title: Association of the single-nucleotide polymorphism and haplotype of the complement receptor 1 gene with malaria.
abstract: OBJECTIVE
  Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with severe malaria remains controversial. Furthermore, no study has examined the association of CR1 polymorphisms with malaria in Chinese population. Therefore, we investigated the relationship of CR1 gene polymorphism and malaria in Chinese population.
  
  
  METHODS
  We analyzed polymorphisms of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T in 509 patients with malaria and 503 controls, using the Taqman genotyping assay and PCR-direct sequencing.
  
  
  RESULTS
  There were no significant differences in the genotype, allele and haplotype frequencies of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms between patients with malaria and controls. Furthermore, there was no association of polymorphisms in the CR1 gene with the severity of malaria in Chinese population.
  
  
  CONCLUSIONS
  These findings suggest that CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms may not be involved in susceptibility to malaria in Chinese population.
authors: Department of Dermatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Yan
authors: Y
authors: Lan
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Chuan-Dong
authors: CD
authors: Wei
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Wen-Cheng
authors: WC
authors: Chen
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Jun-Li
authors: JL
authors: Wang
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Chun-Fang
authors: CF
authors: Wang
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China.
authors: Guo-Gang
authors: GG
authors: Pan
authors: Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China. wysh22@163.com.
authors: Ye-Sheng
authors: YS
authors: Wei
authors: Institute of Medical Laboratory, Youjiang Medical University for Nationalities, Baise, Guangxi, P. R. China. yyfynlg@163.com.
authors: Le-Gen
authors: LG
authors: Nong
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008288:Malaria / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011951:Receptors, Complement / Q000097:blood / Q000235:genetics*; D019914:Taq Polymerase
chemical_list: D011951:Receptors, Complement; D019914:Taq Polymerase
keywords: Erythrocyte complement receptor type 1; gene; haplotype; malaria; polymorphism