title: The effect of vitamin D supplementation on arterial stiffness in an elderly community-based population.
abstract: Vitamin D deficiency may lead to impaired vascular function and abnormalities in central arterial stiffness. We compared the effects of two different doses of vitamin D3 on arterial stiffness in an elderly population with deficient serum 25-hydroxy-vitamin D levels. A total of 119 known vitamin D deficient (<50 nmol/L) subjects were randomized to receive either 50,000 international units (IU) or 100,000 IU single intramuscular vitamin D3. In the group that received 100,000 IU vitamin D, median pulse wave velocity decreased from 12.2 m/s (range, 5.1-40.3 m/s) to 11.59 m/s (range, 4.3-14.9 m/s) after 8 weeks (P = .22). A mean decrease of 3.803 ± 1.7 (P = .032) in augmentation index (a measure of systemic stiffness) was noted. Only 3/51 (5.8%) who received 100,000 IU vitamin D reached levels of sufficiency (>75 nmol/L). A significant decrease in augmentation index was seen in the group that received 100,000 IU vitamin D. Serum levels of 25-hydroxy-vitamin D were still deficient at 8 weeks in the majority of patients, which may be attributable to impaired bioavailability.
authors: Department of Stroke and Geriatric Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. coramcgreevy@rcsi.ie.
authors: Cora
authors: C
authors: McGreevy
authors: Department of Stroke and Geriatric Medicine, Beaumont Hospital, Dublin, Ireland.
authors: Miriam
authors: M
authors: Barry
authors: Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
authors: Colin
authors: C
authors: Davenport
authors: Department of Chemical Pathology, Beaumont Hospital, Dublin, Ireland.
authors: Brendan
authors: B
authors: Byrne
authors: Department of Chemical Pathology, Beaumont Hospital, Dublin, Ireland.
authors: Caroline
authors: C
authors: Donaghy
authors: Department of Chemical Pathology, Beaumont Hospital, Dublin, Ireland.
authors: Geraldine
authors: G
authors: Collier
authors: Department of Chemical Pathology, Beaumont Hospital, Dublin, Ireland.
authors: William
authors: W
authors: Tormey
authors: Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
authors: Diarmuid
authors: D
authors: Smith
authors: Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James' Hospital, Dublin, Ireland.
authors: Kathleen
authors: K
authors: Bennett
authors: Department of Stroke and Geriatric Medicine, Beaumont Hospital, Dublin, Ireland.
authors: David
authors: D
authors: Williams
mesh_terms: D000368:Aged; D001682:Biological Availability; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D063177:Pulse Wave Analysis / Q000379:methods; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000187:drug effects*; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D014815:Vitamins / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Older patients; arterial stiffness; cholecalciferol; pulse wave velocity