title: Myogenesis in the genomics era.
abstract: Skeletal myogenesis is the process of formation of the muscles that enable movement and breathing. Muscles form after the fate determination and differentiation of precursor cells. Being an extraordinarily complex process, myogenesis is regulated at multiple levels, and transcriptional regulation naturally plays a big part in the making of muscle. A significant part of what we know today of the transcriptional regulatory networks overseeing myogenesis comes from large-scale functional genomics studies. The objective of this review is to provide an overview of the various genomics techniques that have been employed over the years to understand myogenic regulation, to give a sense of the degree of understanding they have provided us up to now, and to highlight the next challenges to be overcome.
authors: Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada. Electronic address: alexandre.blais@uottawa.ca.
authors: Alexandre
authors: A
authors: Blais
mesh_terms: D000818:Animals; D057890:Epigenomics / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods*; D018507:Gene Expression Regulation, Developmental; D023281:Genomics / Q000379:methods*; D006801:Humans; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors
keywords: chromatin structure; epigenetics; myogenesis; transcription factors; transcriptional regulatory network