title: 90Yttrium PET/MR-based dosimetry after liver radioembolization (SIRT).
abstract: Biodistribution and dosimetric aspects are important issues in the preparation realization of radionuclide therapies and thus play an emerging role in radioembolization of liver malignancies. Biodistribution assessment of liver selective internal radiotherapy (SIRT) has been shown feasible using PET/CT PET/magnetic resonance (MR). Whereas prospective dosimetry using 99mTc macroaggregated albumin SPECT/CT is discussed controversially, retrospective 90Y PET/CT has been shown feasible for dosimetry of SIRT in recent studies. Considering the advantages of PET/MR with regard to lesion detection radiation dose reduction compared to PET/CT, especially when repeated scanning is intended, we investigated the use of PET/MR for dosimetry of liver SIRT.
authors: From the *Departments of Nuclear Medicine, and †Radiology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
authors: Michael
authors: M
authors: Wissmeyer
authors: Bénédicte M A
authors: BM
authors: Delattre
authors: Habib
authors: H
authors: Zaidi
authors: Sylvain
authors: S
authors: Terraz
authors: Osman
authors: O
authors: Ratib
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy* / Q000628:therapy; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes