title: [Roles of miR-15b in endothelial cell function and their relevance to vascular diseases].
abstract: MicroRNAs (miRNAs) are noncoding RNAs with a short length of about 22 nucleotides. As major modulators participating in RNA interference, they affect cellular behaviors by regulating the expression of diverse genes at post-transcriptional levels. miR-15b is a member of the miR-15/16 family, which is broadly expressed in major tissues and specially enriched in the endovascular system of human beings. miR-15/16 affects cellular proliferation, apoptosis, invasion and angiogenesis. In this review, we summarize the role and the underlying mechanism of miR-15b as well as other miR-15/16 family members in different cells, especially in endothelial cells. We focus on the diverse roles of miR-15b in the occurrence, progression and prognosis of vascular diseases, with particular emphasis on preeclampsia, a hypertensive disorder related to endovascular dysfunction in the placenta.
authors: Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors: Liang-Ju
authors: LJ
authors: Chen
authors: Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors: Ming
authors: M
authors: Yang
authors: Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors: Yan
authors: Y
authors: Chen
authors: Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors: Hua-Qin
authors: HQ
authors: Sun
authors: 1.Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China.|2.Department of Obstetric & Gynecologic Disease, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors: Wen-Ming
authors: WM
authors: Xu
mesh_terms: D000818:Animals; D019938:Cyclin D1 / Q000235:genetics; D019927:Cyclin E / Q000235:genetics; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D039943:Neuropilin-2 / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D014652:Vascular Diseases / Q000209:etiology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics
chemical_list: D019927:Cyclin E; C505361:MIRN15 microRNA, human; D035683:MicroRNAs; D039943:Neuropilin-2; D019253:Proto-Oncogene Proteins c-bcl-2; D019938:Cyclin D1; D040301:Vascular Endothelial Growth Factor Receptor-2