title: Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers.
abstract: Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and fluorescence spectroscopy, showing no binding with β-cyclodextrin but high binding with β-cyclodextrin polymers. In aqueous solution nanoparticles were formed from association between the (S)-camptothecin-dextran polymers and the β-cyclodextrin polymers.
authors: Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors: Thorbjørn Terndrup
authors: TT
authors: Nielsen
authors: Systèmes Polymères Complexes, ICMPE, CNRS and University Paris Est, 2 rue Henri Dunant, 94320 Thiais, France.
authors: Catherine
authors: C
authors: Amiel
authors: Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors: Laurent
authors: L
authors: Duroux
authors: Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors: Kim Lambertsen
authors: KL
authors: Larsen
authors: Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors: Lars Wagner
authors: LW
authors: Städe
authors: Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark.
authors: Reinhard
authors: R
authors: Wimmer
authors: Systèmes Polymères Complexes, ICMPE, CNRS and University Paris Est, 2 rue Henri Dunant, 94320 Thiais, France.
authors: Véronique
authors: V
authors: Wintgens
keywords: (S)-camptothecin; ITC; cyclodextrins; fluorescence; nanoparticles