title: Methylene blue for burn-induced vasoplegia: case report and review of literature.
abstract: We report the use of a single dose of methylene blue in a patient with burn-induced vasoplegia refractory to fluids, vasopressors, and steroids. Administration of methylene blue allowed for cessation of epinephrine infusion within 2 hours of administration, and reduction in excessive fluid resuscitation. The patient's clinical course continued for 2 months and was complicated by severe acute respiratory distress syndrome, pneumonia, septic shock, poor skin graft adherence, renal failure requiring continuous renal replacement therapy, cutaneous mucormycosis, and ultimately, withdrawal of care and death. Despite the eventual outcome, this is the longest reported survival following methylene blue administration for vasoplegia secondary to burn injury.
authors: From the Department of Surgery, University of Michigan Health System, Ann Arbor.
authors: Joseph T
authors: JT
authors: Church
authors: Joseph A
authors: JA
authors: Posluszny
authors: Mark
authors: M
authors: Hemmila
authors: Kathleen B
authors: KB
authors: To
authors: Jill R
authors: JR
authors: Cherry-Bukowiec
authors: Jennifer
authors: J
authors: Waljee
mesh_terms: D002056:Burns / Q000150:complications / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D008875:Middle Aged; D017211:Treatment Failure; D056987:Vasoplegia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D004791:Enzyme Inhibitors; D008751:Methylene Blue