title: Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding.
abstract: BACKGROUND
  This experimental study compared the hemostatic effects of calcium alginate and Anka-ferd Blood Stopper in hepatic parenchymal bleedings.
  
  
  METHODS
  The study comprised 39 male Wistar albino rats (weight 230±30 g). Laceration model was created in the left lateral lobe of the liver. Standard cotton gauze that was impregnated 0.9% NaCl solution and Calcium alginate cover was compared to ABS tampon. The amount of preoperative bleeding, preoperative and postoperative Day 1 hematocrit levels, and the difference between them were assessed and statistically analyzed.
  
  
  RESULTS
  Comparing the hematocrit levels between the groups, we found that the amount of bleeding was significantly higher in the control group versus the study groups (p<0.001). Histopathological examination revealed the portal area enlargement and biliary canaliculi proliferation. In the Ca2+ Alginate group, it was observed that the fibres were still present in the incision line with massive fibrotic area around. In the Ankaferd group, examination of the preparations revealed patchy focal necrosis areas but no fibrotic area.
  
  
  CONCLUSIONS
  With this study, we demonstrated that both calcium alginate and Ankaferd have hemostatic effect in preventing hepatic parenchymal bleeding and that calcium alginate causes fibrosis in the liver, where ABS causes focal necrosis areas(Tab. 2, Fig. 4, Ref. 19).
authors: O
authors: O
authors: Aydin
authors: S
authors: S
authors: Tuncal
authors: B
authors: B
authors: Kilicoglu
authors: A K
authors: AK
authors: Onalan
authors: M A
authors: MA
authors: Gonultas
authors: H
authors: H
authors: Ozer
authors: A
authors: A
authors: Durhan
authors: V
authors: V
authors: Tasova
authors: S
authors: S
authors: Hucumenoglu
authors: K
authors: K
authors: Kismet
mesh_terms: D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001760:Bleeding Time; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004195:Disease Models, Animal; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000517:prevention & control*; D020723:Glucuronic Acid / Q000494:pharmacology; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D006603:Hexuronic Acids / Q000494:pharmacology; D008099:Liver / Q000293:injuries*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000464:Alginates; D006490:Hemostatics; D006603:Hexuronic Acids; D010936:Plant Extracts; C539751:ankaferd blood stopper; D020723:Glucuronic Acid