title: Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009.
abstract: OBJECTIVE
  Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries.
  
  
  METHODS
  Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.
  
  
  RESULTS
  The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis.
  
  
  CONCLUSIONS
  These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL.
authors: Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea.
authors: Sang-Hoon
authors: SH
authors: Shin
authors: The Korea Central Cancer Registry, National Cancer Center, Goyang, Korea.
authors: Kyu-Won
authors: KW
authors: Jung
authors: The Korea Central Cancer Registry, National Cancer Center, Goyang, Korea.
authors: Johyun
authors: J
authors: Ha
authors: Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea.
authors: Seung Hoon
authors: SH
authors: Lee
authors: The Korea Central Cancer Registry, National Cancer Center, Goyang, Korea.
authors: Young-Joo
authors: YJ
authors: Won
authors: Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea.
authors: Heon
authors: H
authors: Yoo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D017678:Sex Distribution; D016019:Survival Analysis
keywords: Central nervous system; Incidence; Korea; Lymphoma; Neoplasms; Registries; Survival