title: Star-shaped PCL/PLLA blended fiber membrane via electrospinning.
abstract: Electrospun fiber mesh has been a candidate for guided bone regeneration membrane. However, its poor mechanics property has been limited in clinical application. In this study, various star-shaped poly(ε-caprolactones) (PCLs) are successfully synthesized by ring-opening polymerization and mixed with poly(l-lactide) (PLLA) to be made into blended membranes through electrospinning. Their corresponding properties are evaluated including morphology, thermodynamics, mechanics, and cytotoxicity. The blended fibers show smooth surface and well-distributed structure, which have slight differences in morphology with the change of arm number of star-shaped PCL. Crystallization of the fibrous membrane is influenced by star-shaped PCLs. Glass temperature drops from 64.23 °C for pure PLLA membrane to 53.62-49 °C for the blended membranes. The membranous tensile strength is depended strongly on star-shaped PCLs. The tensile strength goes up with arm number increasing; on the contrary, at the same arm number, the mechanics strength decreases with molecular weight increasing. And the fibrous membrane containing 20 wt.% star-shaped PCL shows better mechanics property compared to the other membranes. The star-shaped PCL/PLLA fiber membrane is not cytotoxicity.
authors: a School of Chemical Engineering , Changchun University of Technology , Changchun 130012 , P.R. China.
authors: Haotian
authors: H
authors: Li
authors: Tiankui
authors: T
authors: Qiao
authors: Ping
authors: P
authors: Song
authors: HuiLing
authors: H
authors: Guo
authors: Xiaofeng
authors: X
authors: Song
authors: Baochang
authors: B
authors: Zhang
authors: Xuesi
authors: X
authors: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation; D002478:Cells, Cultured; D055598:Chemical Phenomena; D055119:Elastic Modulus; D008422:Materials Testing; D055595:Mechanical Phenomena; D008567:Membranes, Artificial; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D010006:Osteoblasts / Q000166:cytology*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011091:Polyesters; C062968:lactide-caprolactone copolymer
keywords: PLLA; electrospun fiber membrane; mechanics property; star-shaped PCL