title: Impact of anaesthetic technique on survival in colon cancer: a review of the literature.
abstract: An oncological surgical resection is the mainstay of treatment for potentially curable colon cancer. At the time of surgery, a large fraction of patients do harbour-although not visibly-minimal residual disease at the time of surgery. The immunosuppression that accompanies surgery may have an effect on disease recurrence and survival. Regional or neuraxial anaesthetic techniques like epidural anaesthesia may suppress immune function less than opioid analgesia, by reducing stress response and significantly reducing exposure to opioids. Consistent with this hypothesis, regional anaesthetic techniques have been associated with lower recurrence rates in breast cancer and prostate cancer. Results for colon cancer, however, are contradictory. In this review of the literature we describe all studies addressing the association of the use of epidural anaesthesia and survival in colon cancer surgery.
authors: Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands Department of Surgery, VieCuri Medical Centre, Venlo, the Netherlands.
authors: F Jeroen
authors: FJ
authors: Vogelaar
authors: Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
authors: Daan J
authors: DJ
authors: Lips
authors: Department of Anaesthesiology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.
authors: Frank R C
authors: FR
authors: van Dorsten
authors: Department of Research, Netherlands Cancer Registry/Comprehensive Cancer Organisation The Netherlands, Eindhoven, the Netherlands Department of Public Health, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.
authors: Valery E
authors: VE
authors: Lemmens
authors: Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands k.bosscha@jbz.nl k.bosscha@live.nl.
authors: Koop
authors: K
authors: Bosscha
keywords: colon cancer; epidural anaesthesia; immunosuppression; survival