title: Does HIV infection have an impact upon dental implant osseointegration? A systematic review.
abstract: OBJECTIVE
  A systematic review is made to determine whether human immunodeficiency virus (HIV) infection has an impact upon dental implant osseointegration.
  
  
  METHODS
  A PubMed (MEDLINE) literature search was made of articles published up until 14 April 2014. The systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The quality of the studies included in the review was assessed using the Methodological Index for Nonrandomized Studies (MINORS) and levels of evidence (based on the University of Oxford's Center for Evidence Based Medicine criteria).
  
  
  RESULTS
  The combinations of search terms resulted in a list of 132 titles. Nine studies finally met the inclusion criteria and were selected for inclusion in the systematic review. A total of 173 dental implants were placed in 80 patients (135 implants in 56 HIV-positive subjects and 38 implants in 24 HIV-negative patients), and a single loss of dental implant osseointegration was recorded in an HIV-positive patient.
  
  
  CONCLUSIONS
  Our results suggest that dental implant placement in HIV-positive patients does not increase the dental implant failure rate. Prophylactic antibiotic treatment, the administration of highly active antiretroviral therapy, and control of the CD4+ T lymphocyte counts appear to be the main influencing factors in this respect. Given the few studies included in our systematic review, further prospective studies involving larger sample sizes and longer durations of follow-up are required in order to confirm the results obtained.
authors: Public Dental Health Service, Arnau de Vilanova Hospital, San Clemente Street 12, 46015-Valencia, Spain, javiataali@hotmail.com.
authors: Javier
authors: J
authors: Ata-Ali
authors: Fadi
authors: F
authors: Ata-Ali
authors: Nicolas
authors: N
authors: Di-Benedetto
authors: Leticia
authors: L
authors: Bagán
authors: José-Vicente
authors: JV
authors: Bagán
mesh_terms: D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D015658:HIV Infections; D006801:Humans; D012307:Risk Factors
chemical_list: D015921:Dental Implants