title: Risk profile of breast cancer following atypical hyperplasia detected through organized screening.
abstract: BACKGROUND
  Few population-based data are available indicating the breast cancer risk following detection of atypia within a breast screening program.
  
  
  METHODS
  Prospectively collected data from the South Australian screening program were linked with the state cancer registry. Absolute and relative breast cancer risk estimates were calculated for ADH and ALH separately, and by age at diagnosis and time since diagnosis. Post-hoc analysis was undertaken of the effect of family history on breast cancer risk.
  
  
  RESULTS
  Women with ADH and ALH had an increase in relative risk for malignancy (ADH HR 2.81 [95% CI 1.72, 4.59] and (ALH HR 4.14 [95% CI 1.97, 8.69], respectively. Differences in risk profile according to time since diagnosis and age at diagnosis were not statistically significant.
  
  
  CONCLUSIONS
  Estimates of the relative risk of breast cancer are necessary to inform decisions regarding clinical management and/or treatment of women with ADH and ALH.
authors: School of Population Health, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia. Electronic address: elizabeth.buckley@unisa.edu.au.
authors: Elizabeth
authors: E
authors: Buckley
authors: School of Population Health, University of Adelaide, Level 7, 178 North Terrace, Adelaide, South Australia 5005, Australia.
authors: Tom
authors: T
authors: Sullivan
authors: BreastScreen SA, 1 Goodwood Rd, Wayville, South Australia 5034, Australia.
authors: Gelareh
authors: G
authors: Farshid
authors: School of Health Sciences, Faculty of Health, Arts and Design, Swinburne University of Technology, Mail no H24, PO Box 218, Hawthorn, Victoria 3122, Australia.
authors: Janet
authors: J
authors: Hiller
authors: School of Population Health, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia.
authors: David
authors: D
authors: Roder
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000209:etiology / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000209:etiology / Q000473:pathology; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013021:South Australia; D013997:Time Factors
keywords: Atypia; Breast screening; Ductal carcinoma in-situ; Invasive breast cancer; Mammography; Survival analysis