title: Should close contacts of returning travellers with typhoid fever be protected by vaccination?
abstract: Increasing international travel to areas endemic for typhoid fever correlates with increased risk for travellers to contract the disease. At home, the acutely ill/convalescent patients may pose some risk to their close contacts. In Finland an unofficial guideline suggests vaccination for close contacts of patients with acute typhoid fever; in other developed countries, routine typhoid vaccinations are only recommended to contacts of chronic carriers. This paper discusses the possibilities and limitations of prophylactic/post-exposure typhoid vaccination for contacts of patients with acute disease.
authors: Inflammation Center, Clinic of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Finland; Department of Clinical Medicine, University of Helsinki, Helsinki, Finland. Electronic address: anu.kantele@hus.fi.
authors: A
authors: A
authors: Kantele
mesh_terms: D005387:Finland; D006801:Humans; D056990:Post-Exposure Prophylaxis; D065129:Pre-Exposure Prophylaxis; D012485:Salmonella typhi / Q000276:immunology*; D014195:Travel; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage*; D014611:Vaccination
chemical_list: D014436:Typhoid-Paratyphoid Vaccines
keywords: Post-exposure; Salmonella Paratyphi; Salmonella Typhi; Salmonella Typhi Ty21a; Typhoid fever; Vaccination; Vi capsular polysaccharide