title: Investigating the transcriptional control of cardiovascular development.
abstract: Transcriptional regulation of thousands of genes instructs complex morphogenetic and molecular events for heart development. Cardiac transcription factors choreograph gene expression at each stage of differentiation by interacting with cofactors, including chromatin-modifying enzymes, and by binding to a constellation of regulatory DNA elements. Here, we present salient examples relevant to cardiovascular development and heart disease, and review techniques that can sharpen our understanding of cardiovascular biology. We discuss the interplay between cardiac transcription factors, cis-regulatory elements, and chromatin as dynamic regulatory networks, to orchestrate sequential deployment of the cardiac gene expression program.
authors: From the Gladstone Institute of Cardiovascular Disease and the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA (I.S.K., E.P.N., B.G.B.); and Department of Anesthesia and Perioperative Care (I.S.K.), Department of Pediatrics (B.G.B.), Cardiovascular Research Institute (B.G.B.), and Institute for Regeneration Medicine (B.G.B.), University of California, San Francisco. kathiriyai@anesthesia.ucsf.edu elphege.nora@gladstone.ucsf.edu bbruneau@gladstone.ucsf.edu.
authors: Irfan S
authors: IS
authors: Kathiriya
authors: From the Gladstone Institute of Cardiovascular Disease and the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA (I.S.K., E.P.N., B.G.B.); and Department of Anesthesia and Perioperative Care (I.S.K.), Department of Pediatrics (B.G.B.), Cardiovascular Research Institute (B.G.B.), and Institute for Regeneration Medicine (B.G.B.), University of California, San Francisco. kathiriyai@anesthesia.ucsf.edu elphege.nora@gladstone.ucsf.edu bbruneau@gladstone.ucsf.edu.
authors: Elphège P
authors: EP
authors: Nora
authors: From the Gladstone Institute of Cardiovascular Disease and the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA (I.S.K., E.P.N., B.G.B.); and Department of Anesthesia and Perioperative Care (I.S.K.), Department of Pediatrics (B.G.B.), Cardiovascular Research Institute (B.G.B.), and Institute for Regeneration Medicine (B.G.B.), University of California, San Francisco. kathiriyai@anesthesia.ucsf.edu elphege.nora@gladstone.ucsf.edu bbruneau@gladstone.ucsf.edu.
authors: Benoit G
authors: BG
authors: Bruneau
mesh_terms: D000818:Animals; D001665:Binding Sites; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D006321:Heart / Q000196:embryology / Q000254:growth & development*; D006801:Humans; D009024:Morphogenesis; D032383:Myocytes, Cardiac / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D014157:Transcription Factors
keywords: cell differentiation; heart diseases; transcription factors; transcriptional networks; transcriptional regulatory elements