title: Nickel-promoted highly regioselective carboxylation of aryl ynol ether and its application to the synthesis of chiral β-aryloxypropionic acid derivatives.
abstract: Nickel(0)-promoted carboxylation of aryl ynol ether proceeded in a highly regioselective manner to produce α-substituted-β-aryloxyacrylic acid derivatives. The α-substituted-β-aryloxyacrylic acids were transformed into the corresponding β-aryloxypropionic acid derivative as an optically active form via rhodium-catalyzed asymmetric hydrogenation.
authors: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812 (Japan). nozomi-s@pharm.hokudai.ac.jp.
authors: Nozomi
authors: N
authors: Saito
authors: Zhongdong
authors: Z
authors: Sun
authors: Yoshihiro
authors: Y
authors: Sato
mesh_terms: D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004987:Ethers; D009942:Organometallic Compounds; D011422:Propionates; D009532:Nickel
keywords: asymmetric catalysis; carbon dioxide; nickel; rhodium; ynol ether