title: Coffee bean polyphenols ameliorate postprandial endothelial dysfunction in healthy male adults.
abstract: To reveal the effect of coffee bean polyphenols (CBPs) on blood vessels, this study aimed to investigate the effect of CBPs on acute postprandial endothelial dysfunction. Thirteen healthy non-diabetic men (mean age, 44.9 ± 1.4 years) consumed a test beverage (active: containing CBPs, placebo: no CBPs) before a 554-kcal test meal containing 14 g of protein, 30 g of fat and 58 g of carbohydrates. Then, a crossover analysis was performed to investigate the time-dependent changes in flow-mediated dilation (FMD) in the brachial artery. In the active group, the postprandial impairment of FMD was significantly improved, the two-hour postprandial nitric oxide metabolite levels were significantly increased and the six-hour postprandial urinary 8-epi-prostaglandin F2α levels were significantly reduced compared to the placebo group. The test meal increased the levels of blood glucose, insulin and triglycerides in both groups with no significant intergroup differences. These findings indicate that CBPs intake ameliorates postprandial endothelial dysfunction in healthy men.
authors: Health Care Food Research Laboratories, Kao Corporation , Tokyo , Japan and.
authors: Ryuji
authors: R
authors: Ochiai
authors: Yoko
authors: Y
authors: Sugiura
authors: Kazuhiro
authors: K
authors: Otsuka
authors: Yoshihisa
authors: Y
authors: Katsuragi
authors: Teruto
authors: T
authors: Hashiguchi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001916:Brachial Artery / Q000187:drug effects / Q000503:physiopathology; D040503:Coffea / Q000737:chemistry; D003069:Coffee / Q000737:chemistry*; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D059808:Polyphenols / Q000494:pharmacology*; D019518:Postprandial Period; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D003069:Coffee; D007328:Insulin; D059808:Polyphenols; D014280:Triglycerides; C075750:8-epi-prostaglandin F2alpha; D009569:Nitric Oxide; D015237:Dinoprost
keywords: Chlorogenic acid; coffee; endothelial function; flow-mediated dilation; nitric oxide; polyphenol