title: Activatable nanoprobes for biomolecular detection.
abstract: Precise detection of pathologically relevant biomolecules could provide essential information on important intercellular, cellular, and subcellular events for accurate disease diagnosis and staging, thus leading to appropriate treatment recommendation. Activatable nanoprobes are nanoscale objects that can be turned on through specific reactions or interactions with biomolecules of interest, and afford some advantageous properties for improved detection of biomolecules both in vitro and in vivo. In this brief review, we highlight several recent examples in the development of activatable nanoprobes for biomolecule detection.
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States.
authors: Pengcheng
authors: P
authors: Zhang
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States.
authors: Andrew G
authors: AG
authors: Cheetham
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States.
authors: Lye Lin
authors: LL
authors: Lock
authors: State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
authors: Yaping
authors: Y
authors: Li
authors: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States. Electronic address: hcui6@jhu.edu.
authors: Honggang
authors: H
authors: Cui
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D007287:Inorganic Chemicals / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D007287:Inorganic Chemicals