title: MDR1 C3435T polymorphism and childhood acute lymphoblastic leukemia susceptibility: an updated meta-analysis.
abstract: BACKGROUND
  Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, though the etiology of the leukemia is poorly understood, both genetic and environmental factors appear to be involved. Previous studies investigating the association between MDR1 C3435T polymorphisms and risk of children with ALL reported controversial results.
  
  
  METHODS
  We performed a comprehensive meta-analysis to clarify the effect of MDR1 C3435T polymorphisms on risk of childhood ALL. The strength of the association was measured by odds ratio (OR) with 95% confidence interval (CI).
  
  
  RESULTS
  Nine studies were finally included, involving a total of 1462 cases and 1522 controls. There was no association between MDR1 C3435T polymorphism and children ALL risk in all of four models in overall populations (CT vs. CC: OR=0.86, 95% CI=0.65-1.15, P=0.310; TT vs. CC: OR=1.50, 95% CI=0.96-2.35, P=0.076; TT/CT vs. CC: OR=1.12, 95% CI=0.95-1.33, P=0.166; TT vs.
  OR=1.58, 95% CI=0.97-2.56, P=0.067). Subgroup analysis by race suggested that this association existed in Asians under the under the homozygote model and recessive model (TT vs. CC: OR=2.45, 95% CI=1.24-4.86, P=0.010; TT vs.
  OR=2.65, 95% CI=1.22-5.75, P=0.014).
  
  
  CONCLUSIONS
  This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
authors: Qingfang
authors: Q
authors: Yue
authors: Department of Hematology, Wuhan No. 1 Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
authors: Bei
authors: B
authors: Xiong
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
authors: Lei
authors: L
authors: Chen
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
authors: Ye
authors: Y
authors: Chen
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
authors: Fandan
authors: F
authors: Bu
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: lxy_wuhanxh@sina.com.
authors: Xinyue
authors: X
authors: Liu
authors: Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: chengfanjun001@sina.com.
authors: Fanjun
authors: F
authors: Cheng
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D002648:Child; D005006:Ethnicity / Q000235:genetics; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: Childhood acute lymphoblastic leukemia risk; MDR1; Meta-analysis; Polymorphism