title: Polycystic kidney disease in four British shorthair cats with successful treatment of bacterial cyst infection.
abstract: Polycystic kidney disease is the most common inherited disorder in cats. Renal cysts progressively increase in size and number, resulting in a gradual decrease in kidney function. An autosomal dominant mutation in exon 29 of the polycystin-1 gene has been identified, mostly in Persian and Persian-related breeds. This case study describes polycystic kidney disease in four British shorthair cats, of which two had the same genetic mutation reported in Persian and Persian-related cats. This likely reflects introduction of this mutation into the British shorthair breeding line because of previous outcrossing with Persian cats. An infected renal cyst was diagnosed and successfully treated in one of the cats. This is a commonly reported complication in human polycystic kidney disease, and to the authors' knowledge has not previously been reported in cats with polycystic kidney disease.
authors: Department of Small Animal Internal Medicine, Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, the Hebrew University of Jerusalem, Rehovot, 761001, Israel.
authors: R
authors: R
authors: Nivy
authors: Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri - Columbia, Columbia, MO, 65211, USA.
authors: L A
authors: LA
authors: Lyons
authors: Department of Small Animal Internal Medicine, Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, the Hebrew University of Jerusalem, Rehovot, 761001, Israel.
authors: I
authors: I
authors: Aroch
authors: Department of Small Animal Internal Medicine, Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, the Hebrew University of Jerusalem, Rehovot, 761001, Israel.
authors: G
authors: G
authors: Segev
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001947:Breeding; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D002415:Cats; D003937:Diagnosis, Differential; D004739:England; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D005260:Female; D008297:Male; D007690:Polycystic Kidney Diseases / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D016482:Urinalysis / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents