title: Theoretical estimation of retinal oxygenation in chronic diabetic retinopathy.
abstract: This paper uses computer modeling to estimate the progressive decline in oxygenation that occurs in the human diabetic retina after years of slowly progressive ischemic insult. An established model combines diffusion, saturable consumption, and blood capillary sources to determine the oxygen distribution across the retina. Incorporating long-term degradation of blood supply from the retinal capillaries into the model yields insight into the effects of progressive ischemia associated with prolonged hyperglycemia, suggesting time-scales over which therapeutic mitigation could have beneficial effect. A new extension of the model for oxygen distribution introduces a feedback mechanism for vasodilation and its potential to prolong healthy retinal function.
authors: University of Colorado Denver, Rocky Mountain Lions Eye Institute, Aurora, CO, USA; University of Colorado Denver, Department of Ophthalmology, Denver, CO, USA.
authors: Jeffrey L
authors: JL
authors: Olson
authors: University of Colorado Denver, Department of Physics, Denver, CO, USA.
authors: Masoud
authors: M
authors: Asadi-Zeydabadi
authors: University of Colorado Denver, Department of Physics, Denver, CO, USA. Electronic address: randall.tagg@ucdenver.edu.
authors: Randall
authors: R
authors: Tagg
mesh_terms: D003198:Computer Simulation; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D012160:Retina / Q000737:chemistry*; D012171:Retinal Vessels / Q000503:physiopathology*
chemical_list: D010100:Oxygen
keywords: Computer model; Diabetes mellitus; Progressive ischemia; Retinopathy; Vasodilation