title: Porous chitosan-supported metal tetra(4-carboxyphenyl)porphyrin as a practical model for the hydrophobic pocket/cavity of cytochrome P-450 enzyme.
abstract: The objective of this study was to investigate porous chitosan-supported metal tetra(4-carboxyphenyl)porphyrin [Me TCPP/p-CTS] as a practical model for the structure and function of the hydrophobic pocket cavity in cytochrome P-450 enzyme. Porous and non-porous chitosan-supported Me TCPPs [Me TCPP/p- and nonp-CTS] were prepared by a similar procedure, characterized using various techniques, and then used as catalysts for the aerobic oxidation of cyclohexane. The Me TCPP/p-CTS, which contained many cavities, showed higher catalytic activity than the Me TCPP/nonp-CTS. The catalytic activities of Mn TCPP/p-CTS and Fe TCPP/p-CTS were 12.4% and 24.4% greater than those of Mn TCPP/nonp-CTS and Fe TCPP/nonp-CTS, respectively. These differences in catalytic activity were mainly influenced by the characteristics and numbers of cavities (or pores) contained in the supported catalysts.
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. Electronic address: huangg66@126.com.
authors: Guan
authors: G
authors: Huang
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
authors: Pei
authors: P
authors: Wang
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
authors: Li
authors: L
authors: Shen
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
authors: Yan-Xun
authors: YX
authors: Wei
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
authors: Kai
authors: K
authors: Zeng
authors: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
authors: Su-Juan
authors: SJ
authors: Wei
mesh_terms: D002384:Catalysis; D048271:Chitosan / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008665:Metalloporphyrins / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D010084:Oxidation-Reduction; D016062:Porosity; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D008665:Metalloporphyrins; D008670:Metals; D011166:Porphyrins; D048271:Chitosan; D003577:Cytochrome P-450 Enzyme System
keywords: Cyclohexane; Immobilization; Metal porphyrin; Oxidation; Porous chitosan