title: MiR-206, a key modulator of skeletal muscle development and disease.
abstract: MicroRNAs (miRNAs) have recently emerged as fundamental post-transcriptional regulators inhibit gene expression linked to various biological processes. MiR-206 is one of the most studied and best characterized miRNA to date, which specifically expressed in skeletal muscle. In this review, we summarized the results of studies of miR-206 with emphasis on its function in skeletal muscle development. Importantly, dysregulation of miR-206 has been linked to many disorders in skeletal muscle such as Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS), and circulating miR-206 has highlighted its potential as a diagnose biomarker. In addition, a mutation in the 3' untranslated region (3'-UTR) of the myostatin gene in the Texel sheep creating a target site for the miR-206 and miR-1 leads to inhibition of myostatin expression, which likely to cause the muscular hypertrophy phenotype of this breed of sheep. Therefore, miR-206 may become novel target for ameliorating skeletal muscle-related disorders and optimization of muscle quantity of domestic animals.
authors: 1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China; ; 2. Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China;
authors: Guoda
authors: G
authors: Ma
authors: 3. Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
authors: Yajun
authors: Y
authors: Wang
authors: 1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
authors: You
authors: Y
authors: Li
authors: 1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
authors: Lili
authors: L
authors: Cui
authors: 4. Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors: Yujuan
authors: Y
authors: Zhao
authors: 2. Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China;
authors: Bin
authors: B
authors: Zhao
authors: 1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
authors: Keshen
authors: K
authors: Li
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008957:Models, Genetic; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D009135:Muscular Diseases / Q000235:genetics; D012038:Regeneration
chemical_list: C546087:MIRN206 microRNA, human; D035683:MicroRNAs
keywords: development; disease; miR-206; skeletal muscle