title: Targeting the tumor vasculature to enhance T cell activity.
abstract: T cells play a critical role in tumor immune surveillance as evidenced by extensive mouse-tumor model studies as well as encouraging patient responses to adoptive T cell therapies and dendritic cell vaccines. It is well established that the interplay of tumor cells with their local cellular environment can trigger events that are immunoinhibitory to T cells. More recently it is emerging that the tumor vasculature itself constitutes an important barrier to T cells. Endothelial cells lining the vessels can suppress T cell activity, target them for destruction, and block them from gaining entry into the tumor in the first place through the deregulation of adhesion molecules. Here we review approaches to break this tumor endothelial barrier and enhance T cell activity.
authors: Ludwig Center for Cancer Research of the University of Lausanne, CH-1066 Epalinges, Switzerland.
authors: Evripidis
authors: E
authors: Lanitis
authors: Ludwig Center for Cancer Research of the University of Lausanne, CH-1066 Epalinges, Switzerland.
authors: Melita
authors: M
authors: Irving
authors: Ludwig Center for Cancer Research of the University of Lausanne, CH-1066 Epalinges, Switzerland; Department of Oncology, University Hospital of Lausanne (CHUV), CH-1015 Lausanne, Switzerland; Ovarian Cancer Research Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address: George.Coukos@chuv.ch.
authors: George
authors: G
authors: Coukos
mesh_terms: D000818:Animals; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism