title: Complications of new medications.
abstract: Numerous mandibular pathologies are diagnosed in the emergency department (ED). We present the case of a woman with severe right-sided mandibular pain who was found to have a pathological fracture and osteonecrosis of the jaw (ONJ). The etiology of ONJ was found to be associated to previous use of zoledronic acid to treat osteoporosis. The aim of this case report is to discuss the etiology, diagnosis and treatment of ONJ secondary to the use of zoledronic acid and to outline a clinical condition rarely seen in the ED whose incidence might rise with the increasing use of bisphosphonates.
authors: The University of Texas Health Science Center at Houston, Department of Emergency Medicine, Houston, Texas.
authors: Carlos J
authors: CJ
authors: Roldan
authors: The University of Texas Health Science Center at Houston, Department of Emergency Medicine, Houston, Texas.
authors: Linda
authors: L
authors: Paniagua
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis / Q000209:etiology*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008337:Mandibular Fractures / Q000175:diagnosis / Q000209:etiology*; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid