title: Genetics of rheumatoid arthritis in Asia--present and future.
abstract: Genome-wide association studies (GWAS) have uncovered numerous susceptibility genes for rheumatoid arthritis (RA) in patients of European, Asian and other ethnic ancestries. Although previous transethnic GWAS meta-analyses enabled the identification of several novel loci, the genetic heterogeneity observed in the PADI4 and PTPN22 genes suggests that ethnic variation should be considered. In addition, the effects of genetic polymorphisms on gene expression profiles are important when assessing the association of genetic information with disease pathogenesis and will influence the development of personalized medicine. Gene expression is controlled by epigenetic modifications, which in turn can be affected by environmental stimuli. Altogether, genetic and epigenetic information of Asian populations will contribute considerably to future rheumatology research.
authors: 1] Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan. [2] Laboratory for Autoimmune Diseases, Center for Integrated Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
authors: Kazuhiko
authors: K
authors: Yamamoto
authors: Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
authors: Yukinori
authors: Y
authors: Okada
authors: Laboratory for Autoimmune Diseases, Center for Integrated Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
authors: Akari
authors: A
authors: Suzuki
authors: Laboratory for Autoimmune Diseases, Center for Integrated Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
authors: Yuta
authors: Y
authors: Kochi
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics