title: Effect of cod liver oil supplementation on the stearoyl-CoA desaturase index in obese children: a pilot study.
abstract: To investigate the effects of n-3 polyunsaturated fatty acids on stearoyl-CoA desaturase (SCD) activity, we treated 10 obese children (mean age: 12.9 years) with cod liver oil once daily for 12 weeks. The effects of cod liver oil supplementation on SCD activity, as estimated by the palmitoleate/palmitate ratio, depended on the docosahexaenoic acid (DHA) contents at baseline. Baseline DHA contents were negatively correlated with baseline SCD activity. After the treatment, baseline DHA contents were found to be significantly associated with the reduction of SCD activity. Cod liver oil supplementation may be a complementary treatment for obese children with low baseline contents of DHA.
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Yukihiko
authors: Y
authors: Fujita
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan. Electronic address: tomo@med.email.ne.jp.
authors: Tomoo
authors: T
authors: Okada
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Yuriko
authors: Y
authors: Abe
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Minako
authors: M
authors: Kazama
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Emiko
authors: E
authors: Saito
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Yuki
authors: Y
authors: Kuromori
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Fujihiko
authors: F
authors: Iwata
authors: Department of Pediatrics, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo 163-8001, Japan.
authors: Mitsuhiko
authors: M
authors: Hara
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Mamoru
authors: M
authors: Ayusawa
authors: Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1, Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
authors: Hiroyuki
authors: H
authors: Izumi
authors: Nutritional Science Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City, Kanagawa 228-8583, Japan.
authors: Yohei
authors: Y
authors: Kitamura
authors: Nutritional Science Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama City, Kanagawa 228-8583, Japan.
authors: Takashi
authors: T
authors: Shimizu
mesh_terms: D002648:Child; D003060:Cod Liver Oil / Q000627:therapeutic use*; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D063766:Pediatric Obesity / Q000097:blood / Q000178:diet therapy*; D010743:Phospholipids / Q000097:blood* / Q000737:chemistry; D010865:Pilot Projects; D013230:Stearoyl-CoA Desaturase / Q000097:blood* / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D010743:Phospholipids; D004281:Docosahexaenoic Acids; D003060:Cod Liver Oil; D013230:Stearoyl-CoA Desaturase
keywords: Cod liver oil supplementation; Docosahexaenoic acid (DHA); Obese children; Stearoyl-CoA desaturase index