title: Association of VNTR polymorphisms in DRD4, 5-HTT and DAT1 genes with obesity.
abstract: OBJECTIVE
  To investigate the association between VNTR polymorphisms of DRD4, DAT1 and 5-HTT genes and obesity.
  
  
  METHODS
  Peripheral blood samples of 234 obese (BMI ≥ 30) and 148 healthy individuals (BMI ≤ 25) were objected to PCR to detect the VNTR of the 2nd intron of 5-HTT, 3rd exon of DRD4 and 3'UTR of DAT1 genes.
  
  
  RESULTS
  The association between obesity and genotype distributions of 5-HTT, DAT1 and DRD4 genes and between obesity and distributions of allele frequencies were tested by Chi Square (χ(2)) test and were not found statistically significant. BMI values for genotype of obese and morbidly obese (BMI > 40) individuals were analyzed by Kruskal-Wallis and not found statistically significant differences between BMI values for the most frequent genotypes of 5-HTT, DAT1 and DRD4 genes.
  
  
  CONCLUSIONS
  As a conclusion, there was no association between 5-HTT, DAT1 and DRD4 genes VNTR polymorphisms and obesity.
authors: Hacettepe University, Faculty of Science, Department of Biology, 06800, Beytepe , Ankara , Turkey and.
authors: Mustafa
authors: M
authors: Uzun
authors: Emel
authors: E
authors: Saglar
authors: Sibel
authors: S
authors: Kucukyildirim
authors: Beril
authors: B
authors: Erdem
authors: Hande
authors: H
authors: Unlu
authors: Hatice
authors: H
authors: Mergen
mesh_terms: D015992:Body Mass Index; D016022:Case-Control Studies; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D050638:Receptors, Dopamine D4
keywords: Dopamine D4 receptor gene; dopamine transporter gene; obesity; serotonin transporter gene; variable number tandem repeat polymorphism