title: Accelerated epigenetic aging in Down syndrome.
abstract: Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(-14)).
authors: Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA; Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA.
authors: Steve
authors: S
authors: Horvath
authors: Paolo
authors: P
authors: Garagnani
authors: Maria Giulia
authors: MG
authors: Bacalini
authors: Chiara
authors: C
authors: Pirazzini
authors: Stefano
authors: S
authors: Salvioli
authors: Davide
authors: D
authors: Gentilini
authors: Anna Maria
authors: AM
authors: Di Blasio
authors: Cristina
authors: C
authors: Giuliani
authors: Spencer
authors: S
authors: Tung
authors: Harry V
authors: HV
authors: Vinters
authors: Claudio
authors: C
authors: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics; D015415:Biomarkers / Q000032:analysis; D019175:DNA Methylation / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods; D006801:Humans; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: DNA methylation; Down syndrome; biomarker of aging; epigenetics