title: Risks associated with premature ovarian failure in Han Chinese women.
abstract: In this retrospective study, the relationship between demographic characteristics, past medical history, general lifestyle habits and susceptibility of premature ovarian failure (POF) in Han Chinese population was investigated. Five hundred and fifty-three patients with POF and 400 women with normal ovarian function were recruited. A questionnaire was designed to gather information from responders. Logistic regression was carried out to calculate odds ratios (OR), 95% confidence intervals (95% CI) and P-values. History of pelvic surgery, mumps, having relatives with menstrual abnormalities and exposure to chemical agents were significantly associated with increased risk of POF (OR 5.53 [2.15 to 14.23]; 3.26 [2.38 to 4.47]; 28.12 [8.84 to 89.46]; 4.47 [2.09 to 9.58]). Vegetarian diet, tea and mineral water consumption reduced the risk of POF (OR 0.27 [0.19 to 0.37]; 0.04 [0.03 to 0.07]; 0.63 [0.47 to 0.85], respectively). Heredity, pelvic surgery, mumps and exposure to chemical agents were identified as risk factors for POF, whereas vegetarian diet, tea consumption and mineral water drinking were protective. Therefore, genetic consultation could help those women whose relatives manifested an early or premature menopause to avoid the consequences of possible premature ovarian function cessation. Avoidance of exposure to endocrine disrupters and flavonoids intake should be considered.
authors: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China.
authors: Huidan
authors: H
authors: Wang
authors: State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Haitao
authors: H
authors: Chen
authors: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China.
authors: Yingying
authors: Y
authors: Qin
authors: State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Zhuqing
authors: Z
authors: Shi
authors: Center for Reproductive Medicine, Renji Hospital Affiliated to Shanghai Jiaotong University, 845 Lingshan Road, Shanghai 200120, China.
authors: Xiaoming
authors: X
authors: Zhao
authors: Fudan Institute of Urology and Department of Urology, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, China; Center for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors: Jianfeng
authors: J
authors: Xu
authors: Department of Biology, University of Connecticut, CT, USA.
authors: Bowen
authors: B
authors: Ma
authors: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan 250021, China; Center for Reproductive Medicine, Renji Hospital Affiliated to Shanghai Jiaotong University, 845 Lingshan Road, Shanghai 200120, China. Electronic address: chenzijiang@hotmail.com.
authors: Zi-Jiang
authors: ZJ
authors: Chen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004032:Diet; D005190:Family; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009107:Mumps / Q000150:complications; D016649:Primary Ovarian Insufficiency / Q000209:etiology* / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors
keywords: lifestyle; medical history; premature ovarian failure; risk factors