title: Moderate dietary supplementation with vitamin E enhances lymphocyte functionality in the adult cat.
abstract: This study aimed to determine the effects of supplemental Vit E and/or Se on selected parameters of the immune system of the cat. Nine diets were fed in a 3 × 3 factorial design with no supplementation (control (C)); and either moderate (M); or high (H) levels of Vit E (0, 225 or 450 mg/kg DM diet) and/or Se (0, 2 or 10 mg/kg DM diet) added to a complete and balanced basal diet. After 28 days of feeding, enhanced lymphocyte proliferative responses to Concanavalin A and phytohaemagglutinin were observed (P < 0.05) in cats fed diets containing supplemental Vit E, irrespective of whether they also contained Se. Cats in the MVitE, HVitE, MVitE + MSe, HVitE + MSe, and HVitE + HSe groups all showed enhancement of phagocytic activity compared to control animals (P < 0.001). Our results indicate that a supplemental level of 225 mg/kg DM diet Vit E appears to have beneficial effects on immune function in the cat.
authors: Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
authors: Teresa
authors: T
authors: O'Brien
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: David G
authors: DG
authors: Thomas
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: Patrick C H
authors: PC
authors: Morel
authors: Institute of Food, Nutrition and Human Health, Massey University, Albany, New Zealand. Electronic address: K.J.Rutherfurd@massey.ac.nz.
authors: Kay J
authors: KJ
authors: Rutherfurd-Markwick
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002415:Cats / Q000276:immunology*; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D007107:Immune System / Q000187:drug effects / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D012643:Selenium / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D012643:Selenium
keywords: Cat; Dietary supplementation; Feline; Immune function; Selenium; Vitamin E