title: Serum cancer antigen 15.3 concentrations in patients with betathalassemia minor compared to those with cancer and healthy individuals.
abstract: BACKGROUND
  High serum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals.
  
  
  METHODS
  This cross-sectional study was done from February to December 2011 in Southern Iran. Participants consisted of 32 subjects with beta-thalassemia minor, 49 with cancer and 25 healthy individuals. The serum levels of CA15.3 were measured and compared in different groups.
  
  
  RESULTS
  The serum levels of CA 15.3 in all participants were in the normal range (<35 U/mL). Also it did not significantly differ among various groups of the participants (p=0.723). Age was not significantly correlated with the serum level of CA 15.3 (r= 0.039, p=0.702). The most frequent cancer in the group of patients with malignancies was hematologic malignancies (96%) with the highest frequency for acute lymphoblastic leukemia (37 patients). Frequency of thalassemia minor in patients with cancer was 11 (22.4%).
  
  
  CONCLUSIONS
  No correlation was found between CA 15.3 serum level with beta-thalssemia minor or with childhood malignancies. Compared to general population, a high proportion of beta-thalssemia minor was observed in patients with cancer in our study. Future prospective studies are needed to evaluate the relationship between cancer and beta-thalassemia minor accurately.
authors: 1. MD, Associate Professor, Pediatric Hematology - Oncology Department, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. shahryar@sums.ac.ir.
authors: Mahdi
authors: M
authors: Shahriari
authors: 2. MD, MPH, Assistant Professor, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. haghpanah@sums.ac.ir.
authors: Sezaneh
authors: S
authors: Haghpanah
authors: 3. MS. of Hematology, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. javaddehghani1978@gmail.com.
authors: Javad
authors: J
authors: Dehghani
authors: 4. PhD in laboratory, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. javad_dehbozorgian@yahoo.com.
authors: Javad
authors: J
authors: Dehbozorgian
authors: 5. MD, Assistant Professor, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. silavi90@gmail.com.
authors: Peyman
authors: P
authors: Eatemadfar
authors: 6. MD, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. bazrafsha@sums.ac.ir.
authors: Asghar
authors: A
authors: Bazrafshan
authors: 7. MD, Professor of Pediatric Hematology-Oncology, Hematology Research center, Shiraz University of Medical Sciences, Shiraz, Iran. Karimim@sums.ac.ir.
authors: Mehran
authors: M
authors: Karimi
keywords: Beta-thalassemia minor; Cancer; Cancer antigen 15.3