title: Survival outcome in endometrial cancer patients according to hereditary predisposition.
abstract: OBJECTIVE
  A familial history of ovarian cancer/breast cancer is considered a significant prognostic factor for ovarian cancer. We investigated hereditary factors by examining the incidence of synchronous malignancy in patients with endometrial cancer, and assessed the prognostic role of heredity in endometrial cancer.
  
  
  METHODS
  We retrospectively evaluated patients with endometrial cancer who underwent surgery from January 2001 to April 2011. A hereditary background in this study was defined as double primary cancer, that is, endometrial cancer accompanied by colon, ovarian, or breast cancer suggestive of Lynch syndrome, hereditary breast ovarian cancer syndrome, or Cowden syndrome, respectively.
  
  
  RESULTS
  Among 282 patients with endometrial cancer in the study population, 20 patients (7.1%) had a hereditary predisposition: 10 patients (3.5%) had ovarian cancer, six patients (2.1%) had breast cancer, and four patients (1.4%) had colon cancer. Age and lower uterine segment involvement were not statistically different between the hereditary and nonhereditary groups. The majority of the women in the hereditary group presented with Stage I cancer; however, there were no significant differences in Stage I cancer between the hereditary group and the sporadic endometrial cancer group (85% and 77%, respectively, p = 0.561). The median follow-up period was 60 months. A 5-year overall survival rate was not different between the two groups (95% and 95%, respectively, p = 0.659). Among a subgroup of patients with Stage I endometrial cancer, the 5-year overall survival rate was lower in the endometrial cancer with a hereditary predisposition group compared with the sporadic endometrial cancer group (94% and 98%, respectively, p = 0.027).
  
  
  CONCLUSIONS
  Seven percent of the women with endometrial cancer in our study had other malignancies such as ovarian, colon, or breast cancer synchronously. Among a subgroup of patients with Stage I cancer in the endometrial cancer with a hereditary predisposition group, the 5-year overall survival rate was significantly lower (94%). This finding should be confirmed in a larger population.
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea; Department of Obstetrics and Gynecology, Chungnam National University Hospital, Daejeon, South Korea.
authors: Heon Jong
authors: HJ
authors: Yoo
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea; Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea. Electronic address: gynlim@gmail.com.
authors: Myong Cheol
authors: MC
authors: Lim
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea; Red Cross College of Nursing, Chung-Ang University, Seoul, South Korea.
authors: Yedong
authors: Y
authors: Son
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea.
authors: Sang-Soo
authors: SS
authors: Seo
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea; Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea.
authors: Sokbom
authors: S
authors: Kang
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea.
authors: Sun Ho
authors: SH
authors: Kim
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea.
authors: Chong Woo
authors: CW
authors: Yoo
authors: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea; Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang-si, South Korea.
authors: Sang-Yoon
authors: SY
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
keywords: endometrial cancer; hereditary predisposition; survival outcome