title: Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients.
abstract: The aim of the present study was to investigate the prognostic value of different pretreatment platelet (PLT) counts on the treatment outcome in nasopharyngeal carcinoma (NPC) patients receiving concurrent chemoradiotherapy (CCRT) or radiotherapy (RT) alone. A total of 1,501 NPC patients, including 412 receiving CCRT and 1,089 receiving RT, were enrolled in the present study. The PLT count cut-off points for the CCRT and RT groups were 150 and 300×109/l, respectively, and the PLT counts were categorized it into three groups: Low (PLT≤150×109/l), moderate (150×109/l<PLT≤300×109/l) and high (PLT>300×109/l). To identify independent predictors of overall survival (OS), the Cox proportional hazards model was used to determine local-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) rates in the CCRT and RT patients. Furthermore, univariate and multivariate analysis indicated that compared with a moderate PLT count, a low PLT count was an independent unfavorable prognostic factor for OS rate in CCRT patients [hazard ratio (HR), 2.024; 95% confidence interval (CI), 1.165-3.516], and a high PLT count was an independent unfavorable prognostic factor for OS and DMFS rates in CCRT (OS: HR, 1.742; 95% CI, 1.090-2.786; DFMS: HR, 2.110; 95%CI, 1.084-4.108) and RT (OS: HR, 1.740; 95%CI, 1.283-2.362; DMFS: HR, 2.819; 95% CI, 1.766-4.497) patients. Compared with a low PLT count, a high PLT count was significantly and independently associated with a poor DMFS rate in the RT patients (P=0.025; HR, 2.454; 95% CI, 1.121-5.372). Therefore, the present study indicates that low and high PLT counts may be useful indicators of survival and distant metastasis in NPC patients who have undergone radiation treatment.
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Yu-Pei
authors: YP
authors: Chen
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Chen
authors: C
authors: Chen
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Zhuo-Yao
authors: ZY
authors: Mai
authors: Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, Anhui, P.R. China.
authors: Jin
authors: J
authors: Gao
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Lu-Jun
authors: LJ
authors: Shen
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Bing-Cheng
authors: BC
authors: Zhao
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Meng-Kun
authors: MK
authors: Chen
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Gang
authors: G
authors: Chen
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Fang
authors: F
authors: Yan
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Tong-Yi
authors: TY
authors: Huang
authors: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China ; Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.
authors: Yun-Fei
authors: YF
authors: Xia
keywords: concurrent chemoradiotherapy; nasopharyngeal carcinoma; platelet count; predictor; prognosis; radiotherapy