title: M235T polymorphism in the AGT gene and A/G(I8-83) substitution in the REN gene correlate with end-stage renal disease.
abstract: OBJECTIVE
  This study aimed at investigating if M235T polymorphism in the AGT gene and A/G(I8-83) polymorphism in the REN gene correlate with end-stage renal disease (ESRD).
  
  
  METHODS
  We analyzed 173 ESRD patients and 329 individuals with normal kidney function for differences in the genotype distribution of AGT-M235T and REN-A/G(I8-83) polymorphisms between the two groups. The data for cases and controls were compared using the χ(2) test.
  
  
  RESULTS
  We found significantly higher levels of serum creatinine and CRP in cases in comparison to controls (p < 0.0001). Data comparison showed a significant association of AGT M235T substitution with ESRD in the dominant model (p = 0.008) and in the comparison of the heterozygous substitution with the homozygous common genotype (p = 0.005). Similarly, REN A/G(I8-83) polymorphism showed a significant difference in the distribution of genotypes between cases and controls (p < 0.038) such that a heterozygous substitution was significantly more common in the ESRD cases in comparison to the homozygous common genotype (p = 0.023).
  
  
  CONCLUSIONS
  We conclude that heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci correlate significantly with ESRD in a north Indian population.
authors: Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
authors: Saumya
authors: S
authors: Sarkar
authors: Vikas
authors: V
authors: Gupta
authors: Ajay
authors: A
authors: Kumar
authors: Manoj
authors: M
authors: Chaudhary
authors: Subhash
authors: S
authors: Diyundi
authors: Prabodh K
authors: PK
authors: Sehajpal
authors: Kumarasamy
authors: K
authors: Thangaraj
authors: Singh
authors: S
authors: Rajender
mesh_terms: D019943:Amino Acid Substitution; D000808:Angiotensinogen / Q000235:genetics*; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D005787:Gene Frequency; D011905:Genes, ras / Q000235:genetics; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012083:Renin / Q000235:genetics*
chemical_list: D000808:Angiotensinogen; D004247:DNA; D012083:Renin