title: Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel-Based Morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI.
abstract: OBJECTIVE
  The aim of this study is to compare gray matter (GM) volume and white matter (WM) integrity in Apolipoprotein E4 (ApoE ε4) carriers with that of ApoE ε4 noncarriers using the voxel-based morphometry and diffusion tensor imaging (DTI) to investigate the effect of the ApoE ε4 on brain structures in subjective memory impairment (SMI) without white matter hyperintensities (WMH).
  
  
  METHODS
  Altogether, 26 participants with SMI without WMH were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All participants were ApoE genotyped (ApoE ε4 carriers: n = 13, matched ApoE ε4 noncarriers: n = 13) and underwent 3-tesla magnetic resonance imaging (MRI) including 3-dimensional volumetric images for GM volume and DTI for WM integrity.
  
  
  RESULTS
  ApoE ε4 carriers compared with noncarriers in SMI without WMH showed the atrophy of GM in inferior temporal gyrus, inferior parietal lobule, anterior cingulum, middle frontal gyrus, and precentral gyrus and significantly lower fractional anisotropy WM values in the splenium of corpus callosum and anterior corona radiate.
  
  
  CONCLUSIONS
  Our findings suggest that the ApoE ε4 is associated with both atrophy of GM volume and disruption of WM integrity in SMI without WMH.
authors: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors: Young-Min
authors: YM
authors: Lee
authors: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.
authors: Ji-Kyung
authors: JK
authors: Ha
authors: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors: Je-Min
authors: JM
authors: Park
authors: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors: Byung-Dae
authors: BD
authors: Lee
authors: Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.|Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
authors: EunSoo
authors: E
authors: Moon
authors: Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
authors: Young-In
authors: YI
authors: Chung
authors: Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
authors: Ji-Hoon
authors: JH
authors: Kim
authors: Department of Radiology, Pusan National University School of Medicine, Busan, Korea.
authors: Hak-Jin
authors: HJ
authors: Kim
authors: Department of Biomedical Engineering and FIRST, Inje University, Gimhae, Korea.
authors: Chi-Woong
authors: CW
authors: Mun
authors: Department of Biomedical Engineering and FIRST, Inje University, Gimhae, Korea.
authors: Tae-Hyung
authors: TH
authors: Kim
authors: Department of Psychiatry, Medical School, Inje University, Haeundae Paik Hospital, Busan, Korea.
authors: Young-Hoon
authors: YH
authors: Kim
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D005838:Genotype; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009929:Organ Size / Q000235:genetics; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D053327:Apolipoprotein E4
keywords: Apolipoprotein E4; gray matter volume; subjective memory impairment; white matter integrity