title: Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population.
abstract: Among the factors postulated to play a role in MS susceptibility, the role of vitamin D is outstanding. Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility. In current study, we recruited 113 MS patients and 122 healthy controls. TaqI (rs731236) and ApaI (rs7975232) genetic variations in these two groups were evaluated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. All genotype and allele frequencies in both variations showed association with the disease status. However, to find the definite connection between genetic variations in VDR gene and MS disease in a population of South East of Iran, more researches on gene structure and its function with regard to patients' conditions are required.
authors: Genetics Department, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran ; Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
authors: Mehrnaz
authors: 0000-0002-5982-2493
authors: M
authors: Narooie-Nejad
authors: Department of Biology, Sistan and Baluchestan University, Zahedan 98155-987, Iran.
authors: Maryam
authors: M
authors: Moossavi
authors: Department of Biology, Sistan and Baluchestan University, Zahedan 98155-987, Iran.
authors: Adam
authors: A
authors: Torkamanzehi
authors: Department of Neurology, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
authors: Ali
authors: A
authors: Moghtaderi
mesh_terms: D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol