title: First report of macrolide resistance gene erm(T) harbored by a novel small plasmid from Erysipelothrix rhusiopathiae.
abstract: The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G+C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fold the MICs of clindamycin and erythromycin for E. rhusiopathiae. The fitness cost of pER29 could be responsible for the low frequency of erm(T) in E. rhusiopathiae.
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Chang-Wen
authors: CW
authors: Xu
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: An-Yun
authors: AY
authors: Zhang
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Chun-Mei
authors: CM
authors: Yang
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Yun
authors: Y
authors: Pan
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Zhong-Bin
authors: ZB
authors: Guan
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Chang-Wei
authors: CW
authors: Lei
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Lin-Yao
authors: LY
authors: Peng
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China.
authors: Qing-Zhou
authors: QZ
authors: Li
authors: College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-resources and Eco-environment, Ministry of Education; and 985 Project Science Innovative Platform for Resource and Environment Protection of Southwestern China, Chengdu, Sichuan, People's Republic of China whongning@163.com.
authors: Hong-Ning
authors: HN
authors: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004888:Erysipelothrix / Q000201:enzymology* / Q000235:genetics; D004889:Erysipelothrix Infections / Q000382:microbiology; D004917:Erythromycin / Q000494:pharmacology; D005798:Genes, Bacterial / Q000235:genetics; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D016366:Open Reading Frames / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin