title: Clinical significance of neutrophil gelatinase-associated lipocalin in Crimean-Congo hemorrhagic Fever.
abstract: Neutrophil gelatinase-associated lipocalin (NGAL), which is an important prognostic marker for sepsis and inflammatory diseases, is mostly released from neutrophils. Crimean-Congo hemorrhagic fever (CCHF) patients are generally neutropenic. We aimed to investigate whether there is a change in serum NGAL level and to investigate its effect on the recovery time (RT) during the course of CCHF. A total of 40 CCHF patients (19 females and 21 males) and 34 healthy controls (17 females and 17 males) were included in the study. The serum NGAL level and biochemical and hematological parameters were checked. The NGAL level of CCHF patients was significantly higher than that of the healthy controls (P < 0.001). A multivariate analysis showed that the independent prognostic factor for the prediction of the RT is the NGAL level (odds ratio [OR] 0.3, 95% confidence interval [Cl] 0.1-0.4, P < 0.001). An elevated NGAL level was found to be associated with an increased RT in CCHF patients. The NGAL levels of CHHF patients might be elevated due to increased cytokine release, the presence of a tissue injury, and the release of immature neutrophils from the bone marrow into the peripheral stream. This may be a good prognostic factor in CHHF patients.
authors: Department of Infectious Disease, School of Medicine, Recep Tayyip Erdogan University, Islampasa Mahallesi, 53100 Rize, Turkey.
authors: Ayse
authors: A
authors: Erturk
authors: Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors: Erkan
authors: E
authors: Cure
authors: Department of Infectious Disease, School of Medicine, Ataturk University, Erzurum, Turkey.
authors: Emine
authors: E
authors: Parlak
authors: Department of Biochemistry, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors: Medine
authors: M
authors: Cumhur Cure
authors: Department of Endocrinology, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors: Serap
authors: S
authors: Baydur Sahin
authors: Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors: Suleyman
authors: S
authors: Yuce
mesh_terms: D000209:Acute-Phase Proteins; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000097:blood*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D016207:Cytokines; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins