title: Renal blood flow using arterial spin labelling MRI and calculated filtration fraction in healthy adult kidney donors Pre-nephrectomy and post-nephrectomy.
abstract: OBJECTIVE
  Renal plasma flow (RPF) (derived from renal blood flow, RBF) and glomerular filtration rate (GFR) allow the determination of the filtration fraction (FF), which may have a role as a non-invasive renal biomarker. This is a hypothesis-generating pilot study assessing the effect of nephrectomy on renal function in healthy kidney donors.
  
  
  METHODS
  Eight living kidney donors underwent arterial spin labelling (ASL) magnetic resonance imaging (MRI) and GFR measurement prior to and 1 year after nephrectomy. Chromium-51 labelled ethylenediamine tetraacetic acid ((51)Cr-EDTA) with multi-blood sampling was undertaken and GFR calculated. The RBF and GFR obtained were used to calculate FF.
  
  
  RESULTS
  All donors showed an increase in single kidney GFR of 24 - 75 %, and all but two showed an increase in FF (-7 to +52 %) after nephrectomy. The increase in RBF, and hence RPF, post-nephrectomy was not as great as the increase in GFR in seven out of eight donors. As with any pilot study, the small number of donors and their relatively narrow age range are potential limiting factors.
  
  
  CONCLUSIONS
  The ability to measure RBF, and hence RPF, non-invasively, coupled with GFR measurement, allows calculation of FF, a biomarker that might provide a sensitive indicator of loss of renal reserve in potential donors.
  
  
  CONCLUSIONS
  • Non-invasive MRI measured renal blood flow and calculated renal plasma flow. • Effect of nephrectomy on blood flow and filtration in donors is presented. • Calculated filtration fraction may be a useful new kidney biomarker.
authors: Imaging and Biophysics Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N1EH, UK.
authors: Marica
authors: M
authors: Cutajar
authors: Rachel
authors: R
authors: Hilton
authors: Jonathon
authors: J
authors: Olsburgh
authors: Stephen D
authors: SD
authors: Marks
authors: David L
authors: DL
authors: Thomas
authors: Tina
authors: T
authors: Banks
authors: Christopher A
authors: CA
authors: Clark
authors: Isky
authors: I
authors: Gordon
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D065096:Calcium Chelating Agents / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000502:physiology; D019520:Living Donors; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009392:Nephrectomy; D010865:Pilot Projects; D011182:Postoperative Care; D011300:Preoperative Care; D012077:Renal Artery / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology*; D013113:Spin Labels
chemical_list: D015415:Biomarkers; D065096:Calcium Chelating Agents; D013113:Spin Labels; D004492:Edetic Acid