title: Recent advances in the chemistry and biology of benzothiazoles.
abstract: Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five-membered thiazole ring. This moiety has attracted considerable attention because of its wide range of pharmacological activities such as antitubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, analgesic, anti-inflammatory, antidiabetic, antitumor activity, etc. In the last few years, some novel benzothiazoles have been developed with varied biological activities. To access this scaffold in high yield and to introduce diversity, a variety of new synthetic methods have been invented. In this review, we highlight the development of novel benzothiazoles for various biological activities along with the best synthetic protocols for their synthesis.
authors: Department of Pharmaceutical Sciences, ISF College of Pharmacy, Moga, Punjab, India; Research Scholar, Punjab Technical University, Jalandhar, Punjab, India.
authors: Rupinder K
authors: RK
authors: Gill
authors: Ravindra K
authors: RK
authors: Rawal
authors: Jitender
authors: J
authors: Bariwal
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000925:Anticoagulants / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D007004:Hypoglycemic Agents
keywords: Anthelmintic; Anticancer; Antitubercular; Benzothiazoles; Mycobacterium tuberculosis; Thioformanilides