title: Dilute betadine lavage reduces implant-related bacterial burden in a rabbit knee prosthetic infection model.
abstract: Treatment of acute postoperative arthroplasty infection with polyethylene exchange and retention of components has a limited success rate, potentially because of residual bacterial burden. We hypothesized that dilute Betadine (povidone-iodine) lavage would decrease bacterial burden in a rabbit knee infection model. We inserted a stainless steel screw with a polyethylene washer into the lateral femoral condyle in 16 bilateral rabbit knees, and the sites were infected with Staphylococcus aureus. After 1 week, all knees were treated with a polyethylene washer exchange and either a saline lavage or a 3.5% Betadine lavage. We assessed bacterial growth after 7 days. Betadine-treated knees showed a statistically significant decrease in the bacterial count on the stainless steel screw and polyethylene washer but no difference in soft-tissue growth. Betadine lavage as a treatment adjunct may improve component retention for acute arthroplasty infection.
authors: Mohit
authors: M
authors: Gilotra
authors: Thao
authors: T
authors: Nguyen
authors: David
authors: D
authors: Jaffe
authors: Department of Orthopaedic Surgery, Johns Hopkins Bayview Medical Center, Baltimore, MD. rsterli6@jhmi.edu.
authors: Robert
authors: R
authors: Sterling
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D020878:Device Removal; D004195:Disease Models, Animal; D011206:Povidone-Iodine / Q000008:administration & dosage*; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000601:surgery*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000601:surgery*; D013211:Staphylococcus aureus; D007507:Therapeutic Irrigation
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine