title: Deceased expression of prostatic acid phosphatase in primary sensory neurons after peripheral nerve injury.
abstract: Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons and functions as an ectonucleotidase that dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine to suppress pain via activating A1-adenosine receptor (A1R) in dorsal spinal cord. However, the effect of peripheral nerve injury on the expression of PAP has not been reported until now. In the present study we found that PAP expression in DRG neurons is significantly decreased from the 2nd day after peripheral nerve injury and reaches the bottom at the 14th. In addition, intrathecal PAP injection can reduce mechanical allodynia induced by spared nerve injury. Our findings suggest that the decrease of PAP is involved in pathophysiological mechanisms of neuropathic pain.
authors: The 2nd Department of Orthopaedics, 117 Hospital of PLA Hangzhou, China.
authors: Bo
authors: B
authors: Huang
authors: Yi Ji Shan Hospital of Wan Nan Medical College Anhui, China.
authors: Xia
authors: X
authors: Li
authors: General Hospital of Tibet Military Area command Tibet, China.
authors: Xiao-Chun
authors: XC
authors: Zhu
authors: The 2nd Department of Orthopaedics, 117 Hospital of PLA Hangzhou, China.
authors: Yi-Sheng
authors: YS
authors: Lu
mesh_terms: D000135:Acid Phosphatase / Q000096:biosynthesis*; D000818:Animals; D015536:Down-Regulation; D005727:Ganglia, Spinal / Q000201:enzymology; D006930:Hyperalgesia / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009437:Neuralgia / Q000201:enzymology*; D059348:Peripheral Nerve Injuries / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D060888:Real-Time Polymerase Chain Reaction; D011984:Sensory Receptor Cells / Q000201:enzymology*
chemical_list: D000135:Acid Phosphatase; C428439:prostatic acid phosphatase
keywords: DRG; PAP; neuropathic pain; peripheral nerve injury