title: Pd(II)-catalyzed, controllable C-H mono-/diarylation of aryl tetrazoles: concise synthesis of Losartan.
abstract: A palladium(II)-catalyzed C-H arylation directed by tetrazole, a metabolically stable surrogate for the carboxylic acid group in drug design, has been developed. Excellent mono-/di-selectivity was achieved through adjustment of the protecting site on the tetrazole ring. The synthetic utility of this new transformation was demonstrated in the concise total synthesis of Losartan.
authors: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China. xswang77@ustc.edu.cn.
authors: Yan-Jun
authors: YJ
authors: Ding
authors: Yan
authors: Y
authors: Li
authors: Sheng-Yu
authors: SY
authors: Dai
authors: Quan
authors: Q
authors: Lan
authors: Xi-Sheng
authors: XS
authors: Wang
mesh_terms: D002384:Catalysis; D019808:Losartan / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D013777:Tetrazoles; D010165:Palladium; D019808:Losartan