title: Diversity-oriented approach for chemical biology.
abstract: Synthetic molecules that modulate and probe biological events are critical tools in chemical biology. Utilizing combinatorial and diversity-oriented synthetic strategies, access to large numbers of small molecules is becoming more and more feasible, and research groups in this field can take advantage of the power of chemical diversity. Since the majority of early studies were focused on the discovery of compounds that perturb protein functions, diversity-based approaches are often considered as therapeutic lead discovery tactics. However, the diversity-oriented approach can also be applied to advance distinct aims, such as target protein identification, or the development of imaging probes and sensors. This review provides a personal perspective of the chemical-diversity-based approach and how this principle can be adapted to various chemical biology studies.
authors: Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seoul, 136-791, Republic of Korea; Department of Biological Chemistry, University of Science and Technology (UST), 113 Gwahank-ro, Yuseong-gu, Daejeon, 305-333, Republic of Korea.
authors: Jun-Seok
authors: JS
authors: Lee
authors: Jae Wook
authors: JW
authors: Lee
authors: Namyoung
authors: N
authors: Kang
authors: Hyung-Ho
authors: HH
authors: Ha
authors: Young-Tae
authors: YT
authors: Chang
mesh_terms: D000818:Animals; D001692:Biological Transport; D015374:Biosensing Techniques / Q000379:methods*; D017173:Caenorhabditis elegans / Q000254:growth & development / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000032:analysis / Q000378:metabolism; D015195:Drug Design; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006493:Heparin / Q000032:analysis / Q000378:metabolism; D057166:High-Throughput Screening Assays; D009024:Morphogenesis / Q000235:genetics; D012313:RNA / Q000032:analysis / Q000378:metabolism; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry*; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D054852:Small Molecule Libraries; D014227:Triazines; D012313:RNA; D006493:Heparin; D004247:DNA
keywords: fluorescent probes; high-throughput screening; molecular diversity; sensors; target identification