title: The prognostic value of additional malignant lesions detected by magnetic resonance imaging versus mammography.
abstract: BACKGROUND
  Nodal positivity is correlated with a poorer prognosis in breast cancer. A study was composed to compare nodal positivity in patients with single versus multiple lesions found on magnetic resonance imaging (MRI) and mammogram (MMG).
  
  
  METHODS
  A retrospective study of breast cancer patients undergoing MRI and MMG was performed. Nodal positivity was compared in patients with additional invasive lesions found on MRI versus single invasive lesions found on MRI and MMG.
  
  
  RESULTS
  A total of 425 patients were included. The overall nodal positivity was 23.8%. Patients with single versus multiple malignant lesions had nodal positivity of 20.9% vs 31.1% (P = .04). MRI detected multiple lesions in 120 patients, 80 of which were not detected by MMG (18.8%). Comparing single lesions with additional malignant lesions detected by MRI only, nodal positivity increased from 20.9% to 51.6% (P = .0002).
  
  
  CONCLUSIONS
  Patients with additional invasive lesions on MRI had significantly higher nodal positivity than single invasive lesions. Hence, addition of MRI in early-stage breast cancer may have prognostic value because of detection of potential node-positive patients.
authors: McLaren Flint, Flint, MI, USA. Electronic address: ssahadr@aol.com.
authors: Sukamal
authors: S
authors: Saha
authors: McLaren Macomb, Mt. Clemens, MI, USA.
authors: Mary
authors: M
authors: Freyvogel
authors: McLaren Macomb, Mt. Clemens, MI, USA.
authors: Gregory
authors: G
authors: Johnston
authors: McLaren Flint, Flint, MI, USA.
authors: Linda
authors: L
authors: Lawrence
authors: McLaren Flint, Flint, MI, USA.
authors: Chris
authors: C
authors: Conlin
authors: Regional Medical Imaging, Flint, MI, USA.
authors: Randy
authors: R
authors: Hicks
authors: Regional Medical Imaging, Flint, MI, USA.
authors: David
authors: D
authors: Strahle
authors: McLaren Flint, Flint, MI, USA.
authors: Alpesh
authors: A
authors: Korant
authors: Hurley Regional Medical Center, Flint, MI, USA.
authors: Mohammed
authors: M
authors: Shaik
authors: McLaren Flint, Flint, MI, USA.
authors: David
authors: D
authors: Wiese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies
keywords: MRI and breast cancer; Nodal positivity and MRI