title: Endocrine and reproductive effects of polycystic ovarian syndrome.
abstract: Management strategies for overweight and obese women with polycystic ovarian syndrome (PCOS) who desire fertility should include weight loss. Even a small reduction in body weight can improve ovulatory function and pregnancy rate and reduce adverse obstetric outcomes. New data suggest that letrozole should be considered as the new first-line medical treatment of anovulatory infertility in PCOS over clomiphene citrate. Second-line treatments for anovulatory infertility include in vitro fertilization, gonadotropins, or ovarian drilling.
authors: Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA.
authors: Laura C
authors: LC
authors: Ecklund
authors: Reproductive Endocrinology and Infertility, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA. Electronic address: Rebecca.Usadi@carolinashealthcare.org.
authors: Rebecca S
authors: RS
authors: Usadi
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D000077289:Letrozole; D009570:Nitriles / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D011247:Pregnancy; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole
keywords: Clomiphene citrate; Infertility; Letrozole; Live birth rate; Polycystic ovary syndrome; Reproductive endocrinology