title: Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review.
abstract: OBJECTIVE
  To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.
  
  
  METHODS
  A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.
  
  
  METHODS
  Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.
  
  
  RESULTS
  Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.
  
  
  CONCLUSIONS
  The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.
authors: Department of Psychiatry, University of Oxford, Oxford, UK; Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK; Warneford Hospital, Oxford Health NHS Foundation Trust, Oxford, UK. Electronic address: matthew.broome@psych.ox.ac.uk.
authors: Matthew R
authors: MR
authors: Broome
authors: Department of Psychology, Institute of Psychiatry, King's College of London, London, UK.
authors: Zhimin
authors: Z
authors: He
authors: Oxford University Medical School, University of Oxford, Oxford, UK.
authors: Mashal
authors: M
authors: Iftikhar
authors: Department of Psychology, University of Warwick, Coventry, UK.
authors: Julie
authors: J
authors: Eyden
authors: Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK; Early Intervention Service, Swanswell Point, Coventry and Warwickshire Partnership Trust, Coventry, UK.
authors: Steven
authors: S
authors: Marwaha
mesh_terms: D001921:Brain / Q000503:physiopathology*; D006801:Humans; D019964:Mood Disorders / Q000503:physiopathology*
keywords: Affective; Bipolar; Borderline; Dysregulation; Emotion; Instability; Lability; Mood; RDoC