title: Variation in the chicken LPIN2 gene and association with performance traits.
abstract: The objective of the study was to investigate the distribution of LPIN2 variants and haplotypes among breeds and perform an association analysis of the variants and haplotypes with the broiler traits in chickens. Six breeds were used to study the variation and distribution of chicken LPIN2, and an F2 resource population was used to measure growth traits, carcass traits, meat quality traits and serum biochemistry parameters. A c.-599G>A variant was located in the promoter region of LPIN2 and c.444G>A and c.1730A>T (E577D) coding variant mutations were detected. Linkage disequilibrium tests showed that these three variants were under moderate linkage disequilibrium in the 6 breeds and 7 haplotypes were constructed. The distribution of variation/haplotypes presented clear differences among breeds. Association analysis showed that c.-599G>A was associated with leg muscle weight, jejunum length, ileum length, leg muscle fibre density and leg muscle fibre diameter; c.444G>A was associated with spleen weight, ileum length, body weight at hatch and metatarsus length at 8 weeks; c.1730T>A had significant effects on chicken liver weight, heart weight, body weight at 10 weeks, serum albumin and glucose. Diplotypes were significantly associated with body weight at hatch, heart weight, pancreas weight, duodenum length, leg muscle fibre density and lactate dehydrogenase.
authors: a College of Livestock Husbandry and Veterinary Engineering , Henan Agricultural University , Zhengzhou , Henan , P. R. China.
authors: Y
authors: Y
authors: Huang
authors: C
authors: C
authors: Zhang
authors: W
authors: W
authors: Zhang
authors: P
authors: P
authors: Zhang
authors: X
authors: X
authors: Kang
authors: W
authors: W
authors: Chen
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D002645:Chickens / Q000235:genetics / Q000502:physiology*; D014644:Genetic Variation; D006239:Haplotypes; D015810:Linkage Disequilibrium; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D009929:Organ Size / Q000235:genetics
chemical_list: D009687:Nuclear Proteins