title: A critical period for experience-dependent remodeling of adult-born neuron connectivity.
abstract: Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
authors: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and University Hospital of Cologne, 50931 Cologne, Germany; Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany. Electronic address: matteo.bergami@uk-koeln.de.
authors: Matteo
authors: M
authors: Bergami
authors: Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
authors: Giacomo
authors: G
authors: Masserdotti
authors: Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA, CONICET), C1405BWE Buenos Aires, Argentina.
authors: Silvio G
authors: SG
authors: Temprana
authors: Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
authors: Elisa
authors: E
authors: Motori
authors: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and University Hospital of Cologne, 50931 Cologne, Germany.
authors: Therese M
authors: TM
authors: Eriksson
authors: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and University Hospital of Cologne, 50931 Cologne, Germany.
authors: Jana
authors: J
authors: Göbel
authors: Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA, CONICET), C1405BWE Buenos Aires, Argentina.
authors: Sung Min
authors: SM
authors: Yang
authors: Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians-University Munich, 81377 Munich, Germany.
authors: Karl-Klaus
authors: KK
authors: Conzelmann
authors: Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA, CONICET), C1405BWE Buenos Aires, Argentina.
authors: Alejandro F
authors: AF
authors: Schinder
authors: Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany.
authors: Magdalena
authors: M
authors: Götz
authors: Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, 55128 Mainz, Germany; Focus Program Translational Neuroscience, Johannes Gutenberg University, 55131 Mainz, Germany.
authors: Benedikt
authors: B
authors: Berninger
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002478:Cells, Cultured; D003423:Critical Period, Psychological; D004622:Embryo, Mammalian; D004777:Environment; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D055495:Neurogenesis; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013997:Time Factors; D014162:Transfection
chemical_list: D008164:Luminescent Proteins