title: ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.
abstract: This commentary highlights the article by Sisson et al, which establishes the importance of the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic target in the management of fibrotic lung disease.
authors: Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado; Department of Immunology, University of Colorado School of Medicine, Aurora, Colorado; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: richesd@njhealth.org.
authors: David W H
authors: DW
authors: Riches
authors: Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
authors: Donald S
authors: DS
authors: Backos
authors: Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
authors: Elizabeth F
authors: EF
authors: Redente
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology*; D008648:Mesoderm / Q000473:pathology*; D026362:Serum Response Factor / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D026362:Serum Response Factor; D015534:Trans-Activators