title: Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats.
abstract: The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.
authors: Department of Animal Science, Faculty of Agriculture, University of Dicle, Diyarbakir 21280, Turkey. Electronic address: muzaffer.denli@gmail.com.
authors: Muzaffer
authors: M
authors: Denli
authors: Animal Nutrition, Management and Welfare Research Group, Department of Animal and Food Science, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
authors: Juan C
authors: JC
authors: Blandon
authors: Adiveter, S. L. Pol. Ind. Agro-Reus, Reus, Tarragona, Spain.
authors: Silvia
authors: S
authors: Salado
authors: Adiveter, S. L. Pol. Ind. Agro-Reus, Reus, Tarragona, Spain.
authors: Maria E
authors: ME
authors: Guynot
authors: Department of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona, 18, Barcelona 08034, Spain.
authors: Josefina
authors: J
authors: Casas
authors: Animal Nutrition, Management and Welfare Research Group, Department of Animal and Food Science, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
authors: Jose F
authors: JF
authors: Pérez
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D037341:Fumonisins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D064449:Sequestering Agents / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D037341:Fumonisins; D064449:Sequestering Agents; D014280:Triglycerides; D014527:Uric Acid; C056933:fumonisin B1; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D013110:Sphingosine; C005682:safingol
keywords: Adsorbent; Fumonisin B(1); Toxicity and rats