title: Microfabrication of gelatin-polycaprolactone composites for customized drug delivery.
abstract: Dynamic properties of water molecules present in the vicinity of protein are sensitive to its local conformational motions. Water mobility at the protein surface/interfaces is affected by its polar and charged groups, which are capable of anchoring water molecules through H-bonds. Differential scanning calorimetry, ATR-FTIR spectroscopy and circular dichroic analysis have been employed to substantiate the changes in hydration of gelatin, interacting with polycaprolactone. Enthalpy of denaturation and decrease in melting temperature indicate alteration in water-bridges around gelatin. In vitro drug release studies substantiate the influence of hydration on its release kinetics. These studies would aid in exploration of potential drug carrier.
authors: Chemical Laboratory, Council of Scientific and Industrial Research, Central Leather Research Institute, Adyar, Chennai 600020, India.
authors: Ivy
authors: I
authors: Kanungo
authors: Chemical Laboratory, Council of Scientific and Industrial Research, Central Leather Research Institute, Adyar, Chennai 600020, India.
authors: Nisha
authors: N
authors: Chellappa
authors: Chemical Laboratory, Council of Scientific and Industrial Research, Central Leather Research Institute, Adyar, Chennai 600020, India. Electronic address: nishad@clri.res.in.
authors: Nishter Nishad
authors: NN
authors: Fathima
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D015198:Designer Drugs / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation / Q000502:physiology; D005615:Freezing; D005780:Gelatin / Q000737:chemistry*; D007700:Kinetics; D055616:Microtechnology / Q000379:methods; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D015198:Designer Drugs; D004337:Drug Carriers; D011091:Polyesters; D014867:Water; C016240:polycaprolactone; D005780:Gelatin
keywords: Biomaterial; Drug delivery; Gelatin; Polycaprolactone; Thermoporometry