title: Revisiting the dyslipidemia associated with acute leukemia.
abstract: BACKGROUND
  Previous studies appreciate the leukemia-associated alterations in plasma lipid profiles but fail to provide a consistent pattern of lipid anomalies in leukemia patients. These inconsistencies could be due to overlooking the effects of related confounding risk-factors and comorbidities.
  
  
  METHODS
  The plasma lipid profiles of acute-leukemia and control groups were compared.
  
  
  RESULTS
  We observed that acute lymphocytic leukemia (ALL) patients display significantly higher triglycerides and very low-density lipoproteins, whereas, acute myeloid leukemia (AML) patients display significantly lower high-density lipoproteins. To assess the confounding effects of related risk factors gender-, age- and BMI-based analyses were performed. We observed that the aforementioned significant differences in the lipid profiles of leukemia patients were restricted to female participants of the respective groups. Moreover, a significant decrease in total cholesterol and low-density lipoprotein levels was observed only in male participants of the AML population. Various age-specific trends in plasma lipid profile of the leukemia patients were also observed. BMI-based analysis did not display many significant differences from the overall analyses. In addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups.
  
  
  CONCLUSIONS
  These findings may help in outlining the prevalence and types of dyslipidemia in leukemia patients that may emerge as diagnostic/prognostic factors for the management of acute leukemia.
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Hina
authors: H
authors: Usman
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Rida
authors: R
authors: Rashid
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Fatima
authors: F
authors: Ameer
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Areeb
authors: A
authors: Iqbal
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Muhammad
authors: M
authors: Zaid
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
authors: Shahida
authors: S
authors: Hasnain
authors: Medical and Natural Sciences Research Centre, University of Tubingen, Germany.
authors: Hubert
authors: H
authors: Kalbacher
authors: Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan. Electronic address: nzzaidi@yahoo.com.
authors: Nousheen
authors: N
authors: Zaidi
mesh_terms: D000293:Adolescent; D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Acute leukemia; Dyslipidemia; Lipoproteins; Plasma lipids; Tumor metabolism