title: The relative net health benefit of liver resection, ablation, and transplantation for early hepatocellular carcinoma.
abstract: BACKGROUND
  There are no conclusive cost-effectiveness studies measuring the efficacy of salvage LT after liver resection (LR) and radiofrequency ablation (RFA) in patients with early hepatocellular carcinoma (HCC) and compensated cirrhosis. The aim of the present study is to compare liver transplantation (LT) versus locoregional therapy plus salvage LT (to treat tumor recurrence) in patients with early HCC and compensated cirrhosis.
  
  
  METHODS
  Reference case: 55-year old male with HCC within Milan criteria and Child-Pugh A cirrhosis. The analysis was performed in two geographical cost settings: USA and Italy. Survival benefit measured in quality-adjusted life years (QALYs), costs (C) in US$, incremental cost-effectiveness, willingness to pay, and net health benefit (NHB).
  
  
  RESULTS
  In the base-case analysis, NHB of LT vs. LR and RFA was -1.7 and -1.3 years for single tumor ≤3 cm, -1.2 and -0.7 for single nodules measuring 3.1-5 cm and -0.7 and -0.7 for multi-nodular tumor ≤3 cm in Italy. In USA, NHB of LT versus LR and RFA were -1.2 and -0.8 years for single tumor ≤3 cm, -0.9 and -0.5 for single nodules measuring 3.1-5 cm, and -0.5 and -0.4 for multi-nodular tumor ≤ 3 cm. On the Monte Carlo simulation, only young patients with multi-nodular HCC and short waiting list time had a positive NHB. Salvage LT proved to be an ineffective cost strategy after RFA or LR.
  
  
  CONCLUSIONS
  In patients with HCC within Milan criteria and Child-Pugh A cirrhosis, LR and RFA were more cost-effective than LT. Salvage LT was not cost-effective.
authors: Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
authors: Gaya
authors: G
authors: Spolverato
authors: Alessandro
authors: A
authors: Vitale
authors: Aslam
authors: A
authors: Ejaz
authors: Yuhree
authors: Y
authors: Kim
authors: Shishir K
authors: SK
authors: Maithel
authors: David P
authors: DP
authors: Cosgrove
authors: Timothy M
authors: TM
authors: Pawlik
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000191:economics; D003362:Cost-Benefit Analysis; D006498:Hepatectomy / Q000191:economics; D006801:Humans; D007558:Italy; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000191:economics; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D019057:Quality-Adjusted Life Years; D016879:Salvage Therapy; D014481:United States; D014850:Waiting Lists