title: Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.
abstract: Uric acid (UA) is reduced in multiple sclerosis (MS), and possibly relates to MS outcomes, with lower UA levels in subjects experiencing a relapse or presenting higher disability scores. The present retrospective longitudinal study evaluated UA variations in MS, in relation to clinical relapses, disability progression, and cognitive functions. We included 141 subjects with relapsing-remitting MS (RRMS) and performed expanded disability status scale (EDSS), symbol digit modalities test (SDMT) and UA evaluation at baseline visit and after 2-year follow-up. Paired t test showed significantly lower UA levels after 2-year follow-up than at baseline (3.987 ± 1.135 and 4.167 ± 1.207 mg/dL, respectively) (p = 0.001). The difference in UA levels between 2-year follow-up and baseline related to EDSS sustained progression (p < 0.001; OR = 0.099), and presented a trend for clinical relapses at logistic regression (p = 0.211; OR = 0.711) and for the time to relapse at Cox regression (p = 0.236; HR = 0.792). Analysis of variance showed reduced baseline UA levels in subjects with impaired SDMT at baseline (p = 0.045; adjusted R(2) = 0.473) and after 2-year follow-up (p = 0.034; adjusted R(2) = 0.470). This is the first study showing a progressive reduction of UA levels during the course of RRMS, suggesting a progressive decrease of antioxidant reserves, in relation to relapse risk, disability progression and cognitive function.
authors: Department of Neurosciences, Reproductive Sciences and Odontostomatology, Multiple Sclerosis Centre, Federico II University, Naples, Italy.
authors: Marcello
authors: M
authors: Moccia
authors: Roberta
authors: R
authors: Lanzillo
authors: Teresa
authors: T
authors: Costabile
authors: Cinzia
authors: C
authors: Russo
authors: Antonio
authors: A
authors: Carotenuto
authors: Gabriella
authors: G
authors: Sasso
authors: Emanuela
authors: E
authors: Postiglione
authors: Carla
authors: C
authors: De Luca Picione
authors: Michele
authors: M
authors: Vastola
authors: Giorgia Teresa
authors: GT
authors: Maniscalco
authors: Raffaele
authors: R
authors: Palladino
authors: Vincenzo
authors: V
authors: Brescia Morra
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000378:metabolism*; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D014527:Uric Acid / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014527:Uric Acid