title: A Fully Implantable Stimulator With Wireless Power and Data Transmission for Experimental Investigation of Epidural Spinal Cord Stimulation.
abstract: Epidural spinal cord stimulation (ESCS) combined with partial weight-bearing therapy (PWBT) has been shown to facilitate recovery of functional walking for individuals after spinal cord injury (SCI). The investigation of neural mechanisms of recovery from SCI under this treatment has been conducted broadly in rodent models, yet a suitable ESCS system is still unavailable. This paper describes a practical, programmable, and fully implantable stimulator for laboratory research on rats to explore fundamental neurophysiological principles for functional recovery after SCI. The ESCS system is composed of a personal digital assistant (PDA), an external controller, an implantable pulse generator (IPG), lead extension, and stimulating electrodes. The stimulation parameters can be programmed and adjusted through a graphical user interface on the PDA. The external controller is placed on the rat back and communicates with the PDA via radio-frequency (RF) telemetry. An RF carrier from the class-E power amplifier in the external controller provides both data and power for the IPG through an inductive link. The IPG is built around a microcontroller unit to generate voltage-regulated pulses delivered to the bipolar electrode for ESCS in rats. The encapsulated IPG measures 22 mm × 23 mm × 7 mm with a mass of  ∼  3.78 g. This fully implantable batteryless stimulator provided a simplified and efficient method to carry out chronic experiments in untethered animals for medical electro-neurological research.
authors: Qi
authors: Q
authors: Xu
authors: Dingyin
authors: D
authors: Hu
authors: Bingyu
authors: B
authors: Duan
authors: Jiping
authors: J
authors: He
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D004576:Electromyography; D004824:Epidural Space; D018482:Muscle, Skeletal / Q000502:physiology; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods; D011846:Radio Waves; D051381:Rats; D062187:Spinal Cord Stimulation / Q000295:instrumentation* / Q000379:methods*; D013686:Telemetry; D059015:Wireless Technology