title: Antagonist of prostaglandin E2 receptor 4 induces metabolic alterations in liver of mice.
abstract: Prostaglandin E2 receptor 4 (EP4) is one of the receptors for prostaglandin E2 and plays important roles in various biological functions. EP4 antagonists have been used as anti-inflammatory drugs. To investigate the effects of an EP4 antagonist (L-161982) on the endogenous metabolism in a holistic manner, we employed a mouse model, and obtained metabolic and transcriptomic profiles of multiple biological matrixes, including serum, liver, and urine of mice with and without EP4 antagonist (L-161982) exposure. We found that this EP4 antagonist caused significant changes in fatty acid metabolism, choline metabolism, and nucleotide metabolism. EP4 antagonist exposure also induced oxidative stress to mice. Our research is the first of its kind to report information on the alteration of metabolism associated with an EP4 antagonist. This information could further our understanding of current and new biological functions of EP4.
authors: Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, University of Chinese Academy of Sciences , Wuhan, 430071, P. R. China.
authors: Ning
authors: N
authors: Li
authors: Limin
authors: L
authors: Zhang
authors: Yanpeng
authors: Y
authors: An
authors: Lulu
authors: L
authors: Zhang
authors: Yipeng
authors: Y
authors: Song
authors: Yulan
authors: Y
authors: Wang
authors: Huiru
authors: H
authors: Tang
mesh_terms: D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D066244:Proton Magnetic Resonance Spectroscopy; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000037:antagonists & inhibitors*; D013876:Thiophenes / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: C508711:L-161982; D058309:Receptors, Prostaglandin E, EP4 Subtype; D013876:Thiophenes; D014230:Triazoles
keywords: L-161982; NMR; metabonomics; prostaglandin E2 receptor 4; transcriptomics