title: Validation of the Japanese version of HFS-14, a disease-specific quality of life scale for patients suffering from hand-foot syndrome.
abstract: OBJECTIVE
  The purpose of this study was to develop a Japanese version of hand-foot syndrome (HFS)-specific quality of life (QOL) questionnaire (HFS-14) to evaluate and monitor the QOL of patients with a possibility of HFS.
  
  
  METHODS
  The original English version of HFS-14 was translated and slightly modified into Japanese, and the Japanese HFS-14 was administered to 187 patients receiving chemotherapy with high risk of developing HFS as outpatients in four institutions in Japan. Factor validity, internal consistency, correlation with the Skindex-16 and Dermatology Life Quality Index (DLQI) scores, known group validity, and test-retest reliability were analyzed for 105 patients who developed HFS. Next, we compared HFS-14 with DLQI and Skindex-16.
  
  
  RESULTS
  Factor analysis confirmed the factor structure (one putative scale) of the Japanese HFS-14. Cronbach's alpha was over 0.90. The Japanese HFS-14 score was correlated with the Skindex-16 and DLQI score. Intra-class correlation coefficients were over 0.80. Patients with severe HFS reported significantly poorer HFS-14 score than those with mild HFS. The Skindex-16 and DLQI scores were also significantly different in patients with different Common Terminology Criteria for Adverse Events (CTCAE) grades, but with smaller effect sizes than those for the HFS-14 score.
  
  
  CONCLUSIONS
  The Japanese HFS-14 provides a valid and reliable score for monitoring and evaluating HFS.
authors: Department of Adult Nursing/Palliative Care Nursing, Graduate School of Medicine, The University of Tokyo, 7-3-1 Bunkyo-kuHongo, Tokyo, 113-0033, Japan, naokom-tky@umin.ac.jp.
authors: Naoko
authors: N
authors: Mikoshiba
authors: Noriko
authors: N
authors: Yamamoto-Mitani
authors: Kazuki
authors: K
authors: Sato
authors: Yoshinari
authors: Y
authors: Asaoka
authors: Takamasa
authors: T
authors: Ohki
authors: Misato
authors: M
authors: Ohata
authors: Mitsunori
authors: M
authors: Miyashita
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D044466:Asian People; D005163:Factor Analysis, Statistical; D005260:Female; D060831:Hand-Foot Syndrome / Q000523:psychology* / Q000628:therapy; D006801:Humans; D007564:Japan; D007802:Language; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014175:Translating
chemical_list: D000970:Antineoplastic Agents