title: New genetic loci link adipose and insulin biology to body fat distribution.
abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
authors: Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.|Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.|Department of Odontology, Umeå University, Umeå 901 85, Sweden.
authors: Dmitry
authors: D
authors: Shungin
authors: Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
authors: Thomas W
authors: TW
authors: Winkler
authors: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors: Damien C
authors: DC
authors: Croteau-Chonka
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors: Teresa
authors: T
authors: Ferreira
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Adam E
authors: AE
authors: Locke
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Reedik
authors: R
authors: Mägi
authors: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Rona J
authors: RJ
authors: Strawbridge
authors: Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.|Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.|Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.
authors: Tune H
authors: TH
authors: Pers
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Krista
authors: K
authors: Fischer
authors: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Anne E
authors: AE
authors: Justice
authors: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors: Tsegaselassie
authors: T
authors: Workalemahu
authors: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
authors: Joseph M W
authors: JMW
authors: Wu
authors: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Martin L
authors: ML
authors: Buchkovich
authors: National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.|Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
authors: Nancy L
authors: NL
authors: Heard-Costa
authors: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Tamara S
authors: TS
authors: Roman
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors: Alexander W
authors: AW
authors: Drong
authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Ci
authors: C
authors: Song
authors: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Stefan
authors: S
authors: Gustafsson
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Felix R
authors: FR
authors: Day
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.|Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors: Tonu
authors: T
authors: Esko
authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Tove
authors: T
authors: Fall
authors: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.|Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.|Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.
authors: Zoltán
authors: Z
authors: Kutalik
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Jian'an
authors: J
authors: Luan
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
authors: Joshua C
authors: JC
authors: Randall
authors: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.|Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
authors: André
authors: A
authors: Scherag
authors: Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.
authors: Sailaja
authors: S
authors: Vedantam
authors: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
authors: Andrew R
authors: AR
authors: Wood
authors: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
authors: Jin
authors: J
authors: Chen
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Rudolf
authors: R
authors: Fehrmann
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Juha
authors: J
authors: Karjalainen
authors: Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
authors: Bratati
authors: B
authors: Kahali
authors: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
authors: Ching-Ti
authors: CT
authors: Liu
authors: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
authors: Ellen M
authors: EM
authors: Schmidt
authors: HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
authors: Devin
authors: D
authors: Absher
authors: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
authors: Najaf
authors: N
authors: Amin
authors: Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia.
authors: Denise
authors: D
authors: Anderson
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: Marian
authors: M
authors: Beekman
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.|Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI 48109.
authors: Jennifer L
authors: JL
authors: Bragg-Gresham
authors: Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA.|Department of Genetics, Rutgers University, Piscataway, NJ USA.
authors: Steven
authors: S
authors: Buyske
authors: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.|Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.
authors: Ayse
authors: A
authors: Demirkan
authors: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
authors: Georg B
authors: GB
authors: Ehret
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Mary F
authors: MF
authors: Feitosa
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
authors: Anuj
authors: A
authors: Goel
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Anne U
authors: AU
authors: Jackson
authors: Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.|Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.|University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne 1005, Switzerland.
authors: Toby
authors: T
authors: Johnson
authors: Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.|Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Marcus E
authors: ME
authors: Kleber
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Kati
authors: K
authors: Kristiansson
authors: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors: Massimo
authors: M
authors: Mangino
authors: Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
authors: Irene Mateo
authors: IM
authors: Leach
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Carolina
authors: C
authors: Medina-Gomez
authors: Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.
authors: Cameron D
authors: CD
authors: Palmer
authors: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
authors: Dorota
authors: D
authors: Pasko
authors: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
authors: Sonali
authors: S
authors: Pechlivanis
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Marjolein J
authors: MJ
authors: Peters
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.|Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
authors: Inga
authors: I
authors: Prokopenko
authors: University of Eastern Finland, FI-70210 Kuopio, Finland.
authors: Alena
authors: A
authors: Stančáková
authors: Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Yun Ju
authors: YJ
authors: Sung
authors: Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA.
