title: Quinine conjugates and quinine analogues as potential antimalarial agents.
abstract: Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a million deaths annually; efforts to develop new antimalarial agents are therefore particularly important. Quinine continues to play a role in the fight against malaria, but quinoline derivatives are more widely used. Drugs based on the quinoline scaffold include chloroquine and primaquine, which are able to act against the blood and liver stages of the parasite's life cycle. The purpose of this review is to discuss reported biologically active compounds based on either the quinine or quinoline scaffold that may have enhanced antimalarial activity. The review emphasises hybrid molecules, and covers advances made in the last five years. The review is divided into three sections: modifications to the quinine scaffold, modifications to aminoquinolines and finally metal-containing antimalarial compounds.
authors: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, FL 32611-7200, USA. Electronic address: rajones@ufl.edu.
authors: Rachel A
authors: RA
authors: Jones
authors: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, FL 32611-7200, USA.
authors: Siva S
authors: SS
authors: Panda
authors: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, FL 32611-7200, USA.
authors: C Dennis
authors: CD
authors: Hall
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D011803:Quinine / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D011803:Quinine
keywords: Chloroquine; Ferroquine; Heterocycles; Hybrid drugs; Malaria; Quinine