title: Forms of Circulating Luteinizing Hormone Human Chorionic Gonadotropin Receptor for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy.
abstract: OBJECTIVE
  To explore the value of circulating luteinizing human chorionic gonadotropin receptor (LHCGR) forms for the prediction of preeclampsia (PE) in the first trimester of pregnancy.
  
  
  METHODS
  Case-control study, based on a cohort of 5,759 pregnancies, including 20 early PE, 20 late PE, and 300 controls. We recorded/measured maternal characteristics, mean arterial pressure (MAP), uterine artery (UtA) Doppler, placental growth factor (PlGF), soluble Fms-like tyrosine kinase-1 (sFtl-1), and LHCGR forms (hCG-LHCGR and soluble LHCGR), and their independent predictive values were analyzed by logistic regression.
  
  
  RESULTS
  For early PE, the model included black ethnicity, chronic hypertension, previous PE, MAP, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, achieving detection rates (DR) of 83% at 10% of false-positive rates (FPR) [AUC: 0.961 (95% CI: 0.921-1)]. For late PE, the model included body mass index, previous PE, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, with DR of 75% at 10% of FPR [AUC: 0.923 (95% CI: 0.871-0.976)]. In both early and late PE, LHCGR forms improved DR by 6-15%.
  
  
  CONCLUSIONS
  LHCGR forms improved the prediction for early and late PE. These results should be confirmed in larger prospective studies.
authors: BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine, Hospital Clinic and Hospital Sant Joan de Deu, IDIBAPS, University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain.
authors: Francesca
authors: F
authors: Crovetto
authors: Francesc
authors: F
authors: Figueras
authors: Fatima
authors: F
authors: Crispi
authors: Stefania
authors: S
authors: Triunfo
authors: Michael
authors: M
authors: Pugia
authors: Luis
authors: L
authors: Lasalvia
authors: Anne E
authors: AE
authors: Chambers
authors: Walter E
authors: WE
authors: Mills
authors: Subhasis
authors: S
authors: Banerjee
authors: Imma
authors: I
authors: Mercadé
authors: Elena
authors: E
authors: Casals
authors: Aurea
authors: A
authors: Mira
authors: Laia
authors: L
authors: Rodriguez-Revenga Bodi
authors: Eduard
authors: E
authors: Gratacós
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D011974:Receptors, LH / Q000097:blood*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D011974:Receptors, LH