title: Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome.
abstract: Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons. Abnormal concentrations of plasma lipids can result from changes in the production, conversion, or catabolism of lipoprotein particles. Whereas the liver is involved in controlling serum lipid levels through synthesis of liver derived triglyceride-rich lipoproteins and low-density lipoprotein metabolism, the intestine also has a major role in lipoprotein production. Postprandial lipemia results from increases in apoB-48 availability, lipogenesis, and the synthesis and absorption of cholesterol in the enterocytes. Increased intestinal lipoprotein production prolongs postprandial lipemia in patients with diabetes and MetS, and may contribute directly to atherogenesis in these patients.
authors: Department of Internal Medicine and Medical Specialties, UOS Atherosclerosis Center, La Sapienza University of Rome, Rome, Italy. Electronic address: marcello.arca@uniroma1.it.
authors: Marcello
authors: M
authors: Arca
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D007413:Intestinal Mucosa / Q000378:metabolism*; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism*; D019518:Postprandial Period; D013997:Time Factors
chemical_list: D008074:Lipoproteins; D002784:Cholesterol
keywords: Cholesterol metabolism; Diabetes mellitus; Intestine; Metabolic syndrome; Postprandial lipemia