title: Properties of the tibialis anterior muscle after treatment with laser therapy and natural latex protein following sciatic nerve crush.
abstract: BACKGROUND
  In this study we evaluated the characteristics of the tibialis anterior muscle after sciatic nerve crush and treatment with low-level laser therapy (LLLT) or the protein from natural latex (P1).
  
  
  METHODS
  We studied the following 6 groups of male Wistar rats: control (CG); exposed nerve (EG); injured nerve (IG); injured nerve with LLLT (LG); injured nerve with P1 (PG); and injured nerve with P1 and LLLT (LPG).
  
  
  RESULTS
  After 4 weeks, muscle morphology showed improvement in the treated groups; after 8 weeks, the treated groups resembled controls, especially the PG. Morphometry revealed muscle fiber atrophy after nerve injury, with time-dependent recovery. Histochemical analysis revealed increased intermediate fiber area. The PG was more similar to controls with NADH staining, whereas the LPG more closely resembled controls with SDH staining.
  
  
  CONCLUSIONS
  Treatment using only P1 proved most efficient, revealing a negative interaction between P1 and LLLT.
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Kenia Lemos
authors: KL
authors: Muniz
authors: Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.|Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Fernando José
authors: FJ
authors: Dias
authors: Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Joaquim
authors: J
authors: Coutinho-Netto
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Ricardo Alexandre Junqueira
authors: RA
authors: Calzzani
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Mamie Mizusaki
authors: MM
authors: Iyomasa
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Luiz Gustavo De
authors: LG
authors: Sousa
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Thais Tedeschi Dos
authors: TT
authors: Santos
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Vanessa De Oliveira
authors: Vde O
authors: Teles
authors: Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors: Ii-Sei
authors: IS
authors: Watanabe
authors: Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: Valéria Paula Sassoli
authors: VP
authors: Fazan
authors: Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil.
authors: João Paulo Mardegan
authors: JP
authors: Issa
mesh_terms: D000818:Animals; D028482:Hevea; D053685:Laser Therapy / Q000379:methods*; D007840:Latex / Q000302:isolation & purification / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods; D008297:Male; D009409:Nerve Crush; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007840:Latex
keywords: laser therapy; metabolism; morphology; muscle; natural latex protein; nerve crush