title: Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.
abstract: Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.
authors: Departments of aCognitive Psychology bNeurobehavioral Genetics, University of Trier, Trier, Germany.
authors: Katja K
authors: KK
authors: Schneider
authors: Lilian
authors: L
authors: Hüle
authors: Andrea B
authors: AB
authors: Schote
authors: Jobst
authors: J
authors: Meyer
authors: Christian
authors: C
authors: Frings
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011930:Reaction Time / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*; D012737:Sex Factors; D057190:Stroop Test; D055815:Young Adult
chemical_list: C447158:CHRNA5 protein, human; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic