title: Simvastatin does not reduce chemokine production in obesity without comorbidities.
abstract: Obesity is considered a subchronic inflammatory disease with high risk of comorbidity development. Obesity-associated inflammation originates from adipose tissue itself, which secretes a panel of inflammatory chemokines and cytokines. Therefore, we enrolled 23 obese women without comorbidity and evaluated if simvastatin 20 mg/day dose therapy for 6 weeks (n=15) may modulate plasma levels of inflammatory CXCL-10, CCL-2, CXCL-9, CXCL-8, and CCL-5. A significant decrease of cholesterol and its fractions, triglycerides, and high-sensitivity C-reactive protein (hsCRP) after simvastatin treatment was observed when compared to placebo (n=8). Chemokine plasma levels were unchanged by statin intake when compared to placebo. Although dyslipidemia biomarkers and hsCRP have been diminished by simvastatin, low chemokine amounts produced by healthy obese women do not seem to be altered by simvastatin anti-inflammatory activity.
authors: Núcleo de Pós-Graduação e Pesquisa - Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, Minas Gerais, Brazil.
authors: Karla Silva
authors: KS
authors: Fernandes
authors: Samantha Ribeiro
authors: SR
authors: Béla
authors: Vanessa L
authors: VL
authors: Andrade
authors: Tatiane Figueiredo
authors: TF
authors: de Moraes
authors: Olindo
authors: O
authors: de Assis Martins-Filho
authors: Valéria Cristina
authors: VC
authors: Sandrim
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D018932:Chemokine CCL2 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood; D054370:Chemokine CXCL9 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D016209:Interleukin-8 / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D019821:Simvastatin / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; C483024:CCL5 protein, human; C114753:CXCL10 protein, human; C508606:CXCL8 protein, human; C080810:CXCL9 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines; D000960:Hypolipidemic Agents; D016209:Interleukin-8; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D019821:Simvastatin