title: A review of the pharmacology of carbonic anhydrase inhibitors for the treatment of glaucoma in dogs and cats.
abstract: Glaucoma is a heterogeneous group of disorders usually associated with elevated intraocular pressure (IOP), leading to optic nerve damage, retinal ganglion cell death and irreversible vision loss. Therefore, medications that lower IOP are the mainstay of glaucoma therapy. Carbonic anhydrase inhibitors (CAIs) are some of the principal drugs used in the management of canine and feline glaucoma. This paper summarises current knowledge of the mechanism of action of these agents and their effect on IOP in dogs and cats. It also discusses potential harmful side effects of CAIs and presents current opinions about their role and place in the medical management of glaucoma in small animals.
authors: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Street 13, 10-718 Olsztyn, Poland. Electronic address: tomasz.maslanka@uwm.edu.pl.
authors: Tomasz
authors: T
authors: Maślanka
mesh_terms: D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005901:Glaucoma / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D002257:Carbonic Anhydrase Inhibitors
keywords: Canine; Carbonic anhydrase inhibitors; Feline; Glaucoma; Intraocular pressure