title: Acute Liver Failure and Hepatic Encephalopathy After Cleft Palate Repair.
abstract: Paracetamol is the most commonly used analgesic after cleft palate repair. It has rarely caused acute hepatic failure at therapeutic or supratherapeutic doses. Only one case of therapeutic paracetamol toxicity after cleft palate repair had been reported previously. Here, we present a similar patient who developed acute liver failure and hepatic encephalopathy after an uncomplicated cleft palate surgery. Lack of large prospective trials in young children due to ethical concerns increases the value of the case reports of acetaminophen toxicity at therapeutic doses. The dosing recommendations of paracetamol may need to be reconsidered after cleft palate surgery.
authors: Nihal Durmuş
authors: ND
authors: Kocaaslan
authors: Fatma Betul
authors: FB
authors: Tuncer
authors: Engin
authors: E
authors: Tutar
authors: Ozhan
authors: O
authors: Celebiler
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D002972:Cleft Palate / Q000601:surgery*; D006501:Hepatic Encephalopathy / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
keywords: acetaminophen toxicity; cleft palate; encephalopathy; liver failure; paracetamol