title: Increasing carbapenem-resistant Gram-negative bacilli and decreasing metallo-β-lactamase producers over eight years from Korea.
abstract: The trends and types of carbapenemase-producing Gram-negative bacilli were analyzed from clinical specimens collected between 2005 and 2012 at a Korean teaching hospital. The proportions of carbapenem-resistant Acinetobacter spp. increased markedly to 66%. Metallo-β-lactamase producers significantly decreased and the majority shifted from the bla(VIM-2) type to the bla(IMP-1) type.
authors: Department of Laboratory Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors: Yangsoon
authors: Y
authors: Lee
authors: Korean Institute of Tuberculosis, Osong, Korea.
authors: Chang-Ki
authors: CK
authors: Kim
authors: Department of Laboratory Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
authors: Hae-Sun
authors: HS
authors: Chung
authors: Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. deyong@yuhs.ac.
authors: Dongeun
authors: D
authors: Yong
authors: Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Seok Hoon
authors: SH
authors: Jeong
authors: Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Kyungwon
authors: K
authors: Lee
authors: Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Yunsop
authors: Y
authors: Chong
mesh_terms: D000150:Acinetobacter / Q000145:classification / Q000187:drug effects / Q000201:enzymology*; D000151:Acinetobacter Infections / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins; D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008826:Microbial Sensitivity Tests / Q000639:trends; D011159:Population Surveillance; D011549:Pseudomonas / Q000145:classification / Q000187:drug effects / Q000201:enzymology; D056910:Republic of Korea / Q000453:epidemiology; D001618:beta-Lactamases / Q000096:biosynthesis / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Gram-negative bacilli; carbapenem; metallo-β-lactamase