title: [Anti-NR1 antibodies in anti-N-methyl-D-aspartate receptor encephalitis and schizophrenia].
abstract: The recent discovery of anti-NMDA receptor antibodies and proof of their pathogenic effects in limbic encephalitides raised many questions among neuroscientist and physicians working in the field of schizophrenia. Indeed, this two conditions share several major clinical, pathophysiological or etiological aspects and some authors tend to consider some forms of schizophrenia as mild-encephalitis cases. Some studies have reported the presence of these antibodies in schizophrenic patient's sera without neurological symptoms. These findings suggest new therapeutic perspectives in some schizophrenic patients, despite a low seroprevalence and pathogenic effects that remain to be demonstrated.
authors: Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP-HP, université Paris-Est, DHU PePSY, hôpital Albert Chenevier, 40, rue de Mesly, 94000 Créteil, France - Inserm U955, équipe 15, psychiatrie génétique, Créteil, France - fondation FondaMental, Créteil, France.
authors: Emmanuel
authors: E
authors: Le Guen
authors: Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP-HP, université Paris-Est, DHU PePSY, hôpital Albert Chenevier, 40, rue de Mesly, 94000 Créteil, France - Inserm U955, équipe 15, psychiatrie génétique, Créteil, France - fondation FondaMental, Créteil, France.
authors: Raphaël
authors: R
authors: Doukhan
authors: Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP-HP, université Paris-Est, DHU PePSY, hôpital Albert Chenevier, 40, rue de Mesly, 94000 Créteil, France - Inserm U955, équipe 15, psychiatrie génétique, Créteil, France - fondation FondaMental, Créteil, France.
authors: Nora
authors: N
authors: Hamdani
authors: laboratoire Jean Dausset d'immunologie et d'histocompatibilité, hôpital Saint Louis, Paris, France - LabEx Transplantex, Inserm UMRS 1160, Paris, France - université Paris Diderot, Paris, France.
authors: Ryad
authors: R
authors: Tamouza
authors: institut interdisciplinaire de neuroscience, CNRS UMR 5297, université de Bordeaux, Bordeaux, France.
authors: Laurent
authors: L
authors: Groc
authors: centre de référence maladies rares « syndromes neurologiques paranéoplasiques », Hospices civils de Lyon, hôpital neurologique, Bron, France - Inserm U1028/CNRS UMR 5292, centre de recherché en neurosciences de Lyon, Bron, France - université de Lyon, université Claude-Bernard Lyon-1, Lyon, France.
authors: Jérôme
authors: J
authors: Honnorat
authors: Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP-HP, université Paris-Est, DHU PePSY, hôpital Albert Chenevier, 40, rue de Mesly, 94000 Créteil, France - Inserm U955, équipe 15, psychiatrie génétique, Créteil, France - fondation FondaMental, Créteil, France.
authors: Marion
authors: M
authors: Leboyer
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D012559:Schizophrenia / Q000097:blood* / Q000453:epidemiology / Q000276:immunology
chemical_list: D001323:Autoantibodies; C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate