title: Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis.
abstract: The aim of this study was to prepare and characterize spray dried inhalable chitosan nanoparticles (CNPs) for sustained delivery of anti-tubercular drugs, isoniazid (INH) and rifampicin (RIF), to the lungs. CNPs were prepared by ionic gelation technique followed spray drying. Results showed that the CNPs obtained had a smooth spherical shape with an average size of 230 ± 4.5 nm, with a poly dispersity index of 0.180 ± 0.021. Both drugs, were detected in various organs (lungs, liver, spleen and kidney) until 24 h post nebulization. The chemotherapeutic efficacy of a single dose of drug-loaded CNPs suggested that they are more effective against the mycobacterium than free drugs.
authors: a Department of Pharmaceutics , Nanomedicine Research Centre, ISF College of Pharmacy, Moga, Punjab Technical University , Kapurthala , Punjab , India.
authors: Tarun
authors: T
authors: Garg
authors: a Department of Pharmaceutics , Nanomedicine Research Centre, ISF College of Pharmacy, Moga, Punjab Technical University , Kapurthala , Punjab , India.
authors: Goutam
authors: G
authors: Rath
authors: a Department of Pharmaceutics , Nanomedicine Research Centre, ISF College of Pharmacy, Moga, Punjab Technical University , Kapurthala , Punjab , India.
authors: Amit K
authors: AK
authors: Goyal
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000904:Antibiotics, Antitubercular / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D012293:Rifampin / Q000737:chemistry / Q000494:pharmacology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D004337:Drug Carriers; D048271:Chitosan; D007538:Isoniazid; D012293:Rifampin
keywords: chitosan nanoparticle; in vivo studies; pulmonary drug delivery; tuberculosis