title: Four-component reaction leading to highly functionalized sulfoalkoxy carbonyl compounds.
abstract: A facile regio- and diastereoselective four-component protocol has been developed involving an α,β-unsaturated carbonyl compound, a cyclic ether, a sulfonic acid and a halogen reagent to access highly anti-α-bromo-β-sulfoalkoxyl carbonyl derivatives. Some of these products have high toxicity against human chronic myeloid leukemia cells.
authors: Division of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian 116023, China. binnawaz@hotmail.com zhaozb@dicp.ac.cn.
authors: Muhammad
authors: M
authors: Sohail
authors: Yixin
authors: Y
authors: Zhang
authors: Guangwei
authors: G
authors: Sun
authors: Xin
authors: X
authors: Guo
authors: Wujun
authors: W
authors: Liu
authors: Chang
authors: C
authors: Liu
authors: Zongbao K
authors: ZK
authors: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001974:Bromosuccinimide / Q000737:chemistry*; D045744:Cell Line, Tumor; D002599:Chalcone / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D002599:Chalcone; D001974:Bromosuccinimide