title: Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes.
abstract: BACKGROUND
  Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5.
  
  
  RESULTS
  The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (p for trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation with Apo- A1(r=0.22, p=0.02).
  
  
  CONCLUSIONS
  This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM.
authors: 1. PhD. Professor of Nutrition, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. shidfar.f@iums.ac.ir.
authors: Farzad
authors: F
authors: Shidfar
authors: 2. PhD, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. zarrati_ms@yahoo.com.
authors: Mitra
authors: M
authors: Zarrati
authors: 3. Professor of Endocrinology, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. khamseh.m@iums.ac.ir.
authors: Mohamad Ebrahim
authors: ME
authors: Khamseh
authors: 4. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. neda.hag@gmail.com.
authors: Neda
authors: N
authors: Haghighat
authors: 5. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. ali.rostami.nut@gmail.com.
authors: Ali
authors: A
authors: Rostami
authors: 6. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. h.z.7025@gmail.com.
authors: Hamid
authors: H
authors: Zolfaghari
keywords: Apo-A1; Apo-B100; Body Fat Percentage; Fetuin-A; Insulin Resistance; Type 2 Diabetes