title: Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.
abstract: BACKGROUND
  Repetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies assessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce.
  
  
  OBJECTIVE
  To assess the benefit of rTMS in a rat model of PTSD.
  
  
  METHODS
  Using a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parameters were acquired using open field test (OFT), elevated plus maze test (EPMT), and prepulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats.
  
  
  RESULTS
  Anxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immediately after stress prevented those impairment.
  
  
  CONCLUSIONS
  Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Hua-Ning
authors: HN
authors: Wang
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Yuan-Han
authors: YH
authors: Bai
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Yun-Chun
authors: YC
authors: Chen
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Rui-Guo
authors: RG
authors: Zhang
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Huai-Hai
authors: HH
authors: Wang
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Ya-Hong
authors: YH
authors: Zhang
authors: Department of Psychiatry, 91 Hospital of P. L. A., Jiaozuo, 454150, China.
authors: Jing-Li
authors: JL
authors: Gan
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Zheng-Wu
authors: ZW
authors: Peng
authors: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors: Qing-Rong
authors: QR
authors: Tan
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology / Q000628:therapy; D001522:Behavior, Animal; D004195:Disease Models, Animal; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D055139:Sensory Gating; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000628:therapy