title: The role of FoxJ2 in the migration of human glioma cells.
abstract: Previous studies have demonstrated that FoxJ2 (forkhead box J2) is a member of Forkhead Box transcription factors and acts as an important prognostic indicator in human breast cancer. Our study aimed to assess the expression and function in human glioma. Western blot analysis and immunohistochemistry were performed in human glioma tissues. Low FoxJ2 expression was observed in 80 samples and its level was correlated with the grade of malignancy. A strongly positive correlation was observed between FoxJ2 and E-cadherin. Overexpression of FoxJ2 increased E-cadherin expression and decreased vimentin expression. The wound healing and transwell assays showed that overexpression of FoxJ2 significantly inhibited their migration in U87 cells. Consistent with this, knockdown of FoxJ2 promoted cellular motility. In a word, FoxJ2 suppressed cell migration and invasion in glioma, which might be a potential novel molecular targeted therapy for surgery and immune treatment.
authors: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004, People's Republic of China; Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
authors: Xiaojun
authors: X
authors: Qiu
authors: Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
authors: Bin
authors: B
authors: Ji
authors: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006, People's Republic of China.
authors: Lixiang
authors: L
authors: Yang
authors: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
authors: Qingfeng
authors: Q
authors: Huang
authors: Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
authors: Wei
authors: W
authors: Shi
authors: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
authors: Zongmei
authors: Z
authors: Ding
authors: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
authors: Xiaojuan
authors: X
authors: He
authors: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
authors: Na
authors: N
authors: Ban
authors: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of China.
authors: Shaochen
authors: S
authors: Fan
authors: Department of Pathology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001, People's Republic of China.
authors: Jianguo
authors: J
authors: Zhang
authors: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004, People's Republic of China. Electronic address: dryetian@hotmail.com.
authors: Ye
authors: Y
authors: Tian
mesh_terms: D000328:Adult; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D005455:Fluorescent Antibody Technique; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D034741:RNA, Small Interfering; D014162:Transfection
chemical_list: C408469:FOXJ2 protein, human; D051858:Forkhead Transcription Factors; D034741:RNA, Small Interfering
keywords: FoxJ2; Glioma; Migration; Prognosis