title: The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study.
abstract: OBJECTIVE
  Anaemia and iron deficiency are constituents of the cardio-renal syndrome in chronic heart failure (CHF). We investigated the effects of i.v. iron in iron-deficient CHF patients on renal function, and the efficacy and safety of this therapy in patients with renal dysfunction.
  
  
  RESULTS
  The FAIR-HF trial randomized 459 CHF patients with iron deficiency (ferritin <100 µg/L, or between 100 and 299 µg/L if transferrin saturation was <20%): 304 to i.v. ferric carboxymaltose (FCM) and 155 to placebo, and followed-up for 24 weeks. Renal function was assessed at baseline and at weeks 4, 12, and 24, using the estimated glomerular filtration rate (eGFR, mL/min/1.73 m(2) ), calculated from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. At baseline, renal function was similar between groups (62.4 ± 20.6 vs. 62.9 ± 23.4 mL/min/1.73 m(2) , FCM vs. placebo). Compared with placebo, treatment with FCM was associated with an increase in eGFR [treatment effect: week 4, 2.11 ± 1.21 (P = 0.082); week 12, 2.41 ± 1.33 (P = 0.070); and week 24, 2.98 ± 1.44 mL/min/1.73 m(2) (P = 0.039)]. This effect was seen in all pre-specified subgroups (P > 0.20 for interactions). No interaction between the favourable effects of FCM and baseline renal function was seen for the primary endpoints [improvement in Patient Global Assessment (P = 0.43) and NYHA class (P = 0.37) at 24 weeks]. Safety and adverse event profiles were similar in patients with baseline eGFR <60 and ≥60 mL/min/1.73 m(2) .
  
  
  CONCLUSIONS
  Treatment of iron deficiency in CHF patients with i.v. FCM was associated with an improvement in renal function. FCM therapy was effective and safe in CHF patients with renal dysfunction.
authors: Medical University, Wroclaw, Poland.
authors: Piotr
authors: P
authors: Ponikowski
authors: Gerasimos
authors: G
authors: Filippatos
authors: Josep Comin
authors: JC
authors: Colet
authors: Ronnie
authors: R
authors: Willenheimer
authors: Kenneth
authors: K
authors: Dickstein
authors: Thomas
authors: T
authors: Lüscher
authors: Giedrius
authors: G
authors: Gaudesius
authors: Barbara
authors: B
authors: von Eisenhart Rothe
authors: Claudio
authors: C
authors: Mori
authors: Nicola
authors: N
authors: Greenlaw
authors: Ian
authors: I
authors: Ford
authors: Iain
authors: I
authors: Macdougall
authors: Stefan D
authors: SD
authors: Anker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage*; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008320:Maltose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D005290:Ferric Compounds; C522335:ferric carboxymaltose; D008320:Maltose
keywords: Chronic heart failure; Ferric carboxymaltose; Iron deficiency; Renal function