title: Dog models for blinding inherited retinal dystrophies.
abstract: Spontaneous canine models exist for several inherited retinal dystrophies. This review will summarize the models and indicate where they have been used in translational gene therapy trials. The RPE65 gene therapy trials to treat childhood blindness are a good example of how studies in dogs have contributed to therapy development. Outcomes in human clinical trials are compared and contrasted with the result of the preclinical dog trials.
authors: 1 Department of Small Animal Clinical Sciences, Michigan State University , East Lansing, MI 48824.
authors: Simon M
authors: SM
authors: Petersen-Jones
authors: András M
authors: AM
authors: Komáromy
mesh_terms: D000818:Animals; D001766:Blindness / Q000235:genetics / Q000628:therapy*; D003117:Color Vision Defects / Q000235:genetics / Q000628:therapy; D004195:Disease Models, Animal; D004285:Dogs; D015316:Genetic Therapy; D006801:Humans; D057130:Leber Congenital Amaurosis / Q000235:genetics / Q000628:therapy; D008268:Macular Degeneration / Q000235:genetics / Q000628:therapy; D058499:Retinal Dystrophies / Q000235:genetics / Q000628:therapy*; D019745:cis-trans-Isomerases / Q000235:genetics; D000099178:Retinoid Isomerohydrolase
chemical_list: D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase