title: Hedgehog signaling and steroidogenesis.
abstract: Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta. New evidence links the evolutionarily conserved Hh pathway to the steroidogenic organs, demonstrating how Hh signaling can influence their development and homeostasis and can act in concert with steroids to mediate physiological functions. In this review, we highlight the role of the components of the Hh signaling pathway in steroidogenesis of endocrine tissues.
authors: Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109; email: ifinco@med.umich.edu , lapensee@med.umich.edu , ghammer@med.umich.edu.
authors: Isabella
authors: I
authors: Finco
authors: Christopher R
authors: CR
authors: LaPensee
authors: Kenneth T
authors: KT
authors: Krill
authors: Gary D
authors: GD
authors: Hammer
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D005260:Female; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D008297:Male; D010053:Ovary / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology*; D013256:Steroids / Q000378:metabolism*; D013737:Testis / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D013256:Steroids
keywords: Sf1; adrenal; ovary; placenta; steroids; testis