title: Auditory Evoked M100 Response Latency is Delayed in Children with 16p11.2 Deletion but not 16p11.2 Duplication.
abstract: Individuals with the 16p11.2 BP4-BP5 copy number variant (CNV) exhibit a range of behavioral phenotypes that may include mild impairment in cognition and clinical diagnoses of autism spectrum disorder (ASD). To better understand auditory processing impairments in populations with this chromosomal variation, auditory evoked responses were examined in children with the 16p11.2 deletion, 16p11.2 duplication, and age-matched controls. Stimuli consisted of sinusoidal binaural tones presented passively while children underwent recording with magnetoencephalography (MEG). The primary indicator of auditory processing impairment was the latency of the ∼100-ms "M100" auditory response detected by MEG, with the 16p11.2 deletion population exhibiting profoundly delayed M100 latencies relative to controls. This delay remained even after controlling for potential confounds such as age and cognitive ability. No significant difference in M100 latency was observed between 16p11.2 duplication carriers and controls. Additionally, children meeting diagnostic criteria for ASD (16p11.2 deletion carriers) exhibited nonsignificant latency delays when compared with the corresponding CNV carriers not meeting criteria for ASD. Present results indicate that 16p11.2 deletion is associated with auditory processing delays analogous to (but substantially more pronounced than) those previously reported in "idiopathic" ASD.
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Julian
authors: J
authors: Jenkins
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Vivian
authors: V
authors: Chow
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Lisa
authors: L
authors: Blaskey
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Emily
authors: E
authors: Kuschner
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Saba
authors: S
authors: Qasmieh
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Leah
authors: L
authors: Gaetz
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: J Christopher
authors: JC
authors: Edgar
authors: Department of Radiology.
authors: Pratik
authors: P
authors: Mukherjee
authors: Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
authors: Randall
authors: R
authors: Buckner
authors: Department of Radiology.
authors: Srikantan S
authors: SS
authors: Nagarajan
authors: Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.
authors: Wendy K
authors: WK
authors: Chung
authors: Simons Foundation, New York, NY 10010, USA.
authors: John E
authors: JE
authors: Spiro
authors: Department of Neurology, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA.
authors: Elliott H
authors: EH
authors: Sherr
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Jeffrey I
authors: JI
authors: Berman
authors: Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors: Timothy P L
authors: TP
authors: Roberts
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D001303:Auditory Cortex / Q000503:physiopathology*; D001321:Autistic Disorder / Q000503:physiopathology*; D002648:Child; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000503:physiopathology*; D058674:Chromosome Duplication; D002885:Chromosomes, Human, Pair 16; D005072:Evoked Potentials, Auditory / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology*; D015225:Magnetoencephalography; D008297:Male; D009483:Neuropsychological Tests
keywords: 16p112 deletion; 16p112 duplication; M100; autism spectrum disorder; magnetoencephalography