title: Using absorbable chitosan hemostatic sponges as a promising surgical dressing.
abstract: As absorbable hemostatic dressings, chitosan with a deacetylation degree of 40% (CS-40) and 73% (CS-73) have been fabricated into sponges via a modified method. The hemostatic, biocompatible and biodegradable properties were evaluated through in vivo assays. In a hepatic hemorrhage model, the chitosan sponges, with excellent blood compatibility, achieved less blood loss than the gelation sponge (GS). In addition, CS-40 showed better hemostatic capability and biodegradability than CS-73. After implantation, a histological analysis indicated that CS-40 exhibited the best biodegradability, tissue regeneration and least tissue adhesion. By contrasting CS-40 and CS-73, the deacetylation degree is confirmed to be a key factor for the hemostatic effect, biodegradability, biocompatibility and tissue regeneration. Our overall results demonstrated the potential application of CS-40 for use in absorbable hemostatic dressings.
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Xiaofei
authors: X
authors: Huang
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Yongfu
authors: Y
authors: Sun
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Jingyi
authors: J
authors: Nie
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Wentao
authors: W
authors: Lu
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors: Ling
authors: L
authors: Yang
authors: College of Life and Environmental Science, Hangzhou Normal University, Hangzhou 310036, China.
authors: Zhiliang
authors: Z
authors: Zhang
authors: Division of Basic Medical Science, Hangzhou Normal University, Hangzhou 310036, China.
authors: Hongping
authors: H
authors: Yin
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: wangzk@zju.edu.cn.
authors: Zhengke
authors: Z
authors: Wang
authors: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: huql@zju.edu.cn.
authors: Qiaoling
authors: Q
authors: Hu
mesh_terms: D000107:Acetylation; D000268:Adhesiveness; D000818:Animals; D001458:Bandages; D001835:Body Weight / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D005781:Gelatin Sponge, Absorbable / Q000494:pharmacology; D006490:Hemostatics / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008422:Materials Testing; D016062:Porosity; D066244:Proton Magnetic Resonance Spectroscopy; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D015503:Surgical Sponges; D014867:Water / Q000737:chemistry
chemical_list: D006490:Hemostatics; D014867:Water; D048271:Chitosan
keywords: Chitosan; Hemostatic sponge; Wound healing