title: [Repeated inflammatory pain syndrome in newborn male rats changes adaptive behavior during adolescent period of development].
abstract: The study is devoted to the investigation of the effects of the repeated inflammatory pain syndrome of newborn male rat pups at the age of one and two days of life on characteristics of adaptive behaviors in the formalin test, the elevated-plus maze, the forced swim test and also in the swimming pool spatial test in these animals at the age of 25 days. The new data are enhancement of functional activity of the tonic nociceptive system, an increase in depression like behavior, impairment of spatial learning. A priority fact has been obtained that indicates that a short (60 min) repeated maternal deprivation of newborn rat pups (a stressful impact) without inflammatory noxious impact results in changes of the adaptive behaviors in 25-day-old animals. The evaluation of pain patterns organized at different levels of the central nervous system in the formalin test let us to find differences between effects of early painful and stressful impacts on the behavioral indices under study.
authors: I P
authors: IP
authors: Butkevich
authors: V A
authors: VA
authors: Mikhaĭlenko
authors: Iu A
authors: IuA
authors: Lavrova
authors: N A
authors: NA
authors: Ulanova
mesh_terms: D000223:Adaptation, Psychological; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D003863:Depression / Q000503:physiopathology / Q000523:psychology*; D007249:Inflammation / Q000503:physiopathology / Q000523:psychology; D008297:Male; D018782:Maze Learning; D010146:Pain / Q000503:physiopathology / Q000523:psychology*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception; D013550:Swimming