title: Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps.
abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most frequently encountered chronic nasal diseases with a significant impact on patient quality of life. The aim of our study was therefore to investigate the association between the POSTN, IL-4, and IL-13 gene expression and the nasal polyp development. The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls. The expression level was investigated using reverse transcription-polymerase chain reaction assays in the polyp tissue and the mucosa of paranasal sinus collected while undergoing functional endoscopic sinus surgery. Expression of the mRNAs of all three genes, IL-4, IL-13, and POSTN, was significantly greater in the paired tissues of CRS patients with NPs or without NPs than in control subjects, with highest levels of POSTN and IL-13 seen in CRSwNP. An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of chronic rhinosinusitis with nasal polyps, but polyp formation seemed to be associated especially with POSTN and IL-13 expression.
authors: 1 Department of Otolaryngology and Laryngological Oncology, Medical University of Lodz , Lodz, Poland .
authors: Jaroslaw
authors: J
authors: Milonski
authors: Hanna
authors: H
authors: Zielinska-Blizniewska
authors: Ireneusz
authors: I
authors: Majsterek
authors: Karolina
authors: K
authors: Przybyłowska-Sygut
authors: Przemyslaw
authors: P
authors: Sitarek
authors: Barbara
authors: B
authors: Korzycka-Zaborowska
authors: Jurek
authors: J
authors: Olszewski
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012852:Sinusitis / Q000235:genetics* / Q000473:pathology
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C578095:IL13 protein, human; C508598:IL4 protein, human; D018793:Interleukin-13; C512835:POSTN protein, human; D012333:RNA, Messenger; D015847:Interleukin-4