title: [Methotrexate pharmacology].
abstract: Methotrexate is a folic acid analog, which is a thymidylate synthetase and dihydrofolate reductase inhibitor. It is used in oncology, dermatology and rheumatology and off labelling in the treatment of ectopic pregnancies. This paper is a review of methotrexate pharmacology with focus on data concerning ectopic pregnancies.
authors: Centre régional de pharmacovigilance, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France. Electronic address: lalagarce@chu-angers.fr.
authors: L
authors: L
authors: Lagarce
authors: Centre régional de pharmacovigilance et d'informations sur les médicaments, CHU de Clermont-Ferrand, 58, rue Montalembert BP 69, 63003 Clermont-Ferrand, France; EA 4681 PEPRADE, université d'Auvergne, 63001 Auvergne, France.
authors: M
authors: M
authors: Zenut
authors: Centre régional de pharmacovigilance, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
authors: P
authors: P
authors: Lainé-Cessac
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate
keywords: Ectopic pregnancy; Grossesse extra-utérine; Methotrexate; Méthotrexate; Pharmacologie; Pharmacology