title: Expression of p27 and Jun activation domain-binding protein 1 in endometriosis.
abstract: OBJECTIVE
  The goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls.
  
  
  METHODS
  Ovarian tissues of 26 endometriosis and 28 non-endometriosis patients were used to evaluate expression of p27 and Jab1 by immunohistochemistry.
  
  
  RESULTS
  There are no differences in clinical characteristics between the endometriosis and non-endometriosis group. In the endometriosis group, CD10, Jab1 and p27 were positive in 50, 48.3 and 57.7 % of cases, respectively, compared to 14.3, 17.9 and 50 %, respectively, in the non-endometriosis group. Jab1 and p27 were positive in 69.2 and 84.6 %, respectively, of the definite endometriosis cases.
  
  
  CONCLUSIONS
  These results demonstrate that Jab1 expression was increased in endometriosis, while p27 expression was similar in the endometriosis and non-endometriosis groups.
authors: Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, 420-767, Republic of Korea.
authors: Tae-Hee
authors: TH
authors: Kim
authors: Hae-Hyeog
authors: HH
authors: Lee
authors: Soo-Ho
authors: SH
authors: Chung
authors: Junsik
authors: J
authors: Park
authors: Arum
authors: A
authors: Lee
mesh_terms: D000328:Adult; D000075686:COP9 Signalosome Complex; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D010447:Peptide Hydrolases / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex