title: [Sleep problems in dementia].
abstract: Sleep disturbance is common in patients with dementia. Circadian rhythm sleep disorders are caused by the disturbance of sleep-wake regulation in the central nervous system, disturbed input into the sensory organs, and decreased social activities. Diurnal change of serum melatonin level in Alzheimer's disease showed decreased amplitude and shifted peak secretion. Age related sleep disturbances and sleep disorders due to the neurodegeneration including REM sleep behavior disorder also increase in dementia. Identifying and treating underlying sleep disorders along with therapeutic approach to circadian mechanism is effective. Treatment of circadian abnormality in dementia require light therapy and increased daytime activity. Use of oral melatonin is also effective for the improvement of nocturnal sleep. Treatment of sleep problems in dementia also contribute to the better management of dementia.
authors: Center for Sleep Medicine, Ehime University Hospital.
authors: Yasunori
authors: Y
authors: Oka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D021081:Chronobiology Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D002940:Circadian Rhythm; D003704:Dementia / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008550:Melatonin / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
chemical_list: D008550:Melatonin