title: Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in localized prostate cancer.
abstract: Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer.
  
  
  METHODS
  We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across TCF7L2, and genotyped in 458 localized prostate cancer patients treated with radical prostatectomy (RP). Kaplan-Meier analysis, Cox proportional hazard model, and survival tree analyses were performed to identify significant SNPs that correlated with biochemical recurrence (BCR) after surgery.
  
  
  RESULTS
  A higher-order SNP-SNP interaction profile consisting of TCF7L2 rs7094463, rs10749127, and rs11196224 was significantly associated with BCR (P trend = 0.001). After adjusting for possible confounders, the genetic profile remained significant (P trend = 0.007). None of the studied SNPs were individually associated with BCR.
  
  
  CONCLUSIONS
  Our results support a genetic interaction in the TCF7L2 SNPs as a predictor of disease recurrence after curative RP in localized prostate cancer patients.
authors: 1. Department of Pharmacy, China Medical University, Taichung, Taiwan.
authors: Chien-Shu
authors: CS
authors: Chen
authors: 2. Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors: Chao-Yuan
authors: CY
authors: Huang
authors: 3. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan ; 4. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Shu-Pin
authors: SP
authors: Huang
authors: 5. Department of Urology, E-Da Hospital, Kaohsiung, Taiwan ; 6. School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
authors: Victor C
authors: VC
authors: Lin
authors: 7. Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan ; 8. Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan ; 9. Department of Pharmacy, Tajen University, Pingtung, Taiwan.
authors: Chia-Cheng
authors: CC
authors: Yu
authors: 10. Department of Occupational Safety and Health, China Medical University, Taichung, Taiwan.
authors: Ta-Yuan
authors: TY
authors: Chang
authors: 1. Department of Pharmacy, China Medical University, Taichung, Taiwan ; 11. Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan ; 12. Department of Nursing, Asia University, Taichung, Taiwan.
authors: Bo-Ying
authors: BY
authors: Bao
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D060449:Wnt Signaling Pathway
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: TCF7L2; Wnt pathway; biochemical recurrence; prostate cancer; radical prostatectomy; single-nucleotide polymorphism