title: DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; synthesis, spectral characterization.
abstract: Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies [infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like [M(AMTA)2], [M(ATA)2] type, where M=Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium.
authors: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India. Electronic address: kumarnaikinorg@gmail.com.
authors: K H
authors: KH
authors: Kumar Naik
authors: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India. Electronic address: ashokbassanna@gmail.com.
authors: B
authors: B
authors: Ashok
authors: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India. Electronic address: drnaikchem@gmail.com.
authors: Nagaraja
authors: N
authors: Naik
authors: Department of Pharmaceutics, K.L.E. University College of Pharmacy, Vidyanagar, Hubli, Karnataka, India. Electronic address: jameelahmed5@rediffmail.com.
authors: Jameel Ahmed S
authors: JA
authors: Mulla
authors: Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India. Electronic address: avinash1081988@gmail.com.
authors: Avinash
authors: A
authors: Prakasha
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D004553:Electric Conductivity; D004583:Electrons; D008024:Ligands; D060328:Magnetic Phenomena; D008968:Molecular Conformation; D066244:Proton Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D056831:Coordination Complexes; D008024:Ligands; D004247:DNA; C427203:calf thymus DNA
keywords: Analgesic activity; Anti-inflammatory activity; DNA binding studies; Ligands; Metal complexes