title: Can the irradiated brain be salvaged by oligodendrocyte precursor transplantation?
abstract: Radiotherapy is a mainstay of brain cancer treatment, but it causes significant complications. In this issue of Cell Stem Cell, Piao et al. (2015) derive oligodendrocyte precursors from human embryonic stem cells and show that engrafted cells replenish depleted precursor numbers, generate new myelin, and reverse behavioral defects in irradiated rats.
authors: MRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors: Marie C
authors: MC
authors: Harrisingh
authors: MRC Centre for Regenerative Medicine, University of Edinburgh, SCRM Building, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK. Electronic address: cffc@ed.ac.uk.
authors: Charles
authors: C
authors: ffrench-Constant
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000528:radiation effects*; D003072:Cognition Disorders / Q000209:etiology* / Q000628:therapy*; D005260:Female; D000066449:Human Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology*