title: Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries.
abstract: The aging population is increasing dramatically. Aging-associated stress simultaneously drives proinflammatory remodeling, involving angiotensin II and other factors, in both the heart and large arteries. The structural remodeling and functional changes that occur with aging include cardiac and vascular wall stiffening, systolic hypertension and suboptimal ventricular-arterial coupling, features that are often clinically silent and thus termed a silent syndrome. These age-related effects are the result of responses initiated by cardiovascular proinflammatory cells. Local proinflammatory signals are coupled between the heart and arteries due to common mechanical and humoral messengers within a closed circulating system. Thus, targeting proinflammatory signaling molecules would be a promising approach to improve age-associated suboptimal ventricular-arterial coupling, a major predisposing factor for the pathogenesis of clinical cardiovascular events such as heart failure.
authors: Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), 251 Bayview Blvd, Baltimore, MD 21224, USA. Electronic address: mingyiw@grc.nia.nih.gov.
authors: Mingyi
authors: M
authors: Wang
authors: Cardiovascular Division, King's College London British Heart Foundation Centre of Excellence, London, UK. Electronic address: ajay.shah@kcl.ac.uk.
authors: Ajay M
authors: AM
authors: Shah
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001158:Arteries / Q000378:metabolism* / Q000473:pathology; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation; D016023:Integrins / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016023:Integrins; D015850:Interleukin-6; D035683:MicroRNAs; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Aging; Cardiovascular remodeling; Proinflammation; Ventricular–arterial coupling