title: Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides.
abstract: BACKGROUND
  Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, is more common in patients aged 45-55.
  
  
  OBJECTIVE
  Cardiovascular risk factors have been investigated in several skin diseases. However, the relation between cardiovascular diseases and mycosis fungoides remains unclear. Therefore, the aim of this study was to assess cardiovascular risk factors in patients with mycosis fungoides.
  
  
  METHODS
  32 patients with mycosis fungoides and 26 healthy controls were enrolled in the study. Glucose, total cholesterol, high-density lipoprotein cholesterol, triglyceride, homocysteine, high sensitivity C-reactive protein, low-density lipoprotein-cholesterol, were measured in the sera of patients.
  
  
  RESULTS
  Patients had significantly higher high-sensitivity C-reactive protein, homocysteine, low-density lipoprotein-cholesterol, total cholesterol (p= 0.032) (p< 0.001) (p= 0.001) (p< 0.001). There was a positive correlation between the levels of homo-cysteine and total cholesterol (p= 0.001, r = +0.431). Additionally, a significantly positive correlation was found between the levels of high-sensitivity C-reactive protein and low-density lipoprotein-cholesterol (p= 0.014, r = +0.320) in patient group.
  
  
  CONCLUSIONS
  Patients with mycosis fungoides had significantly higher levels of total-cholesterol, low-density lipoprotein-cholesterol, homocysteine and high-sensitivity C-reactive protein than healthy subjects. The present study has demonstrated an increased rate of cardiovascular risk in patients with mycosis fungoides. Even though the etiology of these associations is elusive, dermatologists should be sensitized to investigate metabolic derangements in patients with mycosis fungoides, in order to lessen mortality and comorbidity with a multidisciplinary approach.
authors: Kars State Hospital, Kars, Turkey.
authors: Fatma Pelin
authors: FP
authors: Cengiz
authors: Kutahya Tavsanli State Hospital, Kutahya Tavsanli, Turkey.
authors: Nazan
authors: N
authors: Emiroglu
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000097:blood / Q000150:complications*; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol