title: [Epidemiology of febrile neutropenia in adult patients with acute leukemia and lymphoma: Cohort study of public and private hospital of Santiago, Chile].
abstract: BACKGROUND
  Febrile neutropenia (FN) is a common complication of patients undergoing chemotherapy (QMT). Clinical presentation is varied, from mild fever to severe sepsis with invasive bacterial infection (IBI) or invasive fungal infection (IFI), with great impact on prognosis and patient mortality.
  
  
  METHODS
  Prospective cohort study of FN episodes in adult patients with acute leukemia (AL) or lymphoma (L), diagnosed and treated at the Hospital Clínico Universidad Católica and Hospital Dr. Sótero del Río in Santiago from April 2010 to January 2012.
  
  
  RESULTS
  130 patients were included with 105 episodes of NF, with an incidence of 0.65 per 100 days of observation, higher in AL than L (1.31 vs 0.25, p = 0.001). Etiology or clinical focus was documented in 67 (63.8%) episodes, with IBI in 33 (31.4%) and IFI in 21 (20%) cases. Mortality related to infection occurred in 4 (6.2%) patients.
  
  
  CONCLUSIONS
  This study reports that the FN incidence and frequency of IBI and IFI during episodes are higher in AL vs. L. It is necessary to evaluate the impact of interventions to reduce its incidence, including the benefit and risk of using antibacterial and antifungal prophylaxis in high-risk subgroups.
authors: Ricardo
authors: R
authors: Rabagliati
authors: Pablo
authors: P
authors: Bertín
authors: Inés
authors: I
authors: Cerón
authors: Hernán
authors: H
authors: Rojas
authors: Isabel
authors: I
authors: Domínguez
authors: Álvaro
authors: Á
authors: Vera
authors: Leonardo
authors: L
authors: Sir
authors: Jimena
authors: J
authors: Flores
authors: Paulina
authors: P
authors: Fernández
authors: Marco
authors: M
authors: Pérez
authors: Rolando
authors: R
authors: De La Cruz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000453:epidemiology*; D002677:Chile / Q000453:epidemiology; D005260:Female; D016304:Hospitals, Private; D006779:Hospitals, Public; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult