title: Glutathione-capped CdTe nanocrystals as probe for the determination of fenbendazole.
abstract: Water-soluble glutathione (GSH)-capped CdTe quantum dots (QDs) were synthesized. In pH 7.1 PBS buffer solution, the interaction between GSH-capped CdTe QDs and fenbendazole (FBZ) was investigated by spectroscopic methods, including fluorescence spectroscopy, ultraviolet-visible absorption spectroscopy, and resonance Rayleigh scattering (RRS) spectroscopy. In GSH-capped CdTe QDs solution, the addition of FBZ results in the fluorescence quenching and RRS enhancement of GSH-capped CdTe QDs. And the quenching intensity (enhanced RRS intensity) was proportional to the concentration of FBZ in a certain range. Investigation of the interaction mechanism, proved that the fluorescence quenching and RRS enhancement of GSH-capped CdTe QDs by FBZ is the result of electrostatic attraction. Based on the quenching of fluorescence (enhancement of RRS) of GSH-capped CdTe QDs by FBZ, a novel, simple, rapid and specific method for FBZ determination was proposed. The detection limit for FBZ was 42 ng mL(-1) (3.4 ng mL(-1)) and the quantitative determination range was 0-2.8 μg mL(-1) with a correlation of 0.9985 (0.9979). The method has been applied to detect FBZ in real simples and with satisfactory results.
authors: Chongqing Medical and Health School, Fuling, Chongqing 408100, PR China. Electronic address: 13896550381@126.com.
authors: Qin
authors: Q
authors: Li
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors: Xuanping
authors: X
authors: Tan
authors: Chongqing Medical and Health School, Fuling, Chongqing 408100, PR China.
authors: Jin
authors: J
authors: Li
authors: Chongqing Medical and Health School, Fuling, Chongqing 408100, PR China.
authors: Li
authors: L
authors: Pan
authors: Chongqing Medical and Health School, Fuling, Chongqing 408100, PR China.
authors: Xiaorong
authors: X
authors: Liu
mesh_terms: D000143:Acids / Q000737:chemistry; D019187:Cadmium Compounds / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005273:Fenbendazole / Q000032:analysis* / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry*; D007700:Kinetics; D008027:Light; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D045663:Quantum Dots; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013691:Tellurium / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000143:Acids; D019187:Cadmium Compounds; D000431:Ethanol; D005273:Fenbendazole; D005978:Glutathione; D013691:Tellurium; C028337:cadmium telluride
keywords: Absorption; FBZ; Fluorescence; GSH-capped CdTe QDs; RRS