title: OASL-a new player in controlling antiviral innate immunity.
abstract: The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
authors: Cancer Virology Program, University of Pittsburgh Cancer Institute, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
authors: Jianzhong
authors: J
authors: Zhu
authors: Cancer Virology Program, University of Pittsburgh Cancer Institute, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
authors: Arundhati
authors: A
authors: Ghosh
authors: Cancer Virology Program, University of Pittsburgh Cancer Institute, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address: saumen@pitt.edu.
authors: Saumendra N
authors: SN
authors: Sarkar
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*; D056704:Adaptive Immunity; D000818:Animals; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology* / Q000628:therapy / Q000821:virology; D014780:Viruses / Q000276:immunology* / Q000472:pathogenicity*
chemical_list: D051192:Receptors, Pattern Recognition; D014764:Viral Proteins; C115020:OASL protein, human; D015088:2',5'-Oligoadenylate Synthetase