title: Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.
abstract: OBJECTIVE
  To investigate the association of three polymorphisms in the Interleukin-27 (IL-27) gene with CD risk in Chinese population.
  
  
  METHODS
  This case-control study involved 312 CD patients and 479 age- and sex-matched healthy controls. Genotyping was performed using PCR-LDR method. Data were analyzed using Haplo. Stats program.
  
  
  RESULTS
  There were significant differences between patients and controls in allele distributions of rs153109 (Pallele = 0.036). The risk for CD associated with the rs153109-G mutant allele was increased by 26% (95% CI [confidence interval]: 1.02-1.56; P = 0.03) under the additive model and by 45% (95% CI: 1.07-1.97; P = 0.02) under the dominant model. In haplotype analysis, haplotype T-T-G (in order of rs17855750, rs181206 and rs153109) increased the odds of CD by 37% (95% CI: 1.04-1.81; P = 0.028).
  
  
  CONCLUSIONS
  In conclusion, genetic defects in IL-27 gene showed remarkable associations with CD in Chinese.
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
authors: Zhengting
authors: Z
authors: Wang
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
authors: Lei
authors: L
authors: Wang
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
authors: Rong
authors: R
authors: Fan
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
authors: Jie
authors: J
authors: Zhou
authors: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200025, China.
authors: Jie
authors: J
authors: Zhong
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: Crohn’s diseases; IL-27; association study; polymorphism; susceptibility