title: Correlation between mean platelet volume and B-type natriuretic peptide concentration in emergency patients with heart failure.
abstract: BACKGROUND
  In heart failure patients, mean platelet volume (MPV) may reflect increased platelet activation or increased numbers of large, hyper-aggregable platelets. B-type natriuretic peptide (BNP) concentration in blood is a sensitive and specific marker of heart failure, correlating with the severity and prognosis of illness, in patients presenting with acute dyspnea to the emergency department. This study evaluated the correlation between BNP concentration and MPV.
  
  
  METHODS
  Data were collected from 319 patients admitted to the emergency department of a cardiology hospital from January-July 2014. EDTA blood samples drawn at admission were analyzed using automated hematology system, and BNP concentration was measured using a fluorescence immunoassay.
  
  
  RESULTS
  The study included 190 patients with and 129 without acute heart failure (AHF). These groups had BNP concentration of 200-5000 ng/L and 5-98 ng/L, respectively. MPV levels were significantly higher in the AHF group (P<0.001). BNP concentrations were positively correlated with MPV (r=0.41, P<0.001) and neutrophil/lymphocyte ratio (r=0.38, P<0.001).
  
  
  CONCLUSIONS
  Increased MPV values correlate with BNP concentration, an indicator of HF severity and clinical status, in patients with AHF admitted to the emergency department.
authors: Department of Clinical Laboratory, Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey.
authors: Yasemin U
authors: YU
authors: Budak
authors: Department of Clinical Laboratory, Sevket Yilmaz Education and Research Hospital Bursa, Turkey.
authors: Kağan
authors: K
authors: Huysal
authors: Department of Family Medicine, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.
authors: Hakan
authors: H
authors: Demirci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D004632:Emergency Medical Services; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D015539:Platelet Activation
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: heart failure; mean platelet volume; natriuretic peptide, brain; platelet