title: [Expression of apolipoprotein A-I in eight histological types of renal neoplasms].
abstract: OBJECTIVE
  To investigate the expression of apolipoprotein A-I(ApoA-I) in eight histological types of renal neoplasms and to explore a new biomarker for differential diagnosis.
  
  
  METHODS
  The immunochemistry was used to detect the expression of ApoA-I in 23 cases of renal tumors, including clear cell carcinoma,papillary cell carcinoma, chromophobe cell carcinoma, oncocytoma,multilocular cystic carcinoma, renal pelvis invasive urothelial carcinoma,metanephric adenoma and collecting ducts carcinoma. Five cases of cancer-adjacent normal tissues were obtained from another five renal tumor patients and were chosen as control group.
  
  
  RESULTS
  In the 23 cases of renal tumors, ApoA-I was expressed in 21 cases (positive rate was 91.3%). There were only two in five cases of normal tissues which expressed this protein (positive rate was 40.0%). A significant differentiation was observed between the two groups(Z=-2.829,P=0.003). In renal clear cell carcinoma (RCC), ApoA-I expression level was correlated with the grade and stage of tumor tissues. ApoA-I was stained much more stronger in RCC II-III than in RCC I (Z=-2.070,P=0.038).In various histological types of renal cancer, ApoA-I was all expressed to some degrees.
  
  
  CONCLUSIONS
  ApoA-I can be chosen as a tumor biomarker to differentiate various histological types of renal neoplasms.
authors: Department of Clinical Laboratory,The Ninth Clinical Medical College, Peking University, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038,China.
authors: Bei
authors: B
authors: Gong
authors: Department of Clinical Laboratory,The Ninth Clinical Medical College, Peking University, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038,China.
authors: Hui-hui
authors: HH
authors: Hu
authors: Department of Clinical Laboratory,The Ninth Clinical Medical College, Peking University, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038,China.
authors: Man
authors: M
authors: Zhang
mesh_terms: D018249:Adenoma, Oxyphilic / Q000378:metabolism; D016632:Apolipoprotein A-I / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D014408:Biomarkers, Tumor