title: Irisin as an exercise-stimulated hormone binding crosstalk between organs.
abstract: Irisin is a newly discovered 112 amino acid residues' glycosylated protein hormone that was firstly found up-regulated by exercise-induced peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and then play an important role in circulation so as to target other organs. It conducts many downstream events including osteoblast differentiation, nerve cell and β-cell regeneration and so on. In clinical research, non-inflammation and inflammation related diseases correlated with basal level of irisin and they benefited from exercise-induced irisin endocrinology.
authors: College of Health Science, Wuhan Sports University, Wuhan, China. liujun@wipe.edu.cn.
authors: J
authors: J
authors: Liu
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*
chemical_list: C577593:FNDC5 protein, human; C571428:FNDC5 protein, mouse; D005353:Fibronectins