title: GATA Transcription Factors in Pregnancy.
abstract: GATA transcription factors are Zinc finger members which perform a variety of important functions within the 3-germ layers as well as in extra embryonic endoderm during embryonic development. Distinct roles for GATA transcription factors have previously been identified in hematopoietic, the cardiac vascular system, the central neural system, as well as respiratory and intestinal systems. However, the role of GATA transcription factors in trophoblast lineage and placental development is far more complete. This review focuses on the roles of GATA transcription factors during pregnancy: the establishment of trophoblast lineage, trophoectoderm maintenance, trophoblast differentiation and the pathogenesis of placenta-related diseases of pregnancy.
authors: Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, USA.
authors: Ying
authors: Y
authors: Chen
authors: Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, USA.
authors: Kai
authors: K
authors: Wang
authors: Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, USA ; Department of Obstetrics, Gynecology and Women's Health, Spectrum Health Medical Group, USA.
authors: Richard
authors: R
authors: Leach
keywords: GATA transcription factors; Pregnancy; Trophoblast