title: Adipose-derived mesenchymal stem cells reduce MMP-1 expression in UV-irradiated human dermal fibroblasts: therapeutic potential in skin wrinkling.
abstract: Adipose-derived mesenchymal stem cells (AdMSCs) have been reported to have therapeutic benefit in skin. The aim of this study was to examine the effects of AdMSCs in UV-irradiated human dermal fibroblasts (HDFs) for therapeutic potential in skin wrinkling. UV irradiation, a model naturally mimic skin wrinkle formation, is known to increase matrix metalloproteinase-1 (MMP-1), making MMP-1 a target for skin photoaging. Our findings identified that AdMSCs reduce MMP-1 level in UV-irradiated HDFs and increase type 1 procollagen in HDFs. A dose-dependent increase in type 1 procollagen was confirmed by AdMSC-conditioned medium. Importantly, our current findings showing the effects of AdMSCs on the induction of MMP-1 in UV-radiated HDFs and the expression of collagen in HDFs can provide an evidence of relationship between MMP-1 and procollagen production for the protection against wrinkle formation. Collectively, AdMSCs may contribute to anti-wrinkle effects in skin but further experiments are needed to identify the mechanism.
authors: a Department of Pathology , University of Ulsan College of Medicine, Asan Medical Center , Seoul , Republic of Korea.
authors: Woo-Chan
authors: WC
authors: Son
authors: Jun-Won
authors: JW
authors: Yun
authors: Bae-Hwan
authors: BH
authors: Kim
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D049109:Cell Proliferation / Q000528:radiation effects; D018920:Coculture Techniques; D024042:Collagen Type I / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism* / Q000528:radiation effects; D015971:Gene Expression Regulation, Enzymologic / Q000528:radiation effects*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D011347:Procollagen / Q000378:metabolism; D012867:Skin / Q000166:cytology* / Q000528:radiation effects; D015595:Skin Aging / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D024042:Collagen Type I; D017077:Culture Media, Conditioned; D016207:Cytokines; D011347:Procollagen; D020781:Matrix Metalloproteinase 1
keywords: AdMSCs; HDFs; MMP-1; anti-wrinkle; procollagen