title: Canine multi-drug resistance-1 mutation prevalence: A South African perspective.
abstract: The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between geographical regions. This report provides prevalence data of the canine mdr-1 mutation in 306 South African dogs.
authors: Department of Paraclinical Sciences, University of Pretoria. lerica.leroux@up.ac.za.
authors: Lérica
authors: L
authors: le Roux-Pullen
authors: Henriëtte
authors: H
authors: van der Zwan
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D004285:Dogs; D005820:Genetic Testing / Q000662:veterinary*; D009154:Mutation; D020258:Neurotoxicity Syndromes / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D013019:South Africa / Q000453:epidemiology
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1