title: [The effect of anabasine on mortality and concentration of proinflammatory cytokines in blood of mice at early stage of sepsis].
abstract: It was established in experiments on noninbred mice that activation of α-7n acetylcholine receptors (α-7n AChR) by anabasine in single doses of 1.0 and 5.0 mg/kg for 2 h before modeling sepsis (intraperitoneal injection of E. coli) cause a significant dose-dependent reduction of mortality of mice due to a decrease in the amount of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in the blood. Anabasine in single doses of 0.1 mg/kg had no significant impact on the studied parameters.
authors: P F
authors: PF
authors: Zabrodskiĭ
authors: M S
authors: MS
authors: Gromov
authors: V V
authors: VV
authors: Masliakov
mesh_terms: D000691:Anabasine / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D004306:Dose-Response Relationship, Immunologic; D004926:Escherichia coli / Q000254:growth & development / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D005260:Female; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D018722:Nicotinic Agonists / Q000494:pharmacology*; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000819:agonists* / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D018722:Nicotinic Agonists; D014409:Tumor Necrosis Factor-alpha; D064569:alpha7 Nicotinic Acetylcholine Receptor; D000691:Anabasine