title: Definitive radiotherapy in locally advanced non-small cell lung cancer: dose and fractionation.
abstract: Definitive radiotherapy plays a major role in the treatment of locally advanced non-small cell lung cancer (LA NSCLC). After the impact of RT dose for lung cancer was established, a number of trials were structured with the aim of better local control and overall survival by either dose escalation or shortening the total treatment time through conventional/altered fractionation, even in combination with chemotherapy (CT) and other targeted agents. In spite of the increased number of these studies, the optimal dose or fractionation still remains to be determined. Another aspect questioned is the incorporation of these higher doses and shorter treatment times with chemotherapy or targeted agents. This review summarises the results of significant trials on dose and altered fractionation in the treatment of LA-NSCLC with an emphasis on possible future perspectives.
authors: Department of Radiation Oncology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
authors: Nergiz
authors: N
authors: Dağoğlu
authors: Department of Radiation Oncology, Liv Hospital, İstanbul, Turkey.
authors: Şule
authors: Ş
authors: Karaman
authors: Department of Radiation Oncology, Neolife Medical Center, İstanbul, Turkey.
authors: Alptekin
authors: A
authors: Arifoğlu
authors: Department of Radiation Oncology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
authors: Seden
authors: S
authors: Küçücük
authors: Department of Radiation Oncology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
authors: Ethem N
authors: EN
authors: Oral
keywords: Dose; fractionation; non-small cell lung cancer; radiotherapy