title: Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis.
abstract: Some previous articles reported that antiviral treatment was effective to reduce the colectomy rate in ulcerative colitis (UC) patients with cytomegalovirus (CMV) infection. Kopylov et al recently carried out a systematic review and meta-analysis to evaluate the impact of antiviral therapy on CMV-positive UC. The results showed that patients who received antiviral treatment had a higher risk of 30-d colectomy. We found that in this meta-analysis, some studies were inappropriately included, leading to an unfavorable outcome of anti-CMV therapy in UC patients.
authors: Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Xiao-Wei
authors: XW
authors: Wu
authors: Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Miao-Fang
authors: MF
authors: Yang
authors: Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Nan
authors: N
authors: Li
authors: Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
authors: Fang-Yu
authors: FY
authors: Wang
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery*; D003106:Colon / Q000187:drug effects* / Q000601:surgery*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D000998:Antiviral Agents
keywords: Antiviral therapy; Colectomy; Cytomegalovirus; Meta-analysis; Ulcerative colitis