title: Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): Clinical and biological features and comparison with other acute myeloid leukemias with cytogenetic aberrations involving long arm of chromosome 3.
abstract: OBJECTIVE
  To compare, from a biological and clinical perspective, a significant group of patients with AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) with another group of AML carrying different abnormalities of 3q at q21 or q26, the latter named as the AML abn(3q) group.
  
  
  METHODS
  We developed a national survey with the participation of 13 Spanish hospitals, and retrospectively reviewed (from 1990 to 2010) these subtypes of AML. Fifty-five patients were collected: 35 with AML inv(3)/t(3;3) and 20 with AML abn(3q). A data collecting page that included main features at diagnosis, therapeutic approach and response, and survival variables, was distributed and completed.
  
  
  RESULTS
  We did not find significant differences in sex, age, history of myelodysplastic syndrome or chemo-/radiotherapy, clinical presentation, WBC and platelet counts, hemoglobin level, blasts immunophenotype, serum lactatedehydrogenase, peripheral blood and bone marrow cellular dysplasia, and bone marrow biopsy findings. Although the association with monosomy 7 was significantly more frequent in AML inv(3)/t(3;3), this did not seem to influence outcome. The lack of response to the different modalities of treatment and the aggressive course of the disease were the standard in both cohorts of patients.
  
  
  CONCLUSIONS
  Although not yet recognized by the World Health Organization classification, our results are in agreement with the findings of other authors, who include both subsets of AML together in the same group of adverse prognosis.
  
  
  CONCLUSIONS
  In an attempt to simplify and bound entities with similar genetic background and clinical behavior, it would be desirable to bring together both subgroups of AML in a single section.
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Jose Maria
authors: JM
authors: Raya
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Taida
authors: T
authors: Martín-Santos
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Elisa
authors: E
authors: Luño
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Carmen
authors: C
authors: Sanzo
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Maria Luz
authors: ML
authors: Perez-Sirvent
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Esperanza
authors: E
authors: Such
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: José Tomás
authors: JT
authors: Navarro
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Fuensanta
authors: F
authors: Millá
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Esther
authors: E
authors: Alonso
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Alicia
authors: A
authors: Domingo
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: María
authors: M
authors: Rozman
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Marina
authors: M
authors: Díaz-Beva
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Ana
authors: A
authors: Batlle
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Sonia
authors: S
authors: González-de-Villambrosia
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Esperanza
authors: E
authors: Tuset
authors: a Department of Hematology Hospital Universitario de Canarias , Ofra s/n, 38320 La Laguna, Spain.
authors: Teresa
authors: T
authors: Vallespí
authors: Margarita
authors: M
authors: Ortega
authors: Alfredo
authors: A
authors: Bermejo
authors: Marisa
authors: M
authors: Martín-Ramos
authors: Valeria
authors: V
authors: Peri
authors: Francesc
authors: F
authors: Solé
authors: Lourdes
authors: L
authors: Florensa
keywords: Acute myeloid leukemia; Acute myeloid leukemia with abnormalities at 3q; Acute myeloid leukemia with inv(3)/t(3; 3); Long arm of chromosome 3.; The 3q21q26 syndrome