title: Statin use and survival in elderly patients with endometrial cancer.
abstract: BACKGROUND
  Endometrial cancer is the most common gynecologic cancer in the United States. Statins have demonstrated anti-cancer effects in other tumor types, such as the breast and lung cancers.
  
  
  OBJECTIVE
  The objective of our study was to determine the association between statin use and endometrial cancer survival in a nationally-representative elderly population with endometrial cancer in the U.S.
  
  
  METHODS
  We employed the linked Surveillance, Epidemiology and End Results registries and Medicare claims files to collect data from 2987 patients who were diagnosed with endometrial cancer between 2007 and 2009 and who received a hysterectomy. The association between statin use and overall survival was examined using Cox regression models adjusting for follow-up time, age, race, neighborhood income, cancer stage, tumor grade, hysterectomy type, chemotherapy, radiation, impaired glucose tolerance, obesity, dyslipidemia and diabetes.
  
  
  RESULTS
  The mortality rate was lower in statin users compared to non-users for both type I (4.6 vs. 5.7 deaths/100 person-years, p=0.08) and type II (11.2 vs. 16.5 deaths/100 person-years, p=0.01) cancer types. However, after adjustment for the time from surgery to statin use and confounding, statin use after a hysterectomy was not significantly associated with a reduction in hazard of death for both type I (hazard ratio [HR] 0.92, 95%CI 0.70,1.2) and type II (HR=0.92, 95%CI 0.65, 1.29, p=0.62) endometrial cancer patients.
  
  
  CONCLUSIONS
  Accounting for all confounders and biases considered, statin use on or after a hysterectomy was not associated with survival in those with type I or type II disease.
authors: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States.
authors: Lara S
authors: LS
authors: Yoon
authors: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Samuel Oschin Cancer Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors: Marc T
authors: MT
authors: Goodman
authors: Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors: B J
authors: BJ
authors: Rimel
authors: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Samuel Oschin Cancer Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address: christie.jeon@cshs.org.
authors: Christie Y
authors: CY
authors: Jeon
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D012189:Retrospective Studies; D018426:SEER Program; D014481:United States / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Elderly; Endometrial cancer; HMG-CoA reductase inhibitor; Statin; Survival