title: Asymmetric intramolecular aza-Michael reaction in desymmetrization processes. Total synthesis of hippodamine and epi-hippodamine.
abstract: The use of chiral sulfinyl amines both as nucleophilic nitrogen sources and chiral inducers has been described for the first time in a desymmetrization-type process involving an intramolecular aza-Michael reaction. The resulting product was employed as an advanced intermediate in the total synthesis of the natural product hippodamine and epi-hippodamine, taking advantage of the special symmetry of these molecules. In addition, this is the first asymmetric total synthesis of epi-hippodamine.
authors: Departamento de Química Orgánica, Universidad de Valencia , 46100 Burjassot, Spain.
authors: Marta
authors: M
authors: Guerola
authors: María
authors: M
authors: Sánchez-Roselló
authors: Cristina
authors: C
authors: Mulet
authors: Carlos
authors: C
authors: del Pozo
authors: Santos
authors: S
authors: Fustero