title: Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage.
abstract: BACKGROUND
  Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate.
  
  
  METHODS
  Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department Umeå University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS).
  
  
  RESULTS
  Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point.
  
  
  CONCLUSIONS
  SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.
authors: Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden, Rickard.l.sjoberg@gmail.com.
authors: Rickard L
authors: RL
authors: Sjöberg
authors: Tommy
authors: T
authors: Bergenheim
authors: Lina
authors: L
authors: Mörén
authors: Henrik
authors: H
authors: Antti
authors: Cecilia
authors: C
authors: Lindgren
authors: Silvana
authors: S
authors: Naredi
authors: Peter
authors: P
authors: Lindvall
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005500:Follow-Up Studies; D023261:Glasgow Outcome Scale; D006801:Humans; D055442:Metabolome / Q000502:physiology*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers