title: Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins.
abstract: BACKGROUND
  Statin intolerance is a medical condition often leading patients to nonadherence to the prescribed therapy or to a relevant reduction of the statin dosage. Both situations determine a totally or partially uncontrolled lipid profile, and these conditions unquestionably increase the risk of cardiovascular events.
  
  
  METHODS
  We enrolled hypercholesterolemic, type 2 diabetic patients complaining of intolerance to statins. Some of them had reduced the statin dose 'until the disappearance of symptoms'; others had opted for treatment with ezetimibe; and yet others were not undergoing any treatment at all. All patients of the three groups were then given a fixed combination of berberine and silymarin (Berberol(®)), known from previous papers to be able to control both lipidic and glycemic profiles.
  
  
  RESULTS
  The tested product both as a single therapy and as add-on therapy to low-dose statin or to ezetimibe reduced triglycerides, low-density lipoprotein cholesterol, fasting blood glucose, and glycosylated hemoglobin in a significant manner without inducing toxicity conditions that might be somehow ascribed to a statin-intolerant condition.
  
  
  CONCLUSIONS
  Our study demonstrates that use of Berberol(®), administered as a single or add-on therapy in statin-intolerant subjects affected by diabetes and hypercholesterolemia is a safe and effective tool capable of improving the patients' lipidic and glycemic profiles.
authors: Scientific Department, Velleja Research, Milan, Italy.
authors: Francesco
authors: F
authors: Di Pierro
authors: ASL TO1, Turin, Italy.
authors: Iaele
authors: I
authors: Bellone
authors: AIOR, Pontenure, Province of Piacenza, Italy.
authors: Giuliana
authors: G
authors: Rapacioli
authors: University Hospital San Gerardo, Monza, Italy.
authors: Pietro
authors: P
authors: Putignano
keywords: Berberol®; berberine; cholesterol; ezetimibe; silymarin; type 2 diabetes