title: Neuroendocrine carcinoma of the mammary gland in a dog.
abstract: A 10-year-old female border collie was presented with a mass (2 cm diameter) in the fifth mammary gland. The mass was located in the subcutis and the cut surface was grey-white in colour. Microscopically, the mass was composed of tumour cells arranged in nests of various sizes separated by delicate fibrovascular stroma. The tumour cells had small, round hypochromatic nuclei and abundant cytoplasm. Metastases were observed in the inguinal lymph node. Immunohistochemically, most tumour cells expressed cytokeratin (CK) 20, chromogranin A, neuron-specific enolase, synaptophysin and oestrogen receptor-β, but not low molecular weight CK (CAM5.2), p63 and insulin. Ultrastructurally, the tumour cells contained a large number of electron-dense granules corresponding to neuroendocrine granules. Based on these findings, this case was diagnosed as a neuroendocrine carcinoma of the mammary gland.
authors: Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors: R
authors: R
authors: Nakahira
authors: Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. Electronic address: michishita@nvlu.ac.jp.
authors: M
authors: M
authors: Michishita
authors: Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors: H
authors: H
authors: Yoshimura
authors: Department of Comparative Cellular Biology, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors: H
authors: H
authors: Hatakeyama
authors: Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
authors: K
authors: K
authors: Takahashi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: dog; mammary gland; neuroendocrine carcinoma