title: A signal-to-cutoff ratio in the Abbott architect HIV Ag/Ab Combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting.
abstract: A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.
authors: Department of Infectious Diseases and The Albion Centre, Prince of Wales Hospital, Sydney, Australia Prince of Wales Clinical School, University of New South Wales, Sydney, Australia doctomas@gmail.com.
authors: Tomas Ostergaard
authors: TO
authors: Jensen
authors: Serology and Virology Division, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia.
authors: Peter
authors: P
authors: Robertson
authors: Serology and Virology Division, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia.
authors: Ross
authors: R
authors: Whybin
authors: Douglass Hanly Moir Pathology, Sydney, Australia.
authors: Ian
authors: I
authors: Chambers
authors: Serology and Virology Division, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia.
authors: Monica
authors: M
authors: Lahra
authors: Serology and Virology Division, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia.
authors: William
authors: W
authors: Rawlinson
authors: Department of Infectious Diseases and The Albion Centre, Prince of Wales Hospital, Sydney, Australia Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
authors: Jeffrey John
authors: JJ
authors: Post
mesh_terms: D000328:Adult; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015488:HIV Antigens / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods*
chemical_list: D015483:HIV Antibodies; D015488:HIV Antigens