title: Manganese-catalyzed synthesis of cis-β-amino acid esters through organometallic C-H activation of ketimines.
abstract: Manganese-catalyzed CH functionalization reactions of ketimines set the stage for the expedient synthesis of cis-β-amino acid esters through site- and regioselective alkene annulations. The organometallic CH activation occurred efficiently with high functional group tolerance, delivering densely functionalized β-amino acid derivatives with ample scope.
authors: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/
authors: Weiping
authors: W
authors: Liu
authors: Daniel
authors: D
authors: Zell
authors: Michael
authors: M
authors: John
authors: Lutz
authors: L
authors: Ackermann
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004952:Esters; D007097:Imines; D007659:Ketones; D009942:Organometallic Compounds; D008345:Manganese
keywords: CH activation; amino acids; manganese; reaction mechanisms; selectivity