title: Antimicrobial activity of secondary metabolites from Streptomyces sp. K15, an endophyte in Houttuynia cordata Thunb.
abstract: We isolated Streptomyces sp. K15 from the root tissue of Houttuynia cordata Thunb and found that some of its secondary metabolites exhibited significant antimicrobial activity against Botrytis cinerea. Moreover, we separated, purified and identified the major active ingredient to be 2-pyrrol formic acid by using silica gel column chromatography, high-performance liquid chromatography and NMR analysis of the spectral data. 2-Pyrrol formic acid critically inhibited the growth of some phytopathogenic bacteria. Therefore, it has potential value in agricultural applications.
authors: a College of Life Science; Sichuan University , Chengdu 610064 , P.R. China.
authors: Huabao
authors: H
authors: Chen
authors: b College of Agronomy, Sichuan Agricultural University , Wenjiang District, Chengdu 611130 , P.R. China.
authors: Chunping
authors: C
authors: Yang
authors: a College of Life Science; Sichuan University , Chengdu 610064 , P.R. China.
authors: Tao
authors: T
authors: Ke
authors: b College of Agronomy, Sichuan Agricultural University , Wenjiang District, Chengdu 611130 , P.R. China.
authors: Miaomiao
authors: M
authors: Zhou
authors: b College of Agronomy, Sichuan Agricultural University , Wenjiang District, Chengdu 611130 , P.R. China.
authors: Zhaojun
authors: Z
authors: Li
authors: b College of Agronomy, Sichuan Agricultural University , Wenjiang District, Chengdu 611130 , P.R. China.
authors: Min
authors: M
authors: Zhang
authors: b College of Agronomy, Sichuan Agricultural University , Wenjiang District, Chengdu 611130 , P.R. China.
authors: Guoshu
authors: G
authors: Gong
authors: a College of Life Science; Sichuan University , Chengdu 610064 , P.R. China.
authors: Taiping
authors: T
authors: Hou
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D060026:Endophytes / Q000737:chemistry; D005561:Formates / Q000737:chemistry* / Q000302:isolation & purification; D052859:Houttuynia / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification
chemical_list: C000603975:2-pyrrol formic acid; D000890:Anti-Infective Agents; D005561:Formates; D011758:Pyrroles; C030544:formic acid
keywords: 2-pyrrol formic acid; Streptomyces albolongus; antimicrobial activity; endophyte; secondary metabolites