title: Pd(0)-catalyzed intramolecular α-arylation of sulfones: domino reactions in the synthesis of functionalized tetrahydroisoquinolines.
abstract: A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.
authors: Laboratori de Química Orgànica, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona (Spain). dsole@ub.edu.
authors: Daniel
authors: D
authors: Solé
authors: Ferran
authors: F
authors: Pérez-Janer
authors: Raffaella
authors: R
authors: Mancuso
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D013450:Sulfones; D044005:Tetrahydroisoquinolines; D010165:Palladium
keywords: arylation; domino reactions; nitrogen heterocycles; palladium; sulfones