title: Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability.
abstract: A new method was developed through an efficient Förster resonance energy transfer (FRET) from guanidinium-pendant oligofluorene to green fluorescent protein (GFP) for specifically screening membrane-disrupting antibiotics to which bacteria have difficulty developing resistance.
authors: Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. wangshu@iccas.ac.cn lvft@iccas.ac.cn.
authors: Hui
authors: H
authors: Chen
authors: Bing
authors: B
authors: Wang
authors: Jiangyan
authors: J
authors: Zhang
authors: Chenyao
authors: C
authors: Nie
authors: Fengting
authors: F
authors: Lv
authors: Libing
authors: L
authors: Liu
authors: Shu
authors: S
authors: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects; D005449:Fluorenes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D049452:Green Fluorescent Proteins / Q000737:chemistry / Q000378:metabolism; D019791:Guanidine / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D008958:Models, Molecular; D011487:Protein Conformation; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D005449:Fluorenes; D049452:Green Fluorescent Proteins; C041509:fluorene; D019791:Guanidine