title: Hyperbaric oxygen treatment and enteral nutrition support with glutamine relieves traumatic brain injury in the rats.
abstract: The abnormal metabolic processes following traumatic brain injury (TBI) have been proposed to contribute to secondary injuries after TBI. Therefore, enteral nutrition (EN) support for TBI patients has received more attention. This study aimed to evaluate the complimentary effects of enteral nutrition with glutamine and hyperbaric oxygen (HBO) on the recovery of TBI. TBI model was established in SD rats, which were randomly divided into four groups: TBI, TBI + HBO, TBI + GLN, and TBI + HBO + GLN. Neuronal apoptosis in penumbra area was detected by TUNEL. Serum prealbumin level was detected by ELISA. Motor function was evaluated by beam-balance test. We found that the body weight of the rats had no significant differences in different groups before and after injury. Among the four groups, beam-balance test score was the lowest, serum prealbumin level was the highest, and neuronal apoptosis rate was the lowest in TBI + HBO + GLN group on day 3 and 7 after TBI. In conclusion, our data suggest that hyperbaric oxygen combined with enteral nutrition support with glutamine is effective in reducing neuronal apoptosis, increasing serum prealbumin concentration and improving neurological function after TBI injury.
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China ; Department of Neurosurgery, The First People's Hospital of Suqian 260 Taihu Road, Suqian 223800, Jiangsu, China.
authors: Xianhua
authors: X
authors: Fu
authors: Department of Neurosurgery, Siyang People's Hospital 26 Zhongxing Road, Siyang 223700, Jiangsu, China.
authors: Min
authors: M
authors: Zhu
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Xiaoyang
authors: X
authors: Sun
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Dazhao
authors: D
authors: Fang
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Weijie
authors: W
authors: Wang
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Nan
authors: N
authors: Dong
authors: Department of Neurosurgery, The First People's Hospital of Suqian 260 Taihu Road, Suqian 223800, Jiangsu, China.
authors: Cong
authors: C
authors: Pang
authors: Department of Neurosurgery, Siyang People's Hospital 26 Zhongxing Road, Siyang 223700, Jiangsu, China.
authors: Xiaoning
authors: X
authors: Liu
authors: Department of Central Laboratory, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Fengli
authors: F
authors: Chen
authors: Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China ; Department of Central Laboratory, Huai'an First People's Hospital, Nanjing Medical University 6 Beijing Road West, Huai'an 223300, Jiangsu, China.
authors: Lianshu
authors: L
authors: Ding
keywords: Hyperbaric oxygen; glutamine; traumatic brain injury