title: Investigating the role of surface micro/nano structure in cell adhesion behavior of superhydrophobic polypropylene/nanosilica surfaces.
abstract: The main aim of the current study was to investigate the effects of different topographical features on the biological performance of polypropylene (PP)/silica coatings. To this end, a novel method including combined use of nanoparticles and non-solvent was used for preparation of superhydrophobic PP coatings. The proposed method led to a much more homogeneous appearance with a better adhesion to the glass substrate. Moreover, a notable reduction was observed in the required contents of nanoparticles (100-20 wt% with respect to the polymer) and non-solvent (35.5-9 vol%) for achieving superhydrophobicity. Surface composition and morphology of the coatings were also investigated via X-ray photoelectron spectroscopy and scanning electron microscopy. Based on both qualitative and quantitative evaluations, it was found that the superhydrophobic coatings with only nano-scale roughness strongly prevented adhesion and proliferation of 4T1 mouse mammary tumor cells as compared to the superhydrophobic surfaces with micro-scale structure. Such results demonstrate that the cell behavior could be controlled onto the polymer and nanocomposite-based surfaces via tuning the surface micro/nano structure.
authors: Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, Tehran, Iran.
authors: Iman
authors: I
authors: Hejazi
authors: Department of Chemical Engineering, Islamic Azad University, Shahrood Branch, P.O. Box 36155-163, Shahrood, Iran.
authors: Javad
authors: J
authors: Seyfi
authors: Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Ehsan
authors: E
authors: Hejazi
authors: Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, Tehran, Iran. Electronic address: Gsadeghi@aut.ac.ir.
authors: Gity Mir Mohamad
authors: GM
authors: Sadeghi
authors: Department of Polymer Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, P.O. Box 19585-466, Tehran, Iran.
authors: Seyed Hassan
authors: SH
authors: Jafari
authors: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Strasse 6, D-01069 Dresden, Germany; Iran Polymer and Petrochemical Institute, P.O. Box 14965/115, Tehran, Iran.
authors: Hossein Ali
authors: HA
authors: Khonakdar
mesh_terms: D000818:Animals; D002074:Butanones; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011126:Polypropylenes / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents; D017155:Wettability
chemical_list: D002074:Butanones; D020099:Coated Materials, Biocompatible; D011126:Polypropylenes; D012997:Solvents; C005222:methylethyl ketone; D012822:Silicon Dioxide
keywords: Cell adhesion; Micro/nano structure; Nanosilica; Non-solvent; Superhydrophobic