title: Effects of buprenorphine on balance of oxidant/antioxidant system in the different ages of male rat liver.
abstract: Our knowledge about a link between buprenorphine and hepatotoxicity is controversial. This study evaluated the effects of buprenorphine on the liver of young, adult, and aged rats. For this reason, young, adult, and aged rats received intraperitoneally 0.25, 0.5, and 1 mg/kg buprenorphine for 30 days. The present results revealed that the normal aging was associated with a significant decrease in the activities of antioxidant enzymes, and an increase in the liver lipid peroxidation, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities in the aged rats. This study also demonstrated that buprenorphine led to a significant increase in the serum activities of ALT, AST, and LDH as well as liver lipid peroxidation content with a decrease in the antioxidant enzymes in the liver of buprenorphine-treated aged rat versus the aged matched control animals. In conclusion, the present results demonstrate that buprenorphine deteriorated oxidative damage in the aged livers.
authors: Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. samarghandians@mums.ac.ir.
authors: Saeed
authors: S
authors: Samarghandian
authors: Department of Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Mohsen
authors: M
authors: Azimi-Nezhad
authors: Addiction Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Reza
authors: R
authors: Afshari
authors: Addiction Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Tahereh
authors: T
authors: Farkhondeh
authors: Department of Food Hygiene, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Fatemeh
authors: F
authors: Karimnezhad
mesh_terms: D000375:Aging / Q000378:metabolism*; D000410:Alanine Transaminase / Q000097:blood; D000701:Analgesics, Opioid / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D002047:Buprenorphine / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar
chemical_list: D000701:Analgesics, Opioid; D000975:Antioxidants; D002047:Buprenorphine; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Age; Buprenorphine; Liver; Oxidative Damage; Rat