title: Restorative treatment strategies for patients with cleidocranial dysplasia.
abstract: OBJECTIVE
  To develop a suitable treatment strategy for patients with cleidocranial dysplasia (CCD) who miss the optimal early treatment stage.
  
  
  METHODS
  This study enrolled 15 patients with CCD who had all missed the optimal treatment stage and were diagnosed with CCD through clinical examinations and genetic tests. Based on the chief complaints and requirements of the patients, three different therapeutic schedules were devised for these patients. Schedules I (periodontal and endodontic treatments) and II (periodontal, endodontic and prosthodontic treatments) were used for patients with low requirements, whereas Schedule III (multidisciplinary strategy, including periodontal, endodontic, surgical, orthodontic and prosthodontic treatments) was used for patients with high requirements.
  
  
  RESULTS
  Schedules I, II and III were used in five, seven and three patients, respectively. Schedule III treatments produced the best outcomes in terms of occlusion and esthetics.
  
  
  CONCLUSIONS
  Schedule III based on a comprehensive multidisciplinary therapy is an ideal restorative therapeutic strategy and can achieve good outcomes for patients with CCD who missed the optimal treatment stage.
authors: Department of Prosthodontics.
authors: Huaiguang
authors: H
authors: Chang
authors: Jiahui
authors: J
authors: Wei
authors: Ying
authors: Y
authors: Wang
authors: Jing
authors: J
authors: Jia
authors: Xuemei
authors: X
authors: Gao
authors: Xiaotong
authors: X
authors: Li
authors: Hailan
authors: H
authors: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002973:Cleidocranial Dysplasia / Q000601:surgery / Q000628:therapy*; D002985:Clinical Protocols; D003766:Dental Occlusion; D017266:Dental Prosthesis; D004955:Esthetics, Dental; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures; D009971:Orthodontics, Corrective; D010347:Patient Care Planning; D010348:Patient Care Team; D010510:Periodontal Diseases / Q000628:therapy; D012189:Retrospective Studies; D012390:Root Canal Therapy / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
keywords: RUNX2; cleidocranial dysplasia; multidisciplinary treatment; supernumerary teeth