title: Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.
abstract: Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases.
authors: Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden. davide.gnocchi@ki.se.
authors: Davide
authors: D
authors: Gnocchi
authors: Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden. Eva.Hurt-Camejo@astrazeneca.com.|Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden. Eva.Hurt-Camejo@astrazeneca.com.
authors: Matteo
authors: M
authors: Pedrelli
authors: Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden. Eva.Hurt-Camejo@astrazeneca.com.
authors: Eva
authors: E
authors: Hurt-Camejo
authors: Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden. paolo.parini@ki.se.
authors: Paolo
authors: P
authors: Parini