title: Relationship between relative interdialytic weight gain and serum leptin levels, nutrition, and inflammation in chronic hemodialysis patients.
abstract: BACKGROUND
  Excessive relative interdialytic weight gain (RIDWG, %) is an important risk factor for long-term adverse cardiovascular outcomes in chronic hemodialysis (HD) patients. On the other hand, it may also be an index of good appetite and nutritional status. We aimed to assess the relationship between RIDWG and appetite, nutrition, inflammation parameters of chronic HD patients.
  
  
  METHODS
  100 chronic anuric HD patients were enrolled in this prospective study between January 2013 and January 2014. Patients with hospitalization, major surgery, obvious infectious/inflammatory disease, end-stage liver disease, malignancies, and malabsorption syndromes were excluded. Patients were divided into 3 groups according to their RIDWG levels; group 1 = RIDWG < 3%, group 2 = RIDWG: 3 - 5%, and group 3 = RIDWG > 5%.
  
  
  RESULTS
  Group 3 patients were younger (p = 0.011) and had a lower body mass index (BMI) (p = 0.014). Nutrition and inflammation parameters including malnutrition inflammation score (MIS), serum albumin, prealbumin, triceps skinfold thickness, hs-CRP, and TNF-α ere not significantly different between the groups. Leptin and leptin/BMI ratio were significantly lower in group 3 (p = 0.001). RIDWG was negatively correlated with age (p = 0.001, r = -0.371), BMI (p = 0.001, r = -0.372), leptin (p = 0.001, r = -0.369), leptin/BMI (p = 0.001, r = -0.369). After adjustment for BMI in linear regression analyis, leptin/BMI remained significantly correlated with RIDWG (p = 0.024).
  
  
  CONCLUSIONS
  This study revealed that RIDWG was associated with younger age, lower BMI and dry weight, and lower serum leptin levels. More detailed studies are needed to validate and dissect the mechanisms of these findings.
authors: Department of Nephrology, Sisli Etfal Research and Educational Hospital, Istanbul, Turkey.
authors: Elbis
authors: E
authors: Ahbap
authors: Tamer
authors: T
authors: Sakaci
authors: Ekrem
authors: E
authors: Kara
authors: Tuncay
authors: T
authors: Sahutoglu
authors: Yener
authors: Y
authors: Koc
authors: Taner
authors: T
authors: Basturk
authors: Mustafa
authors: M
authors: Sevinc
authors: Cuneyt
authors: C
authors: Akgol
authors: Arzu Ozdemir
authors: AO
authors: Kayalar
authors: Zuhal Atan
authors: ZA
authors: Ucar
authors: Feyza
authors: F
authors: Bayraktar
authors: Abdulkadir
authors: A
authors: Unsal
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects; D012709:Serum Albumin / Q000032:analysis; D015430:Weight Gain
chemical_list: D020738:Leptin; D012709:Serum Albumin