title: Efficient synthesis of (P-chirogenic) o-boronated phosphines from sec-phosphine boranes.
abstract: An efficient synthesis of boronated phosphines with an o-phenylene-bridge prepared from sec-phosphine boranes and using benzyne chemistry is reported. Successive reactions of sec-phosphine boranes with n-BuLi and 1,2-dibromobenzene, and then with boron reagents, afford the o-boronatophenylphosphine derivatives in 71% yields. The use of P-chirogenic sec-phosphine boranes leads to the free boronated phosphines with retention of configuration at the P-center after decomplexation. The reaction of P-chirogenic o-boronatophenylphosphine with KHF2 affords the corresponding trifluoroborated phosphine with ee >98%.
authors: Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB-StéréochIM) UMR CNRS 6302, 9 Avenue Alain Savary, BP 47870 , 21078 Dijon cedex, France.
authors: Jérôme
authors: J
authors: Bayardon
authors: Julie
authors: J
authors: Bernard
authors: Emmanuelle
authors: E
authors: Rémond
authors: Yoann
authors: Y
authors: Rousselin
authors: Raluca
authors: R
authors: Malacea-Kabbara
authors: Sylvain
authors: S
authors: Jugé