title: Pain regulation by nocistatin-targeting molecules: G protein-coupled-receptor and nocistatin-interacting protein.
abstract: Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are neuropeptides produced from the same precursor protein. N/OFQ is involved in a broad range of central functions including pain, learning, memory, anxiety, and feeding. However, NST has opposite effects on various central functions evoked by N/OFQ. The regulation of their receptors may be important for these opposite functions of NST and N/OFQ. Although N/OFQ binds to a specific N/OFQ receptor, the target molecule of NST remains unclear. Some biological effects of NST are mediated by a G protein-coupled receptor. Furthermore, using high-performance affinity nanobeads, we recently identified a 4-nitrophenylphosphatase domain and nonneuronal SNAP25-like protein homolog 1 (NIPSNAP1) as a protein that interacts with NST in the mouse spinal cord. The inhibition of N/OFQ-evoked tactile pain allodynia by NST is mediated by NIPSNAP1. This review focuses on the molecular mechanisms of pain regulation by the target molecules of NST including a G protein-coupled receptor and NIPSNAP1.
authors: Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan. Electronic address: ashitaka@bme.oit.ac.jp.
authors: Emiko
authors: E
authors: Okuda-Ashitaka
authors: Department of Medical Chemistry, Kansai Medical University, Hirakata, Japan.
authors: Seiji
authors: S
authors: Ito
mesh_terms: D000818:Animals; D015507:Drugs, Investigational / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D009292:Narcotic Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018847:Opioid Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D011506:Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011957:Receptors, Opioid / Q000819:agonists / Q000737:chemistry / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D015507:Drugs, Investigational; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; C113197:NIPSNAP1 protein, human; D009292:Narcotic Antagonists; D009419:Nerve Tissue Proteins; D018847:Opioid Peptides; D011506:Proteins; D011957:Receptors, Opioid; C111148:nocistatin; D043802:GTP-Binding Protein alpha Subunits, Gq-G11
keywords: G protein-coupled receptor; NIPSNAP1; Nociceptin/orphanin FQ; Nocistatin; Nocistatin-interacting protein; Pain