title: Fabrication, biodegradation behavior and cytotoxicity of Mg-nanodiamond composites for implant application.
abstract: Mg-based biodegradable implants offer several advantages over their non-degradable or degradable polymeric counterparts used today. However, the low corrosion resistance of Mg in physiologic environment remained as concerns. In this research, nanodiamond (ND) was uniformly dispersed in Mg matrix to induce a protective layer on Mg surface during corrosion. Compared with pure Mg, fabricated Mg-ND nanocomposites had lower corrosion rates, higher corrosion potential, and higher corrosion resistance. Specifically, the corrosion rate of Mg was reduced by 4.5 times by adding 5 wt% of ND particles. Corrosion inhibition effect of ND was thus validated. The chemical interaction and physical adsorption of the ions from simulated body fluid on ND might be the main reason for enhanced corrosion resistance. In vitro biocompatibility test results indicated that Mg-ND nanocomposites were biocompatible since cells growing in contact with corrosion products of Mg-ND maintained high cell viability and healthy morphology. Therefore, Mg-ND nanocomposites with homogenous ND dispersion, enhanced corrosion resistance, and good biocompatibility might be an excellent candidate material for biodegradable implant application.
authors: Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA.
authors: Haibo
authors: H
authors: Gong
authors: Babak
authors: B
authors: Anasori
authors: Chris R
authors: CR
authors: Dennison
authors: Kun
authors: K
authors: Wang
authors: E Caglan
authors: EC
authors: Kumbur
authors: Randy
authors: R
authors: Strich
authors: Jack G
authors: JG
authors: Zhou
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001826:Body Fluids / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000633:toxicity; D003343:Corrosion; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D006244:Hardness; D008274:Magnesium / Q000737:chemistry* / Q000633:toxicity*; D008422:Materials Testing; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D058612:Nanodiamonds / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D010316:Particle Size; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D058612:Nanodiamonds; D008274:Magnesium