title: Disentangling detector data in XFEL studies of temporally resolved solution state chemistry.
abstract: With the arrival of X-ray Free Electron Lasers (XFELs), 2D area detectors with a large dynamic range for detection of hard X-rays with fast readout rates are required for many types of experiments. Extracting the desired information from these detectors has been challenging due to unpredicted fluctuations in the measured images. For techniques such as time-resolved X-ray Diffuse Scattering (XDS), small differences in signal intensity are the starting point for analysis. Fluctuations in the total detected signal remain in the differences under investigation, obfuscating the signal. To correct such artefacts, Singular Value Decomposition (SVD) can be used to identify and characterize the observed detector fluctuations and assist in assigning some of them to variations in physical parameters such as X-ray energy and X-ray intensity. This paper presents a methodology for robustly identifying, separating and correcting fluctuations on area detectors based on XFEL beam characteristics, to enable the study of temporally resolved solution state chemistry on the femtosecond timescale.
authors: Molecular Movies, Department of Physics, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark. mmee@fysik.dtu.dk.
authors: Tim
authors: T
authors: Brandt van Driel
authors: Kasper Skov
authors: KS
authors: Kjær
authors: Elisa
authors: E
authors: Biasin
authors: Kristoffer
authors: K
authors: Haldrup
authors: Henrik Till
authors: HT
authors: Lemke
authors: Martin Meedom
authors: MM
authors: Nielsen
mesh_terms: D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D054018:Lasers, Excimer; D012996:Solutions / Q000737:chemistry*; D013997:Time Factors; D014965:X-Rays
chemical_list: D012996:Solutions