title: Crystal-induced acute kidney injury due to ciprofloxacin.
abstract: BACKGROUND
  Fluoroquinolones are known to cause acute renal failure due to interstitial nephritis.
  
  
  METHODS
  Here we present an elderly woman who developed oliguric acute kidney injury (AKI) after receiving oral and intravenous ciprofloxacin in a 48-hour period. Recently, several case reports have been published in the literature regarding the presence of crystals in the urine sediment of patients treated with ciprofloxacin for different types of systemic infections. Ciprofloxacin crystals precipitate in alkaline urine and provoke renal failure through intra-tubular precipitation.
  
  
  CONCLUSIONS
  Conservative measures including intravenous hydration and avoidance of alkalinization of the urine can reverse this condition if applied in time.
authors: Division of nephrology and Hypertension, Allegheny General Hospital, Temple University School of Medicine, Pittsburgh, PA, USA.
authors: Mahboob
authors: M
authors: Khan
authors: Division of nephrology and Hypertension, Allegheny General Hospital, Temple University School of Medicine, Pittsburgh, PA, USA.
authors: Luis M
authors: LM
authors: Ortega
authors: Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, USA.
authors: Nasreen
authors: N
authors: Bagwan
authors: Division of Nephrology and Hypertension, University of Miami, Miami, FL, USA.
authors: Ali
authors: A
authors: Nayer
keywords: Acute kidney injury; Crystalluria; Fluoroquinolones; Interstitial nephritis