title: Viral DNA load of high-risk human papilloma virus is closely associated with the grade of cervical lesions.
abstract: This study is to explore the correlation between the viral load of high-risk human papilloma virus (HPV) and the degree of cervical lesions, as well as the follow-up monitoring role of high-risk HPV measurements in the treatment of patients with cervical lesions. Hybrid capture-2 method was used to measure the amount of high-risk HPV load of 361 patients who were enrolled from January 2009 to December 2010 at the Affiliated Tumor Hospital of Xinjiang Medical University, including 76 cases of cervical squamous carcinoma, 119 cases of cervical intraepithelial neoplasia and 166 cases of cervicitis. The correlation between the viral load of high-risk HPV and the degree of cervical lesions was analyzed using correlation analysis. Patients with cervical intraepithelial neoplasia (CIN) and cervical squamous carcinoma were followed up until December 2013, with the follow-up time being 37-60 months. Statistically significant differences in the high-risk HPV load existed between cervicitis group, CIN group and cervical squamous carcinoma group (P = 0.000). In addition, the viral load was increased with the increase of the severity of cervical lesions, showing a positive correlation (r = 0.436, P = 0.000). During the follow-up, 6 cases of vaginal intraepithelial neoplasia, 3 cases of recurrence CIN and 1 case of vaginal squamous cell carcinoma of the vulva were found, which were shown to relate with the continuing high-risk HPV infection in vagina. Viral load of high-risk HPV were positively correlated with the severity of cervical lesions, playing an important role in the monitoring of patients with cervical lesions after treatment.
authors: The 3rd Department of Gynecological Surgery, The Affiliated Tumor Hospital, Xinjiang Medical University Urumqi City, Xinjiang Autonomous Region, P. R. China.
authors: Guqun
authors: G
authors: Shen
authors: Department of Gynecology and Obstetrics, East Hospital Affiliated to Tongji University Shanghai, P. R. China.
authors: Jingxin
authors: J
authors: Cheng
authors: Department of Scientific Research, The Affiliated Tumor Hospital, Xinjiang Medical University Urumqi City, Xinjiang Autonomous Region, P. R. China.
authors: Yan
authors: Y
authors: Wang
authors: The 3rd Department of Gynecological Surgery, The Affiliated Tumor Hospital, Xinjiang Medical University Urumqi City, Xinjiang Autonomous Region, P. R. China.
authors: Ping
authors: P
authors: Zhou
authors: Hospital Office, The Affiliated Tumor Hospital, Xinjiang Medical University Urumqi City, Xinjiang Autonomous Region, P. R. China.
authors: Guoqing
authors: G
authors: Zhang
keywords: Cervical squamous carcinoma; cervical intraepithelial neoplasia; human papilloma virus; viral load