title: Biological evaluation of the effect of sugammadex on hemostasis and bleeding.
abstract: BACKGROUND
  Notification of sugammadex has been supplemented with a section on hemostasis, including a longer clotting time in the first minutes following injection, without any documented clinical consequences. The objective of this observational study was to analyze the effects of sugammadex administration on routine coagulation tests and bleeding in the clinical setting.
  
  
  METHODS
  After Institutional Review Board approval, a prospective observational study was conducted between January and December 2011. Adult patients scheduled for laparotomies were analyzed in groups according to the type of reversal (without sugammadex versus 2 or 4 mg/kg sugammadex). There were no changes in our current clinical practice. Blood samples drawn from these patients were standardized at the same time and tested using the same daily calibrated machine. The endpoint was a comparison of the activated partial thromboplastin time (aPTT), prothrombin time (PT), hemoglobin (Hb) level and hematocrit (Ht), immediately before sugammadex administration (H0) and 1 h after neuromuscular block reversal (H1).
  
  
  RESULTS
  One hundred and forty-two patients in three groups were included as follows: 11 in the "without sugammadex" group, 64 in the "2 mg/kg sugammadex" group and 67 in the "4 mg/kg sugammadex" group. Results did not differ significantly among the groups.
  
  
  CONCLUSIONS
  In this prospective observational study, the use of 2 and 4 mg/kg sugammadex was not associated with a longer clotting time or decreased hemoglobin concentrations. Future prospective investigations should study patients receiving 16 mg/kg sugammadex and/or with abnormal coagulation tests.
authors: Department of Anesthesiology, University of Nancy, Nancy, France.
authors: Julien
authors: J
authors: Raft
authors: Department of Anesthesiology, University of Nancy, Nancy, France. ; Department of Department of Anesthesiology, University of Nancy, Nancy, France.
authors: Philippe
authors: P
authors: Guerci
authors: Department of Biostatistics, Cancer Institut of Lorraine, University of Nancy, Nancy, France.
authors: Valentin
authors: V
authors: Harter
authors: Department of Department of Anesthesiology, University of Nancy, Nancy, France.
authors: Thomas
authors: T
authors: Fuchs-Buder
authors: Department of Anesthesiology, University of Nancy, Nancy, France. ; Department of Department of Anesthesiology, University of Nancy, Nancy, France.
authors: Claude
authors: C
authors: Meistelman
keywords: Activated partial thromboplastin time; Hemostasis; Prothrombin time; Sugammadex