title: TCL1 expression predicts overall survival in patients with mantle cell lymphoma.
abstract: OBJECTIVE
  Mantle cell lymphoma (MCL) has a heterogeneous clinical course. Although most cases show a poor prognosis, a minority has an indolent course. It is difficult to identify indolent MCL cases prospectively. T-cell leukemia/lymphoma protein 1 (TCL1) is expressed by several B-cell lymphomas, including MCL. This study examined the expression of TCL1 and its prognostic relevance for MCL.
  
  
  METHODS
  Clinical data for 162 patients with MCL were collected. Of these, 144 cases with available tissues for tissue microarray construction and immunostaining were included in the analysis. TCL1 staining was quantified using the Nuclear Quant application with Pannoramic™ Viewer v. 1.14. High TCL1 expression was defined as moderate to strong nuclear and/or cytoplasmic staining in 40% or more of the cells.
  
  
  RESULTS
  High TCL1 expression was observed in 39 of 144 samples (27.1%). Patients with low TCL1 expression were more likely to present with blastoid/pleomorphic morphology (P = 0.010). Low TCL1 expression was associated with significantly shorter overall survival (OS, P = 0.006). Multivariate analysis identified low TCL1 expression (P = 0.003), high-risk MIPI (P = 0.027), and anemia (P = 0.018) as adverse prognostic factors.
  
  
  CONCLUSIONS
  Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL and call for prospective studies.
authors: Departments of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Su-Jin
authors: SJ
authors: Shin
authors: Departments of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Jin
authors: J
authors: Roh
authors: Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors: Hee Jeong
authors: HJ
authors: Cha
authors: Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
authors: Yoo Duk
authors: YD
authors: Choi
authors: Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Jin-Man
authors: JM
authors: Kim
authors: Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
authors: Soo Kee
authors: SK
authors: Min
authors: Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea.
authors: Ji Eun
authors: JE
authors: Kim
authors: Departments of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea.
authors: Dae-Woon
authors: DW
authors: Eom
authors: Department of Pathology, Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
authors: Hojung
authors: H
authors: Lee
authors: Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors: Hyun-Jung
authors: HJ
authors: Kim
authors: Departments of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Dok Hyun
authors: DH
authors: Yoon
authors: Departments of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Cheolwon
authors: C
authors: Suh
authors: Departments of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Jooryung
authors: J
authors: Huh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D014408:Biomarkers, Tumor; D003131:Combined Modality Therapy; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012372:ROC Curve; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; C090851:TCL1A protein, human
keywords: T-cell leukemia/lymphoma protein 1; mantle cell lymphoma; mantle cell lymphoma international prognostic index; prognosis