title: Chemotherapy-induced nausea and vomiting in Italian cancer centers: results of CINVDAY, a prospective, multicenter study.
abstract: OBJECTIVE
  Guideline consistency in the prevention of chemotherapy-induced nausea and vomiting (CINV) remains low (29% in the Pan European Emesis Registry study) and very low (11%) in regimens with a high emetogenic risk. The aim of this study was to evaluate the guideline consistency of CINV prophylaxis for acute emesis in daily clinical practice in Italy.
  
  
  METHODS
  This was a prospective, observational, multicenter study. Patients scheduled to receive antitumor treatment on a single prespecified day were included. Data on patient characteristics (demographic and clinical), type of anticancer therapy, and type of antiemetic therapy prescribed for acute emesis were collected on electronic data capture forms. Chemotherapy regimens and antiemetic prophylaxis were categorized according to the MASCC 2011 guidelines. The study was approved by the local ethics committees.
  
  
  RESULTS
  From July 2013 to February 2014, a total of 502 patients were enrolled at 26 study sites. Median age was 62 years (range 27-87 years). Colorectal cancer and breast cancer were the most common malignancies. The emetogenic potential of the chemotherapy regimens used was high (HEC) (23.7%), moderate (MEC) (40.6%), low (31.3%) or minimal (4.4%). Overall, guideline consistency was 19.3%. Consistency reached 45% when the various 5HT3 receptor antagonists were considered equivalent and interchangeable in MEC regimens. Adherence to guidelines was lowest for MEC and Minimal risk groups. Ten percent of patients in HEC and MEC regimens did not receive any 5HT3 receptor antagonists. NK1 receptor antagonists were used in 8% of all regimens.
  
  
  CONCLUSIONS
  Our study indicates that antiemetic guideline inconsistency remains an issue in daily clinical oncology practice in Italy.
authors: Michele
authors: M
authors: De Tursi
authors: Consiglia
authors: C
authors: Carella
authors: Silverio
authors: S
authors: Tomao
authors: Saverio
authors: S
authors: Cinieri
authors: Vito
authors: V
authors: Lorusso
authors: Paolo
authors: P
authors: Marchetti
authors: Stefania
authors: S
authors: Vecchio
authors: Elisabetta
authors: E
authors: Sansoni
authors: Antonio
authors: A
authors: Contu
authors: Vincenzo
authors: V
authors: Adamo
authors: Nicola
authors: N
authors: Silvestris
authors: Antonio
authors: A
authors: Nuzzo
authors: Giovanni
authors: G
authors: Rosti
authors: Alberto
authors: A
authors: Ravaioli
authors: Marco
authors: M
authors: Danova
authors: Giuseppe
authors: G
authors: Tonini
authors: Rodolfo
authors: R
authors: Passalacqua
authors: Giorgio
authors: G
authors: Cruciani
authors: Marina
authors: M
authors: Faedi
authors: Massimiliano
authors: M
authors: Spada
authors: Michelino
authors: M
authors: De Laurentiis
authors: Domenico
authors: D
authors: Amoroso
authors: Federica
authors: F
authors: Tomao
authors: Isabella
authors: I
authors: Sperduti
authors: Antonino
authors: A
authors: Grassadonia
authors: Nicola
authors: N
authors: Tinari
authors: Clara
authors: C
authors: Natoli
authors: Stefano
authors: S
authors: Iacobelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002173:Cancer Care Facilities; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy; D064729:Neurokinin-1 Receptor Antagonists / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D064729:Neurokinin-1 Receptor Antagonists; D058831:Serotonin 5-HT3 Receptor Antagonists