title: Acute interstitial nephritis due to statin and its class effect.
abstract: Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis. Atorvastatin was withdrawn and he was treated with corticosteroid following which renal function recovered. When he was rechallenged with rosuvastatin 6 months later following an episode of acute myocardial infarction, he developed AKI again indicating class effect of statin for nephrotoxicity.
authors: Department of Nephrology, Apollo Hospitals, Chennai, Tamil Nadu, India.
authors: R A
authors: RA
authors: Annigeri
authors: Department of Pathology, Apollo Hospitals, Chennai, Tamil Nadu, India.
authors: R M
authors: RM
authors: Mani
keywords: Acute interstitial nephritis; acute kidney injury; statins