title: Hypoalbuminemia is a surrogate biomarker of poor prognosis in myelodysplastic syndrome even when adjusting for comorbidities.
abstract: The serum albumin (SA) level has been reported to be an independent prognostic biomarker that may serve as a surrogate representative of disease biology in patients diagnosed with myelodysplastic syndrome (MDS). However, its prognostic ability has not been tested in a model adjusting for comorbidities. We analyzed 200 patients who were diagnosed as having de novo MDS. Median overall survival (OS) of all patients was 25 months and median leukemia-free survival (LFS) was 24 months. Median OS according to the SA level groups of ≤ 3.5, 3.6-4.0 and > 4.0 mg/dL were 24, 39 and 77 months, respectively. SA level remained an independent predictor of both LFS and OS even when adjusting for the hematopoietic cell transplant comorbidity index (HCT-CI) and the International Prognostic Scoring System (IPSS) or World Health Organization classification-based Prognostic Scoring System (WPSS). Our findings indicate that SA level at the time of diagnosis is a significant and independent predictor of LFS and OS even when adjusting for commonly used prognostic systems and comorbidities.
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Omur Gokmen
authors: OG
authors: Sevindik
authors: b Department of Oncology , Dokuz Eylul University , Izmir , Turkey.
authors: Zeynep
authors: Z
authors: Guc
authors: c Department of Hematology , Medical Park Hospital , Izmir , Turkey.
authors: Selda
authors: S
authors: Kahraman
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Serife
authors: S
authors: Medeni Solmaz
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Abdullah
authors: A
authors: Katgi
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Celal
authors: C
authors: Acar
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Inci
authors: I
authors: Alacacioglu
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Ozden
authors: O
authors: Piskin
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Guner Hayri
authors: GH
authors: Ozsan
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Fatih
authors: F
authors: Demirkan
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Bulent
authors: B
authors: Undar
authors: a Department of Hematology , Dokuz Eylul University , Izmir , Turkey.
authors: Mehmet Ali
authors: MA
authors: Ozcan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015897:Comorbidity; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood* / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin
keywords: HCT-CI; Myelodysplastic syndrome; albumin; leukemia-free survival; overall survival