title: Long-Term Therapy with Lenalidomide in a Patient with POEMS Syndrome.
abstract: Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Benjamin F
authors: BF
authors: Chu
authors: Department of Pathology, Ohio State University, Columbus, OH, United States.
authors: Arwa
authors: A
authors: Shana'ah
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Craig C
authors: CC
authors: Hofmeister
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Don M
authors: DM
authors: Benson
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Megan
authors: M
authors: Sell
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Jill
authors: J
authors: Tucker
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Flavia
authors: F
authors: Pichiorri
authors: Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, OH, United States.
authors: Yvonne A
authors: YA
authors: Efebera
keywords: Lenalidomide; POEMS