title: Peripheral neuropathy associated with ipilimumab: a report of 2 cases.
abstract: Ipilimumab, a monoclonal antibody targeting human cytotoxic T-lymphocyte-associated antigen 4, was approved by the FDA and European Medicines Agency for the treatment of metastatic melanoma. Immune-related adverse effects can occur with the use of this agent, but peripheral nervous system problems are rare. We report 2 cases of ipilimumab-induced polyneuropathy.
authors: Departments of *Neurology †Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors: Iyavut
authors: I
authors: Thaipisuttikul
authors: Paul
authors: P
authors: Chapman
authors: Edward K
authors: EK
authors: Avila
mesh_terms: D000588:Amines / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D060908:CTLA-4 Antigen / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000188:drug therapy; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage; D000077206:Gabapentin; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D000074324:Ipilimumab; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D009431:Neural Conduction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage
chemical_list: D000588:Amines; D000911:Antibodies, Monoclonal; D060908:CTLA-4 Antigen; D003509:Cyclohexanecarboxylic Acids; D007166:Immunosuppressive Agents; D000074324:Ipilimumab; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D008775:Methylprednisolone