authors: Toshiko
authors: T
authors: Tanaka
authors: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
authors: Alexander
authors: A
authors: Teumer
authors: Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
authors: Jana V
authors: JV
authors: Van Vliet-Ostaptchouk
authors: CNRS UMR 8199, F-59019 Lille, France.|European Genomic Institute for Diabetes, F-59000 Lille, France.|Université de Lille 2, F-59000 Lille, France.
authors: Loïc
authors: L
authors: Yengo
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
authors: Weihua
authors: W
authors: Zhang
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
authors: Eva
authors: E
authors: Albrecht
authors: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.|School of Health and Social Studies, Dalarna University, Falun, Sweden.
authors: Johan
authors: J
authors: Ärnlöv
authors: PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.
authors: Gillian M
authors: GM
authors: Arscott
authors: Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
authors: Stefania
authors: S
authors: Bandinelli
authors: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
authors: Amy
authors: A
authors: Barrett
authors: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.|Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
authors: Claire
authors: C
authors: Bellis
authors: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
authors: Amanda J
authors: AJ
authors: Bennett
authors: Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden.
authors: Christian
authors: C
authors: Berne
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.|Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany.
authors: Matthias
authors: M
authors: Blüher
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: Stefan
authors: S
authors: Böhringer
authors: Inserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France.
authors: Fabrice
authors: F
authors: Bonnet
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
authors: Yvonne
authors: Y
authors: Böttcher
authors: LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Marcel
authors: M
authors: Bruinenberg
authors: USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
authors: Delia B
authors: DB
authors: Carba
authors: Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Ida H
authors: IH
authors: Caspersen
authors: Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
authors: Robert
authors: R
authors: Clarke
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: E Warwick
authors: EW
authors: Daw
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: Joris
authors: J
authors: Deelen
authors: Information Sciences Institute, University of Southern California, Marina del Rey, California, USA.
authors: Ewa
authors: E
authors: Deelman
authors: Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
authors: Graciela
authors: G
authors: Delgado
authors: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
authors: Alex Sf
authors: AS
authors: Doney
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Niina
authors: N
authors: Eklund
authors: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors: Michael R
authors: MR
authors: Erdos
authors: Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.|Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors: Karol
authors: K
authors: Estrada
authors: CNRS UMR 8199, F-59019 Lille, France.|European Genomic Institute for Diabetes, F-59000 Lille, France.|Université de Lille 2, F-59000 Lille, France.
authors: Elodie
authors: E
authors: Eury
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
authors: Nele
authors: N
authors: Friedrich
authors: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
authors: Melissa E
authors: ME
authors: Garcia
authors: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden.
authors: Vilmantas
authors: V
authors: Giedraitis
authors: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
authors: Bruna
authors: B
authors: Gigante
authors: Kaiser Permanente, Division of Research, Oakland, CA 94612, USA.
authors: Alan S
authors: AS
authors: Go
authors: Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland.
authors: Alain
authors: A
authors: Golay
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|German Center for Diabetes Research (DZD), Neuherberg, Germany.
authors: Harald
authors: H
authors: Grallert
authors: Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
authors: Tanja B
authors: TB
authors: Grammer
authors: Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
authors: Jürgen
authors: J
authors: Gräßler
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
authors: Jagvir
authors: J
authors: Grewal
authors: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
authors: Christopher J
authors: CJ
authors: Groves
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Toomas
authors: T
authors: Haller
authors: Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden.
authors: Goran
authors: G
authors: Hallmans
authors: Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Catharina A
authors: CA
authors: Hartman
authors: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
authors: Maija
authors: M
authors: Hassinen
authors: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK.
authors: Caroline
authors: C
authors: Hayward
authors: Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Kauko
authors: K
authors: Heikkilä
authors: Institute of Biomedicine, University of Oulu, Oulu, Finland.|Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland.|Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.
authors: Karl-Heinz
authors: KH
authors: Herzig
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.|Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands.
authors: Quinta
authors: Q
authors: Helmer
authors: Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.|Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Hans L
authors: HL
authors: Hillege
authors: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
authors: Oddgeir
authors: O
authors: Holmen
authors: Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA.
