title: Incidence and clinical impact of infective endocarditis after transcatheter aortic valve implantation.
abstract: OBJECTIVE
  To describe the characteristics of infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI).
  
  
  RESULTS
  This study was performed using the GAMES database, a national prospective registry of consecutive patients with IE in 26 Spanish hospitals. Of the 739 cases of IE diagnosed during the study, 1.3% were post-TAVI IE, and these 10 cases, contributed by five centres, represented 1.1% of the 952 TAVIs performed. Mean age was 80 years. All valves were implanted transfemorally. IE appeared a median of 139 days after implantation. The mean age-adjusted Charlson comorbidity index was 5.45. Chronic kidney disease was frequent (five patients), as were atrial fibrillation (five patients), chronic obstructive pulmonary disease (four patients), and ischaemic heart disease (four patients). Six patients presented aortic valve involvement, and four only mitral valve involvement; the latter group had a higher percentage of prosthetic mitral valves (0% vs. 50%). Vegetations were found in seven cases, and four presented embolism. One patient underwent surgery. Five patients died during follow-up: two of these patients died during the admission in which the valve was implanted.
  
  
  CONCLUSIONS
  IE is a rare but severe complication after TAVI which affects about 1% of patients and entails a relatively high mortality rate. IE occurred during the first year in nine of the 10 patients.
authors: Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Manuel
authors: M
authors: Martínez-Sellés
authors: Emilio
authors: E
authors: Bouza
authors: Pablo
authors: P
authors: Díez-Villanueva
authors: Maricela
authors: M
authors: Valerio
authors: María Carmen
authors: MC
authors: Fariñas
authors: Antonio J
authors: AJ
authors: Muñoz-García
authors: Josefa
authors: J
authors: Ruiz-Morales
authors: Juan
authors: J
authors: Gálvez-Acebal
authors: Isabel
authors: I
authors: Antorrena
authors: Jesús María
authors: JM
authors: de la Hera Galarza
authors: Enrique
authors: E
authors: Navas
authors: Patricia
authors: P
authors: Muñoz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000601:surgery*; D004696:Endocarditis / Q000628:therapy*; D004697:Endocarditis, Bacterial / Q000453:epidemiology*; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D016459:Prosthesis-Related Infections / Q000453:epidemiology*; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects; D016896:Treatment Outcome