title: [Gravidaprotective action of phenibut in experimental pre-eclampsia].
abstract: It was established that the replacement of drinking water by 1.8% NaCl solution in female rats during pregnancy causes experimental pre-eclampsia (EP), as evidenced by an increase in the blood pressure, proteinuria, and edema in the control group as compared to pregnant female rats with normal drinking regime. Animals with EP exhibited disturbance of vasodilating endothelial function, microcirculation disorder, and increased coagulation and thrombogenic potential of blood. In addition, the group with EP showed evidence of the activation of lipid peroxidation (LPO) due to lower activity of antioxidant enzymes. Daily oral administration ofphenibut (25 mg/kg) in female rats with EP during pregnancy prevents the increase in blood pressure and the severity of proteinuria and edemation. Phenibut improves the vasodilator and antithrombotic endothelial functions, increases uterine blood flow, improves microcirculation, limits LPO, and increases the activity of antioxidant enzymes.
authors: I N
authors: IN
authors: Tiurenkov
authors: V N
authors: VN
authors: Perfilova
authors: V I
authors: VI
authors: Karamysheva
authors: T A
authors: TA
authors: Popova
authors: S A
authors: SA
authors: Lebedeva
authors: L I
authors: LI
authors: Mikhaĭlova
authors: G A
authors: GA
authors: Zhakupova
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D010920:Placenta / Q000098:blood supply / Q000187:drug effects; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats; D012965:Sodium Chloride; D014599:Uterus / Q000098:blood supply / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D012965:Sodium Chloride; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid