title: Colorectal cancer in iran: molecular epidemiology and screening strategies.
abstract: Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in Iran has made it a major public health burden. This study aimed to report its epidemiologic features, molecular genetic aspects, survival, heredity, and screening pattern in Iran. Methods. A comprehensive literature review was conducted to identify the relevant published articles. We used medical subject headings, including colorectal cancer, molecular genetics, KRAS and BRAF mutations, screening, survival, epidemiologic study, and Iran. Results. Age standardized incidence rate of Iranian CRCs was 11.6 and 10.5 for men and women, respectively. Overall five-year survival rate was 41%, and the proportion of CRC among the younger age group was higher than that of western countries. Depending on ethnicity, geographical region, dietary, and genetic predisposition, mutation genes were considerably diverse and distinct among CRCs across Iran. The high occurrence of CRC in records of relatives of CRC patients showed that family history of CRC was more common among young CRCs. Conclusion. Appropriate screening strategies for CRC which is amenable to early detection through screening, especially in relatives of CRCs, should be considered as the first step in CRC screening programs.
authors: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Roya
authors: R
authors: Dolatkhah
authors: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohammad Hossein
authors: MH
authors: Somi
authors: Center of Excellent for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
authors: Mortaza Jabbarpour
authors: MJ
authors: Bonyadi
authors: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Iraj
authors: I
authors: Asvadi Kermani
authors: Department of Medicine, The University of Kansas Medical School, Molecular Medicine Laboratory, KUMC, Kansas City, KS, USA.
authors: Faris
authors: F
authors: Farassati
authors: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Saeed
authors: S
authors: Dastgiri