title: Serum cytokine and chemokine profiles in patients with chronic inflammatory demyelinating polyneuropathy.
abstract: To identify serum cytokine networks specific to chronic inflammatory demyelinating polyneuropathy (CIDP), serum samples of two subgroups (18 patients with typical CIDP and 12 patients with multifocal acquired demyelinating sensory and motor neuropathy [MADSAM]) were analyzed with multiplex magnetic bead-based cytokine assay. TNF-α, HGF, MIP-1β and IL-1β levels were significantly higher in total CIDP patients than in normal controls. Of these, HGF levels were elevated in typical CIDP patients, but not in MADSAM patients. Patients with high HGF levels showed good responses to steroid treatment. Different cytokine profiles among the CIDP subtypes presumably reflect differences in pathophysiology.
authors: Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. Electronic address: beppu@chiba-u.jp.
authors: Minako
authors: M
authors: Beppu
authors: Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Setsu
authors: S
authors: Sawai
authors: Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Sonoko
authors: S
authors: Misawa
authors: Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Kazuyuki
authors: K
authors: Sogawa
authors: Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Masahiro
authors: M
authors: Mori
authors: Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Takayuki
authors: T
authors: Ishige
authors: Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Mamoru
authors: M
authors: Satoh
authors: Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Fumio
authors: F
authors: Nomura
authors: Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
authors: Satoshi
authors: S
authors: Kuwabara
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood* / Q000145:classification; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood*
chemical_list: D016207:Cytokines
keywords: Chronic inflammatory demyelinating polyneuropathy; Cytokine; HGF; IL-1β; MIP-1α; MIP-1β; TNF-α