title: Basal metabolic rate in women with PCOS compared to eumenorrheic controls.
abstract: OBJECTIVE
  PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), thereby leading to difficulties in weight loss. The objective of this study is to compare basal metabolic rate (BMR) in women with PCOS and controls.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  One hundred and twenty-eight PCOS patients diagnosed by original NIH consensus criteria and 72 eumenorrheic, non-hirsute controls were recruited from an academic medical centre.
  
  
  METHODS
  Assessment of BMR using the InBody portable bioelectrical impedance analysis (BIA) device and insulin resistance by HOMA-IR indices.
  
  
  RESULTS
  PCOS women were younger than controls. As expected, PCOS subjects had higher body mass index (BMI), serum androgens and estimated insulin resistance. After adjusting for age and BMI, there was no significant difference in BMR between PCOS subjects (adjusted mean 5807 kJ/day, 95% CI 5715-5899) and controls (adjusted mean 5916 kJ/day, 95% CI 5786-6046) (P = 0·193). BMR was also comparable in a secondary analysis comparing PCOS women with and without insulin resistance.
  
  
  CONCLUSIONS
  After adjusting for age and BMI, there was no difference in BMR between PCOS women and controls.
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors: Sara J
authors: SJ
authors: Churchill
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.|Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, David Geffen School of Medicine, University of California, University of California at Los Angeles, Los Angeles, CA, USA.
authors: Erica T
authors: ET
authors: Wang
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors: Gaisu
authors: G
authors: Bhasin
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.|Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, David Geffen School of Medicine, University of California, University of California at Los Angeles, Los Angeles, CA, USA.
authors: Carolyn
authors: C
authors: Alexander
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors: Catherine
authors: C
authors: Bresee
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors: Marita
authors: M
authors: Pall
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.|Departments of Obstetrics and Gynecology, and Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
authors: Ricardo
authors: R
authors: Azziz
authors: Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors: Ruchi
authors: R
authors: Mathur
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.|Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, David Geffen School of Medicine, University of California, University of California at Los Angeles, Los Angeles, CA, USA.
authors: Margareta D
authors: MD
authors: Pisarska
mesh_terms: D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D013739:Testosterone; D011374:Progesterone; D011388:Prolactin; D013972:Thyrotropin