title: Resolving bile reflux by lanreotide in patients with Roux-en-Y gastrojejunostomy.
abstract: Reflux into the esophagus after partial or total gastrectomy is a well known problem. Even a Roux-en-Y reconstruction is not always a definitive solution. Bile reflux might occur and cause disabling symptoms, unresponsive to the classic anti-acid or anti-reflux therapy. Endoscopy and a Tc-99m-BrIDA hepatobiliary (HIDA) scan can be used to make the diagnosis. Clinical studies have shown that lanreotide (somatuline), which strongly inhibits many gastro-intestinal hormones, reduces the bile salts outputs. We present a case of a patient with bile reflux after Roux-en-Y. After administration of lanreotide he had a good clinical improvement and mucosal healing on endoscopy. Lanreotide can be a good treatment option for bile reflux when classic treatment fails, but clinical trials with more patients will have to confirm this.
authors: K
authors: K
authors: Moubax
authors: F
authors: F
authors: Mana
authors: D
authors: D
authors: Urbain
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D015390:Gastric Bypass / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000209:etiology; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000601:surgery*
chemical_list: D006727:Hormone Antagonists; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin