title: Serum IL-17 and IL-6 increased accompany with TGF-β and IL-13 respectively in ulcerative colitis patients.
abstract: OBJECTIVE
  To explorer the serum level of pro- and anti-inflammatory cytokines in the patients of ulcerative colitis and irritable bowel disease. And analyze the correlation between the cytokine's levels and disease's activity of ulcerative colitis patients.
  
  
  METHODS
  Serum cytokines of ulcerative colitis and irritable bowel syndrome with diarrhea patients including IL-6, IL-10, IL-13, IL-17, TNF-α and TGF-β were analyzed by enzyme linked immunosorbent assay, and ulcerative colitis activity were assessed by Mayo scoring system. The correlation of the serum level of cytokines and ulcerative colitis activity were analyzed by the SPSS 19.0 software.
  
  
  RESULTS
  Compared with healthy people, the serum level of IL-6, IL-10, IL-13, IL-17, TNF-α and TGF-β were elevated in ulcerative colitis patients. There is no direct correlation between each cytokines analyzed and the Mayo score. And the level of IL-6 is relevant to IL-13 (r=0.364, P=0.029), and the level of IL-17 is relevant to TGF-β (r=0.336, P=0.045).
  
  
  CONCLUSIONS
  When the pro-inflammatory cytokines increase in the serum of ulcerative colitis, the anti-inflammatory cytokines were increased concomitantly, Some cytokines are positive correlated, such as IL-6 and IL-13, IL-17 and TGF-β, the mechanism of which is complex and needs further investigation.
authors: Department of Traditional Chinese Medicine, The Second Clinical Medical School, Guangdong Key Laboratory for Research, Guangdong Medical College Dongguan 523808, China.
authors: Jin-Shan
authors: JS
authors: Feng
authors: Department of Psychological, Affiliated Hospital of Guangdong Medical College Zhanjiang 524023, China.
authors: Zheng
authors: Z
authors: Yang
authors: Department of Natural Drugs, Guangdong Key Laboratory for Research, Guangdong Medical College Dongguan 523808, China.
authors: Yu-Zhen
authors: YZ
authors: Zhu
authors: Department of Neurology, Affiliated Hospital of Guangdong Medical College Zhanjiang 524023, China.
authors: Zhou
authors: Z
authors: Liu
authors: Department of Natural Drugs, Guangdong Key Laboratory for Research, Guangdong Medical College Dongguan 523808, China.
authors: Can-Can
authors: CC
authors: Guo
authors: Department of Traditional Chinese Medicine, The Second Clinical Medical School, Guangdong Key Laboratory for Research, Guangdong Medical College Dongguan 523808, China.
authors: Xue-Bao
authors: XB
authors: Zheng
keywords: Ulcerative colitis; correlation; cytokine; irritable bowel syndrome; mayo score