title: Impact of an endurance training program on exercise-induced cardiac biomarker release.
abstract: We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3-4 days/wk, 120-240 min/wk, 65-85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP.
authors: Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain; alegaz@unizar.es.
authors: Alejandro
authors: A
authors: Legaz-Arrese
authors: Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain;
authors: Isaac
authors: I
authors: López-Laval
authors: Resarch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom;
authors: Keith
authors: K
authors: George
authors: Lozano Blesa University Hospital, Zaragoza, Spain;
authors: Juan José
authors: JJ
authors: Puente-Lanzarote
authors: Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain;
authors: Carmen
authors: C
authors: Mayolas-Pi
authors: Section of Physical Education and Sports, University of Zaragoza, Zaragoza, Spain;
authors: Enrique
authors: E
authors: Serrano-Ostáriz
authors: Lozano Blesa University Hospital, Zaragoza, Spain;
authors: Pablo
authors: P
authors: Revilla-Martí
authors: Department of Education, University Jaume I, Castellón, Spain; and.
authors: Diego
authors: D
authors: Moliner-Urdiales
authors: Research Group Human Movement, University of Lleida, LLeida, Spain.
authors: Joaquín
authors: J
authors: Reverter-Masià
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D055070:Resistance Training; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: NH2-terminal pro-brain natriuretic peptide; endurance training; exercise; high-sensitivity cardiac troponin T