title: Association of thiol/disulfide ratio with syntax score in patients with NSTEMI.
abstract: OBJECTIVE
  The aim of this study was to investigate the relation between native thiol/disulfide ratio (TDR) and severity of coronary atherosclerosis as assessed by the Syntax score (SXscore) in patients with non-ST elevation myocardial infarction (NSTEMI) who underwent coronary angiography.
  
  
  METHODS
  A total of 290 patients with NSTEMI who underwent coronary angiography, were included in the study between January and August 2014. Baseline coronary angiography determined the SXscore. The patients were divided into two groups: one with low SXscores (< 23) and the other with high SXscores (≥ 23).
  
  
  RESULTS
  TDR was significantly lower in patients with high SXscores (p < 0.001). In-hospital mortality was higher in the group with low TDR and high SXscores. The cut-off value of TDR on admission that predicted a high SXscore in the groups combined was 14, with a sensitivity of 73% and a specificity of 68%.
  
  
  CONCLUSIONS
  TDR can be determined by an easy, inexpensive, automated, or optionally manual spectrophotometric assay, and correlates inversely with SXscore in patients with NSTEMI.
authors: Department of Cardiology, Ankara Numune Education and Research Hospital , Ankara , Turkey.
authors: Harun
authors: H
authors: Kundi
authors: Özcan
authors: Ö
authors: Erel
authors: Ahmet
authors: A
authors: Balun
authors: Hülya
authors: H
authors: Çiçekçioğlu
authors: Mustafa
authors: M
authors: Cetin
authors: Emrullah
authors: E
authors: Kiziltunç
authors: Salim
authors: S
authors: Neşelioğlu
authors: Canan
authors: C
authors: Topçuoğlu
authors: Ender
authors: E
authors: Örnek
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging* / Q000401:mortality; D018384:Oxidative Stress / Q000502:physiology*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D013438:Sulfhydryl Compounds
keywords: non ST elevation myocardial infarction; oxidative stress; syntax score; thiol to disulfide ratio