title: Cooperative binding of ferrocenylnaphthalene diimide carrying β-cyclodextrin converts double-stranded DNA to a rod-like structure.
abstract: Ferrocenylnaphthalene diimide carrying β-cyclodextrin (β-CD), 1, intercalated into double-stranded DNA with a binding affinity of K = (6.6 ± 0.8) × 10(4) M(-1) and a binding site size of n = 4, with a high positive cooperative parameter of ω = 14. β-CD and ferrocene moieties of the compound contributed to the formation of the intermolecular inclusion complex on DNA. Binding of 1 resulted in conversion of the DNA duplex to a rod-like form, which was cleaved upon adamantylamine addition.
authors: †Department of Applied Chemistry, ‡Research Center for Biomicrosensing Technology, and §Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan.
authors: Shinobu
authors: S
authors: Sato
authors: †Department of Applied Chemistry, ‡Research Center for Biomicrosensing Technology, and §Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan.
authors: Yuta
authors: Y
authors: Umeda
authors: †Department of Applied Chemistry, ‡Research Center for Biomicrosensing Technology, and §Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan.
authors: Satoshi
authors: S
authors: Fujii
authors: †Department of Applied Chemistry, ‡Research Center for Biomicrosensing Technology, and §Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan.
authors: Shigeori
authors: S
authors: Takenaka
mesh_terms: D001665:Binding Sites / Q000502:physiology; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D005296:Ferrous Compounds / Q000737:chemistry* / Q000378:metabolism*; D007094:Imides / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D005296:Ferrous Compounds; D007094:Imides; D047392:beta-Cyclodextrins; C406363:ferrocenylnaphthalene diimide; D004247:DNA; C031215:betadex