title: Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization.
abstract: A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.
authors: MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös University, Faculty of Science, Pázmány Péter stny. 1/A, 1117, Budapest, Hungary. novakz@elte.hu.
authors: Gergely L
authors: GL
authors: Tolnai
authors: Anna
authors: A
authors: Székely
authors: Zita
authors: Z
authors: Makó
authors: Tamás
authors: T
authors: Gáti
authors: János
authors: J
authors: Daru
authors: Tamás
authors: T
authors: Bihari
authors: András
authors: A
authors: Stirling
authors: Zoltán
authors: Z
authors: Novák
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D011789:Quantum Theory
chemical_list: C583482:2,2,2-trifluoroethyl iodide; D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D002244:Carbon; D006859:Hydrogen