title: Is Normocalcemic Primary Hyperparathyroidism Harmful or Harmless?
abstract: BACKGROUND
  Primary hyperparathyroidism (PHPT) is reported to be associated with an increased frequency of hypertension, however, information in this regard is sparse in relation to normocalcemic primary hyperparathyroidism (NPHPT).
  
  
  OBJECTIVE
  The aim of this study was to determine the association between NPHPT and blood pressure.
  
  
  METHODS
  We retrospectively enrolled 940 patients who visited the Fujian Provincial Hospital between September 2010 and December 2013 with a measured serum parathyroid hormone (PTH) and calcium level. Among them, 11 patients were diagnosed with NPHPT, while 296 cases with normal PTH and albumin-adjusted serum calcium.
  
  
  METHODS
  Systolic blood pressure (SBP), diastolic blood pressure (DBP), intact serum PTH, and serum calcium were recorded.
  
  
  RESULTS
  There were no significant differences between subjects identified with NPHPT and those with normal PTH in terms of age, sex, body mass index, serum calcium, 25-Hydroxyvitamin D, serum creatinine, fasting plasma glucose, triglycerides, total cholesterol, high density lipoprotein, and low density lipoprotein. The subjects with a diagnosis of NPHPT had higher levels of SBP (141.9 ± 20.2 vs 131.2 ± 16.5, P = .041) and DBP (85.2 ± 12.4 vs 76.8 ± 10.3, P = .026) than the subjects in the cohort with normal PTH. After adjustment for all potential confounders, risks (odds ratios and 95% confidence interval) of SBP and DBP in NPHPT patients were 1.035 (1.000, 1.071) and 1.063 (1.004, 1.125), respectively (P < .05).
  
  
  CONCLUSIONS
  The NPHPT had higher risk of high blood pressure than subjects with normal PTH. It is worth considering the necessity of more aggressive therapeutic intervention aimed to normalize PTH even if patients with NPHPT continue to be normocalcemic.
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Gang
authors: G
authors: Chen
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Ying
authors: Y
authors: Xue
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Qiongyao
authors: Q
authors: Zhang
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Ting
authors: T
authors: Xue
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Jin
authors: J
authors: Yao
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Huibin
authors: H
authors: Huang
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Jixing
authors: J
authors: Liang
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Liantao
authors: L
authors: Li
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Wei
authors: W
authors: Lin
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Lixiang
authors: L
authors: Lin
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Lidan
authors: L
authors: Shi
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Liangchun
authors: L
authors: Cai
authors: Department of Endocrinology (G.C., Y.X., T.X., J.Y., H.H., J.L., L.Li., W.L., L.Lin., L.S., L.C., J.W.), Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou,350001, China; and Department of Information (Q.Z.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.
authors: Junping
authors: J
authors: Wen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002118:Calcium / Q000097:blood*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011379:Prognosis; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium