title: Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome.
abstract: To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol-induced oxidative stress on the cerebral cortex of newborn rat pups and assess the protective and beneficial effects of BA supplementation on rats with FAS. Pregnant rats were divided into three groups, namely the control, alcohol and alcohol + boric acid groups. As markers of alcohol-induced oxidative stress in the cerebral cortex of the newborn pups, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were measured. Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01). The CAT activity of the alcohol + boric acid group was significantly higher than that in the alcohol group (P<0.05). The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05). These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.
authors: Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Bilim University, Istanbul 34394, Turkey.
authors: Ibrahim
authors: I
authors: Sogut
authors: Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey.
authors: Aysegul
authors: A
authors: Oglakci
authors: Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey.
authors: Kazim
authors: K
authors: Kartkaya
authors: Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey.
authors: Kevser Kusat
authors: KK
authors: Ol
authors: Department of Genetics and Bioengineering, Yeditepe University, Istanbul 34755, Turkey.
authors: Melis Savasan
authors: MS
authors: Sogut
authors: Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey.
authors: Gungor
authors: G
authors: Kanbak
authors: Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey.
authors: Mine Erden
authors: ME
authors: Inal
keywords: boric acid; catalase; fetal alcohol syndrome; glutathione peroxidase; malondialdehyde; superoxide dismutase