title: Fibulin-5 is a prognostic marker that contributes to proliferation and invasion of human glioma cells.
abstract: Fibulin-5 has recently been considered as a potential tumor suppressor in human cancers. Several studies have shown that it is down-regulated in a variety of tumor types and inhibits tumor growth and metastasis. This study was aimed to investigate the clinical significance of fibulin-5 in glioma and its role in cell proliferation and invasion. We found that the expression of fibulin-5 in glioma tissues was significantly lower than those in normal brain (NB) tissues. Negative expression was significantly correlated with advanced clinical stage (grade III+IV). Furthermore, Fibulin-5 negative expression was correlated with a shorter overall survival of glioma patients. Multivariate Cox repression analysis indicated that fibulin-5 was an independent factor for predicting overall survival of glioma patients. Overexpression obviously inhibited cell proliferation in U251 and U87 cells. Furthermore, it significantly reduced the number of migrating and invading glioma cells. In conclusion, impaired expression of fibulin-5 is correlated with the advanced tumor stage in glioma. Otherwise, Fibulin-5 is an independent prognostic marker for predicting overall survival of glioma patients. Mechanistically, it may function as a tumor suppressor via inhibiting cell proliferation and invasion in gliomas.
authors: Department of Neurosurgery, the First Affiliated Hospital of Xi'an Medical College, Xi'an, China E-mail : jgsy_2014@sina.com.
authors: Xu-Dong
authors: XD
authors: Sheng
authors: Hu
authors: H
authors: Chen
authors: Hui
authors: H
authors: Wang
authors: Zhi-Bin
authors: ZB
authors: Ding
authors: Gang-Zhu
authors: GZ
authors: Xu
authors: Jun-Feng
authors: JF
authors: Zhang
authors: Wen-Chao
authors: WC
authors: Lu
authors: Tao
authors: T
authors: Wu
authors: Ling
authors: L
authors: Zhao
mesh_terms: D017209:Apoptosis; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D014407:Tumor Cells, Cultured
chemical_list: D016326:Extracellular Matrix Proteins; C492373:FBLN5 protein, human