title: MultimodalIn VivoSkin Imaging with Integrated Optical Coherence and Multiphoton Microscopy.
abstract: In this paper, we demonstrate high-resolution, multimodalin vivoimaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acquisition and coregistration. The system design and the OCM image processing architecture enable sufficient performance of both modalities forin vivoimaging of human skin. Examples of multimodalin vivoimaging are presented as well as time lapse imaging of blood flow in single capillary loops. By making use of multiple intrinsic contrast mechanisms this integrated technique improves the ability to noninvasively visualize living tissue. Integrated OCM and MPM has potential applications forin vivodiagnosis of various pathological skin conditions, such as skin cancer, as well as potential pharmaceutical and cosmetic research applications.
authors: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: Benedikt W
authors: BW
authors: Graf
authors: Departments of Electrical and Computer Engineering, Bioengineering, and Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
authors: Stephen A
authors: SA
authors: Boppart
keywords: In vivo imaging; multimodal microscopy; multiphoton microscopy (MPM); optical coherence tomography (OCT)