title: [NADPH oxidases, Nox: new isoenzymes family].
abstract: NADPH oxidases, Nox, are a family of isoenzymes, composed of seven members, whose sole function is to produce reactive oxygen species (ROS). Although Nox catalyze the same enzymatic reaction, they acquired from a common ancestor during evolution, specificities related to their tissue expression, subcellular localization, activation mechanisms and regulation. Their functions could vary depending on the pathophysiological state of the tissues. Indeed, ROS are not only bactericidal weapons in phagocytes but also essential cellular signaling molecules and their overproduction is involved in chronic diseases and diseases of aging. The understanding of the mechanisms involved in the function of Nox and the emergence of Nox inhibitors, require a thorough knowledge of their nature and structure. The objectives of this review are to highlight, in a structure/function approach, the main similar and differentiated properties shared by the human Nox isoenzymes.
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France.
authors: Minh Vu
authors: MV
authors: Chuong Nguyen
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France - DBTP (département de biochimie, toxicologie et pharmacologie), institut de biologie et pathologie, CHU de Grenoble, France.
authors: Bernard
authors: B
authors: Lardy
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France - DBTP (département de biochimie, toxicologie et pharmacologie), institut de biologie et pathologie, CHU de Grenoble, France.
authors: Marie-Hélène
authors: MH
authors: Paclet
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France.
authors: Francis
authors: F
authors: Rousset
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France.
authors: Sylvie
authors: S
authors: Berthier
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France - Clinique universitaire de rhumatologie, Hôpital Sud, CHU de Grenoble, France.
authors: Athan
authors: A
authors: Baillet
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France - Clinique universitaire de rhumatologie, Hôpital Sud, CHU de Grenoble, France.
authors: Laurent
authors: L
authors: Grange
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France - Clinique universitaire de rhumatologie, Hôpital Sud, CHU de Grenoble, France.
authors: Philippe
authors: P
authors: Gaudin
authors: GREPI (groupe de recherche et d'étude du processus inflammatoire), université Joseph Fourier, Grenoble, France EFS Rhône-Alpes, 29, avenue des Maquis du Grésivaudan, 38700 La Tronche, France.
authors: Françoise
authors: F
authors: Morel
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000639:trends; D005810:Multigene Family; D019255:NADPH Oxidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D007527:Isoenzymes; D019255:NADPH Oxidases