title: A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics.
abstract: A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).
authors: Department of Chemical and Biomolecular Engineering, National University of Singapore , Singapore 117576, Singapore.
authors: Qinglian
authors: Q
authors: Hu
authors: Meng
authors: M
authors: Gao
authors: Guangxue
authors: G
authors: Feng
authors: Xiaodong
authors: X
authors: Chen
authors: Bin
authors: B
authors: Liu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D018613:Microscopy, Confocal; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D010848:Picolinic Acids / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D008081:Liposomes; D009942:Organometallic Compounds; D010848:Picolinic Acids; C529174:bis-dipicolylamine-Zinc(II); D006861:Hydrogen Peroxide
keywords: aggregation-induced emission; cell apoptosis; lipid droplet; zinc coordination