title: [The role of oxidative damage of proteins and lipids in pathogenesis of traumatic disease in severe combined thoracic trauma].
abstract: The investigation objective was to study the dynamics of indices of the lipids and proteins oxidative damage, as well as search for possible prognostic criteria in the injured persons with severe combined thoracic trauma. Concentration of carbonyl groups of proteins and malonic dialdehyde was determined on 1-2d, 3-4th and 5-6th day after trauma in the blood plasm of 73 patients, ageing 20 -68 yrs old. While in conditions of massive infusion therapy concentration of the indices investigated do not reflect the oxidative processes intensity. Relative concentration in recalculation on concentration of common protein content constitutes a more demonstratable index. On the 5-6th day after trauma a tendency for normalization of the oxidative damage of lipids and proteins indices was observed in the patients, who have recovered, and while lethal outcome--their further enhancement was noted. There was established a one-direction dynamics of a relative indices in both groups up to 3-4-th day after trauma with a step-by-step its enhancement. Concentration of carbonyl groups of proteins more than 15.86 mcmol/g of protein on the 5-6-th day after trauma ought to be considered a trustworthy criterion of unfavorable prognosis.
authors: M A
authors: MA
authors: Stupnyts'kyĭ
authors: V I
authors: VI
authors: Zhukov
authors: T V
authors: TV
authors: Horbach
authors: A Iu
authors: AIu
authors: Pavlenko
authors: O V
authors: OV
authors: Bilets'kyĭ
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D011379:Prognosis; D050050:Protein Carbonylation; D012306:Risk; D016019:Survival Analysis; D013898:Thoracic Injuries / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015599:Trauma Severity Indices
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008055:Lipids; D008315:Malondialdehyde