title: Retromer in Alzheimer disease, Parkinson disease and other neurological disorders.
abstract: Retromer is a protein assembly that has a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders. First linked to Alzheimer disease, retromer dysfunction causes a range of pathophysiological consequences that have been shown to contribute to the core pathological features of the disease. Genetic studies have established that retromer dysfunction is also pathogenically linked to Parkinson disease, although the biological mechanisms that mediate this link are only now being elucidated. Most recently, studies have shown that retromer is a tractable target in drug discovery for these and other disorders of the nervous system.
authors: Taub Institute for Research on Alzheimer's Disease and the Ageing Brain, Departments of Neurology, Radiology, and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
authors: Scott A
authors: SA
authors: Small
authors: Helen and Robert Appel Alzheimer's Disease Research Institute, Department of Neurology and Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York 10065, USA.
authors: Gregory A
authors: GA
authors: Petsko
mesh_terms: D034001:Adaptor Protein Complex Subunits / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D021381:Protein Transport / Q000502:physiology
chemical_list: D034001:Adaptor Protein Complex Subunits