title: Accelerating aging research: how can we measure the rate of biologic aging?
abstract: Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such phenotypes can only be derived by observational data. However, a clinical phenotype of aging exists that is experienced by all living individuals and is pervasive across multiple physiologic systems. Characterizing this phenotype can serve as a basis for measuring the speed of aging, and can facilitate a better understanding of the aging process and its interaction with chronic diseases.
authors: Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA. Electronic address: jmargol1@jhu.edu.
authors: Joseph B
authors: JB
authors: Margolick
authors: National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address: ferruccilu@grc.nia.nih.gov.
authors: Luigi
authors: L
authors: Ferrucci
mesh_terms: D000375:Aging / Q000235:genetics*; D019588:Aging, Premature / Q000235:genetics*; D005853:Geriatrics; D006801:Humans; D010641:Phenotype
keywords: Accelerated aging; Age-associated diseases; Aging phenotype; Gerosciences