title: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
abstract: This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Jun
authors: J
authors: Yang
authors: Department of Chemical and Biomolecular Engineering, the University of Akron, USA; Department of Polymer Science, the University of Akron, USA.
authors: Andrea C
authors: AC
authors: Charif
authors: Department of Chemical and Biomolecular Engineering, the University of Akron, USA; Department of Polymer Science, the University of Akron, USA.
authors: Judit E
authors: JE
authors: Puskas
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Hannah
authors: H
authors: Phillips
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Kaitlyn J
authors: KJ
authors: Shanahan
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Jessica
authors: J
authors: Garsed
authors: Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors: Aaron
authors: A
authors: Fleischman
authors: H-Cubed, Inc., Olmsted Falls, OH 44138, USA.
authors: Ken
authors: K
authors: Goldman
authors: Shuvo
authors: S
authors: Roy
authors: Department of Chemical and Biomolecular Engineering, the University of Akron, USA.
authors: Matthew T
authors: MT
authors: Luebbers
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors: Stephen M
authors: SM
authors: Dombrowski
authors: Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: lucianm@ccf.org.
authors: Mark G
authors: MG
authors: Luciano
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects; D007427:Intracranial Pressure; D008297:Male; D008422:Materials Testing; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010969:Plastics / Q000009:adverse effects* / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012408:Rubber / Q000009:adverse effects* / Q000737:chemistry; D012828:Silicones / Q000737:chemistry; D013686:Telemetry / Q000295:instrumentation*; D013696:Temperature; D059015:Wireless Technology / Q000295:instrumentation*
chemical_list: D010969:Plastics; D012828:Silicones; D012408:Rubber
keywords: Biocompatibility; Brain implants; Cerebral cortex; Reactivity; Thermoplastic rubber; Toxicity