title: [Neurofascin: a novel target for combined central and peripheral demyelination].
abstract: Combined central and peripheral demyelination (CCPD) is a rare clinical entity characterized by inflammatory demyelination in both the central and peripheral nervous system. A recently conducted nation-wide survey revealed that clinical features of CCPD are atypical for multiple sclerosis, including an absence of oligoclonal immunoglobulin G bands in most CCPD cases. We found that autoantibody responses of CCPD target the nodes and paranodes of Ranvier in the brain and peripheral nerve tissues. We identified anti-neurofascin antibody in the serum from these CCPD patients. CCPD patients showed a significantly higher positive rate of anti-neurofascin antibody than the other limited form of inflammatory demyelinating diseases. Autoantibody responses targeting neurofascins, which are common proteins to the central and peripheral nervous system may play a pivotal role in combined demyelination in CCPD.
authors: Department of Neurology, Kawamura Hospital.
authors: Nobutoshi
authors: N
authors: Kawamura
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D002493:Central Nervous System Diseases / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D003711:Demyelinating Diseases / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology / Q000628:therapy; D009414:Nerve Growth Factors / Q000276:immunology*; D043025:Oligoclonal Bands; D010523:Peripheral Nervous System Diseases / Q000235:genetics* / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D015815:Cell Adhesion Molecules; C054305:NFASC protein, human; D009414:Nerve Growth Factors; D043025:Oligoclonal Bands