title: Hepatocellular carcinoma in tyrosinemia type 1 without clear increase of AFP.
abstract: Patients with hereditary tyrosinemia type 1 have an elevated risk of developing hepatocellular carcinoma, especially if initiation of treatment with 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3-cyclohexanedione is delayed. Hepatocellular carcinoma can usually be suspected when there are increased α1-fetoprotein levels and characteristic imaging features. The present case shows that a lack of a clear increase in α1-fetoprotein should still lead to consideration of liver transplantation when imaging features change.
authors: Sections of Metabolic Diseases, and.
authors: Willem G
authors: WG
authors: van Ginkel
authors: Departments of Pathology and.
authors: Annette S H
authors: AS
authors: Gouw
authors: Radiology, University Medical Center of Groningen, University of Groningen, Groningen, Netherlands.
authors: Eric J
authors: EJ
authors: van der Jagt
authors: Hepatobiliary Surgery, and.
authors: Koert P
authors: KP
authors: de Jong
authors: Pediatric Gastroenterology, Beatrix Children's Hospital; Section of.
authors: Henkjan J
authors: HJ
authors: Verkade
authors: Sections of Metabolic Diseases, and f.j.van.spronsen@umcg.nl.
authors: Francjan J
authors: FJ
authors: van Spronsen
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D020176:Tyrosinemias / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: C097353:AFP protein, human; D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins
keywords: 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3-cyclohexanedione; NTBC; hepatocellular carcinoma; tyrosinemia type 1; α-fetoprotein