title: Associations of fibroblast growth factor 23 and fetuin-A with coronary plaque burden and plaque composition in young adults.
abstract: The total burden of subclinical coronary artery disease (CAD) is significant among young adults. Serum fibroblast growth factor 23 (FGF-23) and fetuin-A are established predictors of morbidity and mortality because of cardiovascular disease. The objective of the study was to evaluate the relationship between subclinical CAD and serum FGF-23 and fetuin-A concentrations among a population of young adults.
  
  
  
  A total of 241 subjects younger than 45 years who had undergone coronary computed tomographic angiography (CCTA) were included in the study. In 117 patients, the CCTA detected subclinical CAD; the rest of the patients had no CAD detected on CCTA.
  
  
  
  Serum FGF-23 and fetuin-A levels were significantly increased in the CAD patients as compared with the non-CAD patients (26.7 [interquartile range, 22.4-31.9] vs 15.7 [interquartile range, 13.2-18.1] pg/mL and 904.7 [interquartile range, 695.5-1021.6] vs 469.6 [331.4-660.5] mg/L, respectively; P < 0.001 for both). Furthermore, a positive correlation was identified between FGF-23 and fetuin-A levels and the total number of plaques (r = 0.21 and r = 0.28, respectively; P < 0.001 for both). In multivariate logistic regression analysis, age, smoking status, uric acid, FGF-23, and fetuin-A levels were found to be independently associated with the presence of CAD.
  
  
  
  The presence of subclinical CAD is independently associated with FGF-23 and fetuin-A and could be used as novel risk markers of cardiovascular disease in the asymptomatic young adult population.
authors: From the *Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla; †Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital; and ‡Department of Cardiology, Bağcılar Education and Research Hospital, Istanbul; and §Department of Biochemistry, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey; ║Nephrology Clinic, Dialysis and Renal Transplant Center, G. I. Popa University Hospital of Medicine and Pharmacy, Iasi, Romania; and ¶Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
authors: Fatih
authors: F
authors: Akin
authors: Omer
authors: O
authors: Celik
authors: Burak
authors: B
authors: Ayca
authors: Ibrahim
authors: I
authors: Altun
authors: Vesile Ornek
authors: VO
authors: Diker
authors: Ismail
authors: I
authors: Bıyık
authors: Dimitrie
authors: D
authors: Siriopol
authors: Adrian
authors: A
authors: Covic
authors: Mehmet
authors: M
authors: Kanbay
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000175:diagnosis*; D012307:Risk Factors; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: C556354:AHSG protein, human; D015415:Biomarkers; C000717427:FGF23 protein, human; D060749:alpha-2-HS-Glycoprotein; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23