title: Complete nucleotide sequence analysis of the norovirus GII.4 Sydney variant in South Korea.
abstract: Norovirus is the primary cause of acute gastroenteritis in individuals of all ages. In Australia, a new strain of norovirus (GII.4) was identified in March 2012, and this strain has spread rapidly around the world. In August 2012, this new GII.4 strain was identified in patients in South Korea. Therefore, to examine the characteristics of the epidemic norovirus GII.4 2012 variant in South Korea, we conducted KM272334 full-length genomic analysis. The genome of the gg-12-08-04 strain consisted of 7,558 bp and contained three open reading frame (ORF) composites throughout the whole genome: ORF1 (5,100 bp), ORF2 (1,623 bp), and ORF3 (807 bp). Phylogenetic analyses showed that gg-12-08-04 belonged to the GII.4 Sydney 2012 variant, sharing 98.92% nucleotide similarity with this variant strain. According to SimPlot analysis, the gg-12-08-04 strain was a recombinant strain with breakpoint at the ORF1/2 junction between Osaka 2007 and Apeldoorn 2008 strains. This study is the first report of the complete sequence of the GII.4 Sydney 2012 strain in South Korea. Therefore, this may represent the standard sequence of the norovirus GII.4 2012 variant in South Korea and could therefore be useful for the development of norovirus vaccines.
authors: Department of Microbiology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Ji-Sun
authors: JS
authors: Park
authors: Korea Zoonosis Research Institute, Chonbuk National University, Iksan 570-390, Republic of Korea.
authors: Sung-Geun
authors: SG
authors: Lee
authors: Department of Microbiology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Ji-Young
authors: 0000-0002-9377-6670
authors: JY
authors: Jin
authors: Division of Virology, Gyeonggi Provincial Research Institute of Public Health and Environment, Suwon 440-290, Republic of Korea.
authors: Han-Gil
authors: HG
authors: Cho
authors: Environmental Infrastructure Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.
authors: Weon-Hwa
authors: WH
authors: Jheong
authors: Department of Microbiology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
authors: Soon-Young
authors: SY
authors: Paik
mesh_terms: D017250:Caliciviridae Infections / Q000821:virology*; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D029322:Norovirus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D056910:Republic of Korea