title: The Time of Spontaneous Resolution of Monosymptomatic Nocturnal Enuresis (MNE) Is Familial.
abstract: OBJECTIVE
  To investigate whether or not the age of spontaneous resolution of monosymptomatic nocturnal enuresis (MNE) was familial.
  
  
  METHODS
  A questionnaire was administered to more than 1,500 people, and 100 appropriate participants were identified from four referral hospitals. We included the participants who had MNE and whose parents also had MNE with spontaneous resolution. Then the association between the spontaneous resolution time of MNE in parents and that in their children was investigated.
  
  
  RESULTS
  The mean ages of spontaneous resolution were 10.7 (10-30 years), 9.4 (6-17 years) and 10.9 (6-18 years) in participants, their mothers and their fathers, respectively. According to the statistical analysis, there was a positive correlation between participants and both their mothers and fathers (p < 0.05). In addition, it was revealed that familial MNE history based on first- and second-degree relatives, in addition to their parents, was also associated with the increased spontaneous resolution age of MNE (p < 0.05). According to our results, gender and parents' education status were not statistically associated with the spontaneous resolution (p > 0.05).
  
  
  CONCLUSIONS
  As a conclusion, the age of spontaneous resolution of MNE is familial. Although the exact reasons of spontaneous resolution still remain a mystery; further genetic investigations may be able to resolve this mystery.
authors: Giresun University, School of Medicine, Department of Urology, Giresun, Turkey.
authors: Ural
authors: U
authors: Oguz
authors: Aykut
authors: A
authors: Aykac
authors: Erhan
authors: E
authors: Demirelli
authors: Eyup Burak
authors: EB
authors: Sancak
authors: Berkan
authors: B
authors: Resorlu
authors: Selcuk
authors: S
authors: Sarikaya
authors: Erman
authors: E
authors: Damar
authors: Omer Faruk
authors: OF
authors: Bozkurt
authors: Ercan
authors: E
authors: Ogreden
authors: Orhan
authors: O
authors: Yalcin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D040941:Heredity; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D010641:Phenotype; D012075:Remission, Spontaneous; D011795:Surveys and Questionnaires; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult