title: Tridentate hydrazone metal complexes derived from cephalexin and 2-hydrazinopyridine: synthesis, characterization and antibacterial activity.
abstract: Metal(II) coordination compounds of a tridentate hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2-hydrazinopyridine were synthesized. The hydrazone ligand and mononuclear [ML(OAc)(H2O)] (M(II)=Mn, Co, Ni, Cu, Zn, Ag) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and (1)H NMR spectral studies. The cephalexin 2-pyridinylhydrazone ligand HL behaves as a monoanionic tridentate NNO chelating agent. The biological applications of complexes have been studied on three bacteria strains (Escherichia coli, Acinetobacter baumannii and Enterococcus faecalis) by agar diffusion disc method.
authors: Department of Chemistry, Universidad de Oriente, Cumana 6101 Venezuela. Electronic address: juananacona@hotmail.com.
authors: J R
authors: JR
authors: Anacona
authors: Department of Chemistry, Universidad de Oriente, Cumana 6101 Venezuela.
authors: Maria
authors: M
authors: Rincones
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002506:Cephalexin / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006835:Hydrazones / Q000737:chemistry*; D060328:Magnetic Phenomena; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D011728:Pyridones / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014732:Vibration
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D006835:Hydrazones; D008670:Metals; D011728:Pyridones; C062607:2-hydrazinopyridine; D002506:Cephalexin
keywords: Antibacterial activity; Cephalexin 2-pyridinylhydrazone ligand; Hydrazone metal complexes; Magnetic and spectral studies; Synthesis hydrazone containing cephalexin