title: Neural mechanisms underlying the therapeutic actions of guanfacine treatment in youth with ADHD: a pilot fMRI study.
abstract: Twenty-five youth with attention-deficit/hyperactivity disorder (ADHD) were scanned with functional magnetic resonance imaging (fMRI) while performing a Go/No-go task before and after 6-8 weeks of randomized once-daily treatment with either the α₂A-adrenergic receptor agonist guanfacine or placebo. Clinical improvement was greater for guanfacine than placebo and was differentially associated with reduced activation for guanfacine compared with placebo in the right midcingulate cortex/supplementary motor area and the left posterior cingulate cortex.
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Anne-Claude V
authors: AC
authors: Bédard
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: kurt.schulz@mssm.edu.
authors: Kurt P
authors: KP
authors: Schulz
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Beth
authors: B
authors: Krone
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Juan
authors: J
authors: Pedraza
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Stephanie
authors: S
authors: Duhoux
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychology, Queens College of the City University of New York, Flushing, NY, USA.
authors: Jeffrey M
authors: JM
authors: Halperin
authors: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Jeffrey H
authors: JH
authors: Newcorn
mesh_terms: D000293:Adolescent; D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D005260:Female; D016316:Guanfacine / Q000008:administration & dosage / Q000494:pharmacology*; D006179:Gyrus Cinguli / Q000187:drug effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000187:drug effects; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D016316:Guanfacine
keywords: ADHD; Guanfacine; fMRI