title: Association between serum soluble corin and obesity in Chinese adults: a cross-sectional study.
abstract: OBJECTIVE
  Corin has been suggested to be associated with obesity by cell- and animal-based studies. However, the association has not yet been studied in populations. Here, the aim was to explore the association in a general population of China.
  
  
  METHODS
  This was a cross-sectional study. Data on demographic information, lifestyle risk factors, and personal medical history were collected; body mass index, waist circumference, and blood pressures were measured; and serum corin, blood lipids, and blood glucose were determined in 2498 participants aged above 30 years.
  
  
  RESULTS
  Log-transformed corin correlated to body mass index (r = 0.197, P < 0.001) and waist circumference (r = 0.289, P < 0.001). In the risk factor-adjusted analysis, compared with participants in the lowest quartile of serum corin, participants in the 4th quartile had significantly increased risk of prevalent overweight or obesity (OR = 2.26, 95% CI: 1.67-3.04) and central obesity (OR = 1.74, 95% CI: 1.30-2.34). ORs of overweight or obesity and central obesity positively and significantly increased with serum corin levels (P for trend < 0.001).
  
  
  CONCLUSIONS
  Serum soluble corin was significantly and positively associated with obesity. Our findings suggested that serum soluble corin may be a marker or risk factor for obesity.
authors: Center for Disease Prevention and Control of Gusu District, Suzhou, China; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
authors: Hao
authors: H
authors: Peng
authors: Qiu
authors: Q
authors: Zhang
authors: Hengshan
authors: H
authors: Shen
authors: Yan
authors: Y
authors: Liu
authors: Xiangqin
authors: X
authors: Chao
authors: Honggang
authors: H
authors: Tian
authors: Xiaoqin
authors: X
authors: Cai
authors: Jianhua
authors: J
authors: Jin
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism*; D056128:Obesity, Abdominal / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D015415:Biomarkers; C119812:CORIN protein, human; D012697:Serine Endopeptidases