title: Probabilistic predictive modelling of carbon nanocomposites for medical implants design.
abstract: Modelling of the mechanical properties of carbon nanocomposites based on input variables like percentage weight of Carbon Nanotubes (CNT) inclusions is important for the design of medical implants and other structural scaffolds. Current constitutive models for the mechanical properties of nanocomposites may not predict well due to differences in conditions, fabrication techniques and inconsistencies in reagents properties used across industries and laboratories. Furthermore, the mechanical properties of the designed products are not deterministic, but exist as a probabilistic range. A predictive model based on a modified probabilistic surface response algorithm is proposed in this paper to address this issue. Tensile testing of three groups of different CNT weight fractions of carbon nanocomposite samples displays scattered stress-strain curves, with the instantaneous stresses assumed to vary according to a normal distribution at a specific strain. From the probabilistic density function of the experimental data, a two factors Central Composite Design (CCD) experimental matrix based on strain and CNT weight fraction input with their corresponding stress distribution was established. Monte Carlo simulation was carried out on this design matrix to generate a predictive probabilistic polynomial equation. The equation and method was subsequently validated with more tensile experiments and Finite Element (FE) studies. The method was subsequently demonstrated in the design of an artificial tracheal implant. Our algorithm provides an effective way to accurately model the mechanical properties in implants of various compositions based on experimental data of samples.
authors: Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore. Electronic address: a0045789@nus.edu.sg.
authors: Matthew
authors: M
authors: Chua
authors: Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore. Electronic address: CheeKong.Chui.C@ieee.org.
authors: Chee-Kong
authors: CK
authors: Chui
mesh_terms: D000465:Algorithms; D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D008422:Materials Testing; D055595:Mechanical Phenomena; D015233:Models, Statistical; D053761:Nanocomposites; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D037742:Nanotubes, Carbon; C013830:baysilon
keywords: Artificial tracheal implant; Carbon nanocomposites; Probabilistic modelling; Response surface methodology