title: Synthesis and structure-activity relationship studies of furan-ring fused chalcones as antiproliferative agents.
abstract: As part of our continuing investigation of flavonoid derivatives as potential anticancer substances, the synthesis of 25 cinnamoyl derivatives of benzofuran as furan-fused chalcones was carried-out and these compounds were further evaluated for their antiproliferative activity towards HL60 promyelocytic leukemia cells. In comparison with 2',4'-dihydroxychalcone, attachment of a furan moiety on the A-ring enhanced activity by more than twofold. Benzofurans may be useful in the design of biologically active flavonoids.
authors: Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama, Japan.
authors: Yusuke
authors: Y
authors: Saito
authors: Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama, Japan.
authors: Maho
authors: M
authors: Kishimoto
authors: Laboratory of Bio-organic Chemistry, Akita Prefectural University, Akita, Japan.
authors: Yuko
authors: Y
authors: Yoshizawa
authors: Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama, Japan kawaii@mail.dendai.ac.jp.
authors: Satoru
authors: S
authors: Kawaii
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D066244:Proton Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones
keywords: Furochalcones; HL60 cells; antiproliferative activity; structure and activity relationship