title: Analysis of Driven Nanorod Transport Through a Biopolymer Matrix.
abstract: Applying magnetic fields to guide and retain drug-loaded magnetic particlesin vivohas been proposed as a way of treating illnesses. Largely, these efforts have been targeted at tumors. One significant barrier to long range transport within tumors is the extracellular matrix (ECM). We perform single particle measurements of 18 nm diameter nanorods undergoing magnetophoresis through ECM, and analyze the motion of these nanorods in two dimensions. We observe intra-particle magnetophoresis in this viscoelastic environment and measure the fraction of time these nanorods spend effectively hindered, versus effectively translating.
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Lamar O
authors: LO
authors: Mair
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Irving N
authors: IN
authors: Weinberg
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Alek
authors: A
authors: Nacev
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Mario G
authors: MG
authors: Urdaneta
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Pavel
authors: P
authors: Stepanov
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Ryan
authors: R
authors: Hilaman
authors: Weinberg Medical Physics LLC, Bethesda, MD 20817 USA.
authors: Stephanie
authors: S
authors: Himelfarb
authors: Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599 USA.
authors: Richard
authors: R
authors: Superfine
keywords: extracellular matrix; magnetic nanorods; magnetophoresis; particle tracking