title: Correlation between IGF2BP2 gene polymorphism and the risk of breast cancer in Chinese Han women.
abstract: OBJECTIVE
  To investigate the correlations between the polymorphism of IGF2BP2, a diabetes predisposing gene, and breast cancer risk in Chinese female with Han nationality.
  
  
  METHODS
  The genomic DNAs were extracted from the peripheral blood drawn from 564 female breast cancer patients and 394 healthy females of Han nationality. The polymorphism of IGF2BP2 gene rs4402960 was detected by a multiplex PCR-Ligase detection reaction (PCR-LDR) assay from genomic DNA. The correlations between genotype and breast cancer risk as well as clinicopathologic characteristics were compared.
  
  
  RESULTS
  The differences are significant between genotype distribution of IGF2BP2 gene rs4402960 (P=0.009) and allele gene frequency from both disease and control groups. Both T gene carriers (GT+TT) (OR=1.462; 95% CI, 1.127-1.897) and T allele gene (OR=1.382; 95% CI, 1.116-1.710) significantly increase the risk of breast cancer. No considerable correlations were observed between the polymorphism of rs4402960 and the clinical pathological parameters, such as age at diagnosis, lymphatic metastasis, estrogen and progesterone receptor status, cerb-B2 receptor status, and tumor staging.
  
  
  CONCLUSIONS
  The IGF2BP2 gene rs4402960 polymorphism increases the breast cancer risk of Chinese females with Han nationality, and is a breast cancer predisposing gene.
authors: Department of Endocrinology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China.
authors: Guihong
authors: G
authors: Liu
authors: Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Hebei Medical University, Shijiazhuang 050017, China; Department of Medical Oncology, Bethune International Peace Hospital, Shijiazhuang 050082, China. Electronic address: tienian_zhu@hotmail.com.
authors: Tienian
authors: T
authors: Zhu
authors: Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Hebei Medical University, Shijiazhuang 050017, China.
authors: Yujie
authors: Y
authors: Cui
authors: Department of Medical Oncology, Bethune International Peace Hospital, Shijiazhuang 050082, China.
authors: Jingpu
authors: J
authors: Liu
authors: Department of Medical Oncology, Bethune International Peace Hospital, Shijiazhuang 050082, China.
authors: Jiankun
authors: J
authors: Liu
authors: Department of Medical Oncology, Bethune International Peace Hospital, Shijiazhuang 050082, China.
authors: Qinglan
authors: Q
authors: Zhao
authors: Department of Medical Oncology, The First hospital of Shijiazhuang City, Shijiazhuang 050011, China.
authors: Kai
authors: K
authors: Zhang
authors: Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Department of Immunology, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: 6810c@163.com.
authors: Ruijing
authors: R
authors: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; C498779:IGF2BP2 protein, human; D016601:RNA-Binding Proteins
keywords: Breast cancer; IGF2BP2 gene; Single nucleotide polymorphism