title: Association between pulse wave velocity and a marker of renal tubular damage (N-acetyl-β-D-glucosaminidase) in patients without diabetes.
abstract: The authors assessed the association between the ratio of urinary activity of N-acetyl-β-D-glucosaminidase (NAG) to creatinine and the brachial-ankle pulse wave velocity (baPWV) in patients without overt diabetes mellitus (DM). This was a cross-sectional study of 233 patients who had an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m(2) and no history of kidney disease. Patients were divided into two groups: high NAG group (>5.8 U/g creatinine) and low NAG group (≤5.8 U/g creatinine). Mean baPWVs of the high NAG group were significantly higher than those of the low NAG group in both the eGFR ≥30 and <60 tertiles and the eGFR ≥60 and <90 tertiles. The baPWV was positively correlated with NAG in all patients (r=0.341, P<.001). Stepwise multivariate regression analysis showed that the baPWV was significantly related with NAG, age, and systolic blood pressure. Elevated NAG is related to elevated arterial stiffness in patients without DM.
authors: Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
authors: Motoshi
authors: M
authors: Ouchi
authors: Kenzo
authors: K
authors: Oba
authors: Taro
authors: T
authors: Saigusa
authors: Kentaro
authors: K
authors: Watanabe
authors: Makoto
authors: M
authors: Ohara
authors: Noriaki
authors: N
authors: Matsumura
authors: Tatsuya
authors: T
authors: Suzuki
authors: Naohiko
authors: N
authors: Anzai
authors: Shuichi
authors: S
authors: Tsuruoka
authors: Masahiro
authors: M
authors: Yasutake
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers; D001783:Blood Flow Velocity / Q000502:physiology*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015415:Biomarkers; D003404:Creatinine; D000118:Acetylglucosaminidase