title: Prospects for genetically modified non-human primate models, including the common marmoset.
abstract: Genetically modified mice have contributed much to studies in the life sciences. In some research fields, however, mouse models are insufficient for analyzing the molecular mechanisms of pathology or as disease models. Often, genetically modified non-human primate (NHP) models are desired, as they are more similar to human physiology, morphology, and anatomy. Recent progress in studies of the reproductive biology in NHPs has enabled the introduction of exogenous genes into NHP genomes or the alteration of endogenous NHP genes. This review summarizes recent progress in the production of genetically modified NHPs, including the common marmoset, and future perspectives for realizing genetically modified NHP models for use in life sciences research.
authors: Advanced Research Center, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan; Center of Applied Developmental Biology, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki, Kanagawa 210-0821, Japan. Electronic address: esasaki@ciea.or.jp.
authors: Erika
authors: E
authors: Sasaki
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D002144:Callithrix / Q000235:genetics*; D055786:Gene Knockout Techniques; D023421:Models, Animal; D019076:Transgenes
keywords: Common marmoset; Genome editing; Target gene KO; Transgenic