title: Preferential Enrichment of DL-Leucine Using Cocrystal Formation With Oxalic Acid Under Nonequilibrium Crystallization Conditions.
abstract: By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL-leucine (Leu) using a 1:1 cocrystal (DL-) of DL-Leu and oxalic acid. The crystal structure analysis of DL- indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution.
authors: Graduate School of Human & Environmental Studies, Kyoto University, Kyoto, Japan.
authors: Kochunnoonny
authors: K
authors: Manoj
authors: Graduate School of Human & Environmental Studies, Kyoto University, Kyoto, Japan.
authors: Hiroki
authors: H
authors: Takahashi
authors: Graduate School of Human & Environmental Studies, Kyoto University, Kyoto, Japan.
authors: Yoko
authors: Y
authors: Morita
authors: Centre for Materials Characterization, National Chemical Laboratory, CSIR-NCL, Pune, India.
authors: Rajesh G
authors: RG
authors: Gonnade
authors: Group of Chemistry, Faculty of Law, Meijigakuin Universiy, Yokohama, Japan.
authors: Sekai
authors: S
authors: Iwama
authors: Graduate School of Human & Environmental Studies, Kyoto University, Kyoto, Japan.
authors: Hirohito
authors: H
authors: Tsue
authors: Graduate School of Human & Environmental Studies, Kyoto University, Kyoto, Japan.
authors: Rui
authors: R
authors: Tamura
mesh_terms: D003460:Crystallization / Q000379:methods*; D018360:Crystallography, X-Ray; D007930:Leucine / Q000737:chemistry*; D019815:Oxalic Acid / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D019815:Oxalic Acid; D007930:Leucine
keywords: chiral resolution; cocrystal formation; leucine; phase transition; preferential enrichment