title: Prevalence of Hereditary Thrombophilia in Patients Older Than 75 Years With Venous Thromboembolism Referred for Thrombophilia Screening.
abstract: BACKGROUND
  Few studies focused on genetic risk factors for venous thromboembolism (VTE) in the very elderly people. In patients aged 75 years and older with VTE referred for laboratory screening tests for thrombophilia, we aimed: (i) to estimate the F5G1691A and F2G20210A mutation prevalence; (ii) to compare prevalence rates with those of a control group; and (iii) to compare the prevalence rates between patient subgroups, defined as with one or multiple VTE episodes and with provoked/unprovoked VTE.
  
  
  METHODS
  Data were extracted from two prospective thrombophilia registries according to the following inclusion criteria: Caucasian patients aged 75 years and older presenting with at least one confirmed VTE episode. Associated VTE risk factors had been recorded using a standardized questionnaire. Laboratory tests included plasma antithrombin, protein C, and protein S activity measurements and F5G1691A and F2G20210A genotyping.
  
  
  RESULTS
  Of the 312 patients (mean age: 84 ± 6 years; 245 women and 67 men), 47.1% had two or more VTE episodes and 63.5% patients had unprovoked VTE. None had deficiencies in antithrombin, protein C, or protein S. The F5G1691A and F2G20210A mutations were found in 29 (9.3%, 95% confidence interval [CI]: 6.3-13.1) and 18 (5.8%, 95% CI: 3.5-9.0) patients, respectively, versus 3.4% (95% CI: 1.9-4.9) and 3.1% (95% CI: 2.6-3.5) in control subjects (p = .0002 and p = .0082, respectively). Overall, 45 (14.4%) patients carried at least one mutated allele. No associations were found between F5G1691A/F2G20210A, unprovoked VTE or recurrence (p > .05).
  
  
  CONCLUSIONS
  Our study provides new data on genetic risk factors for VTE in the very elderly people. Whether identification of hereditary thrombophilia in elderly patients may influence patient's management in this age group remains unanswered.
authors: UniversitéParis Descartes, Sorbonne Paris Cité, INSERM UMR-S-1140, France. Assistance Publique Hôpitaux de Paris, Service d'Hématologie biologique, Hôpital Européen Georges Pompidou, France. virginie.siguret@parisdescartes.fr.
authors: Virginie
authors: V
authors: Siguret
authors: UniversitéParis Descartes, Sorbonne Paris Cité, INSERM UMR-S-1140, France. Assistance Publique Hôpitaux de Paris, Service de Médecine vasculaire-HTA, Hôpital Européen Georges Pompidou, France.
authors: Joseph
authors: J
authors: Emmerich
authors: UniversitéParis Descartes, Sorbonne Paris Cité, INSERM UMR-S-1140, France.
authors: Tiphaine
authors: T
authors: Belleville
authors: Assistance Publique Hôpitaux de Paris, Département de Biostatistiques, GH Pitié-Salpêtrière-Charles Foix, France.
authors: Jean-Louis
authors: JL
authors: Golmard
authors: Assistance Publique Hôpitaux de Paris, Service d'Hématologie biologique, Hôpital Cochin, France.
authors: Elisabeth
authors: E
authors: Mazoyer
authors: UniversitéParis Descartes, Sorbonne Paris Cité, INSERM UMR-S-1140, France. Assistance Publique Hôpitaux de Paris, Service d'Hématologie biologique, Hôpital Cochin, France.
authors: Isabelle
authors: I
authors: Gouin-Thibault
authors: UniversitéParis Descartes, Sorbonne Paris Cité, INSERM UMR-S-1140, France. Assistance Publique Hôpitaux de Paris, Court séjour gériatrique, DHU FAST, GH Pitié-Salpêtrière-Charles Foix, Ivry sur Seine, France. UniversitéPierre et Marie Curie, Facultéde Médecine, Paris, France.
authors: Eric
authors: E
authors: Pautas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D015995:Prevalence; D019851:Thrombophilia / Q000453:epidemiology*; D054556:Venous Thromboembolism / Q000209:etiology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V
keywords: F2 G20210A mutation; F5 G1691A mutation; Risk factor; Venous thromboembolism