title: Absolute asymmetric synthesis: protected substrate oxidation.
abstract: Three new conglomerates incorporating bidentate sulfide ligands coordinated by Ru(II) centers have been prepared. Total spontaneous resolution by slow crystallization gives highly enantioenriched crystal batches, which are used in enantioselective oxidation of the sulfide ligands to give chiral sulfoxide complexes with >98 % ee. All relevant stereoisomers have been characterized by single-crystal X-ray diffraction, CD spectroscopy, and chiral HPLC. If the ligand range can be extended to monodentate sulfides, a large-scale and recyclable process for enantioselective oxidation of sulfides can be designed.
authors: Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96 Gothenburg (Sweden).
authors: Susanne
authors: S
authors: Olsson
authors: Per Martin
authors: PM
authors: Björemark
authors: Theonitsa
authors: T
authors: Kokoli
authors: Jonas
authors: J
authors: Sundberg
authors: Anders
authors: A
authors: Lennartson
authors: Christine J
authors: CJ
authors: McKenzie
authors: Mikael
authors: M
authors: Håkansson
keywords: asymmetric synthesis; crystal growth; oxidation; ruthenium; sulfur ligands