title: Serum interleukin-1β in subjects with abdominal obesity and periodontitis.
abstract: OBJECTIVE
  Abdominal obesity and periodontal diseases are believed to share close relation through commonality of chronic inflammation. Both inflammatory periodontal disease and excess abdominal fat modulate their systemic influences through several inflammatory mediators. The present study was carried out to evaluate and compare serum interleukin-1β levels in subjects with abdominal obesity and periodontal disease.
  
  
  METHODS
  Sixty non-diabetic and non-smoking subjects (aged 25-49 years; 28 females and 32 males) were assessed for abdominal obesity by waist to hip ratio. Full-mouth clinical periodontal measurements were recorded for determination of periodontal status. Serum samples were obtained and interleukin-1β was assessed using commercially available ELISA kit. Obtained data were analyzed statistically.
  
  
  RESULTS
  Measures of abdominal obesity and periodontal disease were found to significantly influence the serum interleukin-1β. Abdominally obese subjects had significantly higher serum interleukin-1β in healthy (p=0.006), gingivitis (p<0.001) and periodontitis (p<0.001) groups. There was a significant difference in serum interleukin-1β levels among subjects with different periodontal status in both non obese (F(2,27)=18.17, p<0.0001) and obese groups (F(2,27)=15.70, p<0.0001). Serum interleukin-1β was significantly correlated with PI, GI, BOP%, PD and CAL non obese and obese groups. A significant correlation was also seen with WC, HC and WHR only in obese group.
  
  
  CONCLUSIONS
  Significant changes in serum interleukin-1β are influenced by abdominal obesity and periodontal status independently even in the absence of diabetes mellitus and smoking. Serum interleukin-1β was significantly higher in patients with abdominal obesity and periodontitis.
authors: Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Khandagiri Square, Bhubaneswar 751003, Odisha, India. Electronic address: drasatpathy@gmail.com.
authors: Anurag
authors: A
authors: Satpathy
authors: Department of Periodontics, Sri Hasanamba Dental College & Hospital, Vidya Nagar, Hassan 573201, Karnataka, India.
authors: Shivamurthy
authors: S
authors: Ravindra
authors: Department of Periodontics and Oral Implantology, SDM College of Dental Sciences & Hospital, Sattur, Dharwad 580009, Karnataka, India.
authors: Srinath
authors: S
authors: Thakur
authors: Department of Periodontics and Oral Implantology, SDM College of Dental Sciences & Hospital, Sattur, Dharwad 580009, Karnataka, India.
authors: Sudhindra
authors: S
authors: Kulkarni
authors: Department of Prosthetic Dentistry, College of Dentistry, Jazan University, Jazan, Postal Code 45142, Saudi Arabia.
authors: Amit
authors: A
authors: Porwal
authors: Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Khandagiri Square, Bhubaneswar 751003, Odisha, India.
authors: Saurav
authors: S
authors: Panda
mesh_terms: D050153:Abdominal Fat; D000328:Adult; D005260:Female; D005891:Gingivitis / Q000097:blood* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000473:pathology; D010518:Periodontitis / Q000097:blood* / Q000473:pathology; D012016:Reference Values; D049629:Waist-Hip Ratio
chemical_list: D053583:Interleukin-1beta
keywords: Abdominal obesity; Hip circumference; Interleukin-1β; Periodontitis; Waist circumference