title: Quality assessment of raw and processed Arctium lappa L. through multicomponent quantification, chromatographic fingerprint, and related chemometric analysis.
abstract: In traditional Chinese medicine, raw and processed herbs are used to treat different diseases. Suitable quality assessment methods are crucial for the discrimination between raw and processed herbs. The dried fruit of Arctium lappa L. and their processed products are widely used in traditional Chinese medicine, yet their therapeutic effects are different. In this study, a novel strategy using high-performance liquid chromatography and diode array detection coupled with multivariate statistical analysis to rapidly explore raw and processed Arctium lappa L. was proposed and validated. Four main components in a total of 30 batches of raw and processed Fructus Arctii samples were analyzed, and ten characteristic peaks were identified in the fingerprint common pattern. Furthermore, similarity evaluation, principal component analysis, and hierachical cluster analysis were applied to demonstrate the distinction. The results suggested that the relative amounts of the chemical components of raw and processed Fructus Arctii samples are different. This new method has been successfully applied to detect the raw and processed Fructus Arctii in marketed herbal medicinal products.
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.|Nanjing Haichang Chinese Medicine Group Corporation, Nanjing, P. R. China.|Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co. Ltd, Nanjing, P. R. China.
authors: Kunming
authors: K
authors: Qin
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors: Bin
authors: B
authors: Wang
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors: Weidong
authors: W
authors: Li
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors: Hao
authors: H
authors: Cai
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.|Nanjing Haichang Chinese Medicine Group Corporation, Nanjing, P. R. China.
authors: Danni
authors: D
authors: Chen
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors: Xiao
authors: X
authors: Liu
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors: Fangzhou
authors: F
authors: Yin
authors: Engineering Research Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, P. R. China.|Nanjing Haichang Chinese Medicine Group Corporation, Nanjing, P. R. China.|Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co. Ltd, Nanjing, P. R. China.
authors: Baochang
authors: B
authors: Cai
mesh_terms: D031170:Arctium / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D015999:Multivariate Analysis; D011786:Quality Control
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Bioactive compounds; Chromatographic fingerprint; Fructus Arctii; Quality assessment