title: Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study.
abstract: We performed a retrospective cohort study of hospitalised cryptococcal meningitis (CM) patients at a single centre to evaluate the clinical epidemiological features of paradoxical cryptococcal-related immune reconstitution inflammatory syndrome (CM-IRIS) in a setting in China. A total of 154 AIDS patients with CM were involved, and 17.5% experienced IRIS at a median of 27 days after initiation of antiretroviral therapy (ART). Overall, 3 deaths were directly attributed to IRIS. The occurrences of CM-IRIS were independently associated with the pre-ART CD4+count, pre-C-reactive protein level, and the timing of ART initiation.
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: S
authors: S
authors: Yan
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China. Electronic address: 442696008@qq.com.
authors: L
authors: L
authors: Chen
authors: Hunan Provincial Tumor Hospital, Changsha, China.
authors: W
authors: W
authors: Wu
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Z
authors: Z
authors: Li
authors: Centers for Disease Control and Prevention of Hunan Province, China.
authors: Z
authors: Z
authors: Fu
authors: Centers for Disease Control and Prevention of Changsha City, Hunan Province, China.
authors: H
authors: H
authors: Zhang
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: J
authors: J
authors: Xue
authors: Hunan Provincial Tumor Hospital, Changsha, China.
authors: Y
authors: Y
authors: Hu
authors: Changsha Medical University, Hunan Province, China.
authors: J
authors: J
authors: Mou
authors: Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
authors: C
authors: C
authors: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D002097:C-Reactive Protein / Q000032:analysis; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006761:Hospitals; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications*; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; D002097:C-Reactive Protein
keywords: ART; HIV/AIDS; IRIS; cryptococcal meningitis; predictors