title: Withanolides with antibacterial activity from Nicandra john-tyleriana.
abstract: Eleven new withanolides (1-11) were isolated and characterized from the aerial parts of Nicandra john-tyleriana. Five of these withanolides have an unmodified skeleton (1-5), two are acnistins (6, 7), and four are withajardins (8-11). These new isolates were fully characterized using a combination of spectroscopic techniques (including multidimensional NMR) and mass spectrometry. All compounds were evaluated for their antibacterial activity against Bacillus, Enterococcus, Escherichia, Listeria, Pseudomonas, and Staphylococcus strains.
authors: Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba , Casilla de Correo 495, 5000 Córdoba, Argentina.
authors: Fátima
authors: F
authors: Gutiérrez Nicolás
authors: Guadalupe
authors: G
authors: Reyes
authors: Marcela C
authors: MC
authors: Audisio
authors: María L
authors: ML
authors: Uriburu
authors: Segundo
authors: S
authors: Leiva González
authors: Gloria E
authors: GE
authors: Barboza
authors: Viviana E
authors: VE
authors: Nicotra
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D016983:Enterococcus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008087:Listeria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010568:Peru; D035261:Plant Components, Aerial / Q000737:chemistry; D011549:Pseudomonas / Q000187:drug effects; D019657:Solanaceae / Q000737:chemistry*; D013210:Staphylococcus / Q000187:drug effects; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D054358:Withanolides