title: A patient with a noninvasive mucinous ovarian borderline tumor presenting with late pleural metastases.
abstract: We describe a patient diagnosed with a noninvasive intestinal-type mucinous ovarian borderline tumor presenting with pleural metastases 4 yr later. This was confirmed by an identical mutation in TP53 in both tumors. Metastases of ovarian borderline tumors outside the pelvis or abdominal cavity are extremely rare. A large epidemiologic search in the Dutch Pathology Registry that was conducted in support of this case, identifying 1812 intestinal-type mucinous ovarian borderline tumors, suggests that microinvasion is associated with a higher risk of disease spread. Our case illustrates that intestinal-type mucinous ovarian borderline tumor with intraepithelial carcinoma might also have a higher risk of metastasis, assuming that microinvasion occurs in the presence of intraepithelial carcinoma. Both intraepithelial carcinoma and microinvasion could be a trigger for more extensive tumor sampling to prevent sampling error of (micro)invasive adenocarcinoma. In addition, this case draws attention to the developmental spectrum of Types I and II ovarian carcinomas. Borderline tumors harboring a TP53 mutation require further studying to examine whether they might develop into high-grade Type II carcinomas.
authors: Departments of Pathology (M.S., I.D.N., U.F., J.B.) Obstetrics and Gynecology (L.F.M.), Radboud University Nijmegen Medical Centre, Nijmegen PALGA Foundation (L.I.O.), Utrecht, The Netherlands.
authors: Michiel
authors: M
authors: Simons
authors: Iris D
authors: ID
authors: Nagtegaal
authors: Lucy I
authors: LI
authors: Overbeek
authors: Uta
authors: U
authors: Flucke
authors: Leon F
authors: LF
authors: Massuger
authors: Johan
authors: J
authors: Bulten
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000556:secondary*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D010997:Pleural Neoplasms / Q000235:genetics / Q000556:secondary*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53