title: Long-term prognosis of idiopathic nephrotic syndrome in children.
abstract: BACKGROUND
  To investigate the demographic, clinical and laboratory data of the children with idiopathic nephrotic syndrome (INS), and to determine prognostic factors that affect the clinical outcome of the patients.
  
  
  METHODS
  Medical charts of 372 patients diagnosed to have INS and followed up at least 5 years between January 1990 and December 2008 were evaluated, respectively. After initial demographic, clinical and laboratory findings of the patients were documented, therapeutic protocols, prognosis and prognostic factors were investigated.
  
  
  RESULTS
  299 of the patients (80.4%) were steroid responsive and 73 (19.6%) were not. Focal segmental glomerulosclerosis (FSGS) was observed in 57%, minimal change disease (MCD) in 20.6% and diffuse mesengial proliferation in 21.9% renal biopsy materials. Steroid sensitivity was higher in patients with MCD and under the age of five years. Resistance to steroids was higher in children with FSGS. Complete remission was achieved in 96% of patients who were sensitive to steroids and in 46.6% who were resistant. 15% of patients who were steroid resistant developed chronic kidney disease (CKD).
  
  
  CONCLUSIONS
  Intercurrent infections and response to steroid therapy are the most important factors affecting the prognosis of the disease.
authors: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital , Ankara , Turkey and.
authors: Sare Gülfem
authors: SG
authors: Özlü
authors: Gülay
authors: G
authors: Demircin
authors: Nazan
authors: N
authors: Tökmeci
authors: Aysun
authors: A
authors: Çaltık Yılmaz
authors: Özlem
authors: Ö
authors: Aydoğ
authors: Mehmet
authors: M
authors: Bülbül
authors: Ayşe
authors: A
authors: Öner
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone
keywords: Children; nephrotic syndrome; prognosis; steroid resistance; steroid sensitive