title: Diurnal and seasonal occurrence of febrile seizures.
abstract: BACKGROUND
  Febrile seizures are the most common seizures in children, but their pathogenesis remains unknown. Some studies have suggested an association between the light-dependent secretion of melatonin and the occurrence of febrile seizures. The diurnal and seasonal occurrence of febrile seizures could clarify the role daylight plays in febrile seizures.
  
  
  METHODS
  In Finland, summer days are long and bright and winter days are short and dark. We evaluated the diurnal and seasonal occurrence of the first febrile seizures in 461 children and adjusted them according to the epidemiology of the febrile episodes in a population-based study of 1522 children.
  
  
  RESULTS
  The first febrile seizure most often occurred in the evening, peaking between 6 and 10 PM (31%), and least often at night, in the early morning hours between 2 and 6 AM (8%) (P < 0.001). This diurnal pattern repeated itself in different seasons according to variance in daylight duration. Febrile seizures occurred irregularly throughout the year, most frequently in winter, concurrently with the febrile episodes, and least frequently in summer; this seasonal variation in the occurrence of febrile seizures disappeared however when adjusted for the number of febrile events.
  
  
  CONCLUSIONS
  We found clear diurnal and seasonal variations in the occurrence of febrile seizures, even though they did not follow the amount of daylight. Our findings do not support the hypothesis that the diurnal and seasonal variation of daylight explains the occurrence of febrile seizures. Moreover, febrile events associated strongly with the occurrence of febrile seizures.
authors: Department of Pediatrics, University of Oulu, Oulu, Finland. Electronic address: kirsi.h.mikkonen@hus.fi.
authors: Kirsi
authors: K
authors: Mikkonen
authors: Department of Pediatrics, University of Oulu, Oulu, Finland.
authors: Matti
authors: M
authors: Uhari
authors: Department of Pediatrics, University of Oulu, Oulu, Finland.
authors: Tytti
authors: T
authors: Pokka
authors: Department of Pediatrics, University of Oulu, Oulu, Finland.
authors: Heikki
authors: H
authors: Rantala
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D017440:Photoperiod; D012621:Seasons; D003294:Seizures, Febrile / Q000453:epidemiology*
keywords: children; daylight; diurnal variation; febrile seizure; melatonin; seasonal variation