title: Asymmetric organocatalytic synthesis of quaternary α-hydroxy phosphonates: en route to α-aryl phosphaisoserines.
abstract: The dual activation of acyl phosphonates and formaldehyde tert-butyl hydrazone by a BINAM-derived bis-urea catalyst is the key to achieve high reactivities and enantioselectivities in the synthesis of densely functionalized quaternary α-hydroxy phosphonates. Subsequent high-yielding transformations in a 'one-pot' fashion provide direct access to valuable azoxy compounds and quaternary α-aryl-phosphaisoserines.
authors: Departamento de Química Orgánica, Universidad de Sevilla, C/ Prof. García González, 1, 41012 Sevilla, Spain. dmonge@us.es ffernan@us.es.
authors: Inmaculada
authors: I
authors: Serrano
authors: David
authors: D
authors: Monge
authors: Eleuterio
authors: E
authors: Álvarez
authors: Rosario
authors: R
authors: Fernández
authors: José M
authors: JM
authors: Lassaletta
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D005557:Formaldehyde / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D012694:Serine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D014508:Urea / Q000737:chemistry
chemical_list: D063065:Organophosphonates; D005557:Formaldehyde; D012694:Serine; C072421:isoserine; D014508:Urea