title: Mammary carcinoma with osteoclast-like giant cells: a case report.
abstract: Mammary carcinoma with osteoclast-like giant cells is rare, and comprises less that 2% of breast carcinoma cases. Herein, we present a case of a 45-year-old woman who underwent breast lumpectomy and sentinel lymph node biopsy for a solitary well defined breast tumor. Histological examination revealed an invasive tumor composed of ducts, small nests and cribriform formations intermixed with a prominent osteoclast like giant cell component. The background stroma is hemorrhagic with conspicuous hemosiderin deposition. The paper will outline the clinico-pathologic characteristic features of this uncommon subtype as well as the current understanding on the pathogenesis of the osteoclast-like giant cells. The invasive carcinoma and the osteoclast-like giant cells staining patterns using immunohistochemical stains for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, receptor activator of nuclear-kB, RANK ligand, and matrix metalloproteinase 1 are reported.
authors: Department of Pathology, College of Medicine & Health Sciences Al Ain, United Arab Emirates ; Tawam Hospital Al Ain, United Arab Emirates.
authors: Alia Saeed
authors: AS
authors: Albawardi
authors: Tawam Hospital Al Ain, United Arab Emirates.
authors: Aktham Adnan
authors: AA
authors: Awwad
authors: Department of Pathology, College of Medicine & Health Sciences Al Ain, United Arab Emirates ; Tawam Hospital Al Ain, United Arab Emirates.
authors: Saeeda Saleh
authors: SS
authors: Almarzooqi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018286:Carcinoma, Giant Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D059186:Chemoradiotherapy, Adjuvant; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010010:Osteoclasts / Q000737:chemistry / Q000473:pathology*; D021701:Sentinel Lymph Node Biopsy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Mammary carcinoma; RANK ligand (RANKL) expression; estrogen receptor (ER); human epidermal growth factor receptor 2 (Her2/neu); matrix metalloproteinase 1 (MMP1); osteoclast like giant cells; progesterone receptor (PR); receptor activator of nuclear-kB expression (RANK)