title: Genetics in myeloma: genetic technologies and their application to screening approaches in myeloma.
abstract: BACKGROUND
  Despite advances in the treatment of multiple myeloma (MM), it remains an incurable malignant disease. Myeloma genetics is intrinsically complex, but it offers an opportunity to categorize the disease and apply a personalized medicine approach.
  
  
  RESULTS
  Research into the genetics of myeloma is moving at a fast pace and is highlighting areas and patient cohorts likely to benefit from specific treatment. Targeting residual disease is likely to be crucial to improved clinical outcome.
  
  
  RESULTS
  Patients in clinical trials are more likely to receive genetic diagnosis than non-trial patients, for whom access is ad hoc and dependent upon regional commissioning arrangements.
  
  
  CONCLUSIONS
  Relating genetics to potential treatment pathways will become crucial for improved myeloma outcomes. Universal access to standardized genetic testing will facilitate modern personalized treatments.
authors: Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield S10 2TH, UK polly.talley@sch.nhs.uk.
authors: Polly J
authors: PJ
authors: Talley
authors: Sheffield Myeloma Research Team (SMaRT), Department of Oncology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK.
authors: Andrew D
authors: AD
authors: Chantry
authors: Sheffield Myeloma Research Team (SMaRT), Department of Oncology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK.
authors: Clive H
authors: CH
authors: Buckle
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005820:Genetic Testing / Q000379:methods / Q000639:trends; D006801:Humans; D056747:Immunomodulation / Q000235:genetics*; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011379:Prognosis; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: diagnosis; genetic technologies; myeloma; personalized medicine