title: Predictors of functional capacity in colorectal cancer patients.
abstract: OBJECTIVE
  The aim of this study is to determine the predictors of functional capacity and explore the relationship between functional capacity, performance status, fatigue, quality of life, anxiety, and depression in colorectal cancer (CRC) patients.
  
  
  METHODS
  Forty-two patients diagnosed as stage II-III CRC according to tumor, node, metastasis (TNM) classification were included the study. Functional capacity, performance status, fatigue, quality of life, anxiety, and depression of CRC patients were assessed using six-minute walk distance (6MWD) in the six-minute walk test (6MWT), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), Brief Fatigue Inventory (BFI), Functional Assessment of Cancer Therapy-Colorectal (FACT-C), and Hospital Anxiety and Depression Scale (HADS), respectively. A multiple linear regression model was used to identify independent predictors of functional capacity.
  
  
  RESULTS
  The six-minute walk distance (6MWD) was intermediately and negatively correlated with ECOG-PS score (p = 0.001, r = -0.415), BFI-impact of fatigue on daily functioning score (p = 0.013, r = -0.379), and age (p = 0.040, r = -0.319). An intermediate and positive correlation was found between 6MWD and FACT-C score (p = 0.016, r = 0.369). The multiple regression analysis revealed that only ECOG-PS score was significant and independent predictor of the 6MWD, accounted for 34.8 % of the variance.
  
  
  CONCLUSIONS
  Performance status was found to be the only significant predictor of functional capacity in this study. Assessing performance status may have an essential role in order to predict functional capacity in CRC patients. Future studies that include a larger sample size would more clearly elucidate the predictors and relationships of functional capacity.
authors: School of Physical Therapy and Rehabilitation, Dokuz Eylul University, Inciralti, Izmir, Turkey, murat.tomruk@deu.edu.tr.
authors: Murat
authors: M
authors: Tomruk
authors: Didem
authors: D
authors: Karadibak
authors: Tuğba
authors: T
authors: Yavuzşen
authors: Tülay
authors: T
authors: Akman
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D015179:Colorectal Neoplasms / Q000503:physiopathology* / Q000523:psychology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D005080:Exercise Test; D005221:Fatigue / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D055815:Young Adult