title: Association between family history risk categories and prevalence of diabetes in Chinese population.
abstract: OBJECTIVE
  To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population.
  
  
  METHODS
  The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age ≥ 20 years) in the 2007-2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes).
  
  
  RESULTS
  The age- and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4-39.7%) in FH2, 20.1% (95% CI: 18.2-22.1%) in FH1, and 8.4% (95% CI: 7.9-8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (ΔI30/ΔG30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46-8.50) and 2.86 (95% CI: 2.41-3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes.
  
  
  CONCLUSIONS
  Family history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Jinping
authors: J
authors: Zhang
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Zhaojun
authors: Z
authors: Yang
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Jianzhong
authors: J
authors: Xiao
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Xiaoyan
authors: X
authors: Xing
authors: Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors: Juming
authors: J
authors: Lu
authors: Department of Endocrinology, Sun Yat-sen University Third Hospital, Guangzhou, China.
authors: Jianping
authors: J
authors: Weng
authors: Department of Endocrinology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors: Weiping
authors: W
authors: Jia
authors: Department of Endocrinology, Peking University People's Hospital, Beijing, China.
authors: Linong
authors: L
authors: Ji
authors: Department of Endocrinology, First Affiliated Hospital, Chinese Medical University, Liaoling, China.
authors: Zhongyan
authors: Z
authors: Shan
authors: Department of Endocrinology, Shanxi Province People's Hospital, Taiyuan, Shanxi, China.
authors: Jie
authors: J
authors: Liu
authors: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Haoming
authors: H
authors: Tian
authors: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi, China.
authors: Qiuhe
authors: Q
authors: Ji
authors: Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
authors: Dalong
authors: D
authors: Zhu
authors: Department of Endocrinology, Xinjiang Uygur Autonomous Region's Hospital, Urmqi, Xinjiang, China.
authors: Jiapu
authors: J
authors: Ge
authors: Department of Endocrinology, Qilu Hospital, Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors: Li
authors: L
authors: Chen
authors: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors: Xiaohui
authors: X
authors: Guo
authors: Department of Endocrinology, Henan Province People's Hospital, Zhengzhou, Henan, China.
authors: Zhigang
authors: Z
authors: Zhao
authors: Department of Endocrinology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors: Qiang
authors: Q
authors: Li
authors: Department of Endocrinology, Xiangya Second Hospital, Changsha, Hunan, China.
authors: Zhiguang
authors: Z
authors: Zhou
authors: Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, Fujiang, China.
authors: Lixiang
authors: L
authors: Lin
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Na
authors: N
authors: Wang
authors: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors: Wenying
authors: W
authors: Yang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D011153:Population; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007328:Insulin