title: Health-related quality of life in children with food allergy and their parents: a systematic review of the literature.
abstract: BACKGROUND
  Health-related quality of life (HRQoL) in food-allergic children and their parents can be assessed using generic and specific questionnaires.
  
  
  OBJECTIVE
  We investigated whether HRQoL scores in food-allergic children and their parents were similar to normative data and whether they were correlated.
  
  
  METHODS
  We searched PubMed, Scopus, and the New York Academy of Medicine Grey Literature Report site. Electronic searches were supplemented by perusal of the references of the papers retrieved.
  
  
  RESULTS
  Seventeen studies were eligible. Two studies compared total HRQoL scores for children with food allergy and normative data and found no significant differences. Six studies compared HRQoL questionnaire subdomain scores for children with normative data, and 4 studies compared the same scores for parents with normative data. Children with food allergy scored worse in subdomains including bodily pain, physical functioning, mental health, general health, and emotional, social, and psychological quality of life. However, they performed better in physical health, and had fewer limitations in schoolwork due to behavioral problems. Parents performed better in subdomains such as physical and environmental health, social and psychological health, and family cohesion but scored worse on social health, overall quality of life, emotional health, impact on parental time, and limitations in usual family activities. Statistically significant results for these subdomains were not invariably corroborated by subsequent studies. No study provided data on the correlation between children's HRQoL and that of their parents.
  
  
  CONCLUSIONS
  HRQoL of food-allergic children and their parents may differ from that of the normative population in certain subdomains. However, the evidence was not sufficient to draw robust conclusions.
authors: Z
authors: Z
authors: Morou
authors: A
authors: A
authors: Tatsioni
authors: I D K
authors: ID
authors: Dimoliatis
authors: N G
authors: NG
authors: Papadopoulos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents / Q000523:psychology*; D011788:Quality of Life