title: Anti-inflammatory genes associated with multiple sclerosis: a gene expression study.
abstract: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system caused by a complex interaction between multiple genes and environmental factors. HLA region is the strongest susceptibility locus, but recent huge genome-wide association studies identified new susceptibility genes. Among these, BACH2, PTGER4, RGS1 and ZFP36L1 were highlighted. Here, a gene expression analysis revealed that three of them, namely BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. Interestingly, all these genes are involved in the immune system regulation with predominant anti-inflammatory role and their reduction could predispose to MS development.
authors: Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy. Electronic address: simona.perga@unito.it.
authors: S
authors: S
authors: Perga
authors: Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
authors: F
authors: F
authors: Montarolo
authors: Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
authors: S
authors: S
authors: Martire
authors: Department of Clinical and Biological Sciences, University of Turin, Torino, TO, Italy.
authors: P
authors: P
authors: Berchialla
authors: University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
authors: S
authors: S
authors: Malucchi
authors: Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy; University Hospital San Luigi Gonzaga, Neurobiology Unit, Neurologia 2 - CReSM (Centro Riferimento Regionale Sclerosi Multipla), Orbassano, TO, Italy.
authors: A
authors: A
authors: Bertolotto
mesh_terms: D000328:Adult; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics*; D051817:Butyrate Response Factor 1 / Q000235:genetics*; D015536:Down-Regulation / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D020710:RGS Proteins / Q000235:genetics; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000235:genetics*; D013223:Statistics as Topic
chemical_list: C491123:BACH2 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D051817:Butyrate Response Factor 1; C545650:PTGER4 protein, human; D020710:RGS Proteins; C080831:RGS1 protein, human; D058309:Receptors, Prostaglandin E, EP4 Subtype; C102034:ZFP36L1 protein, human
keywords: GWAS; Gene expression; Inflammation; Multiple sclerosis