title: Peroxisome-mitochondria interplay and disease.
abstract: Peroxisomes and mitochondria are ubiquitous, highly dynamic organelles with an oxidative type of metabolism in eukaryotic cells. Over the years, substantial evidence has been provided that peroxisomes and mitochondria exhibit a close functional interplay which impacts on human health and development. The so-called "peroxisome-mitochondria connection" includes metabolic cooperation in the degradation of fatty acids, a redox-sensitive relationship, an overlap in key components of the membrane fission machineries and cooperation in anti-viral signalling and defence. Furthermore, combined peroxisome-mitochondria disorders with defects in organelle division have been revealed. In this review, we present the latest progress in the emerging field of peroxisomal and mitochondrial interplay in mammals with a particular emphasis on cooperative fatty acid β-oxidation, redox interplay, organelle dynamics, cooperation in anti-viral signalling and the resulting implications for disease.
authors: College of Life and Environmental Sciences, Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK, m.schrader@exeter.ac.uk.
authors: Michael
authors: M
authors: Schrader
authors: Joseph
authors: J
authors: Costello
authors: Luis F
authors: LF
authors: Godinho
authors: Markus
authors: M
authors: Islinger
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D010084:Oxidation-Reduction; D018901:Peroxisomal Disorders / Q000235:genetics / Q000378:metabolism; D020675:Peroxisomes / Q000378:metabolism*; D014777:Virus Diseases / Q000378:metabolism
chemical_list: D005227:Fatty Acids