title: Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy.
abstract: Pregnancy-associated glycoproteins (PAGs) are abundantly expressed products of the placenta of species within the Cetartiodactyla order (even-toed ungulates). They are restricted to this order and they are particularly numerous in the Bovidae. The PAGs exhibit a range of temporal and spatial expression patterns by the placental trophoblasts and probably represent a group of related proteins that perform a range of distinct functions in the epitheliochorial and synepitheliochorial placental forms. This review presents an overview of the origins of the PAGs, a summary of PAG expression patterns, and their use as markers of pregnancy status. Speculations about their putative role(s) in pregnancy are also presented.
authors: Division of Animal Sciences163 Animal Sciences Research Center, University of Missouri, Columbia, Missouri 65211, USA.
authors: Rhianna M
authors: RM
authors: Wallace
authors: Division of Animal Sciences163 Animal Sciences Research Center, University of Missouri, Columbia, Missouri 65211, USA.
authors: Ky G
authors: KG
authors: Pohler
authors: Division of Animal Sciences163 Animal Sciences Research Center, University of Missouri, Columbia, Missouri 65211, USA.
authors: Michael F
authors: MF
authors: Smith
authors: Division of Animal Sciences163 Animal Sciences Research Center, University of Missouri, Columbia, Missouri 65211, USA greenjo@missouri.edu.
authors: Jonathan A
authors: JA
authors: Green
mesh_terms: D000818:Animals; D001188:Artiodactyla / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D011257:Pregnancy Proteins