title: Hepatitis B virus compartmentalization in the cerebrospinal fluid of HIV-infected patients.
abstract: We detected hepatitis B virus (HBV) DNA in the cerebrospinal fluid (CSF) of 26 adolescents co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) with neurological disease and studied compartmentalization of HBV in the CSF. More than half of the subjects with positive HBV DNA plasma also had CSF positive for HBV. CSF HBV DNA was found in subjects with preserved blood-brain barrier integrity. In a subgroup of these subjects, compartmentalized evolution of HBV was demonstrated by distinct profiles of resistance mutations. Future studies are warranted to determine the clinical significance of HBV presence in the CSF and its contribution to HIV-associated neurological disease.
authors: HIV Department, "Dr. Victor Babes" Hospital for Infectious and Tropical Diseases, Bucharest, Romania.
authors: L
authors: L
authors: Ene
authors: HIV Department, "Dr. Victor Babes" Hospital for Infectious and Tropical Diseases, Bucharest, Romania.
authors: D
authors: D
authors: Duiculescu
authors: Virology Immunology and Molecular Biology Laboratory, "Dr. Victor Babes" Hospital for Infectious and Tropical Diseases, Bucharest, Romania.
authors: G
authors: G
authors: Tardei
authors: "Stefan S. Nicolau" Institute of Virology, Bucharest, Romania; Department of Virology "Carol Davila", University of Medicine and Pharmacy, Bucharest, Romania.
authors: S
authors: S
authors: Ruta
authors: University of California San Diego, CA, USA.
authors: D M
authors: DM
authors: Smith
authors: Department of Medicine, University of San Diego, University of California San Diego, CA, USA.
authors: S
authors: S
authors: Mehta
authors: Department of Medicine, University of San Diego, University of California San Diego, CA, USA.
authors: S
authors: S
authors: Letendre
authors: Departments of Psychiatry and Pathology, University of California San Diego, CA, USA.
authors: C L
authors: CL
authors: Achim
mesh_terms: D000293:Adolescent; D002555:Cerebrospinal Fluid / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: Cerebrospinal fluid; co-infection; compartmentalization; hepatitis B virus; human immunodeficiency virus