title: HLA-A*33:01 as protective allele for severe dengue in a population of Filipino children.
abstract: Dengue virus infection is a leading cause of morbidity among children in the Philippines in recent years. In order to investigate the association of HLA Class I and II alleles and dengue disease severity in a cohort of Filipino children, we performed a case control study in 2 hospitals in Metro Manila from June 2008 to December 2009. A total of 250 laboratory confirmed dengue patients and 300 healthy individuals aged 5 to 15 years old were typed for HLA-A, B and DRB1 alleles. The frequency of HLA-A*33:01 was significantly decreased in severe dengue (DHF/ DSS; Pc = 0.0016)) and DSS (Pc = 0.0032) compared to the background population. These findings support a previous study that this allele may confer protection against the severe form of dengue and provide the first evidence of HLA association with dengue in the Philippines. Future studies should be directed in investigating the possible mechanisms of protection.
authors: Molecular Biology Laboratory, Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Department of Immunogenetics, Global Center of Excellence (GCOE) program, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan.
authors: Edelwisa Segubre
authors: ES
authors: Mercado
authors: Medical Department, Research Institute for Tropical Medicine, Muntinlupa City, Philippines.
authors: Fe Esperanza
authors: FE
authors: Espino
authors: Office of Research Development, Philippine Children's Medical Center, Quezon City, Philippines.
authors: Ma Lucila M
authors: ML
authors: Perez
authors: Molecular Biology Laboratory, Research Institute for Tropical Medicine, Muntinlupa City, Philippines.
authors: Josie M
authors: JM
authors: Bilar
authors: Molecular Biology Laboratory, Research Institute for Tropical Medicine, Muntinlupa City, Philippines.
authors: Jemimah Dawn P
authors: JD
authors: Bajaro
authors: Department of Immunogenetics, Global Center of Excellence (GCOE) program, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan.
authors: Nguyen Tien
authors: NT
authors: Huy
authors: Office of Research Development, Philippine Children's Medical Center, Quezon City, Philippines.
authors: Benilda Q
authors: BQ
authors: Baello
authors: Department of Immunogenetics, Global Center of Excellence (GCOE) program, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan.
authors: Mihoko
authors: M
authors: Kikuchi
authors: Department of Immunogenetics, Global Center of Excellence (GCOE) program, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan.
authors: Kenji
authors: K
authors: Hirayama
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D010679:Philippines / Q000453:epidemiology; D012720:Severity of Illness Index
chemical_list: D015234:HLA-A Antigens; C082945:HLA-A*33 antigen