title: Manipulation of ionic liquid anion-solute-antisolvent interactions for the purification of acetaminophen.
abstract: Hydrogen bond donating cosolvents have been shown to significantly reduce the solubility of acetaminophen (AAP) in ionic liquids containing the acetate anion. Reduced solubility arises from competition for solvation by the acetate anion and can be used for the design of advanced separation techniques, illustrated by the crystallization of AAP.
authors: Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. myerson@mit.edu.
authors: C C
authors: CC
authors: Weber
authors: A J
authors: AJ
authors: Kunov-Kruse
authors: R D
authors: RD
authors: Rogers
authors: A S
authors: AS
authors: Myerson
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000627:Aminophenols / Q000737:chemistry; D003460:Crystallization; D006860:Hydrogen Bonding; D052578:Ionic Liquids / Q000737:chemistry*; D012995:Solubility
chemical_list: D000627:Aminophenols; D052578:Ionic Liquids; D000082:Acetaminophen; C026729:4-aminophenol