title: Dynamic mechanical assessment of muscle hyperalgesia in humans: the dynamic algometer.
abstract: BACKGROUND
  Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed.
  
  
  OBJECTIVE
  To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry.
  
  
  METHODS
  The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry. The device consisted of a wheel that was rolled over the muscle tissue with a fixed velocity and different predefined forces. The pain threshold force was determined and pain intensity to a fixed-force stimulation was continuously rated on a visual analogue scale while the wheel was rolling over the muscle. The pressure pain sensitivity was evaluated before, during, and after muscle pain and hyperalgesia induced unilaterally by either injection of hypertonic saline (0.5 mL, 6%) into the tibialis anterior or eccentric exercise evoking delayed-onset muscle soreness (DOMS).
  
  
  RESULTS
  The intraclass correlation coefficient was >0.88 for the dynamic thresholds; thus, the method was reliable. Compared with baseline, both techniques detected hyperalgesia at the saline injection site and during DOMS (P<0.05). The dynamic algometer also detected the widespread, patchy distribution of sensitive loci during DOMS, which was difficult to evaluate using static pressure algometry.
  
  
  CONCLUSIONS
  The present study showed that dynamic pressure algometry is a reliable tool for evaluating muscle hyperalgesia (threshold and pain rating) with high temporal and spatial resolution. It can be applied as a simple clinical bed-side test and as a quantitative tool in pharmacological profiling studies.
authors: Sara
authors: S
authors: Finocchietti
authors: Thomas
authors: T
authors: Graven-Nielsen
authors: Lars
authors: L
authors: Arendt-Nielsen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000175:diagnosis*; D008297:Male; D018482:Muscle, Skeletal; D010147:Pain Measurement / Q000295:instrumentation*; D017288:Pain Threshold; D014110:Touch; D055815:Young Adult