title: MIND diet associated with reduced incidence of Alzheimer's disease.
abstract: BACKGROUND
  In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD).
  
  
  METHODS
  We investigated the diet-AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire.
  
  
  RESULTS
  In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates.
  
  
  CONCLUSIONS
  High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk.
authors: Department of Internal Medicine and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.
authors: Martha Clare
authors: MC
authors: Morris
authors: Department of Clinical Nutrition and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.
authors: Christy C
authors: CC
authors: Tangney
authors: Department of Internal Medicine and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.
authors: Yamin
authors: Y
authors: Wang
authors: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors: Frank M
authors: FM
authors: Sacks
authors: Department of Behavioral Sciences and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA; Department of Neurology and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.
authors: David A
authors: DA
authors: Bennett
authors: Department of Behavioral Sciences and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA; Department of Neurology and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.
authors: Neelum T
authors: NT
authors: Aggarwal
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000178:diet therapy* / Q000453:epidemiology* / Q000503:physiopathology; D002641:Chicago / Q000453:epidemiology; D003072:Cognition Disorders / Q000178:diet therapy / Q000453:epidemiology / Q000503:physiopathology; D038441:Diet, Mediterranean; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010349:Patient Compliance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016019:Survival Analysis
keywords: Aging; Alzheimer's disease; Cognition; Epidemiological study; Nutrition; diet