title: Tissue-engineered urinary conduits.
abstract: The role of tissue engineering in the cystectomy population rests on the principle of sparing healthy intestinal tissue while replacing diseased bladder. Over the last 25 years advances in cell biology and material science have improved the quality and durability of bladder replacement in animals. The neo-urinary conduit ([NUC]-Tengion) employs autologous fat smooth muscle cells which are seeded onto synthetic, biodegradable scaffolds. This seeded construct is then implanted in the patient and purportedly regenerates native urinary tissue to serve as a passive channel connecting the ureters to the skin surface. Preclinical animal studies as well as the first phase I human trial implanting the NUC are reviewed. While the ultimate goal of creating a durable, effective, tissue-engineered conduit is still in its infancy, important technical and experimental strides have been made.
authors: James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, 1800 Orleans Street, Marburg 134, Baltimore, MD, 21287, USA, mkates@jhmi.edu.
authors: Max
authors: M
authors: Kates
authors: Anirudha
authors: A
authors: Singh
authors: Hotaka
authors: H
authors: Matsui
authors: Gary D
authors: GD
authors: Steinberg
authors: Norm D
authors: ND
authors: Smith
authors: Mark P
authors: MP
authors: Schoenberg
authors: Trinity J
authors: TJ
authors: Bivalacqua
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D015653:Cystectomy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D009940:Organoids / Q000098:blood supply / Q000502:physiology; D012038:Regeneration; D013234:Stem Cells; D023822:Tissue Engineering; D001743:Urinary Bladder / Q000502:physiology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins