title: Risk factors for rehospitalization for acute coronary syndromes and unplanned revascularization following acute myocardial infarction.
abstract: BACKGROUND
  Rehospitalizations for acute coronary syndromes (ACS) and coronary revascularization after an acute myocardial infarction (AMI) are not only common and costly but can also impact patients' quality of life. In contrast to mortality and all-cause readmissions, little insight is available into risk factors associated with ACS and revascularization after AMI.
  
  
  RESULTS
  In a multicenter AMI registry, we examined the rates and predictors of rehospitalizations for ACS and revascularization within the year after AMI among 3283 patients. Staged revascularization procedures were excluded. Kaplan-Meier estimated rates of rehospitalization due to ACS and revascularization were 6.8% and 4.1%, respectively. In hierarchical, multivariable models, the strongest predictors of rehospitalization for ACS were coronary artery bypass graft prior to AMI hospitalization (hazard ratio [HR] 2.12, 95% CI 1.45 to 3.10), female sex (HR 1.67, 95% CI 1.23 to 2.25), and in-hospital PCI (HR 1.85, 95% CI 1.28 to 2.69). The strongest predictors of subsequent revascularization were multivessel disease (HR 2.89, 95% CI 1.90 to 4.39) and in-hospital percutaneous coronary intervention with a bare metal stent (HR 2.08, 95% CI 1.19 to 3.63). The Global Registry of Acute Coronary Events mortality risk score was not associated with the risk of rehospitalization for ACS or revascularization.
  
  
  CONCLUSIONS
  Unique characteristics are associated with admissions for ACS and revascularization, as compared with survival. These multivariable risk predictors may help identify patients at high risk for ACS and revascularization, in whom intensification of secondary prevention therapies or closer post-AMI follow-up may be warranted.
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.) University of Missouri-Kansas City, Kansas City, MO (S.V.A., K.G.S., J.A.S.).
authors: Suzanne V
authors: SV
authors: Arnold
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.) University of Missouri-Kansas City, Kansas City, MO (S.V.A., K.G.S., J.A.S.).
authors: Kim G
authors: KG
authors: Smolderen
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.).
authors: Kevin F
authors: KF
authors: Kennedy
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.).
authors: Yan
authors: Y
authors: Li
authors: Emory School of Medicine, Atlanta, GA (S.S.).
authors: Supriya
authors: S
authors: Shore
authors: Saint Louis University, St Louis, MO (J.M.S.).
authors: Joshua M
authors: JM
authors: Stolker
authors: Duke Clinical Research Institute, Durham, NC (T.Y.W.).
authors: Tracy Y
authors: TY
authors: Wang
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.).
authors: Philip G
authors: PG
authors: Jones
authors: Eli Lilly and Company, Indianapolis, IN (Z.Z.).
authors: Zhenxiang
authors: Z
authors: Zhao
authors: Saint Luke's Mid America Heart Institute, Kansas City, MO (S.V.A., K.G.S., K.F.K., Y.L., P.G.J., J.A.S.) University of Missouri-Kansas City, Kansas City, MO (S.V.A., K.G.S., J.A.S.).
authors: John A
authors: JA
authors: Spertus
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology / Q000628:therapy*; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery / Q000628:therapy*; D009204:Myocardial Revascularization / Q000706:statistics & numerical data*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011788:Quality of Life; D012307:Risk Factors; D012737:Sex Factors; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome
keywords: myocardial infarction; rehospitalization; revascularization; unstable angina