title: Inhibition of antiplatelet effects of aspirin by nonopioid analgesics.
abstract: In patients undergoing coronary bypass grafting, we noticed that low-dose aspirin failed to inhibit platelet aggregation, potentially elevating the risk of thrombotic bypass occlusion. This "high on-treatment platelet reactivity" was reproducible in vitro and could be transferred with patient plasma or urine to aspirin-sensitive donor platelets, suggesting a drug/drug interaction. Loss of aspirin efficacy was associated with analgesia by dipyrone (metamizol) and initiated further study of the interaction between aspirin and other nonopioid analgesics.
authors: Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
authors: T
authors: T
authors: Hohlfeld
authors: K
authors: K
authors: Schrör
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D001241:Aspirin