title: Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate.
abstract: OBJECTIVE
  To compare dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate (MTA) in dogs.
  
  
  METHODS
  Pulps in 36 incisors of three 8-month-old beagle dogs were mechanically exposed and assigned to two experimental groups (iRoot BP Plus group and MTA group, n = 15 per group) and one control group (n = 6). Direct pulp capping was performed using either iRoot BP Plus or MTA. The animals were sacrificed 3 months later. Histological sections were stained with haematoxylin and eosin and categorized using a histologic scoring system. Statistical analysis was performed using the Mann-Whitney U-test, with the significance set at 0.05.
  
  
  RESULTS
  The majority of specimens in both experimental groups were associated with complete calcified bridge formation and the absence of pulpal inflammation. There was no significant difference in pulp response to iRoot BP Plus or MTA after 3 months (P > 0.05).
  
  
  CONCLUSIONS
  iRoot BP Plus and MTA had similar favourable results when used as pulp-capping agents.
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.
authors: S
authors: S
authors: Shi
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.|Key Laboratory of Oral Disease of Liaoning Province, China Medical University, Shenyang, China.
authors: Z F
authors: ZF
authors: Bao
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.|Key Laboratory of Oral Disease of Liaoning Province, China Medical University, Shenyang, China.
authors: Y
authors: Y
authors: Liu
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.
authors: D D
authors: DD
authors: Zhang
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.|Key Laboratory of Oral Disease of Liaoning Province, China Medical University, Shenyang, China.
authors: X
authors: X
authors: Chen
authors: Department of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.|Key Laboratory of Oral Disease of Liaoning Province, China Medical University, Shenyang, China.
authors: L M
authors: LM
authors: Jiang
authors: Department of Oral Pathology, School of Stomatology, China Medical University, Shenyang, China.
authors: M
authors: M
authors: Zhong
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D017610:Calcium Compounds / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods*; D004285:Dogs; D004338:Drug Combinations; D010087:Oxides / Q000494:pharmacology*; D057872:Pulp Capping and Pulpectomy Agents / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D017640:Silicates; C000600177:iRoot BP Plus; C086631:mineral trioxide aggregate
keywords: iRoot BP Plus; mineral trioxide aggregate; pulp capping