title: Diazenyl derivatives as therapeutic and diagnostic agents acting on central nervous system.
abstract: In last decade, the development of new drugs and drug products for central nervous system (CNS) has remained limited due to incomplete elucidation of pathophysiology of many CNS disorders, complexity of the diseases and the lack of technologies for delivery through the blood-brain barrier (BBB). In this article we will summarize the development of diazenyl derivatives of many biologically active moieties like benzodiazepine, formazan, indole, pyrimidine, thiazole, sulfonamide etc. as diagnostic and therapeutic agents for CNS. The potential of already existing azo compounds as potent CNS agents have also been discussed. This overview will provide the researchers an opportunity for further development of new diazenyl derivatives in CNS area.
authors: Harmeet
authors: H
authors: Kaur
authors: Snehlata
authors: S
authors: Yadav
authors: Department of Pharmaceutical Sciences, M.D. University Rohtak, Haryana 124001, India. bawideepi@yahoo.co.in.
authors: Balasubramanian
authors: B
authors: Narasimhan
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000188:drug therapy
chemical_list: D002491:Central Nervous System Agents; D007094:Imides; C038867:diazene