title: Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions.
abstract: BACKGROUND
  Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model.
  
  
  METHODS
  Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies.
  
  
  CONCLUSIONS
  Rats pretreated either with famotidine or CoQ10 had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ10 pretreatment for 7 days group (p < 0.00625).
authors: K
authors: K
authors: Karakaya
authors: F
authors: F
authors: Barut
authors: V
authors: V
authors: Hanci
authors: M
authors: M
authors: Can
authors: M
authors: M
authors: Comert
authors: H B
authors: HB
authors: Ucan
authors: G K
authors: GK
authors: Cakmak
authors: O
authors: O
authors: Irkorucu
authors: O
authors: O
authors: Tascilar
authors: A U
authors: AU
authors: Emre
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D014815:Vitamins; D014451:Ubiquinone; D000431:Ethanol; C024989:coenzyme Q10