title: MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene.
abstract: Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect.
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany. Electronic address: slutz@mpipsykl.mpg.de.
authors: S
authors: S
authors: Nischwitz
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: C
authors: C
authors: Wolf
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: T F M
authors: TF
authors: Andlauer
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: D
authors: D
authors: Czamara
authors: Department of Neurology, University of Rostock, Gehlsheimer Straße 20, 18147 Rostock, Germany.
authors: U K
authors: UK
authors: Zettl
authors: Department of Neurology, Sozialstiftung Bamberg, Buger Straße 80, 96049 Bamberg, Germany.
authors: P
authors: P
authors: Rieckmann
authors: Department of Neurology, TU München, Ismaninger Str. 22, 81675 München, Germany.
authors: D
authors: D
authors: Buck
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: M
authors: M
authors: Ising
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: T
authors: T
authors: Bettecken
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: B
authors: B
authors: Mueller-Myhsok
authors: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
authors: F
authors: F
authors: Weber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: GWAS; Imputation; MMP9; Multiple sclerosis; Susceptibility