title: Five-year follow-up observation of HIV prevalence in serodiscordant couples.
abstract: OBJECTIVE
  To evaluate the rate of HIV seroconversion and the related risk factors among HIV discordant couples in Hubei Province, China.
  
  
  METHODS
  HIV seroconversion rates and associated factors in discordant couples were identified during 2010-2012, based on existing data collected in serological and behavioral surveys between 2005 and 2007.
  
  
  RESULTS
  At baseline, HIV transmission had occurred in 505 out of 1258 couples and the annual rate of HIV transmission was 6.3% in the absence of an intervention (40.14% after HIV exposure for 6.4 years). Five out of 753 discordant couples were found to have seroconverted during the 5-year follow-up observation after the implementation of interventions. Factors independently associated with HIV seroconversion included an HIV viral load >1000 copies/ml (odds ratio (OR) 18.706, 95% confidence interval (CI) 1.577-221.926), the index partner being on antiretroviral therapy (OR 0.019, 95% CI 0.002-0.180), and condom use in the past 6 months (OR 0.194, 95% CI 0.021-0.795).
  
  
  CONCLUSIONS
  HIV-negative partners in serodiscordant couples were at risk of HIV infection if the index partner did not receive any intervention. It is strongly advised that existing interventions are used, such as couples consultations, condom use, and antiretroviral treatment, to minimize the risk of HIV transmission.
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China.
authors: Rong-rong
authors: RR
authors: Yang
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China. Electronic address: znact0@126.com.
authors: Xien
authors: X
authors: Gui
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China.
authors: Yong
authors: Y
authors: Xiong
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China.
authors: Shi-cheng
authors: SC
authors: Gao
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China.
authors: Ya-jun
authors: YJ
authors: Yan
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005191:Family Characteristics; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D006679:HIV Seropositivity / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012747:Sexual Partners
keywords: Antiretroviral therapy; Behavioral intervention; Condom; HIV; Serodiscordant couples