title: The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer.
abstract: Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC-TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG and GC, three that distinguished NAG from DU, and eight that differed between DU and GC. The IgG glycosylation signature may be useful as a predictive marker for gastric cancer.
authors: Department of Chemistry, University of California, Davis, CA, 95616.
authors: L Renee
authors: LR
authors: Ruhaak
authors: Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089.
authors: Donald A
authors: DA
authors: Barkauskas
authors: Infectious Diseases Research Unit, Instituto Mexicano del Seguro Social, Mexico.
authors: Javier
authors: J
authors: Torres
authors: Departments of Medicine and Microbiology & Immunology; Center for Comparative Medicine, University of California, Davis School of Medicine, Davis, CA, 95616.
authors: Cara L
authors: CL
authors: Cooke
authors: Department of Chemistry, University of California, Davis, CA, 95616.
authors: Lauren D
authors: LD
authors: Wu
authors: Department of Chemistry, University of California, Davis, CA, 95616.
authors: Carol
authors: C
authors: Stroble
authors: Department of Chemistry, University of California, Davis, CA, 95616.
authors: Sureyya
authors: S
authors: Ozcan
authors: Department of Chemistry, University of California, Davis, CA, 95616.
authors: Cynthia C
authors: CC
authors: Williams
authors: Infectious Diseases Research Unit, Instituto Mexicano del Seguro Social, Mexico.
authors: Margarita
authors: M
authors: Camorlinga
authors: Department of Biomedical Engineering, University of California, Davis, CA, 95616 ; Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA, 95616.
authors: David M
authors: DM
authors: Rocke
authors: Department of Chemistry, University of California, Davis, CA, 95616 ; Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616.
authors: Carlito B
authors: CB
authors: Lebrilla
authors: Departments of Medicine and Microbiology & Immunology; Center for Comparative Medicine, University of California, Davis School of Medicine, Davis, CA, 95616.
authors: Jay V
authors: JV
authors: Solnick
keywords: Gastric cancer; N-glycan; duodenal ulcer; gastritis; nanoLC-MS; serum