title: Pazopanib as first line treatment for solitary fibrous tumours: the Royal Marsden Hospital experience.
abstract: BACKGROUND
  Solitary Fibrous Tumour (SFT) is a rare soft tissue neoplasm, described in several locations in the body. It is classified as intermediate malignant potential with low risk of metastasis and has a low tendency to recur after primary surgery.
  
  
  METHODS
  We performed a prospective data collection of the patients with SFT presented to the Royal Marsden Hospital from January to December 2013, and treated with pazopanib in first line. Demographics, anatomic primary sites, treatment and survival outcomes were collected from patients' electronic records.
  
  
  RESULTS
  13 patients (54% females) were identified with a median age of 51 years (range 37-77). Most of the patients (77%) were diagnosed with extra-thoracic SFT. All the patients received first line treatment with pazopanib for metastatic disease. Median overall survival (OS) was 13.3 months. Median progression free survival (PFS) was 4.7 months. No statistically significant difference was found in OS and PFS between primary thoracic SFT and primary extra-thoracic SFT. According to RECIST, one partial response (9%) and eight disease stabilizations (73%) were found as best responses. Using Choi criteria, there were 5 partial responses (46%) and 4 stabilizations (36%).
  
  
  CONCLUSIONS
  Our prospective data confirm that anti-angiogenic drugs are active in SFT. PFS and overall response do not appear significantly lower than other reported series on the same disease. Furthermore, pazopanib is a drug already licensed in soft tissue sarcomas and these data suggest its activity also in this particular subtype of sarcomas.
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Marco
authors: M
authors: Maruzzo
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Juan
authors: J
authors: Martin-Liberal
authors: Radiology Department, The Royal Marsden NHS Foundation Trust, London, UK.
authors: Christina
authors: C
authors: Messiou
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Aisha
authors: A
authors: Miah
authors: Pathology Department, The Royal Marsden NHS Foundation Trust, London, UK.
authors: Khin
authors: K
authors: Thway
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Rolyn
authors: R
authors: Alvarado
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Ian
authors: I
authors: Judson
authors: Sarcoma Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, SW3 6JJ London, UK.
authors: Charlotte
authors: C
authors: Benson
keywords: Pazopanib; SFT; Sarcoma; Solitary fibrous tumour