title: Flavonolignans and other constituents from Lepidium meyenii with activities in anti-inflammation and human cancer cell lines.
abstract: From the roots of Lepidium meyenii Walpers (Brassicaceae) have been isolated and identified 2 flavonolignans, tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (1) and tricin 4'-O-(erythro-β-guaiacyl-glyceryl) ether (2), along with 11 other known compounds, tricin (3), pinoresinol (4), 4-hydroxycinnamic acid (5), guanosine (6), glucotropaeolin (7), desulfoglucotropaeolin (8), 3-hydroxybenzylisothiocyanate (9), malic acid benzoate (10), 5-(hydroxymethyl)-2-furfural (11), d-phenylalanine (12), and vanillic acid 4-O-β-d-glucoside (13). Structures were elucidated on the basis of NMR and MS data. Some isolates and previously isolated lepidiline B (14) were tested for cytotoxicity in a small panel of human cancer cell lines (Hep G2, COLO 205, and HL-60) and for anti-inflammatory activities in LPS-treated RAW 264.7 macrophage. Among them, compounds 1 and 14 were modestly active for inhibiting nitrite production in macrophage. Compounds 1, 14, and 3 were demonstrated to be selectively active against HL-60 cells with IC50 values of 40.4, 52.0, and 52.1 μM, respectively.
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Pharmaceutical Engineering, Northwest University , Taibai North Road 229, Xi'an, Shaanxi, China 710069.
authors: Naisheng
authors: N
authors: Bai
authors: Kan
authors: K
authors: He
authors: Marc
authors: M
authors: Roller
authors: Ching-Shu
authors: CS
authors: Lai
authors: Lu
authors: L
authors: Bai
authors: Min-Hsiung
authors: MH
authors: Pan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D044947:Flavonolignans / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D029686:Lepidium / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D044947:Flavonolignans; D010936:Plant Extracts
keywords: Brassicaceae; Lepidium meyenii; anti-inflammatory; flavonoid; flavonolignans; human cancer cell lines (Hep G2, COLO 205, and HL-60); lignan; maca