title: Immunomodulatory effects of peplomycin on immunosuppressive and cytotoxic cells in the lesional skin of cutaneous squamous cell carcinoma.
abstract: BACKGROUND
  Continuous intra-arterial administration of peplomycin (PEP) through a tumor-feeding artery using an intravascular indwelling catheter is one of the best treatments for cutaneous squamous cell carcinoma (SCC) on cosmetic areas. Although this reagent is useful for the treatment of SCC, its immunomodulatory effect on the tumor microenvironment is still unknown.
  
  
  OBJECTIVE
  In this study, we investigated the immunomodulatory effects of PEP on the tumor-infiltrating regulatory T cells and tumor-associated macrophages as well as CD8(+)TIA-1(+) cytotoxic T cells in the lesional skin of 5 patients with SCC on the lips.
  
  
  RESULTS
  Our data suggest that, in addition to the direct antitumor effects, PEP decreased immunosuppressive cells and increased cytotoxic T lymphocytes at the tumor sites, which might maintain antitumor immune response against SCC.
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Taku
authors: T
authors: Fujimura
authors: Yumi
authors: Y
authors: Kambayashi
authors: Sadanori
authors: S
authors: Furudate
authors: Aya
authors: A
authors: Kakizaki
authors: Takahiro
authors: T
authors: Haga
authors: Akira
authors: A
authors: Hashimoto
authors: Setsuya
authors: S
authors: Aiba
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D007261:Infusions, Intra-Arterial; D008046:Lip; D008264:Macrophages / Q000187:drug effects; D009389:Neovascularization, Pathologic; D017663:Peplomycin / Q000008:administration & dosage* / Q000494:pharmacology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
chemical_list: D000903:Antibiotics, Antineoplastic; D017663:Peplomycin