title: NiSO4-catalyzed C-H activation/C-S cross-coupling of 1,2,3-triazole N-oxides with thiols.
abstract: An efficient nickel-catalyzed protocol for C-S cross-coupling through the direct functionalization of 2-aryl-1,2,3-triazole N-oxide C-H bonds with aryl or alkyl thiols, or diphenyl disulfide has been developed. The targeted N(+)-O(-) bond cleavage can be observed during the reaction, and thus obviates the need to use an additional deoxygenation step. This new protocol for the preparation of thiolated 2-aryl-1,2,3-triazoles appears to offer good yields with high regioselectivity, mild conditions, and a wide substrate scope.
authors: Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, PR China. lxliu@xmu.edu.cn chenzwang@126.com.
authors: Jiayi
authors: J
authors: Zhu
authors: Yu
authors: Y
authors: Chen
authors: Feng
authors: F
authors: Lin
authors: Baoshuang
authors: B
authors: Wang
authors: Zhengwang
authors: Z
authors: Chen
authors: Liangxian
authors: L
authors: Liu
mesh_terms: D002384:Catalysis; D007554:Isotopes; D007700:Kinetics; D009532:Nickel / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D007554:Isotopes; D010087:Oxides; D013438:Sulfhydryl Compounds; D014230:Triazoles; C029938:nickel sulfate; D009532:Nickel