title: Biocatalysis and biotransformation in Brazil: An overview.
abstract: This review presents the recent research in biocatalysis and biotransformation in Brazil. Several substrates were biotransformed by fungi, bacteria and plants. Biocatalytic deracemization of secondary alcohols, oxidation of sulfides, sp(3) CH hydroxylation and epoxidation of alkenes were described. Chemo-enzymatic resolution of racemic alcohols and amines were carried out with lipases using several substrates containing heteroatoms such as silicon, boron, selenium and tellurium. Biotransformation of nitriles by marine fungi, hydrolysis of epoxides by microorganisms of Brazilian origin and biooxidation of natural products were described. Enzymatic reactions under microwave irradiation, continuous flow, and enzymatic assays using fluorescent probes were reported.
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil.
authors: Willian G
authors: WG
authors: Birolli
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil.
authors: Irlon M
authors: IM
authors: Ferreira
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil.
authors: Natália
authors: N
authors: Alvarenga
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil.
authors: Darlisson de A
authors: Dde A
authors: Santos
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil.
authors: Iara L
authors: IL
authors: de Matos
authors: Instituto de Química, Departamento de Química Fundamental, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000 São Paulo, SP, Brazil; Instituto de Ciências Ambientais, Químicas e Farmacêuticas,Universidade Federal de São Paulo, Av. Prof. Artur Riedel, 275, 09972-270 Diadema, SP, Brazil. Electronic address: jvcomass@iq.usp.br.
authors: João V
authors: JV
authors: Comasseto
authors: Laboratório de Química Orgânica e Biocatálise, Instituto de Química de São Carlos, Universidade de São Paulo, Av. João Dagnone, 1100, J. Santa Angelina, 13563-120, São Carlos, SP, Brazil. Electronic address: almporto@iqsc.usp.br.
authors: André L M
authors: AL
authors: Porto
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D055162:Biocatalysis; D001709:Biotechnology / Q000379:methods*; D001711:Biotransformation; D001938:Brazil; D005658:Fungi / Q000378:metabolism*; D010084:Oxidation-Reduction
keywords: Biooxidation; Bioreduction; Brazilian microorganisms; Chemo-enzymatic resolution; Deracemization; Epoxidation; Lipases