title: Association between coeliac disease and psoriasis: Italian primary care multicentre study.
abstract: BACKGROUND
  Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results.
  
  
  OBJECTIVE
  To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD.
  
  
  METHODS
  We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically.
  
  
  RESULTS
  Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis.
  
  
  CONCLUSIONS
  Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.
authors: GIGA-CP (Italian Group for Primary Care Gastroenterology), Milan, Italy.
authors: Rudi
authors: R
authors: De Bastiani
authors: Maurizio
authors: M
authors: Gabrielli
authors: Liliana
authors: L
authors: Lora
authors: Luigi
authors: L
authors: Napoli
authors: Cesare
authors: C
authors: Tosetti
authors: Enzo
authors: E
authors: Pirrotta
authors: Enzo
authors: E
authors: Ubaldi
authors: Luciano
authors: L
authors: Bertolusso
authors: Maria
authors: M
authors: Zamparella
authors: Manuela
authors: M
authors: De Polo
authors: Cristina
authors: C
authors: Nebiacolombo
authors: Mario
authors: M
authors: Bortot
authors: Maurizio
authors: M
authors: Mancuso
authors: Paolo
authors: P
authors: Bacchin
authors: Valerio
authors: V
authors: Marsala
authors: Roberto
authors: R
authors: Pinna
authors: Antonio
authors: A
authors: Tursi
authors: Edoardo
authors: E
authors: Benedetto
authors: Alfredo
authors: A
authors: Cuffari
authors: Antonino
authors: A
authors: Pati
authors: Simona
authors: S
authors: Di Caro
authors: Gastone
authors: G
authors: Perenzin
authors: Raffaella
authors: R
authors: Sala
authors: Giacomo
authors: G
authors: Calzavara Pinton
authors: Antonio
authors: A
authors: Gasbarrini
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy* / Q000453:epidemiology*; D055050:Diet, Gluten-Free; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011565:Psoriasis / Q000097:blood / Q000178:diet therapy* / Q000453:epidemiology; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins