title: [Intrathecal baclofen therapy for hereditary spastic paraplegia].
abstract: Intrathecal baclofen therapy (ITB) is an established treatment for intractable spasticity. More than 1,100 patients have undergone ITB in Japan, and there are about 50 hereditary spastic paraplegia (HSP) The features of ITB in HSP are 1. small doses of baclofen may often be enough, 2. small changes of doses later the symptoms remarkably, 3. doses can be decreased after long term ITB.
authors: Department of Neurosurgery, Tokyo Women's Medical University.
authors: Takaomi
authors: T
authors: Taira
authors: Nobuhiko
authors: N
authors: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D001418:Baclofen / Q000008:administration & dosage*; D057785:Catheters / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D058786:GABA-B Receptor Agonists / Q000008:administration & dosage*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D058786:GABA-B Receptor Agonists; D001418:Baclofen