title: The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study.
abstract: BACKGROUND
  There are no previous data on the association of PNPLA3 I148M polymorphism (rs738409) with circulating adipokines and myokines in children.
  
  
  METHODS
  Subjects were a population sample of 481 Caucasian children aged 6-8 years. We assessed circulating levels of irisin together with IL-6, TNF-α, leptin, high molecular weight (HMW)-adiponectin, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) while the subjects were stratified according to PNPLA3 I148M variants.
  
  
  RESULTS
  The PNPLA3 rs738409 polymorphism had a linear relationship with plasma levels of irisin after adjustment for age, sex and body height (p=0.007) but it was not associated with circulating levels of interleukin- 6 (IL-6), tumor-necrosis factor α (TNF-α), leptin or HMW-adiponectin.
  
  
  CONCLUSIONS
  PNPLA3 148M allele carriers had higher plasma levels of irisin than the non-carriers. This might be due to compensatory mechanism to limit early steatotic and inflammatory changes in the liver.
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland; Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Electronic address: anna.viitasalo@uef.fi.
authors: Anna
authors: A
authors: Viitasalo
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors: Mustafa
authors: M
authors: Atalay
authors: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.
authors: Jussi
authors: J
authors: Pihlajamäki
authors: Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
authors: Jarmo
authors: J
authors: Jääskeläinen
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors: Ayhan
authors: A
authors: Korkmaz
authors: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.
authors: Dorota
authors: D
authors: Kaminska
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
authors: Virpi
authors: V
authors: Lindi
authors: Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
authors: Timo A
authors: TA
authors: Lakka
mesh_terms: D054392:Adipokines / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000483:Alleles; D002648:Child; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008049:Lipase / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D044465:White People / Q000235:genetics*; D005723:gamma-Glutamyltransferase / Q000097:blood; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D054392:Adipokines; D000410:Alanine Transaminase; D005353:Fibronectins; D015850:Interleukin-6; D020738:Leptin; D008049:Lipase; D008565:Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; D005723:gamma-Glutamyltransferase; C577593:FNDC5 protein, human; C508600:IL6 protein, human; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
keywords: Children; Irisin; PNPLA3