title: Creatine phosphokinase elevation exacerbated by levetiracetam therapy.
abstract: A 19-year-old muscular male with a history of epilepsy presented following two convulsive events. Levetiracetam (LEV) was given as an additional therapy, resulting in a marked boost in creatine phosphokinase (CPK) that could not easily be explained by renal dysfunction or rhabdomyolysis alone. Levetiracetam discontinuation caused CPK levels to quickly normalize and should be considered in patients with persisting CPK elevations postconvulsive seizure.
authors: Dartmouth College, Department of Psychological & Brain Sciences, Maynard Street, Hanover, NH 03755, USA.
authors: Julia E
authors: JE
authors: Isaacson
authors: University of Washington, School of Public Health, 1959 NE Pacific Street, Seattle, WA 98195, USA.
authors: Dongwhoon J
authors: DJ
authors: Choe
authors: Swedish Epilepsy Center, 550 17th Avenue, Seattle, WA 98122, USA.
authors: Michael J
authors: MJ
authors: Doherty
keywords: Epilepsy; Muscle; Renal; Rhabdomyolysis; Sarcolemma; Toxicity