title: Autoimmune thrombocytopenia: a complication of fludarabine therapy in the treatment of Waldenstrom's macroglobulinemia.
abstract: Fludarabine is an effective purine analogue which has become extensive used in lymph proliferative malignancies. However, an increased incidence of autoimmune disorders including autoimmune hemolytic anemia (AHIA) and idiopathic thrombocytopenia (ITP) is reported with the use of fludarabine. The exact mechanism for fludarabine to exacerbate thrombocytopenia is not distinct. In our report, we describe a patient with WM developed a refractory, life-threatening and fludarabine-associated thrombocytopenia which could not be explained by the cytotoxic effects of fludarabine. Possible mechanisms of fludarabine on autoimmune disorders are discussed.
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Yujie
authors: Y
authors: Jiang
authors: Institute of Shandong Medical Imaging, Shandong University Jinan, Shandong, China.
authors: Hongjuan
authors: H
authors: Peng
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Xin
authors: X
authors: Cui
authors: Department of Radiology, No.4 Hospital of Jinan City Jinan, Shandong, China.
authors: Ying
authors: Y
authors: Zhou
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Dai
authors: D
authors: Yuan
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Xiaohui
authors: X
authors: Sui
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Lingyan
authors: L
authors: Zhang
authors: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors: Hongzhi
authors: H
authors: Xu
keywords: Fludarabine; Waldenstrom’s macroglobulinemia; thrombocytopenia