title: [Functional state of cardiovascular system by progressive absences--epilepsy and its treatment].
abstract: Age-dependent increase of seizure activity at absence epilepsy exacerbates hemodynamic and autonomic regulation of heart rate. Cardiac dysfunction is accompanied by an increasing duration of intervals repolarization left ventricular QTc, which causes the risk of life-threatening arrhythmias, increases the threat of sudden cardiac death. Anticonvulsant drug therapy provides an opportunity to improve the functional state of the cardiovascular system, if not exceeded a certain level of seizure activity of the brain. This possibility remains as long as the progressive seizure activity isn't reaches a certain level. Later anticonvulsant drug therapy reduces seizure activity of the brain, but does not improve the functional state of heart.
authors: M L
authors: ML
authors: Mamalyga
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004562:Electrocardiography; D004832:Epilepsy, Absence / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D051381:Rats; D017208:Rats, Wistar; D013686:Telemetry; D014635:Valproic Acid / Q000494:pharmacology*; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid