title: Left ventricular systolic dysfunction in metastatic breast cancer patients: a Polish multicenter registry.
abstract: BACKGROUND
  The knowledge of the epidemiology of left ventricular systolic dysfunction (LVSD) in relationship with cardiovascular diseases, their risk factors and history of previous anticancer therapy may lead to development of safer and more effective therapeutic strategies in patients with breast cancer (BC).
  
  
  METHODS
  Oncologists from various Polish Centers reported 299 new cases of metastatic BC requiring chemotherapy. All registered previous cardiological and oncological therapies should be conducted in accordance with the mandatory guidelines.
  
  
  RESULTS
  Twelve new cases (4%) of LVSD were recognized in echocardiography before current chemotherapy. Multivariate logistic regression analysis revealed a significant association of LVSD with hypercholesterolemia (odds ratio (OR)=8.83; 95% confidence interval (CI)=1.44-54.16; p<0.02), prior myocardial infarction (OR=26.81; 95%CI=2.26-318.43; p<0.01), prior antracycline-based therapy either neoadjuvant (OR=13.21; 95%CI=2.18-80.12, p=0.005) or adjuvant (OR=6.94; 95%CI=1.003-47.985, p<0.05).
  
  
  CONCLUSIONS
  LVSD in metastatic BC reflects common negative effects of hypercholesterolemia, coronary events and neoadjuvant/adjuvant chemotherapy with anthracyclines.
authors: Department of Pulmonary Circulation and Thromboembolic Diseases, Centre of Postgraduate Medical Education, Otwock, Poland s.szmit@gmail.com.
authors: Sebastian
authors: S
authors: Szmit
authors: Department of Clinical Oncology, The University Hospital in Cracow, Cracow, Poland.
authors: Joanna
authors: J
authors: Streb
authors: Department of Oncology, Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Bydgoszcz, Poland.
authors: Wioletta
authors: W
authors: Starzec
authors: Department of Diagnosis and Treatment of Breast Cancer, Beskid Oncology Centre in Bielsko-Biała, Bielsko-Biała, Poland.
authors: Dorota
authors: D
authors: Zuziak
authors: Department of Oncology, Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Bydgoszcz, Poland.
authors: Mariusz
authors: M
authors: Kwiatkowski
authors: Department of Oncology, Medical University of Białystok, Białystok, Poland.
authors: Bogumiła
authors: B
authors: Czartoryska-Arłukowicz
authors: Department of Cancer Immunology, Poznan University of Medical Sciences, Poznań, Poland.
authors: Dariusz
authors: D
authors: Iżycki
authors: Chemotherapy Department, Regional Center of Oncology in Lodz, Łódź, Poland.
authors: Anna
authors: A
authors: Śmiałowska-Janiszewska
authors: District Hospital Department of Chemotherapy in Racibórz, Racibórz, Poland.
authors: Jerzy
authors: J
authors: Hanslik
authors: Chemotherapy Department, Regional Center of Oncology in Lodz, Łódź, Poland.
authors: Agnieszka
authors: A
authors: Bryjak
authors: West Pomeranian Oncology Center in Szczecin, Szczecin, Poland.
authors: Małgorzata
authors: M
authors: Talerczyk
authors: Department of Oncology and Propedeutic Oncology, Gdynia Oncology Center and Medical University of Gdansk, Gdynia, Poland.
authors: Jan Maciej
authors: JM
authors: Zaucha
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011044:Poland; D012042:Registries; D013599:Systole; D018487:Ventricular Dysfunction, Left
keywords: Anthracyclines; chemotherapy; left ventricular systolic dysfunction; metastatic breast cancer; risk factors