title: Morphological characteristics in peritoneum in patients with neutral peritoneal dialysis solution.
abstract: Peritoneal dialysis solution (PDS) plays a role in functional and morphological damage to the peritoneum. This study aimed to clarify the effect of neutral PDS in preventing morphological changes by assessing peritoneal damage and comparing morphological alterations between PD patients treated with neutral PDS and acidic PDS. Sixty-one patients participated from seven hospitals. All patients were treated with neutral PDS excluding icodextrin, during their entire PD treatment, and experienced no episode of peritonitis. The thickness of submesothelial compact (SMC) zone and the presence of vasculopathy in the anterior parietal abdominal peritoneum were assessed. The impact of icodextrin, hybrid therapy, and peritoneal rest and lavage in morphological alterations were determined. There was no significant difference in the average SMC thickness between neutral and acidic PDS. The vessel patency in patients using neutral PDS was significantly higher compared to that in acidic PDS at any time during PD. There were no significant suppressive effects from interventions or use of icodextrin with respect to peritoneal morphological injury. A monolayer of mesothelial cell was observed in approximately half the patients, especially in their receiving lavage patients. Neutral PDS, accompanied by other preventive approaches against peritoneal injury, might suppress the development of peritoneal morphological alterations.
authors: Division of Nephrology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan, chieko@juntendo.ac.jp.
authors: Chieko
authors: C
authors: Hamada
authors: Kazuho
authors: K
authors: Honda
authors: Kunio
authors: K
authors: Kawanishi
authors: Hirotaka
authors: H
authors: Nakamoto
authors: Yasuhiko
authors: Y
authors: Ito
authors: Tsutomu
authors: T
authors: Sakurada
authors: Yudo
authors: Y
authors: Tanno
authors: Toru
authors: T
authors: Mizumasa
authors: Masanobu
authors: M
authors: Miyazaki
authors: Misaki
authors: M
authors: Moriishi
authors: Masaaki
authors: M
authors: Nakayama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects; D005260:Female; D005936:Glucans / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D000077607:Icodextrin; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000187:drug effects* / Q000473:pathology*; D051436:Renal Insufficiency, Chronic / Q000473:pathology* / Q000628:therapy*; D055815:Young Adult
chemical_list: D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D005947:Glucose