title: Lack of association between using aspirin and development of non-Hodgkins lymphoma: a meta-analysis.
abstract: BACKGROUND
  Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis.
  
  
  METHODS
  A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and I2 statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis.
  
  
  RESULTS
  Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively.
  
  
  CONCLUSIONS
  In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.
authors: Neda
authors: N
authors: Amoori
authors: Social Determinants of Heath Research Center, School of Public Heath, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran E-mail : Epidemiology2012@gmail.com.
authors: Maria
authors: M
authors: Cheraghi
authors: Hosein
authors: H
authors: Fallahzadeh
authors: Hossein
authors: H
authors: Rahmani
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000453:epidemiology*; D008297:Male; D018570:Risk Assessment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin