title: Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.
abstract: Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestinal polyps in Apc (Min/+) mice, which are a useful model to clarify the role of Peyer's patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed. Intestinal polyp formation significantly decreased, concomitant with an increase in Peyer's patches development (n = 12/group). In Aly (-/-) Apc (Min/+) mice (negative control; no Peyer's patches) there was no change in the amount of intestinal polyps (n = 10/group). Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array. Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. This study identified a relationship between levels of Peyer's patches and intestinal polyp formation, partly explained by the involvement of interleukin-17 production and β-catenin signaling in Apc (Min/+) mice.
authors: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.
authors: Kyoko
authors: K
authors: Fujimoto
authors: Division of Cancer Prevention Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Gen
authors: G
authors: Fujii
authors: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.
authors: Hitomi
authors: H
authors: Sakurai
authors: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.
authors: Hiroko
authors: H
authors: Yoshitome
authors: Division of Cancer Prevention Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Michihiro
authors: M
authors: Mutoh
authors: Division of Molecular Biology, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo-shi, Nagasaki 859-3298, Japan.
authors: Morimasa
authors: M
authors: Wada
keywords: ApcMin/+ mouse; Peyer’s patch; cancer prevention; corn husk arabinoxylan; intestinal polyp