title: Palladium-Catalyzed Aryl C(sp(2))-H Bond Hydroxylation of 2-Arylpyridine Using TBHP as Oxidant.
abstract: An efficient synthesis of phenols via Pd-catalyzed, pyridyl-directed homogeneous hydroxylation of the aryl C-H bond was developed, in which tert-butyl hydroperoxide was used as the sole oxidant. The method had a broad group tolerance and was available for both electron-rich and electron-deficient substrates. The reaction of a series of 2-arylpyridine derivatives gave the ortho-hydroxylation products in moderate to good yields.
authors: Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, College of Chemistry and Materials Science, Nanjing Normal University , Nanjing 210097, China.
authors: Jiawei
authors: J
authors: Dong
authors: Ping
authors: P
authors: Liu
authors: Peipei
authors: P
authors: Sun