title: HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.
abstract: Multiple lines of evidence support an immunologic basis and genetic disposition for the development of age-related macular degeneration (AMD). Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB1) was assessed using next generation sequencing methods and tested for association with age-related macular degeneration (AMD) in a case-control study of 456 AMD cases and 499 controls from the population-based Study of Osteoporotic Fractures (SOF) cohort. No statistically significant associations were identified for any of the class II loci and a previously identified association between DRB1*13:01 was not replicated in this dataset. These results reported here suggest that common HLA class II genetic variation does not contribute to AMD disease risk.
authors: Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
authors: Derek
authors: D
authors: Pappas
authors: Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
authors: Jill
authors: J
authors: Hollenbach
authors: Jules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
authors: Anne L
authors: AL
authors: Coleman
authors: Jules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
authors: Michael B
authors: MB
authors: Gorin
authors: Jules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
authors: Fe
authors: F
authors: Yu
authors: Atreca, Inc., San Carlos, CA 94070, USA.
authors: Kevin
authors: K
authors: Williams
authors: Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
authors: Janelle
authors: J
authors: Noble
authors: California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. Electronic address: gtranah@sfcc-cpmc.net.
authors: Gregory J
authors: GJ
authors: Tranah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059868:HLA-DP beta-Chains / Q000235:genetics; D059848:HLA-DQ alpha-Chains / Q000235:genetics*; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics / Q000276:immunology*; D008297:Male; D011110:Polymorphism, Genetic; D044382:Population Groups
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains
keywords: AMD; Age related macular degeneration; Class II; HLA; Next generation sequencing