title: Outcomes after autologous SCT in lymphoma patients grouped by weight.
abstract: Obesity continues to be an increasing global health issue contributing to the complexity of chemotherapy dosing in the field of SCT. Investigation into the optimal dosing weight used to calculate chemotherapy doses in obese patients undergoing SCT is limited and inconclusive. Our single-center, retrospective study compared safety and efficacy outcomes by body mass index (BMI) for 476 adult lymphoma patients who underwent auto-SCT with a myeloablative chemotherapeutic regimen of BU, CY and etoposide dosed using adjusted body weight. Three weight groups categorized based on BMI were defined: normal/underweight ⩽24.9 kg/m(2), overweight 25-29.9 kg/m(2) and obese ⩾30 kg/m(2). Severity of mucositis, incidence of secondary malignancy, incidence of bacteremia and median hospital length of stay did not differ among the groups. The median times to absolute neutrophil count and platelet recovery were 10 days (P=0.75) and 14 days (P=0.17), respectively. Obese patients had a lower 100-day mortality compared with other weight groups, although this did not translate into an OS benefit. OS and disease relapse were similar among the groups. Our study demonstrates that use of adjusted body weight to calculate chemotherapy doses does not negatively have an impact on outcomes in obese patients undergoing auto-SCT with BU, CY and etoposide.
authors: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors: J E
authors: JE
authors: Lau
authors: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors: C
authors: C
authors: Weber
authors: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors: M
authors: M
authors: Earl
authors: Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
authors: L A
authors: LA
authors: Rybicki
authors: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors: K D
authors: KD
authors: Carlstrom
authors: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors: C M
authors: CM
authors: Wenzell
authors: Blood & Marrow Transplant Program, Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland, OH, USA.
authors: B T
authors: BT
authors: Hill
authors: Blood & Marrow Transplant Program, Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland, OH, USA.
authors: N S
authors: NS
authors: Majhail
authors: Blood & Marrow Transplant Program, Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland, OH, USA.
authors: M
authors: M
authors: Kalaycio
mesh_terms: D000328:Adult; D000368:Aged; D064592:Autografts; D001835:Body Weight; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000008:administration & dosage*; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000379:methods*
chemical_list: D019653:Myeloablative Agonists