title: Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review.
abstract: Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs.
authors: Phytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt ; Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Mohamed-Elamir F
authors: ME
authors: Hegazy
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Tarik A
authors: TA
authors: Mohamed
authors: Department of Natural Compounds Chemistry, National Research Centre, Dokki, 12311 Cairo, Egypt.
authors: Abdelsamed I
authors: AI
authors: ElShamy
authors: Department of Chemistry, Aswan-Faculty of Science, South Valley University, Aswan, Egypt.
authors: Abou-El-Hamd H
authors: AE
authors: Mohamed
authors: Department of Botany, Aswan-Faculty of Science, South Valley University, Aswan, Egypt.
authors: Usama A
authors: UA
authors: Mahalel
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Eman H
authors: EH
authors: Reda
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Alaa M
authors: AM
authors: Shaheen
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Wafaa A
authors: WA
authors: Tawfik
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt ; Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
authors: Abdelaaty A
authors: AA
authors: Shahat
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Khalid A
authors: KA
authors: Shams
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Nahla S
authors: NS
authors: Abdel-Azim
authors: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors: Fayza M
authors: FM
authors: Hammouda
keywords: Biotransformation; Microbial biocatalysts; Natural products; Pharmaceutical products