title: The impact of Xpert® MTB/RIF depends on service coordination: experience in Burkina Faso.
abstract: Translating the potential of Xpert(®) MTB/RIF into more effective tuberculosis (TB) care and control in low-income settings is challenged by operational issues. We report the experience in introducing this technology in Burkina Faso through a centralised approach. Xpert was successfully integrated into the diagnostic algorithm of multidrug-resistant TB cases. However, barriers to Xpert use for the diagnosis of TB in vulnerable populations, such as persons living with human immunodeficiency virus infection and children, were observed, mainly due to lack of coordination between services. Lessons learnt can be exploited to optimise the roll-out of this technology at country level.
authors: <sup>*</sup>National Tuberculosis Program, Ministry of Health, Ouagadougou, Burkina Faso.
authors: I
authors: I
authors: Moyenga
authors: <sup>†</sup>University Division of Infectious and Tropical Disease, World Health Organization (WHO) Collaborating Centre for TB/HIV Activities and for TB Elimination, University of Brescia, Brescia.
authors: A
authors: A
authors: Roggi
authors: <sup>†</sup>University Division of Infectious and Tropical Disease, World Health Organization (WHO) Collaborating Centre for TB/HIV Activities and for TB Elimination, University of Brescia, Brescia.
authors: G
authors: G
authors: Sulis
authors: <sup>*</sup>National Tuberculosis Program, Ministry of Health, Ouagadougou, Burkina Faso.
authors: S
authors: S
authors: Diande
authors: <sup>*</sup>National Tuberculosis Program, Ministry of Health, Ouagadougou, Burkina Faso.
authors: D
authors: D
authors: Tamboura
authors: <sup>‡</sup>Emerging Pathogens Unit, TB Supranational Reference laboratory, San Raffaele Scientific Institute, Milan, Italy.
authors: E
authors: E
authors: Tagliani
authors: <sup>†</sup>University Division of Infectious and Tropical Disease, World Health Organization (WHO) Collaborating Centre for TB/HIV Activities and for TB Elimination, University of Brescia, Brescia.
authors: F
authors: F
authors: Castelli
authors: <sup>§</sup>Global TB Programme, TB/HIV and Community Engagement Unit, WHO, Geneva, Switzerland.
authors: A
authors: A
authors: Matteelli
mesh_terms: D002050:Burkina Faso; D024901:Drug Resistance, Multiple, Bacterial; D005240:Feasibility Studies; D015658:HIV Infections; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000628:therapy / Q000821:virology