title: The pathological role and prognostic impact of miR-181 in acute myeloid leukemia.
abstract: In addition to genetic abnormalities, such as chromosomal translocations and somatic mutations that have been widely acknowledged in the leukemogenesis of acute myeloid leukemia (AML), epigenetic modifications also play a vital role in this process. MicroRNA (miRNA) regulation is emerging as a new layer of epigenetic regulation besides DNA methylation and histone modifications. Among the miRNAs first identified to be specifically expressed in hematopoietic cells, the miR-181 family has been implicated in regulating the differentiation of B cells, T cells, and natural killer cells during normal hematopoiesis, and has been linked tightly to the pathogenesis and prognosis of AML. Accumulating evidence indicates that miR-181 acts as a tumor suppressor in the pathogenesis of AML and exhibits a significant impact on the survival of patients with AML. Herein, we review the role of miR-181 as a diagnostic marker and prognostic predictor in AML, and discuss the potential use of miR-181 as a therapeutic target for AML.
authors: Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
authors: Hengyou
authors: H
authors: Weng
authors: Biological Sciences Collegiate Division, University of Chicago, Chicago, IL, USA; Rush Medical College, Rush University Medical Center, Chicago, IL, USA.
authors: Kumar
authors: K
authors: Lal
authors: Biological Sciences Collegiate Division, University of Chicago, Chicago, IL, USA; School of Medicine, Stanford University, Stanford, CA, USA.
authors: Frank F
authors: FF
authors: Yang
authors: Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: jchen@bsd.uchicago.edu.
authors: Jianjun
authors: J
authors: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000502:physiology*; D044127:Epigenesis, Genetic; D016147:Genes, Tumor Suppressor; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality*; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C540193:MIrn181 microRNA, human; D035683:MicroRNAs
keywords: Acute myeloid leukemia; diagnostic marker; miR-181; prognostic predictor; tumor suppressor