title: Examining the genetics of congenital facial paralysis--a closer look at Moebius syndrome.
abstract: OBJECTIVE
  The molecular underpinnings of Moebius syndrome (MBS) are diverse. This article provides a comprehensive summation of the genetic and etiologic literature underlying this disorder. Elucidating the genetic causes of the disorder can aid in earlier detection and treatment planning.
  
  
  METHODS
  Articles from 1880-2013 were selected and reviewed by six researchers to understand all of the molecular theories and chronicity of advancements in the literature.
  
  
  RESULTS
  Mutations in the MBS1, MBS2, and MBS3 gene loci all have contributed to the development of MBS through various pathways. HOX family genes coding for homeobox domains, also, have been implicated in the abnormal development of the human brain. These are among the numerous genes that have been linked to the development of MBS.
  
  
  CONCLUSIONS
  Our study codified nascent findings of the molecular determinants of MBS. These findings add to a growing database of MBS-associated mutations and can be used to diagnose MBS and clarify pathogenesis.
authors: Department of Otolaryngology-Head and Neck Surgery, New York Eye and Ear Infirmary-Mount Sinai Health System, 310 East 14th Street, 6th Floor, New York, NY, 10009, USA, skadakia@nyee.edu.
authors: Sameep
authors: S
authors: Kadakia
authors: Samuel N
authors: SN
authors: Helman
authors: Thomas
authors: T
authors: Schwedhelm
authors: Masoud
authors: M
authors: Saman
authors: Babak
authors: B
authors: Azizzadeh
mesh_terms: D004252:DNA Mutational Analysis; D056426:Genetic Loci / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D020331:Mobius Syndrome / Q000175:diagnosis / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins