title: Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.
abstract: HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-of-the-art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.
authors: Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France Université de Strasbourg, Strasbourg, France.
authors: Mirjam B
authors: MB
authors: Zeisel
authors: Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon, France.
authors: Julie
authors: J
authors: Lucifora
authors: Fox Chase Cancer Center, Philadelphia, USA.
authors: William S
authors: WS
authors: Mason
authors: INTS, Laboratoire de Virologie Moléculaire, Paris, France.
authors: Camille
authors: C
authors: Sureau
authors: Department of Internal Medicine 2/Molecular Biology, University Hospital Freiburg, Freiburg, Germany.
authors: Jürgen
authors: J
authors: Beck
authors: Center for Life Nanosciences (CNLS)-IIT/Sapienza, Rome, Italy Laboratory of Gene Expression, Department of Internal Medicine (DMISM), Sapienza University of Rome, Italy.
authors: Massimo
authors: M
authors: Levrero
authors: Université de Bordeaux, Microbiologie fondamentale et Pathogénicité, UMR 5234, Bordeaux, France CNRS, Microbiologie fondamentale et Pathogénicité, UMR 5234, Bordeaux, France CHU de Bordeaux, Bordeaux, France.
authors: Michael
authors: M
authors: Kann
authors: Technische Universität München, Institut für Molekulare Immunologie, München, Germany.
authors: Percy A
authors: PA
authors: Knolle
authors: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier, France.
authors: Monsef
authors: M
authors: Benkirane
authors: Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon, France.
authors: David
authors: D
authors: Durantel
authors: Laboratoire de Pathogenèse des Virus de l'Hépatite B, Département de Virologie, Institut Pasteur, Paris, France.
authors: Marie-Louise
authors: ML
authors: Michel
authors: Laboratory of Immunity and Infection, Inserm U945, Paris, France Laboratory of Immunity and Infection, UPMC University Paris 06, Unité mixte de recherche-S945, Paris, France Inserm, IFR 113, Immunité-Cancer-Infection, Paris, France.
authors: Brigitte
authors: B
authors: Autran
authors: CIRI-International Center for Infectiology Research, Team EVIR, Université de Lyon, Lyon, France. Inserm, U1111, Lyon, France Ecole Normale Supérieure de Lyon, Lyon, France. CNRS, UMR5308, Lyon, France LabEx Ecofect, Université de Lyon, Lyon, France.
authors: François-Loïc
authors: FL
authors: Cosset
authors: Innate Immunity Unit, Institut Pasteur, Inserm U668, Paris, France.
authors: Hélène
authors: H
authors: Strick-Marchand
authors: Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon, France Department of Hepatology, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France.
authors: Christian
authors: C
authors: Trépo
authors: Department of Internal Medicine, Department of Medical Research, Graduate Institute of Clinical Medicine, and Hepatitis Research Center, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
authors: Jia-Horng
authors: JH
authors: Kao
authors: Inserm, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France Sorbonne Universités, UPMC Univ Paris 06, Paris, France Assistance Publique Hôpitaux de Paris, Hôpital Saint Antoine, Paris, France.
authors: Fabrice
authors: F
authors: Carrat
authors: Inserm, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France Sorbonne Universités, UPMC Univ Paris 06, Paris, France Assistance Publique Hôpitaux de Paris, Hôpital Saint Antoine, Paris, France.
authors: Karine
authors: K
authors: Lacombe
authors: Center for AIDS Research, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia, USA.
authors: Raymond F
authors: RF
authors: Schinazi
authors: Inserm and Unit of Regulation of Retroviral Infections, Department of Virology, Institut Pasteur, Paris, France.
authors: Françoise
authors: F
authors: Barré-Sinoussi
authors: ANRS (France Recherche Nord & Sud Sida-HIV Hépatites), Paris, France.
authors: Jean-François
authors: JF
authors: Delfraissy
authors: Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon, France Department of Hepatology, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France.
authors: Fabien
authors: F
authors: Zoulim
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D004279:DNA, Viral / Q000032:analysis*; D018450:Disease Progression; D014943:Global Health; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy / Q000821:virology; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral
keywords: HEPATITIS B