title: Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization.
abstract: Vancomycin resistant Enterococcus (VRE) colonized patients are likely to receive VRE targeted Gram-positive antibiotics and may not be de-escalated appropriately once final cultures are available. A retrospective cohort study was conducted in VRE-colonized and non-VRE colonized patients with Enterococcal bloodstream infections. Of 101 patients (n = 50 VRE-colonized; n = 51 non-colonized), empiric therapy with linezolid or daptomycin was started more often in VRE-colonized than non-colonized patients (n = 8, 15.5% vs n = 27, 54%, p < 0.01). There was no difference in de-escalation once VRE infection was ruled out (non-colonized, n = 2, 66.7% vs VRE-colonized, n = 2, 50%, p = 0.09). This study encourages continued stewardship vigilance to decrease inappropriate antibiotic use.
authors: Department of Pharmacy, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 USA.
authors: Elizabeth
authors: E
authors: Short
authors: Department of Pharmacy, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 USA ; Department of Pharmacy Practice, Chicago State University College of Pharmacy, 9501 South King Dr, Chicago, IL 60628 USA.
authors: John
authors: J
authors: Esterly
authors: Department of Pharmacy, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 USA.
authors: Michael
authors: M
authors: Postelnick
authors: Chicago College of Pharmacy, Midwestern University, 555 31st St, Downers Grove, IL 60515 USA.
authors: Jeannie
authors: J
authors: Ong
authors: Department of Pharmacy, Northwestern Memorial Hospital, 251 E Huron St, Chicago, IL 60611 USA ; Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, 555 31st St, Downers Grove, Downers Grove, IL 60515 USA.
authors: Milena
authors: M
authors: McLaughlin
keywords: Daptomycin; De-escalation; Enterococcus; Linezolid; VRE; Vancomycin-resistant Enterococcus