title: Treatment of transmissible venereal tumors in dogs with intratumoral interleukin-2 (IL-2). A pilot study.
abstract: OBJECTIVE
  To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2).
  
  
  METHODS
  We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2.
  
  
  RESULTS
  Three months after injection of IL-2, the tumors in 2/13 dogs had regressed completely, those in 1/13 had regressed partially, and 4/13 dogs had stable disease.
  
  
  CONCLUSIONS
  Local IL-2 treatment of TVT is therapeutically effective, as indicated by complete regression (CR), partial regression (PR) and stable disease (SD) of the tumors of 7 out of 13 dogs. In addition, we observed that the intratumoral treatment with IL-2 did not cause any toxic side-effects.
authors: Department of Urology, VU Medical Centre, Amsterdam, the Netherlands w.denotter@VUmc.nl w.den.otter@live.nl.
authors: Willem
authors: W
authors: Den Otter
authors: Veterinary Centre Curacao, Ronde Klip, Curçao, the Netherlands.
authors: Margot
authors: M
authors: Hack
authors: Department of Urology, VU Medical Centre, Amsterdam, the Netherlands.
authors: John J L
authors: JJ
authors: Jacobs
authors: Veterinary Centre Korte Akkeren, Gouda, the Netherlands.
authors: Jurgen F V
authors: JF
authors: Tan
authors: Department of Pathology, VU Medical Centre, Amsterdam, the Netherlands.
authors: Lawrence
authors: L
authors: Rozendaal
authors: Department of Urology, VU Medical Centre, Amsterdam, the Netherlands.
authors: R Jeroen A
authors: RJ
authors: Van Moorselaar
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D014685:Venereal Tumors, Veterinary / Q000628:therapy*
chemical_list: D007376:Interleukin-2
keywords: IL-2; Interleukin-2; TVT; Transmissible venereal tumors; dogs