title: Clinically relevant depressive symptoms in young stroke patients - results of the sifap1 study.
abstract: BACKGROUND
  Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort.
  
  
  METHODS
  The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patients with a cerebrovascular event aged 18-55. For assessing clinically relevant depressive symptoms (CRDS, defined by a BDI-score ≥18) the self-reporting Beck Depression Inventory (BDI) was obtained on inclusion in the study. Associations with baseline parameters, stroke severity (National Institutes of Health Stroke Scale, NIHSS), and brain MRI findings were analyzed.
  
  
  RESULTS
  From the 2007 patients with BDI documentation, 202 (10.1%) had CRDS. CRDS were observed more frequently in women (12.6 vs. 8.2% in men, p < 0.001). Patients with CRDS more often had arterial hypertension, diabetes mellitus, and hyperlipidemia than patients without CRDS (hypertension: 58.0 vs. 47.1%, p = 0.017; diabetes mellitus: 17.9 vs. 8.9%, p < 0.001; hyperlipidemia: 40.5 vs. 32.3%, p = 0.012). In the subgroup of patients with ischemic stroke or TIA (n = 1,832) no significant associations between CRDS and cerebral MRI findings such as the presence of acute infarcts (68.1 vs. 65.8%, p = 0.666), old infarctions (63.4 vs. 62.1%, p = 0.725) or white matter hyper-intensities (51.6 vs. 53.7%, p = 0.520) were found.
  
  
  CONCLUSIONS
  Depressive symptoms were present in 10.1% of young stroke patients in the acute phase, and were related to risk factors but not to imaging findings.
authors: Neurology, Justus Liebig University, Giessen, Germany.
authors: Christian
authors: C
authors: Tanislav
authors: Peter
authors: P
authors: Kropp
authors: Ulrike
authors: U
authors: Grittner
authors: Martin
authors: M
authors: Holzhausen
authors: Franz
authors: F
authors: Fazekas
authors: Gerhard Jan
authors: GJ
authors: Jungehülsing
authors: Turgut
authors: T
authors: Tatlisumak
authors: Bettina
authors: B
authors: von Sarnowski
authors: Jukka
authors: J
authors: Putaala
authors: Roman
authors: R
authors: Huber
authors: Vincent
authors: V
authors: Thijs
authors: Reinhold
authors: R
authors: Schmidt
authors: Manfred
authors: M
authors: Kaps
authors: Christian
authors: C
authors: Enzinger
authors: Martin
authors: M
authors: Dichgans
authors: Bo
authors: B
authors: Norrving
authors: Arndt
authors: A
authors: Rolfs
mesh_terms: D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D003863:Depression / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D055815:Young Adult