title: [Modern methods of diagnosis of thrombophylic states and complex treatment of patients with thrombotic complications of severe forms of varicose disease].
abstract: Actual issues of surgical treatment of patients, suffering complications of severe forms of varicose disease of the lower extremities (VDLE) are discussed. The causes of unsatisfactory results of treatment in patients, suffering varicothrombophlebitis (VTHPH), the main of which--absence of the only one tactics for operative treatment and anticoagulant therapy, were analyzed. The results of patients examination, suffering thrombotic complications of severe forms of VDLE, while its recurrent course, in conjunction of VTHPH and thrombosis of deep veins of the lower extremities, using diagnostic complex "PLR genetics thrombophilia", are adduced. Differential tactics of treatment in patients, suffering severe forms of VDLE, while various localization of thrombotic process, concerning the presence of thrombophilic states, is proposed.
authors: S P
authors: SP
authors: Shchukin
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D005165:Factor V / Q000235:genetics / Q000378:metabolism; D005167:Factor VII / Q000235:genetics / Q000378:metabolism; D005174:Factor XII / Q000235:genetics / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D039421:Integrin alpha2 / Q000097:blood / Q000235:genetics; D039661:Integrin beta3 / Q000097:blood / Q000235:genetics; D007866:Leg / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009154:Mutation; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics; D011516:Prothrombin / Q000235:genetics / Q000378:metabolism; D019851:Thrombophilia / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery / Q000628:therapy; D014648:Varicose Veins / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery / Q000628:therapy; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery / Q000628:therapy
chemical_list: D000925:Anticoagulants; C000592498:FGB protein, human; C061248:ITGB3 protein, human; D039421:Integrin alpha2; D039661:Integrin beta3; D017395:Plasminogen Activator Inhibitor 1; D005165:Factor V; D005167:Factor VII; D011516:Prothrombin; D005174:Factor XII; D005340:Fibrinogen