title: Overexpression of LIMK1 promotes tumor growth and metastasis in gastric cancer.
abstract: Gastric cancer is the second-leading cause of cancer death in Asia. Despite improvement of therapies, the outcome in patients remains extremely poor because of metastasis. In the present study, we found that LIMK1 is overexpressed in gastric cancer, and its expression level correlate with tumor size, lymph node metastasis and TNM stage. Knockdown of LIMK1 expression could inhibit cell proliferation, migration and invasion in vitro, as well as suppress the activation of FAK/paxillin pathway. Moreover, knockdown of LIMK1 expression retarded tumor growth and peritoneal ametastasis in vivo. This highlights that LIMK1 might be used as a potential target in the treatment of gastric cancer.
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Tiangeng
authors: T
authors: You
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Wei
authors: W
authors: Gao
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Jun
authors: J
authors: Wei
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Xiaoli
authors: X
authors: Jin
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Zhongxin
authors: Z
authors: Zhao
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China.
authors: Congjun
authors: C
authors: Wang
authors: Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, NO. 150 Jimo Rd., Shanghai 200120, People's Republic of China. Electronic address: namekuji@163.com.
authors: Yang
authors: Y
authors: Li
mesh_terms: D000368:Aged; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D054461:Lim Kinases / Q000378:metabolism*; D008297:Male; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D015854:Up-Regulation
chemical_list: C515892:LIMK1 protein, human; D054461:Lim Kinases
keywords: FAK/paxillin; Gastric cancer; LIMK1