title: Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal.
abstract: Osteosarcoma (OS) is the most common and aggressive primary malignant type of bone cancer in children and adolescents. Chemotherapy is one of the most important treatments for OS. Although cancer therapy has improved over the past few decades, survival outcomes for OS patients remain unsatisfactory. One of the primary reasons for the failure of current treatments is that patients with stage IV cancer often develop resistance to anticancer agents. This article will review multidrug resistance (MDR) mechanisms of OS and strategies for overcoming resistance.
authors: Department of Orthopedics, Shanghai First People's Hospital, Nanjing Medical University, 100 Haining Rd, Shanghai, 200072, China, lisuoyuan4242@163.com.
authors: Suoyuan
authors: S
authors: Li
authors: Wei
authors: W
authors: Sun
authors: Hongsheng
authors: H
authors: Wang
authors: Dongqing
authors: D
authors: Zuo
authors: Yingqi
authors: Y
authors: Hua
authors: Zhengdong
authors: Z
authors: Cai
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents