title: The use of antioxidative stress enzymes, lipid peroxidation, and red blood cell abnormalities as biomarkers of stress in Periphthalmus papilio of the polluted coastal Lagos lagoon.
abstract: We assessed the mudskipper, Periphthalmus papilio inhabiting the coast line of the Lagos lagoon, Gulf of Guinea, to determine suitable biomarkers of stress due to its current status as a polluted water body. The gill and liver samples showed evidence of some activities of antioxidative stress enzymes including catalase, superoxide dismutase, glutathione-s-transferase, reduced glutahthione, as well as some detectable levels of lipid peroxidation product. The stress status of the fishes was also elucidated by nuclear abnormalities especially micronucleus formation and the presence of numerous vacuolated red blood cells. Given the current need for more sensitive bioindicators in monitoring pollution in this lagoon, we hereby present these inherent responses in P. papilio as a suitable candidate for incorporation into the current repertoire for ecotoxicological investigations in polluted water bodies of the Gulf of Guinea coastline.
authors: Ecotoxicology and Conservation Unit, Ecotoxicology Laboratory, Department of Zoology, University of Lagos, Akoka-Yaba, Lagos, Nigeria, amaezenh@gmail.com.
authors: Amaeze H
authors: AH
authors: Nnamdi
authors: Adebesin A
authors: AA
authors: Olumide
authors: Adepegba E
authors: AE
authors: Adeladun
authors: Kolapo
authors: K
authors: Oyenike
authors: Egonmwan I
authors: EI
authors: Rosemary
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004784:Environmental Monitoring / Q000379:methods*; D004912:Erythrocytes / Q000378:metabolism; D005880:Gills / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D009549:Nigeria; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*; D014876:Water Pollution
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase