title: Binary DNA hairpin-based colorimetric biochip for simultaneous detection of Pb(2+) and Hg(2+) in real-world samples.
abstract: A microarray-format colorimetric biochip was constructed on plastic using two specially-designed DNA hairpin strands as binary probes and a binding-induced conformational switching strategy as the signal generation protocol. Coupled with single- or dual-color staining, we were able to simultaneously detect and quantitate the trace amounts of Pb(2+) and Hg(2+) in various real-world samples.
authors: Department of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. liyc@bnu.edu.cn.
authors: Xiaoli
authors: X
authors: Shi
authors: Xiaoyi
authors: X
authors: Gao
authors: Lingling
authors: L
authors: Zhang
authors: Yunchao
authors: Y
authors: Li
authors: Louzhen
authors: L
authors: Fan
authors: Hua-Zhong
authors: HZ
authors: Yu
mesh_terms: D003116:Color; D003124:Colorimetry / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D055029:Inverted Repeat Sequences; D007854:Lead / Q000032:analysis*; D008628:Mercury / Q000032:analysis*; D046208:Microchip Analytical Procedures / Q000379:methods*; D013997:Time Factors
chemical_list: D007854:Lead; D004247:DNA; D008628:Mercury