title: Fasting increases survival to cold in FOXO, DIF, autophagy mutants and in other genotypes of Drosophila melanogaster.
abstract: Fasting increases survival to a severe cold stress in young and middle-aged wild-type flies, this effect being lowered or absent at old age. As an attempt to determine the mechanisms of this effect, genes involved in metabolism (dFOXO), autophagy (Atg7), innate immunity (Dif (1) ), and resistance to cold (Frost) were studied. The 12 mutant, RNAi and control lines tested in this study displayed an increased survival to cold after fasting. This shows that fasting has a robust effect on survival to cold in many genotypes, but the mechanism of this effect remains unknown. This mechanism does not seem to be linked to metabolic pathways often considered to play a critical role in ageing and longevity determinations (insulin/insulin-like growth factor-1 pathway and autophagy).
authors: Centre de Recherches sur la Cognition Animale, UMR CNRS 5169, Université Paul Sabatier, 31062, Toulouse Cedex 9, France, eric.le-bourg@univ-tlse3.fr.
authors: Éric
authors: É
authors: Le Bourg
authors: Isabelle
authors: I
authors: Massou
mesh_terms: D000367:Age Factors; D000818:Animals; D001343:Autophagy; D000071193:Autophagy-Related Protein 7; D003080:Cold Temperature; D058639:Cold-Shock Response; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism; D005215:Fasting / Q000378:metabolism*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D007113:Immunity, Innate; D008297:Male; D009154:Mutation; D010641:Phenotype; D034622:RNA Interference; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C530193:Atg7 protein, Drosophila; D004268:DNA-Binding Proteins; C084428:Dif protein, Drosophila; D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors; C431557:Fst protein, Drosophila; D014157:Transcription Factors; D000071193:Autophagy-Related Protein 7