title: Associations of cadmium, bisphenol A and polychlorinated biphenyl co-exposure in utero with placental gene expression and neonatal outcomes.
abstract: In utero co-exposure to endocrine disrupting compounds can perturb fetal development. However, the effect of co-exposure on pivotal regulatory genes has seldom been investigated. We explored the effects of in utero co-exposure to cadmium (Cd), bisphenol A (BPA) and polychlorinated biphenyls (PCBs) on master regulator genes. We recruited 284 healthy pregnant women, of whom 262 provided both cord blood and placenta samples, and 200 had all measurements taken. Placental Cd, cord blood BPA and total PCBs in the exposed group were higher than a reference group. KISS1 expression level in placental tissue was threefold higher in the exposed group than in the reference, and was positively associated with all toxicants. Leptin and leptin receptor expression were also significantly higher, but were only associated with BPA. From our findings, we conclude that lower birth weight is correlated with Cd and PCBs, and may result from the increased KISS1 mRNA expression.
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, China.
authors: Xijin
authors: X
authors: Xu
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China.
authors: Yin Mei
authors: YM
authors: Chiung
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China.
authors: Fangfang
authors: F
authors: Lu
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China.
authors: Shaoshan
authors: S
authors: Qiu
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China.
authors: Minhui
authors: M
authors: Ji
authors: Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong, China. Electronic address: xhuo@stu.edu.cn.
authors: Xia
authors: X
authors: Huo
mesh_terms: D001559:Benzhydryl Compounds / Q000097:blood / Q000633:toxicity*; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D059648:Kisspeptins / Q000235:genetics; D020738:Leptin / Q000235:genetics; D008297:Male; D010636:Phenols / Q000097:blood / Q000633:toxicity*; D010920:Placenta / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012333:RNA, Messenger / Q000032:analysis; D054411:Receptors, Leptin / Q000235:genetics; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002104:Cadmium; D059648:Kisspeptins; D020738:Leptin; D010636:Phenols; D011078:Polychlorinated Biphenyls; D012333:RNA, Messenger; D054411:Receptors, Leptin; C106628:KISS1 protein, human; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Birth outcomes; Endocrine disrupting compounds; KISS1 expression; Prenatal exposure