title: New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients.
abstract: Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
authors: Koc University, School of Medicine, Department of Neurosurgery, Rumelifeneri Yolu, Sariyer 34450, Istanbul, Turkey. isolaroglu@ku.edu.tr.
authors: Ihsan
authors: I
authors: Solaroglu
authors: Murat
authors: M
authors: Digicaylioglu
authors: G Evren
authors: GE
authors: Keles
authors: John H
authors: JH
authors: Zhang
mesh_terms: D000818:Animals; D016179:Granulocyte Colony-Stimulating Factor / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D015398:Signal Transduction; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D016179:Granulocyte Colony-Stimulating Factor