title: Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.
abstract: Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.
authors: Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30, Stockholm, Sweden, goran.papenberg@ki.se.
authors: Goran
authors: G
authors: Papenberg
authors: Alireza
authors: A
authors: Salami
authors: Jonas
authors: J
authors: Persson
authors: Ulman
authors: U
authors: Lindenberger
authors: Lars
authors: L
authors: Bäckman
mesh_terms: D000375:Aging / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000098:blood supply / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D007839:Functional Laterality; D014644:Genetic Variation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D010750:Phosphoproteins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D019208:Brain-Derived Neurotrophic Factor; D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; C513637:WWC1 protein, human; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase