title: Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control.
abstract: Polymeric nanoparticle has been developed for drug delivery during the past decades. However, the size of hydrophilic nanoparticles would increase in the aqueous environment due to water absorption, and then influence the in vivo biodistribution and drug release behavior. In the present study, the metronidazole-loaded porous Eudragit® RS (ERS)/poly(methyl methacrylate) (PMMA) core/shell nanoparticles were prepared by coaxial electrospray. Compared to the hydrophilic ERS nanoparticles, the porous hydrophilic core/hydrophobic shell nanoparticles displayed a slower drug release, and the release rate can be adjusted to change the surface area and particle size. In addition, the porous core/shell nanoparticles could maintain a stable particle size distribution in simulated body fluid for 8h, which can be attributed to the bioinert nature of PMMA coating. And porous core/shell nanoparticles showed slight in vitro cytotoxicity and good cellular internalization property. The results demonstrated that the prepared porous hydrophilic core/hydrophobic shell nanoparticles is a potential candidate for delivering drugs, which can also be used as a platform and further modified into targeted drug delivery systems for clinical application.
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Shilei
authors: S
authors: Hao
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China. Electronic address: wangbc2000@126.com.
authors: Bochu
authors: B
authors: Wang
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors: Yazhou
authors: Y
authors: Wang
mesh_terms: D002152:Calorimetry, Differential Scanning; D008854:Microscopy, Electron; D053758:Nanoparticles; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000737:chemistry; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D019904:Polymethyl Methacrylate
keywords: Core/shell nanoparticles; Drug delivery systems; Drug release; Particle size distribution; Porous hydrophilic coating