title: Immunological markers that predict radiation toxicity.
abstract: Radiotherapy is a major modality of cancer treatment responsible for a large proportion of cancer that is cured. Radiation exposure induces an inflammatory response which can be influenced by genetic, epigenetic, tumour, health and other factors which can lead to very different treatment outcomes between individuals. Molecules involved in the immunological response provide excellent potential biomarkers for the prediction of radiation-induced toxicity. The known molecular and cellular immunological responses in relation to radiation and the potential to improve cancer treatment are presented in this review. In particular, immunological biomarkers of radiation-induced fibrosis and pneumonitis in cancer radiotherapy patients are discussed.
authors: Centre for Innate Immunology and Infectious Disease, MIMR-PHI Institute of Medical Research, 27-31 Wright Street, Clayton, Vic. 3168, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Vic., Australia. Electronic address: carl.sprung@monash.edu.
authors: Carl N
authors: CN
authors: Sprung
authors: Centre for Innate Immunology and Infectious Disease, MIMR-PHI Institute of Medical Research, 27-31 Wright Street, Clayton, Vic. 3168, Australia; Department of Molecular and Translational Sciences, Monash University, Clayton, Vic., Australia.
authors: Helen B
authors: HB
authors: Forrester
authors: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
authors: Shankar
authors: S
authors: Siva
authors: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia; Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, Vic., Australia.
authors: Olga A
authors: OA
authors: Martin
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000532:radiotherapy*; D011237:Predictive Value of Tests; D011832:Radiation Injuries / Q000235:genetics / Q000276:immunology*; D011878:Radiotherapy / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarker; Immunology; Inflammation; Radiation sensitivity; Radiotherapy