title: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses.
abstract: Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing.
authors: Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge MA, USA 02139. lgehrke@mit.edu.
authors: Chun-Wan
authors: CW
authors: Yen
authors: Helena
authors: H
authors: de Puig
authors: Justina O
authors: JO
authors: Tam
authors: José
authors: J
authors: Gómez-Márquez
authors: Irene
authors: I
authors: Bosch
authors: Kimberly
authors: K
authors: Hamad-Schifferli
authors: Lee
authors: L
authors: Gehrke
mesh_terms: D003716:Dengue Virus / Q000302:isolation & purification*; D029043:Ebolavirus / Q000302:isolation & purification*; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D019095:Point-of-Care Systems; D012834:Silver / Q000737:chemistry*; D013057:Spectrum Analysis; D014773:Virology / Q000295:instrumentation* / Q000379:methods; D014777:Virus Diseases / Q000097:blood / Q000821:virology; D015005:Yellow fever virus / Q000302:isolation & purification*
chemical_list: D012834:Silver