title: Association between tea and coffee consumption and risk of laryngeal cancer: a meta-analysis.
abstract: OBJECTIVE
  Epidemiological studies evaluating the association of tea and coffee consumption and the risk of laryngeal cancer have produced inconsistent results. Thus, we conducted a meta-analysis to assess the relationship between tea and coffee consumption and laryngeal cancer risk.
  
  
  METHODS
  Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. The random effect model was used based on heterogeneity test. Publication bias was estimated using Egger's regression asymmetry test. As a result, 11 articles were included in this meta-analysis.
  
  
  RESULTS
  For tea consumption and laryngeal cancer, data from 8 studies including 2167 laryngeal cancer cases were used, and the pooled results suggested that highest tea consumption versus lowest level wasn't associated with the risk of laryngeal cancer [summary RR = 0.909, 95% CI = 0.674-1.227]. Eight studies comprising 2596 laryngeal cancer cases for coffee consumption and laryngeal cancer risk were included, and no association was found (summary RR = 1.218, 95% CI = 0.915-1.622).
  
  
  CONCLUSIONS
  Finding from this meta-analysis suggested that tea and coffee consumption weren't associated with the risk of laryngeal cancer. Since the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are warranted to confirm this result.
authors: Department of Otorhinolaryngology, The Central Hospital of Yiwu City, Affiliated Hospital of Wen Zhou Medical University Yiwu 322000, China.
authors: Zhiguo
authors: Z
authors: Ouyang
authors: Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai 200092, China ; Ear Institute, Shanghai Jiao Tong University, School of Medicine Shanghai 200092, China.
authors: Zhaoyan
authors: Z
authors: Wang
authors: Department of Otorhinolaryngology, The Central Hospital of Yiwu City, Affiliated Hospital of Wen Zhou Medical University Yiwu 322000, China.
authors: Jian
authors: J
authors: Jin
keywords: Tea consumption; coffee consumption; laryngeal cancer; meta-analysis