title: Regulation of Ca(2+) transient by PP2A in normal and failing heart.
abstract: Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.
authors: Department of Pharmacology, University of Oxford Oxford, UK.
authors: Ming
authors: M
authors: Lei
authors: Faculty of Life Science, University of Manchester Manchester, UK.
authors: Xin
authors: X
authors: Wang
authors: Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago Chicago, IL, USA.
authors: Yunbo
authors: Y
authors: Ke
authors: Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago Chicago, IL, USA.
authors: R John
authors: RJ
authors: Solaro
keywords: FTY720; arrhythmia; calcium handling; heart failure; ion channels; phosphatase