title: Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae).
abstract: Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3H)-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds (1-4) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma.
authors: Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors: Gervais Mouthé
authors: GM
authors: Happi
authors: Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon. Electronic address: kfogue@yahoo.com.
authors: Simeon Fogue
authors: SF
authors: Kouam
authors: Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors: Ferdinand Mouafo
authors: FM
authors: Talontsi
authors: Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors: Sebastian
authors: S
authors: Zühlke
authors: Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors: Marc
authors: M
authors: Lamshöft
authors: Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
authors: Michael
authors: M
authors: Spiteller
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000962:Antimalarials; D014315:Triterpenes
keywords: Antiplasmodial; Cytotoxicity; Entandrophragma congoënse; Meliaceae; Triterpenoids