title: Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients.
abstract: OBJECTIVE
  Our aim was to determinate the acenocoumarol dose requirement in highly sensitive geriatric patients, based on a minimum of genotype (VKORC1 and CYP2C9) data.
  
  
  METHODS
  We used a Gaussian kernel density estimation test to identify patients highly sensitive to the drug and PHARMACHIP®-Cuma test (Progenika Biopharma, SA, Grifols, Spain) to determine the CYP2C9 and VKORC1 genotype.
  
  
  RESULTS
  All highly sensitive geriatric patients were taking ≤5.6 mg/week of acenocoumarol (AC), and 86% of these patients presented the following genotypes: CYP2C9*1/*3 or CYP2C9*1/*2 plus VKORC1 A/G, CYP2C9*3/*3, or VKORC1 A/A.
  
  
  CONCLUSIONS
  VKORC1 A and CYP2C9*2 and/or *3 allelic variants extremely influence on AC dose requirement of highly sensitive geriatric patients. These patients display acenocoumarol dose requirement of ≤5.6 mg/week.
authors: Roberto
authors: R
authors: Lozano
authors: María-Esther
authors: ME
authors: Franco
authors: Luis
authors: L
authors: López
authors: Juan-José
authors: JJ
authors: Moneva
authors: Vicente
authors: V
authors: Carrasco
authors: Maria-Angeles
authors: MA
authors: Pérez-Layo
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D000367:Age Factors; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000925:Anticoagulants / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D065729:Cytochrome P-450 CYP2C9 / Q000235:genetics* / Q000378:metabolism; D054796:Drug Dosage Calculations; D016903:Drug Monitoring; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D010597:Pharmacogenetics; D010641:Phenotype; D010865:Pilot Projects; D064417:Vitamin K Epoxide Reductases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000925:Anticoagulants; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases; D000074:Acenocoumarol