title: The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
abstract: Alzheimer's disease (AD) is the most common senile dementia in the world. Although important progress has been made in understanding the pathogenesis of AD, current therapeutic approaches provide only modest symptomatic relief. In this study, we evaluated the neuroprotective effect of quercetin (25 mg/kg) administration via i.p. injection every 48 h for 3 months on aged (21-24 months old) triple transgenic AD model (3xTg-AD) mice. Our data show that quercetin decreases extracellular β-amyloidosis, tauopathy, astrogliosis and microgliosis in the hippocampus and the amygdala. These results were supported by a significant reduction in the paired helical filament (PHF), β-amyloid (βA) 1-40 and βA 1-42 levels and a decrease in BACE1-mediated cleavage of APP (into CTFβ). Additionally, quercetin induced improved performance on learning and spatial memory tasks and greater risk assessment behavior based on the elevated plus maze test. Together, these findings suggest that quercetin reverses histological hallmarks of AD and protects cognitive and emotional function in aged 3xTg-AD mice.
authors: Neuroscience Group of Antioquia, Cellular and Molecular Neurobiology Area, Faculty of Medicine, University of Antioquia, Calle 70 No. 52-21, Medellin, Colombia.
authors: Angélica Maria
authors: AM
authors: Sabogal-Guáqueta
authors: Neuroscience Group of Antioquia, Cellular and Molecular Neurobiology Area, Faculty of Medicine, University of Antioquia, Calle 70 No. 52-21, Medellin, Colombia.
authors: Juan Ignacio
authors: JI
authors: Muñoz-Manco
authors: Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia; Group of Immunomodulation, Faculty of Medicine, University of Antioquia, Calle 70 No. 52-21, Medellin, Colombia.
authors: Jose R
authors: JR
authors: Ramírez-Pineda
authors: Neuroscience Laboratory, Psychology Department, Universidad Nacional de Colombia, Bogotá, Colombia.
authors: Marisol
authors: M
authors: Lamprea-Rodriguez
authors: Grupo de Investigación en Sustancias Bioactivas, Facultad de Química Farmacéutica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
authors: Edison
authors: E
authors: Osorio
authors: Neuroscience Group of Antioquia, Cellular and Molecular Neurobiology Area, Faculty of Medicine, University of Antioquia, Calle 70 No. 52-21, Medellin, Colombia. Electronic address: patricia.cardonag@udea.edu.co.
authors: Gloria Patricia
authors: GP
authors: Cardona-Gómez
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005911:Gliosis / Q000209:etiology / Q000517:prevention & control; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D019964:Mood Disorders / Q000209:etiology / Q000517:prevention & control*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000473:pathology; D053764:Presenilin-1 / Q000235:genetics; D011794:Quercetin / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects / Q000235:genetics; D016875:tau Proteins / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000975:Antioxidants; D009419:Nerve Tissue Proteins; D053764:Presenilin-1; D016875:tau Proteins; D011794:Quercetin
keywords: Alzheimer's disease; Cognitive function; Neuroprotection; Quercetin; Tauopathy; β-amyloidosis