title: Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome.
abstract: BACKGROUND
  Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.
  
  
  OBJECTIVE
  (1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.
  
  
  METHODS
  Randomized control trial from years 2010 to 2012.
  
  
  METHODS
  Tertiary care centre, Delhi, India.
  
  
  METHODS
  One-hundred and eighty pregnant women. Study population divided randomly into two groups: group A: nonintervention (60 women) and group B: intervention (120 women).
  
  
  METHODS
  The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.
  
  
  METHODS
  Risk of maternal complications such as preterm labour, pre-eclampsia and gestational diabetes associated with vitamin D deficiency and risk of low birthweight and poor Apgar score in infants of mothers with vitamin D deficiency.
  
  
  RESULTS
  Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46·11 ± 74·21 nmol/l vs 80 ± 51·53 nmol/l). Forty-four percent patients in group A and 20·3% patients in group B developed preterm labour/pre-eclampsia/gestational diabetes. Newborns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43·11 ± 81·32 nmol/l vs 56·8 ± 47·52 nmol/l). They also had lower birthweight of mean 2·4 ± 0·38 kg as compared to group B 2·6 ± 0·33 kg.
  
  
  CONCLUSIONS
  Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.
authors: Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Aanchal
authors: A
authors: Sablok
authors: Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Aruna
authors: A
authors: Batra
authors: Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Karishma
authors: K
authors: Thariani
authors: Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Achla
authors: A
authors: Batra
authors: Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Rekha
authors: R
authors: Bharti
authors: National Institute of Medical Statistics, All India Institute of Medical Sciences, New Delhi, India.
authors: Abha Rani
authors: AR
authors: Aggarwal
authors: Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: B C
authors: BC
authors: Kabi
authors: Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors: Harish
authors: H
authors: Chellani
mesh_terms: D001724:Birth Weight / Q000502:physiology; D015992:Body Mass Index; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000517:prevention & control; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D014807:Vitamin D