title: Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines.
abstract: A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed. The reaction employs cheap copper as the catalyst and K2S2O8 as the oxidant under mild conditions. Various alkenes and P-radical precursors are compatible with this transformation. Preliminary mechanistic studies reveal that the addition of the P-radical may initiate the reaction, and then oxidative cyclization may be achieved to afford the desired product.
authors: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. yangshd@lzu.edu.cn.
authors: Hong-Yu
authors: HY
authors: Zhang
authors: Liu-Liang
authors: LL
authors: Mao
authors: Bin
authors: B
authors: Yang
authors: Shang-Dong
authors: SD
authors: Yang
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D010766:Phosphorylation
chemical_list: D005609:Free Radicals; D007211:Indoles; C057812:indoline; D003300:Copper