title: The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). However, the association between mTOR/p-mTOR expression and NSCLC patients' prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSCLC was conducted.
  
  
  METHODS
  A systemically literature search was performed via Pubmed, Embase, Medline as well as CNKI (China National Knowledge Infrastructure). Studies were included that reported the hazard ratio (HR) and 95%CI for the association between mTOR/p-mTOR expression and NSCLC patients' survival. Random-effects model was used to pool HRs.
  
  
  RESULTS
  Ten eligible studies were included in this meta-analysis, with 4 about m-TOR and 7 about p-mTOR. For mTOR, the pooled HR of overall survival (OS) was 1.00 (95%CI 0.5 to 1.99) by univariate analysis and 1.22 (95%CI 0.53 to 2.82) by multivariate analysis. For p-mTOR, the pooled HR was 1.39 (95%CI 0.97 to 1.98) by univariate analysis and 1.42 (95%CI 0.56 to 3.60) by multivariate analysis.
  
  
  CONCLUSIONS
  The results indicated that no statistically significant association was found between mTOR/p-mTOR expression and NSCLC patients' prognosis.
authors: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Lei
authors: L
authors: Li
authors: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Dan
authors: D
authors: Liu
authors: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Zhi-Xin
authors: ZX
authors: Qiu
authors: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Shuang
authors: S
authors: Zhao
authors: Lab of Pathology, Department of Pathology, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Li
authors: L
authors: Zhang
authors: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors: Wei-Min
authors: WM
authors: Li
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D011379:Prognosis; D016019:Survival Analysis; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D010750:Phosphoproteins; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases