title: Ehlers-Danlos syndrome associated with fatal spontaneous vascular rupture in a dog.
abstract: A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers-Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microscopy of the subclavian artery, revealed abnormalities in the structure and arrangement of collagen fibrils, suggesting that the defective collagen formation extended to the vasculature. To the authors' knowledge, this is the first report of Ehlers-Danlos syndrome with vascular involvement in animals.
authors: Small Animal Veterinary Teaching Hospital, UK. Electronic address: uri.maarja@gmail.com.
authors: M
authors: M
authors: Uri
authors: Section of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Leahurst, Chester High Road, Neston, UK.
authors: R
authors: R
authors: Verin
authors: Section of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Leahurst, Chester High Road, Neston, UK.
authors: L
authors: L
authors: Ressel
authors: Small Animal Veterinary Teaching Hospital, UK.
authors: L
authors: L
authors: Buckley
authors: Small Animal Veterinary Teaching Hospital, UK.
authors: N
authors: N
authors: McEwan
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004535:Ehlers-Danlos Syndrome / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012422:Rupture, Spontaneous / Q000209:etiology; D013348:Subclavian Artery / Q000473:pathology
keywords: Ehlers–Danlos syndrome; defective collagen; dog; vascular rupture