title: Difference in benefit of chemotherapy between small cell lung cancer patients with interstitial pneumonia and patients with non-small cell lung cancer.
abstract: BACKGROUND
  It is not clear whether there is a difference in benefit of chemotherapy between small cell lung cancer (SCLC) patients with pre-existing idiopathic interstitial pneumonias (IIPs) and non-small cell lung cancer (NSCLC) patients with IIPs.
  
  
  METHODS
  We performed a retrospective study of the overall survival (OS) between advanced lung cancer patients with IIPs (n=28) and those without IIPs (n=145).
  
  
  RESULTS
  The OS in NSCLC patients with IIPs was shorter than in those without IIPs (median OS, 10.6 vs. 27.9 months, p=0.008) but the OS in SCLC patients with IIPs was not inferior to that of those without IIPs (12.7 vs. 14.8 months, p=0.835). Multivariate analysis showed that the small number of regimens increased the risk of mortality, instead of pre-existing IIPs.
  
  
  CONCLUSIONS
  The continuation of chemotherapy in SCLC patients with IIPs made it possible to have a similar prognosis to that in those without IIPs.
authors: Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan kskkswbr@krmc.or.jp.
authors: Kosuke
authors: K
authors: Kashiwabara
authors: Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan.
authors: Hiroshi
authors: H
authors: Semba
authors: Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan.
authors: Shinji
authors: S
authors: Fujii
authors: Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan.
authors: Shinsuke
authors: S
authors: Tsumura
authors: Department of Respiratory Medicine, Kumamoto Regional Medical Center, Kumamoto, Japan.
authors: Ryota
authors: R
authors: Aoki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
keywords: Small cell lung cancer; drug-induced interstitial lung disease; idiopathic interstitial pneumonia; non-small cell lung cancer; number of regimens