title: Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
abstract: This study was designed to investigate whether phlorofucofuroeckol A inhibited α-glucosidase and α-amylase activities and alleviated postprandial hyperglycemia in diabetic mice. Phlorofucofuroeckol A that was isolated from Ecklonia cava (brown algae) demonstrated prominent inhibitory effects against α-glucosidase and α-amylase activities. The IC50 values of phlorofucofuroeckol A against α-glucosidase and α-amylase were 19.52 and 6.34μM, respectively. These inhibitory activities of phlorofucofuroeckol A were higher than those of acarbose, which was used as a positive control. Increases in postprandial blood glucose levels were significantly more suppressed in the group administered phlorofucofuroeckol A compared to the control group in both diabetic and normal mice. Moreover, the area under the curve was significantly lower after phlorofucofuroeckol A administration (2296 versus 2690mmolmin/l) in the diabetic mice. These results suggested that phlorofucofuroeckol A is a potent α-glucosidase inhibitor and can alleviate the postprandial hyperglycemia that is caused by starch.
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: yuhn1031@gmail.com.
authors: Han-Nui
authors: HN
authors: You
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: dublin79@naver.com.
authors: Hyun-Ah
authors: HA
authors: Lee
authors: Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Republic of Korea.
authors: Mi-Hwa
authors: MH
authors: Park
authors: Department of Marine Life Science, Jeju National University, Jeju 690-756, Republic of Korea.
authors: Ji-Hyeok
authors: JH
authors: Lee
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: hanjs@pusan.ac.kr.
authors: Ji-Sook
authors: JS
authors: Han
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004147:Dioxins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000459:Phaeophyceae / Q000737:chemistry*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001572:Benzofurans; D001786:Blood Glucose; D004147:Dioxins; D065089:Glycoside Hydrolase Inhibitors; C064093:phlorofucofuroeckol A; D000516:alpha-Amylases; D000520:alpha-Glucosidases
keywords: Diabetic mice; Phlorofucofuroeckol A; Postprandial hyperglycemia; α-glucosidase