title: p42.3 promotes cell proliferation and invasion in human Renal-Cell Carcinoma.
abstract: p42.3 is a tumor-specific gene and found to be over-expressed in many tumor cell lines and primary tumor tissues. It plays a significant role in neoplastic transformation and tumor progression. To date, the association between p42.3 and Renal-Cell Carcinoma (RCC) has not been reported. This study investigated the biological effects and mechanisms of p42.3 in RCC progression. In this study, we found that p42.3 is overexpressed in various kinds of RCC cells, and knockdown of p42.3 dramatically reduced cell proliferation and invasion in vitro. Our studies revealed that overexpression of p42.3 accelerates the epithelial-mesenchymal transition (EMT) progression and induces RCC cells proliferation and invasion. Further studies show that p42.3 may involve in activation of β-catenin and participate in RCC cell invasion. Combined, these data indicate that p42.3 contributes to promoting RCC cells proliferation and invasion through accelerates the EMT progression and β-catenin activation.
authors: Department of Otorhinolaryngology, Affiliated Hospital of Xuzhou Medical College Xuzhou 221002, China.
authors: Pei-Hua
authors: PH
authors: Li
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College Xuzhou 221002, China.
authors: Wen-Jia
authors: WJ
authors: Cao
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College Xuzhou 221002, China.
authors: Lin-Lin
authors: LL
authors: Mao
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College Xuzhou 221002, China.
authors: Hui
authors: H
authors: Huang
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College Xuzhou 221002, China ; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical College Xuzhou 221002, China.
authors: Jun-Nian
authors: JN
authors: Zheng
authors: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College Xuzhou 221002, China.
authors: Dong-Sheng
authors: DS
authors: Pei
keywords: E-cadherin; RCC; cell invasion; p42.3; β-catenin