title: Emerging options for the treatment of type 2 diabetes in Chinese patients: focus on arterial function and alogliptin.
abstract: Type 2 diabetes mellitus (T2DM) has become a worldwide health problem, and the rate of it is growing greatly in the People's Republic of China every year. T2DM could cause macrovascular and microvascular complications that lead to an increase in arterial wall thickness, endothelial dysfunction, calcification, and - finally - to an increase in arterial stiffness and arterial dysfunction. Alogliptin, a new selective inhibitor of dipeptidyl peptidase 4, has shown its great antihyperglycemia effect in T2DM patients. The clinical trial data from the People's Republic of China was similar to other global and Asian trials. This could provide some choice for clinical physicians to the treatment of T2DM.
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, People's Republic of China.
authors: Hongyu
authors: H
authors: Wang
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, People's Republic of China.
authors: Jinbo
authors: J
authors: Liu
authors: Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, People's Republic of China.
authors: Hongwei
authors: H
authors: Zhao
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D044466:Asian People; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology / Q000208:ethnology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology / Q000208:ethnology / Q000503:physiopathology; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D012307:Risk Factors; D016896:Treatment Outcome; D014498:Uracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D059289:Vascular Stiffness / Q000187:drug effects*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D010880:Piperidines; D014498:Uracil; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4; C520853:alogliptin
keywords: People’s Republic of China; alogliptin; arterial function; type 2 diabetes mellitus