title: Reactive oxygen species in cancer: a dance with the devil.
abstract: Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.
authors: Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: p-schumacker@northwestern.edu.
authors: Paul T
authors: PT
authors: Schumacker
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005721:Glutamate-Cysteine Ligase / Q000235:genetics*; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics*
chemical_list: D000975:Antioxidants; D005721:Glutamate-Cysteine Ligase