title: Gene expression defines natural changes in mammalian lifespan.
abstract: Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life-history traits, and identified the processes and pathways involved. These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.
authors: Department of Bioinspired Science, Ewha Womans University, Seoul, 120-750, South Korea.
authors: Alexey A
authors: AA
authors: Fushan
authors: Anton A
authors: AA
authors: Turanov
authors: Sang-Goo
authors: SG
authors: Lee
authors: Eun Bae
authors: EB
authors: Kim
authors: Alexei V
authors: AV
authors: Lobanov
authors: Sun Hee
authors: SH
authors: Yim
authors: Rochelle
authors: R
authors: Buffenstein
authors: Sang-Rae
authors: SR
authors: Lee
authors: Kyu-Tae
authors: KT
authors: Chang
authors: Hwanseok
authors: H
authors: Rhee
authors: Jong-So
authors: JS
authors: Kim
authors: Kap-Seok
authors: KS
authors: Yang
authors: Vadim N
authors: VN
authors: Gladyshev
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008322:Mammals; D008969:Molecular Sequence Data
keywords: aging; gene expression; life-history traits; lifespan; mammals