title: [Whole brain radiation therapy for brain metastases: Advantages and controversies].
abstract: Whole brain radiation therapy is the angular stone of the brain metastasis radiation therapy. This treatment allows reaching two goals, potentially curative for in place metastasis and prophylactic in the rest of brain tissue. However, these two advantages can be disputed and in light of the same data opposite conclusions could be drawn.
authors: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Fédération de médecine translationnelle de Strasbourg (FMTS), laboratoire EA 3430, faculté de médecine, université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors: G
authors: G
authors: Noël
authors: Service d'oncologie-radiothérapie, institut Paoli-Calmette, 232, boulevard Sainte-Marguerite, BP 156, 13273 Marseille cedex 9, France.
authors: A
authors: A
authors: Tallet
authors: Département de radiothérapie, centre Georges-François-Leclerc, 1, rue du Professeur-Marion, BP 77980, 21079 Dijon cedex, France.
authors: G
authors: G
authors: Truc
authors: Département de radiothérapie, centre Alexis-Vautrin, avenue de Bourgogne, 54500 Vandœuvre-lès-Nancy, France.
authors: V
authors: V
authors: Bernier
authors: Service de radiothérapie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 49-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
authors: L
authors: L
authors: Feuvret
authors: Service de radiothérapie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 49-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Service de radiothérapie, centre clinique de la porte-de-Saint-Cloud, 30, rue de Paris, 92100 Boulogne-Billancourt, France.
authors: A
authors: A
authors: Assouline
authors: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Fédération de médecine translationnelle de Strasbourg (FMTS), laboratoire EA 3430, faculté de médecine, université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France.
authors: D
authors: D
authors: Antoni
authors: Service de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 392, 63011 Clermont-Ferrand cedex 1, France; Laboratoire EA 7283 Cancer Resistance Exploring and Targeting (CREaT), université d'Auvergne, 49, boulevard François-Mitterrand, 63000 Clermont-Ferrand, France.
authors: P
authors: P
authors: Verrelle
authors: Service de radiothérapie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 49-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
authors: J-J
authors: JJ
authors: Mazeron
authors: Département de radiothérapie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France.
authors: F
authors: F
authors: Mornex
authors: Institut de cancérologie Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France.
authors: F
authors: F
authors: Dhermain
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000505:Alopecia / Q000209:etiology; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000188:drug therapy / Q000517:prevention & control / Q000532:radiotherapy / Q000556:secondary*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008569:Memory Disorders / Q000209:etiology; D015337:Multicenter Studies as Topic; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D011838:Radiation-Sensitizing Agents
keywords: Brain metastases; Curative treatment; Guidelines; Irradiation encéphalique en totalité; Métastases cérébrales; Prophylactic treatment; Référentiel; Traitement curatif; Traitement prophylactique; Whole brain radiation therapy