title: Intracranial multiple germ cell tumors: a case report and review of literature.
abstract: Intracranial multiple germ cell tumors (GCTs) are rare. In this article, we reported a case of intracranial multiple GCTs in an 18-year-old boy with symptoms of psychosis for 8 months also. Tumors in the pineal, sellar region, corpus callosum, bilateral lateral ventricles and fourth ventricle were confirmed by enhanced magnetic resonance imaging (MRI) and stereotactic biopsy. Immunohistochemical analysis results demonstrated that the tumor cells were positive for CD117 and placental alkaline phosphatase (PLAP). The patient was treated by radiotherapy and the prescribed radiation doses were 18 Gy. After near 24 months of follow-up, no local recurrence and distant metastasis has been found.
authors: Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China.
authors: Ping
authors: P
authors: Yang
authors: Institute of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha, China ; Department of Anatomy, Hunan University of Chinese Medicine Changsha, China.
authors: Liang
authors: L
authors: Li
authors: Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China.
authors: Weiping
authors: W
authors: Kuang
authors: Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China.
authors: Bo
authors: B
authors: Li
authors: Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China.
authors: Bin
authors: B
authors: Zhou
authors: Department of Chronic Disease, Center for Disease Control and Prevention of Yuhua District Changsha, China.
authors: Jingjing
authors: J
authors: Yang
authors: Institute of Diagnostics of Traditional Chinese Medicine, Hunan University of Chinese Medicine Changsha, China.
authors: Huiyong
authors: H
authors: Huang
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001932:Brain Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D016371:Cranial Irradiation; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D011618:Psychotic Disorders / Q000209:etiology; D011879:Radiotherapy Dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Intracranial multiple germ cell tumors; corpus callosum; lateral ventricles; pineal; sellar region; symptoms of psychosis