title: Transarterial chemoembolization: modalities, indication, and patient selection.
abstract: Transarterial chemoembolization (TACE) is the standard of care for patients with intermediate stage hepatocellular carcinoma (BCLC B). Further improvement of the use of TACE was the subject of intense clinical research over the past years. The introduction of DEB-TACE brought more technical standardization and reduction of TACE related toxicity. The use of dynamic radiologic response evaluation criteria (EASL, mRECIST), uncovered the prognostic significance of objective tumor response. Finally, new approaches for better patient selection for initial and subsequent TACE treatment schedules will limit the use of TACE to some extent but have the potential to improve outcome for patients at risk for TACE-induced harm.
authors: Department of Internal Medicine III, Division of Gastroenterology/Hepatology, Liver Cancer (HCC)-Study Group, Medical University Vienna, Austria. Electronic address: wolfgang.sieghart@meduniwien.ac.at.
authors: Wolfgang
authors: W
authors: Sieghart
authors: Department of Internal Medicine III, Division of Gastroenterology/Hepatology, Liver Cancer (HCC)-Study Group, Medical University Vienna, Austria.
authors: Florian
authors: F
authors: Hucke
authors: Department of Internal Medicine III, Division of Gastroenterology/Hepatology, Liver Cancer (HCC)-Study Group, Medical University Vienna, Austria. Electronic address: markus.peck@meduniwien.ac.at.
authors: Markus
authors: M
authors: Peck-Radosavljevic
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D011379:Prognosis; D011859:Radiography; D020379:Risk Adjustment
keywords: HCC; Hepatocellular carcinoma; Intermediate stage; Overall survival; Patient selection; Response; TACE; mRECIST