title: Synthesis and evaluation of new 1,5-diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole derivatives as potential antidepressant agents.
abstract: In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also investigated using an activity cage apparatus. Among these derivatives, compounds 2b, 2d, 2f, 2o, and 2r decreased both horizontal and vertical activity number of the mice. On the other hand, compounds 2a, 2h, 2j, 2k, 2l, 2m, and 2n, which did not induce any significant change in the locomotor activity, significantly shortened the immobility time of mice in TST and MFST, representing the presence of the antidepressant-like effect. Additionally, the same compounds increased the swimming time of mice in MFST without any change in climbing duration, similar to the reference drug fluoxetine (10 mg/kg). In the light of previous papers examining the effects of pyrazolines on central nervous system, this study, once more, pointed out remarkable antidepressant activity potential of pyrazoline derivatives.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. ahmeto@anadolu.edu.tr.
authors: Ahmet
authors: A
authors: Özdemir
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. mdaltintop@anadolu.edu.tr.|Graduate School of Health Sciences, Anadolu University, 26470 Eskişehir, Turkey. mdaltintop@anadolu.edu.tr.
authors: Mehlika Dilek
authors: MD
authors: Altıntop
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. zakaplan@anadolu.edu.tr.
authors: Zafer Asım
authors: ZA
authors: Kaplancıklı
authors: Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
authors: Özgür Devrim
authors: ÖD
authors: Can
authors: Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. udemir@anadolu.edu.tr.
authors: Ümide
authors: Ü
authors: Demir Özkay
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. gturan@anadolu.edu.tr.
authors: Gülhan
authors: G
authors: Turan-Zitouni
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D008297:Male; D008807:Mice, Inbred BALB C; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D013315:Stress, Psychological; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D011720:Pyrazoles