title: The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.
abstract: The aim of this study was to evaluate the diagnostic value of the serum biochemical markers high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD) and fibrinogen (Fg) in differentiating etiological subtypes of ischemic stroke. This study was a retrospective case-only study, consecutively including patients with acute ischemic stroke. All patients were classified into subtypes using the TOAST classification system. A total of 317 patients were evaluated. Hs-CRP and DD levels were significantly different among the subtypes and were the highest in CE, followed by LAA and SAA; no significant difference between the subtypes was found for Fg. Hs-CRP > 6.96 mg/L was classified as the CE subtype, with a sensitivity of 41% and a specificity of 74%; DD > 791.30 ng/mL was classified as CE, with a sensitivity of 58% and a specificity of 78%. The combination of hs-CRP and DD classification as CE yielded a sensitivity of 65% and a specificity of 91%. DD > 791.30 ng/mL was considered an independent predictive factor of CE. Hs-CRP and DD could be useful for identifying the etiological subtypes of acute ischemic stroke, especially for predicting CE. The diagnostic value of DD was higher than that of hs-CRP.
authors: Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Neurology, Zhuhai Hospital of Jinan University, Zhuhai, China.
authors: Li-Bin
authors: LB
authors: Liu
authors: Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
authors: Mu
authors: M
authors: Li
authors: Department of Neurology, Zhuhai Hospital of Jinan University, Zhuhai, China.
authors: Wen-Yan
authors: WY
authors: Zhuo
authors: Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
authors: Yu-Sheng
authors: YS
authors: Zhang
authors: Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
authors: An-Ding
authors: AD
authors: Xu
mesh_terms: D000368:Aged; D015415:Biomarkers; D002545:Brain Ischemia / Q000150:complications*; D002097:C-Reactive Protein; D003937:Diagnosis, Differential; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen; D002097:C-Reactive Protein