title: M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study.
abstract: Recurrent spontaneous abortion (RSA) is a prevalent condition among the Malay population of Malaysia, where carriage risk of conventional hereditary thrombophilia factors has been generally ruled out. The contribution of M2/ANXA5, a common haplotype in the annexin A5 gene promoter, was evalauted for RSA in Malay. Seventy-seven women who had experienced two or more unexplained RSA and 41 available male partners were selected for study, with 360 population controls recruited from healthy Malay individuals. Incidence of M2 carriage and odds ratios were calculated between control and patient groups, and clinically defined subgroups and RSA risk was evaluated. M2/ANXA5, found in 42.2% of the general Malay population, was associated with greater risks for women with primary and secondary RSA with early (gestational week 5-15) losses. The risk was somewhat higher in Malay couples when both partners were carriers and a trend of higher prevalence was seen for the male partners patients who had experienced RSA. M2 carriage seems to be a risk factor with unusually high incidence in Malay women and couples with primary and secondary RSA with 'early' spontaneous abortions. The associated male partner risk confirms the proposed role of M2/ANXA5 as a genetic trait impeding embryonic anticoagulation.
authors: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia. Electronic address: tangth.amdi@usm.edu.my.
authors: Tang
authors: T
authors: Thean Hock
authors: Institute of Human Genetics, University of Muenster, Muenster, Germany.
authors: Nadja
authors: N
authors: Bogdanova
authors: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
authors: Ang
authors: A
authors: Kai Cheen
authors: Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia.
authors: Sushilnathan
authors: S
authors: Kathirgamanathan
authors: Department of Obstetrics and Gynaecology, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia.
authors: Ridzuan
authors: R
authors: Bin Abdullah
authors: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
authors: Narazah
authors: N
authors: Mohd Yusoff
authors: School of Medical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
authors: Wan
authors: W
authors: Zaidah Abdullah
authors: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
authors: Faizatul
authors: F
authors: Syima Abdul Manaf
authors: Institute of Human Genetics, University of Muenster, Muenster, Germany.
authors: Peter
authors: P
authors: Wieacker
authors: Institute of Human Genetics, University of Muenster, Muenster, Germany. Electronic address: markoff@uni-muenster.de.
authors: Arseni
authors: A
authors: Markoff
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D017304:Annexin A5 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011247:Pregnancy; D015995:Prevalence; D012306:Risk; D055815:Young Adult
chemical_list: D017304:Annexin A5
keywords: ANXA5; M2/ANXA5; annexin A5; recurrent pregnancy loss; risk factor