title: Microbiota modulation of myeloid cells in cancer therapy.
abstract: Myeloid cells represent a major component of the tumor microenvironment, where they play divergent dual roles. They can induce antitumor immune responses, but mostly they promote immune evasion, tumor progression, and metastasis formation. Thus, strategies aiming at reprogramming the tumor microenvironment represent a promising immunotherapy approach. Myeloid cells respond to environmental factors including signals derived from commensal microbes. In this Cancer Immunology at the Crossroads overview, we discuss recent advances on the effects of the commensal microbiota on myeloid-cell functions and how they affect the response to cancer therapy.
authors: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. trinchig@mail.nih.gov rgoldszmid@mail.nih.gov.
authors: Romina S
authors: RS
authors: Goldszmid
authors: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. Leidos Biomedical Research, Inc., Bethesda, Maryland.
authors: Amiran
authors: A
authors: Dzutsev
authors: Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, Villejuif, France. Université Paris-Sud, Kremlin Bicêtre, France.
authors: Sophie
authors: S
authors: Viaud
authors: Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, Villejuif, France. Université Paris-Sud, Kremlin Bicêtre, France.
authors: Laurence
authors: L
authors: Zitvogel
authors: Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
authors: Nicholas P
authors: NP
authors: Restifo
authors: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. trinchig@mail.nih.gov rgoldszmid@mail.nih.gov.
authors: Giorgio
authors: G
authors: Trinchieri
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D064307:Microbiota / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D013559:Symbiosis / Q000276:immunology; D059016:Tumor Microenvironment / Q000276:immunology