title: 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls.
abstract: Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n = 10) and healthy controls (n = 10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required.
authors: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Pavan
authors: P
authors: Bhargava
authors: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Anne
authors: A
authors: Gocke
authors: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: pcalabr1@jhmi.edu.
authors: Peter A
authors: PA
authors: Calabresi
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D002117:Calcitriol / Q000172:deficiency* / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D054367:Receptors, CXCR3 / Q000378:metabolism; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology*; D014808:Vitamin D Deficiency / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD; C515187:CXCR3 protein, human; D054367:Receptors, CXCR3; D002117:Calcitriol
keywords: Immunological memory; Multiple sclerosis; T cell; Vitamin D