title: Serologically Determined Gastric Mucosal Condition Is a Predictive Factor for Osteoporosis in Japanese Men.
abstract: BACKGROUND
  There are few reports about the influence of Helicobacter pylori infection and/or atrophic gastritis on bone conditions in Japan.
  
  
  OBJECTIVE
  To assess whether the combination of serologically determined Helicobacter pylori infection and atrophic gastritis is available as a biomarker for bone conditions.
  
  
  METHODS
  We studied 230 men in their 50s and 60s. Helicobacter pylori infection was determined using serum antibody to this bacterium. Atrophic gastritis was diagnosed on the basis of the serum pepsinogen I and II criteria. The characteristics of the participants' bone were measured at the radius using an ultrasonic bone densitometry system. The risks of low trabecular bone density, low elastic modulus of trabecular bone, and low cortical thickness among subjects who were positive for Helicobacter pylori infection and/or atrophic gastritis relative to those who were not were calculated.
  
  
  RESULTS
  Helicobacter pylori infection significantly increased the risk of low trabecular bone density (odds ratio 1.83, 95 % confidence interval 1.04-3.21, P = 0.03). Atrophic gastritis significantly increased the risk of low trabecular bone density (2.22, 1.17-4.22, 0.01). Compared with anti-Helicobacter pylori antibody (-) and atrophic gastritis (-) subjects, anti-Helicobacter pylori antibody (+) and atrophic gastritis (+) subjects were a significant high-risk group for low trabecular bone density (2.65, 1.27-5.55, 0.01).
  
  
  CONCLUSIONS
  A serological diagnosis of Helicobacter pylori infection and atrophic gastritis, which is utilized for risk assessment of gastric cancer, was suggested to be useful for risk assessment of osteoporosis.
authors: Department of Medical Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyama-kita, Higashinada-ku, Kobe, 658-8558, Japan, mizuno@kobepharma-u.ac.jp.
authors: Shigeto
authors: S
authors: Mizuno
authors: Daisuke
authors: D
authors: Matsui
authors: Isao
authors: I
authors: Watanabe
authors: Etsuko
authors: E
authors: Ozaki
authors: Nagato
authors: N
authors: Kuriyama
authors: Yoshiyuki
authors: Y
authors: Watanabe
mesh_terms: D044466:Asian People; D015519:Bone Density; D005757:Gastritis, Atrophic / Q000150:complications*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*; D012307:Risk Factors