title: A rare case of HPV-negative cervical squamous cell carcinoma.
abstract: It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.
authors: Departments of Pathology (S.C., W.G.M.) Gynaecological Oncology (I.H.), Belfast Health and Social Care Trust, Belfast Department of Molecular Pathology (J.J.), Antrim Area Hospital, Northern Ireland DDL Diagnostic Laboratory (A.M., H.V.D.M.), Rijswijk, The Netherlands.
authors: Shauna
authors: S
authors: Casey
authors: Ian
authors: I
authors: Harley
authors: Jackie
authors: J
authors: Jamison
authors: Anco
authors: A
authors: Molijn
authors: Henk
authors: H
authors: van den Munckhof
authors: W Glenn
authors: WG
authors: McCluggage
mesh_terms: D052685:Alphapapillomavirus / Q000302:isolation & purification; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology*