title: Long-term Outcome of Chondrosarcoma: A Single Institutional Experience.
abstract: OBJECTIVE
  The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors.
  
  
  METHODS
  A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution.
  
  
  RESULTS
  Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage.
  
  
  CONCLUSIONS
  Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome.
authors: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors: Srimanth
authors: S
authors: Bindiganavile
authors: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors: Ilkyu
authors: I
authors: Han
authors: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors: Ji Yeon
authors: JY
authors: Yun
authors: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors: Han-Soo
authors: HS
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000601:surgery*; D002813:Chondrosarcoma / Q000601:surgery*; D003475:Curettage / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: Chondrosarcoma; Histology; Pelvis; Prognosis; Recurrence