title: [The estimation of age-related sensitivity of the retinal pigment epithelium of Japanese quail (Coturnix japonica) to the light damage].
abstract: The effect of blue light damage (445-455 nm, 4 J/cm2) to retinal pigment epithelium (RPE) subcellular structures was investigated in 4 age risk groups (9, 25, 40 and 52 weeks) of Japanese quail Coturnix japonica by light and electron microscopy. The indicator of biological aging of RPE was age-related accumulation of lipofuscin granules: 5-6-fold increase in their quantity increasing by 5-6 times in quails at 52 weeks. The main photo-induced changes observed after 24 h of the photo radiation were located in the blood-retinal barrier, such as loss of homogeneity of Bruch's membrane, disorganization of basal processes, deformations of the nuclei and mitochondria shapes. Those effects ofphotobleaching were more expressed in young birds. But for the older 52-week age birds it was not so noticeable, because their retinal pigment epithelium structures had disorders which were similar to those in younger birds after photodamage.
authors: P P
authors: PP
authors: Zak
authors: N B
authors: NB
authors: Serezhnikova
authors: L S
authors: LS
authors: Pogodina
authors: N N
authors: NN
authors: Trofimova
authors: M A
authors: MA
authors: Ostrovskiĭ
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001813:Blood-Retinal Barrier / Q000528:radiation effects* / Q000648:ultrastructure; D016570:Bruch Membrane / Q000528:radiation effects* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000528:radiation effects / Q000648:ultrastructure; D003370:Coturnix; D003594:Cytoplasmic Granules / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D005260:Female; D008027:Light; D008062:Lipofuscin / Q000378:metabolism; D017348:Microscopy, Electron, Scanning Transmission; D008928:Mitochondria / Q000528:radiation effects / Q000648:ultrastructure; D055213:Retinal Pigment Epithelium / Q000528:radiation effects* / Q000648:ultrastructure
chemical_list: D008062:Lipofuscin