title: Ventilator-associated events prevention, learning lessons from the past: A systematic review.
abstract: BACKGROUND
  Preventing Ventilator-associated events (VAE) is a major challenge. Strictly monitoring for ventilator-associated pneumonia (VAP) is not sufficient to ensure positive outcomes. Therefore, the surveillance definition was updated and a change to the broader VAE was advocated.
  
  
  OBJECTIVE
  This paper summarizes the scientific efforts assessing VAP preventive bundles and the recent transition in surveillance methods.
  
  
  METHODS
  We conducted a systematic review to identify lessons from past clinical studies assessing VAP prevention bundles. We then performed a thorough literature review on the recent VAE surveillance algorithm, highlighting its advantages and limitations.
  
  
  CONCLUSIONS
  VAP prevention bundles have historically proven their efficacy and the introduction of the new VAE definition aimed at refining and objectivizing surveillance methods. Randomized controlled trials remain vital to determine the effect of VAE prevention on patient outcomes. We recommend expanding beyond limited VAP prevention strategies towards VAE prevention bundles.
authors: Jad
authors: J
authors: Chahoud
authors: Department of Management, Policy and Community Health, School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
authors: Adele
authors: A
authors: Semaan
authors: Department of Internal Medicine, School of Medicine, University of Texas Health Science Center, Houston, TX, USA; Transplant Surgery ICU, Memorial Hermann Hospital TMC, Houston, TX, USA. Electronic address: Khalid.F.Almoosa@uth.tmc.edu.
authors: Khalid F
authors: KF
authors: Almoosa
mesh_terms: D006801:Humans; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012122:Ventilators, Mechanical / Q000009:adverse effects*
keywords: Bundles; Critical care; Prevention; Surveillance; Ventilator-associated Events; Ventilator-associated pneumonia