title: [Treatment of tubal ectopic pregnancy by methotrexate].
abstract: OBJECTIVE
  To make a literature analyse about methotrexate as a treatment of tubal ectopic pregnancy.
  
  
  METHODS
  We made a PubMed research and found articles, randomized control studies, systematic revues and meta-analyses of the Cochrane Database about ectopic pregnancies treated by methotrexate. We made a summary of these articles.
  
  
  RESULTS
  Methotrexate can be used as a treatment of tubal ectopic pregnancy with hCG<5000 UI/L and expectative is an option if hCG level is lower than 1500 UI/L. Medical treatment by methotrexate seems to be less effective than surgical salpingotomy but the rate of recurrence and the rate of intra-uterine pregnancy are similar regardless of the treatment chosen. Fertility seems to be the same after treatment by methotrexate. Economically, methotrexate is less expensive than the surgical management (laparoscopy).
  
  
  CONCLUSIONS
  Methotrexate can be used as a treatment of tubal ectopic pregnancies if every criterions of safety are gathered.
authors: Service de gynécologie-obstétrique, CHU Bicêtre, 78, avenue du général-Leclerc, 94276 Le Kremlin-Bicêtre, France. Electronic address: magali.lesavre@bct.aphp.fr.
authors: M
authors: M
authors: Lesavre
authors: Service de gynécologie-obstétrique, CHU Estaing, 1, place Lucie-Aubrac, 63003 Clermont Ferrand, France.
authors: S
authors: S
authors: Curinier
authors: Service de gynécologie-obstétrique, CHU Bicêtre, 78, avenue du général-Leclerc, 94276 Le Kremlin-Bicêtre, France.
authors: P
authors: P
authors: Capmas
authors: Service de gynécologie-obstétrique, CHU Estaing, 1, place Lucie-Aubrac, 63003 Clermont Ferrand, France.
authors: B
authors: B
authors: Rabischong
authors: Service de gynécologie-obstétrique, CHU Bicêtre, 78, avenue du général-Leclerc, 94276 Le Kremlin-Bicêtre, France.
authors: H
authors: H
authors: Fernandez
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate
keywords: Coût économique; Economic cost; Ectopic pregnancy; Fertility; Fertilité; Grossesse extra-utérine; Methotrexate; Méthotrexate