title: Glucose control positively influences patient outcome: A retrospective study.
abstract: OBJECTIVE
  The goal of this research is to demonstrate that well-regulated glycemia is beneficial to patient outcome, regardless of how it is achieved.
  
  
  METHODS
  This analysis used data from 1701 patients from 2, independent studies. Glycemic outcome was measured using cumulative time in band (cTIB), calculated for 3 glycemic bands and for threshold values of t = 0.5, 0.6, 0.7, and 0.8. For each day of intensive care unit stay, patients were classified by cTIB, threshold, and hospital mortality, and odds of living (OL) and odds ratio were calculated.
  
  
  RESULTS
  The OL given cTIB ≥ t is higher than the OL given cTIB <t for all values of t, every day, for all 3 glycemic bands studied. The difference between the odds clearly increased over intensive care unit stay for t>0.6. Higher cTIB thresholds resulted in larger increases to odds ratio over time and were particularly significant for the 4.0 to 7.0 mmol/L glycemic band.
  
  
  CONCLUSIONS
  Increased cTIB was associated with higher OL. These results suggest that effective glycemic control positively influences patient outcome, regardless of how the glycemic regulation is achieved. Blood glucose < 7.0 mmol/L is associated with a measurable increase in the odds of survival, if hypoglycemia is avoided.
authors: GIGA-Cardiovascular Sciences, Institut de Physique, Université de Liege, Institut de Physics, Allée du 6 Août, 17 (Bât B5), B4000 Liege, Liege, Belgium. Electronic address: Sophie.Penning@ulg.ac.be.
authors: Sophie
authors: S
authors: Penning
authors: Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Private Bag 4800, Christchurch 8054, New Zealand. Electronic address: chris.pretty@canterbury.ac.nz.
authors: Chris
authors: C
authors: Pretty
authors: Department of Intensive Care, Erasme University Hospital, 808 route de Lennik, B1070 Brussels, Belgium. Electronic address: Jean-Charles.Preiser@erasme.ulb.ac.be.
authors: Jean-Charles
authors: JC
authors: Preiser
authors: School of Medicine, University of Otago Christchurch, Christchurch 8054, New Zealand; Department of Intensive Care, Christchurch Hospital, Christchurch 8054, New Zealand. Electronic address: geoff.shaw@cdhb.govt.nz.
authors: Geoffrey M
authors: GM
authors: Shaw
authors: GIGA-Cardiovascular Sciences, Institut de Physique, Université de Liege, Institut de Physics, Allée du 6 Août, 17 (Bât B5), B4000 Liege, Liege, Belgium. Electronic address: tdesaive@ulg.ac.be.
authors: Thomas
authors: T
authors: Desaive
authors: Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Private Bag 4800, Christchurch 8054, New Zealand. Electronic address: geoff.chase@canterbury.ac.nz.
authors: J Geoffrey
authors: JG
authors: Chase
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003422:Critical Care; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007003:Hypoglycemia / Q000517:prevention & control; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose
keywords: Critical care; Critically ill patients; Glycemia; Glycemic control; Mortality; Patient outcome