title: Composite Hemangioendothelioma of the Submandibular Region.
abstract: Composite hemangioendothelioma (HE) is a rare vascular neoplasm of intermediate malignant potential that predominantly occurs within the dermis or subcutis of the extremities, and occurs in a wide age range. It is locally aggressive with a high rate of local recurrence, and more rarely regional lymph node or distant metastasis. Histologically, it is composed of a complex admixture of benign, intermediate and malignant vascular components. Although composite HE may contain angiosarcoma-like areas, its prognosis is better than that of pure angiosarcoma. We describe a case of composite HE presenting as a submandibular mass in a 43 year-old male, which included areas of prominent 'high grade' epithelioid angiosarcoma. This adds to the range of anatomic sites of these neoplasms, highlights the importance of recognition of the head and neck as a potential site, and emphasizes the importance of accurate diagnosis for correct management (including of long term follow up) and prognostication.
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, SW3 6JJ, UK.
authors: Sarah Lam Shang
authors: SL
authors: Leen
authors: Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK.
authors: Peter M
authors: PM
authors: Clarke
authors: Department of Histopathology, Ipswich Hospital, Ipswich, UK.
authors: John
authors: J
authors: Chapman
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, SW3 6JJ, UK.|Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK.
authors: Cyril
authors: C
authors: Fisher
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, SW3 6JJ, UK. khin.thway@rmh.nhs.uk.|Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK. khin.thway@rmh.nhs.uk.
authors: Khin
authors: K
authors: Thway
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D006390:Hemangioendothelioma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013365:Submandibular Gland Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Composite hemangioendothelioma; Head and neck; Soft tissue tumor