title: Factors influencing culture positivity in pyogenic vertebral osteomyelitis patients with prior antibiotic exposure.
abstract: We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Chung-Jong
authors: CJ
authors: Kim
authors: Department of Infectious Diseases, Chonnam National University Medical School, Gwang-ju, Republic of Korea.
authors: Seung-Ji
authors: SJ
authors: Kang
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Doran
authors: D
authors: Yoon
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Myung Jin
authors: MJ
authors: Lee
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Moonsuk
authors: M
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Kyoung-Ho
authors: KH
authors: Song
authors: Department of Infectious Diseases, Chonnam National University Medical School, Gwang-ju, Republic of Korea.
authors: Hee-Chang
authors: HC
authors: Jang
authors: Department of Infectious Diseases, Chonnam National University Medical School, Gwang-ju, Republic of Korea.
authors: Sook-In
authors: SI
authors: Jung
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Eu Suk
authors: ES
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Hong Bin
authors: HB
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Myoung-Don
authors: MD
authors: Oh
authors: Department of Infectious Diseases, Chonnam National University Medical School, Gwang-ju, Republic of Korea molder@unitel.co.kr iammedkid@naver.com.
authors: Kyung-Hwa
authors: KH
authors: Park
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea molder@unitel.co.kr iammedkid@naver.com.
authors: Nam Joong
authors: NJ
authors: Kim
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy; D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D005334:Fever / Q000150:complications; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000382:microbiology*; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000382:microbiology*; D013131:Spine / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein