title: Surface characterization and cytotoxicity response of biodegradable magnesium alloys.
abstract: Magnesium alloys have raised an immense amount of interest to many researchers because of their evolution as a new kind of third generation materials. Due to their biocompatibility, density, and mechanical properties, magnesium alloys are frequently reported as prospective biodegradable implant materials. Moreover, magnesium alloys experience a natural phenomenon to biodegrade in aqueous solutions due to its corrosion activity, which is excellent for orthopedic and cardiovascular applications. However, a major concern with such alloys is fast and non-uniform corrosion degradation. Controlling the degradation rate in the physiological environment determines the success of biodegradable implants. In this investigation, three different grades of magnesium alloys: AZ31B, AZ91E and ZK60A were studied for their corrosion resistance and biocompatibility. Scanning electron microscopy, energy dispersive spectroscopy, atomic force microscopy and contact angle meter are used to study surface morphology, chemistry, roughness and wettability, respectively. Additionally, the cytotoxicity of the leached metal ions was evaluated by using a tetrazolium based bio-assay, MTS.
authors: Mechanical Engineering Department, University of Texas Pan American, Edinburg, TX, United States.
authors: Luis
authors: L
authors: Pompa
authors: Mechanical Engineering Department, University of Texas Pan American, Edinburg, TX, United States.
authors: Zia Ur
authors: ZU
authors: Rahman
authors: Mechanical Engineering Department, University of Texas Pan American, Edinburg, TX, United States.
authors: Edgar
authors: E
authors: Munoz
authors: Mechanical Engineering Department, University of Texas Pan American, Edinburg, TX, United States. Electronic address: haiderw@utpa.edu.
authors: Waseem
authors: W
authors: Haider
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D003343:Corrosion; D007477:Ions / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods; D018625:Microscopy, Atomic Force / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D013499:Surface Properties; D017155:Wettability
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D007477:Ions; D008274:Magnesium
keywords: Biodegradable; Corrosion; Cytotoxicity; Magnesium; Surface treatment