title: FN1: a novel fusion partner of ALK in an inflammatory myofibroblastic tumor.
abstract: Inflammatory myofibroblastic tumors (IMTs) are rare tumors characterized as low-to-intermediate grade sarcomas. Rearrangements of the anaplastic lymphoma kinase (ALK) gene have been reported in IMT. Here, we describe a novel fusion gene in an IMT tumor specimen. A 12-year-old male was admitted to our hospital with a bladder tumor. We identified the fibronectin 1 gene (FN1) as a fusion partner of ALK using 5'RACE. This novel fusion, FN1-ALK, resulted in ALK overexpression in the IMT. This finding should clarify the causes of IMT and facilitate development of novel therapeutics.
authors: Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Kazutaka
authors: K
authors: Ouchi
authors: Mitsuru
authors: M
authors: Miyachi
authors: Yusuke
authors: Y
authors: Tsuma
authors: Kunihiko
authors: K
authors: Tsuchiya
authors: Tomoko
authors: T
authors: Iehara
authors: Eiichi
authors: E
authors: Konishi
authors: Akio
authors: A
authors: Yanagisawa
authors: Hajime
authors: H
authors: Hosoi
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002648:Child; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism*; D006104:Granuloma, Plasma Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D058628:Myofibroblasts / Q000473:pathology*; D009379:Neoplasms, Muscle Tissue / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015514:Oncogene Proteins, Fusion; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C067625:FN1 protein, human; D005353:Fibronectins; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: ALK gene fusion; FN1; inflammatory myofibroblastic tumor