title: Improvement of small intestinal microcirculation by postconditioning after lower limb ischemia.
abstract: BACKGROUND
  Major lower limb vascular surgeries may result in severe, remote injury of the gastrointestinal system, which has high mortality rates. Postconditioning is a technique with potential capability of reducing remote gastrointestinal complications. Our aim was to assess the remote macro- and micro-hemodynamic changes of the small intestine following an infrarenal aortic occlusion and to evaluate the effects of postconditioning on these alterations.
  
  
  METHODS
  Rats underwent 3h of infrarenal aortic occlusion followed by 4h of reperfusion. In one group, postconditioning was applied. Blood pressure, superior mesenteric artery flow and mucosal microcirculation of the duodenum, jejunum and ileum were assessed. Samples were taken from each intestinal segment for histological examinations.
  
  
  RESULTS
  Superior mesenteric artery flow, as well as microcirculation of the duodenum, jejunum and ileum showed significant impairment in the IR group, while histological damage was significantly worsened. Postconditioning was able to limit flow reduction in all three small bowel segments and in the superior mesenteric artery, and was able to significantly reduce histological damage. Strong negative correlation was found between microcirculatory values and histological damage.
  
  
  CONCLUSIONS
  Microcirculatory impairment might be responsible for remote intestinal injury following infrarenal aortic occlusion. Postconditioning was able to reduce this remote intestinal damage.
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary. Electronic address: zsturoczi@gmail.com.
authors: Zsolt
authors: Z
authors: Turóczi
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary.
authors: András
authors: A
authors: Fülöp
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary.
authors: Zoltán
authors: Z
authors: Czigány
authors: Institute of Surgical Research, University of Szeged, 6 Szökefalvi-Nagy Str., Szeged H-6720, Hungary.
authors: Gabriella
authors: G
authors: Varga
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary.
authors: Oliver
authors: O
authors: Rosero
authors: Institute of Surgical Research, University of Szeged, 6 Szökefalvi-Nagy Str., Szeged H-6720, Hungary.
authors: Tünde
authors: T
authors: Tökés
authors: Institute of Surgical Research, University of Szeged, 6 Szökefalvi-Nagy Str., Szeged H-6720, Hungary.
authors: József
authors: J
authors: Kaszaki
authors: 2nd Department of Pathology, Semmelweis University, 91 Üllöi Str., Budapest H-1091, Hungary.
authors: Gábor
authors: G
authors: Lotz
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary.
authors: László
authors: L
authors: Harsányi
authors: 1st Department of Surgery, Semmelweis University, 78 Üllöi Str., Budapest H-1082, Hungary.
authors: Attila
authors: A
authors: Szijártó
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology*; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D001794:Blood Pressure; D004195:Disease Models, Animal; D006439:Hemodynamics; D007413:Intestinal Mucosa / Q000098:blood supply; D007421:Intestine, Small / Q000473:pathology*; D007511:Ischemia / Q000473:pathology*; D057775:Ischemic Postconditioning; D008297:Male; D017538:Mesenteric Artery, Superior / Q000473:pathology; D008833:Microcirculation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology
keywords: Lower limb ischemia; Microcirculation; Postconditioning; Small intestine; Superior mesenteric artery flow