title: Tumor necrosis factor stimulates expression of CXCL12 in astrocytes.
abstract: It has been increasingly appreciated that tumor necrosis factor (TNF) performs various protective and anti-inflammatory functions in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key inhibitor of leukocyte entry into the central nervous system (CNS) and as a regulator of inflammation resulting from the invasion. Here, a positive correlation between expression of TNF and CXCL12 in the CNS samples of EAE rats is presented. Also, it is shown that TNF potentiates CXCL12 expression in astrocytes. These results contribute to a view that TNF produced within the CNS plays a protective role in neuroinflammation.
authors: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia.
authors: Jana
authors: J
authors: Blaževski
authors: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia.
authors: Filip
authors: F
authors: Petković
authors: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia.
authors: Miljana
authors: M
authors: Momčilović
authors: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia.
authors: Bojan
authors: B
authors: Jevtić
authors: Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Serbia.
authors: Marija
authors: M
authors: Mostarica Stojković
authors: Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia. Electronic address: djordjem@ibiss.bg.ac.rs.
authors: Djordje
authors: D
authors: Miljković
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002465:Cell Movement; D002478:Cells, Cultured; D054377:Chemokine CXCL12 / Q000096:biosynthesis*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D007962:Leukocytes / Q000378:metabolism; D009103:Multiple Sclerosis / Q000276:immunology; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: C575935:CXCL12 protein, rat; D054377:Chemokine CXCL12; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha
keywords: Astrocyte; CXCL12; Experimental autoimmune encephalomyelitis; Neuroinflammation; Tumor necrosis factor