title: Supramolecular assemblies of phenyl-pyridyl-triazolopyridine and β-cyclodextrin as sensor of divalent cations in aqueous solution.
abstract: The chemosensor 3-phenyl-7-(pyrid-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (PhPTP) used in combination with two different cyclodextrins, enable its solubilization and stabilization in aqueous solution. The behavior of the inclusion complex, and its binding ability in both cyclodextrins were investigated by means of absorption and fluorescence spectroscopy. The best results were obtained for PhPTP-DMβCD assembly, and its orientation in the DMβCD nano cavity was obtained by 2D-NMR. This inclusion geometry was confirmed by docking studies. The binary complex was proved as chemosensor upon the presence of different divalent cations in aqueous solutions. The PhPTP-DMβCD system, displays a high sensitivity for Fe(2+) by fluorescence quenching in neutral aqueous solution even in the presence of other metals showing high selectivity towards Fe(2+).
authors: Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile. Electronic address: cjullian@uchile.cl.
authors: Carolina
authors: C
authors: Jullian
authors: Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors: Samuel
authors: S
authors: Fernández-Sandoval
authors: Departamento Química Analítica e Inorgánica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors: Cristian
authors: C
authors: Celis-Barros
authors: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain.
authors: Belén
authors: B
authors: Abarca
authors: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain.
authors: Rafael
authors: R
authors: Ballesteros
authors: Departamento Química Analítica e Inorgánica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors: Gerald
authors: G
authors: Zapata-Torres
mesh_terms: D002413:Cations, Divalent / Q000737:chemistry*; D005453:Fluorescence; D007501:Iron / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: C000602632:3-phenyl-7-(pyrid-2-yl)-(1,2,3)triazolo(1,5-a)pyridine; D002413:Cations, Divalent; D011725:Pyridines; D014230:Triazoles; D047392:beta-Cyclodextrins; D014867:Water; D007501:Iron; C031215:betadex
keywords: Cyclodextrin; Fe(II); Fluorescence; Phenylpyridyltriazolopyridine; Sensor