title: Premature ovarian failure: clinical presentation and treatment.
abstract: Premature ovarian failure is a devastating diagnosis for reproductive-aged women. The diagnosis is relatively easy. However, it has serious health consequences, including psychological distress, infertility, osteoporosis, autoimmune disorders, ischemic heart disease, and increased risk for mortality. Management should be initiated immediately to prevent long-term consequences. Estrogen therapy is the mainstay of management. Postmenopausal estrogen therapy studies should not be used to determine the risks of treatment in these young women.
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite E350, Houston, TX 77030, USA. Electronic address: ekovanci@bcm.edu.
authors: Ertug
authors: E
authors: Kovanci
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite E350, Houston, TX 77030, USA.
authors: Amy K
authors: AK
authors: Schutt
mesh_terms: D004967:Estrogens / Q000172:deficiency / Q000627:therapeutic use*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D018587:Oocyte Donation; D010024:Osteoporosis; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis
chemical_list: D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone
keywords: Autoimmune disorders; Estrogen therapy; Heart disease; Infertility; Osteoporosis; Ovarian failure