title: Congenital hypothyroidism and concurrent renal insufficiency in a kitten.
abstract: A 3-month-old male domestic short-hair kitten was presented with chronic constipation and disproportionate dwarfism. Radiographs of the long bones and spine revealed delayed epiphyseal ossification and epiphyseal dysgenesis. Diagnosis of congenital primary hypothyroidism was confirmed by low serum total thyroxine and high thyroid stimulating hormone concentrations. Appropriate supplementation of levothyroxine was instituted. The kitten subsequently developed mild renal azotaemia and renal proteinuria, possibly as a consequence of treatment or an unmasked congenital renal developmental abnormality. Early recognition, diagnosis and treatment are vital as alleviation of clinical signs may depend on the cat's age at the time of diagnosis.
authors: Department of Companion Animal Clinical Studies, University of Pretoria, South Africa; Department of Veterinary Clinical Sciences, Purdue University, United States of America. lim152@purdue.edu.
authors: Chee Kin
authors: CK
authors: Lim
authors: Chantal T
authors: CT
authors: Rosa
authors: Yolanda
authors: Y
authors: de Witt
authors: Johan P
authors: JP
authors: Schoeman
mesh_terms: D000818:Animals; D053099:Azotemia / Q000175:diagnosis / Q000662:veterinary*; D002371:Cat Diseases / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D002415:Cats; D003409:Congenital Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D004392:Dwarfism / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013974:Thyroxine