title: Type 2 diabetes mellitus and the risk of hepatitis C virus infection: a systematic review.
abstract: The aim of this study was to evaluate the relationship between type 2 diabetes mellitus (T2DM) and hepatitis C virus (HCV) infection and to examine whether T2DM enhances the risk of HCV infection compared with the risk in the general population. We followed standard guidelines to perform a meta-analysis. The associated literature was selected based on the established inclusion criteria. The summary odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Through electronic database and manual searching, 22 studies were identified for the final analysis, which included a total of 78,051 individuals. Based on the random effects model, the meta-analysis results showed that patients with T2DM were at a higher risk of acquiring HCV infection than non-T2DM patients (summary OR = 3.50, 95% CI = 2.54-4.82, I(2) = 82.3%). Based on the current limited evidence, this study suggests that T2DM is associated with increased susceptibility to HCV infection.
authors: Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment &Food Safety, No. 1, Dali Road, Tianjin, 300050, China.
authors: Xuan
authors: X
authors: Guo
authors: Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment &Food Safety, No. 1, Dali Road, Tianjin, 300050, China.
authors: Min
authors: M
authors: Jin
authors: Department of Geriatrics, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, 610041, China.
authors: Ming
authors: M
authors: Yang
authors: Department of Occupational Health &Radiological Health; Zigong Center for Disease Control and Prevention, No. 1296, Huichuan Road Zigong, Sichuan 643000, China.
authors: Ke
authors: K
authors: Liu
authors: Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment &Food Safety, No. 1, Dali Road, Tianjin, 300050, China.
authors: Jun-wen
authors: JW
authors: Li
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004198:Disease Susceptibility; D006526:Hepatitis C / Q000209:etiology*; D006801:Humans; D012306:Risk