title: Turning peptides in comb silicone polymers.
abstract: We have recently reported on a new class of silicone-peptide' biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 15 avenue Charles Flahault, 34000, Montpellier, France; Institut Charles Gerhardt, UMR5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
authors: Said
authors: S
authors: Jebors
authors: Coline
authors: C
authors: Pinese
authors: Benjamin
authors: B
authors: Nottelet
authors: Karine
authors: K
authors: Parra
authors: Muriel
authors: M
authors: Amblard
authors: Ahmad
authors: A
authors: Mehdi
authors: Jean
authors: J
authors: Martinez
authors: Gilles
authors: G
authors: Subra
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D051379:Mice; D050296:Microbial Viability / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D012828:Silicones / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D010455:Peptides; D011108:Polymers; D012828:Silicones; D012833:Siloxanes; D014867:Water
keywords: comb-polymers; hydroxysilyl peptides; peptide materials; polysiloxane; silicone