authors: Steven C
authors: SC
authors: Hunt
authors: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.|Center for Medical Sytems Biology, Leiden, The Netherlands.
authors: Aaron
authors: A
authors: Isaacs
authors: Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
authors: Till
authors: T
authors: Ittermann
authors: Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.|School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia.
authors: Alan L
authors: AL
authors: James
authors: Department of Odontology, Umeå University, Umeå 901 85, Sweden.
authors: Ingegerd
authors: I
authors: Johansson
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors: Thorhildur
authors: T
authors: Juliusdottir
authors: Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
authors: Ioanna-Panagiota
authors: IP
authors: Kalafati
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Leena
authors: L
authors: Kinnunen
authors: Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Wolfgang
authors: W
authors: Koenig
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
authors: Ishminder K
authors: IK
authors: Kooner
authors: Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Wolfgang
authors: W
authors: Kratzer
authors: Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria.
authors: Claudia
authors: C
authors: Lamina
authors: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
authors: Karin
authors: K
authors: Leander
authors: USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
authors: Nanette R
authors: NR
authors: Lee
authors: Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
authors: Peter
authors: P
authors: Lichtner
authors: Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Lars
authors: L
authors: Lind
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Jaana
authors: J
authors: Lindström
authors: CNRS UMR 8199, F-59019 Lille, France.|European Genomic Institute for Diabetes, F-59000 Lille, France.|Université de Lille 2, F-59000 Lille, France.
authors: Stéphane
authors: S
authors: Lobbens
authors: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
authors: Mattias
authors: M
authors: Lorentzon
authors: Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
authors: François
authors: F
authors: Mach
authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
authors: Patrik Ke
authors: PK
authors: Magnusson
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors: Anubha
authors: A
authors: Mahajan
authors: School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
authors: Wendy L
authors: WL
authors: McArdle
authors: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors: Cristina
authors: C
authors: Menni
authors: Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Sigrun
authors: S
authors: Merger
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
authors: Evelin
authors: E
authors: Mihailov
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Lili
authors: L
authors: Milani
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
authors: Rebecca
authors: R
authors: Mills
authors: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.|Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK.
authors: Alireza
authors: A
authors: Moayyeri
authors: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.|The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA.
authors: Keri L
authors: KL
authors: Monda
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: Simon P
authors: SP
authors: Mooijaart
authors: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.|Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Thomas W
authors: TW
authors: Mühleisen
authors: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
authors: Antonella
authors: A
authors: Mulas
authors: Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
authors: Gabriele
authors: G
authors: Müller
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.|Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.
authors: Martina
authors: M
authors: Müller-Nurasyid
authors: Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
authors: Ramaiah
authors: R
authors: Nagaraja
authors: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Michael A
authors: MA
authors: Nalls
authors: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors: Narisu
authors: N
authors: Narisu
authors: Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
authors: Nicola
authors: N
authors: Glorioso
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Ilja M
authors: IM
authors: Nolte
authors: Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
authors: Matthias
authors: M
authors: Olden
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
authors: Nigel W
authors: NW
authors: Rayner
authors: Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
authors: Frida
authors: F
authors: Renstrom
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
authors: Janina S
authors: JS
authors: Ried
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
authors: Neil R
authors: NR
authors: Robertson
authors: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
authors: Lynda M
authors: LM
authors: Rose
authors: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
authors: Serena
authors: S
authors: Sanna
authors: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
authors: Hubert
authors: H
authors: Scharnagl
authors: LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Salome
authors: S
authors: Scholtens
authors: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.|Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
authors: Bengt
authors: B
authors: Sennblad
authors: Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Thomas
authors: T
authors: Seufferlein
authors: Department of Medicine, University of Washington, Seattle, WA 98101, USA.
authors: Colleen M
authors: CM
authors: Sitlani
authors: Icelandic Heart Association, Kopavogur 201, Iceland.|University of Iceland, Reykjavik 101, Iceland.
