title: Pd-catalyzed enantiodivergent and regiospecific phospha-Michael addition of diphenylphosphine to 4-oxo-enamides: efficient access to chiral phosphinocarboxamides and their analogues.
abstract: The palladacycle-catalyzed asymmetric P-H addition of 4-oxo-enamides has been developed, which provides efficient access to phosphinocarboxamides and their analogues. Solvent-mediated reversal of stereoselectivity (ee from +96% to -92%) was observed, and the underlying mechanism that allows facile access to both enantiomers of the product by judicious choice of solvents is revealed.
authors: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore (Singapore).
authors: Renta Jonathan
authors: RJ
authors: Chew
authors: Xi-Rui
authors: XR
authors: Li
authors: Yongxin
authors: Y
authors: Li
authors: Sumod A
authors: SA
authors: Pullarkat
authors: Pak-Hing
authors: PH
authors: Leung
keywords: asymmetric catalysis; enantiodivergence; hydrophosphination; palladium; phosphine ligands