title: New antifungal and antiviral dosing.
abstract: Neonatal fungal and viral infections are associated with mortality and neurologic impairment among survivors. Advances in pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial medications have led to improved dosing guidance for neonates. This article discusses the basic PK/PD properties and dosing of the most common antifungal and antiviral medications used in neonates.
authors: Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, Children's Hospital of Philadelphia Newborn Care at Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA. Electronic address: kelly.wade@uphs.upenn.edu.
authors: Kelly C
authors: KC
authors: Wade
authors: Department of Pharmacy, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19107, USA.
authors: Heather M
authors: HM
authors: Monk
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000493:pharmacokinetics; D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D058365:Candidiasis, Invasive / Q000188:drug therapy*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D003840:Deoxycholic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D004338:Drug Combinations; D015725:Fluconazole / Q000008:administration & dosage / Q000493:pharmacokinetics; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009181:Mycoses / Q000188:drug therapy; D017410:Practice Guidelines as Topic; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D000077562:Valganciclovir; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D015725:Fluconazole; D000077562:Valganciclovir; D015774:Ganciclovir; D000212:Acyclovir
keywords: Acyclovir; Amphotericin; Echinocandin; Fluconazole; Ganciclovir; Neonate