title: Caveolin-1, galectin-3 and lipid raft domains in cancer cell signalling.
abstract: Spatial organization of the plasma membrane is an essential feature of the cellular response to external stimuli. Receptor organization at the cell surface mediates transmission of extracellular stimuli to intracellular signalling molecules and effectors that impact various cellular processes including cell differentiation, metabolism, growth, migration and apoptosis. Membrane domains include morphologically distinct plasma membrane invaginations such as clathrin-coated pits and caveolae, but also less well-defined domains such as lipid rafts and the galectin lattice. In the present chapter, we will discuss interaction between caveolae, lipid rafts and the galectin lattice in the control of cancer cell signalling.
authors: *Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
authors: Jay
authors: J
authors: Shankar
authors: *Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
authors: Cecile
authors: C
authors: Boscher
authors: *Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
authors: Ivan R
authors: IR
authors: Nabi
mesh_terms: D001798:Blood Proteins; D051242:Caveolin 1 / Q000235:genetics / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism / Q000648:ultrastructure; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism / Q000648:ultrastructure; D037502:Galectin 3 / Q000235:genetics / Q000378:metabolism*; D037161:Galectins; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism* / Q000648:ultrastructure; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
chemical_list: D001798:Blood Proteins; D051242:Caveolin 1; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D002784:Cholesterol; C000601122:Mgat5 protein, human; D017351:N-Acetylglucosaminyltransferases; C512478:EGFR protein, human; D066246:ErbB Receptors