title: MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder.
abstract: Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, and miR-29c in Parkinson disease. Here we investigated the expression of these microRNAs in serum samples from 56 patients with idiopathic rapid eye movement sleep behavior disorder, before and after their conversion into a synucleinopathy. Compared to controls, we found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67 ± 2.61 years of follow-up. Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.
authors: Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona; Center for Biomedical Research in Neurodegenerative Diseases, Madrid.
authors: Rubén
authors: R
authors: Fernández-Santiago
authors: Alex
authors: A
authors: Iranzo
authors: Carles
authors: C
authors: Gaig
authors: Mónica
authors: M
authors: Serradell
authors: Manel
authors: M
authors: Fernández
authors: Eduardo
authors: E
authors: Tolosa
authors: Joan
authors: J
authors: Santamaría
authors: Mario
authors: M
authors: Ezquerra
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D020187:REM Sleep Behavior Disorder / Q000097:blood* / Q000175:diagnosis*; D051843:Synucleins / Q000097:blood*
chemical_list: D015415:Biomarkers; C549214:MIRN19A microRNA, human; D035683:MicroRNAs; D051843:Synucleins