title: Efficacy of dexamethasone intravitreal implant for the treatment of diabetic macular edema.
abstract: OBJECTIVE
  To assess the efficacy of a single dexamethasone intravitreal implant (Dex-I) injection for the treatment of diabetic macular edema (DME).
  
  
  METHODS
  This was a retrospective chart review of 39 eyes (34 consecutive patients). Best-corrected visual acuity (BCVA), central macular thickness (CMT), and increase in intraocular pressure (IOP) (gt;24 mm Hg) were analyzed before treatment and 2 and 4 months after injection.
  
  
  RESULTS
  Preoperative mean CMT was 559 ± 111 μm and decreased to 338 ± 84 and 477 ± 140 μm 2 and 4 months after injection, respectively. Although all eyes showed a significant decrease in CMT 2 months after injection (p&lt;0.0001), a recurrence of the macular edema was observed 4 months after injection in 79% of eyes. Mean BCVA improvement (logMAR) was 0.13 ± 0.18 (p&lt;0.0001) and 0.07 ± 0.21 (p = 0.049) 2 and 4 months after injection, respectively, without significant difference between vitrectomized and nonvitrectomized eyes. Eight eyes (21%) developed reversible increase in IOP 2 months after injection.
  
  
  CONCLUSIONS
  Thirty percent of DME eyes had gained more than 2 logMAR lines 2 months after Dex-I injection and safety was good. Visual acuity gain was maintained 4 months after injection despite a recurrence of edema in most cases.
authors: Ophthalmology Department, Lariboisiere Hospital, Paris - France.
authors: Sophie
authors: S
authors: Bonnin
authors: Bénédicte
authors: B
authors: Dupas
authors: Mohamed El
authors: ME
authors: Sanharawi
authors: Julien
authors: J
authors: Perol
authors: Ali
authors: A
authors: Erginay
authors: Ramin
authors: R
authors: Tadayoni
authors: Pascale
authors: P
authors: Massin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology; D014822:Vitreous Body / Q000187:drug effects
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone