title: Numerical study of a cylinder model of the diffusion MRI signal for neuronal dendrite trees.
abstract: We study numerically how the neuronal dendrite tree structure can affect the diffusion magnetic resonance imaging (dMRI) signal in brain tissue. For a large set of randomly generated dendrite trees, synthetic dMRI signals are computed and fitted to a cylinder model to estimate the effective longitudinal diffusivity D(L) in the direction of neurites. When the dendrite branches are short compared to the diffusion length, D(L) depends significantly on the ratio between the average branch length and the diffusion length. In turn, D(L) has very weak dependence on the distribution of branch lengths and orientations of a dendrite tree, and the number of branches per node. We conclude that the cylinder model which ignores the connectivity of the dendrite tree, can still be adapted to describe the apparent diffusion coefficient in brain tissue.
authors: INRIA Saclay-Equipe DEFI, CMAP, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex, France; Neurospin, CEA Saclay, F-91191 Gif sur Yvette, France.
authors: Dang
authors: D
authors: Van Nguyen
authors: LPMC, CNRS - Ecole Polytechnique, F-91128 Palaiseau, France.
authors: Denis
authors: D
authors: Grebenkov
authors: Neurospin, CEA Saclay, F-91191 Gif sur Yvette, France.
authors: Denis
authors: D
authors: Le Bihan
authors: INRIA Saclay-Equipe DEFI, CMAP, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex, France; Neurospin, CEA Saclay, F-91191 Gif sur Yvette, France. Electronic address: jingrebecca.li@inria.fr.
authors: Jing-Rebecca
authors: JR
authors: Li
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000166:cytology*; D003198:Computer Simulation; D003712:Dendrites / Q000648:ultrastructure*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Cylinder model; Dendrite trees; Diffusion MRI; Neurites