authors: Albert Vernon
authors: AV
authors: Smith
authors: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.|William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK.
authors: Kathleen
authors: K
authors: Stirrups
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Heather M
authors: HM
authors: Stringham
authors: Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Johan
authors: J
authors: Sundström
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Morris A
authors: MA
authors: Swertz
authors: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors: Amy J
authors: AJ
authors: Swift
authors: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden.
authors: Ann-Christine
authors: AC
authors: Syvänen
authors: Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA.
authors: Bamidele O
authors: BO
authors: Tayo
authors: German Center for Diabetes Research (DZD), Neuherberg, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany.
authors: Barbara
authors: B
authors: Thorand
authors: deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
authors: Gudmar
authors: G
authors: Thorleifsson
authors: Department of Cardiology, Medical University of Graz, Graz 8036, Austria.
authors: Andreas
authors: A
authors: Tomaschitz
authors: Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
authors: Chiara
authors: C
authors: Troffa
authors: Department of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands.
authors: Floor Va
authors: FV
authors: van Oort
authors: Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
authors: Niek
authors: N
authors: Verweij
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Judith M
authors: JM
authors: Vonk
authors: HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
authors: Lindsay L
authors: LL
authors: Waite
authors: Department of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Roman
authors: R
authors: Wennauer
authors: Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
authors: Tom
authors: T
authors: Wilsgaard
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Mary K
authors: MK
authors: Wojczynski
authors: MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
authors: Andrew
authors: A
authors: Wong
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Qunyuan
authors: Q
authors: Zhang
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Jing Hua
authors: JH
authors: Zhao
authors: Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
authors: Eoin P
authors: EP
authors: Brennan
authors: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
authors: Murim
authors: M
authors: Choi
authors: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Per
authors: P
authors: Eriksson
authors: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Lasse
authors: L
authors: Folkersen
authors: Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Anders
authors: A
authors: Franco-Cereceda
authors: Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA.
authors: Ali G
authors: AG
authors: Gharavi
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Åsa K
authors: ÅK
authors: Hedman
authors: Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA.|Massachusetts General Hospital, Boston, MA, USA.
authors: Marie-France
authors: MF
authors: Hivert
authors: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
authors: Jinyan
authors: J
authors: Huang
authors: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK.
authors: Stavroula
authors: S
authors: Kanoni
authors: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.|NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK.
authors: Fredrik
authors: F
authors: Karpe
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
authors: Sarah
authors: S
authors: Keildson
authors: Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA.
authors: Krzysztof
authors: K
authors: Kiryluk
authors: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, MA 2115, USA.
authors: Liming
authors: L
authors: Liang
authors: Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA.
authors: Richard P
authors: RP
authors: Lifton
authors: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.|College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China.
authors: Baoshan
authors: B
authors: Ma
authors: Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, Co. Down BT9 7AB, UK.
authors: Amy J
authors: AJ
authors: McKnight
authors: University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada.
authors: Ruth
authors: R
authors: McPherson
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
authors: Andres
authors: A
authors: Metspalu
authors: School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
authors: Josine L
authors: JL
authors: Min
authors: National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
authors: Miriam F
authors: MF
authors: Moffatt
authors: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
authors: Grant W
authors: GW
authors: Montgomery
authors: National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.|Section of General Internal Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
authors: Joanne M
authors: JM
authors: Murabito
authors: Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.|MRC Harwell, Harwell Science and Innovation Campus, Harwell, UK.
authors: George
authors: G
authors: Nicholson
authors: QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.|Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
authors: Dale R
authors: DR
authors: Nyholt
authors: Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Christian
authors: C
authors: Olsson
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.|Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors: John Rb
authors: JR
authors: Perry
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Eva
authors: E
authors: Reinmaa
authors: Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.|Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors: Rany M
authors: RM
authors: Salem
authors: Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland.|Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.|Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland.
authors: Niina
authors: N
authors: Sandholm
authors: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA.
authors: Eric E
authors: EE
authors: Schadt
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Robert A
authors: RA
authors: Scott
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Lisette
authors: L
authors: Stolk
authors: Computer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico.
