title: Bioequivalence Study of Atorvastatin Tablets in Healthy Pakistani Volunteers.
abstract: A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers (N = 24). A high performance liquid chromatography method was employed to determine the level of drug in human plasma. It was concluded that the test and the reference drug exhibited comparable values of pharmacokinetic parameters. It was also concluded that since there was no significant difference between the rate and extent of absorption of the drug from the test and the reference formulations: these two formulations could thus be declared bioequivalent.
authors: College of Pharmacy, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
authors: Sohail
authors: S
authors: Mohammad
authors: College of Pharmacy, Government College University, Faisalabad, Pakistan.
authors: Usman
authors: U
authors: Arshad
authors: Department of Pharmacy, University of the Punjab, Lahore, Pakistan.
authors: Nasir
authors: N
authors: Abbass
authors: Department of Pharmacy, Comsats Institute of Information Technology, Abbottabad, Pakistan.
authors: Irfan
authors: I
authors: Parvez
authors: Department of Pharmacy, Comsats Institute of Information Technology, Abbottabad, Pakistan.
authors: Ghulam
authors: G
authors: Abbas
authors: Department of Pharmacy, Comsats Institute of Information Technology, Abbottabad, Pakistan.
authors: Wajahat
authors: W
authors: Mahmood
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D000069059:Atorvastatin; D018592:Cross-Over Studies; D064368:Healthy Volunteers; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010154:Pakistan; D011758:Pyrroles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets; D013810:Therapeutic Equivalency; D055815:Young Adult
chemical_list: D006538:Heptanoic Acids; D011758:Pyrroles; D013607:Tablets; D000069059:Atorvastatin