title: Emerging strategies for treating brain metastases from breast cancer.
abstract: Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise in preclinical and early clinical settings. This review discusses recent advances in breast cancer brain metastasis therapy and potential approaches for successful treatment.
authors: Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: David P
authors: DP
authors: Kodack
authors: Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Vasileios
authors: V
authors: Askoxylakis
authors: Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Gino B
authors: GB
authors: Ferraro
authors: Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Dai
authors: D
authors: Fukumura
authors: Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jain@steele.mgh.harvard.edu.
authors: Rakesh K
authors: RK
authors: Jain
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D057089:Pathology, Molecular; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases