title: Noncoding RNAs as regulators of cardiomyocyte proliferation and death.
abstract: Cardiovascular diseases are currently the main cause of morbidity and mortality worldwide. Ischemic heart disease, in particular, is responsible for the majority of cardiac-related deaths. Given the negligible regenerative potential of the human myocardium, there is a strong need for therapeutic strategies aiming at enhancing cardiomyocyte survival and proliferation following injury or at inhibiting their death. MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression at a post-transcriptional level with important functions in cardiovascular physiology and disease. It has been demonstrated that miRNAs can influence the ability of cardiomyocytes to enter the cell cycle and/or escape from death pathways. Additionally, long non coding-RNAs could be involved in such pathways. This review summarizes recent evidences on noncoding RNAs regulating proliferation and death of cardiomyocytes representing a future therapeutic for the treatment of heart diseases. This article is part of a Special Issue entitled SI: Non-coding RNAs.
authors: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany.
authors: Maria-Teresa
authors: MT
authors: Piccoli
authors: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany.
authors: Shashi Kumar
authors: SK
authors: Gupta
authors: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, UK. Electronic address: Thum.Thomas@mh-hannover.de.
authors: Thomas
authors: T
authors: Thum
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics; D016923:Cell Death / Q000235:genetics; D049109:Cell Proliferation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: Apoptosis; Autophagy; Cardiomyocyte; MicroRNAs; Necrosis; Proliferation