title: Skeletal muscle fatigue and decreased efficiency: two sides of the same coin?
abstract: During high-intensity submaximal exercise, muscle fatigue and decreased efficiency are intertwined closely, and each contributes to exercise intolerance. Fatigue and muscle inefficiency share common mechanisms, for example, decreased "metabolic stability," muscle metabolite accumulation, decreased free energy of adenosine triphosphate breakdown, limited O2 or substrate availability, increased glycolysis, pH disturbance, increased muscle temperature, reactive oxygen species production, and altered motor unit recruitment patterns.
authors: 1 Exercise Physiology Laboratory, Department of Medical and Biological Sciences, University of Udine, Udine, Italy; 2 Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA; and 3 Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Kraków, Poland.
authors: Bruno
authors: B
authors: Grassi
authors: Harry B
authors: HB
authors: Rossiter
authors: Jerzy A
authors: JA
authors: Zoladz
mesh_terms: D001833:Body Temperature Regulation; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology; D017079:Exercise Tolerance / Q000502:physiology*; D006019:Glycolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009119:Muscle Contraction; D018763:Muscle Fatigue / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D010101:Oxygen Consumption; D017382:Reactive Oxygen Species / Q000378:metabolism; D011999:Recruitment, Neurophysiological
chemical_list: D017382:Reactive Oxygen Species