title: Cognitive impairment after chemotherapy related to atypical network architecture for executive control.
abstract: OBJECTIVE
  A common complaint of cancer patients is the experience of cognitive difficulty during and after chemotherapy. We hypothesized that cognitive impairment may result from dysfunction in large-scale brain networks, particularly those involved in attentional control.
  
  
  METHODS
  Using a case-control design, this study includes women with a history of invasive ductal or lobular triple-negative breast cancer who completed standard adjuvant chemotherapy within 2 years of study entry. Women who reported cognitive impairment by the Global Rating of Cognition question were considered to be cases (n = 15). Women who reported no cognitive impairment were considered to be controls (n = 13). All enrolled participants were eligible for MRI investigation and underwent resting-state functional connectivity MRI.
  
  
  RESULTS
  Women who self-reported cognitive impairment were found to have disrupted resting-state functional connectivity, as measured by MRI, when compared to women who did not self-report cognitive impairment. These findings suggest that some women may be more sensitive to the standard treatments for breast cancer and that this increased sensitivity may result in functional connectivity alterations in the brain networks supporting attention and executive function.
  
  
  CONCLUSIONS
  Neuroimaging analyses confirmed self-reported cognitive deficits in women with breast cancer treated with chemotherapy.
authors: Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, St. Louis, Mo., USA.
authors: Jay F
authors: JF
authors: Piccirillo
authors: Frances Mei
authors: FM
authors: Hardin
authors: Joyce
authors: J
authors: Nicklaus
authors: Dorina
authors: D
authors: Kallogjeri
authors: Michael
authors: M
authors: Wilson
authors: Cynthia X
authors: CX
authors: Ma
authors: Rebecca S
authors: RS
authors: Coalson
authors: Joshua
authors: J
authors: Shimony
authors: Bradley L
authors: BL
authors: Schlaggar
mesh_terms: D000368:Aged; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D018275:Carcinoma, Lobular / Q000188:drug therapy; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced* / Q000503:physiopathology*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D011788:Quality of Life; D057566:Self Report; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy