title: Two protocols to treat thin endometrium with granulocyte colony-stimulating factor during frozen embryo transfer cycles.
abstract: The efficacy of two granulocyte colony-stimulating factor (G-CSF) protocols for thin endometrium were investigated. Eighty-two patients were diagnosed with thin endometrium (<7 mm). Thirty patients with previously cancelled embryo transfers received intrauterine G-CSF in subsequent frozen embryo transfer (FET) cycles. Patients were divided into the G-CSF only and G-CSF with endometrial scratch subgroups. Compared with previous cycles, endometrial thickness increased from 5.7 ± 0.7 mm to 8.1 ± 2.1 mm after G-CSF treatment (P < 0.001). Endometrial thickness increases were not significantly different between the two subgroups. The G-CSF with endometrial scratch subgroup established nominally higher though non-significant clinical pregnancy and live birth rates than the G-CSF only subgroup (53.8 % versus 42.9% and 38.5% versus 28.6%, respectively). Fifty-two patients underwent FET despite edometrial thickness less than 7 mm, and were included as controls. Significantly higher embryo implantation and clinical pregnancy rates were observed in the G-CSF group compared with the control group (31.5% versus 13.9%; P < 0.01; 48.1% versus 25.0%; P = 0.038, respectively). Endometrial scracth did not impair G-CSF treatment for thin endometrium and favoured pregnancy and live birth rates. For patients with thin endometrium, embryo transfer cancellation and G-CSF treatment in subsequent FET cycles is beneficial.
authors: Reproductive Medicine Center, Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, 87 Xiangya Rd., Changsha City, Hunan Province 410008, China.
authors: Bin
authors: B
authors: Xu
authors: Reproductive Medicine Center, Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, 87 Xiangya Rd., Changsha City, Hunan Province 410008, China.
authors: Qiong
authors: Q
authors: Zhang
authors: Reproductive Medicine Center, Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, 87 Xiangya Rd., Changsha City, Hunan Province 410008, China.
authors: Jie
authors: J
authors: Hao
authors: Department of Gynecology, Third Xiangya Hospital of Central South University, 138 Tongzipo Rd., Changsha City, Hunan Province 410013, China.
authors: Dabao
authors: D
authors: Xu
authors: Reproductive Medicine Center, Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, 87 Xiangya Rd., Changsha City, Hunan Province 410008, China. Electronic address: lisayanping@sina.com.
authors: Yanping
authors: Y
authors: Li
mesh_terms: D000328:Adult; D010064:Embryo Implantation / Q000187:drug effects*; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: endometrial scratch; frozen embryo transfer; granulocyte colony-stimulating factor; pregnancy rate; thin endometrium