title: [Clinical features, risk factors and susceptibility profile of mycobacterial infections documented by culture in a university hospital of high complexity in Medellin (Colombia)].
abstract: BACKGROUND
  Tuberculosis (TB) remains an entity of high prevalence and mortality worldwide. The rising drug resistance is a public health problem. Besides, non-tuberculosis mycobacterial (NTM) infections are described with increasing frequency in areas of high prevalence of TB.
  
  
  OBJECTIVE
  To determine epidemiological, clinical and microbiological characteristics of mycobacterial infections documented by culture.
  
  
  METHODS
  An observational, descriptive study in hospitalized patients.
  
  
  RESULTS
  M. tuberculosis complex was identified in 90,9% of 187 patients; 9,1% had NTM, 64% were male and the mean age was 40 years (range 1-88 years). The main co-morbidities were HIV / AIDS (23.5%), use of corticosteroids (13.3%) and chronic kidney disease (9.6%). Clinical forms were pulmonary (56.6%), extra-pulmonary (23.9%) and disseminated (19.2 The most common extra-pulmonary compromise was nodal (7.4%) and gastrointestinal (7%). 10.6% of M. tuberculosis were multi-drug resistant (MDR) and 2.12% had extended drug resistance (XDR). Mycobacterium avium andM. abscessus were the most frequent NTM. Overall mortality was 10%.
  
  
  CONCLUSIONS
  In our study immune suppression is the main risk factor for extrapulmonary and disseminated disease. Resistance, MDR and XDR is higher in inpatients with TB. MNT infections are not uncommon in our country.
authors: Franco E
authors: FE
authors: Montufar Andrade
authors: Carolina
authors: C
authors: Aguilar Londoño
authors: Carolina
authors: C
authors: Saldarriaga Acevedo
authors: Alicia
authors: A
authors: Quiroga Echeverri
authors: Carlos E
authors: CE
authors: Builes Montaño
authors: Miguel A
authors: MA
authors: Mesa Navas
authors: Olga L
authors: OL
authors: Molina Upegüi
authors: John J
authors: JJ
authors: Zuleta Tobón
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D009164:Mycobacterium Infections / Q000276:immunology / Q000382:microbiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents