title: Nuclear Reprogramming and Mitosis--how does mitosis enhance changes in gene expression?
abstract: Nuclear reprogramming changes the identity of cells by changing gene expression programmes. Two recent pieces of work have highlighted the role that mitosis plays in enhancing the success of nuclear reprogramming. This Point of View article examines this work in the context of nuclear reprogramming.
authors: a Faculty of Health Sciences, University of Cape Town , Anzio Road, Observatory , Cape Town , South Africa.
authors: Richard P
authors: RP
authors: Halley-Stott
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D002843:Chromatin / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D054875:Ubiquitination
chemical_list: D002843:Chromatin
keywords: GV, Germinal Vesicle; H2BK120, Histone H2B lysine 120; K4me3, Lysine 4 trimethyl; K9me3, Lysine 9 trimethyl; cell cycle; cell fusion; cell identity; iPS; iPS, induced Pluripotent Stem; mitosis; nuclear transfer; pluripotent; reprogramming; transcription