title: [Study on an inquiry-based teaching case in genomics curriculum: identifying virulence factors of Escherichia coli by using comparative genomics].
abstract: Genomics is the core subject of various "omics" and it also becomes a topic of increasing interest in undergraduate curricula of biological sciences. However, the study on teaching methodology of genomics courses was very limited so far. Here we report an application of inquiry-based teaching in genomics courses by using virulence factors of Escherichia coli as an example of comparative genomics study. Specially, students first built a multiple-genome alignment of different E. coli strains to investigate the gene conservation using the Mauve tool; then putative virulence factor genes were identified by using BLAST tool to obtain gene annotations. The teaching process was divided into five modules: situation, resources, task, process and evaluation. Learning-assessment results revealed that students had acquired the knowledge and skills of genomics, and their learning interest and ability of self-study were also motivated. Moreover, the special teaching case can be applied to other related courses, such as microbiology, bioinformatics, molecular biology and food safety detection technology.
authors: Department of Biotechnology, Zhejiang Yuying Vocational Technology College, Hangzhou 310018, China.
authors: Ji-Dong
authors: JD
authors: Zhou
authors: College of Food Science and Biotechnology, Zhejiang GongShang University, Hangzhou 310018, China.
authors: Yu-Dong
authors: YD
authors: Li
mesh_terms: D003479:Curriculum; D004926:Escherichia coli / Q000235:genetics* / Q000472:pathogenicity; D023281:Genomics / Q000193:education; D013663:Teaching; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D037521:Virulence Factors