title: The Influences of Whole Brain Radiotherapy on Social Cognition and Association with Hippocampal and Frontal Dosimetry.
abstract: The influence of brain radiotherapy on neurocognition is a major concern. Social cognition is a mental process in the meaning of social interaction and the recognition of facial emotion is a domain of social cognition. Thus, we aimed to investigate the early effect of whole brain radiotherapy on facial emotion recognition ability. Thirteen patients with various brain tumors in the study. Beck depression and anxiety inventory and the facial emotion recognition test by using a set of photographs were performed at the beginning and post radiotherapy. The severity of depression (16.40 ± 12.16 vs 04.00 ± 02.38 points) and anxiety (14.47 ± 11.96 vs 04.54 ± 03.30 points) were significantly higher in patients. The only significance according to facial emotion recognition rate between initial phase of patients and healthy controls was identifying neutral facial em otion (p = 0.002). The patients after brain radiotherapy had significantly better rate of recognizing fear facial emotions (p = 0.039). This study is the first that investigated the effects of cranial irradiation on facial emotion recognition ability and compares this ability with healthy controls. Interestingly, in the early phase the patients seem to be improved in fear facial emotion after brain radiotherapy without sparing cognition specific regions as hippocampus and frontal regions.
authors: Department of Psychiatry, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. drerhanyuksek@gmail.com.
authors: Erhan
authors: E
authors: Yuksek
authors: Department of Psychiatry, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. sedaeroz@hotmail.com.|Department of Radiation Oncology, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. sedaeroz@hotmail.com.
authors: Seda
authors: S
authors: Eroz
authors: Department of Psychiatry, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. ahmetyassa@hotmail.com.
authors: Ahmet
authors: A
authors: Yassa
authors: Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. dilaraakturk@hotmail.com.
authors: Dilara
authors: D
authors: Akturk
authors: Department of Psychiatry, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. faganzakirov@gmail.com.
authors: Fagan
authors: F
authors: Zakirov
authors: Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. fenginakcam@hotmail.com.
authors: Funda Engin
authors: FE
authors: Akcam
authors: Department of Psychiatry, Medical School of Cerrahpasa, İstanbul University, Istanbul, Turkey. hmuratemul@hotmail.com.
authors: Murat
authors: M
authors: Emul
mesh_terms: D001932:Brain Neoplasms; D016371:Cranial Irradiation; D004307:Dose-Response Relationship, Radiation; D004644:Emotions; D005149:Facial Expression; D005260:Female; D005625:Frontal Lobe; D006624:Hippocampus; D006801:Humans; D017567:Karnofsky Performance Status; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D021641:Recognition, Psychology; D012919:Social Behavior; D018709:Statistics, Nonparametric; D015898:Tomography Scanners, X-Ray Computed
keywords: Brain radiotherapy; Cognition; Facial emotion recognition; Hippocampus