title: Radiographic and clinical outcomes in cavernous carotid fistula with special focus on alternative transvenous access techniques.
abstract: Carotid cavernous fistulae (CCF) are dangerous entities that may cause progressive cranial neuropathy, headache and blindness. Endovascular therapy for CCF is the treatment of choice and can be accomplished with minimal morbidity, but optimal treatment strategies vary according to CCF anatomy. We aimed to define a tailored endovascular treatment algorithm for CCF with a focus on traditional and aberrant venous anatomy. Retrospective cohort analysis of data for 57 patients (age range, 18-90 years, mean 53 years) with CCF (35 direct, 22 indirect) was performed. Treatment was transarterial (n=31), transvenous (n=18), combined (n=2), or observation (n=6). Non-conventional transvenous access (that is, via the facial vein, pterygoid plexus, or via direct puncture of the inferior ophthalmic or frontal vein) was employed in five patients. Mean follow-up period was 12 months. Radiographic cure rate in treated CCF was 96%. Forty-five patients presented with ophthalmic symptoms (chemosis, proptosis, eye pain); all resolved within 6 weeks of successful treatment. Forty-three patients presented with cranial nerve III, IV and/or VI palsy; complete recovery was seen in 54% and partial recovery in 18%. Five patients presented with blindness and five with declining visual acuity. No patient with blindness regained sight after treatment, but all five patients with declining vision recovered some visual acuity. The complication rate was 10.6% (one transient abducens nerve palsy, two symptomatic cerebral infarctions, and three groin hematomas). The permanent complication rate was 3.5%. Multimodal treatment of CCF, including non-traditional routes of transvenous access, results in excellent outcomes and low morbidity.
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA. Electronic address: rymorton@uw.edu.
authors: Ryan P
authors: RP
authors: Morton
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA.
authors: Farzana
authors: F
authors: Tariq
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA.
authors: Michael R
authors: MR
authors: Levitt
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA.
authors: John D
authors: JD
authors: Nerva
authors: Department of Radiology, University of Washington at Harborview Medical Center, Seattle, WA, USA.
authors: Mahmud
authors: M
authors: Mossa-Basha
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA.
authors: Laligam N
authors: LN
authors: Sekhar
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA; Department of Radiology, University of Washington at Harborview Medical Center, Seattle, WA, USA.
authors: Louis J
authors: LJ
authors: Kim
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA; Department of Radiology, University of Washington at Harborview Medical Center, Seattle, WA, USA.
authors: Danial K
authors: DK
authors: Hallam
authors: Department of Neurological Surgery, University of Washington at Harborview Medical Center, Box 359766, 325 9th Avenue, Seattle, WA 98104, USA; Department of Radiology, University of Washington at Harborview Medical Center, Seattle, WA, USA.
authors: Basavaraj V
authors: BV
authors: Ghodke
mesh_terms: D020434:Abducens Nerve Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D020216:Carotid-Cavernous Sinus Fistula / Q000000981:diagnostic imaging* / Q000601:surgery*; D015331:Cohort Studies; D003389:Cranial Nerve Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods; D057510:Endovascular Procedures / Q000009:adverse effects / Q000379:methods*; D005094:Exophthalmos / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Carotid cavernous sinus fistula; Therapeutic embolization; Transarterial; Transvenous