title: Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters.
abstract: BACKGROUND
  Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters.
  
  
  METHODS
  Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens.
  
  
  RESULTS
  A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor.
  
  
  CONCLUSIONS
  This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.
authors: Medical College, Qingdao University, Qingdao, China E-mail : liangjun818@126.com.
authors: Zhong
authors: Z
authors: Liu
authors: Xin-Mei
authors: XM
authors: Wang
authors: Tong-Fu
authors: TF
authors: Jia
authors: Yi
authors: Y
authors: Zhai
authors: Ling-Yan
authors: LY
authors: Sun
authors: Yu-Ping
authors: YP
authors: Cheng
authors: Yue-Min
authors: YM
authors: Zhang
authors: Shi-Hai
authors: SH
authors: Liu
authors: Jun
authors: J
authors: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; C099815:IER3 protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm