title: Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography.
abstract: Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Lucia
authors: L
authors: Monti
authors: Dept. of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy.
authors: Donatella
authors: D
authors: Donati
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Elisabetta
authors: E
authors: Menci
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Samuele
authors: S
authors: Cioni
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Matteo
authors: M
authors: Bellini
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Irene
authors: I
authors: Grazzini
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Sara
authors: S
authors: Leonini
authors: Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Paolo
authors: P
authors: Galluzzi
authors: Unit of Neuroimaging and Neurointervention, AOUS, Policlinico “Santa Maria alle Scotte”, Viale Mario Bracci, 16—53100 Siena, Italy.
authors: Sandra
authors: S
authors: Bracco
authors: Dept. of Neurology, General Hospital of "S. Donato d'Arezzo", Arezzo, Italy.
authors: Sauro
authors: S
authors: Severi
authors: Unit of Nuclear Medicine, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy.
authors: Luca
authors: L
authors: Burroni
authors: Unit of Endovascular and Percutaneous Therapy, Clinica Nuestra Senora del Rosario, Madrid, Spain.
authors: Alfredo
authors: A
authors: Casasco
authors: Dept. Life Sciences, University of Siena, Siena, Italy.
authors: Lucia
authors: L
authors: Morbidelli
authors: Dept. of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy; Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Emiliano
authors: E
authors: Santarnecchi
authors: Dept. of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy.
authors: Pietro
authors: P
authors: Piu
mesh_terms: D017668:Age of Onset; D015901:Angiography, Digital Subtraction; D001921:Brain / Q000098:blood supply / Q000473:pathology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D006233:Persons with Disabilities; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*; D009929:Organ Size; D012008:Recurrence; D013997:Time Factors