title: FUN-L: gene prioritization for RNAi screens.
abstract: BACKGROUND
  Most biological processes remain only partially characterized with many components still to be identified. Given that a whole genome can usually not be tested in a functional assay, identifying the genes most likely to be of interest is of critical importance to avoid wasting resources.
  
  
  RESULTS
  Given a set of known functionally related genes and using a state-of-the-art approach to data integration and mining, our Functional Lists (FUN-L) method provides a ranked list of candidate genes for testing. Validation of predictions from FUN-L with independent RNAi screens confirms that FUN-L-produced lists are enriched in genes with the expected phenotypes. In this article, we describe a website front end to FUN-L.
  
  
  METHODS
  The website is freely available to use at http://funl.org
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Jonathan G
authors: JG
authors: Lees
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Jean-Karim
authors: JK
authors: Hériché
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Ian
authors: I
authors: Morilla
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: José M
authors: JM
authors: Fernández
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Priit
authors: P
authors: Adler
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Martin
authors: M
authors: Krallinger
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Jaak
authors: J
authors: Vilo
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Alfonso
authors: A
authors: Valencia
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Jan
authors: J
authors: Ellenberg
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Juan A
authors: JA
authors: Ranea
authors: Research Department of Structural & Molecular Biology, University College London, London, UK, Cell Biology/Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, Inflamex-Laboratoire Analyse Géométrie et Applications, Université Paris Nord-Sorbonne, France, Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO) and Spanish National Bioinformatics Institute (INB), Madrid, Spain, Institute of Molecular and Cell Biology, and Institute of Computer Science, University of Tartu, Tartu, Estonia and Department of Molecular Biology and Biochemistry-CIBER de Enfermedades Raras, University of Malaga, Malaga, Spain.
authors: Christine
authors: C
authors: Orengo
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining / Q000379:methods*; D053263:Gene Regulatory Networks; D006801:Humans; D010641:Phenotype; D034622:RNA Interference; D012984:Software