title: Improving QST Reliability--More Raters, Tests, or Occasions? A Multivariate Generalizability Study.
abstract: The reliability of quantitative sensory testing (QST) is affected by the error attributable to both test occasion and rater (examiner) and the interactions between them. Most reliability studies account for only 1 source of error. The present study employed a fully crossed, multivariate generalizability design to account for rater and occasion variance simultaneously. Nineteen healthy volunteers were examined with a battery of 7 QST procedures 4 times on 2 occasions by 2 raters. The QST battery was composed to include a mix of different pain stimuli and response domains, including threshold, intensity, tolerance, and modulation with mechanical, thermal, and chemical stimuli. The classical test-retest and interrater reliability (.19 < intraclass correlation coefficient <.92) was in line with the literature, and generalizability analysis indicated that the universe score was generally the dominant source of variation (relative contribution = 19%, 78%). Error attributable to the interaction between study participant and occasion was also influential. Dependability coefficients indicated that a substantial increase in reliability and feasibility could be achieved by employing a composite QST battery compared to single QST procedures. Reliability was improved more by repeated testing on separate occasions than by repeated testing by different raters.
  
  
  CONCLUSIONS
  When balancing reliability and feasibility, the current findings suggest that a carefully selected battery of QST procedures repeated on a few occasions may be optimal.
authors: Spine Center of Southern Denmark, Lillebælt Hospital, Middelfart, Denmark; Institute of Regional Health Science Research, University of Southern Denmark, Odense, Denmark. Electronic address: soeren.oneill@rsyd.dk.
authors: Søren
authors: S
authors: O'Neill
authors: Centre for Medical Education, Aarhus University, INCUBA Science Park Skejby, Århus N, Denmark.
authors: Lotte
authors: L
authors: O'Neill
mesh_terms: D000328:Adult; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000592:standards*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods*; D017288:Pain Threshold / Q000502:physiology*; D015203:Reproducibility of Results; D055815:Young Adult
keywords: Pain; generalizability; quantitative sensory testing; reliability; validity