title: Complete genome sequence of the fish pathogen Flavobacterium psychrophilum ATCC 49418(T.).
abstract: Flavobacterium psychrophilum is the causative agent of bacterial cold water disease and rainbow trout fry mortality syndrome in salmonid fishes and is associated with significant losses in the aquaculture industry. The virulence factors and molecular mechanisms of pathogenesis of F. psychrophilum are poorly understood. Moreover, at the present time, there are no effective vaccines and control using antimicrobial agents is problematic due to growing antimicrobial resistance and the fact that sick fish don't eat. In the hopes of identifying vaccine and therapeutic targets, we sequenced the genome of the type strain ATCC 49418 which was isolated from the kidney of a Coho salmon (Oncorhychus kisutch) in Washington State (U.S.A.) in 1989. The genome is 2,715,909 bp with a G+C content of 32.75%. It contains 6 rRNA operons, 49 tRNA genes, and is predicted to encode 2,329 proteins.
authors: Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
authors: Anson Kk
authors: AK
authors: Wu
authors: Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
authors: Andrew M
authors: AM
authors: Kropinski
authors: Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
authors: John S
authors: JS
authors: Lumsden
authors: Department of Biology, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
authors: Brian
authors: B
authors: Dixon
authors: Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.
authors: Janet I
authors: JI
authors: MacInnes
keywords: Aerobic; Bacterial cold water disease; Fish pathogen; Flavobacterium; Gram negative; Psychrotolerant; Rainbow trout fry mortality syndrome