title: Plasma fatty acid profile in multiple myeloma patients.
abstract: New membrane formation in the proliferating tumor cells consequently results in hypermetabolism of fatty acids (FA), as seen in many cancer patients, including multiple myeloma (MM). The FA composition of plasma reflects both endogenous synthesis as well as the dietary supply of these compounds. Additionally, obesity is a risk factor for the development of MM. The aim of this study was to compare the FA composition of plasma in 60 MM patients and 60 healthy controls. We noted significant differences in the FA profile of plasma from patients with MM when compared to the control group. Increased levels of saturated and n-6 polyunsaturated fatty acids in MM patients suggest that there may be increased endogenous synthesis of these fatty acids, likely due to increased expression of desaturase and elongase. Furthermore, cluster analysis showed differences in the distribution of FA in plasma from MM patients compared to controls. Dietary fat and a deranged endogenous FA metabolism may contribute to cancer-associated inflammation through an abnormal arachidonic acid metabolism, caused by pro-inflammatory derivatives. Our study supports further research on the biochemistry of lipids in patients with MM.
authors: Department of Hematology, University Hospital, Krakow, Poland. Electronic address: mmjurczy@cyf-kr.edu.pl.
authors: Artur
authors: A
authors: Jurczyszyn
authors: Department of Infectious Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors: Jacek
authors: J
authors: Czepiel
authors: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
authors: Joanna
authors: J
authors: Gdula-Argasińska
authors: Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
authors: Paweł
authors: P
authors: Paśko
authors: Faculty of Management, AGH University of Science and Technology, Krakow, Poland.
authors: Anna
authors: A
authors: Czapkiewicz
authors: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
authors: Tadeusz
authors: T
authors: Librowski
authors: Department of Medicine, John Dempsey Hospital, University of Connecticut, Farmington, CT, USA.
authors: William
authors: W
authors: Perucki
authors: Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University, Wroclaw, Poland; Department of Physiology, Medical University, Wroclaw, Poland.
authors: Aleksandra
authors: A
authors: Butrym
authors: Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, USA.
authors: Jorge J
authors: JJ
authors: Castillo
authors: Department of Hematology, University Hospital, Krakow, Poland.
authors: Aleksander B
authors: AB
authors: Skotnicki
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis*; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D005227:Fatty Acids
keywords: Desaturase activity; Fatty acids; Gas chromatography; Multiple myeloma; Plasma