title: Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention.
abstract: Contrast-induced acute kidney injury (CI-AKI) is a major issue after percutaneous coronary intervention (PCI), especially in the setting of acute coronary syndrome (ACS). Contrast-induced acute kidney injury is associated with increased mortality and morbidity. Inflammation plays an important role in the pathophysiology of CI-AKI. Procalcitonin (PCT) is introduced as a new marker of inflammation. We sought to examine whether admission PCT levels predict the development of CI-AKI. Patients (n = 814) were divided into 2 groups, namely, CI-AKI (-) and CI-AKI (+). An increase in serum creatinine of ≥0.5 mg/dL from baseline within 48 to 72 hours of contrast exposure was defined as CI-AKI. Contrast-induced acute kidney injury occurred in 96 (11.8%) patients. The PCT levels were significantly higher in patients with CI-AKI than in those without, 0.11 (0.056-0.495) vs 0.04 (0.02-0.078) µg/L; P < .001. After multivariable analysis, PCT remained a significant independent predictor of CI-AKI (odds ratio 2.544; 95% CI [1.207-5.347]; P = .014) as well as age, women, white blood cell, hemoglobin, glomerular filtration rate, creatine kinase myocarial band, and SYNTAX score. In conclusion, serum PCT levels are independently associated with a risk of CI-AKI in patients with ACS who underwent urgent PCI.
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey alpkurtul@yahoo.com.
authors: Alparslan
authors: A
authors: Kurtul
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Sani Namik
authors: SN
authors: Murat
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Mikail
authors: M
authors: Yarlioglues
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Duran
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Adil Hakan
authors: AH
authors: Ocek
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Ibrahim Etem
authors: IE
authors: Celik
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Alparslan
authors: A
authors: Kilic
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Cemal
authors: C
authors: Koseoglu
authors: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Fatih
authors: F
authors: Oksuz
authors: Department of Cardiology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors: Veysel Ozgur
authors: VO
authors: Baris
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000097:blood*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D003287:Contrast Media; D018836:Inflammation Mediators; D011498:Protein Precursors; D002116:Calcitonin; D003404:Creatinine; D015740:Calcitonin Gene-Related Peptide
keywords: acute coronary syndrome; contrast-induced acute kidney injury; percutaneous coronary intervention; procalcitonin