title: Evaluation of anti-inflammatory, analgesic, and antipyretic activities of the ethanol extract from Murdannia loriformis (Hassk.) Rolla Rao et Kammathy.
abstract: BACKGROUND
  Murdannia loriformis (hassk) Rolla Roa et Kammathy, family Commelinaceae, is used by Chinese practitioners as a remedy for cancer in an early stage, and also for treating other diseases including colds, throat infections, pneumonia, diabetes mellitus, flu and inflammation. Although anticancer as well as other pharmacological effects of M. loriformis have been reported, its anti-inflammatory and other activities related to inflammation are still limited.
  
  
  METHODS
  The anti-inflammatory activity was evaluated using carrageenan- and arachidonic acid-induced paw edema in rats, and cotton pellet-induced granuloma formation in rats. The analgesic and antipyretic activities were determined by formalin test in mice and yeast-induced hyperthermia in rats, respectively.
  
  
  RESULTS
  The ethanol extract of the aerial part of M. loriformis exhibited anti-inflammatory activity on the rat paw edema induced by carrageenan and arachidonic acid. It also showed an inhibitory effect on the granuloma and the transudative formation of the rat implanted with cotton pellets as well as lowered the elevated serum alkaline phosphatase activity to normal level. It exerted potent analgesic effect on both the early and late phase of formalin test as well as the antipyretic effect on yeast-induced hyperthermic rats. The oral single high dose of the extract of 5,000 mg/Kg did not produce death or any abnormalities or changes of the internal organs of rats during 14 days of the observed period.
  
  
  CONCLUSIONS
  The results obtained from this study support the use of the plant in traditional medicine for inflammatory ailments.
authors: Department of Pharmacology and Center for Innovation in Chemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand ; Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors: Phraepakaporn
authors: P
authors: Kunnaja
authors: Department of Pharmacology and Center for Innovation in Chemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Somsakul Pop
authors: SP
authors: Wongpalee
authors: Department of Pharmacology and Center for Innovation in Chemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors: Ampai
authors: A
authors: Panthong
keywords: Acute toxicity; Analgesic and antipyretic activities; Anti-inflammatory activity; In vivo study; Murdannia loriformis