title: Bronchiolitis obliterans associated with Stevens-Johnson syndrome: a case report.
abstract: We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous airway disease. On physical examination, expiratory breathing sounds were not audible, and a chest X-ray revealed a hyperinflated lung. A pulmonary function test indicated a severe obstructive pattern. Computed tomography scans of inspiratory and expiratory phases of respiration showed oligemia and air trapping, and both were more prominent on expiration view than on inspiration view. The pathogenesis of bronchiolitis obliterans associated with Stevens-Johnson syndrome is largely unknown.
authors: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Hyungchul
authors: H
authors: Park
authors: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Young Bo
authors: YB
authors: Ko
authors: Division of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Hyouk-Soo
authors: HS
authors: Kwon
authors: Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cmlim@amc.seoul.kr.
authors: Chae-Man
authors: CM
authors: Lim
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D001999:Bronchoscopy; D004417:Dyspnea / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000628:therapy; D012129:Respiratory Function Tests; D015575:Roxithromycin / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D014139:Tracheostomy
chemical_list: D000900:Anti-Bacterial Agents; D015575:Roxithromycin
keywords: Stevens-Johnson syndrome; bronchiolitis obliterans; dyspnea