title: One-pot synthesis of O-allylhydroxylamines through the organocatalytic oxidation of tertiary allylic amines followed by a [2,3]-meisenheimer rearrangement.
abstract: A cheap, green, and highly efficient one-pot method for the synthesis of O-protected allylic alcohols is described. By utilizing 2,2,2-trifluoroacetophenone as the organocatalyst and H2 O2 as the oxidant, a variety of allylic amine N-oxides were synthesized, which upon heating are converted to the final products through a [2,3]-Meisenheimer rearrangement.
authors: Laboratory of Organic of Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis 15771, Athens (Greece).
authors: Alexis
authors: A
authors: Theodorou
authors: Dimitris
authors: D
authors: Limnios
authors: Christoforos G
authors: CG
authors: Kokotos
keywords: alcohols; green chemistry; organocatalysis; oxidation; rearrangement