title: Controllable construction of titanium dioxide-zirconium dioxide@zinc hydroxyfluoride networks in micro-capillaries for bio-analysis.
abstract: Glass/silica-based flow channels are widely used in capillary electrophoresis and micro-total analysis systems. However, it is almost impossible to achieve controllable fabrication of microstructures with enhanced mixing performance for high-efficiency bio-analysis in confined micro-channels. Here, various morphologies were controllably achieved by tuning the molar ratio of the reaction agents in a confined microchannel. Fluid flow simulation is demonstrated to investigate the structure stability and mixing performance. Multifunctional networks with uniform and deep decoration are fabricated in confined micro-capillaries, owing to the enhanced mixing performance. The modified micro-capillaries exhibit high efficiencies for the selective enrichment of phosphopeptides from traditional model samples. Furthermore, the fabricated micro-capillaries also exhibited high performance in practical applications (for selective enrichments from bovine milk and cancer serum). These outstanding features make the microstructure-modified micro-capillaries promising for bio-analysis.
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 20160, China.
authors: Gang
authors: G
authors: Wang
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 20160, China.
authors: Zhongyuan
authors: Z
authors: He
authors: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 20160, China.
authors: Guoying
authors: G
authors: Shi
authors: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 20160, China. Electronic address: wanghz@dhu.edu.cn.
authors: Hongzhi
authors: H
authors: Wang
authors: Engineering Research Center of Advanced Glasses Manufacturing Technology (MOE), College of Materials Science and Engineering, Donghua University, Shanghai 20160, China.
authors: Qinghong
authors: Q
authors: Zhang
authors: Engineering Research Center of Advanced Glasses Manufacturing Technology (MOE), College of Materials Science and Engineering, Donghua University, Shanghai 20160, China. Electronic address: yaogang_li@dhu.edu.cn.
authors: Yaogang
authors: Y
authors: Li
mesh_terms: D000818:Animals; D002417:Cattle; D015179:Colorectal Neoplasms / Q000097:blood*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D005459:Fluorides / Q000737:chemistry*; D005898:Glass / Q000737:chemistry; D006801:Humans; D008892:Milk / Q000737:chemistry*; D010748:Phosphopeptides / Q000032:analysis*; D012822:Silicon Dioxide / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D010748:Phosphopeptides; C009495:titanium dioxide; D012822:Silicon Dioxide; D015040:Zirconium; D014025:Titanium; D015032:Zinc; D005459:Fluorides; C028541:zirconium oxide
keywords: 3D network; Cancer serum; Enhanced mixing; Microfluidic technology