title: Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study.
abstract: The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles. Cases (n = 485) and controls (n = 485) were extensively matched in a one-to-one ratio on nine physical and clinical parameters: maternal age, body mass index, smoking status, stimulation cycle number, cumulative dose of FSH, stimulation protocol, insemination method, day of embryo transfer and number of embryos transferred. No significant differences were found in fresh cycles between cases and controls for the pregnancy outcomes analysed, but fewer surplus embryos were available for freezing in the combined adjuvant group. In FET cycles, LBR was lower in the treatment group (OR: 0.49, 95% CI 0.25 to 0.95). The lower LBR in FET cycles seemed to be clustered in patients receiving combined adjuvant treatment without luteal oestradiol (OR 0.37, 95% CI 0.17 to 0.80). No difference was found in LBR between cases and controls when stratified according to the number of previous cycles (<3 or ≥3). There is no benefit of this combined adjuvant strategy in fresh IVF cycles, and possible harm when used in frozen cycles.
authors: Monash IVF, 252-256 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia.
authors: C
authors: C
authors: Motteram
authors: Monash IVF, 252-256 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia; Monash University, Department of Obstetrics & Gynaecology, 246 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia; Women's and Children's Programme, Monash Health, 246 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia.
authors: B
authors: B
authors: Vollenhoven
authors: Monash IVF, 252-256 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia.
authors: N
authors: N
authors: Hope
authors: Monash IVF, 252-256 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia; Monash University, Department of Obstetrics & Gynaecology, 246 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia.
authors: T
authors: T
authors: Osianlis
authors: Monash IVF, 252-256 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia; Monash University, Department of Obstetrics & Gynaecology, 246 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia; Women's and Children's Programme, Monash Health, 246 Clayton Rd, Clayton, Melbourne, Vic. 3168, Australia. Electronic address: rombauts@bigpond.net.au.
authors: L J
authors: LJ
authors: Rombauts
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D001723:Birth Rate; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D004318:Doxycycline / Q000627:therapeutic use*; D004624:Embryo Transfer / Q000379:methods; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D004958:Estradiol; D011239:Prednisolone; D004318:Doxycycline; D001241:Aspirin
keywords: antibiotics; aspirin; in-vitro fertilization; intracytoplasmic sperm injection; oestradiol; prednisolone