title: Assessment of cardiac troponin I (cTnI) and tissue velocity imaging (TVI) in 14 dogs with malignant lymphoma undergoing chemotherapy treatment with doxorubicin.
abstract: Doxorubicin has been shown to be cardiotoxic at high doses but is an efficacious chemotherapeutic agent in the treatment of canine lymphoma. Echocardiographic measurements and serum ultrasensitive cardiac troponin I (cTnI) levels were obtained before and after doxorubicin administration in 14 dogs diagnosed with lymphoma. The aim of this prospective study was to evaluate changes in cTnI concentrations and tissue velocity imaging (TVI) values in dogs with lymphoma undergoing chemotherapy with doxorubicin. A total of 182 cTnI and 1017 TVI measurements were performed. Standard echocardiographic parameters, tissue Doppler indices and cTnI concentrations did not differ at any time point within a 12-week cyclic combination protocol. In conclusion, the use of doxorubicin at standard doses in the treatment of canine lymphoma may not be associated with significant myocardial damage.
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: G
authors: G
authors: Tater
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: N
authors: N
authors: Eberle
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: S
authors: S
authors: Hungerbuehler
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: A
authors: A
authors: Joetzke
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: I
authors: I
authors: Nolte
authors: Clinic of Small Animal Internal Medicine, LMU-University, Munich, Germany.
authors: G
authors: G
authors: Wess
authors: Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany.
authors: D
authors: D
authors: Betz
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000009:adverse effects*; D004452:Echocardiography / Q000379:methods / Q000662:veterinary; D005260:Female; D006321:Heart / Q000187:drug effects*; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009206:Myocardium; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*
chemical_list: D000903:Antibiotics, Antineoplastic; D019210:Troponin I; D004317:Doxorubicin
keywords: biomarker; canine; cardiomyopathy; echocardiography; tissue Doppler