title: Liposomes as siRNA delivery vectors.
abstract: Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized.
authors: Sabrina
authors: S
authors: Bochicchio
authors: Annalisa
authors: A
authors: Dalmoro
authors: Anna Angela
authors: AA
authors: Barba
authors: Gabriele
authors: G
authors: Grassi
authors: Dipartimento di Farmacia, Universita degli Studi di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA) - Italy. aabarba@unisa.it.
authors: Gaetano
authors: G
authors: Lamberti
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D006801:Humans; D008081:Liposomes; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D008081:Liposomes; D034741:RNA, Small Interfering