title: Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
abstract: OBJECTIVE
  Ursodeoxycholic acid is frequently used in cholestatic liver diseases. Also, it protects hepatocytes against oxidative stress induced by hydrophobic bile acids. We investigated the anti-oxidative effect of ursodeoxycholic acid on ischemia/reperfusion injury after ovarian de-torsion in rats.
  
  
  METHODS
  We designed five study groups. Group 1 (n = 6): Sham-operated group; group 2 (n = 6): torsion group; group 3 (n = 6): torsion and ursodeoxycholic acid, group 4 (n = 7): torsion/de-torsion group; and group 5 (n = 7): torsion/de-torsion and ursodeoxycholic acid. After that, ovarian samples were obtained and examined histologically and tissue levels of malondialdehyde were measured.
  
  
  RESULTS
  Follicular degeneration, edema and inflammatory cells were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Also, groups 4 and 5 were compared in terms of vascular congestion and hemorrhage and these were found to be significantly decreased in group 5. In addition, levels of malondialdehyde were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4.
  
  
  CONCLUSIONS
  We concluded that ursodeoxycholic acid might be useful to protect the ovary against ischemia and reperfusion injury.
authors: Department of Obstetrics and Gynecology, Medicine Faculty, Ege University, 35040, Izmir, Turkey.
authors: Ali
authors: A
authors: Akdemir
authors: Cagdas
authors: C
authors: Sahin
authors: Oytun
authors: O
authors: Erbas
authors: Ahmet O
authors: AO
authors: Yeniel
authors: Fatih
authors: F
authors: Sendag
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007511:Ischemia; D008315:Malondialdehyde; D010049:Ovarian Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D010053:Ovary / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014102:Torsion Abnormality / Q000150:complications* / Q000473:pathology; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D014580:Ursodeoxycholic Acid