title: Photochemical reactions of microcrystalline thymidine.
abstract: Nucleoside/nucleotide/oligonucleotide photoreactions usually result in a number of products simultaneously due to a wide range of conformers existing at a given time. Such a complicated reaction pattern makes it difficult for one to focus on a single DNA photoproduct and elucidate the requirements for its formation. A rare example of thymidine photoreaction in microcrystals is reported, where 5-thyminyl-5,6-dihydrothymine, e.g., the spore photoproduct (SP), is produced as the dominant species in ∼85% yield. This unprecedented high yield clears the major obstacle for future SP photochemistry studies in detail.
authors: Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI) , 402 North Blackford Street, Indianapolis, Indiana 46202, United States.
authors: Yajun
authors: Y
authors: Jian
authors: David M
authors: DM
authors: Ames
authors: Hao
authors: H
authors: Ouyang
authors: Lei
authors: L
authors: Li
mesh_terms: D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D010777:Photochemistry; D013936:Thymidine / Q000737:chemistry*; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D009841:Oligonucleotides; C009484:5-thyminyl-5,6-dihydrothymine; D004247:DNA; D013941:Thymine; D013936:Thymidine