title: Reliability of stool antigen tests: investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients.
abstract: BACKGROUND
  A diagnosis of H. pylori infection can be made by invasive or non-invasive methods. Several noninvasive diagnostic tests based on the detection of H. pylori stool antigen (HpSA) have been developed. The Genx H. pylori stool antigen card test is a new rapid, non-invasive test that is based on monoclonal immunochromatographic assay. The aim of this study was to determine its sensitivity, specificity, and diagnostic accuracy for diagnosing H. pylori infection in adult patients.
  
  
  METHODS
  A total of 162 patients were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive.
  
  
  RESULTS
  Using the reference test, 50.6% of the samples were positive for H. pylori infection. The Genx H. pylori antigen test was positive in 19.7% of patients. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the Genx H. pylori antigen test were 51.6%, 96.0%, 88.8%, 76.1%, and 79.0%, respectively.
  
  
  CONCLUSIONS
  The Genx H. pylori stool antigen card test is a new non-invasive method that is fast and simple to perform but provides less reliable results.
authors: Department of Internal Medicine, Division of Gastroenterology, Selcuk University, Selcuklu, Turkey E-mail : husein68@hotmail.com.
authors: Huseyin
authors: H
authors: Korkmaz
authors: Duygu
authors: D
authors: Findik
authors: Ceyha
authors: C
authors: Ugurluoglu
authors: Yuksel
authors: Y
authors: Terzi
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000032:analysis*; D001706:Biopsy; D019411:Clinical Laboratory Techniques; D004415:Dyspepsia / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D005243:Feces / Q000737:chemistry* / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results
chemical_list: D000942:Antigens, Bacterial