title: Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters.
abstract: This experiment was aimed at elucidating the protective effect of resveratrol against diabetes. Forty male Wistar albino rats were allocated into four groups: the control and streptozotocin (STZ)-induced diabetes groups were treated either with placebo (1 ml/kg, i.p.) or resveratrol (20 mg/kg, i.p.) for 8 weeks. Body weight, blood glucose and serum malondialdehyde (MDA) concentrations were monitored. At the end of the experimental period, expression levels of visfatin, sirtuin-1 (SIRT1) and glucose transporters (GLUTs, 2 and 4) were measured in skeletal muscle and pancreas by Western blotting. The resveratrol treatment partially compensated for body weight loss and alleviated hyperglycaemia and returned serum MDA concentrations to the control group levels. Data suggest that supplementation may reduce the severity of diabetes and its complications through suppressing oxidative stress and increasing potential to internalise glucose by extrahepatic tissues.
authors: Department of Biology, Faculty of Science, Firat University , Elazig , Turkey .
authors: Hasan
authors: H
authors: Gencoglu
authors: Mehmet
authors: M
authors: Tuzcu
authors: Armagan
authors: A
authors: Hayirli
authors: Kazim
authors: K
authors: Sahin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism*; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018482:Muscle, Skeletal / Q000378:metabolism; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D015431:Weight Loss
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D051246:Glucose Transport Proteins, Facilitative; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D059808:Polyphenols; D013267:Stilbenes; D008315:Malondialdehyde; D054409:Nicotinamide Phosphoribosyltransferase; D056564:Sirtuin 1; D000077185:Resveratrol
keywords: Oxidative stress; polyphenols; preventive medicine; systemic diseases