title: [Development of disease modifying drugs for dementia-focusing on anti-tau drugs-].
abstract: In an aging society, the number of people with dementia has increased. Since Alzheimer's disease and a part of frontotemporal lober degeneration (FTLD-tau) have abnormal tau pathology in brain, these are called Tauopathy. Previously results showed that occurrence of abnormal tau has been involved in development of cognitive dysfunction and neuronal loss indicating that tau-focused drug (inhibitors of tau hyperphosphorylation, tau aggregation and so on) may be valuable in therapy for Tauopathy. This study collated data of clinical trials that evaluated tau-based drugs to help development of agent for dementia drugs in future. We discovered a novel tau aggregation inhibitor, and elucidated the inhibitory mechanism of the compound on tau aggregation. These results suggest that tau aggregation is an important target for therapy of dementia.
authors: Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology.
authors: Yoshiyuki
authors: Y
authors: Soeda
authors: Akihiko
authors: A
authors: Takashima
mesh_terms: D002986:Clinical Trials as Topic; D003704:Dementia / Q000188:drug therapy* / Q000209:etiology*; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D058990:Molecular Targeted Therapy; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D066263:Protein Aggregation, Pathological; D016875:tau Proteins
chemical_list: D018697:Nootropic Agents; D016875:tau Proteins