title: Immunohistochemical expression of dual-specificity protein phosphatase 4 in patients with colorectal adenocarcinoma.
abstract: The role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial. The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma. We constructed tissue microarrays and investigated DUSP4 expression by immunohistochemistry. DUSP4 was more frequently expressed in adenocarcinomas and lymph node/distant metastases compared to that in normal colorectal tissues and tubular adenomas (P < 0.001). Mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (P < 0.001). DUSP4 expression was significantly correlated with older age (P = 0.017), male gender (P = 0.036), larger tumor size (P = 0.014), nonmucinous tumor type (P = 0.023), and higher T stage (P = 0.040). Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on both overall survival and disease-free survival in AJCC stage I (P = 0.008 and P = 0.003, resp., log-rank test) and male gender (P = 0.017 and P = 0.049, resp., log-rank test). DUSP4 protein is frequently upregulated in colorectal adenocarcinoma and may play an important role in carcinogenesis and cancer progression and may be a marker of adverse prognosis.
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Jongmin
authors: J
authors: Sim
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Kijong
authors: K
authors: Yi
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Hyunsung
authors: H
authors: Kim
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Hyein
authors: H
authors: Ahn
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Yumin
authors: Y
authors: Chung
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Abdul
authors: A
authors: Rehman
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Se Min
authors: SM
authors: Jang
authors: Department of Surgery, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Kang Hong
authors: KH
authors: Lee
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Kiseok
authors: K
authors: Jang
authors: Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Republic of Korea.
authors: Seung Sam
authors: SS
authors: Paik