title: Immunohistochemical expression of cytokeratins and epithelial membrane protein 2 in nasopharyngeal carcinoma and its potential implications.
abstract: BACKGROUND
  Nasopharyngeal carcinoma (NPC) is an aggressive disease and tends to involve surrounding tissues, and biomarkers for better management are yet to be identified.
  
  
  METHODS
  One hundred and fifty tissue samples with NPC diagnosis were were investigated using pan cytokeratin (CK) and epithelial membrane protein 2 (EMP2) antibodies.
  
  
  RESULTS
  Immunohistochemical expression of CK was identified in 144/150 (96%) and of EMP2 in 120/150 (80%).
  
  
  CONCLUSIONS
  There is a high loss of EMP2 in NPC, especially high grade examples. Loss of CK expression is also linked to high grade NPC types.
authors: Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia E-mail : hussaingad1972@yahoo.com.
authors: Hussain Gadelkarim
authors: HG
authors: Ahmed
authors: Rania Saad
authors: RS
authors: Abdul Gader Suliman
authors: Mohammed Siddig
authors: MS
authors: Abd El Aziz
authors: Fawaz D
authors: FD
authors: Alshammari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D060787:Neoplasm Grading; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C486403:EMP2 protein, human; D008562:Membrane Glycoproteins; D007633:Keratins