title: Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus.
abstract: Alzheimer's disease is the most common cause of dementia in the elderly. Although the primary cause of the disease is presently unknown, to date several risk factors have been described. Evidence suggests that one of these risk factors could be chronic stress. The aim of this work is to demonstrate that chronic stress is able to induce Alzheimer's disease features after the administration of nontoxic doses of sodium azide. We found that chronic stress increases the levels of several proteins involved in Alzheimer's disease pathogenesis, such as presenilin 1, presenilin 2, and S100β, besides inducing the aggregation of Tau, ubiquitin, and β-amyloid proteins in the hippocampus. More important, our work shows a synergistic effect of stress and sodium azide treatment leading to significant neuronal death in the mouse hippocampus. Our results point out that chronic stress is a risk factor contributing to amplify and accelerate Alzheimer's disease features in the hippocampus.
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: María José
authors: MJ
authors: Delgado-Cortés
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Ana M
authors: AM
authors: Espinosa-Oliva
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Manuel
authors: M
authors: Sarmiento
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Sandro
authors: S
authors: Argüelles
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Antonio J
authors: AJ
authors: Herrera
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Raquel
authors: R
authors: Mauriño
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Ruth F
authors: RF
authors: Villarán
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: José L
authors: JL
authors: Venero
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Alberto
authors: A
authors: Machado
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012-Sevilla, Spain.|Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013-Sevilla, Spain.
authors: Rocío M
authors: RM
authors: de Pablos
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019810:Sodium Azide / Q000494:pharmacology*; D013312:Stress, Physiological
chemical_list: D019810:Sodium Azide