title: Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review).
abstract: Colorectal cancer (CRC) is one of the greatest threats to public health. Recent advances in whole-genome transcriptome analyses have enabled the identification of numerous members of a novel class of non-coding (nc)RNA, long ncRNA (lncRNA), which is broadly defined as RNA molecules that are >200 nt in length and lacking an open reading frame. In the present review, all lncRNAs associated with CRC are briefly summarized, with a particular focus on their potential roles as clinical biomarkers. CRC-associated lncRNAs involved in the underlying mechanisms of CRC progression are also initially included. This should benefit the development of novel markers and effective therapeutic targets for patients with CRC.
authors: Department of Oncological Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P.R. China.
authors: LE-Chi
authors: LC
authors: Ye
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
authors: DE-Xiang
authors: X
authors: Zhu
authors: Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China.
authors: Jun-Jun
authors: JJ
authors: Qiu
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
authors: Jianmin
authors: J
authors: Xu
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
authors: Ye
authors: Y
authors: Wei
keywords: colorectal cancer; long non-coding RNA