title: Prokinetics in gastroparesis.
abstract: Prokinetic agents are medications that enhance coordinated gastrointestinal motility and transit of content in the gastrointestinal tract, mainly by amplifying and coordinating the gastrointestinal muscular contractions. In addition to dietary therapy, prokinetic therapy should be considered as a means to improve gastric emptying and symptoms of gastroparesis, balancing benefits and risks of treatment. In the United States, metoclopramide remains the first-line prokinetic therapy, because it is the only approved medication for gastroparesis. Newer agents are being developed for the management of gastroparesis. This article provides detailed information about prokinetic agents for the treatment of gastroparesis.
authors: Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
authors: Andres
authors: A
authors: Acosta
authors: Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: camilleri.michael@mayo.edu.
authors: Michael
authors: M
authors: Camilleri
mesh_terms: D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005769:Gastrointestinal Motility; D018589:Gastroparesis / Q000188:drug therapy*; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use; D056687:Off-Label Use; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D008787:Metoclopramide
keywords: Domperidone; Erythromycin; Ghrelin; Metoclopramide; Pharmacology; Pyridostigmine; Receptor; Relamorelin; Serotonin