title: Sequential decarboxylative azide-alkyne cycloaddition and dehydrogenative coupling reactions: one-pot synthesis of polycyclic fused triazoles.
abstract: Herein, we describe a one-pot protocol for the synthesis of a novel series of polycyclic triazole derivatives. Transition metal-catalyzed decarboxylative CuAAC and dehydrogenative cross coupling reactions are combined in a single flask and achieved good yields of the respective triazoles (up to 97% yield). This methodology is more convenient to produce the complex polycyclic molecules in a simple way.
authors: PG and Research Department of Chemistry, Jamal Mohamed College, affiliated to the Bharathidasan university, Thiruchirapalli - 620020, Tamilnadu, India ; Orchid Chemicals & Pharmaceuticals Ltd, Drug Discovery Research, R&D Center, Sholinganallur, Chennai - 600119, India.
authors: Kuppusamy
authors: K
authors: Bharathimohan
authors: Inogent Laboratories Pvt Ltd, API R&D, 28A, IDA, Nacharam, Hyderabad-500076, India.
authors: Thanasekaran
authors: T
authors: Ponpandian
authors: PG and Research Department of Chemistry, Jamal Mohamed College, affiliated to the Bharathidasan university, Thiruchirapalli - 620020, Tamilnadu, India.
authors: A Jafar
authors: AJ
authors: Ahamed
authors: X-ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States.
authors: Nattamai
authors: N
authors: Bhuvanesh
keywords: copper(II) acetate; decarboxylative CuAAC; dehydrogenative coupling; fused triazoles; one-pot synthesis