title: Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice.
abstract: In this study, the antidiabetic effects of a hot water extract of edible Chrysanthemum morifolium Ramat. (HW-ECM) were investigated in type 2 diabetic mice. HW-ECM improved blood glucose levels and insulin resistance and increased adiponectin mRNA expression in adipose tissues and protein concentrations in the plasma. Moreover, it increased adipose mRNA and protein expressions of peroxisome proliferator-activated receptor γ (PPARγ), a regulator of adiponectin transcription, and mRNA expression of its downstream target genes. It also reduced the adipose cell size and attenuated the mRNA expression of pro-inflammatory adipocytokines in adipose tissues. These data presumably indicate a hypoglycemic mechanism of HW-ECM, involving increased PPARγ expression, decreased the adipocyte sizes, and suppression of chronic inflammation in adipose tissues. Finally, elevated adiponectin levels lead to amelioration of insulin resistance and the corresponding hypoglycemic effects. Therefore, HW-ECM indicates its potential as a functional food for type 2 diabetes.
authors: a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors: Junpei
authors: J
authors: Yamamoto
authors: Miki
authors: M
authors: Tadaishi
authors: Takumi
authors: T
authors: Yamane
authors: Yuichi
authors: Y
authors: Oishi
authors: Makoto
authors: M
authors: Shimizu
authors: Kazuo
authors: K
authors: Kobayashi-Hattori
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D052242:Adiponectin / Q000097:blood / Q000235:genetics; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D031202:Chrysanthemum / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D008820:Mice, Obese; D009929:Organ Size / Q000187:drug effects; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D015434:Panniculitis / Q000235:genetics; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D052242:Adiponectin; C499919:Adipoq protein, mouse; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D010936:Plant Extracts
keywords: Chrysanthemum morifolium Ramat; PPARγ; adiponectin; inflammation; type 2 diabetes