title: Anatomical patterns of dermatitis in adult filaggrin mutation carriers.
abstract: BACKGROUND
  Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population.
  
  
  OBJECTIVE
  We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype.
  
  
  METHODS
  Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years. Information about dermatitis on the hands; feet; face; axillae; and abdomen, chest, or back was obtained by use of questionnaires. Participants were genotyped for common FLG mutations. A history of AD was defined by the United Kingdom Working Party's diagnostic criteria.
  
  
  RESULTS
  The frequency of foot dermatitis in the general population was associated with FLG genotype (P = .014). However, when stratification of FLG genotype and AD was performed, we found that FLG mutations increased the prevalence (odds ratios) of foot dermatitis (odds ratio 10.41; 95% confidence interval 5.27-20.60) and persistent hand dermatitis (odds ratio 17.57; 95% confidence interval 8.60-35.89) only in participants with AD.
  
  
  CONCLUSIONS
  Potential misclassification and recall bias are study limitations.
  
  
  CONCLUSIONS
  FLG mutations affected the lifetime prevalence of hand and foot dermatitis in participants with a history of AD.
authors: National Allergy Research Center, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Hellerup, Denmark. Electronic address: nina.glasser.heede@regionh.dk.
authors: Nina G
authors: NG
authors: Heede
authors: National Allergy Research Center, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
authors: Jacob P
authors: JP
authors: Thyssen
authors: Research Center for Prevention and Health, the Capital Region of Denmark, Glostrup, Denmark.
authors: Betina H
authors: BH
authors: Thuesen
authors: Research Center for Prevention and Health, the Capital Region of Denmark, Glostrup, Denmark; Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: Allan
authors: A
authors: Linneberg
authors: National Allergy Research Center, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
authors: Jeanne D
authors: JD
authors: Johansen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000473:pathology*; D005260:Female; D000091344:Filaggrin Proteins; D005838:Genotype; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D055815:Young Adult
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: atopic dermatitis; epidemiology; filaggrin; foot dermatitis; genotype; hand dermatitis; population study