title: Opuntia ficus indica peel derived pectin mediated hydroxyapatite nanoparticles: synthesis, spectral characterization, biological and antimicrobial activities.
abstract: In the present study, we have adapted a facile and efficient green route for the synthesis of HAP nanoparticles using pectin as a template which was extracted from the peel of prickly pear (Opuntia ficus indica) fruits. The concentration of pectin plays a major role in the behavior of crystallinity, purity, morphology as well as biological property of the as-synthesized HAP nanoparticles. The extracted pectin and the as-synthesized nanoparticles were characterized by various analytical techniques. The in vitro apatite formation on the surface of the as-synthesized nanoparticles in simulated body fluid (SBF) for various days showed an enhanced bioactivity. Also, the antimicrobial activity was investigated using various microorganisms. All the results revealed the formation of pure, low crystalline and discrete granular like HAP nanoparticles of size around 25 nm with enhanced biological and antimicrobial activities. Hence the as-synthesized nanoparticles can act as a better bone regenerating material in the field of biomedicine.
authors: Department of Chemistry, Periyar University, Salem 636 011, Tamil Nadu, India; Centre for Nanoscience and Nanotechnology, Periyar University, Salem 636 011, Tamil Nadu, India. Electronic address: dhanaraj_gopi@yahoo.com.
authors: D
authors: D
authors: Gopi
authors: Department of Chemistry, Periyar University, Salem 636 011, Tamil Nadu, India.
authors: K
authors: K
authors: Kanimozhi
authors: Department of Physics, School of Basic and Applied Sciences, Central University of Tamil Nadu, Thiruvarur 610 101, Tamil Nadu, India.
authors: L
authors: L
authors: Kavitha
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D003460:Crystallization; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D029747:Opuntia / Q000737:chemistry*; D010316:Particle Size; D010368:Pectins / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013054:Spectrophotometry, Atomic; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D010368:Pectins; D017886:Durapatite
keywords: Bioactivity; Green route; Hydroxyapatite; Nanoparticles; Opuntia ficus indica; Simulated body fluid