title: Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.
abstract: Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
authors: Department of Chemistry, North Caucasus Federal University , 1a Pushkin St., Stavropol 355009, Russian Federation.
authors: Alexander V
authors: AV
authors: Aksenov
authors: Alexander N
authors: AN
authors: Smirnov
authors: Igor V
authors: IV
authors: Magedov
authors: Mary R
authors: MR
authors: Reisenauer
authors: Nicolai A
authors: NA
authors: Aksenov
authors: Inna V
authors: IV
authors: Aksenova
authors: Alexander L
authors: AL
authors: Pendleton
authors: Gina
authors: G
authors: Nguyen
authors: Robert K
authors: RK
authors: Johnston
authors: Michael
authors: M
authors: Rubin
authors: Annelise
authors: A
authors: De Carvalho
authors: Robert
authors: R
authors: Kiss
authors: Véronique
authors: V
authors: Mathieu
authors: Florence
authors: F
authors: Lefranc
authors: Jaime
authors: J
authors: Correa
authors: David A
authors: DA
authors: Cavazos
authors: Andrew J
authors: AJ
authors: Brenner
authors: Brad A
authors: BA
authors: Bryan
authors: Snezna
authors: S
authors: Rogelj
authors: Alexander
authors: A
authors: Kornienko
authors: Liliya V
authors: LV
authors: Frolova
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D007211:Indoles