title: Vaccination to modulate atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory disease of the artery wall. Adaptive immunity plays a key role in the pathogenesis of atherosclerosis. Recently, modulation of the immune response against atherosclerotic plaque antigen(s) has attracted attention as a potentially preventive and therapeutic approach. Here, we review a series of studies on immunization with various antigens targeting treatment and prevention of atherosclerosis. Atherosclerosis-related antigens include oxidized low-density lipoprotein (LDL), apolipoprotein B-100 (ApoB-100) and heat shock protein (HSP) 60/65. Accumulating evidence supports the idea that immunization with these antigenic proteins or peptides may reduce atherosclerosis. In this review, we discuss the current status of immunization studies and possible associated mechanisms of atheroprotection.
authors: Division of Inflammation Biology and.
authors: Takayuki
authors: T
authors: Kimura
authors: Kevin
authors: K
authors: Tse
authors: Alessandro
authors: A
authors: Sette
authors: Klaus
authors: K
authors: Ley
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D053299:Apolipoprotein B-100 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D001158:Arteries / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D050197:Atherosclerosis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D051379:Mice; D010455:Peptides / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D058226:Plaque, Atherosclerotic / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
chemical_list: D000906:Antibodies; D053299:Apolipoprotein B-100; D001324:Autoantigens; D006360:Heat-Shock Proteins; D008077:Lipoproteins, LDL; D010455:Peptides; D014612:Vaccines; C099252:oxidized low density lipoprotein; C060293:HSPD1 protein, human; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
keywords: Apolipoprotein B-100; atherosclerosis; heat shock protein 65; immunization; low-density lipoprotein