title: Functional and anatomical properties of human visual cortical fields.
abstract: Human visual cortical fields (VCFs) vary in size and anatomical location across individual subjects. Here, we used functional magnetic resonance imaging (fMRI) with retinotopic stimulation to identify VCFs on the cortical surface. We found that aligning and averaging VCF activations across the two hemispheres provided clear delineation of multiple retinotopic fields in visual cortex. The results show that VCFs have consistent locations and extents in different subjects that provide stable and accurate landmarks for functional and anatomical mapping. Interhemispheric comparisons revealed minor differences in polar angle and eccentricity tuning in comparable VCFs in the left and right hemisphere, and somewhat greater intersubject variability in the right than left hemisphere. We then used the functional boundaries to characterize the anatomical properties of VCFs, including fractional anisotropy (FA), magnetization transfer ratio (MTR) and the ratio of T1W and T2W images and found significant anatomical differences between VCFs and between hemispheres.
authors: Beijing Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, PR China; Human Cognitive Neurophysiology Lab, VA Research Service, VA-NCHCS, 150 Muir Road, Martinez, CA 94553, USA; Department of Neurology and Center for Neuroscience, 4860 Y St., Suite 3700, Sacramento, CA 95817, USA.
authors: Shouyu
authors: S
authors: Zhang
authors: Psychology Department, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors: Anthony D
authors: AD
authors: Cate
authors: Human Cognitive Neurophysiology Lab, VA Research Service, VA-NCHCS, 150 Muir Road, Martinez, CA 94553, USA.
authors: Timothy J
authors: TJ
authors: Herron
authors: Human Cognitive Neurophysiology Lab, VA Research Service, VA-NCHCS, 150 Muir Road, Martinez, CA 94553, USA; Department of Neurology and Center for Neuroscience, 4860 Y St., Suite 3700, Sacramento, CA 95817, USA. Electronic address: xkang@ucdavis.edu.
authors: Xiaojian
authors: X
authors: Kang
authors: Human Cognitive Neurophysiology Lab, VA Research Service, VA-NCHCS, 150 Muir Road, Martinez, CA 94553, USA.
authors: E William
authors: EW
authors: Yund
authors: Beijing Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, PR China.
authors: Shanglian
authors: S
authors: Bao
authors: Human Cognitive Neurophysiology Lab, VA Research Service, VA-NCHCS, 150 Muir Road, Martinez, CA 94553, USA; Department of Neurology and Center for Neuroscience, 4860 Y St., Suite 3700, Sacramento, CA 95817, USA.
authors: David L
authors: DL
authors: Woods
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Cortex; Cortical surface; FA; MTR; T1/T2; Visual cortical fields