title: Association of uric acid, atherogenic index of plasma and albuminuria in diabetes mellitus.
abstract: BACKGROUND
  The associations of serum uric acid (UA), atherogenic index of plasma (AIP) and albuminuria with cardiovascular disease have been shown. Several studies focused on association of serum UA and dyslipidemia, serum UA and renal impairment, dyslipidemia and renal impairment. However, to date, in literature, there have been no studies demonstrating the relationship between these parameters in diabetic patients together.
  
  
  OBJECTIVE
  We aimed to investigate the association between serum UA, albuminuria and AIP in diabetic patients.
  
  
  METHODS
  This was a retrospective study involving data of 645 diabetic patients. The patients were separated into groups according to their serum uric acid and AIP levels. The quantitative urine albumin/creatinine ratio in morning spot urine samples were used for standard albuminuria determination. Serum uric acid levels under 6 mg/dL were considered as normal. AIP was calculated as the logarithmically transformed ratio of triglyceride to high density lipoprotein cholesterol.
  
  
  RESULTS
  AIP and albuminuria levels were high in high serum UA group compared to normal UA group. Uric acid and albuminuria tended to increase with increasing AIP. Correlation analysis showed that albuminuria, AIP and UA were significantly correlated with each other. Additionally, in binary logistic regression analysis, AIP was found to be independently associated with high UA levels.
  
  
  CONCLUSIONS
  Present study reveals that serum UA, AIP and albuminuria are closely related. Physicians should be aware that patients with concomitant hyperuricemia, albuminuria and high AIP are at increased risk of developing cardiovascular disease. Our study confirms that there is a need for larger prospective studies to determine the mechanisms underlying the association of serum UA, AIP and albuminuria.
authors: Department of Endocrinology, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
authors: Emin Murat
authors: EM
authors: Akbas
authors: Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
authors: Aysu
authors: A
authors: Timuroglu
authors: Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
authors: Adalet
authors: A
authors: Ozcicek
authors: Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
authors: Fatih
authors: F
authors: Ozcicek
authors: Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
authors: Levent
authors: L
authors: Demirtas
authors: Department of Endocrinology, School of Medicine, Ataturk University Erzurum, Turkey.
authors: Adem
authors: A
authors: Gungor
authors: Department of Biochemistry, School of Medicine, Ataturk University Erzurum, Turkey.
authors: Nergis
authors: N
authors: Akbas
keywords: Uric acid; albuminuria; atherogenic index of plasma