title: Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane.
abstract: A number of novel 2-(N-(2-(5,5-dimethyl-1,3-dioxane-2-yl)ethyl)aminoacyl)amino-2-deoxy- d-glucopyranoside were synthesized from a readily available starting material, glucosamine, 2,2-dimethyl-1,3-propanediol and 1,1,3,3-tetramethoxypropane, and evaluated for their anti-inflammatory activity. Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice.
authors: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors: Li
authors: L
authors: Zeng
authors: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors: Guichao
authors: G
authors: Xu
authors: School of Pharmacy Institute of Peking University, Beijing 100191, PR China.
authors: Pengchao
authors: P
authors: Gao
authors: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors: Meng
authors: M
authors: Zhang
authors: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors: Hong
authors: H
authors: Li
authors: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: jwzhang2006@163.com.
authors: Jianwei
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004146:Dioxanes / Q000737:chemistry*; D015195:Drug Design; D004487:Edema / Q000188:drug therapy; D005944:Glucosamine / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D004146:Dioxanes; D057786:Peptidomimetics; D005944:Glucosamine
keywords: 1,3-Dioxane; Amino sugar; Glucosamine; Inflammation