title: Gut chemosensing mechanisms.
abstract: The enteroendocrine system is the primary sensor of ingested nutrients and is responsible for secreting an array of gut hormones, which modulate multiple physiological responses including gastrointestinal motility and secretion, glucose homeostasis, and appetite. This Review provides an up-to-date synopsis of the molecular mechanisms underlying enteroendocrine nutrient sensing and highlights our current understanding of the neuro-hormonal regulation of gut hormone secretion, including the interaction between the enteroendocrine system and the enteric nervous system. It is hoped that a deeper understanding of how these systems collectively regulate postprandial physiology will further facilitate the development of novel therapeutic strategies.
authors: Arianna
authors: A
authors: Psichas
authors: Frank
authors: F
authors: Reimann
authors: Fiona M
authors: FM
authors: Gribble
mesh_terms: D000818:Animals; D017615:Enteric Nervous System / Q000502:physiology; D019858:Enteroendocrine Cells / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000166:cytology / Q000382:microbiology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D064307:Microbiota / Q000502:physiology
chemical_list: D005768:Gastrointestinal Hormones