title: Silane surface modification for improved bioadhesion of esophageal stents.
abstract: Stent migration occurs in 10-40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.
authors: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
authors: Mert
authors: M
authors: Karakoy
authors: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
authors: Evin
authors: E
authors: Gultepe
authors: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
authors: Shivendra
authors: S
authors: Pandey
authors: Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
authors: Mouen A
authors: MA
authors: Khashab
authors: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
authors: David H
authors: DH
authors: Gracias
keywords: Self-assembled monolayer; coating; gastrointestinal; proteins; pull-force