title: Role of rCBV values derived from dynamic susceptibility contrast-enhanced magnetic resonance imaging in differentiating CNS lymphoma from high grade glioma: a meta-analysis.
abstract: OBJECTIVE
  In the preoperative period, discriminating CNS lymphoma from high grade glioma is important as treatment approaches differ significantly. Hence, this meta-analysis was to evaluate the sensitivity and specificity of the relative cerebral blood volume (rCBV) values derived from dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSCE-MRI) in differentiating CNS lymphoma from high grade glioma.
  
  
  METHODS
  The following databases were searched from January 2000 to July 2014: Medline, PubMed and Embase. No language restrictions were applied. Data analysis was conducted using Meta-Disc 1.4.
  
  
  RESULTS
  A total of 79 patients (n = 30 lymphoma, n = 49 high grade glioma) and 89 lesions (n = 40 lymphoma, n = 49 high grade glioma) were included in the rCBV analysis. The pooled sensitivity, specificity, negative likelihood ratio, positive likelihood ratio and diagnostic odds ratio for differentiating CNS lymphoma from high grade glioma were 0.90 (95% CI 0.76-0.97), 0.98 (95% CI 0.89-1.00), 0.13 (95% CI 0.06-0.29), 21.07 (95% CI 5.61-79.19), and 187.63 (95% CI 33.15-1061.86), respectively. And the value of I(2) of DOR was 0.0%, indicating that there was no statistically significant heterogeneity of DOR between the included studies.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that the rCBV values derived from DSCE-MRI could be useful in differentiating CNS lymphoma from high grade glioma in the preoperative. Further well-designed researches involving larger patient cohorts are needed to confirm this conclusion.
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Ruofei
authors: R
authors: Liang
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Mao
authors: M
authors: Li
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Xiang
authors: X
authors: Wang
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Jiewen
authors: J
authors: Luo
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Yuan
authors: Y
authors: Yang
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Qing
authors: Q
authors: Mao
authors: Department of Neurosurgery, West China Hospital of Sichuan University Chengdu, P. R. China.
authors: Yanhui
authors: Y
authors: Liu
keywords: CNS lymphoma; high grade glioma; meta-analysis; rCBV values