title: Factors associated with participation in a prevention trial aimed at reducing biomarkers of breast cancer risk.
abstract: OBJECTIVE
  Poor enrollment into prevention trials is a major obstacle to the conduct of clinical investigations. This study focuses on cognitive and affective influences on the decision to participate in a clinical trial aimed at reducing biomarkers of breast cancer risk.
  
  
  METHODS
  Following a decision to participate or not in a clinical trial focused on reduction of breast cancer risk, women were recruited into the present study. Data were gathered via telephone survey.
  
  
  RESULTS
  One hundred healthy women took part in the current study, 72 of whom had participated in the clinical trial, and 28 of whom had declined participation. Women who decided to enroll perceived more benefits and fewer costs, and they experienced more positive emotions and fewer negative emotions. They also made the decision more quickly, more easily, were more satisfied with it, and had fewer regrets than women who declined participation in the clinical trial.
  
  
  CONCLUSIONS
  Participants to this clinical trial differed from nonparticipants in terms of antecedents, process, and outcomes of the decision to enroll.
  
  
  CONCLUSIONS
  Although obstacles exist, accrual might be improved by greater emphasis on the practical and psychosocial benefits to participants.
authors: Department of Communication Arts & Sciences, The Pennsylvania State University, University Park, USA. Electronic address: JPD16@PSU.EDU.
authors: James Price
authors: JP
authors: Dillard
authors: Department of Education Psychology, Counseling, and Special Education, The Pennsylvania State University, University Park, USA.
authors: Bonnie J F
authors: BJ
authors: Meyer
authors: Department of Communication Arts & Sciences, The Pennsylvania State University, University Park, USA.
authors: Denise H
authors: DH
authors: Solomon
authors: Division of Endocrinology, Diabetes, and Metabolism, The Pennsylvania State University, Hershey Medical Center, Hershey, USA.
authors: Andrea
authors: A
authors: Manni
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic / Q000523:psychology*; D003657:Decision Making; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D009369:Neoplasms / Q000188:drug therapy / Q000523:psychology*; D010358:Patient Participation / Q000523:psychology*; D017060:Patient Satisfaction; D018579:Patient Selection; D035842:Research Subjects / Q000523:psychology*; D011795:Surveys and Questionnaires
keywords: Accrual; Decision making; Emotion; Enrollment; Recruitment; Satisfaction