title: Ebola virus disease in mice with transplanted human hematopoietic stem cells.
abstract: The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Anja
authors: A
authors: Lüdtke
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Lisa
authors: L
authors: Oestereich
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Paula
authors: P
authors: Ruibal
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Stephanie
authors: S
authors: Wurr
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Elisa
authors: E
authors: Pallasch
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Sabrina
authors: S
authors: Bockholt
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors: Wing Hang
authors: WH
authors: Ip
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Toni
authors: T
authors: Rieger
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors: Sergio
authors: S
authors: Gómez-Medina
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors: Carol
authors: C
authors: Stocking
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors: Estefanía
authors: E
authors: Rodríguez
authors: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
authors: Stephan
authors: S
authors: Günther
authors: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany cesar.munoz-fontela@hpi.uni-hamburg.de.
authors: César
authors: C
authors: Muñoz-Fontela
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000276:immunology*; D005234:Fatty Liver / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006470:Hemorrhage / Q000473:pathology; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology* / Q000473:pathology / Q000635:transmission*; D064593:Heterografts / Q000276:immunology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D051379:Mice; D016688:Mice, Inbred NOD; D008856:Microscopy, Fluorescence; D014766:Viremia / Q000473:pathology