title: Ovarian yolk formation in fishes: Molecular mechanisms underlying formation of lipid droplets and vitellogenin-derived yolk proteins.
abstract: Fish egg yolk is largely derived from vitellogenins, which are synthesized in the liver, taken up from the maternal circulation by growing oocytes via receptor-mediated endocytosis and enzymatically processed into yolk proteins that are stored in the ooplasm. Lipid droplets are another major component of fish egg yolk, and these are mainly composed of neutral lipids that may originate from maternal plasma lipoproteins. This review aims to briefly summarize our current understanding of the molecular mechanisms underlying yolk formation in fishes. A hypothetical model of oocyte growth is proposed based on recent advances in our knowledge of fish yolk formation.
authors: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan. Electronic address: naoshi@fish.hokudai.ac.jp.
authors: Naoshi
authors: N
authors: Hiramatsu
authors: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Takashi
authors: T
authors: Todo
authors: Carolina AquaGyn, P.O. Box 12914, Raleigh, NC 27605, USA.
authors: Craig V
authors: CV
authors: Sullivan
authors: Department of Biology, North Carolina State University, Raleigh, NC 27695-7617, USA; Department of Applied Ecology, North Carolina State University, Raleigh, NC 27695-7617, USA(1).
authors: Justin
authors: J
authors: Schilling
authors: Department of Biology, North Carolina State University, Raleigh, NC 27695-7617, USA; Department of Applied Ecology, North Carolina State University, Raleigh, NC 27695-7617, USA(1).
authors: Benjamin J
authors: BJ
authors: Reading
authors: South Ehime Fisheries Research Center, Ehime University, Ainan, Ehime 798-4206, Japan.
authors: Takahiro
authors: T
authors: Matsubara
authors: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan; South Ehime Fisheries Research Center, Ehime University, Ainan, Ehime 798-4206, Japan.
authors: Yong-Woon
authors: YW
authors: Ryu
authors: Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Hiroko
authors: H
authors: Mizuta
authors: Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan; Department of Genetics, SOKENDAI, Mishima 411-8540, Japan(1).
authors: Wenshu
authors: W
authors: Luo
authors: Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Osamu
authors: O
authors: Nishimiya
authors: Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Meiqin
authors: M
authors: Wu
authors: Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Yuji
authors: Y
authors: Mushirobira
authors: National Institute of Agronomic Research, Campus de Beaulieu, 35000 Rennes Cedex, France.
authors: Ozlem
authors: O
authors: Yilmaz
authors: Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
authors: Akihiko
authors: A
authors: Hara
mesh_terms: D000818:Animals; D004527:Egg Proteins / Q000378:metabolism*; D004530:Egg Yolk / Q000378:metabolism*; D005260:Female; D005399:Fishes / Q000378:metabolism*; D066292:Lipid Droplets / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D014819:Vitellogenins / Q000378:metabolism*
chemical_list: D004527:Egg Proteins; D014819:Vitellogenins
keywords: Fish; Lipoprotein receptors; Lipoproteins; Oocyte; Vitellogenins; Yolk