title: The epileptic thalamocortical network is a macroscopic self-sustained oscillator: evidence from frequency-locking experiments in rat brains.
abstract: The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.
authors: Neuroscience &Mental Health Programme and Division of Neurology, Hospital for Sick Children; Institute of Medical Science and Department of Paediatrics, University of Toronto, Toronto, Canada.
authors: J L Perez
authors: JL
authors: Velazquez
authors: INSERM-CEA Cognitive Neuroimaging Unit - Point Courrier 156F-91191 Gif SUR YVETTE Cedex, France.
authors: R Guevara
authors: RG
authors: Erra
authors: Department of Physics and Astronomy, University of Potsdam, Potsdam, Germany.
authors: M
authors: M
authors: Rosenblum
mesh_terms: D000818:Animals; D001683:Biological Clocks; D001921:Brain / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials; D009434:Neural Pathways; D051381:Rats; D013788:Thalamus / Q000503:physiopathology*