title: Cytoreductive surgery and hyperthermic intrapleural chemotherapy for malignant pleural diseases: preliminary experience.
abstract: Cytoreductive surgery and hyperthermic-intraoperative-intrapleural-chemotherapy (HITHOC) is a known approach for malignant pleural diseases (MPD). This study was started to clarify the role of cytoreductive surgery and HITHOC in MPD. Criteria of inclusion were early-stage disease in malignant pleural mesothelioma (MPM), young age, good condition and selected stage-M1a lung cancer. Six patients with MPM and two patients with lung cancer were enrolled. After surgical debulking, intrapleural cisplatin was administered for 60 min at 42.5°C. Wedge, rib resection and repaired diaphragm were added in three, one and one patient, respectively. Morbidity, toxicity and mortality was nil. Hospital stay was 8 days. Mean survival is 13.6 months. This experience confirms that cytoreductive surgery and HITHOC is a good option in the treatment of MPD. A randomized controlled trial is necessary.
authors: Academic Thoracic Surgery Unit, A.O.U. Policlinico-Vittorio Emanuele, Department of Surgery, University of Catania, Catania, Italy.
authors: Marcello
authors: M
authors: Migliore
authors: Damiano
authors: D
authors: Calvo
authors: Alessandra
authors: A
authors: Criscione
authors: Cristina
authors: C
authors: Viola
authors: Giuseppe
authors: G
authors: Privitera
authors: Corrado
authors: C
authors: Spatola
authors: Hector Soto
authors: HS
authors: Parra
authors: Stefano
authors: S
authors: Palmucci
authors: Nicola
authors: N
authors: Ciancio
authors: Rosario
authors: R
authors: Caltabiano
authors: Giuseppe
authors: G
authors: Di Maria
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D065426:Cytoreduction Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D019616:Thoracic Surgical Procedures / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: HITHOC; advanced lung cancer; chemotherapy; cytoreductive surgery; hyperthermic perfusion; lung cancer; mesothelioma; multimodality treatment