title: Grading meningioma: a comparative study of thallium-SPECT and FDG-PET.
abstract: The purpose was to compare capability of fluorine-18 fluorodeoxyglucose (FDG)-PET and thallium-201 (Tl)-SPECT for grading meningioma.This retrospective study was conducted as a case-control study under approval by the institutional review board. In the hospital information system, 67 patients (22 men and 45 women) who had both FDG-PET and Tl-SPECT preoperative examinations were found with histopathologic diagnosis of meningioma. The maximum FDG uptake values of the tumors were measured, and they were standardized to the whole body (SUVmax) and normalized as gray matter ratio (SUVRmax). Mean and maximum Tl uptake ratios (TURmean and TURmax, respectively) of the tumors were measured and normalized as ratios to those of the contralateral normal brain. Receiver-operating characteristic curve analyses of the 4 indexes were conducted for differentiation between low- and high-grade meningiomas, and areas under the curves (AUCs) were compared. Correlation coefficients were calculated between these indexes and Ki-67.Fifty-six meningiomas were classified as grade I (low grade), and 11 were grade II or III (high grade). In all 4 indexes, a significant difference was observed between low- and high-grade meningiomas (P < 0.05). AUCs were 0.817 (SUVmax), 0.781 (SUVRmax), 0.810 (TURmean), and 0.831 (TURmax), and no significant difference was observed among the indexes. Their sensitivity and specificity were 72.7% to 90.9% and 71.4% to 87.5%, respectively. Correlation of the 4 indexes to Ki-67 was statistically significant, but coefficients were relatively low (0.273-0.355).Tl-SPECT, which can be used at hospitals without a cyclotron or an FDG distribution network, has high diagnostic capability of meningioma grades comparable to FDG-PET.
authors: From the Department of Diagnostic Imaging and Nuclear Medicine (SO, TO, AY, MK, YF, TO, MY, MK, KT); Department of Neurosurgery (YA, JCT, SM); and Department of Clinical Pathology (SM), Kyoto University Graduate School of Medicine, Kyoto, JAPAN.
authors: Sachi
authors: S
authors: Okuchi
authors: Tomohisa
authors: T
authors: Okada
authors: Akira
authors: A
authors: Yamamoto
authors: Mitsunori
authors: M
authors: Kanagaki
authors: Yasutaka
authors: Y
authors: Fushimi
authors: Tsutomu
authors: T
authors: Okada
authors: Moritaka
authors: M
authors: Yamauchi
authors: Masako
authors: M
authors: Kataoka
authors: Yoshiki
authors: Y
authors: Arakawa
authors: Jun C
authors: JC
authors: Takahashi
authors: Sachiko
authors: S
authors: Minamiguchi
authors: Susumu
authors: S
authors: Miyamoto
authors: Kaori
authors: K
authors: Togashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods*; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D019788:Fluorodeoxyglucose F18