title: Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery.
abstract: To achieve precise and sensitive detection of chemotherapy-resistant hepatoblastoma pulmonary metastases, we performed surgery using indocyanine green (ICG) fluorescence imaging navigation. Lung metastasectomies were performed in 10 patients aged from 1 to 11 years. ICG (0.5 mg/kg) was injected intravenously 24 h before the operation. After a thoracotomy had been performed, a 760-nm infrared ray was applied to the lung using a generator and the 830-nm evoked fluorescence was collected and visualized on a real-time display. In total, 250 fluorescence-positive lesions were extirpated in 37 operations. All of the pathologically positive lesions were clearly fluorescence positive. The diameter of the smallest detectable lesion was 0.062 mm. In two patients, there were 29 extirpated lesions that were pathologically proven not to be hepatoblastoma metastases. Although a problem of false positive remains, this method is very useful for the detection of small pulmonary metastases.
authors: Department of Surgery, Kanagawa Children's Medical Center, 2-138-4, Mutsukawa, Minami-ku, Yokohama, 232-8555, Japan, norihikok@nifty.com.
authors: Norihiko
authors: N
authors: Kitagawa
authors: Masato
authors: M
authors: Shinkai
authors: Kyoko
authors: K
authors: Mochizuki
authors: Hidehito
authors: H
authors: Usui
authors: Hisayuki
authors: H
authors: Miyagi
authors: Kaori
authors: K
authors: Nakamura
authors: Mio
authors: M
authors: Tanaka
authors: Yukichi
authors: Y
authors: Tanaka
authors: Mitsuo
authors: M
authors: Kusano
authors: Seiji
authors: S
authors: Ohtsubo
mesh_terms: D002648:Child; D002675:Child, Preschool; D004396:Coloring Agents; D003952:Diagnostic Imaging / Q000379:methods*; D018197:Hepatoblastoma / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D006801:Humans; D007208:Indocyanine Green; D007223:Infant; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods*; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted / Q000379:methods*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green