title: Risk of Colorectal and Other Cancers in Patients With Serrated Polyposis.
abstract: Patients with serrated polyposis develop multiple colorectal hyperplastic and/or serrated sessile adenomas/polyps. We investigated the risk of colorectal and other cancers by analyzing data from 64 patients with serrated polyposis (mean age at diagnosis, 54 y; 41% men; 92% white) listed in the Johns Hopkins Polyposis Registry. Medical, endoscopic, and histopathology reports were evaluated. Six patients (9.4%) had a history of colorectal cancer, diagnosed at a mean age of 56 years; 6 additional patients (9.4%) had at least 1 advanced colorectal adenoma. Extracolonic cancers were found in 16% of the study population. The standard incidence ratio for colorectal cancer in patients with serrated polyposis was 18.72 (95% confidence interval, 6.87-40.74) and for extracolonic cancer was 31.20 (95% confidence interval, 14.96-57.37), compared with the Surveillance, Epidemiology, and End Results population. Patients with serrated polyposis therefore have a high risk for colorectal cancer and require vigilant colorectal surveillance, starting at the time of diagnosis of serrated polyposis. The risk of extracolonic cancer also appears to be increased, but this requires further evaluation.
authors: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Daniel L
authors: DL
authors: Edelstein
authors: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, University of Puerto Rico/MD Anderson Cancer Center Partnership for Excellence in Cancer Research, San Juan, Puerto Rico.
authors: Marcia
authors: M
authors: Cruz-Correa
authors: School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
authors: Marievelisse
authors: M
authors: Soto-Salgado
authors: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Jennifer E
authors: JE
authors: Axilbund
authors: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Linda M
authors: LM
authors: Hylind
authors: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Katharine
authors: K
authors: Romans
authors: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Cherie
authors: C
authors: Blair
authors: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Elizabeth
authors: E
authors: Wiley
authors: Utrecht Medical Center, Utrecht, The Netherlands.
authors: Anne C
authors: AC
authors: Tersmette
authors: Utrecht Medical Center, Utrecht, The Netherlands.
authors: Johan A
authors: JA
authors: Offerhaus
authors: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: edelstein@jhu.edu.
authors: Francis M
authors: FM
authors: Giardiello
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003111:Colonic Polyps / Q000150:complications*; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D055815:Young Adult
keywords: Colon Cancer; Hyperplastic Polyps; Premalignant; Sessile Polyps