title: Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition.
abstract: A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.
authors: Centre for Doctoral training at the Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, Bath, BA2 7AY (UK).
authors: Sarah
authors: S
authors: Abou-Shehada
authors: Matthew C
authors: MC
authors: Teasdale
authors: Steven D
authors: SD
authors: Bull
authors: Charles E
authors: CE
authors: Wade
authors: Jonathan M J
authors: JM
authors: Williams
mesh_terms: D003500:Cyclization; D058116:Lewis Acids / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*
chemical_list: D058116:Lewis Acids; D008670:Metals; D011725:Pyridines; C023666:pyridine
keywords: SNAr; amination; conjugate addition; lewis acid; pyridine