title: Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding.
abstract: Dicycloplatin is a new generation supramolecular platinum-containing anti-cancer drug. Due to its structure, it is difficult to differentiate dicycloplatin from physical mixtures of carboplatin and cyclobutane dicarboxylate, and confounding results may arise during drug characterization. To solve this problem, this study aims to provide a reliable and reproducible standard for the determination of dicycloplatin. A simple method for dicycloplatin quality control has been developed using X-ray powder diffraction (XRPD) and high performance liquid chromatography (HPLC). XRPD allowed the control of impurities and dissociation of the dicycloplatin active ingredient to less than 1%, and HPLC allowed the monitoring and control of the relative molar ratio of carboplatin and cyclobutane dicarboxylate within the purity range. The study proved for the first time that the dicycloplatin supramolecule is substantially different from a physical mixture of carboplatin and cyclobutane dicarboxylate.
authors: College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors: Xuqing
authors: X
authors: Yang
authors: Jianwei
authors: J
authors: Zheng
authors: Qinghua
authors: Q
authors: Song
authors: Fang
authors: F
authors: Xie
authors: Jijun
authors: J
authors: Tang
authors: Jia
authors: J
authors: Chen
authors: Jianfeng
authors: J
authors: Wu
authors: Chunzheng
authors: C
authors: Li
authors: Weichuan
authors: W
authors: Cui
authors: Youqi
authors: Y
authors: Tang
authors: Jianwei
authors: J
authors: Xie
authors: Jianqiang
authors: J
authors: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004338:Drug Combinations; D005971:Glutamates / Q000032:analysis* / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000032:analysis* / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D005971:Glutamates; D009944:Organoplatinum Compounds; C580746:diammine(1,1-cyclobutanedicarboxylate)platinum(II)