title: A proposed novel stem cell therapy protocol for liver cirrhosis.
abstract: Currently, there is not an effective therapy for cirrhosis of the liver except for liver transplant. However, finding a compatible liver is difficult due to the low supply and increased demand for healthy livers. Stem cell therapy may be a solution for liver cirrhosis. In our previous report, stem cells from Wharton's jelly and bone marrow were shown to improve liver function in a chemically induced liver fibrosis animal model. However, the immunological rejection of an allograft is always a risk for clinical application. In this study proposal, we suggest using human adipose-derived stem cells (ADSCs) because they are an immune-privileged cell type; they lack human leukocyte antigen-DR expression, and they also suppress the proliferation of activated allogenic lymphocytes and inhibit the production of inflammatory cytokines. In addition, ADSCs contain a sufficient amount of adult stem cells for autologous transplantation. Based on these benefits, ADSCs are promising candidates for clinical application when compared to other stem cell types. The aim of our study will be to investigate the safety and efficacy of autologous ADSCs for the clinical treatment of liver cirrhosis.
authors: Department of Stem Cell Applied Technology, Gwo Xi Stem Cell Applied Technology, Hsinchu, Taiwan.
authors: Po-Cheng
authors: PC
authors: Lin
authors: Tzyy-Wen
authors: TW
authors: Chiou
authors: Zung-Sheng
authors: ZS
authors: Lin
authors: Ko-Chang
authors: KC
authors: Huang
authors: Yi-Chun
authors: YC
authors: Lin
authors: Pi-Chun
authors: PC
authors: Huang
authors: Wan-Sin
authors: WS
authors: Syu
authors: Horng-Jyh
authors: HJ
authors: Harn
authors: Shinn-Zong
authors: SZ
authors: Lin
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*