title: Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment.
abstract: We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50μg/kg/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and α-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the luminal and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors: Lucía
authors: L
authors: Vigezzi
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors: Verónica L
authors: VL
authors: Bosquiazzo
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors: Laura
authors: L
authors: Kass
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors: Jorge G
authors: JG
authors: Ramos
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors: Mónica
authors: M
authors: Muñoz-de-Toro
authors: Instituto de Salud y Ambiente del Litoral (ISAL) - CONICET, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address: eluque@fbcb.unl.edu.ar.
authors: Enrique H
authors: EH
authors: Luque
mesh_terms: D000818:Animals; D017209:Apoptosis; D001284:Atrophy; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D007774:Lactation; D010052:Ovariectomy; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014599:Uterus / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004958:Estradiol; D010636:Phenols; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Rat; Steroid receptors; Uterine glands; Uterus; p63