title: Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients.
abstract: The issue about bone marrow hematopoietic progenitor cells harbouring HIV-DNA in infected patients is still under scrutiny. We studied nine HIV-infected individuals undergoing bone marrow aspiration for diagnostic purposes. In all patients, even in those receiving successful antiretroviral therapy for several years, HIV-DNA was detected in purified CD34+ lineage-bone marrow progenitor cells. This finding, although not conclusive due to the low number of patients examined, adds further evidence that current treatment strategies may be insufficient to resolve latent infection in bone marrow CD34+ hematopoietic progenitor cells.
authors: Cellular Immunology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy. Electronic address: veronica.bordoni@inmi.it.
authors: V
authors: V
authors: Bordoni
authors: Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: M
authors: M
authors: Bibas
authors: Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: I
authors: I
authors: Abbate
authors: Cellular Immunology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: D
authors: D
authors: Viola
authors: Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: G
authors: G
authors: Rozera
authors: Cellular Immunology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy; Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: C
authors: C
authors: Agrati
authors: Cellular Immunology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: A
authors: A
authors: Rinaldi
authors: Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: A
authors: A
authors: Amendola
authors: Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: A
authors: A
authors: Ammassari
authors: Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: M R
authors: MR
authors: Capobianchi
authors: Cellular Immunology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
authors: F
authors: F
authors: Martini
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D023241:Antiretroviral Therapy, Highly Active; D001854:Bone Marrow Cells / Q000378:metabolism / Q000821:virology*; D004279:DNA, Viral; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000821:virology*; D006801:Humans; D016130:Immunophenotyping; D011533:Proviruses / Q000235:genetics; D019562:Viral Load
chemical_list: D018952:Antigens, CD34; D004279:DNA, Viral
keywords: Bone marrow; HIV infection; hematopoietic progenitor cells; proviral DNA; viral load