title: A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes.
abstract: The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)2 associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1 mol % Pd can be achieved.
authors: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon (Hong Kong).
authors: On Ying
authors: OY
authors: Yuen
authors: Mueangkaew
authors: M
authors: Charoensak
authors: Chau Ming
authors: CM
authors: So
authors: Chutima
authors: C
authors: Kuhakarn
authors: Fuk Yee
authors: FY
authors: Kwong
mesh_terms: D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D010165:Palladium
keywords: CH arylation; aryl chlorides; palladium; phosphine; polyfluoroarenes