title: Doxorubicin-loaded mesoporous magnetic nanoparticles to induce apoptosis in breast cancer cells.
abstract: Selective targeting of chemotherapeutic drugs toward the cancer cells overcomes the limitations involved in chemotherapy. Ideally, targeted delivery system holds great potential in cancer therapy due to specific release of drug in the cancer tissues. In this regard, DOX-loaded chitosan coated mesoporous magnetic nanoparticles (DOX-CMMN) were prepared and evaluated for its physicochemical and biological characteristics. Nanosized magnetic nanoparticles were observed with a high loading capacity for DOX. The drug-loaded nanoparticles exhibited a controlled and sustained release of drug without any burst release phenomenon. The DOX-DMMN showed a concentration-dependent cell proliferation inhibitory action against breast cancer cells. The blank nanoparticles showed excellent biocompatibility with cell viability >85% at the maximum tested concentration. Our results showed that chitosan coated magnetic system has high potential for breast cancer targeting under an alternating current magnetic field (ACMF). The present study showed that magnetic nanoparticles can be targeted to tumor cells under the presence of oscillating magnetic field. The combined effect of chemotherapy and thermotherapy can have a promising clinical potential for the treatment of breast cancer.
authors: Department of General Surgery, Shandong University, Jinan, Shandong 250100, China; Department of General Surgery, Heze Municipal Hospital, Heze, Shandong 274000, China.
authors: Yan
authors: Y
authors: Zou
authors: Department of Pathology, Heze Medical College, Heze, Shandong 274000, China.
authors: Pin
authors: P
authors: Liu
authors: Department of Internal Medicine, Dingtao County Hospital, Heze, Shandong 274000, China.
authors: Chuan-He
authors: CH
authors: Liu
authors: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China. Electronic address: zhixuting6700@gmail.com.
authors: Xu-Ting
authors: XT
authors: Zhi
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001672:Biocompatible Materials / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology*; D048430:Cell Shape / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012542:Scattering, Radiation
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D004317:Doxorubicin; D048271:Chitosan
keywords: Anticancer effect; Breast cancer; Doxorubicin; Magnetic nanoparticles; Thermotherapy