title: A hybrid IMRT/VMAT technique for the treatment of nasopharyngeal cancer.
abstract: Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P=0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P=0.00). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Nan
authors: N
authors: Zhao
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Ruijie
authors: R
authors: Yang
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Yuliang
authors: Y
authors: Jiang
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Suqing
authors: S
authors: Tian
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Fuxin
authors: F
authors: Guo
authors: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.
authors: Junjie
authors: J
authors: Wang
mesh_terms: D002277:Carcinoma; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D059351:Organ Sparing Treatments; D011874:Radiometry; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies