title: [Analysis of tumor lysis syndrome in 380 cases of acute leukemia].
abstract: OBJECTIVE
  This studay was aimed to explore the incidence and risk factors of tumor lysis syndrome (TLS) in patients with acute leukemia.
  
  
  METHODS
  A tatol of 380 patients who were newly diagnosed as acute leukemia and received combination chemotherapy were retrospectively analyzed. The TLS was diagnosed according to criteria of Cario and Bioshop, the risk factors were evaluated on basis of examination results.
  
  
  RESULTS
  The tumor lysis syndrome occurred in 20.8% (79/380) of patients, out of them the clinical TLS was 0.5% (2/380), laboratorial TLS was 20.3% (77/380). The unvariate analysis showed that male, high WBC count, hepatomegaly, splenomegaly, lympha-denoctasis, elevated AST, high creatinine, high uric acid level, high serum lactate dehydrogenase (LDH) level, or renal insufficiency were independent risk factors for TLS.
  
  
  CONCLUSIONS
  The TLS is a clinically common complication in patients with leukemia, especially during induction chemotherapy, therefore, for AL patients with high risk factors the TLS should be closely monitored, prevented and given better therapy.
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Qi
authors: Q
authors: Zhang
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Kai-Qi
authors: KQ
authors: Liu
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Bing-Cheng
authors: BC
authors: Liu
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Chun-Lin
authors: CL
authors: Zhou
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Wei
authors: W
authors: Li
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Dong
authors: D
authors: Lin
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Ying
authors: Y
authors: Wang
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. E-mail:miyingch@medmail.com.cn.
authors: Ying-Chang
authors: YC
authors: Mi
authors: Diagnostic and Therapeutic Center of Leukemia, Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
authors: Jian-Xiang
authors: JX
authors: Wang
mesh_terms: D000208:Acute Disease; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy; D007938:Leukemia; D008297:Male; D051437:Renal Insufficiency; D012189:Retrospective Studies; D012307:Risk Factors; D015275:Tumor Lysis Syndrome