title: New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid.
abstract: Mono or di-substituted prolines, namely proline chimeras of natural or synthetic origin, carry the side chain of other specific amino acids on the pyrrolidine ring. Thus, proline chimeras are useful tools for a wide range of chemical and biological applications as chiral synthons or building blocks for peptidomimetic design. We focused our attention on domoic acid and kainic acid and we report here a concise and up to date review on their stereoselective and asymmetric syntheses.
authors: Dipartimento di Farmacia, Universita di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100, Chieti, Italy. a.mollica@unich.it.
authors: Adriano
authors: A
authors: Mollica
authors: Roberto
authors: R
authors: Costante
authors: Azzurra
authors: A
authors: Stefanucci
authors: Ettore
authors: E
authors: Novellino
mesh_terms: D002384:Catalysis; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D008958:Models, Molecular; D009498:Neurotoxins / Q000378:metabolism*
chemical_list: D009498:Neurotoxins; C012301:domoic acid; D007608:Kainic Acid