title: MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.
abstract: Glioblastoma multiforme (GBM) is known as a highly malignant brain tumor with a poor prognosis, despite intensive research and clinical efforts. In this study, we observed that microRNA-873 (miR-873) was expressed at low levels in GBM and that the overexpression of miR-873 dramatically reduced the cell proliferation, migration, and invasion of GBM cells. Our further investigations of the inhibition mechanism indicated that miR-873 negatively affected the carcinogenesis and metastasis of GBM by down-regulating the expression of IGF2BP1, which stabilizes the mRNA transcripts of its target genes. These results demonstrate that miR-873 may constitute a potential target for GBM therapy.
authors: From the Departments of Clinical Laboratory and.
authors: Ren-jie
authors: RJ
authors: Wang
authors: Neurosurgery, Pingjin Hospital, Logistics College of Armed Police Forces, Tianjin 300162, China.
authors: Jian-wei
authors: JW
authors: Li
authors: From the Departments of Clinical Laboratory and.
authors: Bu-he
authors: BH
authors: Bao
authors: Neurosurgery, Pingjin Hospital, Logistics College of Armed Police Forces, Tianjin 300162, China.
authors: Huan-cheng
authors: HC
authors: Wu
authors: From the Departments of Clinical Laboratory and.
authors: Zhen-hua
authors: ZH
authors: Du
authors: Neurosurgery, Pingjin Hospital, Logistics College of Armed Police Forces, Tianjin 300162, China.
authors: Jing-liang
authors: JL
authors: Su
authors: From the Departments of Clinical Laboratory and.
authors: Ming-hua
authors: MH
authors: Zhang
authors: Neurosurgery, Pingjin Hospital, Logistics College of Armed Police Forces, Tianjin 300162, China lianghaiqian711@163.com.
authors: Hai-qian
authors: HQ
authors: Liang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009362:Neoplasm Metastasis; D016601:RNA-Binding Proteins / Q000235:genetics*; D015854:Up-Regulation
chemical_list: C406144:IGF2BP1 protein, human; C000598459:MIRN873 microRNA, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins
keywords: GBM; Gene Expression; Glioblastoma; IGF2BP1; Insulin-like Growth Factor (IGF); MicroRNA (miRNA); MicroRNA Mechanism; MicroRNA miR-873