title: Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas.
abstract: We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM-OCT signal from the aorta samples specimens injected with targeted MSs.
authors: Jongsik
authors: J
authors: Kim
authors: Adeel
authors: A
authors: Ahmad
authors: Joanne
authors: J
authors: Li
authors: Marina
authors: M
authors: Marjanovic
authors: Eric J
authors: EJ
authors: Chaney
authors: Kenneth S
authors: KS
authors: Suslick
authors: Stephen A
authors: SA
authors: Boppart
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology*; D050197:Atherosclerosis / Q000150:complications* / Q000175:diagnosis*; D057785:Catheters; D006949:Hyperlipidemias / Q000150:complications*; D060328:Magnetic Phenomena; D008297:Male; D008863:Microspheres; D011092:Polyethylene Glycols / Q000737:chemistry; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
chemical_list: D011092:Polyethylene Glycols