title: [Research progress on multiple myeloma immunophenotyping and minimal residual disease detected by flow cytometry].
abstract: Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow and remained incurable. Flow cytometry has been widely used in the detection of immunophenotype and minimal residual disease, diagnosis, monitoring and prognosis of MM. Normal plasma cells and malignant plasma cells can be distinguished according to different cell surface antigen expression. The clinical significane of many immune markes has been elucidated. However, the clinical significance of some phenotype remains controversial, the detection scheme and gating strategy are not unified. This review discusses the recent research progress on detection of MM immunophenotype and minimal residual disease by flow cytovetry.
authors: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu Province, China.
authors: Han-Qing
authors: HQ
authors: Li
authors: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu Province, China. E-mail: ypzhaicn@yahoo.com.cn.
authors: Yong-Ping
authors: YP
authors: Zhai
mesh_terms: D000954:Antigens, Surface; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D009101:Multiple Myeloma; D018365:Neoplasm, Residual; D010641:Phenotype; D010950:Plasma Cells; D011379:Prognosis
chemical_list: D000954:Antigens, Surface