title: Regulation of energy homeostasis by the NPY system.
abstract: Obesity develops when energy intake exceeds energy expenditure over time. Numerous neurotransmitters, hormones, and factors have been implicated to coordinately control energy homeostasis, centrally and peripherally. However, the neuropeptide Y (NPY) system has emerged as the one with the most critical functions in this process. While NPY centrally promotes feeding and reduces energy expenditure, peptide YY (PYY) and pancreatic polypeptide (PP), the other family members, mediate satiety. Importantly, recent research has uncovered additional functions for these peptides that go beyond the simple feeding/satiety circuits and indicate a more extensive function in controlling energy homeostasis. In this review, we will discuss the actions of the NPY system in the regulation of energy balance, with a particular focus on energy expenditure.
authors: Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, 2010, Australia; Faculty of Medicine, UNSW Australia, Sydney, 2052, Australia.
authors: Kim
authors: K
authors: Loh
authors: Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, 2010, Australia; Faculty of Medicine, UNSW Australia, Sydney, 2052, Australia. Electronic address: h.herzog@garvan.org.au.
authors: Herbert
authors: H
authors: Herzog
authors: Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, 2010, Australia; Faculty of Medicine, UNSW Australia, Sydney, 2052, Australia. Electronic address: y.shi@garvan.org.au.
authors: Yan-Chuan
authors: YC
authors: Shi
mesh_terms: D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D019894:Peptide YY / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D019894:Peptide YY
keywords: energy expenditure; energy homeostasis; neuropeptide Y (NPY); pancreatic polypeptide (PP); peptide YY (PYY)