title: FOXP3+ regulatory T cells and their functional regulation.
abstract: FOXP3(+) regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.
authors: Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors: Zhiyuan
authors: Z
authors: Li
authors: Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors: Dan
authors: D
authors: Li
authors: Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.|Innovent Biologics Inc., Suzhou, China.
authors: Andy
authors: A
authors: Tsun
authors: Unit of Molecular Immunology, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors: Bin
authors: B
authors: Li
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D051858:Forkhead Transcription Factors