title: Novel Ti-base superelastic alloys with large recovery strain and excellent biocompatibility.
abstract: In this study, a new Ti-Zr-Nb-Sn alloy system was developed as Ni-free biomedical superelastic alloys with a large recovery strain and excellent biocompatibility. Ti-18Zr-(9-16)Nb-(0-4)Sn alloys were prepared by an Ar arc melting method and the effect of composition on the crystal structure and superelastic properties was investigated. A large superelastic recovery strain of 6.0% was observed in Ti-18Zr-12.5Nb-2Sn, Ti-18Zr-11Nb-3Sn, and Ti-18Zr-9.5Nb-4Sn alloys subjected to cold-rolling and solution treatment. XRD results showed that the large recovery strain of Sn-added alloys is due to a combination effect of a large transformation strain and a strong recrystallization texture. The Ti-18Zr-11Nb-3Sn alloy exhibited excellent cyclic stability with an extremely narrow stress hysteresis about 20MPa. Cytocompatibility was also examined using three types of cell lines, murine fibroblast L929, human osteosarcoma SaOS-2, and human umbilical vein endothelial cell HUVEC and the results showed that the Ti-18Zr-11Nb-3Sn alloy exhibited larger cell covering ratios when compared with those of the Ti-50.5Ni alloy for all kinds of cells.
authors: Division of Materials Science, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan.
authors: Jie
authors: J
authors: Fu
authors: Biomaterials Unit, International Center for Material Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan.
authors: Akiko
authors: A
authors: Yamamoto
authors: Division of Materials Science, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan. Electronic address: heeykim@ims.tsukuba.ac.jp.
authors: Hee Young
authors: HY
authors: Kim
authors: Precision and Intelligence Laboratory, Tokyo Institute of Technology, Yokohama 226-8503, Japan.
authors: Hideki
authors: H
authors: Hosoda
authors: Division of Materials Science, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan. Electronic address: miyazaki@ims.tsukuba.ac.jp.
authors: Shuichi
authors: S
authors: Miyazaki
mesh_terms: D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D003470:Culture Media / Q000737:chemistry; D004548:Elasticity; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008422:Materials Testing; D051379:Mice; D009532:Nickel / Q000737:chemistry*; D009556:Niobium / Q000737:chemistry*; D011312:Pressure; D013314:Stress, Mechanical; D013324:Strontium / Q000737:chemistry*; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D003470:Culture Media; D009556:Niobium; D009532:Nickel; D014025:Titanium; D015032:Zinc; D013324:Strontium
keywords: Recovery strain; Recrystallization texture; Superelasticity; Ti alloys