title: Elevated fecal calprotectin in patients with Alzheimer's dementia indicates leaky gut.
abstract: Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer's disease (AD) and compared with serum concentrations of aromatic amino acids. Calprotectin concentrations were mean ± SEM 140 ± 31.9 mg/kg, 16 patients (73%) presented with concentrations outside normal (>50 mg/kg). Concentrations correlated inversely with serum levels of tryptophan, tyrosine and phenylalanine (all p < 0.05). Increased concentrations of fecal calprotectin indicate a disturbed intestinal barrier function in AD patients which could be of relevance for the lowering of essential aromatic amino acids concentrations in the blood.
authors: Department of Gerontology, Landesnervenklinik Wagner-Jauregg Linz, Wagner-Jauregg Weg 15, 4020, Linz, Austria.
authors: Friedrich
authors: F
authors: Leblhuber
authors: Simon
authors: S
authors: Geisler
authors: Kostja
authors: K
authors: Steiner
authors: Dietmar
authors: D
authors: Fuchs
authors: Burkhard
authors: B
authors: Schütz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D010649:Phenylalanine / Q000097:blood; D014364:Tryptophan / Q000097:blood; D014443:Tyrosine / Q000097:blood
chemical_list: D039841:Leukocyte L1 Antigen Complex; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan