title: [Impairments of rats' behavioral reactions, concentration of corticosterone and expression of cytokine's gene under experimental postviral fatigue].
abstract: The aim of the main research was investigated of interaction of neural, endocrine and immune systems under experimental postviral fatigue, behavioral reactions, level of corticosterone, changes of IL-3 and IL-10 gene expression in rats' hypothalamus and INF-α in hypothalamus and spleen were analyzed. It has been shown the decrease of physical activity, increasing of corticosterone's level and gene expression of cytokines after injection of Poly I:C as a model of postviral fatigue. After remedication of Poly I:C increasing of physical activity was shown.
authors: T A
authors: TA
authors: Filatenkova
authors: E V
authors: EV
authors: Dmitrienko
authors: E E
authors: EE
authors: Fomicheva
authors: S N
authors: SN
authors: Shanin
authors: E G
authors: EG
authors: Rybakina
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D015673:Fatigue Syndrome, Chronic / Q000139:chemically induced / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D015870:Gene Expression; D007031:Hypothalamus / Q000276:immunology / Q000503:physiopathology*; D007113:Immunity, Innate; D016898:Interferon-alpha / Q000235:genetics / Q000276:immunology; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D007377:Interleukin-3 / Q000235:genetics / Q000276:immunology; D008297:Male; D009043:Motor Activity / Q000235:genetics / Q000276:immunology*; D011070:Poly I-C; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology / Q000503:physiopathology*; D013550:Swimming
chemical_list: D016898:Interferon-alpha; D007377:Interleukin-3; D016753:Interleukin-10; D011070:Poly I-C; D003345:Corticosterone