title: Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future.
abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease progression offers an opportunity for the early diagnosis and staging using a noninvasive imaging technique such as positron emission tomography (PET). Thus, PET imaging of NFTs not only holds promise as a diagnostic tool but also may enable the development of disease modifying therapeutics for AD. In this review, we focus on the structural diversity of tau PET tracers, the challenges related to the identification of high affinity and highly selective NFT ligands, and recent progress in the clinical development of tau PET radioligands.
authors: †Neuroscience Medicinal Chemistry, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors: Manuela
authors: M
authors: Ariza
authors: ‡Neuroscience Biomarkers, Janssen Research and Development, 3210 Merryfield Row, San Diego, California 92121, United States.
authors: Hartmuth C
authors: HC
authors: Kolb
authors: §Neuroscience Discovery Biology, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors: Dieder
authors: D
authors: Moechars
authors: †Neuroscience Medicinal Chemistry, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium.
authors: Frederik
authors: F
authors: Rombouts
authors: ∥Discovery Sciences, Janssen Research and Development, a Division of Janssen-Cilag, Jarama 75, 45007 Toledo, Spain.
authors: José Ignacio
authors: JI
authors: Andrés
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D000818:Animals; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals; D016875:tau Proteins