title: The vasorelaxant effect of p-cymene in rat aorta involves potassium channels.
abstract: The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigate the effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has a relaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using a nonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selective potassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating that BKCa and KV channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, KATP and Kir blockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxing effect on rat aorta, regardless of the endothelium, but with the participation of the KATP and Kir channels.
authors: Programa de Pós-Graduação em Recursos Naturais do Semiárido (PGRNSA), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Martapolyana T M
authors: MT
authors: Silva
authors: Programa de Pós-Graduação em Recursos Naturais do Semiárido (PGRNSA), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Fernanda P R A
authors: FP
authors: Ribeiro
authors: Programa de Pós-Graduação em Recursos Naturais do Semiárido (PGRNSA), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Maria Alice M B
authors: MA
authors: Medeiros
authors: Curso de Farmácia, Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Pedrita A
authors: PA
authors: Sampaio
authors: Curso de Farmácia, Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Yonara M S
authors: YM
authors: Silva
authors: Curso de Farmácia, Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Morganna T A
authors: MT
authors: Silva
authors: Centro de Ciências Biológicas e da Saúde, Departamento de Fisiologia, Universidade Federal de Sergipe, Campus de São Cristóvão, 49100-001 Aracaju, SE, Brazil.
authors: Jullyana S S
authors: JS
authors: Quintans
authors: Centro de Ciências Biológicas e da Saúde, Departamento de Fisiologia, Universidade Federal de Sergipe, Campus de São Cristóvão, 49100-001 Aracaju, SE, Brazil.
authors: Lucindo J
authors: LJ
authors: Quintans-Júnior
authors: Colegiado de Ciências Farmacêuticas (CFARM), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil.
authors: Luciano A A
authors: LA
authors: Ribeiro
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D000081007:Cymenes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D008297:Male; D039821:Monoterpenes / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D019789:Tetraethylammonium / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D000081007:Cymenes; D039821:Monoterpenes; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014665:Vasodilator Agents; C007210:4-cymene; D002586:Cesium; D010656:Phenylephrine; D019789:Tetraethylammonium; D015761:4-Aminopyridine; C028019:cesium chloride; D005905:Glyburide; D004121:Dimethyl Sulfoxide