title: Adverse Effects of Grape Seed Extract Supplement: A Clinical Case and Long-Term Follow-Up.
abstract: Grape seed extract (GSE) supplement use is becoming more popular today for its potential chemopreventive and chemotherapeutic role. We report a 49-year-old male who presented with recurrent nausea, vomiting, diarrhea, and acute weakness following GSE use. A thorough medical workup ensued and no causes were identified clinically, procedurally, or with imaging. Symptoms resolved after GSE discontinuation and the patient remained symptom-free 5 years later. This case illustrates the paucity of documented detailed clinical cases and lack of controlled trials detailing a thorough and reproducible adverse effect profile of GSE supplement.
authors: a 1 Kansas City University of Medicine and Biosciences , Kansas City, Missouri, USA.
authors: Andrew C
authors: AC
authors: Berry
authors: b 2 Department of Medicine, University of Florida College of Medicine-Jacksonville , Jacksonville, Florida, USA.
authors: Rahman
authors: R
authors: Nakshabendi
authors: c 3 Department of Medicine, Banner Good Samaritan Medical Center , Phoenix, Arizona, USA.
authors: Hussein
authors: H
authors: Abidali
authors: d 4 Department of Neurology, University of Miami Miller School of Medicine , Miami, Florida, USA.
authors: Kunakorn
authors: K
authors: Atchaneeyasakul
authors: e 5 Department of Medicine, Department of Neurology, University of Miami Miller School of Medicine , Miami, Florida, USA.
authors: Kevin
authors: K
authors: Dholaria
authors: f 6 University of South Florida , Tampa, Florida, USA.
authors: Cassandra
authors: C
authors: Johnson
authors: a 1 Kansas City University of Medicine and Biosciences , Kansas City, Missouri, USA.
authors: Varsha A
authors: VA
authors: Kishore
authors: g 7 7GI Associates, Gastroenterology , Milwaukee, Wisconsin, USA.
authors: Aaron C
authors: AC
authors: Baltz
mesh_terms: D003967:Diarrhea / Q000209:etiology / Q000503:physiopathology; D019587:Dietary Supplements / Q000009:adverse effects*; D005500:Follow-Up Studies; D056604:Grape Seed Extract / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology / Q000503:physiopathology; D027843:Vitis / Q000737:chemistry; D014839:Vomiting / Q000209:etiology / Q000503:physiopathology
chemical_list: D056604:Grape Seed Extract
keywords: chemopreventive; grape seed extract; nutrition; supplements