title: Age differences in periventricular and deep white matter lesions.
abstract: Deep white matter hyperintensity (DWMH) and periventricular (PV) white matter lesion volumes are associated with age and subsequent stroke. We studied age differences in these volumes accounting for collinearity and risk factors. Subjects were 563 healthy family members of early-onset coronary artery disease patients. Using 3T magnetic resonance imaging, lesions were classified as DWMH or PV. Age association with lesion classification was analyzed using random effects Tobit regression, adjusting for intracranial volume (ICV) and risk factors. Subjects were 60% women, 36% African-American, mean age 51 ± 11 years. In multivariable analysis adjusted for PV and ICV, DWMH was associated with age (p < 0.001) and female sex (p = 0.003). PV, adjusted for DWMH and ICV, was age associated (p < 0.001). For each age decade, DWMH showed 0.07 log units/decade greater volume (95% CI = 0.04-0.11); PV was 0.18 log units/decade greater (95% CI = 0.14-0.23); slope differences (p < 0.001). In people with a family history of coronary artery disease, PV and DWMH are independently and differentially associated with age controlling for traditional risk factors.
authors: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: pnyquis1@jhmi.edu.
authors: Paul A
authors: PA
authors: Nyquist
authors: Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Murat
authors: M
authors: Bilgel
authors: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Rebecca
authors: R
authors: Gottesman
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Lisa R
authors: LR
authors: Yanek
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Taryn F
authors: TF
authors: Moy
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Lewis C
authors: LC
authors: Becker
authors: Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA; Divisions of Diagnostic Radiology and Neuroradiology, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Jennifer L
authors: JL
authors: Cuzzocreo
authors: Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA; Divisions of Diagnostic Radiology and Neuroradiology, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Jerry
authors: J
authors: Prince
authors: Divisions of Diagnostic Radiology and Neuroradiology, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Bruce A
authors: BA
authors: Wasserman
authors: Divisions of Diagnostic Radiology and Neuroradiology, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: David M
authors: DM
authors: Yousem
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Diane M
authors: DM
authors: Becker
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA; Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Brian G
authors: BG
authors: Kral
authors: Division of General Internal Medicine, Department of Medicine, GeneSTAR Research Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors: Dhananjay
authors: D
authors: Vaidya
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012737:Sex Factors; D066127:White Matter / Q000473:pathology*
keywords: Coronary; Imaging; Risk factors; White matter disease; Women and minorities