title: Pivotal role for decorin in angiogenesis.
abstract: Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly collagenous and non-collagenous matrix constituents. In this review we have focused on the role and potential mechanisms of a multifunctional small leucine-rich proteoglycan decorin in angiogenesis. Depending on the cellular and molecular microenvironment where angiogenesis occurs, decorin can exhibit either a proangiogenic or an antiangiogenic activity. Nevertheless, in tumorigenesis-associated angiogenesis and in various inflammatory processes, particularly foreign body reactions and scarring, decorin exhibits an antiangiogenic activity, thus providing a potential basis for the development of decorin-based therapies in these pathological situations.
authors: Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland; Department of Medicine, Division of Endocrinology, Turku University Hospital, Turku, Finland. Electronic address: hannu.jarvelainen@utu.fi.
authors: Hannu
authors: H
authors: Järveläinen
authors: Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.
authors: Annele
authors: A
authors: Sainio
authors: Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
authors: Thomas N
authors: TN
authors: Wight
mesh_terms: D020533:Angiogenesis Inhibitors / Q000378:metabolism; D000818:Animals; D060833:Cellular Microenvironment; D058575:Decorin / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic
chemical_list: D020533:Angiogenesis Inhibitors; C546878:DCN protein, human; D058575:Decorin
keywords: Angiogenesis; Decorin; Extracellular matrix; Mechanism; Proteoglycan; Therapy