title: Locally derived system for cardiac operative risk evaluation.
abstract: BACKGROUND
  During the last two decades, many authors have found that European Systems for Cardiac Operative Risk Evaluation (additive and logistic models) overestimate the risk in cardiac surgery. The new European model has recently been introduced as an update to previous versions. The aim of the study was to investigate the significance of locally derived system for cardiac operative risk evaluation and to compare its predictive power with the existing European systems.
  
  
  METHODS
  For developing a local risk prediction model, data from 2681 patients submitted to cardiac surgery at the Institute of Cardiovascular Diseases Vojvodina have thoroughly been collected. Logistic regression analysis was used to construct a local model for prediction of outcome. The evaluation of the local model and three European systems was performed by comparing the observed and expected hospital mortality.
  
  
  RESULTS
  The difference between the predicted and observed mortality regardless of the type of surgery was statistically insignificant for the additive European system (p=0.073) and the local model (p=0.134). The logistic European system overestimated the operative risk, while the new European model underestimated mortality. In coronary surgery, all models, except the logistic European system, performed well. In valvular surgery, the new European model and the local model underestimated mortality significantly, while the additive and logistic European models performed well. In combined surgery, the new European system significantly underestimated mortality (p=0.029), while the local model performed well (p=0.252).
  
  
  CONCLUSIONS
  The locally derived model shows satisfactory results, with good calibration and discriminative power. The local model specifically outperforms all other European systems in terms of discriminatory power in combined surgery subset.
authors: Bogoljub
authors: B
authors: Mihajlović
authors: Bojan
authors: B
authors: Mihajlović
authors: Milica
authors: M
authors: Panić
authors: Milana
authors: M
authors: Jaraković
authors: Snežana
authors: S
authors: Bjelica
authors: Melisa
authors: M
authors: Mironicki
mesh_terms: D006348:Cardiac Surgical Procedures / Q000401:mortality*; D003327:Coronary Disease / Q000601:surgery; D006349:Heart Valve Diseases / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome