title: Sensing viral RNAs by Dicer/RIG-I like ATPases across species.
abstract: Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex RNA activated ATPase, or DRA domain, plays an important role in viral RNA sensing. Crystallographic and electron microscopy studies of the RIG-I and Dicer DRA domains indicate a common structure and that similar conformational changes are induced by dsRNA binding. Genetic and biochemical studies on the function and regulation of DRAs reveal similarities, but also some differences, between viral RNA sensing mechanisms in nematodes, flies and mammals.
authors: Antiviral Immunity Group, CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
authors: Simona
authors: S
authors: Paro
authors: Antiviral Immunity Group, CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, Strasbourg, France.
authors: Jean-Luc
authors: JL
authors: Imler
authors: Antiviral Immunity Group, CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, Strasbourg, France. Electronic address: c.meignin@unistra.fr.
authors: Carine
authors: C
authors: Meignin
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism*; D043244:Ribonuclease III / Q000737:chemistry / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology* / Q000378:metabolism*; D014780:Viruses / Q000276:immunology*
chemical_list: D012367:RNA, Viral; D043244:Ribonuclease III; D000251:Adenosine Triphosphatases; D053487:DEAD-box RNA Helicases