title: Organelle targeting during bacterial infection: insights from Listeria.
abstract: Listeria monocytogenes, a facultative intracellular bacterium responsible for severe foodborne infections, is now recognized as a multifaceted model in infection biology. Comprehensive studies of the molecular and cellular basis of the infection have unraveled how the bacterium crosses the intestinal and feto-placental barriers, invades several cell types in which it multiplies and moves, and spreads from cell to cell. Interestingly, although Listeria does not actively invade host cell organelles, it can interfere with their function. We discuss the effect of Listeria on the endoplasmic reticulum (ER) and the mechanisms leading to the fragmentation of the mitochondrial network and its consequences, and review the strategies used by Listeria to subvert nuclear functions, more precisely to control host gene expression at the chromatin level.
authors: Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 604, 75015 Paris, France; Institut National de la Recherche Agronomique (INRA), Unité USC2020, 75015 Paris, France.
authors: Alice
authors: A
authors: Lebreton
authors: Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 604, 75015 Paris, France; Institut National de la Recherche Agronomique (INRA), Unité USC2020, 75015 Paris, France.
authors: Fabrizia
authors: F
authors: Stavru
authors: Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 604, 75015 Paris, France; Institut National de la Recherche Agronomique (INRA), Unité USC2020, 75015 Paris, France. Electronic address: pascale.cossart@pasteur.fr.
authors: Pascale
authors: P
authors: Cossart
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism* / Q000382:microbiology*; D001426:Bacterial Proteins / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008087:Listeria / Q000302:isolation & purification*; D008089:Listeria monocytogenes / Q000302:isolation & purification*; D008928:Mitochondria / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins
keywords: Listeria monocytogenes; cellular microbiology; endomembrane system; mitochondria; nucleus; organelle