title: Health-promoting effects of the citrus flavanone hesperidin.
abstract: Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large amounts from the rinds of some citrus species. Considering the wide range of pharmacological activities and widespread application of hesperidin, this paper reviews preclinical and clinical trials of hesperidin and its related compounds, including their occurrence, pharmacokinetics, and some marketed products available. Preclinical studies and clinical trials demonstrated therapeutical effects of hesperidin and its aglycone hesperetin in various diseases, such as neurological disorders, psychiatric disorders, and cardiovascular diseases and others, due to its anti-inflammatory, antioxidant, lipid-lowering, and insulin-sensitizing properties.
authors: a Division of Immunopathology of the Nervous System , Department of Neuropathology , Institute of Pathology and Neuropathology, University of Tuebingen , Tuebingen , Germany.
authors: Chaoyun
authors: C
authors: Li
authors: a Division of Immunopathology of the Nervous System , Department of Neuropathology , Institute of Pathology and Neuropathology, University of Tuebingen , Tuebingen , Germany.
authors: Hermann
authors: H
authors: Schluesener
mesh_terms: D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000975:Antioxidants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002957:Citrus / Q000737:chemistry*; D004338:Drug Combinations; D006569:Hesperidin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004338:Drug Combinations; D006569:Hesperidin; C013015:hesperetin
keywords: Hesperidin; hesperitin; pharmacokinetics; pharmacology