title: Selective solid-phase extraction of artificial chemicals from milk samples using multiple-template surface molecularly imprinted polymers.
abstract: A novel multiple-template surface molecularly imprinted polymer (MTMIP) was synthesized using ofloxacin and 17β-estradiol as templates and modified monodispersed poly(glycidylmethacrylate-co-ethylene dimethacrylate) (PGMA/EDMA ) beads as the support material. Static adsorption, solid-phase extraction and high-performance liquid chromatography were performed to investigate the adsorption properties and selective recognition characteristics of the polymer templates and their structural analogs. The maximum binding capacities of ofloxacin and 17β-estradiol on the MTMIP were 9.0 and 6.6 mg/g, respectively. Compared with the corresponding nonimprinted polymer, the MTMIP exhibited a much higher adsorption performance and selectivity toward three quinolones and three estrogens, which are common drug residues in food. The MTMIP served as a simple and effective pretreatment method and could be successfully applied to the simultaneous analysis of multiple target components in complex samples. Furthermore, the MTMIP may find useful applications as a solid-phase absorbent in the simultaneous determination of trace quinolones and estrogens in milk samples, as the recoveries were in the range 77.6-98.0%.
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors: Jing
authors: J
authors: Zhang
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors: Yan-li
authors: YL
authors: Ni
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors: Ling-ling
authors: LL
authors: Wang
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors: Jin-qin
authors: JQ
authors: Ma
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors: Zhi-qi
authors: ZQ
authors: Zhang
mesh_terms: D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004958:Estradiol / Q000302:isolation & purification; D004967:Estrogens / Q000302:isolation & purification*; D005506:Food Contamination / Q000032:analysis; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D015242:Ofloxacin / Q000302:isolation & purification; D015363:Quinolones / Q000302:isolation & purification*; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D004967:Estrogens; D015363:Quinolones; D004958:Estradiol; D015242:Ofloxacin
keywords: estrogen; multiple-template surface molecularly imprinted polymer; quinolone; simultaneous analysis; solid-phase extraction