title: Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography.
abstract: Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema in vivo. Three-dimensional imaging of an in vivo water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was calculated and cerebral blood flow was analyzed using Doppler OCT techniques. We found that the average attenuation coefficient in the cerebral cortex decreased over time as edema progressed. The initial decrease began within minutes of inducing cerebral edema and a maximum decrease of 8% was observed by the end of the experiment. Additionally, cerebral blood flow slowed during late-stage edema. Analysis of local regions revealed the same trend at various locations in the brain, consistent with the global nature of the cerebral edema model used in this study. These results demonstrate that OCT is capable of detecting in vivo optical changes occurring due to cerebral edema and highlights the potential of OCT for precise spatiotemporal detection of cerebral edema.
authors: University of California Riverside , Department of Bioengineering, 900 University Avenue, Riverside, California 92521, United States.
authors: Carissa L R
authors: CL
authors: Rodriguez
authors: University of California Riverside , Division of Biomedical Sciences, School of Medicine, 900 University Avenue, Riverside, California 92521, United States.
authors: Jenny I
authors: JI
authors: Szu
authors: University of California Riverside , Department of Bioengineering, 900 University Avenue, Riverside, California 92521, United States.
authors: Melissa M
authors: MM
authors: Eberle
authors: Massachusetts General Hospital and Harvard Medical School , Pulmonary and Critical Care Unit, 55 Fruit Street, Boston, Massachusetts 02114, United States.
authors: Yan
authors: Y
authors: Wang
authors: University of California Riverside , Division of Biomedical Sciences, School of Medicine, 900 University Avenue, Riverside, California 92521, United States ; Umbrella Neurotechnologies , Irvine, California 92620, United States.
authors: Mike S
authors: MS
authors: Hsu
authors: University of California Riverside , Division of Biomedical Sciences, School of Medicine, 900 University Avenue, Riverside, California 92521, United States ; Umbrella Neurotechnologies , Irvine, California 92620, United States.
authors: Devin K
authors: DK
authors: Binder
authors: University of California Riverside , Department of Bioengineering, 900 University Avenue, Riverside, California 92521, United States.
authors: B Hyle
authors: BH
authors: Park
keywords: brain swelling; cerebral edema; optical coherence tomography