title: Statistical inference on genetic data reveals the complex demographic history of human populations in central Asia.
abstract: The demographic history of modern humans constitutes a combination of expansions, colonizations, contractions, and remigrations. The advent of large scale genetic data combined with statistically refined methods facilitates inference of this complex history. Here we study the demographic history of two genetically admixed ethnic groups in Central Asia, an area characterized by high levels of genetic diversity and a history of recurrent immigration. Using Approximate Bayesian Computation, we infer that the timing of admixture markedly differs between the two groups. Admixture in the traditionally agricultural Tajiks could be dated back to the onset of the Neolithic transition in the region, whereas admixture in Kyrgyz is more recent, and may have involved the westward movement of Turkic peoples. These results are confirmed by a coalescent method that fits an isolation-with-migration model to the genetic data, with both Central Asian groups having received gene flow from the extremities of Eurasia. Interestingly, our analyses also uncover signatures of gene flow from Eastern to Western Eurasia during Paleolithic times. In conclusion, the high genetic diversity currently observed in these two Central Asian peoples most likely reflects the effects of recurrent immigration that likely started before historical times. Conversely, conquests during historical times may have had a relatively limited genetic impact. These results emphasize the need for a better understanding of the genetic consequences of transmission of culture and technological innovations, as well as those of invasions and conquests.
authors: Laboratoire d'Eco-Anthropologie et Ethnobiologie, UMR 7206, Muséum National d'Histoire Naturelle-Centre National de la Recherche Scientifique-Université Paris 7 Diderot, Paris, France palstra@mnhn.fr.
authors: Friso P
authors: FP
authors: Palstra
authors: Laboratoire d'Eco-Anthropologie et Ethnobiologie, UMR 7206, Muséum National d'Histoire Naturelle-Centre National de la Recherche Scientifique-Université Paris 7 Diderot, Paris, France.
authors: Evelyne
authors: E
authors: Heyer
authors: Laboratoire d'Eco-Anthropologie et Ethnobiologie, UMR 7206, Muséum National d'Histoire Naturelle-Centre National de la Recherche Scientifique-Université Paris 7 Diderot, Paris, France.
authors: Frédéric
authors: F
authors: Austerlitz
mesh_terms: D001209:Asia, Central; D044466:Asian People / Q000235:genetics*; D001499:Bayes Theorem; D003710:Demography; D051456:Gene Flow; D056426:Genetic Loci; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D018895:Microsatellite Repeats; D008957:Models, Genetic; D058974:Phylogeography; D017422:Sequence Analysis, DNA
chemical_list: D005819:Genetic Markers
keywords: Bayesian inference; human demography; population genetics