title: Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica.
abstract: The CXC chemokines (CXC-motif ligand 12 and CXC-motif ligand 14) and platelet-derived growth factor are suggested to modulate remyelination in the course of many demyelinating diseases. The present study compared the difference in the brain levels of these chemokines between patients with idiopathic demyelinating optic neuritis (IDON) and neuromyelitis optica (NMO) by measuring their concentrations in the cerebrospinal fluid using an enzyme linked immunosorbent assay. Our data indicate that the prognosis of neuritis depends on the remyelinating process that is impaired due to decreased chemokines. The much lower levels of chemokines would specifically indicate the severe neuritis, such as NMO.
authors: Department of Neuro-Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors: Chen
authors: C
authors: Tingjun
authors: Department of Neuro-Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors: Li
authors: L
authors: Zhaohui
authors: Department of Neuro-Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology, LongFu Hospital, Beijing, China.
authors: Jiang
authors: J
authors: Zhaocai
authors: Department of Neuro-Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology, Dongzhimen Hospital, Beijing, China.
authors: Liu
authors: L
authors: Zihao
authors: Department of Neurology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors: Xu
authors: X
authors: Quangang
authors: Department of Neurology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors: Huang
authors: H
authors: Dehui
authors: Department of Psychology, College of Science, The University of Texas at Arlington, Arlington, TX, USA. Electronic address: qilin@uta.edu.
authors: Lin
authors: L
authors: Qing
authors: Department of Neuro-Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address: weishihui1958@163.com.
authors: Wei
authors: W
authors: Shihui
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology; D054377:Chemokine CXCL12 / Q000134:cerebrospinal fluid*; D019743:Chemokines, CXC / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology*; D009460:Neurologic Examination; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid / Q000473:pathology*; D009902:Optic Neuritis / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000134:cerebrospinal fluid*; D012372:ROC Curve; D012720:Severity of Illness Index; D013577:Syndrome
chemical_list: C515255:CXCL12 protein, human; C118056:CXCL14 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D010982:Platelet-Derived Growth Factor
keywords: Biomarkers; CXC-motif ligand 12; CXC-motif ligand 14; Enzyme linked immunosorbent assay; Idiopathic demyelinating optic neuritis; Neuromyelitis optica; Platelet-derived growth factor