title: Interaction betweenGSTT1andGSTP1allele variants as a risk modulating-factor for autism spectrum disorders.
abstract: We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2-8 years of age from Jamaica to investigate the role ofGSTpi 1 (GSTP1),GSTtheta 1 (GSTT1), andGSTmu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status andGSTT1,GSTM1, orGSTP1genotype (allP> 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction betweenGSTP1andGSTT1in relation to ASD. Specifically, in children heterozygous for theGSTP1Ile105Val polymorphism, the odds of ASD was significantly higher in those with the nullGSTT1genotype than those with the other genotypes [Matched Odds Ratio (MOR) = 2.97, 95% CI (1.09, 8.01),P= 0.03]. Replication in other populations is warranted.
authors: Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, and Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, and Biostatistics/Epidemiology/Research Design (BERD) component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
authors: Mohammad H
authors: MH
authors: Rahbar
authors: Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
authors: Maureen
authors: M
authors: Samms-Vaughan
authors: Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, and Biostatistics/Epidemiology/Research Design (BERD) component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
authors: Jianzhong
authors: J
authors: Ma
authors: Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas 77030, USA.
authors: Jan
authors: J
authors: Bressler
authors: Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Houston, Texas 77054, USA.
authors: Katherine A
authors: KA
authors: Loveland
authors: Biostatistics/Epidemiology/Research Design component, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
authors: Manouchehr
authors: M
authors: Hessabi
authors: Biostatistics/Epidemiology/Research Design component, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
authors: Aisha S
authors: AS
authors: Dickerson
authors: Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas 77030, USA.
authors: Megan L
authors: ML
authors: Grove
authors: Department of Child & Adolescent Health, The University of West Indies, Mona Campus, Kingston, Jamaica.
authors: Sydonnie
authors: S
authors: Shakespeare-Pellington
authors: Department of Basic Medical Sciences, The University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Compton
authors: C
authors: Beecher
authors: Caribbean Genetics (CARIGEN), The University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Wayne
authors: W
authors: McLaughlin
authors: Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, and Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas 77030, USA.
authors: Eric
authors: E
authors: Boerwinkle
keywords: Autism spectrum disorder; Modulating-factor; Oxidative stress; gene-gene interaction; glutathione S-transferase (GST) genes