title: Translationally controlled tumor protein in prostatic adenocarcinoma: correlation with tumor grading and treatment-related changes.
abstract: Prostate cancer is the second leading cause of cancer-related death. The androgen deprivation therapy is the standard treatment for advanced stages. Unfortunately, virtually all tumors become resistant to androgen withdrawal. The progression to castration-resistance is not fully understood, although a recent paper has suggested translationally controlled tumor protein to be implicated in the process. The present study was designed to investigate the role of this protein in prostate cancer, focusing on the correlation between its expression level with tumor differentiation and response to treatment. We retrieved 292 prostatic cancer specimens; of these 153 had been treated only by radical prostatectomy and 139 had undergone radical prostatectomy after neoadjuvant treatment with combined androgen blockade therapy. Non-neoplastic controls were represented by 102 prostatic peripheral zone specimens. In untreated patients, the expression of the protein, evaluated by RT-qPCR and immunohistochemistry, was significantly higher in tumor specimens than in non-neoplastic control, increasing as Gleason pattern and score progressed. In treated prostates, the staining was correlated with the response to treatment. An association between protein expression and the main clinicopathological factors involved in prostate cancer aggressiveness was identified. These findings suggest that the protein may be a promising prognostic factor and a target for therapy.
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy ; Section of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Piazzale Borella 1, 21047 Saronno, Italy.
authors: Bruno Jim
authors: BJ
authors: Rocca
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Alessandro
authors: A
authors: Ginori
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Aurora
authors: A
authors: Barone
authors: Section of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Piazzale Borella 1, 21047 Saronno, Italy.
authors: Calogera
authors: C
authors: Calandra
authors: Section of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Piazzale Borella 1, 21047 Saronno, Italy.
authors: Filippo
authors: F
authors: Crivelli
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy ; School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, E14NS London, UK.
authors: Giulia
authors: G
authors: De Falco
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Sara
authors: S
authors: Gazaneo
authors: Section of Pathology, Azienda Ospedaliera Universitaria Senese, Viale Bracci 16, 53100 Siena, Italy.
authors: Sergio
authors: S
authors: Tripodi
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Gabriele
authors: G
authors: Cevenini
authors: Department of Medicine, Science and Neurosciences, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Maria Teresa
authors: MT
authors: del Vecchio
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Maria Raffaella
authors: MR
authors: Ambrosio
authors: Section of Pathology, Department of Medical Biotechnology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy.
authors: Piero
authors: P
authors: Tosi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D000728:Androgens / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D060787:Neoplasm Grading / Q000379:methods; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D000090324:Tumor Protein, Translationally-Controlled 1
chemical_list: D000728:Androgens; D014408:Biomarkers, Tumor; D000090324:Tumor Protein, Translationally-Controlled 1