title: The multifaceted role of CD146/MCAM in the promotion of melanoma progression.
abstract: Human malignant melanoma is a common primary malignant cutaneous tumour derived from transformed epidermal melanocytes. Patients with melanoma have a high rate of mortality due to resistance to chemotherapeutic drugs, a major obstacle to a successful treatment. Several reports have suggested that CD146 plays an important role as a signalling molecule in human melanoma. This role includes CD146 as a participant in inflammation, differentiation, adhesion, tumourigenicity, metastasis, invasion and angiogenesis among other processes, which suggests that this molecule promotes the progression of human melanoma as a multifaceted regulator. In this article, we explore the effects and corresponding mechanisms with respect to the role of CD146/MUC18 in the promotion of human melanoma progression. Collectively, the studies indicated that targeting CD146, because it is a suitable marker of poor patient outcome, might be useful in the design of future strategies for the prevention and treatment of human melanoma.
authors: Department of Orthopedic Surgery, Linyi People's Hospital, Linyi, 276000 China.
authors: Xing
authors: X
authors: Lei
authors: Department of Orthopedic Surgery, the First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001 China.
authors: Ce-Wen
authors: CW
authors: Guan
authors: Department of Orthopedic Surgery, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150001 China.
authors: Yang
authors: Y
authors: Song
authors: Department of Orthopedic Surgery, the First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001 China.
authors: Huan
authors: H
authors: Wang
keywords: Angiogenesis; CD146/MCAM; Mechanism; Melanoma; Metastasis; Structure