title: Efficient oxa-Diels-Alder/semipinacol rearrangement/aldol cascade reaction: short approach to polycyclic architectures.
abstract: A novel carbon electrophile induced intermolecular oxa-Diels-Alder/semipinacol rearrangement/aldol cascade reaction of allylic silyl ether with β,γ-unsaturated α-ketoester has been developed under the promotion of SnCl4. This highly efficient transformation enables the quick construction of polycyclic architectures with up to five contiguous stereogenic centers in a single operation with moderate to good yields as well as high diastereoselectivity and would provide versatile short approaches to frameworks and/or analogues of numerous biologically important polycyclic natural products.
authors: A State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors: Jin-Bao
authors: JB
authors: Peng
authors: Yue
authors: Y
authors: Qi
authors: Ze-Ran
authors: ZR
authors: Jing
authors: Shao-Hua
authors: SH
authors: Wang
authors: Yong-Qiang
authors: YQ
authors: Tu
authors: Dao-Yong
authors: DY
authors: Zhu
authors: Fu-Min
authors: FM
authors: Zhang