title: Pd-catalyzed Csp(2) -H functionalization of heteroarenes via isocyanide insertion: concise synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines.
abstract: We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.
authors: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven (Belgium) http://chem.kuleuven.be/en/research/mds/lomac.
authors: Upendra K
authors: UK
authors: Sharma
authors: Nandini
authors: N
authors: Sharma
authors: Jun
authors: J
authors: Xu
authors: Gonghua
authors: G
authors: Song
authors: Erik V
authors: EV
authors: Van der Eycken
keywords: CH activation; azoles; heteroarenes; isocyanide insertion; palladium