title: Maternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype.
abstract: We examined transgenerational effects of maternal childhood adversity on child temperament and a functional promoter polymorphism, 5-HTTLPR, in the serotonin-transporter gene (SLC6A4) as potential moderators of such maternal influences in 154 mother-child dyads, recruited into a longitudinal birth cohort study. We examined the interactive effects of maternal childhood experience using an integrated measure derived from Childhood Trauma Questionnaire (CTQ) and Parental Bonding Index (PBI). Triallelic genotyping of 5-HTTLPR was performed. A measure of 'negative emotionality/behavioural dysregulation' was derived from the Early Childhood Behaviour Questionnaire at 18 and 36 months. Negative emotionality/behavioural dysregulation was highly stable between 18 and 36 months and predicted psychosocial problems at 60 months. After controlling multiple demographics as well as both previous and concurrent maternal depression there was a significant interaction effect of maternal childhood adversity and offspring 5-HTTLPR genotype on child negative emotionality/behavioural dysregulation (β = 1.03, t(11,115) = 2.71, P < .01). The results suggest a transgenerational effect of maternal developmental history on emotional function in the offspring, describing a pathway that likely contributes to the familial transmission of vulnerability for psychopathology.
authors: Douglas Mental Health University Institute of McGill University; Département de Psychologie, Université de Montréal.
authors: Andrée-Anne
authors: AA
authors: Bouvette-Turcot
authors: A S
authors: AS
authors: Fleming
authors: A
authors: A
authors: Wazana
authors: M B
authors: MB
authors: Sokolowski
authors: H
authors: H
authors: Gaudreau
authors: A
authors: A
authors: Gonzalez
authors: J
authors: J
authors: Deslauriers
authors: J L
authors: JL
authors: Kennedy
authors: M
authors: M
authors: Steiner
authors: M J
authors: MJ
authors: Meaney
mesh_terms: D000328:Adult; D002649:Child Abuse / Q000523:psychology*; D002675:Child, Preschool; D015331:Cohort Studies; D003863:Depression / Q000235:genetics* / Q000523:psychology*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D009034:Mother-Child Relations / Q000523:psychology*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013694:Temperament
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5-HTTLPR genotype; Differential susceptibility; maternal adversity; negative emotionality; transgenerational transmission