title: Regulation of translation factor EEF1D gene function by alternative splicing.
abstract: Alternative splicing is an exquisite mechanism that allows one coding gene to have multiple functions. The alternative splicing machinery is necessary for proper development, differentiation and stress responses in a variety of organisms, and disruption of this machinery is often implicated in human diseases. Previously, we discovered a long form of eukaryotic elongation factor 1Bδ (eEF1Bδ; this long-form eEF1Bδ results from alternative splicing of EEF1D transcripts and regulates the cellular stress response by transcriptional activation, not translational enhancement, of heat-shock responsive genes. In this review, we discuss the molecular function of EEF1D alternative splicing products and the estimated implication of human diseases.
authors: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan. kaitsuka@kumamoto-u.ac.jp.
authors: Taku
authors: T
authors: Kaitsuka
authors: Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan. masayuki@med.u-ryukyu.ac.jp.
authors: Masayuki
authors: M
authors: Matsushita
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000378:metabolism; D018869:Heat-Shock Response; D006801:Humans; D020648:Peptide Elongation Factor 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D006360:Heat-Shock Proteins; D020648:Peptide Elongation Factor 1