title: [Indications for methotrexate in gynecology outside the first-line treatment of ectopic tubal pregnancies].
abstract: The objective of this work is to discuss the indications for methotrexate in gynecology outside the first-line treatment of tubal ectopic pregnancy. In tubal ectopic pregnancy, the prophylactic use of systemic methotrexate can be discussed when performing laparoscopic salpingotomy. In case of failure of salpingotomy, administration seems justified especially if it avoids re-intervention. The combination of methotrexate with other therapies such as mifepristone, potassium chloride or gefitinib is not recommended in the treatment of ectopic pregnancy. For non-tubal ectopic pregnancy, the intramuscular or local administration of methotrexate is an acceptable treatment for uncomplicated interstitial pregnancies. For uncomplicated cervical or cesarean scar pregnancies, the local administration of methotrexate should be considered as a first-line treatment. For ovarian pregnancies, methotrexate should not be a first-line treatment, surgical treatment remains the standard. Asymptomatic women presenting with a pregnancy of unknown location and plateauing serum hCG concentration<2000 UI/L can be managed expectantly: it is recommended to take an additional quantitative hCG serum level after 48 hours. Thus, methotrexate is not recommended in the first intention. Other gynecological indications were discussed: methotrexate is not recommended in the management of first-trimester miscarriages or in the management of placenta accreta.
authors: Service de gynécologie-obstétrique de l'hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grand rue de la Croix-rousse, 69004 Lyon, France. Electronic address: helene_misme@hotmail.com.
authors: H
authors: H
authors: Misme
authors: Service de gynécologie-obstétrique, CHU de La Conception, 147, boulevard Baille, 13385 Marseille cedex 05, France.
authors: A
authors: A
authors: Agostini
authors: Service de gynécologie-obstétrique de l'hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grand rue de la Croix-rousse, 69004 Lyon, France.
authors: G
authors: G
authors: Dubernard
authors: Service de gynécologie-obstétrique, CHU de La Conception, 147, boulevard Baille, 13385 Marseille cedex 05, France. Electronic address: clairemarie.tourette@ap-hm.fr.
authors: C
authors: C
authors: Tourette
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood / Q000188:drug therapy*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D008727:Methotrexate
keywords: Ectopic pregnancy; Fausse couche; Grossesse de localisation indéterminée; Grossesse ectopique; Methotrexate; Miscarriage; Méthotrexate; Placenta accreta; Pregancy of unknow location