title: A young leukemic patient with unusual catastrophic intestinal complication.
abstract: A 14-year-old child with acute lymphoblastic leukemia who had completed induction chemotherapy presented with fever and diffuse musculoskeletal pains which was thought to be a constellation of myositis, arthralgias and arthritis. Investigations revealed initially showed normal peripheral blood counts but had pancytopenia and pre-terminally blasts were seen in the peripheral blood smear. He had bone marrow necrosis. Disseminated intravascular coagulation was suspected with a positive fungal serology. At autopsy, he had evidence of disease relapsed in lymph nodes, liver, spleen, testes and kidneys. There was extensive pseudomembranous colitis and appendicitis with changes of toxic megacolon.
authors: Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors: Kim
authors: K
authors: Vaiphei
authors: Amita
authors: A
authors: Trehan
authors: Man Updesh Singh
authors: MU
authors: Sachdeva
authors: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors: Pankaj
authors: P
authors: Malhotra
mesh_terms: D000293:Adolescent; D001064:Appendicitis / Q000175:diagnosis / Q000473:pathology*; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008532:Megacolon, Toxic / Q000175:diagnosis / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis*