title: Retrospective Clinical Trial of Fusidic Acid versus Petrolatum in the Postprocedure Care of Clean Dermatologic Procedures.
abstract: BACKGROUND
  Clean dermatologic procedures create wounds with a low risk of infection (usually up to 5%). Whether the use of topical antibiotics is advocated, with regard to its efficacy and safety issues such as antibiotic resistance and sensitizing potential, is controversial. Fusidic acid, a topical antibiotic against gram-positive bacteria, is a rare sensitizer and commonly used in postprocedure care in Korea.
  
  
  OBJECTIVE
  This is a retrospective study aimed at comparing the efficacy and safety between fusidic acid and petrolatum for the postprocedure care of clean dermatologic procedures.
  
  
  METHODS
  Patients were treated with either fusidic acid or petrolatum ointment, applied on the wound created during clean dermatologic procedures such as biopsy of the punch, incisional, excisional, and shave types. The efficacy, adverse events, and subjective level of satisfaction were retrieved from medical records.
  
  
  RESULTS
  A total of 414 patients with a total of 429 wounds were enrolled. The overall rate of adverse events was 0.9%, and the rates of adverse events in the fusidic acid group and the petrolatum group were 1.4% and 0.5%, respectively (p=0.370). There was no wound discharge, pain, tenderness, swelling, induration, or dehiscence in both groups. The patients' self-assessment of the wound was not significantly different between the two treatment groups.
  
  
  CONCLUSIONS
  Our findings support the hypothesis that the routine prophylactic use of topical antibiotics is not indicated for clean dermatologic procedures. We recommend the use of petrolatum in the postoperative care of clean dermatologic procedures because of its equivalent efficacy and superior safety profiles.
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea.
authors: Dong Hun
authors: DH
authors: Lee
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors: Dong Young
authors: DY
authors: Kim
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors: So Young
authors: SY
authors: Yoon
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea. ; Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors: Hyun Sun
authors: HS
authors: Park
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea. ; Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors: Hyun-Sun
authors: HS
authors: Yoon
authors: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea. ; Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
authors: Soyun
authors: S
authors: Cho
keywords: Dermatologic surgical procedures; Fusidic acid; Infection; Petrolatum; Wound healing