title: Prognostic value of ALDH1A3 promoter methylation in gliob;astoma: a single center experience in Western China.
abstract: BACKGROUND
  Aberrations in gene methylation patterns play important roles in gliomagenesis. However, whether the ALDH1A3 promoter methylation is related to prognoses of primary glioblastomas (GBMs) in Western China remains unclear.
  
  
  METHODS
  Methylation levels of ALDH1A3 CpG island in 36 GBMs were identified by pyrophosphate sequencing, while ALDH1A3 expression was assessed with matched paraffin section immunohistochemistry. Survival curves were analysed by Kaplan-Meier.
  
  
  RESULTS
  The hypermethylation status of ALDH1A3 promoter predicted a better prognosis accompanied with low expression of ALDH1A3 protein.
  
  
  CONCLUSIONS
  Our results indicate ALDH1A3 promoter methylation correlates with prognosis in primary GBMs.
authors: Neurosurgery Department of Yunnan Tumor Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, China E-mail : niweikm@163.com.
authors: Wei
authors: W
authors: Ni
authors: Lin
authors: L
authors: Luo
authors: Zuo
authors: Z
authors: Ping
authors: Hong-Ping
authors: HP
authors: Yuan
authors: Xu-Dong
authors: XD
authors: Zhao
authors: Wei
authors: W
authors: Xu
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002681:China; D003131:Combined Modality Therapy; D019175:DNA Methylation; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D015996:Survival Rate
chemical_list: D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+)