title: Anti-troponin I antibodies in renal transplant patients.
abstract: OBJECTIVE
  To characterize the prevalence and clinical correlates of anti-troponin I antibodies in renal transplant patients.
  
  
  METHODS
  A group of 48 consecutive renal transplant patients under immunosuppressive therapy were studied. Anti-troponin I antibodies were measured and clinical data were retrieved.
  
  
  RESULTS
  An anti-troponin I antibody titer <1:40 was seen in most patients (30). IgG antibody titers ≥1:80 were seen in eight patients, with a single value of 1:160. Regarding IgM antibodies, in six cases titers ≥1:80 were seen, with one value of 1:320. In only one patient were both anti-troponin I antibody IgG and IgM titers 1:80 or higher. Clinical cardiac disease was seen in nine patients. The presence of an anti-troponin I antibody titer ≥1:80 was not associated with the presence of clinical cardiac disease (p=0.232), but was associated with statin therapy status (p=0.008), being less frequent in patients under statin therapy.
  
  
  CONCLUSIONS
  Anti-troponin I antibodies are seen in a minority of renal transplant patients, and are not associated with the presence of clinical heart disease, but are associated with lack of statin therapy.
authors: Faculdade de Medicina da Universidade do Porto, Portugal; Department of Cardiology, Hospital São João, Porto, Portugal. Electronic address: jplnunes@med.up.pt.
authors: José Pedro L
authors: JP
authors: Nunes
authors: Faculdade de Medicina da Universidade do Porto, Portugal; Department of Nephrology, Hospital São João, Porto, Portugal.
authors: Susana
authors: S
authors: Sampaio
authors: Department of Nephrology, Hospital São João, Porto, Portugal.
authors: Ana
authors: A
authors: Cerqueira
authors: University of Heidelberg, Heidelberg, Germany.
authors: Ziya
authors: Z
authors: Kaya
authors: Department of Cardiology, Hospital São João, Porto, Portugal.
authors: Nuno Pardal
authors: NP
authors: Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D019210:Troponin I / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D019210:Troponin I
keywords: Anti-troponin I antibodies; Anticorpos antitroponina I; Estatinas; Renal transplant; Statins; Transplante renal