title: Sub-diffuse interstitial optical tomography to improve the safety of brain needle biopsies: a proof-of-concept study.
abstract: The extraction of tissue samples during brain needle biopsy can cause life-threatening hemorrhage because of significant blood vessel injury during the procedure. Vessel rupture can have significant consequences for patient health, ranging from transient neurological deficits to death. Here, we present a sub-diffuse optical tomography technique that can be integrated into neurosurgical workflow to detect the presence of blood vessels. A proof-of-concept study performed on a realistic brain tissue phantom is presented and demonstrates that interstitial optical tomography (iOT) can detect several 1 mm diameter high-contrast absorbing objects located <2  mm from the needle.
authors: Andréanne
authors: A
authors: Goyette
authors: Julien
authors: J
authors: Pichette
authors: Marie-Andrée
authors: MA
authors: Tremblay
authors: Audrey
authors: A
authors: Laurence
authors: Michael
authors: M
authors: Jermyn
authors: Kelvin
authors: K
authors: Mok
authors: Keith D
authors: KD
authors: Paulsen
authors: David W
authors: DW
authors: Roberts
authors: Kevin
authors: K
authors: Petrecca
authors: Brian C
authors: BC
authors: Wilson
authors: Frédéric
authors: F
authors: Leblond
mesh_terms: D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D019047:Phantoms, Imaging; D012449:Safety; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000379:methods*; D041622:Tomography, Optical