title: Three-dimensional skin models of psoriasis.
abstract: Three-dimensional models of psoriatic skin occupy an intermediate position between cell cultures and animal-based models. Unlike cultured cells, they closely imitate changes in cell differentiation and metabolism, which are characteristic of psoriatic lesional skin. Because 3-dimensional models exclude nonspecific influences of the surrounding organs and tissues, in some studies they are preferred over animal-based models. Moreover, 3-dimensional models can be used for drug screening and testing new pharmacological approaches. In this paper, we discuss how 3-dimensional models of psoriatic lesional skin were created and developed. We also analyze their prospects in experimental studies of psoriasis.
authors: Federal Non-Profit Research Institution of the Russian Academy of Sciences, N.I. Vavilov Institute of General Genetics, Moscow, Russia.
authors: Anna G
authors: AG
authors: Soboleva
authors: Alexandre
authors: A
authors: Mezentsev
authors: Alena
authors: A
authors: Zolotorenko
authors: Sergey
authors: S
authors: Bruskin
authors: Eleonora
authors: E
authors: Pirusian
mesh_terms: D016207:Cytokines; D006801:Humans; D021621:Imaging, Three-Dimensional; D008962:Models, Theoretical; D011565:Psoriasis / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000473:pathology*
chemical_list: D016207:Cytokines