title: Shift in serotype distribution of Shigella species in China, 2003-2013.
abstract: We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003-2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-:7,8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-:7,8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003-2004 to 84.1% during 2011-2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate.
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: S
authors: S
authors: Qiu
authors: Shanghai Municipal Centre for Disease Control & Prevention, Shanghai, China.
authors: X
authors: X
authors: Xu
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: C
authors: C
authors: Yang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: J
authors: J
authors: Wang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, China.
authors: B
authors: B
authors: Liang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: P
authors: P
authors: Li
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: H
authors: H
authors: Li
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: S
authors: S
authors: Yi
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: H
authors: H
authors: Liu
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: X
authors: X
authors: Cui
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Z
authors: Z
authors: Wu
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: J
authors: J
authors: Xie
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: L
authors: L
authors: Jia
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: L
authors: L
authors: Wang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: R
authors: R
authors: Hao
authors: Shanghai Municipal Centre for Disease Control & Prevention, Shanghai, China.
authors: H
authors: H
authors: Jin
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Y
authors: Y
authors: Wang
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors: Y
authors: Y
authors: Sun
authors: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China. Electronic address: hongbinsong@263.net.
authors: H
authors: H
authors: Song
mesh_terms: D002681:China / Q000453:epidemiology; D004405:Dysentery, Bacillary / Q000453:epidemiology* / Q000266:history / Q000382:microbiology*; D049674:History, 21st Century; D006801:Humans; D015995:Prevalence; D065288:Serogroup; D012760:Shigella / Q000145:classification* / Q000302:isolation & purification
keywords: Atypical serotype; Shigella; serotype distribution; shift; vaccine development