title: Contribution of double strand break repair gene XRCC3 genotypes to nasopharyngeal carcinoma risk in Taiwan.
abstract: The DNA double strand break repair protein XRCC3 plays a central role in removing double strand breaks from the genome and defects in cellular repair capacity is closely related to human cancer initiation. Therefore, we aimed to investigate the contribution of XRCC3 genotypes to individual nasopharyngeal carcinoma (NPC) susceptibility. In this hospital-based population research, the genotyping and analyzing of XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 in a large Taiwanese population was performed. Totally, 176 NPC patients and 880 age- and gender-matched healthy controls were genotyped and analyzed by PCR-RFLP method. The results showed that there was a differential distribution among NPC and control subjects in the genotypic (P = 0.000488) and allelic (P = 0.0002) frequencies of XRCC3 rs861539. As for the gene-environment interaction, we have firstly provided evidence showing that there is an obvious joint effect of XRCC3 rs861539 CT and TT genotypes with individual smoking habits on increased NPC risk. In conclusion, the T allele of XRCC3 rs861539, interacts with smoking habit in increasing NPC risk, may be an early detection marker for NPC.
authors: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan, Republic of China.
authors: Juhn-Cherng
authors: JC
authors: Liu
authors: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan, Republic of China.
authors: Chia-Wen
authors: CW
authors: Tsai
authors: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung 40458, Taiwan, Republic of China.
authors: Chin-Mu
authors: CM
authors: Hsu
authors: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan, Republic of China.
authors: Wen-Shin
authors: WS
authors: Chang
authors: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan, Republic of China.
authors: Chi-Yuan
authors: CY
authors: Li
authors: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung 40458, Taiwan, Republic of China.
authors: Shih-Ping
authors: SP
authors: Liu
authors: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung 40458, Taiwan, Republic of China.
authors: Wu-Chung
authors: WC
authors: Shen
authors: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung 40458, Taiwan, Republic of China.
authors: Da-Tian
authors: DT
authors: Bau
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000209:etiology / Q000235:genetics*; D012306:Risk; D013624:Taiwan
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3