title: Cortical Bone Mineralization in the Human Femoral Neck in Cases and Controls from Synchrotron Radiation Study.
abstract: To compare the degree and distribution of mineralization in femoral neck cortex from 23 women with hip fractures (age 65-96 years) and 17 female controls (age 72-103 years), we obtained 3D data by synchrotron radiation microtomography (SRμCT). Variables were degree of mineralization of bone (DMB) in total cortex (cDMBSRMEAN), osteons (oDMBSRMEAN), and pure interstitial tissue (intDMBSRMEAN). The cortex on SRμCT images was divided into nine to twelve 50-μm zones from the periosteum to the endosteum; cDMBSRMEAN, oDMBSRMEAN, and intDMBSRMEAN were measured in each zone. We used descriptive statistics and t tests, general linear model analyses to compare DMBSR values across zones and individuals, one-way analysis of variance for within-group comparisons of zones. In patients, the variance of mineral content value was not different than in controls, but mean values of degree of mineralization varied across zones. These cross-sectional data suggest that bone fragility may be related to a greater heterogeneity of the distribution of mineralization in femoral neck cortex.
authors: Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jian She Road, Zhengzhou, 450052, Henan, China. yanzi155@hotmail.com.|Laboratoire de Radiologie Expérimentale, Faculté de Médecine Lariboisière-Saint Louis, Université Paris VII, CNRS UMR 7052, 10 avenue de Verdun, 75010, Paris, France. yanzi155@hotmail.com.
authors: Yan
authors: Y
authors: Wu
authors: Laboratoire de Radiologie Expérimentale, Faculté de Médecine Lariboisière-Saint Louis, Université Paris VII, CNRS UMR 7052, 10 avenue de Verdun, 75010, Paris, France.|Department of Medical Engineering, Inner Mongolia People's Hospital, Hohhot, 010017, China.
authors: Liangqiang
authors: L
authors: Zhou
authors: Laboratoire de Radiologie Expérimentale, Faculté de Médecine Lariboisière-Saint Louis, Université Paris VII, CNRS UMR 7052, 10 avenue de Verdun, 75010, Paris, France.
authors: Catherine
authors: C
authors: Bergot
authors: CREATIS, ESRF, BP 220, 38043, Grenoble Cedex, France.
authors: Françoise
authors: F
authors: Peyrin
authors: Laboratoire de Radiologie Expérimentale, Faculté de Médecine Lariboisière-Saint Louis, Université Paris VII, CNRS UMR 7052, 10 avenue de Verdun, 75010, Paris, France.
authors: Valérie
authors: V
authors: Bousson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002113:Calcification, Physiologic; D016022:Case-Control Studies; D000071538:Cortical Bone / Q000000981:diagnostic imaging* / Q000293:injuries; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging* / Q000293:injuries; D006620:Hip Fractures / Q000000981:diagnostic imaging*; D006801:Humans; D055114:X-Ray Microtomography
keywords: Femoral neck cortex; Mineralization; Synchrotron radiation microtomography