title: [The influence of ouabagenin on the growth and proliferation of cells in the organotypical culture].
abstract: The aim of the present work was to investigate the effect of ouabagenin on the growth and proliferation of cells in organotypic culture. The objects of study were explants of nerve, cardiac, retina and liver tissue of 10-12 day old chicken embryos. Inhibitor of Na+,K(+)-ATPase ouabagenin was investigated in a wide range of concentrations (0.1 nM-1 mM). It has been found that the ouabagenin controls cell growth and proliferation in a dose-dependent manner and tissue-unspecific. The data obtained show that ouabagenin regulates only the pumping function of Na+,K(+)-ATPase.
authors: V A
authors: VA
authors: Penniiaĭnen
authors: A V
authors: AV
authors: Kipenko
authors: E V
authors: EV
authors: Lopatina
authors: B V
authors: BV
authors: Krylov
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017950:Ganglia, Sensory / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D009206:Myocardium / Q000166:cytology / Q000201:enzymology; D010042:Ouabain / Q000031:analogs & derivatives* / Q000494:pharmacology; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D004791:Enzyme Inhibitors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; C008721:ouabagenin