title: Hypervalent-iodine-mediated cascade annulation of diarylalkynes forming spiro heterocycles under metal-free conditions.
abstract: An unusual reaction featuring the cascade annulation of internal alkynes to afford spiro heterocycles as the products has been realized for the first time with a hypervalent iodine reagent as the only oxidant. This unprecedented process encompasses not only two sequential C-N/C-O-bond formations, but also the insertion of a carbonyl oxygen, all in one pot under metal-free conditions.
authors: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-2740-4031.
authors: Xiang
authors: X
authors: Zhang
authors: Chao
authors: C
authors: Yang
authors: Daisy
authors: D
authors: Zhang-Negrerie
authors: Yunfei
authors: Y
authors: Du
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D013141:Spiro Compounds; D007455:Iodine
keywords: annulation; domino reactions; hypervalent iodine; reaction mechanisms; spiro compounds