title: Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes.
abstract: Three-component reaction between RCF2CH2NH2·HCl, NaNO2 and electron-deficient alkynes significantly depends on substituent "R". The reaction gives the fluorinated pyrazoles in high yields when "R" is a fluorine atom or a fluoroalkyl group. With other "R" unexpected products are formed.
authors: Enamine Ltd, vul. Matrosova 23, 01013 Kyiv, Ukraine. Pavel.Mykhailiuk@gmail.com Pavel.Mykhailiuk@mail.enamine.net.
authors: Pavel K
authors: PK
authors: Mykhailiuk
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D004583:Electrons; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D012977:Sodium Nitrite / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D006845:Hydrocarbons, Fluorinated; D011720:Pyrazoles; D012977:Sodium Nitrite