title: Increased serum sclerostin in postoperative biliary atresia.
abstract: BACKGROUND
  We determined the relationship between serum sclerostin and disease severity of biliary atresia (BA).
  
  
  METHODS
  Seventy postoperative BA patients and 35 controls were recruited. Serum sclerostin, C-terminal telopeptide of type I collagen (CTX), and osteocalcin were analyzed using ELISA. Bone mineral density (BMD) of the lumbar spine was measured by dual energy X-ray absorptiometry.
  
  
  RESULTS
  BA patients had significantly higher serum sclerostin than controls. Serum sclerostin was markedly elevated in jaundice patients compared with jaundice-free patients. Serum osteocalcin was not different, whereas serum CTX was greater in BA patients than controls. BMD of jaundice patients was significantly lower than jaundice-free patients. Additionally, serum sclerostin was correlated with biochemical parameters and BMD in BA.
  
  
  CONCLUSIONS
  Increased sclerostin levels were associated with liver dysfunction and the severity of BA, suggesting that sclerostin may reflect the deterioration of hepatic function and the outcome in postoperative BA.
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand. Electronic address: Sittisak.H@chula.ac.th.
authors: Sittisak
authors: S
authors: Honsawek
authors: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Wanvisa
authors: W
authors: Udomsinprasert
authors: Department of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Tawatchai
authors: T
authors: Chaiwatanarat
authors: Department of Surgery, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Paisarn
authors: P
authors: Vejchapipat
authors: Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Voranush
authors: V
authors: Chongsrisawat
authors: Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
authors: Yong
authors: Y
authors: Poovorawan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D001656:Biliary Atresia / Q000097:blood* / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D002648:Child; D024042:Collagen Type I / Q000737:chemistry; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011184:Postoperative Period
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D005819:Genetic Markers; D010446:Peptide Fragments; C422903:SOST protein, human; D015675:Osteocalcin
keywords: Biliary atresia; Bone mineral density; CTX; Jaundice; Osteocalcin; Sclerostin