title: Predictive factors of functional capacity and real-world functioning in patients with schizophrenia.
abstract: OBJECTIVE
  This study was performed to identify the predictive factors of functional capacity assessed by the Spanish University of California Performance Skills Assessment (Sp-UPSA) and real-world functioning assessed by the Spanish Personal and Social Performance scale (PSP) in outpatients with schizophrenia.
  
  
  METHODS
  Naturalistic, 6-month follow-up, multicentre, validation study. Here, we report data on 139 patients with schizophrenia at their baseline visit.
  
  
  RESULTS
  Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S), Sp-UPSA and PSP.
  
  
  METHODS
  Pearson's correlation coefficient (r) was used to determine the relationships between variables, and multivariable stepwise linear regression analyses to identify predictive variables of Sp-UPSA and PSP total scores.
  
  
  RESULTS
  Functional capacity: scores on the PSP and PANSS-GP entered first and second at P<0.0001 and accounted for 21% of variance (R(2)=0.208, model df=2, F=15.724, P<0.0001). Real-world functioning: scores on the CGI-S (B=-5.406), PANSS-N (B=-0.657) and Sp-UPSA (B=0.230) entered first, second and third, and accounted for 51% of variance (model df=3, F=37.741, P<0.0001).
  
  
  CONCLUSIONS
  In patients with schizophrenia, functional capacity and real-world functioning are two related but different constructs. Each one predicts the other along with other factors; general psychopathology for functional capacity, and severity of the illness and negative symptoms for real-world functioning. These findings have important clinical implications: (1) both types of functioning should be assessed in patients with schizophrenia and (2) strategies for improving them should be different.
authors: Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain.
authors: I
authors: I
authors: Menendez-Miranda
authors: Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
authors: M P
authors: MP
authors: Garcia-Portilla
authors: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain. Electronic address: lettti@gmail.com.
authors: L
authors: L
authors: Garcia-Alvarez
authors: Servicio de Psiquiatría, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.
authors: M
authors: M
authors: Arrojo
authors: Unidad de Psicosis Refractarias, Hospital Psiquiátrico de Alava, Vitoria, Spain.
authors: P
authors: P
authors: Sanchez
authors: ESM Montoro, Hospital Reina Sofía de Córdoba, Spain.
authors: F
authors: F
authors: Sarramea
authors: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain; Litwin Zucker Alzheimer's Disease Center, Feinstein Institute for Medical Research/AECOM, Manhassett, NY; FIDMAG, Hermanas Hospitalarias Sant Boi de Llobregat, Spain.
authors: J
authors: J
authors: Gomar
authors: Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
authors: M T
authors: MT
authors: Bobes-Bascaran
authors: Servicio de Psiquiatria, Hospital Universitario La Fe, Avda, Fernando Abril Martorell 106, 46026 Valencia, Spain.
authors: P
authors: P
authors: Sierra
authors: Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
authors: P A
authors: PA
authors: Saiz
authors: Area de Psiquiatria, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain.
authors: J
authors: J
authors: Bobes
mesh_terms: D000203:Activities of Daily Living; D000223:Adaptation, Psychological; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D012044:Regression Analysis; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D013647:Task Performance and Analysis
keywords: Functional capacity; Predictive factors; Real-world functioning; Schizophrenia