title: Exhaled breath volatile biomarker analysis for thyroid cancer.
abstract: Compared with other types of cancer, thyroid cancer incidence rates have increased rapidly worldwide in the past few decades. In recent years, potential thyroid cancer biomarkers have been studied, but these biomarkers have neither specificity nor good positive predictive value. Exhaled breath analysis is a recently developed convenient and noninvasive method for screening and diagnosing the disease. In this study, potential thyroid cancer biomarkers in volatile organic compounds (VOCs) were detected. Exhaled breath was collected from 64 patients with histologically confirmed cases of thyroid disease (including 39 individuals with papillary thyroid carcinoma and 25 individuals with nodular goiters) and 32 healthy volunteers. Solid-phase microextraction-gas chromatography and mass spectrometry was used to assess the exhaled VOCs of the study participants. The statistical methods of principal component analysis and partial least-squares discriminant analysis were performed to process the final data. The VOCs exhibited significant differences between nodular goiter patients and normal controls, papillary thyroid carcinoma patients and normal controls, and papillary thyroid carcinoma patients and nodular goiter patients; 7, 7, and 3 characteristic metabolites played decisive roles in sample classification, respectively. Breath analysis may provide a new, noninvasive, and directly qualitative method for the clinical diagnosis of thyroid disease.
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Lei
authors: L
authors: Guo
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Changsong
authors: C
authors: Wang
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Chunjie
authors: C
authors: Chi
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Xiaoyang
authors: X
authors: Wang
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Shanshan
authors: S
authors: Liu
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: Wei
authors: W
authors: Zhao
authors: Department of Biostatistics, School of Public Health, Harbin Medical University, Harbin, China.
authors: Chaofu
authors: C
authors: Ke
authors: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
authors: Guowang
authors: G
authors: Xu
authors: Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: enyouli@aliyun.com.
authors: Enyou
authors: E
authors: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D002277:Carcinoma / Q000175:diagnosis; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D045853:Exhalation; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D015415:Biomarkers; D055549:Volatile Organic Compounds