title: Rare case of a primary intracranial chondrosarcoma.
abstract: BACKGROUND
  Intracranial chondrosarcomas comprise 6% of all skull base neoplasms and account for 0.15% of all intracranial tumors. They are potentially fatal, invading the brain and elevating intracranial pressure by progressive enlargement. Diplopia and headache are the most common clinical symptoms. Previous data indicate a particularly aggressive behavior of intracranial chondrosarcomas.
  
  
  METHODS
  A 17-year-old female patient presented to the hospital with focal seizures. A magnetic resonance imaging (MRI) scan revealed a brain tumor located in the right meso-temporal region. Total tumor resection, followed by conformal proton therapy was performed. The tumor displayed a chondroid differentiation, and accordingly, a chondrosarcoma was diagnosed. At follow-up investigation two years after the resection of the tumor, the patient was in a good general state of health and no tumor recurrence had occurred.
  
  
  CONCLUSIONS
  Intracranial chondrosarcoma is a differential diagnosis for intracranial tumors of the skull base. State-of-the-art therapy should comprise of surgical resection and adjuvant radiotherapy. Previously published data about intracranial chondrosarcomas indicate the extreme aggressiveness of this tumor entity.
authors: Department of Neuropathology, Institute of Pathology, Medical University Graz, Graz, Austria.
authors: Elisabeth
authors: E
authors: Smolle
authors: University Clinic of Neurosugery, Medical University Graz, Graz, Austria.
authors: Michael
authors: M
authors: Mokry
authors: Department of Neuropathology, Institute of Pathology, Medical University Graz, Graz, Austria johannes.haybaeck@medunigraz.at.
authors: Johannes
authors: J
authors: Haybaeck
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D002813:Chondrosarcoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D055815:Young Adult
keywords: Chondrosarcoma; intracranial tumour; prognosis