authors: Edgar E
authors: EE
authors: Vallejo
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Harm-Jan
authors: HJ
authors: Westra
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK.
authors: Krina T
authors: KT
authors: Zondervan
authors: Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France.
authors: Philippe
authors: P
authors: Amouyel
authors: Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
authors: Dominique
authors: D
authors: Arveiler
authors: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
authors: Stephan Jl
authors: SJ
authors: Bakker
authors: PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.|Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.
authors: John
authors: J
authors: Beilby
authors: Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA.
authors: Richard N
authors: RN
authors: Bergman
authors: Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
authors: John
authors: J
authors: Blangero
authors: Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
authors: Morris J
authors: MJ
authors: Brown
authors: Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland.
authors: Michel
authors: M
authors: Burnier
authors: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.
authors: Harry
authors: H
authors: Campbell
authors: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors: Aravinda
authors: A
authors: Chakravarti
authors: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors: Peter S
authors: PS
authors: Chines
authors: Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Simone
authors: S
authors: Claudi-Boehm
authors: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors: Francis S
authors: FS
authors: Collins
authors: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.|Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
authors: Dana C
authors: DC
authors: Crawford
authors: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors: John
authors: J
authors: Danesh
authors: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
authors: Ulf
authors: U
authors: de Faire
authors: Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.|Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands.
authors: Eco Jc
authors: EJ
authors: de Geus
authors: Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.|DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
authors: Marcus
authors: M
authors: Dörr
authors: Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany.
authors: Raimund
authors: R
authors: Erbel
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.|Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland.
authors: Johan G
authors: JG
authors: Eriksson
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
authors: Martin
authors: M
authors: Farrall
authors: Department of Internal Medicine, University of Pisa, Pisa, Italy.|National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy.
authors: Ele
authors: E
authors: Ferrannini
authors: Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.
authors: Jean
authors: J
authors: Ferrières
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Nita G
authors: NG
authors: Forouhi
authors: UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
authors: Terrence
authors: T
authors: Forrester
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
authors: Ron T
authors: RT
authors: Gansevoort
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
authors: Christian
authors: C
authors: Gieger
authors: Icelandic Heart Association, Kopavogur 201, Iceland.|University of Iceland, Reykjavik 101, Iceland.
authors: Vilmundur
authors: V
authors: Gudnason
authors: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
authors: Christopher A
authors: CA
authors: Haiman
authors: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
authors: Tamara B
authors: TB
authors: Harris
authors: Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
authors: Andrew T
authors: AT
authors: Hattersley
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Markku
authors: M
authors: Heliövaara
authors: Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany.
authors: Andrew A
authors: AA
authors: Hicks
authors: Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
authors: Aroon D
authors: AD
authors: Hingorani
authors: Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.|DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
authors: Wolfgang
authors: W
authors: Hoffmann
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Albert
authors: A
authors: Hofman
authors: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
authors: Georg
authors: G
authors: Homuth
authors: Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK.
authors: Steve E
authors: SE
authors: Humphries
authors: Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.|School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.|South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.|Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
authors: Elina
authors: E
authors: Hyppönen
authors: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany.
authors: Thomas
authors: T
authors: Illig
authors: Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.|Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.|National Institute for Health and Welfare, FI-90101 Oulu, Finland.|MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.|Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.|Institute of Health Sciences, FI-90014 University of Oulu, Finland.
authors: Marjo-Riitta
authors: MR
authors: Jarvelin
authors: Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Berit
authors: B
authors: Johansen
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Pekka
authors: P
authors: Jousilahti
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Antti M
authors: AM
authors: Jula
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.|Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Jaakko
authors: J
authors: Kaprio
authors: UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland.
authors: Frank
authors: F
authors: Kee
authors: Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.|Unit of Primary Health Care/General Practice, Oulu University Hospital, Oulu, Finland.
authors: Sirkka M
authors: SM
authors: Keinanen-Kiukaanniemi
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: Jaspal S
authors: JS
authors: Kooner
authors: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors: Charles
authors: C
authors: Kooperberg
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.|Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany.
