title: Palladium(II)-catalysed ortho-arylation of N-benzylpiperidines.
abstract: Pd(II)-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C-H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors: Peng Wen
authors: PW
authors: Tan
authors: Maxwell
authors: M
authors: Haughey
authors: Darren J
authors: DJ
authors: Dixon