title: XRMA and ToF-SIMS Analysis of Normal and Hypomineralized Enamel.
abstract: Molar incisor hypomineralization (MIH) is a developmental disturbance of the enamel. This study presents analyses of hypomineralized and normal enamel in first molar teeth diagnosed with MIH, utilizing time-of-flight secondary ion mass spectrometry area analyses and X-ray microanalysis of area and spot profiles in uncoated samples between gold lines which provide electrical conductivity. Statistical analysis of mean values allows discrimination of normal from MIH enamel, which has higher Mg and lower Na and P. Inductive analysis using complete data sets for profiles from the enamel surface to the enamel-dentin junction found that Mg, Cl and position in the profile provide useful discrimination criteria. Element profiles provide a visual complement to the inductive analysis and several elements also provide insight into the development of both normal and MIH enamel. The higher Mg content and different Cl profiles of hypomineralized enamel compared with normal enamel are probably related to a relatively short period during the development of ameloblasts between birth and the 1st year of life.
authors: 1Department of Pediatric Dentistry,Institute of Odontology at the Sahlgrenska Academy,University of Gothenburg,P.O. Box 450,SE 405 30 Gothenburg,Sweden.
authors: Lisa
authors: L
authors: Melin
authors: 2Department of Psychology,University of Gothenburg,P.O. Box 500,SE 405 30 Gothenburg,Sweden.
authors: Jesper
authors: J
authors: Lundgren
authors: 3Department of Chemical and Biological Engineering,Chalmers University of Technology,Kemivägen 10,412 96 Gothenburg,Sweden.
authors: Per
authors: P
authors: Malmberg
authors: 1Department of Pediatric Dentistry,Institute of Odontology at the Sahlgrenska Academy,University of Gothenburg,P.O. Box 450,SE 405 30 Gothenburg,Sweden.
authors: Jörgen G
authors: JG
authors: Norén
authors: 4Department of Occupational and Environmental Medicine,Sahlgrenska University Hospital,P.O. Box 414,SE 405 30 Gothenburg,Sweden.
authors: Fabian
authors: F
authors: Taube
authors: 5Department of Earth Sciences,University of Gothenburg,P.O. Box 460,SE 405 30 Gothenburg,Sweden.
authors: David H
authors: DH
authors: Cornell
mesh_terms: D002648:Child; D003743:Dental Enamel / Q000737:chemistry*; D003744:Dental Enamel Hypoplasia / Q000473:pathology*; D004577:Electron Probe Microanalysis; D006801:Humans; D008903:Minerals / Q000032:analysis*; D018629:Spectrometry, Mass, Secondary Ion; D013548:Sweden
chemical_list: D008903:Minerals
keywords: XRMA