title: [Brain mechanisms of depression--preliminary evidence from fMRI studies].
abstract: Although brain monoamines serotonin, noradrenaline, and dopamine have been repeatedly shown to be linked to depression, it remains unclear how monoamine dysfunction is mechanistically related to symptoms of depression. We hypothesized that imbalances in the networks of regions innervated by monoamines disrupt patients' learning and decision-making abilities, and this disruption could, in turn, lead to symptoms of depression. We have conducted functional magnetic resonance imaging (fMRI) studies on learning and decision-making, mainly focusing on the role of serotonin. Our results suggest that parallel organization for reward prediction at different time scales in the striatum is under differential modulation by serotonin, and that depression is associated with a diminished recruitment of the dorsal striatum, involved in long-term reward prediction. Based on these findings, the brain mechanisms of depression are discussed.
authors: Go
authors: G
authors: Okada
authors: Yasumasa
authors: Y
authors: Okamoto
authors: Kazuhiro
authors: K
authors: Shishida
authors: Kazutaka
authors: K
authors: Ueda
authors: Keiichi
authors: K
authors: Onoda
authors: Yoshihiko
authors: Y
authors: Kunisato
authors: Saori C
authors: SC
authors: Tanaka
authors: Kenji
authors: K
authors: Doya
authors: Shigeto
authors: S
authors: Yamawaki
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001931:Brain Mapping; D003863:Depression / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012201:Reward; D012701:Serotonin / Q000378:metabolism
chemical_list: D012701:Serotonin