title: Clinical assessment and C-reactive protein (CRP), haptoglobin (Hp), and cardiac troponin I (cTnI) values of brachycephalic dogs with upper airway obstruction before and after surgery.
abstract: Brachycephalic dogs have unique upper respiratory anatomy with abnormal breathing patterns that are similar to those in humans with obstructive sleep apnea syndrome (OSAS). The objectives of this multicenter prospective study were to assess the effects of surgical correction on clinical signs in dogs with brachycephalic airway obstructive syndrome (BAOS) and to evaluate the levels of several biomarkers [C-reactive protein (CRP); haptoglobin (Hp), and cardiac troponin I (cTnI)] used to determine systemic inflammation and myocardial damage. This study was conducted on 33 dogs with BAOS that were evaluated before and 1 to 2 mo after surgical correction. Palatoplasty was carried out by means of 2 different surgical techniques: carbon dioxide (CO2) laser (n = 12) and electrical scalpel (n = 21). Biomarker levels (CRP, Hp, and cTnI) were determined before and after surgery. There was a significant reduction in respiratory and gastrointestinal signs in dogs with BAOS after surgical treatment (P < 0.001). A greater reduction in respiratory signs (P < 0.002) was obtained using the CO2 laser. No statistical differences were found between CRP and cTnI levels, either before or after surgical correction. Haptoglobin concentration did increase significantly in the postsurgical period (P < 0.008). Surgical treatment in dogs with BAOS reduces clinical signs, regardless of the anatomical components present. Surgical treatment for BAOS is not useful to reduce CRP and Hp levels, probably because BAOS does not induce as obvious an inflammatory process in dogs as in human patients with OSAS. No reduction in cTnI levels was observed 1 mo after surgery in dogs with BAOS, which suggests that some degree of myocardial damage remains.
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Marta
authors: M
authors: Planellas
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Rafaela
authors: R
authors: Cuenca
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Maria-Dolores
authors: MD
authors: Tabar
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Coralie
authors: C
authors: Bertolani
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Cyrill
authors: C
authors: Poncet
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Josep M
authors: JM
authors: Closa
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Juan
authors: J
authors: Lorente
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: José J
authors: JJ
authors: Cerón
authors: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès (08193), Barcelona, Spain (Planellas, Cuenca, Pastor); Centro Policlínico Veterinario Raspeig, Camí del Rodalet str. 17, San Vicente del Raspeig (03690), Alicante, Spain (Tabar); Centre Hospitalier Vétérinaire Frégis, Avenue Aristide Briand 43, Arcueil (94110), France (Bertolani, Poncet); Hospital ARS Veterinaria, Cardedeu str. 3, Barcelona (08023), Spain (Closa); Otolaryngology Service, Hospital General Universitari de la Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona (08035), Spain (Lorente); Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain (Cerón).
authors: Josep
authors: J
authors: Pastor
mesh_terms: D000402:Airway Obstruction / Q000097:blood / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D003398:Craniosynostoses / Q000097:blood / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000601:surgery*; D004285:Dogs; D004564:Electrocoagulation; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D054020:Lasers, Gas / Q000627:therapeutic use; D008297:Male; D010160:Palate, Soft / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods / Q000662:veterinary; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D006242:Haptoglobins; D019210:Troponin I; D002097:C-Reactive Protein