title: Infused autograft lymphocyte to monocyte ratio predicts survival in classical Hodgkin lymphoma.
abstract: The infused autograft lymphocyte to monocyte ratio (A-LMR) as a surrogate marker of host immunity (ie, absolute lymphocyte count) and CD14+ HLA-DR(low/neg) immunosuppressive monocytes (ie, absolute monocyte count) is a prognostic factor for patients with diffuse large B-cell lymphoma after autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if A-LMR can also affect survival post-APHSCT in classical Hodgkin lymphoma. From 1994 to 2012, 183 patients with classical Hodgkin lymphoma who underwent APHSCT were studied. The patients were randomly divided into a training set (n=122) and a validation set (n=61). The receiver operating characteristic and area under the curve identified an A-LMR ≥1 as the best cut-off value and validated by the k-fold cross-validation in the training set. Multivariate analysis showed A-LMR to be an independent prognostic factor for survival in the training set. Patients with an A-LMR ≥1.0 experienced a superior overall survival (OS) versus patients with an A-LMR <1.0 (median OS not reached versus 40.4 months, 5-year OS rates of 86% [95% CI 72-93] versus 43% [95% CI 28-58], P<0.0001, respectively) in the training set. In the validation set, an A-LMR ≥1 showed a median OS of not reached versus 41.4 months for an A-LMR <1, 5-year OS rates of 90% (95% CI 73-97) versus 48% (95% CI 28-68; P<0.0001). A-LMR provides a platform to engineer an autograft versus tumor effect to improve clinical outcomes in patients with classical Hodgkin lymphoma undergoing APHSCT.
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Luis F
authors: LF
authors: Porrata
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: David J
authors: DJ
authors: Inwards
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Stephen M
authors: SM
authors: Ansell
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Ivana N
authors: IN
authors: Micallef
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Patrick B
authors: PB
authors: Johnston
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: William J
authors: WJ
authors: Hogan
authors: Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Svetomir N
authors: SN
authors: Markovic
keywords: autograft absolute lymphocyte to monocyte count ratio; autologous peripheral hematopoietic stem cell transplantation; classical Hodgkin lymphoma; survival