title: In vitro and in vivo evaluation of a polylactic acid-bioactive glass composite for bone fixation devices.
abstract: Poly(lactic acid) is nowadays among the most used bioabsorbable materials for medical devices. To promote bone growth on the material surface and increase the degradation rate of the polymer, research is currently focused on organic-inorganic composites by adding a bioactive mineral to the polymer matrix. The purpose of this study was to investigate the ability of a poly(L,DL-lactide)-Bioglass® (P(L,DL)LA-Bioglass(®) 45S5) composite to be used as a bone fixation device. In vitro cell viability testing of P(l,dl)LA based composites containing different amounts of Bioglass(®) 45S5 particles was investigated. According to the degradation rate of the P(L,DL)LA matrix and the cytocompatibility experiments, the composite with 30 wt % of Bioglass® particles seemed to be the best candidate for further investigation. To study its behavior after immersion in simulated physiological conditions, the degradation of the composite was analyzed by measuring its weight loss and mechanical properties and by proceeding with X-ray tomography. We demonstrated that the presence of the bioactive glass significantly accelerated the in vitro degradation of the polymer. A preliminary in vivo investigation on rabbits shows that the addition of 30 wt % of Bioglass(®) in the P(L,DL)LA matrix seems to trigger bone osseointegration especially during the first month of implantation. This composite has thus strong potential interest for health applications.
authors: Université de Lyon, CNRS, Villeurbanne, France.|Université Claude Bernard Lyon1, MATEIS UMR5510, F-69373, Lyon 8, France.
authors: Gwenaelle
authors: G
authors: Vergnol
authors: Université de Lyon, CNRS, Villeurbanne, France.|INSA-Lyon, MATEIS UMR5510, F-69621, Villeurbanne, France.
authors: Nathalie
authors: N
authors: Ginsac
authors: Université de Lyon, CNRS, Villeurbanne, France.|Université Claude Bernard Lyon1, MATEIS UMR5510, F-69373, Lyon 8, France.
authors: Pascaline
authors: P
authors: Rivory
authors: Université de Lyon, CNRS, Villeurbanne, France.|INSA-Lyon, MATEIS UMR5510, F-69621, Villeurbanne, France.
authors: Sylvain
authors: S
authors: Meille
authors: Université de Lyon, CNRS, Villeurbanne, France.|INSA-Lyon, MATEIS UMR5510, F-69621, Villeurbanne, France.
authors: Jean-Marc
authors: JM
authors: Chenal
authors: Université de Lyon, CNRS, Villeurbanne, France.|Université Claude Bernard Lyon1, MATEIS UMR5510, F-69373, Lyon 8, France.
authors: Sandra
authors: S
authors: Balvay
authors: Université de Lyon, CNRS, Villeurbanne, France.|INSA-Lyon, MATEIS UMR5510, F-69621, Villeurbanne, France.|Institut Universitaire de France, 103 bd Saint Michel, F-75005, Paris, France.
authors: Jérôme
authors: J
authors: Chevalier
authors: Université de Lyon, CNRS, Villeurbanne, France.|Université Claude Bernard Lyon1, MATEIS UMR5510, F-69373, Lyon 8, France.
authors: Daniel J
authors: DJ
authors: Hartmann
mesh_terms: D000818:Animals; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D016268:Internal Fixators; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D016348:Osseointegration / Q000187:drug effects*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
chemical_list: C022107:Bioglass; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)
keywords: bioactive glass; biocompatibility; biomaterial; degradation; polylactic acid