title: Variation in C-reactive protein following weight loss in obese insulin resistant postmenopausal women: is there an independent contribution of lean body mass?
abstract: BACKGROUND
  We showed that obese insulin resistant postmenopausal women are characterized by higher lean body mass and elevated C-reactive protein. Although counterintuitive, we hypothesized that losses in muscle mass following caloric restriction and increase in muscle quality will be associated with improvements in glucose homeostasis through decreases in C-reactive protein.
  
  
  OBJECTIVE
  To determine 1) if improvements in C-reactive protein concentrations occurs through losses in lean body mass; and 2) if decreases in C-reactive protein levels contribute to improvements in insulin sensitivity.
  
  
  METHODS
  50 postmenopausal women (body mass index>26 kg/m(²)) with impaired glucose disposal (<7.5 mg/kg/min) completed a 6-month caloric restriction program. Outcome measures were: Glucose disposal rate: M value (by hyperinsulinemic-euglycemic clamp), body composition (total, trunk, and appendicluar). LBM and FM by DXA), LBM index (LBM (kg)/height (m(2)), body fat distribution (VAT and SAT by CT scan) and plasma high-sensitive C-reactive protein (hsCRP) and interleukin-6 (Il-6).
  
  
  RESULTS
  Significant correlations were observed between Δ hsCRP levels with Δ Il-6 (r=0.33, p≤0.05), Δ total LBM index (r=0.44, p≤0.01), Δ trunk LBM (r=0.38, p≤0.01) Δ SAT (r=0.35, p≤0.05) and ∆ glucose disposal rate (r=- 0.44, p≤0.01). After including all the correlated variables in Stepwise linear regression model, Δ LBM index was the only independent predictor of the reduction in hsCRP levels (R(2)=0.20, p≤0.01).
  
  
  CONCLUSIONS
  Losses in total lean body mass are independently associated with improvements in inflammatory state (CRP levels) in obese postmenopausal women with impaired glucose disposal.
authors: Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: R
authors: R
authors: Barsalani
authors: Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: É
authors: É
authors: Riesco
authors: Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: K
authors: K
authors: Perreault
authors: Behavioral and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
authors: P
authors: P
authors: Imbeault
authors: Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: M
authors: M
authors: Brochu
authors: Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, Quebec, Canada.
authors: I J
authors: IJ
authors: Dionne
mesh_terms: D000368:Aged; D001823:Body Composition / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism*; D031204:Caloric Restriction; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D009765:Obesity / Q000276:immunology / Q000378:metabolism*; D017698:Postmenopause / Q000276:immunology / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D002097:C-Reactive Protein