title: Construction of a artificial glutathione peroxidase with temperature-dependent activity based on a supramolecular graft copolymer.
abstract: A supramolecular artificial glutathione peroxidase (PNIPAM-CD-g-Te) was prepared based on a supramolecular graft copolymer. PNIPAM-CD-g-Te was constructed by supramolecular host-guest self-assembly. Significantly, PNIPAM-CD-g-Te displayed noticeable temperature-dependent catalytic activity and typical saturation kinetics behavior. It was also proved that the change in the self-assembled structure of PNIPAM-CD-g-Te during the temperature-dependent process played a significant role in the temperature-dependent catalytic behavior. The construction of PNIPAM-CD-g-Te based on supramolecular graft copolymer endows artificial GPx with temperature-dependent catalytic ability, enriched catalytic centers, and homogeneously distributed catalytic centers. This work bodes well for the development of other biologically related host-guest supramolecular biomaterials.
authors: Guangxi Colleges and Universities Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization Qinzhou University, No.89, Xihuan Nanlu, Qinzhou 535000 (P.R. China). yinyanzhen2014@163.com.
authors: Yanzhen
authors: Y
authors: Yin
authors: Shufei
authors: S
authors: Jiao
authors: Yun
authors: Y
authors: Wang
authors: Ruirui
authors: R
authors: Zhang
authors: Zhongfeng
authors: Z
authors: Shi
authors: Xiaoxi
authors: X
authors: Hu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D002384:Catalysis; D003505:Cyclodextrins / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000737:chemistry*; D007700:Kinetics; D013691:Tellurium / Q000737:chemistry*; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D003505:Cyclodextrins; C052970:poly-N-isopropylacrylamide; D005979:Glutathione Peroxidase; D013691:Tellurium
keywords: artificial enzyme; biocatalyst; catalytic activity; self-assembly; supramolecular graft copolymer