title: Age influences the clinical significance of atypical glandular cells on cytology.
abstract: OBJECTIVE
  To evaluate women with atypical glandular cells (AGC) or adenocarcinoma in situ (AIS) on cytology.
  
  
  METHODS
  Population-based data of cervical smears taken between 2008-2012 were analyzed.
  
  
  RESULTS
  Cancer was diagnosed in 107 out of 199 patients (54%) with AGC or AIS; 30 with cervical adenocarcinoma and 77 with endometrial cancer. All women with endometrial cancer were 50 years or older. In women younger than 50 years, cervical pre-cancerous lesions were found in 44 (47%) and cervical adenocarcinoma in 24 out of 92 cases (26%). High-risk HPV infection was found in 62 out of 103 women (60%). The detection rate of high-risk HPV at finding histopathological AGC, AIS, low-grade squamous intraepithelial lesions, high-grade squamous intraepithelial lesions or cervical cancer was 98% (95% confidence interval=0.903-1.000) (54/55).
  
  
  CONCLUSIONS
  AGC or AIS indicates endometrial neoplasia in women 50 years or older and pre-cancerous or invasive glandular cervical lesions in younger women. HPV testing seems to identify underlying cervical adenocarcinoma and high grade squamous intraepithelial lesions.
authors: Department of Obstetrics and Gynaecology, Skane University Hospital, Lund, Sweden christine.asciutto@yahoo.com.
authors: Katrin Christine
authors: KC
authors: Asciutto
authors: Department of Obstetrics and Gynaecology, Skane University Hospital, Lund, Sweden.
authors: Emir
authors: E
authors: Henic
authors: Department of Clinical Virology, Skane University Hospital, Lund, Sweden.
authors: Ola
authors: O
authors: Forslund
authors: Regional Cancer Centre South, Skane University Hospital, Lund, Sweden.
authors: Kaj
authors: K
authors: Bjelkenkrantz
authors: Department of Obstetrics and Gynaecology, Skane University Hospital, Lund, Sweden.
authors: Christer
authors: C
authors: Borgfeldt
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000821:virology; D000367:Age Factors; D052685:Alphapapillomavirus / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology
keywords: Cervical cancer; Pap smear; adenocarcinoma in situ; atypical glandular cells; clinical population study