title: Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia.
abstract: We report the case of a 49-year-old woman with homozygous familial hypercholesterolemia and a complicated cardiovascular history, treated for 5 years with a microsomal triglyceride transfer protein inhibitor in addition to her other lipid-lowering therapy.
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Anna
authors: A
authors: Raper
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Daniel M
authors: DM
authors: Kolansky
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Bruce S
authors: BS
authors: Sachais
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Emma A
authors: EA
authors: Meagher
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
authors: Amanda L
authors: AL
authors: Baer
authors: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: mcuchel@mail.med.upenn.edu.
authors: Marina
authors: M
authors: Cuchel
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D001781:Blood Component Removal; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011859:Radiography
chemical_list: D000924:Anticholesteremic Agents; D000925:Anticoagulants; C473731:BMS201038; D001562:Benzimidazoles; D002352:Carrier Proteins; C106092:microsomal triglyceride transfer protein; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: CYP3A4 inhibitors; Cholesterol; Homozygous familial hypercholesterolemia; Liver function tests; Lomitapide; MTP inhibitor; Warfarin