title: Differentiation and maintenance of long-lived plasma cells.
abstract: Long-lived plasma cells, which mostly reside in the bone marrow have been shown to be vital for protection from recurrent infections. Recent gene-targeting and cell-ablation experiments have solidified the concept that their survival depends on both cell-intrinsic programs and extrinsic factors. The BTB transcription factor ZBTB20, which is expressed at high levels in long-lived plasma cells, is critical for their survival. On the other hand, eosinophils, megakaryocytes and monocytes function to establish a niche for long-lived plasma cells by secreting cytokines and growth factors such as APRIL and IL6.
authors: Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
authors: Kohei
authors: K
authors: Kometani
authors: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, and Graduate School of Frontier Biosciences, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address: kurosaki@ifrec.osaka-u.ac.jp.
authors: Tomohiro
authors: T
authors: Kurosaki
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D060833:Cellular Microenvironment; D018858:Germinal Center / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D006801:Humans; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism