title: Abnormalities of structural covariance networks in drug-naïve boys with attention deficit hyperactivity disorder.
abstract: The aim of this study is to investigate whether the anatomical organization of large-scale brain systems would change in ADHD patients compared to healthy controls. We utilized a structural covariance network (SCN) mapping approach to investigate large-scale networks in 30 drug-naïve ADHD boys and 30 gender- and age-matched controls. The regions showing significant between-group differences in gray matter (GM) volume were defined as seed regions of interest. Then, the SCNs derived from these seeds were statistically compared between ADHD and controls. Significant regional GM volume decreases (P<0.05, corrected) were observed in the right insula and the right orbito-frontal cortex (OFC) in ADHD relative to controls. Both SCNs derived from these two seeds showed more localized topology in ADHD group. Furthermore, significantly decreased structural connectivity were found between insula and right hippocampus, bilateral olfactory cortex, and between OFC and bilateral caudate nucleus (P<0.05, corrected) in ADHD group. Significantly increased association was observed between insula and left middle temporal gyrus (P<0.05, corrected) in ADHD group. Taken together, our results reveal abnormal regional brain anatomy as well as aberrant structural covariance networks in ADHD, supporting previous findings of dysfunction in distributed network organization in patients with ADHD.
authors: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beihang University, Beijing 100191, China; School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China.
authors: Xinwei
authors: X
authors: Li
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Qingjiu
authors: Q
authors: Cao
authors: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beihang University, Beijing 100191, China; School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China.
authors: Fang
authors: F
authors: Pu
authors: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beihang University, Beijing 100191, China; School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China.
authors: Deyu
authors: D
authors: Li
authors: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beihang University, Beijing 100191, China; School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China.
authors: Yubo
authors: Y
authors: Fan
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Li
authors: L
authors: An
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Peng
authors: P
authors: Wang
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Zhaomin
authors: Z
authors: Wu
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
authors: Li
authors: L
authors: Sun
authors: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beihang University, Beijing 100191, China; School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China. Electronic address: shuyuli@buaa.edu.cn.
authors: Shuyu
authors: S
authors: Li
authors: Peking University Sixth Hospital, Beijing 100191, China; Institute of Mental Health, Peking University, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China. Electronic address: wangyf@bjmu.edu.cn.
authors: Yufeng
authors: Y
authors: Wang
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: ADHD; Insula; Orbito-frontal cortex; SCN