title: Using neuroimaging to evaluate and guide pharmacological and psychotherapeutic treatments for mood disorders in children.
abstract: Mood disorders are increasing in childhood, and often require multimodal and comprehensive treatment plans to address a complex array of symptoms and associated morbidities. Pharmacotherapy, in combination with psychotherapeutic interventions, is essential for treatment and stabilization. Current evidence supports the use of a number of interventions in children and adolescents diagnosed with DSM-5 mood spectrum disorders, which are associated with impairments in prefrontal-striatal-limbic networks, which are key for emotional functioning and regulation. Yet, little is known about the neurobiological effects of interventions on the developing brain. This chapter provides a synopsis of the literature demonstrating the neural effects of psychotropic medications and psychotherapy in youth with depressive or bipolar spectrum disorders. Additional longitudinal and biological studies are warranted to characterize the effects of these interventions on all phases and stages of mood illness development in children and adolescents.
authors: Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,California,USA.
authors: Manpreet K
authors: MK
authors: Singh
authors: Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,California,USA.
authors: Amy S
authors: AS
authors: Garrett
authors: Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,California,USA.
authors: Kiki D
authors: KD
authors: Chang
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D001921:Brain / Q000254:growth & development / Q000503:physiopathology*; D002648:Child; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D059906:Neuroimaging; D011613:Psychotherapy; D011619:Psychotropic Drugs / Q000494:pharmacology*
chemical_list: D011619:Psychotropic Drugs
keywords: Bipolar disorder; MRI; depression; intervention; neuroimaging; pediatric