title: Clonal distribution of multidrug-resistant Enterobacter cloacae.
abstract: A multilocus sequence typing (MLST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various β-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme.
authors: INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France.
authors: Delphine
authors: D
authors: Girlich
authors: INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
authors: Laurent
authors: L
authors: Poirel
authors: INSERM U914 "Emerging Resistance to Antibiotics", K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland; Hopital Fribourgeois-hôpital Cantonal, Fribourg, Switzerland. Electronic address: patrice.nordmann@unifr.ch.
authors: Patrice
authors: P
authors: Nordmann
mesh_terms: D016000:Cluster Analysis; D024901:Drug Resistance, Multiple, Bacterial; D016972:Enterobacter cloacae / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005798:Genes, Bacterial; D020043:Genes, Essential; D014644:Genetic Variation; D005838:Genotype; D014943:Global Health; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D058885:Multilocus Sequence Typing; D017422:Sequence Analysis, DNA
keywords: Enterobacter cloacae; MLST; Multidrug-resistant bacteria; Prevalence