title: Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel.
abstract: Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no efficacious treatment that will control the seizures and improve the cognitive decline in this disease. We report a patient with Lafora disease who experienced a dramatic amelioration in her seizure frequency as well as the associated neurological and cognitive dysfunction following initiation of treatment with perampanel administered as monotherapy. Perampanel is the first potentially efficacious treatment for Lafora disease. We discuss a potential mechanism for the efficacy of perampanel in this disease.
authors: Division of Pediatric Neurology, American University of Beirut Medical Center, Lebanon.
authors: Maya
authors: M
authors: Dirani
authors: Department of Neurology, American University of Beirut Medical Center, Lebanon.
authors: Wassim
authors: W
authors: Nasreddine
authors: Department of Clinical Neurosciences, Salmaniya Medical Complex, Bahrain.
authors: Fatima
authors: F
authors: Abdulla
authors: Department of Neurology, American University of Beirut Medical Center, Lebanon.
authors: Ahmad
authors: A
authors: Beydoun
keywords: Anticonvulsants; Lafora disease; Perampanel; Progressive myoclonic epilepsy