title: The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells.
abstract: We investigated the possible presence of functional human chorionic gonadotropin (hCG)/luteinizing hormone (LH) receptors in β-cells of pancreas, using a combination of techniques on hCG/LH receptor knockout mice, immortalized rat insulinoma cells, and human pancreatic islets. The results showed the presence of receptors and their activation resulted in a dose-dependent increase in glucose-induced release of insulin. These findings place hCG and LH among the regulators of insulin release with potential implications for insulin-level changes during the periods of altered hCG and LH secretion.
authors: Department of Environmental and Occupational Health, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA Keiser University, Fort Myers, FL, USA.
authors: Jai
authors: J
authors: Parkash
authors: Department of Obstetrics and Gynecology, University of Louisville Medical Center, Louisville, KY, USA.
authors: Zhenmin
authors: Z
authors: Lei
authors: Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA crao@fiu.edu.
authors: C V
authors: CV
authors: Rao
mesh_terms: D000818:Animals; D002102:Cadaver; D045744:Cell Line, Tumor; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism*; D018345:Mice, Knockout; D051381:Rats; D011974:Receptors, LH / Q000819:agonists / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D046509:Tissue Culture Techniques
chemical_list: D006063:Chorionic Gonadotropin; D007328:Insulin; D011974:Receptors, LH; D005947:Glucose
keywords: colocalization; glucose; hCG/LH receptors; insulin release; β-cells of pancreas