title: New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities.
abstract: Two new sesquiterpenoid derivatives, attributable to eudesmane-type (1-2, named septemlobin D and 11,12-O-isopropylidenesolajiangxin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR ((1)H-(1)H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.0-7.3 μM.
authors: a School of Pharmaceutical Science, Yantai University , Yantai 264005 , P.R. China.
authors: Lei
authors: L
authors: Zhang
authors: Hai-Qing
authors: HQ
authors: Lin
authors: Gui-Sheng
authors: GS
authors: Li
authors: Xi-Dian
authors: XD
authors: Yue
authors: Sheng-Jun
authors: SJ
authors: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification; D032322:Solanum / Q000737:chemistry*
chemical_list: C000603291:11,12-O-isopropylidenesolajiangxin F; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D045787:Sesquiterpenes, Eudesmane; C000603290:septemlobin D; C015872:eudesmane
keywords: 11,12-O-isopropylidenesolajiangxin F; Solanaceae; Solanum septemlobum; cytotoxic activity; septemlobin D; sesquiterpenoid