title: Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation.
abstract: Accelerated vascular smooth muscle cell (VSMC) proliferation is implied in cardiovascular disease and significantly contributes to vessel lumen reduction following surgical interventions such as percutaneous transluminal coronary angioplasty or bypass surgery. Therefore, identification and characterization of compounds and mechanisms able to counteract VSMC proliferation is of potential therapeutic relevance. This work reveals the anti-proliferative effect of the natural product capsaicin from Capsicum spp. by quantification of metabolic activity and DNA synthesis in activated VSMC. The observed in vitro activity profile of capsaicin warrants further research on its mechanism of action and potential for therapeutic application.
authors: Department of Pharmacognosy, University of Vienna, Vienna, Austria ; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors: Rongxia
authors: R
authors: Liu
authors: Department of Pharmacognosy, University of Vienna, Vienna, Austria.
authors: Elke H
authors: EH
authors: Heiss
authors: Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors: Dean
authors: D
authors: Guo
authors: Department of Pharmacognosy, University of Vienna, Vienna, Austria.
authors: Verena M
authors: VM
authors: Dirsch
authors: Department of Pharmacognosy, University of Vienna, Vienna, Austria.
authors: Atanas G
authors: AG
authors: Atanasov
keywords: Capsaicin; proliferation; restenosis; vascular smooth muscle cells