title: Nano-objects for addressing the control of nanoparticle arrangement and performance in magnetic hyperthermia.
abstract: One current challenge of magnetic hyperthermia is achieving therapeutic effects with a minimal amount of nanoparticles, for which improved heating abilities are continuously pursued. However, it is demonstrated here that the performance of magnetite nanocubes in a colloidal solution is reduced by 84% when they are densely packed in three-dimensional arrangements similar to those found in cell vesicles after nanoparticle internalization. This result highlights the essential role played by the nanoparticle arrangement in heating performance, uncontrolled in applications. A strategy based on the elaboration of nano-objects able to confine nanocubes in a fixed arrangement is thus considered here to improve the level of control. The obtained specific absorption rate results show that nanoworms and nanospheres with fixed one- and two-dimensional nanocube arrangements, respectively, succeed in reducing the loss of heating power upon agglomeration, suggesting a change in the kind of nano-object to be used in magnetic hyperthermia.
authors: Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza , Campus Río Ebro, María de Luna 3, 50018 Zaragoza, Spain.
authors: Irene
authors: I
authors: Andreu
authors: Eva
authors: E
authors: Natividad
authors: Laura
authors: L
authors: Solozábal
authors: Olivier
authors: O
authors: Roubeau
mesh_terms: D052203:Ferrosoferric Oxide / Q000737:chemistry; D006979:Hyperthermia, Induced / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D060328:Magnetic Phenomena; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide
keywords: PLGA; iron oxide magnetic nanoparticles; magnetic interactions; nano-object; silica; specific absorption rate