title: New application of carbon nanotubes in haemostatic dressing filled with anticancer substance.
abstract: The drug-carrier system used as innovative haemostatic dressing with oncostatic action is studied. It is obtained from CDDP (cisplatin) doped SWCNT (single walled carbon nanotubes), modified and purified by H2O2 in hydrothermal treatment process. In the in vivo nephron sparing surgery (NSS) study we used 35 BALB/c nude mice with induced renal cancer using adenocarcinoma 786-o cells. Animals were divided into four groups: CDDP(M-), CDDP(M+), CONTROL(M-) and CONTROL(M+). In CDDP(M-) and CDDP(M+) groups we used, intraoperatively, carbon nanotubes filled with cisplatin (CDDP). In CONTROL(M-) and CONTROL(M+) groups carbon nanotubes were used alone. During NSS free margin (M-) or positive margin (M+) was performed. In the CDDP(M-) group, we do not observe local tumor recurrences. In Group CDDP(M+) only one animal was diagnosed with tumor recurrence. In control groups the recurrent tumor formation was observed. In our study, it is shown that CDDP filled SWCNT inhibit cancer recurrence in animal model NSS study, and can be successfully applied as haemostatic dressings for local chemoprevention.
authors: N. Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St. 24, 85-092 Bydgoszcz, Poland.
authors: M
authors: M
authors: Nowacki
authors: N. Copernicus University, Department of Chemistry, Physicochemistry of Carbon Materials Research Group, Gagarin St. 7, 87-100 Toruń, Poland.
authors: M
authors: M
authors: Wiśniewski
authors: N. Copernicus University, Department of Chemistry, Physicochemistry of Carbon Materials Research Group, Gagarin St. 7, 87-100 Toruń, Poland.
authors: K
authors: K
authors: Werengowska-Ciećwierz
authors: N. Copernicus University, Department of Chemistry, Physicochemistry of Carbon Materials Research Group, Gagarin St. 7, 87-100 Toruń, Poland. Electronic address: aterzyk@chem.umk.pl.
authors: A P
authors: AP
authors: Terzyk
authors: N. Copernicus University, Department of Clinical Pathomorphology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Jagiellońska 13-15, 85-067 Bydgoszcz, Poland.
authors: T
authors: T
authors: Kloskowski
authors: Medical University of Warsaw, Department of General, Transplant and Liver Surgery, Banacha 1a, 02-097 Warsaw, Poland.
authors: A
authors: A
authors: Marszałek
authors: Medical University of Warsaw, Department of General, Transplant and Liver Surgery, Banacha 1a, 02-097 Warsaw, Poland.
authors: M
authors: M
authors: Bodnar
authors: N. Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St. 24, 85-092 Bydgoszcz, Poland.
authors: M
authors: M
authors: Pokrywczyńska
authors: N. Copernicus Hospital, Urology and Oncological Urology Department, Batorego St. 17/19, 87-100 Toruń, Poland.
authors: Ł
authors: Ł
authors: Nazarewski
authors: N. Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St. 24, 85-092 Bydgoszcz, Poland.
authors: K
authors: K
authors: Pietkun
authors: N. Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St. 24, 85-092 Bydgoszcz, Poland.
authors: A
authors: A
authors: Jundziłł
authors: N. Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St. 24, 85-092 Bydgoszcz, Poland; N. Copernicus Hospital, Urology and Oncological Urology Department, Batorego St. 17/19, 87-100 Toruń, Poland.
authors: T
authors: T
authors: Drewa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001458:Bandages; D002292:Carcinoma, Renal Cell / Q000473:pathology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D006490:Hemostatics / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D006490:Hemostatics; D037742:Nanotubes, Carbon; D002945:Cisplatin
keywords: Anticancer therapy; Carbon nanotubes; Dressings; Drug delivery