title: Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report.
abstract: Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.
authors: *Departimento di Biotecnologie e Scienze Medico-Chirurgiche, Universita' di Roma "La Sapienza" Latina 04100, Italy †Istituto Chirurgico Ortopedico Traumatologico, Latina 04100, Italy ‡Dipartimento di Medicina Molecolare, Università di Roma "La Sapienza", Roma 00161, Italy.
authors: Luca
authors: L
authors: Pacini
authors: Daniela
authors: D
authors: Bastianelli
authors: Donatella
authors: D
authors: Ponti
authors: Paolo
authors: P
authors: Rosa
authors: Vincenzo
authors: V
authors: Petrozza
authors: Giuseppe
authors: G
authors: Giannini
authors: Giuseppe
authors: G
authors: Ragona
authors: Antonella
authors: A
authors: Calogero
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000483:Alleles; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D054316:Biomarkers, Pharmacological / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics*; D000068818:Cetuximab; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004252:DNA Mutational Analysis; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D000077544:Panitumumab; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D054316:Biomarkers, Pharmacological; D014408:Biomarkers, Tumor; D047428:Protein Kinase Inhibitors; D000077544:Panitumumab; D000068818:Cetuximab