title: [New therapeutic approaches to pulmonary embolism: trials' results and significance of direct oral anticoagulants].
abstract: Venous thromboembolisms (VTE) are frequently encountered emergencies that sometimes run a fatal course. Diagnostic and therapeutic strategies in patients with suspected pulmonary embolism (PE) are based on the presence of shock and hypotension. Oral anticoagulation is recommended for at least three months, extended anticoagulation should be considered for patients with unprovoked PE and low bleeding risk. As an alternative to vitamin K antagonists, direct oral anticoagulants are recommended. The present review discusses the mode of action, current data, and the status of rivaroxaban, dabigatran, apixaban and edoxaban in the treatment of PE - taking into account the new guidelines of the European Society of Cardiology and their clinical implementation.
authors: Medizinische Klinik und Poliklinik II - Innere Medizin mit den Schwerpunkten Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Bonn.
authors: C
authors: C
authors: Pizarro
authors: Medizinische Klinik und Poliklinik II - Innere Medizin mit den Schwerpunkten Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Bonn.
authors: C
authors: C
authors: Hammerstingl
authors: Medizinische Klinik und Poliklinik II - Innere Medizin mit den Schwerpunkten Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Bonn.
authors: C
authors: C
authors: Schaefer
authors: Klinik für Pneumologie, Evangelische Lungenklinik Berlin.
authors: C
authors: C
authors: Grohé
authors: Medizinische Klinik und Poliklinik II - Innere Medizin mit den Schwerpunkten Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Bonn.
authors: G
authors: G
authors: Nickenig
authors: Medizinische Klinik und Poliklinik II - Innere Medizin mit den Schwerpunkten Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Bonn.
authors: D
authors: D
authors: Skowasch
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D002309:Cardiology / Q000592:standards; D004334:Drug Administration Schedule; D005060:Europe; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic; D011655:Pulmonary Embolism / Q000188:drug therapy*; D015272:Pulmonary Medicine / Q000592:standards; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants