title: Transmitted drug resistance in recently infected HIV-positive Individuals from four urban locations across Asia (2007-2010) - TASER-S.
abstract: BACKGROUND
  The availability of HIV antiretroviral therapy (ART) has been associated with the development of transmitted drug resistance-associated mutations (TDRM). TDRM can compromise treatment effectiveness in patients initiating ART and the prevalence can vary in different clinical settings. In this study, we investigated the proportion of TDRM in treatment-naïve, recently infected HIV-positive individuals sampled from four urban locations across Asia between 2007-2010.
  
  
  METHODS
  Patients enrolled in the TREAT Asia Studies to Evaluate Resistance - Surveillance Study (TASER-S) were genotyped prior to ART initiation, with resulting resistance mutations analysed according to the WHO 2009 list.
  
  
  RESULTS
  Proportions of TDRM from recently infected individuals from TASER-S ranged from 0% to 8.7% - Hong Kong: 3/88 (3.4%, 95% CI (0.71%-9.64%)); Thailand: Bangkok: 13/277 (4.7%, 95% CI (2.5%-7.9%)), Chiang Mai: 0/17 (0%, 97.5% CI (0%-19.5%)); and the Philippines: 6/69 (8.7%, 95% CI (3.3%-18.0%)). There was no significant increase in TDRM over time across all four clinical settings.
  
  
  CONCLUSIONS
  The observed proportion of TDRM in TASER-S patients from Hong Kong, Thailand and the Philippines was low to moderate during the study period. Regular monitoring of TDRM should be encouraged, especially with the scale-up of ART at higher CD4 levels.
authors: The Kirby Institute, UNSW Australia, Sydney, Australia.
authors: Awachana
authors: A
authors: Jiamsakul
authors: Faculty of Medicine, Chulalongkorn University and HIV-NAT/The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
authors: Sunee
authors: S
authors: Sirivichayakul
authors: Research Institute for Tropical Medicine, Manila, Philippines.
authors: Rossana
authors: R
authors: Ditangco
authors: Integrated Treatment Centre, Hong Kong, China.
authors: Ka-Hing
authors: KH
authors: Wong
authors: Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China.
authors: Patrick Ck
authors: PC
authors: Li
authors: Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors: Jutarat
authors: J
authors: Praparattanapan
authors: Faculty of Medicine, Chulalongkorn University and HIV-NAT/The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
authors: Praphan
authors: P
authors: Phanuphak
authors: Research Institute for Tropical Medicine, Manila, Philippines.
authors: Edelwisa
authors: E
authors: Segubre-Mercado
authors: Department of Microbiology, Queen Mary Hospital, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
authors: Wing-Cheong
authors: WC
authors: Yam
authors: Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors: Thira
authors: T
authors: Sirisanthana
authors: TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
authors: Thida
authors: T
authors: Singtoroj
authors: The Kirby Institute, UNSW Australia, Sydney, Australia.
authors: Matthew
authors: M
authors: Law
keywords: Asia; Drug resistance; Recent-infection; Resource-limited; Transmitted