title: Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers.
abstract: Proteins and peptides are increasingly important therapeutics for the treatment of severe and complex diseases like cancer or autoimmune diseases due to their high specificity and potency. Their unique structure and labile physicochemical properties, however, require special attention in the production and formulation process as well as during administration. Aside from conventional systemic injections, the topical application of proteins and peptides is an appealing alternative due to its non-invasive nature and thus high acceptance by patients. For this approach, soft matter nanocarriers are interesting delivery systems which offer beneficial properties such as high biocompatibility, easiness of modifications, as well as targeted drug delivery and release. This review aims to highlight and discuss technological developments in the field of soft matter nanocarriers for the delivery of proteins and peptides via the skin, the eye, the nose, and the lung, and to provide insights in advantages, limitations, and practicability of recent advances.
authors: Department of Pharmaceutical Sciences, Ludwig-Maximilians-Universität, Munich, Germany.
authors: Madeleine
authors: M
authors: Witting
authors: Institute for Pharmaceutical Sciences, Freie Universität Berlin, Germany.
authors: Katja
authors: K
authors: Obst
authors: Department of Pharmaceutical Sciences, Ludwig-Maximilians-Universität, Munich, Germany.
authors: Wolfgang
authors: W
authors: Friess
authors: Institute for Pharmaceutical Sciences, Freie Universität Berlin, Germany. Electronic address: sarah.hedtrich@fu-berlin.de.
authors: Sarah
authors: S
authors: Hedtrich
mesh_terms: D000287:Administration, Topical; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008168:Lung / Q000187:drug effects; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry; D012879:Skin Physiological Phenomena
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D011506:Proteins; D048271:Chitosan
keywords: Biopharmaceuticals; Dermal; Nasal; Ocular; Peptides; Proteins; Pulmonary; Soft matter nanocarrier; Targeted drug delivery; Topical delivery