title: IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?
abstract: IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.
authors: IGFs & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK.
authors: Li
authors: L
authors: Zeng
authors: IGFs & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK. Electronic address: claire.m.perks@bristol.ac.uk.
authors: Claire M
authors: CM
authors: Perks
authors: IGFs & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol BS10 1TD, UK.
authors: Jeff M P
authors: JM
authors: Holly
mesh_terms: D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction
chemical_list: D018971:Insulin-Like Growth Factor Binding Protein 2; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: Feedback; IGF-II; IGFBP-2; PI3K; PTEN