title: [Impact of genetic factors on severity of side effects of opioids in patients after major surgical interventions].
abstract: The rate of the opioids side effects (SE) occurrence, as well as their mutual connection with possible variants of a single-nucleotide polymorphism (SNP) of genes of a μ1-opioid receptor (OPRM1) 118A>G and catechol-O-methyltranspherase (COMT) 1947G>A were studied in patients after surgical interventions of large volumes in the first postoperative day the rate of the narcotic analgetics SE occurrence have constituted: nemesis--56%, vomiting--17%, dizziness--61%, cutaneous pruritis--17%. Occurrence of central SE of opioids may be caused by the SNP COMT 1947G>A genes: the sedation depth is two times more in the genes AA and GA carriers, in comparison with such in the gene GG carrier (p < 0.05). Gastrointestinal SE may be connected with genes SNP OPRM1 118A>G and COMT 1947G>A: the nemesis occurrence rate is more in the genes OPRM1 AG+GG, COMT GA and GG carriers (p < 0.05), vomiting--in 2,8 times more in the OPRM1 AG+GG genes carriers, than in the group OPRM1 AA (p < 0.05). The severity of cutaneous SE of opiates may be dependent on the variant of SNP COMT 1947G>A: in genotype GG the cutaneous pruritis rate is in 2.9 times more, than in the AA+GA group (p < 0.05).
authors: A V
authors: AV
authors: Boiarkina
authors: A L
authors: AL
authors: Potapov
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004244:Dizziness / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010146:Pain / Q000517:prevention & control; D020641:Polymorphism, Single Nucleotide; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D011537:Pruritus / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D017450:Receptors, Opioid, mu / Q000235:genetics*
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase