title: Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans.
abstract: Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans.
authors: Pediatric Pulmonology Unit, First Department of Pediatrics, University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.
authors: Kalliopi
authors: K
authors: Tanou
authors: Athina
authors: A
authors: Xaidara
authors: Athanasios G
authors: AG
authors: Kaditis
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001989:Bronchiolitis Obliterans / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D010092:Oximetry; D010991:Plethysmography; D013147:Spirometry; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
keywords: bronchiolitis obliterans; nocturnal hypoxemia; pulse methylprednisolone