title: The MetaProteomeAnalyzer: a powerful open-source software suite for metaproteomics data analysis and interpretation.
abstract: The enormous challenges of mass spectrometry-based metaproteomics are primarily related to the analysis and interpretation of the acquired data. This includes reliable identification of mass spectra and the meaningful integration of taxonomic and functional meta-information from samples containing hundreds of unknown species. To ease these difficulties, we developed a dedicated software suite, the MetaProteomeAnalyzer, an intuitive open-source tool for metaproteomics data analysis and interpretation, which includes multiple search engines and the feature to decrease data redundancy by grouping protein hits to so-called meta-proteins. We also designed a graph database back-end for the MetaProteomeAnalyzer to allow seamless analysis of results. The functionality of the MetaProteomeAnalyzer is demonstrated using a sample of a microbial community taken from a biogas plant.
authors: Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany.
authors: Thilo
authors: T
authors: Muth
authors: Alexander
authors: A
authors: Behne
authors: Robert
authors: R
authors: Heyer
authors: Fabian
authors: F
authors: Kohrs
authors: Dirk
authors: D
authors: Benndorf
authors: Marcus
authors: M
authors: Hoffmann
authors: Miro
authors: M
authors: Lehtevä
authors: Udo
authors: U
authors: Reichl
authors: Lennart
authors: L
authors: Martens
authors: Erdmann
authors: E
authors: Rapp
mesh_terms: D003196:Computer Graphics; D013058:Mass Spectrometry; D020543:Proteome; D012984:Software
chemical_list: D020543:Proteome
keywords: bioinformatics; environmental proteomics; mass spectrometry; metaproteomics; microbial communities; software