title: CC motif chemokine ligand 19 suppressed colorectal cancer in vivo accompanied by an increase in IL-12 and IFN-γ.
abstract: In this study we investigate the role of CC motif chemokine ligand 19 (CCL19) to colorectal cancer (CRC) in vivo. We injected different dose of recombinant mouse CCL19 (rmCCL19) in the tumor site of the model of transplanted tumor. Result shows that rmCCL19 can suppress CRC tumorigenesis and growth in vivo, and it can also prolong overall survival of mice. Quantitative reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay results showed that the interferon-γ (IFN-γ) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with rmCCL19.
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Jun
authors: J
authors: Lu
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Junjun
authors: J
authors: Ma
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Wei
authors: W
authors: Cai
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Xiongzhi
authors: X
authors: Wangpu
authors: University of Munich School of Medicine, Munich, Germany.
authors: Hao
authors: H
authors: Feng
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Jingkun
authors: J
authors: Zhao
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China.
authors: Shaopei
authors: S
authors: Guan
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China. Electronic address: zongyp126@126.com.
authors: Yaping
authors: Y
authors: Zong
authors: Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Second Ruijin Road, Shanghai, China. Electronic address: adams_lu66@126.com.
authors: Aiguo
authors: A
authors: Lu
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D054415:Chemokine CCL19 / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism*; D018664:Interleukin-12 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011994:Recombinant Proteins / Q000494:pharmacology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: C515461:Ccl19 protein, mouse; D054415:Chemokine CCL19; D011994:Recombinant Proteins; D018664:Interleukin-12; D007371:Interferon-gamma
keywords: Chemokine CCL19; Colorectal cancer; Immunotherapy