title: An idiosyncratic reaction to clopidogrel.
abstract: Clopidogrel is an irreversible antiplatelet agent belonging to the thienopyridine group that acts to antagonize the adenosine diphosphate P2Y12 receptor on platelets. It thus inhibits the activation of platelet glycoprotein GPIIb/IIIa complex, which is essential for fibrinogen—platelet complex formation. Clopidogrel has widely replaced ticlopidine because of a much better clinical safety profile. Clopidogrel is a prodrug that requires hepatic activation to exert its antiplatelet effect. Hepatotoxicity with use of clopidogrel is a rare but clinically significant phenomenon. We report a case of clopidogrel-induced hepatotoxicity in an elderly white woman.
authors: Internist at East Tennessee State University in Johnson City. aaysha.dr@gmail.com.
authors: Aaysha
authors: A
authors: Kapila
authors: Fellow in Cardiovascular Medicine at Hartford Hospital in CT. lovids@hotmail.com.
authors: Lovely
authors: L
authors: Chhabra
authors: Internist at East Tennessee State University in Johnson City. zads46@goldmail.etsu.edu.
authors: Allison Diane
authors: AD
authors: Locke
authors: Gastroenterologist at East Tennessee State University in Johnson City. patelp1@mail.etsu.edu.
authors: Pranav
authors: P
authors: Patel
authors: Gastroenterologist at East Tennessee State University in Johnson City. khanna@mail.etsu.edu.
authors: Atul
authors: A
authors: Khanna
authors: Gastroenterologist at East Tennessee State University in Johnson City. chakram_reddy@hotmail.com.
authors: Chakradhar M
authors: CM
authors: Reddy
authors: Gastroenterologist at East Tennessee State University in Johnson City. young@mail.etsu.edu.
authors: Mark F
authors: MF
authors: Young
mesh_terms: D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine