title: Patient factors may predict anastomotic complications after rectal cancer surgery: Anastomotic complications in rectal cancer.
abstract: OBJECTIVE
  Anastomotic complications following rectal cancer surgery occur with varying frequency. Preoperative radiation, BMI, and low anastomoses have been implicated as predictors in previous studies, but their definitive role is still under review. The objective of our study was to identify patient and operative factors that may be predictive of anastomotic complications.
  
  
  METHODS
  A retrospective review was performed on patients who had sphincter-preservation surgery performed for rectal cancer at a tertiary medical center between 2005 and 2011.
  
  
  RESULTS
  123 patients were included in this study, mean age was 59 (26-86), 58% were male. There were 33 complications in 32 patients (27%). Stenosis was the most frequent complication (24 of 33). 11 patients required mechanical dilatation, and 4 had operative revision of the anastomosis. Leak or pelvic abscess were present in 9 patients (7.3%); 4 were explored, 2 were drained and 3 were managed conservatively. 4 patients had permanent colostomy created due to anastomotic complications. Laparoscopy approach, BMI, age, smoking and tumor distance from anal verge were not significantly associated with anastomotic complications. After a multivariate analysis chemoradiation was significantly associated with overall anastomotic complications (Wall = 0.35, p = 0.05), and hemoglobin levels were associated with anastomotic leak (Wald = 4.09, p = 0.04).
  
  
  CONCLUSIONS
  Our study identifies preoperative anemia as possible risk factor for anastomotic leak and neoadjuvant chemoradiation may lead to increased risk of complications overall. Further prospective studies will help to elucidate these findings as well as identify amenable factors that may decrease risk of anastomotic complications after rectal cancer surgery.
authors: Department of Colorectal Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
authors: Dana M
authors: DM
authors: Hayden
authors: Department of Colorectal Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
authors: Maria C
authors: MC
authors: Mora Pinzon
authors: Department of General Surgery (Section of Colon & Rectal Surgery), Rush University Medical Center, Chicago, IL 60612, USA.
authors: Amanda B
authors: AB
authors: Francescatti
authors: Department of Colorectal Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
authors: Theodore J
authors: TJ
authors: Saclarides
keywords: Leak; Low anterior resection; Rectal cancer; Stenosis