title: Effect of standard interferon and ribavirin on haemoglobin level in hepatitis-C patients.
abstract: BACKGROUND
  The standard treatment for HCV infection involves combination therapy with pegylated interferon and ribavirin. The study was conducted to determine the effect of standard interferon and ribavirin on the haemoglobin level in patients treated for hepatitis-C.
  
  
  METHODS
  PCR confirmed 58 patients of chronic hepatitis-C treated with standard interferon and ribavirin for six months were included in this case series study. The patients were followed up monthly. Haemoglobin was measured by Sysmex Haematology analyser at monthly interval to study change in its level.
  
  
  RESULTS
  The study found decrease in the mean haemoglobin levels during the six months treatment. when the mean of baseline haemoglobin was compared with the mean haemoglobin of six months treatment, a decrease of 2.05 gm/dl was observed and the result was statistically significant (p=0.000).
  
  
  CONCLUSIONS
  Six months treatment of chronic hepatitis-C with standard interferon and ribavirin decreases haemoglobin to a significant level causing anaemia in susceptible patients.
authors: Jadoon
authors: J
authors: Shakeel Ahmad
authors: Ahmed
authors: A
authors: Ashfaa
authors: Jadoon
authors: J
authors: Habib Ahmad
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D006454:Hemoglobins; D016898:Interferon-alpha; D012254:Ribavirin