title: Plasma and synovial fluid autotaxin correlate with severity in knee osteoarthritis.
abstract: BACKGROUND
  This study aimed to investigate the relationships between plasma and synovial autotaxin and the severity in knee osteoarthritis (OA) patients.
  
  
  METHODS
  A total of 90 participants (70 knee OA patients and 20 controls) were recruited. Autotaxin and high-sensitivity C-reactive protein (hs-CRP) levels were determined. The symptomatic and radiographic severity of OA was assessed using the Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores and the Kellgren-Lawrence grades.
  
  
  RESULTS
  OA patients had significantly higher circulating autotaxin and hs-CRP than controls. Plasma autotaxin was directly correlated with synovial fluid autotaxin (r=0.639, P<0.001). Additionally, plasma and synovial fluid autotaxin were associated with radiographic severity (P<0.001). Furthermore, plasma and synovial fluid autotaxin levels were positively correlated with WOMAC scores (r=0.558, P<0.001 and r=0.371, P=0.002, respectively).
  
  
  CONCLUSIONS
  Plasma and synovial fluid autotaxin levels were positively correlated with the severity of OA. Thus, autotaxin has potential as a biomarker reflecting the severity of knee OA.
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Thomas
authors: T
authors: Mabey
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Pimpisa
authors: P
authors: Taleongpong
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Wanvisa
authors: W
authors: Udomsinprasert
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Napaphat
authors: N
authors: Jirathanathornnukul
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand. Electronic address: Sittisak.H@chula.ac.th.
authors: Sittisak
authors: S
authors: Honsawek
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000473:pathology*; D010727:Phosphoric Diester Hydrolases / Q000032:analysis* / Q000097:blood*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry*; D000099189:Lysophospholipase D
chemical_list: D010727:Phosphoric Diester Hydrolases; D000099189:Lysophospholipase D
keywords: Autotaxin; Osteoarthritis; Plasma; Severity; Synovial fluid