title: Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China.
abstract: Gout is a genetic or acquired metabolic disease caused by increase of uric acid synthesis resulted from purine metabolic abnormalities. Whether cGMP-dependent protein kinase 2 (cGKII/PRKG2) is correlated with gout remains controversial. The objective of the present study was to investigate whether there is a correlation between polymorphism of cGKII/PRKG2 and gout susceptibility of Han population in northern China. Four hundred and five male patients with gout in the case group and 429 controls in the control group were collected from the Department of Endocrinology and Metabolic Disease, the Fourth Affiliated Hospital of Harbin Medical University. A case-control study method was used to study the correlation between cGKII/PRKG2 polymorphism rs7688672 and rs10033237 and gout susceptibility. The genotype frequencies of rs7688672 and rs10033237 polymorphisms of cGKII/PRKG2 in the case group and the control group both were in accordance with Hardy-Weinberg equilibrium. There were significant differences of rs10033237 in the allele frequencies and genotype distributions (P<0.05) between the two groups, while no association was found between rs7688672 and gout. Combined mutation sites AA(*) from rs7688672 and rs10033237 were negatively correlated with gout susceptibility, whereas haplotype GG(*) was positively correlated with gout susceptibility. In conclusion, patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout. With regard to haplotypes of rs10033237 and rs7688672, both AA(*) and GG(*) are related to gout. AA(*) is a gout susceptible gene, whereas GG(*) is a protective gene.
authors: Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Min
authors: M
authors: Guo
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Zhifeng
authors: Z
authors: Cheng
authors: Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
authors: Changgui
authors: C
authors: Li
authors: College of Pharmacy, Harbin Medical University, Harbin 150086, China.
authors: Shanshan
authors: S
authors: Li
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Ming
authors: M
authors: Li
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Mingli
authors: M
authors: Wang
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Jinmei
authors: J
authors: Xu
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Yingying
authors: Y
authors: Tang
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Yujing
authors: Y
authors: Wang
authors: Department of Endocrinology and Metabolic Disease, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Wenli
authors: W
authors: Qiu
authors: Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address: liuxiaomin620@126.com.
authors: Xiaomin
authors: X
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D062967:Cyclic GMP-Dependent Protein Kinase Type II / Q000235:genetics*; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D062967:Cyclic GMP-Dependent Protein Kinase Type II; C569729:PRKG2 protein, human
keywords: Allele frequencies; Genotype frequency; Gout susceptibility; Haplotype; Polymorphism