title: Maltodextrin fast dissolving films for quercetin nanocrystal delivery. A feasibility study.
abstract: The objective of this study was to evaluate the feasibility to prepare fast dissolving films as quercetin nanocrystal delivery systems, using maltodextrins as film forming material and glycerin as plasticizer, with the goal of enhancing quercetin oral bioavailability. Quercetin nanosuspensions were prepared using a high-pressure homogenizer, and then directly used to prepare the films by a casting method. Spectroscopic and calorimetric analysis evidenced that reduction of quercetin size at nanoscale and incorporation in maltodextrin films do not affect the solid state of the active ingredient. The loading of quercetin nanocrystals into the film determined a slight variation of film elasticity and ductility. Indeed, the elastic modulus of the loaded films resulted about a half of the placebo ones, while the elongation at break increased four folds. Free and film loaded quercetin nanocrystals showed a comparable dissolution rate, much higher than that of bulk quercetin.
authors: Dept. Scienze della Vita e dell'Ambiente, University of Cagliari, Cagliari 09124, Italy.
authors: Francesco
authors: F
authors: Lai
authors: Dept. Scienze Farmaceutiche, University of Milan, Milan 20133, Italy.
authors: Ilaria
authors: I
authors: Franceschini
authors: Dept. Scienze della Vita e dell'Ambiente, University of Cagliari, Cagliari 09124, Italy.
authors: Francesco
authors: F
authors: Corrias
authors: Dept. Scienze Farmaceutiche, University of Milan, Milan 20133, Italy.
authors: Maria Chiara
authors: MC
authors: Sala
authors: Dept. Scienze Farmaceutiche, University of Milan, Milan 20133, Italy.
authors: Francesco
authors: F
authors: Cilurzo
authors: Dept. Scienze della Vita e dell'Ambiente, University of Cagliari, Cagliari 09124, Italy. Electronic address: sinico@unica.it.
authors: Chiara
authors: C
authors: Sinico
authors: Dept. Scienze Farmaceutiche, University of Milan, Milan 20133, Italy.
authors: Elena
authors: E
authors: Pini
mesh_terms: D005240:Feasibility Studies; D053758:Nanoparticles / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry*; D012995:Solubility; D013535:Suspensions / Q000737:chemistry
chemical_list: D011134:Polysaccharides; D013535:Suspensions; C008315:maltodextrin; D011794:Quercetin
keywords: Fast dissolving films; Maltodextrins; Nanocrystals; Quercetin