title: Postnatal lung function in congenital cystic adenomatoid malformation of the lung.
abstract: BACKGROUND
  Management of prenatally diagnosed but postnatal asymptomatic pulmonary lesions remains controversial. The aim of this study was to investigate the effect of congenital cystic adenomatoid malformation of the lung (CCAM) on postnatal lung function tests (LFT) and to elucidate whether LFTs help identify infants who would benefit from early surgery.
  
  
  METHODS
  The LFTs were performed in 26 CCAM infants at a median (interquartile range) postmenstrual age of 42.4 (39.6 to 44.0) weeks and compared with LFT from 30 healthy controls. The LFT included the measurement of tidal breathing, functional residual capacity by body plethysmography, respiratory mechanics (respiratory compliance), and respiratory resistance by occlusion test and blood gas analysis.
  
  
  RESULTS
  The CCAM infants showed a restrictive ventilation disorder with increased respiratory rates (p = 0.006) and marginally decreased tidal volumes (p = 0.043). Furthermore, respiratory compliance was significantly reduced as compared with controls (p < 0.001). No statistically significant differences were seen in the respiratory resistance, functional residual capacity, and capillary blood gases. Particularly in CCAM infants who had surgery in the first 2 years of life, a marked reduction of respiratory compliance (p < 0.001) was seen preoperatively.
  
  
  CONCLUSIONS
  Congenital cystic adenomatoid malformation can cause restrictive ventilation disorders, which can be detected and monitored by postnatal LFT. Thus, LFT represents an additional tool to support the decision for or against surgical intervention.
authors: Department of Neonatology, Charité University Medical Centre, Berlin, Germany. Electronic address: payman.barikbin@charite.de.
authors: Payman
authors: P
authors: Barikbin
authors: Department of Neonatology, Charité University Medical Centre, Berlin, Germany.
authors: Charles Christoph
authors: CC
authors: Roehr
authors: Department of Neonatology, Charité University Medical Centre, Berlin, Germany.
authors: Silke
authors: S
authors: Wilitzki
authors: Department of Obstetrics, Charité University Medical Centre, Berlin, Germany.
authors: Karim
authors: K
authors: Kalache
authors: Department of Paediatric Surgery, Charité University Medical Centre, Berlin, Germany.
authors: Petra
authors: P
authors: Degenhardt
authors: Department of Neonatology, Charité University Medical Centre, Berlin, Germany.
authors: Christoph
authors: C
authors: Bührer
authors: Department of Neonatology, Charité University Medical Centre, Berlin, Germany.
authors: Gerd
authors: G
authors: Schmalisch
mesh_terms: D001784:Blood Gas Analysis; D016022:Case-Control Studies; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D012016:Reference Values; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013990:Tidal Volume