title: Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin.
abstract: Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.
authors: Department of Pharmacognosy, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Corina
authors: C
authors: Danciu
authors: Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Camelia
authors: C
authors: Oprean
authors: Department of Toxicology, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Dorina E
authors: DE
authors: Coricovac
authors: Department of Pathology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors: Cioca
authors: C
authors: Andreea
authors: Department of Microscopic Morphology/Histology, Angiogenesis Research Center, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Anca
authors: A
authors: Cimpean
authors: Pharmazentrum Frankfurt/Center for Drug Research, Development, and Safety, Clinic of J. W. Goethe University, Frankfurt, Germany.
authors: Heinfried
authors: H
authors: Radeke
authors: Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Codruta
authors: C
authors: Soica
authors: Department of Toxicology, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
authors: Cristina
authors: C
authors: Dehelean
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D045744:Cell Line, Tumor / Q000473:pathology*; D049109:Cell Proliferation; D017690:Cell Transplantation; D004195:Disease Models, Animal; D005260:Female; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A
keywords: B164A5; B16F10; B16FLT3; B16GMCSF; C57BL/6J