title: The role of serum intestinal fatty acid binding protein levels and D-lactate levels in the diagnosis of acute intestinal ischemia.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of serum intestinal fatty acid binding protein (I-FABP) and D-lactate measurements in the early diagnosis of acute intestinal ischemia.
  
  
  METHODS
  A total of 272 patients with a clinical diagnosis of acute abdomen were recruited for this trial over a 24-month period, and 37 healthy people were included in the study as controls. Serum I-FABP and D-lactate levels were measured by an enzyme-linked immunosorbent assay and compared in patients with intestinal ischemia vs. non-intestinal ischemia.
  
  
  RESULTS
  Of the 272 patients, 39 were diagnosed with intestinal ischemia and 233 were diagnosed with other cause of acute abdomen. The mean serum I-FABP and D-lactate levels in the patients with intestinal ischemia were 149.74±57.81ng/mL and 52.73±26.46 ug/mL, respectively, and were significantly higher compared with patients with non-intestinal ischemia (36.78±11.25ng/mL and 15.58±5.17 ug/mL, respectively) and with levels in the healthy control group (8.33±6.25 ng/mL and 5.47±1.64 ug/mL, respectively). Area under the curve for I-FABP and D-lactate were 0.85 and 0.69, and cut-off values of 93.07 ng/mL and 34.28 ug/mL, respectively.
  
  
  CONCLUSIONS
  Serum I-FABP and D-lactate can improve the diagnosis of intestinal ischemia in patients with acute abdomen who are at risk.
authors: Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China.
authors: Hui
authors: H
authors: Shi
authors: Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China. Electronic address: benyanwu@vip.sina.com.
authors: Benyan
authors: B
authors: Wu
authors: Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China.
authors: Jun
authors: J
authors: Wan
authors: Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China.
authors: Wenhui
authors: W
authors: Liu
authors: Department of Gastroenterology, Nan Lou Division, the PLA General Hospital, Beijing, China.
authors: Binbin
authors: B
authors: Su
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000097:blood* / Q000175:diagnosis*; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D050556:Fatty Acid-Binding Proteins; D019344:Lactic Acid