title: LncRNA HMlincRNA717 is down-regulated in non-small cell lung cancer and associated with poor prognosis.
abstract: BACKGROUND
  Long non coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets. The lncRNA HMlincRNA717, a newly identified lncRNA, was demonstrated to be down-regulated in gastric cancer. However, little is known about its role in non small cell lung cancer (NSCLC).
  
  
  METHODS
  Expression of lncRNA HMlincRNA717 in tumor and their matched non-tumor tissues was determined by quantitative real-time PCR (qRT-PCR) in NSCLC patients. Then, we analyzed the potential relationship between lncRNA HMlincRNA717 expression levels in tumor tissues and clinicopathological features of NSCLC, and clinical outcome.
  
  
  RESULTS
  lncRNA HMlincRNA717 expression level was significantly decreased in NSCLC tissues in comparison to adjacent non-tumor tissues. It was also proved that HMlincRNA717 expression was to be associated with NSCLC histological grade, and lymph node metastasis. In addition, survival analysis proved that down-regulated HMlincRNA717 expression was associated with poor overall survival of NSCLC patients. Multivariate survival analysis also proved that HMlincRNA717 was an independent prognostic factor for NSCLC patients.
  
  
  CONCLUSIONS
  The present study showed the down-regulation of HMlincRNA717 and its association with tumor progression in human NSCLC. It also provided that HMlincRNA717 expression was an independent prognostic factor for patients with NSCLC, which might be a potential prognostic biomarker and therapeutic target for NSCLC.
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Xiao
authors: X
authors: Xie
authors: Department of Cardio-thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, P. R. China.
authors: Hong-Tao
authors: HT
authors: Liu
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Ju
authors: J
authors: Mei
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Fang-Bao
authors: FB
authors: Ding
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Hai-Bo
authors: HB
authors: Xiao
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Feng-Qing
authors: FQ
authors: Hu
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Rui
authors: R
authors: Hu
authors: Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
authors: Ming-Song
authors: MS
authors: Wang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D062085:RNA, Long Noncoding / Q000096:biosynthesis*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: HMlincRNA717; Long non coding RNA; non small cell lung cancer; prognosis