title: Controlled Drug Release from Pharmaceutical Nanocarriers.
abstract: Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique challenges in controlling drug release kinetics, due to the large surface area per volume ratio and the short diffusion distance. To develop nanocarriers with desirable release kinetics for target applications, it is important to understand the mechanisms by which a carrier retains and releases a drug, the effects of composition and morphology of the carrier on the drug release kinetics, and current techniques for preparation and modification of nanocarriers. This review provides an overview of drug release mechanisms and various nanocarriers with a specific emphasis on approaches to control the drug release kinetics.
authors: College of Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors: Jinhyun Hannah
authors: JH
authors: Lee
authors: College of Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA ; Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors: Yoon
authors: Y
authors: Yeo
keywords: Nanocarriers; controlled release; drug delivery; drug release kinetics; drug release mechanisms