title: Life-threatening anaphylactic shock due to chlorhexidine on the central venous catheter: a case series.
abstract: In this article, we report two life-threatening anaphylactic shocks by an antiseptic coated central venous catheter (CVC) within a 6-month period in our cancer center. Anaphylactic shock was preceded immediately after insertion of a central venous catheter (CVC) coated with silver sulphadiazine and chlorhexidine acetate (Blue FlexTip(®) ARROWg(+)ard Blue(®), 14Ga, Arrow International, Inc. USA). Though antiseptic coated CVC anaphylaxis has been reported in Japan, Europe and America, to our knowledge, this is first reported in China. We present these rare cases to remind clinicians about hypersensitivity to chlorhexidine that could potentially be life-threatening.
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center No. 270 Dong'an Road, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University No. 270 Dong'an Road, Shanghai 200032, China.
authors: Meilin
authors: M
authors: Weng
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center No. 270 Dong'an Road, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University No. 270 Dong'an Road, Shanghai 200032, China.
authors: Minmin
authors: M
authors: Zhu
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center No. 270 Dong'an Road, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University No. 270 Dong'an Road, Shanghai 200032, China.
authors: Wankun
authors: W
authors: Chen
authors: Department of Anaesthesiology, Fudan University Shanghai Cancer Center No. 270 Dong'an Road, Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University No. 270 Dong'an Road, Shanghai 200032, China.
authors: Changhong
authors: C
authors: Miao
keywords: Chlorhexidine; anaphylactic shock; central venous catheter