title: Association Between High Serum Soluble Corin and Hypertension: A Cross-Sectional Study in a General Population of China.
abstract: BACKGROUND
  Corin has been suggested to be associated with hypertension by cell- and animal-based studies. However, the association still lacks population-based evidence which critically promotes translation from basic research to clinical and preventive practice. Here, we aimed to explore the association in a general population of China.
  
  
  METHODS
  From January to May 2010, we conducted a cross-sectional study in 2,498 participants aged above 30 years, residing in Gusu district of Suzhou. Serum soluble corin and blood pressure were measured.
  
  
  RESULTS
  Hypertensive participants had a higher level of serum corin than nonhypertensive participants (median (interquartile range): 1,836.83 (1,497.85-2,327.87) pg/ml vs. 1,579.14 (1,322.18-1,956.82) pg/ml, P < 0.001). Higher serum corin was positively associated with prevalent hypertension (odds ratio (OR) = 2.01, P < 0.001). In the multiple analysis, participants in the third (OR = 1.43, P = 0.007) and fourth (OR = 1.96, P < 0.001) quartiles had significantly increased odds of hypertension compared to those in the lowest quartile of serum corin. ORs of hypertension positively and significantly increased with serum corin levels (P for trend <0.001). Further subgroup analysis showed that ORs of hypertension associated with high corin (over the median level of serum corin: 1,689.20 pg/ml) were still significant in subgroups by age, body mass index, total cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose (all P < 0.05).
  
  
  CONCLUSIONS
  Our study showed that hypertensive participants had an increased serum corin level compared to those without hypertension. This ﬁnding suggests that corin may play a role in the pathology of hypertension.
authors: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China;
authors: Hao
authors: H
authors: Peng
authors: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China; Center for Disease Prevention and Control of Gusu District, Suzhou, China;
authors: Qiu
authors: Q
authors: Zhang
authors: Department of Diagnostic Center, the Kunshan Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Suzhou, China;
authors: Xiaoqin
authors: X
authors: Cai
authors: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China;
authors: Yan
authors: Y
authors: Liu
authors: Suzhou Entry-Exit Inspection and Quarantine Bureau, Suzhou, China.
authors: Jiansong
authors: J
authors: Ding
authors: Center for Disease Prevention and Control of Gusu District, Suzhou, China;
authors: Honggang
authors: H
authors: Tian
authors: Center for Disease Prevention and Control of Gusu District, Suzhou, China;
authors: Xiangqin
authors: X
authors: Chao
authors: Department of Diagnostic Center, the Kunshan Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Suzhou, China;
authors: Hengshan
authors: H
authors: Shen
authors: Center for Disease Prevention and Control of Gusu District, Suzhou, China;
authors: Li
authors: L
authors: Jiang
authors: Center for Disease Prevention and Control of Gusu District, Suzhou, China;
authors: Jianhua
authors: J
authors: Jin
authors: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China; yhzhang@suda.edu.cn.
authors: Yonghong
authors: Y
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: blood pressure; corin; hypertension; risk factors