title: Hepatitis E virus infection presenting with paraesthesia.
abstract: Hepatitis E virus infection is an emerging disease in developed countries. Acute and chronic infection has been reported, with chronic infection being increasingly reported in immunocompromised patients. Neurological disorders are an emerging manifestation of both acute and chronic hepatitis E virus infection. We report a 77-year-old female presented with paraesthesia and was found to have abnormal liver function tests. Serology was found to be positive for hepatitis E virus IgM, IgG and RNA. Liver function tests normalised after three weeks and her neurological symptoms completely resolved. To our knowledge, this is the first case in Scotland of hepatitis E virus presenting only with neurological symptoms.
authors: Pre-registered Clinical Scientist, West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK Susan.bennett@ggc.scot.nhs.uk.
authors: Susan
authors: S
authors: Bennett
authors: SPR in Virology, West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK.
authors: Kathy
authors: K
authors: Li
authors: Consultant Clinical Scientist, West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK.
authors: Rory N
authors: RN
authors: Gunson
mesh_terms: D000368:Aged; D005260:Female; D016751:Hepatitis E / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008111:Liver Function Tests; D018908:Muscle Weakness / Q000821:virology*; D010292:Paresthesia / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D012606:Scotland; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral
keywords: Hepatitis E virus; neurological; paraesthesia