title: Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris.
abstract: OBJECTIVE
  Psoriasis is a hyperproliferative chronic inflammatory skin disease of unknown etiology and ocular structures and visual pathways can also be affected during the course of this disease. Subclinical optic neuritis has previously been observed in psoriatic patients in visual evoked potential studies. This trial was designed to evaluate retinal sensitivity in patients with psoriasis vulgaris.
  
  
  METHODS
  A total of 40 eyes of 40 patients with chronic plaque-type psoriasis and 40 eyes of 40 age- and sex-matched control subjects were included in this study. The diagnosis of psoriasis was confirmed by skin biopsy. The severity was determined using the Psoriasis Area and Severity Index and the duration of the disease was recorded. After a full ophthalmological examination, including tests for color vision and pupil reactions, the visual field of each subject was assessed using both standard achromatic perimetry and short wavelength automated perimetry.
  
  
  RESULTS
  The mean Psoriasis Area and Severity Index was 22.05±6.40'. There were no significant differences in the visual field parameters of subjects versus controls using either method. There were correlations between disease severity and the mean deviations in standard achromatic perimetry and short wavelength automated perimetry and between disease severity and the corrected pattern standard deviation and pattern standard deviation of short wavelength automated perimetry (r = -0.363, r = -0.399, r = 0.515 and r = 0.369, respectively).
  
  
  CONCLUSIONS
  Retinal sensitivity appears to be affected by the severity of psoriasis vulgaris.
authors: Department of Ophthalmology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors: Helin Deniz
authors: HD
authors: Demir
authors: Department of Dermatology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
authors: Göknur
authors: G
authors: Kalkan
authors: Department of Neurology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors: Semiha
authors: S
authors: Kurt
authors: Department of Ophthalmology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors: Alper
authors: A
authors: Güneş
authors: Department of Demartology, Faculty of Medicine, Acibadem University, Istanbul, Turkey.
authors: Engin
authors: E
authors: Sezer
authors: Department of Biostatistics, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
authors: Ünal
authors: Ü
authors: Erkorkmaz
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016207:Cytokines / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000473:pathology / Q000503:physiopathology*; D012160:Retina / Q000473:pathology / Q000503:physiopathology*; D012164:Retinal Diseases / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult
chemical_list: D016207:Cytokines