title: Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population.
abstract: BACKGROUND
  Defensins are antimicrobial peptides expressed on mucosal surfaces. They function as part of the innate immune system. Palatine tonsils play important roles in innate immune system. However, our knowledge on the pathophysiology of chronic tonsils is limited.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association between beta defensin 1 gene single nucleotide polymorphisms and chronic tonsillitis.
  
  
  METHODS
  Prospective, non-randomized, controlled clinical study.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Eighty six patients with chronic tonsillitis and eighty controls without history of chronic tonsillitis were enrolled in this study. Genotypes were determined by restriction fragment length polymorphism analyses after polymerase chain reaction.
  
  
  RESULTS
  Genotype and allele frequencies of the -20G/A (rs11362), -44C/G (rs1800972) and -52G/A (rs1799946) single nucleotide polymorphisms were not statistically different between patients and control groups (p>0.05).
  
  
  CONCLUSIONS
  In this study, we found that DEFB1 gene -20G/A, -44C/G and -52G/A single nucleotide polymorphisms were not associated with chronic tonsillitis. Studies, which analyse other polymorphism of the beta defensin 1 gene in large case series, should be conducted to understand the role of DEFB1 gene on chronic tonsillitis.
authors: Department of Otolaryngology, Baskent University, Faculty of Medicine, M. Fevzi Cakmak Caddesi, 5. Sokak, No: 48, 06490 Ankara, Turkey. Electronic address: drfatihkbb@gmail.com.
authors: Fatih
authors: F
authors: Arslan
authors: Department of Otolaryngology, Baskent University, Faculty of Medicine, M. Fevzi Cakmak Caddesi, 5. Sokak, No: 48, 06490 Ankara, Turkey. Electronic address: selimerbek@gmail.com.
authors: Seda Turkoglu
authors: ST
authors: Babakurban
authors: Department of Otolaryngology, Baskent University, Faculty of Medicine, M. Fevzi Cakmak Caddesi, 5. Sokak, No: 48, 06490 Ankara, Turkey.
authors: Selim S
authors: SS
authors: Erbek
authors: Department of Medical Genetics, Baskent University, Faculty of Medicine, Kubilay Sokak, No: 36 Maltepe, 06570 Ankara, Turkey. Electronic address: feridesahin@hotmail.com.
authors: Feride I
authors: FI
authors: Sahin
authors: Department of Medical Genetics, Baskent University, Faculty of Medicine, Kubilay Sokak, No: 36 Maltepe, 06570 Ankara, Turkey. Electronic address: ykterzi@gmail.com.
authors: Yunus Kasım
authors: YK
authors: Terzi
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D014069:Tonsillitis / Q000235:genetics*; D014421:Turkey; D055815:Young Adult; D023083:beta-Defensins / Q000235:genetics*
chemical_list: C406407:DEFB1 protein, human; D023083:beta-Defensins
keywords: Chronic tonsillitis; DEFB1 gene; Genotype; Polymorphism