title: Proton therapy in the management of non-Hodgkin lymphoma.
abstract: Proton therapy (PT) is a highly conformal type of radiation therapy that can target the tumor while sparing dose to surrounding normal tissues. This study reviews a single institution's experience managing patients with non-Hodgkin lymphoma (NHL) treated with PT. Eleven patients with NHL were treated with PT from January 2008 to January 2014 on an institutional review board-approved outcomes tracking protocol, and included patients with indolent orbital lymphoma (n = 4), primary mediastinal B-cell lymphoma (n = 3), plasmablastic lymphoma (n = 2) and natural killer (NK) T-cell lymphoma (n = 2). The median follow-up was 38 months. The 2-year rate of local control was 91%, with one patient with NK T-cell lymphoma having recurrence in-field. Toxicities were limited to grade 2 at highest, during follow-up. PT is a feasible and effective treatment for NHL. Early outcomes are favorable. Longer follow-up and more patients are needed to confirm our findings.
authors: a University of Florida Proton Therapy Institute , Jacksonville , FL , USA.
authors: Suzanne
authors: S
authors: Sachsman
authors: a University of Florida Proton Therapy Institute , Jacksonville , FL , USA.
authors: Stella
authors: S
authors: Flampouri
authors: a University of Florida Proton Therapy Institute , Jacksonville , FL , USA.
authors: Zuofeng
authors: Z
authors: Li
authors: b Department of Hematology and Oncology , University of Florida, College of Medicine , Gainesville , FL , USA.
authors: James
authors: J
authors: Lynch
authors: a University of Florida Proton Therapy Institute , Jacksonville , FL , USA.
authors: Nancy P
authors: NP
authors: Mendenhall
authors: a University of Florida Proton Therapy Institute , Jacksonville , FL , USA.
authors: Bradford S
authors: BS
authors: Hoppe
mesh_terms: D000328:Adult; D000368:Aged; D002386:Cataract / Q000209:etiology; D002675:Child, Preschool; D003872:Dermatitis / Q000209:etiology; D005221:Fatigue / Q000209:etiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D008875:Middle Aged; D061766:Proton Therapy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Lymphoma and Hodgkin disease; outcomes; proton beam therapy; radiation