title: Isolation and cytotoxicity evaluation of the chemical constituents from Cephalantheropsis gracilis.
abstract: Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl) phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines.
authors: Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan. cfchang@mail.cmu.edu.tw.
authors: Chi-Fen
authors: CF
authors: Chang
authors: Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. lynn4051@yahoo.com.tw.
authors: Yu-Lin
authors: YL
authors: Hsu
authors: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. cylee@mail.cmu.edu.tw.
authors: Chao-Ying
authors: CY
authors: Lee
authors: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. u101003312@cmu.edu.tw.
authors: Chia-Hua
authors: CH
authors: Wu
authors: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. yachwu@mail.cmu.edu.tw.|Research Center for Chinese Herbal Medicine, China Medical University, Taichung 40402, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. yachwu@mail.cmu.edu.tw.|Center of Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan. yachwu@mail.cmu.edu.tw.
authors: Yang-Chang
authors: YC
authors: Wu
authors: School of Pharmacy, China Medical University, Taichung 40402, Taiwan. thchuang@mail.cmu.edu.tw.|Research Center for Chinese Herbal Medicine, China Medical University, Taichung 40402, Taiwan. thchuang@mail.cmu.edu.tw.
authors: Ta-Hsien
authors: TH
authors: Chuang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D029595:Orchidaceae / Q000737:chemistry* / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts