title: Outcome after resuscitation beyond 30 minutes in drowned children with cardiac arrest and hypothermia: Dutch nationwide retrospective cohort study.
abstract: OBJECTIVE
  To evaluate the outcome of drowned children with cardiac arrest and hypothermia, and to determine distinct criteria for termination of cardiopulmonary resuscitation in drowned children with hypothermia and absence of spontaneous circulation.
  
  
  METHODS
  Nationwide retrospective cohort study.
  
  
  METHODS
  Emergency departments and paediatric intensive care units of the eight university medical centres in the Netherlands.
  
  
  METHODS
  Children aged up to 16 with cardiac arrest and hypothermia after drowning, who presented at emergency departments and/or were admitted to intensive care.
  
  
  METHODS
  Survival and neurological outcome one year after the drowning incident. Poor outcome was defined as death or survival in a vegetative state or with severe neurological disability (paediatric cerebral performance category (PCPC) ≥ 4).
  
  
  RESULTS
  From 1993 to 2012, 160 children presented with cardiac arrest and hypothermia after drowning. In 98 (61%) of these children resuscitation was performed for more than 30 minutes (98/160, median duration 60 minutes), of whom 87 (89%) died (95% confidence interval 83% to 95%; 87/98). Eleven of the 98 children survived (11%, 5% to 17%), but all had a PCPC score ≥ 4. In the 62 (39%) children who did not require prolonged resuscitation, 17 (27%, 16% to 38%) survived with a PCPC score ≤ 3 after one year: 10 (6%) had a good neurological outcome (score 1), five (3%) had mild neurological disability (score 2), and two (1%) had moderate neurological disability (score 3). From the original 160 children, only 44 were alive at one year with any outcome.
  
  
  CONCLUSIONS
  Drowned children in whom return of spontaneous circulation is not achieved within 30 minutes of advanced life support have an extremely poor outcome. Good neurological outcome is more likely when spontaneous circulation returns within 30 minutes of advanced life support, especially when the drowning incident occurs in winter. These findings question the therapeutic value of resuscitation beyond 30 minutes in drowned children with cardiac arrest and hypothermia.
authors: Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Netherlands j.k.w.kieboom@umcg.nl.
authors: J K
authors: JK
authors: Kieboom
authors: Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Netherlands.
authors: H J
authors: HJ
authors: Verkade
authors: Department of Epidemiology University Medical Centre Groningen, University of Groningen, Netherlands.
authors: J G
authors: JG
authors: Burgerhof
authors: Van Heurnlaan 10-Anaesthesiology, Vught, Netherlands.
authors: J J
authors: JJ
authors: Bierens
authors: Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Netherlands.
authors: P F van
authors: PF
authors: Rheenen
authors: Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Netherlands.
authors: M C
authors: MC
authors: Kneyber
authors: Department of Paediatrics, St Elizabeth's Hospital, Tilburg, Netherlands.
authors: M J
authors: MJ
authors: Albers
mesh_terms: D000293:Adolescent; D016887:Cardiopulmonary Resuscitation; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004332:Drowning; D005260:Female; D006323:Heart Arrest / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007035:Hypothermia / Q000209:etiology / Q000628:therapy*; D007223:Infant; D008297:Male; D015701:Near Drowning / Q000628:therapy*; D009426:Netherlands; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D028761:Withholding Treatment