title: Opioids for chronic noncancer pain: still no evidence for superiority of sustained-release opioids.
abstract: Opioids are controversial in the treatment of chronic pain due to the risk of addiction, misuse, and death. Long-acting formulations of opioids have been hypothesized to improve pain relief, sleep quality, and lower the risk of side effects and addiction compared to short-acting formulations of opioids. Thus, several guidelines have recommended the use of long-acting opioid formulations over short-acting ones in the treatment of chronic noncancer pain. However, is there really evidence of their superiority?
authors: National Competence Centre for Complex Symptom Disorders, Trondheim, Norway; Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Internal Medicine, Sørlandet Hospital Kristiansand, Kristiansand, Norway.
authors: L
authors: L
authors: Pedersen
authors: Oms
authors: O
authors: Fredheim
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations