title: PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke.
abstract: OBJECTIVE
  Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 gene variants on IS onset.
  
  
  METHODS
  A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls.
  
  
  RESULTS
  Statistically significant predictors of IS were male gender (OR 7.13, 95% CI 2.92-17.39, p<0.001), hypertension (OR 7.82. 95% CI 2.53-24.19, p<0.001), lowered HDL cholesterol (OR 8.20, 95% CI 2.41-27.94, p=0.001), elevated C-reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 -174 GC (OR 2.44 95% CI 1.01-5.91, p=0.0048) genotype. Males, compared to females, had 7 times higher odds for stroke. IL6 -174G/C genotype increased the odds for IS for 2.4 times. PPARγ was not statistically significantly associated with stroke.
  
  
  CONCLUSIONS
  We can point to the IL-6 -174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke.
authors: University Hospital Centre Zagreb, Department of Neurology, Neurological Intensive Care Unit, Zagreb, Croatia. Electronic address: antonelabazina@gmail.com.
authors: A
authors: A
authors: Bazina
authors: University of Zagreb School of Medicine, Zagreb, Croatia; University Hospital Centre Zagreb, Department of Laboratory Diagnosis, Clinical Unit of Molecular Diagnosis, Zagreb, Croatia. Electronic address: jadranka.sertic@kbc-zagreb.hr.
authors: J
authors: J
authors: Sertić
authors: University Hospital Centre Zagreb, Department of Neurology, Neurological Intensive Care Unit, Zagreb, Croatia. Electronic address: antonija.mismas@gmail.com.
authors: A
authors: A
authors: Mišmaš
authors: University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address: tena.lovric@vip.hr.
authors: T
authors: T
authors: Lovrić
authors: University Hospital Centre Zagreb, Department of Neurology, Neurological Intensive Care Unit, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address: zdravka.po@gmail.com.
authors: Z
authors: Z
authors: Poljaković
authors: University of Zagreb School of Medicine, Zagreb, Croatia; University Hospital Centre Zagreb, Clinic for Cardiovascular Diseases, Zagreb, Croatia. Electronic address: davor.milicic@mef.hr.
authors: D
authors: D
authors: Miličić
mesh_terms: D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D017523:Croatia; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D047495:PPAR gamma
keywords: Adults; Genes; Ischemic stroke; Polymorphisms