title: Successful management of acute myeloid leukemia transformed from chronic myelomonocytic leukemia in the elderly by a combination regimen of decitabine and cytarabine, aclarubicin and granulocyte colony-stimulating factor: A case report.
abstract: Despite advances in the treatment of acute myeloid leukemia (AML) in recent years, the outcome of elderly AML patients with antecedent hematological disorders remains unsatisfactory. The present study describes a case of complete remission in an elderly patient with AML transformed from chronic myelomonocytic leukemia (CMML) and the treatment of the case with decitabine in combination with cytarabine, aclarubicin and granulocyte colony-stimulating factor (CAG). A 70-year-old male was admitted with fever, pruritus and weakness that had been apparent for two weeks, and a two-year history of monocytosis (22.5-27.0%). Further examinations revealed a hemoglobin level of 106 g/l, a white blood cell count of 39.52×109/l, a platelet count of 81×109/l, Y chromosome loss and uniparental disomy on chromosomes 4q, 2q and 19p. The patient was diagnosed with AML transformed from CMML, with cytogenetic anomalies. A combination regimen of decitabine and CAG was administered. Subsequent to one cycle, the patient achieved complete remission. The patient was then followed up with three courses of the same regimen and achieved clinical remission, with no evidence of AML relapse. The present study suggests that a combination of low-dose decitabine and CAG may offer a novel and potentially effective treatment regimen for elderly AML patients.
authors: Department of Hematology, The First Central Hospital of Tianjin, Tianjin 300192, P.R. China.
authors: Qi
authors: Q
authors: Deng
authors: Department of Hematology, The First Central Hospital of Tianjin, Tianjin 300192, P.R. China.
authors: Jing-Yi
authors: JY
authors: Li
authors: Department of Hematology, The First Central Hospital of Tianjin, Tianjin 300192, P.R. China.
authors: Peng-Jiang
authors: PJ
authors: Liu
authors: Department of Hematology, The First Central Hospital of Tianjin, Tianjin 300192, P.R. China.
authors: Ming-Feng
authors: MF
authors: Zhao
keywords: aclarubicin and granulocyte colony-stimulating factor; acute myeloid leukemia; chronic myeloid leukemia; cytarabine; decitabine; single nucleotide polymorphism