title: Pharmacokinetic considerations for drugs administered in the critically ill.
abstract: Significant physiological changes are common among critically ill patients. This case-based review describes the consequences of these changes on the selection and dosing of medications.
authors: Resident in the Department of General Surgery and Department of Critical Care Medicine, Dalhousie University, Halifax NS, Canada B3H 3A7.
authors: Gavin
authors: G
authors: Tansley
authors: Richard
authors: R
authors: Hall
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000925:Anticoagulants / Q000493:pharmacokinetics / Q000627:therapeutic use; D016638:Critical Illness; D004347:Drug Interactions; D018495:Fluid Shifts; D005440:Fluid Therapy; D006495:Heparin, Low-Molecular-Weight / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D054556:Venous Thromboembolism / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D012709:Serum Albumin