title: Reduced length of stay in radical cystectomy patients with oral versus parenteral post-operative nutrition protocol.
abstract: BACKGROUND
  In Europe, parenteral nutrition is often used after radical cystectomy to avoid postoperative malnourishment. To the best of our knowledge, however, there is a paucity of data to conclude on the best modality for delivering nutritional support to this patient group.
  
  
  OBJECTIVE
  The parenteral nutrition policy was reconsidered and an oral nutrition protocol was implemented by the clinical pharmacist and evaluated in terms of length of stay, number and type of postoperative complications and parenteral nutrition avoided costs.
  
  
  METHODS
  A prospective interventional non-randomized before-after study was conducted. Regular radical cystectomy patients presenting without preoperative contra-indications for enteral nutrition were eligible.
  
  
  METHODS
  Postoperatively, in the control group, the parenteral nutrition policy from the ward was applied. Parenteral nutrition was initiated systematically and continued until the patient was able to tolerate solid food. In the interventional group, an oral nutrition protocol was implemented. Parenteral nutrition could be initiated if oral intake remained insufficient after 5 days. Main outcome measure The primary end point was postoperative length of stay. Secondary endpoints included the number of patients in whom the oral nutrition protocol was implemented successfully, as well as the number and type of postoperative complications.
  
  
  RESULTS
  A total of 94 eligible patients was assigned consecutively to the control (n = 48) and to the interventional group (n = 46). Baseline demographics were comparable. A significant reduction in median length of stay was associated with the oral nutrition protocol [18 days (IQR 15-22) in the control group vs. 14 days (IQR 13-18) in the interventional group (p < 0.001)]. In 40 out of 46 patients from the interventional group, the oral nutrition protocol was implemented successfully. The number and type of postoperative complications did not differ significantly. Implementing the oral nutrition protocol resulted in a direct parenteral nutrition infusion bag cost saving of approximately €512 and a reduction in hospitalization cost of €2,608 per patient.
  
  
  CONCLUSIONS
  The findings of our study showed that an oral nutrition protocol, when compared to the systematic postoperative use of parenteral nutrition, was associated with a decreased length of stay and costs in a regular radical cystectomy patient population.
authors: Pharmacy Department, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium, peter.declercq@uzleuven.be.
authors: Peter
authors: P
authors: Declercq
authors: Gunter
authors: G
authors: De Win
authors: Frank
authors: F
authors: Van der Aa
authors: Elodie
authors: E
authors: Beels
authors: Beels
authors: B
authors: Elodie
authors: Lorenz
authors: L
authors: Van der Linden
authors: Hendrik
authors: H
authors: Van Poppel
authors: Ludo
authors: L
authors: Willems
authors: Willems
authors: W
authors: Ludo
authors: Isabel
authors: I
authors: Spriet
authors: Spriet
authors: S
authors: Isabel
mesh_terms: D000368:Aged; D015653:Cystectomy / Q000639:trends; D004750:Enteral Nutrition / Q000379:methods* / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay / Q000639:trends; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000379:methods* / Q000639:trends; D011182:Postoperative Care / Q000379:methods* / Q000639:trends; D011446:Prospective Studies; D016896:Treatment Outcome