title: Cornell product relates to albuminuria in hypertensive black adults independently of blood pressure: the SABPA study.
abstract: Evidence of the relationship between left ventricular hypertrophy and urinary albumin excretion is contradictory and limited in black adults in whom hypertensive heart disease is common. We aimed to investigate the relationship between subclinical left ventricular hypertrophy and albuminuria in non-diabetic hypertensive blacks. Urinary albumin-to-creatinine ratio (UACR) was determined from 8-hour overnight urine collection. We recorded ambulatory blood pressure and 12-lead electrocardiogram during a typical working day. Cornell product (P = .002), UACR (P = .042), 24-hour systolic pressure (P < .0001), and 24-hour pulse pressure (P < .0001) were higher in the hypertensive group. Cornell product was associated with UACR in single (r = 0.25; P = .012), partial (P trend = .002), and multiple regression (β = 0.326; P = .0005) analyses in the hypertensive group only, even below the threshold for microalbuminuria and independent of 24-hour systolic pressure. Urinary albumin excretion is associated with subclinical left ventricular hypertrophy in non-diabetic hypertensive blacks and may be a useful marker of early cardiovascular disease in blacks.
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa. Electronic address: rudolph.schutte@nwu.ac.za.
authors: Rudolph
authors: R
authors: Schutte
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Hugo W
authors: HW
authors: Huisman
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Lisa J
authors: LJ
authors: Ware
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Catherina M C
authors: CM
authors: Mels
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Wayne
authors: W
authors: Smith
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Nicolaas T
authors: NT
authors: Malan
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Leoné
authors: L
authors: Malan
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Johannes M
authors: JM
authors: van Rooyen
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Carla M T
authors: CM
authors: Fourie
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Ruan
authors: R
authors: Kruger
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Shani
authors: S
authors: Botha
authors: Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors: Aletta E
authors: AE
authors: Schutte
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D044383:Black People; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D003321:Cornell Medical Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology; D014505:Urban Population
keywords: Black adults; albuminuria; subclinical left ventricular hypertrophy