title: Sirolimus-induced interstitial lung disease following pediatric stem cell transplantation.
abstract: Sirolimus-induced ILD is a known but rare complication in adults who have undergone SOT. However, little is known about this adverse effect in children. Diagnosis of sirolimus-induced ILD can be challenging, especially in patients who have difficulty participating in lung function testing. We present a case of presumed sirolimus-induced ILD in a pediatric stem cell transplant patient who developed polycythemia and hypoxemia. To our knowledge, no other cases of sirolimus-induced pulmonary toxicity in children after HCT have been reported.
authors: Division of Pediatric Respiratory Medicine, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
authors: Andrea S
authors: AS
authors: Garrod
authors: Rakesh K
authors: RK
authors: Goyal
authors: Daniel J
authors: DJ
authors: Weiner
mesh_terms: D002648:Child; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D011086:Polycythemia / Q000209:etiology; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D020123:Sirolimus / Q000009:adverse effects*; D033581:Stem Cell Transplantation / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus
keywords: hematopoietic stem cell transplantation; interstitial lung disease; lung function tests; pediatrics; sirolimus