title: Hepatocellular carcinoma in a large medical center of China over a 10-year period: evolving therapeutic option and improving survival.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is among the most common and lethal cancers worldwide, especially in China.
  
  
  METHODS
  We retrospectively analyzed data from patients who were diagnosed and treated HCC between 2002 and 2011 in a large hospital in northwest China and compared the data between periods 2002-2006 (P1) and 2007-2011 (P2).
  
  
  RESULTS
  2045 patients were included in analysis. The HCC stages at diagnosis according to the Barcelona clinic liver cancer staging system had no significant change. Treatment options of liver transplantation, transcatheter arterial chemoembolization and other therapy decreased while percutaneous local ablation and supportive care increased from P1 to P2. Options of surgical resection and systematic therapy had no significant change. Patient survival rates at 1, 3 and 5 years significantly improved from P1 to P2. The treatments with increasing option trend had a higher magnitude of survival increase and vise versa.
  
  
  CONCLUSIONS
  Over the last 10 years, the patient survival had a significant increase which was mainly a result of the optimal therapeutic selections according to disease stages in this center. However, the proportion of patients diagnosed at early stages of HCC remained low and did not increase, a result calling for implementing surveillance system for at risk patients.
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Qianqian
authors: Q
authors: Zhu
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Na
authors: N
authors: Li
authors: Department of Laboratory Medicine, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Xiaoyan
authors: X
authors: Zeng
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Qunying
authors: Q
authors: Han
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Fang
authors: F
authors: Li
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Cuiling
authors: C
authors: Yang
authors: Department of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.|Institute of Advanced Surgical Technology and Engineering, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Yi
authors: Y
authors: Lv
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Zhihua
authors: Z
authors: Zhou
authors: Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.|Institute of Advanced Surgical Technology and Engineering, Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.
authors: Zhengwen
authors: Z
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000628:therapy*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies