title: Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas.
abstract: BACKGROUND
  Calcitriol [1,25(OH)2D] is hypothesized to lower the risk of cancer via binding to the vitamin D receptor (VDR). VDRs are also found in benign and malignant cells of mesenchymal origin. To our knowledge, vitamin D levels and dietary intake have not been previously evaluated in patients newly diagnosed with benign and malignant mesenchymal tumors.
  
  
  METHODS
  Forty-eight patients with benign soft tissue tumors and 25 patients with sarcoma had their serum 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and parathyroid hormone levels measured, vitamin D intake scored and body mass index [BMI] calculated.
  
  
  RESULTS
  Vitamin D deficiency [25(OH)D level<50 nmol/l] was observed in 19% and 28% of patients with benign tumor and sarcoma, respectively.
  
  
  CONCLUSIONS
  Serum 25(OH)D, 1,25(OH)2D and parathyroid hormone concentrations, BMI and daily vitamin D intake did not differ significantly between the two groups of patients. Higher vitamin D intake or UV exposure is needed to ensure that all patients achieve sufficient vitamin D levels.
authors: Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway astaj@rr-research.no.
authors: Asta
authors: A
authors: Juzeniene
authors: Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
authors: Alina Carmen
authors: AC
authors: Porojnicu
authors: Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
authors: Zivile
authors: Z
authors: Baturaite
authors: Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
authors: Zoya
authors: Z
authors: Lagunova
authors: Department of Paediatrics, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, University of Bergen, Norway.
authors: Lage
authors: L
authors: Aksnes
authors: Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
authors: Øyvind Sverre
authors: ØS
authors: Bruland
authors: Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway Institute of Physics, University of Oslo, Oslo, Norway.
authors: Johan
authors: J
authors: Moan
mesh_terms: D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000097:blood*; D012983:Soft Tissue Neoplasms / Q000097:blood*; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*
chemical_list: D014807:Vitamin D
keywords: 1,25-dihydroxyvitamin D; 25-Hydroxyvitamin D; benign soft tissue tumor; daily vitamin D intake; parathyroid hormone; sarcoma