title: Numerical resolution of a model of tumour growth.
abstract: We consider and solve numerically a mathematical model of tumour growth based on cancer stem cells (CSC) hypothesis with the aim of gaining some insight into the relation of different processes leading to exponential growth in solid tumours and into the evolution of different subpopulations of cells. The model consists of four hyperbolic equations of first order to describe the evolution of four subpopulations of cells. A fifth equation is introduced to model the evolution of the moving boundary. The coefficients of the model represent the rates at which reactions occur. In order to integrate numerically the four hyperbolic equations, a formulation in terms of the total derivatives is posed. A finite element discretization is applied to integrate the model equations in space. Our numerical results suggest the existence of a pseudo-equilibrium state reached at the early stage of the tumour, for which the fraction of CSC remains small. We include the study of the behaviour of the solutions for longer times and we obtain that the solutions to the system of partial differential equations stabilize to homogeneous steady states whose values depend only on the values of the parameters. We show that CSC may comprise different proportions of the tumour, becoming, in some cases, the predominant type of cells within the tumour. We also obtain that possible effective measure to detain tumour progression should combine the targeting of CSC with the targeting of progenitor cells.
authors: Department of Applied Mathematics, Rey Juan Carlos University, Tulipán Street, Móstoles, Madrid, E 28933, Spain.
authors: Ana I
authors: AI
authors: Muñoz
mesh_terms: D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms; D014411:Neoplastic Stem Cells
keywords: cancer stem cells; finite element methods; free boundary problems; numerical resolution; tumour evolution