title: Prognostic importance of ultrasound BI-RADS classification in breast cancer patients.
abstract: OBJECTIVE
  We investigated the prognostic importance of pre-operative Breast Imaging Reporting and Data System classification in ultrasound imaging.
  
  
  METHODS
  Histopathological differences and disease-free survival were analyzed in Breast Imaging Reporting and Data System classification subgroups. Univariate and multivariate analyses were used to identify the prognostic factors.
  
  
  RESULTS
  We identified 531 invasive breast cancer patients eligible for this study. Most patients classified as Breast Imaging Reporting and Data System 5 had large tumors and a higher rate of lymph node metastasis. However, hormonal receptor or HER-2 status did not differ according to Breast Imaging Reporting and Data System classification. During a median post-operative follow-up of 42.0 months, 43 patients were diagnosed with a disease-specific event. Disease-free survival was significantly lower in patients with Breast Imaging Reporting and Data System 5 than in patients with Breast Imaging Reporting and Data System 3-4. Subgroup analysis of patients with invasive breast cancer of Stage I showed that Breast Imaging Reporting and Data System 5 was an independent negative prognostic indicator of disease-free survival (hazard ratio 9.195; 95% confidence interval, 1.175-71.955; P = 0.035).
  
  
  CONCLUSIONS
  Breast Imaging Reporting and Data System classification might be considered as prognostic factors especially in Stage I breast cancer. Further confirmatory studies are needed.
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Ju-Yeon
authors: JY
authors: Kim
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea drjej@gnu.ac.kr.
authors: Eun Jung
authors: EJ
authors: Jung
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Taejin
authors: T
authors: Park
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Sang-Ho
authors: SH
authors: Jeong
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Chi-Young
authors: CY
authors: Jeong
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Young-Tae
authors: YT
authors: Ju
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Young-Joon
authors: YJ
authors: Lee
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Soon-Chan
authors: SC
authors: Hong
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Woo-Song
authors: WS
authors: Ha
authors: Department of Surgery, School of Medicine, Gyeongsang National University, Jin-ju, South Korea.
authors: Sang-Kyung
authors: SK
authors: Choi
mesh_terms: D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D016217:Ultrasonography, Mammary
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: BI-RADS; breast cancer; ultrasound