title: Three-dimensional regulation of transcription.
abstract: Cells can adapt to environment and development by reconstructing their transcriptional networks to regulate diverse cellular processes without altering the underlying DNA sequences. These alterations, namely epigenetic changes, occur during cell division, differentiation and cell death. Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and non-coding RNAs (ncRNAs). Here, we highlight recent efforts on how the two latter epigenetic factors participate in the sophisticated transcriptional process and describe emerging techniques which permit us to uncover and gain insights into the fascinating genomic regulation.
authors: CAS Key Laboratory of Brain Function and Disease and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
authors: Jun
authors: J
authors: Cao
authors: Zhengyu
authors: Z
authors: Luo
authors: Qingyu
authors: Q
authors: Cheng
authors: Qianlan
authors: Q
authors: Xu
authors: Yan
authors: Y
authors: Zhang
authors: Fei
authors: F
authors: Wang
authors: Yan
authors: Y
authors: Wu
authors: Xiaoyuan
authors: X
authors: Song
mesh_terms: D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D022661:RNA, Untranslated