title: Effective connectivity of depth-structure-selective patches in the lateral bank of the macaque intraparietal sulcus.
abstract: Extrastriate cortical areas are frequently composed of subpopulations of neurons encoding specific features or stimuli, such as color, disparity, or faces, and patches of neurons encoding similar stimulus properties are typically embedded in interconnected networks, such as the attention or face-processing network. The goal of the current study was to examine the effective connectivity of subsectors of neurons in the same cortical area with highly similar neuronal response properties. We first recorded single- and multi-unit activity to identify two neuronal patches in the anterior part of the macaque intraparietal sulcus (IPS) showing the same depth structure selectivity and then employed electrical microstimulation during functional magnetic resonance imaging in these patches to determine the effective connectivity of these patches. The two IPS subsectors we identified-with the same neuronal response properties and in some cases separated by only 3 mm-were effectively connected to remarkably distinct cortical networks in both dorsal and ventral stream in three macaques. Conversely, the differences in effective connectivity could account for the known visual-to-motor gradient within the anterior IPS. These results clarify the role of the anterior IPS as a pivotal brain region where dorsal and ventral visual stream interact during object analysis. Thus, in addition to the anatomical connectivity of cortical areas and the properties of individual neurons in these areas, the effective connectivity provides novel key insights into the widespread functional networks that support behavior.
authors: Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium.
authors: Elsie
authors: E
authors: Premereur
authors: Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium.
authors: Ilse C
authors: IC
authors: Van Dromme
authors: Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium.
authors: Maria C
authors: MC
authors: Romero
authors: Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Wim
authors: W
authors: Vanduffel
authors: Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium.
authors: Peter
authors: P
authors: Janssen
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D004558:Electric Stimulation; D004566:Electrodes; D018737:Hand Strength / Q000502:physiology; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D012438:Saccades / Q000502:physiology; D013238:Stereotaxic Techniques