title: Salmonella-how a metabolic generalist adopts an intracellular lifestyle during infection.
abstract: The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.
authors: Department of Bioinformatics, Biocenter, University of Würzburg Würzburg, Germany.
authors: Thomas
authors: T
authors: Dandekar
authors: Department of Bioinformatics, Biocenter, University of Würzburg Würzburg, Germany.
authors: Astrid
authors: A
authors: Fieselmann
authors: Department of Bioinformatics, Biocenter, University of Würzburg Würzburg, Germany.
authors: Eva
authors: E
authors: Fischer
authors: Division of Microbiology, Biology/Chemistry, University of Osnabrück Osnabrück, Germany.
authors: Jasmin
authors: J
authors: Popp
authors: Division of Microbiology, Biology/Chemistry, University of Osnabrück Osnabrück, Germany.
authors: Michael
authors: M
authors: Hensel
authors: Division of Microbiology, Biology/Chemistry, University of Osnabrück Osnabrück, Germany.
authors: Janina
authors: J
authors: Noster
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D012480:Salmonella Infections / Q000382:microbiology*; D019779:Salmonella enterica / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins
keywords: Salmonella-containing vacuole (SCV); metabolism; regulation; virulence; “-omics”