title: Expect the Unexpected: Report of a Case of Pediatric Pharyngeal Extraosseous Plasmacytoma with Tumefactive Amyloidosis ("Amyloidoma") and a Review of the Literature.
abstract: We report a rare case of localized pharyngeal tumefactive amyloidosis caused by extraosseous plasmacytoma in a 12 year-old girl who presented with otalgia, sore throat and blood stained sputum. The tumor was predominantly composed of amyloid with a limited component of well-differentiated neoplastic plasma cells, which were monoclonal (kappa restricted) on light chain in-situ hybridization. The amyloid deposits were positive for kappa immunoglobulin light chain on immunohistochemistry. The patient was treated with a combination of surgery and radiotherapy. Follow-up at 1 year showed no evidence of recurrence or progression.
authors: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
authors: Char Loo
authors: CL
authors: Tan
authors: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
authors: Sze Hwa
authors: SH
authors: Tan
authors: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
authors: Siok Bian
authors: SB
authors: Ng
authors: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. fredrikpetersson@live.se.
authors: Fredrik
authors: F
authors: Petersson
mesh_terms: D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D010610:Pharyngeal Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy
keywords: Amyloidosis; Extraosseous; Pediatric; Plasma cell neoplasm; Plasmacytoma