title: Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology.
abstract: Electrochromatography (EC) on a porous monolithic stationary phase prepared within the channels of a microsystem is an attractive alternative for on-chip separation. It combines the separation mechanisms of electrophoresis and liquid chromatography. Moreover, the porous polymer monolithic materials have become popular as stationary phase due to the ease and rapidity of fabrication via free radical photopolymerization. Here, we describe a hexyl acrylate (HA)-based porous monolith which is simultaneously in situ synthesized and anchored to the inner walls of the channel of a cyclic olefin copolymer (COC) device in only 2 min. The baseline separation of a mixture of neurotransmitters including six amino acids and two catecholamines is realized.
authors: Institut des Sciences Analytiques, UMR 5280 (CNRS/Université Lyon 1/ENS Lyon), Université de Lyon, 5 rue de la Doua, 69100, Villeurbanne, France.
authors: Y
authors: Y
authors: Ladner
authors: G
authors: G
authors: Cretier
authors: K
authors: K
authors: Faure
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D053801:Capillary Electrochromatography / Q000379:methods*; D003516:Cycloparaffins / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000179:Acrylates; D003516:Cycloparaffins; D011108:Polymers