title: Localized template-driven functionalization of nanoparticles by dynamic combinatorial chemistry.
abstract: We have developed a method for the localized functionalization of gold nanoparticles using imine-based dynamic combinatorial chemistry. By using DNA templates, amines were grafted on the aldehyde-functionalized nanoparticles only if and where the nanoparticles interacted with the template molecules. Functionalization of the nanoparticles was controlled solely by the DNA template; only amines capable of interacting with DNA were bound to the surface. Interestingly, even though our libraries contained only a handful of simple amines, the DNA sequence influenced their attachment to the surface. Our method opens up new opportunities for the synthesis of multivalent, nanoparticle-based receptors for biomacromolecules.
authors: Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands) http://www.otto-lab.com.
authors: Piotr
authors: P
authors: Nowak
authors: Vittorio
authors: V
authors: Saggiomo
authors: Fatemeh
authors: F
authors: Salehian
authors: Mathieu
authors: M
authors: Colomb-Delsuc
authors: Yang
authors: Y
authors: Han
authors: Sijbren
authors: S
authors: Otto
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles; D013499:Surface Properties
chemical_list: D006046:Gold; D004247:DNA
keywords: dynamic combinatorial chemistry; gold nanoparticles; multivalent interactions; surface functionalization; systems chemistry