title: [The epithelial-mesenchymal transition and fibrosis of the renal transplant].
abstract: Epithelial-mesenchymal transition (EMT) is a process by which differentiated epithelial cells undergo a phenotypic conversion and acquire a mesenchymal phenotype, including elongated morphology, enhanced migratory and invasion capacity, and greatly increased production of extracellular matrix (ECM) components. This phenomenon plays a pivotal role in embryonic development, wound healing and tissue regeneration. It has also been involved in organ fibrosis. Some studies suggest that following injury, renal tubular epithelial cells undergo reprograming in mesenchymal cells, and thus constitute an important source of de novo myofibroblasts invading the renal interstitium and contributing to fibrosis. However, an increasing number of studies raise doubts about the existence of this process in vivo. The role of EMT in the development of renal fibrosis remains a matter of intense debate and may depend on the model studied. In this review, we describe the role of EMT in the development of fibrosis of renal graft, and then we propose approaches for detecting and treating renal fibrogenesis by targeting TEM.
authors: Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie.
authors: Imen
authors: I
authors: Mezni
authors: Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - urgences néphrologiques et transplantation rénale, APHP, hôpital Tenon, Paris, France.
authors: Pierre
authors: P
authors: Galichon
authors: laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie - service de médecine interne A, EPS Charles Nicolle, Tunis, Tunisie.
authors: Mohamed Mongi
authors: MM
authors: Bacha
authors: laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie.
authors: Imen
authors: I
authors: Sfar
authors: Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - urgences néphrologiques et transplantation rénale, APHP, hôpital Tenon, Paris, France.
authors: Alexandre
authors: A
authors: Hertig
authors: laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie - service de médecine interne A, EPS Charles Nicolle, Tunis, Tunisie.
authors: Rim
authors: R
authors: Goucha
authors: Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France.
authors: Yi-Chun
authors: YC
authors: Xu-Dubois
authors: service de médecine interne A, EPS Charles Nicolle, Tunis, Tunisie.
authors: Ezzedine
authors: E
authors: Abderrahim
authors: laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie.
authors: Yousr
authors: Y
authors: Gorgi
authors: Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - urgences néphrologiques et transplantation rénale, APHP, hôpital Tenon, Paris, France.
authors: Eric
authors: E
authors: Rondeau
authors: laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie - service de médecine interne A, EPS Charles Nicolle, Tunis, Tunisie.
authors: Taieb Ben
authors: TB
authors: Abdallah
mesh_terms: D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005355:Fibrosis / Q000209:etiology / Q000628:therapy; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D058990:Molecular Targeted Therapy