title: GYY4137 promotes bone formation in a rabbit distraction osteogenesis model: a preliminary report.
abstract: OBJECTIVE
  Hydrogen sulfide (H2S) has been shown to enhance bone formation, but its osteogenic effect is unclarified during distraction osteogenesis (DO). This study tested the hypothesis that H2S could promote bone formation in a rabbit mandibular DO model.
  
  
  METHODS
  Unilateral mandibular lengthening was achieved in 26 rabbits. During the distraction and the first week of consolidation, saline 0.2 mL or saline 0.2 mL and GYY4137 (H2S donor, 50 mg/kg) was injected intravenously twice a day. Distracted mandibles were examined by dual-energy x-ray absorptiometry, histology, computed tomography, and a 3-point bending test 8 weeks after distraction.
  
  
  RESULTS
  The GYY4137-treated animals presented a greater response as measured by bone mineral density and mechanical properties and a more mature microstructure of the lengthened mandibles compared with the saline-treated control animals.
  
  
  CONCLUSIONS
  The results of this study suggest that H2S can accelerate osteogenesis during DO.
authors: Associate Professor, Department of Stomatology, First People's Hospital of Chenzhou and Institute of Translation Medicine, University of South China, Chenzhou, Hunan, China. Electronic address: jxw0927@163.com.
authors: Xiaowen
authors: X
authors: Jiang
authors: Resident, Department of Stomatology, First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
authors: Yanzhe
authors: Y
authors: Chen
authors: Resident, Department of Stomatology, First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
authors: Kun
authors: K
authors: Lu
authors: Resident, Department of Stomatology, First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
authors: Hao
authors: H
authors: Zhang
authors: Resident, Institute of Translation Medicine, University of South China, Chenzhou, Hunan, China.
authors: Xiaosheng
authors: X
authors: Fan
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects; D016267:External Fixators; D006862:Hydrogen Sulfide / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D018583:Pliability; D011817:Rabbits; D011897:Random Allocation; D012965:Sodium Chloride; D013053:Spectrophotometry / Q000379:methods; D013314:Stress, Mechanical; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: C529376:GYY 4137; D009025:Morpholines; D009946:Organothiophosphorus Compounds; D012965:Sodium Chloride; D006862:Hydrogen Sulfide