title: A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: A clinical study.
abstract: BACKGROUND
  This study was designed as a clinical trial to evaluate and compare the regenerative potential of platelet-rich fibrin (PRF), platelet-rich plasma (PRP), and blood clot in immature necrotic permanent teeth with or without associated apical periodontitis.
  
  
  METHODS
  Access preparation was done under rubber dam isolation. Copious irrigation was done with 2.5% NaOCl and triple antibiotic paste was placed as an intracanal medicament. After 4 weeks, the cases were divided into four groups with five patients in each group. The study design had three test arms and one control arm. Group I in which mineral trioxide aggregate apexification was carried out and it was kept as control group to evaluate the regenerative potential of blood clot and platelet concentrates, Group II in which blood clot was used as scaffold in the canal, Group III in PRF was used as scaffold, and Group IV in which PRP carried on collagen was used as a scaffold.
  
  
  RESULTS
  The clinical and radiographic evaluation after 6 and 18 months was done by two independent observers who were blinded from the groups. The scoring was done as: None score was denoted by, Fair by 1, Good by 2, and Excellent by 3. The data were then analyzed statistically by Fisher's exact test using Statistics and Data 11.1(PRP Using harvest Smart PReP2) which showed statistically significant values in Group III as compared to other Groups.
  
  
  CONCLUSIONS
  PRF has huge potential to accelerate the growth characteristics in immature necrotic permanent teeth as compared to PRP and blood clot.
authors: Department of Conservative Dentistry and Endodontics, BHU, Varanasi, Uttar Pradesh, India.
authors: Isha
authors: I
authors: Narang
authors: Department of Conservative Dentistry and Endodontics, BHU, Varanasi, Uttar Pradesh, India.
authors: Neelam
authors: N
authors: Mittal
authors: Department of Conservative Dentistry and Endodontics, BHU, Varanasi, Uttar Pradesh, India.
authors: Navin
authors: N
authors: Mishra
keywords: Blood clot; immature teeth; platelet-rich fibrin; platelet-rich plasma; scaffold