title: Interferon-inducible protein 10 (IP-10) is associated with viremia of early HIV-1 infection in Korean patients.
abstract: Cytokines/chemokines play key roles in modulating disease progression in human immunodeficiency virus (HIV) infection. Although it is known that early HIV-1 infection is associated with increased production of proinflammatory cytokines, the relationship between cytokine levels and HIV-1 pathogenesis is not clear. The concentrations of 18 cytokines/chemokines in 30 HIV-1 negative and 208 HIV-1 positive plasma samples from Korean patients were measured by the Luminex system. Early HIV-1 infection was classified according to the Fiebig stage (FS) based on the characteristics of the patients infected with HIV-1. Concentrations of interleukin-12 (IL-12), interferon-inducible protein-10 (IP-10), macrophage inflammatory protein-1α (MIP-1α) and regulated upon activation, normal T cells expressed and secreted (RANTES) were increased significantly during the early stage of HIV-1 infection (FS II-IV) compared with the HIV-1-negative group. Of these cytokines, an elevated level of IP-10 was the only factor to be correlated positively with a higher viral load during the early stages of HIV-1 infection (FS II-IV) in Koreans (R = 0.52, P < 0.0005). Therefore, these results suggest that IP-10 may be an indicator for HIV-1 viremia and associated closely with viral replication in patients with early HIV-1 infection.
authors: Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Chungbuk, Republic of Korea.
authors: SoYong
authors: S
authors: Lee
authors: Yoon-Seok
authors: YS
authors: Chung
authors: Cheol-Hee
authors: CH
authors: Yoon
authors: YoungHyun
authors: Y
authors: Shin
authors: SeungHyun
authors: S
authors: Kim
authors: Byeong-Sun
authors: BS
authors: Choi
authors: Sung Soon
authors: SS
authors: Kim
mesh_terms: D044466:Asian People; D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D019562:Viral Load; D014766:Viremia
chemical_list: D015415:Biomarkers; D054357:Chemokine CXCL10
keywords: IP-10; chemokines; cytokines; human immunodeficiency virus (HIV); viremia