title: New developments in intracranial stereotactic radiotherapy for metastases.
abstract: Brain metastases are common and the prognosis for patients with multiple brain metastases treated with whole brain radiotherapy is limited. As systemic disease control continues to improve, the expectations of radiotherapy for brain metastases are growing. Stereotactic radiosurgery (SRS) as a high precision localised irradiation given in a single fraction prolongs survival in patients with a single brain metastasis and functional independence in those with up to three brain metastases. SRS technology has become commonplace and is available in many radiation oncology and neurosurgery departments. With increasing use there is a need for appropriate patient selection, refinement of dose-fractionation and safe integration of SRS with other treatment modalities. We review the evidence for current practice and new developments in the field, with a specific focus on patient-relevant outcomes.
authors: Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK; School of Medicine, University of Queensland, Brisbane, Australia.
authors: M B
authors: MB
authors: Pinkham
authors: Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK; The University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, UK.
authors: G A
authors: GA
authors: Whitfield
authors: University of Liverpool, Department of Clinical and Molecular Cancer Medicine and Academic Radiotherapy Unit, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, UK. Electronic address: michael.brada@liverpool.ac.uk.
authors: M
authors: M
authors: Brada
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D016371:Cranial Irradiation / Q000379:methods*; D006801:Humans; D009362:Neoplasm Metastasis; D016634:Radiosurgery / Q000379:methods*
keywords: Brain metastases; Gamma knife; Review; Stereotactic radiosurgery; Stereotactic radiotherapy