title: Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy.
abstract: In this study we report semimetal nanomaterials of antimony (Sb) as highly efficient agent for photoacoustic imaging (PAI) and photothermal therapy (PTT). The Sb nanorod bundles have been synthesized through a facile route by mixing 1-octadecane (ODE) and oleyl amine (OAm) as the solvent. The aqueous dispersion of PEGylated Sb NPs, due to its broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, is applicable as a photothermal agent driven by 808 nm laser with photothermal conversion efficiency up to 41%, noticeably higher than most of the PTT agents reported before. Our in vitro experiments also showed that cancer cell ablation effect of PEGylated Sb NPs was dependent on laser power. By intratumoral administration of PEGylated Sb NPs, 100% tumor ablation can be realized by using NIR laser irradiation with a lower power of 1 W/cm(2) for 5 min (or 0.5 W/cm(2) for 10 min) and no obvious toxic side effect is identified after photothermal treatment. Moreover, intense PA signal was also observed after intratumoral injection of PEGylated Sb NPs and NIR laser irradiation due to their strong NIR photoabsorption, suggesting PEGylated Sb NPs as a potential NIR PA agent. Based on the findings of this work, further development of using other semimetal nanocrystals as highly efficient NIR agents can be achieved for vivo tumor imaging and PTT.
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: wwli@sjtu.edu.cn.
authors: Wanwan
authors: W
authors: Li
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA; State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan 410083, China; Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors: Pengfei
authors: P
authors: Rong
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA; School of Radiation Medicine and Protection (SRMP) and School of Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu 215123, China.
authors: Kai
authors: K
authors: Yang
authors: Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors: Peng
authors: P
authors: Huang
authors: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors: Kang
authors: K
authors: Sun
authors: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: shawn.chen@nih.gov.
authors: Xiaoyuan
authors: X
authors: Chen
mesh_terms: D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging; D006979:Hyperthermia, Induced; D008819:Mice, Nude; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D061088:Photoacoustic Techniques; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D019265:Spectroscopy, Near-Infrared; D014961:X-Ray Diffraction
chemical_list: D011092:Polyethylene Glycols; D000965:Antimony
keywords: Antimony; Nanorod bundles; Photoacoustic imaging (PAI); Photothermal therapy (PTT); Semimetal