title: Prognostic value of ABO blood group in patients with renal cell carcinoma: single-institution results from a large cohort.
abstract: OBJECTIVE
  To evaluate the association between ABO blood group and prognosis in patients with renal cell carcinoma (RCC) undergoing surgery.
  
  
  METHODS
  A review of the nephrectomy database of the Asan Medical Center identified 3,172 consecutive patients who underwent nephrectomy for RCC between 1997 and 2012. Patients were followed up for a median 60.2 months (interquartile range 33-102 months). Recurrence-free (RFS), cancer-specific (CSS), and overall survival (OS) were calculated by the Kaplan-Meier method and compared using the log-rank test. A Cox proportional hazards regression model was used to estimate the prognostic significance of each variable.
  
  
  RESULTS
  Of these 3,172 patients, 915 (28.8 %), 1,057 (33.7 %), 860 (26.7 %) and 340 (10.8 %) were blood types O, A, B, and AB, respectively. ABO blood group was not associated with age, sex, operation method, American Society of Anesthesiologists physical status classification, histologic subtype, or pathological TNM stage. The 5-year OS rates in patients with blood types O, A, B, and AB were 86.0, 86.8, 86.6, and 88.6 %, respectively, and the 10-year OS rates were 78.7, 78.6, 79.1, and 76.9 %, respectively (P = 0.990). ABO blood group was not significantly associated with RFS (P = 0.921) or CSS (P = 0.808). Univariable and multivariable analyses showed that ABO blood group was not a significant prognostic factor of RFS, CSS, or OS.
  
  
  CONCLUSIONS
  Our study found that ABO blood group is not associated with survival outcomes and is not a prognostic factor in patients who underwent surgery for RCC.
authors: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-Gil, Songpa-gu, Seoul, 138-736, Korea.
authors: Chunwoo
authors: C
authors: Lee
authors: Dalsan
authors: D
authors: You
authors: Mooyoung
authors: M
authors: Sohn
authors: In Gab
authors: IG
authors: Jeong
authors: Cheryn
authors: C
authors: Song
authors: Taekmin
authors: T
authors: Kwon
authors: Bumsik
authors: B
authors: Hong
authors: Jun Hyuk
authors: JH
authors: Hong
authors: Hanjong
authors: H
authors: Ahn
authors: Choung-Soo
authors: CS
authors: Kim
mesh_terms: D000017:ABO Blood-Group System / Q000502:physiology*; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000017:ABO Blood-Group System