title: Heterogeneous platinum-catalyzed C-H perfluoroalkylation of arenes and heteroarenes.
abstract: Fluorinated organic compounds are gaining increasing interest for life science applications. The replacement of hydrogen in arenes or heteroarenes by a perfluoroalkyl group has a profound influence on the physical and biological properties of such building blocks. Here, an operationally simple protocol for the direct C-H perfluoroalkylation of (hetero)arenes with R(f)I or R(f)Br has been developed, using a robust supported platinum catalyst. The ready availability of the starting materials, the excellent substrate tolerance, and the reusability of the catalyst make this method attractive for the synthesis of a variety of perfluoroalkyl-substituted aromatic compounds. Preliminary mechanistic studies revealed the formation of radicals to be crucial in the reaction system.
authors: Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert-Einstein-Strasse 29a, 18059 Rostock (Germany).
authors: Lin
authors: L
authors: He
authors: Kishore
authors: K
authors: Natte
authors: Jabor
authors: J
authors: Rabeah
authors: Christoph
authors: C
authors: Taeschler
authors: Helfried
authors: H
authors: Neumann
authors: Angelika
authors: A
authors: Brückner
authors: Matthias
authors: M
authors: Beller
keywords: CH activation; heterogeneous catalysis; platinum; radicals; synthetic methods