title: Risk factors for mortality in patients with Serratia marcescens bacteremia.
abstract: OBJECTIVE
  Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia.
  
  
  METHODS
  We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality.
  
  
  RESULTS
  The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively].
  
  
  CONCLUSIONS
  Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Sun Bean
authors: SB
authors: Kim
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Yong Duk
authors: YD
authors: Jeon
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Jung Ho
authors: JH
authors: Kim
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Jae Kyoung
authors: JK
authors: Kim
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Hea Won
authors: HW
authors: Ann
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Heun
authors: H
authors: Choi
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Min Hyung
authors: MH
authors: Kim
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Je Eun
authors: JE
authors: Song
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Jin Young
authors: JY
authors: Ahn
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Su Jin
authors: SJ
authors: Jeong
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. smileboy9@yuhs.ac.
authors: Nam Su
authors: NS
authors: Ku
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Sang Hoon
authors: SH
authors: Han
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Jun Yong
authors: JY
authors: Choi
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Young Goo
authors: YG
authors: Song
authors: Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.; AIDS Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: June Myung
authors: JM
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D003428:Cross Infection / Q000401:mortality; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D016868:Serratia Infections / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D012706:Serratia marcescens / Q000187:drug effects / Q000302:isolation & purification*; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Serratia marcescens; bacteremia; mortality; risk factors