title: Should we use platelet-rich plasma as an adjunct therapy to treat "acute wounds," "burns," and "laser therapies": A review and a proposal of a quality criteria checklist for further studies.
abstract: Platelet-rich plasma seems to help wound healing. The goal of this review is to determine if the adjunction of platelet-rich plasma enhances the clinical outcome of acute wounds, burns, and laser therapies. A PubMed and Cochrane library search was performed by two reviewers with the senior author as a consultant. Medical Subject Headings search terms used were the following: ["Platelet-rich plasma" OR "Platelet gel" OR "Platelet growth factor"] AND ["Acute wound" OR "Wound" OR "Burn" OR "Laser"]. We included controlled studies assessing the clinical outcome of acute wounds, burns, and laser therapies treated by platelet-rich plasma. Nine randomized controlled studies, six prospective controlled studies, and two retrospective controlled studies were included. Regarding acute wounds, three randomized controlled trials found a statistical benefit regarding either the healing time, the return back to work time, the quality of life, or the pain and three prospective controlled studies found a statistical difference regarding the velocity of healing. Platelet-rich plasma decreased the intensity or duration of erythema after laser therapy in four randomized studies. Regarding the long-term outcome of laser therapies, two studies found a statistical benefit and two others did not. Platelet-rich plasma accelerates acute wound healing and decreases erythema after laser therapies. Its use on burns has not been enough studied.
authors: Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital, Creteil, France.
authors: Frédéric
authors: F
authors: Picard
authors: Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital, Creteil, France.
authors: Barbara
authors: B
authors: Hersant
authors: Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital, Creteil, France.
authors: Romain
authors: R
authors: Bosc
authors: Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital, Creteil, France.
authors: Jean-Paul
authors: JP
authors: Meningaud
mesh_terms: D001804:Blood Transfusion, Autologous; D002056:Burns / Q000473:pathology / Q000628:therapy*; D057189:Checklist; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D017713:Platelet Transfusion; D053657:Platelet-Rich Plasma; D003668:Pressure Ulcer / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D011785:Quality Assurance, Health Care; D011788:Quality of Life; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing