title: The patterns of fractional amplitude of low-frequency fluctuations in depression patients: the dissociation between temporal regions and fronto-parietal regions.
abstract: OBJECTIVE
  This study surveyed the characteristics of the indicator for the fluctuations of default brain activity, fractional amplitude of low-frequency fluctuations (fALFF), in patients with pure major depressive disorder (MDD).
  
  
  METHODS
  Forty-four patients with MDD and 27 normal controls were enrolled in our study. All the participants received the resting-state functional magnetic resonance imaging (rs-fMRI) scans, which were pre-processed by the REST toolbox (resting-state functional MRI data analysis toolbox). The group-related differences of the fALFF between patients and controls were explored by performing comparisons of the fALFF values obtained from rs-fMRI data. The fALFF outputs of patients and controls were compared with global brain volume, age and gender as covariates. In addition, the correlations between the clinical variables (such as depression severity, anxiety severity, illness duration) and fALFF values were also estimated in each group and across both groups.
  
  
  RESULTS
  The patients with MDD had significantly higher fALFF values than the controls, for the left temporal subgyral region. In the contrary, the patients had lower values of fALFF than controls, for the right frontal subcallosal gyrus and right parietal postcentral gyrus. In addition, the fALFF values were negatively correlated with the depression severity in the left temporal subgyral region.
  
  
  CONCLUSIONS
  MDD patients had dissociable alterations in the fALFF values of the fronto-parietal and temporal regions. The pattern of fALFF alterations might be unique for depression patients with later onset-age of young adult phase.
authors: Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
authors: Chien-Han
authors: CH
authors: Lai
authors: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC; Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: ytwu@ym.edu.tw.
authors: Yu-Te
authors: YT
authors: Wu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology*; D055815:Young Adult
keywords: Depression; Postcentral gyrus; Subcallosal gyrus; Temporal subgyral; fALFF