title: Toxicological screening of Daouri, a polyherbal formulation used in children in the Central Region of Togo.
abstract: BACKGROUND
  Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the toxicity of individual plants. The present investigation aims to study the composition and potential toxicity of Daouri used in children in the Kotokoli community.
  
  
  METHODS
  Surveys were performed using a semi-structured questionnaire to determine the composition of Daouri. On the basis of these data collected, Standard Daouri was formulated, and its aqueous extract was orally administered at 300, 600 and 1200mg/kg to rats for 28 days. On the 29th day, the rats were sacrificed and their serum were analysed to evaluate hepatic and renal toxicities.
  
  
  RESULTS
  Four categories of Daouri were collected. The plant combinations used in each Daouri formulation varied according to the pathological conditions, including the age of the children and the availability of each plant. The most plants cited in the four Daouri were Khaya senegalensis (Desv.) A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. & Diels. Although there was an increase in the alkaline phosphatase concentration, different doses of the aqueous extract of Standard Daouri were not toxic after 28 days of administration. In addition, the concentrations of alanine transaminase, creatinine and urea were not different between the Daouri-treated and control groups.
  
  
  CONCLUSIONS
  Daouri is plant combination used in children in the Kotokoli community as a part of African Traditional Medicine. Standard Daouri is not toxic in rats.
authors: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo.
authors: Mawutodji S
authors: MS
authors: Edorh
authors: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo.
authors: Sadikou
authors: S
authors: Agbere
authors: Department of Chemistry, University of Ghana, Legon, Accra.P. O. Box LG56, Accra, Ghana.
authors: Dorcas
authors: D
authors: Osei-Safo
authors: Faulté des Sciences de la Santé, Université de Lomé, Togo.
authors: Zakilatou
authors: Z
authors: Adam
authors: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo. Electronic address: aamegnona3@gmail.com.
authors: Amegnona
authors: A
authors: Agbonon
authors: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo.
authors: Damintoti S
authors: DS
authors: Karou
authors: Faulté des Sciences de la Santé, Université de Lomé, Togo; Service de Pédiatrie du CHU Sylvanus Olympio, Lomé, Togo.
authors: Rahamane A
authors: RA
authors: Agbere
authors: Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, Togo.
authors: Messanvi
authors: M
authors: Gbeassor
mesh_terms: D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D019684:Magnoliopsida / Q000633:toxicity*; D008297:Male; D016488:Medicine, African Traditional; D028321:Plant Preparations / Q000032:analysis / Q000633:toxicity*; D010946:Plants, Medicinal / Q000633:toxicity; D017208:Rats, Wistar; D014037:Togo
chemical_list: D028321:Plant Preparations
keywords: Children health; Polyherbal; Toxicity; Traditional medicine