title: Phylogenomic characterization of California sea lion adenovirus-1.
abstract: Significant adenoviral diversity has been found in humans, but in domestic and wild animals the number of identified viruses is lower. Here we present the complete genome of a recently discovered mastadenovirus, California sea lion adenovirus 1 (CSLAdV-1) isolated from California sea lions (Zalophus californianus), an important pathogen associated with hepatitis in pinnipeds. The genome of this virus has the typical mastadenoviral structure with some notable differences at the carboxy-terminal end, including a dUTPase that does not cluster with other mastadenoviral dUTPases, and a fiber that shows similarity to a trans-sialidase of Trypanosoma cruzi and choline-binding protein A (CbpA) of Streptococcus pneumoniae. The GC content is low (36%), and phylogenetic analyses placed the virus near the root of the clade infecting laurasiatherian hosts in the genus Mastadenovirus. These findings support the hypothesis that CSLAdV-1 in California sea lions represents a host jump from an unknown mammalian host in which it is endemic.
authors: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors: Galaxia
authors: G
authors: Cortés-Hinojosa
authors: The Marine Mammal Center, Sausalito, CA, USA.
authors: Frances M D
authors: FM
authors: Gulland
authors: Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA, USA.
authors: Tracey
authors: T
authors: Goldstein
authors: National Marine Mammal Foundation, San Diego, CA, USA.
authors: Stephanie
authors: S
authors: Venn-Watson
authors: Hubbs-SeaWorld Research Institute, 2595 Ingraham St., San Diego, CA, USA.
authors: Rebecca
authors: R
authors: Rivera
authors: Department of Infectious Diseases and Pathology, College of Veterinary Medicine University of Florida, Gainesville, FL, USA.
authors: Thomas B
authors: TB
authors: Waltzek
authors: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
authors: Marco
authors: M
authors: Salemi
authors: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. Electronic address: wellehanj@ufl.edu.
authors: James F X
authors: JF
authors: Wellehan
mesh_terms: D000256:Adenoviridae / Q000145:classification* / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D023061:Gene Order; D016679:Genome, Viral; D016366:Open Reading Frames; D010802:Phylogeny; D046070:Sea Lions / Q000821:virology*; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
keywords: Adenovirus; California sea lion; Genome; Mastadenovirus; Phylogeny; Zalophus californianus