title: Is admission screening for Pseudomonas aeruginosa useful in haematologic patients? A prospective study with 1310 patients.
abstract: Screening for Pseudomonas aeruginosa is recommended to guide empirical antimicrobial therapy in patients on high-risk units. However, evidence for this approach is scarce. We therefore screened 1310 patients with severe haematologic diseases for P. aeruginosa colonization at admission: 108 (8.2%) were positive, but only nine (0.7%; six with the same clone as in the screening isolate) subsequently developed a P. aeruginosa bloodstream infection (positive predictive value of screening, 8.6%; negative predictive value of screening, 99.5%). Routine screening for P. aeruginosa at admission did not sufficiently predict subsequent bloodstream infections caused by P. aeruginosa.
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland.
authors: J A
authors: JA
authors: Sidler
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland; Clinical Microbiology, Switzerland.
authors: R
authors: R
authors: Frei
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland.
authors: S
authors: S
authors: Tschudin-Sutter
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland.
authors: M
authors: M
authors: Dangel
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland.
authors: M
authors: M
authors: Battegay
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland.
authors: M
authors: M
authors: Weisser
authors: Haematology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
authors: J
authors: J
authors: Passweg
authors: Divisions of Infectious Diseases and Hospital Epidemiology, Switzerland. Electronic address: andreas.widmer@usb.ch.
authors: A F
authors: AF
authors: Widmer
mesh_terms: D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D002353:Carrier State / Q000175:diagnosis* / Q000382:microbiology*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D010343:Patient Admission; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*
keywords: Bloodstream infection; Pseudomonas aeruginosa; colonization; molecular typing; screening