title: Harmonised Australian Reference Intervals for Serum PINP and CTX in Adults.
abstract: Bone turnover markers (BTMs) are classified as either formation or resorption markers. Their concentrations in blood or urine of adults are considered to reflect the rate of bone remodelling and may be of use in the management of patients with bone disease. Major inter-method differences exist for BTMs, and harmonisation of methods is currently being pursued at an international level. Based on published data, this article describes age- and sex-specific Australian consensus reference intervals for adults for serum procollagen type I amino-terminal propeptide (s-PINP) and serum β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen (s-CTX).
authors: Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth and Fremantle Hospitals, Perth, WA, Australia; ; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia;
authors: Samuel D
authors: SD
authors: Vasikaran
authors: Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth and Fremantle Hospitals, Perth, WA, Australia; ; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia; ; School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia;
authors: Sa Paul
authors: SP
authors: Chubb
authors: Department of Medicine, School for Clinical Sciences, Faculty Medicine, Dentistry and Health Sciences, Monash University, Clayton, Vic., Australia;
authors: Peter R
authors: PR
authors: Ebeling
authors: Clinical Biochemistry Unit, Alfred Pathology Service, Melbourne, Australia;
authors: Nicole
authors: N
authors: Jenkins
authors: Department of Chemical Pathology, SydPath, St Vincent's Hospital, Darlinghurst, NSW, Australia; ; University of NSW, Kensington, NSW, Australia;
authors: Graham Rd
authors: GR
authors: Jones
authors: School of Medicine, Deakin University, Geelong, Vic., Australia; ; NorthWest Academic Centre, The University of Melbourne, Sunshine Hospital, St Albans, Vic., Australia; ; Department of Endocrinology & Diabetes, Barwon Health, Geelong, Vic., Australia;
authors: Mark A
authors: MA
authors: Kotowicz
authors: School of Pharmacy and Medical Sciences, University of South Australia, SA, Australia; ; Chemical Pathology Directorate and Hanson Institute, SA Pathology, Adelaide, SA, Australia;
authors: Howard A
authors: HA
authors: Morris
authors: Clinical Biochemistry Unit, Alfred Pathology Service, Melbourne, Australia; ; Monash University, Melbourne, Vic., Australia;
authors: Hans-Gerhard
authors: HG
authors: Schneider
authors: Bone Research Program, ANZAC Research Institute, Sydney, NSW, Australia; ; Department of Endocrinology & Metabolism, Concord Hospital, Sydney, NSW, Australia; ; The University of Sydney, Sydney, NSW, Australia;
authors: Markus J
authors: MJ
authors: Seibel
authors: Biochemistry & Endocrinology, Sullivan & Nicolaides Pathology, Brisbane, Qld, Australia.
authors: Greg
authors: G
authors: Ward