title: Analysis of choroidal folds in acute Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography.
abstract: OBJECTIVE
  To characterize patients with Vogt-Koyanagi-Harada (VKH) disease with choroidal folds (CFs) and determine how the foveal choroidal thickness changes after initial treatment using high-penetration optical coherence tomography (HP-OCT).
  
  
  METHODS
  In this retrospective observational study, we analyzed 42 eyes of 21 patients with new-onset VKH disease to determine the demographic and clinical differences between patients with and without CFs.
  
  
  RESULTS
  Twenty-four eyes (57.1 %) of 13 patients with VKH disease had CFs. The mean age (p = 0.0009) of patients with CFs was significantly higher than that of those without CFs (49.1 vs 39.4 years respectively). The frequency of disc swelling (p = 0.0001) was significantly higher in eyes with CFs than in those without CFs (95.8 % vs 38.9 %). The choroidal thickness at the first visit (p = 0.0011) was significantly greater in eyes with CFs than in those without CFs (794 ± 144 μm vs 649 ± 113 μm). The choroid 6 months after the initial treatment (p = 0.0118) was significantly thinner in eyes with CFs than in those without CFs (270 ± 92 μm vs 340 ± 80 μm). The frequency of sunset glow fundus at 6 months (p = 0.0334) in eyes with CFs was significantly higher than in those without CFs (62.5 % vs 27.8 %).
  
  
  CONCLUSIONS
  The development of CFs in patients with VKH disease was significantly correlated with age, disc swelling, and choroidal thickness. The eyes with CFs frequently developed a sunset glow fundus. The findings suggested that patients with CFs might have severe and longstanding inflammation of the choroidal tissues.
authors: Department of Ophthalmology E7, Osaka University Medical School, 2-2 Yamada-oka Suita, 565-0871, Osaka, Japan.
authors: Kotaro
authors: K
authors: Tsuboi
authors: Kei
authors: K
authors: Nakai
authors: Chiharu
authors: C
authors: Iwahashi
authors: Fumi
authors: F
authors: Gomi
authors: Yasushi
authors: Y
authors: Ikuno
authors: Kohji
authors: K
authors: Nishida
mesh_terms: D000208:Acute Disease; D000328:Adult; D015862:Choroid Diseases / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000175:diagnosis*; D014792:Visual Acuity / Q000502:physiology