title: SIRT1 synchs satellite cell metabolism with stem cell fate.
abstract: Metabolic reprogramming of muscle stem cells modulates myogenic cell fate. In this issue of Cell Stem Cell, Ryall et al. (2015) show that SIRT1, a NAD(+)-dependent histone deacetylase, acts as an epigenetic regulator that connects changes in satellite cell metabolism with changes in the transcriptional machinery toward myogenic commitment.
authors: Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors: Alberto
authors: A
authors: Diaz-Ruiz
authors: Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors: Marta
authors: M
authors: Gonzalez-Freire
authors: Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors: Luigi
authors: L
authors: Ferrucci
authors: Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
authors: Michel
authors: M
authors: Bernier
authors: Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: deCaboRa@mail.nih.gov.
authors: Rafael
authors: R
authors: de Cabo
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D018482:Muscle, Skeletal / Q000166:cytology* / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*
chemical_list: D009243:NAD; D056564:Sirtuin 1