title: Levels of transforming growth factor β1 during first six months of peritoneal dialysis.
abstract: Transforming-growth factor β1 (TGF-β1) is a powerful cytokine involved in physiological processes of growth, differentiation, gene expression, embryogenesis, tissue remodelling, wound healing as well as tumorigenesis, immunosuppression and fibrosis, like peritoneal membrane fibrosis on long-term peritoneal dialysis (PD) treatment. The aims of this study were to determine TGF-β1 levels in serum (s) and drained dialysate (dd), to assess their relations to sex, age, diabetes, dialysis modality, peritonitis and use of erythropoiesis stimulating agents (ESAs), inhibitors of angiotensin-converting enzyme (ACEi) and/or statins in 20 patients, 11 men and 9 women, mean age 62.90 ± 12.69 years, free of peritonitis during the first 6 months of PD treatment. There was no statistically significant difference in TGF-β1 concentrations in serum and drained dialysate at the beginning and after first 6 months of chronic PD, in patients of different sex, age and diabetic patients versus non-diabetic. The significant positive correlations between sTGF-β1 levels and glycemia at the beginning and cholesterolemia after 6 months of PD treatment suggest higher TGF-β1 concentrations in patients with unfavorable metabolic profile. Expression of TGF-β1 in effluent dialysate was significantly lower in patients on chronic PD using ACEi therapy, suggesting ACEi to have a protective effect on peritoneal membrane. Patients on ESA had slightly lower sTGF-β1 concentrations after the first 6 months of PD treatment.
authors: Clinic of Nephrology, Clinical Center of Serbia, School of Medicine, University of Belgrade , Belgrade , Serbia .
authors: Biljana
authors: B
authors: Stojimirović
authors: Nataša
authors: N
authors: Jovanović
authors: Jasna
authors: J
authors: Trbojević-Stanković
authors: Dejan M
authors: DM
authors: Nešić
authors: Tanja
authors: T
authors: Brašanac
authors: Snežana
authors: S
authors: Žunić-Božinovski
mesh_terms: D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000032:analysis* / Q000097:blood
chemical_list: D015314:Dialysis Solutions; D053773:Transforming Growth Factor beta1
keywords: Inhibitors of angiotensin-converting enzyme; TGF-β1; patients; peritoneal dialysis; statins