title: [Inhibitor influence on conditional food aversion long-term memory retention and reconsolidation in snail].
abstract: In snails trained for conditional food aversion, the effect of ZIP-protein kinase Mzeta (PKMzeta) inhibitor on mechanisms of memory retention and reconsolidation was studied. It was shown that two days after ZIP injections the dose of 1.25 mg/kg, which were not combined with a reminding procedure, there was no effects, but in dose of 2.5 mg/kg a transient memory impairment after 1 day after the injection with its spontaneous recovery on day 10 was disclosed. ZIP injection in a dose of 5 mg/kg without reminding procedure caused memory impairment and the development of persistent amnesia. During animal repeating training after 11 days after amnesia induction caused by ZIP in dose 5 mg/kg, the number of combined food and reinforcing stimulus needed for memory formation was similar to that seen in the initial training. ZIP in doses of 5 or 10 mg/kg combined with a reminding procedure caused the development of amnesia, however, repeating training after 11 days resulted in a dose-dependent and more rapid formation of memory than in the initial training. It was proposed that in snails trained to conditional food aversion without reminding procedure, inhibition of PKMzeta-like enzyme might cause "erase the memory trace" and in repeating training a new memory was formed. PKMzeta apparently not directly involved in the processes of memory reconsolidation, however, a reminding decreased amnesic effect of ZIP.
authors: V P
authors: VP
authors: Nikitin
authors: S V
authors: SV
authors: Solntseva
authors: S A
authors: SA
authors: Kozyrev
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D057567:Memory, Long-Term / Q000187:drug effects* / Q000502:physiology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D020127:Recovery of Function; D012054:Reinforcement, Psychology; D000099221:Protein Kinase C zeta
chemical_list: D011493:Protein Kinase C; D047428:Protein Kinase Inhibitors; D000099221:Protein Kinase C zeta