title: Nasopharyngeal carcinoma mimicking Aspergillosis rhinosinusitis: an unusual case report and review of the literature.
abstract: Clinical symptoms and imaging features of fungal infection are confused with those of atypical nasopharyngeal carcinoma (NPC), and therefore development of a more effective diagnostic method is essential. It is a common knowledge that there is a significant association between Epstein-Barr virus (EBV) and nonkeratinizing NPC. However, fungal infection may be considered to be a vital etiologic agent contributing to the NPC and more evidence is needed to be approved this theory. We report on a rare case of a patient with atypical nasopharyngeal carcinoma (NPC) who suffered from chronic fungal infection and was diagnosed initially as Aspergillosis. Following anti-aspergillus infection therapy, the repeated deep biopsy of the maxillary sinus and MRI confirmed the diagnosis of nasopharyngeal carcinoma (NPC).
authors: Department of Oncology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Kexing
authors: K
authors: Ren
authors: Department of Pathology, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Weiya
authors: W
authors: Wang
authors: Department of Oncology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Xuelei
authors: X
authors: Ma
authors: Department of Oncology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Fuchun
authors: F
authors: Guo
authors: Department of Oncology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Ping
authors: P
authors: Li
authors: Department of Oncology and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University Chengdu, China.
authors: Lei
authors: L
authors: Liu
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D001706:Biopsy; D002277:Carcinoma; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012220:Rhinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D012852:Sinusitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents
keywords: Aspergillosis; Nasopharyngeal carcinoma; atypical symptom; diagnosis; fungal infection; pathogenic factor