title: Histologic changes in diabetic gastroparesis.
abstract: The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters at the level of the enteric nervous system, smooth muscle abnormalities, loss of interstitial cells of Cajal, and changes in the macrophage population resident in the muscle wall. This article reviews the current understanding with a focus on data from human studies when available.
authors: Enteric NeuroScience Program, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: Farrugia.gianrico@mayo.edu.
authors: Gianrico
authors: G
authors: Farrugia
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005746:Gastric Emptying / Q000502:physiology; D018589:Gastroparesis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D056885:Interstitial Cells of Cajal / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D009130:Muscle, Smooth / Q000473:pathology / Q000503:physiopathology; D013270:Stomach / Q000294:innervation / Q000473:pathology / Q000503:physiopathology
keywords: Enteric nerves; Gastric emptying; Interstitial cells of Cajal; Macrophages; Smooth muscle; Vagus