title: Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads.
abstract: Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects in procedures such as percutaneous vertebroplasty. With a view to the use of such cements for low load bearing applications such as sinus augmentation or filling extraction sites. However, the inclusion of certain species into bone cement formulations has the potential to diminish the mechanical properties of the formulations and thereby reduce their prospects for clinical translation. Consequently, we have prepared α-tricalcium phosphate (α-TCP)-based bone cements including materials that we would expect to improve their regenerative potential, and describe the mechanical properties of the resulting formulations herein. Formulations incorporated α-TCP, hydroxyapatite, biopolymer-thickened wetting agents, sutures, and platelet poor plasma. The mechanical properties of the composites were composition dependent, and optimized formulations had clinically relevant mechanical properties. Such calcium phosphate-based cements have potential as replacements for cements such as those based on polymethylmethacrylate.
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Reed
authors: R
authors: Harrison
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Zachary K
authors: ZK
authors: Criss
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Lacie
authors: L
authors: Feller
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Shan P
authors: SP
authors: Modi
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.|J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611-6131.
authors: John G
authors: JG
authors: Hardy
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.|J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611-6131.
authors: Christine E
authors: CE
authors: Schmidt
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Laura J
authors: LJ
authors: Suggs
authors: Department of Biomedical Engineering, The University of Texas at Austin, Texas, 78712.
authors: Matthew B
authors: MB
authors: Murphy
mesh_terms: D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry*; D006801:Humans; D013314:Stress, Mechanical
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate
keywords: biodegradable; biomaterials; composites; mineral