title: Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR.
abstract: We report occupational asthma and rhinitis in a formulation pharmacist, employed in the development of tafenoquine. Tafenoquine is a new anti-malarial drug in development; the pure drug substance has an asthma hazard index of zero and previously was not known to be a respiratory sensitizing agent. The implications of this finding for the refinement of quantitative structural analysis of asthmagenic chemicals are discussed.
authors: Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK, j.cannon@rbht.nhs.uk.
authors: J
authors: J
authors: Cannon
authors: Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK.
authors: B
authors: B
authors: Fitzgerald
authors: Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.
authors: M
authors: M
authors: Seed
authors: Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.
authors: R
authors: R
authors: Agius
authors: Department of Occupational Health, GlaxoSmithKline, Brentford, UK.
authors: A
authors: A
authors: Jiwany
authors: Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK.
authors: P
authors: P
authors: Cullinan
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000009:adverse effects* / Q000627:therapeutic use; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D059366:Asthma, Occupational / Q000175:diagnosis* / Q000209:etiology*; D004345:Drug Industry; D006801:Humans; D008297:Male; D021281:Quantitative Structure-Activity Relationship; D012220:Rhinitis / Q000209:etiology
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; C055852:tafenoquine
keywords: Asthma hazard index; respiratory sensitizer; tafenoquine.