title: The effect of isotretinoin on ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with acne.
abstract: BACKGROUD/AIMS: Widely prescribed in routine practice, isotretinoin has an unknown impact on ovarian reserve. With a long history in acne treatment and numerous potential side effects, it is surprising that very few prospective studies have investigated its effect on ovarian reserve. Therefore, we aimed to evaluate the impact of oral isotretinoin on ovarian reserve based on hormonal parameters, anti-Müllerian hormone (AMH), ovarian volume (OV), and antral follicle count (AFC) in women of reproductive age with acne.
  
  
  METHODS
  Our study group consisted of 82 women of reproductive age with acne who were treated with oral isotretinoin. The patients were evaluated for ovarian reserve prior to therapy and reevaluated 6 months after isotretinoin treatment with regard to hormonal parameters, AMH, OV, and AFC.
  
  
  RESULTS
  Significant differences were found between the pre- and posttreatment period for AMH [2.20 ng/ml (25th-75th percentile 1.14-4.07) vs. 1.31 ng/ml (0.32-2.28)], total AFC [16 (14-18.25) vs. 12.5 (10-15)], and total OV [23 ml (18-29) vs. 15 ml (13-18); p < 0.001].
  
  
  CONCLUSIONS
  Our study is the first to analyze the levels of serum AMH, AFC, and OV together in patients treated with oral isotretinoin for acne. The results of our study demonstrated that oral isotretinoin had a significant negative effect on ovarian reserve.
authors: Department of Obstetrics and Gynecology, Kayseri Military Hospital, Kayseri, Turkey.
authors: Huseyin
authors: H
authors: Aksoy
authors: Levent
authors: L
authors: Cinar
authors: Gokhan
authors: G
authors: Acmaz
authors: Ulku
authors: U
authors: Aksoy
authors: Turgut
authors: T
authors: Aydin
authors: Umit Erkan
authors: UE
authors: Vurdem
authors: Leyla
authors: L
authors: Oz
authors: Ozge
authors: O
authors: Idem Karadag
authors: Demet
authors: D
authors: Kartal
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D006080:Ovarian Follicle / Q000187:drug effects; D065851:Ovarian Reserve / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D054304:Anti-Mullerian Hormone; D015474:Isotretinoin