title: [Insulin therapy in type 2 diabetes: a review of "when" over "how" up to "why"].
abstract: Type 2 Diabetes is characterized by its progressive character. An intensification of the therapy is necessary in most cases over the years and insulin is typically used as an add-on agent when oral antidiabetic regimes are judged to be no longer sufficient. However, insulin can also be used in the initial phase of the disease directly after diagnosis of diabetes. Intermittent worsening of glycemic control (e.g. due to infectious diseases or corticosteroids) may be additional indications for an insulin treatment at an earlier stage. Noticeably, insulin can often be stopped if the triggering event or treatment is reversible, thereby countering the widely spread fear of dependency on insulin. We recommend a rather cautious starting dose of insulin and individual adaptations thereafter. Well-informed patients can also perform such adaptations themselves.
authors: Universitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universität Bern.
authors: Markus
authors: M
authors: Laimer
authors: Universitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universität Bern.
authors: Stefan
authors: S
authors: Jenni
authors: Universitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universität Bern.
authors: Christoph
authors: C
authors: Stettler
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Insulin; Therapie des Typ-2-Diabetes mellitus; Typ-2-Diabetes mellitus; diabète de type 2; insulin treatment; insulinothérapie; type 2 diabetes mellitus