title: Clinicopathological study of sporadic Burkitt lymphoma in children.
abstract: BACKGROUND
  Non-Hodgkin lymphoma is the fourth most common malignant tumors in children, Burkitt lymphoma (BL) accounts for 30-50% of all pediatric lymphomas. The aim of this study was to investigate the clinicopathologic features, immunophenotype, Epstein-Barr virus (EBV) infection and c-myc gene rearrangement of sporadic BL in children.
  
  
  METHODS
  Ninety-two cases of pediatric BL were retrospectively analyzed for clinical features, immunohistochemistry, EBV-encoded RNA (EBER) status by in situ hybridization and c-myc gene rearrangement by fluorescence in situ hybridization.
  
  
  RESULTS
  In the 92 cases, male is predominant in sex distribution (M: F = 3.38:1). The average age at diagnosis was 4.97 years. Polypoid BL showed a lower clinical stage (P = 0.002), and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome (P = 0.024 and 0.053, respectively). The positive expression of CDl0, B-cell lymphoma-6, MUMl and EBER were 95.7% (88 cases), 92.4% (85 cases), 22.8% (21 cases), 41.3% (38 cases), respectively. The expression of MUM1 were not associated with EBV infection status (P = 1.000). c-myc gene rearrangement was detected in 94.6% (87/92). Clinical treatment information for 54 cases was collected, 21 patients died of tumor after surgery alone, 33 patients received surgery and chemotherapy, and of which six patients died shortly afterwords (MUM1 positive expression in 3 cases, P = 0.076).
  
  
  CONCLUSIONS
  The anatomical location, growth pattern and serum albumin level of BL were associated with biological behavior. MUM1 may be a potential adverse prognostic marker, and not associated with EBV infection status.
authors: Hui
authors: H
authors: Huang
authors: Zhi-Liang
authors: ZL
authors: Liu
authors: Hua
authors: H
authors: Zeng
authors: Shou-Hua
authors: SH
authors: Zhang
authors: Chuan-Sheng
authors: CS
authors: Huang
authors: Hong-Yan
authors: HY
authors: Xu
authors: Yan
authors: Y
authors: Wu
authors: Song-Tao
authors: ST
authors: Zeng
authors: Feng
authors: F
authors: Xiong
authors: Department of Pathology, Jiangxi Children's Hospital, Nanchang, Jiangxi 330006, China.
authors: Wen-Ping
authors: WP
authors: Yang
mesh_terms: D000293:Adolescent; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D050835:Interferon Regulatory Factors / Q000378:metabolism; D008297:Male; D017678:Sex Distribution; D000099218:Interferon Regulatory Factor-4
chemical_list: D050835:Interferon Regulatory Factors; D000099218:Interferon Regulatory Factor-4