title: Successful treatment of generalized granuloma annulare with adalimumab.
abstract: We report the case of a 64 year-old woman who demonstrated resolution of recalcitrant, generalized granuloma annulare (GA) following treatment with adalimumab. After showing little response to other treatment techniques, such as steroids and a triple antibiotic regimen, the patient was started on adalimumab. Within 3 months, she showed almost complete resolution of lesions. Within 6 months, she was completely lesion-free, and remained clear following 12 months of adalimumab therapy. This case provides further evidence that tumour necrosis factor-α inhibitors may be a treatment option for patients with recalcitrant, generalized GA.
authors: Texas A&M Health Sciences Center College of Medicine, Bryan, TX, USA.
authors: T
authors: T
authors: Mahmood
authors: Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA.
authors: B
authors: B
authors: Mansouri
authors: Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA.
authors: A
authors: A
authors: Menter
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D005260:Female; D016460:Granuloma Annulare / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab