title: Sarcoidosis and lymphoma: a comparative study.
abstract: OBJECTIVE
  To assess the clinical features and outcome of lymphoma when associated with sarcoidosis and to determine whether this association gives lymphoma a better prognosis.
  
  
  METHODS
  Multicentre retrospective cohort study.
  
  
  METHODS
  Retrospective chart review.
  
  
  RESULTS
  Twenty-one patients were included (9 males, 12 females). Median age at sarcoidosis diagnosis was 48 years (range: 24-68 years). In 14 cases, lymphoma occurred within a previously known sarcoidosis. Five patients received a concomitant diagnosis of sarcoidosis and lymphoma, whereas lymphoma preceded sarcoidosis in two patients. Three patients were diagnosed with Hodgkin's lymphoma and 18 patients with non-Hodgkin's lymphoma (diffuse large B-cell lymphoma (DLBCL) (n = 11), follicular lymphoma (n = 2), chronic lymphocytic leukemia/small lymphocytic lymphoma (n = 2), anaplastic large cell lymphoma ALK + (n = 1), angioimmunoblastic T-cell lymphoma (n = 1) and T-cell prolymphocytic leukemia (n = 1)). Thirteen patients were alive and in complete remission. Median age at the time of diagnosis of sarcoidosis was lower in patients with concomitant lymphoma compared with patients with sarcoidosis preceding lymphoma (34 years vs. 51 years, P = 0.01). Patients presenting with DLBCL associated with sarcoidosis were compared with DLBCL without sarcoidosis. No statistical difference was found in the risk of death or progression between the two groups (P = 0.685).
  
  
  CONCLUSIONS
  We report here the largest series of lymphoma associated sarcoidosis patients. As opposed to previous studies, we observed a predominance of patients with DLBCL. Our study confirms the concept of the sarcoidosis-lymphoma syndrome. Large B-cell lymphoma does not have a better prognosis when associated with sarcoidosis.
authors: From the Service de Médecine Interne, Hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Etienne Cedex 2, France, chalayer@chu-st-etienne.fr.
authors: É
authors: É
authors: Chalayer
authors: Service d'Hématologie, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69495 Pierre Bénite, France.
authors: E
authors: E
authors: Bachy
authors: Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon, 162 Avenue Lacassagne, 69424 Lyon Cedex 3, France.
authors: P
authors: P
authors: Occelli
authors: Service de Dermatologie, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69495 Pierre Bénite, France.
authors: L
authors: L
authors: Weiler
authors: Centre Léon Berard, 28 Promenade Léa et Napoléon Bullukian, 69008 Lyon, France.
authors: P
authors: P
authors: Faurie
authors: Centre Léon Berard, 28 Promenade Léa et Napoléon Bullukian, 69008 Lyon, France.
authors: H
authors: H
authors: Ghesquieres
authors: Service d'Hémato-oncologie, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12 Avenue Nord, Sherbooke QC J1H 5N4, Canada and.
authors: M
authors: M
authors: Pavic
authors: Service de Médecine Interne, Groupement Hospitalier Nord, Hôpital de la Croix Rousse,103 Grande-Rue de la Croix-Rousse 69317 Lyon, France.
authors: C
authors: C
authors: Broussolle
authors: Service de Médecine Interne, Groupement Hospitalier Nord, Hôpital de la Croix Rousse,103 Grande-Rue de la Croix-Rousse 69317 Lyon, France.
authors: P
authors: P
authors: Sève
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D013256:Steroids