title: Frontal delta event-related oscillations relate to frontal volume in mild cognitive impairment and healthy controls.
abstract: Amnesic mild cognitive impairment (MCI) represents a risk of developing Alzheimer's disease (AD), but not all MCI subjects progress to dementia of AD type. Magnetic resonance imaging (MRI) of cortical and hippocampal atrophy supports early diagnosis of AD in MCI subjects, while frontal event-related oscillations (EROs) at delta frequencies (<4Hz) are appealing markers for this purpose, as they are both cost-effective and largely available. The present study tested the hypothesis that these EROs reflect cortical frontal neurodegeneration in the continuum between normal and amnesic MCI subjects. EROs and volumetric MRI data were recorded in 28 amnesic MCI and in 28 healthy elderly controls (HCs). EROs were collected during a standard visual oddball paradigm including frequent (66.6%) and rare (33.3%; targets to be mentally counted) stimuli. Peak-to-peak amplitude of delta target EROs (<4Hz) was measured. Volume of frontal cortex was estimated from MRIs. Frontal volume was lower in MCI compared to the HC group. Furthermore, widespread delta target EROs were lower in amplitude in the former than in the latter group. Finally, there was a positive correlation between frontal volume and frontal delta target EROs in MCI and HC subjects as a whole group. These results suggest that frontal delta EROs reflect frontal neurodegeneration in the continuum between normal and amnesic MCI subjects.
authors: Department of Neurology, Dokuz Eylül University Medical School, Izmir 35340, Turkey; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir 35340, Turkey; Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey. Electronic address: gorsev.yener@deu.edu.tr.
authors: Görsev G
authors: GG
authors: Yener
authors: Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey; Department of Psychology, Dokuz Eylül University, Izmir 35160, Turkey.
authors: Derya Durusu
authors: DD
authors: Emek-Savaş
authors: IRCCS San Raffaele Pisana, Roma, Italy.
authors: Roberta
authors: R
authors: Lizio
authors: Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey.
authors: Berrin
authors: B
authors: Çavuşoğlu
authors: Laboratory of Neuroimaging, Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
authors: Filippo
authors: F
authors: Carducci
authors: Department of Radiology, Dokuz Eylül University Medical School, Izmir 35340, Turkey.
authors: Emel
authors: E
authors: Ada
authors: Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey.
authors: Bahar
authors: B
authors: Güntekin
authors: IRCCS San Raffaele Pisana, Roma, Italy; Laboratory of High resolution EEG, Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
authors: Claudio C
authors: CC
authors: Babiloni
authors: Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey.
authors: Erol
authors: E
authors: Başar
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000473:pathology*; D003700:Delta Rhythm / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Alzheimer; Delta; Dementia; EEG; Event-related; Frontal; MCI; MRI; Oscillations; Volumetry