title: CASP3 genetic variants and susceptibility to atrial fibrillation in Chinese Han population.
abstract: BACKGROUND
  Caspase-3 plays an important role in the initiation and maintenance of atrial fibrillation (AF), but little is known about the role of CASP3 variants in the susceptibility to atrial fibrillation (AF). The purpose of this study was to comprehensively investigate the association between common genetic variants of CASP3 gene and AF in Chinese Han population.
  
  
  RESULTS
  We investigated the association of five variants in CASP3 and the risk of AF in 889 AF patients and 1015 controls. The genotype distribution of the rs4647602 was significantly different between patients with AF and controls (p<0.001), and the A allele frequency was significantly higher in AF patients than in controls (61.0% vs 53.2%; p<0.001). Compared with CC genotype carriers, subjects with AA genotype had significantly increased susceptibility to AF (OR=1.84, p<0.001). Multivariable logistic regression analysis showed that the rs4647602 polymorphism was significantly associated with risk of AF under dominant, recessive and additive genetic model (OR, 1.44-1.64; all p<0.001). There was no association between the other four SNPs (rs6948, rs2696056, rs4647602 and rs4647610) and risk of AF.
  
  
  CONCLUSIONS
  The rs4647602 polymorphism is independently associated with the risk of AF in Chinese Han population.
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Zhurong
authors: Z
authors: Luo
authors: Department of Cardiology, Shenyang General Hospital, Shenyang, China.
authors: Chenghui
authors: C
authors: Yan
authors: Department of Education, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Ping
authors: P
authors: Yu
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Weiwei
authors: W
authors: Bao
authors: Fujian Key Laboratory of Cardiovascular Disease, Fuzhou 350025, China.
authors: Xiaoli
authors: X
authors: Shen
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Weixing
authors: W
authors: Zheng
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Xianliang
authors: X
authors: Lin
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Zhiqing
authors: Z
authors: Wang
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Hao
authors: H
authors: Chen
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Fengping
authors: F
authors: Chen
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.
authors: Donglin
authors: D
authors: Liu
authors: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China. Electronic address: huangmf30@aliyun.com.
authors: Mingfang
authors: M
authors: Huang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology*; D001281:Atrial Fibrillation / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D053148:Caspase 3 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C505407:CASP3 protein, human; D053148:Caspase 3
keywords: Apoptosis; Atrial fibrillation; Caspase-3; Gene; Polymorphism