title: Modulation of the cardiomyocyte contraction inside a hydrostatic pressure bioreactor: in vitro verification of the Frank-Starling law.
abstract: We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.
authors: Dipartimento di Ingegneria Industriale e dell'Informazione, Università di Pavia, Via Ferrata 1, 27100 Pavia, Italy ; Centro di Ingegneria Tissutale (CIT), Università di Pavia, 27100 Pavia, Italy.
authors: Lorenzo
authors: L
authors: Fassina
authors: Dipartimento di Ingegneria Industriale e dell'Informazione, Università di Pavia, Via Ferrata 1, 27100 Pavia, Italy ; Centro di Ingegneria Tissutale (CIT), Università di Pavia, 27100 Pavia, Italy.
authors: Giovanni
authors: G
authors: Magenes
authors: Dipartimento di Medicina Sperimentale, Università "Sapienza", 00161 Roma, Italy.
authors: Roberto
authors: R
authors: Gimmelli
authors: Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell'Apparato Locomotore, Università "Sapienza", 00161 Roma, Italy.
authors: Fabio
authors: F
authors: Naro
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology*; D019149:Bioreactors; D002478:Cells, Cultured; D015726:Giant Cells / Q000166:cytology / Q000502:physiology; D006874:Hydrostatic Pressure; D051379:Mice; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000502:physiology*