title: Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography.
abstract: The aim of this study was to investigate cardiac involvement in patients with idiopathic inflammatory myopathies excluding inclusion body myositis with cardiac magnetic resonance tomography (CMR). A case series of 53 patients with polymyositis, dermatomyositis, or non-specific myositis underwent CMR including functional imaging, T1-weighted, and late gadolinium enhancement (LGE) imaging. T1-weighted and LGE images were analyzed for myocardial enhancement. Reduced left ventricular function (LVF) was found in 9 (7%) patients. Patients with reduced LVF more often presented with early and late myocardial enhancement (p = 0.014 and p = 0.001). In 33 (62.3%) patients, LGE was observed by CMR. These patients had significantly lower left ventricular ejection fractions (p < 0.001) compared to patients without LGE. LGE was mainly present in the lateral (p < 0.01) and inferior (p < 0.02) segments. No correlations of LGE presence or reduced LVF to cardiovascular risk factors were found. Myocardial inflammation is very frequent in polymyositis, dermatomyositis, and non-specific myositis. In our patient, cohort CMR demonstrated signs of myocardial inflammation in 62.3%. CMR seems to offer a measurable and quantifiable diagnostic tool for cardiac involvement of idiopathic inflammatory myopathies and can thus be used to monitor disease progress and therapeutic success in these patients.
authors: Department of Neurology, University of Ulm, Ulm, Germany.
authors: Angela
authors: A
authors: Rosenbohm
authors: Dominik
authors: D
authors: Buckert
authors: Nora
authors: N
authors: Gerischer
authors: Thomas
authors: T
authors: Walcher
authors: Jan
authors: J
authors: Kassubek
authors: Wolfgang
authors: W
authors: Rottbauer
authors: Albert C
authors: AC
authors: Ludolph
authors: Peter
authors: P
authors: Bernhardt
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D042241:Early Diagnosis; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005682:Gadolinium / Q000378:metabolism; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009220:Myositis / Q000097:blood / Q000175:diagnosis*; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D020097:Natriuretic Peptide, Brain; D005682:Gadolinium; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases