title: The role of IL-33/ST2L signals in the immune cells.
abstract: Interleukin (IL)-33 signals influence various immune cells during differentiation, immune responses and homeostasis. As discussed in this Review, IL-33 via TI/ST2L regulates the functions of immune cells including T cells, B cells, DCs, macrophages, mast cells, and innate lymphoid cells (ILCs). Stimulation with IL-33 is crucial for CD4+ T cell polarized into Th2 immunity and for the induction of Treg. CD8+ T cells can also express ST2L and IL-33 promotes features of effector CD8+ T cells. For macrophages and ILCs, ST2L presents on these cells and IL-33 induces Th2 cytokine production. IL-33 modulates adhesion, activation, maturation, and cytokine production by mast cells. ST2 is expressed in B1 and is important for differentiation of IL-10-producing B cells. Understanding the specific role of IL-33/ST2L in different immune cells will help to answer the remaining questions that are important for diseases pathologies and intervention strategies by targeting the IL-33/ST2L signals.
authors: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
authors: Jingli
authors: J
authors: Lu
authors: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
authors: Jian
authors: J
authors: Kang
authors: Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: Chengliang
authors: C
authors: Zhang
authors: Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. Electronic address: firstph@163.com.
authors: Xiaojian
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D011956:Receptors, Cell Surface
keywords: IL-33; Immune cells; ST2L; sST2