title: Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val¹⁵⁸met and fibromyalgia.
abstract: This study is to evaluate the association between the catechol-O-methyltransferase (COMT) gene val(158)met polymorphism and FM risk. We performed a meta-analysis of 8 case-control studies that included 589 FM cases and 527 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed that the COMT gene val(158)met polymorphism was not associated with FM risk in all genetic models, i.e., allele (met vs. val: OR=1.46, 95% CI=0.80-2.66, P heterpgeneity<0.001), homozygous (met/met vs. val/val: OR=1.72, 95% CI=0.61-4.87, P heterpgeneity<0.001), heterozygous (val/met vs. val/val: OR=1.25, 95% CI=0.82-1.92, P heterpgeneity=0.050), recessive (met/met vs. val/val+val/met: OR=1.52, 95% CI=0.60-3.86, P heterpgeneity<0.001) and dominant model (met/met+val/met vs. val/val: OR=1.52, 95% CI=0.80-2.90, P heterpgeneity<0.001). Similarly, there were no significant associations in the subgroup analyses by ethnicity and HWE. No publication bias was found in the present study. This meta-analysis suggests that the COMT gene val(158)met polymorphism is not associated with FM risk. Further large and well-designed studies are needed to confirm this association.
authors: Department of Orthopedics, Jinling Hospital, Nanjing University School of Medcine Nanjing, China.
authors: Lei
authors: L
authors: Zhang
authors: Department of Orthopedics, Jinling Hospital, Nanjing University School of Medcine Nanjing, China.
authors: Junwei
authors: J
authors: Zhu
authors: Department of Orthopedics, Jinling Hospital, Nanjing University School of Medcine Nanjing, China.
authors: Yong
authors: Y
authors: Chen
authors: Department of Orthopedics, Jinling Hospital, Nanjing University School of Medcine Nanjing, China.
authors: Jianning
authors: J
authors: Zhao
mesh_terms: D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005356:Fibromyalgia / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: Fibromyalgia; catechol-O-methyltransferase; meta-analysis; polymorphism