title: The expression of Fcγ receptors in Hashimoto's thyroiditis.
abstract: The pathophysiological mechanism underlying Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are diagnostic hallmarks of HT. These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fcγ receptors (FcγRs). The aim of our study was to investigate the role of FcγRs in the pathogenesis of HT. The percentage of peripheral blood mononuclear cells (PBMCs) from HT patients bearing FcγRII was significantly lower than that seen in healthy donors, and the mean fluorescence intensity (MFI) value of FcγRII on PBMCs from HT patients was significantly higher. The percentage of PBMCs positive for FcγRIII also was significantly higher in HT patients, and the percentage of B cells bearing FcγRIIB in HT patients was significantly lower than that seen in healthy donors. Our study therefore provides evidence for FcγRs, especially FcγRIIB, being involved in the pathogenesis of HT.
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: liuyalei88@163.com.
authors: Yalei
authors: Y
authors: Liu
authors: Institute of Microcirculation, Chinese Academy of Medical Science, Beijing 100005, PR China. Electronic address: g0046898@vip.sina.com.
authors: Mingming
authors: M
authors: Liu
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: emilyzy14@gmail.com.
authors: Yang
authors: Y
authors: Zhang
authors: Department of Clinical Laboratory, Peking University First Hospital, Beijing 100034, PR China. Electronic address: qucx2012@163.com.
authors: Chenxue
authors: C
authors: Qu
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: luguizhi64@sina.com.
authors: Guizhi
authors: G
authors: Lu
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: huangyouyuan1905@163.com.
authors: Youyuan
authors: Y
authors: Huang
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: yamuzhang0229@163.com.
authors: Hong
authors: H
authors: Zhang
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: yunan_7936@sina.com.
authors: Nan
authors: N
authors: Yu
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: yuanshanshan_2006@126.com.
authors: Shanshan
authors: S
authors: Yuan
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: bjgaoying@yahoo.com.
authors: Ying
authors: Y
authors: Gao
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: bdyygaoyanming@hotmail.com.
authors: Yanming
authors: Y
authors: Gao
authors: Department of Endocrinology, Peking University First Hospital, Beijing 100034, PR China. Electronic address: guoxh@medmail.com.cn.
authors: Xiaohui
authors: X
authors: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D050031:Hashimoto Disease / Q000276:immunology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D001324:Autoantigens; C080571:Fc gamma receptor IIB; D033862:Iron-Binding Proteins; D017452:Receptors, IgG; D013954:Thyroglobulin; C056658:TPO protein, human; D007453:Iodide Peroxidase
keywords: B cells; FcγRIIB; FcγRs; Hashimoto’s thyroiditis