title: Prognostic significance of programmed cell death 1 (PD-1) or PD-1 ligand 1 (PD-L1) Expression in epithelial-originated cancer: a meta-analysis.
abstract: The expression of programmed cell death 1 (PD-1) and its ligand (PD-L1) has been observed in various epithelial-originated malignancies. However, whether the expression of PD-L1 on tumor cells or the expression of PD-1 on tumor-infiltrating lymphocytes (TILs) is associated with patients' survival remains controversial.Electronic databases were searched for eligible literatures. Data of hazard ratio (HR) for overall survival (OS) with 95% confidence interval (CI) according to the expression status of PD-L1 or PD-1 evaluated by immunohistochemistry were extracted. The outcomes were synthesized based on random-effects model. Subgroup analyses were proposed.Twenty-nine studies covering 12 types of epithelial-originated malignancies involving 7319 patients (2030/3641 cases for PD-L1 positive/negative, 505/1143 cases for PD-1 positive/negative) with available data of the outcome stratified by PD-L1/PD-1 status were enrolled. Epithelial-originated cancer patients with positive expression of PD-L1 on tumor tissues were associated with significantly poorer OS when compared to those with negative expression of PD-L1 (HR 1.81, 95% CI 1.33-2.46, P < 0.001). Similarly, patients with PD-1 positive expression on TILs had significantly shorter OS than the PD-1 negative group (HR 2.53, 95% CI 1.22-5.21, P = 0.012). In analyses of PD-L1, all subgroups showed consistent trends toward unfavorable prognoses of patients with positive PD-L1 expression, regardless of antibodies and evaluation cutoffs. Subgroup analyses on PD-1 were not available due to limited data.PD-L1 or PD-1 expression status is a significant prognostic factor in epithelial-originated malignancies.
authors: From the Department of Thoracic Surgery (YZ, SK, JS, JH, LJ, WW, ZG, GP, GC, JH, WL), the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease (YZ, SK, JS, JH, LJ, WW, ZG, GP, GC, JH, WL); and Zhongshan School of Medicine (YZ, SK, GC), Sun Yat-sen University, Guangzhou, China.
authors: Yaxiong
authors: Y
authors: Zhang
authors: Shiyang
authors: S
authors: Kang
authors: Jianfei
authors: J
authors: Shen
authors: Jiaxi
authors: J
authors: He
authors: Long
authors: L
authors: Jiang
authors: Wei
authors: W
authors: Wang
authors: Zhihua
authors: Z
authors: Guo
authors: Guilin
authors: G
authors: Peng
authors: Gang
authors: G
authors: Chen
authors: Jianxing
authors: J
authors: He
authors: Wenhua
authors: W
authors: Liang
mesh_terms: D060890:B7-H1 Antigen / Q000032:analysis*; D004848:Epithelium; D006801:Humans; D009369:Neoplasms / Q000737:chemistry* / Q000473:pathology*; D011379:Prognosis; D061026:Programmed Cell Death 1 Receptor / Q000032:analysis*
chemical_list: D060890:B7-H1 Antigen; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor