title: A newly developed lubricant, chitosan laurate, in the manufacture of acetaminophen tablets.
abstract: To study the usefulness of chitosan laurate (CS-LA), a newly developed chitosan salt, as a lubricant, lubrication properties such as the pressure transmission ratio and ejection force were determined at different concentrations of CS-LA in tableting. In addition, tablet properties such as the tensile strength, disintegration time, and dissolution behavior, were also determined. When CS-LA was mixed at concentrations of 0.1%-3.0%, the pressure transmission ratio was increased in a concentration-dependent manner, and the value at a CS-LA concentration of 3% was equal to that of magnesium stearate (Mg-St), a widely used lubricant. Additionally, a reduction in the ejection force was observed at a concentration from 1%, proving that CS-LA has good lubrication performance. A prolonged disintegration time and decreased tensile strength, which are known disadvantages of Mg-St, were not observed with CS-LA. Furthermore, with CS-LA, retardation of dissolution of the drug from the tablets was not observed. Conjugation of CS with LA was found to be quite important for both lubricant and tablet properties. In conclusion, CS-LA should be useful as an alternative lubricant to Mg-St.
authors: Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
authors: Ahmad
authors: A
authors: Bani-Jaber
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors: Asuka
authors: A
authors: Kobayashi
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors: Kyohei
authors: K
authors: Yamada
authors: Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
authors: Dana
authors: D
authors: Haj-Ali
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors: Takeaki
authors: T
authors: Uchimoto
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: yasuiwao@u-shizuoka-ken.ac.jp.
authors: Yasunori
authors: Y
authors: Iwao
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors: Shuji
authors: S
authors: Noguchi
authors: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors: Shigeru
authors: S
authors: Itai
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry*; D054327:Lubricants / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry
chemical_list: D054327:Lubricants; D013607:Tablets; D000082:Acetaminophen; D048271:Chitosan
keywords: Chitosan laurate; Lubricant properties; Magnesium stearate; Tablet characteristics; Tableting