title: Contraceptive studies of isolated fractions of Cuminum cyminum in male albino rats.
abstract: The contraceptive efficacy of Cuminum cyminum isolated fractions (CcFr) in male albino rats was investigated. Oral dose of CcFr at 50 mg/rat/day for 60 days revealed no significant changes in body weight, while marked abnormalities in spermatogenesis were observed with decreased counts (P ≤ 0.001) in round spermatids, preleptotene spermatocytes and secondary spermatocytes. Cross sectional surface area of Sertoli cells as well as number of mature Leydig cell were decreased significantly (P ≤ 0.001). Testicular as well as accessory sex organ biochemical parameters were significantly changed (P ≤ 0.001). Sperm motility, density and morphology were resulted in 100% negative fertility. Testosterone levels were declined significantly. In conclusion, Cuminum cyminum inhibited spermatogenesis in rats, indicating the possibility of developing an herbal male contraceptive.
authors: a Department of Zoology , Reproductive Physiology Section, Centre for Advanced Studies, University of Rajasthan , Jaipur 302 004 , India.
authors: Poonam
authors: P
authors: Saxena
authors: a Department of Zoology , Reproductive Physiology Section, Centre for Advanced Studies, University of Rajasthan , Jaipur 302 004 , India.
authors: Rajnish
authors: R
authors: Gupta
authors: a Department of Zoology , Reproductive Physiology Section, Centre for Advanced Studies, University of Rajasthan , Jaipur 302 004 , India.
authors: R S
authors: RS
authors: Gupta
mesh_terms: D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D028527:Cuminum / Q000737:chemistry*; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012708:Sertoli Cells / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D003272:Contraceptive Agents, Male; D013739:Testosterone
keywords: leydig cells; sertoli cells; sperm morphology; spermatogenesis; testosterone