title: Primary natural killer/T cell lymphoma of the cervix: case report and clinicopathological analysis.
abstract: OBJECTIVE
  To present pathological and molecular characterizations of a rare case that was diagnosed as nasal-type natural killer (NK)/T cell lymphoma primarily arising in the cervix.
  
  
  METHODS
  An Asian woman was admitted to hospital with a hysteromyoma, and laparotomy was performed. A large tumor of the uterus was found, which was limited to the cervix. Pathological examination showed NK/T cell lymphoma, which was supported by histological and immunohistochemical studies and was confirmed by evidence of Epstein-Barr virus infection. Less commonly, this case concerned a cytotoxic T cell phenotype, as molecular studies showed evidence of a clonal T cell receptor γ chain gene rearrangement. Microscopically, prominent and extensive necrosis was the distinctive feature of this case, which reminded us of considering it as a tumor.
  
  
  CONCLUSIONS
  Primary NK/T lymphoma of the cervix is rare. Our experience in this case provided variable information on both pathological and molecular studies. This case may be of value in the differential diagnosis of lymphoid lesions and other small cell tumors of the cervix.
authors: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Guan-Nan
authors: GN
authors: Wang
authors: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Wu-Gan
authors: WG
authors: Zhao
authors: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Xian-Zheng
authors: XZ
authors: Gao
authors: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Dan-Dan
authors: DD
authors: Zhang
authors: Department of Pathology, People's Hospital of XiPing County, XiPing, China.
authors: Guan-Jun
authors: GJ
authors: Wang
authors: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: liwencaipatho@126.com.
authors: Wen-Cai
authors: WC
authors: Li
mesh_terms: D002584:Cervix Uteri / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007813:Laparotomy; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D008875:Middle Aged; D055611:Natural Killer T-Cells / Q000473:pathology*; D016133:Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery
chemical_list: D004273:DNA, Neoplasm
keywords: NK/T cell lymphoma; nasal type; uterine cervix