title: Percutaneous absorption of methimazole: an in vitro study of the absorption pharmacokinetics for two different vehicles.
abstract: The use of transdermal medications in cats has become popular in veterinary medicine due to the ease of administration compared to oral medication. However, the research to support systemic absorption of drugs applied to the pinna after transdermal administration in cats is limited. The aim of this study was to characterize the percutaneous absorption pharmacokinetics of methimazole in a lipophilic vehicle compared to methimazole in Pluronic(®) lecithin organogel (PLO) using a finite dose applied to feline ear skin in an in vitro Franz cell model. The two formulations of methimazole (10 mg) were applied to the inner stratum corneum of six pairs of feline ears. The receptor medium was sampled up to 30 h post-administration, and methimazole concentrations were measured using high-performance liquid chromatography (HPLC). Histological examination of all ears was undertaken as small differences in the thickness of ear skin may have contributed to inter-individual differences in methimazole absorption between six cats. Methimazole was absorbed more completely across the pinnal skin when administered in the lipophilic vehicle compared to administration in the PLO gel (P < 0.001).
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: K E
authors: KE
authors: Hill
authors: School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia.
authors: P C
authors: PC
authors: Mills
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: B R
authors: BR
authors: Jones
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: C F
authors: CF
authors: Bolwell
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: D
authors: D
authors: Aberdein
authors: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
authors: J P
authors: JP
authors: Chambers
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002415:Cats; D004431:Ear, External; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008713:Methimazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism*
chemical_list: D013956:Antithyroid Agents; D014677:Pharmaceutical Vehicles; D008713:Methimazole