title: d-Amino acids do not inhibit biofilm formation in Staphylococcus aureus.
abstract: Bacteria can either exist in the planktonic (free floating) state or in the biofilm (encased within an organic framework) state. Bacteria biofilms cause industrial concerns and medical complications and there has been a great deal of interest in the discovery of small molecule agents that can inhibit the formation of biofilms or disperse existing structures. Herein we show that, contrary to previously published reports, d-amino acids do not inhibit biofilm formation of Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), and Staphylococcus epidermis (S. epidermis) at millimolar concentrations. We evaluated a diverse set of natural and unnatural d-amino acids and observed no activity from these compounds in inhibiting biofilm formation.
authors: Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania, United States of America.
authors: Sourav
authors: S
authors: Sarkar
authors: Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania, United States of America.
authors: Marcos M
authors: MM
authors: Pires
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000502:physiology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D015394:Molecular Structure; D010649:Phenylalanine / Q000737:chemistry / Q000494:pharmacology; D011392:Proline / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000502:physiology; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry / Q000494:pharmacology; D014443:Tyrosine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D011392:Proline