title: Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis.
abstract: OBJECTIVE
  To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness.
  
  
  METHODS
  A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry.
  
  
  RESULTS
  The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera.
  
  
  CONCLUSIONS
  This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future.
authors: Luohu Center for Disease Control and Prevention, Department of Public Health, Shenzhen, China.
authors: Jie
authors: J
authors: You
authors: Luohu Center for Disease Control and Prevention, Department of Chemical Laboratory, Shenzhen, China.
authors: YaJun
authors: Y
authors: Yue
authors: Leizhou Center for Disease Control and Prevention, Department of Public Health, Leizhou, China.
authors: Feng
authors: F
authors: Xing
authors: Luohu Center for Disease Control and Prevention, Department of Public Health, Shenzhen, China.
authors: Wei
authors: W
authors: Xia
authors: Luohu Center for Disease Control and Prevention, Department of Chemical Laboratory, Shenzhen, China.
authors: ShaoYang
authors: S
authors: Lai
authors: Luohu Center for Disease Control and Prevention, Department of Public Health, Shenzhen, China.
authors: FengLei
authors: F
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002681:China / Q000453:epidemiology; D002853:Chromatography, Liquid; D004196:Disease Outbreaks; D005260:Female; D005400:Fishes, Poisonous; D005517:Foodborne Diseases / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010473:Perciformes; D012189:Retrospective Studies; D053719:Tandem Mass Spectrometry; D013779:Tetrodotoxin / Q000097:blood / Q000506:poisoning*
chemical_list: D013779:Tetrodotoxin