title: Increased likelihood of post-polycythemia vera myelofibrosis in Ph-negative MPN patients with chromosome 12 abnormalities.
abstract: Chromosome 12 (Chr12) abnormalities have been described for individual patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-neg MPN), however the frequency, characteristics, and outcomes of such patients as a whole have not been investigated. We reviewed a database of 1787 consecutive Ph-neg MPN patients seen at our institution and determined that 2% of Ph-neg MPN patients harbored an alteration involving Chr12 by cytogenetic evaluation. Retrospective chart review revealed that patients with Chr12 abnormalities had a higher likelihood of having myelofibrosis (MF) compared to patients without a Chr12 abnormality, and were more likely to have post-polycythemia vera MF. The most common alterations in Chr12 in MF patients involved 12q13, 12q15, 12q24, and trisomy 12, and >40% of Chr12 Ph-neg MPN patients had cytogenetic evolution. Chr12 abnormalities did not significantly correlate with JAK2 status, progression to acute myeloid leukemia, or survival, however patients with 12q24 abnormalities trended toward poorer outcomes.
authors: Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Christopher B
authors: CB
authors: Benton
authors: Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
authors: Maria
authors: M
authors: Tanaka
authors: Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
authors: Catherine
authors: C
authors: Wilson
authors: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Sherry
authors: S
authors: Pierce
authors: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Lingsha
authors: L
authors: Zhou
authors: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Jorge
authors: J
authors: Cortes
authors: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Hagop
authors: H
authors: Kantarjian
authors: Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. Electronic address: sverstov@mdanderson.org.
authors: Srdan
authors: S
authors: Verstovsek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics / Q000401:mortality; D009367:Neoplasm Staging; D010677:Philadelphia Chromosome; D011087:Polycythemia Vera / Q000209:etiology* / Q000401:mortality; D055728:Primary Myelofibrosis / Q000209:etiology* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: Chromosome aberrations; Myelofibrosis; Myeloproliferative neoplasms; Polycythemia vera