title: Trends in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of synchronous peritoneal carcinomatosis of colorectal origin in the Netherlands.
abstract: BACKGROUND
  Population-based data on the percentage of colorectal cancer (CRC) patients with synchronous peritoneal carcinomatosis (PC) being treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are currently lacking. The current population-based study describes trends in the use of CRS-HIPEC in the Netherlands, one of the first countries where CRS and HIPEC was introduced.
  
  
  METHODS
  All patients diagnosed with synchronous PC of CRC between 2005 and 2012 were extracted from the Netherlands Cancer Registry (n = 4623). Patients with primary appendiceal cancer were excluded resulting in a study population of 4430 patients. Trends in the use of CRS-HIPEC over time were analyzed by means of a Cochrane-Armitage trend test. Survival proportions were calculated as the time between diagnosis and date of death or last follow-up (January 2014).
  
  
  RESULTS
  Of the total 4430 patients with synchronous PC, 297 (6.4%) underwent treatment with CRS-HIPEC. The proportion of colorectal PC patients receiving CRS-HIPEC increased significantly over time from 3.6% in 2005-2006 to 9.7% in 2011-2012 (p < 0.0001). Overall median survival (MS) for patients treated with CRS-HIPEC was 32.3 months, whereas MS rates were respectively 12.6, 6.1 and 1.5 for months palliative chemotherapy with/without surgery, palliative surgery and best supportive care.
  
  
  CONCLUSIONS
  The proportion of patients diagnosed with synchronous PC from CRC treated with CRS-HIPEC has increased significantly over time and currently almost 10% of PC patients are treated with CRS-HIPEC. Median survival in this population based group is 32.3 months.
authors: Department of Oncology, Catharina Hospital, Eindhoven, The Netherlands; Eindhoven Cancer Registry/Netherlands Comprehensive Cancer Organisation (IKNL), Eindhoven, The Netherlands.
authors: L G E M
authors: LG
authors: Razenberg
authors: Eindhoven Cancer Registry/Netherlands Comprehensive Cancer Organisation (IKNL), Eindhoven, The Netherlands.
authors: Y R B M
authors: YR
authors: van Gestel
authors: Department of Oncology, Catharina Hospital, Eindhoven, The Netherlands.
authors: G-J
authors: GJ
authors: Creemers
authors: Department of Surgical Oncology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors: V J
authors: VJ
authors: Verwaal
authors: Eindhoven Cancer Registry/Netherlands Comprehensive Cancer Organisation (IKNL), Eindhoven, The Netherlands; Department of Public Health, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
authors: V E P P
authors: VE
authors: Lemmens
authors: Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands. Electronic address: ignace.d.hingh@catharinaziekenhuis.nl.
authors: I H J T
authors: IH
authors: de Hingh
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002277:Carcinoma / Q000556:secondary / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures / Q000639:trends*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000639:trends*; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010166:Palliative Care; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000601:surgery; D012042:Registries; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents
keywords: Colorectal cancer; Cytoreductive surgery (CRS); Hyperthermic intraperitoneal chemotherapy (HIPEC); Synchronous peritoneal carcinomatosis