title: Impact of early biliary complications on long-term outcomes in adult-to-adult living donor liver transplant recipients.
abstract: BACKGROUND
  An adult-to-adult living donor liver transplant (LDLT) has emerged as a possible option to help alleviate the organ shortage. The aim of this study was to analyze our experience with biliary complications in LDLT recipients and to identify their risk factors for biliary complications. This paper aimed to describe therapeutic interventions and to evaluate the impact of biliary complications on long-term patient and graft survival rates.
  
  
  METHODS
  We evaluated biliary complications in a cohort of 120 LDLT recipients at a single institution and studied the impact on long-term graft and patient survival.
  
  
  RESULTS
  Of the 120 recipients, 26 (21.7%) developed biliary complications. Endoscopy was the initial choice of treatment for recipients with biliary complications. The median time for resolution of bile leaks was 37 days; for resolution of strictures, 82 days. A decreased risk of biliary complications was associated with an interrupted duct-to-duct (versus continuous choledocho-choledochostomy) (hazard ratio [HR]=0.22, P=0.002) and a Roux-en-Y hepaticojejunostomy (HR=0.13, P<0.001). In multivariate analysis of factors associated with graft failure and patient mortality, biliary complications were unrelated to long term (3 and 5 years) graft failure or patient mortality.
  
  
  CONCLUSIONS
  In our study LDLT recipients had a 21.7% incidence of biliary complications, however, with successful endoscopic techniques, long-term patient and graft survival rates were not negatively affected.
authors: Department of Surgery, University of Minnesota Minneapolis, MN, USA - chinni@umn.edu.
authors: Jennifer
authors: J
authors: Leiting
authors: Mustafa
authors: M
authors: Arain
authors: Martin L
authors: ML
authors: Freeman
authors: David M
authors: DM
authors: Radosevich
authors: Raja
authors: R
authors: Kandaswamy
authors: Mohamed
authors: M
authors: Hassan
authors: Julie
authors: J
authors: Thompson
authors: John
authors: J
authors: Lake
authors: Timothy L
authors: TL
authors: Pruett
authors: Srinath
authors: S
authors: Chinnakotla
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001658:Biliary Fistula / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery; D001662:Biliary Tract Surgical Procedures / Q000009:adverse effects; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome