title: Specific genetic features of Campylobacter jejuni strain G1 revealed by genome sequencing.
abstract: This report describes a draft genome sequence of Campylobacter jejuni strain G1. The strain contains no plasmids, despite being resistant to tetracycline (Tet). Comparison of the genome of this strain with that of a reference strain NCTC 11168 (Tet sensitive) revealed the presence of a candidate gene that may be responsible for antibiotic resistance, as well as the genes involved in the synthesis of ganglioside-mimicking molecules responsible for the development of a neurodegenerative disorder, Guillain-Barré syndrome.
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK.
authors: Burhan
authors: B
authors: Lehri
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK.
authors: Kushneet
authors: K
authors: Kukreja
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK.
authors: Ana
authors: A
authors: Vieira
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK.
authors: Milena
authors: M
authors: Zaremba
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK.
authors: Kwasi
authors: K
authors: Bonney
authors: School of Life Sciences, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK a.karlyshev@kingston.ac.uk.
authors: Andrey V
authors: AV
authors: Karlyshev
mesh_terms: D001483:Base Sequence; D016123:Campylobacter jejuni / Q000187:drug effects / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005732:Gangliosides / Q000378:metabolism; D016680:Genome, Bacterial; D020275:Guillain-Barre Syndrome / Q000382:microbiology; D006801:Humans; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA; D013753:Tetracycline Resistance / Q000235:genetics*
chemical_list: D005732:Gangliosides
keywords: Guillaine–Barré syndrome; ganglioside mimicry; lipo-oligosaccharide; multidrug efflux pump; tetracycline resistance