title: Cancer mortality in towns in the vicinity of installations for the production of cement, lime, plaster, and magnesium oxide.
abstract: Our objective was to investigate whether there might be excess cancer mortality in the vicinity of Spanish installations for the production of cement, lime, plaster, and magnesium oxide, according to different categories of industrial activity. An ecologic study was designed to examine municipal mortality due to 33 types of cancer (period 1997-2006) in Spain. Population exposure to pollution was estimated on the basis of distance from town to industrial facility. Using spatial Besag-York-Mollié regression models with integrated nested Laplace approximations for Bayesian inference, we assessed the relative risk of dying from cancer in a 5-km zone around installations, analyzed the effect of category of industrial activity according to the manufactured product, and conducted individual analyses within a 50-km radius of each installation. Excess all cancer mortality (relative risk, 95% credible interval) was detected in the vicinity of these installations as a whole (1.04, 1.01-1.07 in men; 1.03, 1.00-1.06 in women), and, principally, in the vicinity of cement installations (1.05, 1.01-1.09 in men). Special mention should be made of the results for tumors of colon-rectum in both sexes (1.07, 1.01-1.14 in men; 1.10, 1.03-1.16 in women), and pleura (1.71, 1.24-2.28), peritoneum (1.62, 1.15-2.20), gallbladder (1.21, 1.02-1.42), bladder (1.11, 1.03-1.20) and stomach (1.09, 1.00-1.18) in men in the vicinity of all such installations. Our results suggest an excess risk of dying from cancer, especially in colon-rectum, in towns near these industries.
authors: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jgarcia@isciii.es.
authors: Javier
authors: J
authors: García-Pérez
authors: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: glabente@isciii.es.
authors: Gonzalo
authors: G
authors: López-Abente
authors: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: acastello@isciii.es.
authors: Adela
authors: A
authors: Castelló
authors: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: mariogonzalez@isciii.es.
authors: Mario
authors: M
authors: González-Sánchez
authors: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: pfernandezn@isciii.es.
authors: Pablo
authors: P
authors: Fernández-Navarro
mesh_terms: D000328:Adult; D017610:Calcium Compounds / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000401:mortality; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality; D008277:Magnesium Oxide / Q000009:adverse effects*; D008297:Male; D066192:Manufacturing Industry; D009369:Neoplasms / Q000401:mortality*; D010087:Oxides / Q000009:adverse effects*; D012306:Risk; D013030:Spain / Q000453:epidemiology
chemical_list: D017610:Calcium Compounds; D010087:Oxides; D008277:Magnesium Oxide; C016538:lime
keywords: BYM model; Cancer mortality; Cement plants; INLA; Industrial pollution; Lime plants