title: Adult cortical plasticity studied with chronically implanted electrode arrays.
abstract: The functional architecture of adult cerebral cortex retains a capacity for experience-dependent change. This is seen after focal binocular lesions as rapid changes in receptive field (RF) of the lesion projection zone (LPZ) in the primary visual cortex (V1). To study the dynamics of the circuitry underlying these changes longitudinally, we implanted microelectrode arrays in macaque (Macaca mulatta) V1, eliminating the possibility of sampling bias, which was a concern in previous studies. With this method, we observed a rapid initial recovery in the LPZ and, during the following weeks, 63-89% of the sites in the LPZ showed recovery of visual responses with significant position tuning. The RFs shifted ∼3° away from the scotoma. In the absence of a lesion, visual stimulation surrounding an artificial scotoma did not elicit visual responses, suggesting that the postlesion RF shifts resulted from cortical reorganization. Interestingly, although both spikes and LFPs gave consistent prelesion position tuning, only spikes reflected the postlesion remapping.
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and.
authors: Hiroshi
authors: H
authors: Abe
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and.
authors: Justin N J
authors: JN
authors: McManus
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and.
authors: Nirmala
authors: N
authors: Ramalingam
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
authors: Wu
authors: W
authors: Li
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and.
authors: Sally A
authors: http://orcid.org/0000-0002-1247-6001
authors: SA
authors: Marik
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and.
authors: Stephan Meyer Zum Alten
authors: SM
authors: Borgloh
authors: The Rockefeller University, 1230 York Avenue, New York, New York 10065, and gilbert@rockefeller.edu.
authors: Charles D
authors: CD
authors: Gilbert
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D008253:Macaca mulatta; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology; D012607:Scotoma / Q000503:physiopathology; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology
keywords: cortical plasticity; experience-dependent plasticity; primary visual cortex; retinal lesions; topographic remapping