title: Association between single nucleotide polymorphism of vitamin D receptor gene FokI polymorphism and clinical progress of benign prostatic hyperplasia.
abstract: BACKGROUND
  The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men.
  
  
  METHODS
  The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotypes of VDR gene FokI SNP represented by "F/f" were identified by PCR-restriction fragment length polymorphism. The odds ratio (OR) of having progression of BPH for having the genotype were calculated.
  
  
  RESULTS
  Our date indicated that the f alleles of the VDR gene FokI SNP associated with the progression of BPH (P = 0.009).
  
  
  CONCLUSIONS
  For the first time, our study demonstrated that VDR gene FokI SNP may be associated with the risk of BPH progress.
authors: Department of Urology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China.
authors: Li
authors: L
authors: Ruan
authors: Department of Urology, Guizhou Provincial People's Hospital, Guizhou 550002, China.
authors: Jian-guo
authors: JG
authors: Zhu
authors: Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, China.
authors: Cong
authors: C
authors: Pan
authors: Department of Pathology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China.
authors: Xing
authors: X
authors: Hua
authors: Department of Urology, Guizhou Provincial People's Hospital, Guizhou 550002, China.
authors: Dong-bo
authors: DB
authors: Yuan
authors: Department of Urology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China.
authors: Zheng-ming
authors: ZM
authors: Li
authors: Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China.
authors: Wei-de
authors: WD
authors: Zhong
mesh_terms: D000368:Aged; D000483:Alleles; D018450:Disease Progression; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000503:physiopathology; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol