title: The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients.
abstract: The ABCB1 gene encodes the P-glycoprotein (P-gp) that drives the transmembrane efflux of many drugs. The donor ABCB1 polymorphisms have been related with chronic histological damage and long-term renal function among kidney transplanted patients who received cyclosporine A and tacrolimus (Tac). The aim of our study was to determine whether the donor ABCB1 3435 C/T genotype was related with renal function among Tac-treated renal transplanted patients. Kidney donors (n=65) and recipients (n=90) were genotyped for the ABCB1 rs1045642 (c.3435 C/T) and CYP3A5 rs776746 single-nucleotide polymorphisms. The estimated glomerular filtration rate (eGFR) was calculated with the modification of diet in renal disease formulae at five post-transplant times (2 weeks and 1, 3, 6 and 12 months). The recipient ABCB1 and CYP3A5 genotypes had no significant effect on the eGFR at all the post-transplant times. We found significantly lower eGFR values among patients who received a kidney from ABCB1 3435 T carriers (P<0.01). In conclusion, our study confirmed the potential impact of the donor ABCB1 3435 genotype on the post-transplant renal function among patients treated with Tac.
authors: Genética Molecular- Fundación Renal I. Alvarez de Toledo, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
authors: Beatriz
authors: B
authors: Tavira
authors: Genética Molecular- Fundación Renal I. Alvarez de Toledo, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
authors: Juan
authors: J
authors: Gómez
authors: 1] Nefrología, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain [2] Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain [3] Red de Investigación Renal-REDINREN, Madrid, Spain.
authors: Carmen
authors: C
authors: Díaz-Corte
authors: Nefrología, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
authors: Diego
authors: D
authors: Coronel
authors: 1] Red de Investigación Renal-REDINREN, Madrid, Spain [2] Inmunología, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
authors: Carlos
authors: C
authors: Lopez-Larrea
authors: Laboratorio de Biología Celular de la Enfermedad Renal-Instituto de Investigacion Sanitaria F. Jiménez Diaz-Universidad Autónoma Madrid, Madrid, Spain.
authors: Beatriz
authors: B
authors: Suarez
authors: 1] Genética Molecular- Fundación Renal I. Alvarez de Toledo, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain [2] Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain [3] Red de Investigación Renal-REDINREN, Madrid, Spain.
authors: Eliecer
authors: E
authors: Coto
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000368:Aged; D005260:Female; D056726:Genetic Association Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016559:Tacrolimus / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D007166:Immunosuppressive Agents; D016559:Tacrolimus