title: Effect of Corticosteroids on RVNA production of a patient with acute disseminated encephalomyelitis following rabies vaccination as well as administration of HRIG.
abstract: It has not been reported that administration of combining rabies vaccines and immunoglobulin resulted in acute disseminated encephalomyelitis (ADEM) yet. This report described that an old man acquired ADEM after being administrated with purified Vero cell rabies vaccine (PVRV) and Human Rabies Immunoglobulin (HRIG). Then he was given intravenous and oral glucocorticoids. Simultaneously, rabies vaccination was continued with purified Chick embryo cell vaccines (PCECV) instead of PVRV. Furthermore, we analyzed the rabies virus neutralizing antibodies (RVNA) levels in the patient's blood at different time points after rabies vaccination. Collectively, we observed that PCECV vaccination did not affect the prognosis of ADEM, and glucocorticoid was crucial and effective, which had no significant influence on efficacy of PCECV.
authors: a Department of Neurology; Union Hospital; Tongji Medical College ; Huazhong University of Science and Technology ; Wuhan , China.
authors: Jun
authors: J
authors: Peng
authors: Li
authors: L
authors: Chen
authors: Zheng-Gang
authors: ZG
authors: Zhu
authors: Ze-Rong
authors: ZR
authors: Zhu
authors: Quan
authors: Q
authors: Hu
authors: Yuan
authors: Y
authors: Fang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000368:Aged; D057134:Antibodies, Neutralizing / Q000096:biosynthesis*; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D008297:Male; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014611:Vaccination
chemical_list: D000305:Adrenal Cortex Hormones; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007136:Immunoglobulins; D011819:Rabies Vaccines
keywords: ADEM; ADEM, acute disseminated encephalomyelitis; ANCA, Antineutrophil cytoplasmic antibodies; ASO, Anti-streptolycin O; CRP, C-reactive protein; CSF, Cerebrospinal fluid; CT, Computed tomography; EEG, electroencephalography; ESR, Erythrocyte sedimentation rate; FLAIR, fluid-attenuated inversion recovery; HDCV, human diploid cell vaccine; HRIG; HRIG, Human Rabies Immunoglobulin; MRI, magnetic resonance image; MS, multiple sclerosis; PCECV, purified Chick embryo cell vaccines; PEP, post-exposure prophylaxis; PPRC, Pharmacopoeia of the People's Republic of China; PVRV; PVRV, purified Vero cell rabies vaccine; RABV, rabies virus; RFFIT, rapid fluorescent focus inhibition test; RVNA; RVNA, rabies virus neutralizing antibodies; T2W, T2-weighted; glucocorticoids