title: Incidence and profile of C3 Glomerulopathy: A single center study.
abstract: C3 glomerulopathy has recently been described as a distinct entity. The underlying mechanism is unregulated activation of the alternate pathway of the complement system. The most common presentation is with an acute nephritic syndrome. The diagnosis is made on immunofluoroscence by the presence of isolated or dominant C3 staining. In this retrospective study, renal biopsy data were collected from 2010 to 2013 patients with C3 glomerulopathy identified and their clinical and biochemical parameters analyzed. Out of 514 biopsies available for analysis, the incidence of C3 glomerulopathy was 1.16% (n = 6). The mean age of the presentation was 26 years and the average estimated glomerular filtration rate was 30.65 ml/min/1.73 m(2). The most common histopathological pattern was membranoproliferative glomerulonephritis (n = 4).
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: M
authors: M
authors: Mathur
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: S
authors: S
authors: Sharma
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: D
authors: D
authors: Prasad
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: R
authors: R
authors: Garsa
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: A P
authors: AP
authors: Singh
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: R
authors: R
authors: Kumar
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: P
authors: P
authors: Beniwal
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: D
authors: D
authors: Agarwal
authors: Department of Nephrology, SMS Medical College, Jaipur, Rajasthan, India.
authors: V
authors: V
authors: Malhotra
keywords: Alternate pathway; C3 glomerulopathy; membranoproliferative glomerulonephritis; plasma therapy