title: A practical Lewis base catalyzed electrophilic chlorination of arenes and heterocycles.
abstract: A mild phosphine sulfide catalyzed electrophilic halogenation of arenes and heterocycles that utilizes inexpensive and readily available N-halosuccinimides is disclosed. This methodology is shown to efficiently chlorinate diverse aromatics, including simple arenes such as anthracene, and heterocycles such as indoles, pyrrolopyrimidines, and imidazoles. Arenes with Lewis acidic moieties also proved amenable, underscoring the mild nature of this chemistry. Lewis base catalysis was also found to improve several diverse aromatic brominations and iodinations.
authors: Department of Chemistry and Biochemistry, San Diego State University , 5500 Campanile Drive, San Diego, California 92182-1030, United States.
authors: Sean M
authors: SM
authors: Maddox
authors: Christopher J
authors: CJ
authors: Nalbandian
authors: Davis E
authors: DE
authors: Smith
authors: Jeffrey L
authors: JL
authors: Gustafson