title: Evolution and diversification of the basal transcription machinery.
abstract: Transcription initiation was once thought to be regulated primarily by sequence-specific transcription factors with the basal transcription machinery being largely invariant. Gradually it became apparent that the basal transcription machinery greatly diversified during evolution and new studies now demonstrate that diversification of the TATA-binding protein (TBP) family yielded specialized and largely independent transcription systems.
authors: Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: sduttke@ucsd.edu.
authors: Sascha H C
authors: SH
authors: Duttke
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors
keywords: TATA-binding protein (TBP); TBP-related factor (TRF); basal transcription machinery; diversification; evolution; gene regulation; system factors; transcription