title: Toward a new twist in Hox and TALE DNA-binding specificity.
abstract: Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gene expression in vivo.
authors: Institut de Génomique Fonctionnelle de Lyon (IGFL), UMR5242, ENS Lyon, 46 Allée d'Italie, 69007 Lyon, France. Electronic address: samir.merabet@ens-lyon.fr.
authors: Samir
authors: S
authors: Merabet
authors: Department of Developmental Biology, Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, D-69120 Heidelberg, Germany. Electronic address: ingrid.lohmann@bioquant.uni-heidelberg.de.
authors: Ingrid
authors: I
authors: Lohmann
mesh_terms: D000818:Animals; D001934:Branchial Region / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D004742:Enhancer Elements, Genetic; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C489833:Hoxa2 protein, mouse; D014157:Transcription Factors