title: Preoperative neutrophil-lymphocyte count ratio helps predict the grade of glial tumor - a pilot study.
abstract: Neutrophil-lymphocyte count ratio (NLCR) is a recognized prognostic marker for renal, lung or colorectal carcinomas. The aim of the present study was to determine whether the preoperative value of NLCR might serve as a predictive marker for glial tumors' grading.
  
  
  METHODS
  The retrospective analysis of NLCR was performed in neurosurgical patients treated for glial brain tumors. The preoperative NLCR was analyzed in accordance with WHO glial tumors' classification, which distinguishes G1, G2, G3 and G4 (glioblastoma) tumors.
  
  
  RESULTS
  The analysis of NLCR was performed in 424 patients (258 males and 166 females) aged 53 ± 16 years who underwent either an open surgery or stereotactic biopsy for a glial brain tumor. G1 was diagnosed in 22 patients, G2 - in 71 patients, G3 - in 63 patients and G4 - in 268 patients. The highest value of NLCR was noted in G4 patients (5.08 [3.1; 8.7] - median [quartiles 1 and 3, respectively]) and was significantly higher compared to G3 (p<0.01), G2 (p<0.001) and G1 (p<0.01) groups. Moreover, NLCR was significantly higher in group G3 than G2 (p<0.05). ROC curve analysis showed 2.579 as a cut-off point for prediction of glioblastoma.
  
  
  CONCLUSIONS
  Preoperative NLCR measurement corresponds with a glial brain tumor grading.
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
authors: Przemyslaw
authors: P
authors: Zadora
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland. Electronic address: w.dabrowski5@yahoo.com.
authors: Wojciech
authors: W
authors: Dabrowski
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
authors: Katarzyna
authors: K
authors: Czarko
authors: Department of Epidemiology, Medical University of Lublin, Lublin, Poland.
authors: Agata
authors: A
authors: Smolen
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
authors: Edyta
authors: E
authors: Kotlinska-Hasiec
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
authors: Krzysztof
authors: K
authors: Wiorkowski
authors: Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
authors: Agnieszka
authors: A
authors: Sikora
authors: Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.
authors: Bozena
authors: B
authors: Jarosz
authors: Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.
authors: Krzysztof
authors: K
authors: Kura
authors: Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland; Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland.
authors: Radosław
authors: R
authors: Rola
authors: Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.
authors: Tomasz
authors: T
authors: Trojanowski
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005910:Glioma / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009504:Neutrophils / Q000166:cytology; D010865:Pilot Projects; D057234:Preoperative Period
chemical_list: D014408:Biomarkers, Tumor
keywords: Glial brain tumor; Glioblastoma; Neutrophil/lymphocyte count ratio