title: CD8+ T-cells count in acute myocardial infarction in HIV disease in a predominantly male cohort.
abstract: Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (>1065 cells/mm3) had increased AMI risk (adjusted HR=1.82, P<0.001, 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8+ T-cell tertiles on AMI risk differed by CD4+ T-cell level: compared to uninfected people, HIV-infected people with CD4+ T-cell counts≥200 cells/mm3 had increased AMI risk with high CD8+ T-cell count, while those with CD4+ T-cell counts<200 cells/mm3 had increased AMI risk with low CD8+ T-cell count. CD8+ T-cell counts may add additional AMI risk stratification information beyond that provided by CD4+ T-cell counts alone.
authors: Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA.
authors: Oluwatosin A
authors: 0000-0002-9498-7947
authors: OA
authors: Badejo
authors: Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA ; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
authors: Chung-Chou
authors: CC
authors: Chang
authors: Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
authors: Kaku A
authors: KA
authors: So-Armah
authors: University of Vermont, Burlington, VT 05446, USA.
authors: Russell P
authors: 0000-0002-0080-2420
authors: RP
authors: Tracy
authors: Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN 55415, USA.
authors: Jason V
authors: JV
authors: Baker
authors: VA Medical Center, Emory University School of Medicine, Atlanta, GA 30033, USA.
authors: David
authors: 0000-0002-1885-9601
authors: D
authors: Rimland
authors: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA ; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA ; Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors: Adeel A
authors: AA
authors: Butt
authors: Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA ; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
authors: Adam J
authors: AJ
authors: Gordon
authors: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA ; Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
authors: Charles R
authors: CR
authors: Rinaldo
authors: Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA.
authors: Kevin
authors: 0000-0003-4937-0283
authors: K
authors: Kraemer
authors: Clinical Addiction Research and Education Unit, Boston University School of Medicine, Boston, MA 02118, USA ; Boston University School of Public Health, Boston, MA 02118, USA.
authors: Jeffrey H
authors: JH
authors: Samet
authors: Department of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
authors: Hilary A
authors: HA
authors: Tindle
authors: Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA ; Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
authors: Matthew B
authors: MB
authors: Goetz
authors: Michael E. DeBakey VA Medical Center, Infectious Diseases Section, Baylor College of Medicine, Houston, TX 77030, USA.
authors: Maria C
authors: MC
authors: Rodriguez-Barradas
authors: VA North Texas Healthcare System, Dallas, TX 75216, USA ; Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Roger
authors: R
authors: Bedimo
authors: Washington DC VA Medical Center, Washington, DC 20422, USA ; George Washington University Medical Center, Washington, DC 20037, USA.
authors: Cynthia L
authors: CL
authors: Gibert
authors: Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA ; Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
authors: David A
authors: 0000-0001-9052-3427
authors: DA
authors: Leaf
authors: Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
authors: Lewis H
authors: LH
authors: Kuller
authors: Department of Medicine, University of California, San Francisco, CA 94143, USA.
authors: Steven G
authors: SG
authors: Deeks
authors: Veteran Affairs Connecticut Health Care System, West Haven Veterans Administration Medical Center, Yale School of Medicine, Yale University, New Haven, CT 06516, USA.
authors: Amy C
authors: AC
authors: Justice
authors: Cardiovascular Medicine Division, Vanderbilt University Medical Center, 2525 West End, Suite 300-A, Nashville, TN 37203, USA.
authors: Matthew S
authors: MS
authors: Freiberg
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D014728:Veterans / Q000706:statistics & numerical data