title: [Diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in fever of unknown origin].
abstract: OBJECTIVE
  To evaluate the diagnostic value of fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) in fever of unknown origin (FUO) in a Chinese hospital.
  
  
  METHODS
  The records of 51 patients with FUO (32 men and 19 women; mean age 54 years with a range between 3 and 81 years) were analyzed retrospectively. All the patients were examined by ¹⁸F-FDG PET/CT scan and the results were compared with the final diagnosis which was established by additional procedures including pathology, laboratory examination, and clinical follow-up for more than 3 months. The t test was used for statistical analysis.
  
  
  RESULTS
  A final diagnosis was established for 48 patients, including 32 patients with infectious diseases, 9 with malignancies, and 7 with non-infectious inflammatory diseases. By FDG PET scan alone, the rates of true positive, false positive, false negative, and true negative were 52.9%, 27.5%, 17.6%, and 2.0%, respectively. By FDG PET/CT scan, the rates of true positive, false positive, false negative, and true negative were 70.6%, 27.5%, 2.0%, and 0, respectively. ¹⁸F-PET/CT had a sensitivity of 97.3% (36/37), specificity of 0 (0/14), and accuracy of 70.6% (36/51) in FUO, especially a high sensitivity and accuracy of 100% (9/9) in the diagnosis of malignant tumor. Moreover, the maximum standardized uptake value (SUVmax) in tumor was significant higher than that in infection (3.7 ± 2.7 vs. 7.7 ± 3.5, P=0.001, t=3.6), which implied that SUVmax might be useful in differential diagnosis in FUO.
  
  
  CONCLUSIONS
  FDG PET/CT is a valuable imaging tool for the identification and location of the potential lesion in FUO and is helpful for the etiological diagnosis, especially in the diagnosis of malignant lesions.
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Lei
authors: L
authors: Kang
authors: Department of Medical Molecular Biology, Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100850, China.
authors: Xiao-jie
authors: XJ
authors: Xu
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Yan
authors: Y
authors: Fan
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Rong-fu
authors: RF
authors: Wang
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Chao
authors: C
authors: Ma
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Zhan-li
authors: ZL
authors: Fu
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Jian-hua
authors: JH
authors: Zhang
authors: Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.
authors: Xu-chu
authors: XC
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18