title: Nanoadduct relieves: Alleviation of developmental toxicity of Cr(VI) due to its spontaneous adsorption to Mg(OH)2 nanoflakes.
abstract: During pregnancy, both the mother and fetus are vulnerable to environmental pollution by particulate matters and chemicals. Although the toxicity of free pollutants has been frequently reported, the impact of nanoparticle/pollutant adducts on the vulnerable pregnant population remains unclear. In this study, pregnant mice were orally exposed to Mg(OH)2 nanoflakes and nanoflakes adsorbed with Cr(VI) anions during the peri-implantation and organogenesis stages of pregnancy at doses that did not induce systemic toxicity or pregnancy complications. The nano-Mg(OH)2/Cr(VI) adducts formation reduced fetal developmental toxicity compared with the toxicity induced by the same concentration of free Cr(VI) anions.
authors: School of Public Health, Shandong University, Jinan, China.
authors: Zhiping
authors: Z
authors: Wang
authors: School of Public Health, Shandong University, Jinan, China.
authors: Chunhui
authors: C
authors: Li
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors: Yan
authors: Y
authors: Mu
authors: State Key Lab of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China.
authors: Zhang
authors: Z
authors: Lin
authors: School of Public Health, Shandong University, Jinan, China.
authors: Anji
authors: A
authors: Yi
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China. Electronic address: zhangqiu@sdu.edu.cn.
authors: Qiu
authors: Q
authors: Zhang
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China. Electronic address: drbingyan@yahoo.com.
authors: Bing
authors: B
authors: Yan
mesh_terms: D000327:Adsorption; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000196:embryology; D002857:Chromium / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D006965:Hyperplasia / Q000139:chemically induced; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000187:drug effects; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D010920:Placenta / Q000187:drug effects / Q000473:pathology; D000072483:Placenta Growth Factor; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood / Q000378:metabolism; D014018:Tissue Distribution; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism
chemical_list: C000608037:Pgf protein, mouse; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D002857:Chromium; D000072483:Placenta Growth Factor; C074702:chromium hexavalent ion; D008276:Magnesium Hydroxide
keywords: Developmental toxicity; Nano-Mg(OH)(2)/Cr(VI) adduct; Pregnant mice