title: Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.
abstract: Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.
authors: †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
authors: Matthew J
authors: MJ
authors: Bertin
authors: §Environmental Systems Program, University of California-San Diego, La Jolla, California 92093, United States.
authors: Sarah L
authors: SL
authors: Schwartz
authors: †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
authors: John
authors: J
authors: Lee
authors: ∥Department of Statistical Modeling, St. Petersburg State University, St. Petersburg, Russia.|∇Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia.|□The Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia.
authors: Anton
authors: A
authors: Korobeynikov
authors: #Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California 92093, United States.
authors: Pieter C
authors: PC
authors: Dorrestein
authors: †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
authors: Lena
authors: L
authors: Gerwick
authors: †Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.|#Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California 92093, United States.
authors: William H
authors: WH
authors: Gerwick
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D017691:Caribbean Region; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology*; D014733:Vibrio / Q000737:chemistry*
chemical_list: C017493:N(6)-methoxyadenosine; D000241:Adenosine