title: CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children.
abstract: OBJECTIVE
  Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children.
  
  
  METHODS
  We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n=116, age=8±0.5 years) who were divided into two groups: obese (n=57; body mass index (BMI) z-score=2.513±0.490) and lean children (n=59; BMI z-score=-0.138±0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for A/G SNP rs1761667 in 5'UTR region of CD36 by using PCR and restriction fragment length polymorphism.
  
  
  RESULTS
  We noticed significantly higher CD36 A-allele frequency (P=0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children.
  
  
  CONCLUSIONS
  CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.
authors: Laborartoire de Biologie Cellulaire and Moléculaire, Université de Constantine 1, Constantine, Algérie.
authors: A
authors: A
authors: Sayed
authors: 1] Institute of Animal Physiology and Genetics, Academy of Science, Brno, Czech Republic [2] Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
authors: O
authors: O
authors: Šerý
authors: 1] Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic [2] Physiologie de la Nutrition and Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, Dijon, France.
authors: J
authors: J
authors: Plesnik
authors: Laborartoire de Biologie Cellulaire and Moléculaire, Université de Constantine 1, Constantine, Algérie.
authors: H
authors: H
authors: Daoudi
authors: Laborartoire de Biologie Cellulaire and Moléculaire, Université de Constantine 1, Constantine, Algérie.
authors: A
authors: A
authors: Rouabah
authors: Laborartoire de Biologie Cellulaire and Moléculaire, Université de Constantine 1, Constantine, Algérie.
authors: L
authors: L
authors: Rouabah
authors: Physiologie de la Nutrition and Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, Dijon, France.
authors: N A
authors: NA
authors: Khan
mesh_terms: D000462:Algeria / Q000453:epidemiology; D015992:Body Mass Index; D018955:CD36 Antigens / Q000235:genetics*; D002648:Child; D004041:Dietary Fats; D005247:Feeding Behavior; D005260:Female; D005518:Food Preferences; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D019301:Oleic Acid / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D011795:Surveys and Questionnaires; D055697:Taste Perception / Q000235:genetics*; D013851:Thinness / Q000235:genetics* / Q000378:metabolism; D055105:Waist Circumference
chemical_list: D018955:CD36 Antigens; D004041:Dietary Fats; D019301:Oleic Acid