title: Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers' Cohort (MTC, ESMaestras).
abstract: OBJECTIVE
  Obesity is a major risk factor for several cancers, including female cancers. Endogenous hormones and inflammatory factors may mediate the association between anthropometric measures and cancer risk, although these associations have been studied mainly in Caucasians. The aim of the current study was to explore the association of circulating hormones, adipokines, and inflammatory factors with obesity and overweight in premenopausal Mexican women.
  
  
  METHODS
  We conducted a cross-sectional analysis of 504 premenopausal women from the large Mexican Teachers' Cohort (MTC, ESMaestras) study to determine the association of insulin-like growth factor I (IGF-I), its major circulating binding protein (IGFBP-3), leptin, adiponectin, C-peptide, and C-reactive protein with comprehensive measures of body size. Biomarkers were measured by immunoassays. Multivariate regression analyses were performed to compare geometric mean biomarker concentrations with measured markers of body size and adiposity.
  
  
  RESULTS
  Mean IGF-I and IGFBP-3 concentrations significantly increased with increasing height and leg length. Concentrations of IGF-I, adiponectin, and the IGF-I/IGFBP-3 ratio strongly decreased with increasing BMI, weight, waist and hip circumferences, waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), while CRP, leptin, C-peptide concentrations, and the leptin/adiponectin ratio strongly increased. Adiponectin and the leptin/adiponectin ratio remained significantly related to measures of central adiposity (waist circumference, WHpR, and WHtR) after adjustment by body mass index.
  
  
  CONCLUSIONS
  The results of our study suggest a strong relation between biomarkers and body size in this study population and suggest that different fat depots may have different metabolic properties.
authors: International Agency for Research on Cancer (IARC), Lyon, France.
authors: Sabina
authors: S
authors: Rinaldi
authors: Carine
authors: C
authors: Biessy
authors: Maria
authors: M
authors: de la Luz Hernandez
authors: Martin
authors: M
authors: Lajous
authors: Eduardo
authors: E
authors: Ortiz-Panozo
authors: Elsa
authors: E
authors: Yunes
authors: Ruy
authors: R
authors: Lopez-Ridaura
authors: Gabriela
authors: G
authors: Torres-Mejia
authors: Isabelle
authors: I
authors: Romieu
mesh_terms: D050154:Adiposity; D000328:Adult; D015415:Biomarkers; D015992:Body Mass Index; D049628:Body Size; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D002097:C-Reactive Protein / Q000096:biosynthesis; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007118:Immunoassay; D007249:Inflammation / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D020738:Leptin / Q000097:blood; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood; D017697:Premenopause; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D002096:C-Peptide; C583557:IGF1 protein, human; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein