title: Glucose and oxygen metabolism after penetrating ballistic-like brain injury.
abstract: Traumatic brain injury (TBI) is a major cause of death and disability in all age groups. Among TBI, penetrating traumatic brain injuries (PTBI) have the worst prognosis and represent the leading cause of TBI-related morbidity and death. However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI rat model: penetrating ballistic-like brain injury (PBBI). Early after injury, regional cerebral oxygen tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, glucose uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24 hours after PBBI revealed an incomplete overlap of metabolic impairment and neurodegeneration. As expected, the injury core had the most severe metabolic impairment and highest neurodegeneration. However, in the peri-lesional area, despite similar metabolic impairment, there was lesser neurodegeneration. Given our findings, the data suggest the presence of two distinct zones of primary injury, of which only one recovers. We anticipate the peri-lesional area encompassing the PBBI ischemic penumbra, could be salvaged by acute therapies.
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Shyam
authors: S
authors: Gajavelli
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Shimoda
authors: S
authors: Kentaro
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Julio
authors: J
authors: Diaz
authors: Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
authors: Shoji
authors: S
authors: Yokobori
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Markus
authors: M
authors: Spurlock
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Daniel
authors: D
authors: Diaz
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Clayton
authors: C
authors: Jackson
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Alexandra
authors: A
authors: Wick
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: Weizhao
authors: W
authors: Zhao
authors: Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
authors: Lai Y
authors: LY
authors: Leung
authors: Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
authors: Deborah
authors: D
authors: Shear
authors: Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
authors: Frank
authors: F
authors: Tortella
authors: Department of Neurosurgery, University of Miami, Miller School of Medicine, Miami, Florida, USA.
authors: M Ross
authors: MR
authors: Bullock
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism*; D020197:Head Injuries, Penetrating / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D008297:Male; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014948:Wounds, Gunshot / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D005947:Glucose; D010100:Oxygen