title: The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio.
abstract: Inflammation plays an important role in the pathophysiology of vascular disease. In this review, we consider the associations between the neutrophil-lymphocyte ratio (NLR; an indicator of inflammation) and vascular disease and its associated risk factors. The NLR has received attention due to its role as an independent prognostic factor for coronary artery disease. The NLR can also be affected by atherosclerotic risk factors, such as hypercholesterolemia, metabolic syndrome, diabetes, and hypertension. Importantly, it can predict mortality in cardiovascular diseases. There are also reports of a positive correlation between the NLR and commonly used inflammatory markers. Inflammation is important not only in pathophysiology but also clinical outcomes of many diseases. The NLR is a widely available, easily derived, and reproducible marker of inflammation. Unlike many other inflammatory markers, the NLR is inexpensive and readily available and it provides additional risk stratification beyond conventional risk scores.
authors: Department of Cardiology, Eskisehir Military Hospital, Eskişehir, Turkey drsevketb@gmail.com.
authors: Sevket
authors: S
authors: Balta
authors: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors: Turgay
authors: T
authors: Celik
authors: Department of Clinical Biochemistry, University College London Medical School London, University College London (UCL), London, England.
authors: Dimitri P
authors: DP
authors: Mikhailidis
authors: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors: Cengiz
authors: C
authors: Ozturk
authors: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors: Sait
authors: S
authors: Demirkol
authors: Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Aparci
authors: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors: Atila
authors: A
authors: Iyisoy
mesh_terms: D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D009504:Neutrophils / Q000166:cytology*; D012307:Risk Factors; D014652:Vascular Diseases / Q000097:blood
chemical_list: D015415:Biomarkers
keywords: atherosclerosis; inflammation; neutrophil–lymphocyte ratio