title: Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report.
abstract: BACKGROUND
  The pathophysiology and appropriate pharmacological interventions for delusional infestation remain unknown.
  
  
  METHODS
  Here, we report a case of primary delusional infestation successfully treated with aripiprazole. We performed functional magnetic resonance imaging (fMRI) to investigate brain structures and functional modifications. Before antipsychotic treatment, pre- versus post-treatment fMRI images revealed a marked increase in brain activation in the supplementary motor area (SMA).
  
  
  CONCLUSIONS
  Our results highlight the efficacy and safety of aripiprazole in the treatment of delusional infestation and the possible role of SMA dysfunction in delusional infestation. Indeed, our results suggest that psychiatric improvement of delusional infestation is associated with normalization of brain activity, particularly in the SMA.
authors: Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France ; CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France.
authors: Laura
authors: L
authors: Ponson
authors: Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France.
authors: Frédéric
authors: F
authors: Andersson
authors: Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France ; CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France.
authors: Wissam
authors: W
authors: El-Hage
keywords: antipsychotics; fMRI; supplementary motor area