authors: Peter
authors: P
authors: Kovacs
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Aldi T
authors: AT
authors: Kraja
authors: Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.|Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK.
authors: Meena
authors: M
authors: Kumari
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Kari
authors: K
authors: Kuulasmaa
authors: Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
authors: Johanna
authors: J
authors: Kuusisto
authors: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
authors: Timo A
authors: TA
authors: Lakka
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.|Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
authors: Claudia
authors: C
authors: Langenberg
authors: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA.
authors: Loic
authors: L
authors: Le Marchand
authors: Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland.
authors: Terho
authors: T
authors: Lehtimäki
authors: Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.|Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden.
authors: Valeriya
authors: V
authors: Lyssenko
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Satu
authors: S
authors: Männistö
authors: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.|Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
authors: André
authors: A
authors: Marette
authors: Department of Genetics, Rutgers University, Piscataway, NJ USA.
authors: Tara C
authors: TC
authors: Matise
authors: UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
authors: Colin A
authors: CA
authors: McKenzie
authors: Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
authors: Barbara
authors: B
authors: McKnight
authors: Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
authors: Arthur W
authors: AW
authors: Musk
authors: Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany.
authors: Stefan
authors: S
authors: Möhlenkamp
authors: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
authors: Andrew D
authors: AD
authors: Morris
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
authors: Mari
authors: M
authors: Nelis
authors: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
authors: Claes
authors: C
authors: Ohlsson
authors: Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors: Albertine J
authors: AJ
authors: Oldehinkel
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.|MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
authors: Ken K
authors: KK
authors: Ong
authors: Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada.|Genetic Epidemiology & Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
authors: Lyle J
authors: LJ
authors: Palmer
authors: Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands.|Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, The Netherlands.
authors: Brenda W
authors: BW
authors: Penninx
authors: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany.
authors: Annette
authors: A
authors: Peters
authors: Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany.|Department of Neurology, General Central Hospital, Bolzano 39100, Italy.
authors: Peter P
authors: PP
authors: Pramstaller
authors: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.|Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland.
authors: Olli T
authors: OT
authors: Raitakari
authors: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors: Tuomo
authors: T
authors: Rankinen
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.|Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.|Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: D C
authors: DC
authors: Rao
authors: Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.|Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Treva K
authors: TK
authors: Rice
authors: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.|Harvard Medical School, Boston, MA 02115, USA.
authors: Paul M
authors: PM
authors: Ridker
authors: Center for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA.
authors: Marylyn D
authors: MD
authors: Ritchie
authors: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.|Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia.
authors: Igor
authors: I
authors: Rudan
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
authors: Veikko
authors: V
authors: Salomaa
authors: Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.|National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK.
authors: Nilesh J
authors: NJ
authors: Samani
authors: South Carelia Central Hospital, 53130 Lappeenranta, Finland.
authors: Jouko
authors: J
authors: Saramies
authors: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors: Mark A
authors: MA
authors: Sarzynski
authors: Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.|Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany.
authors: Peter Eh
authors: PE
authors: Schwarz
authors: Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.|Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.|Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, MD 21201, USA.
authors: Alan R
authors: AR
authors: Shuldiner
authors: Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.|Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, B-3000 Leuven, Belgium.
authors: Jan A
authors: JA
authors: Staessen
authors: deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
authors: Valgerdur
authors: V
authors: Steinthorsdottir
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Ronald P
authors: RP
authors: Stolk
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.
authors: Konstantin
authors: K
authors: Strauch
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.|Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany.
authors: Anke
authors: A
authors: Tönjes
authors: Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada.
authors: Angelo
authors: A
authors: Tremblay
authors: Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy.
authors: Elena
authors: E
authors: Tremoli
authors: Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.|Department of Food Science and Nutrition, Laval University, Quebec, QC G1V 0A6, Canada.
authors: Marie-Claude
authors: MC
authors: Vohl
authors: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.|DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
authors: Uwe
authors: U
authors: Völker
authors: Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland.
authors: Peter
authors: P
authors: Vollenweider
authors: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.
