title: Salidroside rescued mice from experimental sepsis through anti-inflammatory and anti-apoptosis effects.
abstract: BACKGROUND
  Salidroside (SDS) is the main effective component of Rhodiola rosea L with a variety of pharmacologic properties. The objective of this study was to investigate the efficacy of SDS in the treatment of experimental sepsis in mice and explore the possible underlying action mechanisms.
  
  
  METHODS
  Sepsis was induced in C57BL/6 male mice via cecal ligation and puncture (CLP). The animals were divided into three groups as follows: sham, CLP, and CLP plus SDS. SDS (50 mg/kg) was injected intraperitoneally 1 h after operation. Postoperative survival of the mice, bacterial clearance in blood and peritoneal lavage fluid, cytokine secretion in blood, and histology of lung were evaluated. In addition, apoptosis of immune cells in the spleen and thymus were examined, respectively.
  
  
  RESULTS
  SDS administration prolonged the survival of the septic mice, inhibited the proinflammatory responses, and enhanced bacterial clearance. It also alleviated the pathologic changes in the lung and inhibited the apoptosis of immune cells in the spleen and thymus after CLP challenge.
  
  
  CONCLUSIONS
  SDS exerts a protective effect in CLP-induced sepsis by attenuating the proinflammatory responses, enhancing bacterial clearance, and preserving adaptive immunity. SDS may be a promising therapeutic strategy for the treatment of sepsis.
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Anesthesiology, Chenggong Hospital, Xiamen University, Xiamen, China.
authors: Shanshan
authors: S
authors: Liu
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Anesthesiology, 285th Hospital of CPLA, Handan, China.
authors: Xiongwei
authors: X
authors: Yu
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
authors: Baoji
authors: B
authors: Hu
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: Yun
authors: Y
authors: Zou
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors: Jinbao
authors: J
authors: Li
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: nbastars@126.com.
authors: Lulong
authors: L
authors: Bo
authors: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: deng_x@yahoo.com.
authors: Xiaoming
authors: X
authors: Deng
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D004353:Drug Evaluation, Preclinical; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D029771:Rhodiola; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D016207:Cytokines; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C009172:rhodioloside
keywords: Apoptosis; Bacterial clearance; Experimental sepsis; Proinflammatory response; Traditional Chinese medicine