title: [Behavior of high- and low-anxiety rats after modulation of GABAergic transmission in basolateral amygdala].
abstract: The influence of GABA(A) receptor agonist (muscimol hydrobromide, 0.1 μg/0.5 μL) and antagonist (bicuculline methiodide, 0.2 μg/0.5 μL) injections into the right and the left basolateral amygdala on the behavior of the high- and low-anxiety rats was investigated in elevated plus-maze test. High- and low-anxiety rats had different sensitivities to injections of GABA receptor agents. Administration of muscimol increased open-arm time only in the high-anxiety rats, indicating anxiolytic-like effect. Injection of bicuculline increased aggression of all rats, as well as enhanced locomotion and exploration in high-anxiety rats, increased open-arm time and emotionality in the low-anxiety animals. More powerful changes in behavior of rats were revealed after injections of muscimol into the left amygdala of high-anxiety rats and bicuculline into the right amygdala of low-anxiety ones. The results evidence the existence of individual typological and interhemispheric differences in functioning of the amygdalar GABAergic system.
authors: M P
authors: MP
authors: Rysakova
authors: I V
authors: IV
authors: Pavlova
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000378:metabolism* / Q000503:physiopathology; D066272:Basolateral Nuclear Complex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D007839:Functional Laterality; D018755:GABA Agonists / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018755:GABA Agonists; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D009118:Muscimol; C017069:bicuculline methiodide; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline