title: Hypothalamic-amygdalar-brainstem volume reduction in a patient with narcolepsy secondary to diffuse axonal injury.
abstract: A 17-year-old male with diffuse axonal injury (DAI) was referred to our psychiatric clinic with a diagnosis of depression. However, further investigation indicated that he had narcolepsy without cataplexy secondary to DAI. We assessed regional volume alterations in the patient; MRI analysis showed a significant decrease in the volume of the hypothalamus, left amygdala, and brainstem. Our findings add to further understanding of the structural basis of secondary narcolepsy, and may provide basis for future neuroimaging studies on sleep disturbances in traumatic brain injury (TBI).
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Walid
authors: W
authors: Yassin
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Genichi
authors: G
authors: Sugihara
authors: Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Naoya
authors: N
authors: Oishi
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Manabu
authors: M
authors: Kubota
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Shiho
authors: S
authors: Ubukata
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Toshiya
authors: T
authors: Murai
authors: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Keita
authors: K
authors: Ueda
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology*; D020833:Diffuse Axonal Injury / Q000150:complications* / Q000473:pathology; D006801:Humans; D007031:Hypothalamus / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009290:Narcolepsy / Q000209:etiology* / Q000473:pathology*; D009929:Organ Size
keywords: MRI; amygdala; diffuse axonal injury; hypothalamus; narcolepsy