title: Therapeutic Opportunities for Self-Control Repair in Addiction and Related Disorders: Change and the Limits of Change in Trans-Disease Processes.
abstract: Contemporary neuro-economic approaches hypothesize that self-control failure results from drugs annexing normal learning mechanisms that produce pathological reward processing and distort decision-making as a result from the dysregulation of two valuation systems. An emphasis on processes shared across different diseases and disorders is at odds with the contemporary approach that assumes unique disease etiologies and treatments. Studying trans-disease processes can identify mechanisms that operate in multiple disease states and ascertain if factors that influence processes in one disease state may be applicable to all disease states. In this paper we review the dual model of self-control failure, the Competing Neurobehavioral Decision Systems approach, the relationship of delay discounting to the relative control of these two systems, and evidence that the executive system can be strengthened. Future research that could result in more potent interventions for executive system improvement and potential constraints on the repair of self-control failure are discussed.
authors: Virginia Tech Carilion Research Institute, Roanoke, VA.
authors: Warren K
authors: WK
authors: Bickel
authors: Virginia Tech Carilion Research Institute, Roanoke, VA.
authors: Amanda J
authors: AJ
authors: Quisenberry
authors: Virginia Tech Carilion Research Institute, Roanoke, VA.
authors: Lara
authors: L
authors: Moody
authors: Virginia Tech Carilion Research Institute, Roanoke, VA.
authors: A George
authors: AG
authors: Wilson
keywords: addiction; competing neurobehavioral decision systems; delay discounting; rate dependence; trans-disease processes; working memory training