title: Cell penetrating peptides as a therapeutic strategy in chronic lymphocytic leukemia.
abstract: PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.
authors: Issam
authors: I
authors: Arrouss
authors: Didier
authors: D
authors: Decaudin
authors: Sylvain
authors: S
authors: Choquet
authors: Nabih
authors: N
authors: Azar
authors: Christophe
authors: C
authors: Parizot
authors: Jean M
authors: JM
authors: Zini
authors: Fariba
authors: F
authors: Nemati
authors: CIMI Paris, Universite Pierre et Marie Curie, 91 bd de l'hopital 75013 Paris, France. angelita.rebollo@upmc.fr.
authors: Angelita
authors: A
authors: Rebollo
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053453:Caspase 9 / Q000378:metabolism; D057846:Cell-Penetrating Peptides / Q000494:pharmacology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D007963:Leukocytes, Mononuclear; D009360:Neoplastic Cells, Circulating; D054648:Protein Phosphatase 2 / Q000378:metabolism
chemical_list: D057846:Cell-Penetrating Peptides; C000597418:DPT-C9h peptide; D054648:Protein Phosphatase 2; D053453:Caspase 9