title: Pathogen manipulation of B cells: the best defence is a good offence.
abstract: B cells have long been regarded as simple antibody production units, but are now becoming known as key players in both adaptive and innate immune responses. However, several bacteria, viruses and parasites have evolved the ability to manipulate B cell functions to modulate immune responses. Pathogens can affect B cells indirectly, by attacking innate immune cells and altering the cytokine environment, and can also target B cells directly, impairing B cell-mediated immune responses. In this Review, we provide a summary of recent advances in elucidating direct B cell-pathogen interactions and highlight how targeting this specific cell population benefits different pathogens.
authors: 1] Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France. [2] INSERM U1202, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France. [3] Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
authors: Katharina
authors: K
authors: Nothelfer
authors: 1] Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France. [2] INSERM U1202, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France. [3] Collège de France, Chaire de Microbiologie et Maladies Infectieuses, 75005 Paris, France.
authors: Philippe J
authors: PJ
authors: Sansonetti
authors: 1] Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France. [2] INSERM U1202, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris, CEDEX 15, France.
authors: Armelle
authors: A
authors: Phalipon
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D001419:Bacteria / Q000276:immunology; D018407:Bacterial Physiological Phenomena; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D010271:Parasites / Q000276:immunology / Q000502:physiology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000276:immunology