title: The first water-soluble bowl complex: molecular recognition of acetate by the biomimetic tris(imidazole) Zn(II) system at pH 7.4.
abstract: A supramolecular approach for modeling active sites of metallo-enzymes relies on the association of a metal ion bound to a tris(imidazole) core under the control of a cavity. One step further is the water-solubilization of the cavity-complex. Here, we describe the synthesis of a water-soluble bowl-ligand that has been successively achieved through an 11-step strategy from resorcinol. First insights into its coordination properties in water show that it readily binds Zn(II) at physiological pH and acts as a molecular receptor for the hydrophilic acetate guest ligand.
authors: Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR 8601, 45 rue des Saints Pères, 75006 Paris, France. olivia.reinaud@parisdescartes.fr.
authors: Stéphanie
authors: S
authors: Rat
authors: Jérôme
authors: J
authors: Gout
authors: Olivia
authors: O
authors: Bistri
authors: Olivia
authors: O
authors: Reinaud
mesh_terms: D000085:Acetates / Q000032:analysis*; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000085:Acetates; D007093:Imidazoles; D009942:Organometallic Compounds; D014867:Water; D015032:Zinc