title: Rh(II)-catalyzed cycloadditions of 1-tosyl 1,2,3-triazoles with 2H-azirines: switchable reactivity of Rh-azavinylcarbene as [2C]- or aza-[3C]-synthon.
abstract: The Rh(II)-catalyzed formal [3+2] and [3+3] cycloadditions of 1-tosyl 1,2,3-triazoles with 2H-azirines have been developed, which enable the efficient synthesis of polysubstituted 3-aminopyrroles and 1,2-dihydropyrazines, respectively. The reported [3+2] cycloaddition represents the first application of 1-sulfonyl 1,2,3-triazole as a [2C]-component in relevant cycloaddition reactions.
authors: The Comprehensive AIDS Research Center and The Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, P. R. China. yefengtang@tsinghua.edu.cn.
authors: Yuanhao
authors: Y
authors: Wang
authors: Xiaoqiang
authors: X
authors: Lei
authors: Yefeng
authors: Y
authors: Tang
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D001389:Azirines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D001389:Azirines; D014230:Triazoles; C030011:carbene; D002244:Carbon; D012238:Rhodium; D008697:Methane