title: [Investigation and analysis of blood transfusion in 1 766 hospitalized trauma patients].
abstract: OBJECTIVE
  The study was to understand the incidence of traumatic coagulopathy and the clinical blood transfusion in hospitalized trauma patients so as to provide a reference for guiding scientific component transfusion in trauma or surgical patients.
  
  
  METHODS
  By using a software "clinical transfusion database" developed by our department, 1 766 trauma cases who suffered traumatic injury and required hospital admission between 2001 and 2012 were retrieved, and out of them 1 211 patients were given transfusion, and the transfusion-related indicators of the patients such as coagulation, hemoglobin levels before transfusion, trauma situation, massive blood transfusion and total blood transfusion were retrospectively analyzed. According total volume of blood usage during hospitalization,1 211 cases with transfusion were divided into three groups: low volume transfusion group ( ≤ 5 U, n = 471), moderate volume transfusion group (5-10 U, n = 449) and high volume transfusion group (>10 U, n = 291), then the difference of indicators among the 3 groups was compared, and the risk factors of high volume transfusion were analyzed.
  
  
  RESULTS
  There were 33 cases of coagulopathy and 52 cases of massive transfusion in trauma patients with transfusion. The transfusion rate of trauma patients was about 68.6%. There was no association between the total amount of blood transfusion and surgical grade or whether surgery. The most patients were transfused using two components (plasma and red blood cell), the ratio of plasma to RBC transfused in patients with coagulopathy was approximately 1.0. In high volume transfusion group, there were more younger and male patients with more serious injury, their infection and death were significantly higher than that in other two groups (P < 0.01).
  
  
  CONCLUSIONS
  There were approximately 69% of hospitalized trauma patients require transfusion, the patients in high volume transfusion group have two populations such as middle-aged and young men who was vulnerable to severe trauma mainly caused by accident injury or fall injury and older women who was vulnerable to osteoporotic hip fractures mainly caused by fall injuries. The coagulation disorders in the patients with trauma coagulopathy should be corrected by transfusion with high ratios of plasma to RBC. Massive transfusion (OR = 95.22), hemorrhagic shock (OR = 17.2), trauma coagulopathy (OR = 4.52) are risk factors of high volume transfusion > 10 U, and massive transfusion also is a risk factor of trauma coagulopathy (OR = 16.257). The routine dynamic monitoring of coagulation should be performed for trauma or surgical patients to guide the clinical transfusion scientifically.
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Chao-Yun
authors: CY
authors: Xi
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Yang
authors: Y
authors: Yu
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Lin-Feng
authors: LF
authors: Chen
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Li-Guo
authors: LG
authors: Zhu
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Ying
authors: Y
authors: Lu
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China.
authors: Shu-Fang
authors: SF
authors: Wang
authors: Department of Blood Transfusion, The Chinese PLA General Hospital, Beijing 100853,China. E-mail: deqingw@vip.sina.com.
authors: De-Qing
authors: DQ
authors: Wang
mesh_terms: D001778:Blood Coagulation Disorders; D001803:Blood Transfusion; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012771:Shock, Hemorrhagic