title: Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population.
abstract: BACKGROUND
  Susceptibility to aggressive periodontitis (AgP) is influenced by genetic as well as environmental factors. Studies linking gene variants to AgP have been mainly centred in developed countries with limited data from Africa.
  
  
  OBJECTIVE
  To investigate whether previously reported candidate gene associations with AgP could be replicated in a population from Sudan.
  
  
  METHODS
  The investigation was a case-control design. Cases with AgP (n = 132) and controls (n = 136) were identified from patients attending the Periodontal Department in Khartoum Dental Hospital. Genotyping was performed using the Sequenom MassARRAY iPLEX platform. Analysis focused on gene variants with a minor allele frequency (MAF) > 25% in the Sudanese subjects that had previously been reported to be associated with AgP.
  
  
  RESULTS
  One candidate gene rs1537415 (GLT6D1) was significantly associated with AgP, OR = 1.50 (95% CI 1.04-2.17), p = 0.0295 (increasing to p = 0.09 after correction for multiple testing). The association strengthened to OR = 1.56 (95% CI 1.15-2.16), p = 0.0042 when the controls were supplemented with data from the Hap map for the Yoruba in Ibadan (n = 147) and remained significant (p = 0.013) after correction for multiple testing.
  
  
  CONCLUSIONS
  The study independently replicated the finding that rs1537415, a variant in glycosyl transferase gene GLT6D1, is associated with AgP and provided the first report of genetic associations with AgP in a Sudanese population.
authors: Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.
authors: Nada T
authors: NT
authors: Hashim
authors: Gerard J
authors: GJ
authors: Linden
authors: Muntasir E
authors: ME
authors: Ibrahim
authors: Bakri G
authors: BG
authors: Gismalla
authors: Fionnuala T
authors: FT
authors: Lundy
authors: Francis J
authors: FJ
authors: Hughes
authors: Ikhlas A
authors: IA
authors: El Karim
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics*; D016301:Alveolar Bone Loss / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D016695:Glycosyltransferases / Q000235:genetics*; D060148:HapMap Project; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013397:Sudan; D055815:Young Adult
chemical_list: D016695:Glycosyltransferases
keywords: Africans; aggressive periodontitis; gene polymorphism