title: The Burden of Healthcare-Associated Infections in Southeast Asia: A Systematic Literature Review and Meta-analysis.
abstract: A systematic literature review and meta-analysis of the burden of healthcare-associated infections (HAIs) in Southeast Asia was performed on 41 studies out of the initially identified 14 089 records. The pooled prevalence of overall HAIs was 9.0% (95% confidence interval [CI], 7.2%-10.8%), whereas the pooled incidence density of HAI was 20 cases per 1000 intensive care unit-days. The pooled incidence density of ventilator-associated pneumonia, central line-associated bloodstream infection, and catheter-associated urinary tract infection was 14.7 per 1000 ventilator-days (95% CI, 11.7-17.7), 4.7 per 1000 catheter-days (95% CI, 2.9-6.5), and 8.9 per 1000 catheter-days (95% CI, 6.2-11.7), respectively. The pooled incidence of surgical site infection was 7.8% (95% CI, 6.3%-9.3%). The attributed mortality and excess length of stay in hospitals of infected patients ranged from 7% to 46% and 5 to 21 days, respectively.
authors: Infection Control, Singapore General Hospital, Singapore.
authors: Moi Lin
authors: ML
authors: Ling
authors: Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand.
authors: Anucha
authors: A
authors: Apisarnthanarak
authors: Department of Epidemiology and Biostatistics, College of Public Health, University of the Philippines, Manila.
authors: Gilbert
authors: G
authors: Madriaga
mesh_terms: D001210:Asia, Southeastern / Q000453:epidemiology; D055499:Catheter-Related Infections / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology; D015995:Prevalence; D018805:Sepsis / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology
keywords: Southeast Asia; epidemiology; healthcare-associated infections; meta-analysis; systematic literature review