title: Correlation of the plasma levels of soluble RAGE and endogenous secretory RAGE with oxidative stress in pre-diabetic patients.
abstract: BACKGROUND
  Soluble RAGE (sRAGE), endogenous secretory RAGE (esRAGE) and oxidative stress played important roles in the pathogenesis of diabetes and its complications. The changes in sRAGE and esRAGE during pre-diabetes were indefinite.
  
  
  METHODS
  Patients were divided into NGT, pre-diabetes (pre-DM), and newly diagnosed diabetes mellitus (DM) groups according to blood glucose levels. The levels of sRAGE, esRAGE, 8-isoprostaglandin F2α (8-iso-PGF2α), superoxide dismutase (SOD) activity, total antioxidant capacity (TAOC), malondialdehyde (MDA), and other related indicators were then assessed.
  
  
  RESULTS
  sRAGE and esRAGE in the pre-DM and DM groups were significantly lower than in the NGT group (p<0.05). In the pre-DM group, sRAGE was positively correlated with esRAGE (r=0.382, P=0.007), and negatively correlated with homeostasis model assessment-estimated insulin resistance (HOMA-IR), MDA, and 8-iso-PGF2α (r=-0.314, -0.313, and -0.34, P=0.028, 0.028, and 0.016, respectively). The concentration of esRAGE was positively correlated with sRAGE and TAOC (r=0.382 and 0.598, and P=0.007, <0.001), and negatively correlated with MDA (r=-0.397, P=0.005).
  
  
  CONCLUSIONS
  Changes in sRAGE, esRAGE, and oxidative stress occurred in pre-diabetic patients. sRAGE and esRAGE might play an essential role in the balance between oxidative stress and antioxidant defense.
  Changes in sRAGE, esRAGE, and oxidative stress occurred in pre-diabetic patients. THIS STUDY ADDS: sRAGE, esRAGE, and oxidative stress are altered early during pre-diabetes. sRAGE and esRAGE may have played different roles in the balance between oxidative stress and the antioxidant defense.
authors: Zhongshan Hospital Xiamen University.
authors: Minglian
authors: M
authors: Huang
authors: Zhongshan Hospital Xiamen University.
authors: Yanyan
authors: Y
authors: Que
authors: Zhongshan Hospital Xiamen University. Electronic address: sxpsxzlg@hotmail.com.
authors: Xingping
authors: X
authors: Shen
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011236:Prediabetic State / Q000097:blood* / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: C000593871:AGER protein, human; D000975:Antioxidants; D000067759:Receptor for Advanced Glycation End Products; C000593877:esRAGE protein, human; D013482:Superoxide Dismutase
keywords: Diabetes; Oxidative stress; Pre-diabetes; esRAGE; sRAGE