title: NUT midline carcinoma presenting with bilateral ovarian metastases: a case report.
abstract: Nuclear protein of the testis (NUT) midline carcinoma (NMC) is an uncommon, relatively recently characterized carcinoma, which is defined by NUT gene rearrangements. We are reporting a case of NMC in a 38-year-old female who presented with pleural effusion and bilateral ovarian masses. We also discuss some of the difficulties encountered by the practicing pathologist in reaching the diagnosis and the role of ancillary studies. Immunohistochemical staining using a commercially available monoclonal antibody showing nuclear expression of the NUT protein is diagnostic of NMC. Dual-color split-apart fluorescence in situ hybridization (FISH) or reverse transcription polymerase chain reaction (RT-PCR) can be used to characterize the fusion gene, whether BRD4-NUT or BRD3-NUT, or NUT-variant.
authors: Department of Pathology (E.D.) Department of Surgery, Division of Cardiothoracic Surgery (A.C.) Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care (S.B.) Department of Obstetrics and Gynecology, Division of Gynecologic Oncology (W.C.), VCU Health System, Richmond, Virginia Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (C.F.).
authors: Ema
authors: E
authors: Dragoescu
authors: Christopher
authors: C
authors: French
authors: Anthony
authors: A
authors: Cassano
authors: Sherman
authors: S
authors: Baker
authors: Weldon
authors: W
authors: Chafe
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000556:secondary*; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000473:pathology*; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000556:secondary*
chemical_list: C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins