title: Inflammatory markers in ST-elevation acute myocardial infarction.
abstract: After acute myocardial infarction, ventricular remodeling is characterized by changes at the molecular, structural, geometrical and functional level that determine progression to heart failure. Inflammation plays a key role in wound healing and scar formation, affecting ventricular remodeling. Several, rather different, components of the inflammatory response were studied as biomarkers in ST-elevation acute myocardial infarction. Widely available and inexpensive tests, such as leukocyte count at admission, as well as more sophisticated immunoassays provide powerful predictors of adverse outcome in patients with ST-elevation acute myocardial infarction. We review the value of inflammatory markers in ST-elevation acute myocardial infarction and their association with ventricular remodeling, heart failure and sudden death. In conclusion, the use of these biomarkers may identify subjects at greater risk of adverse events and perhaps provide an insight into the mechanisms of disease progression.
authors: Interventional Cardiology Department, Hospital Italiano de Buenos Aires, Argentina.
authors: Ignacio M
authors: IM
authors: Seropian
authors: VCU Pauley Heart Center, Virginia Commonwealth University, USA Victoria Johnson Research Laboratory, Virginia Commonwealth University, USA Department of Cardiovascular Medicine, Catholic University, Italy.
authors: Chiara
authors: C
authors: Sonnino
authors: VCU Pauley Heart Center, Virginia Commonwealth University, USA Victoria Johnson Research Laboratory, Virginia Commonwealth University, USA School of Pharmacy, Virginia Commonwealth University, USA.
authors: Benjamin W
authors: BW
authors: Van Tassell
authors: Department of Cardiovascular Medicine, Catholic University, Italy.
authors: Luigi M
authors: LM
authors: Biasucci
authors: VCU Pauley Heart Center, Virginia Commonwealth University, USA Victoria Johnson Research Laboratory, Virginia Commonwealth University, USA aabbate@mchv-vcu.edu.
authors: Antonio
authors: A
authors: Abbate
mesh_terms: D015415:Biomarkers / Q000097:blood*; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D011379:Prognosis; D000072657:ST Elevation Myocardial Infarction / Q000276:immunology* / Q000473:pathology; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines
keywords: Inflammation; ST-elevation acute myocardial infarction; biological markers; ventricular remodeling