title: The influence of lung ischemia-reperfusion injury on myocardium.
abstract: OBJECTIVE
  To investigate the effect of lung Ischemia-reperfusion injury on cardiac muscle.
  
  
  METHODS
  SD rats were randomly divided into the following four groups: sham operation group (TS group); experimental control group (TG group); curcumin group (TC group); dexamethasone group (TM group). After 4 h and 24 h of lung ischemia-reperfusion, the cardiac muscle was collected. We measured the concentrations of TNF-α, IL-6, caspase-3, antioxidant capacity and neutrophil infiltration in myocardial tissue.
  
  
  RESULTS
  After lung ischemia-reperfusion 4 h, TNF-α, IL-6 levels, MDA and neutriphils infiltration increased in myocardial tissue in control group, total antioxidant capacity decreased, and caspase-3 exhibited no significant changes. However, 24 h after reperfusion, there were no significant difference between the sham group and experimental group.
  
  
  CONCLUSIONS
  Lung ischemia-reperfusion injury affected the function of cardiac muscle, especially 4 h after reperfusion. Curcumin and dexamethasone effectively protected myocardial injury after lung ischemia-reperfusion.
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Meng
authors: M
authors: Shi
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Jiechun
authors: J
authors: Huang
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Liewen
authors: L
authors: Pang
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Xiaotian
authors: X
authors: Sun
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Xianglin
authors: X
authors: Chu
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Rongrong
authors: R
authors: Jang
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Xiaolin
authors: X
authors: Xu
authors: Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
authors: Yiqing
authors: Y
authors: Wang
keywords: Lung ischemia; cardiac muscle; cytokines; neutrophil infiltration; oxidation