title: Do mutational dynamics in stem cells explain the origin of common cancers?
abstract: For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.
authors: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: gcrossan@mrc-lmb.cam.ac.uk.
authors: Gerry P
authors: GP
authors: Crossan
authors: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
authors: Juan I
authors: JI
authors: Garaycoechea
authors: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: kjp@mrc-lmb.cam.ac.uk.
authors: Ketan J
authors: KJ
authors: Patel
mesh_terms: D002455:Cell Division / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D013234:Stem Cells / Q000502:physiology*