title: Use of surveillance data to identify target populations for Staphylococcus aureus vaccines and prevent surgical site infections: a pilot study.
abstract: The development of anti-staphylococcal vaccines is nowadays a priority to prevent surgical site infections (SSI). The objective of the present study was to identify a potential target population by assessing surveillance data on surgery patients for possible anti-staphylococcal vaccine administration. Individuals at high risk of SSI by Staphylococcus aureus (SA) were targeted by the French SSI Surveillance Network in south-eastern France between 2008 and 2011. Among 238,470 patients, those undergoing primary total hip replacement appeared to be an interesting and healthy enough population for anti-staphylococcal vaccine testing. These male patients, subjected to multiple procedures and with American Society of Anesthesiologists score>2, had a probability of SA SSI about 21 times higher than females with no severe systemic disease and no multiple procedures. Our study indicates that surveillance data on SSI might be an interesting epidemiological source for planning vaccine trials to prevent nosocomial infections.
authors: a Service d'Hygiène; Epidémiologie et Prévention; Hôpital Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
authors: Marie-Paule
authors: MP
authors: Gustin
authors: Marine
authors: M
authors: Giard
authors: Thomas
authors: T
authors: Bénet
authors: Philippe
authors: P
authors: Vanhems
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D013209:Staphylococcal Vaccines
keywords: ASA, American Society of Anesthesiologists; CI, confidence interval; OR, Odds ratio; SA, Staphylococcus aureus; SSI, surgical site infection; Staplylococcus aureus; orthopedic surgery; surgical site infection; surveillance; target population; vaccination