title: Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention.
abstract: BACKGROUND
  Mean platelet volume (MPV) is related to the reactivity of platelets. Among survivors of acute myocardial infarction (MI), greater MPV is known to be associated with impaired reperfusion and higher mortality. The aims of the study is to investigate the dynamic changes of MPV and the relation between MPV and cardiac function in patients with acute MI and received primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  This retrospective cohort study included patients presented during January 2008 to March 2011 to Peking University Third Hospital with ST-segment elevation MI. All patients received successful PCI. MPV was measured serially, using a Sysmex XE2100 haematology analyser, from admission to day-7 after MI.
  
  
  RESULTS
  In 375 patients, MPV was at its highest value (10.2±1.0 fL) and correlated well with platelet distribution width (PDW, r=0.833, p<0.0001) at the admission, and then reduced by 16% within the 24 hours, together with marked weakening of its correlation with PDW. Patients with poorer ventricular function, estimated by high Killip Class (≥2, n=96), had higher MPV values at all-time points. By logistic regression model and after adjusting for related confounders, high MPV remained as an independent predictor of Killip Class ≥2 (OR 1.873, CI 95% 1.373-2.673, p=0.001). Clopidogrel pre-usage resulted in significant MPV reduction on admission.
  
  
  CONCLUSIONS
  MPV undergoes rapid and dynamic changes during the acute phase of MI, and was higher in patients with high Killip Class, suggesting a predictive value of MPV in ventricular dysfunction and clinical outcome of acute phase of MI.
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: Xin-Yu
authors: XY
authors: Wang
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: Hai-Yi
authors: HY
authors: Yu
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: You-Yi
authors: YY
authors: Zhang
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: Yu-Peng
authors: YP
authors: Wang
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: Xin-Heng
authors: XH
authors: Feng
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
authors: Zhao-Ping
authors: ZP
authors: Li
authors: Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Central Clinical School, Monash University, Melbourne, Australia. Electronic address: xiao-jun.du@bakeridi.edu.au.
authors: Xiao-Jun
authors: XJ
authors: Du
authors: Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Science, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. Electronic address: dr_gaowei@medmail.com.cn.
authors: Wei
authors: W
authors: Gao
mesh_terms: D000208:Acute Disease; D000077144:Clopidogrel; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000295:instrumentation* / Q000379:methods; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000379:methods* / Q000401:mortality; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011379:Prognosis; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Acute myocardial infarction; Clopidogrel; Killip Class; Mean platelet volume; Primary percutaneous coronary intervention