title: Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T).
abstract: Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid residues were determined on the basis of intensive NMR and ESI-MS/MS spectroscopic analysis, in addition to the Marfey's method and CD and optical rotation data for the configurational assignment. Both 1 and 2 exhibited significant cytotoxic activities against a panel of human tumor cell lines.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P.R. China.
authors: Dong
authors: D
authors: Liu
authors: Hong
authors: H
authors: Lin
authors: Peter
authors: P
authors: Proksch
authors: Xixiang
authors: X
authors: Tang
authors: Zhongze
authors: Z
authors: Shao
authors: Wenhan
authors: W
authors: Lin
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000192:Actinomycetales / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D054848:Peptaibols / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053719:Tandem Mass Spectrometry
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D054848:Peptaibols; C000601269:microbacterin A; C000601270:microbacterin B