title: A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives.
abstract: A versatile synthetic procedure is described to prepare the benzimidazole-fused 1,2,4-thiadiazoles 2a-c via a methanesulfonyl chloride initiated multistep cyclization involving the intramolecular reaction of an in-situ generated carbodiimide with a thiourea unit. The structure of the intricate heterocycle 2a was confirmed by single-crystal X-ray analysis and its mechanism of formation supported by DFT computations.
authors: Department of Chemistry and Biology, Universität Siegen, Adolf-Reichwein-Straße, D-57068 Siegen, Germany.
authors: Debabrata
authors: D
authors: Samanta
authors: Department of Chemistry and Biology, Universität Siegen, Adolf-Reichwein-Straße, D-57068 Siegen, Germany.
authors: Anup
authors: A
authors: Rana
authors: Institut für Organische Chemie und Chemische Biologie, Johann Wolfgang Goethe-Universität, Max-von-Laue-Straße 7, 60438 Frankfurt am Main, Germany.
authors: Jan W
authors: JW
authors: Bats
authors: Department of Chemistry and Biology, Universität Siegen, Adolf-Reichwein-Straße, D-57068 Siegen, Germany.
authors: Michael
authors: M
authors: Schmittel
keywords: 1,2,4-thiadiazoles; DFT; carbodiimide; cyclization; dithiourea