title: Alginate-sterculia gum gel-coated oil-entrapped alginate beads for gastroretentive risperidone delivery.
abstract: Novel floating-mucoadhesive oil-entrapped alginate beads coated with crossslinked alginate-sterculia gum gel membrane was developed for gastroretentive risperidone delivery. Oil-entrapped alginate beads containing risperidone as core were prepared by ionotropic gelation technique. Effects of polymer to drug ratio and oil to water ratio on drug entrapment efficiency (%) and cumulative drug release after 8h (%) were studied to optimize the core beads by a 3(2) factorial design. The optimized beads (F-O) demonstrated drug entrapment efficiency of 83.73±0.81% and cumulative drug release of 70.84±0.27% after 8h. The biopolymeric-coated optimized beads exhibited excellent buoyancy, better ex vivo mucoadhesion and slower drug release rate. The drug release profiles of risperidone-loaded uncoated and coated beads were best fitted in Korsmeyer-Peppas model with Fickian diffusion mechanism. The beads were also examined for the drug-excipients compatibility, drug crystallinity and surface morphology by FTIR, P-XRD and SEM analyses, respectively.
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. Electronic address: hriday.bera1@gmail.com.
authors: Hriday
authors: H
authors: Bera
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
authors: Saisharan Goud
authors: SG
authors: Kandukuri
authors: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Jharpokharia 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors: Amit Kumar
authors: AK
authors: Nayak
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
authors: Shashank
authors: S
authors: Boddupalli
mesh_terms: D000464:Alginates / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D009821:Oils / Q000737:chemistry; D018967:Risperidone / Q000008:administration & dosage*; D012702:Serotonin Antagonists / Q000008:administration & dosage*; D032361:Sterculia / Q000737:chemistry*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D009821:Oils; D012702:Serotonin Antagonists; D020723:Glucuronic Acid; D018967:Risperidone
keywords: Alginate; Floatation; Mucoadhesion; Olive oil; Risperidone; Sterculia gum