title: Flaxseed oil reduces oxidative stress and enhances brain monoamines release in streptozotocin-induced diabetic rats.
abstract: This study was performed to investigate the biochemical effect of flaxseed oil on oxidative stress and brain monoamines release in streptozotocin-induced diabetic rats. Sixty male albino rats were divided into following four groups (15 for each group): control group, flaxseed oil group, diabetic group, and flaxseed oil-treated diabetic group. Serum glucose, insulin, pentosidine, plasma advanced oxidation protein products (AOPPs), and plasma total antioxidant capacity were estimated. Brain neurotransmitters, malondialdehyde (MDA), and nitric oxide (NO) were also determined. The mean values of serum pentosidine and plasma AOPP showed a significant decrease in treated diabetic group as compared to their values in the diabetic group. Also, brain neurotransmitters levels were improved after treatment with flaxseed. Brain MDA and NO were increased significantly in the diabetic group, while they were significantly decreased after treatment. Brain NO and brain MDA had a significant positive correlation with pentosidine, AOPP, and neurotransmitters. We concluded that flaxseed oil supplementation may be useful in the treatment of brain dysfunction in diabetes.
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: E A
authors: EA
authors: Badawy
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: W I
authors: WI
authors: Rasheed
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt tahany_adel@hotmail.com.
authors: T R
authors: TR
authors: Elias
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: J
authors: J
authors: Hussein
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: M
authors: M
authors: Harvi
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: S
authors: S
authors: Morsy
authors: Department of Medical Biochemistry, National Research Center, Doki, Giza, Egypt.
authors: Ya El-Latif
authors: Yel-L
authors: Mahmoud
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D019587:Dietary Supplements; D004298:Dopamine / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008043:Linseed Oil / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009569:Nitric Oxide; D012701:Serotonin; D008315:Malondialdehyde; D008043:Linseed Oil; D004298:Dopamine; D009638:Norepinephrine
keywords: Flaxseed oil; brain monoamines; diabetes; oxidative stress