title: Dissecting the mechanisms of the clock in Neurospora.
abstract: The circadian clock exists to synchronize inner physiology with the external world, allowing life to anticipate and adapt to the continual changes that occur in an organism's environment. The clock architecture is highly conserved, present in almost all major branches of life. Within eukaryotes, the filamentous fungus Neurospora crassa has consistently been used as an excellent model organism to uncover the basic circadian physiology and molecular biology. The Neurospora model has elucidated our fundamental understanding of the clock as nested positive and negative feedback loop, regulated by transcriptional and posttranscriptional processes. This review will examine the basics of circadian rhythms in the model filamentous fungus N. crassa as well as highlight the output of the clock in Neurospora and the reasons that N. crassa has continued to be a strong model for the study of circadian rhythms. It will also synopsize classical and emerging methods in the study of the circadian clock.
authors: Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
authors: Jennifer
authors: J
authors: Hurley
authors: Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
authors: Jennifer J
authors: JJ
authors: Loros
authors: Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. Electronic address: Jay.C.Dunlap@Dartmouth.edu.
authors: Jay C
authors: JC
authors: Dunlap
mesh_terms: D057906:Circadian Clocks; D002940:Circadian Rhythm; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D015966:Gene Expression Regulation, Fungal; D009492:Neurospora crassa / Q000502:physiology*; D011499:Protein Processing, Post-Translational
chemical_list: D005656:Fungal Proteins
keywords: Circadian; Frequency; Molecular clock; Neurospora crassa; Output; White Collar Complex