title: Strong and persistent correlation between baseline and follow-up HIV-DNA levels and residual viremia in a population of naïve patients with more than 4 years of effective antiretroviral therapy.
abstract: In a longitudinal study on 181 naïve patients who responded to therapy (mean follow-up 4 years), high baseline human immunodeficiency virus (HIV)-RNA values correlated with high levels of cellular HIV-DNA at all time points (p < 0.0001, p 0.045, p 0.0055, and p 0.0025, respectively) and negatively correlated with undetectable residual viremia (URV; <2.5 copies/mL) at T1, T2, and T3 (p 0.026, p 0.0149, and p 0.0002, respectively). Baseline high HIV-DNA levels predicted the persistence of high values (p 0.0001) and negatively correlated with URV (p 0.0254, p 0.0481, and p 0.0085). These results suggest that baseline viral load, cellular HIV-DNA, and URV were strongly correlated over long-term follow-up of antiretroviral therapy responders.
authors: Department of Molecular Medicine, University of Padova, Padova, Italy. Electronic address: saverio.parisi@unipd.it.
authors: S G
authors: SG
authors: Parisi
authors: Clinical Infectious Diseases, Tor Vergata University, Rome, Italy.
authors: L
authors: L
authors: Sarmati
authors: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors: S
authors: S
authors: Andreis
authors: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors: R
authors: R
authors: Scaggiante
authors: Center of Preventive Medicine & HIV Outpatient Clinic, Verona, Italy.
authors: M
authors: M
authors: Cruciani
authors: Infectious Diseases, Schio Hospital, Schio, Italy.
authors: R
authors: R
authors: Ferretto
authors: Infectious Diseases, Vicenza Hospital, Vicenza, Italy.
authors: V
authors: V
authors: Manfrin
authors: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors: M
authors: M
authors: Basso
authors: Clinical Infectious Diseases, Tor Vergata University, Rome, Italy.
authors: M
authors: M
authors: Andreoni
authors: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors: C
authors: C
authors: Mengoli
authors: Department of Molecular Medicine, University of Padova, Padova, Italy.
authors: G
authors: G
authors: Palù
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load; D014766:Viremia
chemical_list: D004279:DNA, Viral
keywords: Cellular HIV-DNA; HIV-RNA; naïve patients; primary infection; residual viremia