title: Clinical presentation and pathophysiology of gastroparesis.
abstract: Gastroparesis is a heterogeneous disorder defined by delay in gastric emptying. Symptoms of gastroparesis are nonspecific, including nausea, vomiting, early satiety, bloating, and/or abdominal pain. Normal gastric motor function and sensory function depend on a complex coordination between the enteric and central nervous system. This article discusses the pathophysiology of delayed gastric emptying and the symptoms of gastroparesis, including antropyloroduodenal dysmotility, impaired gastric accommodation, visceral hypersensitivity, and autonomic dysfunction. The underlying pathophysiology of gastroparesis is complex and multifactorial. The article discusses how a combination of these factors leads to symptoms of gastroparesis.
authors: Division of Gastroenterology, Department of Medicine, Stanford University, 900 Blake Wilbur Drive, 2nd Floor, Palo Alto, CA 94305, USA. Electronic address: nguyenLB@stanford.edu.
authors: Linda Anh
authors: LA
authors: Nguyen
authors: Division of Gastroenterology, Department of Medicine, California Pacific Medical Center, 2340 Clay Street, Suite 210, San Francisco, CA 94115, USA. Electronic address: snapew@sutterhealth.org.
authors: William J
authors: WJ
authors: Snape
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D004415:Dyspepsia / Q000209:etiology; D005746:Gastric Emptying / Q000502:physiology; D018589:Gastroparesis / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D009325:Nausea / Q000209:etiology; D012720:Severity of Illness Index; D014839:Vomiting / Q000209:etiology
keywords: Gastric accommodation; Gastric emptying; Gastric motor function; Gastroparesis; Pathophysiology; Visceral hypersensitivity