title: IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals.
abstract: The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain.
authors: K
authors: K
authors: Machmach
authors: Immunology Service, Virgen del Rocío University Hospital, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: C
authors: C
authors: Abad-Molina
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain.
authors: M C
authors: MC
authors: Romero-Sánchez
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain.
authors: B
authors: B
authors: Dominguez-Molina
authors: Centro Regional de Transfusiones Sanguíneas Sevilla/Huelva y Banco de Tejidos, Seville, Spain.
authors: M
authors: M
authors: Moyano
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain.
authors: M M
authors: MM
authors: Rodriguez
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Department of Biochemistry and Molecular Biology & Immunology, Medical School, University of Seville, Seville, Spain.
authors: M
authors: M
authors: Rafii-El-Idrissi Benhnia
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: M E
authors: ME
authors: Jimenez-Mejias
authors: Hospital Universitari Joan XXIII, IISPV, Universitat Rovira I Virgili, Tarragona, Spain.
authors: F
authors: F
authors: Vidal
authors: Laboratory of Molecular Immuno-Biology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
authors: M A
authors: MA
authors: Muñoz-Fernández
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: M
authors: M
authors: Genebat
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: P
authors: P
authors: Viciana
authors: Immunology Service, Virgen del Rocío University Hospital, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: M F
authors: MF
authors: González-Escribano
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
authors: M
authors: M
authors: Leal
authors: Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain. Electronic address: ezequiel.ruizmateos@gmail.com.
authors: E
authors: E
authors: Ruiz-Mateos
mesh_terms: D000328:Adult; D000483:Alleles; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D060085:Coinfection; D003430:Cross-Sectional Studies; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D063868:Patient Outcome Assessment; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013030:Spain; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D007378:Interleukins; C579163:IFNL4 protein, human; D000095022:Interferon Lambda
keywords: AIDS; CD4; HIV infection; IFNL4; IL28B