title: Neurofilament Light Chain Determination from Peripheral Blood Samples.
abstract: The loss of neurological function is closely related to axonal damage. Neurofilament subunits are concentrated in neurons and axons and have emerged as promising biomarkers for neurodegeneration. Electrochemiluminescence (ECL) based assays are known to be of superior sensitivity and require less sample volume than conventional ELISAs. Here, we describe a highly sensitive ECL based immunoassay for quantification of neurofilament light chain (NfL) in blood and CSF.
authors: Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
authors: Marguerite
authors: M
authors: Limberg
authors: Giulio
authors: G
authors: Disanto
authors: Christian
authors: C
authors: Barro
authors: Jens
authors: J
authors: Kuhle
mesh_terms: D015415:Biomarkers; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D016900:Neurofilament Proteins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016900:Neurofilament Proteins; C044882:neurofilament protein L