title: Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time-kill assay. The MIC of ORV for all strains was moderate at 125 µg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non-growth inhibitory dose of certain antibiotics. Time-kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Dae-Ki
authors: DK
authors: Joung
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Sung-Hoon
authors: SH
authors: Choi
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Ok-Hwa
authors: OH
authors: Kang
authors: BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Sung-Bae
authors: SB
authors: Kim
authors: BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Su-Hyun
authors: SH
authors: Mun
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Yun-Soo
authors: YS
authors: Seo
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Da-Hye
authors: DH
authors: Kang
authors: BK21 Plus Team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Ryong
authors: R
authors: Gong
authors: Department of Oriental Medicine Resources, Sunchon National University, Sunchon, Jeonnam 540‑742, Republic of Korea.
authors: Dong-Won
authors: DW
authors: Shin
authors: Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea.
authors: Youn-Chul
authors: YC
authors: Kim
authors: College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570‑749, Republic of Korea.
authors: Dong-Yeul
authors: DY
authors: Kwon
mesh_terms: D000904:Antibiotics, Antitubercular / Q000008:administration & dosage; D002939:Ciprofloxacin / Q000008:administration & dosage; D004357:Drug Synergism; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D010936:Plant Extracts / Q000008:administration & dosage*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D000904:Antibiotics, Antitubercular; D005839:Gentamicins; D010936:Plant Extracts; D013267:Stilbenes; C034912:puag-haad; D002939:Ciprofloxacin