title: Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis.
abstract: Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient's survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosine), and management of elevated intracranial pressure based on the principles of traumatic brain injury.
authors: Pediatric Infectious Diseases Section and wlinam@uams.edu.
authors: W Matthew
authors: WM
authors: Linam
authors: Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and.
authors: Mubbasheer
authors: M
authors: Ahmed
authors: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Jennifer R
authors: JR
authors: Cope
authors: Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and.
authors: Craig
authors: C
authors: Chu
authors: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Govinda S
authors: GS
authors: Visvesvara
authors: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Alexandre J
authors: AJ
authors: da Silva
authors: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Yvonne
authors: Y
authors: Qvarnstrom
authors: Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and.
authors: Jerril
authors: J
authors: Green
mesh_terms: D000562:Amebiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D002555:Cerebrospinal Fluid / Q000469:parasitology; D002648:Child; D016054:DNA, Protozoan / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D016848:Naegleria fowleri / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D016054:DNA, Protozoan
keywords: Naegleria fowleri; hypothermia; miltefosine; primary amebic meningoencephalitis