title: Quantum dots encapsulated glycopolymer vesicles: synthesis, lectin recognition and photoluminescent properties.
abstract: Biomimetic star-shaped glycopolymer poly(ɛ-caprolactone)-b-poly(2-aminoethyl methacrylate-b-poly(gluconamidoethylmethacrylate) (SPCL-PAMA-PGAMA) was synthesized by the combination of ring opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. The glycopolymer self-assembled into vesicles with low critical aggregation concentration (CAC) (0.0075 mg/mL). Then, the carboxylic capped CdTe QDs were encapsulated within the glycopolymer vesicles. The QDs encapsulated glycopolymer vesicles (Gly@QDs vesicles) could specifically bind Concanavalin A (Con A) without changing the photoluminescent properties of the Gly@QDs vesicles. Cell viability studies revealed that the cytotoxicity of the Gly@QDs vesicles was remarkably improved as compared to that of the original QDs. The Gly@QDs vesicles were internalized by Hep G2 cells and then emitted green fluorescence in the cells. Consequently, these Gly@QDs vesicles provided a multifunctional platform for targeted delivery and imaging.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors: Danfeng
authors: D
authors: Pei
authors: Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Changchun 130021, Jilin Province, PR China.
authors: Yanchun
authors: Y
authors: Li
authors: Food Science Department, Cook College, Rutgers University, New Brunswick, NJ 08901, United States.
authors: Qingrong
authors: Q
authors: Huang
authors: Clinical Laboratory Center, Air Force General Hospital, No. 30 Fucheng Road, Haidian District, Beijing 100142, PR China.
authors: Qu
authors: Q
authors: Ren
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: fli1216@ciac.ac.cn.
authors: Fan
authors: F
authors: Li
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: tfshi@ciac.ac.cn.
authors: Tongfei
authors: T
authors: Shi
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D016923:Cell Death / Q000187:drug effects; D004705:Endocytosis; D005453:Fluorescence; D056945:Hep G2 Cells; D006801:Humans; D037102:Lectins / Q000032:analysis*; D049449:Luminescence; D010316:Particle Size; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D045663:Quantum Dots / Q000737:chemistry* / Q000633:toxicity; D013057:Spectrum Analysis
chemical_list: D037102:Lectins; D011108:Polymers; D011134:Polysaccharides
keywords: Fluorescent imaging; Glycopolymer vesicles; Lectin recognition; Quantum dots; RAFT polymerization; Targeted delivery