title: Revisiting tissue specificity of germline  cancer predisposing mutations.
abstract: Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?
authors: John M
authors: JM
authors: Maris
authors: Alfred G
authors: AG
authors: Knudson
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002648:Child; D016162:Genes, Wilms Tumor; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics; D009928:Organ Specificity / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics; D016160:Retinoblastoma Protein / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016160:Retinoblastoma Protein; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases