title: Simultaneous induction of axial and planar chirality in arene-chromium complexes by molybdenum-catalyzed enantioselective ring-closing metathesis.
abstract: The molybdenum-catalyzed asymmetric ring-closing metathesis of the various Cs -symmetric (π-arene)chromium substrates provides the corresponding bridged planar-chiral (π-arene)chromium complexes in excellent yields with up to >99 % ee. With a bulky and unsymmetrical substituent, such as N-indolyl or 1-naphthyl, at the 2-positions of the η(6) -1,3-diisopropenylbenzene ligands, both biaryl-based axial chirality and π-arene-based planar chirality are simultaneously induced in the products. The axial chirality is retained even after the removal of the dicarbonylchromium fragment, and the chiral biaryl/heterobiaryl compounds are obtained with complete retention of the enantiopurity.
authors: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan), Fax: (+81) 72-254-9931. kamikawa@c.s.osakafu-u.ac.jp.
authors: Ken
authors: K
authors: Kamikawa
authors: Sachie
authors: S
authors: Arae
authors: Wei-Yi
authors: WY
authors: Wu
authors: Chihiro
authors: C
authors: Nakamura
authors: Tamotsu
authors: T
authors: Takahashi
authors: Masamichi
authors: M
authors: Ogasawara
keywords: asymmetric synthesis; chromium; desymmetrization; metathesis; molybdenum