title: microRNA-184 functions as tumor suppressor in renal cell carcinoma.
abstract: microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in other tumors, its function in renal cell carcinoma (RCC) is still unknown. The aim of the present study was to investigate the role of miR-184 in RCC. The impacts of miR-184 on cell migration, proliferation and apoptosis were evaluated using migration scratch, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assay. Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosisin vitrowhen compared with the negative control (P<0.05). In this study, it was observed that miR-184 played a significant role as a tumor suppressor in RCC. Therefore, miR-184 may be a promising therapeutic target for renal cancer treatment in the future.
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Zhengming
authors: Z
authors: Su
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
authors: Duqun
authors: D
authors: Chen
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
authors: Yifan
authors: Y
authors: Li
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Enpu
authors: E
authors: Zhang
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
authors: Zuhu
authors: Z
authors: Yu
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.
authors: Ting
authors: T
authors: Chen
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Zhimao
authors: Z
authors: Jiang
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Liangchao
authors: L
authors: Ni
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Shangqi
authors: S
authors: Yang
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Yaoting
authors: Y
authors: Gui
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Jiongxian
authors: J
authors: Ye
authors: Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
authors: Yongqing
authors: Y
authors: Lai
keywords: miR-184; microRNA; renal cell carcinoma