title: Patients' satisfaction in early breast cancer treatment: Change in treatment over time and impact of HER2-targeted therapy.
abstract: Although breast cancer remains a major cause of cancer death, its related death rate has dropped in the last years through early tumor detection and better available treatments. With the development of innovative techniques and new molecules as well as new routes of administration, local treatment and adjuvant therapy of early breast cancer have evolved, from mutilating, time-consuming and/or painful procedures to breast-conservative ones, sparing healthy tissues, reducing the total dose of treatment and the treatment time which in turn reduce the occurrence and severity of toxicity. In parallel with these improvements leading to an increase in survival rate, patients' health-related quality of life has become a major concern. This review aims at describing the evolution of early breast cancer treatment, and its impact on patients' quality of life, convenience, and satisfaction, including a special insight into emerging human epidermal growth factor receptor 2 (HER2)-targeted therapy.
authors: Department of Medical Oncology, GHPS-CFX, APHP, IUC/UPMC, INSERM_UMRS1136, Paris, France. Electronic address: jean-philippe.spano@psl.aphp.fr.
authors: Jean-Philippe
authors: JP
authors: Spano
authors: Department of Radiation Oncology, Institut du Cancer Montpellier - Val d'Aurelle (ICM), Montpellier, France.
authors: David
authors: D
authors: Azria
authors: Department of Medical Oncology, Institut Paoli-Calmettes, Cancer Research Center of Marseille, Aix-Marseille University, Marseille, France.
authors: Anthony
authors: A
authors: Gonçalves
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D017060:Patient Satisfaction; D011788:Quality of Life; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases
keywords: Chemotherapy; Early breast cancer; HER2-targeted therapy; Quality of life; Radiotherapy; Satisfaction; TDM-1; Trastuzumab