title: Polychlorinated biphenyls and polybrominated biphenyl ethers in adipose tissue and matched serum from an E-waste recycling area (Wenling, China).
abstract: To Date, the knowledge on relationship between PCBs/PBDEs exposure and thyroid hormones (THs) levels during pregnancy still needs to be extended. Meanwhile, studies on congener-specific adipose-serum ratios for PCBs/PBDEs were limited. This study reports the levels of PCBs/PBDEs in serum-adipose tissue samples (n = 64) from expectant women living surrounding e-waste recycling sites in Wenling, China. Their concentrations varied from several to hundreds of ng g(-1) lipid. Maternal exposure to PCBs was associated with lower TSH during pregnancy, suggesting possible implication for maternal health and fetal development. The compound levels between the adipose tissue and matched serum samples were highly correlated (p < 0.001), generating a predicted adipose-serum partitioning relationship for individual PCB congener and PBDE congener. Molecular characteristics, such as Kow value, molecular weight and molecular volume, may play a key role in the variable partitioning of some compounds between serum and adipose tissue.
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China.
authors: Quan-Xia
authors: QX
authors: Lv
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China; Beijing Technology and Business University, Beijing 100037, China.
authors: Wenyue
authors: W
authors: Wang
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China. Electronic address: lxhzpb@rcees.ac.cn.
authors: Xing-Hong
authors: XH
authors: Li
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China.
authors: Lianlian
authors: L
authors: Yu
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, China; Beijing Technology and Business University, Beijing 100037, China.
authors: Yun
authors: Y
authors: Zhang
authors: Beijing Technology and Business University, Beijing 100037, China.
authors: Yuan
authors: Y
authors: Tian
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D002681:China; D059029:Electronic Waste; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood / Q000378:metabolism*; D006801:Humans; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D059027:Recycling; D013963:Thyroid Hormones
chemical_list: D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls
keywords: Adipose/serum ratio; E-waste; PCBs and PBDEs; THs