title: Renal angiomyolipoma: preoperative identification of atypical fat-poor AML.
abstract: The preoperative distinction between benign and malignant renal masses is a well-known radiographic diagnostic challenge. With angiomyolipoma (AML) and renal cell carcinoma (RCC) representing the most common benign and malignant renal parenchymal lesions, respectively, differentiating these two entities is especially important due to their vastly different treatments and prognoses. Renal AML is typically composed of smooth muscle cells, dysmorphic blood vessels, and varying amounts of adipose tissue. In most cases, "typical" AML can be diagnosed by identifying macroscopic fat with ultrasound, computed tomography, or magnetic resonance imaging. However, approximately 4-5 % of AML tumors have fat that is grossly undetectable by conventional techniques, precluding a straightforward diagnosis. The overlapping radiographic features between "atypical" or "fat-poor" AML and RCC, especially in smaller (<3-4 cm) lesions, lead many patients with benign AML to undergo unnecessary surgery for suspected RCC when the diagnosis is not established beforehand. This review presents the most recent studies and developments in preoperative evaluation of fat-poor AML.
authors: Grand Rapids Medical Education Partners, 1000 Monroe Avenue NE, Grand Rapids, MI, 49503, USA, reachcrystalfarrell@gmail.com.
authors: Crystal
authors: C
authors: Farrell
authors: Sabrina L
authors: SL
authors: Noyes
authors: Mouafak
authors: M
authors: Tourojman
authors: Brian R
authors: BR
authors: Lane
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D018207:Angiomyolipoma / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography