title: Sugar and pH dual-responsive snap-top nanocarriers based on mesoporous silica-coated Fe3O4 magnetic nanoparticles for cargo delivery.
abstract: A facile strategy to prepare snap-top magnetic nanocarriers has been developed where ultrasmall superparamagnetic Fe3O4 nanoparticles were used as the core with mesoporous silica as the shell followed by the covalent installation of a layer of β-cyclodextrins on the outer surfaces. The smart hybrid nanomaterials showed remarkable pH- and sugar-responsive cargo release property and low cytotoxicity as proved by an MTT assay with HEK293T cell lines.
authors: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. ywyang@jlu.edu.cn.
authors: Xi-Long
authors: XL
authors: Qiu
authors: Qing-Lan
authors: QL
authors: Li
authors: Yue
authors: Y
authors: Zhou
authors: Xiao-Yu
authors: XY
authors: Jin
authors: Ai-Di
authors: AD
authors: Qi
authors: Ying-Wei
authors: YW
authors: Yang
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003683:Dehydroascorbic Acid / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D065546:Drug Liberation; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide; D003683:Dehydroascorbic Acid