title: Effect of previous history of cancer on survival of patients with a second cancer of the head and neck.
abstract: OBJECTIVE
  To provide head and neck squamous cell carcinoma (HNSCC) survival estimates with respect to patient previous history of cancer.
  
  
  METHODS
  Data from ten French population-based cancer registries were used to establish a cohort of all male patients presenting with a HNSCC diagnosed between 1989 and 2004. Vital status was updated until December 31, 2007. The 5-year overall and net survival estimates were assessed using the Kaplan-Meier and Pohar-Perme estimators, respectively. Multivariate Cox regression models were used to assess the effect of cancer history adjusted for age and year of HNSCC diagnosis.
  
  
  RESULTS
  Among the cases of HNSCC, 5553 were localized in the oral cavity, 3646 in the oropharynx, 3793 in the hypopharynx and 4550 in the larynx. From 11.0% to 16.8% of patients presented with a previous history of cancer according to HNSCC. Overall and net survival were closely tied to the presence, or not, of a previous cancer. For example, for carcinoma of the oral cavity, the five-year overall survival was 14.0%, 5.9% and 36.7% in case of previous lung cancer, oesophagus cancer or no cancer history, respectively. Multivariate analyses showed that previous history of cancer was a prognosis factor independent of age and year of diagnosis (p<.001).
  
  
  CONCLUSIONS
  Previous history of cancer is strongly associated with survival among HNSCC patients. Survival estimates based on patients' previous history of cancer will enable clinicians to assess more precisely the prognosis of their patients with respect to this major comorbid condition.
authors: Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085 Strasbourg CEDEX, France; Service de santé publique, Hôpitaux Universitaires de Strasbourg, 1 place de l'hôpital, 67091 Strasbourg CEDEX, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France. Electronic address: jeremie.jegu@unistra.fr.
authors: Jérémie
authors: J
authors: Jégu
authors: Service de Biostatistique, Hospices Civils de Lyon, 162 avenue Lacassagne, F-69003 Lyon, France; Département des maladies chroniques et traumatismes, Institut de Veille Sanitaire, F-94410 Saint-Maurice, France.
authors: Aurélien
authors: A
authors: Belot
authors: Service d'oncologie médicale, Centre Paul Strauss, 3 rue de la porte de l'hôpital, 67000 Strasbourg, France.
authors: Christian
authors: C
authors: Borel
authors: Registre des cancers du Tarn, 1, rue Lavazière, BP 37, 81001 Albi cedex, France; Institut Claudius Regaud, IUCT-O, Registre des Cancers du Tarn, Toulouse F-31059, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Laetitia
authors: L
authors: Daubisse-Marliac
authors: Registre des tumeurs de l'Hérault, Centre de Recherche, 208 rue des Apothicaires, 34298 Montpellier CEDEX 5, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Brigitte
authors: B
authors: Trétarre
authors: Registre des cancers de la Somme, Service Épidémiologie Hygiène et Santé Publique, CHU Nord, 80054 Amiens CEDEX 1, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Olivier
authors: O
authors: Ganry
authors: Registre général des tumeurs du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse, Avenue du Général Harris BP 5026, 14076 Caen CEDEX 05, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Anne-Valérie
authors: AV
authors: Guizard
authors: Registre des cancers de la Manche, Centre Hospitalier Public du Cotentin, 46 rue du Val de Saire, 50102 Cherbourg-Octeville, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Simona
authors: S
authors: Bara
authors: Registre des hémopathies malignes de Basse-Normandie, Unité Fonctionnelle Hospitalo-Universitaire n° 0350, Centre Hospitalier Universitaire, Avenue de la Côte de Nacre, 14033 Caen CEDEX, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Xavier
authors: X
authors: Troussard
authors: Registre des tumeurs digestives du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse, Avenue du Général Harris BP 5026, 14076 Caen CEDEX 05, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Véronique
authors: V
authors: Bouvier
authors: Registre des tumeurs du Doubs et du Territoire de Belfort, EA3181, Centre Hospitalier Universitaire, 25000 Besançon, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Anne-Sophie
authors: AS
authors: Woronoff
authors: Registre des cancers de l'Isère, CHU de Grenoble, Pavillon E BP 217, 38043 Grenoble CEDEX 9, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Marc
authors: M
authors: Colonna
authors: Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085 Strasbourg CEDEX, France; Service de santé publique, Hôpitaux Universitaires de Strasbourg, 1 place de l'hôpital, 67091 Strasbourg CEDEX, France; Service d'épidémiologie et de biostatistique, Centre Paul Strauss, 3 rue de la Porte de l'hôpital, 67065 Strasbourg CEDEX, France; Francim: Réseau français des registres des cancers, Toulouse F-31073, France.
authors: Michel
authors: M
authors: Velten
mesh_terms: D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology*; D016019:Survival Analysis
keywords: Head and neck cancer; Neoplasms; Registries; Second primary; Survival