title: Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage.
abstract: This study describes an interesting observation that the mixture of anomeric galactolipids has synergistic effects on the growth inhibition of human multiple myeloma (MM) cells. We determine that the equivalent mixture of a pair of α- and β-galactolipids with a 14-carbon lipid chain can cause stronger poly ADP-ribose polymerase cleavage and DNA damage, producing more late apoptotic MM cells, than either anomer alone.
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
authors: Si-Si
authors: SS
authors: Deng
authors: Pediatric Intensive Care Unit, Jinan Children's Hospital, Jinan, 250022 Shangdong Province, PR China; Shandong University, Jinan, 250012 Shandong Province, PR China.
authors: Chao
authors: C
authors: Zhang
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China.
authors: Huan
authors: H
authors: Wang
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. Electronic address: yzang@mail.shcnc.ac.cn.
authors: Yi
authors: Y
authors: Zang
authors: National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
authors: Jia
authors: J
authors: Li
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China. Electronic address: xphe@ecust.edu.cn.
authors: Xiao-Peng
authors: XP
authors: He
authors: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China.
authors: Guo-Rong
authors: GR
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D004357:Drug Synergism; D038983:Galactolipids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D038983:Galactolipids; D011065:Poly(ADP-ribose) Polymerases
keywords: Anomer; Apoptosis; Glycolipid; Multiple myeloma; Synergism