title: Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.
abstract: The development of CNS drugs is associated with high failure rates. It is postulated that too much focus has been put on BBB permeability and too little on understanding BBB transport, which is the main limiting factor in drug delivery to the brain. An integrated approach to collecting, understanding, and handling pharmacokinetic-pharmacodynamic information from early discovery stages to the clinic is therefore recommended in order to improve translation to human drug treatment.
authors: Leiden Academic Centre for Drug Research, Division of Pharmacology, Leiden University, Gorlaeus Laboratories, Leiden, The Netherlands.
authors: E C M
authors: EC
authors: de Lange
authors: M
authors: M
authors: Hammarlund-Udenaes
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism / Q000502:physiology*; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D057170:Translational Research, Biomedical
chemical_list: D002491:Central Nervous System Agents