title: Novel vanadyl complexes of alginate saccharides: synthesis, characterization, and biological activities.
abstract: Vanadium compounds present many physiological functions. However, vanadium(IV) and (V) salts are difficult for gastrointestinal absorption and have strong side effects. Therefore organic oxovanadium compounds gain more attention. Vanadyl alginate polysaccharides (VAPS) and vanadyl alginate oligosaccharides (VAOS) were obtained from aqueous solutions of VOSO4 at pH 12. They were characterized by infrared spectroscopy, UV-vis spectroscopy and inductively coupled plasma-mass spectrometry (ICP-MS). The antioxidant activity of oxovanadium(IV) complexes was investigated in hydroxyl and DPPH radical scavenging systems in vitro. The results reveal that activities of VAPS and VAOS in the two systems were stronger than those of alginate polysaccharides (APS) and alginate oligosaccharides (AOS), respectively. In addition, VAPS and VAOS promoted significantly the antiproliferation of ligands of human hepatoma cell line BEL-7402. Oxovanadium(IV) complexes were potent inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the range of 6.4-18.7μg/mL, indicated in biochemical assays. In addition, Vanadyl-alginate had no significant side effects on proliferation and viability of HL-7702 hepatic cells. In the future, they can be added to medicines and ease the growing threat that cancer and diabetes mellitus cause to human health.
authors: Yantai Institute of Coastal Zone Research Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Shengyi
authors: S
authors: Liu
authors: Yantai Institute of Coastal Zone Research Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Guangyang
authors: G
authors: Liu
authors: Yantai Institute of Coastal Zone Research Chinese Academy of Sciences, Yantai 264003, China. Electronic address: yiyuetao@gmail.com.
authors: Yuetao
authors: Y
authors: Yi
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D007328:Insulin / Q000378:metabolism; D008970:Molecular Weight; D009844:Oligosaccharides / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects; D014639:Vanadium / Q000737:chemistry*
chemical_list: D000464:Alginates; D001713:Biphenyl Compounds; D006603:Hexuronic Acids; D007328:Insulin; D009844:Oligosaccharides; D009942:Organometallic Compounds; D010851:Picrates; D014639:Vanadium; D017665:Hydroxyl Radical; D020723:Glucuronic Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Alginate (PubChem CID: 70678572); Antioxidant activity; Antiproliferative activity; Cytocompatibility; DPPH (PubChem CID: 2735032); Hydroxyl radical (PubChem CID: 961); Protein tyrosine phosphatase 1B; Sodium alginate (PubChem CID: 6850754); Sulforhodamine B (PubChem CID: 9916275); Vanadium (PubChem CID: 23990); Vanadyl alginate oligosaccharides; Vanadyl alginate polysaccharides; Vanadyl sulfate (PubChem CID: 34007); p-Nitrophenol phosphate (PubChem CID: 255)