title: Hedgehog: linking uracil to innate defense.
abstract: The ability of the gut epithelium to defend against pathogens while tolerating harmless commensal organisms remains an important puzzle. In this issue of Cell Host & Microbe, Lee et al. (2015) reveal how pathogen-secreted uracil acts at two steps to induce ROS via the Hedgehog pathway.
authors: Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA. Electronic address: ebier@ucsd.edu.
authors: Ethan
authors: E
authors: Bier
authors: Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0687, USA; Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0687, USA. Electronic address: vnizet@ucsd.edu.
authors: Victor
authors: V
authors: Nizet
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D004330:Drosophila / Q000382:microbiology*; D011992:Endosomes / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D014498:Uracil / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D014498:Uracil; D019255:NADPH Oxidases