title: Manganese doped iron oxide theranostic nanoparticles for combined T1 magnetic resonance imaging and photothermal therapy.
abstract: Photothermal therapy (PTT) is a noninvasive and convenient way to ablate tumor tissues. Integrating PTT with imaging technique could precisely identify the location and the size of tumor regions, thereby significantly improving the therapeutic efficacy. Magnetic resonance imaging (MRI) is widely used in clinical diagnosis due to its superb spatial resolution and real-time monitoring feature. In our work, we developed a theranostic nanoplatform based on manganese doped iron oxide (MnIO) nanoparticles modified with denatured bovine serum albumin (MnIO-dBSA). The in vitro experiment revealed that the MnIO nanoparticles exhibited T1-weighted MRI capability (r1 = 8.24 mM(-1) s(-1), r2/r1 = 2.18) and good photothermal effect under near-infrared laser irradiation (808 nm). Using 4T1 tumor-bearing mice as an animal model, we further demonstrated that the MnIO-dBSA composites could significantly increase T1 MRI signal intensity at the tumor site (about two times) and effectively ablate tumor tissues with photoirradiation. Taken together, this work demonstrates the great potential of the MnIO nanoparticles as an ideal theranostic platform for efficient tumor MR imaging and photothermal therapy.
authors: Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123, China.
authors: Mengxin
authors: M
authors: Zhang
authors: Yuhua
authors: Y
authors: Cao
authors: Lina
authors: L
authors: Wang
authors: Yufei
authors: Y
authors: Ma
authors: Xiaolong
authors: X
authors: Tu
authors: Zhijun
authors: Z
authors: Zhang
mesh_terms: D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D010789:Phototherapy; D011859:Radiography; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D000068936:Theranostic Nanomedicine; D014184:Transplantation, Homologous
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D012710:Serum Albumin, Bovine; D008345:Manganese
keywords: MR imaging; magnetic nanoparticles; photothermal therapy; theranostics