title: Gastroesophageal reflux disease and non-digestive tract diseases.
abstract: Over the past decade, incidence of gastroesophageal reflux disease (GERD) showed an increasing trend resulting from factors, including lifestyle and dietary habits; however, both etiology and pathological mechanisms remain controversial. GERD occurs as a result of a variety of mechanisms and there is no single factor. Symptoms of GERD are often non-typical, with a likelihood of being overlooked by non-gastroenterology professionals. Therefore, improving GERD awareness in non-gastroenterology practitioners, along with early diagnosis and treatment, provide potential benefit to clinicians and patients alike. Increasing evidence suggests GERD has specific connections with a variety of non-digestive tract conditions, may contribute an aggravating compounding effect on other diseases, prolong hospitalization, and increase subsequent medical costs. This review considers and emphasizes the association between GERD and non-digestive tract conditions, including atrial fibrillation, chronic obstructive pulmonary disease, primary pulmonary fibrosis and energy metabolism related to diet.
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin Er Road 197, Shanghai, 200025, People's Republic of China.
authors: Ying
authors: Y
authors: Chen
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009765:Obesity / Q000150:complications*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D011658:Pulmonary Fibrosis / Q000150:complications*
keywords: atrial fibrillation; atypical symptom; etiology; gastroesophageal reflux disease; non-digestive tract disease