title: Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia.
abstract: Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress, mitochondrial dysfunction and inflammation may have a role in the pathophysiology of fibromyalgia. Despite several skin-related symptoms accompanied by small fiber neuropathy have been studied in FM, these mitochondrial changes have not been yet studied in this tissue. Skin biopsies from patients showed a significant mitochondrial dysfunction with reduced mitochondrial chain activities and bioenergetics levels and increased levels of oxidative stress. These data were related to increased levels of inflammation and correlated with pain, the principal symptom of FM. All these parameters have shown a role in peripheral nerve damage which has been observed in FM as a possible responsible to allodynia. Our findings may support the role of oxidative stress, mitochondrial dysfunction and inflammation as interdependent events in the pathophysiology of FM with a special role in the peripheral alterations.
authors: Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain.
authors: Benito
authors: B
authors: Sánchez-Domínguez
authors: Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain.
authors: Pedro
authors: P
authors: Bullón
authors: Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain.
authors: Lourdes
authors: L
authors: Román-Malo
authors: Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain.
authors: Fabiola
authors: F
authors: Marín-Aguilar
authors: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Sevilla, Spain.
authors: Elísabet
authors: E
authors: Alcocer-Gómez
authors: División de Neurociencias, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013 Sevilla, Spain.
authors: Angel M
authors: AM
authors: Carrión
authors: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Sevilla, Spain; Universidad Autónoma de Chile, Chile.
authors: José Antonio
authors: JA
authors: Sánchez-Alcazar
authors: Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain. Electronic address: mdcormor@us.es.
authors: Mario D
authors: MD
authors: Cordero
mesh_terms: D000328:Adult; D001706:Biopsy; D004734:Energy Metabolism; D005260:Female; D005356:Fibromyalgia / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008875:Middle Aged; D008928:Mitochondria / Q000502:physiology*; D018384:Oxidative Stress; D010146:Pain / Q000503:physiopathology; D010525:Peripheral Nerves / Q000473:pathology; D012867:Skin / Q000473:pathology*
keywords: Fibromyalgia; Inflammation; Mitochondrial dysfunction; Oxidative stress