title: Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China.
abstract: OBJECTIVE
  Chronic levodopa (L-dopa) treatment in Parkinson's disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The present survey was to investigate the prevalence rate of wearing-off (WO) and dyskinesia among the patients with PD in China.
  
  
  METHODS
  From May 2012 to October 2012, a 3-step registry survey for wearing off (WO) and dyskinesia patients with PD receiving levodopa therapy was performed simultaneously at 28 movement disorders clinics in China.
  
  
  RESULTS
  There were 1,558 PD patients fulfilling the inclusion criteria. Among them, 1,051 had at least one positive response of 9-item wearing off questionnaire (WOQ-9), 724 and 160 patients were finally diagnosed with WO and dyskinesia by movement disorders specialists, respectively. The overall prevalence rates of WO and dyskinesia were 46.5% (95% CI 44.0% - 48.9%) and 10.3% (95% CI 8.8% - 11.8%), respectively. The mean score of WOQ-9 for those with WO was 3.8 (SD = 1.8), with movement slowness being the most common motor symptoms and pain/aching being the most common non-motor symptoms. Better improvement of motor symptoms (n = 354, 87.8%) and long-term disease control and drug selection (n = 288, 71.5%) were the two most frequently considered factors when movement disorders specialists adjusted therapeutic strategies for patients with WO.
  
  
  CONCLUSIONS
  This survey provided the first multi-center epidemiological data of motor complications among PD patients on L-dopa therapy from mainland China. WO prevalence rate among Chinese PD patients was in line with, while dyskinesia prevalence rate was lower than previous reports from other Countries.
authors: Department of Neurology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Rui Jin 2nd Road 197, Shanghai, 200025 China.
authors: Wei
authors: W
authors: Chen
authors: Department of Neurology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Rui Jin 2nd Road 197, Shanghai, 200025 China.
authors: Qin
authors: Q
authors: Xiao
authors: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China.
authors: Ming
authors: M
authors: Shao
authors: Department of Neurology, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, China.
authors: Tao
authors: T
authors: Feng
authors: Department of Neurology, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, China.
authors: Wei-Guo
authors: WG
authors: Liu
authors: Department of Neurology, The First Hospital of China Medical University, Shenyang, China.
authors: Xiao-Guang
authors: XG
authors: Luo
authors: Department of Neurology, Union XieHe Hospital, Fujian Medical University, Fuzhou, China.
authors: Xiao-Chun
authors: XC
authors: Chen
authors: Department of Neurology, The Affiliated Hospital of Medical College Qingdao University, Qingdao, China.
authors: An-Mu
authors: AM
authors: Xie
authors: Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors: Chun-Feng
authors: CF
authors: Liu
authors: Department of Neurology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Zhen-Guo
authors: ZG
authors: Liu
authors: Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
authors: Yi-Ming
authors: YM
authors: Liu
authors: Department of Neurology, Huashan Hospital affiliated to Fudan University, Shanghai, China.
authors: Jian
authors: J
authors: Wang
authors: Department of Neurology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Rui Jin 2nd Road 197, Shanghai, 200025 China.
authors: Sheng-Di
authors: SD
authors: Chen
keywords: Dyskinesia; Epidemiology; Parkinson’s disease; Wearing-off