title: Fecal microbiota transplantation for the management of Clostridium difficile infection.
abstract: This article discusses the use of fecal microbiota transplantation (FMT) for the treatment of recurrent Clostridium difficile infection (CDI). The disruption of the normal gut microbiota is central to the pathogenesis of CDI, and disruption persists in recurrent disease. The use of FMT for recurrent CDI is characterized by a high response rate and short term safety is excellent, although the long-term effects of FMT are as yet unknown.
authors: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Division of Infectious Diseases, Department of Internal Medicine, Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA.
authors: Krishna
authors: K
authors: Rao
authors: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan School of Medicine, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: youngvi@umich.edu.
authors: Vincent B
authors: VB
authors: Young
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000382:microbiology / Q000628:therapy*; D019468:Disease Management; D005243:Feces / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology* / Q000628:therapy; D064307:Microbiota
keywords: Clostridium difficile; Colitis; Fecal microbiota transplantation; Microbiome; Nonantibiotic treatment; Recurrent C difficile infection