title: Enantioselective 6-endo bromoaminocyclization of 2,4-dienyl N-tosylcarbamates catalyzed by a chiral phosphine oxide-Sc(OTf)3 complex. A dramatic additive effect.
abstract: An effective enantioselective 6-endo bromoaminocyclization of 2,4-dienyl N-tosylcarbamates catalyzed by a chiral phosphine oxide-Sc(OTf)3 complex is described. A wide variety of optically active 5-bromo-1,3-oxazinan-2-ones containing various functional groups can be obtained in 61-91% yields and 92-99% ees. An additive, such as NaCl, has been found to be crucial for the reaction process.
authors: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 10090, China.
authors: Hu
authors: H
authors: Huang
authors: Hongjie
authors: H
authors: Pan
authors: Yudong
authors: Y
authors: Cai
authors: Mao
authors: M
authors: Liu
authors: Hua
authors: H
authors: Tian
authors: Yian
authors: Y
authors: Shi