title: New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.
abstract: Six Diels-Alder adducts (1-6) and nine prenylated flavanones (7-15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) and sanggenol Q (7) were new compounds. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques. Compounds 1-3, 9, 10, 12, 13 and 15 exhibited cytotoxic activity against five human tumour lines and compound 2 inhibited significantly selective cytotoxic activities towards HL-60 and AGS cells with IC50 of 3.4 and 3.6 μM. Compounds 3, 5, 9 and 12 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7.
authors: a Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming 650500 , Yunnan , P. R. China.
authors: Jing
authors: J
authors: Qin
authors: Min
authors: M
authors: Fan
authors: Juan
authors: J
authors: He
authors: Xing-De
authors: XD
authors: Wu
authors: Li-Yan
authors: LY
authors: Peng
authors: Jia
authors: J
authors: Su
authors: Xiao
authors: X
authors: Cheng
authors: Yan
authors: Y
authors: Li
authors: Ling-Mei
authors: LM
authors: Kong
authors: Rong-Tao
authors: RT
authors: Li
authors: Qin-Shi
authors: QS
authors: Zhao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D045744:Cell Line, Tumor / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D018922:HL-60 Cells / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D009569:Nitric Oxide / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D044950:Flavanones; D006576:Heterocyclic Compounds, 4 or More Rings; C000602380:sanggenol Q; C000602379:soroceal B; D009569:Nitric Oxide
keywords: Morus alba L; anti-inflammatory activity; cytotoxic activity; sanggenol Q; soroceal B