title: A brief history of T cell help to B cells.
abstract: In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+) T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.
authors: Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, California 92037, USA.
authors: Shane
authors: S
authors: Crotty
mesh_terms: D000486:Allergy and Immunology / Q000266:history*; D001402:B-Lymphocytes / Q000276:immunology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*