title: ARVCF expression is significantly correlated with the malignant phenotype of non-small cell lung cancer.
abstract: Armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) is a member of the p120 catenin (p120ctn) family; it contains nine central Armadillo repeats and binds to the juxtamembrane domain of E-cadherin. We used immunohistochemistry to measure ARVCF expression in 121 patients with NSCLC and western blotting to examine differences in ARVCF expression between lung cancer and adjacent normal lung tissues. We interfered with ARVCF expression in two lung cancer cell lines and measured its effects on invasion and proliferation. ARVCF expression correlated with the malignant phenotype and poor prognosis. We also observed ARVCF-dependent changes in small GTPase (mainly RhoA) activity in lung cancer cells. We confirmed that ARVCF plays an important role in the malignant phenotype.
authors: The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
authors: Di
authors: D
authors: Zhang
authors: The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
authors: Na
authors: N
authors: Tang
authors: The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
authors: Yang
authors: Y
authors: Liu
authors: The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
authors: En-Hua
authors: EH
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051186:Armadillo Domain Proteins / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010750:Phosphoproteins / Q000378:metabolism*
chemical_list: C411307:ARVCF protein, human; D051186:Armadillo Domain Proteins; D015815:Cell Adhesion Molecules; D010750:Phosphoproteins
keywords: ARVCF; NSCLC; RhoA; invasion; p120ctn