title: Short-term precision assessment of trabecular bone score and bone mineral density using dual-energy X-ray absorptiometry with different scan modes: an in vivo study.
abstract: OBJECTIVE
  We estimated the in vivo reproducibility of trabecular bone score (TBS) from dual-energy X-ray absorptiometry (DXA) using different imaging modes to be compared to that of bone mineral density (BMD).
  
  
  METHODS
  We enrolled 30 patients for each imaging mode: fast-array, array, high definition. Each patient underwent two DXA examinations with in-between repositioning. BMD and TBS were obtained according to the International Society for Clinical Densitometry guidelines. The coefficient of variation (CoV) was calculated as the ratio between root mean square standard deviation and mean, percent least significant change (LSC) as 2.77 × CoV, reproducibility as the complement to 100% LSC.
  
  
  RESULTS
  Fast-array imaging mode resulted in 0.8% CoV and 2.1% LSC for BMD, 1.9% and 5.3% for TBS, respectively; array imaging mode resulted in 0.7% and 2.0% for BMD, 1.9% and 5.2%, for TBS; high-definition imaging mode resulted in 0.7% and 2.0%, for BMD; 2.0% and 5.4% for TBS, respectively. Reproducibility of TBS (95%) was significantly lower than that of BMD (98%) (p < 0.012). Difference in reproducibility among the imaging modes was not significant for either BMD or TBS (p = 0.942).
  
  
  CONCLUSIONS
  While TBS reproducibility was significantly lower than that of BMD, differences among imaging modes were not significant for both TBS and BMD.
  
  
  CONCLUSIONS
  • TBS is an emerging tool for assessing BMD. • TBS reproducibility is lower than that of BMD. • Differences between imaging modes are not significant for either TBS or BMD.
authors: Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, via Festa del Perdono 7, 20122, Milano, Italy, michele.bandirali@hotmail.it.
authors: Michele
authors: M
authors: Bandirali
authors: Alessandro
authors: A
authors: Poloni
authors: Luca Maria
authors: LM
authors: Sconfienza
authors: Carmelo
authors: C
authors: Messina
authors: Giacomo Davide Edoardo
authors: GD
authors: Papini
authors: Marcello
authors: M
authors: Petrini
authors: Fabio Massimo
authors: FM
authors: Ulivieri
authors: Giovanni
authors: G
authors: Di Leo
authors: Francesco
authors: F
authors: Sardanelli
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D056888:Patient Positioning; D010808:Physical Examination / Q000379:methods; D011446:Prospective Studies; D015203:Reproducibility of Results