title: Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats.
abstract: Our laboratory has previously reported that chronic, voluntary exercise diminishes seizure-related behaviors induced by convulsant doses of kainic acid. The present experiments tested the hypothesis that exercise exerts this protective effect through a mechanism involving suppression of glutamate release in the hippocampal formation. Following three weeks of voluntary wheel running or sedentary conditions, rats were injected with 10 mg/kg of kainic acid, and hippocampal glutamate was measured in real time using a telemetric, in vivo voltammetry system. A separate experiment measured electroencephalographic (EEG) activity following kainic acid treatment. Results of the voltammetry experiment revealed that the rise in hippocampal glutamate induced by kainic acid is attenuated in exercising rats compared to sedentary controls, indicating that the exercise-induced protection against seizures involves regulation of hippocampal glutamate release. The findings reveal the potential benefit of regular exercise in the treatment and prevention of seizure disorders and suggest a possible neurobiological mechanism underlying this effect.
authors: Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States. Electronic address: pvholmes@uga.edu.
authors: Philip V
authors: PV
authors: Holmes
authors: Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States.
authors: Jenny I
authors: JI
authors: Reiss
authors: Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States.
authors: Patrick S
authors: PS
authors: Murray
authors: Department of Kinesiology, The University of Georgia, Athens, GA, United States.
authors: Rod K
authors: RK
authors: Dishman
authors: Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA, United States.
authors: Jessica M
authors: JM
authors: Spradley
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000503:physiopathology*; D006799:Housing, Animal; D007608:Kainic Acid; D008297:Male; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D012420:Running / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology*; D013686:Telemetry
chemical_list: D018698:Glutamic Acid; D007608:Kainic Acid