title: Orthoptic and video-oculographic analyses in oculopharyngeal muscular dystrophy.
abstract: BACKGROUND
  Mild ophthalmoparesis can be seen in oculopharyngeal muscular dystrophy (OPMD).
  
  
  METHODS
  Orthoptic analysis included assessment of phoria/tropia, eye excursion, saccades, pursuit, stereoacuity, and Hess-Lancaster screen test. Video-oculography included fixation, horizontal and vertical saccades, and pursuit.
  
  
  RESULTS
  Orthoptic abnormalities were: tropia (4 of 6); abnormal eye excursion (4 of 6, 78% involved lateral or superior rectus muscles); abnormal horizontal or vertical saccades (2 of 6); abnormal pursuit (0 of 6); abnormal stereoacuity (2 of 6); and pathological Hess-Lancaster screen (4 of 6). Video-oculographic abnormalities were present for: fixation (1 of 6); saccade latency (1 of 6); horizontal pursuit (3 of 6); and vertical pursuit (0 of 6). For horizontal saccades, mean velocity, peak velocity, and gain were pathological in 5 of 6, 5 of 6 (61% of pathological mean and peak velocities involved abducting eye movements), and 3 of 6, respectively. For vertical saccades, mean velocity, peak velocity, and gain were pathological in 4 of 6, 4 of 6 (53% involved upward movements), and 3 of 6, respectively.
  
  
  CONCLUSIONS
  The data indicate preferential involvement of lateral and (to a lesser degree) superior rectus muscles in OPMD.
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Dimitri
authors: D
authors: Renard
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Adelaide
authors: A
authors: Ferraro
authors: Department of Ophthalmology, CHU Nîmes, Hôpital Caremeau, Nîmes, France.
authors: Marie-Celine
authors: MC
authors: Lorenzini
authors: Department of Ophthalmology, CHU Nîmes, Hôpital Caremeau, Nîmes, France.
authors: Luc
authors: L
authors: Jeanjean
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Marie-Claire
authors: MC
authors: Portal
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Elisabeth
authors: E
authors: Llinares
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Pierre
authors: P
authors: Labauge
authors: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors: Giovanni
authors: G
authors: Castelnovo
mesh_terms: D000368:Aged; D004585:Electrooculography; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D039141:Muscular Dystrophy, Oculopharyngeal / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D009988:Orthoptics / Q000379:methods*; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D014741:Video Recording
keywords: oculomotor; oculopharyngeal muscular dystrophy; ophthaloparesis; orthoptic; video-oculography