title: Effects of calcium phosphate nanocrystals on osseointegration of titanium implant in irradiated bone.
abstract: Radiotherapy may compromise the integration of implant and cause implant loss. Implant surface modifications have the possibility of promoting cell attachment, cell growth, and bone formation which ultimately enhance the osseointegration process. The present study aimed to investigate the effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were randomly assigned into control and nano-CaP groups, receiving implants with dual acid-etched surface or dual acid-etched surface discretely deposited of nanoscale calcium-phosphate crystals, respectively. The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after. Four animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 6, P = 0.021; week 9, P = 0.001) than that in control group. No significant differences in BV/TV and BIC were found between two groups. Titanium implant surface modified with CaP nanocrystals provides a potential alternative to improve bone healing around implant in irradiated bone.
authors: Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors: Jun Yuan
authors: JY
authors: Li
authors: Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors: Edmond Ho Nang
authors: EH
authors: Pow
authors: Oral Diagnosis and Polyclinics, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors: Li Wu
authors: 0000-0002-7593-0208
authors: LW
authors: Zheng
authors: Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors: Li
authors: 0000-0003-4305-3017
authors: L
authors: Ma
authors: Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors: Dora Lai Wan
authors: DL
authors: Kwong
authors: Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong.
authors: Lim Kwong
authors: LK
authors: Cheung
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D005720:Gamma Rays; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects / Q000528:radiation effects; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium / Q000737:chemistry*
chemical_list: D002130:Calcium Phosphates; C020243:calcium phosphate; D014025:Titanium