title: [Comparative study of the titanium and titanium alloy implant electrolytic etching surface].
abstract: OBJECTIVE
  This preliminary study aims to investigate the effects of titanium and titanium alloy micro-nano-dimensional topography on the biological behavior of osteoblasts in vitro.
  
  
  METHODS
  Electrolytic etching (EE) method was used to produce micro-nano dimensional titanium surfaces. The surfaces were observed to determine their effects on the adhesion, proliferation, cell morphology, and alkaline phosphatase (ALP) activity of osteoblasts.
  
  
  RESULTS
  The surfaces of the titanium and titanium alloy groups exhibited higher adhesion and proliferation of osteoblasts than those of the mechanical group. The titanium surface was covered with a group of cells, a large number of filopodia, and functional particles. The ALP activity of the titanium group was significantly higher than that of the titanium alloy and mechanical groups.
  
  
  CONCLUSIONS
  EE method in pure titanium and titanium alloy surfaces result in bowl-like nests and nanostructures of different diameters and depths. The diameters of the pure titanium and titanium alloy surfaces range from 30 to 50 μm and 5 to 8 μm, respectively. The former is more conducive to promote the proliferation and differentiation of cells.
authors: Wang
authors: W
authors: Shizhen
authors: Meng
authors: M
authors: Wei-Yan
authors: Jiao
authors: J
authors: Guotian
authors: Zhang
authors: Z
authors: Bin
authors: Li
authors: L
authors: Baosheng
authors: Dou
authors: D
authors: Linbo
authors: Niu
authors: N
authors: Jincheng
authors: Cai
authors: C
authors: Qing
mesh_terms: D000497:Alloys; D002454:Cell Differentiation; D049109:Cell Proliferation; D045662:Dental Etching; D006801:Humans; D049329:Nanostructures; D010006:Osteoblasts; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium
chemical_list: D000497:Alloys; D014025:Titanium