title: New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review.
abstract: Pain is an unpleasant sensory and emotional experience that is commonly associated with actual or potential tissue damage. Despite decades of pain research, many patients continue to suffer from chronic pain that is refractory to current treatments. Accumulating evidence has indicated an important role of protease-activated receptor 4 (PAR4) in the pathogenesis of inflammation and neuropathic pain. Here we reviewed PAR4 expression and activation via intracellular signaling pathways and the role of PAR4 signaling pathways in the development and maintenance of pain. Understanding PAR4 and its corresponding signaling pathways will provide insight to further explore the molecular basis of pain, which will also help to identify new targets for pharmacological intervention for pain relief.
authors: a Department of Oncology ; Guang'anmen Hospital ; China Academy of Chinese Medical Sciences; Beixiange 5 ; Xicheng District , Beijing , P. R. China.
authors: Yanju
authors: Y
authors: Bao
authors: Yebo
authors: Y
authors: Gao
authors: Liping
authors: L
authors: Yang
authors: Xiangying
authors: X
authors: Kong
authors: Honggang
authors: H
authors: Zheng
authors: Wei
authors: W
authors: Hou
authors: Baojin
authors: B
authors: Hua
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009437:Neuralgia / Q000378:metabolism*; D018179:Receptors, Thrombin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018179:Receptors, Thrombin; C112908:protease-activated receptor 4
keywords: inflammation pain; neuropathic pain; protease-activated receptor 4