title: Use of psychotropic drugs following venous thromboembolism in youth. A nationwide cohort study.
abstract: BACKGROUND
  The mental health prognosis following a venous thromboembolism in youth has not been investigated comprehensively. Using psychotropic drug purchase as a proxy for mental health status, we investigated this issue in a large cohort of young incident venous thromboembolism patients.
  
  
  METHODS
  Using Danish nationwide administrative registries from the period 1997-2010, we identified 4,132 patients aged 13-33 years with a first-time venous thromboembolism diagnosis and no history of psychotropic drug usage. We sampled comparison cohort of random general population controls, matched individually in a 1:5 ratio based on sex and birth year. Participants were followed in prescription purchase registries for their first psychotropic drug purchase.
  
  
  RESULTS
  Among young venous thromboembolism case cases, the 1-year risk of psychotropic drug purchase was 7.1% (95% confidence interval [CI] 6.3, 7.9) and the 5-year risk 22.1% (95% CI 20.7, 23.5). This was substantially higher than among population controls, with 1- and 5-year risk differences relative to the controls of 4.7% (95% CI 3.9, 5.5), and 10.8% (95% CI 9.4, 12.3), respectively. Adjustment for the effects of recent pregnancy or somatic provocations attenuated risk differences to 4.1% (95% CI 3.5, 5.1) after 1 year and 9.6% (95% CI 8.3, 11.2) after 5 years.
  
  
  CONCLUSIONS
  A venous thromboembolism diagnosis in youth is associated with a poorer mental health prognosis: one in five patients are prescribed psychotropic medication within the first 5 year after diagnosis.
authors: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Clinical Nursing Research Unit, Aalborg University Hospital Science and Innovation Center, Aalborg University Hospital, Aalborg, Denmark; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark. Electronic address: a.wind@rn.dk.
authors: Anette Arbjerg
authors: AA
authors: Højen
authors: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
authors: Anders
authors: A
authors: Gorst-Rasmussen
authors: Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark; Centre for Cardiovascular Sciences, University of Birmingham, City Hospital, Birmingham, United Kingdom.
authors: Gregory Y H
authors: GY
authors: Lip
authors: Centre for Cardiovascular Sciences, University of Birmingham, City Hospital, Birmingham, United Kingdom.
authors: Deirdre A
authors: DA
authors: Lane
authors: Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
authors: Lars Hvilsted
authors: LH
authors: Rasmussen
authors: Clinical Nursing Research Unit, Aalborg University Hospital Science and Innovation Center, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
authors: Erik Elgaard
authors: EE
authors: Sørensen
authors: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
authors: Torben Bjerregaard
authors: TB
authors: Larsen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: Adolescent; Anxiety Disorders; Depression; Psychotropic Drugs; Venous Thromboembolism; Young Adults