title: Body mass index (BMI) is associated with microalbuminuria in Chinese hypertensive patients.
abstract: There is no general consensus on possible factors associated with microalbuminuria in hypertensive patients nor any reported study about this issue in Chinese patients. To examine this issues, 944 hypertensive patients were enrolled in a study based on a cross-sectional survey conducted in Southern China. Multivariate regression analyses were performed to identify the factors related with the presence of microalbuminuria and urinary excretion of albumin. The prevalence of microalbuminuria in hypertensive and non-diabetic hypertensive patients were 17.16% and 15.25%, respectively. Body mass index (BMI), but not waist circumference (WC), were independently associated with microalbuminuria and the values of urinary albumin to creatinine ratio (ACR) based on multiple regression analyses, even after excluding diabetic patients and patients taking inhibitors of the renin-angiotensin system from the analyses. Furthermore, patients with obesity (BMI ≥28) had higher levels of ACR, compared with those with normal weight (BMI <24 kg/m²) and overweight (24 kg/m²≤ BMI < 28). In conclusion, BMI, as a modifiable factor, is closely associated with microalbuminuria among Chinese hypertensive patients, which may provide a basis for future development of intervention approaches for these patients.
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. xinyuliu2014@hotmail.com.
authors: Xinyu
authors: X
authors: Liu
authors: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China. mzmxly81@163.com.|Department of Statistics, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China. mzmxly81@163.com.
authors: Yu
authors: Y
authors: Liu
authors: Clinical Laboratory Centre, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. cym38432@163.com.
authors: Youming
authors: Y
authors: Chen
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. pepsi84@163.com.
authors: Yongqiang
authors: Y
authors: Li
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. shaoxfei@126.com.
authors: Xiaofei
authors: X
authors: Shao
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. pepsi84@163.com.
authors: Yan
authors: Y
authors: Liang
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. libin2014@163.com.
authors: Bin
authors: B
authors: Li
authors: Centre for Bio Analytical Sciences (CBAS), Dublin City University, Dublin 9, Ireland. harry.holthofer@dcu.ie.
authors: Harry
authors: H
authors: Holthöfer
authors: Techco Information Technologies Co., Ltd., Shenzhen 518057, China. john.zhang@e-techco.com.
authors: Guanjing
authors: G
authors: Zhang
authors: Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. hequnzou@hotmail.com.
authors: Hequn
authors: H
authors: Zou
mesh_terms: D000419:Albuminuria / Q000150:complications*; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence