title: Osteonecrosis related to once-yearly zoledronic acid treatment in an osteoporotic patient after dental implant.
abstract: This paper presents a case of osteonecrosis of the jaw related to zoledronic acid (5 mg) administered once yearly to treat osteoporosis. A 79-year-old woman who has been treated for osteoporosis for 5 years with 5 applications of zoledronic acid was referred for evaluation. The patient had been submitted to dental implant placement and there was no osseointegration. On clinical examination, suppuration and exposed bone on the alveolar ridge were observed. Radiographic examination revealed an osteolytic area and bone sequestration. Both clinical and radiological features were suggestive of osteonecrosis. The treatment consisted of surgery to remove the affected bone completely. The patient is asymptomatic at 9 months after surgery. Dentists and oral surgeons should be alert to the possibility of osteonecrosis related to the use of once-yearly injections of zoledronic acid for the treatment of postmenopausal osteoporosis.
authors: Department of Stomatology, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors: Thais Gimenez
authors: TG
authors: Miniello
authors: Department of Stomatology, School of Dentistry, USP - University of São Paulo, São Paulo, SP, Brazil.
authors: Juliane Pirágine
authors: JP
authors: Araújo
authors: Department of Stomatology, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors: Rodrigo Nascimento
authors: RN
authors: Lopes
authors: Department of Stomatology, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors: Fabio Abreu
authors: FA
authors: Alves
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis* / Q000601:surgery*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D015921:Dental Implants / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid