title: Blood type gene locus has no influence on ACE association with Alzheimer's disease.
abstract: The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.
authors: Human Genetics Group, Translational Cell Sciences, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
authors: Anne
authors: A
authors: Braae
authors: Human Genetics Group, Translational Cell Sciences, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
authors: Christopher
authors: C
authors: Medway
authors: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, FL, USA.
authors: Minerva
authors: M
authors: Carrasquillo
authors: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, FL, USA.
authors: Steven
authors: S
authors: Younkin
authors: Dementia Research Group, University of Bristol, Level 1, Learning & Research, Southmead Hospital, Bristol, UK. Electronic address: Patrick.Kehoe@bristol.ac.uk.
authors: Patrick G
authors: PG
authors: Kehoe
authors: Human Genetics Group, Translational Cell Sciences, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
authors: Kevin
authors: K
authors: Morgan
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System; D007703:Peptidyl-Dipeptidase A
keywords: ABO blood group; Alzheimer's disease; Angiotensin-converting enzyme; Genome-wide association study