title: Amygdala response to anticipation of dyspnea is modulated by 5-HTTLPR genotype.
abstract: Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5-HTTLPR polymorphism impact this variability, we investigated healthy, 5-HTTLPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea ("perception") were differentially cued ("anticipation") and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype-based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: M Cornelia
authors: MC
authors: Stoeckel
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Roland W
authors: RW
authors: Esser
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Matthias
authors: M
authors: Gamer
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.|Neuroimaging Center Mainz (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany.
authors: Raffael
authors: R
authors: Kalisch
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors: Christian
authors: C
authors: Büchel
authors: Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.|Research Group Health Psychology, University of Leuven, Leuven, Belgium.
authors: Andreas
authors: A
authors: von Leupoldt
mesh_terms: D000328:Adult; D000483:Alleles; D000679:Amygdala / Q000502:physiology*; D059031:Anticipation, Psychological / Q000502:physiology*; D016022:Case-Control Studies; D004417:Dyspnea / Q000503:physiopathology* / Q000523:psychology; D005239:Fear / Q000502:physiology* / Q000523:psychology; D005260:Female; D059907:Functional Neuroimaging; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010465:Perception; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Anxiety; Genetics; Normal volunteers; Respiration; Sensation/Perception; fMRI/PET/MRI