title: Association between TGF-β1 +869C/T polymorphism and fracture risk: a meta-analysis.
abstract: The association between TGF-β1 +869C/T polymorphism and risk of fractures remained controversial. Therefore, we performed this meta-analysis to investigate this association. We searched PubMed, EMBASE, and Wangfang databases for studies before Aug 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. A total of ten studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was associated with a significantly increased risk of fracture (OR=1.41; 95% CI, 1.20-1.65; I(2) =0%). In the subgroup analysis according to gender, women was significantly associated with risk of fracture (OR=1.44; 95% CI, 1.20-1.73; I(2) =4%). In the subgroup analysis by race, Asians (OR=1.43; 95% CI, 1.06-1.92; I(2) =0%) and Caucasians (OR=1.44; 95% CI, 1.13-1.85; I(2) =15%) showed increased fracture risk. Our meta-analysis suggested that the TGF-β1 +869C/T polymorphism may be a risk factor for developing fracture.
authors: Department of Orthopedics, The Sixth People's Hospital affiliated to Shanghai Jiaotong University Shanghai 200233, China.
authors: Zhi-Chang
authors: ZC
authors: Zhang
authors: Department of Orthopedics, The Sixth People's Hospital affiliated to Shanghai Jiaotong University Shanghai 200233, China.
authors: Neng-Bin
authors: NB
authors: He
authors: Department of Orthopedics, The Sixth People's Hospital affiliated to Shanghai Jiaotong University Shanghai 200233, China.
authors: Tao
authors: T
authors: Zhang
keywords: Fracture; TGF-β1; meta-analysis; polymorphism