title: Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors.
abstract: Human D-type prostanoid (DP) and E-type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and found that EP2 receptors have 8-fold fewer amino acid mutations. We speculate that EP2 receptors exhibit more constraints to mutations than DP receptors.
authors: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors: Jun
authors: J
authors: Tanimoto
authors: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: fujino@chiba-u.jp.
authors: Hiromichi
authors: H
authors: Fujino
authors: Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan. Electronic address: hiroki.takahashi@chiba-u.jp.
authors: Hiroki
authors: H
authors: Takahashi
authors: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
authors: Toshihiko
authors: T
authors: Murayama
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D011982:Receptors, Prostaglandin / Q000235:genetics*; D058307:Receptors, Prostaglandin E, EP2 Subtype / Q000235:genetics*
chemical_list: C545644:PTGER2 protein, human; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D058307:Receptors, Prostaglandin E, EP2 Subtype; C036293:prostaglandin D2 receptor
keywords: DP receptor; EP2 receptor; Prostaglandin D(2); Prostaglandin E(2); Prostanoid receptor; Tandem duplication