title: Functional connectivity changes during a working memory task in rat via NMF analysis.
abstract: Working memory (WM) is necessary in higher cognition. The brain as a complex network is formed by interconnections among neurons. Connectivity results in neural dynamics to support cognition. The first aim is to investigate connectivity dynamics in medial prefrontal cortex (mPFC) networks during WM. As brain neural activity is sparse, the second aim is to find the intrinsic connectivity property in a feature space. Using multi-channel electrode recording techniques, spikes were simultaneously obtained from mPFC of rats that performed a Y-maze WM task. Continuous time series converted from spikes were embedded in a low-dimensional space by non-negative matrix factorization (NMF). mPFC network in original space was constructed by measuring connections among neurons. And the same network in NMF space was constructed by computing connectivity values between the extracted NMF components. Causal density (Cd) and global efficiency (E) were estimated to present the network property. The results showed that Cd and E significantly peaked in the interval right before the maze choice point in correct trials. However, the increase did not emerge in error trials. Additionally, Cd and E in two spaces displayed similar trends in correct trials. The difference was that the measures in NMF space were significantly greater than those in original space. Our findings indicated that the anticipatory changes in mPFC networks may have an effect on future WM behavioral choices. Moreover, the NMF analysis achieves a better characterization for a brain network.
authors: School of Biomedical Engineering, Tianjin Medical University Tianjin, China.
authors: Jing
authors: J
authors: Wei
authors: School of Biomedical Engineering, Tianjin Medical University Tianjin, China.
authors: Wenwen
authors: W
authors: Bai
authors: School of Biomedical Engineering, Tianjin Medical University Tianjin, China.
authors: Tiaotiao
authors: T
authors: Liu
authors: School of Biomedical Engineering, Tianjin Medical University Tianjin, China ; Research Center of Basic Medicine, Tianjin Medical University Tianjin, China.
authors: Xin
authors: X
authors: Tian
keywords: dimensionality reduction; functional connectivity; non-negative matrix factorization (NMF); spikes; working memory (WM)