title: Reversible Splenial Lesion Syndrome (RESLES) Following Glufosinate Ammonium Poisoning.
abstract: Isolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high-altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39-year-old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion-weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow-up MR imaging performed 9 months later. We postulate that a GLA-induced excitotoxic mechanism was the cause of this reversible splenial lesion.
authors: Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.
authors: Tae Oh
authors: TO
authors: Jeong
authors: Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.
authors: Jae Chol
authors: http://orcid.org/0000-0001-8781-9622
authors: JC
authors: Yoon
authors: Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.
authors: Jae Baek
authors: JB
authors: Lee
authors: Research Institute of Clinical Medicine of Chonbuk National University, Emergency Medicine, Jeonju-si, Republic of Korea.
authors: Young Ho
authors: YH
authors: Jin
authors: Chonbuk National University Medical School and Hospital, Radiology, Jeonju-si, Republic of Korea.
authors: Seung Bae
authors: SB
authors: Hwang
mesh_terms: D000328:Adult; D000613:Aminobutyrates / Q000506:poisoning*; D001929:Brain Edema / Q000139:chemically induced / Q000000981:diagnostic imaging*; D003337:Corpus Callosum / Q000000981:diagnostic imaging* / Q000187:drug effects; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D012075:Remission, Spontaneous; D012640:Seizures / Q000139:chemically induced / Q000000981:diagnostic imaging*
chemical_list: D000613:Aminobutyrates; C003121:phosphinothricin
keywords: Corpus callosum; cytotoxic edema; glufosinate ammonium