title: Papillary thyroid carcinoma with nodular fasciitis-like stroma: a usual entity with distinctive morphology.
abstract: Papillary thyroid carcinoma (PTC) is a common malignancy with multiple variants, some of which are rarely encountered in routine surgical pathology practice. PTC with exuberant nodular fasciitis-like stroma (PTC-NFS) or PTC with fibromatosis-like stroma (PTC-FMS) is one such variant. We report a case of PTC-NFS, a tumor characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of conventional PTC. We review the literature on this rare variant, discuss the importance of a thorough search for epithelial components within any fibroproliferative lesion of the thyroid, and address the diagnostic difficulties created by the tumor's extensive stromal component.
authors: Weill Cornell Medical College, New York, NY, USA psg9003@nyp.org.
authors: Paula S
authors: PS
authors: Ginter
authors: Weill Cornell Medical College, New York, NY, USA.
authors: Theresa
authors: T
authors: Scognamiglio
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary; D005208:Fasciitis / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017154:Stromal Cells / Q000473:pathology; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: fibromatosis-like stroma; nodular fasciitis-like stroma; papillary thyroid carcinoma