title: Reduction of renal function during mechanical ventilation of healthy lungs in an animal biomodel.
abstract: OBJECTIVE
  To identify factors involved in reno-pulmonary interactions during mechanical ventilation.
  
  
  METHODS
  The study included a total of 25 domestic piglets. The animals were divided into three groups based on different strategies of ventilation. Group A; spontaneously breathing piglets; group B animals ventilated with tidal volume of 6 ml.kg-1 and group C with animals ventilated with tidal volume 10 ml.kg-1. Clinical monitoring and laboratory tests were performed for all groups at baseline and then at 1 hour and 12 hours for groups B and C. Ventilation indices, hemodynamics, urine output, creatinine clearance, glomerular filtration index, fractional excretion of sodium, free water clearance and tissue samples were recorded. The data obtained were statistically analysed.
  
  
  RESULTS
  Lower creatinine clearance and renal indices were seen in group B (p < 0.05) and in group C (p < 0.001) at 1 hour, and a difference in urine output for group C (p < 0.01) compared to group A was observed. At 12 hours, there was a further reduction in creatinine clearance and renal indices for group B (p < 0.05) and group C (p < 0.01). The lung mechanics and hemodynamics were not significantly influenced.
  
  
  CONCLUSIONS
  The study showed a causal relationship between renal dysfunction and positive pressure mechanical ventilation with respect to tidal volume and time (Tab. 4, Fig. 2, Ref. 17).
authors: J
authors: J
authors: Kobr
authors: J
authors: J
authors: Fremuth
authors: L
authors: L
authors: Sasek
authors: P
authors: P
authors: Jehlicka
authors: R
authors: R
authors: Hrdlicka
authors: J
authors: J
authors: Racek
authors: O
authors: O
authors: Hes
authors: J
authors: J
authors: Koppl
authors: K
authors: K
authors: Pizingerova
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology; D007668:Kidney / Q000473:pathology*; D007677:Kidney Function Tests; D008297:Male; D011175:Positive-Pressure Respiration; D011897:Random Allocation; D012016:Reference Values; D051437:Renal Insufficiency / Q000209:etiology* / Q000503:physiopathology*; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D013552:Swine; D013990:Tidal Volume
chemical_list: D015415:Biomarkers