title: Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione.
abstract: Bioactive indolo[3,2-j]phenanthridine alkaloids, calothrixin B and its N-oxide derivative calothrixin A have been synthesized via an oxidative free radical reaction. calothrixin B is generated from the commercially available 2,4,5-trimethoxybenzaldehyde in only 7 steps. The key step in this synthesis is the Mn(OAc)3mediated oxidative free radical reaction of 9-(benzylamino)phenanthridine -7,10-dione with cyclohexenone to form 12-benzyl-12H-indolo[3,2-j]phenanthridine-7,13-dione.
authors: Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA.
authors: Su
authors: S
authors: Xu
authors: Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA.
authors: Thao
authors: T
authors: Nguyen
authors: Exchange program students from the University of "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 66013, Chieti, Italy.
authors: Irene
authors: I
authors: Pomilio
authors: Exchange program students from the University of "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 66013, Chieti, Italy.
authors: Maria C
authors: MC
authors: Vitale
authors: Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, AL 35294-1240, USA ; Comprehensive Cancer Center, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL 35294-3300, USA.
authors: Sadanandan E
authors: SE
authors: Velu
keywords: Aminophenanthridinedione; Calothrixin; Free Radical; Oxidative; Total Synthesis