title: The subthalamic nucleus, oscillations, and conflict.
abstract: The subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation (DBS) for Parkinson's disease (PD), has received increased attention over the past few years for the roles it may play in functions beyond simple motor control. In this article, we highlight several of the theoretical, interventional, and electrophysiological studies that have implicated the STN in response inhibition. Most influential among this evidence has been the reported effect of STN DBS in increasing impulsive responses in the laboratory setting. Yet, how this relates to pathological impulsivity in patients' everyday lives remains uncertain.
authors: Experimental Neurology Group, Nuffield Department of Clinical Neurology, University of Oxford John Radcliffe Hospital, Oxford, UK; Surgical Neurology Branch, National Institutes of Health, Bethesda, MD, USA.
authors: Baltazar
authors: B
authors: Zavala
authors: Kareem
authors: K
authors: Zaghloul
authors: Peter
authors: P
authors: Brown
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods; D006801:Humans; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000502:physiology*
keywords: Parkinson's disease; conflict; deep brain stimulation; impulsiveness; subthalamic nucleus