title: Stereotactic body radiotherapy (SBRT) in the management of extracranial oligometastatic (OM) disease.
abstract: OBJECTIVE
  A review of stereotactic body radiotherapy (SBRT) for oligometastases defined as three or fewer sites of isolated metastatic disease. The aim was to identify local control, overall survival (OS) and progression-free survival (PFS) of patients receiving SBRT for oligometastatic (OM) disease.
  
  
  METHODS
  Data were analysed for SBRT delivered between 01 September 2010 and 31 March 2014. End points included local control, PFS, OS and toxicity.
  
  
  RESULTS
  76 patients received SBRT. The median age was 60 years (31-89 years). 44 were male. Median follow-up was 12.3 months (0.2-36.9 months). Major primary tumour sites included colorectal (38%), the breast (18%) and the prostate (12%). The treatment sites included lymph nodes (42%), the bone and spine (29%) and soft tissue (29%). 42% were previously treated with conventional radiotherapy. 45% were disease free after SBRT. 4% had local relapse, 45% had distant relapse, and 6% had local and distant relapse. Local control was 89%. The OS was 84.4% at 1 year and 63.2% at 2 years. PFS was 49.1% at 1 year and 26.2% at 2 years. Toxicities included duodenal ulcer and biliary stricture formation.
  
  
  CONCLUSIONS
  SBRT can achieve durable control of OM lesions and results in minimal radiation-induced morbidity.
  
  
  CONCLUSIONS
  This cohort is one of the largest reported to date and contributes to the field of SBRT in oligometastases that is emerging as an important research area. It is the only study reported from the UK and uses a uniform technique throughout. The efficacy and low toxicity with durable control of local disease with this approach is shown, setting the foundations for future randomized studies.
authors: Cyberknife Unit, Mount Vernon Cancer Centre, Northwood, UK.
authors: I S
authors: IS
authors: Bhattacharya
authors: D K
authors: DK
authors: Woolf
authors: R J
authors: RJ
authors: Hughes
authors: N
authors: N
authors: Shah
authors: M
authors: M
authors: Harrison
authors: P J
authors: PJ
authors: Ostler
authors: P J
authors: PJ
authors: Hoskin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D015996:Survival Rate; D016896:Treatment Outcome