title: Belching, regurgitation, chest tightness and dyspnea: not gastroesophageal reflux disease but asthma.
abstract: Belching is a common symptom of gastroesophageal reflux disease. If the symptoms are not relieved after anti-reflux treatment, another etiology should be considered. Here, we report a case of a 43-year-old man who presented with belching, regurgitation, chest tightness and dyspnea for 18 mo, which became gradually more severe. Gastroscopic examination suggested superficial gastritis. Twenty-four-hour esophageal pH monitoring showed that the Demeester score was 11.4, in the normal range. High-resolution manometry showed that integrated relaxation pressure and intrabolus pressure were higher than normal (20 mmHg and 22.4 mmHg, respectively), indicating gastroesophageal junction outflow tract obstruction. Pulmonary function test showed severe obstructive ventilation dysfunction [forced expiratory volume in 1 second (FEV1)/forced vital capacity 32%, FEV1 was 1.21 L, occupying 35% predicted value after salbuterol inhalation], and positive bronchial dilation test (∆FEV1 260 mL, ∆FEV1% 27%). Skin prick test showed Dermatophagoides farinae (++), house dust mite (++++), and shrimp protein (++). Fractional exhaled nitric oxide measurement was 76 ppb. All the symptoms were alleviated completely and pulmonary function increased after combination therapy with corticosteroids and long-acting β2-agonist. Bronchial asthma was eventually diagnosed by laboratory tests and the effect of anti-asthmatic treatment, therefore, physicians, especially the Gastrointestinal physicians, should pay attention to the belching symptoms of asthma.
authors: Jing-Xi Zhang, Chong Bai, Qiang Li, Department of Respiratory diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors: Jing-Xi
authors: JX
authors: Zhang
authors: Jing-Xi Zhang, Chong Bai, Qiang Li, Department of Respiratory diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors: Xian-Bao
authors: XB
authors: Zhan
authors: Jing-Xi Zhang, Chong Bai, Qiang Li, Department of Respiratory diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors: Chong
authors: C
authors: Bai
authors: Jing-Xi Zhang, Chong Bai, Qiang Li, Department of Respiratory diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors: Qiang
authors: Q
authors: Li
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage; D000328:Adult; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D004884:Eructation / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D050782:Esophageal pH Monitoring; D005541:Forced Expiratory Volume; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005773:Gastroscopy; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome; D014797:Vital Capacity
chemical_list: D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents
keywords: Asthma; Gastroesophageal reflux disease