title: Role of immunoglobulins in neonatal sepsis.
abstract: Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: L
authors: L
authors: Capasso
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: Ac
authors: A
authors: Borrelli
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: J
authors: J
authors: Cerullo
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: R
authors: R
authors: Pisanti
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: C
authors: C
authors: Figliuolo
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: F
authors: F
authors: Izzo
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: M
authors: M
authors: Paccone
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: T
authors: T
authors: Ferrara
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: S
authors: S
authors: Lama
authors: Division of Neonatology, Section of Pediatrics, Department of Translational Medical Science, University Federico II Naples, Italy, ( letizia.capasso@gmail.com ).
authors: F
authors: F
authors: Raimondi
keywords: immunoglobulins; neonate; sepsis