title: Self-perceived, but not objective lymphoedema is associated with decreased long-term health-related quality of life after breast cancer surgery.
abstract: BACKGROUND
  The primary aim was to compare long-term health-related quality of life (HRQoL) in patients undergoing sentinel lymph node biopsy (SLNB) alone versus axillary lymph node dissection (ALND), with or without axillary metastases. Secondary aims were to a) investigate agreement between objectively measured and self-reported lymphoedema and b) compare, with respect to HRQoL, women with objective arm lymphoedema without subjective ratings and those with no objective but subjective ratings of arm lymphoedema.
  
  
  METHODS
  The three study groups were defined by axillary surgery: 1) SLNB alone (N = 140), 2) ALND in patients without axillary metastases (N = 125) and 3) ALND in patients with axillary metastases (N = 155). Preoperatively, one and three years postoperatively arm volume was measured and questionnaires regarding self-perceived symptoms of arm lymphoedema and HRQoL were completed (The Swedish Short Form-36 Health Survey, SF-36).
  
  
  RESULTS
  Out of the original 516 who had axillary surgery, 420 (81%) completed the study. There were no statistically significant differences in HRQoL between the three study groups. No statistically significant agreement was found between self-perceived and objectively measured arm lymphoedema. Women without self-perceived arm lymphoedema, regardless of objective arm lymphoedema or not, scored higher on all eight SF-36 domains than those who reported self-perceived arm lymphoedema.
  
  
  CONCLUSIONS
  Women reporting self-perceived arm lymphoedema, regardless of objective lymphoedema or not, have a decreased long-term health-related quality of life. This indicates that more attention should be given to the subjective reports of symptom in order to better help these women.
authors: Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address: helena.ikonomidis-sackey@karolinska.se.
authors: H
authors: H
authors: Sackey
authors: Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors: H
authors: H
authors: Johansson
authors: Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors: K
authors: K
authors: Sandelin
authors: Department of Surgery, Örebro University Hospital, Örebro, Sweden.
authors: Göran
authors: G
authors: Liljegren
authors: Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors: G
authors: G
authors: MacLean
authors: Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors: J
authors: J
authors: Frisell
authors: Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors: Y
authors: Y
authors: Brandberg
mesh_terms: D000368:Aged; D001132:Arm / Q000473:pathology*; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D008207:Lymphatic Metastasis; D008209:Lymphedema / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D008875:Middle Aged; D009929:Organ Size; D010465:Perception; D011788:Quality of Life; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D013997:Time Factors
keywords: Arm lymphoedema; Axillary lymph node dissection; Breast cancer; Health-related quality of life; Self-perceived symptoms; Sentinel lymph node biopsy