title: Short-term effects of particulate matters on pulse pressure in two general population studies.
abstract: OBJECTIVE
  To explore the association of short-term exposure to particulate matter with aerodynamic diameters less than 10 μm (PM10) with pulse pressure, SBP, and DBP taking outdoor temperature into account in two large population-based studies in Switzerland.
  
  
  METHODS
  We used data from the Bus Santé study including 5605 adults in Geneva and the CoLaus study including 6183 adults in Lausanne. PM10 and meteorological data were measured from fixed monitoring stations. We analyzed the association of short-term exposure to PM10 (on the day of examination visit and up to 7 days before) with pulse pressure, SBP, and DBP by linear regression, controlling for potential confounders and effect modifiers.
  
  
  RESULTS
  Average PM10 levels were 22.4 μg/m in Geneva and 31.7 μg/m in Lausanne. In adjusted models, for each 10 μg/m increase in 7-day PM10 average, pulse pressure and SBP increased by 0.583 (95% confidence interval, 0.296-0.870) mmHg and 0.490 (0.056-0.925) mmHg in Geneva, and 0.183 (0.017-0.348) mmHg and 0.036 (0.042-0.561) mmHg in Lausanne, respectively. Stronger associations of pulse pressure and SBP with PM10 were observed when outdoor temperature was above 5°C.
  
  
  CONCLUSIONS
  Positive associations of pulse pressure and SBP with short-term exposure to PM10 were found and replicated in the Swiss adult population. Our results suggest that even low levels of air pollution may substantially impact cardiovascular risk in the general population.
authors: aInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital (CHUV), Lausanne bUnit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland cDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA dInstitute for Work and Health (IST), Epalinges, Switzerland eIOM Singapore Pte Ltd, Chevron House, Singapore fDepartment of Medicine, Internal Medicine, CHUV, Lausanne, Switzerland.
authors: Dai-Hua
authors: DH
authors: Tsai
authors: Idris
authors: I
authors: Guessous
authors: Michael
authors: M
authors: Riediker
authors: Fred
authors: F
authors: Paccaud
authors: Jean-Michel
authors: JM
authors: Gaspoz
authors: Jean-Marc
authors: JM
authors: Theler
authors: Gerard
authors: G
authors: Waeber
authors: Peter
authors: P
authors: Vollenweider
authors: Murielle
authors: M
authors: Bochud
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000633:toxicity*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D052638:Particulate Matter / Q000633:toxicity*; D012307:Risk Factors; D013557:Switzerland; D013696:Temperature; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter