title: [Analysis of prognosis in acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  The study was to investigate the prognosis factors in acute myeloid leukemia (AML) patients treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  
  
  METHODS
  The clinical information of 60 patients in our hospital was retrospectively analyzed and the prognosis factors of survival and relapse were explored by COX's proportional hazard model.
  
  
  RESULTS
  The elderly (HR = 4.530, P = 0.012), cGVHD (HR = 0.023, P = 0.003) and infection fungal disease (IFD) (HR = 4.019, P = 0.017) were influence factors for 2 year cumulative overall survival (OS). Response status (high risk vs low risk: HR = 3.465, P = 0.028), preconditioning regimens (TBI/Cy vs Bu/Cy: HR = 0.071, P = 0.012; FB vs Bu/Cy: HR = 7.547, P = 0.025) and cGVHD (HR = 0.088, P = 0.004) were influence factors for 2 year cumulative relapse rate (RR). cGVHD (P = 0.017) and IFD (P = 0.000) had an effect on OS after 2 years since allo-HSCT.
  
  
  CONCLUSIONS
  Age, response status, preconditioning regimens, cGVHD and IFD are closely associated with the prognosis of AML patients treated with allo-HSCT, and different patients need the individualized treatment.
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Xiao-Li
authors: XL
authors: Zhao
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Wen-Jun
authors: WJ
authors: Li
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Jie
authors: J
authors: Ding
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Hua-Ping
authors: HP
authors: Wei
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Yu
authors: Y
authors: Jing
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Hong-Hua
authors: HH
authors: Li
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Wen-Rong
authors: WR
authors: Huang
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China.
authors: Yu
authors: Y
authors: Zhao
authors: Medical College of Chinese PLA, Department of Hematology of Chinese PLA General Hospital, Beijing 100853, China. E-mail: gaochunji@hotmail.com.
authors: Chun-Ji
authors: CJ
authors: Gao
mesh_terms: D064591:Allografts; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies