title: Diagnostic value of contrast-enhanced ultrasound of thyroid nodules coexisting with Hashimoto's thyroiditis.
abstract: OBJECTIVE
  To evaluate the value of contrast-enhanced ultrasound (CEUS) in diagnosing thyroid nodules coexisting with Hashimoto's thyroiditis (HT).
  
  
  METHODS
  Totally 62 thyroid nodules in 48 HT patients were retrospectively analyzed. The CEUS characteristics were reviewed, and diagnostic value of enhancement pattern and peak intensity were calculated.
  
  
  RESULTS
  Peak intensity (P=0.002) and enhancement pattern (P<0.001) differed significantly between malignant and benign thyroid nodules. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of heterogeneous enhancement were 97.6%, 85.7%, 93.0%, 94.7%, and 93.5%, respectively. Sensitivity, specificity, PPV, NPV and accuracy of low intensity at peak time were 85.4%, 52.4%, 77.8%, 64.7%, and 74.2%, respectively.
  
  
  CONCLUSIONS
  Heterogeneous enhancement is effective in the diagnosis of malignant thyroid nodules coexisting with HT. CEUS can improve the diagnostic accuracy in distinguishing thyroid nodules with unknown malignancy under the conventional ultrasound.
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Rui-na
authors: RN
authors: Zhao
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Bo
authors: B
authors: Zhang
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Xiao
authors: X
authors: Yang
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Yu-xin
authors: YX
authors: Jiang
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Xing-jian
authors: XJ
authors: Lai
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Shen-ling
authors: SL
authors: Zhu
authors: Department of Ultrasound, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Xiao-yan
authors: XY
authors: Zhang
mesh_terms: D003287:Contrast Media; D050031:Hashimoto Disease; D006801:Humans; D016606:Thyroid Nodule / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media