title: Antiviral effect of lithium chloride on infection of cells by porcine parvovirus.
abstract: Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo.
authors: Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
authors: Ye
authors: Y
authors: Chen
authors: Huichao
authors: H
authors: Yan
authors: Hao
authors: H
authors: Zheng
authors: Yuzhen
authors: Y
authors: Shi
authors: Lingsuang
authors: L
authors: Sun
authors: Chong
authors: C
authors: Wang
authors: Jingchen
authors: J
authors: Sun
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D018021:Lithium Chloride / Q000494:pharmacology*; D010322:Parvoviridae Infections / Q000662:veterinary* / Q000821:virology; D028323:Parvovirus, Porcine / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D053585:Virus Attachment / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D018021:Lithium Chloride