title: Next generation sequencing for molecular confirmation of hereditary sudden cardiac death syndromes.
abstract: Hereditary sudden cardiac death syndromes comprise a wide range of diseases resulting from alteration in cardiac ion channels. Genes involved in these syndromes represent diverse mutations that cause the altered encoding of the diverse proteins constituting these channels, thus affecting directly the currents of the corresponding ions. In the present article we will briefly review how to arrive to a clinical diagnosis and we will present the results of molecular genetic studies made in Mexican subjects attending the SCD Syndromes Clinic of the National Institute of Cardiology of Mexico City.
authors: Departamento de Electrofisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico. Electronic address: manlio.marquez@gmail.com.
authors: Manlio F
authors: MF
authors: Márquez
authors: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico.
authors: David
authors: D
authors: Cruz-Robles
authors: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico.
authors: Selene
authors: S
authors: Ines-Real
authors: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico.
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Departamento de Electrofisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico.
authors: Manuel
authors: M
authors: Cárdenas
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac; D005260:Female; D006323:Heart Arrest / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D017422:Sequence Analysis, DNA; D013577:Syndrome; D055815:Young Adult
keywords: Arrhythmias; Arritmias; Brugada syndrome; Displasia Arritmogénica del ventriculo derecho; Hereditary sudden cardiac death syndromes; Right ventricle arrhythmogenic cardiomyopathy; Síndrome de Brugada; Síndromes hereditarios de muerte súbita