title: [Peptide receptor radionuclide therapy for patients with somatostatin receptor expressing tumours. German Guideline (S1)].
abstract: This document describes the guideline for peptide receptor radionuclide therapy (PRRT) published by the German Society of Nuclear Medicine (DGN) and accepted by the Association of the Scientific Medical Societies in Germany (AWMF) to be included in the official AWMF Guideline Registry. These recommendations are a prerequisite for the quality management in the treatment of patients with somatostatin receptor expressing tumours using PRRT. They are aimed at guiding nuclear medicine specialists in selecting likely candidates to receive PRRT and to deliver the treatment in a safe and effective manner. The recommendations are based on an interdisciplinary consensus. The document contains background information and definitions and covers the rationale, indications and contraindications for PRRT. Essential topics are the requirements for institutions performing the therapy, e. g. presence of an expert for medical physics, intense cooperation with all colleagues involved in the treatment of a patient, and a certificate of instruction in radiochemical labelling and quality control are required. Furthermore, it is specified which patient data have to be available prior to performance of therapy and how treatment has to be carried out technically. Here, quality control and documentation of labelling are of great importance. After treatment, clinical quality control is mandatory (work-up of therapy data and follow-up of patients). Essential elements of follow-up are specified in detail. The complete treatment inclusive after-care has to be realised in close cooperation with the involved medical disciplines. Generally, the decision for PRRT should be undertaken within the framework of a multi-disciplinary tumour board.
authors: Dr. Thorsten Pöppel, Universitätsklinikum Essen, Klinik für Nuklearmedizin, Hufelandstr. 55, 45122 Essen, Germany, E-mail: Thorsten.Poeppel@uk-essen.de.
authors: T D
authors: TD
authors: Poeppel
authors: C
authors: C
authors: Boy
authors: A
authors: A
authors: Bockisch
authors: J
authors: J
authors: Kotzerke
authors: I
authors: I
authors: Buchmann
authors: S
authors: S
authors: Ezziddin
authors: K
authors: K
authors: Scheidhauer
authors: B J
authors: BJ
authors: Krause
authors: D
authors: D
authors: Schmidt
authors: H
authors: H
authors: Amthauer
authors: F
authors: F
authors: Rösch
authors: J
authors: J
authors: Nagarajah
authors: D
authors: D
authors: Führer
authors: H
authors: H
authors: Lahner
authors: G
authors: G
authors: Pöpperl
authors: D
authors: D
authors: Hörsch
authors: M A
authors: MA
authors: Walter
authors: R P
authors: RP
authors: Baum
mesh_terms: D005858:Germany; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D010455:Peptides / Q000493:pharmacokinetics*; D017410:Practice Guidelines as Topic; D018787:Radiation Oncology / Q000592:standards*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017481:Receptors, Somatostatin / Q000378:metabolism*
chemical_list: D010455:Peptides; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin
keywords: DOTATATE; DOTATOC; NEN; NET; Neuroendocrine tumour; PRRT; guideline; peptide receptor radionuclide therapy