title: Comparison of the quality of different magnetic resonance image sequences of multiple myeloma.
abstract: OBJECTIVE
  To compare the image quality of T1WI fat phase,T1WI water phase, short time inversion recovery (STIR) sequence, and diffusion weighted imaging (DWI) sequence in the evaluation of multiple myeloma (MM).
  
  
  METHODS
  Totally 20MM patients were enrolled in this study. All patients underwent scanning at coronal T1WI fat phase, coronal T1WI water phase, coronal STIR sequence, and axial DWI sequence. The image quality of the four different sequences was evaluated. The image was divided into seven sections(head and neck, chest, abdomen, pelvis, thigh, leg, and foot), and the signal-to-noise ratio (SNR) of each section was measured at 7 segments (skull, spine, pelvis, humerus, femur, tibia and fibula and ribs) were measured. In addition, 20 active MM lesions were selected, and the contrast-to-noise ratio (CNR) of each scan sequence was calculated.
  
  
  RESULTS
  The average image quality scores of T1WI fat phase,T1WI water phase, STIR sequence, and DWI sequence were 4.19 ± 0.70,4.16 ± 0.73,3.89 ± 0.70, and 3.76 ± 0.68, respectively. The image quality at T1-fat phase and T1-water phase were significantly higher than those at STIR (P=0.000 and P=0.001) and DWI sequence (both P=0.000); however, there was no significant difference between T1-fat and T1-water phase (P=0.723)and between STIR and DWI sequence (P=0.167). The SNR of T1WI fat phase was significantly higher than those of the other three sequences (all P=0.000), and there was no significant difference among the other three sequences (all P>0.05). Although the CNR of DWI sequences was slightly higher than those of the other three sequences,there was no significant difference among all of them (all P>0.05).
  
  
  CONCLUSIONS
  Imaging at T1WI fat phase,T1WI water phase, STIR sequence, and DWI sequence has certain advantages,and they should be combined in the diagnosis of MM.
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Zhao-yong
authors: ZY
authors: Sun
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Hai-bo
authors: HB
authors: Zhang
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Shuo
authors: S
authors: Li
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Yun
authors: Y
authors: Wang
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Hua-dan
authors: HD
authors: Xue
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Zheng-yu
authors: ZY
authors: Jin
mesh_terms: D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005269:Femur; D006257:Head; D006801:Humans; D009101:Multiple Myeloma; D009333:Neck; D010388:Pelvis; D059629:Signal-To-Noise Ratio; D013131:Spine; D013848:Thigh; D013909:Thorax; D014867:Water
chemical_list: D003287:Contrast Media; D014867:Water