title: Potential biomarkers for early diagnosis of acute aortic dissection.
abstract: OBJECTIVE
  The purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD).
  
  
  METHODS
  76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD.
  
  
  RESULTS
  The serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%).
  
  
  CONCLUSIONS
  smMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.
authors: Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
authors: Wen
authors: W
authors: Peng
authors: Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
authors: Zhenyu
authors: Z
authors: Peng
authors: Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China. Electronic address: laochaicn@aliyun.com.
authors: Xiangping
authors: X
authors: Chai
authors: Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
authors: Qingyi
authors: Q
authors: Zhu
authors: Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
authors: Guifang
authors: G
authors: Yang
authors: Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
authors: Qin
authors: Q
authors: Zhao
authors: Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China.
authors: Shenghua
authors: S
authors: Zhou
mesh_terms: D000784:Aortic Dissection / Q000097:blood / Q000175:diagnosis*; D001014:Aortic Aneurysm / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology*; D042241:Early Diagnosis; D004636:Emergency Service, Hospital; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: Acute aortic dissection; Biomarkers; D-dimer; Polycystin 1; Smooth muscle myosin heavy chain; Soluble elastin fragments; α-Smooth muscle actin