title: A narrow-bandgap benzobisthiadiazole derivative with high near-infrared photothermal conversion efficiency and robust photostability for cancer therapy.
abstract: Photothermal therapy has emerged as a promising tool for treatment of diseases such as cancers. Previous photothermal agents have been largely limited to inorganic nanomaterials and conductive polymers that are barely biodegradable, thus raising issues of long-term toxicity for clinical applications. Here we report a new photothermal agent based on colloidal nanoparticles formed by a small-molecular dye, benzo[1,2-c;4,5-c']bis[1,2,5]thiadiazole-4,7-bis(5-(2-ethylhexyl)thiophene). These nanoparticles showed strong near-infrared absorption, robust photostability and high therapeutic efficiency for photothermal treatment of cancer cells.
authors: School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459. quanliu@ntu.edu.sg mfwang@ntu.edu.sg.
authors: Shuo
authors: S
authors: Huang
authors: Ravi Kumar
authors: RK
authors: Kannadorai
authors: Yuan
authors: Y
authors: Chen
authors: Quan
authors: Q
authors: Liu
authors: Mingfeng
authors: M
authors: Wang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D006046:Gold / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D006801:Humans; D006979:Hyperthermia, Induced; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy; D013830:Thiadiazoles / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects
chemical_list: D004396:Coloring Agents; D013830:Thiadiazoles; D006046:Gold