title: Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a malignant tumor. The morbidity and mortality of HCC tend to ascend and become a serious threat to the population health. Genetic studies of HCC have identified several susceptibility loci of HCC. In this study, we aim to replicate the association of these loci in our samples from Chinese population and further investigate the genetic interaction. We selected 16 SNPs within 1p36.22, 2q32.2-q32.3, 3p21.33, 8p12, 14q32.11 and 21q21.3 and genotyped in 507 HCC patients and 3014 controls by using Sequenom MassARRAY system. Association analyses were performed by using PLINK 1.07. We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study. In 3p21.33, genetic variant rs6795737 within GLB1 was also observed with suggestive evidence (P=9.98×10(-3), OR=0.84). In the interaction analysis, the pair of associated SNPs (rs7574865 within STAT4, rs8013403 within EFCAB11) generated evidence for interaction (P=4.10×10(-3)). In summary, our work first reported the association of 14q32.11 (EFCAB11) with HCC in Chinese Han population and revealed the genetic interaction between STAT4 (2q32.2-q32.3) and EFCAB11 (14q32.11) in HCC.
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Wei
authors: W
authors: Chen
authors: Department of Radiology, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Mingquan
authors: M
authors: Wang
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Zhen
authors: Z
authors: Zhang
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Huayang
authors: H
authors: Tang
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Xianbo
authors: X
authors: Zuo
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Xiangling
authors: X
authors: Meng
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Maoming
authors: M
authors: Xiong
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Fusheng
authors: F
authors: Zhou
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Bo
authors: B
authors: Liang
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Fen
authors: F
authors: Dai
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Jun
authors: J
authors: Fang
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Jinping
authors: J
authors: Gao
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
authors: Jun
authors: J
authors: Zhu
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Yong
authors: Y
authors: Zhu
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Hong
authors: H
authors: Wan
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Miaofeng
authors: M
authors: Wang
authors: Department of General Surgery, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
authors: Shixin
authors: S
authors: Chan
authors: The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China. Electronic address: ahmusld@163.com.
authors: Liangdan
authors: L
authors: Sun
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics; D050797:STAT4 Transcription Factor / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; C000598699:EFCAB11 protein, human; D012333:RNA, Messenger; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human
keywords: Genetics; Hepatocellular carcinoma; Polymorphism