title: Risk factors of refeeding intolerance in mild acute interstitial pancreatitis: a retrospective study of 323 patients.
abstract: OBJECTIVE
  This study was aimed to access the frequency and identify independent risk factors of refeeding intolerance in patients with mild acute interstitial pancreatitis.
  
  
  METHODS
  Patients with mild acute pancreatitis (AP) were included in this observational, descriptive, and retrospective study. Clinical variables, therapy-related variables, and biochemical and radiological variables were analyzed by univariate and multivariate analysis.
  
  
  RESULTS
  Of 323 included cases, 40 patients (12.4%) developed refeeding intolerance. In the final regression model, hypertriglyceridemia-induced AP (odds ratio, 7.72; 95% CI: 2.50-23.82, P < 0.001), elevated serum lipase (>2-fold of the upper limit of normal) before refeeding (odds ratio, 2.13; 95% CI: 1.2-3.77, P = 0.009), and immediate feeding (odds ratio, 1.75; 95% CI: 1.31-2.33, P < 0.001) were critical risk factors of refeeding intolerance.
  
  
  CONCLUSIONS
  Refeeding intolerance occurs in 12.4% patients with mild AP and appears more often in those with hypertriglyceridemia-induced AP, elevated serum lipase (>2-fold of the upper limit of normal) before refeeding, and immediate feeding.
authors: Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors: Tingting
authors: T
authors: Ren
authors: Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors: Zhiqiang
authors: Z
authors: Shi
authors: Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors: Jiajia
authors: J
authors: Tang
authors: Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
authors: Hui
authors: H
authors: Wu
authors: Department of Anesthesiology & Intensive Care Unit, South Branch, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: hezhenzhouicu@163.com.
authors: Zhenzhou
authors: Z
authors: He
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D018529:Nutritional Support / Q000009:adverse effects*; D009765:Obesity / Q000150:complications; D010146:Pain / Q000209:etiology; D010195:Pancreatitis / Q000150:complications* / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D008049:Lipase
keywords: Acute pancreatitis; Feeding; Hypertriglyceridemia; Lipase; Mild AP; Pancreatic rest