title: Synthesis of indole terpenoid mimics through a functionality-tolerated Eu(fod)3 -catalyzed conjugate addition.
abstract: The chemical synthesis of indole terpenoids of structural and biological interests has attracted remarkable attention. Here we report an Eu(fod)3 -catalyzed indole conjugate addition reaction, which tolerates various acid-sensitive functional groups. A collection of indole terpenoid mimics have been prepared from natural product-derived α,β-unsaturated enones on the basis of this reaction. The further conversion of the indole adducts into more complex natural product-like molecules has also been demonstrated.
authors: Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 (China); State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China); University of Chinese Academy of Sciences, Beijing 100049 (China).
authors: Xiaochun
authors: X
authors: Xiong
authors: Deliang
authors: D
authors: Zhang
authors: Jian
authors: J
authors: Li
authors: Yu
authors: Y
authors: Sun
authors: Shupeng
authors: S
authors: Zhou
authors: Ming
authors: M
authors: Yang
authors: Huawu
authors: H
authors: Shao
authors: Ang
authors: A
authors: Li
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D005466:Fluorocarbons
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D013729:Terpenes; C009595:tris(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6- octanedionato)europium(III); D005466:Fluorocarbons
keywords: conjugate addition; europium; indoles; natural products; α,β-unsaturated enones