title: Psychotropic drug-associated electrocardiographic presentation of diffuse J-waves in hypothermia: case report and literature review.
abstract: The use of psychotropic drugs is often associated with electrocardiographic (ECG) QT-interval prolongation, but there are few reports of J-waves. This report describes the case of a schizophrenic patient under treatment with several psychotropic drugs (olanzapine, valproate, and flunitrazepam), in whom ECG J-waves diffusely appeared during a hypothermic episode. We further performed a literature review of psychotropic drug-related J-waves in hypothermia. The present case highlights the importance of recognizing psychotropic drug-related ECG J-waves on an early warning sign to ensure appropriate monitoring and/or treatment for possible life-threatening side effects of such medications.
authors: Department of Internal Medicine, Nishida Hospital, Tsuruoka-Nishi-Machi 2-266, Saiki, Oita, 876-0047, Japan. hkata@cream.plala.or.jp.
authors: Hajime
authors: H
authors: Kataoka
authors: Division of Pharmacy, Nishida Hospital, Oita, Japan.
authors: Hirofumi
authors: H
authors: Kajiwara
authors: Department of Internal Medicine, Nishida Hospital, Tsuruoka-Nishi-Machi 2-266, Saiki, Oita, 876-0047, Japan.
authors: Eiji
authors: E
authors: Yano
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D001833:Body Temperature Regulation / Q000187:drug effects*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents
keywords: Electrocardiogram; Flunitrazepam; Hypothermia; J-wave; Olanzapine; Osborn wave; Psychotropic drug; Valproate