title: [Evaluation of genomic imbalance in endometrial hyperplasia and carcinoma].
abstract: OBJECTIVE
  The main goal of our study was to identify the earliest and specific genetic changes which could be associated with an increased risk of neoplastic transformation in a group of patients with endometrial hyperplasia. Another goal was to characterize genetic changes associated with advanced forms of cancer.
  
  
  METHODS
  The study involved forty-four (44) female patients, including five (5) patients with no histopathologically confirmed hyperplastic features, twenty-six (26) patients with histopathologically confirmed endometrial hyperplasia, and thirteen (13) patients with diagnosed carcinoma of the endometrium. The study was conducted using a custom-made 4x180 K microarray of BlueGnome.
  
  
  RESULTS
  Copy number variations (CNV) were found in the cases without endometrial hyperplasia. Such changes occur with varying frequency in the genome of healthy female population. Significant genome imbalance was identified in the twenty-six (26) (100%) patients with diagnosed hyperplasia and in eleven (11) subjects (84.6%) with diagnosed endometrial cancer. Other not yet reported, changes localized in characteristic regions of the genome were also found.
authors: Michal
authors: M
authors: Bednarek
authors: Maria
authors: M
authors: Constantinou
authors: Lukasz
authors: L
authors: Kqpczyfiskil
authors: Agata
authors: A
authors: Shiar Kassassir
authors: Anna
authors: A
authors: Sobczuk
authors: Maria
authors: M
authors: Wieszczycka
authors: Jacek
authors: J
authors: Suzin
authors: Bogdan
authors: B
authors: Kaluzewski
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D056915:DNA Copy Number Variations; D004714:Endometrial Hyperplasia / Q000235:genetics* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D023281:Genomics; D006801:Humans; D008875:Middle Aged