title: Intermediate filaments in cell migration and invasion: the unusual suspects.
abstract: Cell migration is a multistep process which relies on the coordination of cytoskeletal structures in space and time. While the roles of actin and microtubules have been investigated in great details, the lack of inhibitors and visualizing tools and the large number of proteins forming intermediate filaments (IFs) have delayed the characterization of IF functions during migration. However, a large body of evidence has progressively pointed to changes in IF composition as an important parameter in the regulation of cell migratory properties both during development and tumor invasion. More recent in-depth analyses show that IFs are dynamically reorganized to participate, together with microfilaments and microtubules, to the key steps leading to cell migration.
authors: Institut Pasteur - CNRS UMR 3691, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.
authors: Cécile
authors: C
authors: Leduc
authors: Institut Pasteur - CNRS UMR 3691, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address: sandrine.etienne-manneville@pasteur.fr.
authors: Sandrine
authors: S
authors: Etienne-Manneville
mesh_terms: D008841:Actin Cytoskeleton; D000199:Actins / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D003599:Cytoskeleton / Q000737:chemistry; D006801:Humans; D007381:Intermediate Filament Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007382:Intermediate Filaments / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D009361:Neoplasm Invasiveness
chemical_list: D000199:Actins; D007381:Intermediate Filament Proteins