title: [Irritable Bowel Syndrome; gut microbiota and probiotic therapy].
abstract: Irritable bowel syndrome (IBS) is characterized by symptoms of abdominal pain and altered bowel habits. This common disorder is managed by varying clinical styles as no dominant therapeutic strategy has emerged. The pathophysiology of IBS remains unknown, but several lines of evidence link this disorder with the gut microbiota. Although controversy exists, gut microbiota is likely contributing to symptoms of IBS, at least in some patients, through an altered fermentation process, an impaired intestinal barrier function, a harmful modulation of enteric sensorimotor function, a promotion of low-grade inflammation without tissue damage, and a harmful modulation of the brain-gut axis. Probiotic therapy has a modest effect on IBS symptomatic relief, but the actual evidence is not strong enough to support a general recommendation of use. The best results are achieved, in children, with Lactobacillus rhamnusus GG, which moderately improves abdominal pain, while in adults the benefit appears to be greatest employing Bifidobacterium species.
authors: Aparato Digestivo, Hospital de Cabueñes Gijón.. rafael_tojo@msn.com.
authors: Rafael
authors: R
authors: Tojo González
authors: Aparato Digestivo, Hospital Universitario Central de Asturias..
authors: Adolfo
authors: A
authors: Suarez Gonzalez
authors: Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas..
authors: Patricia
authors: P
authors: Rúas Madiedo
authors: Aparato Digestivo, Hospital de Cabueñes Gijón..
authors: Alejo
authors: A
authors: Mancebo Mata
authors: Aparato Digestivo, Hospital de Cabueñes Gijón..
authors: María
authors: M
authors: Pipa Muñiz
authors: Aparato Digestivo, Hospital de Cabueñes Gijón..
authors: Eva
authors: E
authors: Barreiro Alonso
authors: Aparato Digestivo, Hospital de Cabueñes Gijón..
authors: Francisco Javier
authors: FJ
authors: Roman Llorente
authors: Diplomada Universitaria en Enfermería, Hospital Universitario Central de Asturias, Oviedo..
authors: María Carmen
authors: MC
authors: Moro Villar
authors: Diplomada Universitaria en Enfermería, Hospital de Cabueñes Gijón. España..
authors: Marta María
authors: MM
authors: Arce González
authors: Diplomada Universitaria en Enfermería, Hospital de Cabueñes Gijón. España..
authors: María Francisca
authors: MF
authors: Villegas Diaz
authors: Diplomada Universitaria en Enfermería, Hospital de Cabueñes Gijón. España..
authors: Eugenia
authors: E
authors: Mosquera Sierra
authors: Diplomada Universitaria en Enfermería, Hospital de Cabueñes Gijón. España..
authors: Mónica
authors: M
authors: Ruiz Ruiz
mesh_terms: D000328:Adult; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D064307:Microbiota; D019936:Probiotics / Q000627:therapeutic use*