title: Cardioembolic stroke is the most serious problem in the aging society: Japan standard stroke registry study.
abstract: BACKGROUND
  Japan has the fastest aging society in the world. Older patients have a different stroke risk profile and different stroke features compared with younger patients. The aim of the present study was to examine the stroke subtypes, risk factor profiles, stroke severities, and functional outcomes in the different age groups.
  
  
  METHODS
  A total of 78,096 patients with acute ischemic stroke, including transient ischemic attacks, were included in a multicenter, hospital-based registration study based on a computerized database involving 95 Japanese institutes between 2000 and 2012.
  
  
  RESULTS
  The frequency of atrial fibrillation increased even after the age of 90 years; consequently, the proportion of patients experiencing cardioembolic stroke also increased in the same age group. Furthermore, more severe symptoms on arrival and worse functional outcomes were observed with increasing age. The frequency of hypertension increased with age, peaking in patients in their 70s, and decreasing slightly thereafter. The frequency of diabetes mellitus and hyperlipidemia peaked in patients in their 50s or 60s and gradually decreased thereafter.
  
  
  CONCLUSIONS
  The findings of the present study suggest that in the currently aging society, cardioembolic stroke is the most important stroke subtype. The roles of hypertension, diabetes mellitus, and hyperlipidemia are greatest in stroke patients in their 50s to 60s. In older patients, the role of atrial fibrillation is more significant.
authors: Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Saitama, Japan. Electronic address: yujik@saitama-med.ac.jp.
authors: Yuji
authors: Y
authors: Kato
authors: Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Saitama, Japan.
authors: Takeshi
authors: T
authors: Hayashi
authors: Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Saitama, Japan.
authors: Norio
authors: N
authors: Tanahashi
authors: Department of Neurology, Shimane University, Shimane, Japan.
authors: Shotai
authors: S
authors: Kobayashi
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001281:Atrial Fibrillation / Q000453:epidemiology; D002545:Brain Ischemia / Q000150:complications* / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007564:Japan; D008297:Male; D012042:Registries / Q000592:standards*; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology*
keywords: Age stratification; Japanese; epidemiology; ischemic stroke