title: Feedback stabilizes propagation of synchronous spiking in cortical neural networks.
abstract: Precisely timed action potentials related to stimuli and behavior have been observed in the cerebral cortex. However, information carried by the precise spike timing has to propagate through many cortical areas, and noise could disrupt millisecond precision during the transmission. Previous studies have demonstrated that only strong stimuli that evoke a large number of spikes with small dispersion of spike times can propagate through multilayer networks without degrading the temporal precision. Here we show that feedback projections can increase the number of spikes in spike volleys without degrading their temporal precision. Feedback also increased the range of spike volleys that can propagate through multilayer networks. Our work suggests that feedback projections could be responsible for the reliable propagation of information encoded in spike times through cortex, and thus could serve as an attentional mechanism to regulate the flow of information in the cortex. Feedback projections may also participate in generating spike synchronization that is engaged in cognitive behaviors by the same mechanisms described here for spike propagation.
authors: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037; Institute for Neural Computation, University of California, San Diego, La Jolla, CA 92093;
authors: Samat
authors: S
authors: Moldakarimov
authors: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037; Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521; and.
authors: Maxim
authors: M
authors: Bazhenov
authors: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037; Institute for Neural Computation, University of California, San Diego, La Jolla, CA 92093; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 terry@salk.edu.
authors: Terrence J
authors: TJ
authors: Sejnowski
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D025461:Feedback, Physiological; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000502:physiology
keywords: attention; cerebral cortex; neural coding; spike timing; synfire