title: STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
abstract: Serine/threonine kinase 33 (STK33) is a novel protein that has attracted considerable interest in recent years. Previous research has revealed that STK33 expression plays a special role in cancer cell proliferation. However, the mechanisms of STK33 induction of cancer cells remain largely unknown. In this study, it is demonstrated that STK33 expression varies in NL9980 and L9981 cells which are homogeneous cell lines with similar genetic backgrounds. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 cells. In addition, this protein also promotes epithelial-mesenchymal transition (EMT). Moreover, STK33 knockdown decreases tumor-related gene expression and inhibits cell migration, invasion, and EMT, suggesting that STK33 may be a mediator of signaling pathways that are involved in cancer. In conclusion, our results suggest that STK33 may be an important prognostic marker and a therapeutic target for the metastatic progression of human lung cancer.
authors: Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China.
authors: Ping
authors: P
authors: Wang
authors: Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China.
authors: Hongzhong
authors: H
authors: Cheng
authors: Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China.
authors: Jianqiang
authors: J
authors: Wu
authors: Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China.
authors: Anrun
authors: A
authors: Yan
authors: Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China zhanglbbio@126.com.
authors: Libin
authors: L
authors: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D016203:CDC2 Protein Kinase; D018287:Carcinoma, Large Cell / Q000201:enzymology* / Q000235:genetics / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D018844:Cyclin-Dependent Kinases / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D016158:Genes, p53; D006801:Humans; D016023:Integrins / Q000235:genetics; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000235:genetics; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; C527276:CXCR4 protein, human; D016023:Integrins; D019718:Receptors, CXCR4; D017346:Protein Serine-Threonine Kinases; C505233:STK33 protein, human; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases
keywords: STK33; epithelial–mesenchymal transition; human large cell lung cancer; proliferation