title: Is primary tumor detectable in prostatic carcinoma at routine contrast-enhanced CT?
abstract: OBJECTIVE
  To determine if prostatic carcinoma (PCa) is detectable at routine contrast-enhanced CT (CECT).
  
  
  METHODS
  With institutional review board approval, 63 consecutive PCa patients underwent CECT before therapy. Two blinded radiologists assessed for rounded focal enhancing peripheral zone nodules. Diagnostic accuracy and inter-observer agreement were compared by Gleason Score (GS).
  
  
  RESULTS
  Overall sensitivity was 63-76% with moderate agreement, K=0.42. The false-positive rate was 15%. Sensitivities and agreement for GS 9-10, 7-8 and 6 PCa were 84-91%, 73-84%, 41-71%, (P=.023 and .001) and K=(0.72, 0.69, 0.23).
  
  
  CONCLUSIONS
  CECT has good sensitivity for detecting GS ≥7 PCa with substantial agreement and a low false-positive rate.
authors: The Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9. Electronic address: nschieda@toh.on.ca.
authors: Nicola
authors: N
authors: Schieda
authors: The Ottawa Hospital, The University of Ottawa, Department of Radiology, Civic Campus C1, 1053 Carling Avenue; Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: omdan2@gmail.com.
authors: Omran
authors: O
authors: Al-Dandan
authors: The Ottawa Hospital, The University of Ottawa, Department of Radiology, Civic Campus C1, 1053 Carling Avenue; Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: wshabana@toh.on.ca.
authors: Wael
authors: W
authors: Shabana
authors: The Ottawa Hospital, The University of Ottawa, Department of Anatomical Pathology, 501 Smyth Road, 4th floor CCW, Room 4278; Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: tflood@toh.on.ca.
authors: Trevor A
authors: TA
authors: Flood
authors: The Ottawa Hospital, The University of Ottawa, Department of Radiation Oncology, 501 Smyth Road, Cancer Care Wing; Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: smalone@ottawahospital.on.ca.
authors: Shawn C
authors: SC
authors: Malone
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: Computed tomography; Gleason Score; Prostate cancer; RECIST; Staging