title: Association of serum chemerin levels with the severity of coronary artery disease in patients with metabolic syndrome.
abstract: OBJECTIVE
  The newly identified adipokine chemerin has been shown to be associated with the components of MetS, inflammation and insulin resistance. In this study, the relationship between serum chemerin levels and the presence and severity of coronary artery disease (CAD) was evaluated in patients with MetS.
  
  
  METHODS
  The study population consisted of 84 MetS patients (43 patients with CAD and 41 without CAD), who had coronary angiography for suspected coronary artery disease, and 46 healthy individuals as a control group. Angiographic CAD was defined as ≥ 50% luminal diameter stenosis of at least one major epicardial coronary artery. The severity of CAD was determined by the Gensini score. Serum chemerin levels were measured with enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum chemerin levels were significantly higher in patients with MetS (n=84) than those in the control group (120.47±25.32 vs. 90.4±11.4 ng/ml P < 0.001). In addition, MetS patients with CAD had higher chemerin levels than MetS patients without CAD (128.7±26.6 vs. 115.7±15.2 ng/ml, P < 0.001). Serum chemerin levels had a significant positive correlation with the Gensini score (r=0.58, P < 0.001). Multivariate logistic regression demonstrated that serum high-density lipoprotein cholesterol (HDL-C) and chemerin levels were significant and independent predictors for determining the presence of angiographic CAD (OR=1.009, 95% CI: 0.972-1.057; P=0.003 and OR=0.925, 95% CI: 0.896-0.922; P < 0.001, respectively).
  
  
  CONCLUSIONS
  This study demonstrated that in patients with MetS, chemerin levels were higher in patients with CAD than patients without CAD and also showed a significant positive correlation with CAD severity.
authors: Department of Cardiology, Gazi State Hospital Samsun, Turkey.
authors: Gökhan
authors: G
authors: Aksan
authors: Departmant of Cardiology, Aksaray State Hospital Aksaray, Turkey.
authors: Sinan
authors: S
authors: İnci
authors: Departmant of Cardiology, Aksaray State Hospital Aksaray, Turkey.
authors: Gökay
authors: G
authors: Nar
authors: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University Samsun, Turkey.
authors: Korhan
authors: K
authors: Soylu
authors: Departmant of Cardiology, Artvin State Hospital Artvin, Turkey.
authors: Ömer
authors: Ö
authors: Gedikli
authors: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University Samsun, Turkey.
authors: Serkan
authors: S
authors: Yüksel
authors: Department of Microbiology, Gazi State Hospital Samsun, Turkey.
authors: Metin
authors: M
authors: Özdemir
authors: Departmant of Biochemistry, Aksaray State Hospital Aksaray, Turkey.
authors: Rukiye
authors: R
authors: Nar
authors: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University Samsun, Turkey.
authors: Murat
authors: M
authors: Meriç
authors: Department of Cardiology, Faculty of Medicine, Ondokuz Mayis University Samsun, Turkey.
authors: Mahmut
authors: M
authors: Şahin
keywords: Chemerin; coronary artery disease; gensini score; metabolic syndrome