title: Dual emission channels for sensitive discrimination of Cys/Hcy and GSH in plasma and cells.
abstract: A new selective fluorescent and colorimetric chemosensor for the detection of GSH was developed. The discrimination of GSH from Cys and Hcy is achieved through two emission channel detection. The detection limit of probe 1 for GSH reached 10 nM (3 ppb). The excellent sensitivity and selectivity of probe 1 allow the selective detection of GSH over Cys and Hcy, which can be visualized colorimetrically and/or fluorescently. The sensitive detection of GSH allowed for convenient measurement of the GSH content in human plasma. The presence of GSH in cells was demonstrated through cell imaging.
authors: Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng, 475004, P. R. China. zhaow@henu.edu.cn.
authors: Yuanlin
authors: Y
authors: Zhang
authors: Xiangmin
authors: X
authors: Shao
authors: Yue
authors: Y
authors: Wang
authors: Fuchao
authors: F
authors: Pan
authors: Ruixue
authors: R
authors: Kang
authors: Fangfang
authors: F
authors: Peng
authors: Zhentao
authors: Z
authors: Huang
authors: Weijuan
authors: W
authors: Zhang
authors: Weili
authors: W
authors: Zhao
mesh_terms: D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003545:Cysteine / Q000097:blood / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006710:Homocysteine / Q000097:blood / Q000378:metabolism; D006801:Humans
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D006710:Homocysteine; D005978:Glutathione; D003545:Cysteine