title: Moderate exercise training attenuates the severity of experimental rodent colitis: the importance of crosstalk between adipose tissue and skeletal muscles.
abstract: Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 10%), and the normal diet (total fat up to 5%) in rats with TNBS colitis forced to treadmill running exercise (5 days/week) for 6 weeks. In nonexercising HFD rats, the area of colonic damage, colonic tissue weight, the plasma IL-1β, TNF-α, TWEAK, and leptin levels, and the expression of IL-1β-, TNF-α-, and Hif1α mRNAs were significantly increased and a significant fall in plasma adiponectin and irisin levels was observed as compared to LFD rats. In HFD animals, the exercise significantly accelerated the healing of colitis, raised the plasma levels of IL-6 and irisin, downregulated the expression of IL-1β, TNF-α, and Hif1α, and significantly decreased the plasma IL-1β, TNF α, TWEAK, and leptin levels. We conclude that HFD delays the healing of colitis in trained rats via decrease in CBF and plasma IL-1β, TNF-α, TWEAK, and leptin levels and the release of protective irisin.
authors: Department of Physical Exercise, Faculty of Health Care, Jagiellonian University Medical College, 20 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Jan
authors: 0000-0002-2699-3798
authors: J
authors: Bilski
authors: Department of Physical Exercise, Faculty of Health Care, Jagiellonian University Medical College, 20 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Agnieszka I
authors: AI
authors: Mazur-Bialy
authors: Gastroenterology and Hepatology Clinic, Jagiellonian University Medical College, 5 Sniadeckich Street, 31-501 Cracow, Poland.
authors: Bartosz
authors: 0000-0003-4207-9231
authors: B
authors: Brzozowski
authors: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Marcin
authors: 0000-0003-0175-5600
authors: M
authors: Magierowski
authors: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Katarzyna
authors: 0000-0002-4866-1102
authors: K
authors: Jasnos
authors: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Gracjana
authors: G
authors: Krzysiek-Maczka
authors: Department of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Katarzyna
authors: K
authors: Urbanczyk
authors: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Agata
authors: A
authors: Ptak-Belowska
authors: Gastroenterology and Hepatology Clinic, Jagiellonian University Medical College, 5 Sniadeckich Street, 31-501 Cracow, Poland.
authors: Malgorzata
authors: 0000-0003-4171-2103
authors: M
authors: Zwolinska-Wcislo
authors: Gastroenterology and Hepatology Clinic, Jagiellonian University Medical College, 5 Sniadeckich Street, 31-501 Cracow, Poland.
authors: Tomasz
authors: T
authors: Mach
authors: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland.
authors: Tomasz
authors: T
authors: Brzozowski
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000097:blood; D003092:Colitis / Q000097:blood* / Q000378:metabolism*; D000074049:Cytokine TWEAK; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D053583:Interleukin-1beta / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D048069:Tumor Necrosis Factors / Q000097:blood
chemical_list: D051017:Apoptosis Regulatory Proteins; D000074049:Cytokine TWEAK; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D053583:Interleukin-1beta; D020738:Leptin; D008565:Membrane Proteins; C497771:Tnfsf12 protein, rat; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors