title: Enantioselective conjugate additions of α-amino radicals via cooperative photoredox and Lewis acid catalysis.
abstract: We report the highly enantioselective addition of photogenerated α-amino radicals to Michael acceptors. This method features a dual-catalyst protocol that combines transition metal photoredox catalysis with chiral Lewis acid catalysis. The combination of these two powerful modes of catalysis provides an effective, general strategy to generate and control the reactivity of photogenerated reactive intermediates.
authors: Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.
authors: Laura
authors: L
authors: Ruiz Espelt
authors: Iain S
authors: IS
authors: McPherson
authors: Eric M
authors: EM
authors: Wiensch
authors: Tehshik P
authors: TP
authors: Yoon
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005609:Free Radicals / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013237:Stereoisomerism
chemical_list: D000588:Amines; D005609:Free Radicals; D058116:Lewis Acids