title: [Lipid peroxidation in the rat liver following skeletal injury].
abstract: We assessed the concentrations of the products of lipid peroxidation (conjugated dienes--CD, malone dialdegide--MDA), the activity of catalase and the total lipids in the rat liver following tibial fractures. The experiment was carried out using sixty adult male Wistar rats. In group 1 (n = 30), tibial fractures were modeled and fixed with the apparatus of external fixation. In control group 2 (n = 30), the external apparatus was applied to the tibias but the fractures were not modeled. In group 1 animals, the absolute concentrations of CD and MDA were statistically reduced at each time-point studied. The concentration of CD in group 2 was significantly lower on day 3 while the level of MDA up to day 14 of the experiment than in the intact rats. The level of total lipids on days 3 and 7 was decreased in group 1 while in group 2 it was lower than the intact values on days 3 through 14. The catalase activity in group 1 was statistically elevated from day 7 of the experiment as compared to the intact rats. No significant changes in the activity of catalase were found in group 2 at all time-points of the experiment.
authors: M V
authors: MV
authors: Stogov
authors: E A
authors: EA
authors: Kireeva
authors: A A
authors: AA
authors: Emanov
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D016267:External Fixators; D005592:Fracture Fixation / Q000295:instrumentation / Q000379:methods; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000293:injuries*; D013978:Tibial Fractures / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde; D002374:Catalase