title: Influenza virus activation of the interferon system.
abstract: The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.
authors: Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address: mjk3@st-andrews.ac.uk.
authors: Marian J
authors: MJ
authors: Killip
authors: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
authors: Ervin
authors: E
authors: Fodor
authors: Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.
authors: Richard E
authors: RE
authors: Randall
mesh_terms: D003673:Defective Viruses / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000276:immunology* / Q000502:physiology*
chemical_list: D007370:Interferon Type I
keywords: Influenza viruses; Innate immunity; Interferon; RIG-I