title: Clinical and prognostic features of erionite-induced malignant mesothelioma.
abstract: This review analytically examines the published data for erionite-related malignant pleural mesothelioma (E-MPM) and any data to support a genetically predisposed mechanism to erionite fiber carcinogenesis. Adult patients of age ≥18 years with erionite-related pleural diseases and genetically predisposed mechanisms to erionite carcinogenesis were included, while exclusion criteria included asbestos- or tremolite-related pleural diseases. The search was limited to human studies though not limited to a specific timeframe. A total of 33 studies (31042 patients) including 22 retrospective studies, 6 prospective studies, and 5 case reports were reviewed. E-MPM developed in some subjects with high exposures to erionite, though not all. Chest CT was more reliable in detecting various pleural changes in E-MPM than chest X-ray, and pleural effusion was the most common finding in E-MPM cases, by both tests. Bronchoalveolar lavage remains a reliable and relatively less invasive technique. Chemotherapy with cisplatin and mitomycin can be administered either alone or following surgery. Erionite has been the culprit of numerous malignant mesothelioma cases in Europe and even in North America. Erionite has a higher degree of carcinogenicity with possible genetic transmission of erionite susceptibility in an autosomal dominant fashion. Therapeutic management for E-MPM remains very limited, and cure of the disease is extremely rare.
authors: Department of Thoracic Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
authors: Ersin
authors: E
authors: Demirer
authors: Saint Elizabeth Health Center, Youngstown, OH, USA.
authors: Christian F
authors: CF
authors: Ghattas
authors: Division of Pulmonary, Critical Care Medicine and Sleep, University of South Florida, Tampa, FL, USA.
authors: Mohamed O
authors: MO
authors: Radwan
authors: Division of Pulmonary, Critical Care Medicine and Sleep, University of South Florida, Tampa, FL, USA. eelamin@health.usf.edu.
authors: Elamin M
authors: EM
authors: Elamin
mesh_terms: D000328:Adult; D001194:Asbestos / Q000009:adverse effects*; D017636:Asbestos, Amphibole; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010994:Pleura / Q000000981:diagnostic imaging; D010996:Pleural Effusion / Q000000981:diagnostic imaging; D010997:Pleural Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D017641:Zeolites / Q000009:adverse effects*
chemical_list: D017636:Asbestos, Amphibole; C083174:erionite; D017641:Zeolites; D001194:Asbestos; C005846:tremolite
keywords: Asbestos; malignant mesothelioma; pleural effusion