title: Novel or non-vitamin K antagonist oral anticoagulants and the treatment of cancer-associated thrombosis.
abstract: Cancer-associated thrombosis remains a common and challenging clinical presentation. Despite advances in therapy using low-molecular-weight heparins, both venous thromboembolic recurrence and clinically relevant bleeding while on therapeutic anticoagulation occur at high rates. Multiple novel (or non-vitamin K antagonist) oral anticoagulants have recently been developed for the treatment and prevention of venous thromboembolism. There are many attractive features of these agents including convenience and simplicity of administration. Unfortunately, there are also several limitations such as dependency on gastrointestinal absorption, renal clearance, and some significant drug-drug interactions. The use of these newer oral agents in cancer patients is not recommended, as their safety and efficacy are not yet established and the complexity of these patients warrants further cancer-specific clinical trials.
authors: Division of Hematology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors: Cynthia
authors: C
authors: Wu
authors: Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Agnes Y Y
authors: AY
authors: Lee
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D054556:Venous Thromboembolism / Q000378:metabolism / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D014812:Vitamin K