title: A new proline-containing flavonol glycoside from Caragana leucophloea Pojark.
abstract: One new proline-containing flavonol glycoside, namely kaempferol-3-O-methyl-7-O-β-D-glucopyranosyl-8-(1-methyleneproline)-4'-O-β-D-glucopyranoside (1), together with 15 known flavonoids, 3-O-methylkaempferol (2), 3-O-methylquercetin (3), quercetin (4), kaempferol (5), apigenin (6), rhamnazin (7), astragalin (8), alquds (9), quercitrin (10), rutin (11), isoquercitrin (12), apigetrin (13), myricitrin (14), hesperidin (15) and calycosin-7-O-β-D-glucopyranoside (16) were isolated from the aerial parts of Caragana leucophloea Pojark. (Leguminosae). Their structures were determined on the basis of spectroscopic analyses and by comparison with literature data. Compounds 2-4 revealed a strong antimicrobial activity with minimum inhibitory concentration values of 12.5-150 μg/mL and median inhibitory concentration (IC50) values of 7.42-76.61 μg/mL. Compounds 3, 4, 6-8, 10-12 and 14 showed strong antioxidant activity. Compounds 2-7 exhibited moderate antinematodal activity on Caenorhabditis elegans with IC50 values of 40.51-68.05 μg/mL.
authors: a College of Agronomy and Biotechnology, China Agricultural University , Beijing 100193 , P.R. China.
authors: Chao
authors: C
authors: Luo
authors: Ali
authors: A
authors: Wang
authors: Xiaohan
authors: X
authors: Wang
authors: Jing
authors: J
authors: Li
authors: Hongwei
authors: H
authors: Liu
authors: Mingan
authors: M
authors: Wang
authors: Lan
authors: L
authors: Wang
authors: Daowan
authors: D
authors: Lai
authors: Ligang
authors: L
authors: Zhou
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D017173:Caenorhabditis elegans / Q000187:drug effects; D032602:Caragana / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D011392:Proline / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D044948:Flavonols; D006027:Glycosides; D011392:Proline
keywords: Caragana leucophloea Pojark; Leguminosae; biological activities; flavonoids; kaempferol-3-O-methyl-7-O-β-d-glucopyranosyl-8-(1-methyleneproline)-4′-O-β-d-glucopyranoside