title: Double trouble: HIV latency and CTL escape.
abstract: HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015) show that this latent reservoir also contains a large number of cytotoxic T lymphocyte escape mutants, presenting another challenge to HIV cure efforts.
authors: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA.
authors: Matthew D
authors: MD
authors: Marsden
authors: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.
authors: Jerome A
authors: JA
authors: Zack
mesh_terms: D000818:Animals; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D017735:Virus Latency / Q000276:immunology*