title: Decreased serum vitamin D levels in Japanese patients with multiple sclerosis.
abstract: Data regarding vitamin D in multiple sclerosis (MS) in Asia are limited. We investigated whether Japanese MS patients show decreased serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], and vitamin D-binding protein (DBP) during winter. Mean serum 25(OH)D and 1,25(OH)2D levels were significantly lower in MS patients than in controls. There were no significant differences in serum 25(OH)D, 1,25(OH)2D, and DBP levels between patients or between controls from northern Japan (Hokkaido) and southern Japan (Kyushu). Serum vitamin D levels were low in Japanese MS patients but did not differ in patients from northern and southern Japan.
authors: Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan. Electronic address: niino@hok-mc.hosp.go.jp.
authors: Masaaki
authors: M
authors: Niino
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Shinya
authors: S
authors: Sato
authors: Sapporo Neurology Clinic, Sapporo, Japan.
authors: Toshiyuki
authors: T
authors: Fukazawa
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Katsuhisa
authors: K
authors: Masaki
authors: Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan; Department of Neurology, Hokkaido Medical Center, Sapporo, Japan.
authors: Yusei
authors: Y
authors: Miyazaki
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Dai
authors: D
authors: Matsuse
authors: Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Ryo
authors: R
authors: Yamasaki
authors: Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan.
authors: Eri
authors: E
authors: Takahashi
authors: Department of Neurology, Hokkaido Medical Center, Sapporo, Japan.
authors: Seiji
authors: S
authors: Kikuchi
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Jun-ichi
authors: J
authors: Kira
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D004185:Disability Evaluation; D004463:Ecology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000453:epidemiology; D011863:Radioimmunoassay; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014809:Vitamin D-Binding Protein / Q000097:blood; D055815:Young Adult
chemical_list: D014809:Vitamin D-Binding Protein; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D
keywords: Multiple sclerosis; Progression; Severity; Vitamin D; Vitamin D-binding protein