title: Effects of isoflurane on somatosensory-evoked potentials in calves: a pilot study.
abstract: Somatosensory evoked potentials (SSEP) are used to monitor sensory function and are often recorded under general anesthesia. The objective of the study was to evaluate the effects of isoflurane on SSEPs in calves as it has not been reported. Eight calves (mean age: 40 days), were included in the study. Calves were anesthetized with a randomized sequence of four different isoflurane partial pressures. Blood gas analysis was performed before each measurement. SSEP were induced by repeated stimulation of the common dorsal digital nerve III. SSEPs were recorded from the lumbo-sacral junction (s-SSEP) and the head (c-SSEP). Latency and inter-amplitude of each peak were measured. For s-SSEP: One negative (Nsp1) and two positive (Psp1 and Psp2) peaks were identified in all tracings except for two calves. There was a significant effect of isoflurane on the latency of Psp2 (P = 0.01). Inter-amplitude decreased significantly with PaO2, PaCO2 and temperature (P < 0.05). Psp2 latency decreased with PaO2 (P = 0.01). For c-SSEP: two positive (Pc1 and Pc2) and two negative (Nc1 and Nc2) peaks were identified. There were identifiable peaks for the analysis of Pc1 latencies only. There was a significant positive linear relation between end-tidal isoflurane partial pressure (ETiso) and Pc1 latency (P = 0.04). None of the co-variables had a significant effect on the latency of Pc1 (P > 0.1). Isoflurane has a major impact on the recording of c-SSEP. Recording should be done at the lowest ETiso as possible, and anesthesia parameters should be kept constant.
authors: Département de sciences cliniques, faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec.
authors: Geoffrey
authors: G
authors: Truchetti
authors: Département de sciences cliniques, faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec.
authors: Patrick
authors: P
authors: Burns
authors: Département de sciences cliniques, faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec.
authors: Sylvain
authors: S
authors: Nichols
authors: Département de sciences cliniques, faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec.
authors: Joane
authors: J
authors: Parent
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002417:Cattle / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D015233:Models, Statistical; D010865:Pilot Projects; D011897:Random Allocation
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane