title: On-column enrichment and surface-enhanced Raman scattering detection in nanoparticles functionalized porous capillary monolith.
abstract: A monolithic column functionalized with gold nanoparticles (GNPs) was designed to provide ultrasensitive detection with surface-enhanced Raman scattering (SERS). The monolithic column based on poly (glycidyl methacrylate-co-ethylene dimethacrylate) (GMA-co-EDMA) was served as the enrichment sorbent to concentrate GNPs and targets. We found that 60 nm GNPs-functionalized monolithic columns demonstrated the best SERS enhancement, and the lowest detectable concentration for PATP and CV could be achieved at 10(-7) and 10(-11) M, respectively. Moreover, the columns exhibit a good reproducibility in both spot-to-spot (∼10%) and batch-to-batch (∼15%). The SERS monolithic column with a high sensitivity and reproducibility has a great potential in the field-based rapid detection of targets in complex real-world samples.
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Qian
authors: Q
authors: Jiang
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Tian
authors: T
authors: Zeng
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Song
authors: S
authors: Yang
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Qian
authors: Q
authors: Chen
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Lei
authors: L
authors: Chen
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China.
authors: Yong
authors: Y
authors: Ye
authors: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan 430062, P.R. China. Electronic address: zhouji@hubu.edu.cn.
authors: Ji
authors: J
authors: Zhou
authors: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P.R. China. Electronic address: xusp@jlu.edu.cn.
authors: Shuping
authors: S
authors: Xu
mesh_terms: D000327:Adsorption; D000814:Aniline Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008768:Methylmethacrylates / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D008768:Methylmethacrylates; D013438:Sulfhydryl Compounds; C020347:GMA-EDMA; D006046:Gold; C064316:4-aminothiophenol
keywords: Gold nanoparticles; On-column enrichment; Porous capillary monolith; SERS