title: Acute cutaneous graft-versus-host disease resembling type II (atypical adult) pityriasis rubra pilaris.
abstract: We present a case of cutaneous acute graft-versus-host disease (aGVHD) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris (PRP), which developed 26 days after allogeneic peripheral blood stem cell transplant. Skin histology confirmed features of both aGVHD and PRP. The skin lesions were refractory to oral prednisolone and cyclosporine and only partially responsive to a combination of i.v. methylprednisolone, oral tacrolimus, oral mycophenolate mofetil, and infusions of anti-thymocyte globulin and the tumour necrosis factor-α inhibitor, etanercept.
authors: Queensland Institute of Dermatology, Greenslopes Private Hospital, Brisbane, Queensland, Australia.
authors: Devita
authors: D
authors: Surjana
authors: Ivan
authors: I
authors: Robertson
authors: Glen
authors: G
authors: Kennedy
authors: Daniel
authors: D
authors: James
authors: David
authors: D
authors: Weedon
mesh_terms: D000328:Adult; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D010916:Pityriasis Rubra Pilaris / Q000473:pathology*; D014184:Transplantation, Homologous / Q000009:adverse effects
keywords: graft-versus-host disease; hematopoietic stem cell transplantation; pityriasis rubra pilaris