title: Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting.
abstract: Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.
authors: Department of Chemistry, Korea University , Seoul 136-701, Korea.
authors: Hyo Sung
authors: HS
authors: Jung
authors: Jiyou
authors: J
authors: Han
authors: Jae-Hong
authors: JH
authors: Lee
authors: Ji Ha
authors: JH
authors: Lee
authors: Jong-Min
authors: JM
authors: Choi
authors: Hee-Seok
authors: HS
authors: Kweon
authors: Ji Hye
authors: JH
authors: Han
authors: Jong-Hoon
authors: JH
authors: Kim
authors: Kyung Min
authors: KM
authors: Byun
authors: Jong Hwa
authors: JH
authors: Jung
authors: Chulhun
authors: C
authors: Kang
authors: Jong Seung
authors: JS
authors: Kim
mesh_terms: D000818:Animals; D001692:Biological Transport; D002471:Cell Transformation, Neoplastic; D003374:Coumarins / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use*; D042541:Intracellular Space / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008928:Mitochondria / Q000378:metabolism*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000378:metabolism
chemical_list: D003374:Coumarins; D005290:Ferric Compounds; C000499:ferric oxide; C030123:coumarin