title: Titanium implants with modified surfaces: meta-analysis of in vivo osteointegration.
abstract: Titanium-based implants are widely used in modern clinical practice, but their "optimal" properties in terms of porosity and topology, roughness and hydrophilic parameters are being a subject of intensive discussions. Recent in vitro results have shown a possibility to optimize the surface of an implant with maximal repelling of bacteria (Staphylococcus aureus, Staphylococcus epidermidis) and improvement in human osteogenic and endothelial cell adhesion, proliferation and differentiation. In this work, these different grades titanium implants were tested in vivo using the same analytical methodology. In addition to material parameters, key histomorphometrical parameters such a regeneration area, bone adaptation area and bone-to-implant contact were determined after 2 and 4weeks of implantation in rabbit animal model. Porous implants have more clear differences than non-porous ones, with the best optimum values obtained on hydrothermally treated electrophoretically deposited titanium. These in vivo data correlate well with the optimal prediction made by in vitro tests.
authors: Aalto University Foundation, School of Chemical Technology, P.O. Box 16200, FIN-00076 AALTO, Finland. Electronic address: michael.gasik@aalto.fi.
authors: Michael
authors: M
authors: Gasik
authors: Department of Metallurgy and Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, B-3001 Heverlee, Belgium.
authors: Annabel
authors: A
authors: Braem
authors: Department of Prosthetic Dentistry, BIOMAT Research Cluster, KU Leuven, Kapucijnenvoer 7a, B-3000 Leuven, Belgium.
authors: Amol
authors: A
authors: Chaudhari
authors: Department of Prosthetic Dentistry, BIOMAT Research Cluster, KU Leuven, Kapucijnenvoer 7a, B-3000 Leuven, Belgium.
authors: Joke
authors: J
authors: Duyck
authors: Department of Metallurgy and Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, B-3001 Heverlee, Belgium.
authors: Jozef
authors: J
authors: Vleugels
mesh_terms: D000818:Animals; D004343:Drug Implants; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium / Q000008:administration & dosage*
chemical_list: D004343:Drug Implants; D014025:Titanium
keywords: Bone; Data analysis; Histomorphometry; Osteointegration; Surface; Titanium