title: Association of erythropoietin gene polymorphisms with retinopathy in a Chinese cohort with type 2 diabetes mellitus.
abstract: BACKGROUND
  This study was performed to investigate the correlation of erythropoietin gene polymorphisms with diabetic retinopathy (DR) in a Chinese cohort with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Case-control study held in Qilu hospital of Shandong University, China.
  
  
  METHODS
  792 T2DM individuals were involved, classified as groups DR (n = 448) and non-DR (NDR; n = 344). The DR group was subdivided into groups proliferative DR (PDR; n = 220) and non-PDR (NPDR; n = 228).
  
  
  METHODS
  Three single-nucleotide polymorphisms, rs1617640, rs507392 and rs551238, in the erythropoietin gene were genotyped
  
  
  METHODS
  Odds ratios (ORs) for the effects of erythropoietin gene polymorphisms on DR risk.
  
  
  RESULTS
  The genotype CC frequency in rs507392 was significantly lower in DR group (additive: OR, 0.45; 95% confidence interval [CI], 0.23-0.89; P = 0.027; recessive: OR, 0.44; 95%CI, 0.23-0.86; P = 0.012) or PDR group (additive OR, 0.18; 95%CI, 0.05-0.63; P = 0.002; recessive OR, 0.19; 95%CI, 0.06-0.66; P = 0.003) than in NDR group. The genotype CC frequency in rs551238 was significantly lower in DR group (additive OR, 0.42; 95%CI, 0.21-0.38; P = 0.016; recessive OR, 0.40; 95%CI, 0.20-0.79; P = 0.010) or PDR group (additive OR, 0.18; 95%CI, 0.05-0.62; P = 0.002; recessive OR, 0.18; 95%CI, 0.05-0.61; P = 0.002). No significant differences were detected in the distributions of rs1617640 genotype or all polymorphisms' alleles between groups NDR and DR, PDR or NPDR. Haplotype analyses did not provide any evidence for the correlation between the three polymorphisms and DR.
  
  
  CONCLUSIONS
  Our data suggest that rs507392 and rs551238 in the erythropoietin gene probably act to lessen the risk for DR and PDR in the Chinese T2DM cohort.
authors: Operating Room, Qilu Hospital of Shandong University, Jinan, China.
authors: Qi
authors: Q
authors: Song
authors: Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, China.
authors: Yue
authors: Y
authors: Zhang
authors: State Key Lab of Crystal Materials, Shandong University, Jinan, China.
authors: Yongzhong
authors: Y
authors: Wu
authors: Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, China.
authors: Fang
authors: F
authors: Zhou
authors: Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, China.
authors: Yi
authors: Y
authors: Qu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000235:genetics*; D004921:Erythropoietin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D001786:Blood Glucose; D004921:Erythropoietin; D006442:Glycated Hemoglobin; C554270:EPO protein, human; C517652:hemoglobin A1c protein, human
keywords: Chinese; erythropoietin; retinopathy; single-nucleotide polymorphism; type 2 diabetes mellitus