title: [Application of autologous mesenchymal stromal cells in treatment of the extremities bones defects].
abstract: Possibilities of clinical application of a three dimensional osteoprogenitoral transplant (TDOPT), background of autologous mesenchymal stromal cells (MCK), were studied for treatment of the extremity bone defects. Twelve patients were included in the investigation, in whom the defects of brachial, femoral, tibial and the heel bones were revealed. In 8 patients a cicatricial-ulcerative defects of soft tissues were present over the bone defects. TDOPT in a kind of "chips" were applied in tangential bone defects, while in full defects they were applied in a kind of blocks. For substitution of the soft tissue defects the fascio-cutaneous and muscular flaps on pedicles were used. Possibility of the TDOPT application in the treatment of the bone tissue defects and their high efficacy were substantiated.
authors: V M
authors: VM
authors: Oksimets
mesh_terms: D000328:Adult; D018483:Diaphyses / Q000293:injuries; D005269:Femur / Q000293:injuries; D050723:Fractures, Bone / Q000534:rehabilitation / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods* / Q000534:rehabilitation; D000070599:Shoulder Injuries; D017695:Soft Tissue Injuries / Q000534:rehabilitation / Q000601:surgery* / Q000628:therapy; D013524:Surgical Flaps; D013977:Tibia / Q000293:injuries; D014182:Transplantation, Autologous; D016896:Treatment Outcome