title: Epigenetics in idiopathic pulmonary fibrosis.
abstract: Idiopathic pulmonary fibrosis (IPF) is a lethal chronic lung disorder with no effective treatment and a prognosis worse than that of lung cancer. Despite extensive research efforts, its etiology and pathogenesis still remain largely unknown. Current experimental evidence has shifted the disease paradigm from chronic inflammation towards the premise of abnormal epithelial wound repair in response to repeated epigenetic injurious stimuli in genetically predisposed individuals. Epigenetics is defined as the study of heritable changes in gene function by factors other than an individual's DNA sequence, providing valuable information regarding adaption of genes to environmental changes. Although cancer is the most studied disease with relevance to epigenetic modifications, recent data support the idea that epigenomic alterations may lead to variable disease phenotypes, including fibroproliferative lung disorders such as IPF. This review article summarizes the latest experimental and translational epigenetic studies in the research field of chronic lung disorders, mainly focusing on IPF, highlights current methodology limitations, and underlines future directions and perspectives.
authors: Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, 300 Cedar St., TAC-441 South, P.O. Box 208057, New Haven, CT 06520, USA.
authors: Argyrios
authors: A
authors: Tzouvelekis
authors: Naftali
authors: N
authors: Kaminski
mesh_terms: D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000235:genetics*; D008171:Lung Diseases / Q000235:genetics; D051379:Mice; D062085:RNA, Long Noncoding / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding
keywords: ARN non codant; DNA methylation; epigenetic treatments; fibroproliferative disorders; histone modification; maladie fibro-proliférative; modification des histones; méthylation d’ADN; noncoding RNAs; traitements épigénétiques