title: [Treatment-resistant depression: state of the art Part II. Treatment].
abstract: OBJECTIVE
  This work would give an overall and up-to-date vision of psychopharmacological and physical strategies of treatment for resistant depression.
  
  
  METHODS
  A PubMed search was done using the keywords "resistant depression treatment", "electroconvulsive therapy", "antidepressants", and the inclusion criteria of adult samples, English, French or Italian languages.
  
  
  RESULTS
  Lots of psycho-pharmacological and physical treatment strategies for resistant depression exist; anyway there is no consensus about their indications and efficacy, which appears still unsatisfactory.
  
  
  CONCLUSIONS
  Further research should move towards the identification of specific clinical picture of treatment resistant depression to develop more efficacious and selective treatment protocols.
authors: Federica
authors: F
authors: Luchini
authors: Luca
authors: L
authors: Cosentino
authors: Laura
authors: L
authors: Pensabene
authors: Mauro
authors: M
authors: Mauri
authors: Lorenzo
authors: L
authors: Lattanzi
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods; D006801:Humans; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents