title: Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity.
abstract: A new, simple thermally efficient and solvent-free condensation of 2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives with coumarin-3-carboxylic acid employing pentafluorophenylammonium triflate (PFPAT) as an inexpensive organocatalyst for the synthesis of a series of ethyl 4,5-dihydro 7-methyl-2-(2-oxo-2H-chromen-3-yl)-4-oxo-5-aryl-3H-chromeno[2,3-d]pyrimidine-6-carboxylate derivatives is described. This method has the advantages of high yields, a cleaner reaction, simple methodology, short reaction times, easy workup, and greener conditions. All the compounds were evaluated for their in vitro antimicrobial activity against different bacterial and fungal strains.
authors: Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran.
authors: Majid
authors: M
authors: Ghashang
authors: Research Department of Chemistry, Bioactive Organic Molecule Synthetic Unit, C. Abdul Hakeem College, Melvisharam 632 509, Tamil Nadu, India.
authors: Syed Sheik
authors: SS
authors: Mansoor
authors: Research Department of Chemistry, Bioactive Organic Molecule Synthetic Unit, C. Abdul Hakeem College, Melvisharam 632 509, Tamil Nadu, India.
authors: Krishnamoorthy
authors: K
authors: Aswin
keywords: 2-Amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate; Antimicrobial activity; Chromeno[2,3-d]pyrimidinones; Coumarin-3-carboxylic acid; Pentafluorophenylammonium triflate