title: [Effects of nuclear factor of kappa B decoy oligodeoxynucleotides on murine with multiple myeloma].
abstract: OBJECTIVE
  The present study was to evaluate the effects of nuclear factor of kappa B decoy oligodeoxynucleotides on murine multiple myeloma models.
  
  
  METHODS
  The severe combined immunodeficient mice were injected subcutaneously with RPMI-8226 myeloma cells. When tumors became measurable, the mice were divided into 2 treatment groups who respectively received 5 µg/g or 10 µg/g liposome-NF-κB decoy ODN compounds, and one control group was selected; the control group received 10 µg/g liposome-NF-κB mutant decoy ODN compounds, twice per week for 4 weeks. The mice were killed when they died or the tumor diameter became >2 cm.
  
  
  RESULTS
  The liposome-NF-κB decoy ODN could efficiently suppress NF-κB DNA binding activity and inhibited the expression of IL-6. As compared with the control group, the two liposome-NF-κB decoy ODN-treated groups showed more remarkably survival time and smaller tumor volume.
  
  
  CONCLUSIONS
  In vivo transfection of NF-κB decoy ODN may provide a new therapeutic strategy for multiple myeloma.
authors: Department of Blood Purification, Kidney Disease Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors: Ke-Hui
authors: KH
authors: Shi
authors: Department of Blood Purification, Kidney Disease Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. E-mail:j92106@sina.com.
authors: Hong-Li
authors: HL
authors: Jiang
mesh_terms: D000818:Animals; D004247:DNA; D004195:Disease Models, Animal; D015316:Genetic Therapy; D015850:Interleukin-6; D008081:Liposomes; D051379:Mice; D009101:Multiple Myeloma; D009838:Oligodeoxyribonucleotides; D014162:Transfection
chemical_list: D015850:Interleukin-6; D008081:Liposomes; C468119:NF-kappaB decoy; D009838:Oligodeoxyribonucleotides; D004247:DNA