title: Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.
abstract: The purpose of this study was to evaluate the relation between the L-FABP T94A and MTP I128T polymorphisms and hyperlipidemia in Chinese subjects. We recruited 390 volunteers: 201 hyperlipidemic and 189 healthy volunteers. The L-FABP T94A and MTP I128T polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Anthropometry, lipid profile, and liver function of the subjects were determined. We observed that male carriers of the L-FABP A94 allele had significantly higher body weight (P = 0.012), higher body mass index (BMI) (P = 0.014), and higher plasma triacylglycerol levels (TAG) (P = 0.033) and lower ratios of high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) (P = 0.008) than T94 homozygotes. The MTP T128 allele was associated with significantly lower serum TC (P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (P < 0.001) levels in males. There was a direct correlation between the MTP T128 allele and a decreased risk of hyperlipidemia after adjusting for body mass index (OR = 0.327, 95 % CI: 0.178-0.600, P < 0.001). In conclusion, both the MTP I128T and the L-FABP T94A polymorphisms can affect serum lipid levels in the Chinese population. The MTP T128 allele offers protection against hyperlipidemia in the Chinese population.
authors: Department of Clinical Pharmacology of Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, Changsha, 410078, China.
authors: Yingying
authors: Y
authors: Tian
authors: Hui
authors: H
authors: Li
authors: Shanbo
authors: S
authors: Wang
authors: Jin
authors: J
authors: Yan
authors: Zhiheng
authors: Z
authors: Chen
authors: Zhenyu
authors: Z
authors: Li
authors: Han
authors: H
authors: Feng
authors: Honghao
authors: H
authors: Zhou
authors: Dongsheng
authors: D
authors: Ouyang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins