title: Mycobacterium bovid infection of total knee arthroplasty after bacille Calmette-Guérin therapy for bladder cancer.
abstract: We present a case of Mycobacterium bovis infection of a total knee arthroplasty. This infection developed after use of bacillus Calmette-Guérin immunotherapy used to treat superficial bladder cancer. The patient presented with joint stiffness. Radiographs and inflammatory markers were normal. Six weeks after arthroscopy for synovectomy and biopsy, cultures showed M bovis infection of the knee joint. The patient was switched to antitubercular chemotherapy treatment, which resulted in the successful retention of implants. Seven and a half years later, the patient is symptom-free with high function in the joint. To our knowledge, this is the first time that this type of joint infection did not lead to removal.
authors: River Valley Orthopedics, Grand Rapids, MI. rispdt@mercyhealth.com.
authors: David T
authors: DT
authors: Rispler
authors: John W
authors: JW
authors: Stirton
authors: Alex K
authors: AK
authors: Gilde
authors: Kevin R
authors: KR
authors: Kane
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D009164:Mycobacterium Infections / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000628:therapy; D012293:Rifampin / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D000995:Antitubercular Agents; D001500:BCG Vaccine; D019496:Cancer Vaccines; D007538:Isoniazid; D012293:Rifampin