title: Herpes esophagitis in the setting of immunosuppression from pemphigus vulgaris therapy.
abstract: We report a case of herpes esophagitis in a 35-year-old man with pemphigus vulgaris (PV) who was undergoing treatment with corticosteroids and mycophenolate mofetil (MMF). Pemphigus vulgaris is an autoimmune intraepithelial bullous disease resulting from pathogenic IgG antibodies toward desmoglein antigens that often requires long-term immunosuppressive therapy for control of disease symptoms. Herpes esophagitis is an ulcerative eruption caused by viral reactivation in the setting of immunosuppression. Acute odynophagia in patients undergoing systemic treatment of active PV has a broad differential and warrants prompt endoscopic evaluation.
authors: Noah H
authors: NH
authors: Kahn
authors: Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, 8825 Bee Cave Rd, Ste 100, Austin, TX 78746, USA. daniel@westlakedermatology.com.
authors: Daniel P
authors: DP
authors: Friedmann
authors: Charles M
authors: CM
authors: Phillips
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D004941:Esophagitis / Q000139:chemically induced* / Q000188:drug therapy / Q000821:virology*; D004945:Esophagoscopy; D006561:Herpes Simplex / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010392:Pemphigus / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D000212:Acyclovir