title: Assessment and diagnosis of suspected glaucoma in patients with mucopolysaccharidosis.
abstract: OBJECTIVE
  The mucopolysaccharidoses (MPS) are a group of rare lysosomal storage disorders, characterized by the accumulation of glycosaminoglycans within multiple organ systems including the eye. This study aimed to determine the prevalence of glaucoma in patients with MPS, as well as the characteristics, diagnosis and management of patients with MPS and glaucoma.
  
  
  METHODS
  A multicentre retrospective case-note review was carried out by ophthalmologists from four tertiary referral centres to identify patients with MPS who had been treated for glaucoma. Clinical ophthalmological data were collected using standardized data collection forms.
  
  
  RESULTS
  Fourteen patients were identified (27 eyes) of 294 patients with MPS. The prevalence of glaucoma ranged from 2.1% to 12.5%. The median age at diagnosis of glaucoma was 8 years. Diagnostic evaluation of glaucoma was incomplete in many patients: intraocular pressure was documented in all eyes, but optic disc appearance was only assessed in 67%, central corneal thickness in 26%, visual fields in 19% and iridocorneal angle in 15%.
  
  
  CONCLUSIONS
  Patients with MPS need regular assessment for possible glaucoma including during childhood. Multiple factors contribute to the challenges of assessment, diagnosis and monitoring of glaucoma in these patients.
authors: Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
authors: Jane
authors: J
authors: Ashworth
authors: Maree
authors: M
authors: Flaherty
authors: Susanne
authors: S
authors: Pitz
authors: Azura
authors: A
authors: Ramlee
mesh_terms: D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000502:physiology; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D009083:Mucopolysaccharidoses / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009798:Ocular Hypertension / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D009898:Optic Disk / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014130:Trabeculectomy; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: Hunter; Hurler; Hurler-Scheie; Maroteaux-Lamy; Morquio; Scheie; glaucoma; mucopolysaccharidosis; prevalence