title: Cascade arylalkylation of activated alkenes: synthesis of chloro- and cyano-containing oxindoles.
abstract: The general method for the oxidative cyclization of arylacrylamides with dichloromethane or acetonitrile has been developed. The reactions described provide novel access to chloro- and cyano-containing oxindoles in good to moderate yields that allow the direct formation of a C-C bond and the construction of an oxindole ring in one reaction. The use of a cheap and easily prepared Mn(OAc)3 represents an added advantage of this method.
authors: Department of Chemistry, College of Chemistry and Chemical Engineering, and Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
authors: Xueqin
authors: X
authors: Li
authors: Jian
authors: J
authors: Xu
authors: Yuzhen
authors: Y
authors: Gao
authors: Hua
authors: H
authors: Fang
authors: Guo
authors: G
authors: Tang
authors: Yufen
authors: Y
authors: Zhao
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000085:Acetates; D000097:Acetonitriles; D000475:Alkenes; D007211:Indoles; D009942:Organometallic Compounds; D000078183:Oxindoles; D013141:Spiro Compounds; C521134:manganese(III) acetate dihydrate; C022960:2-oxindole; C032159:acetonitrile