title: Effect of bisphenol A on Drosophila melanogaster behavior--a new model for the studies on neurodevelopmental disorders.
abstract: Developmental disorders such as autism and attention deficit hyperactivity disorder (ADHD) appear to have a complex etiology implicating both genetic and environmental factors. Bisphenol A (BPA), a widely used chemical in the plastic containers and in the linings of food and beverage cans, has been suggested to play a possible causative role in some developmental disorders. Here, we report behavioral modifications in Drosophila melanogaster following early exposure to BPA, which may suggest BPA as an environmental risk factor for the behavioral impairments that are the basis of diagnosis of autism and ADHD. In an open field assay with perinatally BPA-exposed and vehicle-treated control Drosophila, different parameters of locomotion (distance traveled, walking speed, spatial movement, mobility, turn angle, angular velocity and meander) were analyzed using the ethovision software. We also examined the repetitive and social interaction behaviors in these flies. In an open field assay, we identified disturbances in the locomotion patterns of BPA-exposed Drosophila that may relate to the decision-making and the motivational state of the animal. An increase in repetitive behavior was observed as an increase in the grooming behavior of Drosophila following BPA exposure. Furthermore, we also observed abnormal social interaction by the BPA-exposed flies in a social setting. These results demonstrate the effect of the environmentally prevalent risk agent BPA on the behavior of Drosophila, and suggest the practicability and the ease of using Drosophila as a model in the studies of neurobehavioral developmental disorders.
authors: Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA; Biology/Neuroscience Graduate Program, City University of New York - Graduate Center, 365 5th Avenue, New York, NY 10016, USA; Center for Developmental Neuroscience and Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
authors: Kulbir
authors: K
authors: Kaur
authors: Department of Biology, Faculty of Science, Western Ontario University, Ontario, Canada.
authors: Anne F
authors: AF
authors: Simon
authors: Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
authors: Ved
authors: V
authors: Chauhan
authors: Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. Electronic address: abha.chauhan@opwdd.ny.gov.
authors: Abha
authors: A
authors: Chauhan
mesh_terms: D061725:Accelerometry; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D003657:Decision Making / Q000187:drug effects; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006120:Grooming / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009042:Motivation / Q000187:drug effects; D065886:Neurodevelopmental Disorders; D010636:Phenols / Q000633:toxicity*; D012919:Social Behavior; D012984:Software; D013239:Stereotyped Behavior / Q000187:drug effects; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Autism; Bisphenol A; Drosophila melanogaster; Grooming; Locomotion; Social interaction