title: One-pot synthesis of 3,5-disubstituted and polysubstituted phenols from acyclic precursors.
abstract: A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.
authors: School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing 210094, China.
authors: Jinlong
authors: J
authors: Qian
authors: Wenbin
authors: W
authors: Yi
authors: Xin
authors: X
authors: Huang
authors: Yongbo
authors: Y
authors: Miao
authors: Junkai
authors: J
authors: Zhang
authors: Chun
authors: C
authors: Cai
authors: Wei
authors: W
authors: Zhang
mesh_terms: D002384:Catalysis; D004952:Esters; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004952:Esters; D007659:Ketones; D010636:Phenols