title: Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism.
abstract: A 71-year-old woman with type 2 diabetes mellitus, chronic kidney disease stage IV, primary hypothyroidism and osteoarthritis, whose prescribed treatment included miglitol 50 mg thrice daily with the first bite of meals, reported that she suffered visual hallucinations while taking miglitol, which resolved within a few days of stopping the drug. When she resumed miglitol, hallucinations recurred within a few days and again resolved within a few days of stopping the drug. To our knowledge, this is the first reported case of hallucinations associated with the use of an α-glucosidase inhibitor and highlights a previously unappreciated risk associated with the use of this generally quite benign drug class.
authors: Department of Internal Medicine, Woodhull Medical Center, New York, New York, USA.
authors: George Chinedu
authors: GC
authors: Ezeji
authors: Department of Internal Medicine, Woodhull Medical Center, Brooklyn, New York, USA.
authors: Taiga
authors: T
authors: Inoue
authors: Department of Internal Medicine, Woodhull Medical Center, Brooklyn, New York, USA.
authors: Gul
authors: G
authors: Bahtiyar
authors: Department of Internal Medicine, Woodhull Medical Center, Brooklyn, New York, USA.
authors: Alan
authors: A
authors: Sacerdote
mesh_terms: D017485:1-Deoxynojirimycin / Q000009:adverse effects / Q000031:analogs & derivatives*; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D065089:Glycoside Hydrolase Inhibitors / Q000009:adverse effects; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007037:Hypothyroidism / Q000150:complications*; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; C045621:miglitol; D017485:1-Deoxynojirimycin