title: CXCR3: latest evidence for the involvement of chemokine signaling in bone cancer pain.
abstract: Growing evidence indicates that chemokines participate in the generation and maintenance of bone cancer pain (BCP). Recent work in Exp Neurol by Guan et al. (2015) demonstrated the involvement of spinal chemokine receptor CXCR3 and its downstream PI3K/Akt and Raf/MEK/ERK signaling pathways in BCP. This work provides new evidence to support that chemokines participate in central sensitization in BCP condition. Reviewed evidence suggests that few chemokines have been proved to be related to cancer pain. The underlying relationship between CXCR3 signaling and BCP condition requires further study.
authors: Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan 430030, PR China.
authors: Genhua
authors: G
authors: Guo
authors: Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan 430030, PR China. Electronic address: gaofeng9261@hotmail.com.
authors: Feng
authors: F
authors: Gao
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D010146:Pain / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D054367:Receptors, CXCR3 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C515187:CXCR3 protein, human; D018925:Chemokines; D054367:Receptors, CXCR3
keywords: Akt; Bone cancer pain; CXCR3; Chemokine; Chronic pain; ERK