title: Progesterone and the luteal phase: a requisite to reproduction.
abstract: Progesterone production from the corpus luteum is critical for natural reproduction. Progesterone supplementation seems to be an important aspect of any assisted reproductive technology treatment. Luteal phase deficiency in natural cycles is a plausible cause of infertility and pregnancy loss, though there is no adequate diagnostic test. This article describes the normal luteal phase of the menstrual cycle, investigates the controversy surrounding luteal phase deficiency, and presents the current literature for progesterone supplementation during assisted reproductive technologies.
authors: Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA. Electronic address: tolga_mesen@med.unc.edu.
authors: Tolga B
authors: TB
authors: Mesen
authors: Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA.
authors: Steven L
authors: SL
authors: Young
mesh_terms: D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008183:Luteal Phase / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000172:deficiency* / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use; D027724:Reproductive Techniques, Assisted
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone
keywords: ART; Luteal phase; Luteal phase deficiency; Luteal phase support; Progesterone