title: Chemical constituents and biological activities of the genus Linaria (Scrophulariaceae).
abstract: This is a review on 95 references dealing with the genus Linaria (Scrophularioideae-Antirrhineae tribe), a known genus of the Scrophulariaceae family, which comprises about 200 species mainly distributed in Europe, Asia and North Africa. The use of some Linaria species in folk medicine has attracted the attention for chemical and biological studies. This report is aimed to be a comprehensive overview on the isolated or identified known and often new metabolites from the 41 Linaria species so far cited. It is organised presenting first the phytochemical classes of alkaloids, polyphenols including flavonoids, the latter being quite diffused and mostly present as flavones, flavonols and their glycosides, and terpenoids including iridoids and steroids. Second, the results from biological investigation on plant extracts, pure natural products isolated from Linaria species and some synthetic derivatives are reported, with antitumour, anti-acetylcholinesterase, anti-inflammatory and analgesic, antioxidant and antibacterial activities.
authors: a Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL) , Université Constantine 1, Algérie.
authors: Thamere
authors: T
authors: Cheriet
authors: Ines
authors: I
authors: Mancini
authors: Ramdane
authors: R
authors: Seghiri
authors: Fadila
authors: F
authors: Benayache
authors: Samir
authors: S
authors: Benayache
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032221:Linaria / Q000737:chemistry*; D008519:Medicine, Traditional; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D005419:Flavonoids; D064209:Phytochemicals; D010936:Plant Extracts; D059808:Polyphenols; D013729:Terpenes
keywords: Linaria plants; Scrophulariaceae; biological activities; phytochemical