title: β-catenin helices in the cytoplasm of sessile serrated adenoma/polyps and conventional colorectal adenomas.
abstract: Initiation and progression in conventional adenomas is triggered by deregulation of WNT/β-catenin signaling. In the absence of WNT signal (off-state), β-catenin prevents phosphorylation of GSK3β, leading to aberrant nuclear accumulation in human tumors. It has been postulated that mutations in the β-catenin gene are always associated with a morphologically-neoplastic course. While investigating the nuclear expression of β-catenin in 170 colorectal biopsies, we observed a non-previously reported phenomenon, namely the presence of β-catenin cytoplasmic helices in 29% (n=7) of 24 sessile serrated adenoma/polyps (SSA/P), in 24% (n=13) of 54 adenomas, in 8% (n=3) of 38 specimens with IBD, but in none (0/54) with normal mucosa. The earliest β-catenin helices were found at the bottom of SSA/P glands (the domain of stem cells in the colorectal mucosa). It is submitted that β-catenin helices might highlight a non-previously described cytoplasmic phenomenon evolving during the serrated-carcinoma pathway in SSA/P, and during the adenoma-carcinoma pathway in conventional adenomas.
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden Carlos.Rubio@ki.se.
authors: Carlos A
authors: CA
authors: Rubio
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Ann
authors: A
authors: Kaufeldt
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Rafat
authors: R
authors: Koha
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Mariko
authors: M
authors: Ushoida
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Jenny
authors: J
authors: Lindahl
authors: Department of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Lorand L
authors: LL
authors: Kis
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin
keywords: Serrated polyps; colon; conventional adenomas; rectum; β-catenin