title: Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients.
abstract: The purpose of this study was to evaluate the diagnostic value of circulating miR-765 and miR-149 as noninvasive early biomarkers for geriatric coronary artery disease (CAD) patients. A total of 69 angiographically documented CAD patients including 37 stable CAD (72.9 ± 4.2 years) and 32 unstable CAD (72.03 ± 4.3 years) and 20 healthy subjects (71.7 ± 5.2 years), matched for age, sex, smoking habit, hypertension, and diabetes, were enrolled in this study. Compared with healthy subjects, circulating miR-765 levels were increased by 2.9-fold in stable CAD and 5.8-fold in unstable CAD patients, respectively, while circulating miR-149 levels were downregulated by 3.5-fold in stable CAD and 4.2-fold in unstable CAD patients, respectively. Furthermore, plasma levels of miR-765 were found to be positively correlated with ages within control, stable, and unstable groups. The ROC curves of miR-765 and miR-149 represented significant diagnostic values with an area under curve (AUC) of 0.959, 0.972 and 0.938, 0.977 in stable CAD patients and unstable CAD patients as compared with healthy subjects, respectively. Plasma levels of miR-765 and miR-149 might be used as noninvasive biomarkers for the diagnosis of CAD in geriatric people.
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Md Sayed
authors: MS
authors: Ali Sheikh
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China ; Center for Vascular Biology and Inflammation, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
authors: Ke
authors: K
authors: Xia
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Fei
authors: F
authors: Li
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Xu
authors: X
authors: Deng
authors: Department of Gynecology and Obstetrics, Xiangya 3rd Hospital, Central South University, Changsha, China.
authors: Umme
authors: U
authors: Salma
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Hai
authors: H
authors: Deng
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Liu
authors: L
authors: Wei Wei
authors: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan 410078, China.
authors: Tian-Lun
authors: TL
authors: Yang
authors: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
authors: Jun
authors: J
authors: Peng
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D012372:ROC Curve
chemical_list: D015415:Biomarkers; C551557:MIRN149 microRNA, human; C000600151:MIRN765 microRNA, human; D035683:MicroRNAs