title: Patterns of presentation and thrombosis outcome in patients with polycythemia vera strictly defined by WHO-criteria and stratified by calendar period of diagnosis.
abstract: Most studies in polycythemia vera (PV) include patients with both remote and most recent diagnostic periods and are therefore vulnerable to inaccurate interpretation of time-dependent data. We addressed the particular issue by analyzing presenting characteristics and outcome data among 1,545 patients with WHO-defined PV stratified by a diagnosis period of before or after 2005, which coincides with the first description of JAK2V617F as the molecular marker of PV. Patients diagnosed after 2005 displayed lower hemoglobin values (P < 0.0001) and older age (P = 0.007) at diagnosis; we suggest ease of diagnosis offered by a molecular marker enabled earlier diagnosis and broader application across older age groups that is further enhanced by recent trends in increased attention and health monitoring for the elderly. Post-2005 diagnosed patients were also more or less likely to receive aspirin and cytoreductive therapy, respectively, and, despite their older age distribution, displayed significantly lower risk of thrombosis in high risk disease. Regardless of the contributing factors to the latter phenomenon, our observations underscore the need to reassess current demographics and frequencies of thrombosis in clinical trial designs including thrombosis prevention in PV.
authors: Research Foundation Papa Giovanni XXIII Hospital, Bergamo, Italy.
authors: Tiziano
authors: T
authors: Barbui
authors: Alessandro M
authors: AM
authors: Vannucchi
authors: Alessandra
authors: A
authors: Carobbio
authors: Jurgen
authors: J
authors: Thiele
authors: Elisa
authors: E
authors: Rumi
authors: Heinz
authors: H
authors: Gisslinger
authors: Francesco
authors: F
authors: Rodeghiero
authors: Maria Luigia
authors: ML
authors: Randi
authors: Alessandro
authors: A
authors: Rambaldi
authors: Lisa
authors: L
authors: Pieri
authors: Animesh
authors: A
authors: Pardanani
authors: Francesco
authors: F
authors: Passamonti
authors: Guido
authors: G
authors: Finazzi
authors: Ayalew
authors: A
authors: Tefferi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001317:Austria; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007391:International Cooperation; D007558:Italy; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013927:Thrombosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D000925:Anticoagulants; D001241:Aspirin; D006918:Hydroxyurea