title: Stereochemical effect on biological activities of new series of piperidin-4-one derivatives.
abstract: New series of (2S,3R,4S,6R)-3-methyl-4-alkyl-2,6-diarylpiperidin-4-ol were synthesised by the reduction of cis-3-alkyl-2,6-diarylpiperidin-4-one using Grignard reagent. The structural assignments and conformational studies of the synthesised compounds were established based on the IR, (1)H NMR, (13)C NMR, NOESY and mass spectral studies. Their stereochemical effect on antibacterial, antifungal and anthelmintic activities was studied.
authors: a Department of Chemistry , Mahendra Institute of Technology , Namakkal 637 503 , India.
authors: Periyasamy
authors: P
authors: Venkatesan
authors: b Department of Chemistry , Sona College of Technology , Salem 636 005 , India.
authors: Thiyagarajan
authors: T
authors: Maruthavanan
mesh_terms: D000871:Anthelmintics / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010880:Piperidines
keywords: Grignard reagent; biological activity; mannich reaction; piperidin-4-one; stereochemical effect