title: Allogeneic donor availability for hematopoietic stem cell transplantation in children with sickle cell disease.
abstract: Hematopoietic stem cell transplant is curative of sickle cell disease (SCD) but limited by donor availability. Searches for 85 patients with SCD without matched sibling donors from 2009-2013 using modern techniques (allele-level HLA matching for unrelated donors and higher total nucleated cell doses for umbilical cord blood (UCB)) showed potential match probabilities of 20% for 8/8 HLA-matched unrelated donors, 84% for 7/8 donors, and 97% for two 4-6/6 UCBs suitable for ex-vivo expanded/double cord transplant. Searches performed by age 43 months would have a 90% chance of finding a suitable 5-6/6 UCB.
authors: School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia.
authors: David
authors: D
authors: Justus
authors: Division of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
authors: Evelio
authors: E
authors: Perez-Albuerne
authors: Division of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
authors: Jacqueline
authors: J
authors: Dioguardi
authors: Division of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
authors: David
authors: D
authors: Jacobsohn
authors: Division of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
authors: Allistair
authors: A
authors: Abraham
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D005260:Female; D005312:Fetal Blood; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009010:Monte Carlo Method; D011379:Prognosis; D012189:Retrospective Studies; D014019:Tissue Donors / Q000600:supply & distribution*; D014184:Transplantation, Homologous; D055815:Young Adult
keywords: BMT; sickle cell disease; transplantation