title: Ironing out VPS34 inhibition.
abstract: The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.
authors: Timothy
authors: T
authors: Marsh
authors: Jayanta
authors: J
authors: Debnath
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D002450:Cell Communication; D058546:Class III Phosphatidylinositol 3-Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D056918:Nuclear Receptor Coactivators / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011744:Pyrimidinones / Q000494:pharmacology
chemical_list: C000593572:1-((2-((2-chloropyridin-4yl)amino)-4'-(cyclopropylmethyl)-(4,5'-bipyrimidin)-2'-yl)amino)-2-methylpropan-2-ol; D000631:Aminopyridines; D047908:Intracellular Signaling Peptides and Proteins; C549756:NBR1 protein, human; C111382:NCOA4 protein, human; D056918:Nuclear Receptor Coactivators; D011506:Proteins; D011725:Pyridines; D011743:Pyrimidines; D011744:Pyrimidinones; C000594652:SAR405; D058546:Class III Phosphatidylinositol 3-Kinases