title: [The association of Parkinson's disease pathogenesis with inflammation].
abstract: Recent research on pathogenesis of neurodegenerative diseases has revealed that neuroinflammation derived from glial activation enhances the progression of devastating diseases including Parkinson's disease (PD). Although whether or not PD-onset is triggered by neuroinflammatory mechanisms remains unclear, various experimental evidences mainly using cellular and mice models have suggested that cytokines like IL-1β, TNFα and IL-6, and secreted α-synuclein from the neurons activate the microglias, resulting in the disease exacerbation. Also, levels of serum/plasma cytokines such as IL-1β, TNFα, IL-2 and ApoA1 have been reported to be significantly elevated in patients with PD compared to the controls. In this summary, I will report the present status of PD pathogenesis associated with neuroinflammation based on the latest reports associated with PD molecular mechanism focusing on the neuroinflammation.
authors: Department of Neurology, Juntendo University School of Medicine.
authors: Shinji
authors: S
authors: Saiki
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation; D017628:Microglia / Q000502:physiology; D010300:Parkinson Disease / Q000209:etiology*; D051381:Rats
chemical_list: D016207:Cytokines