title: Mycobacterium chelonae cutaneous infection in a patient with mixed connective tissue disease.
abstract: Around 50 mycobacteria species cause human disease. Immunosuppressive states predispose to non-tuberculous mycobaterium infection, such as Mycobacterium chelonae: AFB, non-tuberculous, fast growth of low virulence and uncommon as a human pathogen. It may compromise the skin and soft tissues, lungs, lymph nodes and there is also a disseminated presentation. The diagnosis involves AFB identification and culture on Agar and Lowenstein-Jensen medium base. A 41-year-old female with MCTD (LES predominance) is reported, presenting painless nodules in the right forearm. She denied local trauma. Immunosuppressed with prednisone and cyclophosphamide for 24 months. Lesion biopsy has demonstrated positive bacilloscopy (Ziehl-Neelsen stain) and M.chelonae in culture (Lowenstein-Jensen medium base), therefore clarithromycin treatment has been started (best therapy choice in the literature).
authors: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors: Renan
authors: R
authors: Lage
authors: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors: Danilo Guerreiro Zeolo
authors: DG
authors: Biccigo
authors: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors: Felipe Borba Calixto
authors: FB
authors: Santos
authors: Instituto Adolfo Lutz, São Paulo, SP, Brazil.
authors: Erica
authors: E
authors: Chimara
authors: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors: Elisangela Samartin Pegas
authors: ES
authors: Pereira
authors: Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors: Adilson da
authors: Ad
authors: Costa
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000188:drug therapy*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D016926:Mycobacterium chelonae / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D017291:Clarithromycin