title: Monodispersed nanoparticles of conjugated polyelectrolyte brush with high charge density for rapid, specific and label-free detection of tumor marker.
abstract: Highly charged nanoparticles of a conjugated polyelectrolyte brush were used to sense the human α-fetoprotein (AFP) by observing selective superquenching in several minutes. The unique property of nanoparticles that the self-aggregation causes an unchanged or enhanced fluorescence can reduce the interference from non-target substance significantly.
authors: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China. iamqlfan@njupt.edu.cn iamwhuang@njtech.edu.cn.
authors: Xingfen
authors: X
authors: Liu
authors: Lin
authors: L
authors: Shi
authors: Zhiyong
authors: Z
authors: Zhang
authors: Quli
authors: Q
authors: Fan
authors: Yanqin
authors: Y
authors: Huang
authors: Shao
authors: S
authors: Su
authors: Chunhai
authors: C
authors: Fan
authors: Lianhui
authors: L
authors: Wang
authors: Wei
authors: W
authors: Huang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000097:blood; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000191:economics / Q000379:methods*; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: C097353:AFP protein, human; D014408:Biomarkers, Tumor; D004573:Electrolytes; D011108:Polymers; D000509:alpha-Fetoproteins