title: Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives.
abstract: Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts, chondroblasts, adipocytes, and even myoblasts. Most studies have focused on finding MSCs in different parts of the body for medical treatment. Every joint structure, including bone, joint fat, articular cartilage, and synovium, potentially contains resident MSCs. Recently, a progenitor cell population has been found in synovial fluid and showed similarities with both bone marrow and synovial membrane MSCs. Synovial fluid MSCs have been studied in healthy persons and osteoarthritic patients in order to explore its potential for treatment of some orthopedic disorders. Here, we briefly review the current knowledge on synovial fluid MSCs, their origin, relation to some orthopedic diseases, and future applications.
authors: Eduardo Branco
authors: EB
authors: de Sousa
authors: Priscila Ladeira
authors: PL
authors: Casado
authors: Vivaldo
authors: V
authors: Moura Neto
authors: Maria Eugenia Leite
authors: ME
authors: Duarte
authors: Diego Pinheiro
authors: DP
authors: Aguiar
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D013582:Synovial Fluid / Q000166:cytology*; D013583:Synovial Membrane / Q000166:cytology*