title: Association between polymorphisms in IL27 and risk for CHD in a Chinese population.
abstract: BACKGROUND
  IL-27, a member of the IL-12 family, has been involved in maternal tolerance to the foetus and successful pregnancy. Growing evidences indicate that IL-27 plays a crucial role in pregnancy. Aim We carried out the present study in order to investigate whether polymorphisms in the IL27 are associated with the risk for CHDs, including atrial septal defect and ventricular septal defect. Patients and methods We conducted this case-control study among 247 atrial septal defect patients, 150 ventricular septal defect patients, and 368 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay.
  
  
  RESULTS
  Significantly increased risk for atrial septal defect (p=0.001, OR=1.490, 95% CI=1.178-1.887) and ventricular septal defect (p=0.004, OR=1.502, 95% CI=1.139-1.976) was observed to be associated with the allele G of rs153109. In a dominant model, we have also observed that increased susceptibilities for atrial septal defect (p<0.01, OR=1.89, 95% CI=1.35-2.63) and ventricular septal defect (p<0.01, OR=2.50, 95% CI=1.67-3.85) were statistically associated with rs153109; however, no association was found between CHD risk and rs17855750 in the IL27 gene.
  
  
  CONCLUSIONS
  The 153109 of the IL27 gene may be associated with the susceptibility to CHD, including atrial septal defect and ventricular septal defect.
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Danyan
authors: D
authors: Zhang
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Mingfu
authors: M
authors: Ma
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Yuyou
authors: Y
authors: Yang
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Ling
authors: L
authors: Wan
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Zhixi
authors: Z
authors: Yang
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Jing
authors: J
authors: Lv
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Xinsheng
authors: X
authors: Li
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Hao
authors: H
authors: Yang
authors: 4The Third Military Medical University,Chongqing,P.R. China.
authors: Pei
authors: P
authors: Huang
authors: 1Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing,P.R. China.
authors: Lianbing
authors: L
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006330:Heart Defects, Congenital / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007223:Infant; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D007378:Interleukins; C464565:MYDGF protein, human; D004247:DNA
keywords: CHD; IL27; cytokine; genetic susceptibility; polymorphisms