title: Cu-bearing steel reduce inflammation after stent implantation.
abstract: Copper (Cu)-bearing stainless steel with release of Cu2+ ions is a novel material for coronary stents that could reduce the in-stent restenosis after the stent implantation. The inflammation has been recently recognized as an important factor to smooth muscle cells proliferation, thrombosis, and hence the restenosis post-angioplasty. The objective of this study is to further investigate the effect and relevant mechanism of Cu-bearing stainless steel (316L-Cu SS) on the inflammation reaction after stent implantation. The results demonstrated that, compared with commercial coronary stent material (316L SS), 316L-Cu SS could inhibit the inflammation caused by endothelial dysfunction through blockading the inflammatory factors (TNF-α, IL-1β, 6, 8), which would then reduce the recruitment and infiltration of leukocytes, rather than have direct effect on leukocytes. This finding further explained the reduction effect of 316L-Cu SS on in-stent restenosis from a novel view.
authors: The First Affiliated Hospital, Liaoning Medical College, 5-2 Renmin Street, Jinzhou, 121000, China, medicaldoctor33@sina.com.
authors: Jinzhao
authors: J
authors: Li
authors: Ling
authors: L
authors: Ren
authors: Shuyuan
authors: S
authors: Zhang
authors: Guogang
authors: G
authors: Ren
authors: Ke
authors: K
authors: Yang
mesh_terms: D000497:Alloys / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D023903:Coronary Restenosis / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D016207:Cytokines / Q000276:immunology; D019544:Equipment Failure Analysis; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D008422:Materials Testing; D018375:Neutrophil Activation / Q000276:immunology; D011474:Prosthesis Design; D013193:Stainless Steel / Q000737:chemistry*; D015607:Stents / Q000009:adverse effects*
chemical_list: D000497:Alloys; D016207:Cytokines; D013193:Stainless Steel; D003300:Copper