title: The oral disposition index is a strong predictor of incident diabetes in Asian Indian prediabetic men.
abstract: OBJECTIVE
  In this analysis, we sought to examine the prospective association of the disposition index (DIo) derived from oral glucose tolerance test with incident diabetes in Asian Indian men with impaired glucose tolerance (IGT).
  
  
  METHODS
  These post hoc analyses used data from a 2-year prospective study in primary prevention of diabetes using lifestyle intervention among 517 men with IGT. All the participants received standard lifestyle advice at baseline. The surrogate insulin sensitivity and insulin secretion measures were tested for their hyperbolic relationship. Predictive associations of various surrogate measures with incident diabetes were determined using receiver operating characteristic curves.
  
  
  RESULTS
  The combination of total area under the curve of insulin-to-glucose ratio (AUCinsulin/glucose) and Matsuda's insulin sensitivity index was the best equation to depict DIo [β: -0.954 (95 % CI -1.015 to -0.893)] compared to other measures tested in this cohort. There was an inverse association between change in DIo at the final follow-up and development of incident diabetes. Among the surrogate insulin measures studied, DIo [AUC (0.717 (95 % CI 0.675-0.756))] as a composite measure was superior than other surrogate indices.
  
  
  CONCLUSIONS
  Among the surrogate indices studied, DIo was the best measure associated with incident diabetes.
authors: India Diabetes Research Foundation, Dr. A. Ramachandran's Diabetes Hospitals, 28 Marshalls Road, Egmore, Chennai, 600008, India.
authors: Jagannathan
authors: J
authors: Ram
authors: Chamukuttan
authors: C
authors: Snehalatha
authors: Sundaram
authors: S
authors: Selvam
authors: Arun
authors: A
authors: Nanditha
authors: Ananth Samith
authors: AS
authors: Shetty
authors: Ian F
authors: IF
authors: Godsland
authors: Desmond G
authors: DG
authors: Johnston
authors: Ambady
authors: A
authors: Ramachandran
mesh_terms: D000284:Administration, Oral; D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D037001:Directive Counseling; D018450:Disease Progression; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics; D018149:Glucose Intolerance / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006305:Health Status Indicators; D006801:Humans; D007194:India / Q000453:epidemiology; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000453:epidemiology*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D060145:Text Messaging
chemical_list: D007328:Insulin; D005947:Glucose