title: Pathologic patterns of interleukin 10 expression--a review.
abstract: Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription start site and three single nucleotide polymorphisms (SNPs) -1082(G/A), -819(C/T) and -592(C/A). A large number of studies have shown that IL-10 gene polymorphisms are associated with different diseases and play an important role in pathophysiology and clinical course of these diseases. This review summarizes published literature knowledge about the association of IL-10 polymorphisms and expression patterns with asthma, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, rheumatoid arthritis, tuberculosis and some neoplasms.
authors: Department of Medical Biochemistry, Special Hospital for Medical Rehabilitation Varaždinske Toplice, Varaždinske Toplice, Croatia.
authors: Jasenka
authors: J
authors: Trifunović
authors: Center of Excellence Medical Publications, EMD Serono Research and Development Institute, Billerica, United States of America.
authors: Larisa
authors: L
authors: Miller
authors: Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre Osijek, Osijek, Croatia.
authors: Željko
authors: Ž
authors: Debeljak
authors: Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre Osijek, Osijek, Croatia.
authors: Vesna
authors: V
authors: Horvat
mesh_terms: D000818:Animals; D018900:Dinucleotide Repeats; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C556062:IL10 protein, mouse; D016753:Interleukin-10
keywords: autoimmune diseases; inflammatory diseases; interleukin 10; neoplasms; polymorphisms, genetic