title: Autoantibodies 2015: From diagnostic biomarkers toward prediction, prognosis and prevention.
abstract: At the 12th International Workshop on Autoantibodies and Autoimmunity (IWAA), organized in August 2014 in Sao Paulo, Brazil, more than 300 autoimmunologists gathered to discuss the status of many novel autoantibodies in clinical practice, and to envisage additional value of autoantibodies in terms of prediction, prognosis and prevention of autoimmune diseases. Two separate workshops were dedicated to standardization and harmonization of autoantibody testing and nomenclature: International Autoantibody Standardization (IAS) and International Consensus on ANA Patterns (ICAP). It was apparent to all in attendance that the discovery and elucidation of novel autoantibodies did not slow down, but that multiple challenges lay ahead of us in order to apply these discoveries to effective and efficient clinical practice. Importantly, this requires optimal bidirectional communication between clinicians and laboratory specialists, as well as close collaboration with the diagnostic industry. This paper is a report on the 12th IWAA in combination with a review of the recent developments in the field of autoantibodies.
authors: Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: jan.damoiseaux@mumc.nl.
authors: Jan
authors: J
authors: Damoiseaux
authors: Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Immunology Division, Fleury Medicine and Health Laboratories, Sao Paulo, Brazil.
authors: Luis E
authors: LE
authors: Andrade
authors: Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors: Marvin J
authors: MJ
authors: Fritzler
authors: The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
authors: Yehuda
authors: Y
authors: Shoenfeld
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control; D015415:Biomarkers / Q000032:analysis; D001938:Brazil; D003226:Congresses as Topic; D006801:Humans; D007249:Inflammation / Q000276:immunology; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D015415:Biomarkers
keywords: Autoantibodies; Diagnosis; Harmonization; Standardization