title: Chemical Complexity and the Genetics of Aging.
abstract: We examine how aging is impacted by various chemical challenges that organisms face and by the molecular mechanisms that have evolved to regulate lifespan in response to them. For example, environmental information, which is detected and processed through sensory systems, can modulate lifespan by providing information about the presence and quality of food as well as presence and density of conspecifics and predators. In addition, the diverse forms of molecular damage that result from constant exposure to damaging chemicals that are generated from the environment and from metabolism pose an informatic and energetic challenge for detoxification systems, which are important in ensuring longevity. Finally, systems of innate immunity are vital for recognizing and combating pathogens but are also seen as of increasing importance in causing the aging process. Integrating ideas of molecular mechanism with context derived from evolutionary considerations will lead to exciting new insights into the evolution of aging.
authors: Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 ; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
authors: Scott D
authors: SD
authors: Pletcher
authors: Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
authors: Hadise
authors: H
authors: Kabil
authors: Center for Research on Ageing, University College London, Darwin Building, Gower Street, London, WC1E6BT.
authors: Linda
authors: L
authors: Partridge
keywords: Aging; chemical complexity; evolutionary conservation; innate immunity; sensory perception; xenobiotic metabolism