title: Molecular evolution of cytochrome bd oxidases across proteobacterial genomes.
abstract: This work is aimed to resolve the complex molecular evolution of cytochrome bd ubiquinol oxidase, a nearly ubiquitous bacterial enzyme that is involved in redox balance and bioenergetics. Previous studies have created an unclear picture of bd oxidases phylogenesis without considering the existence of diverse types of bd oxidases. Integrated approaches of genomic and protein analysis focused on proteobacteria have generated a molecular classification of diverse types of bd oxidases, which produces a new scenario for interpreting their evolution. A duplication of the original gene cluster of bd oxidase might have occurred in the ancestors of extant α-proteobacteria of the Rhodospirillales order, such as Acidocella, from which the bd-I type of the oxidase might have diffused to other proteobacterial lineages. In contrast, the Cyanide-Insensitive Oxidase type may have differentiated into recognizable subtypes after another gene cluster duplication. These subtypes are widespread in the genomes of α-, β-, and γ-proteobacteria, with occasional instances of lateral gene transfer. In resolving the evolutionary pattern of proteobacterial bd oxidases, this work sheds new light on the basal taxa of α-proteobacteria from which the γ-proteobacterial lineage probably emerged.
authors: Italian Institute of Technology, Genoa, Italy mauro.degliesposti@iit.it.
authors: Mauro
authors: M
authors: Degli Esposti
authors: Center of Genomic Sciences, UNAM University, Cuernavaca, Mexico.
authors: Tania
authors: T
authors: Rosas-Pérez
authors: Center of Genomic Sciences, UNAM University, Cuernavaca, Mexico.
authors: Luis Eduardo
authors: LE
authors: Servín-Garcidueñas
authors: Center of Genomic Sciences, UNAM University, Cuernavaca, Mexico.
authors: Luis Manuel
authors: LM
authors: Bolaños
authors: Center of Genomic Sciences, UNAM University, Cuernavaca, Mexico.
authors: Monica
authors: M
authors: Rosenblueth
authors: Center of Genomic Sciences, UNAM University, Cuernavaca, Mexico.
authors: Esperanza
authors: E
authors: Martínez-Romero
mesh_terms: D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics*; D003580:Cytochromes / Q000145:classification / Q000235:genetics*; D003576:Electron Transport Complex IV; D019143:Evolution, Molecular; D020563:Gammaproteobacteria / Q000235:genetics; D022761:Gene Transfer, Horizontal; D016680:Genome, Bacterial; D005810:Multigene Family; D010088:Oxidoreductases / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D020560:Proteobacteria / Q000145:classification / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D003580:Cytochromes; D010088:Oxidoreductases; D003576:Electron Transport Complex IV
keywords: bacterial evolution; bioenergetics; cytochrome bd oxidase; proteobacteria