title: 14-3-3ζ turns TGF-β to the dark side.
abstract: TGF-β/SMAD signaling has long been known to exhibit a dual role in cancer, questioning what determines its context-dependent functions. In this issue of Cancer Cell, Xu and colleagues describe a critical role of the adaptor protein 14-3-3ζ in modulating SMAD activities by changing its interaction partners during breast cancer progression.
authors: Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, the Netherlands; Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 75124 Uppsala, Sweden. Electronic address: p.ten_dijke@lumc.nl.
authors: Peter
authors: P
authors: ten Dijke
authors: Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, the Netherlands; Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 75124 Uppsala, Sweden.
authors: Hans
authors: H
authors: van Dam
mesh_terms: D048948:14-3-3 Proteins / Q000235:genetics*; D001859:Bone Neoplasms / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D000075746:Zinc Finger Protein Gli2
chemical_list: D048948:14-3-3 Proteins; C082593:GLI2 protein, human; D051741:Kruppel-Like Transcription Factors; D009687:Nuclear Proteins; C495901:TP53 protein, human; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53; C572235:YWHAZ protein, human; D000075746:Zinc Finger Protein Gli2