title: Role of microRNAs in diagnosis and treatment of the pathogenesis of gastric cancer.
abstract: We aim to detect the miRNAs that are correlated with the gastric cancer cell line SGC-7901 to provide theoretical basis for clinical application. We first analyzed miRNA expression profiles of gastric cancer patients compared with normal controls by microarray analysis and validated the results by real-time qPCR. We also determined the absolute copy numbers of these three miRNAs in normal adults. The results showed that three miRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 gastric cancer patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased miRNAs were significant in clinical analysis. Generally speaking, this finding suggest vital roles of these miRNAs in human gastric cancer genesis and as potential biomarkers in gastric cancer diagnosis.
authors: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University Wuhan, China.
authors: Gang
authors: G
authors: Chen
authors: Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University Wuhan, China.
authors: Yong
authors: Y
authors: Tang
authors: Departments of Gynecological Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital Tianjin, China.
authors: Jiang-Hua
authors: JH
authors: Wu
authors: Departments of Gynecological Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital Tianjin, China.
authors: Feng-Hua
authors: FH
authors: Liu
keywords: SGC-7901; diagnosis biomarker; gastric cancer; microRNAs