title: Milestones of Lynch syndrome: 1895-2015.
abstract: Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.
authors: Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA.
authors: Henry T
authors: HT
authors: Lynch
authors: Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA.
authors: Carrie L
authors: CL
authors: Snyder
authors: Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA.
authors: Trudy G
authors: TG
authors: Shaw
authors: Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-3101, USA.
authors: Christopher D
authors: CD
authors: Heinen
authors: Department of Medicine (Oncology), Stanford Cancer Institute, Stanford University, Grant Building S169, 1291 Welch Road, Stanford, California 94305, USA.
authors: Megan P
authors: MP
authors: Hitchins
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000266:history* / Q000628:therapy; D053843:DNA Mismatch Repair / Q000235:genetics; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century