title: Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels.
abstract: Saliva plays an important role in maintaining microbial homeostasis in the oral cavity, while salivary gland hypofunction predisposes the oral mucosa to pathologic alteration and increases the risk for oral candidiasis. This study sought to determine the salivary flow rate (SFR) and secretory immunoglobulin A (SIgA) levels in HIV-positive and HIV-negative individuals and evaluate their relationship with the determinants of oral candidiasis. Sixty HIV-positive (30 with and 30 without oral candidiasis) and 30 healthy HIV-negative individuals were enrolled. Cotton pellet was weighed pre- and post-saliva collection for the assessment of SFR, while SIgA levels were estimated by commercial ELISA (Diametra, Italy) kit. The mean ± SD, SFR and SIgA levels in HIV-positive individuals with candidiasis, without candidiasis and HIV-negative controls were 0.396 ± 0.290, 0.546 ± 0.355 and 0.534 ± 0.214 ml/min and 115.891 ± 37.621, 136.024 ± 51.075 and 149.418 ± 31.765 µg/ml, respectively. A positive correlation between low CD4 counts (indicator of immunodeficiency) and SIgA was observed in HIV-positive individuals with candidiasis (r = 0.373, p = 0.045). We also report here for the first time the significant decrease in SFR and SIgA levels in individuals presenting with pseudomembranous type of oral candidiasis and Candida albicans infection.
authors: DY Patil Dental College and Hospital, Pune, India.
authors: Bela
authors: B
authors: Mahajan
authors: Neeta
authors: N
authors: Bagul
authors: Rajiv
authors: R
authors: Desai
authors: Mamatha
authors: M
authors: Reddy
authors: Amit
authors: A
authors: Mahajan
authors: Ashwini
authors: A
authors: Shete
authors: Arun
authors: A
authors: Risbud
authors: Arati
authors: A
authors: Mane
mesh_terms: D000328:Adult; D002176:Candida albicans / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D007558:Italy; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D012463:Saliva / Q000276:immunology*; D055815:Young Adult
chemical_list: D007071:Immunoglobulin A, Secretory