title: Recent vaccine development for human metapneumovirus.
abstract: Human metapneumovirus (hMPV) and respiratory syncytial virus, its close family member, are two major causes of lower respiratory tract infection in the paediatric population. hMPV is also a common cause of worldwide morbidity and mortality in immunocompromised patients and older adults. Repeated infections occur often, demonstrating a heavy medical burden. However, there is currently no hMPV-specific prevention treatment. This review focuses on the current literature on hMPV vaccine development. We believe that a better understanding of the role(s) of viral proteins in host responses might lead to efficient prophylactic vaccine development.
authors: 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
authors: J
authors: J
authors: Ren
authors: 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
authors: T
authors: T
authors: Phan
authors: 2Institute for Translational Science, University of Texas Medical Branch, Galveston, TX, USA 3Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
authors: X
authors: X
authors: Bao
mesh_terms: D055808:Drug Discovery / Q000639:trends; D054884:Host-Pathogen Interactions; D006801:Humans; D029121:Metapneumovirus / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D014764:Viral Proteins; D014765:Viral Vaccines