title: Synthesis of acyl carbamates via four component Pd-catalyzed carbonylative coupling of aryl halides, potassium cyanate, and alcohols.
abstract: A simple and mild method is demonstrated for assembling acyl carbamates through a base-free four-component Pd-catalyzed carbonylation of aryl halides in the presence of potassium cyanate and alcohols in a two-chamber system. This approach produces a wide range of aryl acyl carbamates in good to excellent yields from the corresponding aryl bromides or iodides with near-stoichiometric carbon monoxide. In addition, the method can be extended to the synthesis of primary amides thereby expanding the usefulness of cyanate as an ammonia equivalent.
authors: Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University , Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
authors: Hongfei
authors: H
authors: Yin
authors: Angelina M
authors: AM
authors: de Almeida
authors: Mauro V
authors: MV
authors: de Almeida
authors: Anders T
authors: AT
authors: Lindhardt
authors: Troels
authors: T
authors: Skrydstrup
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003485:Cyanates / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000577:Amides; D002219:Carbamates; D003485:Cyanates; D006846:Hydrocarbons, Halogenated; D010165:Palladium; D000641:Ammonia; C024835:potassium cyanate