title: The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.
abstract: BRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as a regulator of cell growth and apoptosis. In this study, targeted gene deletion showed that BRAT1 is critical in stability and serum-induced expression of mTOR and downstream protein. Conditional deletion of BRAT1 of mouse embryonic fibroblasts suppressed serum-induced cell cycling progress. Our results suggest that BRAT1 is essential factor for PIKK signaling cascades.
authors: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors: Eui Young
authors: EY
authors: So
authors: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors: Toru
authors: T
authors: Ouchi
keywords: BRCA1; Cell cycle; Cell signaling; Human cervical carcinoma