title: lincRNA HOTAIR as a novel promoter of cancer progression.
abstract: Large intergenic non-coding RNAs (lincRNA) regulate development and diseaseviainteractions with their protein partners. Expression of the lincRNA HOX transcript antisense RNA (HOTAIR) is elevated in a variety of malignancies and linked to metastasis and poor prognosis. HOTAIR promotes proliferation, invasion, and metastasis in the preclinical studies of cancer through modulation of chromatin modifying complexes. In the current review we discuss the molecular mechanisms of HOTAIR-mediated aggressive phenotypes of cancer, HOTAIR's potential in cancer intervention, and challenges in exploration of HOTAIR in cancer biology.
authors: Providence Regional Cancer Center, 105 W. 8th Avenue, Spokane, WA 99204 USA.
authors: Gregory
authors: G
authors: Loewen
authors: Medical Oncology Associates, 6001 North Mayfair Street, Spokane, WA 99208 USA.
authors: Ying
authors: Y
authors: Zhuo
authors: Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
authors: Yan
authors: Y
authors: Zhuang
authors: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, LA 70118 USA.
authors: Janarthanan
authors: J
authors: Jayawickramarajah
authors: College of Medical Sciences, Washington State University Spokane, 412 E. Spokane Falls Boulevard, Spokane, WA 99202 USA.
authors: Bin
authors: B
authors: Shan
keywords: EZH2; PRC2; cancer; lincRNA; metastasis