title: Interleukin-17A in Legionella pneumonia: a retrospective study.
abstract: Interleukin (IL)-17A affects the immune system of the lung. Legionella infection can potentially lead to severe pneumonia. The present study aimed to evaluate the role of IL-17A in Legionella pneumonia. Serum IL-17A levels were quantified in both patients with Legionella pneumonia and control subjects; IL-17 was detected in sera from 4 out of 31 patients with Legionella pneumonia but in any controls. There were no differences in peripheral white blood cell counts or other serum biomarkers (C-reactive protein, and lactate dehydrogenase) between IL-17A-positive and IL-17A-negative patients. All IL-17A-positive patients in this cohort survived, where 8 of 27 IL-17A-negative patients did not. IL-17A was detected in available bronchoalveolar (BA) fluid samples from 7 patients with Legionella pneumonia within our cohort. However, the IL-17A and IFN-γ concentrations in BA fluids did not correlate with each other. IL-17A might play a significant role in some cases of Legionella pneumonia.
authors: Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus.
authors: Futoshi
authors: F
authors: Higa
authors: Attiya
authors: A
authors: Haroon
authors: Yoshikazu
authors: Y
authors: Iha
authors: Daisuke
authors: D
authors: Tasato
authors: Hideta
authors: H
authors: Nakamura
authors: Takeshi
authors: T
authors: Kinjo
authors: Maki
authors: M
authors: Tamayose
authors: Makoto
authors: M
authors: Furugen
authors: Kazuya
authors: K
authors: Miyagi
authors: Shusaku
authors: S
authors: Haranaga
authors: Masao
authors: M
authors: Tateyama
authors: Jiro
authors: J
authors: Fujita
mesh_terms: D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D016952:Legionella pneumophila / Q000276:immunology*; D007877:Legionnaires' Disease / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17