title: The preventive effect of oxytocin to Cisplatin-induced neurotoxicity: an experimental rat model.
abstract: Peripheral neurotoxicity is a frequent dose-limiting side effect of the chemotherapeutic agent cisplatin. This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. Forty-four adult female rats were included in the study. Thirty-six rats were administered intraperitoneally (i.p.) single dose cisplatin 10 mg/kg and divided in to 3 groups. The first group (n=12) received saline i.p., whereas the second group (n=12) and the third group (n=12) were injected with 80 µg/kg and 160 µg/kg OT, respectively, for 10 days. The remaining 8 rats served as the control group. Electromyography (EMG) studies were recorded and blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF)-α, and glutathione (GSH) levels. EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the nontreated cisplatin-injected rats compared with the control group (P<0.005). Also, nontreated cisplatin-injected rats showed significantly higher TNF-α and MDA levels and lower GSH level than control group. The administration of OT significantly ameliorated the EMG alterations, suppressed oxidative stress and inflammatory parameters, and increased antioxidative capacity. We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity.
authors: Division of Medical Oncology, Tepecik Education and Research Hospital, Gaziler Caddesi No. 468, Yenisehir, 35110 Izmir, Turkey.
authors: Tulay
authors: T
authors: Akman
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors: Levent
authors: L
authors: Akman
authors: Department of Physiology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors: Oytun
authors: O
authors: Erbas
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors: Mustafa Cosan
authors: MC
authors: Terek
authors: Department of Physiology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors: Dilek
authors: 0000-0002-4505-0939
authors: D
authors: Taskiran
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, Izmir, Turkey.
authors: Aydin
authors: A
authors: Ozsaran
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004576:Electromyography; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D010121:Oxytocin; D005978:Glutathione; D002945:Cisplatin