title: HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between hypoxia-inducible factor-1α (HIF-1α) polymorphisms (-1772C>T and -1790G>A) and the risk of digestive tract cancer.
  
  
  METHODS
  A total of 13 eligible studies were retrieved from PubMed, EMBASE, and the China National Knowledge Infrastructure database. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.
  
  
  RESULTS
  By pooling the eligible studies, we found that the HIF-1α -1772C>T polymorphism was not associated with the risk of developing digestive tract cancer (dominant comparison, OR: 1.156; 95%CI: 0.839-1.593; P heterogeneity = 0.007), and no significant association was found in the Asian population or the Caucasian population. However, for the -1790G>A polymorphism, carriers of the variant -1790A allele had a significantly increased risk of digestive tract cancer compared with those with the wildtype -1790G allele (dominant comparison, OR: 3.252; 95%CI: 1.661-6.368; P heterogeneity < 0.001). Additionally, this increased risk of digestive cancer was only detected in Asians; there was no significant association in Caucasians.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the HIF-1α -1790G>A polymorphism is associated with a significantly increased risk of digestive tract cancer, while the -1772C>T polymorphism is not.
authors: Xiao Sun, Wei Gao, Shao-Hua Shen, Meng Li, Department of Gastroenterology of PLA General Hospital, Beijing 100853, China.
authors: Xiao
authors: X
authors: Sun
authors: Xiao Sun, Wei Gao, Shao-Hua Shen, Meng Li, Department of Gastroenterology of PLA General Hospital, Beijing 100853, China.
authors: Ying-Di
authors: YD
authors: Liu
authors: Xiao Sun, Wei Gao, Shao-Hua Shen, Meng Li, Department of Gastroenterology of PLA General Hospital, Beijing 100853, China.
authors: Wei
authors: W
authors: Gao
authors: Xiao Sun, Wei Gao, Shao-Hua Shen, Meng Li, Department of Gastroenterology of PLA General Hospital, Beijing 100853, China.
authors: Shao-Hua
authors: SH
authors: Shen
authors: Xiao Sun, Wei Gao, Shao-Hua Shen, Meng Li, Department of Gastroenterology of PLA General Hospital, Beijing 100853, China.
authors: Meng
authors: M
authors: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D004067:Digestive System Neoplasms / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: Cancer risk; Digestive tract cancer; Hypoxia-inducible factor-1α; Meta-analysis; Polymorphisms