title: Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent in patients with acute myocardial infarction.
abstract: BACKGROUND
  There are limited data about long-term outcomes for biodegradable polymer biolimus-eluting stent (BES) versus durable polymer everolimus-eluting stent (EES) in patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We sought to compare the two-year efficacy and safety of BES versus EES in AMI patients.
  
  
  METHODS
  A total of 707 consecutive patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction who underwent PCI with BES (n=171) or EES (n=536) between July 2008 and June 2012 were enrolled in this study. The efficacy endpoint (target vessel failure; a composite of cardiac death, target vessel-related myocardial infarction, and target vessel revascularization) and the safety endpoint (a composite of all cause death, myocardial infarction, and stent thrombosis) at two years were compared in crude and propensity score-matched cohorts.
  
  
  RESULTS
  After two years, target vessel failure occurred in 13 patients treated with BES and 49 patients treated with EES (7.6% versus 9.1%; adjusted hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.58-2.04; p=0.78). The rates of composite safety endpoint at two years were not different between two groups (BES 7.6% versus EES 10.8%; adjusted HR, 0.87; 95% CI, 0.47-1.62; p=0.66). The rates of stent thrombosis did not differ between two groups (BES 0.6% versus EES 1.3%; adjusted HR, 0.63; 95% CI, 0.06-6.20; p=0.69). These findings were substantiated by similar results in the propensity score-matched cohort.
  
  
  CONCLUSIONS
  In the treatment of patients with AMI, BES showed similar efficacy and safety compared to those of EES for up to two years.
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Hyun Jong
authors: HJ
authors: Lee
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Taek Kyu
authors: TK
authors: Park
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: youngbin.song@gmail.com.
authors: Young Bin
authors: YB
authors: Song
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea. Electronic address: cyjheart@gmail.com.
authors: Young Jin
authors: YJ
authors: Choi
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Cheol Woong
authors: CW
authors: Yu
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Jeong Hoon
authors: JH
authors: Yang
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Joo-Yong
authors: JY
authors: Hahn
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Seung-Hyuk
authors: SH
authors: Choi
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Rak Kyeong
authors: RK
authors: Choi
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Jin-Ho
authors: JH
authors: Choi
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Jin Sik
authors: JS
authors: Park
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Je Sang
authors: JS
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Tae Hoon
authors: TH
authors: Kim
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Ho Joon
authors: HJ
authors: Jang
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Sang Hoon
authors: SH
authors: Lee
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Won Heum
authors: WH
authors: Shim
authors: Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
authors: Young Moo
authors: YM
authors: Roh
authors: Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Hyeon-Cheol
authors: HC
authors: Gwon
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D000077144:Clopidogrel; D003328:Coronary Thrombosis / Q000209:etiology / Q000517:prevention & control; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation / Q000379:methods; D011446:Prospective Studies; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin; C518022:umirolimus; D020123:Sirolimus
keywords: Biolimus-eluting stent; Drug-eluting stent; Everolimus-eluting stent; Myocardial infarction; Percutaneous coronary intervention