title: Epithelial morphogenesis: the mouse eye as a model system.
abstract: Morphogenesis is the developmental process by which tissues and organs acquire the shape that is critical to their function. Here, we review recent advances in our understanding of the mechanisms that drive morphogenesis in the developing eye. These investigations have shown that regulation of the actin cytoskeleton is central to shaping the presumptive lens and retinal epithelia that are the major components of the eye. Regulation of the actin cytoskeleton is mediated by Rho family GTPases, by signaling pathways and indirectly, by transcription factors that govern the expression of critical genes. Changes in the actin cytoskeleton can shape cells through the generation of filopodia (that, in the eye, connect adjacent epithelia) or through apical constriction, a process that produces a wedge-shaped cell. We have also learned that one tissue can influence the shape of an adjacent one, probably by direct force transmission, in a process we term inductive morphogenesis. Though these mechanisms of morphogenesis have been identified using the eye as a model system, they are likely to apply broadly where epithelia influence the shape of organs during development.
authors: Division of Pediatric Ophthalmology and Strabismus, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors: Bharesh
authors: B
authors: Chauhan
authors: College of Optometry, The Ohio State University, Columbus, Ohio, USA.
authors: Timothy
authors: T
authors: Plageman
authors: Department of Chemistry and Physics, Lamar University, Beaumont, Texas, USA.
authors: Ming
authors: M
authors: Lou
authors: The Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Department of Ophthalmology, University of Cincinnati and Children's Hospital Research Foundation, Cincinnati, Ohio, USA. Electronic address: richard.lang@cchmc.org.
authors: Richard
authors: R
authors: Lang
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology*; D000818:Animals; D048430:Cell Shape / Q000502:physiology*; D005123:Eye / Q000196:embryology*; D051379:Mice; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D055213:Retinal Pigment Epithelium / Q000166:cytology / Q000196:embryology*
keywords: Apical constriction; Cytoskeleton; Eye cup; Filopodia; GTPase; Lamellipodia; Lens placode; Morphogenesis