authors: James F
authors: JF
authors: Wilson
authors: Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Jacqueline C
authors: JC
authors: Witteman
authors: Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Linda S
authors: LS
authors: Adair
authors: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.|Ministry of Health, Victoria, Republic of Seychelles.
authors: Murielle
authors: M
authors: Bochud
authors: Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.|Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
authors: Bernhard O
authors: BO
authors: Boehm
authors: Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
authors: Stefan R
authors: SR
authors: Bornstein
authors: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors: Claude
authors: C
authors: Bouchard
authors: CNRS UMR 8199, F-59019 Lille, France.|European Genomic Institute for Diabetes, F-59000 Lille, France.|Université de Lille 2, F-59000 Lille, France.
authors: Stéphane
authors: S
authors: Cauchi
authors: Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
authors: Mark J
authors: MJ
authors: Caulfield
authors: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.|Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.|Imperial College Healthcare NHS Trust, London W12 0HS, UK.
authors: John C
authors: JC
authors: Chambers
authors: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.|Harvard Medical School, Boston, MA 02115, USA.
authors: Daniel I
authors: DI
authors: Chasman
authors: Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA.
authors: Richard S
authors: RS
authors: Cooper
authors: Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
authors: George
authors: G
authors: Dedoussis
authors: Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA.
authors: Luigi
authors: L
authors: Ferrucci
authors: Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.|CNRS UMR 8199, F-59019 Lille, France.|European Genomic Institute for Diabetes, F-59000 Lille, France.|Université de Lille 2, F-59000 Lille, France.
authors: Philippe
authors: P
authors: Froguel
authors: Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.|German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany.
authors: Hans-Jörgen
authors: HJ
authors: Grabe
authors: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
authors: Anders
authors: A
authors: Hamsten
authors: PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.|Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.|School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia.
authors: Jennie
authors: J
authors: Hui
authors: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
authors: Kristian
authors: K
authors: Hveem
authors: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
authors: Karl-Heinz
authors: KH
authors: Jöckel
authors: Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
authors: Mika
authors: M
authors: Kivimaki
authors: MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
authors: Diana
authors: D
authors: Kuh
authors: Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
authors: Markku
authors: M
authors: Laakso
authors: Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors: Yongmei
authors: Y
authors: Liu
authors: Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.|Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.|Synlab Academy, Synlab Services GmbH, Mannheim, Germany.
authors: Winfried
authors: W
authors: März
authors: Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
authors: Patricia B
authors: PB
authors: Munroe
authors: Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
authors: Inger
authors: I
authors: Njølstad
authors: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.|Center for Medical Sytems Biology, Leiden, The Netherlands.|Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors: Ben A
authors: BA
authors: Oostra
authors: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
authors: Colin Na
authors: CN
authors: Palmer
authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
authors: Nancy L
authors: NL
authors: Pedersen
authors: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
authors: Markus
authors: M
authors: Perola
authors: Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.|Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada.
authors: Louis
authors: L
authors: Pérusse
authors: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors: Ulrike
authors: U
authors: Peters
authors: Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
authors: Chris
authors: C
authors: Power
authors: Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
authors: Thomas
authors: T
authors: Quertermous
authors: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
authors: Rainer
authors: R
authors: Rauramaa
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: Fernando
authors: F
authors: Rivadeneira
authors: Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.|Pirkanmaa Hospital District, Tampere, Finland.
authors: Timo E
authors: TE
authors: Saaristo
authors: Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.|Center for Non-Communicable Diseases, Karatchi, Pakistan.|Department of Medicine, University of Pennsylvania, Philadelphia, USA.
authors: Danish
authors: D
authors: Saleheen
authors: Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.
authors: Juha
authors: J
authors: Sinisalo
authors: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.|Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: P Eline
authors: PE
authors: Slagboom
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Harold
authors: H
authors: Snieder
authors: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
authors: Tim D
authors: TD
authors: Spector
authors: deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
authors: Kari
authors: K
authors: Stefansson
authors: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.|Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany.
authors: Michael
authors: M
authors: Stumvoll
authors: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.|Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain.|Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.|Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.
