title: Cradle of evil: osteogenic niche for early bone metastasis.
abstract: Bone metastasis often emerges long after the initial dissemination of cancer cells. In this issue of Cancer Cell, Wang and colleagues demonstrate that disseminated breast cancer cells engage osteogenic niches in the bone through heterotypic adherins junctions. This interaction activates mTOR signaling in cancer cells and supports their expansion to micrometastases.
authors: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
authors: Hanqiu
authors: H
authors: Zheng
authors: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.
authors: Yibin
authors: Y
authors: Kang
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D010012:Osteogenesis / Q000235:genetics*; D059016:Tumor Microenvironment / Q000235:genetics*