title: Heart rate variability in hypoxic ischemic encephalopathy: correlation with EEG grade and 2-y neurodevelopmental outcome.
abstract: BACKGROUND
  The study aims to describe heart rate variability (HRV) in neonatal hypoxic ischemic encephalopathy (HIE) and correlate HRV with electroencephalographic (EEG) grade of HIE and neurodevelopmental outcome.
  
  
  METHODS
  Multichannel EEG and electrocardiography (ECG) were assessed at 12-48 h after birth in healthy and encephalopathic full-term neonates. EEGs were graded (normal, mild, moderate, and severe). Neurodevelopmental outcome was assessed at 2 y of age. Seven HRV features were calculated using normalized-RR (NN) interval. The correlation of these features with EEG grade and outcome were measured using Spearman's correlation coefficient.
  
  
  RESULTS
  HRV was significantly associated with HIE severity (P < 0.05): standard deviation of NN interval (SDNN) (r = -0.62), triangular interpolation of NN interval histogram (TINN) (r = -0.65), mean NN interval (r = -0.48), and the very low frequency (VLF) (r = -0.60), low frequency (LF) (r = -0.67) and high frequency (HF) components of the NN interval (r = -0.60). SDNN at 24 and 48 h were significantly associated (P < 0.05) with neurodevelopmental outcome (r = -0.41 and -0.54, respectively).
  
  
  CONCLUSIONS
  HRV is associated with EEG grade of HIE and neurodevelopmental outcome. HRV has potential as a prognostic tool to complement EEG.
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
authors: Robert M
authors: RM
authors: Goulding
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
authors: Nathan J
authors: NJ
authors: Stevenson
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
authors: Deirdre M
authors: DM
authors: Murray
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
authors: Vicki
authors: V
authors: Livingstone
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
authors: Peter M
authors: PM
authors: Filan
authors: 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
authors: Geraldine B
authors: GB
authors: Boylan
mesh_terms: D001831:Body Temperature; D002657:Child Development; D002675:Child, Preschool; D004562:Electrocardiography; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology*; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome