title: Five-aminosalicylic Acid: an update for the reappraisal of an old drug.
abstract: Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA) and its derivatives are among the oldest drugs approved for the treatment of the IBD. In this review we reapprise aspects of 5-ASA mechanism of action, safety, and efficacy that in our opinion make it a valuable drug that can be fruitfully tailored in personalised treatments as a therapeutic option alongside other immune-modifying agents.
authors: Unit of Clinical Pharmacology, National Research Council-Institute of Neuroscience, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy.
authors: Cristiana
authors: C
authors: Perrotta
authors: Unit of Clinical Pharmacology, National Research Council-Institute of Neuroscience, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy.
authors: Paolo
authors: P
authors: Pellegrino
authors: Unit of General Surgery, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy.
authors: Eliana
authors: E
authors: Moroni
authors: Unit of Clinical Pharmacology, National Research Council-Institute of Neuroscience, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy.
authors: Clara
authors: C
authors: De Palma
authors: Unit of Clinical Pharmacology, National Research Council-Institute of Neuroscience, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy ; Department for Innovation in Biological, Agro-Food and Forest Systems, Università della Tuscia, 01100 Viterbo, Italy.
authors: Davide
authors: D
authors: Cervia
authors: Unit of General Surgery, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy.
authors: Piergiorgio
authors: P
authors: Danelli
authors: Unit of Clinical Pharmacology, National Research Council-Institute of Neuroscience, Department of Biomedical and Clinical Sciences "Luigi Sacco", University Hospital "Luigi Sacco", Università di Milano, 20157 Milan, Italy ; Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
authors: Emilio
authors: E
authors: Clementi