablets; D000082:Acetaminophen
keywords: FTIR spectroscopy; Green method; Paracetamol; Pharmaceutical analysis; Quantitative analysis; Transmission