title: Dietary total antioxidant capacity and mortality in the PREDIMED study.
abstract: OBJECTIVE
  The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular disease risk.
  
  
  METHODS
  A total of 7,447 subjects from the PREDIMED study (multicenter, parallel group, randomized controlled clinical trial), were analyzed treating data as an observational cohort. Different antioxidant vitamin intake and total dietary antioxidant capacity were calculated from a validated 137-item food frequency questionnaire at baseline and updated yearly. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were fitted to assess the relationship between dietary total antioxidant capacity and mortality. Dietary total antioxidant capacity was estimated using ferric-reducing antioxidant power assays.
  
  
  RESULTS
  A total of 319 deaths were recorded after a median follow-up of 4.3 years. Subjects belonging to the upper quintile of antioxidant capacity were younger, ex-smokers, with high educational level, and more active and had higher alcohol intake. Multivariable-adjusted models revealed no statistically significant difference between total dietary antioxidant capacity and mortality (Q5 vs. Q1 ref HR 0.85; 95% CI 0.60-1.20) neither for the intake of all the vitamins studied.
  
  
  CONCLUSIONS
  No statistically significant association was found between antioxidant capacity and total mortality in elderly subjects at high cardiovascular risk.
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. patricia.henriquez@ulpgc.es.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. patricia.henriquez@ulpgc.es.
authors: P
authors: P
authors: Henríquez-Sánchez
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors: A
authors: A
authors: Sánchez-Villegas
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors: C
authors: C
authors: Ruano-Rodríguez
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Navarra, Spain.
authors: A
authors: A
authors: Gea
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Nutrition and Food Science Department, XaRTA, INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain.
authors: R M
authors: RM
authors: Lamuela-Raventós
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
authors: R
authors: R
authors: Estruch
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain.
authors: J
authors: J
authors: Salas-Salvadó
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos II, Madrid, Spain.|Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.
authors: M I
authors: MI
authors: Covas
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain.
authors: D
authors: D
authors: Corella
authors: CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.|Cardiovascular Risk and Nutrition Research Group, Institut Municipal d'Investigació Medica (IMIM)-Institut de Recerca del Hospital del Mar, Barcelona, Spain.
authors: H
authors: H
authors: Schröder
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Preventive Medicine, University of Malaga, Málaga, Spain.
authors: M
authors: M
authors: Gutiérrez-Bedmar
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Seville, Spain.
authors: J M
authors: JM
authors: Santos-Lozano
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
authors: X
authors: X
authors: Pintó
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Cardiology, University Hospital of Alava, Vitoria, Spain.
authors: F
authors: F
authors: Arós
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Institute of Health Sciences, University of Balearic Islands, Palma de Mallorca, Spain.|Hospital Son Espases, Palma de Mallorca, Spain.
authors: M
authors: M
authors: Fiol
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Nutrition and Food Science Department, XaRTA, INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain.
authors: A
authors: A
authors: Tresserra-Rimbau
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Spain.
authors: E
authors: E
authors: Ros
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Navarra, Spain.
authors: M A
authors: MA
authors: Martínez-González
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors: L
authors: L
authors: Serra-Majem
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000975:Antioxidants / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control; D038441:Diet, Mediterranean; D002149:Energy Intake; D005500:Follow-Up Studies; D019083:Mediterranean Region / Q000453:epidemiology; D009043:Motor Activity; D015999:Multivariate Analysis; D015596:Nutrition Assessment; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D014131:Trace Elements / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D014815:Vitamins
keywords: Antioxidant intake; Dietary antioxidant capacity; Mortality; PREDIMED