title: Streptokinase for acute myocardial infarction in the elderly.
abstract: BACKGROUND
  Acute myocardial infarction is one of the leading causes of death in the elderly, however clinical data reveals a disproportionately lower use of thrombolytics because of fear of complications especially intracranial haemorrhage. Our objective was to evaluate the safety of most commonly used thrombolytic streptokinase in elderly patients presenting with acute myocardial infarction.
  
  
  METHODS
  This descriptive case series was conducted at Punjab Institute of Cardiology, Lahore from September to December 2012 (4 months). One hundred elderly patients presenting with acute myocardial infarction were randomly selected for the study keeping in view the inclusion and exclusion criteria. All patients were thrombolysed with streptokinase within 12 hours of onset of symptoms and were monitored and investigated for electrical, mechanical and biochemical complications.
  
  
  RESULTS
  Out of one hundred patients 77 (77%) were males gnd 23 (23%) were females. Mean age was 73.39±5.29 years. The two most common complications of streptokinase were hypotension (33%) and bleeding (19%). Major bleed occurred only in 3 (3%) patients. No patient developed intracranial haemorrhage. Other complications included arrhythmias (6%), allergic reactions (4%), raised LFTs (6%) and raised RFTs (7%). No patient died of streptokinase related complications.
  
  
  CONCLUSIONS
  Use of streptokinase for acute myocardial infarction should not be discouraged in the elderly.
authors: Azmat Ehsan
authors: AE
authors: Qureshi
authors: Nasir Ali
authors: NA
authors: Jafri
authors: Ahmed
authors: A
authors: Noeman
authors: Samra
authors: S
authors: Yasmin
authors: Hamid
authors: H
authors: Khalil
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D013300:Streptokinase / Q000009:adverse effects*
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase