title: Affected connectivity organization of the reward system structure in obesity.
abstract: With the prevalence of obesity rapidly increasing worldwide, understanding the processes leading to excessive eating behavior becomes increasingly important. Considering the widely recognized crucial role of reward processes in food intake, we examined the white matter wiring and integrity of the anatomical reward network in obesity. Anatomical wiring of the reward network was reconstructed derived from diffusion weighted imaging in 31 obese participants and 32 normal-weight participants. Network wiring was compared in terms of the white matter volume as well as in terms of white matter microstructure, revealing lower number of streamlines and lower fiber integrity within the reward network in obese subjects. Specifically, the orbitofrontal cortex and striatum nuclei including accumbens, caudate and putamen showed lower strength and network clustering in the obesity group as compared to healthy controls. Our results provide evidence for obesity-related disruptions of global and local anatomical connectivity of the reward circuitry in regions that are key in the reinforcing mechanisms of eating-behavior processes.
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Institute for Brain, Cognition and Behavior (IR3C), Barcelona, Spain.
authors: I
authors: I
authors: Marqués-Iturria
authors: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: L H
authors: LH
authors: Scholtens
authors: Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain; Neuropsychology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain.
authors: M
authors: M
authors: Garolera
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Institute for Brain, Cognition and Behavior (IR3C), Barcelona, Spain; Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain.
authors: R
authors: R
authors: Pueyo
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors: I
authors: I
authors: García-García
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
authors: P
authors: P
authors: González-Tartiere
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain.
authors: B
authors: B
authors: Segura
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain.
authors: C
authors: C
authors: Junqué
authors: CAP Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Spain.
authors: M J
authors: MJ
authors: Sender-Palacios
authors: CAP Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Spain.
authors: M
authors: M
authors: Vernet-Vernet
authors: Pediatric Endocrinology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain.
authors: C
authors: C
authors: Sánchez-Garre
authors: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: M A
authors: MA
authors: de Reus
authors: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain; Institute for Brain, Cognition and Behavior (IR3C), Barcelona, Spain; Grup de Recerca Consolidat en Neuropsicologia, Barcelona, Spain. Electronic address: majurado@ub.edu.
authors: M A
authors: MA
authors: Jurado
authors: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: M P
authors: MP
authors: van den Heuvel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D017072:Neostriatum / Q000473:pathology*; D009415:Nerve Net / Q000473:pathology*; D009765:Obesity / Q000473:pathology*; D017397:Prefrontal Cortex / Q000473:pathology*; D012201:Reward; D066127:White Matter / Q000473:pathology*
keywords: Body mass index; Diffusion imaging; Eating; Neuroanatomy; Orbitofrontal cortex; Striatum