title: The relation of object naming and other visual speech production tasks: a large scale voxel-based morphometric study.
abstract: We report a lesion-symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a 'shared' component that loaded across all the visual speech production tasks and a 'unique' component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual-speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.
authors: School of Psychology, University of Birmingham, Birmingham, UK.
authors: Johnny King L
authors: JK
authors: Lau
authors: School of Psychology, University of Birmingham, Birmingham, UK ; Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors: Glyn W
authors: GW
authors: Humphreys
authors: School of Psychology, University of Birmingham, Birmingham, UK ; Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK.
authors: Hassan
authors: H
authors: Douis
authors: School of Psychology, University of Birmingham, Birmingham, UK ; Department of Psychology, Edge Hill University, Lancashire, UK.
authors: Alex
authors: A
authors: Balani
authors: School of Psychology, University of Birmingham, Birmingham, UK.
authors: Wai-Ling
authors: WL
authors: Bickerton
authors: School of Psychology, University of Birmingham, Birmingham, UK.
authors: Pia
authors: P
authors: Rotshtein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D011857:Radiographic Image Interpretation, Computer-Assisted; D013060:Speech / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
keywords: BCoS; CT; Nonword reading; Picture description; Picture naming; Principal component analysis; Sentence production; Sentence reading; Speech production; Stroke; VBM