authors: Jaakko
authors: J
authors: Tuomilehto
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: André G
authors: AG
authors: Uitterlinden
authors: Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.|Research Unit, Kuopio University Hospital, Kuopio, Finland.
authors: Matti
authors: M
authors: Uusitupa
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.|Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.|Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
authors: Pim
authors: P
authors: van der Harst
authors: EPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
authors: Giovanni
authors: G
authors: Veronesi
authors: Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK.
authors: Mark
authors: M
authors: Walker
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors: Nicholas J
authors: NJ
authors: Wareham
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
authors: Hugh
authors: H
authors: Watkins
authors: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.|Klinikum Grosshadern, D-81377 Munich, Germany.|Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany.
authors: H-Erich
authors: HE
authors: Wichmann
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Goncalo R
authors: GR
authors: Abecasis
authors: Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
authors: Themistocles L
authors: TL
authors: Assimes
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Sonja I
authors: SI
authors: Berndt
authors: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Michael
authors: M
authors: Boehnke
authors: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Ingrid B
authors: IB
authors: Borecki
authors: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.|William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK.|Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia.
authors: Panos
authors: P
authors: Deloukas
authors: Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors: Lude
authors: L
authors: Franke
authors: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
authors: Timothy M
authors: TM
authors: Frayling
authors: Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.|Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden.
authors: Leif C
authors: LC
authors: Groop
authors: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
authors: David J
authors: DJ
authors: Hunter
authors: Albert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA.
authors: Robert C
authors: RC
authors: Kaplan
authors: Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.|Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors: Jeffrey R
authors: JR
authors: O'Connell
authors: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors: Lu
authors: L
authors: Qi
authors: Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
authors: David
authors: D
authors: Schlessinger
authors: Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK.
authors: David P
authors: DP
authors: Strachan
authors: deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.|Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
authors: Unnur
authors: U
authors: Thorsteinsdottir
authors: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.|Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.|Center for Medical Sytems Biology, Leiden, The Netherlands.
authors: Cornelia M
authors: CM
authors: van Duijn
authors: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
authors: Cristen J
authors: CJ
authors: Willer
authors: Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.|The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia.
authors: Peter M
authors: PM
authors: Visscher
authors: Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.|The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia.
authors: Jian
authors: J
authors: Yang
authors: Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.|Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors: Joel N
authors: JN
authors: Hirschhorn
authors: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.|Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
authors: M Carola
authors: MC
authors: Zillikens
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.|Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK.
authors: Mark I
authors: MI
authors: McCarthy
authors: Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
authors: Elizabeth K
authors: EK
authors: Speliotes
authors: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.|Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors: Kari E
authors: KE
authors: North
authors: National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.
authors: Caroline S
authors: CS
authors: Fox
authors: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.|University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.|NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.
authors: Inês
authors: I
authors: Barroso
authors: Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.|Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors: Paul W
authors: PW
authors: Franks
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.|Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
authors: Erik
authors: E
authors: Ingelsson
authors: Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.|Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
authors: Iris M
authors: IM
authors: Heid
authors: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.|The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Ruth Jf
authors: RJ
authors: Loos
authors: Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.|National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.
authors: L Adrienne
authors: LA
authors: Cupples
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.|Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
authors: Andrew P
authors: AP
authors: Morris
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.
authors: Cecilia M
authors: CM
authors: Lindgren
authors: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Karen L
authors: KL
authors: Mohlke
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D050156:Adipogenesis / Q000235:genetics; D000273:Adipose Tissue / Q000378:metabolism*; D000367:Age Factors; D050218:Body Fat Distribution; D015992:Body Mass Index; D044127:Epigenesis, Genetic; D005060:Europe / Q000208:ethnology; D005260:Female; D015894:Genome, Human / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008954:Models, Biological; D018919:Neovascularization, Physiologic / Q000235:genetics; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics; D012727:Sex Characteristics; D014158:Transcription, Genetic / Q000235:genetics; D049629:Waist-Hip Ratio
chemical_list: D007328:Insulin