title: Two-year incidence of psoriasis, uveitis and inflammatory bowel disease in patients with spondyloarthritis: A study in the AQUILES cohort.
abstract: OBJECTIVE
  To describe the 2-year incidence of new extra-articular manifestations (uveitis, psoriasis, inflammatory bowel disease) in a cohort of patients with spondyloarthritis included in the AQUILES study.
  
  
  METHODS
  Over a period of 2 years, 513 patients with spondyloarthritis (62.5% males, mean age 48 years) diagnosed with ankylosing spondylitis (AS) (55.6%), psoriatic arthritis (25.3%), undifferentiated spondyloarthritis (16.2%), enteropathic arthritis (2.5%), and other diseases (0.4%) were followed. New diagnoses were based on reports of the corresponding specialists (ophthalmologists, dermatologists, gastroenterologists).
  
  
  RESULTS
  During the 2-year follow-up, 22 new diagnoses of the extra-articular manifestations were established, with a cumulative incidence of 4.3% (95% confidence interval 2.4-6.1) and an incidence rate of 17 cases per 10,000 patient-year. Uveitis was the most frequent diagnosis (cumulative incidence 3.1%), predominantly in patients with AS. In the multivariate analysis, the diagnosis of AS was the only predictive variable associated to the development of new extra-articular disease.
  
  
  CONCLUSIONS
  In patients with spondyloarthritis, the 2-year global incidence of uveitis, psoriasis and inflammatory bowel disease (IMID) was 4.3%, particularly due to new diagnoses of uveitis in patients with AS.
authors: Departamento de Reumatología, Hospital Universitario La Princesa, IIS-IP, Madrid, España. Electronic address: vicuna111@gmail.com.
authors: Rosario
authors: R
authors: García-Vicuña
authors: Departamento de Reumatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.
authors: Pedro
authors: P
authors: Zarco
authors: Departamento de Reumatología, Hospital Universitario Gregorio Marañón, Madrid, España.
authors: Carlos M
authors: CM
authors: González
authors: Departamento de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España.
authors: Francisco
authors: F
authors: Vanaclocha
authors: Departamento de Gastroenterología, Hospital Universitario Gregorio Marañón, Madrid, España.
authors: Ignacio
authors: I
authors: Marín-Jiménez
authors: Departamento de Medical Affairs, Merck Sharp & Dohme de España, S. A., Madrid, España.
authors: Luis
authors: L
authors: Cea-Calvo
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D011565:Psoriasis / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D013030:Spain; D025241:Spondylarthritis / Q000150:complications*; D014605:Uveitis / Q000453:epidemiology / Q000209:etiology*
keywords: Ankylosing spondylitis; Artritis psoriásica; Enfermedad inflamatoria intestinal; Espondilitis anquilosante; Espondiloartritis; Estudio observacional; Estudio prospectivo; Inflammatory bowel disease; Observational study; Prospective study; Psoriatic arthritis; Spondyloarthritis; Uveitis; Uveítis