title: Exercise in pregnancy does not alter gestational weight gain, MCP-1 or leptin in obese women.
abstract: BACKGROUND
  Increasing physical activity in pregnancy may improve pregnancy outcomes for obese women. Exercise could reduce gestational weight gain, improve the maternal circulating lipid profile as well as alter leptin, Interleukin-8 (IL-8) and Monocyte Chemoattractant Protein-1 (MCP-1) levels.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effects of exercise on gestational weight gain, maternal circulating lipids, IL-8, MCP-1 and leptin levels in obese pregnant women.
  
  
  METHODS
  The analysis was performed in the 35 obese women enrolled in the pilot BAMBINO randomised controlled trial who provided blood samples at 12- and 28-weeks gestation. Women in the exercise intervention arm received an individualised exercise plan. Blood samples, exercise diary and pedometer data were obtained at 12-, 20-, 28- and 36-weeks' gestation. Cord blood was obtained at delivery.
  
  
  RESULTS
  Women in the exercise arm exercised more than those in the control arm (P = 0.038). There was no difference in gestational weight gain, excess gestational weight gain, MCP-1 and leptin levels between women in the exercise intervention (n = 19) or the control arm (n = 16). IL-8 was not detectable. Exercise did not alter the maternal lipid profile.
  
  
  CONCLUSIONS
  The low level of physical activity achieved in obese women in the exercise intervention arm was insufficient to alter gestational weight gain, MCP-1, leptin or circulating lipid levels.
authors: School of Medicine, The University of Queensland, Herston, Queensland, Australia; UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.
authors: Marloes
authors: M
authors: Dekker Nitert
authors: Helen L
authors: HL
authors: Barrett
authors: Kerina J
authors: KJ
authors: Denny
authors: H David
authors: HD
authors: McIntyre
authors: Leonie K
authors: LK
authors: Callaway
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000628:therapy; D010865:Pilot Projects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000517:prevention & control; D015430:Weight Gain; D055815:Young Adult
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016209:Interleukin-8; D020738:Leptin
keywords: exercise; gestational weight gain; lipids; obesity; pregnancy