title: Partial remission of acute myeloid leukemia complicating multiple myeloma following COAP chemotherapy: A case report.
abstract: A 77-year-old male was admitted to hospital after complaining of fever and a cough for three days. A diagnosis of multiple myeloma was confirmed following M protein identification and a bone marrow biopsy. The patient received chemotherapy regimens of bortezomib plus dexamethasone, cyclophosphamide, thalidomide and dexamethasone, and thalidomide and dexamethasone, and was prescribed thalidomide (100 mg/d) to be taken orally for maintenance therapy. After a further two years the patient was subsequently diagnosed with acute myeloid leukemia. Chemotherapy regimens of cytarabine, aclacinomycin and daunorubicin, homoharringtonine and etoposide, and mitoxantrone and cytarabine resulted in no remission. Partial remission was obtained with a course of ifosfamide, vindesine, cytarabine and prednisone chemotherapy. This therapy may be an alternative treatment for secondary leukemia, particularly in elderly patients.
authors: Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China.
authors: Man
authors: M
authors: Shen
authors: Department of Hematology, The Second Artillery General Hospital, Beijing 100088, P.R. China.
authors: Wan-Jun
authors: WJ
authors: Sun
authors: Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China.
authors: Zhong-Xia
authors: ZX
authors: Huang
authors: Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China.
authors: Jia-Jia
authors: JJ
authors: Zhang
authors: Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China.
authors: Na
authors: N
authors: An
authors: Department of Hematology and Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, P.R. China.
authors: Xin
authors: X
authors: Li
keywords: COAP; acute myeloid leukemia; multiple myeloma; partial remission