title: Collective cell migration induced by mechanical stress and substrate adhesiveness.
abstract: Mechanical stress normal to the boundary of a tissue sheet can arise in both constrained as well as unconstrained epithelial layers through pushing and pulling of surrounding tissue and substrate adhesiveness, respectively. A continuum model is used to investigate how such stress influences the epithelial dynamics. Four types of spreading and motility can be identified: a uniformly stretched stationary state, uniform sheet migration, active stress compensation by polarization close to the boundary, and a wormlike progression by deformation waves. Analytical and numerical solutions are presented along with bifurcation diagrams using normal stress and active force as control parameters.
authors: Département de Physique, École Normale Supérieure, 24 rue Lhomond, 75005 Paris, France.
authors: Michael H
authors: MH
authors: Köpf
mesh_terms: D000268:Adhesiveness; D002465:Cell Movement; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000166:cytology*; D008954:Models, Biological; D013314:Stress, Mechanical