title: Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.
abstract: Logopenic primary progressive aphasia (lvPPA) is a progressive language disorder characterized by anomia, difficulty repeating complex sentences, and phonological errors. The majority, although not all, lvPPA patients have underlying Alzheimer's disease. We aimed to determine whether clinical or neuroimaging features differ according to the deposition of Aβ on Pittsburgh-compound B PET in lvPPA. Clinical features, patterns of atrophy on MRI, hypometabolism on FDG-PET, and white matter tract degeneration were compared between six PiB-negative and 20 PiB-positive lvPPA patients. PiB-negative patients showed more asymmetric left-sided patterns of atrophy, hypometabolism and white matter tract degeneration, with greater left anteromedial temporal and medial prefrontal involvement, than PiB-positive patients. PiB-positive patients showed greater involvement of right temporoparietal and frontal lobes. There was very little evidence for clinical differences between the groups. Strikingly asymmetric neuroimaging findings with relatively preserved right hemisphere may provide clues that AD pathology is absent in lvPPA.
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States. Electronic address: whitwell.jennifer@mayo.edu.
authors: Jennifer L
authors: JL
authors: Whitwell
authors: Department of Neurology (Division of Speech Pathology), Mayo Clinic, Rochester, MN, United States.
authors: Joseph R
authors: JR
authors: Duffy
authors: Department of Neurology (Division of Speech Pathology), Mayo Clinic, Rochester, MN, United States.
authors: Edythe A
authors: EA
authors: Strand
authors: Department of Psychiatry and Psychology (Neuropsychology), Mayo Clinic, Rochester, MN, United States.
authors: Mary M
authors: MM
authors: Machulda
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States; Department of Information Technology, Mayo Clinic, Rochester, MN, United States.
authors: Matthew L
authors: ML
authors: Senjem
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States.
authors: Christopher G
authors: CG
authors: Schwarz
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States.
authors: Robert
authors: R
authors: Reid
authors: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
authors: Matthew C
authors: MC
authors: Baker
authors: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
authors: Ralph B
authors: RB
authors: Perkerson
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States.
authors: Val J
authors: VJ
authors: Lowe
authors: Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
authors: Rosa
authors: R
authors: Rademakers
authors: Department of Radiology, Mayo Clinic, Rochester, MN, United States.
authors: Clifford R
authors: CR
authors: Jack
authors: Department of Neurology (Division of Behavioral Neurology), Mayo Clinic, Rochester, MN, United states.
authors: Keith A
authors: KA
authors: Josephs
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis*; D018888:Aphasia, Primary Progressive / Q000175:diagnosis* / Q000473:pathology; D001284:Atrophy; D015415:Biomarkers / Q000032:analysis*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D019788:Fluorodeoxyglucose F18
keywords: Beta-amyloid; FDG-PET; Logopenic; Magnetic resonance imaging; Pittsburgh compound B; Primary progressive aphasia; Progranulin