title: [Role of probiotics in obesity management].
abstract: Obesity is a major public health issue as it is related to several chronic disorders, including type-2 diabetes, high blood pressure, dyslipemia, cardiovascular diseases and cancer, among others. Novel research shows that the gut microbiota is involved in obesity and metabolic disorders, revealing that obese animal and human subjects have alterations in the composition of the gut microbiota compared to their lean counterparts. Moreover, it has been observed in germ-free mice that transplantation of the microbiota of either obese or lean mice influences body weight, suggesting that the gut ecosystem is a relevant target for weight management. Certain strains of probiotics may regulate body weight by influencing the host's metabolic, neuroendocrine and immune functions. Taken together, our knowledge about the influence of gut microbiota on obesity is progressing. Therefore, modulation of its composition through probiotics may provide new opportunities to manage overweight and obesity.
authors: Grupo de Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC). España..
authors: Andreu
authors: A
authors: Prados-Bo
authors: Grupo de Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC). España..
authors: Sonia
authors: S
authors: Gómez-Martínez
authors: Grupo de Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC). España..
authors: Esther
authors: E
authors: Nova
authors: Grupo de Inmunonutrición, Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC). España.. amarcos@ictan.csic.es.
authors: Ascensión
authors: A
authors: Marcos
mesh_terms: D000818:Animals; D019468:Disease Management; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D064307:Microbiota; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D019936:Probiotics / Q000627:therapeutic use*