title: Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats.
abstract: In the current study, we examined the protective effect of hydroferrate fluid MRN-100 against the carcinogen methylnitronitrosoguanidine (MNNG)-induced gastric and esophageal cancer in rats. MRN-100 is an iron-based compound composed of bivalent and trivalent ferrates. At 33 weeks post treatment with MNNG, rats were killed and examined for the histopathology of esophagus and stomach; liver, spleen, and total body weight; and antioxidant levels in the blood and stomach tissues. Results showed that 17/20 (85%) gastroesophageal tissues from carcinogen MNNG-treated rats developed dysplasia and cancer, as compared to 8/20 (40%) rats treated with MNNG plus MRN-100. In addition, MRN-100 exerted an antioxidant effect in both the blood and stomach tissues by increasing levels of GSH, antioxidant enzymes SOD, CAT, and GPx, and total antioxidant capacity (TAC) level. This was accompanied by a reduction in the total free-radical and malondialdehyde levels. Furthermore, MRN-100 protected against body and organ weight loss. Thus, MRN-100 exhibited significant cancer chemopreventive activity by protecting tissues against oxidative damage in rats, which may suggest its effectiveness as an adjuvant for the treatment of gastric/esophageal carcinoma.
authors: 1. Department of Otolaryngology, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA.
authors: Mamdooh H
authors: MH
authors: Ghoneum
authors: 2. Department of Zoology, Faculty of Science, University of Mansoura, Mansoura 35516, Egypt.
authors: Nariman K
authors: NK
authors: Badr El-Din
authors: 3. Drug and Radiation Research Department, National Center for Radiation and Research Technology, P.O. Box 29 Nasr City, Cairo, Egypt.
authors: Salma M
authors: SM
authors: Abdel Fattah
authors: 4. Department of Internal Medicine, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA.
authors: Deyu
authors: D
authors: Pan
authors: 5. Department of Pathology, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA.
authors: Lucilene
authors: L
authors: Tolentino
mesh_terms: D000818:Animals; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005609:Free Radicals / Q000097:blood; D007501:Iron / Q000627:therapeutic use*; D008769:Methylnitronitrosoguanidine; D009929:Organ Size; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000627:therapeutic use*; D017208:Rats, Wistar; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D005609:Free Radicals; D020011:Protective Agents; D008769:Methylnitronitrosoguanidine; C017311:ferrate ion; D007501:Iron
keywords: anti-oxidant; dysplasia; gastric cancer; hydroferrate