title: High prevalence of respiratory muscle weakness in hospitalized acute heart failure elderly patients.
abstract: BACKGROUND
  Respiratory Muscle Weakness (RMW) has been defined when the maximum inspiratory pressure (MIP) is lower than 70% of the predictive value. The prevalence of RMW in chronic heart failure patients is 30 to 50%. So far there are no studies on the prevalence of RMW in acute heart failure (AHF) patients.
  
  
  OBJECTIVE
  Evaluate the prevalence of RMW in patients admitted because of AHF and the condition of respiratory muscle strength on discharge from the hospital.
  
  
  METHODS
  Sixty-three patients had their MIP measured on two occasions: at the beginning of the hospital stay, after they had reached respiratory, hemodynamic and clinical stability and before discharge from the hospital. The apparatus and technique to measure MIP were adapted because of age-related limitations of the patients. Data on cardiac ejection fraction, ECG, brain natriuretic peptide (BNP) levels and on the use of noninvasive ventilation (NIV) were collected.
  
  
  RESULTS
  The mean age of the 63 patients under study was 75 years. On admission the mean ejection fraction was 33% (95% CI: 31-35) and the BNP hormone median value was 726.5 pg/ml (range: 217 to 2283 pg/ml); 65% of the patients used NIV. The median value of MIP measured after clinical stabilization was -52.7 cmH2O (range: -20 to -120 cmH2O); 76% of the patients had MIP values below 70% of the predictive value. On discharge, after a median hospital stay of 11 days, the median MIP was -53.5 cmH2O (range:-20 to -150 cmH2O); 71% of the patients maintained their MIP values below 70% of the predictive value. The differences found were not statistically significant.
  
  
  CONCLUSIONS
  Elderly patients admitted with AHF may present a high prevalence of RMW on admission; this condition may be maintained at similar levels on discharge in a large percentage of these patients, even after clinical stabilization of the heart condition.
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Pedro
authors: P
authors: Verissimo
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Thaisa Juliana André
authors: TJ
authors: Casalaspo
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Louise Helena Rodrigues
authors: LH
authors: Gonçalves
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Angela Shu Yun
authors: AS
authors: Yang
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Raquel Caserta
authors: RC
authors: Eid
authors: Intensive Care Unit and Coronary Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: Karina T
authors: KT
authors: Timenetsky
mesh_terms: D000208:Acute Disease; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000628:therapy*; D006760:Hospitalization; D006801:Humans; D001239:Inhalation; D008297:Male; D018908:Muscle Weakness / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012132:Respiratory Muscles / Q000503:physiopathology*