title: Serum/plasma microRNAs as biomarkers for HBV-related hepatocellular carcinoma in China.
abstract: MicroRNAs (miRNAs) are a group of small RNAs with a fundamental role in the regulation of gene expression. These RNAs have been shown to participate in various cellular and physiological processes, including cellular development, apoptosis, proliferation, and differentiation. Aberrant expression of several miRNAs was found to be involved in a large variety of neoplasms, including hepatocellular carcinoma (HCC). Previous studies have shown the existence of a large amount of stable miRNAs in human serum/plasma, which laid the foundation for studying the role of serum/plasma miRNAs in the diagnosis and prognosis of HCC. Here, we review the recent progress in research on serum miRNAs as biomarkers for HCC in Chinese patients.
authors: Department of Microbiology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors: Wen
authors: W
authors: Yin
authors: Department of Gastroenterology, First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
authors: Yan
authors: Y
authors: Zhao
authors: Department of Medicine, Jinan 2nd People's Hospital, Jinan, Shandong 250001, China.
authors: Yong-Jing
authors: YJ
authors: Ji
authors: Department of Out-Patient, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors: Li-Ping
authors: LP
authors: Tong
authors: Department of Out-Patient, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors: Ya
authors: Y
authors: Liu
authors: Department of Gastroenterology, First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
authors: Shui-Xiang
authors: SX
authors: He
authors: Department of Microbiology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors: Ai-Qin
authors: AQ
authors: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000821:virology*; D002681:China; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000821:virology*; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs