title: Low-dose CT screening in an Asian population with diverse risk for lung cancer: A retrospective cohort study.
abstract: OBJECTIVE
  To evaluate the performance of low-dose CT (LDCT) screening for lung cancer (LCA) detection in an Asian population with diverse risks for LCA.
  
  
  METHODS
  LCA screening was performed in 12,427 symptomless Asian subjects using either LDCT (5,771) or chest radiography (CXR) (6,656) in a non-trial setting. Subjects were divided into high-risk and non-high-risk groups. Data were collected on the number of patients with screening-detected LCAs and their survival in order to compare outcomes between LDCT and CXR screening with the stratification of risks considering age, sex and smoking status.
  
  
  RESULTS
  In the non-high-risk group, a significant difference was observed for the detection of lung cancer (adjusted OR, 5.07; 95 % CI, 2.72-9.45) and survival (adjusted HR of LCA survival between LDCT vs. CXR group, 0.08; 95 % CI, 0.01-0.62). No difference in detection or survival of LCA was noticed in the high-risk group. LCAs in the non-high-risk group were predominantly adenocarcinomas (96 %), and more likely to be part-solid or non-solid compared with those in the high-risk group (p = 0.023).
  
  
  CONCLUSIONS
  In the non-high-risk group, LDCT helps detect more LCAs and offers better survival than CXR screening, due to better detection of part solid or non-solid lung adenocarcinomas.
  
  
  CONCLUSIONS
  • In an Asian non-high-risk group, LDCT helps detect more early-staged LCAs. • CT-detected lung cancers in non-high-risk subjects demonstrate better survival than CXR-detected cancers. • CT-detected lung cancers in non-high-risk subjects are predominantly part-solid or non-solid adenocarcinomas. • Mortality benefit of LDCT screening in non-high-risk subjects needs to be investigated.
authors: Department of Radiology and Center for Imaging Science, Sungkyunkwan University School of Medicine, Seoul, 135-710, Korea.
authors: Chin A
authors: CA
authors: Yi
authors: Kyung Soo
authors: KS
authors: Lee
authors: Myung-Hee
authors: MH
authors: Shin
authors: Yun Yung
authors: YY
authors: Cho
authors: Yoon-Ho
authors: YH
authors: Choi
authors: O Jung
authors: OJ
authors: Kwon
authors: Kyung Eun
authors: KE
authors: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D012189:Retrospective Studies; D012306:Risk; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult