title: Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.
abstract: Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.
authors: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.
authors: Wolfgang
authors: W
authors: Hohenforst-Schmidt
authors: 2. Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Paul
authors: P
authors: Zarogoulidis
authors: 3. Covidien, U.S.A.
authors: Joshua
authors: J
authors: Stopek
authors: 4. Veterinary School, Aristotle University of Thessaloniki, Greece.
authors: Efstratios
authors: E
authors: Kosmidis
authors: 5. Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Frankfurt, Germany.
authors: Thomas
authors: T
authors: Vogl
authors: 6. Department of Thoracic Surgery, Medinos Clinic Sonneberg, Sonnerberg, Germany.
authors: Bernd
authors: B
authors: Linsmeier
authors: 7. Department of Thoracic Surgery,"Saint Luke" Private Hospital, Panorama, Thessaloniki, Greece.
authors: Kosmas
authors: K
authors: Tsakiridis
authors: 2. Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Sofia
authors: S
authors: Lampaki
authors: 8. Oncology Department, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: George
authors: G
authors: Lazaridis
authors: 7. Department of Thoracic Surgery,"Saint Luke" Private Hospital, Panorama, Thessaloniki, Greece.
authors: Andreas
authors: A
authors: Mpakas
authors: 9. Pulmonary & Critical Care Medicine, Interventional Pulmonology, National Naval Medical Center, Walter Reed Army Medical Center, Bethesda, U.S.A.
authors: Robert
authors: R
authors: Browning
authors: 2. Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Antonis
authors: A
authors: Papaiwannou
authors: 10. Radiology Department, "Interbalkan European Medical Center", Τhessaloniki. Greece.
authors: Antonis
authors: A
authors: Drevelegas
authors: 11. Oncology Department, "Interbalkan European Medical Center", Τhessaloniki. Greece.
authors: Sofia
authors: S
authors: Baka
authors: 8. Oncology Department, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Vasilis
authors: V
authors: Karavasilis
authors: 12. Oncology Department, "BioMedicine" Clinic, Thessaloniki, Greece.
authors: Ioannis
authors: I
authors: Mpoukovinas
authors: 13. Division of Interventional Pulmonology & 2 Medical Oncology, Cancer Treatment Centers of America, Western Regional Medical Center, Goodyear, AZ.
authors: J Francis
authors: JF
authors: Turner
authors: 2. Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Konstantinos
authors: K
authors: Zarogoulidis
authors: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.
authors: Johannes
authors: J
authors: Brachmann
keywords: cisplatin; intratumoral; lipiodol; lung cancer; microwave ablation