title: HSV cheats the executioner.
abstract: In this issue of Cell Host & Microbe, Huang et al. (2015) and Guo et al. (2015), along with recent work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in either inducing or preventing necroptosis, depending on the host species. This evolutionary twist underscores the importance of selective pressure in virus-host relationships.
authors: Departments of Biochemistry and Biomedical Sciences and Pathology and Molecular Medicine, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
authors: Karen L
authors: KL
authors: Mossman
authors: Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: weller@uchc.edu.
authors: Sandra K
authors: SK
authors: Weller
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D008297:Male; D011494:Protein Kinases / Q000378:metabolism*; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins; D011494:Protein Kinases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases