title: Association of ANCA associated vasculitis and rheumatoid arthritis: a lesser recognized overlap syndrome.
abstract: BACKGROUND
  ANCA associated vasculitis (AAV) is an autoimmune disease with significant morbidity and mortality, in which diagnostic delay is associated with worse outcomes. AAV is rarely found in association with other immune mediated diseases. Early recognition of such overlaps enables more timely diagnosis and may impact on disease outcome. We reviewed cases of AAV in which there was an overlap with rheumatoid arthritis (RA).
  
  
  METHODS
  We performed a retrospective analysis of our vasculitis database for patients who had a diagnosis of AAV and RA, and a literature search to find other reported cases of this overlap syndrome.
  
  
  RESULTS
  We found six subjects who had a diagnosis of RA and developed AAV at a median of 10.5 years (range 4-43 years) after the diagnosis of RA. They had been treated with a mean of 2 disease modifying drugs (0-4) and all had evidence of renal involvement with median creatinine of 227 μmol/l (range 128-700 μmol/l). Only one had a diagnosis of granulomatosis with polyangiitis, while the rest had a clinical diagnosis of microscopic polyangiitis. Half of the patients had positive rheumatoid factor (RhF) at the time of vasculitis diagnosis, three had MPO-ANCA, one PR3-ANCA, and two had ANCA-negative pauci-immune vasculitis. Additionally, we found 29 other cases reported of this overlap, which also most frequently presented with vasculitic renal manifestations, and were frequently RhF positive at the time of AAV diagnosis.
  
  
  CONCLUSIONS
  AAV occurs in subjects with RA rarely, and often with significant delay from the first rheumatological manifestations. Renal involvement is common.
authors: Nephrology Department, Bellvitge University Hospital, Feixa llarga s/n 08097, Barcelona, Spain.
authors: Juliana
authors: J
authors: Draibe
authors: UCL Centre for Nephrology, Royal Free Hospital, London, NW3 2PF UK.
authors: Alan D
authors: AD
authors: Salama
keywords: ANCA associated vasculitis; Overlap syndromes; Rheumatoid arthritis