title: Nuclear and cellular plasticity: nuclear RAC1 takes center stage.
abstract: Navarro-Lérida et al. (2015) report in this issue of Developmental Cell that RAC1 nuclear accumulation causes actin-dependent deformation of the nuclear envelope and increases nuclear plasticity. It further leads to depletion of cytoplasmic, active RAC1 with a concomitant increase in RHOA signaling driving actomyosin-mediated cell shape changes. These two properties combine to enhance tumor cells invasiveness.
authors: IFOM (FIRC Institute for Molecular Oncology), 20139 Milan, Italy.
authors: Andrea
authors: A
authors: Disanza
authors: IFOM (FIRC Institute for Molecular Oncology), 20139 Milan, Italy; Dipartimento di Science della Salute, Università degli Studi di Milano, 20142 Milan, Italy. Electronic address: giorgio.scita@ifom.eu.
authors: Giorgio
authors: G
authors: Scita
mesh_terms: D000199:Actins / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D006801:Humans
chemical_list: D000199:Actins