title: Highly efficient synthesis of chiral α-CF3 amines via Rh-catalyzed asymmetric hydrogenation.
abstract: Highly enantioselective catalytic asymmetric hydrogenation of α-CF3-enamides has been achieved by employing rhodium-DuanPhos as the catalyst, which provides a readily accessible method for the synthesis of chiral trifluoromethylated amines. The reaction has a broad substrate scope; both aryl- and alkyl-substituted α-CF3-enamides worked smoothly and afford the corresponding chiral amines in high yields and excellent enantioselectivities (up to 99% ee).
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, People's Republic of China.
authors: Jun
authors: J
authors: Jiang
authors: Wenxin
authors: W
authors: Lu
authors: Hui
authors: H
authors: Lv
authors: Xumu
authors: X
authors: Zhang