title: Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways.
abstract: Lung carcinoma (LC) is one of the most mortal malignant tumors, and is becoming one of most lethal threat to human health and life. LncRNAs, emerging non-coding RNAs but poorly understood, are involved in the proliferation, metastasis, infiltration and apoptosis of LC. In this study, an lncRNA BANCR in LC cells was chosen to investigate the effect on LC cells, and clarify the possible mechanism. The results showed that BANCR levels were downregulated in LC cells. When BANCR expression was improved by tranfection with pcDNA-BANCR vector, tumor growth was suppressed. Vise versa, when BANCR was knockdown by si-BANCR, cell proliferation and migration of LC were remarkably promoted. We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. Moreover, BANCR was found to regulate LC proliferation and migration via not ERK MAPK, but p38 MAPK and JNK inactivations. These findings not only suggested that BANCR may be a new target for LC chemotherapy in future, but also will help us to fully understand the oncogenesis of LC.
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China. Electronic address: wenjunjiang123@163.com.
authors: Wenjun
authors: W
authors: Jiang
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Dandan
authors: D
authors: Zhang
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Baoning
authors: B
authors: Xu
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Zhuo
authors: Z
authors: Wu
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Siyang
authors: S
authors: Liu
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Lei
authors: L
authors: Zhang
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Ye
authors: Y
authors: Tian
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Xu
authors: X
authors: Han
authors: Department of Thoracic Surgery, Fourth Affiliated Hospital of China Medical University, 4, East Chongshan Road, 110032 Shenyang, China.
authors: Dali
authors: D
authors: Tian
mesh_terms: D000818:Animals; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D020935:MAP Kinase Signaling System; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D062085:RNA, Long Noncoding / Q000378:metabolism*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding; D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases
keywords: BANCR; Long non-coding RNA; MAPK; Migration; Proliferation