title: Bone cement based on vancomycin loaded mesoporous silica nanoparticle and calcium sulfate composites.
abstract: A novel bone cement pellet, with sustained release of vancomycin (VAN), was prepared by mixing VAN loaded mesoporous silica nanoparticle (MSN) and calcium sulfate α-hemihydrate (CS) together. To improve the VAN loading ability, MSN was functionalized with aminopropyltriethoxysilane (APS) to give APS-MSN. The VAN loading content and entrapment efficiency of APS-MSN could reach up to 45.91±0.81% and 84.88±1.52%, respectively, much higher than those of MSN, which were only 3.91% and 4.07%, respectively. The nitrogen adsorption-desorption measurement results demonstrated that most of the VAN were in the pores of APS-MSN. The CS/VAN@APS-MSN composite pellet showed a strongly drug sustained release effect in comparison with CS control pellet. The in vitro cell assays demonstrated that CS/APS-MSN composite was highly biocompatible and suitable to use as bone cement. Furthermore, CS/VAN@APS-MSN pellet showed no pyrogenic effect and meet the clinical requirements on hemolytic reaction. These results imply that CS/VAN@APS-MSN was an ideal candidate to replace CS bone cement in the treatment of open fractures.
authors: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
authors: Hanwen
authors: H
authors: Li
authors: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors: Jisheng
authors: J
authors: Gu
authors: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors: Luqman Ali
authors: LA
authors: Shah
authors: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors: Mohammad
authors: M
authors: Siddiq
authors: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
authors: Jianhua
authors: J
authors: Hu
authors: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: caixbjn@163.com.
authors: Xiaobing
authors: X
authors: Cai
authors: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China. Electronic address: yangdong@fudan.edu.cn.
authors: Dong
authors: D
authors: Yang
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D002133:Calcium Sulfate / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits; D012822:Silicon Dioxide / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D014640:Vancomycin; D012822:Silicon Dioxide; D002133:Calcium Sulfate
keywords: Bone cement; Bone grafting; Mesoporous silica nanoparticle; Sustained release; Vancomycin