title: Microsphaerol and seimatorone: two new compounds isolated from the endophytic fungi, Microsphaeropsis sp. and Seimatosporium sp.
abstract: A new polychlorinated triphenyl diether named microsphaerol (1), has been isolated from the endophtic fungus Microsphaeropsis sp. An intensive phytochemical investigation of the endophytic fungus Seimatosporium sp., led to the isolation of a new naphthalene derivative named seimatorone (2) and eight known compounds, i.e., 1-(2,6-dihydroxyphenyl)-3-hydroxybutan-1-one (3), 1-(2,6-dihydroxyphenyl)butan-1-one (4), 1-(2-hydroxy-6-methoxyphenyl)butan-1-one (5), 5-hydroxy-2-methyl-4H-chromen-4-one (6), 2,3-dihydro-5-hydroxy-2-methyl-4H-chromen-4-one (7), 8-methoxynaphthalen-1-ol (8), nodulisporins A and B (9 and 10, resp.), and daldinol (11). The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including (1) H- and (13) C-NMR, COSY, HMQC, HMBC, and HR-EI-MS, while the structures of the known compounds were deduced from comparison of their spectral data with those in the literature. Preliminary studies revealed that microsphaerol (1) showed good antibacterial activities against B. Megaterium and E. coli, and good antilagal and antifungal activities against C. fusca, M. violaceum, respectively. On the other hand, seimatorone (2) exhibited moderate antibacterial, antialgal, and antifungal activities.
authors: Department of Chemistry, University of Paderborn, Warburger Strasse 100, DE-33098 Paderborn, (phone: +49-5251-602172; fax: +49-5251-603245); UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman. Hidayat110@gmail.com.
authors: Hidayat
authors: H
authors: Hussain
authors: Natalia
authors: N
authors: Root
authors: Farah
authors: F
authors: Jabeen
authors: Ahmed
authors: A
authors: Al-Harrasi
authors: Manzoor
authors: M
authors: Ahmad
authors: Fazal
authors: F
authors: Mabood
authors: Zahid
authors: Z
authors: Hassan
authors: Afzal
authors: A
authors: Shah
authors: Ivan R
authors: IR
authors: Green
authors: Barbara
authors: B
authors: Schulz
authors: Karsten
authors: K
authors: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D001410:Bacillus megaterium / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D055768:Halogenated Diphenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D055768:Halogenated Diphenyl Ethers; D009281:Naphthalenes; C000602276:microsphaerol; C000602277:seimatorone
keywords: Antibacterial activity; Antifungal activity; Diether; Endophytic fungi; Microsphaeropsis; Naphthalene-2-carbaldehyde; Seimatosporium