title: Dyshomeostasis of Serum Oxidant/Antioxidant Status and Copper, Zinc, and Selenium Levels in Elderly Physically Disabled Persons: an AHAP-Based Study.
abstract: The percentage of elderly persons is rapidly growing. Physical disability is one of the main age-related diseases which affect life quality. There are some studies that suggest the oxidative stress and trace elements are involved in physical disability in elderly persons, but the results are inconclusive. Therefore, the aim of this study was to investigate the status of aforementioned parameters in elderly physically disabled patients vs. healthy ones. According to the Katz questionnaire form, 44 subjects with physical disability and 66 age-gender-matched healthy subjects were selected from Amirkola Health and Aging Project (AHAP). The results indicated that patient group had lower serum Zn, Se, and total antioxidant levels than the control group (p < 0.001), whereas serum total oxidant level and Cu to Zn ratio (CZr) were higher in control group than in healthy one (p < 0.001). A positive correlation was found between Zn, Se, total antioxidant, and bone mineral density of femur (BMD.F) with activities of daily living (ADL) score (p < 0.01); meanwhile, a negative correlation between CZr and total oxidant with ADL score was observed (p < 0.01). Serum total oxidant level and CZr index had the highest area under the curve in receiver operating characteristic (ROC) analysis among the included parameters for discrimination of physically disabled patients than the normal ones. Decrease in serum Zn and Se levels, low BMD, and increase in CZr and oxidative stress were observed in physically disabled patients. It seems that CZr is more reliable parameter than the others to discriminate the physically disabled patients than the healthy persons.
authors: Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran.
authors: Simin
authors: S
authors: Younesi
authors: Hadi
authors: H
authors: Parsian
authors: Seyed Reza
authors: SR
authors: Hosseini
authors: Hajighorban
authors: H
authors: Noreddini
authors: Abbas
authors: A
authors: Mosapour
authors: Ali
authors: A
authors: Bijani
authors: Sohrab
authors: S
authors: Halalkhor
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D015519:Bone Density / Q000502:physiology; D003300:Copper / Q000097:blood*; D006233:Persons with Disabilities; D005260:Female; D005269:Femur / Q000737:chemistry; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D012643:Selenium / Q000097:blood*; D014131:Trace Elements / Q000097:blood; D015032:Zinc / Q000097:blood*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D014131:Trace Elements; D003300:Copper; D012643:Selenium; D015032:Zinc