title: A genome-wide association study of periodontitis in a Japanese population.
abstract: Periodontitis is a multifactorial disease in which bacterial, lifestyle, and genetic factors are involved. Although previous genetic association studies identified several susceptibility genes for periodontitis in European populations, there is little information for Asian populations. Here, we conducted a genome-wide association study and a replication study consisting of 2,760 Japanese periodontitis patients and 15,158 Japanese controls. Although single-nucleotide polymorphisms that surpassed a stringent genome-wide significance threshold (P < 5 × 10(-8)) were not identified, we found 2 suggestive loci for periodontitis: KCNQ5 on chromosome 6q13 (rs9446777, P = 4.83 × 10(-6), odds ratio = 0.82) and GPR141-NME8 at chromosome 7p14.1 (rs2392510, P = 4.17 × 10(-6), odds ratio = 0.87). A stratified analysis indicated that the GPR141-NME8 locus had a strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with a history of smoking. In conclusion, this study identified 2 suggestive loci for periodontitis in a Japanese population. This study should contribute to a further understanding of genetic factors for enhanced susceptibility to periodontitis.
authors: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan Department of Oral Rehabilitation, Division of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu-cho, Ishikari, Hokkaido, Japan.
authors: S
authors: S
authors: Shimizu
authors: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: Y
authors: Y
authors: Momozawa
authors: Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: A
authors: A
authors: Takahashi
authors: Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Tobetsu-cho, Ishikari, Hokkaido, Japan.
authors: T
authors: T
authors: Nagasawa
authors: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: K
authors: K
authors: Ashikawa
authors: Division of General Dentistry, University Hospital, Health Sciences University of Hokkaido, Ainosato, Sapporo, Hokkaido, Japan.
authors: Y
authors: Y
authors: Terada
authors: Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Y
authors: Y
authors: Izumi
authors: Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: H
authors: H
authors: Kobayashi
authors: Division of Internal Medicine, University Hospital, Health Sciences University of Hokkaido, Ainosato, Sapporo, Hokkaido, Japan.
authors: M
authors: M
authors: Tsuji
authors: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
authors: M
authors: M
authors: Kubo
authors: Department of Oral Rehabilitation, Division of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu-cho, Ishikari, Hokkaido, Japan furuichi@hoku-iryo-u.ac.jp.
authors: Y
authors: Y
authors: Furuichi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D007564:Japan; D051656:KCNQ Potassium Channels / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000145:classification / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D012907:Smoking; D013879:Thioredoxins / Q000235:genetics; D055815:Young Adult
chemical_list: D051656:KCNQ Potassium Channels; C412231:KCNQ5 protein, human; C452260:NME8 protein, human; D043562:Receptors, G-Protein-Coupled; D013879:Thioredoxins
keywords: Asians; SNPs; disease susceptibility; gene-environment interaction; periodontal disease; tobacco