title: High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test.
abstract: OBJECTIVE
  To assess the vitamin A status of patients with Crohn's disease (CD) by evaluating serum retinol levels and the relative dose response (RDR) test (liver retinol stores).
  
  
  METHODS
  Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores. Body composition was performed by densitometry by dual-energy X-ray absorptiometry. Vitamin A dietary intake was assessed from a semi-quantitative food frequency questionnaire.
  
  
  RESULTS
  This study included 38 CD patients and 33 controls. Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls (P < 0.005). The RDR test was positive in 37% of CD patients vs 12% in controls, which indicated inadequate hepatic vitamin A stores (P < 0.005). Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency. There was no association between vitamin A deficiency and its dietary intake, ileal location, presence of disease activity and prior bowel resections.
  
  
  CONCLUSIONS
  Patients with CD have higher prevalence of vitamin A deficiency, as assessed by two independent methods.
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Márcia
authors: M
authors: Soares-Mota
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Tianny A
authors: TA
authors: Silva
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Luanda M
authors: LM
authors: Gomes
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Marco A S
authors: MA
authors: Pinto
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Laura M C
authors: LM
authors: Mendonça
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Maria Lúcia F
authors: ML
authors: Farias
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Tiago
authors: T
authors: Nunes
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Andrea
authors: A
authors: Ramalho
authors: Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
authors: Cyrla
authors: C
authors: Zaltman
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008099:Liver / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D011237:Predictive Value of Tests; D015995:Prevalence; D011795:Surveys and Questionnaires; D014801:Vitamin A / Q000097:blood*; D014802:Vitamin A Deficiency / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D014801:Vitamin A
keywords: Body composition; Crohn’s disease; Relative dose response test; Serum retinol; Vitamin A