title: Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study.
abstract: Genetic variants of whole mitochondrial DNA (mtDNA) that predispose to exceptional longevity need to be systematically identified and appraised. Here, we conducted a case-control study with 237 exceptional longevity subjects (aged 95-107) and 444 control subjects (aged 40-69) randomly recruited from a "longevity town"-the city of Rugao in China-to investigate the effects of mtDNA variants on exceptional longevity. We sequenced the entire mtDNA genomes of the 681 subjects using a next-generation platform and employed a complete mtDNA phylogenetic analytical strategy. We identified T3394C as a candidate that counteracts longevity, and we observed a higher load of private nonsynonymous mutations in the COX1 gene predisposing to female longevity. Additionally, for the first time, we identified several variants and new subhaplogroups related to exceptional longevity. Our results provide new clues for genetic mechanisms of longevity and shed light on strategies for evaluating rare mitochondrial variants that underlie complex traits.
authors: State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Songhu Rd., Shanghai, 200433, China.
authors: Lei
authors: L
authors: Li
authors: Hong-Xiang
authors: HX
authors: Zheng
authors: Zuyun
authors: Z
authors: Liu
authors: Zhendong
authors: Z
authors: Qin
authors: Fei
authors: F
authors: Chen
authors: Degui
authors: D
authors: Qian
authors: Jun
authors: J
authors: Xu
authors: Li
authors: L
authors: Jin
authors: Xiaofeng
authors: X
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D054629:Genome, Mitochondrial / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D004272:DNA, Mitochondrial