title: Alteration of WWOX in human cancer: a clinical view.
abstract: WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.
authors: Department of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, Poland.
authors: Izabela
authors: I
authors: Baryła
authors: Department of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, Poland.
authors: Ewa
authors: E
authors: Styczeń-Binkowska
authors: Department of Molecular Carcinogenesis, Medical University of Lodz, 90-752 Lodz, Poland andrzej.bednarek@umed.lodz.pl.
authors: Andrzej K
authors: AK
authors: Bednarek
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000503:physiopathology; D019656:Loss of Heterozygosity / Q000235:genetics / Q000502:physiology; D008297:Male; D009154:Mutation / Q000235:genetics / Q000502:physiology; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D010088:Oxidoreductases / Q000235:genetics* / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000503:physiopathology; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000502:physiology*; D000074584:WW Domain-Containing Oxidoreductase
chemical_list: D025521:Tumor Suppressor Proteins; D010088:Oxidoreductases; D000074584:WW Domain-Containing Oxidoreductase; C486071:WWOX protein, human
keywords: WWOX; cancer; tumor suppressor gene