title: [Thrombotic complications of severe forms of varicose disease: modern approach to diagnosis and treatment of hereditary thrombophilia and immunohistochemical peculiarities of vascular wall].
abstract: Experience of treatment of 176 patients, suffering thrombotic complications of severe forms of the lower extremities varicose disease (VDLE), was analyzed. In 20 patients, suffering varicothrombophlebitis (VTHPH) in severe forms of VDLE, morphological and immunohistochemical changes in the venous wall and surrounding tissues were studied. There were examined 28 patients, in whom thrombotic complications of the VDLE have had occurred, using diagnostic complex "PLR genetics thrombophilia". Recurrent course of thrombotic complications and coexistence of VTHPH and thrombosis of deep veins have had constitute the main criterion of such patients selection. The groups of patients, suffering severe forms of VDLE, were delineated, depending on thrombotic process localization, differentiated tactics of their surgical treatment was proposed.
authors: L M
authors: LM
authors: Chernukha
authors: S P
authors: SP
authors: Shchukin
authors: T M
authors: TM
authors: Archakova
mesh_terms: D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000235:genetics / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005268:Femoral Vein / Q000473:pathology / Q000601:surgery; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D039421:Integrin alpha2 / Q000097:blood / Q000235:genetics; D039661:Integrin beta3 / Q000097:blood / Q000235:genetics; D007866:Leg / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics / Q000378:metabolism; D012501:Saphenous Vein / Q000473:pathology / Q000601:surgery; D019851:Thrombophilia / Q000097:blood / Q000473:pathology / Q000601:surgery*; D014648:Varicose Veins / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000601:surgery*
chemical_list: D001779:Blood Coagulation Factors; C061248:ITGB3 protein, human; D039421:Integrin alpha2; D039661:Integrin beta3; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human