title: A novel graft material for preventing cerebrospinal fluid leakage in skull base reconstruction: technical note of perifascial areolar tissue.
abstract: Objectives Perifascial areolar tissue (PAT), a layer of loose connective tissue on the deep fascias with a rich vascular plexus, serves as a vital cover over defects with scarce vascularity. We report the usefulness of PAT as a nonvascularized alternative to flaps for reconstruction of dural defects in skull base surgery and transsphenoidal surgery while evaluating its effect on control of cerebrospinal fluid (CSF) leakage. Design A retrospective chart analysis was performed on patients who had undergone repair of a dural defect with PAT during skull base surgery or transsphenoidal surgery between December 2004 and October 2011. Results Twenty-one patients were included: 11 patients had received surgical treatment and/or irradiation. Fourteen of the 21 patients had pre- and/or intraoperative CSF leakage. Only one patient (4.8%) had postoperative CSF leakage requiring additional surgical repair. Ten patients underwent postoperative irradiation from 1 to 15 months after transplant of the PAT. None of the patients had postoperative CSF leakage after irradiation. Conclusion We successfully repaired dural defects using PAT in skull base surgery and transsphenoidal surgery, even in patients with a history of multiple operations and radiotherapy. PAT may serve as a valuable tool for skull base reconstruction.
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Nakamasa
authors: N
authors: Hayashi
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Koichi
authors: K
authors: Mitsuya
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Katsuya
authors: K
authors: Gorai
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Keita
authors: K
authors: Inoue
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Ichiro
authors: I
authors: Ito
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Masahiro
authors: M
authors: Nakagawa
authors: Divisions of Neurosurgery, Plastic and Reconstructive Surgery, and Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
authors: Yoko
authors: Y
authors: Nakasu
keywords: cerebrospinal fluid leakage; perifascial areolar tissue; skull base; transsphenoidal surgery