title: A nuclear option that initiates autophagy.
abstract: In this issue of Molecular Cell, Huang et al. (2015) describe a nuclear pool of LC3 that is deacetylated during starvation, leading to redistribution of this essential autophagy regulator to the cytoplasm, where it can initiate autophagy.
authors: Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA.
authors: Lyndsay
authors: L
authors: Murrow
authors: Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: jayanta.debnath@ucsf.edu.
authors: Jayanta
authors: J
authors: Debnath
mesh_terms: D001343:Autophagy; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*
chemical_list: C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D008239:Lysine