title: The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.
abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer's disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury. The most well known genetic risk factor for LOAD is inheritance of the apolipoprotein (apo) E4 allele. Recently, rare variants of TREM2 have been reported as a significant risk factor for LOAD, comparable to inheritance of apoE4. In this review we will focus on the role(s) of TREM2 in AD as well as in other neurodegenerative disorders.
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Faris
authors: F
authors: Yaghmoor
authors: Pathology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Ahmed
authors: A
authors: Noorsaeed
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Samar
authors: S
authors: Alsaggaf
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Waleed
authors: W
authors: Aljohani
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Henrieta
authors: H
authors: Scholtzova
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA ; Psychiatry, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA ; Physiology and Neuroscience, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY10016, USA ; King Abdulaziz University, School of Medicine, Jeddah, Saudi Arabia.
authors: Allal
authors: A
authors: Boutajangout
authors: Departments of Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA ; Pathology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA ; Psychiatry, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
authors: Thomas
authors: T
authors: Wisniewski
keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Fronto-temporal dementia; Hereditary diffused leukoencephalopathy with spheroids; Nasu-hakola disease; Parkinson’s disease; TREM-2