title: Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production.
abstract: Three new canthinone type alkaloids, canthin-6-one-1-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (2) and canthin-6-one-1-O-[2-β-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells.
authors: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Hye Mi
authors: HM
authors: Kim
authors: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Su Jung
authors: SJ
authors: Kim
authors: Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Ha-Yeong
authors: HY
authors: Kim
authors: Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Byeol
authors: B
authors: Ryu
authors: Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Hokwang
authors: H
authors: Kwak
authors: Central Research Institute, Whan In Pharm Co., Ltd, Suwon 443-766, Republic of Korea.
authors: Jonghyun
authors: J
authors: Hur
authors: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Jung-Hye
authors: JH
authors: Choi
authors: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address: dsjang@khu.ac.kr.
authors: Dae Sik
authors: DS
authors: Jang
mesh_terms: D032268:Ailanthus / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D002243:Carbolines; D005960:Glucosides; D026121:Indole Alkaloids; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide; C453379:canthin-6-one
keywords: Ailanthus altissima; Canthinone type alkaloids; Inflammation; Nitric oxide; Simaroubaceae