title: Proliferation and apoptosis of Peyer's patches and its lymphocytes in experimental terminal ileitis.
abstract: This study will provide guide for the terminal ileitis in clinical diagnosis and treatment. The animals were been done terminal ileum-cecum side to side anastomosis, terminal ileum operation line and only anesthesia treatment, respectively. The model group presented acute inflammation after surgery for 2 weeks and the inflammation was limited to the mucosal layer. Animals presented chronic inflammation to 8 weeks, mucosal membrane was given priority to with lymphocytic infiltrates. In 2 weeks and 4 weeks, the number of Peyer's patches (PP knot) and PP knot lymphocytes increased significantly in the model group (P < 0.05, P < 0.01). At 8 weeks, the suture group and the model group presented a large number of lymphocytic apoptosis (P < 0.01). Rat ileal PP knot lymphocyte small molecule DNA showed typical "trapezoid" bands. We observed apparent morphology of apoptosis and crescent-shaped nucleus. Continuous immune response in terminal ileitis plays a considerable role in the process of the disease.
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Wei
authors: W
authors: Wang
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Ailei
authors: A
authors: Xu
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Guohua
authors: G
authors: Zhou
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Mingfang
authors: M
authors: Leng
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Hongyu
authors: H
authors: Zhou
authors: Department of Gastroenterology, Affiliated Xiangnan Hospital of Hunan Normal University 169 Hospital of PLA, Hengyang, P.R. China.
authors: Jun
authors: J
authors: Yan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D049109:Cell Proliferation; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D010581:Peyer's Patches / Q000276:immunology / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Cell apoptosis; PP knot; lymphocytes; terminal ileitis