title: MicroRNA-572 improves early post-operative cognitive dysfunction by down-regulating neural cell adhesion molecule 1.
abstract: Post-operative cognitive dysfunction (POCD) is a commonly-seen postoperative complication in elderly patients. However, the underlying mechanisms of POCD remain unclear. miRNAs, which are reported to be involved in the pathogenesis of the nervous system diseases, may also affect POCD. In this study, miRNA microarray technology was used to analyze the circulating miRNA expression profile of POCD patients. Among the altered miRNAs, miR-572 had the greatest decrease, which was also verified in vivo in rat POCD model. Further analysis found that miR-572 could regulate the expression of NCAM1 in the hippocampal neurons and interfering miR-572 expression could facilitate the restoration of cognitive function in vivo. Moreover, clinical correlation analysis found that the miR-572 expression was associated with the incidence of POCD. Collectively, miR-572 is involved in the development and restoration of POCD and it may serve as a biological marker for early diagnosis of POCD.
authors: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Xiya
authors: X
authors: Yu
authors: Clinical Research Center, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Shupeng
authors: S
authors: Liu
authors: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Jinbao
authors: J
authors: Li
authors: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Xiaohua
authors: X
authors: Fan
authors: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Yuanjie
authors: Y
authors: Chen
authors: Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Xiaoying
authors: X
authors: Bi
authors: Clinical Research Center, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Shanrong
authors: S
authors: Liu
authors: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
authors: Xiaoming
authors: X
authors: Deng
mesh_terms: D000367:Age Factors; D000368:Aged; D000818:Animals; D016000:Cluster Analysis; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology*; D004195:Disease Models, Animal; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D019006:Neural Cell Adhesion Molecules / Q000235:genetics*; D011183:Postoperative Complications / Q000235:genetics* / Q000523:psychology*; D034622:RNA Interference; D051381:Rats
chemical_list: C000603872:MIRN-572 microRNA, human; D035683:MicroRNAs; D019006:Neural Cell Adhesion Molecules