title: An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia.
abstract: Epidemiological studies have indicated that both maternal bacterial and viral infections during pregnancy increase the risk of schizophrenia among offspring, but to date there is not clear explanation for this increased risk. Previously, the decreased C4b-binding protein (C4BP), a potent circulating soluble inhibitor of the classical and lectin pathways of complement, was reported to be associated with risk of schizophrenia. Here, we analyzed 4 common single nucleotide polymorphisms (SNPs) of C4BPB and 5 SNPs of C4BPA in a group of 556 schizophrenia patients and a matched group of 610 healthy controls to see if the genes C4BPB and C4BPA, which encode C4BP, may confer a susceptibility to schizophrenia. Comparing the genotype and allele frequencies of those SNPs between cases and controls, we found no association between the C4BPB/C4BPA variants and schizophrenia. Our results provided preliminary evidence that C4BPB/C4BPA may not confer susceptibility to schizophrenia among Han Chinese. Further genetic studies from large-scale population are required to obtain more conclusive results.
authors: Tongde Hospital of Zhejiang Province, Zhejiang, China.
authors: Shuihong
authors: S
authors: Wang
authors: The People's Hospital of Changxing County, Zhejiang, China.
authors: Houquan
authors: H
authors: Lu
authors: Tongde Hospital of Zhejiang Province, Zhejiang, China.
authors: Jianliang
authors: J
authors: Ni
authors: Tongde Hospital of Zhejiang Province, Zhejiang, China.
authors: Jiangtao
authors: J
authors: Zhang
authors: Hangzhou Seventh People's Hospital, Zhejiang, China.
authors: Wenxin
authors: W
authors: Tang
authors: Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Weihong
authors: W
authors: Lu
authors: Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Jun
authors: J
authors: Cai
authors: Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhangchen645@gmail.com.
authors: Chen
authors: C
authors: Zhang
mesh_terms: D000328:Adult; D050716:Complement C4b-Binding Protein / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006649:Histocompatibility Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C055609:C4BPA protein, human; C489165:C4BPB protein, human; D050716:Complement C4b-Binding Protein; D006649:Histocompatibility Antigens
keywords: C4b-binding protein; Polymorphism; Schizophrenia