title: Microbial-assisted synthesis and evaluation the cytotoxic effect of tellurium nanorods.
abstract: The present study was designed to isolate bacterial strain capable of tellurium nanorods' (Te NRs) production followed by purification and evaluation of the cytotoxic effect of Te NRs. Among 25 environmental samples collected for screening of Te NR-producer bacterial strains one bacterial colony (isolated from hot spring and identified as Pseudomonas pseudoalcaligenes strain Te) was selected and applied for biosynthesis of Te NRs. Thereafter, an organic-aqueous partitioning system was applied for the purification of the biogenic Te NRs and the purified Te NRs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction spectroscopy (XRD), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. The cytotoxic effect of biologically synthesized Te NRs and potassium tellurite on four cell lines of MCF-7, HT1080, HepG2 and A549 was then determined using the MTT assay method. The obtained results revealed lower toxicity for the rod-shaped biogenic tellurium nanostructures (~22nm diameter by 185nm length) compared to K2TeO3.
authors: Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors: Hamid
authors: H
authors: Forootanfar
authors: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
authors: Sahar
authors: S
authors: Amirpour-Rostami
authors: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
authors: Mandana
authors: M
authors: Jafari
authors: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Amir
authors: A
authors: Forootanfar
authors: The Student Research Committee, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
authors: Zahra
authors: Z
authors: Yousefizadeh
authors: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: shakiba@kmu.ac.ir.
authors: Mojtaba
authors: M
authors: Shakibaie
mesh_terms: D008854:Microscopy, Electron / Q000379:methods; D043942:Nanotubes; D011549:Pseudomonas / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D013691:Tellurium / Q000737:chemistry*
chemical_list: D013691:Tellurium
keywords: Biosynthesis; Cytotoxicity; Potassium tellurite; Pseudomonas pseudoalcaligenes; Tellurium nanorods