title: Blood-brain barrier: an impediment to neuropharmaceuticals.
abstract: The blood-brain barrier (BBB) serves as a highly selective barrier separating the central nervous system from the systemic circulation. Although contributing to neurological health, the BBB restricts the ability of drugs to reach their site of action and thus presents a major challenge to the treatment of neurological disorders. Advances in our understanding of the complexity of the BBB have fostered development of novel pharmacometric models and drug delivery strategies to better predict and improve therapeutic access.
authors: Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada.
authors: J T
authors: JT
authors: Henderson
authors: M
authors: M
authors: Piquette-Miller
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002491:Central Nervous System Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D002491:Central Nervous System Agents; D004364:Pharmaceutical Preparations