title: Increased plasma vaspin concentration in patients with sepsis: an exploratory examination.
abstract: BACKGROUND
  Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.
  
  
  METHODS
  57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P<0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r=0.31, P=0.002) as well as with SAPS II (r=0.34, P=0.002) and maximum of SOFA (r=0.39, P<0.001) scoring systems, as tested for the overall study population.
  
  
  CONCLUSIONS
  In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Michael C
authors: MC
authors: Motal
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Daniel A
authors: DA
authors: Klaus
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Diana
authors: D
authors: Lebherz-Eichinger
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Bianca
authors: B
authors: Tudor
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria.
authors: Thomas
authors: T
authors: Hamp
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria.
authors: Marion
authors: M
authors: Wiegele
authors: Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria.
authors: Rudolf
authors: R
authors: Seemann
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Claus G
authors: CG
authors: Krenn
authors: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria ; RAIC Laboratory 13C1, Medical University of Vienna, Vienna, Austria.
authors: Georg A
authors: GA
authors: Roth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood*; D015843:Serpins / Q000097:blood*
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins; D002097:C-Reactive Protein
keywords: CRP; adipocytokine; inflammation; intensive care; vaspin