title: Magnetic resonance imaging of electrolysis.
abstract: This study explores the hypothesis that Magnetic Resonance Imaging (MRI) can image the process of electrolysis by detecting pH fronts. The study has relevance to real time control of cell ablation with electrolysis. To investigate the hypothesis we compare the following MR imaging sequences: T1 weighted, T2 weighted and Proton Density (PD), with optical images acquired using pH-sensitive dyes embedded in a physiological saline agar solution phantom treated with electrolysis and discrete measurements with a pH microprobe. We further demonstrate the biological relevance of our work using a bacterial E. Coli model, grown on the phantom. The results demonstrate the ability of MRI to image electrolysis produced pH changes in a physiological saline phantom and show that these changes correlate with cell death in the E. Coli model grown on the phantom. The results are promising and invite further experimental research.
authors: Graduate Program in Biophysics, University of California Berkeley, Berkeley, CA 94720.
authors: Arie
authors: A
authors: Meir
authors: Medical Imaging Department; Faculty of Health Professions, Al-Quds University/Abu Dies/Jerusalem.
authors: Mohammad
authors: M
authors: Hjouj
authors: Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA 94720.
authors: Liel
authors: L
authors: Rubinsky
authors: 1] Graduate Program in Biophysics, University of California Berkeley, Berkeley, CA 94720 [2] Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA 94720.
authors: Boris
authors: B
authors: Rubinsky