title: Nanomedicine strategies for treatment of secondary spinal cord injury.
abstract: Neurological injury, such as spinal cord injury, has a secondary injury associated with it. The secondary injury results from the biological cascade after the primary injury and affects previous uninjured, healthy tissue. Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly. Unfortunately, the delivery of effective therapeutics is quite limited. Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help treat disease by delivering drugs to specific tissues, enhancing detection methods, or a mixture of both. Incorporating nanomedicine into the treatment of neuronal injury and disease would likely push nanomedicine into a new light. This review highlights the various pathological issues involved in secondary spinal cord injury, current treatment options, and the improvements that could be made using a nanomedical approach.
authors: Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, IN, USA ; Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA.
authors: Désirée
authors: D
authors: White-Schenk
authors: Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, IN, USA ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA ; Department of Basic Medical Sciences, Lynn School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors: Riyi
authors: R
authors: Shi
authors: Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, IN, USA ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA ; Department of Basic Medical Sciences, Lynn School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA ; Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA.
authors: James F
authors: JF
authors: Leary
mesh_terms: D006801:Humans; D050997:Nanomedicine; D013119:Spinal Cord Injuries / Q000628:therapy*
keywords: acrolein; drug delivery; methylprednisolone; secondary injury; spinal cord injury