title: Verification and standardization of blood cell counters for routine clinical laboratory tests.
abstract: The use of automated blood cell counters (automated hematology analyzers) for diagnostic purposes is inextricably linked to clinical laboratories. However, the need for uniformity among the various methods and parameters is increasing and standardization of the automated analyzers is therefore crucial. Standardization not only involves procedures based on reference methods but it also involves validation, verification, quality assurance, and quality control, and it includes the involvement of several participants. This article discusses the expert guidelines and provides an overview of issues involved in complete blood count parameter reference methods and standardization of reporting units.
authors: Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, PO Box: 85500, Utrecht 3508 GA, The Netherlands.
authors: Sue Ellen
authors: SE
authors: Verbrugge
authors: Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, PO Box: 85500, Utrecht 3508 GA, The Netherlands. Electronic address: a.huisman@umcutrecht.nl.
authors: Albert
authors: A
authors: Huisman
mesh_terms: D001772:Blood Cell Count / Q000295:instrumentation* / Q000592:standards; D017408:Guidelines as Topic; D012015:Reference Standards; D054928:Validation Studies as Topic
keywords: Automated blood cell counter; Clinical hematology laboratory; Hematology analyzers; Standardization; Validation; Verification