title: Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation.
abstract: We report the successful use of RADPLAT to treat a patient with an unresectable T4N0 sinonasal undifferentiated carcinoma. This patient received 4 cycles of weekly intra-arterial cisplatin together with thiosulfate infusion with concurrent radiation therapy. Radiation therapy was given in 28 daily fractions to 54 Gy using intensity-modulated radiation therapy followed by a hypofractionated stereotactic boost of 3 fractions to 13 Gy to a total dose of 67 Gy in 31 fractions to the nasal sinus and bilateral neck. Intra-arterial cisplatin was administered using a bilateral approach due to the midline site of this tumor. Within days of the first intra-arterial cisplatin, there was an obvious decrease in tumor size. She has been followed with magnetic resonance imaging and positron emission tomography, and remains disease-free 47 mo post-treatment. Centers with expertise in intra-arterial chemotherapy could consider the RADPLAT approach for patients with unresectable sinonasal undifferentiated carcinoma.
authors: Sonal S Noticewala, Loren K Mell, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, CA 92093, United States.
authors: Sonal S
authors: SS
authors: Noticewala
authors: Sonal S Noticewala, Loren K Mell, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, CA 92093, United States.
authors: Loren K
authors: LK
authors: Mell
authors: Sonal S Noticewala, Loren K Mell, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, CA 92093, United States.
authors: Scott E
authors: SE
authors: Olson
authors: Sonal S Noticewala, Loren K Mell, Department of Radiation Medicine and Applied Sciences, Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, CA 92093, United States.
authors: William
authors: W
authors: Read
keywords: Intra-arterial cisplatin; RADPLAT; Radiation; Sinonasal undifferentiated carcinoma; Survival