title: Obesity, lymphadenectomy and survival outcomes in intermediate to high-risk, early-stage endometrial cancer patients.
abstract: OBJECTIVE
  Lymphadenectomy or lymph node dissection is a topic of controversy in endometrial cancer (EC) treatment.
  
  
  METHODS
  Associations between lymph node dissections and clinical factors were retrospectively examined in obese, endometrioid endometrial cancer patients with early-stage disease between 1995 and 2005. Overall, EC-specific and recurrence-free survival were also evaluated.
  
  
  RESULTS
  Out of 192 patients, 61 (32%) did not have a lymph node examination, 55 (29%) had less than ten lymph nodes removed and 76 (39%) had ≥10 removed. Lymph node dissection count was not significantly associated with overall, EC-specific or recurrence-free survival.
  
  
  CONCLUSIONS
  Analysis revealed no significant associations between ≥10 dissected lymph nodes and survival outcomes among obese, EC patients, which supports the need for additional investigation of the merit of lymphadenectomy among these patients.
authors: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 4200 Fifth Avenue, Pittsburgh, PA 15260, USA.
authors: Faina
authors: F
authors: Linkov
authors: Robert P
authors: RP
authors: Edwards
authors: Andrew
authors: A
authors: Althouse
authors: Jose A
authors: JA
authors: Rauh-Hain
authors: Marcela G
authors: MG
authors: Del Carmen
authors: Kyle E
authors: KE
authors: Freese
authors: Joseph L
authors: JL
authors: Kelley
authors: Alexander B
authors: AB
authors: Olawaiye
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: endometrial cancer; gynecology; lymphadenectomy; obesity; oncology; survival