title: Impact of previous acute pulmonary oedema after transcatheter aortic valve implantation: insight from French Aortic National CoreValve and Edwards 2 [FRANCE 2]registry.
abstract: BACKGROUND
  The prognostic value of previous pulmonary oedema (PO) has not been thoroughly investigated in a large-cohort of TAVI-patients. The aim of this study was to assess the influence of previous clinical history of acute PO in severe aortic stenosis (AS) patients undergoing transcatheter aortic valve implantation (TAVI).
  
  
  METHODS
  Data were analyzed for 3195 patients enrolled in the French national TAVI registry, FRANCE 2. We compared the clinical outcome of enrolled patients divided broadly into three groups according to the frequency of previous acute PO episode; group 1: no-episode, group 2: single-episode, and group 3: multiple-episodes within the year preceding TAVI.
  
  
  RESULTS
  Of the 3195 patients (mean age: 82.7 ± 7.2 years, mean logistic-EuroSCORE: 21.8 ± 14.3) with TAVI, 1880 (58.8%) had no-episode, 937 (29.3%) had single-episode, and 378 (11.9%) had multiple-episode. Both 30-day and cumulative 1-year mortality increased significantly across the 3 groups (7.7% vs. 9.2% vs. 15.9%; p<0.001, 14.0% vs. 19.4% vs. 24.1%; p<0.001, respectively). In addition, single-PO was not independently associated with an increased mortality at 30-day and 1-year compared to no-PO (HR: 0.99; 95% CI: 0.75-1.30; p=0.923, HR: 1.15; 95% CI: 0.94-1.39; p=0.173, respectively). In contrast multiple-PO was independently associated with an increased risk of both 30-day and cumulative 1-year mortality (HR: 1.51; 95% CI: 1.10-2.01; p=0.012, HR: 1.30; 95% CI: 1.01-1.66; p=0.043, respectively).
  
  
  CONCLUSIONS
  Multiple-PO, but not single, within the year preceding the index procedure is independently associated with increased mortality at short- and mid-term follow up after TAVI.
authors: CardiologyDepartment HôpitalHenri-Mondor, Assistance-Publique-HôpitauxdeParis & INSERM-U955, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France; Advanced Cardiovascular Therapy Unit, Cardiovascular Surgery Department, Ageo Central General Hospital, 1-10-10 Kashiwaza, Ageo, 362-8588 Saitama, Japan. Electronic address: frtakr@gmail.com.
authors: Akira
authors: A
authors: Furuta
authors: CardiologyDepartment HôpitalHenri-Mondor, Assistance-Publique-HôpitauxdeParis & INSERM-U955, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France.
authors: Nicolas
authors: N
authors: Lellouche
authors: CardiologyDepartment HôpitalHenri-Mondor, Assistance-Publique-HôpitauxdeParis & INSERM-U955, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France.
authors: Gauthier
authors: G
authors: Mouillet
authors: Cardiology Department, Centre-Hospitalier-Universitaire de Brest, Hôpital de la Cavale- Blanche, boulevard Tanguy Prigent, 29609 Brest, France.
authors: Martine
authors: M
authors: Gilard
authors: Cardiac Surgery Unit, Centre-Hospitalier-Universitaire de Limoges, 2 avenue Martin Luther king, 87042 Limoges Cedex, France.
authors: Marc
authors: M
authors: Laskar
authors: Cardiology Department, Centre-Hospitalier-Universitaire de Rouen, 1 rue de Germont, Rouen, France.
authors: Helene
authors: H
authors: Eltchaninoff
authors: Cardiology Department, Clinique Pasteur, Centre de recherche cardiologique, 1 rue de la petite vitesse, 31000 Toulouse, France.
authors: Jean
authors: J
authors: Fajadet
authors: Cardiology Department, Centre-Hospitalier-Universitaire Xavier Bichat, Université Paris Diderot, 16 rue Henri-Huchard, 75018 Paris, France.
authors: Bernard
authors: B
authors: Iung
authors: Cardiac Surgery Unit, Institut-Cardiovasculaire Paris-Sud, Massy, France.
authors: Patrick
authors: P
authors: Donzeau-Gouge
authors: Cardiac Surgery Unit, Centre-Hospitalier-Universitaire Pitié salpêtrière, Université Paris, France.
authors: Pascal
authors: P
authors: Leprince
authors: CHU Rennes, Rennes, France, 2 rue Henri le Guilloux, Rennes, France.
authors: Alain
authors: A
authors: Leuguerrier
authors: Cardiac Surgery Unit, Centre-Hospitalier-Universitaire de Lille, 12 rue Jean Jaurès, Lille, France.
authors: Alain
authors: A
authors: Prat
authors: CardiologyDepartment HôpitalHenri-Mondor, Assistance-Publique-HôpitauxdeParis & INSERM-U955, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France.
authors: Jean-Luc
authors: JL
authors: Dubois-Rande
authors: CardiologyDepartment HôpitalHenri-Mondor, Assistance-Publique-HôpitauxdeParis & INSERM-U955, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France.
authors: Emmanuel
authors: E
authors: Teiger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D011654:Pulmonary Edema / Q000150:complications*; D012042:Registries; D065467:Transcatheter Aortic Valve Replacement / Q000401:mortality*
keywords: Prognosis; Pulmonary oedema; Transcatheter aortic valve implantation