title: Polymorphisms in the gene encoding estrogen receptor alpha are associated with osteoarthritis in Han Chinese women.
abstract: Polymorphisms in the Xba I and Pvu II restriction enzyme recognition sites in the estrogen receptor-alpha gene (ESR1) have been associated with multiple diseases, including osteoarthritis. To determine whether such polymorphisms are associated with osteoarthritis in a Han Chinese population, 98 women with osteoarthritis and 196 healthy women were genotyped by PCR-RFLP of ESR1 with Xba I and Pvu II. Absence of a restriction polymorphism is indicated as an X or P allele; presence of the restriction polymorphism is indicated as an x or p allele. Clinical information was collected on each participant, including body weight, body mass index (BMI), knee radiograms, and bone mineral density (BMD). Body weight and BMI were higher for each Xba I genotype (all P < 0.05) in individuals with osteoarthritis compared to controls (p < 0.05). Femoral BMD was also significantly higher in the osteoarthritis group (p < 0.05). Additionally, the xx genotype for ESR1 was a significant risk factor for osteoarthritis (OR=1.98, 95% CI: 1.13~4.20, p=0.036). Thus, consistent with findings in other populations, the estrogen receptor genotype xx appears to be associated with susceptibility to osteoarthritis among Han Chinese women.
authors: Department of Rheumatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University Zhengzhou 450003, Henan Province, P. R. China.
authors: Wei
authors: W
authors: Liu
authors: Department of Rheumatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University Zhengzhou 450003, Henan Province, P. R. China.
authors: Feng-Min
authors: FM
authors: Shao
authors: Department of Rheumatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University Zhengzhou 450003, Henan Province, P. R. China.
authors: Lei
authors: L
authors: Yan
authors: Department of Rheumatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University Zhengzhou 450003, Henan Province, P. R. China.
authors: Hui-Xia
authors: HX
authors: Cao
authors: Department of Clinical Laboratory, Henan Medical College Zhengzhou 451191, Henan Province, P. R. China.
authors: Dong
authors: D
authors: Qiu
keywords: Osteoarthritis; Pvu II; Xba I; estrogen; estrogen receptor