title: Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations.
abstract: OBJECTIVE
  Increased amplitudes in high-frequency brain electrical activity are reported with menopausal hot flashes. We report outcomes associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring--a noninvasive neurotechnology for autocalibration of neural oscillations--by women with perimenopausal and postmenopausal hot flashes.
  
  
  METHODS
  Twelve women with hot flashes (median age, 56 y; range, 46-69 y) underwent a median of 13 (range, 8-23) intervention sessions for a median of 9.5 days (range, 4-32). This intervention uses algorithmic analysis of brain electrical activity and near real-time translation of brain frequencies into variable tones for acoustic stimulation. Hot flash frequency and severity were recorded by daily diary. Primary outcomes included hot flash severity score, sleep, and depressive symptoms. High-frequency amplitudes (23-36 Hz) from bilateral temporal scalp recordings were measured at baseline and during serial sessions. Self-reported symptom inventories for sleep and depressive symptoms were collected.
  
  
  RESULTS
  The median change in hot flash severity score was -0.97 (range, -3.00 to 1.00; P = 0.015). Sleep and depression scores decreased by -8.5 points (range, -20 to -1; P = 0.022) and -5.5 points (range, -32 to 8; P = 0.015), respectively. The median sum of amplitudes for the right and left temporal high-frequency brain electrical activity was 8.44 μV (range, 6.27-16.66) at baseline and decreased by a median of -2.96 μV (range, -11.05 to -0.65; P = 0.0005) by the final session.
  
  
  CONCLUSIONS
  Hot flash frequency and severity, symptoms of insomnia and depression, and temporal high-frequency brain electrical activity decrease after High-resolution, relational, resonance-based, electroencephalic mirroring. Larger controlled trials with longer follow-up are warranted.
authors: From the 1Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC; 2Brain State Technologies LLC, Scottsdale, AZ; and 3Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors: Charles H
authors: CH
authors: Tegeler
authors: Catherine L
authors: CL
authors: Tegeler
authors: Jared F
authors: JF
authors: Cook
authors: Sung W
authors: SW
authors: Lee
authors: Nicholas M
authors: NM
authors: Pajewski
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D058256:Brain Waves / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D019584:Hot Flashes / Q000628:therapy*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology*; D012720:Severity of Illness Index; D016896:Treatment Outcome