title: [Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state].
abstract: We report here studies of the effects of subchronic administration of 5-HT1A receptor agonist buspirone and its novel complex with glycyrrhizic acid (GA) to C57BL/6J mice at the different stages of the anxious-depressive state formation, induced by conditions of social stress. The experiment of agents' administration during the conditions of stress (beginning with initial stage) showed that only complex had a protective effect revealed in prevention of the anxiety with the high level of mice communicativeness maintenance. At the stage when the anxious-depressive state is completely formed, buspirone and its complex with GA decreased mice motor activity however complex--less significantly. Here we discuss a possible mechanism of action of investigated agents on the background of changes in the sensitivity of 5-HT1A receptors, induced by the formation of the anxious-depressive state of mice with experience of social stress. Despite of different effects of agents depending on the stage of the anxious-depressive state development, novel buspirone complex with GA has some advantage over buspirone.
authors: M K
authors: MK
authors: Fomina
authors: D F
authors: DF
authors: Avgustinovich
authors: T G
authors: TG
authors: Tolstikova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002065:Buspirone / Q000031:analogs & derivatives / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D019695:Glycyrrhizic Acid / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013315:Stress, Psychological
chemical_list: D014151:Anti-Anxiety Agents; D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D019695:Glycyrrhizic Acid; D002065:Buspirone