title: Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
abstract: Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.
authors: Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK.
authors: Naila
authors: N
authors: Rabbani
authors: Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK. Electronic address: P.J.Thornalley@warwick.ac.uk.
authors: Paul J
authors: PJ
authors: Thornalley
mesh_terms: D000375:Aging / Q000378:metabolism*; D000447:Aldehydes / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D006037:Glyoxal / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D008954:Models, Biological; D018384:Oxidative Stress; D011765:Pyruvaldehyde / Q000378:metabolism; D013312:Stress, Physiological
chemical_list: D000447:Aldehydes; D006037:Glyoxal; D011765:Pyruvaldehyde; D003847:Deoxyglucose; C016350:3-deoxyglucosone
keywords: Cardiovascular disease; Diabetes; Glycation; Hypoxia; Inflammation; Oxidative stress