title: The current challenges for pancreas transplantation for diabetes mellitus.
abstract: Pancreas transplantation is an accepted treatment for a subset of patients with diabetes mellitus, in particular those with renal failure who also require a kidney transplant and those with life-threatening hypoglycaemic unawareness. As results have improved and demand has risen, attention has focused on increasing the availability of pancreas transplantation by utilising pancreases from less than ideal donors, as well as addressing factors that limit the longevity of graft survival. The development of islet transplantation has posed additional demands on donor pancreas availability, as well as posing new challenges for donor organ allocation. This review focuses upon some of the current areas of interest in pancreatic transplantation.
authors: University of Cambridge, Department of Surgery, Box 202, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge CB2 0QQ, UK. Electronic address: cjew2@cam.ac.uk.
authors: Christopher J E
authors: CJ
authors: Watson
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation / Q000379:methods; D016035:Pancreas Transplantation / Q000379:methods*; D012008:Recurrence; D016896:Treatment Outcome
keywords: Cyclosporin (PubChem CID: 5284373); Diabetes mellitus; Everolimus (PubChem CID: 6442177); Mycophenolic acid (PubChem CID: 446541); Organ donation; Pancreas transplantation; Sirolimus (PubChem CID: 5284616); Tacrolimus (PubChem CID: 445643); Temsirolimus (PubChem CID: 6918289)