title: (-) Epigallocatechin-3-gallate attenuates reserpine-induced orofacial dyskinesia and oxidative stress in rat striatum.
abstract: Reserpine-induced orofacial dyskinesia (OD) has been used for decades as an animal model for human tardive dyskinesia (TD) because both of them have pathophysiology strongly associated with striatal oxidative stress. Green tea catechins, especially (-) epigallocatechin-3-gallate (EGCG), have potent antioxidative effects and are able to protect against various oxidative injuries. In this study, we examined the potential protective effects of EGCG on reserpine-induced behavioral and neurochemical dysfunction in rats. Reserpine treatment (1mg/kgs.c. one injection every other day, three injections total) induced significant increases (p<0.001) in the frequency of vacuous chewing movement (VCM) and tongue protrusion (TP) as well as the duration of facial twitching (FT). EGCG treatment (100mg/kgi.p. for 11days, starting 7days before the reserpine injections) was able to prevent most of the reserpine-induced OD. Also, EGCG treatment was able to reduce the reserpine-induced lipid peroxidation (LPO) production, and enhances the antioxidation power in the striatum of reserpine-treated rats. The above results indicate that EGCG has a protective role against reserpine-induced OD, probably via its powerful antioxidative properties. Thus, EGCG may possible have a clinically relevant therapeutic effect in preventing, delaying or even treating TD.
authors: Department of Anesthesia, En Chu Kon Hospital, Sanshia District, New Taipei City 23702, Taiwan, ROC; Department of Optometry, Yuanpei University, Hsinchu 30015, Taiwan, ROC.
authors: Mao-Hsien
authors: MH
authors: Wang
authors: Department of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan, ROC.
authors: Rui-Feng
authors: RF
authors: Lin
authors: Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan, ROC; School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan, ROC.
authors: Hsiang-Chien
authors: HC
authors: Tseng
authors: Department of Psychiatry, Yuan-Shan br. of Taipei Veteran General Hospital, Yilan County 26604, Taiwan, ROC.
authors: Hung-Sheng
authors: HS
authors: Soung
authors: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, ROC.
authors: Kuo-Chi
authors: KC
authors: Chang
authors: Department of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan, ROC; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 11031, Taiwan, ROC. Electronic address: dschang580704@yahoo.com.tw.
authors: Cheng-Chia
authors: CC
authors: Tsai
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects*; D004195:Disease Models, Animal; D005978:Glutathione / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D012110:Reserpine; D002392:Catechin; C045651:epigallocatechin gallate; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: (−) Epigallocatechin-3-gallate; Catalase; Glutathione; Lipid peroxidation; Orofacial dyskinesia; Reserpine; Striatum; Superoxide dismutase