title: Radiation dosimetry estimation of N-(2-[(18)F]fluoropropionyl)- L-glutamate based on the mice distribution data.
abstract: N-(2-[(18)F]fluoropropionyl)-l-glutamate([(18)F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography-computer tomography (PET-CT). The absorbed and effective radiation doses resulting from the intravenous administration of [(18)F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [(18)F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4μGy/MBq, the brain received the lowest dose, 5.5μGy/MBq, and other organs received doses in the range of 8.3-11.9μGy/MBq. The effective dose was 17.0μSv/MBq. The data show that a 370MBq (10mCi) injection of [(18)F]FPGLU would lead to an estimated effective dose of 6.3mSv, which is within the accepted range of routine nuclear medicine investigations.
authors: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.
authors: Caihua
authors: C
authors: Tang
authors: Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.
authors: Zeqing
authors: Z
authors: Xu
authors: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors: Kongzhen
authors: K
authors: Hu
authors: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors: Baoguo
authors: B
authors: Yao
authors: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: gtang0224@126.com.
authors: Ganghua
authors: G
authors: Tang
authors: PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors: Dahong
authors: D
authors: Nie
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes; D005971:Glutamates / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D023421:Models, Animal; D049268:Positron-Emission Tomography / Q000379:methods; D011874:Radiometry / Q000379:methods; D019275:Radiopharmaceuticals; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D005971:Glutamates; C000603314:N-(2-fluoropropionyl)glutamic acid; D019275:Radiopharmaceuticals
keywords: Biodistribution; Dosimetry; N-(2-[(18)F]fluoropropionyl)-l-glutamate