title: Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases.
abstract: Oxidation of cholesterol into oxysterols is a major way of elimination of cholesterol from the liver and extrahepatic tissues, including the brain and the retina. Oxysterols are involved in various cellular processes. Numerous links have been established between oxysterols and several disorders such as neurodegenerative pathologies, retinopathies and atherosclerosis. Different components of the lipid layer such as sphingolipids, sterols and proteins participate to membrane fluidity and forme lipid rafts microdomains. Few data are available on the links between lipids rafts and oxysterols. The purpose of this review is to suggest the potential role of lipid rafts microdomains in the development of retinopathies with special emphasis and opening perspectives of their interactions with oxysterols. Actually cholesterol oxidation mechanism may have deleterious effect on its ability to support rafts formation .This review suggest that the effect of oxysterols of lipid rafts would probably depend on the oxysterol molecule and cell type.
authors: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Equipe Œil, Nutrition et Signalisation Cellulaire, F-21000 Dijon, France; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; Université de Bourgogne, Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.
authors: Rodolphe
authors: R
authors: Filomenko
authors: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Equipe Œil, Nutrition et Signalisation Cellulaire, F-21000 Dijon, France; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; Université de Bourgogne, Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.
authors: Cynthia
authors: C
authors: Fourgeux
authors: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Equipe Œil, Nutrition et Signalisation Cellulaire, F-21000 Dijon, France; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; Université de Bourgogne, Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France. Electronic address: lionel.bretillon@dijon.inra.fr.
authors: Lionel
authors: L
authors: Bretillon
authors: INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Equipe Œil, Nutrition et Signalisation Cellulaire, F-21000 Dijon, France; CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; Université de Bourgogne, Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; CHU Dijon, Service de Biochimie Clinique, F-21000 Dijon, France.
authors: Ségolène
authors: S
authors: Gambert-Nicot
mesh_terms: D000818:Animals; D005128:Eye Diseases / Q000378:metabolism*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008954:Models, Biological; D013261:Sterols / Q000737:chemistry / Q000378:metabolism*
chemical_list: D013261:Sterols
keywords: CYP46A1; Cholesterol; Lipid rafts; Oxysterols; Retinopathy