title: Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population.
abstract: Recent genome-wide association study (GWAS) on esophageal squamous-cell carcinoma (ESCC) among Chinese population has identified two novel single nucleotide polymorphisms (SNPs) rs11066280 and rs2074356 on C12orf51 gene. We hypothesized that SNPs rs11066280 and rs2074356 could influence gastric cancer survival outcomes. We genotyped the SNPs rs11066280 and rs2074356 in 940 patients with surgically resected gastric cancer. Analyses of genotype association with survival outcomes were assessed by the Kaplan-Meier method, Cox proportional hazards models and the log-rank test. There was no significant association between rs11066280 and survival of gastric cancer. However, in the stratification analysis of histology, we found that the rs11066280 TA/AA genotypes were associated with a poor survival of intestinal-type gastric cancer (log-rank P=0.041, hazard ratio [HR]=1.40, 95% confidence interval [CI]=1.02-1.93), Moreover, this hazardous effect was more prominent among patients with tumor size>5cm, no distant metastasis, chemotherapy and drinking. No significant association was observed between rs2074356 and the survival of gastric cancer. C12orf5 rs11066280 could be useful marker of survival assessment and individualized clinical therapy for gastric cancer, particularly among the intestinal-type gastric cancer.
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors: Gang
authors: G
authors: Zhang
authors: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors: Dongying
authors: D
authors: Gu
authors: Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Qinghong
authors: Q
authors: Zhao
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Haiyan
authors: H
authors: Chu
authors: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors: Zhi
authors: Z
authors: Xu
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Meilin
authors: M
authors: Wang
authors: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors: Cuiju
authors: C
authors: Tang
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Dongmei
authors: D
authors: Wu
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Na
authors: N
authors: Tong
authors: Department of General Surgery, Yixing Cancer Hospital, Yixing, China.
authors: Weida
authors: W
authors: Gong
authors: Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China.
authors: Jianwei
authors: J
authors: Zhou
authors: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors: Yong
authors: Y
authors: Xu
authors: Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: drzdzhang@gmail.com.
authors: Zhengdong
authors: Z
authors: Zhang
authors: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: jinfeichen@sohu.com.
authors: Jinfei
authors: J
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007422:Intestines / Q000473:pathology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016016:Proportional Hazards Models; D011506:Proteins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D011506:Proteins
keywords: C12orf51; Gastric cancer; Polymorphism; Survival