title: Spicing up the sensation of stretch: TRPV1 controls mechanosensitive Piezo channels.
abstract: Piezo proteins--a family of mammalian cation-selective ion channels that respond to mechanical stretch--are molecular mediators of biological processes, including vascular tone, hearing, touch, and pain. In this issue of Science Signaling, Rohacs and colleagues demonstrate that activation of the heat-sensitive transient receptor potential vanilloid 1 (TRPV1), another cation channel, inhibits Piezo channels through a calcium-induced depletion of phosphoinositides. This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.
authors: Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases. Inflammation Research Network, University of Calgary, Calgary, Alberta T2N 4N1, Canada. altier@ucalgary.ca.
authors: Christophe
authors: C
authors: Altier
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000166:cytology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D010716:Phosphatidylinositols; D050916:TRPV Cation Channels; D002211:Capsaicin