title: TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis.
abstract: Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.
authors: Laboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Yingshui
authors: Y
authors: Yao
authors: School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Xiaohua
authors: X
authors: Ren
authors: School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Lianping
authors: L
authors: He
authors: School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Jie
authors: J
authors: Li
authors: School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Yuelong
authors: Y
authors: Jin
authors: School of Public Health, Wannan Medical College Wuhu 241002, China.
authors: Weiwei
authors: W
authors: Chang
authors: Laboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; Department of Medical Parasitology, Wannan Medical College Wuhu 241002, China.
authors: Chaopin
authors: C
authors: Li
keywords: Toll-Like Receptor 4; asthma; meta-analysis; polymorphism; single nucleotide polymorphism