title: Gastric arrhythmias in gastroparesis: low- and high-resolution mapping of gastric electrical activity.
abstract: Gastric arrhythmias occur in gastroparesis but their significance is debated. An improved understanding is currently emerging, including newly-defined histopathologic abnormalities in gastroparesis. In particular, the observation that interstitial cells of Cajal are depleted and injured provides mechanisms for arrhythmogenesis in gastroparesis. Electrogastrography has been the dominant clinical method of arrhythmia analysis, but is limited by summative nature, low signal quality, and incomplete sensitivity and specificity. Recently, high-resolution (HR; multi-electrode) mapping has emerged, providing superior spatial data on arrhythmic patterns and mechanisms. However, HR mapping is invasive, and low-resolution approaches are being assessed as bridging techniques until endoscopic mapping is achieved.
authors: Department of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors: Gregory
authors: G
authors: O'Grady
authors: Division of Gastroenterology, GI Motility Clinic, University of Louisville, 220 Abraham Flexner Way, Suite 300, Louisville, KY 40202, USA. Electronic address: thomas.abell@louisville.edu.
authors: Thomas L
authors: TL
authors: Abell
mesh_terms: D004576:Electromyography; D005746:Gastric Emptying / Q000502:physiology*; D018589:Gastroparesis / Q000503:physiopathology*; D006801:Humans; D013270:Stomach / Q000503:physiopathology*
keywords: Electrogastrography; Interstitial cells of Cajal; Slow wave; Tachygastria