title: Fibroblast growth factors stimulate hair growth through β-catenin and Shh expression in C57BL/6 mice.
abstract: Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth. The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action. We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice. Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group. Moreover, the immunohistochemical analysis reveals earlier induction of β-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.
authors: Department of Nurse, The first Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China.
authors: Wei-hong
authors: WH
authors: Lin
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Li-Jun
authors: LJ
authors: Xiang
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Hong-Xue
authors: HX
authors: Shi
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Jian
authors: J
authors: Zhang
authors: School of Nurse, Wenzhou Medical University, Wenzhou 325035, China.
authors: Li-ping
authors: LP
authors: Jiang
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Ping-tao
authors: PT
authors: Cai
authors: Department of Pediatrics, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.
authors: Zhen-Lang
authors: ZL
authors: Lin
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Bei-Bei
authors: BB
authors: Lin
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Yan
authors: Y
authors: Huang
authors: Department of Pediatrics, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.
authors: Hai-Lin
authors: HL
authors: Zhang
authors: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing 100853, China.
authors: Xiao-Bing
authors: XB
authors: Fu
authors: Department of General Surgery, Cixi People's Hospital, Wenzhou Medical University, Ningbo, China.
authors: Ding-Jiong
authors: DJ
authors: Guo
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Xiao-Kun
authors: XK
authors: Li
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Xiao-Jie
authors: XJ
authors: Wang
authors: Molecular Pharmacology Research Center, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
authors: Jian
authors: J
authors: Xiao
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D018859:Hair Follicle / Q000254:growth & development*; D053823:Hedgehog Proteins / Q000096:biosynthesis*; D051379:Mice; D051176:beta Catenin / Q000096:biosynthesis*
chemical_list: D053823:Hedgehog Proteins; C465570:Shh protein, mouse; D051176:beta Catenin; D005346:Fibroblast Growth Factors