title: Genetic Variants of DICE1/INTS6 in German Prostate Cancer Families with Linkage to 13q14.
abstract: BACKGROUND
  Prostate cancer is the most frequent malignancy found to occur in Caucasian men, but its genetic basis remains elusive. A prostate cancer-susceptibility locus has been identified on chromosome 13q14. The tumour suppressor gene deleted in cancer cells 1 (DICE1/INTS6) is located within this interval on 13q14.3.
  
  
  METHODS
  We performed mutation analysis of the DICE1/INTS6 gene in thirteen German prostate cancer families.
  
  
  CONCLUSIONS
  None of the patients harboured DICE1 mutations, and similar frequencies of the previously identified 13 bp deletion polymorphism in the DICE1 promoter were observed in the familial prostate cancer patients as compared with sporadic prostate cancer patients and controls. However, in one family with three affected brothers, the variations c.1215A>C (p.T405T) in exon 10 and c.2568A>G (p.S856S) in exon 17 were detected in a heterozygous pattern. In sporadic prostate cancer patients, variant c.2568A>G (p.S856S) was detected in 10/325 (3.08%) compared with 5/207 (2.42%) control samples (p > 0.05). We conclude that DICE1 appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer.
authors: Klinik fx00FC;r Urologie, Otto-von-Guericke-Universitx00E4;t, Magdeburg, Germany.
authors: Malte
authors: M
authors: Böhm
authors: Christiane
authors: C
authors: Maier
authors: Rainer
authors: R
authors: Küfer
authors: Albrecht
authors: A
authors: Röpke
authors: Walther
authors: W
authors: Vogel
authors: Ilse
authors: I
authors: Wieland
mesh_terms: D000368:Aged; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D005190:Family; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics; D014644:Genetic Variation; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; C121427:INTS6 protein, human; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D025521:Tumor Suppressor Proteins