title: "One-drop-of-blood" electroanalysis of lead levels in blood using a foam-like mesoporous polymer of melamine-formaldehyde and disposable screen-printed electrodes.
abstract: A foam-like mesoporous polymer of melamine-formaldehyde (mPMF) was synthesized and further deposited on disposable screen-printed electrodes (SPEs) for the electroanalysis of Pb(2+) ions in blood. Investigations indicate that the prepared mPMF is ultrastable in water, showing a mesoporous structure and an amine-rich composition, as characterized by electronic microscopy images and IR spectra. Importantly, it possesses a highly-selective chelating ability and a powerful absorbent capacity for Pb(2+) ions. By way of solid-state PbCl2 voltammetry, the mPMF-modified sensor could allow for the detection of Pb(2+) ions in one drop of blood with a high detection selectivity, sensitivity (down to about 0.10 μg L(-1) Pb(2+) ions) and reproducibility. Such a simple "one-drop-of-blood" electroanalysis method equipped with disposable SPEs and a portable electrochemical transducer can be tailored for the field-deployable or on-site monitoring of blood Pb(2+) levels in the clinical laboratory.
authors: School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu City 273165, China. huawangqfnu@126.com.
authors: Yanfang
authors: Y
authors: Zhao
authors: Lubin
authors: L
authors: Xu
authors: Shuying
authors: S
authors: Li
authors: Qi
authors: Q
authors: Chen
authors: Daoshan
authors: D
authors: Yang
authors: Lingxin
authors: L
authors: Chen
authors: Hua
authors: H
authors: Wang
mesh_terms: D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D004785:Environmental Pollutants / Q000097:blood*; D006801:Humans; D007854:Lead / Q000097:blood*; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results; D014227:Triazines / Q000737:chemistry*
chemical_list: D004785:Environmental Pollutants; D011108:Polymers; D014227:Triazines; C504353:melamine formaldehyde; D007854:Lead