title: Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy.
abstract: Antiplatelet therapy is the standard of care for the secondary prevention of acute coronary syndrome and ischemic stroke, especially after coronary intervention. However, this therapy is associated with bleeding complications such as gastrointestinal bleeding, which is one of the most common life-threatening complications. Early endoscopy is recommended for most patients with acute upper gastrointestinal bleeding. After successful endoscopic hemostasis, immediate resumption of antiplatelet therapy with proton-pump inhibitors (PPIs) is recommended to prevent further ischemic events. PPI prophylaxis during antiplatelet therapy reduces the risk of upper gastrointestinal bleeding. The potential negative metabolic interaction between PPIs and clopidogrel is still unclear.
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Hiroshi
authors: H
authors: Yasuda
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Yasumasa
authors: Y
authors: Matsuo
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Yoshinori
authors: Y
authors: Sato
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Sun-Ichiro
authors: S
authors: Ozawa
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Shinya
authors: S
authors: Ishigooka
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Masaki
authors: M
authors: Yamashita
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Hiroyuki
authors: H
authors: Yamamoto
authors: Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors: Fumio
authors: F
authors: Itoh
keywords: Antiplatelet therapy; Aspirin; Clopidogrel; Endoscopy; Gastrointestinal bleeding; Proton-pump inhibitor