title: A huge nodular fasciitis in parapharygneal space in a 7-year-old girl: a case report and review of literature.
abstract: Nodular fasciitis (NF) is a benign and reactive fibroblastic growth extending from the superficial fascia into the subcutaneous tissue or muscle, with a morbidity of less than 20% in children. We report a case of a 7-year-old girl presented with a 3-month history of snore and mouth breathing. Image findings demonstrated a large soft-tissue mass in the right parapharyngeal space. The lesion was successfully eradicated by surgical removal. Pathological analysis established NF as the final diagnosis. Histopathological findings were notable for a reactive spindle-cell process composed of proliferative fibroblasts with extravasated red blood cells and interstitial edema. Immunohistochemical stains showed that the lesional cells were positive for smooth muscle actin (SMA), muscle-specific actin (HHF35), and epithelial membrane antigen (EMA), and negative for S100 protein. No clinical evidence of recurrence was noticed after 2 months of follow-up. Being the first report of NF in the parapharyngeal space of a child, this rare pediatric case points out the importance for otolaryngologists to keep NF in mind for differential diagnosis to avoid unnecessary wide resection.
authors: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University Changsha, P.R. China.
authors: Shumin
authors: S
authors: Xie
authors: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University Changsha, P.R. China.
authors: Wei
authors: W
authors: Liu
authors: Department of Human Anatomy, University of South China Hengyang, P.R. China.
authors: Yuyan
authors: Y
authors: Xiang
authors: Department of Pathology, The Second Xiangya Hospital of Central South University P.R. China.
authors: Yinghuan
authors: Y
authors: Dai
authors: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University Changsha, P.R. China.
authors: Jihao
authors: J
authors: Ren
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002648:Child; D005208:Fasciitis / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009058:Mouth Breathing / Q000209:etiology; D010608:Pharyngeal Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010614:Pharynx / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012913:Snoring / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Nodular fasciitis; children; parapharygneal space; solitary fibrous tumor