title: CD14+HLA-DRlow/-expression: A novel prognostic factor in chronic lymphocytic leukemia.
abstract: Currently, no prognostic factors exist for determining the host immune status of chronic lymphocytic leukemia (CLL) patients. Therefore, the present report analyzed cluster of differentiation 14 (CD14)+human leukocyte antigen (HLA)-DRlow/-myeloid-derived suppressor cells (MDSC) from 49 CLL patients and demonstrated that these cells were significantly expanded in all CLL patients when compared with monoclonal B cell lymphocytosis patients and healthy volunteers. Furthermore, upregulation of CD14+HLA-DRlow/-MDSCs was correlated with CLL tumor progression and a poor prognosis for CLL patients, and CD14+HLA-DRlow/-MDSCs were significantly correlated with the presence of CD4+T and CD5+CD19+cells in CLL patients, which could significantly inhibit the CD4+T-cell immune response, contributing to CLL cell progression in CLL patients.
authors: Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China.
authors: Jinlin
authors: J
authors: Liu
authors: Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China.
authors: Yonglie
authors: Y
authors: Zhou
authors: Department of Hematology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China.
authors: Qiang
authors: Q
authors: Huang
authors: Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310004, P.R. China.
authors: Liannv
authors: L
authors: Qiu
keywords: CD14+HLA-DRlow/−; chronic lymphocytic leukemia; prognostic factor