title: Cell-penetrating Peptides for Cancer-targeting Therapy and Imaging.
abstract: Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport vector tools for the delivery of a large variety of cargoes through the cell membrane, as well as other physiological membranes. And since they're relatively cell-, receptor- and energy-independent, CPPs have unique advantages in facilitating drugs entry into cells. This paper briefly reviews the discovery, mechanism and classification of CPPs, and especially focuses on the specific limitations of CPPs and their potential applications for tumor-targeted delivery of biologically active molecules, imaging agents and carriers.
authors: Weiqin
authors: W
authors: Wang
authors: Sarra
authors: S
authors: Abbad
authors: Zhenhai
authors: Z
authors: Zhang
authors: Shu
authors: S
authors: Wang
authors: Jianping
authors: J
authors: Zhou
authors: Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China, 211198. iamzhoujianping@163.com.
authors: Huixia
authors: H
authors: Lv
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000145:classification / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers