title: Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism.
abstract: Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (
  C) and recurrent VTE yielded inconclusive results. We studied these associations in patients diagnosed with acute pulmonary embolism. Plasma levels of MP-TF and FVIII activity were measured in 277 patients with a first and 72 patients with a recurrent VTE. All patients were categorized based on the quintiles of MP-TF and FVIII activity in those with a single VTE. For both markers, odds ratios (ORs) for recurrent VTE were computed using patients in the lowest quintile as a reference group. No association was observed between MP-TF activity and recurrent VTE, with an OR of 1.4 (95 % CI 0.7-2.9) in the highest quintile of MP-TF activity. Compared with the reference group, patients in the highest quintile of
  C were at increased risk of recurrent VTE, OR 4.2 (95 % CI 1.4-12.2). MP-TF activity was not associated with recurrent VTE whereas high
  C levels were associated with a 4-fold increased risk of VTE recurrence. Future prospective studies are necessary to explore the potential of
  C as a tool for risk stratification, either by itself or in combination with other pro-thrombotic markers.
authors: Department of Thrombosis and Haemostasis, Leiden University Medical Center, C7-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands, j.kooiman@lumc.nl.
authors: Judith
authors: J
authors: Kooiman
authors: Paul L
authors: PL
authors: den Exter
authors: Inci
authors: I
authors: Kilicsoy
authors: Suzanne C
authors: SC
authors: Cannegieter
authors: Jeroen
authors: J
authors: Eikenboom
authors: Menno V
authors: MV
authors: Huisman
authors: Frederikus A
authors: FA
authors: Klok
authors: Henri H
authors: HH
authors: Versteeg
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood* / Q000150:complications; D013925:Thromboplastin / Q000378:metabolism*; D054556:Venous Thromboembolism / Q000097:blood* / Q000150:complications
chemical_list: C078147:F8 protein, human; D005169:Factor VIII; D013925:Thromboplastin