title: Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population.
abstract: Genetic variants of cholesteryl ester transfer protein (CETP) and endothelial nitric oxide synthase (eNOS) influence high-density lipoprotein cholesterol (HDL-C) metabolism and nitric oxide (NO) synthesis, respectively, and might increase the risk of coronary artery disease (CAD). This study is to investigate the relationship between genetic polymorphisms and the risk of CAD and to evaluate their potential interactions. A total of 237 patients with CAD and 101 controls were genotyped. The association of the polymorphism with the risk of CAD varied among the ethnic groups. Moreover, the concomitant presence of both CETP B1 and eNOS 4a alleles significantly increased the risk of CAD in the Malay group (OR = 33.8, P < .001) and the Indian group (OR = 10.9, P = .031) but not in the Chinese group. This study has identified a novel ethnic-specific gene-gene interaction and suggested that the combination of CETP B1 allele and eNOS 4a allele significantly increases the risk of CAD in Malays and Indians.
authors: Department of Biomedical Science, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia.
authors: Wern Cui
authors: WC
authors: Chu
authors: Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, Selangor, Malaysia Department of Medicine, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia Department of Cardiology, Hospital Serdang, Selangor, Malaysia.
authors: Ahmad Fazli Abdul
authors: AF
authors: Aziz
authors: Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, Selangor, Malaysia.
authors: Abdul Jalil
authors: AJ
authors: Nordin
authors: Department of Biomedical Science, Faculty of Medicine and Health Science, University Putra Malaysia, Selangor, Malaysia Centre for Diagnostic Nuclear Imaging, University Putra Malaysia, Selangor, Malaysia ykcheah@upm.edu.my.
authors: Yoke Kqueen
authors: YK
authors: Cheah
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D006801:Humans; D008296:Malaysia / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: CETP; Malaysian; coronary artery disease; eNOS; gene–gene interactions