title: [Retinal and trabecular degeneration in glaucoma: new insights into pathogenesis and treatment].
abstract: Academic and industrial research has brought new insights into the pathogenesis of glaucoma, aiming at identifying and targeting specific mechanisms to improve our current therapeutic strategy. Retinal neurodegeneration is still the main focus, whether in terms of extrinsic factors such as neurotrophin deprivation, glutamate toxicity, vascular deficiency and neuro-inflammation from glial cells, or in terms of retinal ganglion cell intrinsic sensibility to proapoptotic signals. However, glaucoma is not solely a retinal disease but also involves retinal and trabecular meshwork degeneration, extending into and/or even originating from the brain. The present review summarizes our current knowledge of key mechanisms involved in glaucoma degeneration, focusing on the direction of current research towards the future of glaucoma therapy.
authors: Centre hospitalier national d'ophtalmologie des Quinze-Vingt, 28, rue de Charenton, 75012 Paris, France; Inserm CIC 503, centre d'investigation clinique, 28, rue de Charenton, 75012 Paris, France; Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France. Electronic address: alexandre.denoyer@gmail.com.
authors: A
authors: A
authors: Denoyer
authors: Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France.
authors: C
authors: C
authors: Roubeix
authors: Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France.
authors: A
authors: A
authors: Sapienza
authors: Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France.
authors: A
authors: A
authors: Réaux-Le Goazigo
authors: Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France.
authors: S
authors: S
authors: Mélik-Parsadaniantz
authors: Centre hospitalier national d'ophtalmologie des Quinze-Vingt, 28, rue de Charenton, 75012 Paris, France; Inserm CIC 503, centre d'investigation clinique, 28, rue de Charenton, 75012 Paris, France; Inserm U968, UPMC UMRS 968, CNRS UMR 7210, institut de la Vision, 17, rue Moreau, 75012 Paris, France; Hôpital Ambroise-Paré, AP-HP, université de Versailles-Saint-Quentin-en-Yvelines, 9, avenue Charles-de-Gaulle, 92104 Boulogne-Billancourt, France.
authors: C
authors: C
authors: Baudouin
mesh_terms: D005901:Glaucoma / Q000150:complications*; D006801:Humans; D012160:Retina; D012162:Retinal Degeneration / Q000209:etiology* / Q000628:therapy*; D014129:Trabecular Meshwork
keywords: Apoptose; Apoptosis; Glaucoma; Glaucome; Neurodegeneration; Neurodégénérescence; Neuroprotection; Trabecular meshwork; Trabéculum