title: Enhanced biological activity of carotenoids stabilized by phenyl groups.
abstract: Carotenoids are lipid soluble food ingredients with multifunction including antioxidant and anticancer activities. However, carotenoids are destructively oxidized upon reaction with radicals resulting in toxic effects on biological systems. Two synthetic carotenoids (BAS and BTS) containing the aromatic phenyl groups with a para-substituent (OMe and Me, respectively) at C-13 and C-13' position were prepared in order to overcome a structural instability of carotenoid. Both BAS and BTS exerted stronger radical scavenging activity than β-carotene in DPPH and ABTS assays. In particular, BTS significantly reduced in vivo ROS (reactive oxygen species) levels and improved body growth and reproduction of Caenorhabditiselegans. BTS has a great potential for the advanced and modified carotenoid material with stability leading to enhanced bioavailability.
authors: Department of Energy and Biotechnology, Myongji University, Yongin 449-728, Republic of Korea.
authors: Ji Suk
authors: JS
authors: You
authors: Department of Nano Science and Engineering, Myongji University, Yongin 449-728, Republic of Korea.
authors: Sunhwa
authors: S
authors: Jeon
authors: Department of Energy and Biotechnology, Myongji University, Yongin 449-728, Republic of Korea.
authors: Youn Jung
authors: YJ
authors: Byun
authors: Department of Energy and Biotechnology, Myongji University, Yongin 449-728, Republic of Korea; Department of Nano Science and Engineering, Myongji University, Yongin 449-728, Republic of Korea; Department of Chemistry, Myongji University, Yongin 449-728, Republic of Korea. Electronic address: sangkoo@mju.ac.kr.
authors: Sangho
authors: S
authors: Koo
authors: Department of Energy and Biotechnology, Myongji University, Yongin 449-728, Republic of Korea; Department of Food and Nutrition, Myongji University, Yongin 449-728, Republic of Korea. Electronic address: sschoi@mju.ac.kr.
authors: Shin Sik
authors: SS
authors: Choi
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002338:Carotenoids
keywords: Antioxidant; C. elegans; Carotenoid; Phenyl group; ROS