title: Fluorogenic probe for the human Ether-a-Go-Go-Related Gene potassium channel imaging.
abstract: The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off-on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study.
authors: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.
authors: Zhenzhen
authors: Z
authors: Liu
authors: Beilei
authors: B
authors: Wang
authors: Zhao
authors: Z
authors: Ma
authors: Yubin
authors: Y
authors: Zhou
authors: Lupei
authors: L
authors: Du
authors: Minyong
authors: M
authors: Li
mesh_terms: D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism*; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005454:Fluorescence Polarization; D005456:Fluorescent Dyes / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; D005456:Fluorescent Dyes