title: Detection of early changes in the parahippocampal and posterior cingulum bundles during mild cognitive impairment by using high-resolution multi-parametric diffusion tensor imaging.
abstract: We aimed to determine alterations occurring in the parahippocampal cingulum bundle (PhC) and posterior cingulum bundle (PoC) in patients with mild cognitive impairment (MCI) through analysis of high-resolution multi-parametric diffusion tensor imaging (DTI). Participants comprised 41 patients with MCI (21 AD converters [MCI-C] and 20 non-converters [MCI-NC]), 20 patients with Alzheimer׳s disease (AD), and 26 healthy elderly subjects who underwent prospective examination with high-resolution DTI. An atlas-based regions-of-interest (ROIs) method calculated fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (DA), and radial diffusivity (DR) in the PhC and PoC. For the PhC, FA values showed significant decreases, and MD and DR values showed significantly increases, in the MCI-C and AD groups compared with the healthy controls, although the MCI-C and MCI-NC groups did not differ significantly in these metrics. Conversely, none of the diffusion metrics for the PoC showed a significant difference among the MCI groups and the control groups, although there were significant differences between the AD group and control groups. High-resolution multi-parametric DTI analysis was able to detect substantial changes in diffusion anisotropy and diffusivity in the PhC of patients with MCI who were destined to convert to AD.
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan. Electronic address: keito@iwate-med.ac.jp.
authors: Kenji
authors: K
authors: Ito
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan.
authors: Makoto
authors: M
authors: Sasaki
authors: Department of Neurology and Gerontology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
authors: Junko
authors: J
authors: Takahashi
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan.
authors: Ikuko
authors: I
authors: Uwano
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan.
authors: Fumio
authors: F
authors: Yamashita
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan.
authors: Satomi
authors: S
authors: Higuchi
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan.
authors: Jonathan
authors: J
authors: Goodwin
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan; Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14 W5 Kita-ku, Sapporo, Hokkaido 060-8648, Japan.
authors: Taisuke
authors: T
authors: Harada
authors: Division of Ultra-high Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan; Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14 W5 Kita-ku, Sapporo, Hokkaido 060-8648, Japan.
authors: Kohsuke
authors: K
authors: Kudo
authors: Department of Neurology and Gerontology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.
authors: Yasuo
authors: Y
authors: Terayama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D016880:Anisotropy; D060825:Cognitive Dysfunction / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
keywords: Alzheimer׳s disease; Diffusion tensor imaging; Mild cognitive impairment; Parahippocampal cingulum bundle; Posterior cingulum bundle