title: Behavioural profile of Wistar rats with unilateral striatal lesion by quinolinic acid (animal model of Huntington disease) post-injection of apomorphine and exposure to static magnetic field.
abstract: We analysed the motor behaviour of Wistar rats after 7 days lesion in the left striatum, injected with apomorphine (APO) and stimulated by a continuous magnetic field of 3,200 Gauss. For the behaviour assessment, we utilised the activity cage test and the rotarod test. Sixty-eight male Wistar rats were divided into six groups: control, sham, sham magnetic, lesion, and stimulated South and North Poles. After the experiments, coronal sections of the striatum were taken and stained with Nissl for analysis of the lesion. In the activity cage test for distance (F = 3.19), time of activity (F = 5.46) and crossings (F = 3.31) in all groups, except for the North Pole-stimulated group, we observed a significant increase in these behaviours when compared to the control group. Considering the number of counterclockwise turns, we observed a significant increase in the lesion in the South and North Pole stimulation groups compared with the control group. Highlighting the minor number of counterclockwise turns observed in the North Pole-stimulated group in relation to the South Pole-stimulated and Lesion groups (F = 16.01). The rotarod test revealed a decrease in the time spent in this apparatus for the Lesion group when compared to all other groups (F = 5.46). The morphometric analysis showed a reduction in the number of neurons in the Lesion group in relation to all other groups (F = 5.13). Thus, the results suggest that the static magnetic field north and south promoted a distinct behavioural profile and morphological preservation after 7 days of lesion with quinolinic acid associated with APO.
authors: Laboratory of Neuropsychobiology and Motor Behavior, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, University of São Paulo (USP), Av. dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
authors: Carolina
authors: C
authors: Giorgetto
authors: Elaine Cristina Mazzei
authors: EC
authors: Silva
authors: Takae Tamy
authors: TT
authors: Kitabatake
authors: Guilherme
authors: G
authors: Bertolino
authors: João Eduardo
authors: JE
authors: de Araujo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000473:pathology*; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000494:pharmacology*; D007839:Functional Laterality / Q000502:physiology*; D006816:Huntington Disease / Q000139:chemically induced / Q000473:pathology*; D060526:Magnetic Fields; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009474:Neurons / Q000473:pathology*; D017378:Quinolinic Acid / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013223:Statistics as Topic
chemical_list: D018491:Dopamine Agonists; D017378:Quinolinic Acid; D001058:Apomorphine