title: Outcomes among patients with sex cord stromal tumour of ovary: experience from Pakistan.
abstract: BACKGROUND
  Ovarian sex cord-stromal tumours (SCST) are relatively uncommon neoplasms that account for approximately 5-7% of all primary ovarian tumours. The aim was to report experience with sex cord stromal tumours (SCST) of ovary in a low and middle income country.
  
  
  METHODS
  Clinical records of 56 patients with histopathologically-established SCST of ovary admitted to a tertiary care cancer hospital in Pakistan between April 1995 and December 2011 were reviewed.
  
  
  RESULTS
  Median age at presentation was 41 years (Range 4-77). Forty one (73%) patients were premenopausal and 15 (26.8%) were postmenopausal. The most common presenting complaint was abdominal pain (28.1%). Thirty seven patients (66%) had stage-I, 2 had stage II and II each, and 15 (26.8%) had stage IV disease. Five years survival in patients with early stage (stages I & II) was 91% while in those in the late stage (II & IV) was 84% (p=0.79). Histopathologically, 49 patients (85.7%) had Granulosa cell tumour, and 7 (12.5%) had Sertoli Lyedig cell tumour. CA-125 was high only in 8 patients (14.3%). Adjuvant chemotherapy was give in 16 (28.6%). Thirty six (64%) were disease free at last follow up, 10 (18%) succumbed to disease and 10 (18%) were alive with disease. On univariate and multivariate analyses, late stage at presentation was the sole factor significantly associated with mortality.
  
  
  CONCLUSIONS
  Ovarian sex cord-stromal tumours of ovary are relatively uncommon malignancies with good prognosis if diagnosed early and treated adequately. Survival in our study was comparable to those reported elsewhere. Among various factors, late stage of tumour at presentation was found to be the only factor significantly associated with mortality.
authors: Sohail
authors: S
authors: Sarwar
authors: Neelam
authors: N
authors: Siddiqui
authors: Sohail
authors: S
authors: Ather
authors: Abdul
authors: A
authors: Hannan
authors: Amir
authors: A
authors: Ali Syed
authors: Waleed
authors: W
authors: Zafar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy*; D010052:Ovariectomy; D010154:Pakistan; D058994:Salpingectomy; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology* / Q000628:therapy*; D015996:Survival Rate; D055815:Young Adult