title: Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio.
abstract: BACKGROUND
  Obstructive sleep apnea syndrome (OSAS) is characterized by cyclic episodes of hypoxemia and reoxygenation. It has been suggested that OSAS is associated with chronic inflammation within the microvasculature. This low-grade inflammation may play a role in the pathophysiology of OSAS-related comorbidities. Evaluation of the inflammatory markers may predict the degree of the systemic inflammation and this may be a prognostic factor for future adverse events such as cardiovascular risks. Proinflammatory cytokines have been extensively studied in sleep-disordered breathing. Neutrophil-to-lymphocyte ratio is a recently described indicator of systemic inflammation, but it has not been studied in OSAS patients. In this study we aimed to evaluate the easily measurable parameters of systemic inflammation in these patients. We conducted this study to examine the association among OSAS and C- reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio.
  
  
  METHODS
  OSAS patients who underwent overnight polysomnography were studied retrospectively. They were divided into 4 groups: control, mild, moderate, and severe OSAS patients. Blood test results and inflammatory markers were compared between the groups. One-way ANOVA and Kruskall-Wallis H test were used for statistical analysis.
  
  
  RESULTS
  A total of 147 patients were included in the study. No differences in evaluated inflammatory markers were observed among the 4 groups.
  
  
  CONCLUSIONS
  Evaluation of the OSAS-related systemic inflammation is not likely to be possible by CRP, ESR, or neutrophil-to-lymphocyte ratio measurements. These markers do not seem to be associated with the degree of the upper airway obstruction.
authors: Department of Otorhinolaryngology Head and Neck Surgery, Ordu University Medical School, Ordu, Turkey.
authors: Mukadder
authors: M
authors: Korkmaz
authors: Department of Otorhinolaryngology Head and Neck Surgery, Ordu University Medical School, Ordu, Turkey.
authors: Hakan
authors: H
authors: Korkmaz
authors: Department of Pulmonary Diseases, Ordu State Hospital, Ordu, Turkey.
authors: Fatma
authors: F
authors: Küçüker
authors: Department of Biochemistry, Ordu University Medical School, Ordu, Turkey.
authors: Sema Nur
authors: SN
authors: Ayyıldız
authors: Department of Biostatistics, Ordu University Medical School, Ordu, Turkey.
authors: Soner
authors: S
authors: Çankaya
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D008214:Lymphocytes / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein