title: Stereoselective Radical C-H Alkylation with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis.
abstract: Co(II)-based metalloradical catalysis has been, for the first time, successfully applied for asymmetric intramolecular C-H alkylation of acceptor/acceptor-substituted diazo reagents. Through the design and synthesis of a newD2-symmetric chiral amidoporphyrin as the supporting ligand, the Co(II)-based metalloradical system, which operates at room temperature, is capable of 1,5-C-H alkylation of α-methoxycarbonyl-α-diazosulfones with a broad range of electronic properties, providing the 5-membered sulfolane derivatives in high yields with excellent diastereoselectivity and enantioselectivity. In addition to complete chemoselectivity toward allylic and allenic C-H bonds, the Co(II)-based metalloradical catalysis for asymmetric C-H alkylation features a remarkable degree of functional group tolerance.
authors: Department of Chemistry, University of South Florida Tampa, FL 33620-5250 (USA)., ;
authors: Xin
authors: X
authors: Cui
authors: Department of Chemistry, University of South Florida Tampa, FL 33620-5250 (USA)., ;
authors: Xue
authors: X
authors: Xu
authors: Department of Chemistry, University of South Florida Tampa, FL 33620-5250 (USA)., ;
authors: Li-Mei
authors: LM
authors: Jin
authors: Department of Chemistry, University of South Florida Tampa, FL 33620-5250 (USA)., ;
authors: Lukasz
authors: L
authors: Wojtas
authors: Department of Chemistry, University of South Florida Tampa, FL 33620-5250 (USA)., ;
authors: X Peter
authors: XP
authors: Zhang