title: Coprisamides A and B, new branched cyclic peptides from a gut bacterium of the dung beetle Copris tripartitus.
abstract: Coprisamides A and B (1 and 2) were isolated from a bacterium in the gut of the dung beetle Copris tripartitus. Spectroscopic analysis revealed that the planar structures of 1 and 2 are novel cyclic heptapeptides bearing unusual units, such as β-methylaspartic acid and 2,3-diaminopropanoic acid branched to valine and 2-heptatrienyl cinnamic acid. Absolute configurations were established by chemical derivatization and chiroptical spectroscopy. The coprisamides displayed significant activity for induction of quinone reductase.
authors: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul, 151-742, Republic of Korea.
authors: Soohyun
authors: S
authors: Um
authors: So Hyun
authors: SH
authors: Park
authors: Jihye
authors: J
authors: Kim
authors: Hyen Joo
authors: HJ
authors: Park
authors: Keebeom
authors: K
authors: Ko
authors: Hea-Son
authors: HS
authors: Bang
authors: Sang Kook
authors: SK
authors: Lee
authors: Jongheon
authors: J
authors: Shin
authors: Dong-Chan
authors: DC
authors: Oh
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001517:Coleoptera / Q000382:microbiology*; D005243:Feces; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces / Q000737:chemistry*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D010456:Peptides, Cyclic; C000601272:coprisamide A; C000601273:coprisamide B; D015091:beta-Alanine; C011757:2,3-diaminopropionic acid