title: [Epilepsy and functional brain networks].
abstract: Recent resting-state functional MRI (rs-fMRI) studies have demonstrated that the human brain is composed of several essential large-scale functional brain networks, including the "default-mode network". We analyzed electrocorticogram data from four patients with intractable focal epilepsy and compared the extent of these large-scale functional brain networks with propagation pathways of ictal discharge. We found that large-scale functional brain networks had markedly similar spatial patterns compared with multisite ictal fast activity, suggesting that some epileptic activity propagates along large-scale functional brain networks. Given that decreased functional connectivity in large-scale functional brain networks has been reported in patients with focal epilepsy, ictal propagation may lead to chronic alteration of normal functional networks in the brain.
authors: Department of Neurology, Neurological Institute Graduate School of Medical Sciences, Kyushu University.
authors: Taira
authors: T
authors: Uehara
authors: Hiroshi
authors: H
authors: Shigeto
authors: Jun-ichi
authors: J
authors: Kira
mesh_terms: D001921:Brain / Q000502:physiology* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012146:Rest / Q000502:physiology