title: Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases.
abstract: A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situ generation of a nucleic acid-mimicking CoA-Au(I) coordination polymer (CP). Moreover, the potency of this assay for HAT-targeted drug discovery was proved by screening HAT inhibitors.
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China. niezhou.hnu@gmail.com.
authors: Siyu
authors: S
authors: Chen
authors: Yong
authors: Y
authors: Li
authors: Yufang
authors: Y
authors: Hu
authors: Yitao
authors: Y
authors: Han
authors: Yan
authors: Y
authors: Huang
authors: Zhou
authors: Z
authors: Nie
authors: Shouzhuo
authors: S
authors: Yao
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D003065:Coenzyme A / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D051548:Histone Acetyltransferases / Q000378:metabolism*; D009696:Nucleic Acids / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009696:Nucleic Acids; D009930:Organic Chemicals; D011108:Polymers; C098798:SYBR Green II; D006046:Gold; D051548:Histone Acetyltransferases; D003065:Coenzyme A