title: [TSC-22D proteins: new regulators of cell homeostasis?].
abstract: The GILZ (glucocorticoid-induced leucine zipper) protein has first been identified as a glucocorticoid-responsive gene and is now presented as a major regulator of inflammation. Expanding literature documents a role for GILZ as a mediator of the immuno-modulatory and anti-inflammatory effects of glucocorticoids, mainly through interference with key signal transduction pathways such as nuclear factor-kappa B (NF-kB) or activated protein-1 (AP-1). The TSC-22 (TGF-β-stimulated clone-22) protein is described as an apoptosis modulator and as a new tumor suppressor gene. GILZ and TSC-22, characterized by the presence of a leucine zipper domain and a TSC-box, belong to the TSC-22D (TSC-22 domain) family of proteins which comprises today 18 members. Functions of these proteins suggest that this family plays a major role in cell homeostasis and in the regulation of the immune system.
authors: Université Paris-Sud, Inserm UMR 996, faculté de pharmacie, 5, rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors: Aurélie
authors: A
authors: Pépin
authors: Université Paris-Sud, Inserm UMR 996, faculté de pharmacie, 5, rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors: Armelle
authors: A
authors: Biola-Vidamment
authors: Université Paris-Sud, Inserm UMR 996, faculté de pharmacie, 5, rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors: Perle
authors: P
authors: Latré de Laté
authors: Université Paris-Sud, Inserm UMR 996, faculté de pharmacie, 5, rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors: Marie-Alix
authors: MA
authors: Espinasse
authors: Inserm UMR 955, faculté de médecine, 51, avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
authors: Véronique
authors: V
authors: Godot
authors: Université Paris-Sud, Inserm UMR 996, faculté de pharmacie, 5, rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors: Marc
authors: M
authors: Pallardy
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics; D005810:Multigene Family / Q000502:physiology; D011487:Protein Conformation; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D012097:Repressor Proteins; C099726:TSC22D1 protein, human