title: Structure based approaches for targeting non-coding RNAs with small molecules.
abstract: The increasing appreciation of the central role of non-coding RNAs (miRNAs and long non-coding RNAs) in chronic and degenerative human disease makes them attractive therapeutic targets. This would not be unprecedented: the bacterial ribosomal RNA is a mainstay for antibacterial treatment, while the conservation and functional importance of viral RNA regulatory elements has long suggested they would constitute attractive targets for new antivirals. Oligonucleotide-based chemistry has obvious appeals but also considerable pharmacological limitations that are yet to be addressed satisfactorily. Recent studies identifying small molecules targeting non-coding RNAs may provide an alternative approach to oligonucleotide methods. Here we review recent work investigating new structural and chemical principles for targeting RNA with small molecules.
authors: Department of Chemistry, University of Washington, Seattle, Box 351700, Seattle 98195, USA.
authors: Matthew D
authors: MD
authors: Shortridge
authors: Department of Chemistry, University of Washington, Seattle, Box 351700, Seattle 98195, USA. Electronic address: varani@chem.washington.edu.
authors: Gabriele
authors: G
authors: Varani
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D053898:Biosynthetic Pathways / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods*; D035683:MicroRNAs / Q000096:biosynthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D022661:RNA, Untranslated / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D035683:MicroRNAs; D022661:RNA, Untranslated; D054852:Small Molecule Libraries