title: Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors.
abstract: A new method for the fabrication of a label-free electrochemical immunosensor based on vertical nanowires (VNWs) is proposed. The VNWs are functionalized to detect antibodies against a major astrocytic structural protein component, glial fibrillary acidic protein (GFAP). It is revealed that the interaction of GFAP-antibody with functionalized VNWs leads to a clear change in device conductance and the corresponding capacitance.
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.
authors: Babak
authors: B
authors: Nasr
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Psychiatry, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3050, Australia.
authors: Gursharan
authors: G
authors: Chana
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Psychiatry, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3050, Australia.
authors: Ting Ting
authors: TT
authors: Lee
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.
authors: Thanh
authors: T
authors: Nguyen
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.
authors: Chathurika
authors: C
authors: Abeyrathne
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.
authors: Giovanna M
authors: GM
authors: D'Abaco
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.
authors: Mirella
authors: M
authors: Dottori
authors: Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.|Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria, 3010, Australia.|Department of Psychiatry, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3050, Australia.
authors: Efstratios
authors: E
authors: Skafidas
mesh_terms: D000906:Antibodies / Q000378:metabolism; D015374:Biosensing Techniques / Q000295:instrumentation*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D005455:Fluorescent Antibody Technique; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation*; D053770:Nanowires; D011485:Protein Binding
chemical_list: D000906:Antibodies; D005904:Glial Fibrillary Acidic Protein
keywords: biosensors; electrode arrays; label-free detection; nanowires; silicon