title: Biocatalysts for the formation of three- to six-membered carbo- and heterocycles.
abstract: During the last decade, the number of different types of enzymes applicable for organic synthesis as biocatalysts has significantly increased. Consequently, the spectrum of reactions has significantly expanded also for cyclisations. This review highlights heterologously expressable biocatalysts transforming non-natural substrates for the formation of three- to six-membered carbo- and heterocycles, excluding terpene cyclases as well as SAM-dependent enzymes. The review focuses on the non-natural substrate scope and the mechanism of the selected enzymes.
authors: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors: Horst
authors: H
authors: Lechner
authors: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors: Desiree
authors: D
authors: Pressnitz
authors: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria. Electronic address: wolfgang.kroutil@uni-graz.at.
authors: Wolfgang
authors: W
authors: Kroutil
mesh_terms: D055162:Biocatalysis; D001709:Biotechnology; D004798:Enzymes; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000378:metabolism
chemical_list: D004798:Enzymes; D006571:Heterocyclic Compounds
keywords: Biocatalysis; Carbocycles; Cyclisation; Enzymes; Heterocycles; Non-natural substrates; Three–six membered rings