title: What every doctor should know about drug safety in patients with chronic kidney disease.
abstract: Drug safety is a very relevant issue when dealing with patients with chronic kidney disease (CKD) who need vascular access procedures and interventions. Drug dosage adjustments are needed for patients with acute or chronic kidney disease. In CKD patients, the estimated glomerular filtration rate is used to guide dose adjustments. Determining the influence of renal replacement therapies on drug dosage adjustment is also very important. Safety issues for the following drugs used for situations related to vascular access are reported: anticoagulants and antiplatelet agents, antibiotics, antimicrobials for catheter lock therapy, thrombolytics, local anesthetics, and painkillers. General principles of the interactions of drugs in CKD are also reported.
authors: Nephrology and Dialysis Unit, Ospedale San Carlo Borromeo, Milan, Italy.
authors: Maria
authors: M
authors: Paparella
authors: Valentina
authors: V
authors: Martina
authors: Maria Antonietta
authors: MA
authors: Rizzo
authors: Maurizio
authors: M
authors: Gallieni
mesh_terms: D000700:Analgesics / Q000493:pharmacokinetics; D000779:Anesthetics, Local / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D000925:Anticoagulants / Q000493:pharmacokinetics; D054796:Drug Dosage Calculations; D004347:Drug Interactions; D005343:Fibrinolytic Agents / Q000493:pharmacokinetics; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D061214:Patient Safety; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology / Q000628:therapy*; D062666:Vascular Access Devices
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D005343:Fibrinolytic Agents