title: Synthesis and in vitro evaluation of a hyaluronic acid-quantum dots-melphalan conjugate.
abstract: Polymer-drug conjugates have played an important role in improving tumor cell targeting and the selectivity of anticancer drugs. In this study, quantum dots and melphalan were attached to the backbone of hyaluronic acid to synthesize a polymer-drug conjugate. The physicochemical properties of the conjugate were characterized by FT-IR, XRD, (1)H NMR, UV-Vis spectra and DLS. The in vitro drug release profiles and cell evaluation were investigated. The results showed that the conjugate was synthesized and self-assembled into nanoparticles with a diameter of 115 ± 2.3 nm. The conjugate had a pH-sensitive drug controlled release property. It was an ideal receptor-mediated delivery system and can be internalized into the human breast cancer cell. It had a better inhibition effect on human breast cancer cell and a poorer inhibition effect on normal breast cell than melphalan. These results supported that the conjugate would be a promising candidate for cancer therapy.
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Haixing
authors: H
authors: Xu
authors: The affiliated Baoan Hospital of Southern Medical University, Shenzhen 518101 PR China.
authors: Jingbo
authors: J
authors: He
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Yu
authors: Y
authors: Zhang
authors: Department of Chemical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Lihong
authors: L
authors: Fan
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Yaqiong
authors: Y
authors: Zhao
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Tengfei
authors: T
authors: Xu
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Zhuang
authors: Z
authors: Nie
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Xiangnan
authors: X
authors: Li
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Zhijun
authors: Z
authors: Huang
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China.
authors: Bo
authors: B
authors: Lu
authors: Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070 PR China. Electronic address: xhx040328@whut.edu.cn.
authors: Peihu
authors: P
authors: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001692:Biological Transport; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D065546:Drug Liberation; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D008558:Melphalan / Q000737:chemistry* / Q000494:pharmacology; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D006820:Hyaluronic Acid; D008558:Melphalan
keywords: Drug delivery system; Hyaluronic acid; Melphalan; Quantum dots