title: Serum luteinizing hormone concentration is significantly associated with recovery of urinary function after radical prostatectomy.
abstract: OBJECTIVE
  To perform a longitudinal investigation of the correlation between functional recovery and sex hormone concentrations after radical prostatectomy (RP).
  
  
  METHODS
  A total of 72 consecutive patients undergoing RP between January 2012 and June 2013 were prospectively included and serially followed after surgery for comparative analysis. Their luteinizing hormone (LH) and total testosterone (TT) concentrations were measured before surgery and 3 and 12 months after surgery. They also filled out a health-related quality of life questionnaire before and at 1, 3, 6 and 12 months after surgery.
  
  
  RESULTS
  The mean LH concentration increased from 4.28 U/L at baseline to 5.53 U/L at 3 months and remained high at 12 months after RP (both P < 0.001). There were no significant changes in the TT concentration after RP. LH at baseline was negatively correlated with the urinary function (UF) score at 3 and 12 months after RP (P = 0.030 and 0.032, respectively). After RP, subjects with high baseline LH (n = 37) were more likely than those with low LH concentrations to report lower UF scores (P = 0.014). Multivariate analysis of variance in an interaction of time × LH concentration for UF scores indicated a significant relationship between changes in UF score and LH concentration (P = 0.004).
  
  
  CONCLUSIONS
  Radical prostatectomy affects sex hormones by increasing LH concentrations, while TT concentrations remain stable after surgery. Baseline LH concentrations are significantly associated with the recovery of urinary outcomes after RP.
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.|Department of Urology, Japan Community Health Care Organization Sendai Hospital, Sendai, Japan.
authors: Shunichi
authors: S
authors: Namiki
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Koji
authors: K
authors: Mitsuzuka
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Yasuhiro
authors: Y
authors: Kaiho
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Shigeyuki
authors: S
authors: Yamada
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Hisanobu
authors: H
authors: Adachi
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Shinichi
authors: S
authors: Yamashita
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Hideo
authors: H
authors: Saito
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Akihiro
authors: A
authors: Ito
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Haruo
authors: H
authors: Nakagawa
authors: Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Japan.
authors: Misa
authors: M
authors: Takegami
authors: Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Yoichi
authors: Y
authors: Arai
mesh_terms: D000368:Aged; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D011788:Quality of Life; D020127:Recovery of Function; D013739:Testosterone / Q000378:metabolism; D016055:Urinary Retention / Q000097:blood / Q000503:physiopathology / Q000601:surgery*
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone
keywords: hypogonadism; luteinizing hormone; prostate cancer; radical prostatectomy; testosterone