title: Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report.
abstract: Cellular angiofibroma (CAF) is a rare soft tissue tumor characterized by random arrangement of spindle tumor cells in the stroma with short collagen bundles and thick- and hyalinized small vessels. CAFs share histological characteristics with spindle cell lipomas and mammary type myofibroblastomas. Because these tumors harbor monoallelic 13q14, common genetic and molecular mechanism for tumorigenesis is presumed. In this study, we reported a case of CAF in a 69-year-old man with monoallelic 13q14. Immunohistochemical analysis revealed that FOXO1, which is located in chromosome 13q14, was not expressed in the tumor. We also detected oxidative stress markers and found p38 MAPK activation, which is often induced by cellular stressors such as reactive oxygen species (ROS). Because FOXO1 induces the expression of genes encoding enzymes that generate antioxidants, oxidative stress induced by loss of FOXO1 expression may be common among CAFs, spindle cell lipomas, and mammary type myofibroblastomas.
authors: Department of Pathology and Cell Biology, Graduate School of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Kazunari
authors: K
authors: Arakaki
authors: Department of Pathology, Nerima General Hospital Tokyo, Japan.
authors: Katsuya
authors: K
authors: Chinen
authors: Pathological Cytology Section, Hamura Laboratory, SRL, Inc Tokyo, Japan.
authors: Masuzo
authors: M
authors: Kamiya
authors: Department of Basic Laboratory Sciences, Division of Morphological Pathology, School of Health Sciences, Faculty of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Yasuka
authors: Y
authors: Tanabe
authors: Department of Basic Laboratory Sciences, Division of Morphological Pathology, School of Health Sciences, Faculty of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Natsumi
authors: N
authors: Tawata
authors: Department of Basic Laboratory Sciences, Division of Morphological Pathology, School of Health Sciences, Faculty of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Fukino
authors: F
authors: Ikehara
authors: Department of Basic Laboratory Sciences, Division of Morphological Pathology, School of Health Sciences, Faculty of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Karina
authors: K
authors: Uehara
authors: Department of Urology, Tomishiro Chuo Hospital Okinawa, Japan.
authors: Hiroichi
authors: H
authors: Shimabukuro
authors: Department of Basic Laboratory Sciences, Division of Morphological Pathology, School of Health Sciences, Faculty of Medicine, University of The Ryukyus Okinawa, Japan.
authors: Takao
authors: T
authors: Kinjo
mesh_terms: D000368:Aged; D018322:Angiofibroma / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000032:analysis; D063646:Carcinogenesis; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D012611:Scrotum / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors
keywords: Cellular angiofibroma; FOXO1; RB1; ROS; monoallelic deletion; p38 MAPK